[ { "uniprot_canonical_ac": "Q6WVG3-1", "uniprot_id": "KCD12_MOUSE", "mass": 35892.0, "length": 327, "protein_name": "BTB/POZ domain-containing protein KCTD12", "gene_name": "Kctd12", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein KCTD12", "refseq_ac": "NP_808383", "gene_names_uniprotkb": "Kctd12; Pfet1", "gene_names_refseq": "Kctd12; Pfet1; Pfetin", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD12; Pfetin; Predominantly fetal expressed T1 domain", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD12; potassium channel tetramerization domain containing 12; predominantly fetal expressed T1 domain", "tax_id": 10090, "disease": "", "pathway": " (mmu:239217)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "15345747;15357420;17242355;18034455;20400944;21183079;21750661;26740625;33285230;33300544;34428180;35017224;35820727", "class_list": "", "function": "Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization., [UniProtKB, UniProtKB, UniProtKB, PubMed]; KCTD8 and KCTD12 Facilitate Axonal Expression of GABAB Receptors in Habenula Cholinergic Neurons., [RefSeq, PubMed]; New gene encoding 327 amino acids in mouse contains a voltage-gated potassium (K+) channel tetramerization (T1) domain., [RefSeq, PubMed]; The effects of Kctd12, an auxiliary subunit of GABAB receptor in dentate gyrus on behavioral response to chronic social defeat stress in mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9E3", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0099579 G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential;GO:0150047 G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0043235 receptor complex;GO:0045211 postsynaptic membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0008277 regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q6WVG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VM9-1", "uniprot_id": "IPYR2_MOUSE", "mass": 38115.0, "length": 330, "protein_name": "Inorganic pyrophosphatase 2, mitochondrial", "gene_name": "Ppa2", "organism": "Mouse", "refseq_name": "inorganic pyrophosphatase 2, mitochondrial isoform 2 precursor", "refseq_ac": "NP_001280570", "gene_names_uniprotkb": "Ppa2", "gene_names_refseq": "1110013G13Rik; Ppa2; Sid6306", "protein_names_uniprotkb": "Inorganic pyrophosphatase 2, mitochondrial; 3.6.1.1; PPase 2; Pyrophosphate phospho-hydrolase 2", "protein_names_refseq": "PPase 2; inorganic pyrophosphatase 2, mitochondrial isoform 2 precursor; inorganic pyrophosphatase 2, mitochondrial; pyrophosphate phospho-hydrolase 2", "tax_id": 10090, "disease": "myocarditis (Disease Ontology:DOID:820)", "pathway": " (mmu:74776); (R-MMU-379726); (R-MMU-71737)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "21672589;21750661;23576753;23806337;24788674;28135057;28528544;34428180;37507081", "class_list": "", "function": "Downregulation of protein phosphatase 2 activity in PINK1-silenced cells promotes the protective effect of autophagy through phosphorylation of Bcl-2, [RefSeq, PubMed]; Hydrolyzes inorganic pyrophosphate. This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPK3;Q8BTG5;Q9D1E3", "ec_number_list": "3.1.3.1;3.9.1.1;3.6.1.1;3.1.3.-", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004427 inorganic diphosphate phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045202 synapse;GO:0005737 cytoplasm", "go_biological_process": "GO:0071344 diphosphate metabolic process;GO:0051881 regulation of mitochondrial membrane potential;GO:0006796 phosphate-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91VM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JM63-1", "uniprot_id": "KCJ10_MOUSE", "mass": 42432.0, "length": 379, "protein_name": "ATP-sensitive inward rectifier potassium channel 10", "gene_name": "Kcnj10", "organism": "Mouse", "refseq_name": "ATP-sensitive inward rectifier potassium channel 10", "refseq_ac": "NP_001034573", "gene_names_uniprotkb": "Kcnj10", "gene_names_refseq": "BIR10; BIRK-1; Kcnj10; Kir1.2; Kir4.1", "protein_names_uniprotkb": "ATP-sensitive inward rectifier potassium channel 10; Inward rectifier K(+) channel Kir4.1; Potassium channel, inwardly rectifying subfamily J member 10", "protein_names_refseq": "ATP-sensitive inward rectifier potassium channel 10; inward rectifier K(+) channel Kir4.1; potassium channel, inwardly rectifying subfamily J member 10", "tax_id": 10090, "disease": "EAST syndrome (Disease Ontology:DOID:0060484); autosomal recessive nonsyndromic deafness 4 (Disease Ontology:DOID:0110498); sensorineural hearing loss (Disease Ontology:DOID:10003); uveitis (Disease Ontology:DOID:13141); retinal vein occlusion (Disease Ontology:DOID:1727); transient cerebral ischemia (Disease Ontology:DOID:224); reflex epilepsy (Disease Ontology:DOID:2548); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); epilepsy with generalized tonic-clonic seizures (Disease Ontology:DOID:7725); retinal degeneration (Disease Ontology:DOID:8466); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:16513); (R-MMU-1296041); (R-MMU-1296067); (R-MMU-997272)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "11169792;19420365;25428506;30084848;33811157;9647694", "class_list": "", "function": "May be responsible for potassium buffering action of glial cells in the brain (By similarity). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0005267 potassium channel activity;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0097449 astrocyte projection;GO:0016324 apical plasma membrane;GO:0044297 cell body", "go_biological_process": "GO:0022010 central nervous system myelination;GO:0042391 regulation of membrane potential;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0007601 visual perception;GO:0007628 adult walking behavior", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JM63-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60980-1", "uniprot_id": "KLF3_MOUSE", "mass": 38561.0, "length": 344, "protein_name": "Krueppel-like factor 3", "gene_name": "Klf3", "organism": "Mouse", "refseq_name": "Krueppel-like factor 3", "refseq_ac": "NP_032479", "gene_names_uniprotkb": "Klf3; Bklf", "gene_names_refseq": "9930027G08Rik; Bklf; Klf3; Tef-2", "protein_names_uniprotkb": "Krueppel-like factor 3; Basic krueppel-like factor; CACCC-box-binding protein BKLF; TEF-2", "protein_names_refseq": "CACCC-box-binding protein BKLF; Krueppel-like factor 3; Kruppel-like factor 3 (basic); basic krueppel-like factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:16599)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12736264;15684403;21183079;21750661;32990380;34428180;34678516;36210013;36827869;36852467;40997131;8657145", "class_list": "", "function": "Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis., [UniProtKB, PubMed, PubMed]; KLF3 Transcription Activates WNT1 and Promotes the Growth and Metastasis of Gastric Cancer via Activation of the WNT/beta-Catenin Signaling Pathway., [RefSeq, PubMed]; KLF3 promotes the 8-cell-like transcriptional state in pluripotent stem cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:1990859 cellular response to endothelin;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q60980-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20444-1", "uniprot_id": "KPCA_MOUSE", "mass": 76852.0, "length": 672, "protein_name": "Protein kinase C alpha type", "gene_name": "Prkca", "organism": "Mouse", "refseq_name": "protein kinase C alpha type", "refseq_ac": "NP_035231", "gene_names_uniprotkb": "Prkca; Pkca", "gene_names_refseq": "Pkca; Prkca", "protein_names_uniprotkb": "Protein kinase C alpha type; 2.7.11.13; PKC-A; PKC-alpha", "protein_names_refseq": "PKC-A; PKC-alpha; protein kinase C alpha type; protein kinase c-alpha", "tax_id": 10090, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate carcinoma (Disease Ontology:DOID:10286); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); high grade glioma (Disease Ontology:DOID:3070); ischemia (Disease Ontology:DOID:326); chordoid glioma (Disease Ontology:DOID:3774); ovarian carcinoma (Disease Ontology:DOID:4001); large cell carcinoma (Disease Ontology:DOID:4552); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:18750); (R-MMU-111933); (R-MMU-114516); (R-MMU-1250196); (R-MMU-1433557); (R-MMU-1433559); (R-MMU-2179392); (R-MMU-3000170); (R-MMU-399997); (R-MMU-416993); (R-MMU-4419969); (R-MMU-450520); (R-MMU-5099900); (R-MMU-5218921); (R-MMU-5668599); (R-MMU-76005); (R-MMU-8853659)", "pathway_count": 17, "publication_count": 20, "publication_id_list": "10092232;12881490;18566587;19147982;20093473;20513439;23733502;2469625;25428506;2601739;30084848;30153647;31578312;33850054;34428180;35820727;39159283;7844141;8321321;9508782", "class_list": "", "function": "Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation. In cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Depending on the cell type, exhibits anti-apoptotic function and protects cells from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, or mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (By similarity). Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (PubMed:31578312). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Repeated stress to the skin amplifies neutrophil infiltration in a keratin 17- and PKCalpha-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.10.1;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;3.4.24.17;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.1.91;2.7.11.38;3.6.1.-;2.7.11.15;2.7.11.16;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;5.2.1.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005102 signaling receptor binding;GO:0005178 integrin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0001525 angiogenesis;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P20444-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZPY7-1", "uniprot_id": "KDM3B_MOUSE", "mass": 191460.0, "length": 1762, "protein_name": "Lysine-specific demethylase 3B", "gene_name": "Kdm3b", "organism": "Mouse", "refseq_name": "lysine-specific demethylase 3B", "refseq_ac": "NP_001074725", "gene_names_uniprotkb": "Kdm3b; Jhdm2b; Jmjd1b; Kiaa1082", "gene_names_refseq": "5830462I21Rik; JHDM2B; Jmjd1b; Kdm3b; mKIAA1082", "protein_names_uniprotkb": "Lysine-specific demethylase 3B; 1.14.11.65; JmjC domain-containing histone demethylation protein 2B; Jumonji domain-containing protein 1B; [histone H3]-dimethyl-L-lysine(9) demethylase 3B", "protein_names_refseq": "[histone H3]-dimethyl-L-lysine(9) demethylase 3B; jmjC domain-containing histone demethylation protein 2B; jumonji domain containing 1B; jumonji domain-containing protein 1B; lysine-specific demethylase 3B", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); lung non-small cell carcinoma (Disease Ontology:DOID:3908); colorectal cancer (Disease Ontology:DOID:9256); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:277250); (R-MMU-3214842)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21183079;21606357;21750661;22645316;25428506;34217333;34418053;36852467;39627609;40885482", "class_list": "", "function": "Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate May have tumor suppressor activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Kdm3b haploinsufficiency impairs the consolidation of cerebellum-dependent motor memory in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "B9EKS2;Q2VPQ5;Q5U5V7;Q6P9K3;Q8CCE2;Q8K2A5;Q9CU57", "ec_number_list": "1.14.11.65;1.14.11.-;1.14.99.66", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031490 chromatin DNA binding;GO:0003712 transcription coregulator activity;GO:0032454 histone H3K9 demethylase activity;GO:0140683 histone H3K9me/H3K9me2 demethylase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0070988 demethylation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q6ZPY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AUC9-1", "uniprot_id": "KLH41_MOUSE", "mass": 68190.0, "length": 606, "protein_name": "Kelch-like protein 41", "gene_name": "Klhl41", "organism": "Mouse", "refseq_name": "kelch-like protein 41", "refseq_ac": "NP_001074556", "gene_names_uniprotkb": "Klhl41; Kbtbd10", "gene_names_refseq": "Gm112; Kbtbd10; Klhl41; SARCOSIN", "protein_names_uniprotkb": "Kelch-like protein 41; Kelch repeat and BTB domain-containing protein 10", "protein_names_refseq": "kelch repeat and BTB (POZ) domain containing 10; kelch repeat and BTB domain-containing protein 10; kelch-like protein 41", "tax_id": 10090, "disease": "nemaline myopathy 9 (Disease Ontology:DOID:0110929); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); nemaline myopathy (Disease Ontology:DOID:3191)", "pathway": " (mmu:228003); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "18178185;21368295;22562206;24268659;28826497;30986853;35820727;39927985", "class_list": "", "function": "Data show that Sarcosin (Krp1) mRNA is expressed in the myotome part of the mature somites in mouse embryos from embryonic day 9.5 onwards., [RefSeq, PubMed]; Dysregulation of NRAP degradation by KLHL41 contributes to pathophysiology in nemaline myopathy., [RefSeq, PubMed]; Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells., [UniProtKB, PubMed, PubMed, PubMed]; Krp1 promotes lateral fusion of adjacent thin fibrils into mature, wide myofibrils and contribute insight into mechanisms of myofibrillogenesis and disassembly, [RefSeq, PubMed]; Loss of KLHL41 leads to nemaline myopathy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RWT7", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0035914 skeletal muscle cell differentiation;GO:2000291 regulation of myoblast proliferation;GO:0030239 myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A2AUC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E0CZ16-1", "uniprot_id": "KLHL3_MOUSE", "mass": 64922.0, "length": 587, "protein_name": "Kelch-like protein 3", "gene_name": "Klhl3", "organism": "Mouse", "refseq_name": "kelch-like protein 3 isoform 1", "refseq_ac": "NP_001349344", "gene_names_uniprotkb": "Klhl3", "gene_names_refseq": "7530408C15Rik; EG627648; Klhl3", "protein_names_uniprotkb": "Kelch-like protein 3", "protein_names_refseq": "kelch-like protein 3 isoform 1; kelch-like protein 3", "tax_id": 10090, "disease": "pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (mmu:100503085); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;22266938;22406640;24821705;25313067;25831548;28052936;30779550;35621709;36028759;37481568", "class_list": "", "function": "Generation and analysis of pseudohypoaldosteronism type II knock-in mice caused by a nonsense KLHL3 mutation in the Kelch domain., [RefSeq, PubMed]; Increased protein expression levels of WNK1 and WNK4 kinases cause PHAII by KLHL3 R528H mutation due to impaired KLHL3-Cullin3-mediated ubiquitination., [RefSeq, PubMed]; KLHL3 deficiency in mice ameliorates obesity, insulin resistance, and nonalcoholic fatty liver disease by regulating energy expenditure., [RefSeq, PubMed]; KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8, [RefSeq, PubMed]; KLHL3-dependent WNK4 degradation affected by potassium through the neddylation and autophagy pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron (PubMed:24821705, PubMed:25831548, PubMed:28052936, PubMed:35621709). The BCR(KLHL3) complex acts by mediating ubiquitination and degradation of WNK1 and WNK4, two activators of Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney, thereby regulating NaCl reabsorption (PubMed:24821705, PubMed:28052936, PubMed:35621709). The BCR(KLHL3) complex also mediates ubiquitination of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney, leading to its degradation (PubMed:25831548)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9481, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F7A5U9;I6L891", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0097602 cullin family protein binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "E0CZ16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41160-1", "uniprot_id": "LEP_MOUSE", "mass": 18709.0, "length": 167, "protein_name": "Leptin", "gene_name": "Lep", "organism": "Mouse", "refseq_name": "leptin precursor", "refseq_ac": "NP_032519", "gene_names_uniprotkb": "Lep; Ob", "gene_names_refseq": "Lep; obese; ob", "protein_names_uniprotkb": "Leptin; Obesity factor", "protein_names_refseq": "leptin precursor; obesity factor", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); obstructive sleep apnea (Disease Ontology:DOID:0050848); abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); congenital leptin deficiency (Disease Ontology:DOID:0111334); pre-eclampsia (Disease Ontology:DOID:10591); glucose intolerance (Disease Ontology:DOID:10603); short bowel syndrome (Disease Ontology:DOID:10605); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); adult respiratory distress syndrome (Disease Ontology:DOID:11394); osteoporosis (Disease Ontology:DOID:11476); familial hyperlipidemia (Disease Ontology:DOID:1168); gestational diabetes (Disease Ontology:DOID:11714); primary biliary cholangitis (Disease Ontology:DOID:12236); Huntington's disease (Disease Ontology:DOID:12858); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); breast cancer (Disease Ontology:DOID:1612); hypogonadism (Disease Ontology:DOID:1924); hyperinsulinism (Disease Ontology:DOID:2018); asthma (Disease Ontology:DOID:2841); acute pancreatitis (Disease Ontology:DOID:2913); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lipid metabolism disorder (Disease Ontology:DOID:3146); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); hepatocellular clear cell carcinoma (Disease Ontology:DOID:5016); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16846); (R-MMU-381771); (R-MMU-422085)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10660043;11373681;12594516;15122202;15899045;16825198;20620997;21750661;25060689;25232147;25383904;39695926;7984236;8589726;9732873", "class_list": "", "function": "Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (PubMed:11373681, PubMed:12594516, PubMed:15899045, PubMed:16825198, PubMed:20620997). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity) (PubMed:10660043, PubMed:12594516, PubMed:25060689, PubMed:25383904, PubMed:8589726, PubMed:9732873). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity) (PubMed:11373681, PubMed:20620997). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity) (PubMed:16825198, PubMed:20620997). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression (By similarity). Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) (PubMed:16825198). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells (Probable). Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 which promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 (PubMed:15899045). In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). Increases CD4(+)CD25(-) T cells proliferation and reduces autophagy during TCR (T cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation (PubMed:25060689)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 37, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005102 signaling receptor binding;GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding;GO:1990460 leptin receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0019953 sexual reproduction;GO:0010888 negative regulation of lipid storage;GO:2000491 positive regulation of hepatic stellate cell activation;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P41160-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02469-1", "uniprot_id": "LAMB1_MOUSE", "mass": 197090.0, "length": 1786, "protein_name": "Laminin subunit beta-1", "gene_name": "Lamb1", "organism": "Mouse", "refseq_name": "laminin subunit beta-1 precursor", "refseq_ac": "NP_032508", "gene_names_uniprotkb": "Lamb1; Lamb-1; Lamb1-1", "gene_names_refseq": "D130003D08Rik; Lamb-1; Lamb1-1; Lamb1", "protein_names_uniprotkb": "Laminin subunit beta-1; Laminin B1 chain; Laminin-1 subunit beta; Laminin-10 subunit beta; Laminin-12 subunit beta; Laminin-2 subunit beta; Laminin-6 subunit beta; Laminin-8 subunit beta", "protein_names_refseq": "laminin B1 chain; laminin B1 subunit 1; laminin subunit beta-1 precursor; laminin subunit beta-1; laminin-1 subunit beta; laminin-10 subunit beta; laminin-111; laminin-12 subunit beta; laminin-2 subunit beta; laminin-6 subunit beta; laminin-8 subunit beta", "tax_id": 10090, "disease": "leukoencephalopathy with variable cortical brain malformations and/or hydrocephalus (Disease Ontology:DOID:0112230); coloboma (Disease Ontology:DOID:12270); autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (mmu:16777)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;19349973;21183079;21750661;23472759;30899004;31219806;34427057;34428180;3493487;37507081;39927985;6209134;9219532;9454835", "class_list": "", "function": "Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of the cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 9, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 3, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "E9PXZ9", "ec_number_list": "", "go_molecular_function": "GO:0043208 glycosphingolipid binding;GO:0005178 integrin binding;GO:0019899 enzyme binding;GO:0048018 receptor ligand activity;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0031012 extracellular matrix;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0007162 negative regulation of cell adhesion;GO:0007611 learning or memory;GO:0016477 cell migration;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P02469-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJK2-1", "uniprot_id": "LANC2_MOUSE", "mass": 50777.0, "length": 450, "protein_name": "LanC-like protein 2", "gene_name": "Lancl2", "organism": "Mouse", "refseq_name": "lanC-like protein 2", "refseq_ac": "NP_598498", "gene_names_uniprotkb": "Lancl2; Tasp", "gene_names_refseq": "1700003F10Rik; Lancl2", "protein_names_uniprotkb": "LanC-like protein 2; Testis-specific adriamycin sensitivity protein", "protein_names_refseq": "lanC-like protein 2; testis-specific adriamycin sensitivity protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:71835)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;18034455;21750661;22042223;30084848;31219806;36834900", "class_list": "", "function": "Data show that LANCL2 silencing resulted in a 70% inhibition of the plasma membrane lipid peroxidation induced by abscisic acid (ABA)., [RefSeq, PubMed]; Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The ABA/LANCL1/2 Hormone/Receptor System Controls Adipocyte Browning and Energy Expenditure. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0009789 positive regulation of abscisic acid-activated signaling pathway;GO:0031179 peptide modification;GO:0009787 regulation of abscisic acid-activated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JJK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5DTI6-1", "uniprot_id": "KAL1L_MOUSE", "mass": 112525.0, "length": 991, "protein_name": "KAT8 regulatory NSL complex subunit 1-like protein", "gene_name": "Kansl1l", "organism": "Mouse", "refseq_name": "KAT8 regulatory NSL complex subunit 1-like protein isoform 1", "refseq_ac": "NP_001116210", "gene_names_uniprotkb": "Kansl1l; 1110028C15Rik; Kiaa4189", "gene_names_refseq": "1110028C15Rik; 1190030G24; C430010P07Rik; Kansl1l; mKIAA4189", "protein_names_uniprotkb": "KAT8 regulatory NSL complex subunit 1-like protein", "protein_names_refseq": "KAT8 regulatory NSL complex subunit 1-like protein isoform 1; KAT8 regulatory NSL complex subunit 1-like protein", "tax_id": 10090, "disease": "Koolen de Vries syndrome (Disease Ontology:DOID:0050880); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:68691)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;23806337;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2KGC3;E9QLD1;Q3TC00;Q8BNM1;Q8C4R5", "ec_number_list": "", "go_molecular_function": "GO:0035035 histone acetyltransferase binding", "go_cellular_component": "GO:0044545 NSL complex;GO:0000123 histone acetyltransferase complex;GO:1902562 H4 histone acetyltransferase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5DTI6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XJE5-1", "uniprot_id": "LEO1_MOUSE", "mass": 75597.0, "length": 667, "protein_name": "RNA polymerase-associated protein LEO1", "gene_name": "Leo1", "organism": "Mouse", "refseq_name": "RNA polymerase-associated protein LEO1", "refseq_ac": "NP_001034611", "gene_names_uniprotkb": "Leo1; Gm185", "gene_names_refseq": "Gm185; Leo1", "protein_names_uniprotkb": "RNA polymerase-associated protein LEO1", "protein_names_refseq": "Leo1, Paf1/RNA polymerase II complex component, homolog; RNA polymerase-associated protein LEO1", "tax_id": 10090, "disease": "", "pathway": " (mmu:235497); (R-MMU-112382); (R-MMU-201722); (R-MMU-674695); (R-MMU-75955); (R-MMU-8866654)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17242355;17622165;19345177;21183079;27749823;27864380;34428180;39627609", "class_list": "", "function": "Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 29, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QPK8;Q640R1", "ec_number_list": "", "go_molecular_function": "GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0001650 fibrillar center;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0016055 Wnt signaling pathway;GO:0019827 stem cell population maintenance;GO:0006368 transcription elongation by RNA polymerase II;GO:0001711 endodermal cell fate commitment", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q5XJE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60843-1", "uniprot_id": "KLF2_MOUSE", "mass": 37657.0, "length": 354, "protein_name": "Krueppel-like factor 2", "gene_name": "Klf2", "organism": "Mouse", "refseq_name": "Krueppel-like factor 2", "refseq_ac": "NP_032478", "gene_names_uniprotkb": "Klf2; Lklf", "gene_names_refseq": "Klf2; Lklf", "protein_names_uniprotkb": "Krueppel-like factor 2; Lung krueppel-like factor", "protein_names_refseq": "Krueppel-like factor 2; Kruppel-like factor 2 (lung); lung krueppel-like factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:16598)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11375995;15003522;21183079;30779550;31219806;7565748", "class_list": "", "function": "Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RS60", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0097533 cellular stress response to acid chemical;GO:1990859 cellular response to endothelin;GO:0043249 erythrocyte maturation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q60843-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PAR0-1", "uniprot_id": "KLD10_MOUSE", "mass": 49012.0, "length": 439, "protein_name": "Kelch domain-containing protein 10", "gene_name": "Klhdc10", "organism": "Mouse", "refseq_name": "kelch domain-containing protein 10 isoform 2", "refseq_ac": "NP_001298016", "gene_names_uniprotkb": "Klhdc10; Kiaa0265", "gene_names_refseq": "2410127E18Rik; Klhdc10; mKIAA0265", "protein_names_uniprotkb": "Kelch domain-containing protein 10", "protein_names_refseq": "kelch domain-containing protein 10 isoform 2; kelch domain-containing protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:76788); (R-MMU-9954709)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "21750661;23102700;24129315;25428506;27631783;30084848;30779550;34203471;34428180", "class_list": "", "function": "Results suggest that KLHDC10 is a cell-type specific regulator of necroptosis that ultimately contributes to the development of TNFalpha-induced SIRS Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C-terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(KLHDC10) complex specifically recognizes proteins with a proline-glycine (Pro-Gly) or an alanine tail (CAT tail) at the C-terminus, leading to their ubiquitination and degradation (By similarity). The CRL2(KLHDC10) complex is involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: CRL2(KLHDC10) acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (By similarity). Participates in the oxidative stress-induced cell death through MAP3K5 activation (By similarity). Inhibits PPP5C phosphatase activity on MAP3K5 (PubMed:23102700). Acts as a regulator of necroptosis (PubMed:27631783)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6A095;Q8BH94;Q8BPK7;Q8C3Q4;Q8C7G4;Q9CWF4", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0016567 protein ubiquitination;GO:0032874 positive regulation of stress-activated MAPK cascade;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6PAR0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6S5J6-1", "uniprot_id": "KRIT1_MOUSE", "mass": 83982.0, "length": 736, "protein_name": "Krev interaction trapped protein 1", "gene_name": "Krit1", "organism": "Mouse", "refseq_name": "krev interaction trapped protein 1 isoform 2", "refseq_ac": "NP_001164023", "gene_names_uniprotkb": "Krit1; Ccm1", "gene_names_refseq": "2010007K12Rik; A630036P20Rik; Ccm1; Krit1", "protein_names_uniprotkb": "Krev interaction trapped protein 1; Cerebral cavernous malformations 1 protein homolog; Krev interaction trapped 1", "protein_names_refseq": "Krev interaction trapped protein 1; cerebral cavernous malformations 1 protein homolog; krev interaction trapped 1; krev interaction trapped protein 1 isoform 2", "tax_id": 10090, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); cerebral cavernous malformation 1 (Disease Ontology:DOID:0080491)", "pathway": " (mmu:79264)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11161791;12172908;12204286;14697511;19151727;20332120;20616044;20668652;21750661;22872234;25428506;25605945;26417067;30084848;34203471;34428180;36210013;38293758", "class_list": "", "function": "Cerebral cavernous malformation proteins, CCM1, CCM2 and CCM3, are decreased in metastatic lesions in a murine breast carcinoma model., [RefSeq, PubMed]; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner (By similarity). Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels. May play a role in the regulation of macroautophagy through the down-regulation of the mTOR pathway (PubMed:26417067)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Evidence of differential Krit1 and Rap1A expression during mouse ontogenesis and suggest a more widespread functional significance of Krit1, not restricted to vascular endothelial cells., [RefSeq, PubMed]; Krit1 mRNA expression during mouse development from E7.5 to E20.5 and in adult tissues, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6VSV2;Q7TPR8;Q8C9Q6;Q9EPY2;Q9ERH0", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0008017 microtubule binding;GO:0030695 GTPase regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0001937 negative regulation of endothelial cell proliferation;GO:2000352 negative regulation of endothelial cell apoptotic process;GO:0016525 negative regulation of angiogenesis;GO:0010596 negative regulation of endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q6S5J6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1G2-1", "uniprot_id": "LBN_MOUSE", "mass": 137639.0, "length": 1220, "protein_name": "Limbin", "gene_name": "Evc2", "organism": "Mouse", "refseq_name": "limbin precursor", "refseq_ac": "NP_666032", "gene_names_uniprotkb": "Evc2; Lbn", "gene_names_refseq": "1110017L09Rik; Evc2; Lbn; limbin", "protein_names_uniprotkb": "Limbin", "protein_names_refseq": "Ellis van Creveld syndrome 2 homolog; limbin precursor", "tax_id": 10090, "disease": "Weyers acrofacial dysostosis (Disease Ontology:DOID:0111571); Ellis-Van Creveld syndrome (Disease Ontology:DOID:12714)", "pathway": " (mmu:68525); (R-MMU-5632684)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;12136126;19251731;19349973;19810119;21356043;24582806;28950429;33731941", "class_list": "", "function": "By comparing neural crest-specific Evc2 mutants with control mice, study demonstrated that the abnormalities within the mid-facial regions are not accounted for by the Evc2 mutation within these regions., [RefSeq, PubMed]; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (PubMed:21356043, PubMed:24582806). Plays a critical role in bone formation and skeletal development (PubMed:21356043). May be involved in early embryonic morphogenesis (PubMed:21356043)., [UniProtKB, PubMed, PubMed]; EVC and LBN protein colocalize at the tip of the primary atrial septum during murine cardiac development., [RefSeq, PubMed]; Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution. Erratum:[Nat Genet. 2021 Apr;53(4):587. doi: 10.1038/s41588-021-00849-4. PMID: 33762754], [RefSeq, PubMed]; The expression of a Weyer variant, but not the expression of a truncated protein that mimics an Ellis-van Creveld syndrome mutation, impairs Hedgehog signal transduction in NIH 3T3 cells in keeping with its dominant effect., [RefSeq, PubMed]; We demonstrate for the first time that Evc2 is a positive regulator of the Hh signalling pathway and that it is located at the basal body of primary cilia. Evc2 is present in the cell nucleus suggesting movement of Evc2 between the cilium and nucleus. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BRF3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005929 cilium;GO:0060170 ciliary membrane;GO:0098797 plasma membrane protein complex", "go_biological_process": "GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8K1G2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KR3-1", "uniprot_id": "LACB2_MOUSE", "mass": 32754.0, "length": 288, "protein_name": "Endoribonuclease LACTB2", "gene_name": "Lactb2", "organism": "Mouse", "refseq_name": "endoribonuclease LACTB2 isoform 1", "refseq_ac": "NP_663356", "gene_names_uniprotkb": "Lactb2", "gene_names_refseq": "Cgi-83; E430032H21Rik; Lactb2", "protein_names_uniprotkb": "Endoribonuclease LACTB2; 3.1.27.-; Beta-lactamase-like protein 2", "protein_names_refseq": "beta-lactamase-like protein 2; endoribonuclease LACTB2 isoform 1; endoribonuclease LACTB2", "tax_id": 10090, "disease": "", "pathway": " (mmu:212442)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;23576753;23806337;25428506;31219806;34428180", "class_list": "", "function": "Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0003727 single-stranded RNA binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99KR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0M1-1", "uniprot_id": "KLK4_MOUSE", "mass": 27488.0, "length": 255, "protein_name": "Kallikrein-4", "gene_name": "Klk4", "organism": "Mouse", "refseq_name": "kallikrein-4 precursor", "refseq_ac": "NP_064312", "gene_names_uniprotkb": "Klk4; EMSP1; KLK-L1; Prss17", "gene_names_refseq": "ESMP1; KLK-L1; Klk4; PSTS; Prss17", "protein_names_uniprotkb": "Kallikrein-4; 3.4.21.-; Enamel matrix serine proteinase 1; Kallikrein-like protein 1; Serine protease 17", "protein_names_refseq": "enamel matrix serine proteinase 1; kallikrein-4 precursor; kallikrein-4; kallikrein-like protein 1; protease, serine 17 (enamel matrix, prostate)", "tax_id": 10090, "disease": "amelogenesis imperfecta type 2A1 (Disease Ontology:DOID:0110057); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (mmu:56640)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10690663;10863090;12206593;19578120;21285247;22243251;25428506;26495903;30059200;34781073;36929047", "class_list": "", "function": "Deficiency of G protein-coupled receptor Gpr111/Adgrf2 causes enamel hypomineralization in mice by alteration of the expression of kallikrein-related peptidase 4 (Klk4) during pH cycling process., [RefSeq, PubMed]; Expression of KLK4 correlates with the stage-associated changes in the digestion of enamel proteins, [RefSeq, PubMed]; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix., [UniProtKB, PubMed]; NaF reduces KLK4 expression by decreasing Foxo1/Runx2 expression in LS8 cells., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9JIS2", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0006508 proteolysis;GO:0022617 extracellular matrix disassembly;GO:0070166 enamel mineralization;GO:0030163 protein catabolic process;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9Z0M1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61805-1", "uniprot_id": "LBP_MOUSE", "mass": 53055.0, "length": 481, "protein_name": "Lipopolysaccharide-binding protein", "gene_name": "Lbp", "organism": "Mouse", "refseq_name": "lipopolysaccharide-binding protein precursor", "refseq_ac": "NP_032515", "gene_names_uniprotkb": "Lbp", "gene_names_refseq": "Bpifd2; Lbp; Ly88", "protein_names_uniprotkb": "Lipopolysaccharide-binding protein; LBP", "protein_names_refseq": "lipopolysaccharide-binding protein precursor", "tax_id": 10090, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); obstructive jaundice (Disease Ontology:DOID:13603); liver cirrhosis (Disease Ontology:DOID:5082); periodontitis (Disease Ontology:DOID:824); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16803); (R-MMU-166016); (R-MMU-166020); (R-MMU-5686938)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;21750661;24120359;24380872;25428506;26495903;30084848;31361958;31599954;34428180;37789385;9144073", "class_list": "", "function": "Gastric cancer-derived LBP promotes liver metastasis by driving intrahepatic fibrotic pre-metastatic niche formation. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:9144073). Acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity). Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:24380872)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2AC66;Q99KA0", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0015026 coreceptor activity;GO:0001530 lipopolysaccharide binding;GO:0071723 lipopeptide binding;GO:0070891 lipoteichoic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface", "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:0090559 regulation of membrane permeability;GO:0032496 response to lipopolysaccharide;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q61805-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLJ0-1", "uniprot_id": "LITAF_MOUSE", "mass": 16946.0, "length": 161, "protein_name": "Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog", "gene_name": "Litaf", "organism": "Mouse", "refseq_name": "lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog", "refseq_ac": "NP_064364", "gene_names_uniprotkb": "Litaf; N4wbp3; Tbx1", "gene_names_refseq": "3222402J11Rik; Litaf; N4WBP3; TBX1", "protein_names_uniprotkb": "Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; Estrogen-enhanced transcript protein; LITAF-like protein; LPS-induced TNF-alpha factor homolog; NEDD4 WW domain-binding protein 3; mEET", "protein_names_refseq": "LITAF-like protein; LPS-induced TNF-alpha factor homolog; Nedd4 WW domain-binding protein 3; estrogen-enhanced transcript protein; lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; mEET", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 1C (Disease Ontology:DOID:0110151)", "pathway": " (mmu:56722)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "11042109;12355436;15025820;15793005;16954198;18250455;21750661;21980379;22160695;22729949;23166352;25428506;26495903;26740625;27802388;28011936;28935714;31599954;32544461;33823186;34320238;34428180;35984892;37828378;37848750", "class_list": "", "function": "LITAF Promotes Atherosclerotic Plaque Formation by Stimulating the NF-kappaB Inflammatory Pathway., [RefSeq, PubMed]; LITAF acts as a novel regulator for pathological cardiac hypertrophy., [RefSeq, PubMed]; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps down-regulate downstream signaling cascades (PubMed:23166352). Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4 (By similarity). May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines (PubMed:15793005, PubMed:21980379). May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 (PubMed:12355436, PubMed:15025820, PubMed:16954198, PubMed:21980379, PubMed:22160695)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; SIMPLE Is an Endosomal Regulator That Protects Against NAFLD by Targeting the Lysosomal Degradation of EGFR., [RefSeq, PubMed]; Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQI0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0050699 WW domain binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0032496 response to lipopolysaccharide;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071222 cellular response to lipopolysaccharide;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q9JLJ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70662-1", "uniprot_id": "LDB1_MOUSE", "mass": 46503.0, "length": 411, "protein_name": "LIM domain-binding protein 1", "gene_name": "Ldb1", "organism": "Mouse", "refseq_name": "LIM domain-binding protein 1 isoform 1", "refseq_ac": "NP_001106879", "gene_names_uniprotkb": "Ldb1; Nli", "gene_names_refseq": "CLIM2; Ldb1; NLI", "protein_names_uniprotkb": "LIM domain-binding protein 1; CLIM-2; Carboxyl-terminal LIM domain-binding protein 2; LDB-1; LIM domain-binding factor CLIM2; Nuclear LIM interactor; mLdb1", "protein_names_refseq": "LIM domain-binding factor CLIM2; LIM domain-binding protein 1 isoform 1; LIM domain-binding protein 1; carboxyl-terminal LIM domain-binding protein 2; nuclear LIM interactor", "tax_id": 10090, "disease": "nail-patella syndrome (Disease Ontology:DOID:9467)", "pathway": " (mmu:16825); (R-MMU-8939236)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;10330499;10393337;11882901;12150931;12727888;15343268;16407974;16815859;18539116;19675209;21183079;21750661;23353824;31599954;32848054;36018801;8876198;8918878;9192866;9315627;9391090;9468533;9503020;9860983", "class_list": "", "function": "Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors (PubMed:8918878, PubMed:9192866). May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions (PubMed:16815859, PubMed:18539116, PubMed:8918878, PubMed:9192866, PubMed:9315627). Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1 (PubMed:12150931, PubMed:18539116, PubMed:8876198). Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression (PubMed:8918878). Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (PubMed:9391090)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Enhancer looping protein LDB1 regulates hepatocyte gene expression by cooperating with liver transcription factors., [RefSeq, PubMed]; Mouse Ldb1b lacks the ability to activate protein 4.2 promoter, which is stimulated by LMO2 and Ldb1. These findings suggest that splice isoforms of Ldb lacking LID are potential regulators of Ldb function.[lbd1], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O55204;Q1EQX2;Q71V68", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031252 cell leading edge;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0060319 primitive erythrocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045785 positive regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P70662-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTR2-1", "uniprot_id": "M3K6_MOUSE", "mass": 143055.0, "length": 1291, "protein_name": "Mitogen-activated protein kinase kinase kinase 6", "gene_name": "Map3k6", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Map3k6; Ask2; Mapkkk6; Mekk6", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 6; 2.7.11.25; Apoptosis signal-regulating kinase 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); amphetamine abuse (Disease Ontology:DOID:670)", "pathway": " (mmu:53608)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17210579;21750661;31219806;34428180;35820727", "class_list": "", "function": "Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AE93;Q0VBN3", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0004709 MAP kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007254 JNK cascade;GO:0038066 p38MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9WTR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66L42-1", "uniprot_id": "M3K10_MOUSE", "mass": 103187.0, "length": 940, "protein_name": "Mitogen-activated protein kinase kinase kinase 10", "gene_name": "Map3k10", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase 10", "refseq_ac": "NP_001277457", "gene_names_uniprotkb": "Map3k10", "gene_names_refseq": "MST; Map3k10; Mlk2", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 10; 2.7.11.25", "protein_names_refseq": "MKN28 derived nonreceptor_type; MKN28 kinase; mitogen-activated protein kinase kinase kinase 10; mixed lineage kinase 2; serine/threonine kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:269881)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18414056;19801649;21183079;21750661;24129315;30016717;31219806;35820727", "class_list": "", "function": "Activates the JUN N-terminal pathway., [UniProtKB]; Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways, [RefSeq, PubMed]; There is extensive functional redundancy between MLK1 and MLK2, and the other member of the family, MLK3, none of which are required for survival in mouse., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q80UW4", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0003714 transcription corepressor activity;GO:0043425 bHLH transcription factor binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q66L42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVL0-1", "uniprot_id": "MAAI_MOUSE", "mass": 24275.0, "length": 216, "protein_name": "Maleylacetoacetate isomerase", "gene_name": "Gstz1", "organism": "Mouse", "refseq_name": "maleylacetoacetate isomerase isoform 2", "refseq_ac": "NP_001239484", "gene_names_uniprotkb": "Gstz1; Maai", "gene_names_refseq": "GSTZ1-1; Gstz1; MAAI", "protein_names_uniprotkb": "Maleylacetoacetate isomerase; 2.5.1.18; 5.2.1.2; GSTZ1-1; Glutathione S-transferase zeta 1; MAAI", "protein_names_refseq": "glutathione S-transferase zeta 1; maleylacetoacetate isomerase isoform 2; maleylacetoacetate isomerase", "tax_id": 10090, "disease": "", "pathway": " (mmu:14874); (R-MMU-156590); (R-MMU-204174); (R-MMU-8963684)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10373324;12052898;17242355;21183079;21750661;23806337;30084848;34428180;37453647", "class_list": "", "function": "Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice reveal a glutathione-dependent nonenzymatic bypass in tyrosine catabolism, [RefSeq, PubMed]; Probable bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1, 3-diazole and maleylacetoacetate isomerase activity. Also has low glutathione peroxidase activity with t-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.20.4.2;1.8.5.1;5.3.3.-;5.3.99.2;5.2.1.2", "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0016034 maleylacetoacetate isomerase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006559 L-phenylalanine catabolic process;GO:0006572 L-tyrosine catabolic process;GO:0006749 glutathione metabolic process;GO:1990748 cellular detoxification", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9WVL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C525-1", "uniprot_id": "M21D2_MOUSE", "mass": 48477.0, "length": 428, "protein_name": "Nucleotidyltransferase MB21D2", "gene_name": "Mb21d2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mb21d2; 1600021P15Rik", "gene_names_refseq": "", "protein_names_uniprotkb": "Nucleotidyltransferase MB21D2; 2.7.7.-; Mab-21 domain-containing protein 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "17242355;21183079;21750661;25428506;34428180", "class_list": "", "function": "Probable nucleotidyltransferase that catalyzes the formation of cyclic dinucleotide second messenger in response to some unknown stimulus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U4H4", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C525-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60700-1", "uniprot_id": "M3K12_MOUSE", "mass": 96084.0, "length": 888, "protein_name": "Mitogen-activated protein kinase kinase kinase 12", "gene_name": "Map3k12", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase 12", "refseq_ac": "NP_001157115", "gene_names_uniprotkb": "Map3k12; Zpk", "gene_names_refseq": "DLK; MUK; Map3k12; Zpk", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 12; 2.7.11.25; DLK; Dual leucine zipper bearing kinase; Leucine-zipper protein kinase; MAPK-upstream kinase; MUK; Mixed lineage kinase; ZPK", "protein_names_refseq": "MAPK-upstream kinase; dual leucine zipper bearing kinase; leucine-zipper protein kinase; mitogen-activated protein kinase kinase kinase 12; mixed lineage kinase; zipper (leucine) protein kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:26404)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21183079;21750661;25802931;28111074;31219806;7983011;8663324;8769565", "class_list": "", "function": "Protein kinase which is part of a non-canonical MAPK signaling pathway (PubMed:28111074, PubMed:7983011, PubMed:8663324). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P70286;Q3TLL7;Q8C4N7;Q8CBX3;Q8CDL6", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030426 growth cone", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0043687 post-translational protein modification;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007254 JNK cascade;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q60700-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0S2-1", "uniprot_id": "LHX2_MOUSE", "mass": 44419.0, "length": 406, "protein_name": "LIM/homeobox protein Lhx2", "gene_name": "Lhx2", "organism": "Mouse", "refseq_name": "LIM/homeobox protein Lhx2 isoform a", "refseq_ac": "NP_034840", "gene_names_uniprotkb": "Lhx2", "gene_names_refseq": "LH2A; Lh-2; Lhx2; Lim2; apterous; ap", "protein_names_uniprotkb": "LIM/homeobox protein Lhx2; Homeobox protein LH-2; LIM homeobox protein 2", "protein_names_refseq": "LIM homeo box protein 2; LIM/homeobox protein Lhx2 isoform a; LIM/homeobox protein Lhx2; homeobox protein LH-2", "tax_id": 10090, "disease": "depressive disorder (Disease Ontology:DOID:1596); congenital nystagmus (Disease Ontology:DOID:9649); pathologic nystagmus (Disease Ontology:DOID:9650)", "pathway": " (mmu:16870)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10051612;10593900;21750661;24643061", "class_list": "", "function": "Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z0S2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19973-1", "uniprot_id": "LSP1_MOUSE", "mass": 36714.0, "length": 330, "protein_name": "Lymphocyte-specific protein 1", "gene_name": "Lsp1", "organism": "Mouse", "refseq_name": "lymphocyte-specific protein 1 isoform 1", "refseq_ac": "NP_001129543", "gene_names_uniprotkb": "Lsp1; Pp52; S37; Wp34", "gene_names_refseq": "Lsp-1; Lsp1; WP34; p50; pp52", "protein_names_uniprotkb": "Lymphocyte-specific protein 1; 52 kDa phosphoprotein; Lymphocyte-specific antigen WP34; S37 protein; pp52", "protein_names_refseq": "52 kDa phosphoprotein; S37 protein; leukocyte specific protein 1; lymphocyte-specific antigen WP34; lymphocyte-specific protein 1 isoform 1; lymphocyte-specific protein 1", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:16985)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "17242355;17481585;19224205;20173027;21183079;21750661;26495903;27555448;28011936;3263441;33470457;34428180;35390317;35820727;38254711;7775393;7935501;8340356;8417117;8537319;8838798", "class_list": "", "function": "LSP1-myosin1e bimolecular complex regulates focal adhesion dynamics and cell migration., [RefSeq, PubMed]; Lymphocyte-Specific Protein 1 Regulates Expression and Stability of Endothelial Nitric Oxide Synthase. Publication Status: Online-Only, [RefSeq, PubMed]; Lymphocyte-Specific Protein-1 Suppresses Xenobiotic-Induced Constitutive Androstane Receptor and Subsequent Yes-Associated Protein-Activated Hepatocyte Proliferation., [RefSeq, PubMed]; May play a role in mediating neutrophil activation and chemotaxis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A6J5;A2A6J6;P97339;Q04950;Q62022;Q62023;Q62024;Q8CD28;Q99L65", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0006952 defense response;GO:0007165 signal transduction;GO:0006915 apoptotic process;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P19973-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80XI6-1", "uniprot_id": "M3K11_MOUSE", "mass": 93226.0, "length": 850, "protein_name": "Mitogen-activated protein kinase kinase kinase 11", "gene_name": "Map3k11", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase 11 isoform 1", "refseq_ac": "NP_071295", "gene_names_uniprotkb": "Map3k11; Mlk3", "gene_names_refseq": "2610017K16Rik; Map3k11; Mlk3; PTK1; SPRK", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 11; 2.7.11.25; Mixed lineage kinase 3", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase 11 isoform 1; mixed lineage kinase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:26403); (R-MMU-5673000); (R-MMU-9013408); (R-MMU-9013424)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10894943;19144319;21183079;21750661;23963642;34324442;34428180;35247112;35867711;36142785", "class_list": "", "function": "Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle (By similarity)., [UniProtKB]; MLK3 Regulates Inflammatory Response via Activation of AP-1 Pathway in HEK293 and RAW264.7 Cells. Publication Status: Online-Only, [RefSeq, PubMed]; MLK3 mediates impact of PKG1alpha on cardiac function and controls blood pressure through separate mechanisms. Publication Status: Online-Only, [RefSeq, PubMed]; Mixed lineage kinase 3 requires a functional CRIB domain for regulation of blood pressure, cardiac hypertrophy, and left ventricular function., [RefSeq, PubMed]; Silence of MLK3 alleviates lipopolysaccharide-induced lung epithelial cell injury via inhibiting p53-mediated ferroptosis., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0M8;Q9JJ15", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;3.6.5.2;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;3.4.19.12;2.3.1.-;2.7.10.1;2.7.11.31;3.6.5.-;2.3.2.27;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;2.1.2.1;7.1.1.2;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150;3.1.4.4", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0031434 mitogen-activated protein kinase kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0034451 centriolar satellite", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0043065 positive regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0000165 MAPK cascade;GO:0007254 JNK cascade", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q80XI6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BLK3-1", "uniprot_id": "LSAMP_MOUSE", "mass": 38086.0, "length": 341, "protein_name": "Limbic system-associated membrane protein", "gene_name": "Lsamp", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Lsamp", "gene_names_refseq": "", "protein_names_uniprotkb": "Limbic system-associated membrane protein; LSAMP", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-163125)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;18034455;21750661;30899004;33300544", "class_list": "", "function": "Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hippocampal mossy fiber projection (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0042734 presynaptic membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0051963 regulation of synapse assembly;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0035641 locomotory exploration behavior;GO:0003007 heart morphogenesis;GO:0055013 cardiac muscle cell development", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q8BLK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C8U0-1", "uniprot_id": "LIPB1_MOUSE", "mass": 108540.0, "length": 969, "protein_name": "Liprin-beta-1", "gene_name": "Ppfibp1", "organism": "Mouse", "refseq_name": "liprin-beta-1 isoform 1", "refseq_ac": "NP_001163904", "gene_names_uniprotkb": "Ppfibp1; Kiaa1230", "gene_names_refseq": "4632409B19Rik; Ppfibp1", "protein_names_uniprotkb": "Liprin-beta-1; PTPRF-interacting protein-binding protein 1; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1", "protein_names_refseq": "PTPRF-interacting protein-binding protein 1; liprin-beta-1 isoform 1; liprin-beta-1; protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67533); (R-MMU-388844)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11836260;17242355;19131326;19144319;21183079;21750661;25428506;28528544;30084848;31599954;34428180;36210013", "class_list": "", "function": "May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A (By similarity)., [UniProtKB, UniProtKB]; New molecular target of the S100A4 protein, liprin beta1, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZN5;Q6GQV3;Q80VB4;Q9CUT7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0048786 presynaptic active zone", "go_biological_process": "GO:0007528 neuromuscular junction development;GO:0043622 cortical microtubule organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8C8U0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922B1-1", "uniprot_id": "MACD1_MOUSE", "mass": 35295.0, "length": 323, "protein_name": "ADP-ribose glycohydrolase MACROD1", "gene_name": "Macrod1", "organism": "Mouse", "refseq_name": "ADP-ribose glycohydrolase MACROD1 isoform 1", "refseq_ac": "NP_598908", "gene_names_uniprotkb": "Macrod1; Lrp16", "gene_names_refseq": "D930010J01Rik; Lrp16; Macrod1", "protein_names_uniprotkb": "ADP-ribose glycohydrolase MACROD1; 3.1.1.106; 3.2.2.-; MACRO domain-containing protein 1; O-acetyl-ADP-ribose deacetylase MACROD1; Protein LRP16; [Protein ADP-ribosylaspartate] hydrolase MACROD1; [Protein ADP-ribosylglutamate] hydrolase MACROD1", "protein_names_refseq": "ADP-ribose glycohydrolase MACROD1 isoform 1; ADP-ribose glycohydrolase MACROD1; MACRO domain containing 1; MACRO domain-containing protein 1; O-acetyl-ADP-ribose deacetylase MACROD1; [Protein ADP-ribosylaspartate] hydrolase MACROD1; [Protein ADP-ribosylglutamate] hydrolase MACROD1; [Protein ADP-ribosylglutamate] hydrolase", "tax_id": 10090, "disease": "", "pathway": " (mmu:107227)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21756814;22528219;22800886;23389992;23576753;23806337;33578760;36288343;37507081;39927985", "class_list": "", "function": "Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice. Publication Status: Online-Only, [RefSeq, PubMed]; LRP16 acts as a negative regulator of insulin action and adipogenesis in 3T3-L1 adipocytes., [RefSeq, PubMed]; LRP16 gene causes insulin resistance in C2-C12 cells by inhibiting the IRS-1 signaling and the transcriptional activity of PPARgamma., [RefSeq, PubMed]; LRP16 played important roles not only in insulin content and GSIS but also in the antilipotoxic effect mediated by Akt/FoxO1 signaling., [RefSeq, PubMed]; Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity., [UniProtKB, UniProtKB]; These results suggest that LRP16 plays a key role in maintaining pancreatic beta-cell functions and may help us to understand the protective effects of estrogen on the functions of pancreatic beta-cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.2.2.19;3.5.1.-;3.2.2.-;3.2.1.143;3.1.1.106", "go_molecular_function": "GO:0019213 deacetylase activity;GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0061463 O-acetyl-ADP-ribose deacetylase activity;GO:0140293 ADP-ribosylglutamate hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006974 DNA damage response;GO:0051725 protein de-ADP-ribosylation;GO:0042278 purine nucleoside metabolic process;GO:0140291 peptidyl-glutamate ADP-deribosylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q922B1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0E3-1", "uniprot_id": "LYSM1_MOUSE", "mass": 24814.0, "length": 226, "protein_name": "LysM and putative peptidoglycan-binding domain-containing protein 1", "gene_name": "Lysmd1", "organism": "Mouse", "refseq_name": "lysM and putative peptidoglycan-binding domain-containing protein 1", "refseq_ac": "NP_694761", "gene_names_uniprotkb": "Lysmd1", "gene_names_refseq": "2610022K04Rik; Lysmd1", "protein_names_uniprotkb": "LysM and putative peptidoglycan-binding domain-containing protein 1", "protein_names_refseq": "lysM and putative peptidoglycan-binding domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:217779)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;34428180;36210013", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D0E3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QUI1-1", "uniprot_id": "LRA25_MOUSE", "mass": 20140.0, "length": 189, "protein_name": "Leucine repeat adapter protein 25", "gene_name": "Fam89b", "organism": "Mouse", "refseq_name": "leucine repeat adapter protein 25 isoform 1", "refseq_ac": "NP_852117", "gene_names_uniprotkb": "Fam89b; C184m; Lrap25; Mtvr2", "gene_names_refseq": "1110021A21Rik; Fam89b; MMTV; Mtvr2", "protein_names_uniprotkb": "Leucine repeat adapter protein 25; C184L ORF2 protein; C184M protein; MMTV receptor", "protein_names_refseq": "C184L ORF2 protein; C184M protein; MMTV receptor; leucine repeat adapter protein 25 isoform 1; leucine repeat adapter protein 25; mammary tumor virus receptor 2; protein FAM89B", "tax_id": 10090, "disease": "", "pathway": " (mmu:17826)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10512749;12646588;21183079;25107909;31219806;36808257;9525630", "class_list": "", "function": "(Microbial infection) May be a receptor for mouse mammary tumor virus (MMTV)., [UniProtKB, PubMed]; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta (PubMed:12646588). Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (PubMed:25107909)., [UniProtKB, PubMed, PubMed]; Rank ectopic expression in the presence of Neu and MMTV oncogenes alters mammary epithelial cell populations and their tumorigenic potential. Erratum:[J Mammary Gland Biol Neoplasia. 2023 Mar 7;28(1):4. doi: 10.1007/s10911-023-09532-2. PMID: 36929445] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2S5;Q9JHD8;Q9JL54", "ec_number_list": "", "go_molecular_function": "GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0030027 lamellipodium", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030010 establishment of cell polarity;GO:0060392 negative regulation of SMAD protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QUI1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZ04-1", "uniprot_id": "MAGL2_MOUSE", "mass": 137987.0, "length": 1284, "protein_name": "MAGE-like protein 2", "gene_name": "Magel2", "organism": "Mouse", "refseq_name": "MAGE-like protein 2", "refseq_ac": "NP_038807", "gene_names_uniprotkb": "Magel2", "gene_names_refseq": "Mage-l2; Magel2; NDNL1; nM15; ns7", "protein_names_uniprotkb": "MAGE-like protein 2; Protein nS7", "protein_names_refseq": "MAGE-like protein 2; melanoma antigen, family L, 2; melanoma antigen-like gene 2; necdin-like 1; protein nS7", "tax_id": 10090, "disease": "Schaaf-Yang syndrome (Disease Ontology:DOID:0111715); Prader-Willi syndrome (Disease Ontology:DOID:11983)", "pathway": " (mmu:27385)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10556298;10915770;17728320;22208286;34203471;34428180;40885482", "class_list": "", "function": "Magel2 gene is imprinted, with preferential expression from the paternal allele in mouse and human., [RefSeq, PubMed]; Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK (PubMed:22208286)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "F8WIA8", "ec_number_list": "", "go_molecular_function": "GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0042752 regulation of circadian rhythm;GO:0048511 rhythmic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QZ04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21440-1", "uniprot_id": "MDR3_MOUSE", "mass": 140377.0, "length": 1276, "protein_name": "Phosphatidylcholine translocator ABCB4", "gene_name": "Abcb4", "organism": "Mouse", "refseq_name": "phosphatidylcholine translocator ABCB4", "refseq_ac": "NP_032856", "gene_names_uniprotkb": "Abcb4; Mdr2; Pgy-2; Pgy2", "gene_names_refseq": "Abcb4; Mdr2; Pgy-2; Pgy2; mdr-2", "protein_names_uniprotkb": "Phosphatidylcholine translocator ABCB4; 7.6.2.1; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 2; Multidrug resistance protein 3; P-glycoprotein 2; P-glycoprotein 3", "protein_names_refseq": "ATP-binding cassette, sub-family B (MDR/TAP), member 4; P glycoprotein 2; P-glycoprotein 3; multidrug resistance protein 2; multidrug resistance protein 3; phosphatidylcholine translocator ABCB4", "tax_id": 10090, "disease": "primary sclerosing cholangitis (Disease Ontology:DOID:0060643); progressive familial intrahepatic cholestasis 3 (Disease Ontology:DOID:0070223); intrahepatic cholestasis of pregnancy 3 (Disease Ontology:DOID:0070229); primary biliary cholangitis (Disease Ontology:DOID:12236); cholestasis (Disease Ontology:DOID:13580); cystic fibrosis (Disease Ontology:DOID:1485); intrahepatic cholestasis (Disease Ontology:DOID:1852); cholecystitis (Disease Ontology:DOID:1949); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:18670); (R-MMU-382556)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "12381268;1381362;1969609;1990275;21183079;21750661;21820390;23468132;2471060;3405218;34428180;7592705;7814632;7912658;8106172;8615769;8725158;8759018;9366571", "class_list": "", "function": "Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi between hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7592705, PubMed:7814632, PubMed:7912658, PubMed:8106172, PubMed:8725158, PubMed:9366571). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (By similarity). Required for proper phospholipid bile formation (PubMed:8106172). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:7814632, PubMed:8725158). May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (PubMed:1990275)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EK77;Q6LCL9", "ec_number_list": "7.6.2.1;7.6.2.2;7.6.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0090554 phosphatidylcholine floppase activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0055088 lipid homeostasis;GO:0045332 phospholipid translocation;GO:0061092 positive regulation of phospholipid translocation;GO:0032376 positive regulation of cholesterol transport;GO:0032782 bile acid secretion", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P21440-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63844-1", "uniprot_id": "MK03_MOUSE", "mass": 43066.0, "length": 380, "protein_name": "Mitogen-activated protein kinase 3", "gene_name": "Mapk3", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase 3", "refseq_ac": "NP_036082", "gene_names_uniprotkb": "Mapk3; Erk1; Prkm3", "gene_names_refseq": "Erk-1; Erk1; Ert2; Esrk1; Mapk3; Mnk1; Mtap2k; Prkm3; p44erk1; p44mapk; p44", "protein_names_uniprotkb": "Mitogen-activated protein kinase 3; 2.7.11.24; ERK-1; ERT2; Extracellular signal-regulated kinase 1; Insulin-stimulated MAP2 kinase; MAP kinase 3; MAP kinase isoform p44; MAPK 3; MNK1; Microtubule-associated protein 2 kinase; p44-ERK1; p44-MAPK", "protein_names_refseq": "MAP kinase 3; extracellular signal-regulated kinase 1; insulin-stimulated MAP2 kinase; microtubule-associated protein 2 kinase; mitogen-activated protein kinase 3; p44 MAP kinase; pp42/MAP kinase", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); withdrawal disorder (Disease Ontology:DOID:0060001); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); gastric ulcer (Disease Ontology:DOID:10808); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); colon adenocarcinoma (Disease Ontology:DOID:234); morphine dependence (Disease Ontology:DOID:2560); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometrial carcinoma (Disease Ontology:DOID:2871); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419); pulmonary hypertension (Disease Ontology:DOID:6432); cocaine abuse (Disease Ontology:DOID:809); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:26417); (R-MMU-110056); (R-MMU-112409); (R-MMU-1169408); (R-MMU-1181150); (R-MMU-1295596); (R-MMU-1502540); (R-MMU-162658); (R-MMU-170968); (R-MMU-198753); (R-MMU-202670); (R-MMU-2029482); (R-MMU-2173795); (R-MMU-2173796); (R-MMU-2559580); (R-MMU-2559582); (R-MMU-2559585); (R-MMU-2871796); (R-MMU-3371453); (R-MMU-375165); (R-MMU-445144); (R-MMU-450341); (R-MMU-456926); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5654732); (R-MMU-5654733); (R-MMU-5663213); (R-MMU-5668599); (R-MMU-5673001); (R-MMU-5674135); (R-MMU-5674499); (R-MMU-5675221); (R-MMU-6811558); (R-MMU-73728); (R-MMU-74749); (R-MMU-877300); (R-MMU-881907); (R-MMU-8939211); (R-MMU-9627069); (R-MMU-9732724); (R-MMU-982772); (R-MMU-9856649)", "pathway_count": 43, "publication_count": 36, "publication_id_list": "10080542;11090077;11684667;11702783;11726647;11841548;12134156;1459009;15118098;15314156;15383658;15899793;15923189;16162500;16393692;1716439;1717989;17947660;18034455;19131326;19144319;19565474;20173027;21183079;21262971;21750661;21779493;22872234;25605945;28986096;30084848;30779550;34428180;35820727;8424957;8444355", "class_list": "", "function": "Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DEPTOR, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Phosphorylates GJA1 at 'Ser-279' and 'Ser-282' resulting in an increase in GJA1 ubiquitination and ultimately lysosomal degradation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61531;Q8K0X5;Q91YW5", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;3.1.3.16;3.1.3.48;3.2.1.31;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.10.1;3.6.4.10;2.7.11.26;2.7.11.19;2.7.11.17;3.6.5.2;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;5.2.1.8;2.7.10.4;2.7.1.153;2.7.1.137;2.7.1.40;2.3.2.24;2.3.2.23;2.7.11.21;3.6.4.-;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.2.27;6.3.2.n3;3.1.4.11;6.1.1.10;3.6.4.13;2.3.1.48;4.1.1.32;6.1.1.4;6.1.1.18;6.1.1.5;3.4.22.62;2.7.11.38;6.1.1.12;3.6.1.-;2.7.7.-;6.1.1.6;3.6.-.-;6.1.1.19;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;5.3.99.3;3.4.19.12;2.3.2.31;2.7.1.150", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0072584 caveolin-mediated endocytosis;GO:2000641 regulation of early endosome to late endosome transport;GO:0030878 thyroid gland development;GO:0070498 interleukin-1-mediated signaling pathway;GO:0000045 autophagosome assembly", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q63844-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A9R3-1", "uniprot_id": "MAGB4_MOUSE", "mass": 60922.0, "length": 556, "protein_name": "Melanoma-associated antigen B4", "gene_name": "Mageb4", "organism": "Mouse", "refseq_name": "melanoma-associated antigen B4", "refseq_ac": "NP_001028664", "gene_names_uniprotkb": "Mageb4", "gene_names_refseq": "Mage-b4; Mageb4; mMage-b4", "protein_names_uniprotkb": "Melanoma-associated antigen B4", "protein_names_refseq": "melanoma antigen, family B, 4; melanoma-associated antigen B4", "tax_id": 10090, "disease": "", "pathway": " (mmu:434903)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10706124;21183079;37451217", "class_list": "", "function": "MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZWI9;Q3UNA3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2A9R3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8C6-1", "uniprot_id": "MED11_MOUSE", "mass": 13131.0, "length": 117, "protein_name": "Mediator of RNA polymerase II transcription subunit 11", "gene_name": "Med11", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 11", "refseq_ac": "NP_079673", "gene_names_uniprotkb": "Med11; MED11", "gene_names_refseq": "1110030J09Rik; Med11", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 11; Mediator complex subunit 11", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 11; mediator of RNA polymerase II transcription, subunit 11 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66172)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;36001086", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V4D0", "ec_number_list": "", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000151 ubiquitin ligase complex;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0016567 protein ubiquitination;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D8C6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34884-1", "uniprot_id": "MIF_MOUSE", "mass": 12504.0, "length": 115, "protein_name": "Macrophage migration inhibitory factor", "gene_name": "Mif", "organism": "Mouse", "refseq_name": "macrophage migration inhibitory factor", "refseq_ac": "NP_034928", "gene_names_uniprotkb": "Mif", "gene_names_refseq": "DER6; GIF; Glif; Mif", "protein_names_uniprotkb": "Macrophage migration inhibitory factor; 5.3.2.1; 5.3.3.12; DER6; Delayed early response protein 6; GIF; Glycosylation-inhibiting factor; L-dopachrome isomerase; L-dopachrome tautomerase; MIF; Phenylpyruvate tautomerase", "protein_names_refseq": "L-dopachrome isomerase; L-dopachrome tautomerase; delayed early response protein 6; macrophage migration inhibitory factor; phenylpyruvate tautomerase", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); alcohol-associated liver disease (Disease Ontology:DOID:0070658); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); hypertension (Disease Ontology:DOID:10763); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); allergic disease (Disease Ontology:DOID:1205); toxic shock syndrome (Disease Ontology:DOID:14115); cystic fibrosis (Disease Ontology:DOID:1485); cystitis (Disease Ontology:DOID:1679); epilepsy (Disease Ontology:DOID:1826); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); hamartoma (Disease Ontology:DOID:3462); retinitis (Disease Ontology:DOID:3612); lung non-small cell carcinoma (Disease Ontology:DOID:3908); rhinitis (Disease Ontology:DOID:4483); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); borna disease (Disease Ontology:DOID:5154); pneumonia (Disease Ontology:DOID:552); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); myocarditis (Disease Ontology:DOID:820); lung disease (Disease Ontology:DOID:850); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:17319); (R-MMU-202733); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 24, "publication_id_list": "10360941;10933783;1508193;16075062;16780921;17526494;19188446;23806337;26495903;28011936;31219806;33725478;34428180;36288343;37507081;37828378;39416784;7558020;7558021;7679497;7706726;7947826;8234256;8413654", "class_list": "", "function": "Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens (By similarity). The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense (By similarity). Counteracts the anti-inflammatory activity of glucocorticoids (By similarity). Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known (PubMed:10933783, PubMed:16780921, PubMed:19188446). It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (PubMed:10933783, PubMed:16780921, PubMed:19188446)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; The role of PAR2 in regulating MIF release in house dust mite-induced atopic dermatitis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 29, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.25;3.2.1.33;3.5.4.6;1.11.1.24;3.4.22.52;3.4.19.12;3.4.22.27;1.1.1.42;3.4.21.46;4.1.2.13;5.3.1.9;5.1.3.-;3.6.4.10;2.4.2.7;1.16.3.1;3.6.5.-;4.2.1.24;3.4.22.1;3.2.1.31;2.7.1.11;2.7.10.2;5.2.1.8;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;5.3.3.12;5.3.2.1;3.4.24.35;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;1.11.1.7;3.1.6.12;2.7.11.1;2.7.1.40;3.5.4.5;3.4.25.1;2.7.11.39;2.7.4.6;2.7.13.3;3.6.4.6;2.7.1.1;2.7.1.-;3.1.1.47;3.6.4.13;2.7.11.22;2.7.11.23;2.3.2.26;5.4.2.2;5.4.2.7;2.3.2.27;3.1.6.14;2.7.1.35;3.4.19.1;3.6.1.6;2.3.3.8;4.1.2.4;2.3.2.5;5.4.2.11;5.4.2.4;2.4.1.1;2.4.1.186;3.4.18.1;3.5.1.23;3.5.1.-", "go_molecular_function": "GO:0002020 protease binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0010629 negative regulation of gene expression;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P34884-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C1S0-1", "uniprot_id": "MED19_MOUSE", "mass": 26263.0, "length": 244, "protein_name": "Mediator of RNA polymerase II transcription subunit 19", "gene_name": "Med19", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 19", "refseq_ac": "NP_080161", "gene_names_uniprotkb": "Med19", "gene_names_refseq": "2410018M14Rik; 3110040A13Rik; LCMR1; Med19", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 19; Mediator complex subunit 19", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 19; mediator of RNA polymerase II transcription, subunit 19 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:381379)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;31219806;34428180", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80XM2;Q8R3G3", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C1S0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2D6-1", "uniprot_id": "MECP2_MOUSE", "mass": 52307.0, "length": 484, "protein_name": "Methyl-CpG-binding protein 2", "gene_name": "Mecp2", "organism": "Mouse", "refseq_name": "methyl-CpG-binding protein 2 isoform 1", "refseq_ac": "NP_001075448", "gene_names_uniprotkb": "Mecp2", "gene_names_refseq": "1500041B07Rik; D630021H01Rik; Mbd5; Mecp2; WBP10", "protein_names_uniprotkb": "Methyl-CpG-binding protein 2; MeCp-2 protein; MeCp2", "protein_names_refseq": "meCp-2 protein; methyl-CpG-binding protein 2 isoform 1", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); syndromic X-linked intellectual disability Lubs type (Disease Ontology:DOID:0060799); X-linked intellectual disability-psychosis-macroorchidism syndrome (Disease Ontology:DOID:0060827); severe congenital encephalopathy due to MECP2 mutation (Disease Ontology:DOID:0111932); Rett syndrome (Disease Ontology:DOID:1206); autistic disorder (Disease Ontology:DOID:12849); transient cerebral ischemia (Disease Ontology:DOID:224); hepatocellular carcinoma (Disease Ontology:DOID:684); gastrointestinal system disease (Disease Ontology:DOID:77)", "pathway": " (mmu:17257)", "pathway_count": 1, "publication_count": 33, "publication_id_list": "10369871;15034150;17046689;17296936;19820693;20711186;21183079;21750661;21765426;22517741;22645316;23055506;23434322;23770565;23806337;24129315;24671997;25420914;26192747;26842955;28116477;28348241;29097744;31352003;32138755;32848054;33551790;34773221;35822049;40021952;40885482;9171351;9774669", "class_list": "", "function": "Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B1AUZ2;B1AUZ3;Q3TYG1", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003729 mRNA binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure;GO:1903861 positive regulation of dendrite extension;GO:0006020 inositol metabolic process;GO:0001964 startle response;GO:0051707 response to other organism", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q9Z2D6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70661-1", "uniprot_id": "NGN3_MOUSE", "mass": 23267.0, "length": 214, "protein_name": "Neurogenin-3", "gene_name": "Neurog3", "organism": "Mouse", "refseq_name": "neurogenin-3", "refseq_ac": "NP_033849", "gene_names_uniprotkb": "Neurog3; Ath4b; Atoh5; Ngn3", "gene_names_refseq": "Atoh5; Math4B; Neurog3; bHLHa7; ngn3", "protein_names_uniprotkb": "Neurogenin-3; Helix-loop-helix protein mATH-4B; NGN-3; Protein atonal homolog 5; mATH4B", "protein_names_refseq": "Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B); helix-loop-helix protein mATH-4B; neurogenin-3; protein atonal homolog 5", "tax_id": 10090, "disease": "congenital malabsorptive diarrhea 4 (Disease Ontology:DOID:0060779); glucose intolerance (Disease Ontology:DOID:10603); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:11925)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10677506;18560595;19759004;21750661;9000438;9108377", "class_list": "", "function": "Is a transcriptional regulator involved in the control of enteroendocrine cell differentiation. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0003690 double-stranded DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0021510 spinal cord development;GO:0030855 epithelial cell differentiation;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70661-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97305-1", "uniprot_id": "NFAC3_MOUSE", "mass": 115451.0, "length": 1075, "protein_name": "Nuclear factor of activated T-cells, cytoplasmic 3", "gene_name": "Nfatc3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nfatc3; Nfat4", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear factor of activated T-cells, cytoplasmic 3; NF-ATc3; NFATc3; NFATx; T-cell transcription factor NFAT4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-2025928); (R-MMU-2871809); (R-MMU-5607763)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10089876;12370307;12750314;17198697;17579027;19538478;20495147;21183079;21514407;21525433;24970700;25215946;31219806;34428180;7650004;9017603", "class_list": "", "function": "Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (PubMed:21514407). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (PubMed:21514407). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (PubMed:20495147, PubMed:21525433). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (PubMed:20495147, PubMed:21525433). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (PubMed:19538478). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (PubMed:12750314). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (By similarity). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (PubMed:17579027). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (PubMed:24970700). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60896", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0014904 myotube cell development;GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation;GO:0007507 heart development;GO:0043065 positive regulation of apoptotic process;GO:0045429 positive regulation of nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P97305-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6WKZ7-1", "uniprot_id": "NOSTN_MOUSE", "mass": 57673.0, "length": 506, "protein_name": "Nostrin", "gene_name": "Nostrin", "organism": "Mouse", "refseq_name": "nostrin", "refseq_ac": "NP_853525", "gene_names_uniprotkb": "Nostrin; Daip2", "gene_names_refseq": "Daip2; Nostrin; mDaIP2", "protein_names_uniprotkb": "Nostrin; Dab2-interacting protein 2; Disabled homolog 2-interacting protein 2; Nitric oxide synthase trafficker; eNOS-trafficking inducer", "protein_names_refseq": "Dab2-interacting protein 2; disabled homolog 2-interacting protein 2; eNOS-trafficking inducer; nostrin; probable ortholog of human nitric oxide synthase trafficker (NOSTRIN)", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061)", "pathway": " (mmu:329416); (R-MMU-203641)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "15596140;16171775;17242355;19144319;21183079;21183735;22751148;24361894;26169369;28235804;30084848;34428180;36210013", "class_list": "", "function": "Mouse NOSTRIN acts as a transcriptional repressor by binding to the cis-element through its bZIP motif., [RefSeq, PubMed]; Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane., [UniProtKB, PubMed]; NOSTRIN is crucial for the localization and function of the muscarinic M3 receptor at the plasma membrane in the aorta., [RefSeq, PubMed]; NOSTRIN participates in FGF signal transduction and vascular development., [RefSeq, PubMed]; Results reveal an elegant mechanism of eNOS regulation by PECAM-1 through signal transducers and activators of transcription 3-mediated transcriptional control of NOSTRIN., [RefSeq, PubMed]; Shares 82% identity with human NOSTRIN; functions in a different fashion from NOSTRIN and its function may be concerted with that of disabled 2(disabled 2 interacting protein 2), [RefSeq, PubMed]; The SH3 domain of NOSTRIN is involved in the NOSTRIN-TRAF6 interaction and is required for NOSTRIN-induced down-regulation of endothelial cell proteins, [RefSeq, PubMed]; The disabled 2 interacting protein 2 represses the expression of its own gene, via a feedback mechanism which involves binding to the promoter region., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSK5;Q8BWC2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6WKZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZQ12-3", "uniprot_id": "NINL_MOUSE", "mass": 157838.0, "length": 1394, "protein_name": "Ninein-like protein", "gene_name": "Ninl", "organism": "Mouse", "refseq_name": "ninein-like protein", "refseq_ac": "NP_997087", "gene_names_uniprotkb": "Ninl; Kiaa0980; Nlp", "gene_names_refseq": "4930519N13Rik; Gm1004; Gm1634; Ninl; mKIAA0980", "protein_names_uniprotkb": "Ninein-like protein", "protein_names_refseq": "ninein-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:78177); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "21183079;25428506;30084848", "class_list": "", "function": "Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly (By similarity). Involved in vesicle transport in photoreceptor cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2ANB8;Q6NXH6", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0034454 microtubule anchoring at centrosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6ZQ12-3", "record_type": "protein" }, { "uniprot_canonical_ac": "P50136-1", "uniprot_id": "ODBA_MOUSE", "mass": 50371.0, "length": 442, "protein_name": "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial", "gene_name": "Bckdha", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Bckdha", "gene_names_refseq": "", "protein_names_uniprotkb": "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; 1.2.4.4; BCKDE1A; BCKDH E1-alpha; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain", "protein_names_refseq": "", "tax_id": 10090, "disease": "maple syrup urine disease type IA (Disease Ontology:DOID:0061203); maple syrup urine disease (Disease Ontology:DOID:9269)", "pathway": " (R-MMU-70895); (R-MMU-9859138)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "17208939;17242355;19144319;21183079;21750661;23576753;23806337;34428180;36288343;37453647;8761456", "class_list": "", "function": "Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.1.4;2.7.11.-;2.7.11.1;2.7.11.4;1.2.4.4;2.3.1.168;3.1.3.16;3.1.3.52", "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0003863 branched-chain 2-oxo acid dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0160157 branched-chain alpha-ketoacid dehydrogenase complex", "go_biological_process": "GO:0009083 branched-chain amino acid catabolic process;GO:0120552 branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P50136-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35486-1", "uniprot_id": "ODPA_MOUSE", "mass": 43232.0, "length": 390, "protein_name": "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial", "gene_name": "Pdha1", "organism": "Mouse", "refseq_name": "pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor", "refseq_ac": "NP_032836", "gene_names_uniprotkb": "Pdha1; Pdha-1", "gene_names_refseq": "Pdha-1; Pdha1", "protein_names_uniprotkb": "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; 1.2.4.1; PDHE1-A type I", "protein_names_refseq": "PDHE1-A type I; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; pyruvate dehydrogenase E1alpha subunit", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:18597); (R-MMU-204174); (R-MMU-5362517); (R-MMU-9837999); (R-MMU-9861559)", "pathway_count": 5, "publication_count": 25, "publication_id_list": "11708858;1581363;17208939;17242355;17314311;18034455;18586888;18630941;19144319;19341700;20841503;21183079;23576753;23806337;23835326;26848621;29263907;31219806;33300544;34428180;35820727;36288343;37507081;38420800;39927985", "class_list": "", "function": "PPP3CB Inhibits Cell Proliferation and the Warburg Effect in Bladder Cancer by Blocking PDHK1., [RefSeq, PubMed]; Together with PDHB forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex. The PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) (By similarity). The E1 subunit catalyzes both the thiamine pyrophosphate (TPP)-dependent decarboxylation of pyruvate and the reductive acetylation of a lipoyl group covalently linked to the lipoyl-bearing domains of E2 (PubMed:11708858, PubMed:20841503)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.3.1;1.8.1.4;5.3.3.21;3.1.2.-;3.1.2.2;2.7.11.2;2.7.11.-;3.4.21.92;1.1.1.37;4.98.1.1;1.2.4.1;3.6.4.10;5.3.3.8;1.2.1.3;1.1.1.42;7.1.2.2;5.6.1.7;4.2.1.2;3.1.3.43;1.2.4.2;1.1.1.35;1.1.1.30;2.3.1.12;2.3.1.9;2.3.1.37;7.1.1.2;1.1.1.38;4.2.1.3;1.2.1.36;1.7.1.-;1.2.1.28;2.3.3.1;2.8.3.5;2.3.1.41;1.1.1.41;1.3.8.5;6.2.1.-;6.2.1.4", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0043209 myelin sheath;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006006 glucose metabolic process;GO:0006086 pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P35486-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHJ5-1", "uniprot_id": "TBL1R_MOUSE", "mass": 55661.0, "length": 514, "protein_name": "F-box-like/WD repeat-containing protein TBL1XR1", "gene_name": "Tbl1xr1", "organism": "Mouse", "refseq_name": "F-box-like/WD repeat-containing protein TBL1XR1", "refseq_ac": "NP_109657", "gene_names_uniprotkb": "Tbl1xr1; Ira1; Tblr1", "gene_names_refseq": "8030499H02Rik; A630076E03Rik; C21; C230089I12Rik; DC42; Ira1; TBLR1; Tbl1xr1", "protein_names_uniprotkb": "F-box-like/WD repeat-containing protein TBL1XR1; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; Transducin beta-like 1X-related protein 1", "protein_names_refseq": "F-box-like/WD repeat protein TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1; TBL1-related protein 1; nuclear receptor corepressor/HDAC3 complex subunit TBLR1; transducin (beta)-like 1X-linked receptor 1; transducin beta-like 1X-related protein 1", "tax_id": 10090, "disease": "sensory system disease (Disease Ontology:DOID:0050155); autosomal dominant intellectual developmental disorder 41 (Disease Ontology:DOID:0070071); Pierpont syndrome (Disease Ontology:DOID:0081362)", "pathway": " (mmu:81004); (R-MMU-350054); (R-MMU-400206); (R-MMU-9029569); (R-MMU-9707564); (R-MMU-9841922)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "11063877;14980219;21750661;22645316;23806337;28348241;29187734;34428180;35820727;37458724;38885822", "class_list": "", "function": "Analysis of genes differentially expressed in the cortex of mice with the Tbl1xr1[Y446C/Y446C] variant., [RefSeq, PubMed]; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; TBLR1 and TBL1 have roles in specific nuclear receptor-mediated gene activation events, [RefSeq, PubMed]; The role of transducin beta-like 1 X-linked receptor 1 (TBL1XR1) in thyroid hormone metabolism and action in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UWL6;Q8CBG4;Q8VEG3;Q9EQD4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003714 transcription corepressor activity;GO:0000976 transcription cis-regulatory region binding;GO:0008013 beta-catenin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0000118 histone deacetylase complex;GO:0072686 mitotic spindle", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050872 white fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BHJ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80TE7-1", "uniprot_id": "LRRC7_MOUSE", "mass": 166901.0, "length": 1490, "protein_name": "Leucine-rich repeat-containing protein 7", "gene_name": "Lrrc7", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 7 isoform 2", "refseq_ac": "NP_001278381", "gene_names_uniprotkb": "Lrrc7; Kiaa1365; Lap1", "gene_names_refseq": "B230334C09Rik; Lrrc7; densin; mKIAA1365", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 7; Densin-180; Densin; Protein LAP1", "protein_names_refseq": "densin 180; leucine-rich repeat-containing protein 7 isoform 2; leucine-rich repeat-containing protein 7", "tax_id": 10090, "disease": "cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:242274); (R-MMU-438066); (R-MMU-5673001); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;16452087;17039495;17114649;21183079;21750661;22072671;22645316;24129315;28363979;31582721;32848054;33300544;34678516;39256359;40885482", "class_list": "", "function": "Adapter protein that is required for correct postsynapse architecture and regulates postsynaptic plasticity through interactions with different partners (By similarity). Through its interaction with CACNA1C, it enhances trafficking of voltage-dependent L-type calcium channels to the dendritic cell membrane and increases channel postsynaptic clustering, thereby facilitating excitatory calcium signaling (PubMed:28363979). It also serves as a scaffold that brings CAMK2A and PPP1CA into close proximity, probably facilitating rapid dephosphorylation of CAMK2A by PPP1CA and influencing CAMK2A-mediated regulation of postsynaptic plasticity (By similarity). Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term synaptic depression (PubMed:22072671)., [UniProtKB, UniProtKB, PubMed, PubMed]; Densin is a novel testicular protein expressed in the cell membranes of Sertoli cells., [RefSeq, PubMed]; Important role of LRRC7 in mGluR5 signaling; mutant mice had inappropriate juvenile aggressive behavior and significant anxiety-like behavior and social dysfunction in adulthood Publication Status: Online-Only, [RefSeq, PubMed]; Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005912 adherens junction;GO:0014069 postsynaptic density;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0010976 positive regulation of neuron projection development;GO:0098609 cell-cell adhesion;GO:0043113 receptor clustering;GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q80TE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54310-1", "uniprot_id": "LIPS_MOUSE", "mass": 83348.0, "length": 759, "protein_name": "Hormone-sensitive lipase", "gene_name": "Lipe", "organism": "Mouse", "refseq_name": "hormone-sensitive lipase isoform 2", "refseq_ac": "NP_001034596", "gene_names_uniprotkb": "Lipe", "gene_names_refseq": "4933403G17Rik; HSL; Lipe; REH", "protein_names_uniprotkb": "Hormone-sensitive lipase; 3.1.1.23; 3.1.1.79; HSL; Monoacylglycerol lipase LIPE; REH; Retinyl ester hydrolase", "protein_names_refseq": "hormone-sensitive lipase isoform 2; hormone-sensitive lipase; lipase, hormone sensitive; monoacylglycerol lipase LIPE; retinyl ester hydrolase", "tax_id": 10090, "disease": "familial partial lipodystrophy type 6 (Disease Ontology:DOID:0070206); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); arteriosclerosis (Disease Ontology:DOID:2349); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16890)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;11581251;15550674;15878856;17242355;19717842;19921680;20625037;21183079;21454566;21750661;23066022;23291629;31219806;31558710;33725478;34428180;36210013;38971480;7698747;9060404", "class_list": "", "function": "Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (PubMed:15550674, PubMed:20625037, PubMed:21454566, PubMed:23066022, PubMed:23291629). Shows a preferential hydrolysis of DAGs over TAGs and MAGs and of the fatty acid (FA) esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Preferentially hydrolyzes FA esters at the sn-3 position of the glycerol backbone in DAGs (PubMed:23066022). Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (PubMed:20625037, PubMed:21454566). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Reducing the lipase LIPE in mutant alpha-synuclein mice improves Parkinson-like deficits and reveals sex differences in fatty acid metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97866;Q3TE34;Q6GU16;Q8CDI9", "ec_number_list": "3.5.1.99;3.1.1.-;3.1.1.23;1.14.11.68;3.1.1.32;3.1.1.34;3.1.1.3;3.1.1.26;3.1.1.5;3.1.1.79;3.1.1.4;3.1.1.13;3.1.1.1;3.1.1.6;2.1.1.364;3.1.1.111;3.1.1.88;3.1.1.71;3.1.1.67;3.1.1.116;3.1.1.28;2.3.1.51;3.1.-.-;3.3.2.9;2.3.1.20;2.3.1.76", "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0016298 lipase activity;GO:0016788 hydrolase activity, acting on ester bonds;GO:0019901 protein kinase binding;GO:0047372 monoacylglycerol lipase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005811 lipid droplet", "go_biological_process": "GO:0070417 cellular response to cold;GO:0008203 cholesterol metabolic process;GO:0016042 lipid catabolic process;GO:0042758 long-chain fatty acid catabolic process;GO:0046340 diacylglycerol catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P54310-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55126-1", "uniprot_id": "NIPS2_MOUSE", "mass": 32933.0, "length": 281, "protein_name": "Protein NipSnap homolog 2", "gene_name": "Nipsnap2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nipsnap2; Gbas", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein NipSnap homolog 2; Glioblastoma-amplified sequence; NipSnap2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-9013407)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;22627147;30982665;33300544;34428180;36288343;37507081;39927985;9661659", "class_list": "", "function": "Protein involved in mitophagy by facilitating recruitment of the autophagy machinery required for clearance of damaged mitochondria (PubMed:30982665). Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy, such as autophagy receptors (CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY) and ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2) (By similarity). May act as a positive regulator of L-type calcium channels (PubMed:22627147)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0000423 mitophagy;GO:1901843 positive regulation of high voltage-gated calcium channel activity", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O55126-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZ04-1", "uniprot_id": "CSN7A_MOUSE", "mass": 30224.0, "length": 275, "protein_name": "COP9 signalosome complex subunit 7a", "gene_name": "Cops7a", "organism": "Mouse", "refseq_name": "COP9 signalosome complex subunit 7a isoform 2", "refseq_ac": "NP_001157561", "gene_names_uniprotkb": "Cops7a; Csn7a", "gene_names_refseq": "Cops7a; D6Ertd35e; SGN7a", "protein_names_uniprotkb": "COP9 signalosome complex subunit 7a; JAB1-containing signalosome subunit 7a; SGN7a; Signalosome subunit 7a", "protein_names_refseq": "COP9 (constitutive photomorphogenic) homolog, subunit 7a; COP9 (constitutive photomorphogenic), subunit 7a; COP9 complex S7a; COP9 signalosome complex subunit 7a isoform 2; COP9 signalosome complex subunit 7a; JAB1-containing signalosome subunit 7a; signalosome subunit 7a", "tax_id": 10090, "disease": "", "pathway": " (mmu:26894); (R-MMU-5696394); (R-MMU-6781823); (R-MMU-8856825); (R-MMU-8951664)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "11819679;15451666;21750661;34428180;37507081;9707402", "class_list": "", "function": "Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88546;Q925R8;Q9CPQ4;Q9CWD2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0010387 COP9 signalosome assembly;GO:0000338 protein deneddylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CZ04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UMR5-1", "uniprot_id": "MCU_MOUSE", "mass": 39682.0, "length": 350, "protein_name": "Calcium uniporter protein, mitochondrial", "gene_name": "Mcu", "organism": "Mouse", "refseq_name": "calcium uniporter protein, mitochondrial precursor", "refseq_ac": "NP_001028431", "gene_names_uniprotkb": "Mcu; Ccdc109a", "gene_names_refseq": "2010012O16Rik; C10orf42; Ccdc109a; D130073L02Rik; Gm64; Mcu", "protein_names_uniprotkb": "Calcium uniporter protein, mitochondrial", "protein_names_refseq": "calcium uniporter protein, mitochondrial precursor; calcium uniporter protein, mitochondrial; coiled-coil domain containing 109A", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700)", "pathway": " (mmu:215999); (R-MMU-8949215); (R-MMU-8949664)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "21685886;21685888;21750661;22829870;23409044;23576753;23774321;23900286;24212091;25251370;25603276;25732818;26057074;26119731;26119742;26644474;30084848;30779550;31219806;34428180;37828378", "class_list": "", "function": "Channel-forming and calcium-conducting subunit of the mitochondrial inner membrane calcium uniporter complex (uniplex), which mediates calcium uptake into the mitochondrial matrix (PubMed:21685886, PubMed:23900286, PubMed:24212091). MCU channel activity is regulated by the calcium-sensor subunits of the uniplex MICU1 and MICU2 (or MICU3) (By similarity). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways (By similarity). Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (By similarity). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:25603276, PubMed:26119731, PubMed:26119742). Participates in mitochondrial permeability transition during ischemia-reperfusion injury (PubMed:26119731). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (PubMed:25732818). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (PubMed:26644474). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (By similarity). Involved in antigen processing and presentation (PubMed:25251370)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Data demonstrate that the 40-kDa protein identified is the channel responsible for ruthenium-red-sensitive mitochondrial Ca(2+) uptake, thus providing a molecular basis for this process of utmost physiological and pathological relevance GeneRIF: Includes expression analysis of the mouse Ccdc109a (MCU) gene. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that the recently-identified mitochondrial Ca(2+) uniporter, MCU, is required for depolarisation-induced mitochondrial Ca(2+) increases, and for a sustained increase in cytosolic ATP/ADP ratio., [RefSeq, PubMed]; Exogenously expressed Mcu is mitochondrially localized and increases mitochondrial Ca(2+) levels following NMDA receptor activation, leading to increased mitochondrial membrane depolarization and excitotoxic cell death., [RefSeq, PubMed]; Genomic, physiological, biochemical and pharmacological data firmly establish MCU as an essential component of the mitochondrial Ca(2+) uniporter GeneRIF: In vivo silencing of CCDC109a (MCU) in mouse liver abolishes mitochondrial calcium uptake without perturbing gross liver anatomy, mitochondrial oxygen consumption or membrane potential. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RTD1;Q3TTK3", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0015292 uniporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0034704 calcium channel complex;GO:1990246 uniplex complex", "go_biological_process": "GO:0006091 generation of precursor metabolites and energy;GO:0008283 cell population proliferation;GO:0016477 cell migration;GO:0019722 calcium-mediated signaling;GO:0032024 positive regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q3UMR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0B2-1", "uniprot_id": "LMBD1_MOUSE", "mass": 61062.0, "length": 537, "protein_name": "Lysosomal cobalamin transport escort protein LMBD1", "gene_name": "Lmbrd1", "organism": "Mouse", "refseq_name": "lysosomal cobalamin transport escort protein LMBD1 isoform 2", "refseq_ac": "NP_001297412", "gene_names_uniprotkb": "Lmbrd1", "gene_names_refseq": "0910001K20Rik; LMBD1; Lmbrd1", "protein_names_uniprotkb": "Lysosomal cobalamin transport escort protein LMBD1; LMBD1; LMBR1 domain-containing protein 1; Protein N90b", "protein_names_refseq": "LMBR1 domain-containing protein 1; lysosomal cobalamin transport escort protein LMBD1 isoform 2; lysosomal cobalamin transport escort protein LMBD1; probable lysosomal cobalamin transporter; protein N90b", "tax_id": 10090, "disease": "methylmalonic aciduria and homocystinuria type cblF (Disease Ontology:DOID:0050717)", "pathway": " (mmu:68421); (R-MMU-9758881); (R-MMU-9758890)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;19144319;21183079;21750661;24078630;27061115;29187734", "class_list": "", "function": "LMBD1 plays an imperative role in mediating and regulating the endocytosis of the IR., [RefSeq, PubMed]; Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (PubMed:24078630). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (PubMed:24078630). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (PubMed:27061115)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3U696;Q8CCL7;Q8R3D6;Q8VH50;Q9CW67", "ec_number_list": "", "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0035612 AP-2 adaptor complex binding;GO:0031419 cobalamin binding;GO:0032050 clathrin heavy chain binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0072583 clathrin-dependent endocytosis;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0007369 gastrulation;GO:0038016 insulin receptor internalization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8K0B2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97798-1", "uniprot_id": "NEO1_MOUSE", "mass": 162920.0, "length": 1492, "protein_name": "Neogenin", "gene_name": "Neo1", "organism": "Mouse", "refseq_name": "neogenin isoform 1 precursor", "refseq_ac": "NP_032710", "gene_names_uniprotkb": "Neo1; Ngn", "gene_names_refseq": "2610028H22Rik; D930014N22Rik; Igdcc2; Neo1", "protein_names_uniprotkb": "Neogenin", "protein_names_refseq": "neogenin isoform 1 precursor", "tax_id": 10090, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:18007)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;17237772;17389603;19349973;19656770;21183079;21750661;23744777;30084848;30899004;32848054;33300544;35822049;40885482;9264410", "class_list": "", "function": "Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 1, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045296 cadherin binding;GO:0070700 BMP receptor binding;GO:0039706 co-receptor binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0097708 intracellular vesicle;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0048679 regulation of axon regeneration;GO:0001764 neuron migration;GO:0006355 regulation of DNA-templated transcription;GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P97798-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BX65-1", "uniprot_id": "MDFIC_MOUSE", "mass": 26094.0, "length": 247, "protein_name": "MyoD family inhibitor domain-containing protein", "gene_name": "Mdfic", "organism": "Mouse", "refseq_name": "myoD family inhibitor domain-containing protein", "refseq_ac": "NP_780297", "gene_names_uniprotkb": "Mdfic; Kdt1", "gene_names_refseq": "Kdt1; Mdfic; Mdfid", "protein_names_uniprotkb": "MyoD family inhibitor domain-containing protein; I-mfa domain-containing protein; Kidney cell line-derived transcript 1", "protein_names_refseq": "I-mfa domain-containing protein; kidney cell line-derived transcript 1; myoD family inhibitor domain-containing protein", "tax_id": 10090, "disease": "hereditary lymphedema (Disease Ontology:DOID:0050580); central conducting lymphatic anomaly (Disease Ontology:DOID:0081030)", "pathway": " (mmu:16543)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15207726;15465018;17891141;21750661;35235341;37590348", "class_list": "", "function": "MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels., [RefSeq, PubMed]; Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema., [RefSeq, PubMed]; Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation (PubMed:15207726, PubMed:15465018). Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta-catenin (By similarity). Affects axin-regulation of the WNT and JNK signaling pathways (By similarity). Involved in the development of lymphatic vessel valves (PubMed:35235341). Required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix (By similarity). Regulates the activity of mechanosensitive Piezo channel (PubMed:37590348)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, which in human have been shown to have different subcellular localization. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9H3;Q6NXM1;Q8BJS3", "ec_number_list": "", "go_molecular_function": "GO:0030957 Tat protein binding;GO:0030332 cyclin binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0030111 regulation of Wnt signaling pathway;GO:0042308 negative regulation of protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BX65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88491-1", "uniprot_id": "NSD1_MOUSE", "mass": 284084.0, "length": 2588, "protein_name": "Histone-lysine N-methyltransferase, H3 lysine-36 specific", "gene_name": "Nsd1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nsd1", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase, H3 lysine-36 specific; 2.1.1.357; H3-K36-HMTase; NR-binding SET domain-containing protein; Nuclear receptor-binding SET domain-containing protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "Sotos syndrome 1 (Disease Ontology:DOID:0112103); microcephaly (Disease Ontology:DOID:10907); Sotos syndrome (Disease Ontology:DOID:14748); syndrome (Disease Ontology:DOID:225); neuroblastoma (Disease Ontology:DOID:769); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (R-MMU-3214841)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12805229;15169884;20173027;21183079;21750661;25428506;30084848;34428180;36852467;9628876", "class_list": "", "function": "Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of negatively influencing transcription. May also positively influence transcription. Essential for early post-implantation development., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C480;Q9CT70", "ec_number_list": "2.1.1.357;2.1.1.-;2.1.1.354;2.1.1.359;2.1.1.367", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0042054 histone methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0000785 chromatin;GO:0035097 histone methyltransferase complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0033135 regulation of peptidyl-serine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O88491-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2C9-1", "uniprot_id": "MTMR7_MOUSE", "mass": 75608.0, "length": 660, "protein_name": "Phosphatidylinositol-3-phosphate phosphatase MTMR7", "gene_name": "Mtmr7", "organism": "Mouse", "refseq_name": "phosphatidylinositol-3-phosphate phosphatase MTMR7 isoform 1", "refseq_ac": "NP_001035789", "gene_names_uniprotkb": "Mtmr7", "gene_names_refseq": "Mtmr7", "protein_names_uniprotkb": "Phosphatidylinositol-3-phosphate phosphatase MTMR7; 3.1.3.64; Inositol 1,3-bisphosphate phosphatase; Myotubularin-related protein 7", "protein_names_refseq": "inositol 1,3-bisphosphate phosphatase; phosphatidylinositol-3-phosphate phosphatase MTMR7 isoform 1; phosphatidylinositol-3-phosphate phosphatase MTMR7; phosphatidylinositol-3-phosphate phosphatase", "tax_id": 10090, "disease": "centronuclear myopathy X-linked (Disease Ontology:DOID:0111225); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); centronuclear myopathy (Disease Ontology:DOID:14717)", "pathway": " (mmu:54384); (R-MMU-1660517)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12890864;21183079;21750661;22872234;23188820;34203471;38342025;38462034;9736772", "class_list": "", "function": "Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate (PtdIns(3)P) and inositol 1,3-bisphosphate (Ins(1,3)P2)., [UniProtKB, PubMed]; MTMR7 forms a complex with MTMR9 and dephosphorylates phosphatidylinositol 3-phosphate and Ins(1,3)P2 in neuronal cells., [RefSeq, PubMed]; MTMR7 suppresses the phenotypic switching of vascular smooth muscle cell and vascular intimal hyperplasia after injury via regulating p62/mTORC1-mediated glucose metabolism., [RefSeq, PubMed]; Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C4J6", "ec_number_list": "3.1.3.-;3.1.3.95;3.1.3.36;3.1.3.64", "go_molecular_function": "GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0016312 inositol bisphosphate phosphatase activity;GO:0052866 phosphatidylinositol phosphate phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0046856 phosphatidylinositol dephosphorylation;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9Z2C9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QX47-1", "uniprot_id": "SON_MOUSE", "mass": 265651.0, "length": 2444, "protein_name": "Protein SON", "gene_name": "Son", "organism": "Mouse", "refseq_name": "protein SON isoform 1", "refseq_ac": "NP_849211", "gene_names_uniprotkb": "Son; Nrebp", "gene_names_refseq": "2900011L12Rik; Son; mKIAA1019; nrebp", "protein_names_uniprotkb": "Protein SON; NRE-binding protein; Negative regulatory element-binding protein", "protein_names_refseq": "NRE-binding protein; Son cell proliferation protein; negative regulatory element-binding protein; protein SON isoform 1; protein SON", "tax_id": 10090, "disease": "ZTTK syndrome (Disease Ontology:DOID:0060953); congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay (Disease Ontology:DOID:0112359); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:20658)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "10.1101/2023.09.13.557529;10950926;17242355;19144319;20876580;21183079;21750661;22517741;22645316;22826440;22872234;23806337;24129315;25428506;29187734;30059200;31219806;32448361;32848054;34428180;34678516;35822049;36064721;36210013;36852467;38065069;38290089;40021952;40885482;40997131", "class_list": "", "function": "A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals indispensable SON functions in organ development and hematopoiesis. Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown of Son, a mouse homologue of the ZTTK syndrome gene, causes neuronal migration defects and dendritic spine abnormalities. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3' (By similarity). Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (By similarity). May also regulate the ghrelin signaling in hypothalamic neuron by acting as a negative regulator of GHSR expression (PubMed:20876580)., [UniProtKB, UniProtKB, PubMed]; SON is an essential m[6]A target for hematopoietic stem cell fate., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 33, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "E3WC91;E9PXW2;E9Q3H8;E9Q3I0;E9Q6M4;E9Q7G2;E9QAR8;E9QMT0;Q811G3;Q9CQ12;Q9CQK6;Q9QXP5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0050733 RS domain binding", "go_cellular_component": "GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0043066 negative regulation of apoptotic process;GO:0008380 RNA splicing;GO:0000281 mitotic cytokinesis", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "Q9QX47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7W5-1", "uniprot_id": "MED8_MOUSE", "mass": 29199.0, "length": 268, "protein_name": "Mediator of RNA polymerase II transcription subunit 8", "gene_name": "Med8", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 8 isoform 3", "refseq_ac": "NP_001277617", "gene_names_uniprotkb": "Med8; MED8; MNCb-2386", "gene_names_refseq": "2210021A15Rik; ARC32; Med8", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 8; ARC32; Activator-recruited cofactor 32 kDa component; Mediator complex subunit 8", "protein_names_refseq": "activator-recruited cofactor 32 kDa component; mediator of RNA polymerase II transcription subunit 8 isoform 3; mediator of RNA polymerase II transcription, subunit 8 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:80509)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25605945;31599954", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGB4;Q99LM4;Q9JJ84", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000151 ubiquitin ligase complex;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D7W5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U3R4-1", "uniprot_id": "LMF1_MOUSE", "mass": 65878.0, "length": 574, "protein_name": "Lipase maturation factor 1", "gene_name": "Lmf1", "organism": "Mouse", "refseq_name": "lipase maturation factor 1", "refseq_ac": "NP_083900", "gene_names_uniprotkb": "Lmf1; Tmem112", "gene_names_refseq": "2400010G15Rik; Lmf1; Tmem112; cld", "protein_names_uniprotkb": "Lipase maturation factor 1; Transmembrane protein 112", "protein_names_refseq": "lipase maturation factor 1; transmembrane protein 112", "tax_id": 10090, "disease": "familial lipase maturation factor 1 deficiency (Disease Ontology:DOID:0111422)", "pathway": " (mmu:76483); (R-MMU-8963889)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17994020;19471043;19783858;21750661;22345169;25035425;25066055;25428506;34428180;40997131", "class_list": "", "function": "Determined the alpha-synuclein-binding domain of beta-III tubulin and demonstrated that a short fragment containing this domain can suppress alpha-synuclein accumulation in the primary cultured cells, [RefSeq, PubMed]; Involved in the maturation of specific proteins in the endoplasmic reticulum., [UniProtKB, UniProtKB, UniProtKB]; Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL., [UniProtKB, PubMed, UniProtKB]; Results show that cotransfection of LPL with wild-type Lmf1 restores its ability to support normal lipase maturation., [RefSeq, PubMed]; Variation in Lmf1 expression is a posttranslational determinant of LPL activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDV1;Q8BM33;Q8BY75;Q8VDX3;Q9CWX8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0051006 positive regulation of lipoprotein lipase activity;GO:0090181 regulation of cholesterol metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3U3R4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97368-1", "uniprot_id": "MEIS3_MOUSE", "mass": 41726.0, "length": 378, "protein_name": "Homeobox protein Meis3", "gene_name": "Meis3", "organism": "Mouse", "refseq_name": "homeobox protein Meis3 isoform b", "refseq_ac": "NP_001264917", "gene_names_uniprotkb": "Meis3; Mrg2", "gene_names_refseq": "Meis3; Mrg2", "protein_names_uniprotkb": "Homeobox protein Meis3; Meis1-related protein 2", "protein_names_refseq": "homeobox protein Meis3 isoform b; homeobox protein Meis3; meis1-related protein 2; myeloid ecotropic viral integration site-related gene 2", "tax_id": 10090, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); leukemia (Disease Ontology:DOID:1240)", "pathway": " (mmu:17537)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12397630;18223676;21059917;21750661;22987645;8950991", "class_list": "", "function": "Data have demonstrated the presence of Meis, Pbx, and Prep proteins during early lineage segregation in mammals: Meis1, Meis3, Pbx1, Pbx2, Pbx3, and Prep1 in the mouse., [RefSeq, PubMed]; Meis3 is abundantly expressed in pancreatic islets and beta-cells and regulates beta-cell survival through 3-phosphoinositide-dependent protein kinase 1 (PDK1)., [RefSeq, PubMed]; Novel collaboration between Icsbp deficiency and Meis1/Meis3 in the acceleration of chronic myeloid leukemia-like disease., [RefSeq, PubMed]; The mRNA level of this protein was elevated in limb buds after treatment with ectopic acid., [RefSeq, PubMed]; The protein encoding this gene belongs to the three amino acid loop extension family of homeodomain transcription factors, which play essential roles in many embryonic processes. These proteins are characterized by an atypical homeodomain containing a three amino acid loop extension between helices 1 and 2. Expression of this gene begins during the compaction stage of embryogenesis and continues into the blastocyst stage. This gene is also expressed in pancreatic islet cells and beta-cells and regulates beta-cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]., [RefSeq]; Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q149R5;Q99L81", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P97368-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27782-1", "uniprot_id": "LEF1_MOUSE", "mass": 44059.0, "length": 397, "protein_name": "Lymphoid enhancer-binding factor 1", "gene_name": "Lef1", "organism": "Mouse", "refseq_name": "lymphoid enhancer-binding factor 1 isoform a", "refseq_ac": "NP_034833", "gene_names_uniprotkb": "Lef1", "gene_names_refseq": "3000002B05; Lef-1; Lef1", "protein_names_uniprotkb": "Lymphoid enhancer-binding factor 1; LEF-1", "protein_names_refseq": "lymphoid enhancer-binding factor 1 isoform a", "tax_id": 10090, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); prostate cancer (Disease Ontology:DOID:10283); anxiety disorder (Disease Ontology:DOID:2030); ovarian cancer (Disease Ontology:DOID:2394); papillary thyroid carcinoma (Disease Ontology:DOID:3969); prostate carcinoma in situ (Disease Ontology:DOID:8634); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16842); (R-MMU-201722); (R-MMU-3769402); (R-MMU-4086398); (R-MMU-4641265); (R-MMU-8951430); (R-MMU-9825892)", "pathway_count": 7, "publication_count": 17, "publication_id_list": "10498690;10966653;11445543;11731474;12446687;17218525;1827423;19304756;21750661;23562159;25605945;27713059;29148101;34428180;7651541;8415007;8898217", "class_list": "", "function": "Transcription factor that binds DNA in a sequence-specific manner (By similarity). Participates in the Wnt signaling pathway (PubMed:11445543). Activates transcription of target genes in the presence of CTNNB1 and EP300 (PubMed:12446687). PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (PubMed:11731474). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (By similarity). Regulates T-cell receptor alpha enhancer function (By similarity). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (PubMed:23562159). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (PubMed:29148101). May play a role in hair cell differentiation and follicle morphogenesis (PubMed:11445543)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Transcription factor that binds DNA in a sequence-specific manner. Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling. May play a role in hair cell differentiation and follicle morphogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0030854 positive regulation of granulocyte differentiation;GO:0045063 T-helper 1 cell differentiation;GO:0048341 paraxial mesoderm formation;GO:0021861 forebrain radial glial cell differentiation;GO:1901331 positive regulation of odontoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P27782-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63005-1", "uniprot_id": "LIS1_MOUSE", "mass": 46670.0, "length": 410, "protein_name": "Platelet-activating factor acetylhydrolase IB subunit beta", "gene_name": "Pafah1b1", "organism": "Mouse", "refseq_name": "platelet-activating factor acetylhydrolase IB subunit beta", "refseq_ac": "NP_038653", "gene_names_uniprotkb": "Pafah1b1; Lis-1; Lis1; Pafaha", "gene_names_refseq": "LIS-1; Lis1; MMS10-U; Mdsh; Ms10u; Pafah1b1; Pafaha", "protein_names_uniprotkb": "Platelet-activating factor acetylhydrolase IB subunit beta; LIS-1; Lissencephaly-1 protein; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha", "protein_names_refseq": "PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha; Pafaha/Lis1; lissencephaly-1 protein; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1; platelet-activating factor acetylhydrolase 45kD subunit; platelet-activating factor acetylhydrolase IB subunit alpha; platelet-activating factor acetylhydrolase IB subunit beta", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Miller-Dieker lissencephaly syndrome (Disease Ontology:DOID:0060469); lissencephaly 1 (Disease Ontology:DOID:0112237); status epilepticus (Disease Ontology:DOID:1824); schizophrenia (Disease Ontology:DOID:5419); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:18472); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-5663220); (R-MMU-6811436); (R-MMU-68877); (R-MMU-8854518); (R-MMU-9648025)", "pathway_count": 16, "publication_count": 48, "publication_id_list": "11001923;11056530;11163258;11163259;11163260;11231056;11344260;11756344;11940666;12551946;12796778;12885786;12911752;12950100;14507966;14578885;14691133;15147871;15173193;15274919;15473966;15473967;15572112;15939891;16107726;16203747;16258276;16291865;16369480;16481446;17330141;19224205;20173027;21750661;23097494;25428506;30779550;34428180;35820727;36519536;37280197;37507081;37828378;39927985;40684658;7751941;7821822;9479492", "class_list": "", "function": "A selective LIS1 requirement for mitotic spindle assembly discriminates distinct T-cell division mechanisms within the T-cell lineage. Publication Status: Online-Only, [RefSeq, PubMed]; LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways. Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (By similarity). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (PubMed:17330141)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, HAMAP, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35592;P43035;P81692;Q9R2A6", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0051219 phosphoprotein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000235 astral microtubule;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:0001961 positive regulation of cytokine-mediated signaling pathway;GO:0007611 learning or memory;GO:0008344 adult locomotory behavior;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 5.1, "record_id": "P63005-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BJZ3-1", "uniprot_id": "LFG3_MOUSE", "mass": 34393.0, "length": 309, "protein_name": "Protein lifeguard 3", "gene_name": "Tmbim1", "organism": "Mouse", "refseq_name": "protein lifeguard 3", "refseq_ac": "NP_081430", "gene_names_uniprotkb": "Tmbim1; Lfg3; Recs1", "gene_names_refseq": "2310061B02Rik; RECS1; Tmbib1; Tmbim1; mKIAA4161", "protein_names_uniprotkb": "Protein lifeguard 3; Protein RECS1; Responsive to centrifugal force and shear stress gene 1 protein; Transmembrane BAX inhibitor motif-containing protein 1", "protein_names_refseq": "protein lifeguard 3; responsive to centrifugal force and shear stress gene 1 protein; transmembrane BAX inhibitor motif-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69660); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "16607040;16636500;19144319;19784873;21750661;26495903;28481357;30084848;30217448;34107313", "class_list": "", "function": "An endosomal/lysosomal membrane protein which plays protective roles in vascular remodeling, [RefSeq, PubMed]; Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling., [UniProtKB, PubMed, PubMed]; RECS1 negatively regulates aortic MMP-9 production and knocking out RECS1 induces susceptibility to aortic dilation as well as cystic medial degeneration in the aged mice., [RefSeq, PubMed]; TMBIM1 is an effective suppressor of steatohepatitis and a previously unknown regulator of the multivesicular body (MVB)-lysosomal pathway. Tmbim1 expression in hepatocytes substantially inhibited high-fat diet-induced insulin resistance, hepatic steatosis and inflammation in mice. Overexpression of Tmbim1 in the liver effectively inhibited a severe form of NAFLD in mice., [RefSeq, PubMed]; TMBIM1 is an inhibitor of adipogenesis and its depletion promotes adipocyte hyperplasia and improves obesity-related metabolic disease., [RefSeq, PubMed]; Tmbim1 is a key suppressor of metabolic stress-induced cardiomyopathy.Tmbim1 was highly expressed in hearts of mice fed high fat diet., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CH91;Q99KB6", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005123 death receptor binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:2000504 positive regulation of blood vessel remodeling;GO:0043086 negative regulation of catalytic activity;GO:0043524 negative regulation of neuron apoptotic process;GO:1903077 negative regulation of protein localization to plasma membrane;GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BJZ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BN59-1", "uniprot_id": "LARP6_MOUSE", "mass": 54873.0, "length": 492, "protein_name": "La-related protein 6", "gene_name": "Larp6", "organism": "Mouse", "refseq_name": "la-related protein 6", "refseq_ac": "NP_080511", "gene_names_uniprotkb": "Larp6", "gene_names_refseq": "5430431G03Rik; Achn; Larp6", "protein_names_uniprotkb": "La-related protein 6; Acheron; Achn; La ribonucleoprotein domain family member 6", "protein_names_refseq": "La ribonucleoprotein domain family, member 6; acheron; la-related protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:67557)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16452087;17383118;19481601;21183079;21387291;25428506;28211947", "class_list": "", "function": "Achn enhances human breast tumor growth and vascularization and that this activity is dependent on nuclear localization., [RefSeq, PubMed]; Achn plays key roles in the processes of differentiation and self-renewal, [RefSeq, PubMed]; Data indicate that insulin-like growth factor 1 (IGF1) could promote collagen I alpha 2 (COL1A2) expression and osteoblast differentiation in primary pre-osteoblasts by increasing La ribonucleoprotein domain family member 6 (Larp6) expression via a posttranscriptional mechanism., [RefSeq, PubMed]; Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9 (By similarity)., [UniProtKB]; These data define Achn as a newly discovered regulatory molecule that presumably mediates a variety of developmental and homeostatic processes in animals., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C9A3;Q8CA51;Q9CTN3;Q9D3J0", "ec_number_list": "", "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003729 mRNA binding;GO:0017022 myosin binding;GO:0048027 mRNA 5'-UTR binding;GO:0035613 RNA stem-loop binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006396 RNA processing;GO:0006417 regulation of translation;GO:0032967 positive regulation of collagen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BN59-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61168-1", "uniprot_id": "LAPM5_MOUSE", "mass": 29602.0, "length": 261, "protein_name": "Lysosomal-associated transmembrane protein 5", "gene_name": "Laptm5", "organism": "Mouse", "refseq_name": "lysosomal-associated transmembrane protein 5", "refseq_ac": "NP_034816", "gene_names_uniprotkb": "Laptm5", "gene_names_refseq": "E3; Laptm5; Stra13", "protein_names_uniprotkb": "Lysosomal-associated transmembrane protein 5; Lysosomal-associated multitransmembrane protein 5; Retinoic acid-inducible E3 protein", "protein_names_refseq": "lysosomal-associated multitransmembrane protein 5; lysosomal-associated transmembrane protein 5; retinoic acid-inducible E3 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:16792)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11801660;12682304;16075062;17947660;20173027;21750661;25605945;26495903;28011936;30084848;31219806;32152506;34428180;35820727;36210013;37156795;37525083;37713124;8661146;8839844", "class_list": "", "function": "C-Myc inhibits LAPTM5 expression in B-cell lymphomas., [RefSeq, PubMed]; Intracerebral Hemorrhage-Induced Brain Injury: the Role of Lysosomal-Associated Transmembrane Protein 5., [RefSeq, PubMed]; Lysosomal-associated protein transmembrane 5 ameliorates non-alcoholic steatohepatitis by promoting the degradation of CDC42 in mice. Publication Status: Online-Only, [RefSeq, PubMed]; May have a special functional role during embryogenesis and in adult hematopoietic cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60923", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0031625 ubiquitin protein ligase binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:2000646 positive regulation of receptor catabolic process;GO:0032703 negative regulation of interleukin-2 production;GO:0097214 positive regulation of lysosomal membrane permeability;GO:0006886 intracellular protein transport;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q61168-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BUI3-1", "uniprot_id": "LRWD1_MOUSE", "mass": 71594.0, "length": 648, "protein_name": "Leucine-rich repeat and WD repeat-containing protein 1", "gene_name": "LRWD1; Lrwd1", "organism": "Mouse", "refseq_name": "leucine-rich repeat and WD repeat-containing protein 1", "refseq_ac": "NP_082167", "gene_names_uniprotkb": "LRWD1; Lrwd1; Orca", "gene_names_refseq": "1200011O22Rik; Lrwd1; Orca", "protein_names_uniprotkb": "Leucine-rich repeat and WD repeat-containing protein 1; ORC-associated protein; ORCA; Origin recognition complex-associated protein", "protein_names_refseq": "ORC-associated protein; leucine-rich repeat and WD repeat-containing protein 1; origin recognition complex-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:71735)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17074343;20180869;21750661;22427655;25605945;31219806;34203471;34428180;35451548", "class_list": "", "function": "Immunostaining and immunoprecipitation showed colocalization and interaction between lrwd1 and gamma-tubulin respectively, implicating lrwd1 as a candidate centrosomal protein. These results suggest that lrwd1 may play an important role in spermatogenesis., [RefSeq, PubMed]; Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing, [RefSeq, PubMed]; Lrwd1 impacts cell proliferation and the silencing of repetitive DNA elements., [RefSeq, PubMed]; Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation (By similarity). Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Z2P9;Q3TIG2;Q8BKI3;Q9DBW4", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008327 methyl-CpG binding;GO:0061628 histone H3K27me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0000776 kinetochore", "go_biological_process": "GO:0006260 DNA replication;GO:0006325 chromatin organization;GO:0071169 establishment of protein localization to chromatin", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BUI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UQS2-1", "uniprot_id": "LSME1_MOUSE", "mass": 14186.0, "length": 128, "protein_name": "Leucine-rich single-pass membrane protein 1", "gene_name": "Lsmem1", "organism": "Mouse", "refseq_name": "leucine-rich single-pass membrane protein 1", "refseq_ac": "NP_001028609", "gene_names_uniprotkb": "Lsmem1; Gm889", "gene_names_refseq": "Gm889; Lsmem1", "protein_names_uniprotkb": "Leucine-rich single-pass membrane protein 1", "protein_names_refseq": "leucine-rich single-pass membrane protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:380755)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZ75", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UQS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6A0A2-1", "uniprot_id": "LAR4B_MOUSE", "mass": 81627.0, "length": 741, "protein_name": "La-related protein 4B", "gene_name": "Larp4b", "organism": "Mouse", "refseq_name": "la-related protein 4B isoform 2", "refseq_ac": "NP_001298046", "gene_names_uniprotkb": "Larp4b; D13Wsu64e; Kiaa0217; Larp5", "gene_names_refseq": "A130023E24Rik; A630096F19; D13Wsu64e; Larp4b; Larp5", "protein_names_uniprotkb": "La-related protein 4B; La ribonucleoprotein domain family member 4B; La ribonucleoprotein domain family member 5; La-related protein 5", "protein_names_refseq": "La ribonucleoprotein domain family, member 4B; La ribonucleoprotein domain family, member 5; la ribonucleoprotein domain family member 5; la-related protein 4B isoform 2; la-related protein 4B; la-related protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:217980)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;19144319;21183079;21750661;22517741;22645316;24129315;28528544;29562282;30059200;32782141;32848054;34428180;35822049;36852467;40021952;40885482", "class_list": "", "function": "Stimulates mRNA translation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUH7;Q6AZA8;Q8BJP3;Q8BY17", "ec_number_list": "", "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0045727 positive regulation of translation;GO:1905870 positive regulation of 3'-UTR-mediated mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q6A0A2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BYM5-1", "uniprot_id": "NLGN3_MOUSE", "mass": 91162.0, "length": 825, "protein_name": "Neuroligin-3", "gene_name": "Nlgn3", "organism": "Mouse", "refseq_name": "neuroligin-3 precursor", "refseq_ac": "NP_766520", "gene_names_uniprotkb": "Nlgn3", "gene_names_refseq": "A230085M13Rik; HNL3; NL3; NLG3; Nlgn3", "protein_names_uniprotkb": "Neuroligin-3; Gliotactin homolog", "protein_names_refseq": "gliotactin homolog; neuroligin 3 protein; neuroligin-3 precursor", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); sciatic neuropathy (Disease Ontology:DOID:11446); autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (mmu:245537); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11329178;16982420;17897391;18034455;18434543;19243448;19926856;21750661;30100184;33300544;35820727;37865312", "class_list": "glycogene", "function": "Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 57, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2AGI1;Q8BXR4", "ec_number_list": "", "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0097110 scaffold protein binding;GO:0042043 neurexin family protein binding;GO:0038023 signaling receptor activity;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030054 cell junction", "go_biological_process": "GO:0060024 rhythmic synaptic transmission;GO:0097104 postsynaptic membrane assembly;GO:2000331 regulation of terminal button organization;GO:0007612 learning;GO:0008542 visual learning", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BYM5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q69ZK9-1", "uniprot_id": "NLGN2_MOUSE", "mass": 90989.0, "length": 836, "protein_name": "Neuroligin-2", "gene_name": "Nlgn2", "organism": "Mouse", "refseq_name": "neuroligin-2 precursor", "refseq_ac": "NP_942562", "gene_names_uniprotkb": "Nlgn2; Kiaa1366", "gene_names_refseq": "NL2; NLG2; Nlgn2", "protein_names_uniprotkb": "Neuroligin-2", "protein_names_refseq": "neuroligin-2 precursor; ortholog of human and rat neuroligin 2 NLGN2", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); sciatic neuropathy (Disease Ontology:DOID:11446); status epilepticus (Disease Ontology:DOID:1824); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:216856); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 33, "publication_id_list": "10892652;15540461;15620359;16982420;17114649;17897391;18250328;18434543;19553444;19755106;19859968;19889999;19926856;20530218;21183079;21750661;23358245;23751499;25297980;25428506;28279354;29742426;30084848;30100184;30779550;31219806;31599954;33300544;34428180;37828378;37865312;38570872;38657049", "class_list": "glycogene", "function": "Neuroligin-2 shapes individual slow waves during slow-wave sleep and the response to sleep deprivation in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Structural and functional reorganization of inhibitory synapses by activity-dependent cleavage of neuroligin-2., [RefSeq, PubMed]; The neuroligin 2 is as a new cell adhesion protein specific for inhibitory synapses and open new avenues for identifiying the constituents of this unique type of postsynaptic specialization., [RefSeq, PubMed]; Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (PubMed:29742426). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 38, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q5F288", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0050839 cell adhesion molecule binding;GO:0042043 neurexin family protein binding;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0072553 terminal button organization;GO:0099054 presynapse assembly;GO:0097116 gephyrin clustering involved in postsynaptic density assembly;GO:1901142 insulin metabolic process;GO:0097104 postsynaptic membrane assembly", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q69ZK9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59240-1", "uniprot_id": "NPHP4_MOUSE", "mass": 157269.0, "length": 1425, "protein_name": "Nephrocystin-4", "gene_name": "Nphp4", "organism": "Mouse", "refseq_name": "nephrocystin-4", "refseq_ac": "NP_700473", "gene_names_uniprotkb": "Nphp4", "gene_names_refseq": "4930564O18Rik; Nphp4; nmf192", "protein_names_uniprotkb": "Nephrocystin-4; Nephroretinin", "protein_names_refseq": "nephrocystin-4; nephroretinin", "tax_id": 10090, "disease": "Senior-Loken syndrome (Disease Ontology:DOID:0050576); Meckel syndrome (Disease Ontology:DOID:0050778); ciliopathy (Disease Ontology:DOID:0060340); Joubert syndrome 4 (Disease Ontology:DOID:0110999); nephronophthisis 4 (Disease Ontology:DOID:0111115); nephronophthisis (Disease Ontology:DOID:12712); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:260305); (R-MMU-2028269); (R-MMU-5620912)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "12205563;12244321;16452087;21565611;25428506;29899041;34203471;40021952", "class_list": "", "function": "Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (By similarity). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may down-regulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (By similarity). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Recessive mutations in the NPHP4 gene, encoding the protein nephroretinin, in humans cause nephronophthisis type 4 and Senior-Loken. There is evolutionary conservation of the NPHP4 gene, with an orhtolog in C. elegans., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B1AS30", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005911 cell-cell junction", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0030317 flagellated sperm motility;GO:0045494 photoreceptor cell maintenance;GO:0060041 retina development in camera-type eye;GO:0035845 photoreceptor cell outer segment organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P59240-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P3A8-1", "uniprot_id": "ODBB_MOUSE", "mass": 42880.0, "length": 390, "protein_name": "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial", "gene_name": "Bckdhb", "organism": "Mouse", "refseq_name": "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial isoform 1", "refseq_ac": "NP_001292864", "gene_names_uniprotkb": "Bckdhb", "gene_names_refseq": "BCKDE1B; BCKDH E1-beta; Bckdhb", "protein_names_uniprotkb": "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; 1.2.4.4; BCKDE1B; BCKDH E1-beta; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain", "protein_names_refseq": "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial isoform 1; 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; branched-chain alpha-keto acid dehydrogenase E1 component beta chain", "tax_id": 10090, "disease": "maple syrup urine disease type IB (Disease Ontology:DOID:0061206); maple syrup urine disease (Disease Ontology:DOID:9269)", "pathway": " (mmu:12040); (R-MMU-70895); (R-MMU-9859138)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "16875466;23576753;36880392;37453647;8268236", "class_list": "", "function": "Disruption of the BDK gene establishes that regulation of BCKDH by phosphorylation is critically important for the regulation of oxidative disposal of branched-chain amino acids., [RefSeq, PubMed]; Successful treatment of severe MSUD in Bckdhb[-/-] mice with neonatal AAV gene therapy., [RefSeq, PubMed]; This gene encodes the beta chain of the branched chain alpha ketoacid dehydrogenase (Bckdh) complex. The encoded protein exists in a heterotetrameric complex containing the Bckdh alpha subunit to form the E1 catalytic component of Bckdh complex. The Bckdh complex catalyzes the oxidative decarboxylation of branched chain ketoacids to their corresponding acyl-CoA esters, during the catabolism of leucine, isoleucine and valine. In humans, certain mutations in this gene cause maple syrup urine disease. Alternative splicing results in multiple transcript variants encoding different isoforms. A pseudogene for this gene has been identified. [provided by RefSeq, Apr 2015]., [RefSeq]; Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.1.4;2.7.11.-;2.7.11.1;2.7.11.4;1.2.4.4;2.3.1.168;3.1.3.16;3.1.3.52", "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0003863 branched-chain 2-oxo acid dehydrogenase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0007584 response to nutrient;GO:0009083 branched-chain amino acid catabolic process;GO:0009063 amino acid catabolic process;GO:0120552 branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6P3A8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01887-1", "uniprot_id": "RYK_MOUSE", "mass": 66285.0, "length": 594, "protein_name": "Inactive tyrosine-protein kinase RYK", "gene_name": "Ryk", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase RYK isoform 2 precursor", "refseq_ac": "NP_001036072", "gene_names_uniprotkb": "Ryk; Mrk", "gene_names_refseq": "ERK-3; Ryk; Vik", "protein_names_uniprotkb": "Inactive tyrosine-protein kinase RYK; Kinase VIK; Met-related kinase; NYK-R", "protein_names_refseq": "NYK-R; growth factor receptor; kinase VIK; met-related kinase; tyrosine-protein kinase RYK isoform 2 precursor; tyrosine-protein kinase RYK", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:20187); (R-MMU-201681)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11135307;1333503;1334548;15454084;16116452;16723543;19000841;21750661;25428506;35671428;7822791;8380921;8394755", "class_list": "", "function": "May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; WNT/RYK signaling functions as an antiinflammatory modulator in the lung mesenchyme., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q61890", "ec_number_list": "", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004888 transmembrane signaling receptor activity;GO:0005109 frizzled binding;GO:0005524 ATP binding;GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:1904935 positive regulation of cell proliferation in midbrain;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007409 axonogenesis;GO:0010976 positive regulation of neuron projection development;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q01887-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63943-1", "uniprot_id": "MEF2D_MOUSE", "mass": 55065.0, "length": 514, "protein_name": "Myocyte-specific enhancer factor 2D", "gene_name": "Mef2d", "organism": "Mouse", "refseq_name": "myocyte-specific enhancer factor 2D isoform 1", "refseq_ac": "NP_001297516", "gene_names_uniprotkb": "Mef2d", "gene_names_refseq": "Mef2d", "protein_names_uniprotkb": "Myocyte-specific enhancer factor 2D", "protein_names_refseq": "myocyte-specific enhancer factor 2D isoform 1; myocyte-specific enhancer factor 2D", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); intellectual disability (Disease Ontology:DOID:1059); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (mmu:17261); (R-MMU-525793)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;15834131;16166628;16407541;16424906;18299387;19131326;21183079;21750661;23523791;25733682;34428180;35481398;36293168;38791246;40885482;40997131;8114702;9013788", "class_list": "", "function": "MEF2D Functions as a Tumor Suppressor in Breast Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; PGC-1alpha and MEF2 Regulate the Transcription of the Carnitine Transporter OCTN2 Gene in C2C12 Cells and in Mouse Skeletal Muscle. Publication Status: Online-Only, [RefSeq, PubMed]; Sevoflurane activates MEF2D-mediated Wnt/beta-catenin signaling pathway via microRNA-374b-5p to affect renal ischemia/reperfusion injury., [RefSeq, PubMed]; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9QKS9;Q63944", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q63943-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UHF3-1", "uniprot_id": "MIER3_MOUSE", "mass": 61521.0, "length": 551, "protein_name": "Mesoderm induction early response protein 3", "gene_name": "Mier3", "organism": "Mouse", "refseq_name": "mesoderm induction early response protein 3", "refseq_ac": "NP_766181", "gene_names_uniprotkb": "Mier3", "gene_names_refseq": "5730509D14; D130064H19Rik; Mier3", "protein_names_uniprotkb": "Mesoderm induction early response protein 3; Mi-er3", "protein_names_refseq": "mesoderm induction early response 1, family member 3; mesoderm induction early response protein 3; mi-er3", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); invasive ductal carcinoma (Disease Ontology:DOID:3008); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:218613)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17242355;21183079;21750661", "class_list": "", "function": "Transcriptional repressor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SYJ7;Q3UGR9;Q8BND7;Q8BSS0", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UHF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51667-1", "uniprot_id": "MLRV_MOUSE", "mass": 18864.0, "length": 166, "protein_name": "Myosin regulatory light chain 2, ventricular/cardiac muscle isoform", "gene_name": "Myl2", "organism": "Mouse", "refseq_name": "myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform 1", "refseq_ac": "NP_034991", "gene_names_uniprotkb": "Myl2; Mylpc", "gene_names_refseq": "Gm32672; MLC-2s/v; MLC-2v; MLC-2; Mlc2v; Myl2; Mylpc", "protein_names_uniprotkb": "Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; MLC-2s/v; MLC-2v; MLC-2; Myosin light chain 2, slow skeletal/ventricular muscle isoform", "protein_names_refseq": "myosin light chain 2v; myosin light chain, phosphorylatable, cardiac ventricles; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform 1", "tax_id": 10090, "disease": "infantile-onset myofibrillar myopathy 12 with cardiomyopathy (Disease Ontology:DOID:0051044); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); hypertrophic cardiomyopathy 10 (Disease Ontology:DOID:0110316)", "pathway": " (mmu:17906); (R-MMU-390522)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10409661;1379240;16908724;20038585;20445002;20668449;21183079;21750661;22426213;23095280;31402636;36288343;37507081;8506363;9422794", "class_list": "", "function": "Contractile protein that plays a role in heart development and function (PubMed:10409661). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity) (PubMed:10409661, PubMed:16908724, PubMed:22426213). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (PubMed:9422794)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P8P4;Q9QVP3", "ec_number_list": "", "go_molecular_function": "GO:0003785 actin monomer binding;GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0030016 myofibril;GO:0031672 A band;GO:0097512 cardiac myofibril", "go_biological_process": "GO:0007507 heart development;GO:0060047 heart contraction;GO:0003007 heart morphogenesis;GO:0009791 post-embryonic development;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P51667-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70412-1", "uniprot_id": "CUZD1_MOUSE", "mass": 68195.0, "length": 607, "protein_name": "CUB and zona pellucida-like domain-containing protein 1", "gene_name": "Cuzd1", "organism": "Mouse", "refseq_name": "CUB and zona pellucida-like domain-containing protein 1 precursor", "refseq_ac": "NP_032437", "gene_names_uniprotkb": "Cuzd1; Itmap1", "gene_names_refseq": "Cuzd1; Erg-1; Itmap1; Uo-44; Usg; Utczp", "protein_names_uniprotkb": "CUB and zona pellucida-like domain-containing protein 1; CUB and ZP domain-containing protein 1; Integral membrane-associated protein 1", "protein_names_refseq": "CUB and ZP domain-containing protein 1; CUB and zona pellucida-like domain-containing protein 1 precursor; CUB and zona pellucida-like domain-containing protein 1; integral membrane-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:16433)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12401800;17393098;28278176;29321207;9480914", "class_list": "", "function": "Data show that CUZD1 interacts with a complex containing JAK1/JAK2 and STAT5, downstream transducers of prolactin signaling in the mammary gland. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that overexpression of Cuzd1, regulator of growth factor signaling pathways controlled by PRLR and STAT5, promotes tumorigenesis in mammary epithelial cells. (Cuzd1 = Cub and zona pellucida-like domain-containing protein-1; Prlr = prolactin receptor; Stat5 = signal transducer and activator of transcription-5), [RefSeq, PubMed]; ERG-1 mediates SiO(2)-driven transcription of Mmp14 in macrophages., [RefSeq, PubMed]; Localized to zymogen granules, where it functions in trypsinogen activation (PubMed:12401800). May indirectly regulate cell motility, cell-cell and cell/extracellular matrix interactions (By similarity)., [UniProtKB, UniProtKB, PubMed]; Plays an essential role in trypsinogen activation and both impaired and augmented trypsinogen activation can be associated with increased severity of pancreatitis, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B2RU69;Q9CTZ7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0042588 zymogen granule;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0016020 membrane;GO:0042589 zymogen granule membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0051301 cell division;GO:0007565 female pregnancy;GO:0009755 hormone-mediated signaling pathway;GO:0032023 trypsinogen activation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P70412-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P5D4-1", "uniprot_id": "CP135_MOUSE", "mass": 133345.0, "length": 1140, "protein_name": "Centrosomal protein of 135 kDa", "gene_name": "Cep135", "organism": "Mouse", "refseq_name": "centrosomal protein of 135 kDa", "refseq_ac": "NP_950197", "gene_names_uniprotkb": "Cep135; Cep4; Kiaa0635", "gene_names_refseq": "Cep135; Cep4; Gm1044", "protein_names_uniprotkb": "Centrosomal protein of 135 kDa; Centrosomal protein 4; Cep135", "protein_names_refseq": "centrosomal protein 4; centrosomal protein of 135 kDa", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 8 (Disease Ontology:DOID:0070282)", "pathway": " (mmu:381644); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "11781336;14983524;21183079;32069316;38062802", "class_list": "", "function": "Centrosomal Protein CEP135 Regulates the Migration and Angiogenesis of Endothelial Cells in a Microtubule-Dependent Manner., [RefSeq, PubMed]; Centrosomal microtubule-binding protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6A030", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005814 centriole", "go_biological_process": "GO:1904951 positive regulation of establishment of protein localization;GO:1902857 positive regulation of non-motile cilium assembly;GO:0010457 centriole-centriole cohesion;GO:0007099 centriole replication", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6P5D4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C6G1-1", "uniprot_id": "CF410_MOUSE", "mass": 28239.0, "length": 249, "protein_name": "Cilia- and flagella-associated protein 410", "gene_name": "Cfap410", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 410", "refseq_ac": "NP_080707", "gene_names_uniprotkb": "Cfap410", "gene_names_refseq": "1810043G02Rik; Cfap410; D10Jhu13e", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 410", "protein_names_refseq": "cilia- and flagella-associated protein 410; protein C21orf2 homolog", "tax_id": 10090, "disease": "axial spondylometaphyseal dysplasia (Disease Ontology:DOID:0112299)", "pathway": " (mmu:67884)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21289087;26167768;26294103;26974433;27548899;39227882", "class_list": "", "function": "ALS-associated C21ORF2 variant disrupts DNA damage repair, mitochondrial metabolism, neuronal excitability and NEK1 levels in human motor neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in cilia formation and/or maintenance (PubMed:21289087). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Involved in DNA damage repair (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91Z02", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0097733 photoreceptor cell cilium;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006974 DNA damage response;GO:0007010 cytoskeleton organization;GO:0060271 cilium assembly;GO:0008360 regulation of cell shape;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C6G1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0H6-1", "uniprot_id": "CST9_MOUSE", "mass": 16094.0, "length": 137, "protein_name": "Cystatin-9", "gene_name": "Cst9", "organism": "Mouse", "refseq_name": "cystatin-9 precursor", "refseq_ac": "NP_034109", "gene_names_uniprotkb": "Cst9; Cresp", "gene_names_refseq": "Cst9; M12; cresp; testatin", "protein_names_uniprotkb": "Cystatin-9; Testatin", "protein_names_refseq": "cystatin-9 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:13013)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15923608;23922243;9826679", "class_list": "", "function": "May be involved in testis development (PubMed:9826679). May play a role in hematopoietic differentiation or inflammation (By similarity). Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria (PubMed:23922243)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q545L7", "ec_number_list": "", "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019730 antimicrobial humoral response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z0H6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61496-1", "uniprot_id": "DDX4_MOUSE", "mass": 76470.0, "length": 702, "protein_name": "ATP-dependent RNA helicase DDX4", "gene_name": "Ddx4", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase DDX4 isoform 2", "refseq_ac": "NP_034159", "gene_names_uniprotkb": "Ddx4; Mvh; Vasa", "gene_names_refseq": "Ddx4; Mvh; VASA", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX4; 3.6.4.13; DEAD box protein 4; Mvh; Vasa homolog", "protein_names_refseq": "ATP-dependent RNA helicase DDX4 isoform 2; D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 4; DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 4; DEAD box polypeptide 4; DEAD box protein 4; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4; mvh / m'vasa; probable ATP-dependent RNA helicase DDX4; vasa homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:13206); (R-MMU-9696264)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;14648869;14736746;16787967;17141210;20439430;21183079;22900038;27622290;28254886;28633017;36001654;7991615", "class_list": "", "function": "ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:20439430, PubMed:28633017). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:20439430, PubMed:28633017). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (PubMed:20439430, PubMed:28633017). Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs (PubMed:28633017)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D5X7", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.4.17.22;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.5.2;3.6.1.15;3.1.4.-;2.7.11.39;2.7.10.1;2.7.3.2;5.6.2.-;7.2.2.-;7.6.2.16;3.1.3.48;2.1.1.386;3.1.26.-;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0030317 flagellated sperm motility;GO:0032880 regulation of protein localization;GO:0007281 germ cell development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q61496-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80Y44-1", "uniprot_id": "DDX10_MOUSE", "mass": 100739.0, "length": 875, "protein_name": "Probable ATP-dependent RNA helicase DDX10", "gene_name": "Ddx10", "organism": "Mouse", "refseq_name": "probable ATP-dependent RNA helicase DDX10", "refseq_ac": "NP_084212", "gene_names_uniprotkb": "Ddx10", "gene_names_refseq": "4632415A01Rik; Ddx10", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX10; 3.6.4.13; DEAD box protein 10", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 10; DEAD box protein 10; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase); probable ATP-dependent RNA helicase DDX10", "tax_id": 10090, "disease": "", "pathway": " (mmu:77591)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17242355;19131326;21183079;23806337;25428506;25605945;30084848;30779550;31219806;31599954;34428180", "class_list": "", "function": "Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilizing its protein level. Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006364 rRNA processing;GO:0097065 anterior head development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q80Y44-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99L04-1", "uniprot_id": "DHRS1_MOUSE", "mass": 34005.0, "length": 313, "protein_name": "Dehydrogenase/reductase SDR family member 1", "gene_name": "Dhrs1", "organism": "Mouse", "refseq_name": "dehydrogenase/reductase SDR family member 1", "refseq_ac": "NP_081095", "gene_names_uniprotkb": "Dhrs1; D14ertd484e", "gene_names_refseq": "1110029G07Rik; D14Ertd484e; Dhrs1", "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 1; 1.1.1.-; Protein SDR19C1; Short chain dehydrogenase/reductase family 19C member 1", "protein_names_refseq": "dehydrogenase/reductase (SDR family) member 1; dehydrogenase/reductase SDR family member 1; short chain dehydrogenase/reductase family 19C member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:52585)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "24129315;34428180;37453647;37507081", "class_list": "", "function": "NADPH-dependent oxidoreductase which catalyzes the reduction of some steroids (estrone, androstene-3,17-dione and cortisone) as well as prostaglandin E1, isatin and xenobiotics in vitro. May have a role in steroid and/or xenobiotic metabolism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THW0;Q9D148", "ec_number_list": "1.1.1.62;1.1.1.51;1.1.1.64;1.1.1.-;1.1.1.300;1.1.1.184", "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0047045 testosterone dehydrogenase (NADP+) activity;GO:0004090 carbonyl reductase (NADPH) activity;GO:0047881 estradiol 17-alpha-dehydrogenase [NAD(P)+] activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99L04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZA6-1", "uniprot_id": "NDE1_MOUSE", "mass": 38523.0, "length": 344, "protein_name": "Nuclear distribution protein nudE homolog 1", "gene_name": "Nde1", "organism": "Mouse", "refseq_name": "nuclear distribution protein nudE homolog 1 isoform b", "refseq_ac": "NP_001107557", "gene_names_uniprotkb": "Nde1; Nude", "gene_names_refseq": "2810027M15Rik; Nde1; Nude; mNudE", "protein_names_uniprotkb": "Nuclear distribution protein nudE homolog 1; NudE; mNudE", "protein_names_refseq": "nuclear distribution gene E homolog 1; nuclear distribution protein nudE homolog 1 isoform b; nuclear distribution protein nudE homolog 1", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); lissencephaly 4 (Disease Ontology:DOID:0112235); epilepsy (Disease Ontology:DOID:1826); Rubinstein-Taybi syndrome (Disease Ontology:DOID:1933)", "pathway": " (mmu:67203); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-5663220); (R-MMU-68877); (R-MMU-8854518); (R-MMU-9648025)", "pathway_count": 15, "publication_count": 9, "publication_id_list": "11163258;11163259;15473967;15939891;21529751;21750661;34428180;34518642;35011575", "class_list": "", "function": "FBW7 couples structural integrity with functional output of primary cilia. Publication Status: Online-Only, [RefSeq, PubMed]; Nde1 is essential for centrosome duplication and mitotic spindle assembly., [RefSeq, PubMed]; Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (By similarity)., [UniProtKB, UniProtKB, PubMed]; The Cytoplasmic Dynein Associated Protein NDE1 Regulates Osteoclastogenesis by Modulating M-CSF and RANKL Signaling Pathways. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBS6;Q3UIC1;Q9ERR0", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule;GO:0045202 synapse;GO:0005871 kinesin complex", "go_biological_process": "GO:0007059 chromosome segregation;GO:0016477 cell migration;GO:0030900 forebrain development;GO:0051301 cell division;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CZA6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CV60-1", "uniprot_id": "MLN_MOUSE", "mass": 5175.0, "length": 46, "protein_name": "Myoregulin", "gene_name": "Mrln", "organism": "Mouse", "refseq_name": "myoregulin", "refseq_ac": "NP_001291668", "gene_names_uniprotkb": "Mrln; Mln", "gene_names_refseq": "2310015B20Rik; Linc-RAM; Mln; Mrln", "protein_names_uniprotkb": "Myoregulin", "protein_names_refseq": "myoregulin", "tax_id": 10090, "disease": "", "pathway": " (mmu:69563)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;25640239;26816378;27923914;28091529;29364044;31449798;34428180", "class_list": "", "function": "Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle (PubMed:25640239, PubMed:26816378). Also inhibits the activity of ATP2A2/SERCA2 and ATP2A3/SERCA3 (PubMed:27923914, PubMed:31449798)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Linc-RAM regulates expression of myogenic genes by directly binding MyoD, which in turn promotes the assembly of the MyoD-Baf60c-Brg1 complex on the regulatory elements of target genes. Erratum:[Nat Commun. 2025 Dec 16;16(1):11151. doi: 10.1038/s41467-025-64348-4. PMID: 41397956] Publication Status: Online-Only, [RefSeq, PubMed]; Results demonstrate that the FGF2-mediated repression of Linc-RAM expression occurs through MyoD via the Ras/Raf/Mek/Erk signaling pathway during myogenic differentiation. Present data provide convincing evidence that Linc-RAM is a lineage-specific lncRNA that plays regulatory roles in modulating muscle cell differentiation via FGF2-mediated signaling., [RefSeq, PubMed]; The human and mouse MLN genes consist of three exons that span 16.5 and 15.0 kb, respectively, with the ORF located in exon 3; findings identify MLN as an important regulator of skeletal muscle physiology., [RefSeq, PubMed]; This gene encodes a small peptide that shares structural similarity to the small peptides sarcolipin and phospholamban, which are key regulators of sarcoplasmic reticulum Ca(2+)-ATPases (SERCAs). This protein is thought to have a similar function to these peptides, regulating Ca(2+) reuptake in the sarcoplasmic reticulum by inhibiting the Ca(2+) pump activity of SERCAs. [provided by RefSeq, Feb 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004857 enzyme inhibitor activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:1901895 negative regulation of ATPase-coupled calcium transmembrane transporter activity;GO:0009611 response to wounding;GO:1902081 negative regulation of calcium ion import into sarcoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CV60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4F0-1", "uniprot_id": "MCLN3_MOUSE", "mass": 63748.0, "length": 553, "protein_name": "Mucolipin-3", "gene_name": "Mcoln3", "organism": "Mouse", "refseq_name": "mucolipin-3", "refseq_ac": "NP_598921", "gene_names_uniprotkb": "Mcoln3", "gene_names_refseq": "6720490O21Rik; Mcoln3; TRPML3; Va", "protein_names_uniprotkb": "Mucolipin-3; TRPML3; Transient receptor potential channel mucolipin 3", "protein_names_refseq": "mucolipin-3; transient receptor potential channel mucolipin 3; varitint-waddler", "tax_id": 10090, "disease": "mucolipidosis type IV (Disease Ontology:DOID:0080490); glycoproteinosis (Disease Ontology:DOID:3343)", "pathway": " (mmu:171166); (R-MMU-3295583)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "12403827;17989217;18048323;18801844;21179200;21750661;24269818;26027738;29453205;34428180;35031603;35820727;36520788", "class_list": "", "function": "Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice. Publication Status: Online-Only, [RefSeq, PubMed]; Mice lacking both mucolipins 3 and 1, but not either one alone, experienced hearing loss as early as at 1 month of age., [RefSeq, PubMed]; Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:17989217). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (By similarity). Also permeable to Mg(2+), Na(+) and K(+) (PubMed:17989217). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth (PubMed:18801844). Involved in the regulation of autophagy. Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (PubMed:24269818). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Study shows that, when uropathogenic E. coli infect bladder epithelial cells, they are targeted by autophagy but avoid degradation because of their capacity to neutralize lysosomal pH. This change is detected by TRPML3, TRPML3 activation then spontaneously initiates lysosome exocytosis, resulting in expulsion of exosome-encased bacteria., [RefSeq, PubMed]; Whole-body analysis of TRPML3 (MCOLN3) expression using a GFP-reporter mouse model reveals widespread expression in secretory cells and endocrine glands. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BS73;Q8BSG1;Q8CDB2", "ec_number_list": "1.8.-.-;2.7.11.1", "go_molecular_function": "GO:0072345 NAADP-sensitive calcium-release channel activity;GO:0008289 lipid binding;GO:0005267 potassium channel activity;GO:0005253 monoatomic anion channel activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8R4F0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09008-1", "uniprot_id": "MFNG_MOUSE", "mass": 36200.0, "length": 321, "protein_name": "Beta-1,3-N-acetylglucosaminyltransferase manic fringe", "gene_name": "Mfng", "organism": "Mouse", "refseq_name": "beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform 1", "refseq_ac": "NP_032621", "gene_names_uniprotkb": "Mfng", "gene_names_refseq": "Mfng", "protein_names_uniprotkb": "Beta-1,3-N-acetylglucosaminyltransferase manic fringe; 2.4.1.222; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase", "protein_names_refseq": "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform 1; beta-1,3-N-acetylglucosaminyltransferase manic fringe; manic fringe homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:17305)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10935626;16221665;16964258;26495903;28089369;9187150;9207795", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (PubMed:10935626). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (PubMed:10935626, PubMed:28089369)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.222", "go_molecular_function": "GO:0046872 metal ion binding;GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0045747 positive regulation of Notch signaling pathway;GO:0007389 pattern specification process;GO:0002315 marginal zone B cell differentiation;GO:0001825 blastocyst formation;GO:0008593 regulation of Notch signaling pathway", "synthesized_glycan_count": 19, "hit_score": 0.8, "record_id": "O09008-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2VPU4-1", "uniprot_id": "MLXIP_MOUSE", "mass": 100804.0, "length": 917, "protein_name": "MLX-interacting protein", "gene_name": "Mlxip", "organism": "Mouse", "refseq_name": "MLX-interacting protein isoform 2", "refseq_ac": "NP_598678", "gene_names_uniprotkb": "Mlxip; Mir", "gene_names_refseq": "Mir; Mlxip; bHLHe36", "protein_names_uniprotkb": "MLX-interacting protein; Transcriptional activator MondoA", "protein_names_refseq": "MLX-interacting protein isoform 2; Mlx interactor; transcriptional activator MondoA", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:208104)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11073985;16644671;21183079;21750661;25428506;27500491;29282201;29779826;30084848;31219806;31287806;32782141;32848054;33901495;34428180;34678516;36084651;36210013;36852467;40885482", "class_list": "", "function": "Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation (By similarity) (PubMed:11073985, PubMed:16644671). Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (PubMed:29779826)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Data (including data from studies in knockout mice) suggest that MondoA shuttles to nucleus of pancreatic beta-cells where it is required for induction of glucose-responsive genes arrestin domain-containing protein 4 (Arrdc4) and thioredoxin interacting protein (Txnip)., [RefSeq, PubMed]; MondoA drives muscle lipid accumulation and insulin resistance. Publication Status: Online-Only, [RefSeq, PubMed]; MondoA-Thioredoxin-Interacting Protein Axis Maintains Regulatory T-Cell Identity and Function in Colorectal Cancer Microenvironment., [RefSeq, PubMed]; MondoA-directed programs have a key role in the coordinated control of myocyte lipid balance and insulin signaling, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q6NXJ4;Q6P9J8;Q8C8C6;Q8VI53", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006913 nucleocytoplasmic transport;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q2VPU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SWW4-1", "uniprot_id": "MED13_MOUSE", "mass": 238591.0, "length": 2171, "protein_name": "Mediator of RNA polymerase II transcription subunit 13", "gene_name": "Med13", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 13", "refseq_ac": "NP_001074400", "gene_names_uniprotkb": "Med13; Kiaa0593; Thrap1; Trap240", "gene_names_refseq": "1110067M05Rik; D030023K18; Med13; Thrap1; Trap240", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 13; Thyroid hormone receptor-associated protein 1; Thyroid hormone receptor-associated protein complex 240 kDa component; Trap240", "protein_names_refseq": "Zmediator complex subunit 13; mediator of RNA polymerase II transcription subunit 13; mediator of RNA polymerase II transcription, subunit 13; thyroid hormone receptor associated protein 1; thyroid hormone receptor associated protein, 240 kDa subunit; thyroid hormone receptor-associated protein complex 240 kDa component", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 61 (Disease Ontology:DOID:0061034); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:327987)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21183079;25428506;30084848;31219806;34428180;36543134;40997131", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB]; MED13 and glycolysis are conserved modifiers of alpha-synuclein-associated neurodegeneration., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3V3P6;Q6ZQ90", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046966 nuclear thyroid hormone receptor binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016592 mediator complex;GO:1990508 CKM complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5SWW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQI9-1", "uniprot_id": "MED30_MOUSE", "mass": 20358.0, "length": 178, "protein_name": "Mediator of RNA polymerase II transcription subunit 30", "gene_name": "Med30", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 30", "refseq_ac": "NP_081488", "gene_names_uniprotkb": "Med30; Thrap6; Trap25", "gene_names_refseq": "1810038N03Rik; 2510044J04Rik; Med30; TRAP25; Thrap6", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 30; Mediator complex subunit 30; Thyroid hormone receptor-associated protein 6; Thyroid hormone receptor-associated protein complex 25 kDa component; Trap25", "protein_names_refseq": "TRAP/Mediator complex component TRAP25; mediator of RNA polymerase II transcription subunit 30; thyroid hormone receptor associated protein 6; thyroid hormone receptor-associated protein complex 25 kDa component", "tax_id": 10090, "disease": "", "pathway": " (mmu:69790)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "25605945;26110885;34506481", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB]; MED30 was overexpressed in gastric cancer tissues and cell lines. Moreover, MED30 overexpression increased the proliferation, migration, and invasion of gastric cancer cells Publication Status: Online-Only, [RefSeq, PubMed]; Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0061630 ubiquitin protein ligase activity;GO:0046966 nuclear thyroid hormone receptor binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000151 ubiquitin ligase complex;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0019827 stem cell population maintenance;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0X0-1", "uniprot_id": "MED20_MOUSE", "mass": 23192.0, "length": 212, "protein_name": "Mediator of RNA polymerase II transcription subunit 20", "gene_name": "Med20", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 20 isoform 1", "refseq_ac": "NP_064432", "gene_names_uniprotkb": "Med20; Trfp", "gene_names_refseq": "1110011O05Rik; 2410115I17Rik; Med20; Trfp", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 20; Mediator complex subunit 20; TRF-proximal protein homolog", "protein_names_refseq": "Trf (TATA binding protein-related factor)-proximal protein homolog; mediator of RNA polymerase II transcription subunit 20 isoform 1; mediator of RNA polymerase II transcription subunit 20; ubiquitin specific protease 49", "tax_id": 10090, "disease": "", "pathway": " (mmu:56771)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12037571;31219806;34428180;36210013", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJQ7;Q3V418;Q6PAR6", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000151 ubiquitin ligase complex;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination;GO:0035914 skeletal muscle cell differentiation;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9R0X0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0I8-1", "uniprot_id": "MRT4_MOUSE", "mass": 27546.0, "length": 239, "protein_name": "mRNA turnover protein 4 homolog", "gene_name": "Mrto4", "organism": "Mouse", "refseq_name": "mRNA turnover protein 4 homolog isoform 1", "refseq_ac": "NP_001277739", "gene_names_uniprotkb": "Mrto4; Mrt4", "gene_names_refseq": "2610012O22Rik; Mg684; Mrt4; Mrto4", "protein_names_uniprotkb": "mRNA turnover protein 4 homolog; Ribosome assembly factor Mrto4", "protein_names_refseq": "MRT4, mRNA turnover 4, homolog; mRNA turnover 4, homolog; mRNA turnover protein 4 homolog isoform 1; mRNA turnover protein 4 homolog; muscle protein684; ribosome assembly factor Mrto4", "tax_id": 10090, "disease": "", "pathway": " (mmu:69902)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;34428180", "class_list": "", "function": "Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99JR7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0006364 rRNA processing;GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D0I8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVG9-1", "uniprot_id": "MS3L1_MOUSE", "mass": 60292.0, "length": 525, "protein_name": "MSL complex subunit 3", "gene_name": "Msl3", "organism": "Mouse", "refseq_name": "MSL complex subunit 3 isoform 5", "refseq_ac": "NP_034962", "gene_names_uniprotkb": "Msl3; Msl31; Msl3l1", "gene_names_refseq": "Msl31; Msl3l1; Msl3", "protein_names_uniprotkb": "MSL complex subunit 3; MSL3-like 1; Male-specific lethal 3 homolog; Male-specific lethal-3 homolog 1; Male-specific lethal-3 protein-like 1", "protein_names_refseq": "MSL complex subunit 3 isoform 5; male-specific lethal 3 homolog; male-specific lethal-3 homolog 1; male-specific lethal-3 protein-like 1", "tax_id": 10090, "disease": "Basilicata-Akhtar syndrome (Disease Ontology:DOID:0111838)", "pathway": " (mmu:17692); (R-MMU-3214847)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10395802;11668396;21183079;21217699;24842875;28609438;31219806;34428180;37847071", "class_list": "", "function": "Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice, [RefSeq, PubMed]; Data show that complete removal of paternally expressed gene 3 (PEG3) resulted in up-regulation of male-specific lethal 1 (Msl1) and male-specific lethal 3 (Msl3). Publication Status: Online-Only, [RefSeq, PubMed]; Loss of function of male-specific lethal 3 (Msl3) does not affect spermatogenesis in rodents., [RefSeq, PubMed]; Msl1 interacts with Msl3 as an extended chain forming an extensive hydrophobic interface, whereas the Msl1-MOF interface involves electrostatic interactions between the HAT domain and a long helix of Msl1., [RefSeq, PubMed]; Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:24842875). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (By similarity). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome. X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (PubMed:24842875). Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. May play a role X inactivation in females (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AUJ7;B1AUJ8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0140566 histone reader activity;GO:0140046 histone H4K16ac reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035267 NuA4 histone acetyltransferase complex;GO:0072487 MSL complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WVG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1AY10-1", "uniprot_id": "NFX1_MOUSE", "mass": 123811.0, "length": 1114, "protein_name": "Transcriptional repressor NF-X1", "gene_name": "Nfx1", "organism": "Mouse", "refseq_name": "transcriptional repressor NF-X1 isoform 2", "refseq_ac": "NP_001277377", "gene_names_uniprotkb": "Nfx1", "gene_names_refseq": "1300017N15Rik; 3000003M19Rik; NFX.1; Nfx1; TEG-42; Tex42", "protein_names_uniprotkb": "Transcriptional repressor NF-X1; 2.3.2.-; Nuclear transcription factor, X box-binding protein 1; m-Nfx.1", "protein_names_refseq": "nuclear transcription factor, X box-binding protein 1; testis expressed gene 42; transcriptional repressor NF-X1 isoform 2; transcriptional repressor NF-X1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74164)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12047746;21183079;35820727", "class_list": "", "function": "Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Together with PABPC1 or PABPC4, acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2A7;Q3UK95;Q3UMW1;Q7TPT4;Q8CC59;Q9DBC8;Q9JKW7", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0051865 protein autoubiquitination;GO:0045347 negative regulation of MHC class II biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B1AY10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06837-1", "uniprot_id": "NEUM_MOUSE", "mass": 23632.0, "length": 227, "protein_name": "Neuromodulin", "gene_name": "Gap43", "organism": "Mouse", "refseq_name": "neuromodulin", "refseq_ac": "NP_032109", "gene_names_uniprotkb": "Gap43; Basp2", "gene_names_refseq": "B-50; Basp2; GAP-43; Gap43", "protein_names_uniprotkb": "Neuromodulin; Axonal membrane protein GAP-43; Calmodulin-binding protein P-57; Growth-associated protein 43", "protein_names_refseq": "axonal membrane protein GAP-43; brain abundant, membrane attached signal protein 2; calmodulin-binding protein P-57; growth accentuating protein 43; neuromodulin", "tax_id": 10090, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:14432); (R-MMU-373760)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11433297;11573004;15345747;16452087;16522636;1828073;18322192;18493953;21183079;22645316;2442159;27875292;28111162;32848054;33832520", "class_list": "", "function": "This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0001786 phosphatidylserine binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0035727 lysophosphatidic acid binding", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0016198 axon choice point recognition;GO:0040008 regulation of growth;GO:0010996 response to auditory stimulus;GO:0042246 tissue regeneration;GO:0051489 regulation of filopodium assembly", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P06837-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43688-1", "uniprot_id": "NKX26_MOUSE", "mass": 31597.0, "length": 289, "protein_name": "Homeobox protein Nkx-2.6", "gene_name": "Nkx2-6", "organism": "Mouse", "refseq_name": "homeobox protein Nkx-2.6 isoform 1", "refseq_ac": "NP_035050", "gene_names_uniprotkb": "Nkx2-6; Nkx-2.6; Nkx2f", "gene_names_refseq": "Nkx-2.6; Nkx2-6; Nkx2.6; Tix; tinman", "protein_names_uniprotkb": "Homeobox protein Nkx-2.6; Homeobox protein NK-2 homolog F", "protein_names_refseq": "Drosophila NK2 transcription factor related, locus 6; homeobox protein NK-2 homolog F; homeobox protein Nkx-2.6 isoform 1; homeobox protein Nkx-2.6", "tax_id": 10090, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); ventricular septal defect (Disease Ontology:DOID:1657); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:18092)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10733590;11390666;35820727;7904557;9486544;9545560", "class_list": "", "function": "Acts as a transcriptional activator (By similarity). In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development (PubMed:10733590, PubMed:11390666)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P43688-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P5H2-1", "uniprot_id": "NEST_MOUSE", "mass": 207124.0, "length": 1864, "protein_name": "Nestin", "gene_name": "Nes", "organism": "Mouse", "refseq_name": "nestin", "refseq_ac": "NP_057910", "gene_names_uniprotkb": "Nes", "gene_names_refseq": "ESTM46; Ifaprc2; Marc2; Nes; RC2", "protein_names_uniprotkb": "Nestin", "protein_names_refseq": "intermediate filament protein; intermediate filament-associated protein RC2; nestin", "tax_id": 10090, "disease": "brain ischemia (Disease Ontology:DOID:2316); nephrosis (Disease Ontology:DOID:2527); acute kidney failure (Disease Ontology:DOID:3021); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (mmu:18008)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10842089;15345747;17242355;20963821;21183079;22645316;24788674;25428506;34203471;34428180;7542682", "class_list": "", "function": "Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division (By similarity). Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 33, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1E2I2;Q80X00;Q8BPH7;Q9CV43;Q9R0C4", "ec_number_list": "", "go_molecular_function": "GO:0019215 intermediate filament binding;GO:0031730 CCR5 chemokine receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005882 intermediate filament;GO:0045111 intermediate filament cytoskeleton", "go_biological_process": "GO:0007399 nervous system development;GO:0000086 G2/M transition of mitotic cell cycle;GO:0043086 negative regulation of catalytic activity;GO:0043524 negative regulation of neuron apoptotic process;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6P5H2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923S6-1", "uniprot_id": "NEUL1_MOUSE", "mass": 61778.0, "length": 574, "protein_name": "E3 ubiquitin-protein ligase NEURL1", "gene_name": "Neurl1a; Neurl1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase NEURL1 isoform 2", "refseq_ac": "NP_001156952", "gene_names_uniprotkb": "Neurl1a; Neurl1; Neurl1a; Neurl", "gene_names_refseq": "2410129E16Rik; Neu1; Neur1; Neurl1a; Neurl1; Neurl; Nlz; Rnf67", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase NEURL1; 2.3.2.27; Neuralized-like protein 1A; Neuralized1; RING-type E3 ubiquitin transferase NEURL1; m-neu1; m-neuralized 1", "protein_names_refseq": "E3 ubiquitin-protein ligase NEURL1 isoform 2; E3 ubiquitin-protein ligase NEURL1; RING-type E3 ubiquitin transferase NEURL1; m-neu1; m-neuralized 1; neuralized homolog 1A; neuralized-like homolog; neuralized-like protein 1A; neuralized-like protein 1; neuralized1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18011)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11481456;11585928;11997106;18077452;19723503;21750661;22153079;26276215;32644222", "class_list": "", "function": "Fe65 negatively regulates Jagged1 signaling by decreasing Jagged1 protein stability through the E3 ligase Neuralized-like 1., [RefSeq, PubMed]; Molecular cloning, base sequence, amino acid sequence, and embryo tissue localization, [RefSeq, PubMed]; Neur1 and Neur2 are required for hippocampus-dependent spatial memory and synaptic plasticity., [RefSeq, PubMed]; Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway., [UniProtKB, PubMed, PubMed]; These results suggest a model whereby Neuralized1-dependent ubiquitination facilitates hippocampal plasticity and hippocampal-dependent memory storage by modulating the activity of CPEB3 and CPEB3-dependent protein synthesis and synapse formation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91ZT6;Q9CWF1;Q9QWF1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0045182 translation regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine;GO:0043204 perikaryon;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0090129 positive regulation of synapse maturation;GO:0051491 positive regulation of filopodium assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q923S6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ45-1", "uniprot_id": "NENF_MOUSE", "mass": 18904.0, "length": 171, "protein_name": "Neudesin", "gene_name": "Nenf", "organism": "Mouse", "refseq_name": "neudesin precursor", "refseq_ac": "NP_079700", "gene_names_uniprotkb": "Nenf; Spuf", "gene_names_refseq": "1110060M21Rik; Nenf; SCIRP10; Spuf", "protein_names_uniprotkb": "Neudesin; Neuron-derived neurotrophic factor; SPUF protein; Secreted protein of unknown function", "protein_names_refseq": "SCIRP10-related protein; Spinal cord injury related protein 10; neudesin precursor; neudesin; secreted protein of unknown function", "tax_id": 10090, "disease": "", "pathway": " (mmu:66208)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15605373;16547973;18056703;19351598;23576617;25955136;31536960;36450531;38272969", "class_list": "", "function": "A secretory protein neudesin regulates splenic red pulp macrophages in erythrophagocytosis and iron recycling. Publication Status: Online-Only, [RefSeq, PubMed]; Acts as a neurotrophic factor in postnatal mature neurons, enhancing neuronal survival (PubMed:15605373, PubMed:31536960). Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocytes (PubMed:16547973). Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (PubMed:15605373, PubMed:16547973). Neurotrophic activity is enhanced by binding to heme (PubMed:18056703). Also acts as an anorexigenic neurotrophic factor that contributes to energy balance (PubMed:23576617)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Identification of neudesin, a novel mouse secreted protein showing neurotrophic activity in primary cultured mouse neurons, [RefSeq, PubMed]; Neudesin is the first extracellular heme-binding protein that shows signal transducing activity by itself. The present findings may shed new light on the function of extracellular heme-binding proteins, [RefSeq, PubMed]; Neudesin, which may be a negative regulator of sympathetic activity, could represent a novel regulator of the development of obesity and obesity-related metabolic dysfunctions. Publication Status: Online-Only, [RefSeq, PubMed]; Neuron-derived neurotrophic factor (NENF) is an important central modulator of food intake., [RefSeq, PubMed]; Testicular Hypoplasia with Normal Fertility in Neudesin-Knockout Mice., [RefSeq, PubMed]; The present findings have revealed new potential roles of neudesin in neural cell proliferation and neuronal differentiation., [RefSeq, PubMed]; These findings suggest that neudesin plays a critical role in the early stage of adipocyte differentiation in which C/EBPbeta induces PPARgamma and C/EBPalpha expressions, by controlling the MAPK pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5TM91", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0032099 negative regulation of appetite", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CQ45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0T1-1", "uniprot_id": "NH2L1_MOUSE", "mass": 14174.0, "length": 128, "protein_name": "NHP2-like protein 1", "gene_name": "Snu13", "organism": "Mouse", "refseq_name": "NHP2-like protein 1", "refseq_ac": "NP_035612", "gene_names_uniprotkb": "Snu13; Nhp2l1; Ssfa1", "gene_names_refseq": "FA-1; Fta1; Nhp2l1; Snu13; Ssfa1", "protein_names_uniprotkb": "NHP2-like protein 1; FA-1; Fertilization antigen 1; High mobility group-like nuclear protein 2 homolog 1; Sperm-specific antigen 1; U4/U6.U5 small nuclear ribonucleoprotein SNU13; U4/U6.U5 tri-snRNP 15.5 kDa protein", "protein_names_refseq": "NHP2 non-histone chromosome protein 2-like 1; NHP2-like protein 1; U4/U6.U5 small nuclear ribonucleoprotein SNU13; U4/U6.U5 tri-snRNP 15.5 kDa protein; fertilization antigen-1; high mobility group-like nuclear protein 2 homolog 1; sperm specific antigen 1", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:20826); (R-MMU-6791226); (R-MMU-72163)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "23806337;34428180;35820727;39627609;9114055", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08754;Q3UY64", "ec_number_list": "", "go_molecular_function": "GO:0030621 U4 snRNA binding;GO:0003723 RNA binding;GO:0051117 ATPase binding;GO:0030622 U4atac snRNA binding;GO:0034511 U3 snoRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0005681 spliceosomal complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007338 single fertilization;GO:0000398 mRNA splicing, via spliceosome;GO:0000492 box C/D snoRNP assembly;GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D0T1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1J2-1", "uniprot_id": "NEK4_MOUSE", "mass": 88994.0, "length": 792, "protein_name": "Serine/threonine-protein kinase Nek4", "gene_name": "Nek4", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase Nek4 isoform 2", "refseq_ac": "NP_001295257", "gene_names_uniprotkb": "Nek4; Stk2", "gene_names_refseq": "Nek4; Stk2", "protein_names_uniprotkb": "Serine/threonine-protein kinase Nek4; 2.7.11.1; Never in mitosis A-related kinase 4; NimA-related protein kinase 4; Serine/threonine-protein kinase 2", "protein_names_refseq": "serine/threonine-protein kinase 2; serine/threonine-protein kinase Nek4 isoform 2; serine/threonine-protein kinase Nek4", "tax_id": 10090, "disease": "", "pathway": " (mmu:23955); (R-MMU-2672351); (R-MMU-383280)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10393247;10529384;20103636;21183079;21750661;31219806;34418053;39448584;40021952", "class_list": "", "function": "Data show that after Taxol treatment, Nek4 promoted microtubule outgrowth, whereas Nek4 deficiency impaired G(2)-M arrest and decreased formation of mitotic-like asters., [RefSeq, PubMed]; NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice. Publication Status: Online-Only, [RefSeq, PubMed]; Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage (By similarity). Protein kinase that seems to act exclusively upon threonine residues., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "O35673;Q9R1J1", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.3.2.26;2.3.2.36;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0035253 ciliary rootlet;GO:0036064 ciliary basal body;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0051301 cell division;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9Z1J2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHI9-1", "uniprot_id": "S40A1_MOUSE", "mass": 62702.0, "length": 570, "protein_name": "Ferroportin", "gene_name": "Slc40a1", "organism": "Mouse", "refseq_name": "ferroportin", "refseq_ac": "NP_058613", "gene_names_uniprotkb": "Slc40a1; Fpn1; Ireg1; Slc11a3; Slc39a1", "gene_names_refseq": "Dusg; Fpn1; IREG1; MTP1; MTP; Ol5; Pcm; Slc11a3; Slc39a1; Slc40a1", "protein_names_uniprotkb": "Ferroportin; Ferroportin-1; Iron-regulated transporter 1; MTP1; Metal transporter protein 1; Solute carrier family 40 member 1", "protein_names_refseq": "SLC11A3 iron transporter; duodenal-specific; ferroportin 1; ferroportin1; ferroportin; iron-regulated transporter 1; metal transporter protein 1; metal transporting protein 1; polycythaemia; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3; solute carrier family 39 (iron-regulated transporter), member 1; solute carrier family 40 member 1", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); hemochromatosis type 4 (Disease Ontology:DOID:0111028); iron deficiency anemia (Disease Ontology:DOID:11758); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:53945); (R-MMU-425410); (R-MMU-917937)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10693807;10747949;10882071;16054062;26495903;29599243;30084848;30213870;30779550;30888356;33895792;34428180", "class_list": "", "function": "Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed:16054062, PubMed:30213870). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (PubMed:16054062, PubMed:30213870). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHZ9;Q8BME5;Q8BUM5;Q9JIM9;Q9JKP4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0017046 peptide hormone binding;GO:0015093 ferrous iron transmembrane transporter activity;GO:0005381 iron ion transmembrane transporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0002260 lymphocyte homeostasis;GO:0034755 iron ion transmembrane transport;GO:0060345 spleen trabecula formation;GO:1903988 iron ion export across plasma membrane;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JHI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXE7-1", "uniprot_id": "TBL1X_MOUSE", "mass": 56802.0, "length": 527, "protein_name": "F-box-like/WD repeat-containing protein TBL1X", "gene_name": "Tbl1x", "organism": "Mouse", "refseq_name": "F-box-like/WD repeat-containing protein TBL1X", "refseq_ac": "NP_065626", "gene_names_uniprotkb": "Tbl1x; Tbl1", "gene_names_refseq": "5330429M20; Tbl1x; Tbl1", "protein_names_uniprotkb": "F-box-like/WD repeat-containing protein TBL1X; Transducin beta-like protein 1X", "protein_names_refseq": "F-box-like/WD repeat-containing protein TBL1X; transducin beta-like protein 1X", "tax_id": 10090, "disease": "sensory system disease (Disease Ontology:DOID:0050155); Y-linked deafness 2 (Disease Ontology:DOID:0111758); congenital nongoitrous hypothyroidism 8 (Disease Ontology:DOID:0111837)", "pathway": " (mmu:21372); (R-MMU-350054); (R-MMU-400206); (R-MMU-9029569); (R-MMU-9707564); (R-MMU-9841922)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "10330347;14980219;26070566;28348241;29794369;34428180;36852467;38381448;38639717;40021952;40885482;40997131", "class_list": "", "function": "F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity)., [UniProtKB, UniProtKB]; Mutant Tbl1x male mice have a short life span and do not breed: unexpected findings. Publication Status: Online-Only, [RefSeq, PubMed]; TBLR1 and TBL1 have roles in specific nuclear receptor-mediated gene activation events, [RefSeq, PubMed]; Tbl1 promotes Wnt-beta-catenin signaling-induced degradation of the Tcf7l1 protein in mouse embryonic stem cells., [RefSeq, PubMed]; These results suggest that TBL1X is needed for the full activation of TRH and TSHbeta gene promoters by unliganded thyroid hormone receptors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMM0;Q8BYQ4;Q8C0A1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0005667 transcription regulator complex;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9QXE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810S1-1", "uniprot_id": "MCUB_MOUSE", "mass": 39799.0, "length": 345, "protein_name": "Calcium uniporter regulatory subunit MCUb, mitochondrial", "gene_name": "Mcub", "organism": "Mouse", "refseq_name": "calcium uniporter regulatory subunit MCUb, mitochondrial isoform 2", "refseq_ac": "NP_001280573", "gene_names_uniprotkb": "Mcub; Ccdc109b", "gene_names_refseq": "9030408N13Rik; Ccdc109b; Mcub", "protein_names_uniprotkb": "Calcium uniporter regulatory subunit MCUb, mitochondrial; Coiled-coil domain-containing protein 109B; MCUb", "protein_names_refseq": "calcium uniporter regulatory subunit MCUb, mitochondrial isoform 2; calcium uniporter regulatory subunit MCUb, mitochondrial; coiled-coil domain containing 109B; coiled-coil domain-containing protein 109B; mitochondrial calcium uniporter regulatory subunit MCUb", "tax_id": 10090, "disease": "", "pathway": " (mmu:66815); (R-MMU-8949215); (R-MMU-8949664)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21750661;23900286;31533452;34428180;34726954;37061131;37976157", "class_list": "", "function": "Functional characterization of the MCUb protein; shows that it inhibits mitochondrial calcium uptake, [RefSeq, PubMed]; MCUB-dependent changes in mitochondrial calcium uniporter stoichiometry are a prominent regulatory mechanism to modulate mitochondrial Ca(2+) uptake and cardiac myocyte cellular physiology., [RefSeq, PubMed]; MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle., [RefSeq, PubMed]; Mitochondrial calcium uniporter b deletion inhibits platelet function and reduces susceptibility to arterial thrombosis., [RefSeq, PubMed]; Negative regulator of the mitochondrial calcium uniporter (MCU), a channel that mediates calcium uptake into the mitochondrial matrix (PubMed:23900286, PubMed:31533452, PubMed:37976157). MCUB is required to limit mitochondrial calcium overload during stress (PubMed:31533452, PubMed:37976157). Acts as a dominant-negative regulator that displaces MCU from the functional uniplex complex and thereby decreases the association of calcium sensors MICU1 and MICU2, preventing channel gating (PubMed:31533452). Mitochondrial calcium homeostasis plays key roles in mitochondrial metabolism (PubMed:23900286, PubMed:31533452). Acts as an important regulator of mitochondrial metabolism in response to stress in muscle cells: induced in response to fasting, leading to restrict mitochondrial calcium uptake, resulting in reprogramming of mitochondria toward fatty acid oxidation preference (PubMed:37976157). Acts as a regulator of macrophage polarization during skeletal muscle regeneration: inhibition of mitochondrial calcium uptake drives differentiation of macrophages with anti-inflammatory profile, promoting the differentiation and fusion of satellite cells (PubMed:34726954)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4A9;Q9CSE7;Q9D345", "ec_number_list": "", "go_molecular_function": "GO:0019855 calcium channel inhibitor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0016020 membrane;GO:0034704 calcium channel complex", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0006851 mitochondrial calcium ion transmembrane transport;GO:0036444 calcium import into the mitochondrion;GO:0051560 mitochondrial calcium ion homeostasis;GO:0043030 regulation of macrophage activation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q810S1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70166-1", "uniprot_id": "CPEB1_MOUSE", "mass": 61917.0, "length": 561, "protein_name": "Cytoplasmic polyadenylation element-binding protein 1", "gene_name": "Cpeb1", "organism": "Mouse", "refseq_name": "cytoplasmic polyadenylation element-binding protein 1 isoform 1", "refseq_ac": "NP_001239454", "gene_names_uniprotkb": "Cpeb1; Cpeb", "gene_names_refseq": "Cpe-bp1; Cpeb1; Cpeb; mCPEB; mCpeb-1", "protein_names_uniprotkb": "Cytoplasmic polyadenylation element-binding protein 1; CPE-BP1; CPE-binding protein 1; mCPEB-1; mCPEB", "protein_names_refseq": "CPE-binding protein 1; cytoplasmic polyadenylation element-binding protein 1 isoform 1", "tax_id": 10090, "disease": "portal hypertension (Disease Ontology:DOID:10762); primary biliary cholangitis (Disease Ontology:DOID:12236); glioblastoma (Disease Ontology:DOID:3068); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (mmu:12877)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "11526086;11980711;12629046;12815066;12871996;15175389;15944388;16314516;16705177;17567800;17927953;18299400;21750661;25428506;30084848;30779550;34203471;34428180;35820727;37218508;38785133;8962099;9856468", "class_list": "", "function": "Multiple intersecting pathways are involved in CPEB1 phosphorylation and regulation of translation during mouse oocyte meiosis., [RefSeq, PubMed]; PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1., [RefSeq, PubMed]; Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress (By similarity). Required for cell cycle progression, specifically for prophase entry (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5P9", "ec_number_list": "", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0046872 metal ion binding;GO:0008135 translation factor activity, RNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0006417 regulation of translation;GO:0008285 negative regulation of cell population proliferation;GO:0010976 positive regulation of neuron projection development;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P70166-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C708-1", "uniprot_id": "CP054_MOUSE", "mass": 24532.0, "length": 225, "protein_name": "Transmembrane protein C16orf54 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "transmembrane protein C16orf54 homolog", "refseq_ac": "NP_849232", "gene_names_uniprotkb": "", "gene_names_refseq": "AI467606", "protein_names_uniprotkb": "Transmembrane protein C16orf54 homolog", "protein_names_refseq": "transmembrane protein C16orf54 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:101602)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19144319;21183079;21498670;26495903", "class_list": "", "function": "These findings indicate that AI467606 is a novel transcriptional target of RUNX1/AML1 at the onset of hematopoietic development that is extensively expressed within the hematopoietic system, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6P3A6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8C708-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60838-1", "uniprot_id": "DVL2_MOUSE", "mass": 78861.0, "length": 736, "protein_name": "Segment polarity protein dishevelled homolog DVL-2", "gene_name": "Dvl2", "organism": "Mouse", "refseq_name": "segment polarity protein dishevelled homolog DVL-2", "refseq_ac": "NP_031914", "gene_names_uniprotkb": "Dvl2", "gene_names_refseq": "Dvl2", "protein_names_uniprotkb": "Segment polarity protein dishevelled homolog DVL-2; DSH homolog 2; Dishevelled-2", "protein_names_refseq": "DSH homolog 2; dishevelled 2, dsh homolog; dishevelled-2; segment polarity protein dishevelled homolog DVL-2", "tax_id": 10090, "disease": "dextro-looped transposition of the great arteries (Disease Ontology:DOID:0060770); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:13543); (R-MMU-201688); (R-MMU-2028269); (R-MMU-4086400); (R-MMU-4608870); (R-MMU-4641258); (R-MMU-4641262); (R-MMU-5099900); (R-MMU-5663220); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 11, "publication_count": 12, "publication_id_list": "15262978;15456783;17199046;20947020;21183079;21189423;22609948;23708998;25823377;27214281;31219806;8887313", "class_list": "", "function": "Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TN14", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007507 heart development;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046330 positive regulation of JNK cascade;GO:0061098 positive regulation of protein tyrosine kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q60838-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DP60-1", "uniprot_id": "LYNX1_MOUSE", "mass": 12835.0, "length": 116, "protein_name": "Ly-6/neurotoxin-like protein 1", "gene_name": "Lynx1", "organism": "Mouse", "refseq_name": "ly-6/neurotoxin-like protein 1 precursor", "refseq_ac": "NP_035968", "gene_names_uniprotkb": "Lynx1", "gene_names_refseq": "Lynx1; SLURP-2", "protein_names_uniprotkb": "Ly-6/neurotoxin-like protein 1; GC26", "protein_names_refseq": "GC26; ly-6/neurotoxin-like protein 1 precursor; ly-6/neurotoxin-like protein 1; secreted Ly-6/uPAR domain-containing protein 2; secreted Ly-6/uPAR-related protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:23936)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10402197;11906696;16950157;21071629;21750661;25193667;37833597", "class_list": "", "function": "Accumulation of beta-Amyloid Leads to a Decrease in Lynx1 and Lypd6B Expression in the Hippocampus and Increased Expression of Proinflammatory Cytokines in the Hippocampus and Blood Serum., [RefSeq, PubMed]; Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs) (PubMed:10402197). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs (PubMed:10402197, PubMed:11906696). Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR (PubMed:25193667). In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs (By similarity). Prevents plasticity in the primary visual cortex late in life (PubMed:21071629)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Results show that lynx1 colocalizes with nAChRs on CNS neurons and physically associates with nAChRs and enhances receptor desensitization, resulting in a novel type of functional modulation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08EF7;Q3TRB5;Q9WVC2", "ec_number_list": "", "go_molecular_function": "GO:0030548 acetylcholine receptor regulator activity;GO:0033130 acetylcholine receptor binding;GO:0008200 ion channel inhibitor activity;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0095500 acetylcholine receptor signaling pathway;GO:0099601 regulation of neurotransmitter receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P0DP60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVN9-1", "uniprot_id": "MAEL_MOUSE", "mass": 49371.0, "length": 434, "protein_name": "Protein maelstrom homolog", "gene_name": "Mael", "organism": "Mouse", "refseq_name": "protein maelstrom homolog", "refseq_ac": "NP_780505", "gene_names_uniprotkb": "Mael", "gene_names_refseq": "4933405K18Rik; Mael", "protein_names_uniprotkb": "Protein maelstrom homolog", "protein_names_refseq": "maelstrom homolog; protein maelstrom homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:98558)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16787967;18694567;20011505;21750661;28254886;31219806", "class_list": "", "function": "Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; This study demonstrates that MAEL, a nuage component, is indispensable for the silencing of transposable elements (TEs) and identifies the initiation of meiosis as an important step in (TE) control in the male germline., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0009566 fertilization;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BVN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70299-1", "uniprot_id": "MB211_MOUSE", "mass": 40956.0, "length": 359, "protein_name": "Putative nucleotidyltransferase MAB21L1", "gene_name": "Mab21l1", "organism": "Mouse", "refseq_name": "putative nucleotidyltransferase MAB21L1", "refseq_ac": "NP_034880", "gene_names_uniprotkb": "Mab21l1; Mab21", "gene_names_refseq": "Mab21l1", "protein_names_uniprotkb": "Putative nucleotidyltransferase MAB21L1; 2.7.7.-; Protein mab-21-like 1", "protein_names_refseq": "protein mab-21-like 1; putative nucleotidyltransferase MAB21L1", "tax_id": 10090, "disease": "microphthalmia (Disease Ontology:DOID:10629)", "pathway": " (mmu:17116)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10349626;10556287;11857508;12642482;17167770;29156428;36413568;37750449", "class_list": "", "function": "External genitalia phenotypes of a Mab21l1-null mouse model for cerebellar, ocular, craniofacial, and genital (COFG) syndrome., [RefSeq, PubMed]; Monoallelic variants resulting in substitutions of MAB21L1 Arg51 Cause Aniridia and microphthalmia. Publication Status: Online-Only, [RefSeq, PubMed]; Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye, notochord, neural tube and other organ tissues, and for embryonic turning (PubMed:11857508, PubMed:12642482). It is unclear whether it displays nucleotidyltransferase activity in vivo (By similarity). Binds single-stranded RNA (ssRNA) (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Required in developing embryos for embryonic turning, formation of the notochord, neural tube, and other organ tissues, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0008283 cell population proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0001654 eye development;GO:0043010 camera-type eye development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O70299-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25911-1", "uniprot_id": "LYN_MOUSE", "mass": 58812.0, "length": 512, "protein_name": "Tyrosine-protein kinase Lyn", "gene_name": "Lyn", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase Lyn isoform A", "refseq_ac": "NP_001104566", "gene_names_uniprotkb": "Lyn", "gene_names_refseq": "Hck-2; Lyn; p53Lyn; p56Lyn", "protein_names_uniprotkb": "Tyrosine-protein kinase Lyn; 2.7.10.2; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn", "protein_names_refseq": "V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Yamaguchi sarcoma viral (v-yes-1) oncogene homolog; tyrosine-protein kinase Lyn isoform A; tyrosine-protein kinase Lyn", "tax_id": 10090, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); intestinal cancer (Disease Ontology:DOID:10155); endometriosis (Disease Ontology:DOID:289); Goldenhar syndrome (Disease Ontology:DOID:2907); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:17096); (R-MMU-114604); (R-MMU-1433557); (R-MMU-1433559); (R-MMU-2029481); (R-MMU-210990); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-389356); (R-MMU-389513); (R-MMU-3928662); (R-MMU-3928663); (R-MMU-3928665); (R-MMU-5621480); (R-MMU-5621575); (R-MMU-5690714); (R-MMU-69231); (R-MMU-75892); (R-MMU-9006335); (R-MMU-9027276); (R-MMU-9027284); (R-MMU-912631); (R-MMU-9674555); (R-MMU-9705462); (R-MMU-982772)", "pathway_count": 28, "publication_count": 78, "publication_id_list": "10327049;10415030;10594694;10640270;10672044;11007759;11435302;11517336;11672542;12077122;12486102;12681493;12874221;14525964;14726379;15220000;15304502;15335855;15489917;15504915;15664155;16034130;16116174;16249387;16272347;16684964;16731527;1702903;1710766;17233630;17640867;18034455;18984583;19064729;19144319;19290919;19492092;2017160;20189992;20385881;20644716;21183079;22496641;24440445;2482828;25428506;26495903;26740625;28011936;28098138;29187734;30084848;30116247;30779550;31219806;34428180;36210013;37507081;39007135;7513017;7584145;7585947;7782294;8128248;8168489;8183901;8530369;8621063;8629002;9036984;9064343;9252121;9469421;9480991;9547345;9573010;9590210;9601638", "class_list": "", "function": "Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Involved in the regulation of endothelial activation, neutrophil adhesion and transendothelial migration (By similarity). Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, MS4A2/FCER1B, SYK and TEC. Phosphorylates PIRB at Tyr-794 and Tyr-824, which is required for PIRB interaction with PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10327049). Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-96'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (PubMed:28098138). Phosphorylates CLNK (PubMed:12681493). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The dualistic role of Lyn tyrosine kinase in immune cell signaling: implications for systemic lupus erythematosus. Review article Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62127", "ec_number_list": "2.7.12.2;2.7.10.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.1;3.6.5.2;2.3.2.27;2.7.11.13;3.1.3.48;2.7.11.22;2.7.10.4;2.7.1.40;2.3.2.24;2.3.2.23;3.1.3.16;2.7.11.24;2.7.11.23;3.1.4.11;3.1.3.86;3.1.3.56;3.1.3.36;2.7.1.154;2.3.2.32", "go_molecular_function": "GO:0043208 glycosphingolipid binding;GO:0005161 platelet-derived growth factor receptor binding;GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:1902532 negative regulation of intracellular signal transduction;GO:0060252 positive regulation of glial cell proliferation;GO:0002431 Fc receptor mediated stimulatory signaling pathway;GO:0002513 tolerance induction to self antigen", "synthesized_glycan_count": 0, "hit_score": 8.1, "record_id": "P25911-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97412-1", "uniprot_id": "LYST_MOUSE", "mass": 425287.0, "length": 3788, "protein_name": "Lysosomal-trafficking regulator", "gene_name": "Lyst", "organism": "Mouse", "refseq_name": "lysosomal-trafficking regulator", "refseq_ac": "NP_034878", "gene_names_uniprotkb": "Lyst; Bg; Chs1", "gene_names_refseq": "D13Sfk13; Lyst; beige; bg", "protein_names_uniprotkb": "Lysosomal-trafficking regulator; Beige protein; CHS1 homolog", "protein_names_refseq": "CHS1 homolog; lysosomal-trafficking regulator", "tax_id": 10090, "disease": "exfoliation syndrome (Disease Ontology:DOID:13641); platelet storage pool deficiency (Disease Ontology:DOID:2223); Chediak-Higashi syndrome (Disease Ontology:DOID:2935)", "pathway": " (mmu:17101)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;16452087;17242355;20173027;20484733;21183079;21750661;25428506;25605945;27881733;30084848;30779550;31219806;34428180;8673129;8717042;9215680", "class_list": "", "function": "Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (By similarity). Might regulate trafficking of effectors involved in exocytosis (By similarity). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (By similarity). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (PubMed:27881733). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733)., [UniProtKB, PubMed, UniProtKB]; Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes. Might regulate trafficking of effectors involved in exocytosis. In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules. In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes. In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q62403;Q8VBS6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005764 lysosome;GO:0015630 microtubule cytoskeleton;GO:0005737 cytoplasm", "go_biological_process": "GO:0051607 defense response to virus;GO:0002446 neutrophil mediated immunity;GO:0006909 phagocytosis;GO:0007596 blood coagulation;GO:0055091 phospholipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P97412-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BML1-4", "uniprot_id": "MICA2_MOUSE", "mass": 218042.0, "length": 1951, "protein_name": "[F-actin]-monooxygenase MICAL2", "gene_name": "Mical2", "organism": "Mouse", "refseq_name": "[F-actin]-monooxygenase MICAL2 isoform A", "refseq_ac": "NP_001180234", "gene_names_uniprotkb": "Mical2; Kiaa0750; Micalcl", "gene_names_refseq": "4921517J23Rik; 5330438E18Rik; 9530064J02; MICAL-2; Mical2; Micalcl; mKIAA0750", "protein_names_uniprotkb": "[F-actin]-monooxygenase MICAL2; 1.14.13.225; ERK2-binding testicular protein 1; MICAL C-terminal-like protein; MICAL-2; Mical-cL; Molecule interacting with CasL protein 2; mMical2", "protein_names_refseq": "ERK2-binding testicular protein 1; MICAL C-terminal like; MICAL C-terminal-like protein-like; [F-actin]-methionine sulfoxide oxidase MICAL2; [F-actin]-monooxygenase MICAL2 isoform A; [F-actin]-monooxygenase MICAL2; ebitein-1; ebitein1; mMical2; mical-cL; microtubule associated monoxygenase, calponin and LIM domain containing 2; molecule interacting with CasL protein 2; protein MICAL-2; protein-methionine sulfoxide oxidase MICAL2", "tax_id": 10090, "disease": "", "pathway": " (mmu:320878)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12110185;18241670;18590835;18700133;21183079;23911929;23927065;25428506;30084848;30779550;31599954;32811811;33453238", "class_list": "", "function": "Based on empirical and bioinformatic analyses, we propose two domains in EBITEIN1. One is the minimal sequence for binding ERK2 (EB domain) and the other is the EBITEIN1 C-terminal domain (ECT domain)., [RefSeq, PubMed]; EBITEIN1 is a phosphoprotein and a downstream interactor of ERK2 that participates in the intracellular signal transduction pathway mediating the morphogenetic development of round spermatids into spermatozoa., [RefSeq, PubMed]; MICAL2 is essential for myogenic lineage commitment. Publication Status: Online-Only, [RefSeq, PubMed]; MICAL2 regulates myofibroblasts differentiation in epidural fibrosis via SRF/MRTF-A signaling pathway., [RefSeq, PubMed]; Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:23911929, PubMed:23927065). Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B1B545;F6ZD54;F8WJF1;Q14DP1;Q3TR48;Q3UPU6;Q5DU17;Q8CID1;Q9D5U9", "ec_number_list": "1.14.13.225;1.6.3.1", "go_molecular_function": "GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0071949 FAD binding;GO:0051019 mitogen-activated protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005884 actin filament", "go_biological_process": "GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BML1-4", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBT9-1", "uniprot_id": "M2GD_MOUSE", "mass": 97255.0, "length": 869, "protein_name": "Dimethylglycine dehydrogenase, mitochondrial", "gene_name": "Dmgdh", "organism": "Mouse", "refseq_name": "dimethylglycine dehydrogenase, mitochondrial precursor", "refseq_ac": "NP_083048", "gene_names_uniprotkb": "Dmgdh", "gene_names_refseq": "1200014D15Rik; Dmgdh", "protein_names_uniprotkb": "Dimethylglycine dehydrogenase, mitochondrial; 1.5.8.4; ME2GLYDH", "protein_names_refseq": "ME2GLYDH; dimethylglycine dehydrogenase, mitochondrial precursor; dimethylglycine dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "dimethylglycine dehydrogenase deficiency (Disease Ontology:DOID:0081446); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:74129); (R-MMU-6798163)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "18782777;23576753;23806337;34428180;37453647", "class_list": "", "function": "ARC may protect cardiomyocytes from hypoxic cell death by regulating its downstream, Drbp1 and pMe(2)GlyDH, [RefSeq, PubMed]; Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro., [UniProtKB, UniProtKB]; This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. [provided by RefSeq, Jul 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1B1D0;Q8R1S7", "ec_number_list": "1.5.8.4", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0005542 folic acid binding;GO:0047865 dimethylglycine dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0042426 choline catabolic process;GO:0035999 tetrahydrofolate interconversion;GO:0006579 amino-acid betaine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DBT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70310-1", "uniprot_id": "NMT1_MOUSE", "mass": 56888.0, "length": 496, "protein_name": "Glycylpeptide N-tetradecanoyltransferase 1", "gene_name": "Nmt1", "organism": "Mouse", "refseq_name": "glycylpeptide N-tetradecanoyltransferase 1", "refseq_ac": "NP_032733", "gene_names_uniprotkb": "Nmt1", "gene_names_refseq": "Nmt1", "protein_names_uniprotkb": "Glycylpeptide N-tetradecanoyltransferase 1; 2.3.1.97; Myristoyl-CoA:protein N-myristoyltransferase 1; NMT 1; Peptide N-myristoyltransferase 1; Type I N-myristoyltransferase", "protein_names_refseq": "NMT 1; glycylpeptide N-tetradecanoyltransferase 1; myristoyl-CoA:protein N-myristoyltransferase 1; peptide N-myristoyltransferase 1; type I N-myristoyltransferase", "tax_id": 10090, "disease": "muscular disease (Disease Ontology:DOID:0080000)", "pathway": " (mmu:18107); (R-MMU-2514859); (R-MMU-75108)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "15753093;16123142;17242355;18178842;20173027;21183079;22645316;25153642;25428506;25605945;28135057;28528544;30084848;30779550;32848054;34428180;35732157;35984892;36288343;37453647;9506952", "class_list": "", "function": "Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:15753093). Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (By similarity). Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (By similarity). Required for normal embryogenesis (PubMed:15753093)., [UniProtKB, UniProtKB, PubMed]; NMT1 Enhances the Stemness of NSCLC Cells by Activating the PI3K/AKT Pathway. Erratum:[Pharmacology. 2023;108(3):308. doi: 10.1159/000529046. PMID: 37497983], [RefSeq, PubMed]; NMT1 and NMT2 have only partially overlapping functions; NMT1 is critical for tumor cell proliferation, [RefSeq, PubMed]; NMT1 is essential for proper monocytic differentiation of the mouse bone marrow cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.97;3.6.5.-", "go_molecular_function": "GO:0004379 glycylpeptide N-tetradecanoyltransferase activity;GO:0019107 myristoyltransferase activity;GO:0018030 peptidyl-lysine N6-myristoyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0042180 ketone metabolic process;GO:0018008 N-terminal peptidyl-glycine N-myristoylation;GO:0001701 in utero embryonic development;GO:0031669 cellular response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "O70310-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61941-1", "uniprot_id": "NNTM_MOUSE", "mass": 113838.0, "length": 1086, "protein_name": "NAD(P) transhydrogenase, mitochondrial", "gene_name": "Nnt", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nnt", "gene_names_refseq": "", "protein_names_uniprotkb": "NAD(P) transhydrogenase, mitochondrial; 7.1.1.1; Nicotinamide nucleotide transhydrogenase; Pyridine nucleotide transhydrogenase", "protein_names_refseq": "", "tax_id": 10090, "disease": "familial glucocorticoid deficiency (Disease Ontology:DOID:0080620); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-MMU-71403)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11513952;21750661;22634753;23806337;30084848;31219806;34428180;36288343;37453647;37828378;39927985;8616157", "class_list": "", "function": "The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JK70", "ec_number_list": "7.1.1.1", "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0050661 NADP binding;GO:0008750 proton-translocating NAD(P)+ transhydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:1903285 positive regulation of hydrogen peroxide catabolic process;GO:0043066 negative regulation of apoptotic process;GO:0001933 negative regulation of protein phosphorylation;GO:0045454 cell redox homeostasis;GO:0072593 reactive oxygen species metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q61941-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG60-1", "uniprot_id": "TXNIP_MOUSE", "mass": 44363.0, "length": 397, "protein_name": "Thioredoxin-interacting protein", "gene_name": "Txnip", "organism": "Mouse", "refseq_name": "thioredoxin-interacting protein isoform 1", "refseq_ac": "NP_001009935", "gene_names_uniprotkb": "Txnip; Vdup1", "gene_names_refseq": "1200008J08Rik; Hyplip1; THIF; Tbp-2; Txnip; VDUP1", "protein_names_uniprotkb": "Thioredoxin-interacting protein; Vitamin D3 up-regulated protein 1", "protein_names_refseq": "hyperlipidemia 1; thioredoxin binding protein-2; thioredoxin-interacting protein isoform 1; upregulated by 1,25-dihydroxyvitamin D-3; vitamin D3 up-regulated protein 1", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); Reye syndrome (Disease Ontology:DOID:14525); glaucoma (Disease Ontology:DOID:1686); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:56338); (R-MMU-844456)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10843682;11376942;15723808;15930262;31164864;31219806;34428180;36210013;38892474", "class_list": "", "function": "May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:10843682). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (PubMed:15930262). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (By similarity). Required for the maturation of natural killer cells (PubMed:15723808). Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGQ0;Q8K2B2;Q9DC00;Q9EP90;Q9R115", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004857 enzyme inhibitor activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071228 cellular response to tumor cell;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006979 response to oxidative stress;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BG60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64163-1", "uniprot_id": "TFDP2_MOUSE", "mass": 49098.0, "length": 446, "protein_name": "Transcription factor Dp-2", "gene_name": "Tfdp2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tfdp2; Dp2", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor Dp-2; Dp-3; E2F dimerization partner 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-1538133); (R-MMU-2173796); (R-MMU-69231); (R-MMU-8953750)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "21750661;22872234;25428506;34428180;36210013;7478568;8923205;9878064", "class_list": "", "function": "Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q64163-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZS3-1", "uniprot_id": "NUMB_MOUSE", "mass": 70813.0, "length": 653, "protein_name": "Protein numb homolog", "gene_name": "Numb", "organism": "Mouse", "refseq_name": "protein numb homolog isoform 1", "refseq_ac": "NP_001129547", "gene_names_uniprotkb": "Numb", "gene_names_refseq": "Nb; Numb", "protein_names_uniprotkb": "Protein numb homolog; m-Nb; m-Numb", "protein_names_refseq": "numb gene homolog; protein numb homolog isoform 1; protein numb homolog", "tax_id": 10090, "disease": "brain cancer (Disease Ontology:DOID:1319)", "pathway": " (mmu:18222); (R-MMU-437239); (R-MMU-5610780); (R-MMU-5632684)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "10551880;10841580;11782429;12410312;14641329;15273690;17174898;17242355;19144319;21183079;21750661;31219806;31433979;31599954;34428180;37828378;8755477;9535908", "class_list": "", "function": "MNumb splicing isoform has an inhibitory effect on Notch signaling, indicating its potential roles in the differentiation of pancreatic endocrine lineage., [RefSeq, PubMed]; Regulates clathrin-mediated receptor endocytosis (By similarity). Plays a role in the process of neurogenesis (PubMed:10841580, PubMed:12410312, PubMed:15273690, PubMed:17174898). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (PubMed:12410312, PubMed:15273690). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis (PubMed:12410312, PubMed:15273690). Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (PubMed:17174898). May also mediate local repair of brain ventricular wall damage (PubMed:17174898)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a conserved protein that is distributed asymmetrically during cell division in the developing embryo. The encoded protein participates in cell fate decisions by interacting with the Notch receptor. Loss of function of this gene results in severe defects in neural development and loss of viability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P70422;Q8CIB1;Q9DC57;Q9QZR1;Q9QZS4", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding;GO:0045294 alpha-catenin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0007409 axonogenesis;GO:0030335 positive regulation of cell migration;GO:0030900 forebrain development;GO:0045664 regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9QZS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89016-1", "uniprot_id": "ABCD4_MOUSE", "mass": 68583.0, "length": 606, "protein_name": "Lysosomal cobalamin transporter ABCD4", "gene_name": "Abcd4", "organism": "Mouse", "refseq_name": "lysosomal cobalamin transporter ABCD4", "refseq_ac": "NP_033018", "gene_names_uniprotkb": "Abcd4; Pxmp1l", "gene_names_refseq": "Abcd4; P69r; P70R; Pxmp1l", "protein_names_uniprotkb": "Lysosomal cobalamin transporter ABCD4; 7.6.2.8; ATP-binding cassette sub-family D member 4; P70R; PMP69; PMP70-related protein; PXMP1-L; Peroxisomal membrane protein 1-like; Peroxisomal membrane protein 69", "protein_names_refseq": "ATP-binding cassette, sub-family D (ALD), member 4; PMP69; PMP70-related protein; PXMP1-L; lysosomal cobalamin transporter ABCD4; peroxisomal membrane protein 69; peroxisomal membrane protein, 70 kDa-related", "tax_id": 10090, "disease": "vitamin B12 deficiency (Disease Ontology:DOID:0050731)", "pathway": " (mmu:19300); (R-MMU-9758881); (R-MMU-9758890)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "19010322;21750661;34428180;38764031;9738957", "class_list": "", "function": "ABCD4 is associated with mammary gland development in mammals. Publication Status: Online-Only, [RefSeq, PubMed]; Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner. Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane. Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; P70R resides in the ER but not the peroxisomal membranes, and the hydrophobic property of NH(2)-terminal region determines the subcellular localization of ABC subfamily D proteins., [RefSeq, PubMed]; The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that the human protein may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QKU3", "ec_number_list": "7.6.2.8", "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0042760 very long-chain fatty acid catabolic process;GO:0007031 peroxisome organization;GO:0015910 long-chain fatty acid import into peroxisome;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O89016-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C138-1", "uniprot_id": "ADTRP_MOUSE", "mass": 27003.0, "length": 230, "protein_name": "Androgen-dependent TFPI-regulating protein", "gene_name": "Adtrp", "organism": "Mouse", "refseq_name": "androgen-dependent TFPI-regulating protein isoform 2", "refseq_ac": "NP_001139347", "gene_names_uniprotkb": "Adtrp; 9530008L14Rik", "gene_names_refseq": "9530008L14Rik; Adtrp", "protein_names_uniprotkb": "Androgen-dependent TFPI-regulating protein; 3.1.-.-; FAHFA hydrolase ADTRP; Fatty acid esters of hydroxy fatty acids hydrolase ADTRP", "protein_names_refseq": "FAHFA hydrolase ADTRP; androgen-dependent TFPI-regulating protein isoform 2; androgen-dependent TPF1-regulating protein; fatty acid esters of hydroxy fatty acids hydrolase ADTRP", "tax_id": 10090, "disease": "", "pathway": " (mmu:109254)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;30571485;32152231;34288722;34428180;35804197", "class_list": "", "function": "AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice., [RefSeq, PubMed]; Adtrp regulates thermogenic activity of adipose tissue via mediating the secretion of S100b. Publication Status: Online-Only, [RefSeq, PubMed]; Hepatic ADTRP overexpression does not influence lipid and glucose metabolism., [RefSeq, PubMed]; Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (By similarity). Shows a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (By similarity). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (By similarity)., [UniProtKB, UniProtKB]; Role in vascular development and function, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Z6U0;Q3UXS3;Q8K180", "ec_number_list": "3.1.1.13;3.1.1.3;3.1.1.6;3.1.-.-", "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane;GO:0012505 endomembrane system;GO:0005901 caveola", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0010628 positive regulation of gene expression;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0002686 negative regulation of leukocyte migration;GO:0042758 long-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C138-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U827-1", "uniprot_id": "RN180_MOUSE", "mass": 67371.0, "length": 592, "protein_name": "E3 ubiquitin-protein ligase RNF180", "gene_name": "Rnf180", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF180 isoform 1", "refseq_ac": "NP_082210", "gene_names_uniprotkb": "Rnf180; Rines", "gene_names_refseq": "3110001E11Rik; Rines; Rnf180", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF180; 2.3.2.27; RING finger protein 180; RING-type E3 ubiquitin transferase RNF180", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF180 isoform 1; E3 ubiquitin-protein ligase RNF180; RING-type E3 ubiquitin transferase RNF180", "tax_id": 10090, "disease": "", "pathway": " (mmu:71816)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18363970;21183079;21750661;23926250;37095741;39060657", "class_list": "", "function": "E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to promote colon inflammation and Th17/Treg imbalance in ulcerative colitis mice., [RefSeq, PubMed]; E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2., [UniProtKB, PubMed]; RING finger gene 180 inhibits osteosarcoma progression through regulating chromobox homolog 4 ubiquitination., [RefSeq, PubMed]; Rines is a critical regulator of the monoaminergic system and emotional behavior and identify a promising candidate drug target for treating diseases associated with emotion., [RefSeq, PubMed]; The involvement of RNF180 in the ubiquitin-proteasome pathway was further supported by its binding to the UbcH6 ubiquitin-conjugating enzyme and by its trans-ubiquitination enhancing activities., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UW39;Q80ZX1;Q8CCR1;Q9CXV6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030534 adult behavior;GO:0050790 regulation of catalytic activity;GO:0031398 positive regulation of protein ubiquitination;GO:0042428 serotonin metabolic process;GO:0042415 norepinephrine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3U827-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWU0-1", "uniprot_id": "TDR12_MOUSE", "mass": 137627.0, "length": 1215, "protein_name": "Putative ATP-dependent RNA helicase TDRD12", "gene_name": "Tdrd12", "organism": "Mouse", "refseq_name": "putative ATP-dependent RNA helicase TDRD12 isoform 1", "refseq_ac": "NP_082310", "gene_names_uniprotkb": "Tdrd12; Ecat8; Repro23", "gene_names_refseq": "2410004F06Rik; 2410070K17Rik; ECAT8; EG434165; G1-476-14; Tdrd12; repro23", "protein_names_uniprotkb": "Putative ATP-dependent RNA helicase TDRD12; 3.6.4.13; ES cell-associated transcript 8 protein; Tudor domain-containing protein 12", "protein_names_refseq": "ES cell associated transcript 8; ES cell-associated transcript 8 protein; putative ATP-dependent RNA helicase TDRD12 isoform 1; putative ATP-dependent RNA helicase TDRD12; tudor domain-containing protein 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:71981)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12787504;20173027;21750661;24067652;26669262;31219806;35820727", "class_list": "", "function": "Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:24067652). Involved in the secondary piRNAs metabolic process (PubMed:24067652). Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs (PubMed:26669262)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;2.1.1.386;3.1.26.-;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003676 nucleic acid binding;GO:0003724 RNA helicase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005829 cytosol;GO:1990923 PET complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0009566 fertilization;GO:0007140 male meiotic nuclear division;GO:0034587 piRNA processing;GO:0042078 germ-line stem cell division", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CWU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88700-1", "uniprot_id": "BLM_MOUSE", "mass": 158366.0, "length": 1416, "protein_name": "RecQ-like DNA helicase BLM", "gene_name": "Blm", "organism": "Mouse", "refseq_name": "recQ-like DNA helicase BLM isoform 2", "refseq_ac": "NP_001035992", "gene_names_uniprotkb": "Blm", "gene_names_refseq": "Blm", "protein_names_uniprotkb": "RecQ-like DNA helicase BLM; 5.6.2.4; Bloom syndrome protein homolog; DNA 3'-5' helicase BLM; RecQ helicase homolog; mBLM", "protein_names_refseq": "Bloom syndrome homolog; Bloom syndrome, RecQ helicase-like; DNA 3'-5' helicase BLM; bloom syndrome protein homolog; mBLM; recQ helicase homolog; recQ-like DNA helicase BLM isoform 2; recQ-like DNA helicase BLM", "tax_id": 10090, "disease": "Bloom syndrome (Disease Ontology:DOID:2717); Werner syndrome (Disease Ontology:DOID:5688)", "pathway": " (mmu:12144); (R-MMU-174414); (R-MMU-174437); (R-MMU-3108214); (R-MMU-5685938); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693568); (R-MMU-5693579); (R-MMU-5693607); (R-MMU-5693616); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 13, "publication_count": 13, "publication_id_list": "21183079;21750661;25428506;27010503;29125140;30084848;30779550;31219806;34428180;35820727;36163151;9655940;9840919", "class_list": "", "function": "ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:9840919). Participates in DNA replication and repair (By similarity). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:9840919). Negatively regulates sister chromatid exchange (SCE) (PubMed:27010503, PubMed:9840919). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution. Unwinds G-quadruplex DNA. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (By similarity). Recruited by the KHDC3-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Involvement of a BH3-only apoptosis sensitizer gene Blm-s in hippocampus-mediated mood control. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88198", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;2.7.11.1;7.6.2.1;3.6.1.5;5.6.2.1;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;2.7.11.22;6.5.1.1;3.6.4.6;2.7.7.7;3.1.11.-;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.49;2.3.1.48;2.3.1.-;2.7.4.3;3.1.22.-;3.1.11.2", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006281 DNA repair;GO:0051259 protein complex oligomerization;GO:0051260 protein homooligomerization;GO:0071466 cellular response to xenobiotic stimulus;GO:0000723 telomere maintenance", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O88700-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPL9-1", "uniprot_id": "ACOX3_MOUSE", "mass": 78404.0, "length": 700, "protein_name": "Peroxisomal acyl-coenzyme A oxidase 3", "gene_name": "Acox3", "organism": "Mouse", "refseq_name": "peroxisomal acyl-coenzyme A oxidase 3 isoform a", "refseq_ac": "NP_109646", "gene_names_uniprotkb": "Acox3", "gene_names_refseq": "Acox3; EST-s59; PCOX", "protein_names_uniprotkb": "Peroxisomal acyl-coenzyme A oxidase 3; 1.3.3.6; BRCACox; Branched-chain acyl-CoA oxidase; Pristanoyl-CoA oxidase", "protein_names_refseq": "BRCACox; branched-chain acyl-CoA oxidase; peroxisomal acyl-coenzyme A oxidase 3 isoform a; peroxisomal acyl-coenzyme A oxidase 3; pristanoyl-CoA oxidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:80911); (R-MMU-389887); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23806337;25605945;26740625;34428180", "class_list": "", "function": "Involved in peroxisomal beta-oxidation of branched-chain fatty acids (BCFAs). Catalyzes the initial and rate-limiting dehydrogenation step that removes two hydrogen molecules and introduces a trans double bond between the alpha and beta carbons of the acyl CoA molecules while generating hydrogen peroxide as a by-product (By similarity). Metabolizes multi-methyl-branched fatty acyl-CoA esters such as (2S)-pristanoyl-CoA, displaying redundancy with ACOX3 (By similarity). Can oxidize straight-chain mono- and dicarboxylyl fatty acyl-CoAs with lower efficiency (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Oxidizes the CoA-esters of 2-methyl-branched fatty acids., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPP6;Q80UQ0", "ec_number_list": "2.3.2.27;5.1.99.4;2.6.1.51;2.6.1.44;5.3.3.21;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.1.2.-;3.1.2.2;1.1.1.42;3.6.1.-;3.6.1.77;1.4.3.3;1.11.1.6;1.14.13.39;2.3.1.176;2.3.1.16;2.3.1.155;4.1.3.4;2.3.1.137;2.3.1.7;2.3.2.36;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;2.3.1.42;1.5.3.13;2.3.1.65;1.4.3.1;4.1.1.9;1.1.1.300;1.1.1.184;1.3.1.38;1.5.3.1;1.5.3.7;3.4.21.-;3.4.21.53;2.5.1.18;1.3.3.6;3.4.24.56;1.1.3.15;4.1.2.63;1.2.3.5;5.3.3.8;1.3.1.124", "go_molecular_function": "GO:0005504 fatty acid binding;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0016402 pristanoyl-CoA oxidase activity;GO:0120524 long-chain fatty acyl-CoA oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9EPL9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62717-1", "uniprot_id": "RL18A_MOUSE", "mass": 20732.0, "length": 176, "protein_name": "Large ribosomal subunit protein eL20", "gene_name": "Rpl18a", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL20", "refseq_ac": "NP_084027", "gene_names_uniprotkb": "Rpl18a", "gene_names_refseq": "2510019J09Rik; Rpl18a", "protein_names_uniprotkb": "Large ribosomal subunit protein eL20; 60S ribosomal protein L18a", "protein_names_refseq": "60S ribosomal protein L18a; large ribosomal subunit protein eL20", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:76808); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 10, "publication_id_list": "21183079;21750661;23806337;26740625;33300544;34428180;36517592;37453647;37507081;39627609", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P11249;Q3TSN0", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0045202 synapse;GO:0005840 ribosome", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P62717-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12660-1", "uniprot_id": "PCP2_MOUSE", "mass": 13054.0, "length": 120, "protein_name": "Purkinje cell protein 2", "gene_name": "Pcp2", "organism": "Mouse", "refseq_name": "Purkinje cell protein 2 isoform 2", "refseq_ac": "NP_001123276", "gene_names_uniprotkb": "Pcp2; Pcp-2", "gene_names_refseq": "L7; Pcp-2; Pcp2", "protein_names_uniprotkb": "Purkinje cell protein 2; Protein PCD-5; Purkinje cell-specific protein L7", "protein_names_refseq": "Purkinje cell protein 2 isoform 2; Purkinje cell-specific protein L7; protein PCD-5; retinal Purkinje cell protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:18545); (R-MMU-418594)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "2065970;21183079;21750661;2483097;3199205", "class_list": "", "function": "May function as a cell-type specific modulator for G protein-mediated cell signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P22941;Q3TV53", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "", "go_biological_process": "GO:0016056 G protein-coupled opsin signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P12660-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34056-1", "uniprot_id": "AP2A_MOUSE", "mass": 47971.0, "length": 437, "protein_name": "Transcription factor AP-2-alpha", "gene_name": "Tfap2a", "organism": "Mouse", "refseq_name": "transcription factor AP-2-alpha isoform 1", "refseq_ac": "NP_001288603", "gene_names_uniprotkb": "Tfap2a; Ap2tf; Tcfap2a", "gene_names_refseq": "AP-2; AP2alpha; Ap-2 (a); Ap2tf; Ap2; Tcfap2a; Tfap2a", "protein_names_uniprotkb": "Transcription factor AP-2-alpha; AP-2 transcription factor; AP-2; AP2-alpha; Activating enhancer-binding protein 2-alpha; Activator protein 2", "protein_names_refseq": "activating enhancer-binding protein 2 alpha; activator protein 2; transcription factor AP-2-alpha isoform 1", "tax_id": 10090, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); branchiooculofacial syndrome (Disease Ontology:DOID:0050691); dilated cardiomyopathy (Disease Ontology:DOID:12930); sleep disorder (Disease Ontology:DOID:535)", "pathway": " (mmu:21418); (R-MMU-8864260); (R-MMU-8866904); (R-MMU-8866907); (R-MMU-8869496); (R-MMU-9834899)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "11688971;12504852;14572467;15475956;1989904;21750661;3063603;7750631;8233835", "class_list": "", "function": "A conserved N-terminus is observed for alpha, beta, gamma, and epsilon members of this gene family., [RefSeq, PubMed]; Downregulation of repressive isoforms during adipocyte differentiation, [RefSeq, PubMed]; N-terminal peptide sequencing indicates use of a downstream start codon in the human ortholog of AP-2., [RefSeq, PubMed]; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18 and C/EBP alpha. Is involved in the negative regulation of Wnt canonical signaling, and is a transcriptional repressor of MYC (By similarity). AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region., [UniProtKB, UniProtKB, PubMed]; This gene is a member of the activator protein 2 (AP-2) transcription factor family. The protein encoded by this gene can act as both an activator and repressor of gene transcription, and plays an important role in early embryogenesis, specifically in cranial development. This protein forms both homodimers and heterodimers, and binds to a GC-rich consensus sequence found in some promoters and enhancers. Disruption of this gene causes perinatal death, with neural tube, craniofacial, and limb mesenchyme defects. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Sep 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60740;Q60741;Q60742;Q60743;Q62067;Q62068;Q62069;Q91VX0;Q9CRY4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005905 clathrin-coated pit;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0010172 embryonic body morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P34056-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8C3-1", "uniprot_id": "ALG13_MOUSE", "mass": 128664.0, "length": 1166, "protein_name": "UDP-N-acetylglucosamine transferase subunit ALG13", "gene_name": "Alg13", "organism": "Mouse", "refseq_name": "UDP-N-acetylglucosamine transferase subunit ALG13", "refseq_ac": "NP_080523", "gene_names_uniprotkb": "Alg13", "gene_names_refseq": "2810046O15Rik; 4833435D08Rik; Alg13; Glt28d1; MDS031", "protein_names_uniprotkb": "UDP-N-acetylglucosamine transferase subunit ALG13; 2.4.1.141; Asparagine-linked glycosylation 13 homolog", "protein_names_refseq": "UDP-N-acetylglucosamine transferase subunit ALG13 homolog; UDP-N-acetylglucosamine transferase subunit ALG13; asparagine-linked glycosylation 13 homolog; glycosyltransferase 28 domain containing 1; glycosyltransferase 28 domain-containing protein 1; putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 36 (Disease Ontology:DOID:0080470)", "pathway": " (mmu:67574)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;30872163;35984892;36152356", "class_list": "glycogene;glycosyltransferase", "function": "Catalytic subunit of the UDP-N-acetylglucosamine transferase complex that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. On the cytoplasmic face of the endoplasmic reticulum, the dimeric ALG13/ALG14 complex catalyzes the second step of dolichol pyrophosphate biosynthesis, transferring a beta1,4-linked N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to GlcNAc-pyrophosphatedolichol (Gn-PDol) to produce N,N'-diacetylchitobiosyl diphosphodolichol. N,N'-diacetylchitobiosyl diphosphodolichol is a substrate for ALG1, the following enzyme in the biosynthetic pathway., [UniProtKB, UniProtKB]; Decreased cognitive function of ALG13KO female mice may be related to the decreased plasticity of hippocampal neurons., [RefSeq, PubMed]; Expression of ALG13 in the central nervous system (CNS) had histologically and cellular specificity, mainly in the neurons in the cortex and hippocampus. KA-induced seizures significantly affected the expression levels of ALG13 mRNA and protein in the forebrain of wild-type (WT) mice. KA-induced epileptic progressions were dramatically increased in Alg13 knockout (KO) mice., [RefSeq, PubMed]; No glycosyltransferase or deubiquitinase activity is detected for this potential multifunctional enzyme., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A3KGC8;A3KGD0;A3KGD1;Q8BUA4;Q9D5Z6", "ec_number_list": "2.4.1.141;3.4.19.12", "go_molecular_function": "GO:0004577 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity;GO:0008234 cysteine-type peptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005737 cytoplasm;GO:0043541 UDP-N-acetylglucosamine transferase complex;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006508 proteolysis;GO:0048167 regulation of synaptic plasticity;GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation;GO:1904262 negative regulation of TORC1 signaling", "synthesized_glycan_count": 15150, "hit_score": 0.5, "record_id": "Q9D8C3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBA9-1", "uniprot_id": "TF2H1_MOUSE", "mass": 61851.0, "length": 547, "protein_name": "General transcription factor IIH subunit 1", "gene_name": "Gtf2h1", "organism": "Mouse", "refseq_name": "general transcription factor IIH subunit 1 isoform 1", "refseq_ac": "NP_001278004", "gene_names_uniprotkb": "Gtf2h1", "gene_names_refseq": "62kDa; BTF2 p62; Gtf2h1; p62", "protein_names_uniprotkb": "General transcription factor IIH subunit 1; BTF2 p62; Basic transcription factor 2 62 kDa subunit; General transcription factor IIH polypeptide 1; TFIIH basal transcription factor complex p62 subunit", "protein_names_refseq": "BTF2-p62; TFIIH basal transcription factor complex p62 subunit; basic transcription factor 2 62 kDa subunit; general transcription factor IIH subunit 1 isoform 1; general transcription factor IIH subunit 1; general transcription factor IIH, polypeptide 1 (62kD subunit)", "tax_id": 10090, "disease": "", "pathway": " (mmu:14884); (R-MMU-112382); (R-MMU-113418); (R-MMU-5696395); (R-MMU-5696400); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-72086); (R-MMU-73762); (R-MMU-73772); (R-MMU-73776); (R-MMU-73779); (R-MMU-73863); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-77075)", "pathway_count": 20, "publication_count": 9, "publication_id_list": "21659648;21750661;23806337;23872361;24173291;34428180;35993019;37828378;9630526", "class_list": "", "function": "Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mice with a liver overexpression of insulin-like growth factor 2 (IGF2) mRNA-binding protein p62/IMP2-2/IGF2BP2-2 show elevated Ccl2 levels, which models all stages of non-alcoholic fatty liver disease., [RefSeq, PubMed]; P62 is up-regulated in mouse proteinopathic hearts and promotes aggresome formation and autophagy activation and protects cardiomyocytes against proteotoxic stress, [RefSeq, PubMed]; The Mechanism of TNF-alpha-Mediated Accumulation of Phosphorylated Tau Protein and Its Modulation by Propofol in Primary Mouse Hippocampal Neurons: Role of Mitophagy, NLRP3, and p62/Keap1/Nrf2 Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; We propose that autophagy is inhibited in the alphaB-R120G mutant lenses because of a defect in protein degradation after autophagosome formation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35637", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046966 nuclear thyroid hormone receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005675 transcription factor TFIIH holo complex;GO:0000439 transcription factor TFIIH core complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0006281 DNA repair;GO:1990830 cellular response to leukemia inhibitory factor;GO:0045893 positive regulation of DNA-templated transcription;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9DBA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922Q6-1", "uniprot_id": "ABHEA_MOUSE", "mass": 27839.0, "length": 247, "protein_name": "Protein ABHD14A", "gene_name": "Abhd14a", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Abhd14a; Dorz1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein ABHD14A; 3.-.-.-; Abhydrolase domain-containing protein 14A; Alpha/beta hydrolase domain-containing protein 14A; Down-regulated in Zic-1-mutant protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:68644)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;14667578;21750661;34428180", "class_list": "", "function": "Possible role in granule neuron development., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4S5", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q922Q6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TMS5-1", "uniprot_id": "ABCG2_MOUSE", "mass": 72978.0, "length": 657, "protein_name": "Broad substrate specificity ATP-binding cassette transporter ABCG2", "gene_name": "Abcg2", "organism": "Mouse", "refseq_name": "broad substrate specificity ATP-binding cassette transporter ABCG2", "refseq_ac": "NP_036050", "gene_names_uniprotkb": "Abcg2; Abcp; Bcrp1", "gene_names_refseq": "ABC15; ABCP; Abcg2; BCRP; Bcrp1; MXR1; MXR", "protein_names_uniprotkb": "Broad substrate specificity ATP-binding cassette transporter ABCG2; 7.6.2.2; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein 1 homolog; Urate exporter", "protein_names_refseq": "ATP-binding cassette sub-family G member 2; ATP-binding cassette, sub-family G (WHITE), member 2; breast cancer resistance protein 1 homolog; broad substrate specificity ATP-binding cassette transporter ABCG2; mitoxantrone resistance protein 1; urate exporter", "tax_id": 10090, "disease": "secondary hyperparathyroidism (Disease Ontology:DOID:12466); gout (Disease Ontology:DOID:13189); erythropoietic protoporphyria (Disease Ontology:DOID:13270); status epilepticus (Disease Ontology:DOID:1824); hyperuricemia (Disease Ontology:DOID:1920); breast carcinoma (Disease Ontology:DOID:3459); toxic encephalopathy (Disease Ontology:DOID:3602); renal cell carcinoma (Disease Ontology:DOID:4450); B-cell lymphoma (Disease Ontology:DOID:707); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute megakaryocytic leukemia (Disease Ontology:DOID:8761); acute myeloid leukemia (Disease Ontology:DOID:9119); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:26357); (R-MMU-1660661); (R-MMU-189451); (R-MMU-189483); (R-MMU-917937); (R-MMU-9753281); (R-MMU-9793528)", "pathway_count": 7, "publication_count": 21, "publication_id_list": "10485464;11036110;11533706;12429862;12477054;15044468;17145775;21750661;25428506;30042379;30084848;34428180;37828378;38084678;38181789;38493880;38981367;38984714;39116875;39337371;9850061", "class_list": "", "function": "ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis., [RefSeq, PubMed]; ABCG2 shields against epilepsy, relieves oxidative stress and apoptosis via inhibiting the ISGylation of STAT1 and mTOR., [RefSeq, PubMed]; Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells (PubMed:10485464, PubMed:12429862, PubMed:12477054, PubMed:17145775, PubMed:30042379). Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme (PubMed:12429862, PubMed:15044468). Also mediates the efflux of sphingosine-1-P from cells (By similarity). Acts as a urate exporter functioning in both renal and extrarenal urate excretion (By similarity). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (PubMed:30042379). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (By similarity). Mediates the secretion of the vitamins riboflavin and biotin into milk (PubMed:17145775). Involved in the excretion of the riboflavin-derived compound lumichrome into the intestinal lumen and in its secretion into milk (PubMed:39337371). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (PubMed:12429862). Plays an important role in the exclusion of xenobiotics from the brain (PubMed:10485464). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (PubMed:12477054). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (PubMed:12429862). May play a role in early stem cell self-renewal by blocking differentiation (Probable). In inflammatory macrophages, exports itaconate from the cytosol to the extracellular compartment and limits the activation of TFEB-dependent lysosome biogenesis involved in antibacterial innate immune response., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; GRP/GRPR signaling pathway aggravates hyperuricemia-induced renal inflammation and fibrosis via ABCG2-dependent mechanisms., [RefSeq, PubMed]; Nongenomic ERalpha-AMPK Signaling Regulates Sex-Dependent Bcrp Transport Activity at the Blood-Brain Barrier., [RefSeq, PubMed]; The ABCG2 protein in vitro transports the xenobiotic thiabendazole and increases the appearance of its residues in milk., [RefSeq, PubMed]; The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, the human protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. This protein likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9R004;Q9Z1T0", "ec_number_list": "7.6.2.2;7.6.2.-;7.6.2.3;7.6.2.5", "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005524 ATP binding;GO:0022857 transmembrane transporter activity;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0001708 cell fate specification;GO:0071559 response to transforming growth factor beta;GO:0061026 cardiac muscle tissue regeneration;GO:0097168 mesenchymal stem cell proliferation;GO:1904238 pericyte cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q7TMS5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TFD2-1", "uniprot_id": "PCAT1_MOUSE", "mass": 59744.0, "length": 534, "protein_name": "Lysophosphatidylcholine acyltransferase 1", "gene_name": "Lpcat1", "organism": "Mouse", "refseq_name": "lysophosphatidylcholine acyltransferase 1 isoform 1", "refseq_ac": "NP_663351", "gene_names_uniprotkb": "Lpcat1; Aytl2", "gene_names_refseq": "2900035H07Rik; Aytl2; LPCAT-1; LPCAT; Lpcat1; lysoPAFAT; mLPCAT1; rd11", "protein_names_uniprotkb": "Lysophosphatidylcholine acyltransferase 1; 1-acylglycerol-3-phosphate O-acyltransferase; 1-acylglycerophosphocholine O-acyltransferase; 1-alkenylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; 2.3.1.23; 2.3.1.25; 2.3.1.51; 2.3.1.67; Acetyl-CoA:lyso-PAF acetyltransferase; Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; Acyltransferase-like 2; LPC acyltransferase 1; LPCAT-1; Lyso-PAF acetyltransferase; LysoPAFAT; LysoPC acyltransferase 1; mLPCAT1", "protein_names_refseq": "1-acylglycerol-3-phosphate O-acyltransferase; 1-acylglycerophosphocholine O-acyltransferase; 1-alkenylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; LPC acyltransferase 1; acetyl-CoA:lyso-PAF acetyltransferase; acetyl-CoA:lyso-platelet-activating factor acetyltransferase; acyltransferase-like 2; lyso-PAF acetyltransferase; lysoPC acyltransferase 1; lysophosphatidylcholine acyltransferase 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:210992); (R-MMU-1482788); (R-MMU-1482925); (R-MMU-1483166); (R-MMU-1483191); (R-MMU-6798695)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "16704971;16864775;18156367;18285344;21750661;38602252;38671262", "class_list": "", "function": "Acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1) is predominantly expressed in the lung, in particular in alveolar type II cells., [RefSeq, PubMed]; Aytl2 gene is the phosphatidylcholine reacylating enzyme in RBCs; this represents the identification of a plasma membrane lysophospholipid acyltransferase and establishes the function of a LPCAT protein, [RefSeq, PubMed]; Exhibits both acyltransferase and acetyltransferase activities (PubMed:16704971, PubMed:18156367, PubMed:18285344). Activity is calcium-independent (PubMed:16704971, PubMed:18285344). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:16704971, PubMed:18156367, PubMed:18285344). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (PubMed:16704971, PubMed:18285344). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (PubMed:18285344). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (PubMed:16704971). Involved in the regulation of lipid droplet number and size (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]; LPCAT1-mediated membrane phospholipid remodelling promotes ferroptosis evasion and tumour growth., [RefSeq, PubMed]; Lysophospholipid acyltransferase-mediated formation of saturated glycerophospholipids maintained cell membrane integrity for hypoxic adaptation., [RefSeq, PubMed]; Results suggest that lysophosphatidylcholine acyltransferase (LPCAT) plays a critical role in regulating surfactant phospholipid biosynthesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 25, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAX4;Q6NXZ6;Q8BG23;Q8BUX7;Q99JU6", "ec_number_list": "1.11.1.27;3.1.1.4;2.3.1.23;2.3.1.51;2.4.1.-;2.4.1.275;2.4.1.22;2.4.1.38;2.4.1.90;3.6.5.2;3.4.23.-;3.2.1.20;7.6.2.1;2.3.1.15;2.3.1.67;2.3.1.25;2.3.1.-;7.6.2.-;2.3.1.121;2.3.1.n6;2.3.1.n7;3.4.16.2;3.1.3.5;3.1.3.2;3.1.3.48;3.2.1.25;2.5.1.18;3.1.1.3;2.3.1.22;2.3.1.62;3.5.1.92", "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0005509 calcium ion binding;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet;GO:0005886 plasma membrane", "go_biological_process": "GO:0043129 surfactant homeostasis;GO:0060041 retina development in camera-type eye;GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:0045732 positive regulation of protein catabolic process;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3TFD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKX6-1", "uniprot_id": "NUDT5_MOUSE", "mass": 23984.0, "length": 218, "protein_name": "ADP-sugar pyrophosphatase", "gene_name": "Nudt5", "organism": "Mouse", "refseq_name": "ADP-sugar pyrophosphatase isoform a", "refseq_ac": "NP_058614", "gene_names_uniprotkb": "Nudt5", "gene_names_refseq": "Nudt5", "protein_names_uniprotkb": "ADP-sugar pyrophosphatase; 2.7.7.96; 3.6.1.13; 3.6.1.58; 8-oxo-dGDP phosphatase; Nuclear ATP-synthesis protein NUDIX5; Nucleoside diphosphate-linked moiety X motif 5; Nudix motif 5", "protein_names_refseq": "8-oxo-dGDP phosphatase; ADP-sugar pyrophosphatase isoform a; ADP-sugar pyrophosphatase; nuclear ATP-synthesis protein NUDIX5; nucleoside diphosphate-linked moiety X motif 5; nudix (nucleoside diphosphate linked moiety X)-type motif 5; nudix motif 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:53893); (R-MMU-2393930)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10722730;19131326;21070968;21750661;34428180;37828378", "class_list": "", "function": "Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (By similarity). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10722730). Can also hydrolyze other nucleotide sugars with low activity (PubMed:10722730). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate (By similarity). Nuclear ATP synthesis takes place when dephosphorylated at Thr-44 (By similarity). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity). In vitro, it has decapping activity on 11-mer RNA capped with uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) by hydrolyzing the pyrophosphate bridge of the sugar cap (By similarity). Does not play a role in U8 snoRNA decapping (PubMed:21070968). Binds U8 snoRNA (PubMed:21070968)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ATT6;Q99KM4", "ec_number_list": "3.6.1.58;3.6.1.68;3.6.1.76;3.6.1.13;3.6.1.16;3.6.1.53;3.6.1.-;3.6.1.45;2.7.7.96", "go_molecular_function": "GO:0044715 8-oxo-dGDP phosphatase activity;GO:0019144 ADP-sugar diphosphatase activity;GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0019693 ribose phosphate metabolic process;GO:0006338 chromatin remodeling;GO:0006139 nucleobase-containing compound metabolic process;GO:1990966 ATP generation from poly-ADP-D-ribose;GO:0009191 ribonucleoside diphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JKX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99J45-1", "uniprot_id": "NRBP_MOUSE", "mass": 59866.0, "length": 535, "protein_name": "Nuclear receptor-binding protein", "gene_name": "Nrbp1", "organism": "Mouse", "refseq_name": "nuclear receptor-binding protein isoform 2", "refseq_ac": "NP_671734", "gene_names_uniprotkb": "Nrbp1; Madm; Nrbp", "gene_names_refseq": "B230344L17Rik; Nrbp1; Nrbp", "protein_names_uniprotkb": "Nuclear receptor-binding protein; HLS7-interacting protein kinase; MLF1 adapter molecule", "protein_names_refseq": "HLS7-interacting protein kinase; MLF1 adapter molecule; nuclear receptor-binding protein isoform 2; nuclear receptor-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:192292)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12176995;15345747;17242355;21183079;21750661;22510880;30059200;32782141;32848054;34678516;36790665;36852467;40021952;40885482", "class_list": "", "function": "Required for embryonic development (PubMed:22510880). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (PubMed:22510880). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (By similarity)., [UniProtKB, UniProtKB, PubMed]; The Circular RNA Circ_0085494 Regulates Prostate Cancer Progression Through NRBP1/miR-497-5p Axis., [RefSeq, PubMed]; Using a novel combination of RNAi screens in worms together with detailed follow-up experiments in mouse and human cells, it was shown that NRBP1 is a tumour suppressor that plays a critical role in intestinal cell homoeostasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BL77", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0030027 lamellipodium;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0030855 epithelial cell differentiation;GO:0035556 intracellular signal transduction;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0050673 epithelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q99J45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08919-1", "uniprot_id": "NUMBL_MOUSE", "mass": 64130.0, "length": 604, "protein_name": "Numb-like protein", "gene_name": "Numbl", "organism": "Mouse", "refseq_name": "numb-like protein isoform 2", "refseq_ac": "NP_035080", "gene_names_uniprotkb": "Numbl; Nbl", "gene_names_refseq": "Numbl; nbl", "protein_names_uniprotkb": "Numb-like protein", "protein_names_refseq": "numb-like protein isoform 2; numb-like protein", "tax_id": 10090, "disease": "brain cancer (Disease Ontology:DOID:1319)", "pathway": " (mmu:18223)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12410312;15273690;17114649;17174898;21183079;22517741;22645316;32848054;34678516;40885482;9169836", "class_list": "", "function": "Mouse numb and numblike play redundant but critical roles in maintaining neural progenitor cells during embryogenesis, by allowing their progenies to choose progenitor over neuronal fates, [RefSeq, PubMed]; Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q4QQQ2;Q6NVG8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm", "go_biological_process": "GO:0007399 nervous system development;GO:0007409 axonogenesis;GO:0030900 forebrain development;GO:0034332 adherens junction organization;GO:0050775 positive regulation of dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O08919-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VI88-1", "uniprot_id": "ODFP4_MOUSE", "mass": 33177.0, "length": 290, "protein_name": "Outer dense fiber protein 4", "gene_name": "Odf4", "organism": "Mouse", "refseq_name": "outer dense fiber protein 4", "refseq_ac": "NP_665689", "gene_names_uniprotkb": "Odf4; Oppo1", "gene_names_refseq": "Odf4; Oppo1", "protein_names_uniprotkb": "Outer dense fiber protein 4; Outer dense fiber of sperm tails protein 4; Testis-specific protein oppo 1", "protein_names_refseq": "outer dense fiber of sperm tails protein 4; outer dense fiber protein 4; testis-specific protein oppo 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:252868)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12079992;21183079;21750661;36804949", "class_list": "", "function": "Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton., [UniProtKB, PubMed]; Oppo 1 plays an important role in sperm tail structure and/or sperm movement, [RefSeq, PubMed]; The association of ODF4 with AK1 and AK2 in mice is essential for fertility through its contribution to flagellar shape. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P8Z7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0005886 plasma membrane;GO:0031514 motile cilium", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VI88-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99P30-1", "uniprot_id": "NUDT7_MOUSE", "mass": 26857.0, "length": 236, "protein_name": "Peroxisomal coenzyme A diphosphatase NUDT7", "gene_name": "Nudt7", "organism": "Mouse", "refseq_name": "peroxisomal coenzyme A diphosphatase NUDT7 isoform 4", "refseq_ac": "NP_001277110", "gene_names_uniprotkb": "Nudt7", "gene_names_refseq": "1300007B24Rik; 2210404C19Rik; Nudt7", "protein_names_uniprotkb": "Peroxisomal coenzyme A diphosphatase NUDT7; 3.6.1.-; 3.6.1.77; Nucleoside diphosphate-linked moiety X motif 7; Nudix motif 7", "protein_names_refseq": "coenzyme A diphosphatase; nucleoside diphosphate-linked moiety X motif 7; nudix (nucleoside diphosphate linked moiety X)-type motif 7; nudix motif 7; peroxisomal coenzyme A diphosphatase NUDT7 isoform 4; peroxisomal coenzyme A diphosphatase NUDT7", "tax_id": 10090, "disease": "", "pathway": " (mmu:67528); (R-MMU-9033241)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11415433;18799520;21070968;23806337;29378847;30084848;30846528;32432673;34428180;36436558;37453647;37507081;37908734", "class_list": "", "function": "Data suggest that NUDT7alpha function is tightly linked to peroxisomal CoASH/acyl-CoA homeostasis., [RefSeq, PubMed]; Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (PubMed:11415433, PubMed:18799520, PubMed:29378847). Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies (PubMed:11415433). Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs (PubMed:18799520). Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester (PubMed:18799520). May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand (PubMed:18799520). Does not play a role in U8 snoRNA decapping activity (PubMed:21070968). Binds U8 snoRNA (PubMed:21070968). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; NUDT7 regulates total hepatic CoA levels and the composition of the intestinal bile acid pool in male mice fed a Western diet., [RefSeq, PubMed]; The modulation of Nudt7 activity could contribute to the regulation of the peroxisomal CoA pool and peroxisomal lipid metabolism., [RefSeq, PubMed]; Upregulated FOXM1 stimulates chondrocyte senescence in Acot12[-/-]Nudt7[-/-] double knockout mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IS65;Q8BU08;Q8K260;Q9D0Q3;Q9DBI9", "ec_number_list": "2.3.2.27;3.6.1.62;3.6.1.64;5.1.99.4;2.6.1.51;2.6.1.44;5.3.3.21;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.1.2.-;3.1.2.2;1.1.1.42;3.6.1.-;3.6.1.77;1.4.3.3;1.11.1.6;1.14.13.39;2.3.1.176;2.3.1.16;2.3.1.155;4.1.3.4;2.3.1.137;2.3.1.7;2.3.2.36;3.6.1.17;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;2.3.1.42;3.6.1.9;3.6.1.68;3.6.1.76;1.5.3.13;2.3.1.65;1.4.3.1;4.1.1.9;1.1.1.300;1.1.1.184;1.3.1.38;1.5.3.1;1.5.3.7;3.4.21.-;3.4.21.53;2.5.1.18;1.3.3.6;3.4.24.56;1.1.3.15;4.1.2.63;1.2.3.5;5.3.3.8;1.3.1.124", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0030515 snoRNA binding;GO:0010945 coenzyme A diphosphatase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0050873 brown fat cell differentiation;GO:0036114 medium-chain fatty-acyl-CoA catabolic process;GO:2001294 malonyl-CoA catabolic process;GO:0009132 nucleoside diphosphate metabolic process;GO:0015938 coenzyme A catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q99P30-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPR8-1", "uniprot_id": "NSE3_MOUSE", "mass": 31460.0, "length": 279, "protein_name": "Non-structural maintenance of chromosomes element 3 homolog", "gene_name": "Nsmce3", "organism": "Mouse", "refseq_name": "non-structural maintenance of chromosomes element 3 homolog", "refseq_ac": "NP_075728", "gene_names_uniprotkb": "Nsmce3; Mageg1; Ndnl2", "gene_names_refseq": "5730494G16Rik; HCA4; Mageg1; Ndnl2; Nsmce3; mage-g1", "protein_names_uniprotkb": "Non-structural maintenance of chromosomes element 3 homolog; MAGE-G1 antigen; Necdin-like protein 2; Non-SMC element 3 homolog", "protein_names_refseq": "MAGE-G1 antigen; melanoma antigen, family G, 1; melanoma-associated antigen G1; necdin-like 2; necdin-like protein 2; non-SMC element 3 homolog; non-structural maintenance of chromosomes element 3 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66647); (R-MMU-3108214)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11782285;14593116;28374796;31219806;32848054;34428180", "class_list": "", "function": "Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (PubMed:14593116)., [UniProtKB, UniProtKB, PubMed]; Gene expression, imprinting, and chromosome mapping of NDNL2 [NDNL2], [RefSeq, PubMed]; MAGE-G1 interacted with fascin 1 or vimentin in P19 cells after a 6-day retinoic acid-induced neuronal differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; Necdin and MAGE-G1 target both E2F1 and p75 to regulate cell viability during brain development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q569V7;Q9D378", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000781 chromosome, telomeric region;GO:0030915 Smc5-Smc6 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006355 regulation of DNA-templated transcription;GO:0031398 positive regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CPR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR24-1", "uniprot_id": "NUDT8_MOUSE", "mass": 23253.0, "length": 210, "protein_name": "Mitochondrial coenzyme A diphosphatase NUDT8", "gene_name": "Nudt8", "organism": "Mouse", "refseq_name": "mitochondrial coenzyme A diphosphatase NUDT8", "refseq_ac": "NP_079805", "gene_names_uniprotkb": "Nudt8", "gene_names_refseq": "2310039H17Rik; Nudt8", "protein_names_uniprotkb": "Mitochondrial coenzyme A diphosphatase NUDT8; 3.6.1.-; 3.6.1.77; Nucleoside diphosphate-linked moiety X motif 8; Nudix motif 8", "protein_names_refseq": "mitochondrial coenzyme A diphosphatase NUDT8; nucleoside diphosphate-linked moiety X motif 8, mitochondrial; nudix (nucleoside diphosphate linked moiety X)-type motif 8; nudix motif 8; nudix-type motif 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:66387)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23806337;25428506;31004344;31219806;32432673", "class_list": "", "function": "Acyl-CoA diphosphatase that mediates the hydrolysis of a wide range of CoA and CoA esters yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products (PubMed:31004344). Hydrolyzes short- and medium-chain acyl-CoAs, exhibiting the highest activity toward free CoA, hexanoyl-CoA, and octanoyl-CoA and the lowest activity against acetyl-CoA (PubMed:31004344). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673)., [UniProtKB, PubMed, PubMed]; Nudt8 is a novel CoA-degrading enzyme that resides in the mitochondria. Nudt8 specifically hydrolyzes CoA species and has a distinctive preference for manganese ions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDQ2", "ec_number_list": "3.6.1.62;3.6.1.64;3.6.1.-;3.6.1.77;3.6.1.17;3.6.1.9;3.6.1.68;3.6.1.76", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0010945 coenzyme A diphosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0036114 medium-chain fatty-acyl-CoA catabolic process;GO:2001294 malonyl-CoA catabolic process;GO:0015938 coenzyme A catabolic process;GO:0046356 acetyl-CoA catabolic process;GO:0044580 butyryl-CoA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CR24-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQQ9-1", "uniprot_id": "OGA_MOUSE", "mass": 103162.0, "length": 916, "protein_name": "Protein O-GlcNAcase", "gene_name": "Oga", "organism": "Mouse", "refseq_name": "protein O-GlcNAcase isoform 1", "refseq_ac": "NP_076288", "gene_names_uniprotkb": "Oga; Hexc; Kiaa0679; Mgea5", "gene_names_refseq": "Hy5; Mgea5; Ncoat; Oga", "protein_names_uniprotkb": "Protein O-GlcNAcase; 3.2.1.169; Beta-N-acetylhexosaminidase; Beta-hexosaminidase; Bifunctional protein NCOAT; Meningioma-expressed antigen 5; N-acetyl-beta-D-glucosaminidase; N-acetyl-beta-glucosaminidase; OGA", "protein_names_refseq": "N-acetyl-beta-D-glucosaminidase; N-acetyl-beta-glucosaminidase; beta-N-acetylhexosaminidase; beta-hexosaminidase; bifunctional protein NCOAT; meningioma expressed antigen 5 (hyaluronidase); meningioma-expressed antigen 5; nuclear cytoplasmic O-GlcNAcase and acetyltransferase; protein O-GlcNAcase isoform 1; protein O-GlcNAcase", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:76055)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;11341771;15345747;16356930;16517082;17242355;20173027;20485683;21183079;21750661;23395175;24563466;25428506;30084848;31219806;34428180;37186669", "class_list": "glycogene;glycosylhydrolase", "function": "Cleaves GlcNAc but not GalNAc from O-glycosylated proteins (PubMed:16517082). Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1 (By similarity). Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:16517082). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (By similarity)., [UniProtKB, UniProtKB, PubMed]; Restoration of coronary microvascular function by OGA overexpression in a high-fat diet with low-dose streptozotocin-induced type 2 diabetic mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 48, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3ULY7;Q6ZQ71;Q8BK05;Q8BTT2;Q8CFX2;Q9CSJ4;Q9CUR7", "ec_number_list": "3.2.1.169", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004402 histone acetyltransferase activity;GO:0016231 beta-N-acetylglucosaminidase activity;GO:0102571 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity;GO:0015929 hexosaminidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0046060 dATP metabolic process;GO:0032024 positive regulation of insulin secretion;GO:0043065 positive regulation of apoptotic process;GO:0006612 protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9EQQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R061-1", "uniprot_id": "NUBP2_MOUSE", "mass": 29518.0, "length": 275, "protein_name": "Cytosolic Fe-S cluster assembly factor NUBP2", "gene_name": "Nubp2", "organism": "Mouse", "refseq_name": "cytosolic Fe-S cluster assembly factor NUBP2 isoform 1", "refseq_ac": "NP_036086", "gene_names_uniprotkb": "Nubp2", "gene_names_refseq": "D17Wsu11e; Nubp2", "protein_names_uniprotkb": "Cytosolic Fe-S cluster assembly factor NUBP2; NBP 2; Nucleotide-binding protein 2", "protein_names_refseq": "cytosolic Fe-S cluster assembly factor NUBP2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:26426)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10486206;16638812;21750661;22645316;23807208;26153462;27802388;31219806;31733190;35984892;37507081;37828378", "class_list": "", "function": "Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure (PubMed:23807208)., [UniProtKB, PubMed, HAMAP, UniProtKB, UniProtKB]; KATNAL2 isoforms interact with themselves, with each other and with Nubp1 and Nubp2., [RefSeq, PubMed]; KIFC5A interacts with nucleotide-binding proteins 1 and 2 (Nubp1 and Nubp2). Nubp1 and Nubp2 also interact with each other., [RefSeq, PubMed]; Nubp2 is required for cranial neural crest survival in the mouse., [RefSeq, PubMed]; The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051536 iron-sulfur cluster binding;GO:0140663 ATP-dependent FeS chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005814 centriole;GO:0005930 axoneme", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9R061-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHY6-1", "uniprot_id": "P66A_MOUSE", "mass": 67334.0, "length": 629, "protein_name": "Transcriptional repressor p66 alpha", "gene_name": "Gatad2a", "organism": "Mouse", "refseq_name": "transcriptional repressor p66 alpha isoform b", "refseq_ac": "NP_001106817", "gene_names_uniprotkb": "Gatad2a", "gene_names_refseq": "1110066C11Rik; Gatad2a", "protein_names_uniprotkb": "Transcriptional repressor p66 alpha; GATA zinc finger domain-containing protein 2A", "protein_names_refseq": "GATA zinc finger domain-containing protein 2A; transcriptional repressor p66 alpha isoform b; transcriptional repressor p66 alpha", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:234366); (R-MMU-3214815); (R-MMU-6804758); (R-MMU-73762); (R-MMU-8943724); (R-MMU-9937850); (R-MMU-9940951)", "pathway_count": 7, "publication_count": 20, "publication_id_list": "17242355;18630941;19144319;21183079;21750661;22517741;22645316;24129315;29187734;29237092;30122475;32782141;32848054;34428180;34887587;35822049;36084651;36852467;40885482;40997131", "class_list": "", "function": "It validates a distinct molecular axis, Gatad2a-Chd4-Mbd3, within Mbd3/NuRD as being critical for blocking reestablishment of naive pluripotency and further highlight signaling-dependent and post-translational modifications of Mbd3/NuRD that influence its interactions and assembly., [RefSeq, PubMed]; Transcriptional repressor. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 18, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 18, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 18, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTQ2;Q8VEC9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0016581 NuRD complex", "go_biological_process": "GO:0001842 neural fold formation;GO:0010172 embryonic body morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q8CHY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q50L43-1", "uniprot_id": "PA24D_MOUSE", "mass": 93042.0, "length": 825, "protein_name": "Cytosolic phospholipase A2 delta", "gene_name": "Pla2g4d", "organism": "Mouse", "refseq_name": "cytosolic phospholipase A2 delta", "refseq_ac": "NP_001019308", "gene_names_uniprotkb": "Pla2g4d", "gene_names_refseq": "2610311B01Rik; Pla2delta; Pla2g4d; cPLA2delta", "protein_names_uniprotkb": "Cytosolic phospholipase A2 delta; 3.1.1.4; Phospholipase A2 group IVD; cPLA2-delta", "protein_names_refseq": "cPLA2-delta; cytosolic phospholipase A2 delta", "tax_id": 10090, "disease": "", "pathway": " (mmu:78390); (R-MMU-1482788); (R-MMU-1482801); (R-MMU-1482839); (R-MMU-1482922); (R-MMU-1482925); (R-MMU-1483115); (R-MMU-1483166)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "15866882;31796632", "class_list": "", "function": "Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (PubMed:15866882). Compared to its human ortholog, may have no preference for the fatty acid found at the sn-2 position (PubMed:15866882)., [UniProtKB, PubMed]; Murine cytosolic phospholipases A2 delta, epsilon, and zeta form a gene cluster with cPLA(2)beta, [RefSeq, PubMed]; The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A2 coordinates acute wound healing and repair. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AQJ1;Q3TJC5", "ec_number_list": "3.5.1.1;3.1.1.47;3.1.1.5;3.1.1.-;1.11.1.27;3.1.1.4;2.3.1.23;2.3.1.43;3.1.1.32;3.1.1.3;3.1.2.2;3.1.2.22;3.1.2.-;3.1.1.13;3.1.1.6;2.3.1.-;3.4.11.-;2.3.1.51;3.1.4.-", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0046475 glycerophospholipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q50L43-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTW9-1", "uniprot_id": "PAK4_MOUSE", "mass": 64623.0, "length": 593, "protein_name": "Serine/threonine-protein kinase PAK 4", "gene_name": "Pak4", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase PAK 4", "refseq_ac": "NP_081746", "gene_names_uniprotkb": "Pak4; Kiaa1142", "gene_names_refseq": "5730488L07Rik; Pak4; mKIAA1142", "protein_names_uniprotkb": "Serine/threonine-protein kinase PAK 4; 2.7.11.1; PAK-4; p21-activated kinase 4", "protein_names_refseq": "PAK-4; p21 protein (Cdc42/Rac)-activated kinase 4; p21-activated kinase 4; serine/threonine-protein kinase PAK 4", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": " (mmu:70584); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013407); (R-MMU-9013408); (R-MMU-9013420); (R-MMU-9013423); (R-MMU-9013424)", "pathway_count": 9, "publication_count": 17, "publication_id_list": "11413130;11668177;12529371;14517283;15345747;17242355;19144319;21183079;21381077;21382368;25428506;30084848;30779550;37591884;38216738;38797819;39127697", "class_list": "", "function": "Inhibition of P21-activated kinases 1 and 4 synergistically suppresses the growth of pancreatic cancer by stimulating anti-tumour immunity. Publication Status: Online-Only, [RefSeq, PubMed]; P21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL., [RefSeq, PubMed]; P21-activated kinase 4 suppresses fatty acid beta-oxidation and ketogenesis by phosphorylating NCoR1. Erratum:[Nat Commun. 2023 Nov 2;14(1):7007. doi: 10.1038/s41467-023-42957-1. PMID: 37919334] Publication Status: Online-Only, [RefSeq, PubMed]; PAK4 has a role in neural tube development, [RefSeq, PubMed]; PAK4 interacts with KGF receptor and mediate anti-apoptosis effects of KGF on epithelial cells., [RefSeq, PubMed]; PAK4 phosphorylates and inhibits AMPKalpha to control glucose uptake. Erratum:[Nat Commun. 2025 Oct 13;16(1):9055. doi: 10.1038/s41467-025-64713-3. PMID: 41083498] Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPX0;Q80Z97;Q9CS71", "ec_number_list": "2.7.11.1;2.7.11.25;2.1.1.13;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;3.6.5.-;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.10.4;2.7.1.153;2.7.1.137;3.6.5.2;2.7.1.40;2.7.11.21;2.3.1.168;2.7.11.39;3.4.19.12;2.3.1.-;3.1.4.4;3.6.4.6;2.7.10.1;2.7.11.31;1.6.3.-;2.3.2.27;2.3.1.48;4.1.1.32;1.16.1.-;2.7.11.38;3.6.1.-;3.6.-.-;2.1.2.1;2.3.2.26;7.1.1.2;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process;GO:0045766 positive regulation of angiogenesis;GO:0050821 protein stabilization;GO:0060996 dendritic spine development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8BTW9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CCS6-1", "uniprot_id": "PABP2_MOUSE", "mass": 32297.0, "length": 302, "protein_name": "Polyadenylate-binding protein 2", "gene_name": "Pabpn1", "organism": "Mouse", "refseq_name": "polyadenylate-binding protein 2", "refseq_ac": "NP_062275", "gene_names_uniprotkb": "Pabpn1; Pab2; Pabp2", "gene_names_refseq": "PAB2; Pabp3; Pabpn1; mPABII", "protein_names_uniprotkb": "Polyadenylate-binding protein 2; Nuclear poly(A)-binding protein 1; PABII; PABP-2; Poly(A)-binding protein 2; Poly(A)-binding protein II; Polyadenylate-binding nuclear protein 1", "protein_names_refseq": "PABII; PABP-2; nuclear poly(A)-binding protein 1; poly(A) binding protein II; poly(A)-binding protein 2; polyadenylate-binding nuclear protein 1; polyadenylate-binding protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:54196); (R-MMU-72187); (R-MMU-73856); (R-MMU-77595); (R-MMU-9770562); (R-MMU-9930044)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "21750661;22844456;24129315;34428180;36288343;37356722;37661812;38213032;9434149", "class_list": "", "function": "Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and also controls the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; PABPN1 loss-of-function causes APA-shift in oculopharyngeal muscular dystrophy., [RefSeq, PubMed]; The RNA-binding protein ZC3H11A interacts with the nuclear poly(A)-binding protein PABPN1 and alters polyadenylation of viral transcripts., [RefSeq, PubMed]; The polyA tail facilitates splicing of last introns with weak 3' splice sites via PABPN1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35935", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0070063 RNA polymerase binding;GO:0008143 poly(A) binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006397 mRNA processing;GO:0000165 MAPK cascade;GO:0071222 cellular response to lipopolysaccharide;GO:1904247 positive regulation of polynucleotide adenylyltransferase activity", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8CCS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PDH0-1", "uniprot_id": "PHLB1_MOUSE", "mass": 150070.0, "length": 1371, "protein_name": "Pleckstrin homology-like domain family B member 1", "gene_name": "Phldb1", "organism": "Mouse", "refseq_name": "pleckstrin homology-like domain family B member 1 isoform 6", "refseq_ac": "NP_705765", "gene_names_uniprotkb": "Phldb1; Kiaa0638; Ll5a", "gene_names_refseq": "D330037A14Rik; Ll5alpha; Ll5a; Phldb1", "protein_names_uniprotkb": "Pleckstrin homology-like domain family B member 1; Protein LL5-alpha", "protein_names_refseq": "pleckstrin homology-like domain family B member 1 isoform 6; protein LL5-alpha", "tax_id": 10090, "disease": "osteogenesis imperfecta (Disease Ontology:DOID:12347)", "pathway": " (mmu:102693)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;14532993;16452087;17242355;19144319;20587420;21183079;21750661;24129315;32782141;34428180;34887587;35820727;37507081;40885482", "class_list": "", "function": "PHLDB1 is a novel modulator of Akt protein kinase activation by insulin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 28, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q80TV2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0045180 basal cortex", "go_biological_process": "GO:0071711 basement membrane organization", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q6PDH0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBD5-1", "uniprot_id": "PELP1_MOUSE", "mass": 118069.0, "length": 1123, "protein_name": "Proline-, glutamic acid- and leucine-rich protein 1", "gene_name": "Pelp1", "organism": "Mouse", "refseq_name": "proline-, glutamic acid- and leucine-rich protein 1", "refseq_ac": "NP_083507", "gene_names_uniprotkb": "Pelp1; Mnar", "gene_names_refseq": "4930563C04Rik; MNAR; Pelp1", "protein_names_uniprotkb": "Proline-, glutamic acid- and leucine-rich protein 1; Modulator of non-genomic activity of estrogen receptor", "protein_names_refseq": "modulator of non-genomic activity of estrogen receptor; proline-, glutamic acid- and leucine-rich protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75273); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11481323;12682072;15345747;19131326;21183079;22872859;25377474;25428506;26627258;30084848;31219806;34428180;37290329;39627609", "class_list": "", "function": "Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (By similarity)., [UniProtKB, UniProtKB, PubMed]; Functional study of human homolog., [RefSeq, PubMed]; MiR-195-5p is involved in testicular ischemia/reperfusion injury by directly targeting PELP1 and regulating spermatogonia pyroptosis., [RefSeq, PubMed]; PELP1 is essential for the extranuclear signaling and neuroprotective actions of 17-beta estradiol in the hippocampal CA1 region after global cerebral ischemia., [RefSeq, PubMed]; Recruitment of the protein complex 5FMC to Zbp-89, a zinc-finger transcription factor, affects its sumoylation status and transactivation potential.[5FMC], [RefSeq, PubMed]; These results further support the hypothesis that PELP1 deregulation has the potential to promote breast tumorigenesis in vivo and represent a novel model for future investigation into molecular mechanisms of PELP1-mediated tumorigenesis., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q5F2E2;Q6PEM0;Q91YM9", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0032183 SUMO binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000791 euchromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006364 rRNA processing;GO:0071391 cellular response to estrogen stimulus", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9DBD5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGT8-1", "uniprot_id": "PHIPL_MOUSE", "mass": 42341.0, "length": 375, "protein_name": "Phytanoyl-CoA hydroxylase-interacting protein-like", "gene_name": "Phyhipl", "organism": "Mouse", "refseq_name": "phytanoyl-CoA hydroxylase-interacting protein-like isoform 2", "refseq_ac": "NP_001156318", "gene_names_uniprotkb": "Phyhipl", "gene_names_refseq": "4921522K17Rik; PHY2; Phyhipl", "protein_names_uniprotkb": "Phytanoyl-CoA hydroxylase-interacting protein-like", "protein_names_refseq": "phytanoyl-CoA hydroxylase-interacting protein-like isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:70911)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;35822049", "class_list": "", "function": "May play a role in the development of the central system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A4FVA0;Q8BZJ1;Q8C0X3;Q8CFU1;Q8R0C1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BGT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27659-1", "uniprot_id": "RL3_MOUSE", "mass": 46110.0, "length": 403, "protein_name": "Large ribosomal subunit protein uL3", "gene_name": "Rpl3", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL3", "refseq_ac": "NP_038790", "gene_names_uniprotkb": "Rpl3", "gene_names_refseq": "F2; J1; Rpl3", "protein_names_uniprotkb": "Large ribosomal subunit protein uL3; 60S ribosomal protein L3; J1 protein", "protein_names_refseq": "60S ribosomal protein L3; large ribosomal subunit protein uL3; ribosomal protein L3 homolog", "tax_id": 10090, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479)", "pathway": " (mmu:27367); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 26, "publication_id_list": "15592455;16479539;1711497;21183079;21750661;23806337;25428506;26100019;2628163;26740625;28315936;29187734;30084848;31219806;33300544;34203471;34428180;35820727;35984892;36210013;36288343;36517592;36882085;37453647;37828378;9798653", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]; Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O89071;Q91VJ6", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008097 5S rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0005840 ribosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0006412 translation;GO:0071353 cellular response to interleukin-4;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P27659-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62900-1", "uniprot_id": "RL31_MOUSE", "mass": 14463.0, "length": 125, "protein_name": "Large ribosomal subunit protein eL31", "gene_name": "Rpl31", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL31", "refseq_ac": "NP_001239147", "gene_names_uniprotkb": "Rpl31", "gene_names_refseq": "Dts; Rpl31", "protein_names_uniprotkb": "Large ribosomal subunit protein eL31; 60S ribosomal protein L31", "protein_names_refseq": "60S ribosomal protein L31; large ribosomal subunit protein eL31", "tax_id": 10090, "disease": "", "pathway": " (mmu:114641); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 15, "publication_id_list": "21183079;21750661;23806337;25605945;31219806;33649389;34428180;35820727;35984892;36288343;36517592;37453647;37507081;37828378;39627609", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]; Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P12947", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P62900-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1R9-1", "uniprot_id": "RL34_MOUSE", "mass": 13293.0, "length": 117, "protein_name": "Large ribosomal subunit protein eL34", "gene_name": "Rpl34", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL34", "refseq_ac": "NP_001005859", "gene_names_uniprotkb": "Rpl34", "gene_names_refseq": "1100001I22Rik; Rpl34", "protein_names_uniprotkb": "Large ribosomal subunit protein eL34; 60S ribosomal protein L34", "protein_names_refseq": "60S ribosomal protein L34; large ribosomal subunit protein eL34", "tax_id": 10090, "disease": "", "pathway": " (mmu:619547); (mmu:68436); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 12, "publication_count": 11, "publication_id_list": "21750661;22872234;23806337;26495903;31219806;34428180;35820727;36210013;36517592;37507081;39627609", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q497V4", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation;GO:0140236 translation at presynapse", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9D1R9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR57-1", "uniprot_id": "RL14_MOUSE", "mass": 23564.0, "length": 217, "protein_name": "Large ribosomal subunit protein eL14", "gene_name": "Rpl14", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL14", "refseq_ac": "NP_080250", "gene_names_uniprotkb": "Rpl14", "gene_names_refseq": "3100001N19Rik; CAG-ISL-7; CTG-B33; L14; Rpl14", "protein_names_uniprotkb": "Large ribosomal subunit protein eL14; 60S ribosomal protein L14", "protein_names_refseq": "60S ribosomal protein L14; large ribosomal subunit protein eL14", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:67115); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 12, "publication_id_list": "21183079;21750661;23806337;26740625;33300544;35820727;36288343;36517592;37453647;37828378;39627609;39927985", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8Q1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0045202 synapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0042273 ribosomal large subunit biogenesis;GO:0006941 striated muscle contraction;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9CR57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1L3T7-1", "uniprot_id": "RIPR3_MOUSE", "mass": 104161.0, "length": 938, "protein_name": "RIPOR family member 3", "gene_name": "Ripor3", "organism": "Mouse", "refseq_name": "RIPOR family member 3", "refseq_ac": "NP_001074177", "gene_names_uniprotkb": "Ripor3; Fam65c", "gene_names_refseq": "2310033K02Rik; Fam65c; Gm124; Ripor3", "protein_names_uniprotkb": "RIPOR family member 3", "protein_names_refseq": "RIPOR family member 3; family with sequence similarity 65, member C; protein FAM65C", "tax_id": 10090, "disease": "", "pathway": " (mmu:69553)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A1L3T7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47962-1", "uniprot_id": "RL5_MOUSE", "mass": 34401.0, "length": 297, "protein_name": "Large ribosomal subunit protein uL18", "gene_name": "Rpl5", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL18", "refseq_ac": "NP_058676", "gene_names_uniprotkb": "Rpl5", "gene_names_refseq": "Rpl5; Ska23; Ska; Skax23; U21RNA", "protein_names_uniprotkb": "Large ribosomal subunit protein uL18; 60S ribosomal protein L5", "protein_names_refseq": "60S ribosomal protein L5; large ribosomal subunit protein uL18", "tax_id": 10090, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); Diamond-Blackfan anemia 6 (Disease Ontology:DOID:0111879); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); glioblastoma (Disease Ontology:DOID:3068); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (mmu:100503670); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 16, "publication_id_list": "21750661;23806337;25605945;26495903;26740625;28315936;29187734;33300544;34428180;34464976;35820727;36517592;37453647;39627609;39927985;7937132", "class_list": "", "function": "A new murine Rpl5 (uL18) mutation provides a unique model of variably penetrant Diamond-Blackfan anemia., [RefSeq, PubMed]; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (By similarity). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (By similarity). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (By similarity). As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (By similarity). It also couples ribosome biogenesis to p53/TP53 activation (By similarity). As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CR19", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0031625 ubiquitin protein ligase binding;GO:0003730 mRNA 3'-UTR binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0008097 5S rRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0010628 positive regulation of gene expression;GO:0042273 ribosomal large subunit biogenesis;GO:1901796 regulation of signal transduction by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P47962-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70425-1", "uniprot_id": "RIT2_MOUSE", "mass": 24802.0, "length": 217, "protein_name": "GTP-binding protein Rit2", "gene_name": "Rit2", "organism": "Mouse", "refseq_name": "GTP-binding protein Rit2", "refseq_ac": "NP_033091", "gene_names_uniprotkb": "Rit2; Rin; Roc2", "gene_names_refseq": "RIBA; Rin; Rit2; Roc2", "protein_names_uniprotkb": "GTP-binding protein Rit2; 3.6.5.2; Ras-like protein expressed in neurons; Ras-like without CAAX protein 2", "protein_names_refseq": "GTP-binding protein Rit2; GTP-binding protein Roc2; RAS-like protein expressed in neuron; ras-like protein expressed in neurons; ras-like without CAAX protein 2", "tax_id": 10090, "disease": "acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (mmu:19762)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10545207;11877426;12099688;12934100;21750661;23805044;31277075;32132171;8824319", "class_list": "", "function": "Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator., [UniProtKB, PubMed]; Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function., [RefSeq, PubMed]; Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact., [RefSeq, PubMed]; Stimulation of PC6 cells with either epidermal growth factor or nerve growth factor (NGF) results in rapid activation of Rin, [RefSeq, PubMed]; The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation, [RefSeq, PubMed]; These studies confirm the expression of RIT2 in retinal neuronal cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UST1;Q3UUP4;Q8BQT5;Q9QWX5", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003924 GTPase activity;GO:0005516 calmodulin binding;GO:0005525 GTP binding;GO:0030215 semaphorin receptor binding", "go_cellular_component": "GO:0097447 dendritic tree;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0032507 maintenance of protein location in cell;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010976 positive regulation of neuron projection development;GO:0030100 regulation of endocytosis;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P70425-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55142-1", "uniprot_id": "RL35A_MOUSE", "mass": 12554.0, "length": 110, "protein_name": "Large ribosomal subunit protein eL33", "gene_name": "Rpl35a", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL33", "refseq_ac": "NP_001123956", "gene_names_uniprotkb": "Rpl35a", "gene_names_refseq": "2810431L15Rik; Rpl35a; Rpl35", "protein_names_uniprotkb": "Large ribosomal subunit protein eL33; 60S ribosomal protein L35a", "protein_names_refseq": "60S ribosomal protein L35a; large ribosomal subunit protein eL33", "tax_id": 10090, "disease": "Diamond-Blackfan anemia 5 (Disease Ontology:DOID:0111883); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (mmu:57808); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 8, "publication_id_list": "11448102;22645316;23806337;26495903;34428180;36517592;37453647;39627609", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Required for the proliferation and viability of hematopoietic cells (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0042273 ribosomal large subunit biogenesis;GO:0006941 striated muscle contraction;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O55142-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53026-1", "uniprot_id": "RL10A_MOUSE", "mass": 24916.0, "length": 217, "protein_name": "Large ribosomal subunit protein uL1", "gene_name": "Rpl10a", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rpl10a; Nedd-6; Nedd6", "gene_names_refseq": "", "protein_names_uniprotkb": "Large ribosomal subunit protein uL1; 60S ribosomal protein L10a; CSA-19; NEDD-6; Neural precursor cell expressed developmentally down-regulated protein 6", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 10, "publication_count": 21, "publication_id_list": "1378265;17947660;21540332;21750661;22645316;23576753;23806337;24788674;25428506;25605945;30084848;31219806;34203471;34428180;35820727;36288343;37453647;37507081;37828378;39627609;7609734", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation;GO:0140236 translation at presynapse", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P53026-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62751-1", "uniprot_id": "RL23A_MOUSE", "mass": 17695.0, "length": 156, "protein_name": "Large ribosomal subunit protein uL23", "gene_name": "Rpl23a", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL23", "refseq_ac": "NP_997406", "gene_names_uniprotkb": "Rpl23a", "gene_names_refseq": "MDA20; Rpl23a", "protein_names_uniprotkb": "Large ribosomal subunit protein uL23; 60S ribosomal protein L23a", "protein_names_refseq": "60S ribosomal protein L23a; large ribosomal subunit protein uL23", "tax_id": 10090, "disease": "", "pathway": " (mmu:268449); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 18, "publication_id_list": "20668449;23806337;24463520;25605945;28315936;31361958;33300544;33649389;33725478;34428180;34782045;35820727;35984892;36288343;36517592;37453647;37828378;39627609", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity)., [UniProtKB, UniProtKB, PubMed]; Ionizing Radiation-Induced RPL23a Reduction Regulates Apoptosis via RPL11-MDM2-p53 Pathway in Mouse Spermatogonia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P29316;P39024;Q92774", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding;GO:1904841 TORC2 complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation;GO:0140236 translation at presynapse", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P62751-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62892-1", "uniprot_id": "RL39_MOUSE", "mass": 6407.0, "length": 51, "protein_name": "Large ribosomal subunit protein eL39", "gene_name": "Rpl39", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL39", "refseq_ac": "NP_080331", "gene_names_uniprotkb": "Rpl39", "gene_names_refseq": "2810465O16Rik; Rpl39", "protein_names_uniprotkb": "Large ribosomal subunit protein eL39; 60S ribosomal protein L39", "protein_names_refseq": "60S ribosomal protein L39; large ribosomal subunit protein eL39", "tax_id": 10090, "disease": "", "pathway": " (mmu:67248); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 6, "publication_id_list": "22404850;26740625;34428180;34428590;35820727;36517592", "class_list": "", "function": "Deletion of ribosomal paralogs Rpl39 and Rpl39l compromises cell proliferation via protein synthesis and mitochondrial activity., [RefSeq, PubMed]; RNA-binding component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:34428590, PubMed:36517592)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02404;P39025;Q9BYF2", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0019731 antibacterial humoral response;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P62892-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62911-1", "uniprot_id": "RL32_MOUSE", "mass": 15860.0, "length": 135, "protein_name": "Large ribosomal subunit protein eL32", "gene_name": "Rpl32", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL32", "refseq_ac": "NP_742083", "gene_names_uniprotkb": "Rpl32", "gene_names_refseq": "Rpl32; rpL32-3A", "protein_names_uniprotkb": "Large ribosomal subunit protein eL32; 60S ribosomal protein L32", "protein_names_refseq": "60S ribosomal protein L32; large ribosomal subunit protein eL32; snoRNA MBI-141", "tax_id": 10090, "disease": "", "pathway": " (mmu:19951); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;23806337;31219806;34428180;35820727;36288343;36517592;37453647;37507081;6327068", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P02433;Q3UFJ7", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse;GO:0005840 ribosome", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0071549 cellular response to dexamethasone stimulus;GO:0006412 translation;GO:0006941 striated muscle contraction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P62911-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P67984-1", "uniprot_id": "RL22_MOUSE", "mass": 14759.0, "length": 128, "protein_name": "Large ribosomal subunit protein eL22", "gene_name": "Rpl22", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL22 isoform a", "refseq_ac": "NP_033105", "gene_names_uniprotkb": "Rpl22", "gene_names_refseq": "2700038K18Rik; Rpl22", "protein_names_uniprotkb": "Large ribosomal subunit protein eL22; 60S ribosomal protein L22; Heparin-binding protein HBp15", "protein_names_refseq": "60S ribosomal protein L22; heparin-binding protein HBp15; large ribosomal subunit protein eL22 isoform a; large ribosomal subunit protein eL22", "tax_id": 10090, "disease": "", "pathway": " (mmu:19934); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 10, "publication_id_list": "17555992;21183079;23806337;33725478;34428180;36288343;36517592;37453647;39627609;8135813", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]; Rpl22 deficiency activated a p53-dependent checkpoint that produced a remarkably selective block in alphabeta T cell development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P41104", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0046632 alpha-beta T cell differentiation;GO:0002181 cytoplasmic translation;GO:0140236 translation at presynapse;GO:0140242 translation at postsynapse", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P67984-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P99027-1", "uniprot_id": "RLA2_MOUSE", "mass": 11651.0, "length": 115, "protein_name": "Large ribosomal subunit protein P2", "gene_name": "Rplp2", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein P2 isoform a", "refseq_ac": "NP_080296", "gene_names_uniprotkb": "Rplp2", "gene_names_refseq": "2700049I22Rik; Rplp2", "protein_names_uniprotkb": "Large ribosomal subunit protein P2; 60S acidic ribosomal protein P2", "protein_names_refseq": "60S acidic ribosomal protein P2; large ribosomal subunit protein P2 isoform a; large ribosomal subunit protein P2; ribosomal protein, large P2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67186); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;15345747;16479539;17242355;18630941;19131326;19144319;20173027;21183079;22517741;23806337;25428506;25605945;28315936;29237092;30084848;30779550;32152506;32848054;34428180;36852467;37453647;37828378;39395807;40021952;40885482", "class_list": "", "function": "Plays an important role in the elongation step of protein synthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKY3;Q9CQ99;Q9CZJ8", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0043021 ribonucleoprotein complex binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse;GO:0005840 ribosome", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation;GO:0002182 cytoplasmic translational elongation", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P99027-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2WG76-1", "uniprot_id": "RIPP2_MOUSE", "mass": 14305.0, "length": 128, "protein_name": "Protein ripply2", "gene_name": "Ripply2", "organism": "Mouse", "refseq_name": "protein ripply2 isoform 3", "refseq_ac": "NP_001032996", "gene_names_uniprotkb": "Ripply2", "gene_names_refseq": "C030002E08Rik; Gm1122; Ripply2", "protein_names_uniprotkb": "Protein ripply2", "protein_names_refseq": "protein ripply2 isoform 3; protein ripply2; ripply2 homolog", "tax_id": 10090, "disease": "spondylocostal dysostosis (Disease Ontology:DOID:0050568); spondylocostal dysostosis 6 (Disease Ontology:DOID:0112360)", "pathway": " (mmu:382089)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16326386;17360776;17531978;17937396;25641698;29761784;30779550", "class_list": "", "function": "Compares Ripply proteins in zebrafish, mouse, human, and amphioxus., [RefSeq, PubMed]; Defects in segmentation of the axial skeleton were observed in the ripply2 homozygous mutant mice., [RefSeq, PubMed]; Findings show that Ripply2 is expressed in the anterior presomitic mesoderm and that it lies downstream of Wnt3a; data are consistent with Ripply2 functioning as a segment boundary determination gene during mammalian embryogenesis, [RefSeq, PubMed]; Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal polarity in somites., [UniProtKB, PubMed, PubMed]; Ripply2 represses Tbx6 in a Mesp2-independent manner, which contributes to the accurate segmental border formation., [RefSeq, PubMed]; Ripply2-Mesp2 negative-feedback loop is essential for the periodic generation of the rostro-caudal polarity within a somite., [RefSeq, PubMed]; The authors succeeded in reproducing in vivo events using a mouse embryonic stem cell induction system, in which Tbx6 degradation occurred via Ripply2. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNN5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0009798 axis specification;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway;GO:0001756 somitogenesis;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q2WG76-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FE6-1", "uniprot_id": "RIPR1_MOUSE", "mass": 132352.0, "length": 1223, "protein_name": "Rho family-interacting cell polarization regulator 1", "gene_name": "Ripor1", "organism": "Mouse", "refseq_name": "rho family-interacting cell polarization regulator 1", "refseq_ac": "NP_001074710", "gene_names_uniprotkb": "Ripor1; Fam65a; Kiaa1930", "gene_names_refseq": "2310066E14Rik; Fam65a; Ripor1", "protein_names_uniprotkb": "Rho family-interacting cell polarization regulator 1", "protein_names_refseq": "family with sequence similarity 65, member A; protein FAM65A; rho family-interacting cell polarization regulator 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75687)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;17242355;17251388;19144319;21183079;25428506;30084848;30779550;34428180;34678516", "class_list": "", "function": "Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration. Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation. Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "G5E8A2;Q80T73;Q8K0T1;Q9D6R4", "ec_number_list": "", "go_molecular_function": "GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0031252 cell leading edge", "go_biological_process": "GO:1990869 cellular response to chemokine;GO:0030335 positive regulation of cell migration;GO:0090316 positive regulation of intracellular protein transport;GO:0007266 Rho protein signal transduction;GO:0009611 response to wounding", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q68FE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BP67-1", "uniprot_id": "RL24_MOUSE", "mass": 17779.0, "length": 157, "protein_name": "Large ribosomal subunit protein eL24", "gene_name": "Rpl24", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL24", "refseq_ac": "NP_077180", "gene_names_uniprotkb": "Rpl24", "gene_names_refseq": "0610008L05Rik; Bst; Rpl24; Zbtb11", "protein_names_uniprotkb": "Large ribosomal subunit protein eL24; 60S ribosomal protein L24", "protein_names_refseq": "60S ribosomal protein L24; belly spot and tail; large ribosomal subunit protein eL24", "tax_id": 10090, "disease": "optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (mmu:68193); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 15, "publication_id_list": "18250455;21183079;23806337;25428506;26495903;30779550;31219806;33300544;34428180;35820727;36288343;36517592;37453647;38261097;39627609", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]; Ribosomal protein L24 mediates mammalian microRNA processing in an evolutionarily conserved manner. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P38663;Q58EA4", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0060041 retina development in camera-type eye;GO:0006412 translation;GO:0010458 exit from mitosis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8BP67-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BQZ4-1", "uniprot_id": "RLGPB_MOUSE", "mass": 165200.0, "length": 1484, "protein_name": "Ral GTPase-activating protein subunit beta", "gene_name": "Ralgapb", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ralgapb; Kiaa1219", "gene_names_refseq": "", "protein_names_uniprotkb": "Ral GTPase-activating protein subunit beta; p170", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:228850)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16490346;21183079;21750661;31219806;33300544;34428180", "class_list": "", "function": "Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80TH5;Q8BQN1", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0032880 regulation of protein localization;GO:0090630 activation of GTPase activity;GO:0060178 regulation of exocyst localization;GO:0032484 Ral protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BQZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8M4-1", "uniprot_id": "RL7L_MOUSE", "mass": 28544.0, "length": 246, "protein_name": "Large ribosomal subunit protein uL30-like 1", "gene_name": "Rpl7l1", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL30-like 1", "refseq_ac": "NP_079709", "gene_names_uniprotkb": "Rpl7l1", "gene_names_refseq": "1500016H10Rik; Rpl7l1", "protein_names_uniprotkb": "Large ribosomal subunit protein uL30-like 1; 60S ribosomal protein L7-like 1", "protein_names_refseq": "60S ribosomal protein L7-like 1; large ribosomal subunit protein uL30-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66229)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21183079;21750661;23211737;25428506;30779550;31219806;34428180", "class_list": "", "function": "Rpl7l1 is required for the blastocyst formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0001825 blastocyst formation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D8M4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24549-1", "uniprot_id": "AL1A1_MOUSE", "mass": 54468.0, "length": 501, "protein_name": "Aldehyde dehydrogenase 1A1", "gene_name": "Aldh1a1", "organism": "Mouse", "refseq_name": "aldehyde dehydrogenase 1A1", "refseq_ac": "NP_038495", "gene_names_uniprotkb": "Aldh1a1; Ahd-2; Ahd2; Aldh1", "gene_names_refseq": "ALDH-E1; ALHDII; Ahd-2; Ahd2; Aldh1a1; Aldh1a2; Aldh1; E1; Raldh1", "protein_names_uniprotkb": "Aldehyde dehydrogenase 1A1; 1.2.1.19; 1.2.1.28; 1.2.1.36; 1.2.1.3; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; RALDH 1; RalDH1; Retinal dehydrogenase 1", "protein_names_refseq": "3-deoxyglucosone dehydrogenase; RALDH 1; alcohol dehydrogenase family 1, subfamily A1; alcohol dehydrogenase family 1, subfamily A2; aldehyde dehydrogenase 1, liver cytosolic (class 1); aldehyde dehydrogenase 1A1; aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase, cytosolic; retinal dehydrogenase 1", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); pancreatic cancer (Disease Ontology:DOID:1793); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11668); (R-MMU-5365859); (R-MMU-70350); (R-MMU-71384)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12851412;17567582;1935685;2055490;21750661;26430123;34428180;37453647;37507081;7993664", "class_list": "", "function": "Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:12851412). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (PubMed:12851412). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (Probable). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:17567582). Also functions downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity). Also has an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (PubMed:26430123)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQJ0;Q811J0", "ec_number_list": "1.2.1.3;1.2.1.48;1.2.1.36;1.2.1.19;1.2.1.28;1.2.1.5;1.2.1.94;1.2.1.7;1.1.1.-;1.1.1.62;1.1.1.105;1.7.1.-;1.2.1.31;1.2.1.8;1.2.1.47;1.2.1.46", "go_molecular_function": "GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0004028 3-chloroallyl aldehyde dehydrogenase activity;GO:0004029 aldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0030424 axon;GO:0045202 synapse", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0006979 response to oxidative stress;GO:0043065 positive regulation of apoptotic process;GO:0045471 response to ethanol;GO:0006081 aldehyde metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P24549-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BH79-1", "uniprot_id": "ANO10_MOUSE", "mass": 76188.0, "length": 659, "protein_name": "Anoctamin-10", "gene_name": "Ano10", "organism": "Mouse", "refseq_name": "anoctamin-10 isoform 2", "refseq_ac": "NP_001258802", "gene_names_uniprotkb": "Ano10; Tmem16k", "gene_names_refseq": "Ano10; Tmem16k", "protein_names_uniprotkb": "Anoctamin-10; Transmembrane protein 16K", "protein_names_refseq": "anoctamin-10 isoform 2; transmembrane protein 16K", "tax_id": 10090, "disease": "autosomal recessive spinocerebellar ataxia 10 (Disease Ontology:DOID:0050999)", "pathway": " (mmu:102566); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;18729231;19059364;20056604;20484733;21750661;22302790;25428506;25428507;25605945;27838374;30084848;30779550;31217287;31599954;32620747;34428180", "class_list": "", "function": "Data show the expression of Tmem16k during murine embryogenesis with an emphasis on the respiratory, digestive, skeletal, and integumentary systems., [RefSeq, PubMed]; Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1 (By similarity)., [UniProtKB]; During mouse cephalic development: detected in subventricular zone and differentiating fields, In organs developing through epithelial-mesenchymal interactions, such as the palate, tooth and tongue, [RefSeq, PubMed]; Mediates Ca2+-dependent phosphatidylserine scrambling in the endoplasmic reticulum, [RefSeq, PubMed]; Mutations in ANO10 cause cellular defects and genetic disorders through deranged local Ca(2+) signaling., [RefSeq, PubMed]; TMEM16K is an interorganelle regulator of endosomal sorting. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to inhibit anion conductance. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Dec 2012]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZD2;Q8BMS8;Q8BV74;Q8BW67;Q8R0U0;Q99LP0", "ec_number_list": "", "go_molecular_function": "GO:0005227 calcium-activated cation channel activity;GO:0005229 intracellularly calcium-gated chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016020 membrane", "go_biological_process": "GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8BH79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGM7-1", "uniprot_id": "AAKG3_MOUSE", "mass": 53849.0, "length": 489, "protein_name": "5'-AMP-activated protein kinase subunit gamma-3", "gene_name": "Prkag3", "organism": "Mouse", "refseq_name": "5'-AMP-activated protein kinase subunit gamma-3", "refseq_ac": "NP_714966", "gene_names_uniprotkb": "Prkag3", "gene_names_refseq": "AMPKg3L; AMPKg3S; Amkg3; Ampkg3; Prkag3", "protein_names_uniprotkb": "5'-AMP-activated protein kinase subunit gamma-3; AMPK gamma3; AMPK subunit gamma-3", "protein_names_refseq": "5'-AMP-activated protein kinase subunit gamma-3; AMP-activated protein kinase gamma subunit; AMPK gamma3; AMPK subunit gamma-3; protein kinase, AMP-activated, gamma 3 non-catatlytic subunit", "tax_id": 10090, "disease": "lethal congenital glycogen storage disease of heart (Disease Ontology:DOID:0090101); neurodegenerative disease (Disease Ontology:DOID:1289); Wolff-Parkinson-White syndrome (Disease Ontology:DOID:384)", "pathway": " (mmu:241113); (R-MMU-1632852); (R-MMU-380972); (R-MMU-5628897); (R-MMU-6804756); (R-MMU-9931269)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "14512293;14559719;14970697;21460634;21750661;33798773;34203471;34428180;37506328;39171449", "class_list": "", "function": "AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. AMPK also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. The AMPK gamma3 subunit is a non-catalytic subunit with a regulatory role in muscle energy metabolism. It mediates binding to AMP, ADP and ATP, leading to AMPK activation or inhibition: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive., [UniProtKB, UniProtKB]; AMPKgamma3 Controls Muscle Glucose Uptake in Recovery From Exercise to Recapture Energy Stores., [RefSeq, PubMed]; Compound- and fiber type-selective requirement of AMPKgamma3 for insulin-independent glucose uptake in skeletal muscle., [RefSeq, PubMed]; Gamma3 subunit of AMPK is highly expressed in fast-twitch glycolytic skeletal muscle, and wild-type gamma3 functions in the regulation of alpha1 catalytic activity, but it is not associated with changes in muscle glycogen concentrations, [RefSeq, PubMed]; The human AMPKgamma3 R225W mutation negatively impacts site-1 nucleotide binding and does not enhance basal AMPKgamma3-associated activity nor glycogen production in human or mouse skeletal muscle., [RefSeq, PubMed]; The observation that the AMPKgamma3 isoform is expressed primarily in white skeletal muscle, in which it is the predominant gamma-isoform, strongly suggests that gamma3 has a key role in this tissue, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VG42;Q80WK8;Q8CJ41", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0004679 AMP-activated protein kinase activity;GO:0016208 AMP binding;GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031588 nucleotide-activated protein kinase complex", "go_biological_process": "GO:0006110 regulation of glycolytic process;GO:0006633 fatty acid biosynthetic process;GO:0031669 cellular response to nutrient levels;GO:0042149 cellular response to glucose starvation;GO:0014873 response to muscle activity involved in regulation of muscle adaptation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BGM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P542-1", "uniprot_id": "ABCF1_MOUSE", "mass": 94945.0, "length": 837, "protein_name": "ATP-binding cassette sub-family F member 1", "gene_name": "Abcf1", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family F member 1", "refseq_ac": "NP_038882", "gene_names_uniprotkb": "Abcf1", "gene_names_refseq": "Abc50; Abcf1; D17Wsu166e; GCN20", "protein_names_uniprotkb": "ATP-binding cassette sub-family F member 1", "protein_names_refseq": "ATP-binding cassette sub-family F member 1; ATP-binding cassette, sub-family F (GCN20), member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:224742); (R-MMU-382556)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;15345747;17242355;18250455;18630941;19131326;19144319;21183079;21750661;26495903;28011936;28542262;30084848;30770245;34428180;34887587;37453647;39627609", "class_list": "", "function": "ABCF1, an ATP-Binding Cassette (ABC) family member protein, which possesses an E2 ubiquitin enzyme activity, through which it controls the Lipopolysaccharide (LPS)- Toll-like Receptor-4 (TLR4) mediated gram-negative insult by targeting key proteins for K63-polyubiquitination., [RefSeq, PubMed]; Abcf1 expression in embryos is required for development Publication Status: Online-Only, [RefSeq, PubMed]; Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NV71", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0008494 translation activator activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005840 ribosome", "go_biological_process": "GO:0006413 translational initiation;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q6P542-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R554-1", "uniprot_id": "OTU7A_MOUSE", "mass": 100797.0, "length": 926, "protein_name": "OTU domain-containing protein 7A", "gene_name": "Otud7a", "organism": "Mouse", "refseq_name": "OTU domain-containing protein 7A", "refseq_ac": "NP_570950", "gene_names_uniprotkb": "Otud7a; Cezanne2; Otud7", "gene_names_refseq": "Otud7a; Otud7", "protein_names_uniprotkb": "OTU domain-containing protein 7A; 3.4.19.12; Zinc finger protein Cezanne 2", "protein_names_refseq": "Cezanne 2 protein; OTU domain-containing protein 7A; zinc finger protein Cezanne 2", "tax_id": 10090, "disease": "chromosome 15q13.3 microdeletion syndrome (Disease Ontology:DOID:0060394)", "pathway": " (mmu:170711); (R-MMU-5689896)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;24129315;25428506;29395074;29395075;40885482", "class_list": "", "function": "Decreased OTUD7A dosage is a major contributor to the neurodevelopmental phenotypes associated with 15q13.3 microdeletion syndrome, [RefSeq, PubMed]; Deubiquitinase, which cleaves 'Lys-11'-linked polyubiquitin chains., [UniProtKB, UniProtKB]; OTUD7A is a major regulatory gene for 15q13.3 microdeletion syndrome phenotypes., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.19.12", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0035871 protein K11-linked deubiquitination;GO:0006508 proteolysis;GO:0016579 protein deubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8R554-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64092-1", "uniprot_id": "TFE3_MOUSE", "mass": 61536.0, "length": 572, "protein_name": "Transcription factor E3", "gene_name": "Tfe3", "organism": "Mouse", "refseq_name": "transcription factor E3 isoform b", "refseq_ac": "NP_001098666", "gene_names_uniprotkb": "Tfe3; Tcfe3", "gene_names_refseq": "F830016E06Rik; Tcfe3; Tfe-3; Tfe3; bHLHe33; mTFE3", "protein_names_uniprotkb": "Transcription factor E3; mTFE3", "protein_names_refseq": "transcription factor E3 isoform b", "tax_id": 10090, "disease": "lysosomal storage disease (Disease Ontology:DOID:3211); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (mmu:209446)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "16936731;1732746;20713358;21183079;21209915;21750661;22645316;23582324;24129315;27913603;29146937;30595499;31219806;32782141;32848054;34678516;35822049;36852467;40885482", "class_list": "", "function": "Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:16936731, PubMed:29146937). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (PubMed:16936731). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its inactivation (PubMed:27913603). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in transcription factor activity (PubMed:27913603). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (By similarity). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent TFE3 cytosolic retention and inactivation promotes exit from pluripotency (PubMed:23582324). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (By similarity). TFE3 activity is also involved in the inhibition of neuronal progenitor differentiation (PubMed:30595499). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (PubMed:27913603). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (PubMed:16936731). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (By similarity). It also binds very well to a USF/MLTF site (By similarity). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TSC22D1 at E-boxes in the gene proximal promoter (PubMed:20713358). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2AEW3;A2AEW4;Q3U8H0;Q3UMV4;Q3UT52;Q7TNC1;Q8BN29", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045785 positive regulation of cell adhesion;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q64092-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88708-1", "uniprot_id": "ORC4_MOUSE", "mass": 49982.0, "length": 433, "protein_name": "Origin recognition complex subunit 4", "gene_name": "Orc4", "organism": "Mouse", "refseq_name": "origin recognition complex subunit 4 isoform 1", "refseq_ac": "NP_036088", "gene_names_uniprotkb": "Orc4; Orc4l", "gene_names_refseq": "Orc4P; Orc4l; Orc4; mMmORC4", "protein_names_uniprotkb": "Origin recognition complex subunit 4", "protein_names_refseq": "origin recognition complex subunit 4 isoform 1", "tax_id": 10090, "disease": "Meier-Gorlin syndrome (Disease Ontology:DOID:0060306); Meier-Gorlin syndrome 2 (Disease Ontology:DOID:0080513)", "pathway": " (mmu:26428); (R-MMU-176187); (R-MMU-68616); (R-MMU-68689); (R-MMU-68949); (R-MMU-68962)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "10460412;12614612;21750661;28230328;30084848;32972244;34428180", "class_list": "", "function": "Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity). Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication., [UniProtKB]; The role of ORC4 in enucleation of Murine Erythroleukemia (MEL) cells is similar to that in oocyte polar body extrusion., [RefSeq, PubMed]; Together, these data demonstrate that ORC4 oligomerization is required to form the ORC4 cage and that it is required for polar body extrusion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91V62;Q9QYX1", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0005524 ATP binding;GO:0000166 nucleotide binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006260 DNA replication;GO:0051258 protein polymerization;GO:0006270 DNA replication initiation;GO:0040038 polar body extrusion after meiotic divisions", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88708-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q69ZU8-1", "uniprot_id": "ANKR6_MOUSE", "mass": 77982.0, "length": 712, "protein_name": "Ankyrin repeat domain-containing protein 6", "gene_name": "Ankrd6", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 6", "refseq_ac": "NP_001012453", "gene_names_uniprotkb": "Ankrd6; Kiaa0957", "gene_names_refseq": "Ankrd6", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 6; Diversin", "protein_names_refseq": "ankyrin repeat domain-containing protein 6; diversin", "tax_id": 10090, "disease": "", "pathway": " (mmu:140577)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12183362;12203740;20485683;21750661;25218921", "class_list": "", "function": "Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals., [UniProtKB, PubMed]; Results indicated that mAnkrd6 is a functional homolog of the Drosophila diego gene for mammalian planar cell polarity (PCP) regulation., [RefSeq, PubMed]; These data suggest that ankyrin repeat domain 6 (Ankrd6) may be involved in brain development in interaction not only with Celsr/Flamingo but also with other signaling pathways., [RefSeq, PubMed]; This gene encodes a protein which is thought to be involved in the Wnt signaling pathway and embryonic axis formation. Similar genes have been found in human, rhesus macaque, and zebrafish. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2ANZ0;Q6P1A8;Q8VHD9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway;GO:0030111 regulation of Wnt signaling pathway;GO:0007163 establishment or maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q69ZU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXQ1-1", "uniprot_id": "PDE7B_MOUSE", "mass": 51337.0, "length": 446, "protein_name": "3',5'-cyclic-AMP phosphodiesterase 7B", "gene_name": "Pde7b", "organism": "Mouse", "refseq_name": "3',5'-cyclic-AMP phosphodiesterase 7B isoform 1", "refseq_ac": "NP_001334295", "gene_names_uniprotkb": "Pde7b", "gene_names_refseq": "Pde7b", "protein_names_uniprotkb": "3',5'-cyclic-AMP phosphodiesterase 7B; 3.1.4.53; cAMP-specific phosphodiesterase 7B", "protein_names_refseq": "3',5'-cyclic-AMP phosphodiesterase 7B isoform 1; 3',5'-cyclic-AMP phosphodiesterase 7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B; cAMP-specific phosphodiesterase 7B", "tax_id": 10090, "disease": "", "pathway": " (mmu:29863); (R-MMU-418555)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10618442;10872825;21183079;21750661;22088971;25457552", "class_list": "", "function": "For the first time, it was demonstrated that the deletion of the PDE7B gene or the pharmacological inhibition of PDE7A and -B had no effect on ovalbumin-induced airway inflammation and airway hyperreactivity., [RefSeq, PubMed]; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:10872825). May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain (By similarity)., [UniProtKB, PubMed, UniProtKB]; It is one of the enzymes responsible for controlling specifically the intracellular levels of cyclic adenosine 3', 5'-monophosphate in the immune and central nervous systems., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1L3T2", "ec_number_list": "3.1.4.-;3.1.4.53;3.1.4.1;3.6.1.9;3.1.4.35;3.1.4.17;3.6.1.25;3.6.1.14", "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0006198 cAMP catabolic process;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QXQ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6Z1-1", "uniprot_id": "NOP56_MOUSE", "mass": 64464.0, "length": 580, "protein_name": "Nucleolar protein 56", "gene_name": "Nop56", "organism": "Mouse", "refseq_name": "nucleolar protein 56", "refseq_ac": "NP_077155", "gene_names_uniprotkb": "Nop56; Nol5a", "gene_names_refseq": "2310044F10Rik; Nol5a; Nop56", "protein_names_uniprotkb": "Nucleolar protein 56; Nucleolar protein 5A", "protein_names_refseq": "56kDa with KKE/D repeat; NOP56 ribonucleoprotein homolog; nucleolar protein 56; nucleolar protein 5A", "tax_id": 10090, "disease": "spinocerebellar ataxia 36 (Disease Ontology:DOID:0050983)", "pathway": " (mmu:67134); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;10864044;16452087;17242355;18630941;19131326;19144319;20173027;21183079;21683323;21750661;22872234;23582672;23806337;25153642;25428506;29187734;30084848;30779550;34428180;34887587;35820727;36852467;37507081;37828378;39627609", "class_list": "", "function": "Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The study suggests a progressive loss of nuclear proteins and subsequent RNA processing problems including a novel gene relating to amyotrophic lateral sclerosis (NOP56) under the motor neuron degeneration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UD45;Q8BVL1;Q8VDT2;Q99LT8;Q9CT15", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0030515 snoRNA binding;GO:1990226 histone methyltransferase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0001650 fibrillar center;GO:0070761 pre-snoRNP complex", "go_biological_process": "GO:0042274 ribosomal small subunit biogenesis;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q9D6Z1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23578-1", "uniprot_id": "ACRO_MOUSE", "mass": 48929.0, "length": 436, "protein_name": "Acrosin", "gene_name": "Acr", "organism": "Mouse", "refseq_name": "acrosin isoform 1 precursor", "refseq_ac": "NP_038483", "gene_names_uniprotkb": "Acr", "gene_names_refseq": "Acr", "protein_names_uniprotkb": "Acrosin; 3.4.21.10", "protein_names_refseq": "acrosin isoform 1 precursor; preproacrosin", "tax_id": 10090, "disease": "spermatogenic failure 87 (Disease Ontology:DOID:0070586)", "pathway": " (mmu:11434); (R-MMU-1300645)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "1783391;1939002;2111255;2127931;21750661;22362218;26264441", "class_list": "", "function": "ACR or PRSS21 or both may function cooperatively with SPAM1 in sperm/cumulus penetration, [RefSeq, PubMed]; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome., [UniProtKB]; SERPINA3K is involved in the Clock gene-mediated male fertility by regulating acrosin activity and provide the first evidence that SERPINA3K could be regulated by Clock gene via retinoic acid-related orphan receptor response elements., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.21.10", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0004040 amidase activity;GO:0005537 D-mannose binding;GO:0042806 fucose binding", "go_cellular_component": "GO:0005798 Golgi-associated vesicle;GO:0001669 acrosomal vesicle;GO:0043159 acrosomal matrix;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007190 activation of adenylate cyclase activity;GO:0007339 binding of sperm to zona pellucida;GO:0007338 single fertilization;GO:0007340 acrosome reaction;GO:0048545 response to steroid hormone", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P23578-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BH04-1", "uniprot_id": "PCKGM_MOUSE", "mass": 70528.0, "length": 640, "protein_name": "Phosphoenolpyruvate carboxykinase [GTP], mitochondrial", "gene_name": "Pck2", "organism": "Mouse", "refseq_name": "phosphoenolpyruvate carboxykinase [GTP], mitochondrial", "refseq_ac": "NP_083270", "gene_names_uniprotkb": "Pck2", "gene_names_refseq": "1810010O14Rik; 9130022B02Rik; PEPCK-M; Pck2", "protein_names_uniprotkb": "Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; 2.7.11.-; 4.1.1.32; PEPCK-M; Serine/threonine-protein kinase PCK2", "protein_names_refseq": "phosphoenolpyruvate carboxykinase [GTP], mitochondrial; phosphoenolpyruvate carboxylase; serine/threonine-protein kinase PCK2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74551); (R-MMU-70263)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "19635791;21183079;21750661;23806337;25605945;33147485;36845668;37828378;38934051;39337381", "class_list": "", "function": "DNA 5mC and RNA m[6]A Collaborate to Upregulate Phosphoenolpyruvate Carboxykinase 2 for Kupffer Cell Activation. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that PEPCK-M message and protein were detected in islets., [RefSeq, PubMed]; Mitochondrial phosphoenolpyruvate carboxykinase that catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Can play an active role in glyceroneogenesis and gluconeogenesis. Also acts as a serine/threonine-protein kinase: phosphorylates and activates ACSL4, thereby promoting ferroptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; PCK2 maintains intestinal homeostasis and prevents colitis by protecting antibody-secreting cells from oxidative stress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMM9;Q91Z10", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.-;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.11.8", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005525 GTP binding;GO:0030145 manganese ion binding;GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity;GO:0004611 phosphoenolpyruvate carboxykinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0042866 pyruvate biosynthetic process;GO:0046327 glycerol biosynthetic process from pyruvate;GO:0032024 positive regulation of insulin secretion;GO:0032869 cellular response to insulin stimulus;GO:0042594 response to starvation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BH04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLF6-1", "uniprot_id": "TGM1_MOUSE", "mass": 89826.0, "length": 815, "protein_name": "Protein-glutamine gamma-glutamyltransferase K", "gene_name": "Tgm1", "organism": "Mouse", "refseq_name": "protein-glutamine gamma-glutamyltransferase K", "refseq_ac": "NP_001155186", "gene_names_uniprotkb": "Tgm1", "gene_names_refseq": "2310004J08Rik; Tgase1; Tgm1", "protein_names_uniprotkb": "Protein-glutamine gamma-glutamyltransferase K; 2.3.2.13; Epidermal TGase; TG(K); TGK; TGase K; TGase-1; Transglutaminase K; Transglutaminase-1", "protein_names_refseq": "K polypeptide; TG(K); TGK; TGase K; TGase-1; epidermal TGase; protein-glutamine gamma-glutamyltransferase K; protein-glutamine-gamma-glutamyltransferase; transglutaminase K; transglutaminase type 1; transglutaminase-1", "tax_id": 10090, "disease": "autosomal recessive congenital ichthyosis 1 (Disease Ontology:DOID:0060656)", "pathway": " (mmu:21816); (R-MMU-6809371)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10567386;17242355;18630941;21183079;21750661;26495903;28011936;34428180;36064721;38071490", "class_list": "", "function": "Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Proteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0T9", "ec_number_list": "3.4.22.-;3.4.-.-;2.3.1.-;2.3.2.13;3.5.1.44", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003810 protein-glutamine gamma-glutamyltransferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016020 membrane", "go_biological_process": "GO:0030216 keratinocyte differentiation;GO:0009887 animal organ morphogenesis;GO:0018149 peptide cross-linking;GO:0045787 positive regulation of cell cycle;GO:0010838 positive regulation of keratinocyte proliferation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JLF6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESU6-1", "uniprot_id": "BRD4_MOUSE", "mass": 155895.0, "length": 1400, "protein_name": "Bromodomain-containing protein 4", "gene_name": "Brd4", "organism": "Mouse", "refseq_name": "bromodomain-containing protein 4 isoform 1", "refseq_ac": "NP_065254", "gene_names_uniprotkb": "Brd4; Mcap", "gene_names_refseq": "Brd4; Brd5; HUNK1; MCAP; WI-11513", "protein_names_uniprotkb": "Bromodomain-containing protein 4; MCAP; Mitotic chromosome-associated protein", "protein_names_refseq": "bromodomain-containing 5; bromodomain-containing protein 4 isoform 1; bromodomain-containing protein 4; fsh-like protein; mitotic chromosome-associated protein", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); Cornelia de Lange syndrome 6 (Disease Ontology:DOID:0060970); nephrocalcinosis (Disease Ontology:DOID:12679); melanoma (Disease Ontology:DOID:1909); colon cancer (Disease Ontology:DOID:219); transitional cell carcinoma (Disease Ontology:DOID:2671); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (mmu:57261)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10938129;11997514;12192049;12840145;16109376;17267518;19828451;20715035;21750661;21814200;21964340;22567088;23806337;28262505;28315936;29379197;31219806;40128797", "class_list": "", "function": "Brd4 binds to replication factor C and inhibits progression to S phase, [RefSeq, PubMed]; Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:10938129, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:10938129). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters. Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6. BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (By similarity). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (PubMed:28262505). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo. In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B. Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0V2V7;Q8VHF7;Q8VHF8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0005694 chromosome", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9ESU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BM65-1", "uniprot_id": "NYAP2_MOUSE", "mass": 73897.0, "length": 682, "protein_name": "Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2", "gene_name": "Nyap2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nyap2; 9430031J16Rik; Kiaa1486", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:241134)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18034455;21183079;21750661;21946561;22645316;24129315", "class_list": "", "function": "Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3Z7K6;Q641L6;Q6ZPP8;Q8BWV8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0048812 neuron projection morphogenesis;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BM65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P37242-1", "uniprot_id": "THB_MOUSE", "mass": 52630.0, "length": 461, "protein_name": "Thyroid hormone receptor beta", "gene_name": "Thrb", "organism": "Mouse", "refseq_name": "thyroid hormone receptor beta isoform 1", "refseq_ac": "NP_001106888", "gene_names_uniprotkb": "Thrb; Erba2; Nr1a2", "gene_names_refseq": "Nr1a2; T3R[b]; T3Rbeta; Thrb1; Thrb2; Thrb; c-erbAbeta", "protein_names_uniprotkb": "Thyroid hormone receptor beta; Nuclear receptor subfamily 1 group A member 2; c-erbA-2; c-erbA-beta", "protein_names_refseq": "TR beta; c-erbA-2; c-erbA-beta; nuclear receptor subfamily 1 group A member 2; thyroid hormone receptor beta isoform 1", "tax_id": 10090, "disease": "selective pituitary thyroid hormone resistance (Disease Ontology:DOID:0111374); prostate cancer (Disease Ontology:DOID:10283); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); thyroid hormone resistance syndrome (Disease Ontology:DOID:11633); breast cancer (Disease Ontology:DOID:1612); breast carcinoma (Disease Ontology:DOID:3459); follicular thyroid carcinoma (Disease Ontology:DOID:3962); renal cell carcinoma (Disease Ontology:DOID:4450); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (mmu:21834); (R-MMU-383280); (R-MMU-4090294)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "1944303;21750661;27254276;34428180;38609183;38757582;38889231;7708051;9405624", "class_list": "", "function": "Canonical and Noncanonical Contribution of Thyroid Hormone Receptor Isoforms Alpha and Beta to Cardiac Hypertrophy and Heart Rate in Male Mice., [RefSeq, PubMed]; Comparative Phenotyping of Mice Reveals Canonical and Noncanonical Physiological Functions of TRalpha and TRbeta., [RefSeq, PubMed]; Nr1h4 and Thrb ameliorate ER stress and provide protection in the MPTP mouse model of Parkinson's. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P37244;Q0VDR8;Q3TY80", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0007621 negative regulation of female receptivity;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P37242-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB50-1", "uniprot_id": "AP1S2_MOUSE", "mass": 18929.0, "length": 160, "protein_name": "AP-1 complex subunit sigma-2", "gene_name": "Ap1s2", "organism": "Mouse", "refseq_name": "AP-1 complex subunit sigma-2 isoform 2", "refseq_ac": "NP_001277307", "gene_names_uniprotkb": "Ap1s2", "gene_names_refseq": "1500012A13Rik; Ap1s2; EST1", "protein_names_uniprotkb": "AP-1 complex subunit sigma-2; Adaptor protein complex AP-1 subunit sigma-1B; Adaptor-related protein complex 1 subunit sigma-1B; Clathrin assembly protein complex 1 sigma-1B small chain; Golgi adaptor HA1/AP1 adaptin sigma-1B subunit; Sigma 1B subunit of AP-1 clathrin; Sigma-adaptin 1B; Sigma1B-adaptin", "protein_names_refseq": "AP-1 complex subunit sigma-2 isoform 2; AP-1 complex subunit sigma-2; adapter-related protein complex 1 sigma-1B subunit; adaptor protein complex AP-1 sigma-1B subunit; adaptor-related protein complex 1 subunit sigma-1B; clathrin assembly protein complex 1 sigma-1B small chain; golgi adaptor HA1/AP1 adaptin sigma-1B subunit; sigma 1B subunit of AP-1 clathrin", "tax_id": 10090, "disease": "syndromic X-linked intellectual disability 5 (Disease Ontology:DOID:0060800)", "pathway": " (mmu:108012); (R-MMU-2132295); (R-MMU-432720); (R-MMU-432722)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "20203623;21750661", "class_list": "", "function": "Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity)., [UniProtKB]; Synaptic vesicle reformation in cultured neurons from adaptor protein complex AP-1 sigma-1B-deficient mice is reduced upon stimulation, and large endosomal intermediates accumulate. Erratum:[EMBO J. 2010 Jun 2;29(11):1941. Boning, Daniel [corrected to Boening, Daniel]], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1B0F4;Q543R7", "ec_number_list": "", "go_molecular_function": "GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005905 clathrin-coated pit;GO:0032588 trans-Golgi network membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:1903232 melanosome assembly;GO:0006886 intracellular protein transport;GO:0008542 visual learning;GO:0050885 neuromuscular process controlling balance;GO:0060612 adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DB50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8S4-1", "uniprot_id": "ORN_MOUSE", "mass": 26739.0, "length": 237, "protein_name": "Oligoribonuclease, mitochondrial", "gene_name": "Rexo2", "organism": "Mouse", "refseq_name": "oligoribonuclease, mitochondrial isoform 1 precursor", "refseq_ac": "NP_077195", "gene_names_uniprotkb": "Rexo2; Smfn", "gene_names_refseq": "1810038D15Rik; Rex2; Rexo2; Sfn; Smfn", "protein_names_uniprotkb": "Oligoribonuclease, mitochondrial; 3.1.15.-; RNA exonuclease 2 homolog; Small fragment nuclease", "protein_names_refseq": "REX2, RNA exonuclease 2 homolog; oligoribonuclease, mitochondrial isoform 1 precursor; oligoribonuclease, mitochondrial; small fragment nuclease", "tax_id": 10090, "disease": "", "pathway": " (mmu:104444)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;23576753;28135057;28528544;31588022;37828378", "class_list": "", "function": "3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (PubMed:31588022). Binds and degrades longer oligonucleotides with a lower affinity (By similarity). Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (By similarity). Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (PubMed:31588022). Essential for embryonic development (PubMed:31588022)., [UniProtKB, UniProtKB, PubMed]; Efficient RNA turnover by REXO2 is thus required to maintain promoter specificity and proper regulation of transcription in mammalian mitochondria., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0000287 magnesium ion binding;GO:0003676 nucleic acid binding;GO:0008408 3'-5' exonuclease activity;GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0006139 nucleobase-containing compound metabolic process;GO:2000827 mitochondrial RNA surveillance", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D8S4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFW1-1", "uniprot_id": "ANO2_MOUSE", "mass": 114134.0, "length": 1002, "protein_name": "Anoctamin-2", "gene_name": "Ano2", "organism": "Mouse", "refseq_name": "anoctamin-2 isoform 1", "refseq_ac": "NP_705817", "gene_names_uniprotkb": "Ano2; Tmem16b", "gene_names_refseq": "Ano2; Tmem16b", "protein_names_uniprotkb": "Anoctamin-2; Transmembrane protein 16B", "protein_names_refseq": "anoctamin-2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:243634); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "18729231;19474308;19475416;19561302;20056604;21750661;22075693;23576756;36744918", "class_list": "", "function": "ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification. GeneRIF: Ano2 likely amplifies the odor-induced generator potential in olfactory sensory neuron cilia by sensing elevated calcium levels, permitting the outward flow of chloride ions from the cell., [RefSeq, PubMed]; Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Data show the expression of Tmem16b during murine embryogenesis with an emphasis on the respiratory, digestive, skeletal, and integumentary systems., [RefSeq, PubMed]; Our results demonstrate that mTMEM16B functions as a Ca(2+)-activated Cl(-) channel when expressed in HEK 293T cells., [RefSeq, PubMed]; Paradoxical electro-olfactogram responses in TMEM16B knock-out mice., [RefSeq, PubMed]; TMEM16B is lost from photoreceptor membranes of MPP4-deficient mice, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "C4N788;Q8C8N6", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0034707 chloride channel complex;GO:0097730 non-motile cilium", "go_biological_process": "GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CFW1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15806-1", "uniprot_id": "TFE2_MOUSE", "mass": 67701.0, "length": 651, "protein_name": "Transcription factor E2-alpha", "gene_name": "Tcf3", "organism": "Mouse", "refseq_name": "transcription factor E2-alpha isoform 2", "refseq_ac": "NP_001157620", "gene_names_uniprotkb": "Tcf3; Alf2; Me2; Tcfe2a", "gene_names_refseq": "A1; ALF2; E12/E47; E12; E2A; E47; KA1; ME2; Pan1; Pan2; TCF-3; Tcf3; Tcfe2a; VDIR; bHLHb21", "protein_names_uniprotkb": "Transcription factor E2-alpha; Immunoglobulin enhancer-binding factor E12/E47; TCF-3; Transcription factor 3; Transcription factor A1", "protein_names_refseq": "immunoglobulin enhancer-binding factor E12/E47; transcription factor A1; transcription factor E2-alpha isoform 2; transcription factor E2-alpha; transcription factor E2a", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); Pitt-Hopkins syndrome (Disease Ontology:DOID:0060488); agammaglobulinemia 8A (Disease Ontology:DOID:0081140); agammaglobulinemia 8B (Disease Ontology:DOID:0081143); prostate cancer (Disease Ontology:DOID:10283); colorectal cancer (Disease Ontology:DOID:9256); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:21423)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "11309385;11318877;12196028;12200424;14592976;15226298;16291758;16407974;18069799;18214987;21183079;21750661;2181401;23395635;23938248;24129315;30426815;37684687;38839978;7589808;7875598;8112613;9409784", "class_list": "", "function": "Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon. Publication Status: Online-Only, [RefSeq, PubMed]; Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity., [UniProtKB, UniProtKB]; Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators., [RefSeq, PubMed]; Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (PubMed:15226298, PubMed:18214987). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (PubMed:18214987). Together with TCF15, required for the mesenchymal to epithelial transition (PubMed:11309385, PubMed:15226298). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (PubMed:15226298, PubMed:18214987, PubMed:30426815). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (By similarity). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (PubMed:2181401)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U153;Q8CAH9;Q8VCY4;Q922S2;Q99MB8;Q9CYJ4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P15806-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VI59-1", "uniprot_id": "PCX3_MOUSE", "mass": 221573.0, "length": 2028, "protein_name": "Pecanex-like protein 3", "gene_name": "Pcnx3", "organism": "Mouse", "refseq_name": "pecanex-like protein 3", "refseq_ac": "NP_659117", "gene_names_uniprotkb": "Pcnx3; Pcnxl3", "gene_names_refseq": "Pcnx3; Pcnxl3; mKIAA4073", "protein_names_uniprotkb": "Pecanex-like protein 3; Pecanex homolog protein 3", "protein_names_refseq": "pecanex homolog protein 3; pecanex-like 3; pecanex-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:104401)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10894943;19144319;21183079;21750661;25428506;26495903;30084848;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VI59-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923W9-1", "uniprot_id": "ADA33_MOUSE", "mass": 86971.0, "length": 797, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 33", "gene_name": "Adam33", "organism": "Mouse", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 33 isoform 1 preproprotein", "refseq_ac": "NP_291093", "gene_names_uniprotkb": "Adam33", "gene_names_refseq": "Adam33; Adaml", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 33; 3.4.24.-; ADAM 33", "protein_names_refseq": "a disintegrin and metalloprotease domain 33; disintegrin and metalloproteinase domain-containing protein 33 isoform 1 preproprotein; disintegrin and metalloproteinase domain-containing protein 33", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rhinitis (Disease Ontology:DOID:4483)", "pathway": " (mmu:110751); (R-MMU-9762292)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11814695;11897009;16943435;19665773;21750661;25428506", "class_list": "", "function": "ADAM33 is not essential for growth or reproduction in the mouse and does not modulate baseline or allergen-induced airway responsiveness., [RefSeq, PubMed]; Adam33/Adam33 shows 2 significant increments in expression during lung morphogenesis, suggesting important developmental regulation., [RefSeq, PubMed]; Identification and preliminary characterization of mouse Adam33., [RefSeq, PubMed]; Metalloprotease that cleaves and sheds the ectodomains of cell-surface proteins and thereby contributes to angiogenesis, cell differentiation, inflammation, and cell proliferation. Modulates the activity of adhesion molecules and cytokines by generating soluble forms, leading to either attenuation of cell-surface signaling or initiation of downstream intracellular signaling pathways. For instance, acts as a constitutive sheddase of kit ligand/KITLG. Promotes and maintains a proliferative phenotype in vascular smooth muscle cells through regulation of the PI3K/AKT and ERK signaling pathways. Additionally, enhances cell migration and regulates cytokine secretion during airway vascular remodeling via the same signaling cascades., [UniProtKB, UniProtKB]; The mouse and human predicted proteins consisted of 797 and 813 amino acids, respectively, and they shared 70% homology of the entire amino acid sequence., [RefSeq, PubMed]; This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is widely expressed, most highly in the adult brain, heart, kidney, lung and testis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8R5G5", "ec_number_list": "3.4.24.-", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0042127 regulation of cell population proliferation;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q923W9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04760-1", "uniprot_id": "ACHG_MOUSE", "mass": 58745.0, "length": 519, "protein_name": "Acetylcholine receptor subunit gamma", "gene_name": "Chrng", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Chrng; Acrg", "gene_names_refseq": "", "protein_names_uniprotkb": "Acetylcholine receptor subunit gamma", "protein_names_refseq": "", "tax_id": 10090, "disease": "contractures, pterygia, and spondylocarpotarsal fusion syndrome (Disease Ontology:DOID:0080110)", "pathway": " (R-MMU-629587)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;3010242;3244354;3480767;3755765;7708706", "class_list": "", "function": "After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0042391 regulation of membrane potential;GO:0095500 acetylcholine receptor signaling pathway;GO:0007268 chemical synaptic transmission;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P04760-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51827-1", "uniprot_id": "AFF3_MOUSE", "mass": 136131.0, "length": 1254, "protein_name": "AF4/FMR2 family member 3", "gene_name": "Aff3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Aff3; Laf4", "gene_names_refseq": "", "protein_names_uniprotkb": "AF4/FMR2 family member 3; Lymphoid nuclear protein related to AF4; Protein LAF-4", "protein_names_refseq": "", "tax_id": 10090, "disease": "KINSSHIP syndrome (Disease Ontology:DOID:0112383); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:16764)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;8555498", "class_list": "", "function": "Putative transcription activator that may function in lymphoid development and oncogenesis., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 9890, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q80WS6", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0032783 super elongation complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0034612 response to tumor necrosis factor;GO:0006355 regulation of DNA-templated transcription;GO:0050877 nervous system process;GO:0035116 embryonic hindlimb morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P51827-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2U2-1", "uniprot_id": "ALKB6_MOUSE", "mass": 26776.0, "length": 238, "protein_name": "Probable RNA/DNA demethylase ALKBH6", "gene_name": "Alkbh6", "organism": "Mouse", "refseq_name": "probable RNA/DNA demethylase ALKBH6", "refseq_ac": "NP_932144", "gene_names_uniprotkb": "Alkbh6", "gene_names_refseq": "Abh6; Alkbh6; C130099A02", "protein_names_uniprotkb": "Probable RNA/DNA demethylase ALKBH6; 1.14.11.-; Alkylated DNA repair protein alkB homolog 6; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6", "protein_names_refseq": "alkB, alkylation repair homolog 6; alkylated DNA repair protein alkB homolog 6; alpha-ketoglutarate-dependent dioxygenase alkB homolog 6; probable RNA/DNA demethylase ALKBH6; probable alpha-ketoglutarate-dependent dioxygenase ABH6", "tax_id": 10090, "disease": "", "pathway": " (mmu:233065)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "Probable Fe(2+)/2-oxoglutarate-dependent dioxygenase involved in oxidative demethylation of nucleic acids. Binds nucleic acids with a preference for ssDNA or ssRNA to other types of DNAs. May play a role in nucleic acid damage repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X994", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity;GO:0051213 dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005925 focal adhesion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K2U2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z248-1", "uniprot_id": "AEBP2_MOUSE", "mass": 52963.0, "length": 504, "protein_name": "Zinc finger protein AEBP2", "gene_name": "Aebp2", "organism": "Mouse", "refseq_name": "zinc finger protein AEBP2 isoform 1", "refseq_ac": "NP_001005605", "gene_names_uniprotkb": "Aebp2", "gene_names_refseq": "Aebp2; B230313N05Rik", "protein_names_uniprotkb": "Zinc finger protein AEBP2; AE-binding protein 2; Adipocyte enhancer-binding protein 2", "protein_names_refseq": "adipocyte enhancer-binding protein 2; zinc finger protein AEBP2 isoform 1; zinc finger protein AEBP2", "tax_id": 10090, "disease": "Hirschsprung's disease (Disease Ontology:DOID:10487); Waardenburg syndrome (Disease Ontology:DOID:9258)", "pathway": " (mmu:11569); (R-MMU-212300); (R-MMU-3214841)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10329662;17242355;19026780;19293275;20144788;21183079;21750661;25428506", "class_list": "", "function": "A large fraction of AEBP2's target loci also map closely to the known target loci of the Polycomb Repression Complex PRC2., [RefSeq, PubMed]; Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene. Plays a role in nucleosome localization of the PRC2 complex., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PF91;Q78HB0;Q8BGV1;Q8CE51", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035098 ESC/E(Z) complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z248-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C1A9-1", "uniprot_id": "ABD18_MOUSE", "mass": 53168.0, "length": 464, "protein_name": "Cardiolipin-specific deacylase, mitochondrial", "gene_name": "Abhd18", "organism": "Mouse", "refseq_name": "protein ABHD18 isoform a precursor", "refseq_ac": "NP_080898", "gene_names_uniprotkb": "Abhd18", "gene_names_refseq": "2310068E01Rik; 3110057O12Rik; Abhd18", "protein_names_uniprotkb": "Cardiolipin-specific deacylase, mitochondrial; Abhydrolase domain-containing protein 18; Alpha/beta hydrolase domain-containing protein 18", "protein_names_refseq": "abhydrolase domain-containing protein 18; alpha/beta hydrolase domain-containing protein 18; protein ABHD18 isoform a precursor; protein ABHD18", "tax_id": 10090, "disease": "", "pathway": " (mmu:269423)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;34428180;40378955;40903572", "class_list": "", "function": "Catalyzes the hydrolysis of an acyl chain from the tetra-acylated cardiolipin (CL) and produces the tri-acylated monolysocardiolipin (MLCL). Prefers CL with shorter and saturated fatty acyl chains as substrates. Together with Tafazzin (TAZ), it participates in the mechanism of CL remodeling, a process consisting of repetitive cycles of hydrolysis and reacylation of the fatty acids that make up CL, where the nascent acyl chains are replaced with longer, unsaturated chains., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQS7;Q562E0;Q8C0I3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8C1A9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61407-1", "uniprot_id": "TDRD6_MOUSE", "mass": 237914.0, "length": 2134, "protein_name": "Tudor domain-containing protein 6", "gene_name": "Tdrd6", "organism": "Mouse", "refseq_name": "tudor domain-containing protein 6 isoform 2", "refseq_ac": "NP_940810", "gene_names_uniprotkb": "Tdrd6", "gene_names_refseq": "Tdr2; Tdrd6", "protein_names_uniprotkb": "Tudor domain-containing protein 6", "protein_names_refseq": "tudor domain-containing protein 6 isoform 2; tudor domain-containing protein 6; tudor repeat 2 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:210510)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17141210;19345099;19584108;19926723;21183079;21750661;27149095;28254886;28263986;35820727;38341271", "class_list": "", "function": "Bi-allelic variants in chromatoid body protein TDRD6 cause spermiogenesis defects and severe oligoasthenoteratozoospermia in humans. Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that Tdrd6 is essential for spermiogenesis, for chromatoid body structure, and for proper mature and precursor miRNA expression., [RefSeq, PubMed]; Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon fertilization), and for proper miRNA expression and spliceosome maturation (By similarity) (PubMed:19345099, PubMed:27149095, PubMed:28263986). Essential for RNA-dependent helicase UPF1 localization to chromatoid body, for UPF1-UPF2 and UPF1-DDX4 interactions which are required for mRNA degradation, using the extended 3' UTR-triggered nonsense-mediated mRNA decay (NMD) pathway (PubMed:27149095). Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through interaction with arginine N-methyltransferase PRMT5 and symmetrically arginine dimethylated SNRPB (small nuclear ribonucleoprotein-associated protein) (PubMed:28263986)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Tudor-related proteins, which contain multiple repeats of the Tudor domain, constitute an evolutionarily conserved class of nuage components in the germ-line, and their localization or accumulation to nuage is likely conferred by a Tudor domain structure, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0030719 P granule organization;GO:0007283 spermatogenesis;GO:0007281 germ cell development;GO:0000387 spliceosomal snRNP assembly;GO:0034587 piRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P61407-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K268-1", "uniprot_id": "ABCF3_MOUSE", "mass": 79865.0, "length": 709, "protein_name": "ATP-binding cassette sub-family F member 3", "gene_name": "Abcf3", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family F member 3", "refseq_ac": "NP_038880", "gene_names_uniprotkb": "Abcf3", "gene_names_refseq": "Abcf3", "protein_names_uniprotkb": "ATP-binding cassette sub-family F member 3", "protein_names_refseq": "ATP-binding cassette sub-family F member 3; ATP-binding cassette, sub-family F (GCN20), member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:27406)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10708515;20173027;21750661;22623793;31219806;31413116;33300544;34428180", "class_list": "", "function": "Characterization of ABCF3 protein and its interaction with OAS1B, [RefSeq, PubMed]; Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JL49", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "", "go_biological_process": "GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8K268-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01755-1", "uniprot_id": "TCP11_MOUSE", "mass": 61970.0, "length": 566, "protein_name": "T-complex protein 11", "gene_name": "Tcp11", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tcp11; Tcp-11", "gene_names_refseq": "", "protein_names_uniprotkb": "T-complex protein 11; Testis-specific protein PBS13", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "1893875;21750661;27105888;31219806;9322250;9820206", "class_list": "", "function": "Plays a role in the process of sperm capacitation and acrosome reactions (PubMed:9322250, PubMed:9820206). Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway (PubMed:9322250, PubMed:9820206)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum;GO:0097225 sperm midpiece", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0045920 negative regulation of exocytosis;GO:1902490 regulation of sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q01755-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03157-1", "uniprot_id": "APLP1_MOUSE", "mass": 72848.0, "length": 654, "protein_name": "Amyloid beta precursor like protein 1", "gene_name": "Aplp1", "organism": "Mouse", "refseq_name": "amyloid beta precursor like protein 1 precursor", "refseq_ac": "NP_031493", "gene_names_uniprotkb": "Aplp1", "gene_names_refseq": "Aplp1", "protein_names_uniprotkb": "Amyloid beta precursor like protein 1; APLP-1; APLP; Amyloid beta (A4) precursor-like protein 1; Amyloid-like protein 1", "protein_names_refseq": "APLP-1; APLP; amyloid beta (A4) precursor-like protein 1; amyloid beta precursor like protein 1 precursor; amyloid-like protein 1", "tax_id": 10090, "disease": "Alzheimer's disease 1 (Disease Ontology:DOID:0080348); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:11803)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10460257;11247302;11517249;12228233;1279693;12826668;16314516;22645316;31599954;34172566;8576160", "class_list": "", "function": "May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I., [UniProtKB]; Mechanistic basis for receptor-mediated pathological alpha-synuclein fibril cell-to-cell transmission in Parkinson's disease., [RefSeq, PubMed]; The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IZZ1;Q3U311;Q8VC38", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0046914 transition metal ion binding;GO:0031694 alpha-2A adrenergic receptor binding;GO:0031696 alpha-2C adrenergic receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006417 regulation of translation;GO:0006897 endocytosis;GO:0007155 cell adhesion;GO:0007409 axonogenesis;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q03157-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2APF3-1", "uniprot_id": "CTCFL_MOUSE", "mass": 73108.0, "length": 636, "protein_name": "Transcriptional repressor CTCFL", "gene_name": "Ctcfl", "organism": "Mouse", "refseq_name": "transcriptional repressor CTCFL isoform 2", "refseq_ac": "NP_001074856", "gene_names_uniprotkb": "Ctcfl; Boris", "gene_names_refseq": "Boris; Ctcfl", "protein_names_uniprotkb": "Transcriptional repressor CTCFL; Brother of the regulator of imprinted sites; CCCTC-binding factor; CTCF paralog; CTCF-like protein", "protein_names_refseq": "BORIS; Brother of the regulator of imprinted sites; CCCTC-binding factor (zinc finger protein)-like; CTCF paralog; CTCF-like protein; Transcriptional repressor CTCFL; likely orthologue of H. sapiens CCCTC-binding factor-like protein (CTCFL); transcriptional repressor CTCFL isoform 2", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 21 (Disease Ontology:DOID:0070051)", "pathway": " (mmu:664799)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12011441;17048991;18632606;19029807;28145452;32393311;33756271;34158481;36692143", "class_list": "", "function": "Boris knockout eliminates AOM/DSS-induced in situ colorectal cancer by suppressing DNA damage repair and inflammation., [RefSeq, PubMed]; CTCF and BORIS cooperate with additional Testis-specific transcriptional regulators to regulate gene expression in developing male gametes. Erratum:[Sci Rep. 2017 Aug 04;7:46891. doi: 10.1038/srep46891. PMID: 28776597] Publication Status: Online-Only, [RefSeq, PubMed]; CTCFL and PRMT7 may play a role in male germline imprinted gene methylation., [RefSeq, PubMed]; CTCFL expression is associated with cerebral vascular abnormalities., [RefSeq, PubMed]; CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region, [RefSeq, PubMed]; DNA damage-induced and ATR/Rfx1-mediated increase of miR-709 expression in exposed testes may be a protective mechanism that effectively decreases a cellular level of BORIS to prevent massive aberrant erasure of DNA methylation after radiation exposure., [RefSeq, PubMed]; Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation. Erratum:[Genome Biol. 2020 Jun 2;21(1):133. doi: 10.1186/s13059-020-02056-6. PMID: 32487268] Publication Status: Online-Only, [RefSeq, PubMed]; Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters., [UniProtKB, PubMed]; The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EKP6;Q3Y6S0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0045815 transcription initiation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A2APF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35668-1", "uniprot_id": "HAP1_MOUSE", "mass": 70116.0, "length": 628, "protein_name": "Huntingtin-associated protein 1", "gene_name": "Hap1", "organism": "Mouse", "refseq_name": "huntingtin-associated protein 1 isoform A", "refseq_ac": "NP_034534", "gene_names_uniprotkb": "Hap1", "gene_names_refseq": "HAP-1; Hap1", "protein_names_uniprotkb": "Huntingtin-associated protein 1; HAP-1", "protein_names_refseq": "huntingtin-associated protein 1 isoform A", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 68 (Disease Ontology:DOID:0112204); Huntington's disease (Disease Ontology:DOID:12858); melancholic depression (Disease Ontology:DOID:1595)", "pathway": " (mmu:15114)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12890790;15379999;17868456;18636121;21750661;21985783;23532844;23658157;24355921;24366265;24453320;31219806;32876919;33060070;36251080;40885482;9599014;9657855", "class_list": "", "function": "Dexamethasone Protects Against Ischaemic Brain Injury via Inhibiting the pAkt Signalling Pathway Through Increasing Hap1., [RefSeq, PubMed]; Differential expression and roles of Huntingtin and Huntingtin-associated protein 1 in the mouse and primate brains. Publication Status: Online-Only, [RefSeq, PubMed]; Hap1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice., [RefSeq, PubMed]; Huntingtin-associated protein 1 plays an essential role in the pathogenesis of type 2 diabetes by regulating the translocation of GLUT4 in mouse adipocytes., [RefSeq, PubMed]; Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to facilitate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB regulating the number of Npyr1-expressing cells), and ITPR1/InsP3R1-mediated Ca(2+) release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesiss; however, reports are conflicting: PubMed:21985783 reports that Hap1 is required for ciliogenesis in primary cortical neurons and proposes that HTT interacts with PCM1 through HAP1; PubMed:23532844 reports that mice with disrupted Hap1 display normal cilium formation and function. Involved in regulation of exocytosis. Isoform A but not isoform B seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs; sequestration is enhanced by an expanded polyglutamine repeat within TBP., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene was first identified as a neuronal protein that binds the HD protein huntingtin. The protein also interacts with kinesin light chain, 14-3-3 proteins, and Abelson helper integration site 1 protein. The protein is involved in intracellular trafficking of vesicles and organelles, and lack of the protein results in neuronal death resembling the hypothalamic degeneration that occurs in Huntington's disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35636", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0044325 transmembrane transporter binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005769 early endosome", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:0010976 positive regulation of neuron projection development;GO:0015031 protein transport;GO:0031175 neuron projection development;GO:0006605 protein targeting", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O35668-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C165-1", "uniprot_id": "P20D1_MOUSE", "mass": 55663.0, "length": 503, "protein_name": "N-fatty-acyl-amino acid synthase/hydrolase PM20D1", "gene_name": "Pm20d1", "organism": "Mouse", "refseq_name": "N-fatty-acyl-amino acid synthase/hydrolase PM20D1 precursor", "refseq_ac": "NP_835180", "gene_names_uniprotkb": "Pm20d1", "gene_names_refseq": "4732466D17Rik; Pm20d1", "protein_names_uniprotkb": "N-fatty-acyl-amino acid synthase/hydrolase PM20D1; 3.5.1.114; 3.5.1.14; PM20D1; Peptidase M20 domain-containing protein 1", "protein_names_refseq": "N-fatty-acyl-amino acid synthase/hydrolase PM20D1 precursor; N-fatty-acyl-amino acid synthase/hydrolase PM20D1; peptidase M20 domain-containing protein 1; probable carboxypeptidase PM20D1", "tax_id": 10090, "disease": "", "pathway": " (mmu:212933); (R-MMU-9673163)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;27374330;29533650;29967167;30899004;31568785;31659023;32271712;32402239;34428180;34673451;40997131", "class_list": "", "function": "Inhibition of miR-324-5p increases PM20D1-mediated white and brown adipose loss and reduces body weight in juvenile mice, [RefSeq, PubMed]; Kir6.2 is essential to maintain neurite features by modulating PM20D1-reduced mitochondrial ATP generation., [RefSeq, PubMed]; Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction (Probable) (PubMed:27374330, PubMed:29533650, PubMed:29967167, PubMed:32271712, PubMed:32402239). Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure (PubMed:27374330, PubMed:29967167, PubMed:32271712). PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles (PubMed:32402239)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Study demonstrates that PM20D1 is a bidirectional enzyme in vitro, catalyzing both the condensation of fatty acids and amino acids to generate N-acyl amino acids and also the reverse hydrolytic reaction. N-acyl amino acids directly bind mitochondria and function as endogenous uncouplers of UCP1-independent respiration., [RefSeq, PubMed]; These data demonstrate that PM20D1 is a dominant enzymatic regulator of NAA levels in vivo and elucidate physiologic functions for NAA signaling in metabolism and nociception., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNX0;Q8R117", "ec_number_list": "3.5.1.99;3.1.1.-;3.5.1.114;3.5.1.14", "go_molecular_function": "GO:0004046 aminoacylase activity;GO:0046872 metal ion binding;GO:0008233 peptidase activity;GO:0016829 lyase activity;GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0006629 lipid metabolic process;GO:0006631 fatty acid metabolic process;GO:0097009 energy homeostasis;GO:0006520 amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q8C165-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3V4-1", "uniprot_id": "PADI6_MOUSE", "mass": 76778.0, "length": 682, "protein_name": "Inactive protein-arginine deiminase type-6", "gene_name": "Padi6", "organism": "Mouse", "refseq_name": "inactive protein-arginine deiminase type-6", "refseq_ac": "NP_694746", "gene_names_uniprotkb": "Padi6; Pad6; Padi5", "gene_names_refseq": "P75; Pad6; Padi5; Padi6; ePAD", "protein_names_uniprotkb": "Inactive protein-arginine deiminase type-6; Arginine deiminase-like protein; Egg and embryo abundant PAD; P75; Peptidylarginine deiminase VI; Protein-arginine deiminase type VI; Protein-arginine deiminase type-6; ePAD", "protein_names_refseq": "arginine deiminase-like protein; egg and embryo abundant PAD; inactive protein-arginine deiminase type-6; peptidyl arginine deiminase, egg and embryo abundant; peptidylarginine deiminase VI; protein-arginine deiminase type VI; protein-arginine deiminase type-6", "tax_id": 10090, "disease": "", "pathway": " (mmu:242726); (R-MMU-3247509)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12654293;15087120;16137333;17587491;18599511;21147087;21750661;27929740;37922900;38453481", "class_list": "", "function": "A maternal-effect Padi6 variant causes nuclear and cytoplasmic abnormalities in oocytes, as well as failure of epigenetic reprogramming and zygotic genome activation in embryos. Publication Status: Online-Only, [RefSeq, PubMed]; Inactivation of the PAD6 gene in mice leads to female infertility whereas male fertility is not affected., [RefSeq, PubMed]; Localized to egg cytoplasmic sheets; possible role for ePAD in cytoskeletal reorganization in the egg and early embryo, [RefSeq, PubMed]; Structural constituent of cytoplasmic lattices, which plays a key role in early embryonic development (PubMed:16137333, PubMed:17587491, PubMed:18599511, PubMed:27929740, PubMed:37922900). Cytoplasmic lattices consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (PubMed:37922900). They are required to store maternal proteins critical for embryonic development, such as ribosomal proteins and proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation (PubMed:18599511, PubMed:37922900, PubMed:38453481). In contrast to other members of the family, does not show protein-arginine deiminase activity due to its inability to bind Ca(2+) (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q75WC6", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0015631 tubulin binding;GO:0140094 structural constituent of cytoplasmic lattice;GO:0004668 protein-arginine deiminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045111 intermediate filament cytoskeleton;GO:0060473 cortical granule;GO:1990917 ooplasm", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007010 cytoskeleton organization;GO:0040016 embryonic cleavage;GO:0008104 intracellular protein localization;GO:0007028 cytoplasm organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K3V4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48725-1", "uniprot_id": "PCNT_MOUSE", "mass": 329465.0, "length": 2898, "protein_name": "Pericentrin", "gene_name": "Pcnt", "organism": "Mouse", "refseq_name": "pericentrin isoform b", "refseq_ac": "NP_001269921", "gene_names_uniprotkb": "Pcnt; Pcnt2", "gene_names_refseq": "KEN; Pcnt2; Pcnt; kendrin; m239Asp; m275Asp", "protein_names_uniprotkb": "Pericentrin", "protein_names_refseq": "pericentrin 2; pericentrin isoform b; pericentrin-250; pericentrin-360", "tax_id": 10090, "disease": "microcephalic osteodysplastic primordial dwarfism type II (Disease Ontology:DOID:0060609); Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (mmu:18541); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518); (R-MMU-9646399)", "pathway_count": 9, "publication_count": 8, "publication_id_list": "17084386;17626165;19144319;20471352;21183079;21750661;25428506;8124707", "class_list": "", "function": "Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0JBT0;A0JBT1", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005929 cilium;GO:0031514 motile cilium", "go_biological_process": "GO:0021696 cerebellar cortex morphogenesis;GO:0001701 in utero embryonic development;GO:0007165 signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0090316 positive regulation of intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P48725-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIN4-1", "uniprot_id": "PAK2_MOUSE", "mass": 57930.0, "length": 524, "protein_name": "Serine/threonine-protein kinase PAK 2", "gene_name": "Pak2", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase PAK 2", "refseq_ac": "NP_796300", "gene_names_uniprotkb": "Pak2", "gene_names_refseq": "5330420P17Rik; A130002K10Rik; D16Ertd269e; PAK-2; Pak2; mKIAA4182", "protein_names_uniprotkb": "Serine/threonine-protein kinase PAK 2; 2.7.11.1; Gamma-PAK; PAK-2; p21-activated kinase 2", "protein_names_refseq": "gamma-PAK; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; serine/threonine-protein kinase PAK 2", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); ductal carcinoma in situ (Disease Ontology:DOID:0060074); ureteral obstruction (Disease Ontology:DOID:5199)", "pathway": " (mmu:224105); (R-MMU-202433); (R-MMU-2871796); (R-MMU-389359); (R-MMU-3928664); (R-MMU-399954); (R-MMU-4420097); (R-MMU-445355); (R-MMU-5218920); (R-MMU-5621575); (R-MMU-5627123); (R-MMU-5687128); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013407); (R-MMU-9013408); (R-MMU-9013420); (R-MMU-9013423); (R-MMU-9013424)", "pathway_count": 20, "publication_count": 22, "publication_id_list": "11278362;11782491;12853446;14749374;17242355;18716323;19131326;21183079;23806337;26412398;26740625;31141452;31219806;32152506;33539470;34428180;35820727;36288343;36504449;36813765;37507081;38079473", "class_list": "", "function": "Loss-of-Function of p21-Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects., [RefSeq, PubMed]; PAK2 is essential for chromosome alignment in metaphase I oocytes. Publication Status: Online-Only, [RefSeq, PubMed]; PAK2 is necessary for myelination in the peripheral nervous system., [RefSeq, PubMed]; Phosphorylation of merlin at serine 518 is induced by the p21-activated kinase PAK2, [RefSeq, PubMed]; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:11278362). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (By similarity). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (By similarity). Full-length PAK2 stimulates cell survival and cell growth (By similarity). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (By similarity). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (By similarity). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:11278362). Phosphorylates CASP7, thereby preventing its activity (By similarity). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (By similarity). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (By similarity). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.1.1.13;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;3.6.5.-;2.7.11.26;2.7.11.19;2.7.11.17;3.6.5.2;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.10.1;2.7.10.4;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.3.1.168;2.7.11.39;3.4.19.12;2.3.1.-;3.1.4.4;3.6.4.6;2.7.11.31;1.6.3.-;3.1.4.11;2.3.2.27;2.7.11.18;2.3.1.48;4.1.1.32;1.16.1.-;2.7.11.38;3.6.1.-;3.6.-.-;2.1.2.1;2.3.2.26;7.1.1.2;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0150105 protein localization to cell-cell junction;GO:0006468 protein phosphorylation;GO:0016477 cell migration;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q8CIN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUL5-1", "uniprot_id": "PD1L2_MOUSE", "mass": 27820.0, "length": 247, "protein_name": "Programmed cell death 1 ligand 2", "gene_name": "Pdcd1lg2", "organism": "Mouse", "refseq_name": "programmed cell death 1 ligand 2 precursor", "refseq_ac": "NP_067371", "gene_names_uniprotkb": "Pdcd1lg2; B7dc; Btdc; Cd273; Pdl2", "gene_names_refseq": "B7-DC; Btdc; F730015O22Rik; PD-L2; Pdcd1lg2", "protein_names_uniprotkb": "Programmed cell death 1 ligand 2; B7-DC; Butyrophilin B7-DC; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; Programmed death ligand 2", "protein_names_refseq": "PD-1 ligand 2; PDCD1 ligand 2; butyrophilin B7-DC; butyrophilin-like protein; programmed cell death 1 ligand 2 precursor; programmed death ligand 2", "tax_id": 10090, "disease": "pulmonary tuberculosis (Disease Ontology:DOID:2957)", "pathway": " (mmu:58205); (R-MMU-389948); (R-MMU-9931295)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11224527;11283156;12161284;12421930;12444166;12719480;18641123;37006239;38622764", "class_list": "", "function": "B7-DC expression is inducible on macrophages and dendritic cells upon stimulation with IFN-gamma, GM-CSF, or IL-4., [RefSeq, PubMed]; Expression patterns of PD-L1 and PD-L2 with the cells of lymphohematopoietic tissues exclusively expressing the former, [RefSeq, PubMed]; Most normal tissues and cardiac isografts had minimal expression of PD-1, PD-L1, or PD-L2, but intragraft induction of all three molecules occurred during development of cardiac allograft rejection, [RefSeq, PubMed]; Pan-cancer analysis identifies PD-L2 as a tumor promotor in the tumor microenvironment. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11224527, PubMed:11283156, PubMed:12719480, PubMed:18641123). Acts as a ligand for the inhibitory receptor PDCD1/PD-1, inhibiting T-cell proliferation by blocking cell cycle progression and cytokine production (PubMed:11224527, PubMed:11283156, PubMed:12719480, PubMed:18641123)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Upregulation of PD-1 and its ligands and expansion of T peripheral helper cells in the nephritic kidneys of lupus-prone BXSB-Yaa mice., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0032693 negative regulation of interleukin-10 production;GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0031295 T cell costimulation;GO:0032689 negative regulation of type II interferon production", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WUL5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWY8-1", "uniprot_id": "RNH2A_MOUSE", "mass": 33513.0, "length": 301, "protein_name": "Ribonuclease H2 subunit A", "gene_name": "Rnaseh2a", "organism": "Mouse", "refseq_name": "ribonuclease H2 subunit A isoform 1", "refseq_ac": "NP_081463", "gene_names_uniprotkb": "Rnaseh2a; Rnasehi", "gene_names_refseq": "2400006P09Rik; RNASEHI; RNHIA; RNHL; Rnaseh2a", "protein_names_uniprotkb": "Ribonuclease H2 subunit A; 3.1.26.4; RNase H2 subunit A; RNase HI large subunit; Ribonuclease HI large subunit; Ribonuclease HI subunit A", "protein_names_refseq": "RNase H2 subunit A; RNase HI large subunit; ribonuclease H2 subunit A isoform 1; ribonuclease H2 subunit A; ribonuclease HI large subunit; ribonuclease HI subunit A", "tax_id": 10090, "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629)", "pathway": " (mmu:69724)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "17242355;19923215;21183079;21454563;21750661;23744109;26880576;30084848;30380406;30779550;34428180;36577784", "class_list": "", "function": "An RNase H2 mutant lacking ribonucleotide excision repair activity but supporting R-loop removal revealed that ribonucleotides in DNA initiate p53-dependent DNA damage response and early embryonic arrest in mouse., [RefSeq, PubMed]; Analysis of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome, [RefSeq, PubMed]; Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Data show that the interwoven architecture of RNase H2B and RNase H2C that interface with RNase H2A in a complex ideally suited for nucleic acid binding and hydrolysis coupled to protein-protein interaction motifs., [RefSeq, PubMed]; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids., [UniProtKB, UniProtKB, UniProtKB]; RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells. Erratum:[Commun Biol. 2025 Dec 30;8(1):1856. doi: 10.1038/s42003-025-09392-y. PMID: 41469483] Publication Status: Online-Only, [RefSeq, PubMed]; Recent evidence gathered from ribonuclease H2 knock-out mice provides insight into the molecular mechanisms underlying Aicardi-Goutieres syndrome development and a potential role of DNA damage as a trigger of autoimmunity is discussed. [review] Review article, [RefSeq, PubMed]; The G37S mutation of RNaseH2 led to increased expression of interferon-stimulated genes dependent on the cGAS-STING signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHY8", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0004523 RNA-DNA hybrid ribonuclease activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0032299 ribonuclease H2 complex", "go_biological_process": "GO:0006298 mismatch repair;GO:0043137 DNA replication, removal of RNA primer;GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9CWY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NXY9-1", "uniprot_id": "RPC7_MOUSE", "mass": 25947.0, "length": 223, "protein_name": "DNA-directed RNA polymerase III subunit RPC7", "gene_name": "Polr3g", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase III subunit RPC7", "refseq_ac": "NP_001074645", "gene_names_uniprotkb": "Polr3g", "gene_names_refseq": "2310047G20Rik; Polr3g; RPC32; RPC7", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC7; DNA-directed RNA polymerase III subunit G; RNA polymerase III subunit C7", "protein_names_refseq": "DNA-directed RNA polymerase III subunit G; DNA-directed RNA polymerase III subunit RPC7; RNA polymerase III subunit C7", "tax_id": 10090, "disease": "", "pathway": " (mmu:67486); (R-MMU-76061); (R-MMU-76066); (R-MMU-76071)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "21898682;24107381;25428506;30084848;32576691", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (By similarity). Acts as a long tether that bridges POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer and the mobile stalk of Pol III, coordinating the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state. Pol III exists as two alternative complexes defined by the mutually exclusive incorporation of subunit POLR3G/RPC7alpha or POLR3GL/RPC7beta. POLR3G/RPC7alpha modulates Pol III transcriptome by specifically enhancing the transcription of snaR-A non-coding RNAs. At resting state, occupies the active site of apo Pol III and keeps Pol III in an autoinhibitory mode, preventing non-specific transcription (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity)., [UniProtKB, UniProtKB]; Functions of paralogous RNA polymerase III subunits POLR3G and POLR3GL in mouse development., [RefSeq, PubMed]; POLR3G is absent in unfertilized oocytes and present predominately in the cytoplasm in fertilized zygotes and two cell embryos., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0W5;Q9CV05", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0008283 cell population proliferation;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6NXY9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6UJY2-1", "uniprot_id": "SL9C1_MOUSE", "mass": 135545.0, "length": 1175, "protein_name": "Solute carrier family 9 member C1", "gene_name": "Slc9c1", "organism": "Mouse", "refseq_name": "solute carrier family 9 member C1", "refseq_ac": "NP_932774", "gene_names_uniprotkb": "Slc9c1; Gm610; Slc9a10", "gene_names_refseq": "Gm610; NHE-10; Slc9a10; Slc9c1; sNHE; spermNHE", "protein_names_uniprotkb": "Solute carrier family 9 member C1; NHE-10; Na(+)/H(+) exchanger 10; Sodium/hydrogen exchanger 10; Solute carrier family 10 member 10; Sperm-specific Na(+)/H(+) exchanger; sNHE", "protein_names_refseq": "Na(+)/H(+) exchanger 10; sodium/hydrogen exchanger 10; solute carrier family 10 member 10; solute carrier family 9 member C1; solute carrier family 9, member 10; sperm-specific Na(+)/H(+) exchanger; sperm-specific sodium proton exchanger", "tax_id": 10090, "disease": "", "pathway": " (mmu:208169)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12783626;14634667;17517652;21750661;37669933", "class_list": "", "function": "Sperm-specific Na+/H+ exchanger is required for the expression of full-length soluble adenylyl cyclase, [RefSeq, PubMed]; Sperm-specific solute carrier involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E0CX34;Q7M6Y7", "ec_number_list": "", "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015386 potassium:proton antiporter activity;GO:0005216 monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031514 motile cilium;GO:0060170 ciliary membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0030317 flagellated sperm motility;GO:0051453 regulation of intracellular pH;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6UJY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11031-1", "uniprot_id": "TCP4_MOUSE", "mass": 14427.0, "length": 127, "protein_name": "Activated RNA polymerase II transcriptional coactivator p15", "gene_name": "Sub1", "organism": "Mouse", "refseq_name": "activated RNA polymerase II transcriptional coactivator p15", "refseq_ac": "NP_035424", "gene_names_uniprotkb": "Sub1; Pc4; Rpo2tc1", "gene_names_refseq": "P15; P9; Pc4; Rpo2tc1; Sub1", "protein_names_uniprotkb": "Activated RNA polymerase II transcriptional coactivator p15; PC4; Positive cofactor 4; SUB1 homolog; Single-stranded DNA-binding protein p9; p14", "protein_names_refseq": "RNA polymerase II transcriptional coactivator; activated RNA polymerase II transcriptional coactivator p15; p14; positive cofactor 4; single-stranded DNA-binding protein p9", "tax_id": 10090, "disease": "", "pathway": " (mmu:20024)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16003322;21183079;23806337;26740582;27471272;3372536;34428180;38820928", "class_list": "", "function": "General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA)., [UniProtKB]; PC4 promotes bladder cancer progression and stemness by directly interacting with Sp1 to transcriptionally activate the Wnt5a/beta-catenin pathway., [RefSeq, PubMed]; Redox-mediated upregulation of hepatocyte iNOS transcription requires an HNF-4alpha-PC4 transcriptional complex, [RefSeq, PubMed]; Results suggest that positive cofactor 4 (Pc4) has an important role in inducing spontaneous somatic cell reprogramming via up-regulation of key pluripotency genes., [RefSeq, PubMed]; These observations indicate that non-histone chromatin-associated proteins like PC4 play a significant role in neuronal plasticity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJR5;Q543N2", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding;GO:0003690 double-stranded DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0051053 negative regulation of DNA metabolic process;GO:0001111 RNA polymerase II promoter clearance", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P11031-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80Z71-1", "uniprot_id": "TENN_MOUSE", "mass": 173090.0, "length": 1560, "protein_name": "Tenascin-N", "gene_name": "Tnn", "organism": "Mouse", "refseq_name": "tenascin-N precursor", "refseq_ac": "NP_808507", "gene_names_uniprotkb": "Tnn; Tnw", "gene_names_refseq": "TN-W; Tnn; Tnw; tenascin-W", "protein_names_uniprotkb": "Tenascin-N; TN-N; TN-W; Tenascin-W", "protein_names_refseq": "TN-N; tenascin-N precursor; tenasin W", "tax_id": 10090, "disease": "", "pathway": " (mmu:329278); (R-MMU-3000178)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12812753;14709716;15592496;17395156;21750661;22211116;30084848;31219806;34428180;36206596", "class_list": "", "function": "Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:14709716). Involved in neurite outgrowth and cell migration in hippocampal explants (PubMed:12812753). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (PubMed:17395156). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:15592496)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1. Involved in neurite outgrowth and cell migration in hippocampal explants. During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells. Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells., [UniProtKB, UniProtKB]; TNN is first linked to auditory neuropathy., [RefSeq, PubMed]; Tenascin-W is expressed during palate formation, osteogenesis and smooth muscle development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EHR3;Q70HX0", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0043025 neuronal cell body;GO:0043005 neuron projection", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:1903010 regulation of bone development;GO:0007409 axonogenesis;GO:0010976 positive regulation of neuron projection development;GO:0030155 regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q80Z71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3URQ0-1", "uniprot_id": "TEX10_MOUSE", "mass": 105209.0, "length": 928, "protein_name": "Testis-expressed protein 10", "gene_name": "Tex10", "organism": "Mouse", "refseq_name": "testis-expressed protein 10 isoform 1", "refseq_ac": "NP_758508", "gene_names_uniprotkb": "Tex10", "gene_names_refseq": "2610206N19Rik; 2810462N03Rik; Tex10", "protein_names_uniprotkb": "Testis-expressed protein 10", "protein_names_refseq": "clone 18330; testis-expressed protein 10 isoform 1; testis-expressed protein 10; testis-expressed sequence 10 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:269536); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;22872859;25428506;25936917;30084848;31219806;34428180;37792308", "class_list": "", "function": "Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity)., [UniProtKB, UniProtKB, PubMed]; Recruitment of the protein complex 5FMC to Zbp-89, a zinc-finger transcription factor, affects its sumoylation status and transactivation potential.[5FMC], [RefSeq, PubMed]; Tex10 interacts with STAT3 to regulate hepatocellular carcinoma growth and metastasis., [RefSeq, PubMed]; Tex10 is a core component of the pluripotency network., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0071339 MLL1 complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3URQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F8VPN2-1", "uniprot_id": "TEX15_MOUSE", "mass": 311280.0, "length": 2785, "protein_name": "Testis-expressed protein 15", "gene_name": "Tex15", "organism": "Mouse", "refseq_name": "testis-expressed protein 15", "refseq_ac": "NP_113551", "gene_names_uniprotkb": "Tex15", "gene_names_refseq": "2210014E14Rik; Tex15", "protein_names_uniprotkb": "Testis-expressed protein 15", "protein_names_refseq": "testis-expressed protein 15; testis-expressed sequence 15 protein", "tax_id": 10090, "disease": "spermatogenic failure 25 (Disease Ontology:DOID:0111920)", "pathway": " (mmu:104271)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11279525;18283110;21750661;31219806;32381626;32719317", "class_list": "", "function": "Based on these data, we propose that TEX15 regulates the loading of DNA repair proteins onto sites of DSBs and, thus, its absence causes a failure in meiotic recombination. GeneRIF: Tex15 is essential for male meiosis and for chromosomal synapsis. DNA double-strand breaks (DSBs) are formed but not repaired in Tex15-deficient males., [RefSeq, PubMed]; Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair (PubMed:18283110). Essential executor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (PubMed:32381626, PubMed:32719317). PIWIL4-piRNA binds to nascent transposon transcripts and interacts with TEX15, which may in turn recruit the epigenetic silencing machinery to the transposon loci (PubMed:32381626). Not required for piRNA biosynthesis (PubMed:32381626, PubMed:32719317)., [UniProtKB, PubMed, PubMed, PubMed]; TEX15 associates with MILI and silences transposable elements in male germ cells. GeneRIF: Loss of TEX15 leads to DNA hypomethylation and de-silencing of transposable elements, at a level comparable to loss of MILI or DNMT3C but not MIWI2. TEX15 is associated with MILI in testis. piRNA biogenesis is intact in TEX15-deficient male germ cells., [RefSeq, PubMed]; TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPQ6;Q3V162;Q99MV3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0007283 spermatogenesis;GO:0009566 fertilization;GO:0030154 cell differentiation;GO:0048873 homeostasis of number of cells within a tissue", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "F8VPN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QZT1-1", "uniprot_id": "THIL_MOUSE", "mass": 44816.0, "length": 424, "protein_name": "Acetyl-CoA acetyltransferase, mitochondrial", "gene_name": "Acat1", "organism": "Mouse", "refseq_name": "acetyl-CoA acetyltransferase, mitochondrial precursor", "refseq_ac": "NP_659033", "gene_names_uniprotkb": "Acat1", "gene_names_refseq": "6330585C21Rik; Acat1; Acat", "protein_names_uniprotkb": "Acetyl-CoA acetyltransferase, mitochondrial; 2.3.1.9; Acetoacetyl-CoA thiolase", "protein_names_refseq": "acetoacetyl-CoA thiolase; acetyl-CoA acetyltransferase, mitochondrial precursor; acetyl-CoA acetyltransferase, mitochondrial", "tax_id": 10090, "disease": "nephrotic syndrome (Disease Ontology:DOID:1184); beta-ketothiolase deficiency (Disease Ontology:DOID:14723); arteriosclerosis (Disease Ontology:DOID:2349); carbohydrate metabolic disorder (Disease Ontology:DOID:2978); end stage renal disease (Disease Ontology:DOID:783); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:110446); (R-MMU-70895); (R-MMU-77108); (R-MMU-77111); (R-MMU-9837999); (R-MMU-9854311)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "21183079;23576753;23806337;26740625;31361958;33300544;34428180;36288343;37453647;37507081;37879607;39927985;40684658", "class_list": "", "function": "SCD1 inhibition enhances the effector functions of CD8[+] T cells via ACAT1-dependent reduction of esterified cholesterol., [RefSeq, PubMed]; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TE92", "ec_number_list": "3.5.3.1;1.8.1.4;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;5.3.3.21;3.1.2.-;3.1.2.2;3.4.21.92;1.1.1.37;4.98.1.1;1.4.1.3;1.2.4.1;3.6.4.10;5.3.3.8;1.2.1.3;2.3.1.168;1.1.1.42;2.3.3.10;7.1.2.2;5.6.1.7;4.2.1.2;1.2.4.2;1.1.1.30;2.7.11.2;6.1.1.5;3.1.2.1;2.3.1.16;2.3.1.9;2.7.1.23;3.4.21.53;5.6.2.3;2.3.1.37;2.3.1.155;7.1.1.2;1.1.1.38;4.2.1.3;6.4.1.3;1.2.1.36;1.7.1.-;1.2.1.28;2.3.3.1;2.8.3.5;2.3.1.41;1.1.1.41;1.3.8.5;1.3.8.1;6.2.1.-;6.2.1.4", "go_molecular_function": "GO:0120225 coenzyme A binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0030955 potassium ion binding;GO:0034736 cholesterol O-acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0001889 liver development;GO:0006635 fatty acid beta-oxidation;GO:0042594 response to starvation;GO:0060612 adipose tissue development;GO:0006085 acetyl-CoA biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8QZT1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CY27-1", "uniprot_id": "TECR_MOUSE", "mass": 36090.0, "length": 308, "protein_name": "Very-long-chain enoyl-CoA reductase", "gene_name": "Tecr", "organism": "Mouse", "refseq_name": "very-long-chain enoyl-CoA reductase isoform 2", "refseq_ac": "NP_081455", "gene_names_uniprotkb": "Tecr; Gpsn2", "gene_names_refseq": "2410016D23Rik; A230102P12Rik; D17Ertd178e; Gpsn2; SC2; Tecr", "protein_names_uniprotkb": "Very-long-chain enoyl-CoA reductase; 1.3.1.93; Synaptic glycoprotein SC2; TER; Trans-2,3-enoyl-CoA reductase", "protein_names_refseq": "TER; glycoprotein, synaptic 2; synaptic glycoprotein SC2; very-long-chain enoyl-CoA reductase isoform 2; very-long-chain enoyl-CoA reductase", "tax_id": 10090, "disease": "non-syndromic intellectual disability (Disease Ontology:DOID:0050889); autosomal recessive intellectual developmental disorder 14 (Disease Ontology:DOID:0081188)", "pathway": " (mmu:106529); (R-MMU-75876)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "12482854;16341590;17208939;21750661;22645316;23806337;25428506;28528544;30084848;33300544;34428180;35820727;36210013;37453647", "class_list": "glycogene", "function": "Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (By similarity). Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (By similarity). This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (By similarity). This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation (By similarity). Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity). Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results describe the sequence and distribution of mouse synaptic glycoprotein homolog 2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 28, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.3.1.-;1.3.1.93", "go_molecular_function": "GO:0102758 very-long-chain enoyl-CoA reductase activity;GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0006694 steroid biosynthetic process;GO:0030497 fatty acid elongation;GO:0042761 very long-chain fatty acid biosynthetic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9CY27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99MV2-1", "uniprot_id": "TX19A_MOUSE", "mass": 40401.0, "length": 351, "protein_name": "Testis-expressed protein 19.1", "gene_name": "Tex19.1", "organism": "Mouse", "refseq_name": "testis-expressed protein 19.1", "refseq_ac": "NP_082878", "gene_names_uniprotkb": "Tex19.1; Tex19a; Tex19", "gene_names_refseq": "2410081M02Rik; Tex19.1; Tex19a; Tex19; mTex19.1", "protein_names_uniprotkb": "Testis-expressed protein 19.1; Testis-expressed protein 19A; mTex19.1", "protein_names_refseq": "testis expressed gene 19; testis-expressed protein 19.1; testis-expressed protein 19A; testis-expressed sequence 19A", "tax_id": 10090, "disease": "", "pathway": " (mmu:73679)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11279525;18096721;18802469;19247806;21103378;21750661;22447323;23364048;23674551;28254886;28708824;28806172;32232464", "class_list": "", "function": "Here the authors show that TEX19.1, which is induced by developmentally programmed DNA hypomethylation, can directly interact with the LINE-1 (L1) retrotransposon-encoded protein L1-ORF1p, stimulate its polyubiquitylation and degradation, and restrict L1 mobilization. Publication Status: Online-Only, [RefSeq, PubMed]; Mouse DAZL protein can bind to 3'UTR of mTex19.1 mRNAs and may repress mTex19.1 expression at the translational level.Confirmed by both electrophoretic mobility shift assay and translation assay in Zebrafish embryo detecting the luciferase activity., [RefSeq, PubMed]; Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and preventing their mobilization (PubMed:18802469, PubMed:21103378, PubMed:23364048, PubMed:23674551, PubMed:28254886). With its paralog, Tex19.2, collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:28254886). Also during spermatogenesis, promotes, with UBR2, SPO11-dependent meiotic recombination (PubMed:28708824). Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization (PubMed:28806172)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Results suggest that the binding of Ubr2 to Tex19.1 metabolically stabilizes Tex19.1 during spermatogenesis, revealing a new function for Ubr2 outside the conventional N-end rule pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Tex19 is a mammalian-specific protein duplicated in mouse and rat, renamed Tex19.1 and Tex19.2, whereas only one form is found in human., [RefSeq, PubMed]; Tex19.1 inhibits the N-end rule pathway and maintains acetylated SMC3 cohesin and sister chromatid cohesion in oocytes., [RefSeq, PubMed]; Tex19.1 repressed transposable genetic elements and maintained genomic stability through successive generations. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPF0", "ec_number_list": "", "go_molecular_function": "GO:0034584 piRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0010608 post-transcriptional regulation of gene expression;GO:0001890 placenta development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q99MV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZ98-1", "uniprot_id": "DYN3_MOUSE", "mass": 97190.0, "length": 863, "protein_name": "Dynamin-3", "gene_name": "Dnm3", "organism": "Mouse", "refseq_name": "dynamin-3 isoform 1", "refseq_ac": "NP_001033708", "gene_names_uniprotkb": "Dnm3; Kiaa0820", "gene_names_refseq": "9630020E24Rik; B230343F03Rik; C530045C17; Dnm3; Dyna III; mKIAA0820", "protein_names_uniprotkb": "Dynamin-3; 3.6.5.5", "protein_names_refseq": "dynamin III; dynamin-3 isoform 1; t-dynamin; testicular dynamin", "tax_id": 10090, "disease": "collagen disease (Disease Ontology:DOID:854)", "pathway": " (mmu:103967); (R-MMU-166016); (R-MMU-2132295); (R-MMU-437239); (R-MMU-8856828)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;17114649;19007685;21750661;30059200;33300544;34203471;34428180;35820727;38641407", "class_list": "", "function": "Dynamin 3 participates in the growth and development of megakaryocytes., [RefSeq, PubMed]; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP (By similarity). Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B2RUH0;Q3UGY9;Q80TR2;Q8BWW6", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;2.3.2.27;5.6.1.6;3.6.5.5;3.6.4.-;3.6.4.10;2.7.10.1;3.6.1.-;3.6.1.15;2.7.11.1;3.1.3.86;3.1.3.56;3.1.3.36;3.1.3.-;3.6.-.-;3.1.4.11", "go_molecular_function": "GO:0031798 type 1 metabotropic glutamate receptor binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098844 postsynaptic endocytic zone membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005874 microtubule", "go_biological_process": "GO:0006897 endocytosis;GO:0046847 filopodium assembly;GO:0007416 synapse assembly;GO:0051491 positive regulation of filopodium assembly;GO:0061001 regulation of dendritic spine morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8BZ98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UR70-1", "uniprot_id": "TGFA1_MOUSE", "mass": 97303.0, "length": 860, "protein_name": "Transforming growth factor-beta receptor-associated protein 1", "gene_name": "Tgfbrap1", "organism": "Mouse", "refseq_name": "transforming growth factor-beta receptor-associated protein 1", "refseq_ac": "NP_001013043", "gene_names_uniprotkb": "Tgfbrap1", "gene_names_refseq": "3110018K12Rik; Tgfbrap1; Trap1", "protein_names_uniprotkb": "Transforming growth factor-beta receptor-associated protein 1; TGF-beta receptor-associated protein 1; TRAP-1; TRAP1", "protein_names_refseq": "TGF beta receptor associated protein 1; TRAP-1; tansforming growth factor, beta receptor associated protein 1; transforming growth factor-beta receptor-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:73122)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12529173;19520754;20961651;21750661;25266290;31219806;34428180", "class_list": "", "function": "CHGA triggered secretion of endothelin-1 from glomerular endothelial cells and TGF-beta1 from mesangial cells cocultured with glomerular endothelial cells., [RefSeq, PubMed]; Our data indicate that TRAP1 and VPS39 are nonredundant and essentially required for early embryonic development, [RefSeq, PubMed]; Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2 (By similarity)., [UniProtKB]; Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo (By similarity)., [UniProtKB, UniProtKB]; The Fn14 cytoplasmic tail binds this protein and mediates nuclear factor-kappaB activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKN4", "ec_number_list": "", "go_molecular_function": "GO:0005160 transforming growth factor beta receptor binding;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0016020 membrane;GO:0033263 CORVET complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007165 signal transduction;GO:0006355 regulation of DNA-templated transcription;GO:0008333 endosome to lysosome transport;GO:0034058 endosomal vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3UR70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06335-1", "uniprot_id": "APLP2_MOUSE", "mass": 80467.0, "length": 707, "protein_name": "Amyloid beta precursor like protein 2", "gene_name": "Aplp2", "organism": "Mouse", "refseq_name": "amyloid beta precursor like protein 2 isoform b precursor", "refseq_ac": "NP_001095926", "gene_names_uniprotkb": "Aplp2; APPL2", "gene_names_refseq": "APLP-2; Aplp2; CDEBP", "protein_names_uniprotkb": "Amyloid beta precursor like protein 2; APLP-2; Amyloid beta (A4) precursor-like protein 2; Amyloid protein homolog; Amyloid-like protein 2; CDEBP; CDEI box-binding protein; Sperm membrane protein YWK-II", "protein_names_refseq": "CDE1-binding protein CDEBP; CDEI box-binding protein; amyloid beta (A4) precursor-like protein 2; amyloid beta precursor like protein 2 isoform b precursor; amyloid protein homolog; amyloid-like protein 2; sperm membrane protein YWK-II", "tax_id": 10090, "disease": "Alzheimer's disease 1 (Disease Ontology:DOID:0080348); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:11804); (R-MMU-114608); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11247302;1482349;15677459;16075062;16314516;21750661;34428180;35820727;36442651;36852467;37828378;37844466;7592716;8218408", "class_list": "", "function": "May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Mycobacterium tuberculosis suppresses APLP2 expression to enhance its survival in macrophage., [RefSeq, PubMed]; Reduced expression of APLP2 in spinal GABAergic inhibitory neurons contributed to nerve injury-induced microglial activation and pain sensitization., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80US7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0046914 transition metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0097444 spine apparatus;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0001967 suckling behavior;GO:0006878 intracellular copper ion homeostasis;GO:0007409 axonogenesis;GO:0007617 mating behavior;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q06335-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1A0-1", "uniprot_id": "PXL2C_MOUSE", "mass": 24904.0, "length": 226, "protein_name": "Peroxiredoxin-like 2C", "gene_name": "Prxl2c", "organism": "Mouse", "refseq_name": "peroxiredoxin-like 2C", "refseq_ac": "NP_079646", "gene_names_uniprotkb": "Prxl2c; Aaed1", "gene_names_refseq": "1110018J18Rik; Aaed1; Prxl2c", "protein_names_uniprotkb": "Peroxiredoxin-like 2C; AhpC/TSA antioxidant enzyme domain-containing protein 1; Thioredoxin-like protein AAED1", "protein_names_refseq": "AhpC/TSA antioxidant enzyme domain containing 1; UPF0308 protein C9orf21 homolog; ahpC/TSA antioxidant enzyme domain-containing protein 1; peroxiredoxin-like 2C; thioredoxin-like protein AAED1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66129)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "May positively regulate ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFP2;Q9CVT8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0045821 positive regulation of glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D1A0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZI9-1", "uniprot_id": "AEN_MOUSE", "mass": 37309.0, "length": 336, "protein_name": "Apoptosis-enhancing nuclease", "gene_name": "Aen", "organism": "Mouse", "refseq_name": "apoptosis-enhancing nuclease isoform 2", "refseq_ac": "NP_001156411", "gene_names_uniprotkb": "Aen; Isg20l1", "gene_names_refseq": "2700083B06Rik; Aen; Isg20l1", "protein_names_uniprotkb": "Apoptosis-enhancing nuclease; 3.1.-.-; Interferon-stimulated 20 kDa exonuclease-like 1", "protein_names_refseq": "apoptosis-enhancing nuclease isoform 2; interferon stimulated exonuclease gene 20-like 1; interferon-stimulated 20 kDa exonuclease-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68048)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKV9;Q8BTJ8;Q8C095", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0004527 exonuclease activity;GO:0004529 DNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006396 RNA processing;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0010212 response to ionizing radiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CZI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921H8-1", "uniprot_id": "THIKA_MOUSE", "mass": 43953.0, "length": 424, "protein_name": "3-ketoacyl-CoA thiolase A, peroxisomal", "gene_name": "Acaa1a", "organism": "Mouse", "refseq_name": "3-ketoacyl-CoA thiolase A, peroxisomal isoform 1 precursor", "refseq_ac": "NP_570934", "gene_names_uniprotkb": "Acaa1a; Acaa1", "gene_names_refseq": "Acaa1a; Acaa1; Acaa; D9Ertd25e; PTL", "protein_names_uniprotkb": "3-ketoacyl-CoA thiolase A, peroxisomal; 2.3.1.155; 2.3.1.16; 2.3.1.9; Acetyl-CoA C-myristoyltransferase; Acetyl-CoA acyltransferase A; Beta-ketothiolase A; Peroxisomal 3-oxoacyl-CoA thiolase A", "protein_names_refseq": "3-ketoacyl-CoA thiolase A, peroxisomal isoform 1 precursor; 3-ketoacyl-CoA thiolase A, peroxisomal; acetyl-CoA C-myristoyltransferase; acetyl-CoA acyltransferase A; beta-ketothiolase A; peroxisomal 3-ketoacyl-CoA thiolase; peroxisomal 3-oxoacyl-CoA thiolase A; peroxisomal 3-oxoacyl-Coenzyme A thiolase", "tax_id": 10090, "disease": "", "pathway": " (mmu:113868)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;15043762;21750661;23576753;34465723;35820727;36288343;37453647", "class_list": "", "function": "A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-beta pathology and cognitive decline. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular cloning, gene structure and tissue distribution of 3-ketoacyl-CoA thiolase A. Publication Status: Online-Only, [RefSeq, PubMed]; Responsible for the thiolytic cleavage of straight chain 3-keto fatty acyl-CoAs (3-oxoacyl-CoAs) (Probable). Plays an important role in fatty acid peroxisomal beta-oxidation (Probable). Catalyzes the cleavage of short, medium, long, and very long straight chain 3-oxoacyl-CoAs (By similarity). May play a role in peroxisomal beta-oxidation step in polyunsaturated fatty acids (PUFAs) biosynthesis. Possibly regulates systemic levels of docosahexaenoic acid (DHA, C22:6n-3) through a process involving endoplasmic reticulum desaturation and elongation of alpha-linolenic acid (ALA, C18:3n-3) to form tetracosahexaenoic acid (THA, C24:6n-3), which is then beta-oxidized to DHA in peroxisomes., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.176;2.3.1.16;2.3.1.155;3.1.2.-;3.1.2.2;3.1.2.1;2.3.1.9;3.4.21.-", "go_molecular_function": "GO:0003988 acetyl-CoA C-acyltransferase activity;GO:0003985 acetyl-CoA C-acetyltransferase activity;GO:0008775 acetate CoA-transferase activity;GO:0050633 acetyl-CoA C-myristoyltransferase activity;GO:0120524 long-chain fatty acyl-CoA oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0010124 phenylacetate catabolic process;GO:0000038 very long-chain fatty acid metabolic process;GO:0006631 fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0007584 response to nutrient", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q921H8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RUR8-1", "uniprot_id": "OTU7B_MOUSE", "mass": 91983.0, "length": 840, "protein_name": "OTU domain-containing protein 7B", "gene_name": "Otud7b", "organism": "Mouse", "refseq_name": "OTU domain-containing protein 7B", "refseq_ac": "NP_001020784", "gene_names_uniprotkb": "Otud7b", "gene_names_refseq": "2900060B22Rik; 4930463P07Rik; CEZANNE; Otud7b; Trabid2; Za20d1", "protein_names_uniprotkb": "OTU domain-containing protein 7B; 3.4.19.12; Cellular zinc finger anti-NF-kappa-B protein; Zinc finger A20 domain-containing protein 1; Zinc finger protein Cezanne", "protein_names_refseq": "OTU domain-containing protein 7B; TRAF binding domain containing 2; cellular zinc finger anti-NF-kappa-B protein; zinc finger A20 domain-containing protein 1; zinc finger protein Cezanne; zinc finger, A20 domain containing 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:229603); (R-MMU-5357786); (R-MMU-5357905); (R-MMU-5357956); (R-MMU-5689896)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "17242355;21097510;21183079;21750661;22645316;23334419;26903241;29562282;34203471;37516734;38084712", "class_list": "", "function": "DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB., [RefSeq, PubMed]; Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:23334419). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (PubMed:23334419). Negatively regulates mucosal immunity against infections (PubMed:23334419). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (PubMed:26903241). Mediates deubiquitination of EGFR (By similarity). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (By similarity). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (By similarity). Hydrolyzes both linear and branched forms of polyubiquitin (By similarity). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inhibiting formation of the mTORC1 complex (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Ovarian Tumor Domain-Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Kruppel-Like Factor 4., [RefSeq, PubMed]; The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFS0", "ec_number_list": "3.4.19.12;2.3.2.27;2.7.11.10;2.7.11.1;2.3.2.-;2.7.11.25;2.3.2.31", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0008234 cysteine-type peptidase activity;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0016579 protein deubiquitination;GO:0070536 protein K63-linked deubiquitination;GO:1900181 negative regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "B2RUR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNP2-1", "uniprot_id": "2AAB_MOUSE", "mass": 65934.0, "length": 601, "protein_name": "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "gene_name": "Ppp2r1b", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform b", "refseq_ac": "NP_082890", "gene_names_uniprotkb": "Ppp2r1b", "gene_names_refseq": "2410091N08Rik; Ppp2r1b", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; PP2A subunit A isoform PR65-beta; PP2A subunit A isoform R1-beta", "protein_names_refseq": "serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform b", "tax_id": 10090, "disease": "lung cancer (Disease Ontology:DOID:1324)", "pathway": " (mmu:73699); (R-MMU-113501); (R-MMU-141430); (R-MMU-141444); (R-MMU-180024); (R-MMU-195253); (R-MMU-196299); (R-MMU-198753); (R-MMU-202670); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-389356); (R-MMU-389513); (R-MMU-432142); (R-MMU-4641262); (R-MMU-5663220); (R-MMU-5673000); (R-MMU-5675221); (R-MMU-6804757); (R-MMU-6811558); (R-MMU-68877); (R-MMU-69231); (R-MMU-69273); (R-MMU-9648025); (R-MMU-9833482); (R-MMU-9860927)", "pathway_count": 26, "publication_count": 11, "publication_id_list": "18250455;18299400;18432318;20173027;21750661;21952136;22827437;25605945;33913576;34428180;37828378", "class_list": "", "function": "Multiple transcription factors regulate the PP2A-Abeta gene., [RefSeq, PubMed]; PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed. Publication Status: Online-Only, [RefSeq, PubMed]; PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis., [RefSeq, PubMed]; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QNJ1", "ec_number_list": "", "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045121 membrane raft", "go_biological_process": "GO:0051754 meiotic sister chromatid cohesion, centromeric;GO:0060561 apoptotic process involved in morphogenesis;GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7TNP2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F2F2-1", "uniprot_id": "ABH15_MOUSE", "mass": 51152.0, "length": 459, "protein_name": "Protein ABHD15", "gene_name": "Abhd15", "organism": "Mouse", "refseq_name": "protein ABHD15 precursor", "refseq_ac": "NP_080461", "gene_names_uniprotkb": "Abhd15", "gene_names_refseq": "1300007F04Rik; Abhd15", "protein_names_uniprotkb": "Protein ABHD15; Abhydrolase domain-containing protein 15; Alpha/beta hydrolase domain-containing protein 15", "protein_names_refseq": "abhydrolase domain-containing protein 15; alpha/beta hydrolase domain-containing protein 15; protein ABHD15 precursor; protein ABHD15", "tax_id": 10090, "disease": "", "pathway": " (mmu:67477)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;24236098;29768196;30084848;31105056;33775605", "class_list": "", "function": "ABHD15 associates with and stabilizes phosphodiesterase 3B (PDE3B)., [RefSeq, PubMed]; ABHD15 is an essential component in the development of adipocytes as well as in apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; ABHD15 protein levels were reduced in adipocytes from mice fed a Western diet, further implicating this protein in metabolic homeostasis. Erratum:[Mol Metab. 2021 Jun;48:101219. doi: 10.1016/j.molmet.2021.101219. PMID: 33775605], [RefSeq, PubMed]; May regulate adipocyte lipolysis and liver lipid accumulation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V371;Q8C9I5;Q8CF57;Q9CU23", "ec_number_list": "", "go_molecular_function": "GO:0047372 monoacylglycerol lipase activity;GO:0034338 short-chain carboxylesterase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0060612 adipose tissue development;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5F2F2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14869-1", "uniprot_id": "RLA0_MOUSE", "mass": 34216.0, "length": 317, "protein_name": "Large ribosomal subunit protein uL10", "gene_name": "Rplp0", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL10", "refseq_ac": "NP_031501", "gene_names_uniprotkb": "Rplp0; Arbp", "gene_names_refseq": "36B4; Arbp; L10E; Rplp0", "protein_names_uniprotkb": "Large ribosomal subunit protein uL10; 60S acidic ribosomal protein P0; 60S ribosomal protein L10E", "protein_names_refseq": "60S acidic ribosomal protein P0; 60S ribosomal protein L10E; acidic ribosomal phosphoprotein P0; large ribosomal subunit protein uL10; ribosomal protein, large, P0", "tax_id": 10090, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (mmu:11837); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 29, "publication_id_list": "15345747;17242355;17322886;17947660;18250455;18630941;19131326;19144319;21183079;21540332;21750661;22645316;25428506;25605945;26495903;26740625;2771657;28011936;30084848;31219806;31599954;33725478;34428180;35820727;35984892;37453647;37507081;37828378;39627609", "class_list": "", "function": "Ribosomal protein P0 is the functional equivalent of E.coli protein L10., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99L54", "ec_number_list": "", "go_molecular_function": "GO:0042277 peptide binding;GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0042254 ribosome biogenesis;GO:0006941 striated muscle contraction;GO:0071353 cellular response to interleukin-4", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P14869-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61312-1", "uniprot_id": "AP2C_MOUSE", "mass": 49137.0, "length": 449, "protein_name": "Transcription factor AP-2 gamma", "gene_name": "Tfap2c", "organism": "Mouse", "refseq_name": "transcription factor AP-2 gamma isoform 2", "refseq_ac": "NP_001153168", "gene_names_uniprotkb": "Tfap2c; Tcfap2c", "gene_names_refseq": "AP2gamma; Ap-2.2; Stra2; Tcfap2c; Tfap2c", "protein_names_uniprotkb": "Transcription factor AP-2 gamma; AP-2.2; AP2-gamma; Activating enhancer-binding protein 2 gamma", "protein_names_refseq": "AP2-gamma; activating enhancer-binding protein 2 gamma; stimulated by retinoic acid gene 2; transcription factor AP-2 gamma isoform 2", "tax_id": 10090, "disease": "sleep disorder (Disease Ontology:DOID:535)", "pathway": " (mmu:21420); (R-MMU-3232118); (R-MMU-8866904); (R-MMU-8866907); (R-MMU-8866911); (R-MMU-9834899)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "12504852;21750661;34428180;38243114;8660922", "class_list": "", "function": "Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:38243114, PubMed:8660922). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:38243114, PubMed:8660922). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (PubMed:38243114). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (PubMed:38243114). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (PubMed:38243114). Binds to both closed and open chromatin with other transcription factors (PubMed:38243114)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99L72", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0021877 forebrain neuron fate commitment;GO:0048733 sebaceous gland development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61312-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47740-1", "uniprot_id": "AL3A2_MOUSE", "mass": 53971.0, "length": 484, "protein_name": "Aldehyde dehydrogenase family 3 member A2", "gene_name": "Aldh3a2", "organism": "Mouse", "refseq_name": "aldehyde dehydrogenase family 3 member A2 isoform 2", "refseq_ac": "NP_031463", "gene_names_uniprotkb": "Aldh3a2; Ahd-3; Ahd3; Aldh3; Aldh4", "gene_names_refseq": "Ahd-3r; Ahd-3; Ahd3-r; Ahd3; Aldh3a2; Aldh4-r; Aldh4; FALDH", "protein_names_uniprotkb": "Aldehyde dehydrogenase family 3 member A2; 1.2.1.3; 1.2.1.94; Aldehyde dehydrogenase 3; Fatty aldehyde dehydrogenase", "protein_names_refseq": "alcohol dehydrogenase family 3, subfamily A2; aldehyde dehydrogenase 3; aldehyde dehydrogenase 4, liver microsomal (class 3) regulator; aldehyde dehydrogenase family 3 member A2 isoform 2; aldehyde dehydrogenase family 3 member A2; fatty aldehyde dehydrogenase variant form", "tax_id": 10090, "disease": "Sjogren-Larsson syndrome (Disease Ontology:DOID:14501)", "pathway": " (mmu:11671); (R-MMU-389599); (R-MMU-9603798); (R-MMU-9609523); (R-MMU-9696270); (R-MMU-9696273); (R-MMU-9845614)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "18250455;21750661;25286108;30084848;31599954;32458004;34370553;34428180;37453647;37828378;8634152", "class_list": "", "function": "Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers., [RefSeq, PubMed]; Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:25286108). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:25286108)., [UniProtKB, PubMed]; Impaired Skin Barrier Function Due to Reduced omega-O-Acylceramide Levels in a Mouse Model of Sjogren-Larsson Syndrome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99L64", "ec_number_list": "1.2.1.3;1.2.1.48;3.4.17.22;1.14.14.18;1.2.1.36;1.2.1.19;1.2.1.28;1.2.1.5;1.2.1.94;3.1.2.-;7.6.2.-;2.3.2.27;2.3.2.36;3.6.5.2;2.7.10.1;3.1.3.48;2.3.2.23;1.2.1.7;1.7.1.-;7.4.2.-;1.2.1.31;1.2.1.8;1.2.1.47;1.2.1.46", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004028 3-chloroallyl aldehyde dehydrogenase activity;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0046577 long-chain-alcohol oxidase activity;GO:0050061 long-chain fatty aldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0046458 hexadecanal metabolic process;GO:0006631 fatty acid metabolic process;GO:0008544 epidermis development;GO:0006081 aldehyde metabolic process;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P47740-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGG9-1", "uniprot_id": "ACNT2_MOUSE", "mass": 46595.0, "length": 420, "protein_name": "Acyl-coenzyme A amino acid N-acyltransferase 2", "gene_name": "Acnat2", "organism": "Mouse", "refseq_name": "acyl-coenzyme A amino acid N-acyltransferase 2", "refseq_ac": "NP_663343", "gene_names_uniprotkb": "Acnat2", "gene_names_refseq": "Acnat2; C730036D15Rik", "protein_names_uniprotkb": "Acyl-coenzyme A amino acid N-acyltransferase 2; 2.3.1.-", "protein_names_refseq": "acyl-CoA:amino acid N-acyltransferase 2; acyl-coenzyme A amino acid N-acyltransferase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:209186)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Acyltransferase which efficiently conjugates very long-chain and long-chain fatty acids to taurine. Shows no conjugation activity in the presence of glycine (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2D099;Q91XC7", "ec_number_list": "", "go_molecular_function": "GO:0047617 fatty acyl-CoA hydrolase activity;GO:0016410 N-acyltransferase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BGG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8N9S3-1", "uniprot_id": "AHSA2_MOUSE", "mass": 37648.0, "length": 331, "protein_name": "Activator of 90 kDa heat shock protein ATPase homolog 2", "gene_name": "Ahsa2", "organism": "Mouse", "refseq_name": "activator of 90 kDa heat shock protein ATPase homolog 2 isoform 2", "refseq_ac": "NP_001277583", "gene_names_uniprotkb": "Ahsa2", "gene_names_refseq": "Ahsa2", "protein_names_uniprotkb": "Activator of 90 kDa heat shock protein ATPase homolog 2", "protein_names_refseq": "activator of 90 kDa heat shock protein ATPase homolog 2 isoform 2; activator of 90 kDa heat shock protein ATPase homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:268390)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;28135057", "class_list": "", "function": "Co-chaperone that stimulates HSP90 ATPase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P626;Q6P3F2;Q7TMW7;Q8CBI4", "ec_number_list": "", "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8N9S3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZH7-1", "uniprot_id": "ABHD3_MOUSE", "mass": 46232.0, "length": 411, "protein_name": "Phospholipase ABHD3", "gene_name": "Abhd3", "organism": "Mouse", "refseq_name": "phospholipase ABHD3", "refseq_ac": "NP_598891", "gene_names_uniprotkb": "Abhd3; Labh3", "gene_names_refseq": "Abhd3; LABH3", "protein_names_uniprotkb": "Phospholipase ABHD3; 3.1.1.32; 3.1.1.4; Abhydrolase domain-containing protein 3; Lung alpha/beta hydrolase 3; MmLABH3", "protein_names_refseq": "abhydrolase domain-containing protein 3; lung alpha/beta hydrolase 3; mmLABH3; phospholipase ABHD3", "tax_id": 10090, "disease": "", "pathway": " (mmu:106861); (R-MMU-1483191)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;11922611;21750661;21926997", "class_list": "", "function": "A member of a novel family of membrane bound enzymes whose function has yet to be determined; highest expression level in the liver [LABH3], [RefSeq, PubMed]; Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids., [UniProtKB, PubMed, UniProtKB, UniProtKB]; This study descrbed a cell-based screen for enzyme substrate discovery and its application to identify the protein alpha/beta-hydrolase domain-containing 3 as a lipase that selectively cleaves medium-chain and oxidatively truncated phospholipids. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNF7", "ec_number_list": "1.11.1.27;3.1.1.4;2.3.1.23;3.1.1.5;3.1.1.32;3.1.1.34;3.1.1.3;3.1.2.2;3.1.1.47;2.3.1.-;3.1.1.111;3.1.1.118;3.1.1.-;2.3.1.149;2.3.1.51", "go_molecular_function": "GO:0047372 monoacylglycerol lipase activity;GO:0004623 phospholipase A2 activity;GO:0008970 phospholipase A1 activity;GO:0008126 acetylesterase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0046470 phosphatidylcholine metabolic process;GO:0051793 medium-chain fatty acid catabolic process;GO:0051792 medium-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91ZH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K410-1", "uniprot_id": "ADA32_MOUSE", "mass": 83985.0, "length": 754, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 32", "gene_name": "Adam32", "organism": "Mouse", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 32 isoform 2 precursor", "refseq_ac": "NP_001280622", "gene_names_uniprotkb": "Adam32", "gene_names_refseq": "Adam32", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 32; ADAM 32", "protein_names_refseq": "a disintegrin and metalloprotease domain 32; disintegrin and metalloproteinase domain-containing protein 32 isoform 2 precursor; disintegrin and metalloproteinase domain-containing protein 32", "tax_id": 10090, "disease": "", "pathway": " (mmu:353188)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12568724;20945367;21750661;32972883", "class_list": "", "function": "May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein., [UniProtKB]; Normal fertility in male mice lacking ADAM32 with testis-specific expression., [RefSeq, PubMed]; This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene was found to be expressed predominantly in the pachytene spermatocytes, where the processed protein is localized to the sperm surface. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6P901;Q8BJ80", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0097228 sperm principal piece;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0007339 binding of sperm to zona pellucida;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K410-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UUE9-1", "uniprot_id": "ANKUB_MOUSE", "mass": 22006.0, "length": 192, "protein_name": "Protein ANKUB1", "gene_name": "Ankub1", "organism": "Mouse", "refseq_name": "protein ANKUB1 isoform 2", "refseq_ac": "NP_001028521", "gene_names_uniprotkb": "Ankub1; Gm410", "gene_names_refseq": "Ankub1; Gm410", "protein_names_uniprotkb": "Protein ANKUB1; Ankyrin repeat and ubiquitin domain-containing 1", "protein_names_refseq": "ankrin repeat and ubiquitin domain containing 1; protein ANKUB1 isoform 2; protein ANKUB1", "tax_id": 10090, "disease": "", "pathway": " (mmu:242037)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UUE9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0L3-1", "uniprot_id": "ACSM2_MOUSE", "mass": 64269.0, "length": 575, "protein_name": "Acyl-coenzyme A synthetase ACSM2, mitochondrial", "gene_name": "Acsm2", "organism": "Mouse", "refseq_name": "acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 1", "refseq_ac": "NP_001171448", "gene_names_uniprotkb": "Acsm2", "gene_names_refseq": "Acsm2", "protein_names_uniprotkb": "Acyl-coenzyme A synthetase ACSM2, mitochondrial; 6.2.1.25; 6.2.1.2; Acyl-CoA synthetase medium-chain family member 2; Benzoate--CoA ligase; Butyrate--CoA ligase 2; Butyryl-coenzyme A synthetase 2; Middle-chain acyl-CoA synthetase 2", "protein_names_refseq": "acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 1; acyl-coenzyme A synthetase ACSM2, mitochondrial; benzoate--CoA ligase; butyrate--CoA ligase 2; butyryl-coenzyme A synthetase 2; middle-chain acyl-CoA synthetase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:233799); (R-MMU-177128); (R-MMU-177135); (R-MMU-177162); (R-MMU-9749641)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "19372376;21750661;30084848;32830538", "class_list": "", "function": "Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (By similarity)., [UniProtKB, UniProtKB]; Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells., [RefSeq, PubMed]; Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~50%., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNC6;Q3US47;Q8R1L3;Q96LX4", "ec_number_list": "6.2.1.1;6.2.1.17;6.2.1.2;6.2.1.25;6.2.1.3;6.2.1.15", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0102391 decanoate-CoA ligase activity;GO:0004321 fatty-acyl-CoA synthase activity;GO:0015645 fatty acid ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K0L3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R210-1", "uniprot_id": "TFEB_MOUSE", "mass": 52614.0, "length": 475, "protein_name": "Transcription factor EB", "gene_name": "Tfeb", "organism": "Mouse", "refseq_name": "transcription factor EB", "refseq_ac": "NP_001155194", "gene_names_uniprotkb": "Tfeb; Tcfeb", "gene_names_refseq": "Tcfeb; Tfeb; bHLHe35", "protein_names_uniprotkb": "Transcription factor EB", "protein_names_refseq": "transcription factor EB", "tax_id": 10090, "disease": "lysosomal storage disease (Disease Ontology:DOID:3211)", "pathway": " (mmu:21425)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10036191;16936731;17242355;19144319;21183079;21750661;22343943;24882217;25428506;27184844;27278822;29146937;31219806;32612235;34203471;34428180;35662396;36210013;9806910", "class_list": "", "function": "Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:16936731, PubMed:22343943, PubMed:27278822, PubMed:35662396). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:16936731, PubMed:27278822). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:35662396). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (By similarity). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (By similarity). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (PubMed:16936731). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (By similarity). Plays a role in the signal transduction processes required for normal vascularization of the placenta (PubMed:9806910). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica (PubMed:24882217, PubMed:27184844, PubMed:35662396). Infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding;GO:0046982 protein heterodimerization activity;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050829 defense response to Gram-negative bacterium;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9R210-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2MKA5-1", "uniprot_id": "ACHA5_MOUSE", "mass": 53448.0, "length": 467, "protein_name": "Neuronal acetylcholine receptor subunit alpha-5", "gene_name": "Chrna5", "organism": "Mouse", "refseq_name": "neuronal acetylcholine receptor subunit alpha-5 isoform 2", "refseq_ac": "NP_789814", "gene_names_uniprotkb": "Chrna5", "gene_names_refseq": "Acra-5; Acra5; Chrna5", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-5", "protein_names_refseq": "neuronal acetylcholine receptor subunit alpha-5 isoform 2; neuronal acetylcholine receptor subunit alpha-5; nicotinic acetylcholine receptor alpha5 subunit", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); lung cancer (Disease Ontology:DOID:1324); alcohol use disorder (Disease Ontology:DOID:1574); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); congenital myasthenic syndrome (Disease Ontology:DOID:3635); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); lung large cell carcinoma (Disease Ontology:DOID:4556); lung small cell carcinoma (Disease Ontology:DOID:5409); cocaine abuse (Disease Ontology:DOID:809); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:110835); (R-MMU-629594); (R-MMU-629597)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21555077;21750661;35973602;37116611", "class_list": "", "function": "A common SNP in Chrna5 enhances morphine reward in female mice., [RefSeq, PubMed]; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB, PubMed]; CHRNA5 gene variation affects the response of VTA dopaminergic neurons during chronic nicotine exposure and withdrawal., [RefSeq, PubMed]; Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:21555077). Has an accessory rather than functional role and is only able to form functional nAChRs when co-assembled with another beta subunit. Participates in pentameric assemblies along with CHRNA3, CHRNA4, CHRNB2 and CHRNB4. Increases receptor sensitivity to acetylcholine and nicotine when associated with CHRNA4 and CHRNB2. Plays a role in nicotine addiction (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6PW45", "ec_number_list": "1.8.-.-;2.7.11.1", "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0042166 acetylcholine binding;GO:0044877 protein-containing complex binding;GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0035094 response to nicotine;GO:0035095 behavioral response to nicotine;GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q2MKA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08739-1", "uniprot_id": "AMPD3_MOUSE", "mass": 88652.0, "length": 766, "protein_name": "AMP deaminase 3", "gene_name": "Ampd3", "organism": "Mouse", "refseq_name": "AMP deaminase 3 isoform 1", "refseq_ac": "NP_001263230", "gene_names_uniprotkb": "Ampd3", "gene_names_refseq": "Ampd3", "protein_names_uniprotkb": "AMP deaminase 3; 3.5.4.6; AMP deaminase H-type; AMP deaminase isoform E; Heart-type AMPD", "protein_names_refseq": "AMP deaminase 3 isoform 1; AMP deaminase 3; AMP deaminase H-type; heart-type AMPD", "tax_id": 10090, "disease": "pontocerebellar hypoplasia (Disease Ontology:DOID:0060264)", "pathway": " (mmu:11717); (R-MMU-6798695); (R-MMU-74217)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "17384464;20173027;21750661;30084848;31219806;32761233;34428180;36210013;37725437;9133604;9321472", "class_list": "", "function": "AMP deaminase plays a critical role in energy metabolism., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Adenosine monophosphate deaminase 3 null mutation causes reduction of naive T cells in mouse peripheral blood., [RefSeq, PubMed]; Along with the activation of AMPD3, ischemia-reperfusion-induced lung inflammation is associated with increased MPO activity and TNF-alpha level., [RefSeq, PubMed]; Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic Hypoxia Sensor and Energy Regulator Combating CKD in a Mouse Model., [RefSeq, PubMed]; This gene encodes a member of the adenosine and AMP deaminases family. The encoded protein is an AMP deaminase involved in nucleotide and energy metabolism in erythrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88692;Q8CFR4", "ec_number_list": "2.4.1.25;3.2.1.33;3.5.4.6;1.11.1.24;3.4.22.52;3.4.19.12;3.4.22.27;1.1.1.42;3.4.21.46;4.1.2.13;5.3.1.9;5.1.3.-;3.6.4.10;2.4.2.7;1.16.3.1;3.6.5.-;4.2.1.24;3.4.22.1;3.2.1.31;2.7.1.11;2.7.10.2;5.2.1.8;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;5.3.2.1;5.3.3.12;3.4.24.35;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;1.11.1.7;3.1.6.12;2.7.11.1;2.7.1.40;3.5.4.5;3.4.25.1;2.7.11.39;2.7.4.6;2.7.13.3;3.6.4.6;2.7.1.1;2.7.1.-;3.1.1.47;3.6.4.13;2.7.11.22;2.7.11.23;2.3.2.26;5.4.2.2;5.4.2.7;2.3.2.27;3.1.6.14;2.7.1.35;3.4.19.1;3.6.1.6;2.3.3.8;4.1.2.4;2.3.2.5;5.4.2.11;5.4.2.4;2.4.1.1;2.4.1.186;3.4.18.1;3.5.1.23;3.5.1.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003876 AMP deaminase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0046033 AMP metabolic process;GO:0046032 ADP catabolic process;GO:0097009 energy homeostasis;GO:0006196 AMP catabolic process;GO:0006188 IMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O08739-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02716-1", "uniprot_id": "ACHD_MOUSE", "mass": 59143.0, "length": 520, "protein_name": "Acetylcholine receptor subunit delta", "gene_name": "Chrnd", "organism": "Mouse", "refseq_name": "acetylcholine receptor subunit delta precursor", "refseq_ac": "NP_067611", "gene_names_uniprotkb": "Chrnd; Acrd", "gene_names_refseq": "Achr-4; Acrd; Chrnd", "protein_names_uniprotkb": "Acetylcholine receptor subunit delta", "protein_names_refseq": "AChR delta subunit; acetylcholine receptor subunit delta precursor; acetylcholine receptor subunit delta", "tax_id": 10090, "disease": "congenital myasthenic syndrome 3C (Disease Ontology:DOID:0110664); congenital myasthenic syndrome 3B (Disease Ontology:DOID:0110665); congenital myasthenic syndrome 3A (Disease Ontology:DOID:0110666)", "pathway": " (mmu:11447); (R-MMU-629587)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21750661;24240098;3198687;3244354;6096870;7594562;8227327", "class_list": "", "function": "After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB]; These findings identify novel Golgi retention signals in the beta and delta subunit loops that regulate surface trafficking of assembled AChR and may help prevent surface expression of unassembled subunits., [RefSeq, PubMed]; This gene encodes the delta subunit of the muscle-derived nicotinic acetylcholine receptor, a pentameric neurotransmitter receptor and member of the ligand-gated ion channel superfamily. The delta subunit together with the alpha subunit forms the ligand-binding site. [provided by RefSeq, Nov 2012]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q61267", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0031594 neuromuscular junction;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0042391 regulation of membrane potential;GO:0048630 skeletal muscle tissue growth;GO:0050881 musculoskeletal movement;GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P02716-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60612-1", "uniprot_id": "AA1R_MOUSE", "mass": 36638.0, "length": 326, "protein_name": "Adenosine receptor A1", "gene_name": "Adora1", "organism": "Mouse", "refseq_name": "adenosine receptor A1 isoform a", "refseq_ac": "NP_001008533", "gene_names_uniprotkb": "Adora1", "gene_names_refseq": "A1-AR; A1AR; A1R; AA1R; ARA1; Adora1; Ri", "protein_names_uniprotkb": "Adenosine receptor A1", "protein_names_refseq": "adenosine receptor A1 isoform a; adenosine receptor A1", "tax_id": 10090, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); left ventricular failure (Disease Ontology:DOID:0051064); hypertension (Disease Ontology:DOID:10763); asthma (Disease Ontology:DOID:2841); cerebral infarction (Disease Ontology:DOID:3526); lung disease (Disease Ontology:DOID:850); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11539); (R-MMU-417973); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10318839;21750661;35820727;38619745;39182270;8157966", "class_list": "", "function": "Endothelial alpha1-adrenergic receptor activation improves cardiac function in septic mice via PKC-ERK/p38MAPK signaling pathway., [RefSeq, PubMed]; Intrinsic ecto-5'-Nucleotidase/A1R Coupling may Confer Neuroprotection to the Cerebellum in Experimental Autoimmune Encephalomyelitis., [RefSeq, PubMed]; Receptor for adenosine. The activity of this receptor is mediated by G proteins such as GNAI2 which inhibit adenylyl cyclase (By similarity)., [UniProtKB, UniProtKB]; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGU7;Q9WUF9", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0001609 G protein-coupled adenosine receptor activity;GO:0001664 G protein-coupled receptor binding;GO:0001883 purine nucleoside binding;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0042321 negative regulation of circadian sleep/wake cycle, sleep;GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0001659 temperature homeostasis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q60612-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22599-1", "uniprot_id": "A1AT2_MOUSE", "mass": 45975.0, "length": 413, "protein_name": "Alpha-1-antitrypsin 1-2", "gene_name": "Serpina1b", "organism": "Mouse", "refseq_name": "alpha-1-antitrypsin 1-2 precursor", "refseq_ac": "NP_033270", "gene_names_uniprotkb": "Serpina1b; Aat2; Dom2; Spi1-2", "gene_names_refseq": "D12Ucla2; Dom2; PI2; Serpina1b; Spi1-2", "protein_names_uniprotkb": "Alpha-1-antitrypsin 1-2; AAT; Alpha-1 protease inhibitor 2; Alpha-1-antiproteinase; Serine protease inhibitor 1-2; Serine protease inhibitor A1b; Serpin A1b", "protein_names_refseq": "AAT; alpha-1 protease inhibitor 2; alpha-1-antiproteinase; alpha-1-antitrypsin 1-2 precursor; alpha-1-antitrypsin 1-2; serine (or cysteine) proteinase inhibitor, clade A, member 1b; serine protease inhibitor 1-2; serine protease inhibitor A1b; serpin A1b", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); chemical colitis (Disease Ontology:DOID:0060186); ileitis (Disease Ontology:DOID:0060189); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); pancreatic cancer (Disease Ontology:DOID:1793); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); acute pancreatitis (Disease Ontology:DOID:2913); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); liver disease (Disease Ontology:DOID:409); primary hyperaldosteronism (Disease Ontology:DOID:446); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); proteinuria (Disease Ontology:DOID:576); pulmonary hypertension (Disease Ontology:DOID:6432); osteoarthritis (Disease Ontology:DOID:8398); colorectal cancer (Disease Ontology:DOID:9256); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:20701)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11961105;12408969;12659817;16944957;1946354;20571061;20971880;21750661;2303252;26495903;26740625;39627609;40997131;8619829", "class_list": "", "function": "Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin., [UniProtKB, PubMed, PubMed]; Loss of alpha 1-Antitrypsin is associated with emphysema., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 23, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q61283;Q80ZH5;Q8VC20", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0042802 identical protein binding;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0010288 response to lead ion;GO:0006953 acute-phase response;GO:0034097 response to cytokine;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P22599-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07758-1", "uniprot_id": "A1AT1_MOUSE", "mass": 46003.0, "length": 413, "protein_name": "Alpha-1-antitrypsin 1-1", "gene_name": "Serpina1a", "organism": "Mouse", "refseq_name": "alpha-1-antitrypsin 1-1 isoform 1 precursor", "refseq_ac": "NP_033269", "gene_names_uniprotkb": "Serpina1a; Dom1; Spi1-1", "gene_names_refseq": "Aat-2; Aat2; Dom1; PI1; Serpina1a; Spi1-1; Spi1-3", "protein_names_uniprotkb": "Alpha-1-antitrypsin 1-1; AAT; Alpha-1 protease inhibitor 1; Alpha-1-antiproteinase; Serine protease inhibitor 1-1; Serine protease inhibitor A1a; Serpin A1a", "protein_names_refseq": "AAT; alpha-1 protease inhibitor 1; alpha-1-antiproteinase; alpha-1-antitrypsin 1-1 isoform 1 precursor; alpha-1-antitrypsin 1-1; alpha-1-antitrypsin 2; serine (or cysteine) proteinase inhibitor, clade A, member 1a; serine protease inhibitor 1-1; serine protease inhibitor A1a; serpin A1a", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); chemical colitis (Disease Ontology:DOID:0060186); ileitis (Disease Ontology:DOID:0060189); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); pancreatic cancer (Disease Ontology:DOID:1793); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); acute pancreatitis (Disease Ontology:DOID:2913); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); liver disease (Disease Ontology:DOID:409); primary hyperaldosteronism (Disease Ontology:DOID:446); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); proteinuria (Disease Ontology:DOID:576); pulmonary hypertension (Disease Ontology:DOID:6432); osteoarthritis (Disease Ontology:DOID:8398); colorectal cancer (Disease Ontology:DOID:9256); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:20700)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11961105;12408969;12659817;17330941;1946354;21750661;23386199;3007061;34105348;34192300;34428180;36142337;37394797;38108976;38285890;39627609;39927985;8619829", "class_list": "", "function": "Increased expression or activation of TRPML1 reduces hepatic storage of toxic Z alpha-1 antitrypsin., [RefSeq, PubMed]; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin., [UniProtKB, PubMed, PubMed]; Lipoproteins in Negative Feedback with Alpha-1 Antitrypsin., [RefSeq, PubMed]; Loss of Serpina1 in Mice Leads to Altered Gene Expression in Inflammatory and Metabolic Pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Placental HTRA1 cleaves alpha1-antitrypsin to generate a NET-inhibitory peptide., [RefSeq, PubMed]; Sirtuin3 promotes the degradation of hepatic Z alpha-1 antitrypsin through lipophagy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 23, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJ47;Q80YB8;Q8JZV6;Q91XB8", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0042802 identical protein binding;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix", "go_biological_process": "GO:0010288 response to lead ion;GO:0006953 acute-phase response;GO:0034097 response to cytokine;GO:0006487 protein N-linked glycosylation;GO:0043434 response to peptide hormone", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P07758-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PD03-1", "uniprot_id": "2A5A_MOUSE", "mass": 56347.0, "length": 486, "protein_name": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform", "gene_name": "Ppp2r5a", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform", "refseq_ac": "NP_659129", "gene_names_uniprotkb": "Ppp2r5a", "gene_names_refseq": "PR61alpha; Ppp2r5a", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; PP2A B subunit isoform B'-alpha; PP2A B subunit isoform B56-alpha; PP2A B subunit isoform PR61-alpha; PP2A B subunit isoform R5-alpha; PR61alpha", "protein_names_refseq": "serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:226849); (R-MMU-141430); (R-MMU-141444); (R-MMU-195253); (R-MMU-196299); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-389356); (R-MMU-389513); (R-MMU-432142); (R-MMU-4641262); (R-MMU-5663220); (R-MMU-5673000); (R-MMU-5675221); (R-MMU-6811558); (R-MMU-68877); (R-MMU-9648025); (R-MMU-9833482)", "pathway_count": 18, "publication_count": 7, "publication_id_list": "15095873;19201758;21750661;22872234;25605945;34428180;36210013", "class_list": "", "function": "Protein phosphatase 2A contributes to the cardiac dysfunction induced by endotoxemia., [RefSeq, PubMed]; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1U7", "ec_number_list": "", "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0019900 kinase binding;GO:0072542 protein phosphatase activator activity;GO:0019210 kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:1903077 negative regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6PD03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56473-1", "uniprot_id": "AGRP_MOUSE", "mass": 14432.0, "length": 131, "protein_name": "Agouti-related protein", "gene_name": "Agrp", "organism": "Mouse", "refseq_name": "agouti-related protein precursor", "refseq_ac": "NP_001258735", "gene_names_uniprotkb": "Agrp; Agrt; Art", "gene_names_refseq": "Agrp; Agrt; Art", "protein_names_uniprotkb": "Agouti-related protein", "protein_names_refseq": "agouti-related protein precursor; agouti-related protein; orexigenic neuropeptide", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11604)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;9119224;9311920;9892020", "class_list": "", "function": "Signaling protein that functions as an antagonist of melanocyte-stimulating-hormone receptors MC3R and MC4R by precluding agonist-induced signaling, thereby inhibiting cAMP production within the hypothalamus and adrenal gland. Involved in the control of feeding behavior via the central melanocortin system. Has very low activity towards MC5R. Also promotes endocytosis of MC3R and MC4R in an arrestin-dependent mechanism., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; This gene encodes a protein that regulates feeding behavior and plays a key role in the control of body weight. The encoded protein acts as an antagonist of melanocortin receptor signaling. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2012]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35967", "ec_number_list": "", "go_molecular_function": "GO:0048019 receptor antagonist activity;GO:0005184 neuropeptide hormone activity;GO:0031781 type 3 melanocortin receptor binding;GO:0031782 type 4 melanocortin receptor binding;GO:0070996 type 1 melanocortin receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005796 Golgi lumen;GO:0043025 neuronal cell body", "go_biological_process": "GO:0032100 positive regulation of appetite;GO:1904000 positive regulation of eating behavior;GO:0007218 neuropeptide signaling pathway;GO:0032098 regulation of appetite;GO:0042755 eating behavior", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P56473-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG02-1", "uniprot_id": "2ABG_MOUSE", "mass": 51462.0, "length": 447, "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform", "gene_name": "Ppp2r2c", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 1", "refseq_ac": "NP_766582", "gene_names_uniprotkb": "Ppp2r2c", "gene_names_refseq": "6330548O06Rik; IMYPNO1; IMYPNO; PR52; Ppp2r2c", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform; PP2A subunit B isoform B55-gamma; PP2A subunit B isoform PR55-gamma; PP2A subunit B isoform R2-gamma; PP2A subunit B isoform gamma", "protein_names_refseq": "serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 1", "tax_id": 10090, "disease": "autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441)", "pathway": " (mmu:269643)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;32291379", "class_list": "", "function": "PP2A subunit PPP2R2C is downregulated in the brains of Alzheimer's transgenic mice., [RefSeq, PubMed]; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0051983 regulation of chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BG02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6GQT1-1", "uniprot_id": "A2MG_MOUSE", "mass": 164353.0, "length": 1474, "protein_name": "Alpha-2-macroglobulin-P", "gene_name": "A2m", "organism": "Mouse", "refseq_name": "alpha-2-macroglobulin-P precursor", "refseq_ac": "NP_783327", "gene_names_uniprotkb": "A2m; A2mp", "gene_names_refseq": "A2mp; A2m", "protein_names_uniprotkb": "Alpha-2-macroglobulin-P; Alpha-2-macroglobulin", "protein_names_refseq": "alpha-2-macroglobulin-P precursor; alpha-2-macroglobulin-P", "tax_id": 10090, "disease": "hepatocellular adenoma (Disease Ontology:DOID:0050868); COVID-19 (Disease Ontology:DOID:0080600); trypanosomiasis (Disease Ontology:DOID:10113); osteonecrosis (Disease Ontology:DOID:10159); Alzheimer's disease (Disease Ontology:DOID:10652); membranous glomerulonephritis (Disease Ontology:DOID:10976); heart disease (Disease Ontology:DOID:114); nephrotic syndrome (Disease Ontology:DOID:1184); background diabetic retinopathy (Disease Ontology:DOID:13208); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); obstructive lung disease (Disease Ontology:DOID:2320); multiple sclerosis (Disease Ontology:DOID:2377); cerebral infarction (Disease Ontology:DOID:3526); hemolytic anemia (Disease Ontology:DOID:583); hepatocellular carcinoma (Disease Ontology:DOID:684); peritonitis (Disease Ontology:DOID:8283)", "pathway": " (mmu:232345); (R-MMU-114608); (R-MMU-1474228); (R-MMU-8963896); (R-MMU-9855719)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;15355875;21750661;31219806;34105348;34418053;35820727;37828378", "class_list": "", "function": "Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 17, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "E9QMQ7;Q811S0", "ec_number_list": "", "go_molecular_function": "GO:0048406 nerve growth factor binding;GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005102 signaling receptor binding;GO:0019838 growth factor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001869 negative regulation of complement activation, lectin pathway;GO:0048863 stem cell differentiation;GO:0007565 female pregnancy;GO:0010951 negative regulation of endopeptidase activity", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q6GQT1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00896-1", "uniprot_id": "A1AT3_MOUSE", "mass": 45823.0, "length": 412, "protein_name": "Alpha-1-antitrypsin 1-3", "gene_name": "Serpina1c", "organism": "Mouse", "refseq_name": "alpha-1-antitrypsin 1-3 precursor", "refseq_ac": "NP_033271", "gene_names_uniprotkb": "Serpina1c; Dom3; Dom6; Spi1-3; Spi1-6", "gene_names_refseq": "Pi3; Pi6; Serpina1c; Skalp; Spi1-3; Spi1-6; Wap3", "protein_names_uniprotkb": "Alpha-1-antitrypsin 1-3; Alpha-1 protease inhibitor 3; Alpha-1 protease inhibitor 6; Alpha-1-antitrypsin 1-6; Serine protease inhibitor 1-3; Serine protease inhibitor 1-6; Serine protease inhibitor A1c; Serpin A1c", "protein_names_refseq": "alpha-1 protease inhibitor 3; alpha-1 protease inhibitor 6; alpha-1-antitrypsin 1-3 precursor; alpha-1-antitrypsin 1-3; alpha-1-antitrypsin 1-6; apha-1 protease inhibitor 3; pre-elafin; serine (or cysteine) proteinase inhibitor, clade A, member 1c; serine protease inhibitor 1-3; serine protease inhibitor 1-6; serine protease inhibitor A1c; serpin A1c; trappin-2", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); chemical colitis (Disease Ontology:DOID:0060186); ileitis (Disease Ontology:DOID:0060189); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); pancreatic cancer (Disease Ontology:DOID:1793); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); acute pancreatitis (Disease Ontology:DOID:2913); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); liver disease (Disease Ontology:DOID:409); primary hyperaldosteronism (Disease Ontology:DOID:446); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); proteinuria (Disease Ontology:DOID:576); pulmonary hypertension (Disease Ontology:DOID:6432); osteoarthritis (Disease Ontology:DOID:8398); colorectal cancer (Disease Ontology:DOID:9256); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:20702); (R-MMU-114608); (R-MMU-204005); (R-MMU-381426); (R-MMU-5694530); (R-MMU-6798695); (R-MMU-8957275)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "11961105;12659817;16944957;19264904;1946354;21750661;34428180;36583994;37507081;6547997;8619829", "class_list": "", "function": "Inhibitor of serine proteases. Can inhibit trypsin and chymotrypsin; relatively ineffective against elastase., [UniProtKB, PubMed, PubMed]; Trappin-2 may therefore play an important role in innate recognition and clearance of pathogens during the very earliest stages of pulmonary infection., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 23, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P81105;Q91V74;Q91WH5;Q91XC1", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0042802 identical protein binding;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0034097 response to cytokine;GO:0043434 response to peptide hormone", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q00896-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51829-1", "uniprot_id": "ADCY7_MOUSE", "mass": 122708.0, "length": 1099, "protein_name": "Adenylate cyclase type 7", "gene_name": "Adcy7", "organism": "Mouse", "refseq_name": "adenylate cyclase type 7", "refseq_ac": "NP_001032812", "gene_names_uniprotkb": "Adcy7", "gene_names_refseq": "Adcy7", "protein_names_uniprotkb": "Adenylate cyclase type 7; 2.7.7.85; 4.6.1.1; ATP pyrophosphate-lyase 7; Adenylate cyclase type VII; Adenylyl cyclase 7; Cyclic di-AMP synthase ADCY7", "protein_names_refseq": "ATP pyrophosphate-lyase 7; adenylate cyclase type 7; adenylate cyclase type VII; adenylyl cyclase 7; adenylyl cyclase type VII; cyclic di-AMP synthase ADCY7", "tax_id": 10090, "disease": "", "pathway": " (mmu:11513); (R-MMU-163615); (R-MMU-170660); (R-MMU-170670); (R-MMU-418597); (R-MMU-5610787)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "18205980;18541530;20505140;21750661;23178822;23229509;26495903;29187734;31219806;34428180;36613790;40419769;40885482;7961850", "class_list": "", "function": "Adenylate cyclase that mediates formation of both cyclic AMP (cAMP) and cyclic di-AMP (c-di-AMP) (PubMed:18205980, PubMed:23229509, PubMed:40419769). Acts as a key mediator of G protein-coupled receptor signaling by catalyzing the formation of cAMP downstream of G protein-coupled receptors (By similarity). Functions in G protein-coupled receptor signaling cascades activated by thrombin, sphingosine 1-phosphate, dopamine and anaphylatoxin C5a (By similarity). Mediates regulation of cAMP synthesis through synergistic action of the G alpha protein G(s) (GNAS) with G(13) (GNA13) (PubMed:18541530, PubMed:23178822). Also involved in inflammation by acting as a diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into c-di-AMP (PubMed:40419769). Following activation by TLR9, mediates formation of c-di-AMP, which directly activates NLRP3, thereby promoting assembly and maturation of the NLRP3 inflammasome (PubMed:40419769). It is also required for the optimal functions of B- and T cells during adaptive immune responses by regulating cAMP synthesis in both B- and T-cells (PubMed:20505140)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Role of Adenylyl Cyclase Type 7 in Functions of BV-2 Microglia. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3P2", "ec_number_list": "3.6.5.-;4.6.1.1;2.7.7.85", "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106408 diadenylate cyclase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190 activation of adenylate cyclase activity;GO:0035556 intracellular signal transduction;GO:0060135 maternal process involved in female pregnancy", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P51829-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2R3-1", "uniprot_id": "AAGAB_MOUSE", "mass": 34511.0, "length": 316, "protein_name": "Alpha- and gamma-adaptin-binding protein p34", "gene_name": "Aagab", "organism": "Mouse", "refseq_name": "alpha- and gamma-adaptin-binding protein p34 isoform 1", "refseq_ac": "NP_080133", "gene_names_uniprotkb": "Aagab", "gene_names_refseq": "2310007F21Rik; Aagab; p34", "protein_names_uniprotkb": "Alpha- and gamma-adaptin-binding protein p34", "protein_names_refseq": "alpha- and gamma-adaptin-binding protein p34 isoform 1; alpha- and gamma-adaptin-binding protein p34", "tax_id": 10090, "disease": "punctate palmoplantar keratoderma type I (Disease Ontology:DOID:0080214)", "pathway": " (mmu:66939)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "May be involved in endocytic recycling of growth factor receptors such as EGFR., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TW04;Q9CV78", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R2R3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4G9-1", "uniprot_id": "ACHA3_MOUSE", "mass": 57110.0, "length": 499, "protein_name": "Neuronal acetylcholine receptor subunit alpha-3", "gene_name": "Chrna3", "organism": "Mouse", "refseq_name": "neuronal acetylcholine receptor subunit alpha-3 precursor", "refseq_ac": "NP_660111", "gene_names_uniprotkb": "Chrna3", "gene_names_refseq": "(a)3; A730007P14Rik; Acra-3; Acra3; Chrna3", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-3", "protein_names_refseq": "neuronal acetylcholine receptor subunit alpha-3 precursor; neuronal acetylcholine receptor subunit alpha-3; neuronal nicotinic acetylcholine receptor, alpha 3 subunit", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); depressive disorder (Disease Ontology:DOID:1596); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:110834); (R-MMU-629587); (R-MMU-629594); (R-MMU-629597)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "19474315;21555077;21659607;21750661;33380469;34203471;37879250;38902419", "class_list": "", "function": "Abundant extrasynaptic expression of alpha3beta4-containing nicotinic acetylcholine receptors in the medial habenula-interpeduncular nucleus pathway in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Alpha3* Nicotinic Acetylcholine Receptors in the Habenula-Interpeduncular Nucleus Circuit Regulate Nicotine Intake., [RefSeq, PubMed]; Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:21555077). CHRNA3 forms heteropentameric neuronal acetylcholine receptors with CHRNA5, CHRNB2 and CHRNB4 (PubMed:21555077). CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor (By similarity). CHRNA3:CHRNB4 or CHRNA3:CHRNA5:CHRNB4 play also an important role in the habenulo-interpeduncular tract, modulating the mesolimbic dopamine system and affecting reward circuits and addiction (PubMed:21555077). Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (PubMed:21659607). Also expressed in the urothelium where it modulates reflex bladder activity by increasing intracellular calcium through extracellular influx and basal ATP release (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Differential tyrosine and serine/threonine phosphorylation/dephosphorylation pathways regulate the expression of alpha7 versus alpha3beta4 nicotinic receptor subtypes in mouse hippocampal neurons., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BV44", "ec_number_list": "1.8.-.-;2.7.11.1", "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0042166 acetylcholine binding;GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006940 regulation of smooth muscle contraction;GO:0007165 signal transduction;GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity;GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R4G9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60613-1", "uniprot_id": "AA2AR_MOUSE", "mass": 44971.0, "length": 410, "protein_name": "Adenosine receptor A2a", "gene_name": "Adora2a", "organism": "Mouse", "refseq_name": "adenosine receptor A2a isoform a", "refseq_ac": "NP_001318024", "gene_names_uniprotkb": "Adora2a", "gene_names_refseq": "A2AAR; A2aR; AA2AR; ARA2A; Adora2a", "protein_names_uniprotkb": "Adenosine receptor A2a", "protein_names_refseq": "adenosine receptor A2a isoform a; adenosine receptor A2a", "tax_id": 10090, "disease": "myopia (Disease Ontology:DOID:11830); primary pulmonary hypertension (Disease Ontology:DOID:14557); asthma (Disease Ontology:DOID:2841); lung disease (Disease Ontology:DOID:850)", "pathway": " (mmu:11540); (R-MMU-417973); (R-MMU-418555); (R-MMU-5683826)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "21750661;23994616;8157966;9262401", "class_list": "", "function": "Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity)., [UniProtKB, UniProtKB]; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q2NLC1", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0001609 G protein-coupled adenosine receptor activity;GO:0031802 type 5 metabotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0043279 response to alkaloid;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007271 synaptic transmission, cholinergic;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q60613-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PAT0-1", "uniprot_id": "ADAT3_MOUSE", "mass": 37517.0, "length": 349, "protein_name": "tRNA-specific adenosine-34 deaminase regulatory subunit ADAT3", "gene_name": "Adat3", "organism": "Mouse", "refseq_name": "tRNA-specific adenosine-34 deaminase regulatory subunit ADAT3", "refseq_ac": "NP_001094076", "gene_names_uniprotkb": "Adat3", "gene_names_refseq": "A430024H01Rik; Adat3", "protein_names_uniprotkb": "tRNA-specific adenosine-34 deaminase regulatory subunit ADAT3", "protein_names_refseq": "adenosine deaminase, tRNA-specific 3, TAD2 homolog; probable inactive tRNA-specific adenosine deaminase-like protein 3; tRNA-specific adenosine deaminase 3; tRNA-specific adenosine deaminase-like protein 3; tRNA-specific adenosine-34 deaminase regulatory subunit ADAT3; tRNA-specific adenosine-34 deaminase subunit ADAT3", "tax_id": 10090, "disease": "neurodevelopmental disorder with brain abnormalities, poor growth, and dysmorphic facies (Disease Ontology:DOID:0081099)", "pathway": " (mmu:100113398)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;34057470;40120092", "class_list": "", "function": "Non-catalytic subunit of the tRNA-specific adenosine-34 deaminase complex, composed of the ADAT2 catalytic subunit and the ADAT3 regulatory subunit, which deaminates adenosine-34 (the first, also called wobble position of the anticodon) to inosine in many tRNAs (PubMed:34057470). Inosine-34 allows the decoding of 3 different nucleotides at the third position of mRNA codons, as inosine is able to pair with U, C, and A (PubMed:34057470). Required for binding of the ADAT2-ADAT3 complex to tRNA through its N-terminus, which rotates with respect to the catalytic domain of the complex, formed by ADAT2 and the ADAT3 C-terminal domain, to position the tRNA anticodon stem-loop correctly in the ADAT2 active site (PubMed:34057470). The ADAT2-ADAT3 complex is required for radial migration of projection neurons in the developing brain cortex, and the catalytic activity of the complex is necessary for this function (PubMed:40120092)., [UniProtKB, PubMed, PubMed]; The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PAT0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41234-1", "uniprot_id": "ABCA2_MOUSE", "mass": 270509.0, "length": 2434, "protein_name": "ATP-binding cassette sub-family A member 2", "gene_name": "Abca2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Abca2; Abc2", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP-binding cassette sub-family A member 2; 7.6.2.-; ATP-binding cassette 2; ATP-binding cassette transporter 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-1369062)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11157071;16075062;17060448;17488728;19144319;21183079;21750661;22086926;22748276;25428506;30084848;30779550;30899004;31219806;33300544;34203471;34428180;8088782", "class_list": "", "function": "Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (PubMed:17488728, PubMed:22748276). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (By similarity). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926). May play a role in myelin formation (PubMed:17060448)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 12, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 12, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 12, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 12, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 0, "glyco_site_count": 25, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.-", "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0099038 ceramide floppase activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0032289 central nervous system myelin formation;GO:0006869 lipid transport;GO:0007626 locomotory behavior;GO:1902004 positive regulation of amyloid-beta formation;GO:0046512 sphingosine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "P41234-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AKK5-1", "uniprot_id": "ACNT1_MOUSE", "mass": 46071.0, "length": 416, "protein_name": "Acyl-coenzyme A amino acid N-acyltransferase 1", "gene_name": "Acnat1", "organism": "Mouse", "refseq_name": "acyl-coenzyme A amino acid N-acyltransferase 1", "refseq_ac": "NP_001158037", "gene_names_uniprotkb": "Acnat1", "gene_names_refseq": "Acnat1", "protein_names_uniprotkb": "Acyl-coenzyme A amino acid N-acyltransferase 1; 2.3.1.-", "protein_names_refseq": "acyl-coenzyme A amino acid N-acyltransferase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:230161)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17116739;21750661", "class_list": "", "function": "Acyltransferase which efficiently conjugates very long-chain and long-chain fatty acids to taurine (PubMed:17116739). Shows no conjugation activity in the presence of glycine (PubMed:17116739)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AKK4;Q0QBA1", "ec_number_list": "2.3.1.-", "go_molecular_function": "GO:0047617 fatty acyl-CoA hydrolase activity;GO:0016410 N-acyltransferase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2AKK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97714-1", "uniprot_id": "ADA1D_MOUSE", "mass": 59858.0, "length": 562, "protein_name": "Alpha-1D adrenergic receptor", "gene_name": "Adra1d", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Adra1d; Adra1a; Gpcr8", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-1D adrenergic receptor; Alpha-1A adrenergic receptor; Alpha-1D adrenoceptor; Alpha-1D adrenoreceptor", "protein_names_refseq": "", "tax_id": 10090, "disease": "polycystic ovary syndrome (Disease Ontology:DOID:11612)", "pathway": " (mmu:11550); (R-MMU-390696); (R-MMU-416476); (R-MMU-416482)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10622215;21750661;26715683;7595531;8288218", "class_list": "", "function": "Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1D binds the catecholamine ligands norepinephrine and epinephrine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q61619", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004937 alpha1-adrenergic receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007267 cell-cell signaling;GO:0043410 positive regulation of MAPK cascade;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0008217 regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P97714-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34968-1", "uniprot_id": "5HT2C_MOUSE", "mass": 51929.0, "length": 459, "protein_name": "5-hydroxytryptamine receptor 2C", "gene_name": "Htr2c", "organism": "Mouse", "refseq_name": "5-hydroxytryptamine receptor 2C isoform 1 precursor", "refseq_ac": "NP_032338", "gene_names_uniprotkb": "Htr2c; 5ht1c; Htr1c", "gene_names_refseq": "5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HT2cR; 5-HTR2C; 5HT1c; Htr1c; Htr2c; SR1", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 2C; 5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HTR2C; 5-hydroxytryptamine receptor 1C; Serotonin receptor 2C", "protein_names_refseq": "5-HT2C receptor; 5-hydroxytryptamine receptor 1C; 5-hydroxytryptamine receptor 2C isoform 1 precursor; 5-hydroxytryptamine receptor 2C; serotonin receptor 2C", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); Prader-Willi syndrome (Disease Ontology:DOID:11983); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); anxiety disorder (Disease Ontology:DOID:2030); asthma (Disease Ontology:DOID:2841); substance-related disorder (Disease Ontology:DOID:303); bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419); cocaine abuse (Disease Ontology:DOID:809); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:15560); (R-MMU-390666); (R-MMU-416476)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "1381232;1661811;16904273;16914526;17451451;17596444;19038216;19501602;21037584;21048120;21750661;21835345;7700379;9771748", "class_list": "", "function": "Differences between strains were found in total editing frequency, in the proportion of transcripts with 1 and 4 edited sites, in editing frequency at the A, B, E and D sites, in amino acid frequencies at positions 157 and 161, and in protein isoforms., [RefSeq, PubMed]; G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:17596444). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). HTR2C is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (By similarity). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (By similarity). Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelanocortin neurons and the release of CRH that then regulates the release of corticosterone (PubMed:19038216, PubMed:21037584, PubMed:21835345). Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress (PubMed:17451451, PubMed:21048120, PubMed:7700379). Plays a role in insulin sensitivity and glucose homeostasis (PubMed:21037584, PubMed:9771748)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B1ATN5;Q5WRU6", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0001587 Gq/11-coupled serotonin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030425 dendrite;GO:0045202 synapse;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007626 locomotory behavior;GO:0035095 behavioral response to nicotine;GO:0045600 positive regulation of fat cell differentiation;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P34968-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08915-1", "uniprot_id": "AIP_MOUSE", "mass": 37605.0, "length": 330, "protein_name": "AH receptor-interacting protein", "gene_name": "Aip", "organism": "Mouse", "refseq_name": "AH receptor-interacting protein", "refseq_ac": "NP_001263213", "gene_names_uniprotkb": "Aip", "gene_names_refseq": "Aip; Ara9; D19Bwg1412e; Fkbp16; Xap2", "protein_names_uniprotkb": "AH receptor-interacting protein; AIP; Aryl-hydrocarbon receptor-interacting protein", "protein_names_refseq": "AH receptor-interacting protein", "tax_id": 10090, "disease": "pituitary adenoma 1 (Disease Ontology:DOID:0112009)", "pathway": " (mmu:11632)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12431985;12482853;21750661;22645316;24662816;24788674;25153642;25428506;27706259;28135057;28528544;30084848;32821937;32848054;34203471;34428180;34588620;9083006", "class_list": "", "function": "May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting., [UniProtKB]; PPARalpha is in a complex with hsp90 and XAP2, and XAP2 appears to function as a repressor, [RefSeq, PubMed]; Prkar1a haploinsufficiency ameliorates the growth hormone excess phenotype in Aip-deficient mice., [RefSeq, PubMed]; RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas. Erratum:[Oncogene. 2023 Dec;42(49):3655-3656. doi: 10.1038/s41388-023-02862-9. PMID: 37932482], [RefSeq, PubMed]; Results demonstrated that Aip inactivation promoted somatotroph tumorigenesis and overproduction of growth hormone probably through increased Stat3 activation. Publication Status: Online-Only, [RefSeq, PubMed]; Results provide novel evidence that AIP has an important role in the regulation of cAMP synthesis., [RefSeq, PubMed]; This gene encodes an Hsp90-associated protein that is localized to the cytoplasm. The encoded protein interacts with the aryl hydrocarbon receptor (AhR) and the tyrosine kinase receptor RET, inhibits AhR ubiquitination, and regulates the intracellular localization of AhR. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]., [RefSeq]; XAP2 hinders importin beta binding to the mAhR complex and represses the transactivation potential of the AhR by stabilizing the receptor complex and/or blocking nucleocytoplasmic shuttling of the AhR complex, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJM2", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0051082 unfolded protein binding;GO:0017162 aryl hydrocarbon receptor binding;GO:0036004 GAF domain binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0034751 aryl hydrocarbon receptor complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0006626 protein targeting to mitochondrion;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "O08915-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99P81-1", "uniprot_id": "ABCG3_MOUSE", "mass": 73613.0, "length": 650, "protein_name": "ATP-binding cassette sub-family G member 3", "gene_name": "Abcg3", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family G member 3 isoform 1", "refseq_ac": "NP_084515", "gene_names_uniprotkb": "Abcg3", "gene_names_refseq": "Abcg3; Abcp2; Mxr2", "protein_names_uniprotkb": "ATP-binding cassette sub-family G member 3", "protein_names_refseq": "ATP-binding cassette sub-family G member 3 isoform 1; ATP-binding cassette sub-family G member 3; ATP-binding cassette, sub-family G (WHITE), member 3", "tax_id": 10090, "disease": "gout (Disease Ontology:DOID:13189); breast carcinoma (Disease Ontology:DOID:3459); toxic encephalopathy (Disease Ontology:DOID:3602); renal cell carcinoma (Disease Ontology:DOID:4450); B-cell lymphoma (Disease Ontology:DOID:707); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute megakaryocytic leukemia (Disease Ontology:DOID:8761); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:27405)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11178751;19224205;20173027;21750661;21952136;25605945;30084848;30779550;31219806;34428180", "class_list": "", "function": "The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It lacks several highly conserved residues found in other ATP-binding proteins; this suggests that this protein may not bind ATP and may require dimerization with another subunit to form a functional ATP-transporter. The function of this gene has not yet been determined; however, high levels of expression in the thymus and spleen suggest a potential role in the transport of specific peptides or hydrophobic compounds from lymphocytes. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKI5", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0031526 brush border membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0046415 urate metabolic process;GO:0070633 transepithelial transport;GO:0032218 riboflavin transport;GO:1990962 xenobiotic transport across blood-brain barrier", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99P81-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D099-1", "uniprot_id": "ACER3_MOUSE", "mass": 31565.0, "length": 267, "protein_name": "Alkaline ceramidase 3", "gene_name": "Acer3", "organism": "Mouse", "refseq_name": "alkaline ceramidase 3 isoform 1", "refseq_ac": "NP_079684", "gene_names_uniprotkb": "Acer3; Aphc; Phca", "gene_names_refseq": "1110057L18Rik; 5430429L08Rik; Acer3; Phca; aPHC", "protein_names_uniprotkb": "Alkaline ceramidase 3; 3.5.1.-; 3.5.1.23; AlkCDase 3; Alkaline CDase 3; Alkaline phytoceramidase; aPHC", "protein_names_refseq": "alkCDase 3; alkaline CDase 3; alkaline ceramidase 3 isoform 1; alkaline phytoceramidase; phytoceramidase, alkaline", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); leukodystrophy (Disease Ontology:DOID:10579); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:66190); (R-MMU-9845614)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;26474409;26938296;31949129", "class_list": "glycogene", "function": "Acer3 plays critically protective roles in controlling the homeostasis of various sphingolipids, including ceramides, sphingosine, S1P, and certain complex sphingolipids in the brain and protects Purkinje cells from premature degeneration. Erratum:[PLoS Genet. 2018 Jan 23;14(1):e1007190. doi: 10.1371/journal.pgen.1007190. PMID: 29360825] Publication Status: Online-Only, [RefSeq, PubMed]; Alkaline ceramidase 3 expression has an important role in the innate immune response by regulating the expression of pro-inflammatory cytokines in cells of the innate immune system through C18:1-ceramide. Publication Status: Online-Only, [RefSeq, PubMed]; Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:26474409). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:26474409). Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma (By similarity). Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function (PubMed:26474409). By regulating the levels of pro-inflammatory ceramides in immune cells and tissues, may modulate the inflammatory response (PubMed:26938296)., [UniProtKB, UniProtKB, PubMed, PubMed]; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress. Erratum:[Cell Death Dis. 2020 Mar 17;11(3):191. doi: 10.1038/s41419-020-2396-1. PMID: 32184395] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q542R2;Q9D0X4;Q9D3J4", "ec_number_list": "3.5.1.23;3.5.1.-;3.5.1.60", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0017040 N-acylsphingosine amidohydrolase activity;GO:0005509 calcium ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0008284 positive regulation of cell population proliferation;GO:0042552 myelination;GO:0046512 sphingosine biosynthetic process;GO:0046514 ceramide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D099-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99PE8-1", "uniprot_id": "ABCG5_MOUSE", "mass": 73244.0, "length": 652, "protein_name": "ATP-binding cassette sub-family G member 5", "gene_name": "Abcg5", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family G member 5", "refseq_ac": "NP_114090", "gene_names_uniprotkb": "Abcg5", "gene_names_refseq": "Abcg5; cmp; sterolin-1; trac", "protein_names_uniprotkb": "ATP-binding cassette sub-family G member 5; 7.6.2.-; Sterolin-1", "protein_names_refseq": "ATP-binding cassette sub-family G member 5; ATP-binding cassette, sub-family G (WHITE), member 5; sterolin 1", "tax_id": 10090, "disease": "sitosterolemia 2 (Disease Ontology:DOID:0060983); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); sitosterolemia (Disease Ontology:DOID:0090019); cholestasis (Disease Ontology:DOID:13580); arteriosclerosis (Disease Ontology:DOID:2349); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:27409); (R-MMU-1369062)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "11099417;11138003;11901146;11907139;12208867;12444248;12777468;12949731;14504269;14657202;15040800;15054092;16352607;16867993;18402465;19846887;21750661;25378657;30084848;34428180;34510707;36839356;39136693", "class_list": "", "function": "ABCG5 and ABCG8 Are Involved in Vitamin K Transport. Publication Status: Online-Only, [RefSeq, PubMed]; ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:16352607, PubMed:16867993, PubMed:18402465). Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:12444248, PubMed:14504269, PubMed:14657202, PubMed:19846887, PubMed:25378657). Required for normal sterol homeostasis (PubMed:12444248, PubMed:14657202). The heterodimer with ABCG8 has ATPase activity (PubMed:16352607, PubMed:16867993)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Although a large number of polymorphic variants were identified, strains reported to show significant differences in cholesterol absorption rates did not show significant genomic variations in Abcg5 or Abcg8., [RefSeq, PubMed]; Disruption in Abcg5 gene is associated with thrombocytopenia and cardiomyopathy., [RefSeq, PubMed]; Maternal high-fat diet regulates offspring hepatic ABCG5 expression and cholesterol metabolism via the gut microbiota and its derived butyrate., [RefSeq, PubMed]; Regulation by liver X receptors alpha and beta, [RefSeq, PubMed]; The Complex ABCG5/ABCG8 Regulates Vitamin D Absorption Rate and Contributes to its Efflux from the Intestine., [RefSeq, PubMed]; The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily, and functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. Disruption of this gene in mice results in thrombocytopenia, prolonged bleeding times, anemia, leukopenia, infertility, shortened life span and cardiomyopathy. Mice lacking this gene show symptoms of sitosterolemia. [provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q540E8", "ec_number_list": "7.6.2.1;7.6.2.-;7.6.2.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043235 receptor complex;GO:0045177 apical part of cell;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007584 response to nutrient;GO:0055085 transmembrane transport;GO:0010949 negative regulation of intestinal phytosterol absorption;GO:0030299 intestinal cholesterol absorption;GO:0033344 cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q99PE8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KML4-1", "uniprot_id": "ABRAL_MOUSE", "mass": 9030.0, "length": 81, "protein_name": "Costars family protein ABRACL", "gene_name": "Abracl", "organism": "Mouse", "refseq_name": "costars family protein ABRACL", "refseq_ac": "NP_082716", "gene_names_uniprotkb": "Abracl; 3110003A17Rik", "gene_names_refseq": "1700028I04Rik; 3110003A17Rik; Abracl", "protein_names_uniprotkb": "Costars family protein ABRACL; ABRA C-terminal-like protein", "protein_names_refseq": "ABRA C-terminal-like protein; costars family protein ABRACL", "tax_id": 10090, "disease": "", "pathway": " (mmu:73112)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;26495903;37759737", "class_list": "", "function": "Associates with the actin cytoskeleton and may modulate actin dynamics, in favor of increasing the relative content of F-actin, therefore may play a role in cell migration. May be acting by inhibiting CFL1-mediated actin depolymerization., [UniProtKB, UniProtKB]; Characterization of the Abracl-Expressing Cell Populations in the Embryonic Mammalian Telencephalon. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHQ7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0032970 regulation of actin filament-based process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4KML4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ60-1", "uniprot_id": "6PGL_MOUSE", "mass": 27254.0, "length": 257, "protein_name": "6-phosphogluconolactonase", "gene_name": "Pgls", "organism": "Mouse", "refseq_name": "6-phosphogluconolactonase isoform 2", "refseq_ac": "NP_001281198", "gene_names_uniprotkb": "Pgls", "gene_names_refseq": "1110030K05Rik; Pgls; Plgs", "protein_names_uniprotkb": "6-phosphogluconolactonase; 3.1.1.31; 6PGL", "protein_names_refseq": "6-phosphogluconolactonase isoform 2; 6PGL", "tax_id": 10090, "disease": "", "pathway": " (mmu:66171); (R-MMU-71336)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21183079;21750661;31219806;31779658;33300544;34428180;39627609", "class_list": "", "function": "Hub gene underlying brain aging Erratum:[Genome Biol. 2020 Feb 24;21(1):46. doi: 10.1186/s13059-020-01962-z. PMID: 32093779] Publication Status: Online-Only, [RefSeq, PubMed]; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TA62", "ec_number_list": "3.1.1.31;1.1.1.47;1.1.1.363", "go_molecular_function": "GO:0017057 6-phosphogluconolactonase activity;GO:0048029 monosaccharide binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006098 pentose-phosphate shunt;GO:0009051 pentose-phosphate shunt, oxidative branch", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CQ60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q925E7-1", "uniprot_id": "2ABD_MOUSE", "mass": 51957.0, "length": 453, "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform", "gene_name": "Ppp2r2d", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform 1", "refseq_ac": "NP_080667", "gene_names_uniprotkb": "Ppp2r2d; D7Ertd753e; Kiaa1541", "gene_names_refseq": "1300017E19Rik; D7Ertd753e; MDS026; Ppp2r2d", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; PP2A subunit B isoform B55-delta; PP2A subunit B isoform PR55-delta; PP2A subunit B isoform R2-delta; PP2A subunit B isoform delta", "protein_names_refseq": "serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform 1", "tax_id": 10090, "disease": "autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441)", "pathway": " (mmu:52432)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;24476824;32897879;33300544;35831019;36241614;39003739", "class_list": "", "function": "In tumours, Ppp2r2d knockdown inhibited T-cell apoptosis and enhanced T-cell proliferation as well as cytokine production, [RefSeq, PubMed]; Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D. Publication Status: Online-Only, [RefSeq, PubMed]; PPP2R2D Suppresses Effector T Cell Exhaustion and Regulatory T Cell Expansion and Inhibits Tumor Growth in Melanoma., [RefSeq, PubMed]; PPP2R2D suppresses IL-2 production and Treg function. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:39003739). Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (PubMed:39003739). The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPN5", "ec_number_list": "", "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0010458 exit from mitosis;GO:0051983 regulation of chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q925E7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q811Q4-1", "uniprot_id": "ADA29_MOUSE", "mass": 86445.0, "length": 763, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 29", "gene_name": "Adam29", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Adam29", "gene_names_refseq": "", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 29; ADAM 29", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:244486)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15028286;21750661;25428506", "class_list": "", "function": "May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein (By similarity)., [UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 8, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:1990913 sperm head plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0003016 respiratory system process;GO:0006508 proteolysis;GO:0097009 energy homeostasis;GO:0008584 male gonad development;GO:0042060 wound healing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q811Q4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63805-1", "uniprot_id": "A1AG3_MOUSE", "mass": 24069.0, "length": 206, "protein_name": "Alpha-1-acid glycoprotein 3", "gene_name": "Orm3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Orm3; Agp-3; Orm-3", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-1-acid glycoprotein 3; AGP 3; OMD 3; Orosomucoid-3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-114608); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1605854;21750661", "class_list": "", "function": "Functions as a transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Appears to function in modulating the activity of the immune system during the acute-phase reaction., [UniProtKB, UniProtKB, UniProtKB]; Functions as transport protein in the blood stream., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0036094 small molecule binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006953 acute-phase response;GO:0002682 regulation of immune system process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63805-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35945-1", "uniprot_id": "AL1A7_MOUSE", "mass": 54588.0, "length": 501, "protein_name": "Aldehyde dehydrogenase, cytosolic 1", "gene_name": "Aldh1a7", "organism": "Mouse", "refseq_name": "aldehyde dehydrogenase, cytosolic 1", "refseq_ac": "NP_036051", "gene_names_uniprotkb": "Aldh1a7; Aldh-pb", "gene_names_refseq": "Ahd2-like; Aldh-pb; Aldh1a4; Aldh1a7; Aldhpb", "protein_names_uniprotkb": "Aldehyde dehydrogenase, cytosolic 1; 1.2.1.3; ALDH class 1; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A7; Aldehyde dehydrogenase phenobarbital-inducible", "protein_names_refseq": "ALDH class 1; ALDH-E1; ALHDII; Aldehyde dehydrogenase 1 (phenobarbitol inducible); aldehyde dehydrogenase family 1 member A7; aldehyde dehydrogenase family 1, subfamily A4; aldehyde dehydrogenase phenobarbital-inducible; aldehyde dehydrogenase, cytosolic 1", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); pancreatic cancer (Disease Ontology:DOID:1793); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:26358)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10191271;25428506;34428180;37453647;37507081", "class_list": "", "function": "Can oxidize benzaldehyde, propionaldehyde and acetaldehyde (By similarity). No detectable activity with retinal., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZX7", "ec_number_list": "1.2.1.3;1.2.1.48;1.2.1.36;1.2.1.19;1.2.1.28;1.2.1.5;1.2.1.94;1.2.1.7;1.7.1.-;1.2.1.31;1.2.1.8;1.2.1.47;1.2.1.46", "go_molecular_function": "GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0018479 benzaldehyde dehydrogenase (NAD+) activity;GO:0106373 3-deoxyglucosone dehydrogenase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006068 ethanol catabolic process;GO:0006081 aldehyde metabolic process;GO:0030392 fructosamine catabolic process;GO:0006001 fructose catabolic process;GO:0110095 cellular detoxification of aldehyde", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35945-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04756-1", "uniprot_id": "ACHA_MOUSE", "mass": 51939.0, "length": 457, "protein_name": "Acetylcholine receptor subunit alpha", "gene_name": "Chrna1", "organism": "Mouse", "refseq_name": "acetylcholine receptor subunit alpha precursor", "refseq_ac": "NP_031415", "gene_names_uniprotkb": "Chrna1; Acra", "gene_names_refseq": "Achr-1; Acra; Chrna1", "protein_names_uniprotkb": "Acetylcholine receptor subunit alpha", "protein_names_refseq": "acetylcholine receptor subunit alpha precursor; acetylcholine receptor subunit alpha; cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)", "tax_id": 10090, "disease": "congenital myasthenic syndrome 1B (Disease Ontology:DOID:0110662); congenital myasthenic syndrome 1A (Disease Ontology:DOID:0110663); alcohol use disorder (Disease Ontology:DOID:1574); congenital myasthenic syndrome (Disease Ontology:DOID:3635)", "pathway": " (mmu:11435); (R-MMU-629594); (R-MMU-629597)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "17643119;2993547;3755237", "class_list": "", "function": "This gene encodes an alpha subunit of the muscle-derived nicotinic acetylcholine receptor, a pentameric neurotransmitter receptor and member of the ligand-gated ion channel superfamily. The alpha subunit plays a role in substrate binding and channel gating. [provided by RefSeq, Nov 2012]., [RefSeq]; Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0009986 cell surface;GO:0016020 membrane;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0007528 neuromuscular junction development;GO:0019228 neuronal action potential", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P04756-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09690-1", "uniprot_id": "ACHB_MOUSE", "mass": 56931.0, "length": 501, "protein_name": "Acetylcholine receptor subunit beta", "gene_name": "Chrnb1", "organism": "Mouse", "refseq_name": "acetylcholine receptor subunit beta isoform 1 precursor", "refseq_ac": "NP_033731", "gene_names_uniprotkb": "Chrnb1; Acrb", "gene_names_refseq": "Achr-2; Acrb; Chrnb1", "protein_names_uniprotkb": "Acetylcholine receptor subunit beta", "protein_names_refseq": "AChR beta; acetylcholine receptor beta; acetylcholine receptor subunit beta isoform 1 precursor; acetylcholine receptor subunit beta; cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)", "tax_id": 10090, "disease": "congenital myasthenic syndrome 2C (Disease Ontology:DOID:0110680); congenital myasthenic syndrome 2A (Disease Ontology:DOID:0110681)", "pathway": " (mmu:11443)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "24860174;25428506;2708381;31219806;31261376;3782129", "class_list": "", "function": "After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB]; Loss of mitochondrial protein CHCHD10 in skeletal muscle causes neuromuscular junction impairment., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5F292", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0042166 acetylcholine binding;GO:0015267 channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0031594 neuromuscular junction;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0006936 muscle contraction;GO:0007165 signal transduction;GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P09690-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20782-1", "uniprot_id": "ACHE_MOUSE", "mass": 54914.0, "length": 493, "protein_name": "Acetylcholine receptor subunit epsilon", "gene_name": "Chrne", "organism": "Mouse", "refseq_name": "acetylcholine receptor subunit epsilon precursor", "refseq_ac": "NP_033733", "gene_names_uniprotkb": "Chrne; Acre", "gene_names_refseq": "AChrepsilon; Acre; Chrne; nAChRE", "protein_names_uniprotkb": "Acetylcholine receptor subunit epsilon", "protein_names_refseq": "AchR epsilon subunit; acetylcholine receptor subunit epsilon precursor; acetylcholine receptor subunit epsilon; nicotinic acetylcholine receptor epsilon subunit", "tax_id": 10090, "disease": "congenital myasthenic syndrome 4B (Disease Ontology:DOID:0110677); congenital myasthenic syndrome 4A (Disease Ontology:DOID:0110678); congenital myasthenic syndrome 4C (Disease Ontology:DOID:0110679)", "pathway": " (mmu:11448); (R-MMU-629587)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;2251144;2708381", "class_list": "", "function": "After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes the epsilon subunit of the muscle-derived nicotinic acetylcholine receptor, a pentameric neurotransmitter receptor and member of the ligand-gated ion channel superfamily. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. In mice, deficiency of this gene can lead to a decline in the number of nicotinic acetylcholine receptors at neuromuscular junctions and causes progressive muscle weakness, atrophy and premature death. Mutations in this gene serve as a pathophysiological model for human congenital myasthenia. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Nov 2012]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity;GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0031594 neuromuscular junction;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0007271 synaptic transmission, cholinergic;GO:0042391 regulation of membrane potential;GO:0095500 acetylcholine receptor signaling pathway;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P20782-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21836-1", "uniprot_id": "ACES_MOUSE", "mass": 68169.0, "length": 614, "protein_name": "Acetylcholinesterase", "gene_name": "Ache", "organism": "Mouse", "refseq_name": "acetylcholinesterase precursor", "refseq_ac": "NP_001276939", "gene_names_uniprotkb": "Ache", "gene_names_refseq": "Ache", "protein_names_uniprotkb": "Acetylcholinesterase; 3.1.1.7; AChE", "protein_names_refseq": "acetylcholinesterase precursor", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); Hirschsprung's disease (Disease Ontology:DOID:10487); Alzheimer's disease (Disease Ontology:DOID:10652); Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); epilepsy (Disease Ontology:DOID:1826); cannabis dependence (Disease Ontology:DOID:1849); leptospirosis (Disease Ontology:DOID:2297); multiple sclerosis (Disease Ontology:DOID:2377); myasthenia gravis (Disease Ontology:DOID:437); acute stress disorder (Disease Ontology:DOID:6088); subacute delirium (Disease Ontology:DOID:8645); bacterial meningitis (Disease Ontology:DOID:9470); type 1 diabetes mellitus (Disease Ontology:DOID:9744); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:11423)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11239002;11804574;12505979;21750661;2400605;30899004;33300544;8521480;9915834", "class_list": "glycogene", "function": "Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 16, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.-;3.1.1.7", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0042166 acetylcholine binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005518 collagen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005635 nuclear envelope;GO:0005788 endoplasmic reticulum lumen;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0019695 choline metabolic process;GO:0007155 cell adhesion;GO:0031623 receptor internalization;GO:0095500 acetylcholine receptor signaling pathway;GO:0001919 regulation of receptor recycling", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P21836-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35363-1", "uniprot_id": "5HT2A_MOUSE", "mass": 52842.0, "length": 471, "protein_name": "5-hydroxytryptamine receptor 2A", "gene_name": "Htr2a", "organism": "Mouse", "refseq_name": "5-hydroxytryptamine receptor 2A", "refseq_ac": "NP_766400", "gene_names_uniprotkb": "Htr2a; Htr2", "gene_names_refseq": "5-HT-2A; 5-HT-2; E030013E04; Htr-2; Htr2a; Htr2", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 2A; 5-HT-2A; 5-HT-2; Serotonin receptor 2A", "protein_names_refseq": "5-HT2A receptor; 5-hydroxytryptamine 2 receptor; 5-hydroxytryptamine receptor 2A", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); obsessive-compulsive disorder (Disease Ontology:DOID:10933); pathological gambling (Disease Ontology:DOID:12399); bladder neck obstruction (Disease Ontology:DOID:13948); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); alcoholic psychosis (Disease Ontology:DOID:252); inflammatory and toxic neuropathy (Disease Ontology:DOID:2537); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); hyperglycemia (Disease Ontology:DOID:4195); pancreatitis (Disease Ontology:DOID:4989); schizophrenia (Disease Ontology:DOID:5419); congestive heart failure (Disease Ontology:DOID:6000); acute stress disorder (Disease Ontology:DOID:6088); cocaine abuse (Disease Ontology:DOID:809); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:15558); (R-MMU-390666); (R-MMU-416476)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11960784;1333538;14988405;16873667;17270739;18297054;21645528;23129762;23346101;38145872;38509093", "class_list": "", "function": "CX3CR1 mediates motor dysfunction in mice through 5-HTR2a., [RefSeq, PubMed]; G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:11960784, PubMed:16873667, PubMed:17270739, PubMed:18297054, PubMed:21645528, PubMed:23129762, PubMed:23346101). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). HTR2A is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (By similarity). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:18297054). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances (PubMed:16873667, PubMed:17270739, PubMed:18297054, PubMed:23129762). Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (PubMed:11960784, PubMed:23346101)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 26, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0001659 temperature homeostasis;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007613 memory;GO:0008284 positive regulation of cell population proliferation;GO:0045600 positive regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P35363-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49582-1", "uniprot_id": "ACHA7_MOUSE", "mass": 56632.0, "length": 502, "protein_name": "Neuronal acetylcholine receptor subunit alpha-7", "gene_name": "Chrna7", "organism": "Mouse", "refseq_name": "neuronal acetylcholine receptor subunit alpha-7 precursor", "refseq_ac": "NP_031416", "gene_names_uniprotkb": "Chrna7; Acra7", "gene_names_refseq": "Acra7; Chrna7; alpha7; nAChR7; nAchR", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-7; Nicotinic acetylcholine receptor subunit alpha-7; nAChR7", "protein_names_refseq": "acetylcholine receptor alpha 7 neural; alpha7 nicotinic receptor; alpha7-nAChR; neuronal acetylcholine receptor subunit alpha-7 precursor; neuronal acetylcholine receptor subunit alpha-7; nicotinic acetylcholine receptor subunit alpha-7", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); Alzheimer's disease (Disease Ontology:DOID:10652); Lewy body dementia (Disease Ontology:DOID:12217); lung cancer (Disease Ontology:DOID:1324); cognitive disorder (Disease Ontology:DOID:1561); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); schizophrenia (Disease Ontology:DOID:5419); rheumatoid arthritis (Disease Ontology:DOID:7148); malignant pleural mesothelioma (Disease Ontology:DOID:7474); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (mmu:11441); (R-MMU-629594)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12508119;15502843;16025117;21083424;24298024;25259522;32783947;33239400;7601470", "class_list": "", "function": "Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA7 forms homopentameric neuronal acetylcholine receptors abundantly expressed in the central nervous system, characterized by fast desensitization and high calcium permeability. Also forms heteropentamers with CHRNB2, mainly expressed in basal forebrain cholinergic neurons. Involved in the modulation of calcium-dependent signaling pathways and influences the release of neurotransmitters, including dopamine, glutamate and GABA. Involved in the modulation of calcium-dependent signaling pathways and influences the release of neurotransmitters, including dopamine, glutamate and GABA (PubMed:33239400). Also expressed in non-neuronal cells such as immune cells like lymphocytes, monocytes and macrophages (PubMed:12508119). In T cells, activation induces metabotropic signaling that results in an increase of intracellular Ca2+ concentrations, independent of ionotropic receptor functions (By similarity). In macrophages, required for acetylcholine-mediated inhibition of TNF and other inflammatory cytokine release. Once activated by acetylcholine, nicotine or other agonists, selectively inhibits production of pro-inflammatory cytokines while leaving anti-inflammatory cytokines undisturbed (PubMed:12508119, PubMed:21083424, PubMed:24298024, PubMed:25259522). Stimulates the cholinergic anti-inflammatory pathway, controlling inflammation by inhibiting NFKB nuclear translocation and activating the JAK2-STAT3 pathway, independently of ion channel activity (PubMed:15502843, PubMed:16025117, PubMed:25259522). Also expressed in the urothelium where it modulates reflex bladder activity by increasing intracellular calcium through internal stores and decreasing basal ATP release (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-;2.7.11.1", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005216 monoatomic ion channel activity;GO:0015464 acetylcholine receptor activity;GO:0015643 toxic substance binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0006897 endocytosis;GO:0007271 synaptic transmission, cholinergic;GO:0007611 learning or memory;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P49582-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56375-1", "uniprot_id": "ACYP2_MOUSE", "mass": 11878.0, "length": 106, "protein_name": "Acylphosphatase-2", "gene_name": "Acyp2", "organism": "Mouse", "refseq_name": "acylphosphatase-2", "refseq_ac": "NP_083620", "gene_names_uniprotkb": "Acyp2; Acyp", "gene_names_refseq": "2310004B09Rik; Acyp2", "protein_names_uniprotkb": "Acylphosphatase-2; 3.6.1.7; Acylphosphatase, muscle type isozyme; Acylphosphate phosphohydrolase 2", "protein_names_refseq": "acylphosphatase, muscle type isozyme; acylphosphatase-2; acylphosphate phosphohydrolase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:75572)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "30059200;36288343;37507081;39927985", "class_list": "", "function": "catalyzes the hydrolysis of acylphosphates compounds containing a carboxylphosphate bond., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5SPV7;Q8BQX2", "ec_number_list": "3.6.1.7", "go_molecular_function": "GO:0042802 identical protein binding;GO:0003998 acylphosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P56375-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00898-1", "uniprot_id": "A1AT5_MOUSE", "mass": 45891.0, "length": 413, "protein_name": "Alpha-1-antitrypsin 1-5", "gene_name": "Serpina1e", "organism": "Mouse", "refseq_name": "alpha-1-antitrypsin 1-5 precursor", "refseq_ac": "NP_033273", "gene_names_uniprotkb": "Serpina1e; Dom5; Spi1-5", "gene_names_refseq": "Dom5; PI5; Serpina1e; Spi1-5", "protein_names_uniprotkb": "Alpha-1-antitrypsin 1-5; Alpha-1 protease inhibitor 5; Serine protease inhibitor 1-5; Serine protease inhibitor A1e; Serpin A1e", "protein_names_refseq": "alpha-1 protease inhibitor 5; alpha-1-antitrypsin 1-5 precursor; alpha-1-antitrypsin 1-5; serine (or cysteine) proteinase inhibitor, clade A, member 1e; serine protease inhibitor 1-5; serine protease inhibitor A1e; serpin A1e", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); chemical colitis (Disease Ontology:DOID:0060186); ileitis (Disease Ontology:DOID:0060189); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); pancreatic cancer (Disease Ontology:DOID:1793); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); acute pancreatitis (Disease Ontology:DOID:2913); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); liver disease (Disease Ontology:DOID:409); primary hyperaldosteronism (Disease Ontology:DOID:446); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); proteinuria (Disease Ontology:DOID:576); pulmonary hypertension (Disease Ontology:DOID:6432); osteoarthritis (Disease Ontology:DOID:8398); colorectal cancer (Disease Ontology:DOID:9256); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:20704)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12659817;16944957;19423638;1946354;30084848;31219806;34428180;37507081;8619829", "class_list": "", "function": "Clathrin-mediated endocytosis regulates A1AT intracellular function in the lung endothelium and may be an important determinant of the serpin's protection against developing cigarette smoke-induced emphysema, [RefSeq, PubMed]; Does not inhibit elastase or chymotrypsin. No target protease has been identified to date., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 23, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJ83;Q545P1", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0042802 identical protein binding;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0010288 response to lead ion;GO:0034097 response to cytokine;GO:0043434 response to peptide hormone;GO:1900004 negative regulation of serine-type endopeptidase activity;GO:0033986 response to methanol", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q00898-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02284-1", "uniprot_id": "5HT1F_MOUSE", "mass": 41977.0, "length": 366, "protein_name": "5-hydroxytryptamine receptor 1F", "gene_name": "Htr1f", "organism": "Mouse", "refseq_name": "5-hydroxytryptamine receptor 1F", "refseq_ac": "NP_032336", "gene_names_uniprotkb": "Htr1f; 5ht1f; Htr1eb", "gene_names_refseq": "Htr1eb; Htr1f", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 1F; 5-HT-1E-beta; 5-HT-1F; 5-HT1F; Serotonin receptor 1F", "protein_names_refseq": "5-HT-1E-beta; 5-HT-1F; 5-HT1F; 5-hydroxytryptamine (serotonin) receptor 1E beta; 5-hydroxytryptamine receptor 1F; serotonin receptor 1F", "tax_id": 10090, "disease": "", "pathway": " (mmu:15557); (R-MMU-390666); (R-MMU-418594)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "1328180", "class_list": "", "function": "G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1328180). Also functions as a receptor for various alkaloids and psychoactive substances (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). HTR1F is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0001586 Gi/o-coupled serotonin receptor activity;GO:0099589 serotonin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q02284-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14DN9-1", "uniprot_id": "AKD1B_MOUSE", "mass": 58456.0, "length": 521, "protein_name": "Ankyrin repeat and death domain-containing protein 1B", "gene_name": "Ankdd1b", "organism": "Mouse", "refseq_name": "ankyrin repeat and death domain-containing protein 1B isoform 2", "refseq_ac": "NP_001036179", "gene_names_uniprotkb": "Ankdd1b", "gene_names_refseq": "9330128J19Rik; Ankdd1b", "protein_names_uniprotkb": "Ankyrin repeat and death domain-containing protein 1B", "protein_names_refseq": "ankyrin repeat and death domain-containing protein 1B isoform 2; ankyrin repeat and death domain-containing protein 1B; ankyrin repeat and death domain-containing protein ENSP00000345065 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:271144)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZP7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q14DN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q19LI2-1", "uniprot_id": "A1BG_MOUSE", "mass": 56554.0, "length": 512, "protein_name": "Alpha-1B-glycoprotein", "gene_name": "A1bg", "organism": "Mouse", "refseq_name": "alpha-1B-glycoprotein precursor", "refseq_ac": "NP_001074536", "gene_names_uniprotkb": "A1bg", "gene_names_refseq": "A1bg; C44", "protein_names_uniprotkb": "Alpha-1B-glycoprotein; Alpha-1-B glycoprotein", "protein_names_refseq": "alpha-1B-glycoprotein precursor; alpha-1B-glycoprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:117586); (R-MMU-114608); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16723264;17330941;21750661;26495903;28011936;30084848;35984892;37507081", "class_list": "", "function": "Expression of P5 protein cDNA #5 is liver-specific, sexually dimorphic, age-dependent, and may be involved in hepatocyte hyperplasia and liver enlargement., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0060396 growth hormone receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q19LI2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2XU92-1", "uniprot_id": "ACBG2_MOUSE", "mass": 74319.0, "length": 667, "protein_name": "Long-chain-fatty-acid--CoA ligase ACSBG2", "gene_name": "Acsbg2", "organism": "Mouse", "refseq_name": "long-chain-fatty-acid--CoA ligase ACSBG2", "refseq_ac": "NP_001034203", "gene_names_uniprotkb": "Acsbg2; Bgr", "gene_names_refseq": "Acsbg2; Bgr", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase ACSBG2; 6.2.1.15; 6.2.1.3; Acyl-CoA synthetase bubblegum family member 2; Arachidonate--CoA ligase ACSBG2; Bubblegum-related protein", "protein_names_refseq": "arachidonate--CoA ligase ACSBG2; bubblegum-related protein; long-chain-fatty-acid--CoA ligase ACSBG2", "tax_id": 10090, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588)", "pathway": " (mmu:328845); (R-MMU-75876)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16371355;16762313", "class_list": "", "function": "Catalyzes the conversion of fatty acids such as long chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis., [UniProtKB, UniProtKB]; The limited tissue expression pattern and limited substrate specificity rule out a likely role for this enzyme in X-linked adrenoleukodystrophy pathology., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.2.1.3;6.2.1.-;6.2.1.15;6.2.1.7;6.2.1.24;6.2.1.76;6.2.1.2;6.2.1.25", "go_molecular_function": "GO:0005524 ATP binding;GO:0047617 fatty acyl-CoA hydrolase activity;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0047676 arachidonate-CoA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0042759 long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2XU92-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q497M3-1", "uniprot_id": "ABEC4_MOUSE", "mass": 42721.0, "length": 374, "protein_name": "Putative deaminase APOBEC-4", "gene_name": "Apobec4", "organism": "Mouse", "refseq_name": "putative deaminase APOBEC-4", "refseq_ac": "NP_001074666", "gene_names_uniprotkb": "Apobec4", "gene_names_refseq": "4933431M11Rik; Apobec4", "protein_names_uniprotkb": "Putative deaminase APOBEC-4; 3.5.4.-; Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4", "protein_names_refseq": "apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative); putative C->U-editing enzyme APOBEC-4; putative deaminase APOBEC-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:71281); (R-MMU-72200); (R-MMU-75094)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16082223", "class_list": "", "function": "APOBEC4 is expressed primarily in testis which suggests the possibility that it is an editing enzyme for mRNAs involved in spermatogenesis, [RefSeq, PubMed]; Putative deaminase whose physiological substrate is not yet known., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.4.-;3.5.4.36;3.5.4.38", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q497M3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61224-1", "uniprot_id": "5HT1D_MOUSE", "mass": 41594.0, "length": 374, "protein_name": "5-hydroxytryptamine receptor 1D", "gene_name": "Htr1d", "organism": "Mouse", "refseq_name": "5-hydroxytryptamine receptor 1D", "refseq_ac": "NP_001272411", "gene_names_uniprotkb": "Htr1d; Gpcr14", "gene_names_refseq": "5-HT-1D; 5-HT1D; Gpcr14; Htr1db; Htr1d", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 1D; 5-HT-1D; 5-HT1D; Serotonin receptor 1D", "protein_names_refseq": "5-hydroxytryptamine (serotonin) receptor 1D beta; 5-hydroxytryptamine receptor 1D; G-protein coupled receptor 14; serotonin receptor 1D", "tax_id": 10090, "disease": "", "pathway": " (mmu:15552); (R-MMU-390666); (R-MMU-418594)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "22273508;8288218;8978753", "class_list": "", "function": "G protein-coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZB48;Q61615;Q8BUW7", "ec_number_list": "", "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0001586 Gi/o-coupled serotonin receptor activity;GO:0099589 serotonin receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098992 neuronal dense core vesicle;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0040012 regulation of locomotion;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q61224-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61285-1", "uniprot_id": "ABCD2_MOUSE", "mass": 83457.0, "length": 741, "protein_name": "ATP-binding cassette sub-family D member 2", "gene_name": "Abcd2", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family D member 2 isoform 1", "refseq_ac": "NP_036124", "gene_names_uniprotkb": "Abcd2; Aldr", "gene_names_refseq": "ABC39; ALDL1; ALDRP; ALDR; Abcd2", "protein_names_uniprotkb": "ATP-binding cassette sub-family D member 2; 3.1.2.-; 7.6.2.-; Adrenoleukodystrophy-related protein", "protein_names_refseq": "ATP-binding cassette sub-family D member 2 isoform 1; ATP-binding cassette, sub-family D (ALD), member 2; adrenoleukodystrophy related; adrenoleukodystrophy-related protein", "tax_id": 10090, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588)", "pathway": " (mmu:26874); (R-MMU-1369062); (R-MMU-9603798)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "16223892;17208939;18854420;30769094;36207570;37453647;8577752", "class_list": "", "function": "ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (By similarity). Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transported in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (By similarity). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro) (By similarity). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:16223892, PubMed:18854420)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Combined absence of ABCD1 and ABCD2 proteins resulted in the accumulation of very long-chain fatty acids in murine BV-2 cells., [RefSeq, PubMed]; Targeted Brain Delivery of Dendrimer-4-Phenylbutyrate Ameliorates Neurological Deficits in a Long-Term ABCD1-Deficient Mouse Model of X-Linked Adrenoleukodystrophy., [RefSeq, PubMed]; The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of Abcd1 and/or other peroxisomal ABC transporters. Mutations in the human gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J0U5;Q8BQ63;Q8C4B6", "ec_number_list": "1.2.1.3;1.2.1.94;3.1.2.-;7.6.2.-;2.3.2.27;2.3.2.36;7.4.2.-", "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0000038 very long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0032000 positive regulation of fatty acid beta-oxidation;GO:0042760 very long-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q61285-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61694-1", "uniprot_id": "3BHS5_MOUSE", "mass": 41892.0, "length": 373, "protein_name": "NADPH-dependent 3-keto-steroid reductase Hsd3b5", "gene_name": "Hsd3b5", "organism": "Mouse", "refseq_name": "NADPH-dependent 3-keto-steroid reductase Hsd3b5", "refseq_ac": "NP_032321", "gene_names_uniprotkb": "Hsd3b5", "gene_names_refseq": "Hsd3b5", "protein_names_uniprotkb": "NADPH-dependent 3-keto-steroid reductase Hsd3b5; 1.1.1.210; 1.1.1.270; 3 beta-HSD V; 3 beta-hydroxysteroid dehydrogenase type 5; 3 beta-hydroxysteroid dehydrogenase type V; Dihydrotestosterone 3-ketoreductase", "protein_names_refseq": "3 beta-hydroxysteroid dehydrogenase type 5; 3 beta-hydroxysteroid dehydrogenase type V; 3(beta)HSDV; 3-beta-HSD V; 3-beta-hydroxy-5-ene steroid dehydrogenase; NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; NADPH-dependent 3-keto-steroid reductase Hsd3b5; dihydrotestosterone 3-ketoreductase; hydroxysteroid dehydrogenase-5, delta<5>-3-beta; progesterone reductase", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hypospadias (Disease Ontology:DOID:10892); polycystic ovary syndrome (Disease Ontology:DOID:11612)", "pathway": " (mmu:15496); (R-MMU-193048); (R-MMU-193993); (R-MMU-194002)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "23576753;34428180;35820727;7491113", "class_list": "", "function": "Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Does not function as an isomerase., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91X27", "ec_number_list": "1.1.1.-;1.1.1.145;5.3.3.1;1.1.1.270;1.1.1.62;1.1.1.210", "go_molecular_function": "GO:0003854 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity;GO:0004769 steroid Delta-isomerase activity;GO:0005496 steroid binding;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0000253 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0006694 steroid biosynthetic process;GO:0008207 C21-steroid hormone metabolic process;GO:0035634 response to stilbenoid", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q61694-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61767-1", "uniprot_id": "3BHS4_MOUSE", "mass": 41766.0, "length": 373, "protein_name": "NADPH-dependent 3-keto-steroid reductase Hsd3b4", "gene_name": "Hsd3b4", "organism": "Mouse", "refseq_name": "NADPH-dependent 3-keto-steroid reductase Hsd3b4", "refseq_ac": "NP_001104806", "gene_names_uniprotkb": "Hsd3b4", "gene_names_refseq": "Hsd3b4", "protein_names_uniprotkb": "NADPH-dependent 3-keto-steroid reductase Hsd3b4; 1.1.1.210; 1.1.1.270; 3 beta-HSD IV; 3 beta-hydroxysteroid dehydrogenase type 4; 3 beta-hydroxysteroid dehydrogenase type IV; Dihydrotestosterone 3-ketoreductase", "protein_names_refseq": "3 beta-hydroxysteroid dehydrogenase 4; 3 beta-hydroxysteroid dehydrogenase type 4; 3 beta-hydroxysteroid dehydrogenase type IV; 3-beta-HSD IV; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase; NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; NADPH-dependent 3-keto-steroid reductase Hsd3b4; dihydrotestosterone 3-ketoreductase; hydroxysteroid dehydrogenase-4, delta<5>-3-beta; progesterone reductase", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hypospadias (Disease Ontology:DOID:10892); polycystic ovary syndrome (Disease Ontology:DOID:11612)", "pathway": " (mmu:100043456); (mmu:15495); (R-MMU-193048); (R-MMU-193993); (R-MMU-194002)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "19172483;22217834;30084848;34428180;8145763", "class_list": "", "function": "Data suggest that newly synthesized protein(s) are required for cAMP induction of Hsd3b4 and CYP17 mRNA levels (but not of CYP11A mRNA levels). [REVIEW] Review article, [RefSeq, PubMed]; Present in the lymphoid organs after immunization with soluble antigen, [RefSeq, PubMed]; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Does not function as an isomerase., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.-;1.1.1.145;5.3.3.1;1.1.1.270;1.1.1.62;1.1.1.210", "go_molecular_function": "GO:0003854 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity;GO:0004769 steroid Delta-isomerase activity;GO:0005496 steroid binding;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0000253 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0006694 steroid biosynthetic process;GO:0008207 C21-steroid hormone metabolic process;GO:0035634 response to stilbenoid", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61767-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64343-1", "uniprot_id": "ABCG1_MOUSE", "mass": 74033.0, "length": 666, "protein_name": "ATP-binding cassette sub-family G member 1", "gene_name": "Abcg1", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family G member 1", "refseq_ac": "NP_033723", "gene_names_uniprotkb": "Abcg1; Abc8; Wht1", "gene_names_refseq": "Abc8; Abcg1; White", "protein_names_uniprotkb": "ATP-binding cassette sub-family G member 1; 7.6.2.-; ATP-binding cassette transporter 8; White protein homolog", "protein_names_refseq": "ATP-binding cassette 8; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; ATP-binding cassette, sub-family G (WHITE), member 1; white protein homolog", "tax_id": 10090, "disease": "end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:11307); (R-MMU-1369062); (R-MMU-8964058)", "pathway_count": 3, "publication_count": 26, "publication_id_list": "10799558;11162488;12777468;14668945;18250455;18299400;19224205;19892989;20173027;21540332;21750661;21952136;22645316;23388354;25605945;26495903;26740625;27802388;28011936;28315936;34428180;35820727;35984892;37828378;8703120;9034316", "class_list": "", "function": "Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP (PubMed:14668945). The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (By similarity)., [UniProtKB, UniProtKB, PubMed]; The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The human protein is involved in macrophage cholesterol efflux and may regulate cellular lipid homeostasis in other cell types. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.1;7.6.2.2;7.6.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0016887 ATP hydrolysis activity;GO:0043531 ADP binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0010888 negative regulation of lipid storage;GO:0008203 cholesterol metabolic process;GO:0010875 positive regulation of cholesterol efflux;GO:0033700 phospholipid efflux;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q64343-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PD28-1", "uniprot_id": "2A5B_MOUSE", "mass": 57342.0, "length": 497, "protein_name": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform", "gene_name": "Ppp2r5b", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform", "refseq_ac": "NP_937811", "gene_names_uniprotkb": "Ppp2r5b", "gene_names_refseq": "B'beta; Ppp2r5b", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; PP2A B subunit isoform B'-beta; PP2A B subunit isoform B56-beta; PP2A B subunit isoform PR61-beta; PP2A B subunit isoform R5-beta", "protein_names_refseq": "serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:225849); (R-MMU-141430); (R-MMU-141444); (R-MMU-195253); (R-MMU-196299); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-389356); (R-MMU-389513); (R-MMU-432142); (R-MMU-4641262); (R-MMU-5663220); (R-MMU-5673000); (R-MMU-5675221); (R-MMU-6811558); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 17, "publication_count": 4, "publication_id_list": "25428506;27521959;34428180;36210013", "class_list": "", "function": "As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation., [UniProtKB, UniProtKB]; PPP2R5B, a B subunit of PP2A is a negative regulator of Akt phosphorylation contributing partly to the chronic hyperinsulinemia induced insulin resistance in adipocytes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V3S8;Q8R342", "ec_number_list": "", "go_molecular_function": "GO:0072542 protein phosphatase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0007165 signal transduction;GO:0010976 positive regulation of neuron projection development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0010469 regulation of signaling receptor activity;GO:0031334 positive regulation of protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PD28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PE15-1", "uniprot_id": "ABHDA_MOUSE", "mass": 33040.0, "length": 297, "protein_name": "Palmitoyl-protein thioesterase ABHD10, mitochondrial", "gene_name": "Abhd10", "organism": "Mouse", "refseq_name": "palmitoyl-protein thioesterase ABHD10, mitochondrial isoform 2 precursor", "refseq_ac": "NP_001258999", "gene_names_uniprotkb": "Abhd10", "gene_names_refseq": "Abhd10", "protein_names_uniprotkb": "Palmitoyl-protein thioesterase ABHD10, mitochondrial; 3.1.1.93; 3.1.2.22; Abhydrolase domain-containing protein 10; Acyl-protein thioesterase ABHD10; Alpha/beta hydrolase domain-containing protein 10; Mycophenolic acid acyl-glucuronide esterase, mitochondrial", "protein_names_refseq": "abhydrolase domain-containing protein 10, mitochondrial; acyl-protein thioesterase ABHD10; alpha/beta hydrolase domain-containing protein 10, mitochondrial; mycophenolic acid acyl-glucuronide esterase, mitochondrial; palmitoyl-protein thioesterase ABHD10, mitochondrial isoform 2 precursor; palmitoyl-protein thioesterase ABHD10, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:213012); (R-MMU-156588)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21078990;21750661;22294686;31740833;35978367;37400491", "class_list": "", "function": "Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins (PubMed:31740833). Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability (PubMed:31740833). Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate (By similarity)., [UniProtKB, UniProtKB, PubMed]; Identification of human ABHD10, which is responsible for AcMPAG deglucuronidation in the liver, [RefSeq, PubMed]; MiR-19b-3p regulated by BC002059/ABHD10 axis promotes cell apoptosis in myocardial infarction. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial localization of rat Abhd10, [RefSeq, PubMed]; The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a mitochondrially-localized enzyme that acts as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There are two pseudogenes for this gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMB4;Q8C3S8;Q8C724;Q8K188", "ec_number_list": "3.1.2.22;3.1.2.2;3.1.2.-;2.3.1.-;3.1.1.93;3.4.-.-;3.4.19.12", "go_molecular_function": "GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0102390 mycophenolic acid acyl-glucuronide esterase activity;GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0002084 protein depalmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6PE15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BM96-1", "uniprot_id": "AGRG7_MOUSE", "mass": 87684.0, "length": 785, "protein_name": "Adhesion G protein-coupled receptor G7", "gene_name": "Adgrg7", "organism": "Mouse", "refseq_name": "adhesion G-protein coupled receptor G7 precursor", "refseq_ac": "NP_766413", "gene_names_uniprotkb": "Adgrg7; Gpr128", "gene_names_refseq": "9130020O16Rik; Adgrg7; Gpr128", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor G7; G protein-coupled receptor 128", "protein_names_refseq": "G protein coupled receptor Gpr128; G protein-coupled receptor 128; adhesion G-protein coupled receptor G7 precursor; probable G-protein coupled receptor 128", "tax_id": 10090, "disease": "", "pathway": " (mmu:239853)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12679517;16393994;24574718;25428506;30604775;31599954", "class_list": "", "function": "Based on the crystal structures of ELMO2-RAE and its complex with BAI1 study identified aGPCR-GPR128 as another upstream receptor for the ELMO family scaffolds. Publication Status: Online-Only, [RefSeq, PubMed]; Generated a mouse model with a targeted deletion of Gpr128 and found reduced body weight and increased intestinal contraction frequency in this animal model., [RefSeq, PubMed]; Orphan receptor., [UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "A2RSY9;Q80T42", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BM96-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMN3-1", "uniprot_id": "ACHB3_MOUSE", "mass": 53112.0, "length": 464, "protein_name": "Neuronal acetylcholine receptor subunit beta-3", "gene_name": "Chrnb3", "organism": "Mouse", "refseq_name": "neuronal acetylcholine receptor subunit beta-3 isoform 2 precursor", "refseq_ac": "NP_081730", "gene_names_uniprotkb": "Chrnb3", "gene_names_refseq": "5730417K16Rik; Acrb3; Chrnb3", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit beta-3", "protein_names_refseq": "neuronal acetylcholine receptor subunit beta-3 isoform 2 precursor; neuronal acetylcholine receptor subunit beta-3", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); Parkinson's disease (Disease Ontology:DOID:14330); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); bipolar disorder (Disease Ontology:DOID:3312); congenital myasthenic syndrome (Disease Ontology:DOID:3635); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:108043); (R-MMU-629594); (R-MMU-629597)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;25428506;26318101;30084848;31145916;35820727", "class_list": "", "function": "Beta3 nicotinic subunits do not seem to influence nicotine reward but plays an important role in affective nicotine withdrawal signs., [RefSeq, PubMed]; Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. Has an accessory rather than functional role and is only able to form functional nAChRs when co-assembled with another beta subunit. Participates in pentameric assemblies along with CHRNA3, CHRNA4, CHRNA6, CHRNB2 and CHRNB4. Modulates receptor assembly and increases receptor sensitivity to nicotine when associated with CHRNB2, CHRNA4 and/or CHRNA6 as well as CHRNA3 and CHRNB4. Seems to play a role in nicotine addiction., [UniProtKB, UniProtKB]; Data provide evidence that the protective genetic variant at rs6474413 identified in human genetic studies reduces gene expression and that decreased beta3 gene expression in mice reduces nicotine intake, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8R5H3;Q9CYK8", "ec_number_list": "1.8.-.-;2.7.11.1", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0042166 acetylcholine binding;GO:1901363 heterocyclic compound binding", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0035094 response to nicotine;GO:0095500 acetylcholine receptor signaling pathway;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BMN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R0I0-1", "uniprot_id": "ACE2_MOUSE", "mass": 92368.0, "length": 805, "protein_name": "Angiotensin-converting enzyme 2", "gene_name": "Ace2", "organism": "Mouse", "refseq_name": "angiotensin-converting enzyme 2 precursor", "refseq_ac": "NP_001123985", "gene_names_uniprotkb": "Ace2", "gene_names_refseq": "2010305L05Rik; Ace2", "protein_names_uniprotkb": "Angiotensin-converting enzyme 2; 3.4.17.-; 3.4.17.23; ACE-related carboxypeptidase", "protein_names_refseq": "ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; angiotensin-converting enzyme 2 precursor", "tax_id": 10090, "disease": "thrombosis (Disease Ontology:DOID:0060903); COVID-19 (Disease Ontology:DOID:0080600); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); primary biliary cholangitis (Disease Ontology:DOID:12236); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); cerebral malaria (Disease Ontology:DOID:14069); glaucoma (Disease Ontology:DOID:1686); severe acute respiratory syndrome (Disease Ontology:DOID:2945); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); avian influenza (Disease Ontology:DOID:4492); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); lung disease (Disease Ontology:DOID:850); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:70008); (R-MMU-2022377)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;12075344;12487024;12967627;15452268;15949646;16001071;18424768;19185582;21750661;21913724;22677001;23535237;29570986;31599954", "class_list": "", "function": "ACE2 gene is expressed mainly in the kidney and the lungs., [RefSeq, PubMed]; Angiotensin-converting enzyme 2 is an essential regulator of heart function., [RefSeq, PubMed]; Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A (By similarity). By cleavage of angiotensin II, may be an important regulator of heart function (PubMed:12075344, PubMed:12967627). By cleavage of angiotensin II, may also have a protective role in acute lung injury (PubMed:16001071). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19, regulating its trafficking on the cell surface and its activity (PubMed:18424768, PubMed:19185582, PubMed:22677001)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Murine ACE2 less efficiently bound the S1 domain of SARS-CoV and supported less-efficient S protein-mediated infection., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 17, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q99N70;Q99N71", "ec_number_list": "3.4.17.23;3.4.17.-;3.4.-.-", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0008237 metallopeptidase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0004180 carboxypeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0046513 ceramide biosynthetic process;GO:0002003 angiotensin maturation;GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin;GO:0060135 maternal process involved in female pregnancy", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q8R0I0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4X1-1", "uniprot_id": "ACER1_MOUSE", "mass": 32082.0, "length": 273, "protein_name": "Alkaline ceramidase 1", "gene_name": "Acer1", "organism": "Mouse", "refseq_name": "alkaline ceramidase 1", "refseq_ac": "NP_783858", "gene_names_uniprotkb": "Acer1; Asah3", "gene_names_refseq": "2310024P18Rik; Acer1; Alkcdase1; Asah3; Cer1", "protein_names_uniprotkb": "Alkaline ceramidase 1; 3.5.1.-; 3.5.1.23; Acylsphingosine deacylase 3; AlkCDase 1; Alkaline CDase 1; N-acylsphingosine amidohydrolase 3; maCER1", "protein_names_refseq": "N-acylsphingosine amidohydrolase 3; acylsphingosine deacylase 3; alkCDase 1; alkaline cdase 1; alkaline ceramidase 1; maCER1", "tax_id": 10090, "disease": "", "pathway": " (mmu:171168); (R-MMU-9845614)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12783875;27126290;29056331;29395079;34428180;39196139", "class_list": "glycogene", "function": "Alkaline ceramidase 1-mediated platelet ceramide catabolism mitigates vascular inflammation and abdominal aortic aneurysm formation. Erratum:[Nat Cardiovasc Res. 2025 Sep;4(9):1206. doi: 10.1038/s44161-025-00720-3. PMID: 40890368], [RefSeq, PubMed]; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH (PubMed:12783875). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:12783875). Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide (PubMed:12783875). May also hydrolyze dihydroceramides to produce dihydrosphingosine (By similarity). ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis (PubMed:27126290, PubMed:29056331)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; In conclusion, the present study unraveled ceramidase as a crucial player in sphingosine-induced platelet activation following GPVI-dependent signaling., [RefSeq, PubMed]; Loss of Acer1 elevated the levels of various ceramides and sphingoid bases in the skin and caused progressive hair loss in mice., [RefSeq, PubMed]; Novel alkaline ceramidase with a stringent substrate specificity and is selectively expressed in skin and may have a role in regulating the levels of bioactive lipids ceramide and sphingosine-1-p, as well as complex sphingolipids., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L3S2", "ec_number_list": "3.5.1.23;3.5.1.-;3.5.1.60", "go_molecular_function": "GO:0046872 metal ion binding;GO:0017040 N-acylsphingosine amidohydrolase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0048733 sebaceous gland development;GO:0030154 cell differentiation;GO:0006665 sphingolipid metabolic process;GO:0010446 response to alkaline pH;GO:0019216 regulation of lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R4X1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VD53-1", "uniprot_id": "ACER2_MOUSE", "mass": 31369.0, "length": 275, "protein_name": "Alkaline ceramidase 2", "gene_name": "Acer2", "organism": "Mouse", "refseq_name": "alkaline ceramidase 2 isoform 2", "refseq_ac": "NP_001277470", "gene_names_uniprotkb": "Acer2; Asah3l", "gene_names_refseq": "2410116I05Rik; Acer2; Asah3l; CRG-L1; maCER2", "protein_names_uniprotkb": "Alkaline ceramidase 2; 3.5.1.-; 3.5.1.23; Acylsphingosine deacylase 3-like; AlkCDase 2; Alkaline CDase 2; CRG-L1; Cancer-related gene liver 1 protein; N-acylsphingosine amidohydrolase 3-like; maCER2", "protein_names_refseq": "alkCDase 2; alkaline CDase 2; alkaline ceramidase 2 isoform 2; cancer related gene-liver 1 (CRG-L1); cancer-related gene liver 1 protein; ceramide hydrolase", "tax_id": 10090, "disease": "", "pathway": " (mmu:230379); (R-MMU-9845614)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11420682;16940153;29401619;30084848;31558682;32959379;34428180;37308908", "class_list": "", "function": "Exosomal miR-125b-5p derived from adipose-derived mesenchymal stem cells enhance diabetic hindlimb ischemia repair via targeting alkaline ceramidase 2. Publication Status: Online-Only, [RefSeq, PubMed]; Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:29401619). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:29401619). Has a better catalytic efficiency towards unsaturated long-chain ceramides, including C18:1-, C20:1- and C24:1-ceramides (By similarity) (PubMed:29401619). Saturated long-chain ceramides and unsaturated very long-chain ceramides are also good substrates, whereas saturated very long-chain ceramides and short-chain ceramides are poor substrates. Also hydrolyzes dihydroceramides to produce dihydrosphingosine (By similarity). It is the ceramidase that controls the levels of circulating sphingosine-1-phosphate and dihydrosphingosine-1-phosphate in plasma through their production by hematopoietic cells (PubMed:29401619). Regulates cell proliferation, autophagy and apoptosis by the production of sphingosine and sphingosine-1-phosphate. As part of a p53/TP53-dependent pathway, promotes for instance autophagy and apoptosis in response to DNA damage. Through the production of sphingosine, may also regulate the function of the Golgi complex and regulate the glycosylation of proteins (By similarity)., [UniProtKB, PubMed, UniProtKB]; Maternal and fetal alkaline ceramidase 2 is required for placental vascular integrity in mice., [RefSeq, PubMed]; Results suggest that ACER2 plays a key role in the maintenance of high plasma levels of sphingoid base-1-phosphates-S1P and dhS1P-by controlling the generation of sphingoid bases-SPH and dhSPH-in hematopoietic cells., [RefSeq, PubMed]; Using genome-wide association analyses, we identified eight gene-containing loci, including a locus containing Acer2, which encodes a ceramidase and is specifically expressed in the collecting duct. Knockout of Acer2 led to increased susceptibility for lithium-induced diabetes insipidus development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PB92;Q8BUG3", "ec_number_list": "3.5.1.23;3.5.1.-;3.5.1.60", "go_molecular_function": "GO:0046872 metal ion binding;GO:0017040 N-acylsphingosine amidohydrolase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0010506 regulation of autophagy;GO:0046512 sphingosine biosynthetic process;GO:0046514 ceramide catabolic process;GO:0071466 cellular response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VD53-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91X60-1", "uniprot_id": "ACHA2_MOUSE", "mass": 58735.0, "length": 512, "protein_name": "Neuronal acetylcholine receptor subunit alpha-2", "gene_name": "Chrna2", "organism": "Mouse", "refseq_name": "neuronal acetylcholine receptor subunit alpha-2 precursor", "refseq_ac": "NP_659052", "gene_names_uniprotkb": "Chrna2", "gene_names_refseq": "Acra-2; Acra2; Chrna2", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-2", "protein_names_refseq": "cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal); neuronal acetylcholine receptor subunit alpha-2 precursor; neuronal acetylcholine receptor subunit alpha-2", "tax_id": 10090, "disease": "autosomal dominant nocturnal frontal lobe epilepsy 4 (Disease Ontology:DOID:0060685); alcohol use disorder (Disease Ontology:DOID:1574); asthma (Disease Ontology:DOID:2841); congenital myasthenic syndrome (Disease Ontology:DOID:3635)", "pathway": " (mmu:110902); (R-MMU-629594); (R-MMU-629597)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "10.1101/2023.09.13.557529", "class_list": "", "function": "Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA2 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4 and plays a role in nicotine dependence., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-;2.7.11.1", "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:1901363 heterocyclic compound binding;GO:0050997 quaternary ammonium group binding", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse", "go_biological_process": "GO:0098828 modulation of inhibitory postsynaptic potential;GO:0007165 signal transduction;GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0035094 response to nicotine", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91X60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LE6-1", "uniprot_id": "ABCF2_MOUSE", "mass": 71782.0, "length": 628, "protein_name": "ATP-binding cassette sub-family F member 2", "gene_name": "Abcf2", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family F member 2 isoform 2", "refseq_ac": "NP_001177372", "gene_names_uniprotkb": "Abcf2", "gene_names_refseq": "0710005O05Rik; Abcf2; Drr3; E430001O06", "protein_names_uniprotkb": "ATP-binding cassette sub-family F member 2", "protein_names_refseq": "ATP-binding cassette sub-family F member 2 isoform 2; ATP-binding cassette, sub-family F (GCN20), member 2; developmentally regulated repeat element-containing transcript 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:27407)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10708515;22872234;31219806;33649389;34428180;35820727;37828378", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UA24;Q8C1S5;Q9JL48", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99LE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LF1-1", "uniprot_id": "AKIR1_MOUSE", "mass": 21676.0, "length": 191, "protein_name": "Akirin-1", "gene_name": "Akirin1", "organism": "Mouse", "refseq_name": "akirin-1", "refseq_ac": "NP_075912", "gene_names_uniprotkb": "Akirin1; MNCb-2831; Mighty", "gene_names_refseq": "6330407G11Rik; Akirin1", "protein_names_uniprotkb": "Akirin-1; protein mighty", "protein_names_refseq": "akirin-1; mighty protein; protein mighty", "tax_id": 10090, "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340)", "pathway": " (mmu:68050)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18066067;18255059;19406121;21183079;23516508;25331329;30746755", "class_list": "", "function": "Glucocorticoids stimulate myostatin which inhibits Akirin1 expression and the reparative functions of satellite cells, [RefSeq, PubMed]; Mighty is a critical promyogenic factor which plays a key role in the signalling pathway downstream of Myostatin., [RefSeq, PubMed]; Molecular adapter that acts as a bridge between proteins, and which is involved skeletal muscle development (PubMed:18255059, PubMed:19406121, PubMed:30746755). Functions as a signal transducer for MSTN during skeletal muscle regeneration and myogenesis (PubMed:18255059, PubMed:19406121). May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway (PubMed:19406121). In contrast to AKIRIN2, not involved in nuclear import of proteasomes (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Myostatin regulates key steps of muscle regeneration including chemotaxis of inflammatory cells, SC activation and migration through akirin1., [RefSeq, PubMed]; That mouse Akhirin plays a crucial role in mouse spinal cord formation by regulating the ependymal niche in the central canal, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJB7", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0000785 chromatin", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0014839 myoblast migration involved in skeletal muscle regeneration;GO:0010592 positive regulation of lamellipodium assembly;GO:0045663 positive regulation of myoblast differentiation;GO:0010759 positive regulation of macrophage chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99LF1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99PG0-1", "uniprot_id": "AAAD_MOUSE", "mass": 45250.0, "length": 398, "protein_name": "Arylacetamide deacetylase", "gene_name": "Aadac", "organism": "Mouse", "refseq_name": "arylacetamide deacetylase", "refseq_ac": "NP_075872", "gene_names_uniprotkb": "Aadac; Aada", "gene_names_refseq": "5033417E09Rik; Aadac; Aada", "protein_names_uniprotkb": "Arylacetamide deacetylase; 3.1.1.3", "protein_names_refseq": "arylacetamide deacetylase (esterase); arylacetamide deacetylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:67758); (R-MMU-211945)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11481320;19654421;22207054;28011936;30084848;34428180;34450168;34798123;36163032;37002641;37453647", "class_list": "glycogene", "function": "AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation. Erratum:[J Exp Clin Cancer Res. 2022 Oct 25;41(1):313. doi: 10.1186/s13046-022-02508-w. PMID: 36280883] Publication Status: Online-Only, [RefSeq, PubMed]; Arylacetamide deacetylase as a determinant of the hydrolysis and activation of abiraterone acetate in mice and humans., [RefSeq, PubMed]; Arylacetamide deacetylase knockout mice are sensitive to ketoconazole-induced hepatotoxicity and adrenal insufficiency., [RefSeq, PubMed]; Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly (By similarity). Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity., [UniProtKB, PubMed, PubMed]; Expression of AADA cDNA in McArdle-RH7777 cells significantly reduced intracellular triacylglycerol levels and apolipoprotein B secretion and increased fatty acid oxidation., [RefSeq, PubMed]; In vitro deacetylation of N-acetylserotonin by arylacetamide deacetylase., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 27, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCF2", "ec_number_list": "3.1.1.32;3.1.1.34;3.1.1.3;3.1.1.26;3.1.1.5;3.1.1.23;3.1.1.79;3.1.1.4;3.1.1.13;3.1.1.6;3.1.1.-;3.1.1.116;2.3.1.51", "go_molecular_function": "GO:0016298 lipase activity;GO:0017171 serine hydrolase activity;GO:0004806 triacylglycerol lipase activity;GO:0019213 deacetylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0010898 positive regulation of triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q99PG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D061-1", "uniprot_id": "ACBD6_MOUSE", "mass": 30887.0, "length": 282, "protein_name": "Acyl-CoA-binding domain-containing protein 6", "gene_name": "Acbd6", "organism": "Mouse", "refseq_name": "acyl-CoA-binding domain-containing protein 6 isoform 2", "refseq_ac": "NP_001139253", "gene_names_uniprotkb": "Acbd6", "gene_names_refseq": "0610010G04Rik; 2610100E10Rik; Acbd6", "protein_names_uniprotkb": "Acyl-CoA-binding domain-containing protein 6", "protein_names_refseq": "acyl-CoA-binding domain-containing protein 6 isoform 2; acyl-CoA-binding domain-containing protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:72482); (R-MMU-77289)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;25428506;30084848;34428180", "class_list": "", "function": "Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids (By similarity). Plays a role in protein N-myristoylation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMN7;Q9DCU4", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding;GO:0000062 fatty-acyl-CoA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D061-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D258-1", "uniprot_id": "ACBD7_MOUSE", "mass": 10011.0, "length": 88, "protein_name": "Acyl-CoA-binding domain-containing protein 7", "gene_name": "Acbd7", "organism": "Mouse", "refseq_name": "acyl-CoA-binding domain-containing protein 7", "refseq_ac": "NP_084339", "gene_names_uniprotkb": "Acbd7", "gene_names_refseq": "9230116B18Rik; Acbd7", "protein_names_uniprotkb": "Acyl-CoA-binding domain-containing protein 7", "protein_names_refseq": "acyl-CoA-binding domain-containing protein 7", "tax_id": 10090, "disease": "cardiovascular system disease (Disease Ontology:DOID:1287)", "pathway": " (mmu:78245); (R-MMU-77289)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;26880548", "class_list": "", "function": "Binds medium- and long-chain acyl-CoA esters., [UniProtKB]; These data suggest that ACBD7-producing neurons are involved in the hypothalamic control exerted on food intake and energy expenditure by the leptin-melanocortin pathway. GeneRIF: This article describes an uncharacterized splice variant of the Acbd7 mRNA. This article also underlines the potential involvement of Acbd7 maturation product as potent anorexigenic neuropeptides. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AJG1", "ec_number_list": "", "go_molecular_function": "GO:0000062 fatty-acyl-CoA binding", "go_cellular_component": "", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0007186 G protein-coupled receptor signaling pathway;GO:0032094 response to food;GO:0097009 energy homeostasis;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D258-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBS4-1", "uniprot_id": "ACOXL_MOUSE", "mass": 70706.0, "length": 632, "protein_name": "Acyl-coenzyme A oxidase-like protein", "gene_name": "Acoxl", "organism": "Mouse", "refseq_name": "acyl-coenzyme A oxidase-like protein", "refseq_ac": "NP_083041", "gene_names_uniprotkb": "Acoxl", "gene_names_refseq": "1200014P05Rik; Acoxl", "protein_names_uniprotkb": "Acyl-coenzyme A oxidase-like protein; 1.3.3.-; Acyl-CoA oxidase-like protein", "protein_names_refseq": "acyl-CoA oxidase-like protein; acyl-coenzyme A oxidase-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:74121); (R-MMU-389887)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "30084848;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZM1", "ec_number_list": "1.3.3.-;1.3.3.6", "go_molecular_function": "GO:0005504 fatty acid binding;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0003997 acyl-CoA oxidase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DBS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCQ7-1", "uniprot_id": "A1AT6_MOUSE", "mass": 46337.0, "length": 411, "protein_name": "Alpha-1-antitrypsin 1-6", "gene_name": "Serpina1f", "organism": "Mouse", "refseq_name": "alpha-1-antitrypsin 1-6 isoform 2 precursor", "refseq_ac": "NP_001158214", "gene_names_uniprotkb": "Serpina1f", "gene_names_refseq": "0610012A11Rik; Serpina1f; Serpina2; epserin", "protein_names_uniprotkb": "Alpha-1-antitrypsin 1-6; Alpha-1 protease inhibitor 6; Alpha-1-antiproteinase; Serine protease inhibitor 1-6; Serine protease inhibitor A1f; Serpin A1f", "protein_names_refseq": "alpha-1 protease inhibitor 6; alpha-1-antiproteinase; alpha-1-antitrypsin 1-6 isoform 2 precursor; alpha-1-antitrypsin 1-6; epididymal serine protease inhibitor; epsin; serine protease inhibitor 1-6; serine protease inhibitor A1f; serpin A1f", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831)", "pathway": " (mmu:68348)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16707773;21750661;30084848", "class_list": "", "function": "Inhibitor of serine proteases., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3LFT1;Q3TNC2", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DCQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHJ5-1", "uniprot_id": "5HT3B_MOUSE", "mass": 50321.0, "length": 437, "protein_name": "5-hydroxytryptamine receptor 3B", "gene_name": "Htr3b", "organism": "Mouse", "refseq_name": "5-hydroxytryptamine receptor 3B precursor", "refseq_ac": "NP_064670", "gene_names_uniprotkb": "Htr3b", "gene_names_refseq": "5-HT3B; Htr3b", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 3B; 5-HT3-B; 5-HT3B; Serotonin receptor 3B", "protein_names_refseq": "5-HT3 receptor subunit B; 5-HT3-B; 5-hydroxytryptamine receptor 3B precursor; 5-hydroxytryptamine receptor 3B; serotonin receptor 3B", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:57014); (R-MMU-112314)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10854267;12388212;12623220;17607564", "class_list": "", "function": "5-HT mediates enhanced neurogenic contractions of the mouse bladder muscle by an action at 5-HT(3) receptors. The presence of the 5-HT(3) receptor was confirmed by the expression of both 5-HT(3A) and 5-HT(3B) receptor subunits., [RefSeq, PubMed]; Adaptive changes occur in the subunit composition of enteric 5-HT(3) receptors of 5-HT transporter -/- mice that are reflected in 5-HT(3) receptor affinity and desensitization, [RefSeq, PubMed]; Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons., [UniProtKB, UniProtKB]; The 5-HT3B subunit alters the functional properties of 5-HT3 receptors native to neuroblastoma cells.(rat 5-Ht3B), [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-;2.7.11.1", "go_molecular_function": "GO:0022850 serotonin-gated monoatomic cation channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0007268 chemical synaptic transmission;GO:0034220 monoatomic ion transmembrane transport;GO:0007210 serotonin receptor signaling pathway;GO:0032414 positive regulation of ion transmembrane transporter activity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JHJ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERK7-1", "uniprot_id": "ACHB2_MOUSE", "mass": 57113.0, "length": 501, "protein_name": "Neuronal acetylcholine receptor subunit beta-2", "gene_name": "Chrnb2", "organism": "Mouse", "refseq_name": "neuronal acetylcholine receptor subunit beta-2 precursor", "refseq_ac": "NP_033732", "gene_names_uniprotkb": "Chrnb2", "gene_names_refseq": "Acrb-2; Acrb2; C030030P04Rik; Chrnb2; [b]2-nAchR", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit beta-2", "protein_names_refseq": "acetylcholine receptor beta 2 neural; cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal); neuronal acetylcholine receptor subunit beta-2 precursor; neuronal acetylcholine receptor subunit beta-2", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant nocturnal frontal lobe epilepsy (Disease Ontology:DOID:0060681); autosomal dominant nocturnal frontal lobe epilepsy 3 (Disease Ontology:DOID:0060684); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); alcohol use disorder (Disease Ontology:DOID:1574); congenital myasthenic syndrome (Disease Ontology:DOID:3635)", "pathway": " (mmu:11444); (R-MMU-629587); (R-MMU-629594); (R-MMU-629597)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;11434511;21750661", "class_list": "", "function": "Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNB2 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3, CHRNA4 and CHRNA6, as well as CHRNA5 and CHRNB3 as accesory subunits. Found in two major stoichiometric forms,(CHRNA4)3:(CHRNB2)2 and (CHRNA4)2:(CHRNB2)3, the two stoichiometric forms differ in their unitary conductance, calcium permeability, ACh sensitivity and potentiation by divalent cation (By similarity). Heteropentameric channels with CHRNA6 and CHRNA4 exhibit high sensitivity to ACh and nicotine and are predominantly expressed in only a few brain areas, including dopaminergic neurons, norepirephrine neurons and cells of the visual system. nAChrs containing CHRNA6 subunits mediate endogenous cholinergic modulation of dopamine and gamma-aminobutyric acid (GABA) release in response to nicotine at nerve terminals (By similarity). Also forms functional nAChRs with other subunits such as CHRNA7:CHRNB2, mainly expressed in basal forebrain cholinergic neurons (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGP7", "ec_number_list": "1.8.-.-;2.7.11.1", "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0042166 acetylcholine binding;GO:0044877 protein-containing complex binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0044853 plasma membrane raft;GO:0045202 synapse", "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0007165 signal transduction;GO:0007271 synaptic transmission, cholinergic;GO:0007612 learning;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9ERK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55137-1", "uniprot_id": "ACOT1_MOUSE", "mass": 46136.0, "length": 419, "protein_name": "Acyl-coenzyme A thioesterase 1", "gene_name": "Acot1", "organism": "Mouse", "refseq_name": "acyl-coenzyme A thioesterase 1", "refseq_ac": "NP_036136", "gene_names_uniprotkb": "Acot1; Cte1", "gene_names_refseq": "ACH2; Acot1; CTE-1; CTE-I; Cte1; D12Ucla1", "protein_names_uniprotkb": "Acyl-coenzyme A thioesterase 1; 3.1.2.-; 3.1.2.2; Acyl-CoA thioesterase 1; CTE-I; Inducible cytosolic acyl-coenzyme A thioester hydrolase; Long chain acyl-CoA hydrolase; Long chain acyl-CoA thioester hydrolase; Palmitoyl-coenzyme A thioesterase", "protein_names_refseq": "acyl-CoA thioesterase 1, cytosolic; acyl-coenzyme A thioesterase 1; cytosolic acyl-CoA thioesterase 1; inducible cytosolic acyl-coenzyme A thioester hydrolase; long chain acyl-CoA hydrolase; long chain acyl-CoA thioester hydrolase; palmitoyl-coenzyme A thioesterase", "tax_id": 10090, "disease": "", "pathway": " (mmu:26897); (R-MMU-77289); (R-MMU-9033241); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10567408;11330065;11694534;21750661;28135057;37561578;9490035", "class_list": "", "function": "ACOT1 deficiency attenuates high-fat diet-induced fat mass gain by increasing energy expenditure. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q549A9", "ec_number_list": "2.3.2.27;3.5.3.1;1.8.1.4;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;5.1.99.4;2.6.1.51;2.6.1.44;3.1.2.2;5.3.3.21;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.1.2.-;3.1.2.22;3.4.21.92;1.1.1.42;1.1.1.37;3.6.1.-;3.6.1.77;1.4.3.3;4.98.1.1;1.11.1.6;1.4.1.3;1.14.13.39;2.3.1.176;2.3.1.16;2.3.1.155;1.2.4.1;4.1.3.4;3.6.4.10;5.3.3.8;1.2.1.3;2.3.1.137;2.3.1.7;2.3.1.168;2.3.3.10;2.3.2.36;7.1.2.2;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;5.6.1.7;4.2.1.2;3.1.1.4;3.1.1.5;2.3.1.42;1.2.4.2;1.1.1.30;2.7.11.2;6.1.1.5;3.5.2.6;2.3.1.9;1.5.3.13;2.7.1.23;3.4.21.53;5.6.2.3;3.1.2.14;2.3.1.37;7.1.1.2;2.3.1.65;1.4.3.1;4.1.1.9;1.1.1.38;4.2.1.3;1.1.1.300;1.1.1.184;6.4.1.3;1.3.1.38;1.2.1.36;1.7.1.-;1.2.1.28;2.3.3.1;2.8.3.5;2.3.1.41;1.1.1.41;1.3.8.5;1.5.3.1;1.5.3.7;3.4.21.-;1.3.8.1;2.5.1.18;1.3.3.6;3.4.24.56;1.1.3.15;4.1.2.63;1.2.3.5;1.3.1.124;6.2.1.4", "go_molecular_function": "GO:0047617 fatty acyl-CoA hydrolase activity;GO:0052689 carboxylic ester hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0006631 fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process;GO:0010667 negative regulation of cardiac muscle cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O55137-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AKE7-1", "uniprot_id": "ACL10_MOUSE", "mass": 37759.0, "length": 346, "protein_name": "Actin-like protein 10", "gene_name": "Actl10", "organism": "Mouse", "refseq_name": "actin-like protein 10", "refseq_ac": "NP_001165111", "gene_names_uniprotkb": "Actl10", "gene_names_refseq": "1700007I08Rik; Actl10", "protein_names_uniprotkb": "Actin-like protein 10", "protein_names_refseq": "actin-like protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:70362)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0015629 actin cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2AKE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WC3-1", "uniprot_id": "ACSL6_MOUSE", "mass": 78017.0, "length": 697, "protein_name": "Long-chain-fatty-acid--CoA ligase 6", "gene_name": "Acsl6", "organism": "Mouse", "refseq_name": "long-chain-fatty-acid--CoA ligase 6 isoform 3", "refseq_ac": "NP_001028770", "gene_names_uniprotkb": "Acsl6; Facl6", "gene_names_refseq": "A330035H04Rik; Acsl6; Facl6; LACS; Lacsl; mKIAA0837", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase 6; 6.2.1.15; 6.2.1.3; Arachidonate--CoA ligase; LACS 6; Long-chain acyl-CoA synthetase 6", "protein_names_refseq": "LACS 6; arachidonate--CoA ligase; fatty acid Coenzyme A ligase, long chain 6; long-chain acyl-CoA synthetase 6; long-chain-fatty-acid--CoA ligase 6 isoform 3; long-chain-fatty-acid--CoA ligase 6", "tax_id": 10090, "disease": "leukemia (Disease Ontology:DOID:1240); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:216739); (R-MMU-75876)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12767919;21750661;33300544;34428180;35976155;37585289;37828378;39169121", "class_list": "", "function": "Acyl-CoA synthetase 6 controls rod photoreceptor function and survival by shaping the phospholipid composition of retinal membranes. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid (By similarity)., [UniProtKB, UniProtKB]; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation., [UniProtKB, UniProtKB]; Ectopic Acsl6 Overexpression Partially Improves Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte Hypertrophy In Vitro. Publication Status: Online-Only, [RefSeq, PubMed]; Long chain acyl-CoA synthetase 6 facilitates the local distribution of di-docosahexaenoic acid- and ultra-long-chain-PUFA-containing phospholipids in the retina to support normal visual function in mice., [RefSeq, PubMed]; Long-chain acyl-CoA synthetase expressed in brain participates in neuronal cell proliferation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZF1", "ec_number_list": "6.2.1.3;6.2.1.-;6.2.1.15;6.2.1.7;6.2.1.24;6.2.1.2;6.2.1.25", "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0047676 arachidonate-CoA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0010976 positive regulation of neuron projection development;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91WC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQJ0-1", "uniprot_id": "THEM5_MOUSE", "mass": 27865.0, "length": 248, "protein_name": "Acyl-coenzyme A thioesterase THEM5", "gene_name": "Them5", "organism": "Mouse", "refseq_name": "acyl-coenzyme A thioesterase THEM5", "refseq_ac": "NP_079692", "gene_names_uniprotkb": "Them5; Acot15", "gene_names_refseq": "1110007B02Rik; 1110038F21Rik; Them5", "protein_names_uniprotkb": "Acyl-coenzyme A thioesterase THEM5; 3.1.2.2; Acyl-CoA thioesterase THEM5; Acyl-coenzyme A thioesterase 15; Thioesterase superfamily member 5", "protein_names_refseq": "acyl-CoA thioesterase THEM5; acyl-coenzyme A thioesterase 15; acyl-coenzyme A thioesterase THEM5", "tax_id": 10090, "disease": "", "pathway": " (mmu:66198); (R-MMU-77289)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;22586271;34428180", "class_list": "", "function": "Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-chain fatty acid-CoA esters (By similarity). Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin (PubMed:22586271). Required for normal mitochondrial function (PubMed:22586271)., [UniProtKB, UniProtKB, PubMed]; Loss of Them5 specifically alters the remodeling process of the mitochondrial phospholipid cardiolipin. Them5(-/-) mice show deregulation of lipid metabolism and the development of fatty liver, exacerbated by a high-fat diet., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CTI2", "ec_number_list": "3.1.2.2;3.1.2.-;3.1.2.22;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;3.1.1.4;3.1.1.5;3.5.2.6;2.3.1.16;2.3.1.9;3.1.2.14;2.3.1.65", "go_molecular_function": "GO:0052816 long-chain fatty acyl-CoA hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0035336 long-chain fatty-acyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQJ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QUJ7-1", "uniprot_id": "ACSL4_MOUSE", "mass": 79077.0, "length": 711, "protein_name": "Long-chain-fatty-acid--CoA ligase 4", "gene_name": "Acsl4", "organism": "Mouse", "refseq_name": "long-chain-fatty-acid--CoA ligase 4 isoform 2", "refseq_ac": "NP_001028772", "gene_names_uniprotkb": "Acsl4; Acs4; Facl4", "gene_names_refseq": "9430020A05Rik; ACS4; Acsl4; Facl4; Lacs4", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase 4; 6.2.1.15; 6.2.1.3; Arachidonate--CoA ligase; LACS 4; Long-chain acyl-CoA synthetase 4; mACS4", "protein_names_refseq": "LACS 4; arachidonate--CoA ligase; fatty acid-Coenzyme A ligase, long chain 4; long-chain acyl-CoA synthetase 4; long-chain-fatty-acid--CoA ligase 4 isoform 2; long-chain-fatty-acid--CoA ligase 4; mACS4", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); non-syndromic X-linked intellectual disability 63 (Disease Ontology:DOID:0112050); intellectual disability (Disease Ontology:DOID:1059); Sjogren-Larsson syndrome (Disease Ontology:DOID:14501)", "pathway": " (mmu:50790); (R-MMU-434313); (R-MMU-75876)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10828604;10924347;25605945;30084848;31219806;34203471;34428180", "class_list": "", "function": "Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET (By similarity). Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion. Acts as an activator of ferroptosis by activating polyunsaturated fatty acids, especially arachidonate and adrenate, to their active form, generating the primary lipid-peroxidation substrates that contribute to ferroptosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5D071;Q9JHT4;Q9R0H3", "ec_number_list": "6.2.1.3;6.2.1.-;6.2.1.15;6.2.1.7;6.2.1.24;6.2.1.2;6.2.1.25", "go_molecular_function": "GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0031957 very long-chain fatty acid-CoA ligase activity;GO:0047676 arachidonate-CoA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0006629 lipid metabolic process;GO:0006631 fatty acid metabolic process;GO:0008610 lipid biosynthetic process;GO:0030307 positive regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QUJ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0W9-1", "uniprot_id": "ACHA6_MOUSE", "mass": 56856.0, "length": 494, "protein_name": "Neuronal acetylcholine receptor subunit alpha-6", "gene_name": "Chrna6", "organism": "Mouse", "refseq_name": "neuronal acetylcholine receptor subunit alpha-6 precursor", "refseq_ac": "NP_067344", "gene_names_uniprotkb": "Chrna6; Nica6", "gene_names_refseq": "Acra6; Chrna6; Nica6", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-6", "protein_names_refseq": "acetylcholine receptor alpha 6 neural; alpha6 nAChR; neuronal acetylcholine receptor subunit alpha-6 precursor; neuronal acetylcholine receptor subunit alpha-6; nicotinic acetylcholine receptor subunit alpha 6", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); alcohol use disorder (Disease Ontology:DOID:1574); cocaine abuse (Disease Ontology:DOID:809)", "pathway": " (mmu:11440); (R-MMU-629594); (R-MMU-629597)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12944511;21325521;22836257;24266758;32776643", "class_list": "", "function": "Bidirectional sex-dependent regulation of alpha6 and beta3 nicotinic acetylcholine receptors by protein kinase Cepsilon., [RefSeq, PubMed]; Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:12944511, PubMed:21325521, PubMed:22836257, PubMed:24266758). CHRNA6 forms pentameric channels with CHRNB2 and CHRNA4 that exhibit high sensitivity to ACh and nicotine and are predominantly expressed in only a few brain areas, including dopaminergic neurons, norepirephrine neurons and cells of the visual system (PubMed:12944511, PubMed:21325521, PubMed:22836257, PubMed:24266758). nAChrs containing CHRNA6 subunits mediate endogenous cholinergic modulation of dopamine and gamma-aminobutyric acid (GABA) release in response to nicotine at nerve terminals (PubMed:12944511, PubMed:21325521, PubMed:22836257, PubMed:24266758)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEY4;Q8K0A7", "ec_number_list": "1.8.-.-;2.7.11.1", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0035094 response to nicotine;GO:0035095 behavioral response to nicotine;GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9R0W9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0X4-1", "uniprot_id": "ACOT9_MOUSE", "mass": 50560.0, "length": 439, "protein_name": "Acyl-coenzyme A thioesterase 9, mitochondrial", "gene_name": "Acot9", "organism": "Mouse", "refseq_name": "acyl-coenzyme A thioesterase 9, mitochondrial isoform 1", "refseq_ac": "NP_062710", "gene_names_uniprotkb": "Acot9; Acate2", "gene_names_refseq": "0610041P13Rik; Acate2; Acot9; MT-ACT48; MTE-2; U8; p48", "protein_names_uniprotkb": "Acyl-coenzyme A thioesterase 9, mitochondrial; 3.1.2.-; 3.1.2.2; Acyl coenzyme A thioester hydrolase 2; Acyl-CoA thioester hydrolase 9; Acyl-CoA thioesterase 9; MT-ACT48.1; MTE-2; Mitochondrial 48 kDa acyl-CoA thioester hydrolase 1; Protein U8; p48", "protein_names_refseq": "acyl coenzyme A thioester hydrolase 2; acyl-CoA thioester hydrolase 9; acyl-Coenzyme A thioesterase 2, mitochondrial; acyl-coenzyme A thioesterase 9, mitochondrial isoform 1; acyl-coenzyme A thioesterase 9, mitochondrial; mitochondrial 48 kDa acyl-CoA thioester hydrolase 1; mitochondrial acyl-CoA thioesterase; protein U8", "tax_id": 10090, "disease": "", "pathway": " (mmu:56360); (R-MMU-77289)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10383425;21750661;21946561;23864032;24788674;26495903;28011936;28135057;28528544;31676684;32498134;37507081;37828378", "class_list": "", "function": "Acyl-CoA thioesterase 9 (ACOT9) in mouse may provide a novel link between fatty acid and amino acid metabolism in mitochondria., [RefSeq, PubMed]; Mitochondrial acyl-CoA thioesterase. Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoA), regulating their respective intracellular levels (PubMed:10383425, PubMed:23864032). Shows a clear preference for hydrophobic short-, medium-, and long-chain saturated acyl-CoAs with some activity also with short-chain dicarboxylic CoA esters (PubMed:10383425, PubMed:23864032). Regulates both mitochondrial lipid and amino acid metabolism (PubMed:23864032, PubMed:31676684, PubMed:32498134)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q545G7;Q9WTJ0;Q9WUZ8", "ec_number_list": "3.1.2.2;3.1.2.-;3.1.2.22;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;3.1.1.4;3.1.1.5;3.5.2.6;2.3.1.16;2.3.1.9;3.1.2.14;2.3.1.65", "go_molecular_function": "GO:0003986 acetyl-CoA hydrolase activity;GO:0047617 fatty acyl-CoA hydrolase activity;GO:0052689 carboxylic ester hydrolase activity;GO:0052816 long-chain fatty acyl-CoA hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process;GO:0046459 short-chain fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9R0X4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3X982-1", "uniprot_id": "AOXC_MOUSE", "mass": 146902.0, "length": 1335, "protein_name": "Aldehyde oxidase 3", "gene_name": "Aox3", "organism": "Mouse", "refseq_name": "aldehyde oxidase 3", "refseq_ac": "NP_076106", "gene_names_uniprotkb": "Aox3; Aoh1", "gene_names_refseq": "1200011D03Rik; Aoh1; Aoh2; Aox3", "protein_names_uniprotkb": "Aldehyde oxidase 3; 1.17.3.-; 1.2.3.1; Aldehyde oxidase homolog 1; Azaheterocycle hydroxylase 3", "protein_names_refseq": "aldehyde oxidase 1; aldehyde oxidase 3; aldehyde oxidase homolog 1; aldehyde oxidase structural homolog 2; azaheterocycle hydroxylase 3", "tax_id": 10090, "disease": "xanthinuria (Disease Ontology:DOID:0060236)", "pathway": " (mmu:71724)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11562361;15383531;18981221;21705476;21750661;23019336;23263164;25287365;25428506;34428180;35820727;37453647", "class_list": "", "function": "Although mAOX2 and mAOX3 are very similar to each other, we propose the following pairs of overlapping substrate specificities: mAOX2/mAOX4 and mAOX3/mAXO1., [RefSeq, PubMed]; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and phthalazine, as well as aldehydes, such as benzaldehyde, retinal and pyridoxal. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSI5;Q8VI15", "ec_number_list": "1.17.3.-;1.2.3.1", "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0005506 iron ion binding;GO:0009055 electron transfer activity;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006805 xenobiotic metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "G3X982-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923X1-1", "uniprot_id": "AGRL4_MOUSE", "mass": 82246.0, "length": 739, "protein_name": "Adhesion G protein-coupled receptor L4", "gene_name": "Adgrl4", "organism": "Mouse", "refseq_name": "adhesion G protein-coupled receptor L4 precursor", "refseq_ac": "NP_573485", "gene_names_uniprotkb": "Adgrl4; Eltd1", "gene_names_refseq": "1110033N21Rik; Adgrl4; ETL1; Eltd1; Etl", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor L4; EGF, latrophilin seven transmembrane domain-containing protein 1", "protein_names_refseq": "EGF, latrophilin seven transmembrane domain containing 1; EGF, latrophilin seven transmembrane domain-containing protein 1; EGF-TM7 receptor; adhesion G protein-coupled receptor L4 precursor", "tax_id": 10090, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (mmu:170757)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11438738;21750661;22606234;23871637;28806758;34347079", "class_list": "", "function": "ELTD1 deficiency exacerbates cardiac hypertrophy and cardiac function induced by aortic banding-induced pressure overload by promoting both cardiomyocyte hypertrophy and cardiac fibrosis., [RefSeq, PubMed]; ELTD1 deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma., [RefSeq, PubMed]; Endothelial orphan receptor that acts as a key regulator of angiogenesis., [UniProtKB, UniProtKB, PubMed]; Loss of GPR116 and ELTD1 expressed by other cells accounts for the observed cardiovascular and renal defects. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "E9QLT4;Q91W44", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0051965 positive regulation of synapse assembly;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q923X1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2RT91-1", "uniprot_id": "ANKAR_MOUSE", "mass": 165290.0, "length": 1465, "protein_name": "Ankyrin and armadillo repeat-containing protein", "gene_name": "Ankar", "organism": "Mouse", "refseq_name": "ankyrin and armadillo repeat-containing protein isoform 1", "refseq_ac": "NP_795954", "gene_names_uniprotkb": "Ankar", "gene_names_refseq": "4932422E22Rik; Ankar", "protein_names_uniprotkb": "Ankyrin and armadillo repeat-containing protein", "protein_names_refseq": "ankyrin and armadillo repeat-containing protein isoform 1; ankyrin and armadillo repeat-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:319695)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0Q1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2RT91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P68134-1", "uniprot_id": "ACTS_MOUSE", "mass": 42051.0, "length": 377, "protein_name": "Actin, alpha skeletal muscle", "gene_name": "Acta1", "organism": "Mouse", "refseq_name": "actin, alpha skeletal muscle", "refseq_ac": "NP_001258970", "gene_names_uniprotkb": "Acta1; Acta", "gene_names_refseq": "Acta-2; Acta1; Actsk-1; Acts", "protein_names_uniprotkb": "Actin, alpha skeletal muscle; 3.6.4.-; Alpha-actin-1", "protein_names_refseq": "actin, alpha skeletal muscle; alpha-actin-1", "tax_id": 10090, "disease": "aortic dissection (Disease Ontology:DOID:0080685); Baraitser-Winter syndrome 1 (Disease Ontology:DOID:0081112); congenital myopathy 2B (Disease Ontology:DOID:0081339); congenital myopathy 2C (Disease Ontology:DOID:0081340); hypertrophic cardiomyopathy 11 (Disease Ontology:DOID:0110317); autosomal dominant nonsyndromic deafness 20 (Disease Ontology:DOID:0110550); nemaline myopathy 3 (Disease Ontology:DOID:0110927); intestinal atresia (Disease Ontology:DOID:10486); Moyamoya disease (Disease Ontology:DOID:13099); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); nemaline myopathy (Disease Ontology:DOID:3191); congenital structural myopathy (Disease Ontology:DOID:422); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:11459); (R-MMU-390522); (R-MMU-9764561); (R-MMU-9913351); (R-MMU-9958825)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "21540332;21750661;22645316;23911929;3013550;3023820;33300544;33725478;35820727;36173861;37453647;39627609;39927985", "class_list": "", "function": "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P02568;P99020", "ec_number_list": "3.6.4.13;3.6.4.10;2.3.2.31;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.2;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;2.3.2.26;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0001725 stress fiber", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0030240 skeletal muscle thin filament assembly;GO:0048741 skeletal muscle fiber development;GO:0090131 mesenchyme migration", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P68134-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WR5-1", "uniprot_id": "AK1CL_MOUSE", "mass": 36877.0, "length": 323, "protein_name": "Aldo-keto reductase family 1 member C21", "gene_name": "Akr1c21", "organism": "Mouse", "refseq_name": "aldo-keto reductase family 1 member C21", "refseq_ac": "NP_084177", "gene_names_uniprotkb": "Akr1c21", "gene_names_refseq": "9430025F20Rik; Akr1c21", "protein_names_uniprotkb": "Aldo-keto reductase family 1 member C21; 1.1.1.-; 1.1.1.209; 17-alpha-HSD; 17-alpha-hydroxysteroid dehydrogenase; 3(or 17)-alpha-hydroxysteroid dehydrogenase; 3-alpha-hydroxysteroid dehydrogenase; DD1; DD3; Dihydrodiol dehydrogenase type 1; Dihydrodiol dehydrogenase type 3", "protein_names_refseq": "17-alpha-HSD; 17-alpha-hydroxysteroid dehydrogenase; 3(17)alpha-hydroxysteroid dehydrogenase; 3(or 17)-alpha-hydroxysteroid dehydrogenase; 3-alpha-hydroxysteroid dehydrogenase; DD1; DD3; aldo-keto reductase family 1 member C21; dihydrodiol dehydrogenase type 1; dihydrodiol dehydrogenase type 3", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); ductal carcinoma in situ (Disease Ontology:DOID:0060074); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); 46,XY sex reversal 8 (Disease Ontology:DOID:0111773); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); leukemia (Disease Ontology:DOID:1240); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:77337); (R-MMU-193368); (R-MMU-193775); (R-MMU-193807); (R-MMU-2162123); (R-MMU-5365859); (R-MMU-975634); (R-MMU-9757110)", "pathway_count": 8, "publication_count": 10, "publication_id_list": "15577209;16018803;16511129;17034817;17442338;17909281;19237748;20124700;21750661;34428180", "class_list": "", "function": "Crystal structure of the m17alpha-HSD enzyme in its apo-form (1.9 A resolution) as well as those of two different forms of this enzyme in binary complex with NADP(H) (2.9 A and 1.35 A resolution)(, [RefSeq, PubMed]; Gly225 & Gly226 help determine the substrate stereospecificity. The G225P/G226P mutation reduced the affinity for both 3alpha- & 17alpha-hydroxysteroid substrates by up to 160-fold, indicating that these residues are critical for substrate binding., [RefSeq, PubMed]; Mutation resulted in a change in the conformation of the flexible loop B, including the V-shaped groove, which is a unique feature of the active-site architecture of wild-type AKR1C21 and is formed by the side chains of Tyr224 and Trp227., [RefSeq, PubMed]; NADP-dependent 17-alpha-hydroxysteroid dehydrogenase that converts 5-alpha-androstane-3,17-dione into androsterone. Has lower 3-alpha-hydroxysteroid dehydrogenase activity. Has broad substrate specificity and acts on various 17-alpha-hydroxysteroids, 17-ketosteroids, 3-alpha hydroxysteroids and 3-ketosteroids. Reduction of keto groups is strictly stereoselective. Reduction of 17-ketosteroids yields only 17-alpha-hydroxysteroids. Likewise, reduction of 3-ketosteroids yields only 3-alpha-hydroxysteroids., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Study reports a ternary complex crystal structure (m17alpha-HSD:NADP(+):epi-T) determined at 1.85 A resolution reveals a unique steroid-binding mode for an AKR enzyme, [RefSeq, PubMed]; X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P8V0;Q9CX32", "ec_number_list": "1.1.1.21;1.1.1.105;1.1.1.315;1.1.1.209;1.1.1.53;1.1.1.-;1.1.1.149;1.1.-.-;1.1.1.62;1.1.1.239", "go_molecular_function": "GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:0004032 aldose reductase (NADPH) activity;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0031406 carboxylic acid binding;GO:0001758 retinal dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0006693 prostaglandin metabolic process;GO:0006694 steroid biosynthetic process;GO:0044597 daunorubicin metabolic process;GO:0044598 doxorubicin metabolic process;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91WR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AJA7-1", "uniprot_id": "AEGP_MOUSE", "mass": 134830.0, "length": 1228, "protein_name": "Apical endosomal glycoprotein", "gene_name": "Mamdc4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mamdc4; Aegp; Gm995", "gene_names_refseq": "", "protein_names_uniprotkb": "Apical endosomal glycoprotein; MAM domain-containing protein 4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:381352)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2AJA6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005768 endosome;GO:0016020 membrane;GO:1990909 Wnt signalosome", "go_biological_process": "GO:0007399 nervous system development;GO:0015031 protein transport;GO:0016055 Wnt signaling pathway;GO:0034504 protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2AJA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ALI5-1", "uniprot_id": "AJAP1_MOUSE", "mass": 44772.0, "length": 412, "protein_name": "Adherens junction-associated protein 1", "gene_name": "Ajap1", "organism": "Mouse", "refseq_name": "adherens junction-associated protein 1 precursor", "refseq_ac": "NP_001092769", "gene_names_uniprotkb": "Ajap1; Gm573", "gene_names_refseq": "Ajap1; Gm573", "protein_names_uniprotkb": "Adherens junction-associated protein 1", "protein_names_refseq": "adherens junction-associated protein 1 precursor; likely ortholog of H. sapiens transmembrane protein SHREW1", "tax_id": 10090, "disease": "", "pathway": " (mmu:230959)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31219806;32067740;38985877", "class_list": "", "function": "AJAP1 affects behavioral changes and GABABR1 level in epileptic mice., [RefSeq, PubMed]; Monoallelic de novo AJAP1 loss-of-function variants disrupt trans-synaptic control of neurotransmitter release., [RefSeq, PubMed]; Plays a role in cell adhesion and cell migration., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RVK0", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0044877 protein-containing complex binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0001953 negative regulation of cell-matrix adhesion;GO:0061045 negative regulation of wound healing;GO:0030860 regulation of polarized epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2ALI5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AM29-1", "uniprot_id": "AF9_MOUSE", "mass": 63375.0, "length": 569, "protein_name": "Protein AF-9", "gene_name": "Mllt3", "organism": "Mouse", "refseq_name": "protein AF-9 isoform 1", "refseq_ac": "NP_081602", "gene_names_uniprotkb": "Mllt3; Af9", "gene_names_refseq": "2210011H10Rik; 2610012I03Rik; 3830408D16Rik; Af9; D4Ertd321e; Mllt3", "protein_names_uniprotkb": "Protein AF-9; ALL1-fused gene from chromosome 9 protein; Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog", "protein_names_refseq": "ALL1-fused gene from chromosome 9 protein; myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog; protein AF-9 isoform 1; protein AF-9; translocated to, 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:70122); (R-MMU-112382); (R-MMU-674695); (R-MMU-75955)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "11439343;12242306;16636056;21183079;21750661;31219806;32549410;32768438;33928666", "class_list": "", "function": "Af9 gene is required for normal embryogenesis in mice by controlling pattern formation, apparently via control of Hox gene regulation, [RefSeq, PubMed]; CRISPR Gene Editing of Murine Blood Stem and Progenitor Cells Induces MLL-AF9 Chromosomal Translocation and MLL-AF9 Leukaemogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (By similarity). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (By similarity). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (By similarity). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (By similarity). Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3 (By similarity). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (By similarity). Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me) (By similarity). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than conferring, HSC stemness (By similarity). Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L (By similarity). Required for DOT1L-mediated H3K79 hypermethylation at the SCNN1A promoter, resulting in transcriptional repression (PubMed:16636056). May play a role in leukemogenic gene transcription (By similarity)., [UniProtKB, UniProtKB, PubMed]; Heritable genetic background alters survival and phenotype of Mll-AF9-induced leukemias., [RefSeq, PubMed]; The Transcriptional Coactivator, ALL1-Fused Gene From Chromosome 9, Simultaneously Sustains Hypoxia Tolerance and Metabolic Advantages in Liver Cancer., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VDR6;Q99MK4", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0042393 histone binding;GO:0140030 modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0008023 transcription elongation factor complex;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0060218 hematopoietic stem cell differentiation;GO:0045893 positive regulation of DNA-templated transcription;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A2AM29-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CJF9-1", "uniprot_id": "AGO3_MOUSE", "mass": 97277.0, "length": 860, "protein_name": "Protein argonaute-3", "gene_name": "Ago3", "organism": "Mouse", "refseq_name": "protein argonaute-3", "refseq_ac": "NP_700451", "gene_names_uniprotkb": "Ago3; Eif2c3", "gene_names_refseq": "Ago3; C130014L07Rik; Eif2c3", "protein_names_uniprotkb": "Protein argonaute-3; 3.1.26.n2; Argonaute RISC catalytic component 3; Argonaute3; Eukaryotic translation initiation factor 2C 3; Piwi/argonaute family protein meIF2C3; eIF-2C 3; eIF2C 3; mAgo3", "protein_names_refseq": "Piwi/Argonaute family protein meIF2C3; argonaute 3; argonaute RISC catalytic component 3; argonaute3; eIF-2C 3; eIF2C 3; eukaryotic translation initiation factor 2C, 3; mAgo3; protein argonaute-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:214150); (R-MMU-203927); (R-MMU-426486); (R-MMU-426496)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "12526743;19174539;21750661;22872234;38096048;39927985", "class_list": "", "function": "Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain type 2 immunity., [RefSeq, PubMed]; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4 (PubMed:19174539). Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity (By similarity)., [UniProtKB, PubMed, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBP7", "ec_number_list": "3.6.4.13;5.6.2.5;3.1.26.n2;3.1.26.3", "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0003727 single-stranded RNA binding;GO:0035198 miRNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0010628 positive regulation of gene expression;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0006402 mRNA catabolic process;GO:0031054 pre-miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CJF9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A8VU90-1", "uniprot_id": "ANKL1_MOUSE", "mass": 58441.0, "length": 534, "protein_name": "Structure-specific endonuclease ANKLE1", "gene_name": "Ankle1", "organism": "Mouse", "refseq_name": "structure-specific endonuclease ANKLE1 isoform 2", "refseq_ac": "NP_001297431", "gene_names_uniprotkb": "Ankle1; Ankrd41; Lem3", "gene_names_refseq": "8430438L13Rik; Ankle1; Ankrd41; C430003I23; Lem3", "protein_names_uniprotkb": "Structure-specific endonuclease ANKLE1; 3.1.-.-; Ankyrin repeat and LEM domain-containing protein 1; Ankyrin repeat domain-containing protein 41; LEM-domain containing protein 3", "protein_names_refseq": "LEM-domain containing 3; LEM-domain containing protein 3; ankyrin repeat and LEM domain-containing protein 1; ankyrin repeat domain 41; ankyrin repeat domain-containing protein 41; structure-specific endonuclease ANKLE1 isoform 2; structure-specific endonuclease ANKLE1", "tax_id": 10090, "disease": "", "pathway": " (mmu:234396)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "27010503", "class_list": "", "function": "Lack of Ankle1 does neither affect mouse hematopoiesis nor DNA damage repair in mouse embryonic fibroblasts, indicating a redundant or non-essential function of ANKLE1 in mouse Publication Status: Online-Only, [RefSeq, PubMed]; Structure-selective DNA endonuclease that specifically cleaves branched DNA. Processes chromatin bridges during cytokinesis by cleaving DNA, both priming TREX1-mediated resolution and directly resolving bridges. Proper processing of chromatin bridges prevents their breakage during cytokinesis, thereby reducing DNA damage, micronuclei formation, and the activation of immune responses such as the cGAS-STING pathway. Acts as a DNA tension sensor that resolves stretched chromatin bridges during cell division by cleaving mechanically stressed and supercoiled DNA. Its activity increases in response to mechanical stress and negative supercoiling, specifically cleaving both strands of negatively supercoiled DNA at higher stretching forces., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H5W1;G5E8T1;Q8C4V5;Q8K2N6", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0016787 hydrolase activity;GO:0030145 manganese ion binding;GO:0004519 endonuclease activity;GO:0004520 DNA endonuclease activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030496 midbody", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0051301 cell division;GO:0006974 DNA damage response;GO:0000724 double-strand break repair via homologous recombination;GO:0006611 protein export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A8VU90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB25-1", "uniprot_id": "ALG5_MOUSE", "mass": 36791.0, "length": 324, "protein_name": "Dolichyl-phosphate beta-glucosyltransferase", "gene_name": "Alg5", "organism": "Mouse", "refseq_name": "dolichyl-phosphate beta-glucosyltransferase", "refseq_ac": "NP_079718", "gene_names_uniprotkb": "Alg5", "gene_names_refseq": "1500026A19Rik; 2600005J22Rik; Alg5", "protein_names_uniprotkb": "Dolichyl-phosphate beta-glucosyltransferase; 2.4.1.117; Asparagine-linked glycosylation protein 5 homolog; DolP-glucosyltransferase", "protein_names_refseq": "Alg5 homolog; asparagine-linked glycosylation 5 (dolichyl-phosphate beta-glucosyltransferase); asparagine-linked glycosylation 5 homolog (yeast, dolichyl-phosphate beta-glucosyltransferase); asparagine-linked glycosylation protein 5 homolog; dolP-glucosyltransferase; dolichyl-phosphate beta-glucosyltransferase", "tax_id": 10090, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); polycystic kidney disease 7 (Disease Ontology:DOID:0060952)", "pathway": " (mmu:66248); (R-MMU-480985)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "glycogene;glycosyltransferase", "function": "Dolichyl-phosphate beta-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Dolichyl-phosphate beta-glucosyltransferase produces dolichyl beta-D-glucosyl phosphate/Dol-P-Glc, the glucose donor substrate used sequentially by ALG6, ALG8 and ALG10 to add glucose residues on top of the Man(9)GlcNAc(2)-PP-Dol structure. These are the three last steps in the biosynthetic pathway of dolichol-linked oligosaccharides to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol. The enzyme is most probably active on the cytoplasmic side of the endoplasmic reticulum while its product Dol-P-Glc is the substrate for ALG6, ALG8 and ALG11 in the lumen of the endoplasmic reticulum., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.117", "go_molecular_function": "GO:0004581 dolichyl-phosphate beta-glucosyltransferase activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005789 endoplasmic reticulum membrane;GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DB25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2J7-1", "uniprot_id": "ANKE1_MOUSE", "mass": 86904.0, "length": 775, "protein_name": "Ankyrin repeat and EF-hand domain-containing protein 1", "gene_name": "Ankef1", "organism": "Mouse", "refseq_name": "ankyrin repeat and EF-hand domain-containing protein 1", "refseq_ac": "NP_783598", "gene_names_uniprotkb": "Ankef1; Ankrd5", "gene_names_refseq": "Ankef1; Ankrd5", "protein_names_uniprotkb": "Ankyrin repeat and EF-hand domain-containing protein 1; Ankyrin repeat domain-containing protein 5", "protein_names_refseq": "ankyrin repeat and EF-hand domain-containing protein 1; ankyrin repeat domain 5; ankyrin repeat domain-containing protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:319196)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VB20", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D2J7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VC28-1", "uniprot_id": "AK1CD_MOUSE", "mass": 37058.0, "length": 323, "protein_name": "Aldo-keto reductase family 1 member C13", "gene_name": "Akr1c13", "organism": "Mouse", "refseq_name": "aldo-keto reductase family 1 member C13 isoform 1", "refseq_ac": "NP_038806", "gene_names_uniprotkb": "Akr1c13", "gene_names_refseq": "Akr1c13; mKIAA4014", "protein_names_uniprotkb": "Aldo-keto reductase family 1 member C13; 1.1.1.-", "protein_names_refseq": "aldo-keto reductase AKR1C13; aldo-keto reductase family 1 member C13 isoform 1", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); ductal carcinoma in situ (Disease Ontology:DOID:0060074); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); 46,XY sex reversal 8 (Disease Ontology:DOID:0111773); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); leukemia (Disease Ontology:DOID:1240); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:27384); (R-MMU-193368); (R-MMU-193775); (R-MMU-193807); (R-MMU-2162123); (R-MMU-5365859); (R-MMU-975634); (R-MMU-9757110)", "pathway_count": 8, "publication_count": 9, "publication_id_list": "10526179;17888864;21750661;26740625;28329705;29764944;30084848;34428180;37453647", "class_list": "", "function": "Akr1c13 functions as a cytosolic sensor for bacterial cyclic dinucleotides, shaping inflammatory gene activation, [RefSeq, PubMed]; Analysis of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases., [RefSeq, PubMed]; Catalyzes the dehydrogenation of 17-beta-hydroxysteroids. May also exhibit significant activity with a variety of cyclic and alicyclic alcohols. Uses both NAD and NADP, but the activity is much greater with NAD than with NADP (By similarity)., [UniProtKB]; Listeria monocytogenes secretion of c-di-AMP inhibits RECON ( Akr1c13) activity, drives augmented NF-kappaB activation and nitric oxide production, and ultimately enhances intercellular spread. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D7R9;Q9R0M9", "ec_number_list": "1.1.1.21;1.1.1.-;1.1.1.149;1.1.-.-;1.1.1.209", "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0031406 carboxylic acid binding;GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0047787 Delta4-3-oxosteroid 5beta-reductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0006693 prostaglandin metabolic process;GO:0044597 daunorubicin metabolic process;GO:0044598 doxorubicin metabolic process;GO:0042448 progesterone metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8VC28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCT3-1", "uniprot_id": "AMPB_MOUSE", "mass": 72416.0, "length": 650, "protein_name": "Aminopeptidase B", "gene_name": "Rnpep", "organism": "Mouse", "refseq_name": "aminopeptidase B isoform 2", "refseq_ac": "NP_001153096", "gene_names_uniprotkb": "Rnpep", "gene_names_refseq": "Rnpep", "protein_names_uniprotkb": "Aminopeptidase B; 3.4.11.6; AP-B; Arginine aminopeptidase; Arginyl aminopeptidase; Cytosol aminopeptidase IV", "protein_names_refseq": "AP-B; aminopeptidase B isoform 2; aminopeptidase B; arginine aminopeptidase; cytosol aminopeptidase IV", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:215615)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15539558;21750661;25605945;33300544;34428180;37507081", "class_list": "", "function": "Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Miniglucagon-generating endopeptidase is composed of NRDc and aminopeptidase B acting sequentially, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TX27", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0005507 copper ion binding;GO:0042277 peptide binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0030141 secretory granule;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0045776 negative regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8VCT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56376-1", "uniprot_id": "ACYP1_MOUSE", "mass": 11241.0, "length": 99, "protein_name": "Acylphosphatase-1", "gene_name": "Acyp1", "organism": "Mouse", "refseq_name": "acylphosphatase-1 isoform 3", "refseq_ac": "NP_079697", "gene_names_uniprotkb": "Acyp1; Acype", "gene_names_refseq": "1110039O14Rik; Acyp1", "protein_names_uniprotkb": "Acylphosphatase-1; 3.6.1.7; Acylphosphatase, organ-common type isozyme; Acylphosphate phosphohydrolase 1", "protein_names_refseq": "acylphosphatase 1, erythrocyte (common) type; acylphosphatase, organ-common type isozyme; acylphosphatase-1 isoform 3; acylphosphate phosphohydrolase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66204)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VG40;Q545K8;Q6P8S7", "ec_number_list": "3.6.1.7", "go_molecular_function": "GO:0003998 acylphosphatase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P56376-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBE8-1", "uniprot_id": "ALG2_MOUSE", "mass": 47405.0, "length": 415, "protein_name": "Alpha-1,3/1,6-mannosyltransferase ALG2", "gene_name": "Alg2", "organism": "Mouse", "refseq_name": "alpha-1,3/1,6-mannosyltransferase ALG2 isoform 1", "refseq_ac": "NP_064382", "gene_names_uniprotkb": "Alg2; MNCb-5081", "gene_names_refseq": "1110018A23Rik; 1300013N08Rik; ALPG2; Alg2; CDGIi; MNCb-5081", "protein_names_uniprotkb": "Alpha-1,3/1,6-mannosyltransferase ALG2; 2.4.1.132; 2.4.1.257; Asparagine-linked glycosylation protein 2 homolog; GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase; GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase", "protein_names_refseq": "GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase; GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase; alpha-1,3-mannosyltransferase ALG2; alpha-1,3/1,6-mannosyltransferase ALG2 isoform 1; alpha-1,3/1,6-mannosyltransferase ALG2; asparagine-linked glycosylation 2 (alpha-1,3-mannosyltransferase); asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase); asparagine-linked glycosylation protein 2 homolog", "tax_id": 10090, "disease": "congenital disorder of glycosylation Ii (Disease Ontology:DOID:0080561); congenital myasthenic syndrome 14 (Disease Ontology:DOID:0110669)", "pathway": " (mmu:56737); (R-MMU-446193)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17889823;21750661;24563464;26705706;30059200;33300544", "class_list": "glycogene;glycosyltransferase", "function": "ALG-2 binding to Scotin is strictly calcium dependent, indicating a role of this interaction in calcium signaling pathways, [RefSeq, PubMed]; Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the second and third mannose residues to the dolichol-linked oligosaccharide chain, to produce Man3GlcNAc(2)-PP-dolichol core oligosaccharide. Man3GlcNAc(2)-PP-dolichol is a substrate for ALG11, the following enzyme in the biosynthetic pathway. While both alpha 1,3 and alpha 1,6 linkages are possible, the sequential addition of alpha 1,3 followed by alpha 1,6 is probably the preferred route., [UniProtKB, UniProtKB]; The observation that both ALG-2 isoforms bind Mg2+ with high affinity is the most significant finding of this study, [RefSeq, PubMed]; Thus, Alg2, as a downstream mediator of Hivep3, suppresses osteogenesis, whereas it promotes chondrogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 25, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TN30;Q9CWI6;Q9JJA8", "ec_number_list": "2.4.1.132;2.4.1.257", "go_molecular_function": "GO:0000033 alpha-1,3-mannosyltransferase activity;GO:0004378 GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity;GO:0102704 GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 13365, "hit_score": 0.9, "record_id": "Q9DBE8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXB8-1", "uniprot_id": "ALPK1_MOUSE", "mass": 136134.0, "length": 1231, "protein_name": "Alpha-protein kinase 1", "gene_name": "Alpk1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Alpk1; Kiaa1527", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-protein kinase 1; 2.7.11.1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:71481); (R-MMU-445989); (R-MMU-9645460)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "21208416;21750661;25428506;30111836;30967659;34428180;35820727;35868845", "class_list": "", "function": "Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (By similarity). Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria (PubMed:30111836). ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering pro-inflammatory NF-kappa-B signaling (By similarity). May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A (By similarity). May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A (By similarity). May play a role in ciliogenesis (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZH5;Q8BLT9", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.3.2.23;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;3.4.19.12;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0048029 monosaccharide binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium;GO:0036064 ciliary basal body", "go_biological_process": "GO:0045087 innate immune response;GO:0009617 response to bacterium;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0060271 cilium assembly;GO:0002753 cytoplasmic pattern recognition receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CXB8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3UWD5-1", "uniprot_id": "AKAI1_MOUSE", "mass": 7751.0, "length": 69, "protein_name": "A-kinase anchor protein inhibitor 1", "gene_name": "Akain1", "organism": "Mouse", "refseq_name": "A-kinase anchor protein inhibitor 1", "refseq_ac": "NP_001138664", "gene_names_uniprotkb": "Akain1", "gene_names_refseq": "A330050F15Rik; Akain1", "protein_names_uniprotkb": "A-kinase anchor protein inhibitor 1", "protein_names_refseq": "A kinase (PRKA) anchor inhibitor 1; A-kinase anchor protein C18orf42 homolg; A-kinase anchor protein inhibitor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:320722)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25653177", "class_list": "", "function": "Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A-kinase anchoring protein (AKAP)-mediated subcellular localization of PKA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0031333 negative regulation of protein-containing complex assembly;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3UWD5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R157-1", "uniprot_id": "ADA18_MOUSE", "mass": 79210.0, "length": 719, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 18", "gene_name": "Adam18", "organism": "Mouse", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 18 preproprotein", "refseq_ac": "NP_034214", "gene_names_uniprotkb": "Adam18; Adam27; Dtgn3; Tmdc3", "gene_names_refseq": "Adam18; Adam27; Dtgn3; Tmdc3; tMDCIII", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 18; ADAM 18; ADAM 27; Disintegrin and metalloproteinase domain-containing protein 27; Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III; tMDC III", "protein_names_refseq": "disintegrin 3; disintegrin and metalloproteinase domain-containing protein 18 preproprotein; disintegrin and metalloproteinase domain-containing protein 18; disintegrin and metalloproteinase domain-containing protein 27; transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III", "tax_id": 10090, "disease": "", "pathway": " (mmu:13524)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;10395895;21750661;8146185", "class_list": "", "function": "Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein., [UniProtKB]; This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during early stages of spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of related ADAM genes on chromosome 8. [provided by RefSeq, May 2016]., [RefSeq]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q60621;Q80Y08", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0005178 integrin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0007283 spermatogenesis;GO:0007339 binding of sperm to zona pellucida;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9R157-1", "record_type": "protein" }, { "uniprot_canonical_ac": "J3QPP8-1", "uniprot_id": "ALKL1_MOUSE", "mass": 14246.0, "length": 127, "protein_name": "ALK and LTK ligand 1", "gene_name": "Alkal1", "organism": "Mouse", "refseq_name": "ALK and LTK ligand 1 precursor", "refseq_ac": "NP_001182661", "gene_names_uniprotkb": "Alkal1; Fam150a", "gene_names_refseq": "Alkal1; Augbeta; EG620393; Fam150a", "protein_names_uniprotkb": "ALK and LTK ligand 1; AUG-beta; Augmentor beta", "protein_names_refseq": "ALK and LTK ligand 1 precursor; AUG-beta; augmentor beta; family with sequence similarity 150, member A; protein FAM150A", "tax_id": 10090, "disease": "", "pathway": " (mmu:620393); (R-MMU-201556); (R-MMU-9842663)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "39365866", "class_list": "", "function": "Cytokine that acts as a physiological ligand for receptor tyrosine kinase LTK, leading to its activation. Monomeric ALKAL1 binds to LTK, leading to LTK homodimerization and activation. In contrast to ALKAL2, does not act as a potent physiological ligand for ALK., [UniProtKB, UniProtKB]; MerTK[+] macrophages promote melanoma progression and immunotherapy resistance through AhR-ALKAL1 activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0030971 receptor tyrosine kinase binding;GO:0030298 receptor signaling protein tyrosine kinase activator activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010976 positive regulation of neuron projection development;GO:0060612 adipose tissue development;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0032094 response to food", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "J3QPP8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08538-1", "uniprot_id": "ANGP1_MOUSE", "mass": 57519.0, "length": 498, "protein_name": "Angiopoietin-1", "gene_name": "Angpt1", "organism": "Mouse", "refseq_name": "angiopoietin-1 isoform 1 precursor", "refseq_ac": "NP_033770", "gene_names_uniprotkb": "Angpt1; Agpt", "gene_names_refseq": "1110046O21Rik; Ang-1; Ang1; Angpt1", "protein_names_uniprotkb": "Angiopoietin-1; ANG-1", "protein_names_refseq": "Angiopoietin-1; angiopoietin-1 isoform 1 precursor", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); stroke (Disease Ontology:DOID:0051061); prostate carcinoma (Disease Ontology:DOID:10286); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); hereditary angioedema (Disease Ontology:DOID:14735); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); nephrosis (Disease Ontology:DOID:2527); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial adenocarcinoma (Disease Ontology:DOID:2870); renal cell carcinoma (Disease Ontology:DOID:4450); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); in situ carcinoma (Disease Ontology:DOID:8719); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:11600); (R-MMU-210993); (R-MMU-5673001)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21606590;23041942;28179430;30084848;8980223;8980224", "class_list": "", "function": "ANG-1 is critical for regulating the number &diameter of developing vessels. It is not required for pericyte recruitment. It is dispensable in quiescent vessels but powerfully modulates the vascular response after injury., [RefSeq, PubMed]; Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme (By similarity)., [UniProtKB]; These results provide an insight into the molecular mechanisms by which Ang1 directly affects the myogenesis of striated muscle., [RefSeq, PubMed]; This gene encodes a secreted glycoprotein that belongs to the angiopoietin family of vascular growth factors. The encoded protein is a ligand in the vascular tyrosine kinase signaling pathway and regulates the formation and stabilization of blood vessels. This protein also functions in striated muscles by promoting proliferation, migration and differentiation of skeletal myoblasts and plays an essential role in the vascular response to tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 16, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6NWV7", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0030971 receptor tyrosine kinase binding;GO:0048018 receptor ligand activity;GO:0005172 vascular endothelial growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0045121 membrane raft;GO:0005902 microvillus", "go_biological_process": "GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0001701 in utero embryonic development;GO:0007162 negative regulation of cell adhesion;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O08538-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35608-1", "uniprot_id": "ANGP2_MOUSE", "mass": 56576.0, "length": 496, "protein_name": "Angiopoietin-2", "gene_name": "Angpt2", "organism": "Mouse", "refseq_name": "angiopoietin-2 precursor", "refseq_ac": "NP_031452", "gene_names_uniprotkb": "Angpt2; Agpt2", "gene_names_refseq": "Agpt2; Ang-2; Ang2; Angpt2", "protein_names_uniprotkb": "Angiopoietin-2; ANG-2", "protein_names_refseq": "angiopoietin-2 precursor", "tax_id": 10090, "disease": "hereditary lymphedema (Disease Ontology:DOID:0050580); Caroli disease (Disease Ontology:DOID:0050876); stroke (Disease Ontology:DOID:0051061); alcohol-associated liver disease (Disease Ontology:DOID:0070658); COVID-19 (Disease Ontology:DOID:0080600); portal hypertension (Disease Ontology:DOID:10762); gastric ulcer (Disease Ontology:DOID:10808); retinopathy of prematurity (Disease Ontology:DOID:13025); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); brain ischemia (Disease Ontology:DOID:2316); nephrosis (Disease Ontology:DOID:2527); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial adenocarcinoma (Disease Ontology:DOID:2870); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); adenocarcinoma (Disease Ontology:DOID:299); high grade glioma (Disease Ontology:DOID:3070); rhabdomyosarcoma (Disease Ontology:DOID:3247); ischemia (Disease Ontology:DOID:326); uremia (Disease Ontology:DOID:4676); vasculogenic impotence (Disease Ontology:DOID:4762); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); diabetic retinopathy (Disease Ontology:DOID:8947); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:11601); (R-MMU-210993)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;28179430;32908006;38808888;9204896", "class_list": "", "function": "Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (By similarity). Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1 (By similarity). In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression (By similarity). In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). Involved in the regulation of lymphangiogenesis (PubMed:28179430, PubMed:32908006)., [UniProtKB, UniProtKB, PubMed, PubMed]; Silencing ANGPT2 alleviates ulcerative colitis by regulating autophagy-mediated NLRP3 inflammasome inactivation via the mTOR signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes an endothelial cell (EC)-derived regulator of angiogenesis and ligand for endothelial-specific receptor tyrosine kinase. The encoded protein acts as an anti-apoptotic factor for stressed ECs and a proapoptotic factor for resting ECs. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 25, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3U1A1;Q9D2D2", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0048019 receptor antagonist activity;GO:0030971 receptor tyrosine kinase binding;GO:0048018 receptor ligand activity;GO:0005172 vascular endothelial growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0042995 cell projection", "go_biological_process": "GO:0001525 angiogenesis;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0001666 response to hypoxia;GO:0001974 blood vessel remodeling;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35608-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35640-1", "uniprot_id": "ANXA8_MOUSE", "mass": 36724.0, "length": 327, "protein_name": "Annexin A8", "gene_name": "Anxa8", "organism": "Mouse", "refseq_name": "annexin A8 isoform 2", "refseq_ac": "NP_001268774", "gene_names_uniprotkb": "Anxa8; Anx8", "gene_names_refseq": "Anx8; Anxa8", "protein_names_uniprotkb": "Annexin A8; Annexin VIII; Annexin-8", "protein_names_refseq": "annexin 8; annexin A8 isoform 2; annexin VIII", "tax_id": 10090, "disease": "pancreatic ductal carcinoma (Disease Ontology:DOID:3587); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (mmu:11752)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16203777;17082908;21344395;30084848;34428180;9434938", "class_list": "", "function": "ANXA8 protein is most abundant in stratified epithelia of the postnatal mouse. Its location in the suprabasal layers suggests that ANXA8 may be associated with the terminal differentiation of epithelial cells in these tissues., [RefSeq, PubMed]; Annexin A8 is involved in mouse mammary gland involution and progression of human breast cancer, [RefSeq, PubMed]; Define a distinct bone-dependent genetic program associated with terminal osteoclast differentiation and identified Anxa8 as a gene strongly induced late in osteoclast differentiation, regulating formation of the cell's characteristic actin ring., [RefSeq, PubMed]; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2N9", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031902 late endosome membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0007596 blood coagulation;GO:0007032 endosome organization;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O35640-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55112-1", "uniprot_id": "AFF2_MOUSE", "mass": 140181.0, "length": 1272, "protein_name": "AF4/FMR2 family member 2", "gene_name": "Aff2", "organism": "Mouse", "refseq_name": "AF4/FMR2 family member 2", "refseq_ac": "NP_032058", "gene_names_uniprotkb": "Aff2; Fmr2; Ox19", "gene_names_refseq": "Aff2; FMR2P; Fmr2; Ox19; Oxh", "protein_names_uniprotkb": "AF4/FMR2 family member 2; FMR2P; Protein FMR-2; Protein Ox19", "protein_names_refseq": "AF4/FMR2 family member 2; Ox19 homolog; protein FMR-2", "tax_id": 10090, "disease": "X-linked intellectual developmental disorder 109 (Disease Ontology:DOID:0080984); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:14266)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19136466;20173027;30084848;31219806;34203471;34428180;37884088;9467002", "class_list": "", "function": "CircAFF2 Promotes Neuronal Cell Injury in Intracerebral Hemorrhage by Regulating the miR-488/CLSTN3 Axis., [RefSeq, PubMed]; RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B1ATW0", "ec_number_list": "", "go_molecular_function": "GO:0002151 G-quadruplex RNA binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0007611 learning or memory;GO:0010629 negative regulation of gene expression;GO:0006355 regulation of DNA-templated transcription;GO:0050877 nervous system process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O55112-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88990-1", "uniprot_id": "ACTN3_MOUSE", "mass": 103043.0, "length": 900, "protein_name": "Alpha-actinin-3", "gene_name": "Actn3", "organism": "Mouse", "refseq_name": "alpha-actinin-3", "refseq_ac": "NP_038484", "gene_names_uniprotkb": "Actn3", "gene_names_refseq": "Actn3", "protein_names_uniprotkb": "Alpha-actinin-3; Alpha-actinin skeletal muscle isoform 3; F-actin cross-linking protein", "protein_names_refseq": "F-actin cross-linking protein; alpha-actinin skeletal muscle; alpha-actinin-3", "tax_id": 10090, "disease": "focal segmental glomerulosclerosis 1 (Disease Ontology:DOID:0111128)", "pathway": " (mmu:11474); (R-MMU-390522)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10192379;17828264;18178581;20089531;31616917;33637766;34418053;34761268;35733150;39927985", "class_list": "", "function": "Absence of the Z-disc protein alpha-actinin-3 impairs the mechanical stability of Actn3KO mouse fast-twitch muscle fibres without altering their contractile properties or twitch kinetics. Publication Status: Online-Only, [RefSeq, PubMed]; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity)., [UniProtKB]; Loss of alpha-actinin-3 confers protection from eccentric contraction damage in fast-twitch EDL muscles from aged mdx dystrophic mice by reducing pathological fibre branching., [RefSeq, PubMed]; Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q14DS8", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005925 focal adhesion;GO:0030054 cell junction;GO:0005865 striated muscle thin filament", "go_biological_process": "GO:1901078 negative regulation of relaxation of muscle;GO:0006936 muscle contraction;GO:0030036 actin cytoskeleton organization;GO:0014728 regulation of the force of skeletal muscle contraction;GO:0014732 skeletal muscle atrophy", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O88990-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11859-1", "uniprot_id": "ANGT_MOUSE", "mass": 51990.0, "length": 477, "protein_name": "Angiotensinogen", "gene_name": "Agt", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Agt; Serpina8", "gene_names_refseq": "", "protein_names_uniprotkb": "Angiotensinogen; Ang III; Ang II; Ang IV; Ang I; Angiotensin 1-10; Angiotensin 1-8; Angiotensin 2-8; Angiotensin 3-8; Angiotensin III; Angiotensin II; Angiotensin IV; Angiotensin I; Des-Asp[1]-angiotensin II; Serpin A8", "protein_names_refseq": "", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); coarctation of the aorta (Disease Ontology:DOID:0051054); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); polycystic kidney disease (Disease Ontology:DOID:0080322); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); meconium aspiration syndrome (Disease Ontology:DOID:11049); hydronephrosis (Disease Ontology:DOID:11111); IgA vasculitis (Disease Ontology:DOID:11123); pulmonary edema (Disease Ontology:DOID:11396); sciatic neuropathy (Disease Ontology:DOID:11446); prediabetes syndrome (Disease Ontology:DOID:11716); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); allergic disease (Disease Ontology:DOID:1205); otosclerosis (Disease Ontology:DOID:12185); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); dilated cardiomyopathy (Disease Ontology:DOID:12930); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); sick sinus syndrome (Disease Ontology:DOID:13884); Fabry disease (Disease Ontology:DOID:14499); diffuse scleroderma (Disease Ontology:DOID:1580); breast cancer (Disease Ontology:DOID:1612); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); hyperinsulinism (Disease Ontology:DOID:2018); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); glomerulonephritis (Disease Ontology:DOID:2921); temporal lobe epilepsy (Disease Ontology:DOID:3328); carotid artery disease (Disease Ontology:DOID:3407); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); cerebrovascular disease (Disease Ontology:DOID:6713); chronic myeloid leukemia (Disease Ontology:DOID:8552); intermediate coronary syndrome (Disease Ontology:DOID:8805); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); mitral valve prolapse (Disease Ontology:DOID:988); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11606); (R-MMU-2022377); (R-MMU-375276); (R-MMU-416476); (R-MMU-418594)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12829792;18026570;20485683;20927107;21750661;25605945;30084848;32123820;3397061;34428180;37507081", "class_list": "", "function": "Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Acts by binding to angiotensin receptors AGTR1 and AGTR2. Also binds the DEAR/FBXW7-AS1 receptor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Is a ligand for the G protein-coupled receptor MAS1 (PubMed:12829792). Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (PubMed:12829792, PubMed:18026570)., [UniProtKB, PubMed, PubMed]; Is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets., [UniProtKB, UniProtKB]; Stimulates aldosterone release., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 51, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0017080 sodium channel regulator activity;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0031702 type 1 angiotensin receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0030432 peristalsis;GO:0035106 operant conditioning;GO:0001543 ovarian follicle rupture;GO:0010701 positive regulation of norepinephrine secretion;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P11859-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19091-1", "uniprot_id": "ANDR_MOUSE", "mass": 98194.0, "length": 899, "protein_name": "Androgen receptor", "gene_name": "Ar", "organism": "Mouse", "refseq_name": "androgen receptor", "refseq_ac": "NP_038504", "gene_names_uniprotkb": "Ar; Nr3c4", "gene_names_refseq": "Ar; Tfm", "protein_names_uniprotkb": "Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4", "protein_names_refseq": "androgen receptor; dihydrotestosterone receptor; nuclear receptor subfamily 3 group C member 4; testicular feminization", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); oppositional defiant disorder (Disease Ontology:DOID:0050856); ductal carcinoma in situ (Disease Ontology:DOID:0060074); Kennedy's disease (Disease Ontology:DOID:0060161); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); partial androgen insensitivity syndrome (Disease Ontology:DOID:0080776); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); hypospadias (Disease Ontology:DOID:10892); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); prostatic hypertrophy (Disease Ontology:DOID:11132); cryptorchidism (Disease Ontology:DOID:11383); osteoporosis (Disease Ontology:DOID:11476); spinal muscular atrophy (Disease Ontology:DOID:12377); leiomyoma (Disease Ontology:DOID:127); conduct disorder (Disease Ontology:DOID:12995); endometrial cancer (Disease Ontology:DOID:1380); prostate adenocarcinoma (Disease Ontology:DOID:2526); invasive ductal carcinoma (Disease Ontology:DOID:3008); acute kidney failure (Disease Ontology:DOID:3021); androgen insensitivity syndrome (Disease Ontology:DOID:4674); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11835); (R-MMU-3371497); (R-MMU-383280); (R-MMU-4090294); (R-MMU-5625886); (R-MMU-5689880); (R-MMU-8940973)", "pathway_count": 7, "publication_count": 19, "publication_id_list": "12058073;15199138;15882980;15988012;16446156;1681426;17911242;1883336;21183079;2178222;22170608;22406838;23487765;2403358;26673324;28751364;30084848;31219806;34428180", "class_list": "", "function": "Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes a nuclear hormone receptor containing zinc finger and DNA-binding domains. The encoded protein is a key regulator of signalling by androgens, a class of steroid hormones involved in male reproductive development. The protein responds to hormone signalling by translocating to the nucleus, forming dimers, and binding to androgen response elements (AREs) in the promoters of target genes, which are subsequently transcriptionally activated. Activity of this protein is negatively regulated by nuclear receptor subfamily 0 group B member 1 (Nr0b1, also known as Dax1). Mutations in this gene result in feminized genitals and infertility in male animals. Loss of function in female animals also causes problems in reproductive development and function. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0060090 molecular adaptor activity;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0008049 male courtship behavior;GO:0046661 male sex differentiation;GO:0060406 positive regulation of penile erection;GO:0060685 regulation of prostatic bud formation;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P19091-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25962-1", "uniprot_id": "ADRB3_MOUSE", "mass": 43006.0, "length": 400, "protein_name": "Beta-3 adrenergic receptor", "gene_name": "Adrb3", "organism": "Mouse", "refseq_name": "beta-3 adrenergic receptor", "refseq_ac": "NP_038490", "gene_names_uniprotkb": "Adrb3; Adrb3r; B3bar", "gene_names_refseq": "Adrb-3; Adrb3; beta 3-AR", "protein_names_uniprotkb": "Beta-3 adrenergic receptor; Beta-3 adrenoceptor; Beta-3 adrenoreceptor", "protein_names_refseq": "Beta-3 AR; beta-3 adrenergic receptor; beta-3 adrenoceptor; beta-3 adrenoreceptor", "tax_id": 10090, "disease": "colitis (Disease Ontology:DOID:0060180); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); polycystic ovary syndrome (Disease Ontology:DOID:11612); gout (Disease Ontology:DOID:13189); endometrial cancer (Disease Ontology:DOID:1380); cystic fibrosis (Disease Ontology:DOID:1485); coronary artery disease (Disease Ontology:DOID:3393); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11556); (R-MMU-390696); (R-MMU-418555)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10207024;10455305;1336117;17032647;1718744;29661693;8389293", "class_list": "", "function": "G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent pathway, respectively (PubMed:1718744). The rank order of potency for physiological agonists is norepinephrine > epinephrine (By similarity). Involved in the regulation of thermogenesis and lipolysis in brown and white adipose tissue, after coupling to G(s) proteins and stimulation of the cAMP-PKA axis (PubMed:10207024, PubMed:1718744). Also activates lipolytic process by coupling to G(i) proteins and consequent initiation of the ERK1/2 MAP kinase cascade (PubMed:10207024, PubMed:17032647). Participates in relaxation of the blood vessels and the urinary bladder. Also mediates negative inotropic effects in cardiomyocytes through activation of an NO synthase pathway and subsequent increase in cGMP levels, possibly involving G(i/o) protein-mediated coupling (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2RS74;Q9QZ98", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051379 epinephrine binding;GO:0051380 norepinephrine binding;GO:0004939 beta-adrenergic receptor activity;GO:0015052 beta3-adrenergic receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0009409 response to cold;GO:0043410 positive regulation of MAPK cascade;GO:0050873 brown fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P25962-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29755-1", "uniprot_id": "AGTRB_MOUSE", "mass": 40950.0, "length": 359, "protein_name": "Type-1 angiotensin II receptor B", "gene_name": "Agtr1b", "organism": "Mouse", "refseq_name": "type-1 angiotensin II receptor B", "refseq_ac": "NP_780295", "gene_names_uniprotkb": "Agtr1b", "gene_names_refseq": "AT1B; AT2R1B; Agtr-1b; Agtr1b; Angtr-1b", "protein_names_uniprotkb": "Type-1 angiotensin II receptor B; AT1 receptor B; AT3; Angiotensin II type-1 receptor B", "protein_names_refseq": "AT1 receptor B; AT3; angiotensin II type-1 receptor B; angiotensin II type-1B receptor; type-1 angiotensin II receptor B; type-1B angiotensin II receptor", "tax_id": 10090, "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); COVID-19 (Disease Ontology:DOID:0080600); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); sarcoidosis (Disease Ontology:DOID:11335); Friedreich ataxia (Disease Ontology:DOID:12705); Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); renovascular hypertension (Disease Ontology:DOID:1591); breast cancer (Disease Ontology:DOID:1612); IgA glomerulonephritis (Disease Ontology:DOID:2986); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); renal cell carcinoma (Disease Ontology:DOID:4450); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); cerebrovascular disease (Disease Ontology:DOID:6713); chronic kidney disease (Disease Ontology:DOID:784); intermediate coronary syndrome (Disease Ontology:DOID:8805); vesicoureteral reflux (Disease Ontology:DOID:9620)", "pathway": " (mmu:11608)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1497638;1599461;31886721;33781840;34069164;39192727", "class_list": "", "function": "AT1 and AT2 Receptor Knockout Changed Osteonectin and Bone Density in Mice in Periodontal Inflammation Experimental Model. Publication Status: Online-Only, [RefSeq, PubMed]; AT1Rb and total AT1R expression levels are much lower in parenchymal arterioles compared with pial arteries and that parenchymal arterioles are less sensitive to the vasoconstrictive effects of the endogenous AT1R ligand angiotensin II (ANG II), [RefSeq, PubMed]; AT1b receptors contribute to regional disparities in angiotensin II mediated aortic remodelling in mice., [RefSeq, PubMed]; Angiotensin receptors in the kidney and vasculature in hypertension and kidney disease. Review article, [RefSeq, PubMed]; Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031711 bradykinin receptor binding;GO:0001596 angiotensin type I receptor activity;GO:0004945 angiotensin type II receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0045777 positive regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P29755-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54923-1", "uniprot_id": "ADPRH_MOUSE", "mass": 40068.0, "length": 362, "protein_name": "ADP-ribosylhydrolase ARH1", "gene_name": "Adprh", "organism": "Mouse", "refseq_name": "ADP-ribosylarginine hydrolase", "refseq_ac": "NP_031440", "gene_names_uniprotkb": "Adprh; Arh1", "gene_names_refseq": "Adprh; Arh1", "protein_names_uniprotkb": "ADP-ribosylhydrolase ARH1; 3.2.2.19; ADP-ribose-L-arginine cleaving enzyme; ADP-ribosylarginine hydrolase; [Protein ADP-ribosylarginine] hydrolase", "protein_names_refseq": "ADP-ribose-L-arginine cleaving enzyme; ADP-ribosylarginine hydrolase; [Protein ADP-ribosylarginine] hydrolase", "tax_id": 10090, "disease": "", "pathway": " (mmu:11544)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15893437;17526733;21697277;30500844;34428180;8349667", "class_list": "", "function": "ADP-ribosylarginine hydrolase promoter activity pattern and involvement of Sp transcription factors are consistent with prior observations of widespread hydrolase expression in mammalian tissues., [RefSeq, PubMed]; ARH1(-/-) and ARH1(+/-) mice spontaneously develop lymphomas, adenocarcinomas, & metastases more frequently than wild-type. Proper control of protein ADP-ribosylation levels affected by ARH1 is essential for cancer suppression., [RefSeq, PubMed]; Cholera toxin-catalyzed ADP-ribosylation of cell proteins can be counteracted by ADPRH, which could function as a modifier gene in disease., [RefSeq, PubMed]; Intestinal loops derived from female ADP-ribosylarginine hydrolase knockout (ARH1-KO) mice when injected with cholera toxin showed increased fluid accumulation compared to male ARH1-KO mice. Publication Status: Online-Only, [RefSeq, PubMed]; Specifically acts as an arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.2.2.19;3.5.1.-;3.2.2.-;3.2.1.143;3.1.1.106", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003875 ADP-ribosylarginine hydrolase activity;GO:0030955 potassium ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0036211 protein modification process;GO:0051725 protein de-ADP-ribosylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P54923-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56213-1", "uniprot_id": "ALR_MOUSE", "mass": 22877.0, "length": 198, "protein_name": "FAD-linked sulfhydryl oxidase ALR", "gene_name": "Gfer", "organism": "Mouse", "refseq_name": "FAD-linked sulfhydryl oxidase ALR isoform 1", "refseq_ac": "NP_075527", "gene_names_uniprotkb": "Gfer; Alr; MNCb-0663", "gene_names_refseq": "Alr; ERV1; Gfer", "protein_names_uniprotkb": "FAD-linked sulfhydryl oxidase ALR; 1.8.3.2; Augmenter of liver regeneration", "protein_names_refseq": "FAD-linked sulfhydryl oxidase ALR isoform 1; FAD-linked sulfhydryl oxidase ALR; augmenter of liver regeneration; growth factor, erv1-like (augmenter of liver regeneration)", "tax_id": 10090, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); autosomal recessive centronuclear myopathy (Disease Ontology:DOID:0111216); kidney failure (Disease Ontology:DOID:1074); cryptorchidism (Disease Ontology:DOID:11383); acute kidney failure (Disease Ontology:DOID:3021); ureteral obstruction (Disease Ontology:DOID:5199); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (mmu:11692)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12089204;16937489;20147447;21750661;32031683;33835027;36434180;37666068;8900538", "class_list": "", "function": "Augmenter of liver regeneration regulates cellular iron homeostasis by modulating mitochondrial transport of ATP-binding cassette B8. Publication Status: Online-Only, [RefSeq, PubMed]; FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen (By similarity)., [UniProtKB, UniProtKB]; Growth factor erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells, [RefSeq, PubMed]; Hepatic Deficiency of Augmenter of Liver Regeneration Predisposes to Nonalcoholic Steatohepatitis and Fibrosis., [RefSeq, PubMed]; Imbalance in ALR ubiquitination accelerates the progression of nonalcoholic steatohepatitis to hepatocellular carcinoma., [RefSeq, PubMed]; Review of the molecular biology of ALR [review] Review article, [RefSeq, PubMed]; Studies demonstrated a specific accumulation of full-length mouse Alrp during the early stages of spermatogenesis; the highest levels of Alrp were found in spermatogonia and primary spermatocytes, [RefSeq, PubMed]; TMPRSS11D/ALR-mediated ER stress regulates the function of myeloid-derived suppressor cells in the cervical cancer microenvironment., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIF8;Q9JJE6", "ec_number_list": "1.8.3.2", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0008083 growth factor activity;GO:0015035 protein-disulfide reductase activity;GO:0016971 flavin-dependent sulfhydryl oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0001889 liver development;GO:0043066 negative regulation of apoptotic process;GO:0045953 negative regulation of natural killer cell mediated cytotoxicity;GO:0097421 liver regeneration;GO:2000573 positive regulation of DNA biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P56213-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61164-1", "uniprot_id": "ACTZ_MOUSE", "mass": 42614.0, "length": 376, "protein_name": "Alpha-centractin", "gene_name": "Actr1a", "organism": "Mouse", "refseq_name": "alpha-centractin isoform 1", "refseq_ac": "NP_058556", "gene_names_uniprotkb": "Actr1a; Ctrn1", "gene_names_refseq": "Actr1a; Arp1; actin-RPV; alpha-Arp1", "protein_names_uniprotkb": "Alpha-centractin; ARP1; Actin-RPV; Centractin; Centrosome-associated actin homolog", "protein_names_refseq": "ARP1 actin-related protein 1 homolog A, centractin alpha; actin-related protein 1 alpha; alpha-centractin isoform 1; alpha-centractin; centrosome-associated actin homolog", "tax_id": 10090, "disease": "Down syndrome (Disease Ontology:DOID:14250); colon cancer (Disease Ontology:DOID:219)", "pathway": " (mmu:54130); (R-MMU-2132295); (R-MMU-2565942); (R-MMU-3371497); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-6807878); (R-MMU-6811436); (R-MMU-8854518)", "pathway_count": 12, "publication_count": 10, "publication_id_list": "20603325;21750661;22872234;26740625;31219806;33300544;34428180;36210013;37828378;9200982", "class_list": "", "function": "Beta-III spectrin mutation L253P interferes with binding to Arp1 and protein trafficking from the Golgi., [RefSeq, PubMed]; Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P42024;Q3TJF9", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005938 cell cortex;GO:0043209 myelin sheath;GO:0002177 manchette", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P61164-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62737-1", "uniprot_id": "ACTA_MOUSE", "mass": 42009.0, "length": 377, "protein_name": "Actin, aortic smooth muscle", "gene_name": "Acta2", "organism": "Mouse", "refseq_name": "actin, aortic smooth muscle", "refseq_ac": "NP_031418", "gene_names_uniprotkb": "Acta2; Actsa; Actvs", "gene_names_refseq": "0610041G09Rik; Acta2; Actvs; SMAalpha; SMalphaA; a-SMA; alphaSMA", "protein_names_uniprotkb": "Actin, aortic smooth muscle; 3.6.4.-; Alpha-actin-2", "protein_names_refseq": "actin, alpha, vascular smooth muscle; actin, aortic smooth muscle; alpha-actin-2", "tax_id": 10090, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); Baraitser-Winter syndrome 1 (Disease Ontology:DOID:0081112); autosomal dominant nonsyndromic deafness 20 (Disease Ontology:DOID:0110550); intestinal atresia (Disease Ontology:DOID:10486); Moyamoya disease (Disease Ontology:DOID:13099); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); lymphedema (Disease Ontology:DOID:4977)", "pathway": " (mmu:11475); (R-MMU-445355); (R-MMU-9764561); (R-MMU-9913351); (R-MMU-9958825)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12209622;21679490;21750661;22645316;23911929;2398068;28179430;29187734;3194212;33300544;36173861;6725286", "class_list": "", "function": "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., [UniProtKB]; The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in smooth muscle. [provided by RefSeq, Feb 2021]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P03996;P04108", "ec_number_list": "3.6.4.13;3.6.4.10;2.3.2.31;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.2;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;2.3.2.26;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0031514 motile cilium", "go_biological_process": "GO:2000491 positive regulation of hepatic stellate cell activation;GO:0006936 muscle contraction;GO:0010628 positive regulation of gene expression;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0008217 regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P62737-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97802-1", "uniprot_id": "ANG3_MOUSE", "mass": 16696.0, "length": 145, "protein_name": "Angiogenin-3", "gene_name": "Ang3", "organism": "Mouse", "refseq_name": "angiogenin-3 precursor", "refseq_ac": "NP_001116866", "gene_names_uniprotkb": "Ang3; Angl", "gene_names_refseq": "Ang3; Angl; Ef-5; Rnase5c", "protein_names_uniprotkb": "Angiogenin-3; 3.1.27.-; Angiogenin-related protein 2; EF-5", "protein_names_refseq": "angiogenin related protein 2; angiogenin-3 precursor; angiogenin-3", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); ductal carcinoma in situ (Disease Ontology:DOID:0060074); amyotrophic lateral sclerosis type 9 (Disease Ontology:DOID:0060200); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); eosinophilic esophagitis (Disease Ontology:DOID:13922); Parkinson's disease (Disease Ontology:DOID:14330); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); cerebral infarction (Disease Ontology:DOID:3526); trophoblastic neoplasm (Disease Ontology:DOID:4085); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); myocardial infarction (Disease Ontology:DOID:5844); rheumatoid arthritis (Disease Ontology:DOID:7148); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:11730)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11437607;23170778;9032278", "class_list": "", "function": "Has low ribonuclease activity (in vitro)., [UniProtKB, PubMed, PubMed]; The crystal structures of two more murine Ang paralogues, mAng-2 and mAng-3 reveal homology with the human homologues., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0032055 negative regulation of translation in response to stress;GO:0001525 angiogenesis;GO:0001878 response to yeast;GO:0007165 signal transduction;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97802-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01337-1", "uniprot_id": "ADA2C_MOUSE", "mass": 49906.0, "length": 458, "protein_name": "Alpha-2C adrenergic receptor", "gene_name": "Adra2c", "organism": "Mouse", "refseq_name": "alpha-2C adrenergic receptor", "refseq_ac": "NP_031444", "gene_names_uniprotkb": "Adra2c", "gene_names_refseq": "Adra-2c; Adra2c; [a]2C; alpha2-C4; alpha2C", "protein_names_uniprotkb": "Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenoceptor; Alpha-2C adrenoreceptor; Alpha-2CAR", "protein_names_refseq": "alpha-2 adrenergic receptor subtype C4; alpha-2C adrenergic receptor; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; alpha-2CAR; subtype alpha2-C4", "tax_id": 10090, "disease": "congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:11553); (R-MMU-390696); (R-MMU-392023); (R-MMU-400042); (R-MMU-418594); (R-MMU-418597); (R-MMU-5683826)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "10647009;1353249;30084848;8387367", "class_list": "", "function": "Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (By similarity). ADRA2A and ADRA2C mediates the presynaptic feedback inhibition of neurotransmitter release from noradrenergic nerve terminals in sympathetic and central nervous systems. ADRA2A inhibits transmitter release at high stimulation frequencies, whereas ADRA2C modulates neurotransmission at lower levels of nerve activity (PubMed:10647009)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0004938 alpha2-adrenergic receptor activity;GO:0031694 alpha-2A adrenergic receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0045666 positive regulation of neuron differentiation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0007565 female pregnancy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q01337-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TY86-1", "uniprot_id": "AIFM3_MOUSE", "mass": 66792.0, "length": 605, "protein_name": "Apoptosis-inducing factor 3", "gene_name": "Aifm3", "organism": "Mouse", "refseq_name": "apoptosis-inducing factor 3 isoform 1", "refseq_ac": "NP_001277999", "gene_names_uniprotkb": "Aifm3; Aifl", "gene_names_refseq": "2810401C16Rik; Aifl; Aifm3", "protein_names_uniprotkb": "Apoptosis-inducing factor 3; 1.-.-.-; Apoptosis-inducing factor-like protein", "protein_names_refseq": "apoptosis-inducing factor 3 isoform 1; apoptosis-inducing factor 3; apoptosis-inducing factor like; apoptosis-inducing factor-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:72168)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19280713", "class_list": "", "function": "AIF-deficient mice display similar rates of H2O2 release and protein carbonyl modifications in brain mitochondria compared to WT controls, [RefSeq, PubMed]; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBD6;Q4VAA4;Q8BWV0", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0016651 oxidoreductase activity, acting on NAD(P)H", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0097194 execution phase of apoptosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3TY86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TYQ9-1", "uniprot_id": "AOXD_MOUSE", "mass": 148279.0, "length": 1336, "protein_name": "Aldehyde oxidase 4", "gene_name": "Aox4", "organism": "Mouse", "refseq_name": "aldehyde oxidase 4", "refseq_ac": "NP_076120", "gene_names_uniprotkb": "Aox4; Aoh2", "gene_names_refseq": "2310003G12Rik; Aoh2; Aox4", "protein_names_uniprotkb": "Aldehyde oxidase 4; 1.17.3.-; 1.2.3.1; Aldehyde oxidase homolog 2; Azaheterocycle hydroxylase 4; Retinal oxidase", "protein_names_refseq": "aldehyde oxidase 4; aldehyde oxidase homolog 2; aldehyde oxidase structural homolog 2; azaheterocycle hydroxylase 4; retinal oxidase", "tax_id": 10090, "disease": "xanthinuria (Disease Ontology:DOID:0060236)", "pathway": " (mmu:71872)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11562361;18981221;23263164;25287365;27456060", "class_list": "", "function": "Aldehyde oxidase able to catalyze the oxidation of retinaldehyde into retinoate. Is responsible for the major all-trans-retinaldehyde-metabolizing activity in the Harderian gland, and contributes a significant amount of the same activity in the skin. Is devoid of pyridoxal-oxidizing activity, in contrast to the other aldehyde oxidases. Acts as a negative modulator of the epidermal trophism. May be able to oxidize a wide variety of aldehydes into their corresponding carboxylates and to hydroxylate azaheterocycles., [UniProtKB, PubMed]; Although mAOX2 and mAOX3 are very similar to each other, we propose the following pairs of overlapping substrate specificities: mAOX2/mAOX4 and mAOX3/mAXO1., [RefSeq, PubMed]; Data indicate a significant role of AOH2 in the local synthesis and biodisposition of endogenous retinoids in the Harderian gland and skin, [RefSeq, PubMed]; Deletion of the Aox4 gene causes perturbations in diurnal rhythms, fat deposition and locomotor activity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VI17", "ec_number_list": "1.17.3.-;1.2.3.1", "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0005506 iron ion binding;GO:0009055 electron transfer activity;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006805 xenobiotic metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3TYQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3URE1-1", "uniprot_id": "ACSF3_MOUSE", "mass": 65077.0, "length": 583, "protein_name": "Malonate--CoA ligase ACSF3, mitochondrial", "gene_name": "Acsf3", "organism": "Mouse", "refseq_name": "malonate--CoA ligase ACSF3, mitochondrial precursor", "refseq_ac": "NP_659181", "gene_names_uniprotkb": "Acsf3", "gene_names_refseq": "Acsf3", "protein_names_uniprotkb": "Malonate--CoA ligase ACSF3, mitochondrial; 6.2.1.76; Acyl-CoA synthetase family member 3", "protein_names_refseq": "acyl-CoA synthetase family member 3, mitochondrial; malonate--CoA ligase ACSF3, mitochondrial precursor; malonate--CoA ligase ACSF3, mitochondrial", "tax_id": 10090, "disease": "combined malonic and methylmalonic acidemia (Disease Ontology:DOID:0111263)", "pathway": " (mmu:257633); (R-MMU-75876)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;25428506;28479296;34428180", "class_list": "", "function": "An essential role for ACSF3 in dictating the metabolic fate of mitochondrial malonate and malonyl-CoA in mammalian metabolism, [RefSeq, PubMed]; Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q78IW2;Q8VC75", "ec_number_list": "6.2.1.3;6.2.1.-;6.2.1.15;6.2.1.7;6.2.1.24;6.2.1.76", "go_molecular_function": "GO:0005524 ATP binding;GO:0031957 very long-chain fatty acid-CoA ligase activity;GO:0016405 CoA-ligase activity;GO:0090409 malonyl-CoA synthetase activity;GO:0016874 ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005737 cytoplasm", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0090410 malonate catabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3URE1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V132-1", "uniprot_id": "ADT4_MOUSE", "mass": 35258.0, "length": 320, "protein_name": "ADP/ATP translocase 4", "gene_name": "Slc25a31", "organism": "Mouse", "refseq_name": "ADP/ATP translocase 4", "refseq_ac": "NP_848473", "gene_names_uniprotkb": "Slc25a31; Aac4; Ant4; Sfec", "gene_names_refseq": "1700034J06Rik; Ant4; Sfec; Slc25a31", "protein_names_uniprotkb": "ADP/ATP translocase 4; ADP,ATP carrier protein 4; ANT 4; Adenine nucleotide translocator 4; Solute carrier family 25 member 31; Sperm flagellar energy carrier protein", "protein_names_refseq": "ADP,ATP carrier protein 4; ADP/ATP translocase 4; ANT 4; adenine nucleotide translocase 4; adenine nucleotide translocator 4; solute carrier family 25 member 31; sperm flagellar energy carrier protein", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome 12b (Disease Ontology:DOID:0080335); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2 (Disease Ontology:DOID:0111517); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:73333)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16051982;17137571;17681941;18667754;19556438;31489369;34428180;35820727;38808891", "class_list": "", "function": "ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). Specifically required during spermatogenesis, probably to mediate ADP:ATP exchange in spermatocytes (PubMed:17137571, PubMed:17681941, PubMed:19556438). Large ATP supplies from mitochondria may be critical for normal progression of spermatogenesis during early stages of meiotic prophase I, including DNA double-strand break repair and chromosomal synapsis (PubMed:19556438). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:31489369). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A31/ANT4 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Among nucleotides, may also exchange ADP for dATP and dADP (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31489369). It is however unclear if SLC25A31/ANT4 constitutes a pore-forming component of mPTP or regulates it (PubMed:31489369)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Adenine nucleotide translocase 4 deficiency leads to early meiotic arrest of murine male germ cells., [RefSeq, PubMed]; Adenine nucleotide translocase 4 is essential for spermatogenesis, [RefSeq, PubMed]; The essential role of adenine nucleotide translocase 4 on male reproductive function in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80W28", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0005471 ATP:ADP antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0005757 mitochondrial permeability transition pore complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0046902 regulation of mitochondrial membrane permeability;GO:0007141 male meiosis I;GO:0140021 mitochondrial ADP transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3V132-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F259-1", "uniprot_id": "AN13B_MOUSE", "mass": 70374.0, "length": 626, "protein_name": "Ankyrin repeat domain-containing protein 13B", "gene_name": "Ankrd13b", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 13B isoform 3", "refseq_ac": "NP_766533", "gene_names_uniprotkb": "Ankrd13b", "gene_names_refseq": "Ankrd13b; B930093C12Rik", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 13B", "protein_names_refseq": "ankyrin repeat domain-containing protein 13B isoform 3; ankyrin repeat domain-containing protein 13B", "tax_id": 10090, "disease": "", "pathway": " (mmu:268445)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;26495903", "class_list": "", "function": "Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EKW8;Q6IR40", "ec_number_list": "", "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005770 late endosome", "go_biological_process": "GO:0002091 negative regulation of receptor internalization;GO:0048259 regulation of receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5F259-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SGK3-1", "uniprot_id": "AOXB_MOUSE", "mass": 147913.0, "length": 1345, "protein_name": "Aldehyde oxidase 2", "gene_name": "Aox2", "organism": "Mouse", "refseq_name": "aldehyde oxidase 2", "refseq_ac": "NP_001008419", "gene_names_uniprotkb": "Aox2; Aoh3; Aox3l1", "gene_names_refseq": "Aoh3; Aox2; Aox3l1", "protein_names_uniprotkb": "Aldehyde oxidase 2; 1.17.3.-; 1.2.3.1; Aldehyde oxidase homolog 3; Azaheterocycle hydroxylase 2", "protein_names_refseq": "aldehyde oxidase 2; aldehyde oxidase 3-like 1; aldehyde oxidase homolog 3; aldehyde oxidase-like protein 3; azaheterocycle hydroxylase 2", "tax_id": 10090, "disease": "xanthinuria (Disease Ontology:DOID:0060236)", "pathway": " (mmu:213043)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15383531;23263164;25287365;34428180", "class_list": "", "function": "Although mAOX2 and mAOX3 are very similar to each other, we propose the following pairs of overlapping substrate specificities: mAOX2/mAOX4 and mAOX3/mAXO1., [RefSeq, PubMed]; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as phthalazine, as well as aldehydes, such as benzaldehyde and retinal. Cannot use hypoxanthine as substrate., [UniProtKB, PubMed]; Selectively expressed in Bowman's glands of the olfactory mucosa, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EKC6", "ec_number_list": "1.17.3.-;1.2.3.1", "go_molecular_function": "GO:0005506 iron ion binding;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0004031 aldehyde oxidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006805 xenobiotic metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5SGK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61578-1", "uniprot_id": "ADRO_MOUSE", "mass": 54202.0, "length": 494, "protein_name": "NADPH:adrenodoxin oxidoreductase, mitochondrial", "gene_name": "Fdxr", "organism": "Mouse", "refseq_name": "NADPH:adrenodoxin oxidoreductase, mitochondrial isoform 1", "refseq_ac": "NP_032023", "gene_names_uniprotkb": "Fdxr", "gene_names_refseq": "AR; Fdxr", "protein_names_uniprotkb": "NADPH:adrenodoxin oxidoreductase, mitochondrial; 1.18.1.6; AR; Adrenodoxin reductase; Ferredoxin reductase; Ferredoxin--NADP(+) reductase", "protein_names_refseq": "NADPH:adrenodoxin oxidoreductase, mitochondrial isoform 1; NADPH:adrenodoxin oxidoreductase, mitochondrial; adrenodoxin reductase; ferredoxin--NADP(+) reductase", "tax_id": 10090, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584); Parkinson's disease (Disease Ontology:DOID:14330); auditory system disease (Disease Ontology:DOID:2742); optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (mmu:14149); (R-MMU-196108); (R-MMU-211976); (R-MMU-2395516)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "25428506;29040572;34428180;36718792;7495857", "class_list": "", "function": "HnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice., [RefSeq, PubMed]; Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver (By similarity). Also acts as a ferredoxin--NADP(+) reductase essential for coenzyme Q biosynthesis: together with FDX2, transfers the electrons required for the hydroxylation reaction performed by COQ6 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.18.1.6;1.14.15.6", "go_molecular_function": "GO:0004324 ferredoxin-NADP+ reductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0006694 steroid biosynthetic process;GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61578-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q640P2-1", "uniprot_id": "ANGL1_MOUSE", "mass": 56323.0, "length": 490, "protein_name": "Angiopoietin-related protein 1", "gene_name": "Angptl1", "organism": "Mouse", "refseq_name": "angiopoietin-related protein 1 precursor", "refseq_ac": "NP_082609", "gene_names_uniprotkb": "Angptl1", "gene_names_refseq": "2810039D03Rik; ANG3; ANGPT3; ANGY; ARP1; Angptl1", "protein_names_uniprotkb": "Angiopoietin-related protein 1; Angiopoietin-like protein 1", "protein_names_refseq": "angiopoietin-like protein 1; angiopoietin-related protein 1 precursor; angiopoietin-related protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72713)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17676644;17919782;31219806;33910546;34428180;35475476", "class_list": "", "function": "ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer., [RefSeq, PubMed]; Angiopoietin-like protein 1 expression is related to intermuscular connective tissue and cartilage development, [RefSeq, PubMed]; Influence of Angptl1 on osteoclast formation and osteoblastic phenotype in mouse cells. Publication Status: Online-Only, [RefSeq, PubMed]; We conclude that angptl1 may have a beneficial role in the preservation of vascular integrity following focal cerebral ischemia., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQL1;Q9CZ81", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q640P2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64326-1", "uniprot_id": "ACTHR_MOUSE", "mass": 33982.0, "length": 296, "protein_name": "Adrenocorticotropic hormone receptor", "gene_name": "Mc2r", "organism": "Mouse", "refseq_name": "adrenocorticotropic hormone receptor", "refseq_ac": "NP_001258645", "gene_names_uniprotkb": "Mc2r; Acthr", "gene_names_refseq": "ACTH-R; ACTHR; MC2-R; Mc2r", "protein_names_uniprotkb": "Adrenocorticotropic hormone receptor; ACTH receptor; ACTH-R; Adrenocorticotropin receptor; MC2-R; Melanocortin receptor 2", "protein_names_refseq": "ACTH receptor; adrenocorticotropic hormone receptor; adrenocorticotropin receptor; melanocortin receptor 2", "tax_id": 10090, "disease": "West syndrome (Disease Ontology:DOID:0050562); glucocorticoid deficiency 1 (Disease Ontology:DOID:0080621); toxic shock syndrome (Disease Ontology:DOID:14115)", "pathway": " (mmu:17200); (R-MMU-375276); (R-MMU-418555)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "16109736;17170082;17989225;28146118;7626130;7875603", "class_list": "", "function": "G protein-coupled receptor for corticotropin/ACTH, primarily expressed in adrenal cortex where it plays a key role in the regulation of adrenocortical function (By similarity). Upon activation, couples to G(s) protein, stimulating adenylate cyclase and activating the cAMP-dependent signaling pathway, the MAPK cascade as well as the PKA pathway, leading to steroidogenic factor 1/NR5A1-mediated transcriptional activation (PubMed:17989225). Activation by ACTH facilitates the release of adrenal glucocorticoids, including cortisol and corticosterone (By similarity). In addition, MC2R is required for fetal and neonatal adrenal gland development (PubMed:16109736)., [UniProtKB, UniProtKB, PubMed, PubMed]; JDP2 acts as a novel transcriptional activator of the mouse Mc2r gene, suggesting that JDP2 may have physiological functions as a novel player in MC2R-mediated steroidogenesis as well as cell signaling in adrenal glands. Publication Status: Online-Only, [RefSeq, PubMed]; MC2-R gene is regulated both transcriptionally and post-transcriptionally during adipogenesis, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0046872 metal ion binding;GO:0004978 corticotropin receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0031948 positive regulation of glucocorticoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q64326-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NZB1-1", "uniprot_id": "ANM6_MOUSE", "mass": 41866.0, "length": 378, "protein_name": "Protein arginine N-methyltransferase 6", "gene_name": "Prmt6", "organism": "Mouse", "refseq_name": "protein arginine N-methyltransferase 6", "refseq_ac": "NP_849222", "gene_names_uniprotkb": "Prmt6; Hrmt1l6", "gene_names_refseq": "Hrmt1l6; Prmt6", "protein_names_uniprotkb": "Protein arginine N-methyltransferase 6; 2.1.1.319; Histone-arginine N-methyltransferase PRMT6", "protein_names_refseq": "HMT1 hnRNP methyltransferase-like 6; histone-arginine N-methyltransferase PRMT6; protein arginine N-methyltransferase 6", "tax_id": 10090, "disease": "cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:99890); (R-MMU-3214858); (R-MMU-8936459)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "22904064;24570487;26070566;31219806;38323918;38402915;39120025;39134684", "class_list": "", "function": "Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:22904064, PubMed:26070566). Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (By similarity). Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (By similarity). H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (By similarity). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (PubMed:22904064). Repression of TP53 blocks cellular senescence (PubMed:22904064). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively) (By similarity). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity (By similarity). Methylates HMGA1 (By similarity). Regulates alternative splicing events (By similarity). Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1 (By similarity). Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator (PubMed:24570487). Methylates GPS2, protecting GPS2 from ubiquitination and degradation (PubMed:26070566). Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; PRMT6 Epigenetically Drives Metabolic Switch from Fatty Acid Oxidation toward Glycolysis and Promotes Osteoclast Differentiation During Osteoporosis., [RefSeq, PubMed]; PRMT6 deficiency or inhibition alleviates neuropathic pain by decreasing glycolysis and inflammation in microglia., [RefSeq, PubMed]; PRMT6-FOXO3A ATTENUATES APOPTOSIS BY UPREGULATING PARKIN EXPRESSION IN INTESTINAL ISCHEMIA-REPERFUSION INJURY., [RefSeq, PubMed]; The PRMT6/STAT1/ACSL1 axis promotes ferroptosis in diabetic nephropathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TA42;Q8BN52;Q8BSC2;Q8R5D7", "ec_number_list": "2.1.1.319;3.5.1.-;3.5.1.98", "go_molecular_function": "GO:0003682 chromatin binding;GO:0016274 protein-arginine N-methyltransferase activity;GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity;GO:0042054 histone methyltransferase activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6NZB1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P1H6-1", "uniprot_id": "ANKL2_MOUSE", "mass": 106198.0, "length": 964, "protein_name": "Ankyrin repeat and LEM domain-containing protein 2", "gene_name": "Ankle2", "organism": "Mouse", "refseq_name": "ankyrin repeat and LEM domain-containing protein 2 isoform 1", "refseq_ac": "NP_001240743", "gene_names_uniprotkb": "Ankle2; D5Ertd585e; Kiaa0692; Lem4", "gene_names_refseq": "1110001J12Rik; Ankle2; D5Ertd585e", "protein_names_uniprotkb": "Ankyrin repeat and LEM domain-containing protein 2; LEM domain-containing protein 4", "protein_names_refseq": "LEM domain-containing protein 4; ankyrin repeat and LEM domain-containing protein 2 isoform 1; ankyrin repeat and LEM domain-containing protein 2", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 16 (Disease Ontology:DOID:0070289); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (mmu:71782); (R-MMU-2995383); (R-MMU-9013404); (R-MMU-9013408)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "21183079;25343476;28528544;30779550;31219806;34203471;34428180", "class_list": "", "function": "Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. May regulate nuclear localization of VRK1 in non-dividing cells. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development., [UniProtKB, UniProtKB]; Restoring the expression of one Zfp335 target, Ankle2, partially rescues T cell maturation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQF6;Q3UY52;Q3V1X7;Q6ZQ67;Q8BRM7;Q9CTK6", "ec_number_list": "", "go_molecular_function": "GO:0004860 protein kinase inhibitor activity;GO:0051721 protein phosphatase 2A binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0051301 cell division;GO:0007417 central nervous system development;GO:0007084 mitotic nuclear membrane reassembly;GO:0042326 negative regulation of phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6P1H6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PDY2-1", "uniprot_id": "AEDO_MOUSE", "mass": 28372.0, "length": 256, "protein_name": "2-aminoethanethiol dioxygenase", "gene_name": "Ado", "organism": "Mouse", "refseq_name": "2-aminoethanethiol dioxygenase", "refseq_ac": "NP_001005419", "gene_names_uniprotkb": "Ado; Gm237", "gene_names_refseq": "Ado; Gm237", "protein_names_uniprotkb": "2-aminoethanethiol dioxygenase; 1.13.11.19; Cysteamine dioxygenase", "protein_names_refseq": "2-aminoethanethiol (cysteamine) dioxygenase; 2-aminoethanethiol dioxygenase; cysteamine dioxygenase", "tax_id": 10090, "disease": "", "pathway": " (mmu:211488); (R-MMU-1614558)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17581819;21750661;32510930;32601061;34105348;34762398", "class_list": "", "function": "Characterization of the nonheme iron center of cysteamine dioxygenase and its interaction with substrates., [RefSeq, PubMed]; Cysteamine (2-aminoethanethiol) dioxygenase (ADO)is encoded by the gene Gm237 and belongs to the DUF1637 protein family., [RefSeq, PubMed]; Plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as a cosubstrate (PubMed:17581819, PubMed:32601061). Catalyzes the oxidation of cysteamine (2-aminoethanethiol) to hypotaurine (PubMed:17581819, PubMed:32601061). Catalyzes the oxidation of the regulator of G protein signaling 5 (RGS5) (PubMed:32601061). Also oxidizes proteins RGS4 and interleukin-32 (IL32) (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Spectroscopic Investigation of Cysteamine Dioxygenase., [RefSeq, PubMed]; The Crystal Structure of Cysteamine Dioxygenase Reveals the Origin of the Large Substrate Scope of This Vital Mammalian Enzyme., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2E1", "ec_number_list": "1.13.11.19", "go_molecular_function": "GO:0005506 iron ion binding;GO:0047800 cysteamine dioxygenase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6PDY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80T32-1", "uniprot_id": "AGRD1_MOUSE", "mass": 99277.0, "length": 903, "protein_name": "Adhesion G protein-coupled receptor D1", "gene_name": "Adgrd1", "organism": "Mouse", "refseq_name": "adhesion G-protein coupled receptor D1 isoform 3 precursor", "refseq_ac": "NP_001074811", "gene_names_uniprotkb": "Adgrd1; Gpr133", "gene_names_refseq": "Adgrd1; E230012M21Rik; Gpr133", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor D1; G protein-coupled receptor 133", "protein_names_refseq": "G protein coupled receptor Gpr133; G-protein coupled receptor PGR25; adhesion G-protein coupled receptor D1 isoform 3 precursor; probable G-protein coupled receptor 133", "tax_id": 10090, "disease": "", "pathway": " (mmu:243277)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12679517;22025619;33623007;34428180;39884271", "class_list": "", "function": "Adhesion G protein-coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens (PubMed:39884271). Also activated by methenolone drug (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). ADGRD1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (By similarity). Acts as a 5alpha-DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength (PubMed:39884271)., [UniProtKB, UniProtKB, PubMed]; Cell adhesion receptor GPR133 couples to Gs protein, [RefSeq, PubMed]; Control of oviductal fluid flow by the G-protein coupled receptor Adgrd1 is essential for murine embryo transit. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "B2RXC3;Q8BW80", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0014819 regulation of skeletal muscle contraction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q80T32-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UU1-1", "uniprot_id": "ANKZ1_MOUSE", "mass": 82976.0, "length": 748, "protein_name": "tRNA endonuclease ANKZF1", "gene_name": "Ankzf1", "organism": "Mouse", "refseq_name": "tRNA endonuclease ANKZF1 isoform 2", "refseq_ac": "NP_001254549", "gene_names_uniprotkb": "Ankzf1; D1Ertd161e", "gene_names_refseq": "1300008P06Rik; 2810025E10Rik; Ankzf1; D1Ertd161e", "protein_names_uniprotkb": "tRNA endonuclease ANKZF1; 3.1.-.-; Ankyrin repeat and zinc finger domain-containing protein 1", "protein_names_refseq": "ankyrin repeat and zinc finger domain-containing protein 1; tRNA endonuclease ANKZF1 isoform 2; tRNA endonuclease ANKZF1", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589)", "pathway": " (mmu:52231)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;31219806;34428180;36210013;38407929", "class_list": "", "function": "Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation. The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts. ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs. ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1. Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NAT10-mediated ac[4]C-modified ANKZF1 promotes tumor progression and lymphangiogenesis in clear-cell renal cell carcinoma by attenuating YWHAE-driven cytoplasmic retention of YAP1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EKG0;Q9CZF5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0004521 RNA endonuclease activity;GO:0140101 catalytic activity, acting on a tRNA", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0070301 cellular response to hydrogen peroxide;GO:0036503 ERAD pathway;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins;GO:0042780 tRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80UU1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80VQ0-1", "uniprot_id": "AL3B1_MOUSE", "mass": 52292.0, "length": 468, "protein_name": "Aldehyde dehydrogenase family 3 member B1", "gene_name": "Aldh3b1", "organism": "Mouse", "refseq_name": "aldehyde dehydrogenase family 3 member B1", "refseq_ac": "NP_080592", "gene_names_uniprotkb": "Aldh3b1; Aldh7", "gene_names_refseq": "1700001N19Rik; ALDH4; ALDH7; Aldh3b1", "protein_names_uniprotkb": "Aldehyde dehydrogenase family 3 member B1; 1.2.1.28; 1.2.1.48; 1.2.1.5; 1.2.1.7; Aldehyde dehydrogenase 7; Long-chain fatty aldehyde dehydrogenase; Medium-chain fatty aldehyde dehydrogenase", "protein_names_refseq": "aldehyde dehydrogenase 7; aldehyde dehydrogenase family 3 member B1; long-chain fatty aldehyde dehydrogenase; medium-chain fatty aldehyde dehydrogenase", "tax_id": 10090, "disease": "Sjogren-Larsson syndrome (Disease Ontology:DOID:14501)", "pathway": " (mmu:67689); (R-MMU-6798695); (R-MMU-9845614)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "17382292;25286108;26740625;28011936;28935714;34428180;35984892", "class_list": "", "function": "Oxidizes medium and long chain saturated and unsaturated fatty aldehydes generated in the plasma membrane into non-toxic fatty acids (PubMed:17382292, PubMed:25286108). May have a protective role against the cytotoxicity induced by lipid peroxidation. Short-chain fatty aldehydes are not good substrates. Can use both NADP(+) and NAD(+) as electron acceptor in vitro, however in vivo preference will depend on their tissue levels. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. Able to metabolize aromatic aldehydes such as benzaldehyde to their acid form (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63ZW3;Q8VHW0;Q9CW05", "ec_number_list": "2.3.2.27;7.6.2.1;3.1.3.48;1.2.1.3;1.2.1.48;1.14.19.17;5.2.1.-;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.4.24.81;2.7.11.1;1.14.14.18;3.4.21.73;2.4.1.-;2.4.1.275;2.4.1.22;2.4.1.38;2.4.1.90;1.2.1.36;1.2.1.19;1.2.1.28;3.6.5.2;1.2.1.5;1.2.1.94;1.1.1.-;3.4.11.2;3.4.24.-;2.3.1.78;7.6.2.-;1.6.3.-;3.4.24.11;3.2.2.6;1.2.1.7;2.3.1.51;3.6.1.-;1.7.1.-;1.2.1.31;1.2.1.8;1.2.1.47;1.2.1.46;3.1.4.4;2.3.1.20;2.3.1.76", "go_molecular_function": "GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity;GO:0018479 benzaldehyde dehydrogenase (NAD+) activity;GO:0050061 long-chain fatty aldehyde dehydrogenase (NAD+) activity;GO:0052814 medium-chain fatty aldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006979 response to oxidative stress;GO:0006068 ethanol catabolic process;GO:0006081 aldehyde metabolic process;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q80VQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80W40-1", "uniprot_id": "ACSM4_MOUSE", "mass": 65427.0, "length": 580, "protein_name": "Acyl-coenzyme A synthetase ACSM4, mitochondrial", "gene_name": "Acsm4", "organism": "Mouse", "refseq_name": "acyl-coenzyme A synthetase ACSM4, mitochondrial precursor", "refseq_ac": "NP_848501", "gene_names_uniprotkb": "Acsm4; Omacs", "gene_names_refseq": "Acsm4; O-MACS; OMACS", "protein_names_uniprotkb": "Acyl-coenzyme A synthetase ACSM4, mitochondrial; 6.2.1.2; O-MACS; Olfactory specific medium-chain acyl CoA synthetase", "protein_names_refseq": "acyl-coenzyme A synthetase ACSM4, mitochondrial precursor; acyl-coenzyme A synthetase ACSM4, mitochondrial; olfactory specific medium-chain acyl CoA synthetase", "tax_id": 10090, "disease": "", "pathway": " (mmu:233801); (R-MMU-177128); (R-MMU-9749641)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;25428506", "class_list": "", "function": "Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids with a preference for C6-12 fatty acids (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.2.1.2;6.2.1.17;6.2.1.25;6.2.1.3;6.2.1.15", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0102391 decanoate-CoA ligase activity;GO:0004321 fatty-acyl-CoA synthase activity;GO:0015645 fatty acid ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80W40-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BUE4-1", "uniprot_id": "FSP1_MOUSE", "mass": 40635.0, "length": 373, "protein_name": "Ferroptosis suppressor protein 1", "gene_name": "Aifm2", "organism": "Mouse", "refseq_name": "ferroptosis suppressor protein 1 isoform 2", "refseq_ac": "NP_001034283", "gene_names_uniprotkb": "Aifm2; Amid", "gene_names_refseq": "5430437E11Rik; Aifm2; Amid; D730001I10Rik; FSP1; PRG3", "protein_names_uniprotkb": "Ferroptosis suppressor protein 1; 1.6.5.-; AMID; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; FSP1; p53-responsive gene 3 protein", "protein_names_refseq": "apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death; apoptosis-inducing factor 2; apoptosis-inducing factor homologous mitochondrion-associated inducer of death; apoptosis-inducing factor-like mitchondrion-associated inducer of death; apoptosis-inducing factor-like mitochondrion-associated inducer of death; ferroptosis suppressor protein 1 isoform 2; ferroptosis suppressor protein 1; p53-responsive gene 3 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:71361)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16186796;21366272;26168492;26689472;30084848;34428180;35922516;37619958;37957306", "class_list": "", "function": "4-hydroxy-2-nonenal adduction of AIFm2 shifts the function of AIFm2 from an NADH oxidoreductase to a proapototic protein., [RefSeq, PubMed]; A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis (PubMed:37957306). At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis (By similarity). Acts in parallel to GPX4 to suppress phospholipid peroxidation and ferroptosis (By similarity). This anti-ferroptotic function is independent of cellular glutathione levels (By similarity). Also acts as a potent radical-trapping antioxidant by mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle: catalyzes NAD(P)H-dependent reduction of vitamin K (phylloquinone, menaquinone-4 and menadione) to hydroquinone forms (PubMed:35922516). Hydroquinones act as potent radical-trapping antioxidants inhibitor of phospholipid peroxidation and ferroptosis (PubMed:26689472). May play a role in mitochondrial stress signaling (PubMed:26689472). Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death (PubMed:26689472)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; AMID is not required for normal development and p53-mediated tumor suppression., [RefSeq, PubMed]; Aifm2 may function in differentiation of erythroid murine erythroleukemia line cells in vitro., [RefSeq, PubMed]; Ferroptosis of macrophages facilitates bone loss in apical periodontitis via NRF2/FSP1/ROS pathway., [RefSeq, PubMed]; Results demonstrate nuclear AIF translocation only in PARG-null TS cells, which demonstrates the presence of AIF-mediated cell death., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHZ2", "ec_number_list": "1.6.5.2;1.6.5.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0050660 flavin adenine dinucleotide binding;GO:0004174 electron-transferring-flavoprotein dehydrogenase activity;GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005811 lipid droplet", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0008637 apoptotic mitochondrial changes;GO:1900407 regulation of cellular response to oxidative stress;GO:0042373 vitamin K metabolic process;GO:0006743 ubiquinone metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BUE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2K6-4", "uniprot_id": "AGFG1_MOUSE", "mass": 58043.0, "length": 561, "protein_name": "Arf-GAP domain and FG repeat-containing protein 1", "gene_name": "Agfg1", "organism": "Mouse", "refseq_name": "arf-GAP domain and FG repeat-containing protein 1 isoform 2", "refseq_ac": "NP_001297642", "gene_names_uniprotkb": "Agfg1; Hrb; Rip", "gene_names_refseq": "Agfg1; C130049H11Rik; D730048C23Rik; Hrb; RAB; Rip", "protein_names_uniprotkb": "Arf-GAP domain and FG repeat-containing protein 1; HIV-1 Rev-binding protein homolog; Nucleoporin-like protein RIP", "protein_names_refseq": "HIV-1 Rev binding protein; HIV-1 Rev-binding protein homolog; arf-GAP domain and FG repeat-containing protein 1 isoform 2; arf-GAP domain and FG repeat-containing protein 1; arf-GAP domain and FG repeats-containing protein 1; nucleoporin-like protein RIP", "tax_id": 10090, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311)", "pathway": " (mmu:15463); (R-MMU-8856828)", "pathway_count": 2, "publication_count": 34, "publication_id_list": "10.3389/fragi.2021.757801;11711676;17242355;18775314;19144319;19224205;20173027;20484733;21158410;21183079;21606357;22517741;22645316;22872234;25428506;25428507;26495903;27669760;28011936;30059200;30084848;30779550;31599954;32782141;32848054;33300544;34428180;34678516;35547804;35822049;36852467;40021952;40885482;9446614", "class_list": "", "function": "Required for docking and/or fusion of proacrosomic vesicles during acrosome biogenesis, [RefSeq, PubMed]; Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization., [UniProtKB, PubMed]; Study demonstrates that the clathrin-mediated endocytosis of the SNARE VAMP7 is directly mediated by Hrb, a clathrin adaptor and ArfGAP., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 16, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 16, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 16, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "O70448;Q8BQL5;Q8CDK9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0043025 neuronal cell body;GO:0031410 cytoplasmic vesicle;GO:0042995 cell projection", "go_biological_process": "GO:0001675 acrosome assembly;GO:0007289 spermatid nucleus differentiation;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 5.2, "record_id": "Q8K2K6-4", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2R9-1", "uniprot_id": "AP3M2_MOUSE", "mass": 46916.0, "length": 418, "protein_name": "AP-3 complex subunit mu-2", "gene_name": "Ap3m2", "organism": "Mouse", "refseq_name": "AP-3 complex subunit mu-2", "refseq_ac": "NP_001116292", "gene_names_uniprotkb": "Ap3m2", "gene_names_refseq": "5830445E16Rik; AP-3B; Ap3m2", "protein_names_uniprotkb": "AP-3 complex subunit mu-2; Adaptor-related protein complex 3 subunit mu-2; Clathrin assembly protein assembly protein complex 3 mu-2 medium chain; Clathrin coat assembly protein AP47 homolog 2; Clathrin coat-associated protein AP47 homolog 2; Golgi adaptor AP-1 47 kDa protein homolog 2; HA1 47 kDa subunit homolog 2; Mu3B-adaptin; P47B; m3B", "protein_names_refseq": "AP-3 complex subunit mu-2; HA1 47 kDa subunit homolog 2; P47B; adapter-related protein complex 3 mu-2 subunit; adapter-related protein complex 3 subunit mu-2; adaptor-related protein complex 3 subunit mu-2; clathrin assembly protein assembly protein complex 1 medium chain homolog 2; clathrin assembly protein assembly protein complex 3 mu-2 medium chain; clathrin coat assembly protein AP47 homolog 2; clathrin coat-associated protein AP47 homolog 2; golgi adaptor AP-1 47 kDa protein homolog 2; m3B; mu3B-adaptin", "tax_id": 10090, "disease": "", "pathway": " (mmu:64933)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21998198;24923803;31219806;33300544;34428180", "class_list": "", "function": "Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Ap47 is a subunit of the plasma membrane adaptor (By similarity). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals., [UniProtKB, PubMed]; We have demonstrated genetic and alcohol-induced regulation of Ap3m2 expression. Although sequence analysis revealed no polymorphisms in the Ap3m2-coding region that could account for all phenotypic differences, there are several upstream SNPs that could., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYJ3;Q923G7", "ec_number_list": "", "go_molecular_function": "GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005769 early endosome;GO:0005802 trans-Golgi network;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0008089 anterograde axonal transport;GO:0048490 anterograde synaptic vesicle transport;GO:0036465 synaptic vesicle recycling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R2R9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDL4-1", "uniprot_id": "ADPGK_MOUSE", "mass": 53902.0, "length": 496, "protein_name": "ADP-dependent glucokinase", "gene_name": "Adpgk", "organism": "Mouse", "refseq_name": "ADP-dependent glucokinase isoform 1 precursor", "refseq_ac": "NP_082397", "gene_names_uniprotkb": "Adpgk", "gene_names_refseq": "2610017G09Rik; Adp-gk; Adpgk", "protein_names_uniprotkb": "ADP-dependent glucokinase; 2.7.1.147; ADP-GK; ADPGK", "protein_names_refseq": "ADP-dependent glucokinase isoform 1 precursor; ATP-dependent glucokinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:72141); (R-MMU-70171)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14975750;16380121;21750661;25428506;26555263;30084848;32923109;34428180;37828378;39627609", "class_list": "", "function": "ADPGK is substrate inhibited by high glucose concentration and shows high specificity for glucose, with no activity for other sugars, as determined by NMR spectroscopy, including 2-deoxyglucose, [RefSeq, PubMed]; Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency., [UniProtKB, UniProtKB, UniProtKB]; Results suggest that sterol regulatory-element binding protein-1c is unlikely to be the mediator of the early insulin effect on glucokinase gene transcription., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7Y9;Q9D0H2", "ec_number_list": "2.7.1.147", "go_molecular_function": "GO:0046872 metal ion binding;GO:0043843 ADP-specific glucokinase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VDL4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920A7-1", "uniprot_id": "AFG31_MOUSE", "mass": 87047.0, "length": 789, "protein_name": "Mitochondrial inner membrane m-AAA protease component AFG3L1", "gene_name": "Afg3l1", "organism": "Mouse", "refseq_name": "mitochondrial inner membrane m-AAA protease component AFG3L1", "refseq_ac": "NP_473411", "gene_names_uniprotkb": "Afg3l1", "gene_names_refseq": "1700047G05Rik; 3110061K15Rik; Afg3l1", "protein_names_uniprotkb": "Mitochondrial inner membrane m-AAA protease component AFG3L1; 3.4.24.-; 3.6.-.-; AFG3-like protein 1", "protein_names_refseq": "AFG3(ATPase family gene 3)-like 1; AFG3-like protein 1; mitochondrial inner membrane m-AAA protease component AFG3L1", "tax_id": 10090, "disease": "spinocerebellar ataxia 28 (Disease Ontology:DOID:0050977); optic atrophy 12 (Disease Ontology:DOID:0080840); neurodegenerative disease (Disease Ontology:DOID:1289); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:114896)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11549317;17101804;19656850;22872234;27911893;30989755;31219806;34428180;36210013", "class_list": "", "function": "Afg3l1 encodes a protein that is targeted to the mitochondria and shows high homology to human paraplegin and other members of the ATP-dependent zinc metalloprotease family., [RefSeq, PubMed]; Astrocyte-specific deletion of Afg3l2 in the mouse leads to late-onset motor impairment and to degeneration of BG, which display aberrant morphology, altered expression of the glutamate transporter EAAT2, and a reactive inflammatory signature. The neurological and glial phenotypes are drastically exacerbated when astrocytes lack both Afg31l and Afg3l2, and therefore, are totally depleted of the m-AAA protease., [RefSeq, PubMed]; Catalytic component of the m-AAA protease, a protease that plays a key role in proteostasis of inner mitochondrial membrane proteins, and which is essential for axonal and neuron development (PubMed:11549317, PubMed:19656850). Afg3l1 possesses both ATPase and protease activities: the ATPase activity is required to unfold substrates, threading them into the internal proteolytic cavity for hydrolysis into small peptide fragments (By similarity). The m-AAA protease exerts a dual role in the mitochondrial inner membrane: it mediates the processing of specific regulatory proteins and ensures protein quality control by degrading misfolded polypeptides (By similarity). Required for SPG7 maturation into its active mature form after SPG7 cleavage by mitochondrial-processing peptidase (MPP) (PubMed:19656850)., [UniProtKB, PubMed, PubMed, UniProtKB]; Total ablation of the m-AAA protease, by deleting both Afg3l2 and its paralogue Afg3l1, triggers progressive motor dysfunction and demyelination, owing to rapid oligodendrocyte cell death. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THK2;Q6PGJ7;Q9CZN2", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0004176 ATP-dependent peptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005745 m-AAA complex", "go_biological_process": "GO:0016485 protein processing;GO:0007005 mitochondrion organization;GO:0008053 mitochondrial fusion;GO:0030163 protein catabolic process;GO:0034982 mitochondrial protein processing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q920A7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921Q3-1", "uniprot_id": "ALG1_MOUSE", "mass": 54417.0, "length": 482, "protein_name": "Chitobiosyldiphosphodolichol beta-mannosyltransferase", "gene_name": "Alg1", "organism": "Mouse", "refseq_name": "chitobiosyldiphosphodolichol beta-mannosyltransferase", "refseq_ac": "NP_663337", "gene_names_uniprotkb": "Alg1", "gene_names_refseq": "Alg1; HMAT1; HMT1", "protein_names_uniprotkb": "Chitobiosyldiphosphodolichol beta-mannosyltransferase; 2.4.1.142; Asparagine-linked glycosylation protein 1 homolog; Beta-1,4-mannosyltransferase; GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase; GDP-mannose-dolichol diphosphochitobiose mannosyltransferase", "protein_names_refseq": "GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase; GDP-mannose-dolichol diphosphochitobiose mannosyltransferase; asparagine-linked glycosylation 1 (beta-1,4-mannosyltransferase); asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase); asparagine-linked glycosylation protein 1 homolog; beta-1,4 mannosyltransferase; chitobiosyldiphosphodolichol beta-mannosyltransferase", "tax_id": 10090, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Ik (Disease Ontology:DOID:0080563); congenital disorder of glycosylation (Disease Ontology:DOID:5212)", "pathway": " (mmu:208211); (R-MMU-446193)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "34428180", "class_list": "glycogene;glycosyltransferase", "function": "Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the first mannose residues to the dolichol-linked oligosaccharide chain, to produce Man1GlcNAc(2)-PP-dolichol core oligosaccharide. Man1GlcNAc(2)-PP-dolichol is a substrate for ALG2, the following enzyme in the biosynthetic pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 31, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKT8", "ec_number_list": "2.4.1.142", "go_molecular_function": "GO:0000030 mannosyltransferase activity;GO:0004578 chitobiosyldiphosphodolichol beta-mannosyltransferase activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 15150, "hit_score": 0.2, "record_id": "Q921Q3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q924K1-1", "uniprot_id": "AIPL1_MOUSE", "mass": 38212.0, "length": 328, "protein_name": "Aryl-hydrocarbon-interacting protein-like 1", "gene_name": "Aipl1", "organism": "Mouse", "refseq_name": "aryl-hydrocarbon-interacting protein-like 1", "refseq_ac": "NP_444475", "gene_names_uniprotkb": "Aipl1", "gene_names_refseq": "A930007I01Rik; Aipl1", "protein_names_uniprotkb": "Aryl-hydrocarbon-interacting protein-like 1", "protein_names_refseq": "aryl-hydrocarbon-interacting protein-like 1", "tax_id": 10090, "disease": "Leber congenital amaurosis 4 (Disease Ontology:DOID:0110332); retinitis pigmentosa (Disease Ontology:DOID:10584); blindness (Disease Ontology:DOID:1432); Leber congenital amaurosis (Disease Ontology:DOID:14791)", "pathway": " (mmu:114230)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11420621;15365173;25428506;35065964", "class_list": "", "function": "Loss of AIPL1 would result in a condition that phenocopies retinal degenerations in the rd mouse and in a subgroup of human Erratum:[Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):515], [RefSeq, PubMed]; May be important in protein trafficking and/or protein folding and stabilization., [UniProtKB]; Molecular insights into the maturation of phosphodiesterase 6 by the specialized chaperone complex of HSP90 with AIPL1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RI54", "ec_number_list": "", "go_molecular_function": "GO:0001918 farnesylated protein binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007603 phototransduction, visible light;GO:0001895 retina homeostasis;GO:0018343 protein farnesylation;GO:0022400 regulation of opsin-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q924K1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KS6-1", "uniprot_id": "ADPRM_MOUSE", "mass": 38948.0, "length": 340, "protein_name": "Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase", "gene_name": "Adprm", "organism": "Mouse", "refseq_name": "manganese-dependent ADP-ribose/CDP-alcohol diphosphatase", "refseq_ac": "NP_079786", "gene_names_uniprotkb": "Adprm", "gene_names_refseq": "2310004I24Rik; Adprm; MDS006", "protein_names_uniprotkb": "Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase; 3.6.1.16; 3.6.1.53; ADPRibase-Mn; CDP-choline phosphohydrolase", "protein_names_refseq": "ADP-ribose/CDP-alcohol pyrophosphatase; ADPRibase-Mn; CDP-choline phosphohydrolase; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:66358); (R-MMU-2393930)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18352857;30059200;34428180", "class_list": "", "function": "Hydrolyzes ADP-ribose, ADP, CDP-glycerol, CDP-choline, CDP-ethanolamine and cyclic ADP-ribose (cADPR), but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress., [UniProtKB, UniProtKB]; The structure and function of Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase in immune tissues are reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5SUD1;Q9D7K9", "ec_number_list": "3.6.1.5;3.1.3.1;3.9.1.1;3.6.1.13;3.6.1.16;3.6.1.53;3.6.1.-;3.6.1.45;3.6.1.58;2.7.7.96;3.6.1.6", "go_molecular_function": "GO:0030145 manganese ion binding;GO:0047631 ADP-ribose diphosphatase activity;GO:0047734 CDP-glycerol diphosphatase activity;GO:0008663 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99KS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99NB1-1", "uniprot_id": "ACS2L_MOUSE", "mass": 74623.0, "length": 682, "protein_name": "Acetyl-coenzyme A synthetase 2-like, mitochondrial", "gene_name": "Acss1", "organism": "Mouse", "refseq_name": "acetyl-coenzyme A synthetase 2-like, mitochondrial precursor", "refseq_ac": "NP_542142", "gene_names_uniprotkb": "Acss1; Acas2l; Acas2", "gene_names_refseq": "1110032O15Rik; Acas2l; Acas2; AceCS2; Acss1", "protein_names_uniprotkb": "Acetyl-coenzyme A synthetase 2-like, mitochondrial; 6.2.1.17; 6.2.1.1; AceCS2; Acetate--CoA ligase 2; Acetyl-CoA synthetase 2; Acyl-CoA synthetase short-chain family member 1; Propionate--CoA ligase", "protein_names_refseq": "acetate--CoA ligase 2; acetyl-CoA synthetase 2; acetyl-coenzyme A synthetase 2-like, mitochondrial precursor; acetyl-coenzyme A synthetase 2-like, mitochondrial; propionate--CoA ligase", "tax_id": 10090, "disease": "", "pathway": " (mmu:68738); (R-MMU-71384)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11150295;14960588;16790548;19187775;34428180;36288343;37507081;37870960;38042218;38758779", "class_list": "", "function": "Activation of acetyl-CoA synthetase 2 mediates kidney injury in diabetic nephropathy. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:11150295, PubMed:16790548). Acetate is the preferred substrate (PubMed:11150295, PubMed:16790548). Can also utilize propionate with a much lower affinity (PubMed:11150295). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (PubMed:11150295). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (PubMed:19187775)., [UniProtKB, PubMed, PubMed, PubMed]; Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising biomarkers of sarcopenia in various models., [RefSeq, PubMed]; Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease., [RefSeq, PubMed]; Together with the trans-activation of the AceCS2 promoter, it is suggested that fasting-induced AceCS2 expression is largely contributed by KLF15, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0M6", "ec_number_list": "6.2.1.1;6.2.1.17;6.2.1.2;6.2.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0016208 AMP binding;GO:0003987 acetate-CoA ligase activity;GO:0050218 propionate-CoA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006068 ethanol catabolic process;GO:0006085 acetyl-CoA biosynthetic process;GO:0019413 acetate biosynthetic process;GO:0019427 acetyl-CoA biosynthetic process from acetate;GO:0019542 propionate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99NB1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQF6-1", "uniprot_id": "ADPPT_MOUSE", "mass": 35764.0, "length": 309, "protein_name": "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase", "gene_name": "Aasdhppt", "organism": "Mouse", "refseq_name": "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase isoform 2", "refseq_ac": "NP_001313288", "gene_names_uniprotkb": "Aasdhppt", "gene_names_refseq": "2010309J24Rik; 2810407B07Rik; AASD-PPT; Aasdhppt; CGI-80; LYS2; LYS5", "protein_names_uniprotkb": "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; 2.7.8.7; 4'-phosphopantetheinyl transferase; AASD-PPT; Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase", "protein_names_refseq": "4'-phosphopantetheinyl transferase; L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase isoform 2; L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:67618); (R-MMU-199220)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;25428506;34428180", "class_list": "", "function": "Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U5W8;Q9CU40;Q9D827", "ec_number_list": "1.1.1.100;1.3.1.39;2.3.1.38;2.3.1.39;2.3.1.41;2.3.1.85;3.1.2.14;4.2.1.59;2.7.8.7", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0008897 holo-[acyl-carrier-protein] synthase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0019878 lysine biosynthetic process via aminoadipic acid;GO:0009258 10-formyltetrahydrofolate catabolic process;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQF6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8B1-2", "uniprot_id": "AIG1_MOUSE", "mass": 27397.0, "length": 238, "protein_name": "Androgen-induced gene 1 protein", "gene_name": "Aig1", "organism": "Mouse", "refseq_name": "androgen-induced gene 1 protein isoform 2", "refseq_ac": "NP_001334291", "gene_names_uniprotkb": "Aig1", "gene_names_refseq": "1500031O19Rik; Aig1; CGI-103", "protein_names_uniprotkb": "Androgen-induced gene 1 protein; 3.1.-.-; AIG-1; FAHFA hydrolase AIG1; Fatty acid esters of hydroxy fatty acids hydrolase AIG1", "protein_names_refseq": "AIG-1; FAHFA hydrolase AIG1; androgen-induced gene 1 protein isoform 2; androgen-induced gene 1 protein; fatty acid esters of hydroxy fatty acids hydrolase AIG1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66253)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27040980;32152231", "class_list": "", "function": "AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice., [RefSeq, PubMed]; Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (By similarity). Shows a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (By similarity)., [UniProtKB, UniProtKB]; Immunoblotting of mouse tissues demonstrated highest expression of AIG1 in the liver, lung and heart. AIG1 has a complex genomic organization and expresses several splice variants in a tissue-dependent manner; AIG1 over-expression slightly increased susceptibility to oxidative stress. These results indicate that AIG1 plays a role in the control of the intracellular Ca(2+) concentration and cell death susceptibility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CI90;Q9CW23", "ec_number_list": "3.1.1.13;3.1.1.3;3.1.1.6;3.1.-.-", "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0042758 long-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D8B1-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9L5-1", "uniprot_id": "ACTT2_MOUSE", "mass": 41616.0, "length": 377, "protein_name": "Actin-related protein T2", "gene_name": "Actrt2", "organism": "Mouse", "refseq_name": "actin-related protein T2", "refseq_ac": "NP_082789", "gene_names_uniprotkb": "Actrt2; Arpm2", "gene_names_refseq": "1700052K15Rik; Actrt2; Arp-T2; Arpm2", "protein_names_uniprotkb": "Actin-related protein T2; ARP-T2; Actin-related protein M2", "protein_names_refseq": "actin related protein M2 (Arpm2); actin-related protein M2; actin-related protein T2", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy 11 (Disease Ontology:DOID:0110317); nemaline myopathy (Disease Ontology:DOID:3191); congenital structural myopathy (Disease Ontology:DOID:422); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:73353)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0015629 actin cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D9L5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESW4-1", "uniprot_id": "AGK_MOUSE", "mass": 46976.0, "length": 421, "protein_name": "Acylglycerol kinase, mitochondrial", "gene_name": "Agk", "organism": "Mouse", "refseq_name": "acylglycerol kinase, mitochondrial precursor", "refseq_ac": "NP_076027", "gene_names_uniprotkb": "Agk; Mulk", "gene_names_refseq": "2610037M15Rik; 6720408I04Rik; Agk; Mulk", "protein_names_uniprotkb": "Acylglycerol kinase, mitochondrial; 2.7.1.107; 2.7.1.138; 2.7.1.94; MuLK; Multi-substrate lipid kinase; Multiple substrate lipid kinase", "protein_names_refseq": "acylglycerol kinase, mitochondrial precursor; acylglycerol kinase, mitochondrial; multi-substrate lipid kinase; multiple substrate lipid kinase", "tax_id": 10090, "disease": "Sengers syndrome (Disease Ontology:DOID:0080132); cataract 38 (Disease Ontology:DOID:0110245)", "pathway": " (mmu:69923); (R-MMU-1483206)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15252046;16269826;18004883;21750661;24886245;25428506;26495903;32202634;37507081", "class_list": "", "function": "AGK promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1. Publication Status: Online-Only, [RefSeq, PubMed]; Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (PubMed:15252046). Phosphorylates ceramide but not sphingosine (PubMed:15252046). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol (PubMed:18004883). Independently of its lipid kinase activity, acts as a component of the TIM22 complex (By similarity). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (By similarity). In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23 (By similarity). Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; The role of AGK in thrombocytopoiesis and possible therapeutic strategies., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D087", "ec_number_list": "2.7.1.107;2.7.1.93;2.7.1.138;2.7.1.94", "go_molecular_function": "GO:0001727 lipid kinase activity;GO:0001729 ceramide kinase activity;GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0047620 acylglycerol kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005886 plasma membrane", "go_biological_process": "GO:0046834 lipid phosphorylation;GO:0045039 protein insertion into mitochondrial inner membrane;GO:0046513 ceramide biosynthetic process;GO:0046512 sphingosine biosynthetic process;GO:0046486 glycerolipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9ESW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0X2-1", "uniprot_id": "ADEC1_MOUSE", "mass": 52956.0, "length": 467, "protein_name": "ADAM DEC1", "gene_name": "Adamdec1", "organism": "Mouse", "refseq_name": "ADAM DEC1 precursor", "refseq_ac": "NP_067450", "gene_names_uniprotkb": "Adamdec1", "gene_names_refseq": "2210414L24Rik; Adamdec1; Dcsn", "protein_names_uniprotkb": "ADAM DEC1; 3.4.24.-; A disintegrin and metalloproteinase domain-like protein decysin-1; ADAM-like protein decysin-1", "protein_names_refseq": "ADAM DEC1 precursor; ADAM DEC1; ADAM-like protein decysin-1; a disintegrin and metalloproteinase domain-like protein decysin-1; decysin; disintegrin metalloprotease (decysin)", "tax_id": 10090, "disease": "", "pathway": " (mmu:58860)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11673514;12606478;30084848;35085231;35563399;38063920", "class_list": "", "function": "Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing. Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression. Publication Status: Online-Only, [RefSeq, PubMed]; May play an important role in the control of the immune response and during pregnancy., [UniProtKB]; Metalloendopeptidase ADAM-like Decysin 1 (ADAMDEC1) in Colonic Subepithelial PDGFRalpha(+) Cells Is a New Marker for Inflammatory Bowel Disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0006954 inflammatory response;GO:0030154 cell differentiation;GO:0030198 extracellular matrix organization;GO:0042060 wound healing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9R0X2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R144-1", "uniprot_id": "ANM2_MOUSE", "mass": 50476.0, "length": 448, "protein_name": "Protein arginine N-methyltransferase 2", "gene_name": "Prmt2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Prmt2; Hrmt1l1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein arginine N-methyltransferase 2; 2.1.1.319; Histone-arginine N-methyltransferase PRMT2", "protein_names_refseq": "", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841)", "pathway": "", "pathway_count": 0, "publication_count": 7, "publication_id_list": "16616919;16648481;20173027;20708585;20798359;21750661;34428180", "class_list": "", "function": "Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4 (PubMed:20798359). May inhibit NF-kappa-B transcription, and promote apoptosis (PubMed:16648481). Represses E2F1 transcriptional activity (in a RB1-dependent manner) (PubMed:16616919). Has a negative regulation effect on G1 to S transition of mitotic cell cycle (PubMed:16616919). Involved in growth regulation (PubMed:20708585). Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation (By similarity) Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation (By similarity). Enhances PGR, PPARG, RARA-mediated transactivation (By similarity). Involved in C15ORF39-mediated inhibition of the microglial inflammatory responses through suppression of NF-kappa-B signaling, thereby reducing the production of pro-inflammatory cytokines (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.319", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding;GO:0008013 beta-catenin binding;GO:0016274 protein-arginine N-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006954 inflammatory response;GO:0043065 positive regulation of apoptotic process;GO:0001666 response to hypoxia;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9R144-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVH6-1", "uniprot_id": "ANGP4_MOUSE", "mass": 57805.0, "length": 509, "protein_name": "Angiopoietin-4", "gene_name": "Angpt4", "organism": "Mouse", "refseq_name": "angiopoietin-4 precursor", "refseq_ac": "NP_033771", "gene_names_uniprotkb": "Angpt4; Agpt4; Ang3", "gene_names_refseq": "ANG-3; ANG-4; Agpt4; Ang3; Angpt4", "protein_names_uniprotkb": "Angiopoietin-4; ANG-3; ANG-4; Angiopoietin-3", "protein_names_refseq": "angiopoietin-3; angiopoietin-4 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:11602); (R-MMU-210993)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10051567;15280392;15284220;25428506;30444491;34146541;36190459;37155312;39950214", "class_list": "", "function": "ANGPTL4 regulates CD163 expression and Kuppfer cell polarization induced cirrhosis via TLR4/NF-kappaB pathway., [RefSeq, PubMed]; Angiopoietin-3 binds to the cell membrane via heparan sulfate proteoglycans, [RefSeq, PubMed]; Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis., [UniProtKB, PubMed]; Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm's Canal Maintenance., [RefSeq, PubMed]; Recombinant Ang3 formed disulfide-linked dimers. Ang3 was more potent than Ang4 in phosphorylating Akt in primary cultured mouse lung microvascular endothelial cells. It is a Tie2 agonist & causes corneal angiogenesis., [RefSeq, PubMed]; Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration., [RefSeq, PubMed]; This gene is a member of the angiopoietin family of secreted growth factors comprising Angiopoietins-1, -2, and -3, all of which bind the TEK Receptor Tyrosine Kinase. Angiopoietin/TEK Receptor Tyrosine Kinase signaling is involved in survival and migration of endothelial cells and regulates vascular remodeling and maintenance of vascular integrity. Angiopoietin/TEK Receptor Tyrosine Kinase signaling is also required for lymphangiogenesis. Family members bind TEK Receptor Tyrosine Kinase as multimeric clusters but their oligomerization properties differ from one another and this is thought to provide a mechanistic basis for their distinct physiologic roles. [provided by RefSeq, Jul 2016]., [RefSeq]; This study identifies Angpt4 as the first growth factor for venous-specific development and its importance in venous remodeling, retinal fluid clearance and neuronal function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030971 receptor tyrosine kinase binding;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity;GO:0048018 receptor ligand activity;GO:0005172 vascular endothelial growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0001525 angiogenesis;GO:0007165 signal transduction;GO:0007219 Notch signaling pathway;GO:0043066 negative regulation of apoptotic process;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9WVH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVP1-1", "uniprot_id": "AP1M2_MOUSE", "mass": 48137.0, "length": 423, "protein_name": "AP-1 complex subunit mu-2", "gene_name": "Ap1m2", "organism": "Mouse", "refseq_name": "AP-1 complex subunit mu-2 isoform 1", "refseq_ac": "NP_001103770", "gene_names_uniprotkb": "Ap1m2", "gene_names_refseq": "Ap1m2; D9Ertd818e; [m]1B; mu1B", "protein_names_uniprotkb": "AP-1 complex subunit mu-2; AP-mu chain family member mu1B; Adaptor protein complex AP-1 subunit mu-2; Adaptor-related protein complex 1 subunit mu-2; Clathrin assembly protein complex 1 mu-2 medium chain 2; Golgi adaptor HA1/AP1 adaptin mu-2 subunit; Mu-adaptin 2; Mu1B-adaptin", "protein_names_refseq": "AP-1 complex subunit mu-2 isoform 1; AP-1 complex subunit mu-2; AP-mu chain family member mu1B; adaptor protein complex AP-1 subunit mu-2; adaptor-related protein complex 1 mu-2 subunit; adaptor-related protein complex 1 subunit mu-2; adaptor-related protein complex AP-1, mu 2 subunit; clathrin assembly protein complex 1 medium chain 2; clathrin assembly protein complex 1 mu-2 medium chain 2; golgi adaptor HA1/AP1 adaptin mu-2 subunit; mu-adaptin 2; mu1B-adaptin", "tax_id": 10090, "disease": "", "pathway": " (mmu:11768); (R-MMU-2132295); (R-MMU-432720); (R-MMU-432722)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10338135;10640811;11964383;21750661;30084848;35820727;39059316;39369131", "class_list": "", "function": "AP-1B regulates interactions of epithelial cells and intraepithelial lymphocytes in the intestine. Publication Status: Online-Only, [RefSeq, PubMed]; Intestinal epithelium dysfunctions cause IgA deposition in the kidney glomeruli of intestine-specific Ap1m2-deficient mice., [RefSeq, PubMed]; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99LA4;Q9CWP7", "ec_number_list": "", "go_molecular_function": "GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0032588 trans-Golgi network membrane;GO:0005802 trans-Golgi network;GO:0030121 AP-1 adaptor complex;GO:0012505 endomembrane system", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0006896 Golgi to vacuole transport;GO:0110010 basolateral protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9WVP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35473-1", "uniprot_id": "C1D_MOUSE", "mass": 15945.0, "length": 141, "protein_name": "Nuclear nucleic acid-binding protein C1D", "gene_name": "C1d", "organism": "Mouse", "refseq_name": "nuclear nucleic acid-binding protein C1D", "refseq_ac": "NP_001317578", "gene_names_uniprotkb": "C1d; Suncor", "gene_names_refseq": "1110036E10Rik; C1d; SUN-CoR", "protein_names_uniprotkb": "Nuclear nucleic acid-binding protein C1D; Small unique nuclear receptor corepressor; Sun-CoR; SunCoR; mC1D", "protein_names_refseq": "nuclear DNA-binding protein; nuclear nucleic acid-binding protein C1D; small unique nuclear receptor corepressor", "tax_id": 10090, "disease": "", "pathway": " (mmu:57316); (R-MMU-6791226); (R-MMU-9930044)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10362552;21750661;34428180;9405624;9469821", "class_list": "", "function": "Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SWJ6;Q61368", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003714 transcription corepressor activity;GO:0016922 nuclear receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex;GO:0000178 exosome (RNase complex)", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0010468 regulation of gene expression;GO:0000460 maturation of 5.8S rRNA", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35473-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05928-1", "uniprot_id": "BTC_MOUSE", "mass": 19664.0, "length": 177, "protein_name": "Probetacellulin", "gene_name": "Btc", "organism": "Mouse", "refseq_name": "betacellulin preproprotein", "refseq_ac": "NP_031594", "gene_names_uniprotkb": "Btc; Bcn", "gene_names_refseq": "Bcn; Btc", "protein_names_uniprotkb": "Probetacellulin", "protein_names_refseq": "betacellulin preproprotein; probetacellulin", "tax_id": 10090, "disease": "otitis media (Disease Ontology:DOID:10754); insulinoma (Disease Ontology:DOID:3892); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12223); (R-MMU-1227986); (R-MMU-1236394); (R-MMU-1250196); (R-MMU-1250342); (R-MMU-1250347); (R-MMU-1257604); (R-MMU-177929); (R-MMU-179812); (R-MMU-180292); (R-MMU-180336); (R-MMU-182971); (R-MMU-1963640); (R-MMU-1963642); (R-MMU-212718); (R-MMU-5673001); (R-MMU-6785631); (R-MMU-6811558); (R-MMU-8847993); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8863795); (R-MMU-9009391)", "pathway_count": 23, "publication_count": 5, "publication_id_list": "12031500;20038432;21750661;21897861;8456283", "class_list": "", "function": "Betacellulin protects from pancreatitis by activating stress-activated protein kinase., [RefSeq, PubMed]; Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells., [UniProtKB, PubMed]; Structure of the BTC gene, [RefSeq, PubMed]; This gene encodes a member of the epidermal growth factor (EGF) family. These growth factors are ligands for the EGFR/ErbB receptor tyrosine kinases, and play roles in cell growth and differentiation. The encoded protein is synthesized as a transmembrane precursor that is proteolytically cleaved to generate a mature peptide, and plays a role in the differentiation of pancreatic beta cells. This gene may also play a protective role in acute pancreatitis, whereas increased expression of this gene may contribute to diabetic macular edema. Gene therapy using combinations of this gene and other pancreas-specific transcription factors may induce islet neogenesis and remediate hyperglycemia in type 1 diabetes. [provided by RefSeq, Apr 2011]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0035810 positive regulation of urine volume;GO:0045597 positive regulation of cell differentiation;GO:0007173 epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q05928-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0Q236-1", "uniprot_id": "BSPH2_MOUSE", "mass": 15641.0, "length": 131, "protein_name": "Binder of sperm protein homolog 2", "gene_name": "Bsph2", "organism": "Mouse", "refseq_name": "binder of sperm protein homolog 2 precursor", "refseq_ac": "NP_001074411", "gene_names_uniprotkb": "Bsph2", "gene_names_refseq": "9230107M04Rik; Bsph2a; Bsph2", "protein_names_uniprotkb": "Binder of sperm protein homolog 2", "protein_names_refseq": "binder of sperm protein homolog 2 precursor; bovine seminal plasma protein-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:77684)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17085770;21750661;24307707;29969530;32488144", "class_list": "", "function": "Binds sperm in vitro but has no effect on sperm capacitation. Also binds gelatin and heparin, but not chondroitin sulfate B or phospholipid liposomes., [UniProtKB, PubMed]; Epididymal proteins Binder of SPerm Homologs 1 and 2 (BSPH1/2) are dispensable for male fertility and sperm motility in mice. Publication Status: Online-Only, [RefSeq, PubMed]; These results show the existence of redundant function for murine BSPH2 and the lack of BSPH2 itself does not lead to sterility., [RefSeq, PubMed]; This study could lead to a better understanding of the role of BSP proteins in sperm functions and the existence of redundant BSP proteins in the reproductive tract. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface", "go_biological_process": "GO:0048240 sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q0Q236-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q173-1", "uniprot_id": "BTBDG_MOUSE", "mass": 60279.0, "length": 522, "protein_name": "BTB/POZ domain-containing protein 16", "gene_name": "Btbd16", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein 16 isoform 1", "refseq_ac": "NP_001074507", "gene_names_uniprotkb": "Btbd16", "gene_names_refseq": "Btbd16; E330040A16Rik", "protein_names_uniprotkb": "BTB/POZ domain-containing protein 16", "protein_names_refseq": "BTB (POZ) domain containing 16; BTB/POZ domain-containing protein 16 isoform 1; BTB/POZ domain-containing protein 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:330660)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q173-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30993-1", "uniprot_id": "C5AR1_MOUSE", "mass": 39023.0, "length": 351, "protein_name": "C5a anaphylatoxin chemotactic receptor 1", "gene_name": "C5ar1", "organism": "Mouse", "refseq_name": "C5a anaphylatoxin chemotactic receptor 1", "refseq_ac": "NP_001167021", "gene_names_uniprotkb": "C5ar1; C5ar; C5r1", "gene_names_refseq": "C5aR; C5ar1; C5r1; Cd88; D7Msu1", "protein_names_uniprotkb": "C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR", "protein_names_refseq": "C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin receptor; C5a ligand; C5a-R; complement component 5, receptor 1", "tax_id": 10090, "disease": "thrombosis (Disease Ontology:DOID:0060903); Alzheimer's disease (Disease Ontology:DOID:10652); adult respiratory distress syndrome (Disease Ontology:DOID:11394); neutropenia (Disease Ontology:DOID:1227); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); rhinitis (Disease Ontology:DOID:4483); lung disease (Disease Ontology:DOID:850); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12273); (R-MMU-375276); (R-MMU-418594); (R-MMU-6798695); (R-MMU-977606)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "1401897;16230349;19144319;21183079;21750661;34428180;37852260;39627609;40885482", "class_list": "", "function": "Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZ86", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004878 complement component C5a receptor activity;GO:0001856 complement component C5a binding;GO:0004875 complement receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0045177 apical part of cell;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0038178 complement component C5a signaling pathway;GO:0001774 microglial cell activation;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P30993-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AE42-1", "uniprot_id": "C56D1_MOUSE", "mass": 25519.0, "length": 229, "protein_name": "Probable transmembrane reductase CYB561D1", "gene_name": "Cyb561d1", "organism": "Mouse", "refseq_name": "probable transmembrane reductase CYB561D1 isoform 1", "refseq_ac": "NP_001074789", "gene_names_uniprotkb": "Cyb561d1", "gene_names_refseq": "1600010M23Rik; Cyb561d1", "protein_names_uniprotkb": "Probable transmembrane reductase CYB561D1; 7.2.1.3; Cytochrome b561 domain-containing protein 1", "protein_names_refseq": "cytochrome b561 domain-containing protein 1; probable transmembrane reductase CYB561D1 isoform 1; probable transmembrane reductase CYB561D1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72023)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable transmembrane reductase that may use ascorbate as an electron donor and transfer electrons across membranes to reduce monodehydro-L-ascorbate radical and iron cations Fe(3+) in another cellular compartment., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RPT5", "ec_number_list": "7.2.1.3", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0140575 transmembrane monodehydroascorbate reductase activity;GO:0140571 transmembrane ascorbate ferrireductase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2AE42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08ED0-1", "uniprot_id": "B2L15_MOUSE", "mass": 18300.0, "length": 167, "protein_name": "Bcl-2-like protein 15", "gene_name": "Bcl2l15", "organism": "Mouse", "refseq_name": "bcl-2-like protein 15 isoform 1", "refseq_ac": "NP_001136431", "gene_names_uniprotkb": "Bcl2l15; Gm566", "gene_names_refseq": "Bcl2l15; Bfk; Gm566", "protein_names_uniprotkb": "Bcl-2-like protein 15; Bcl-2 family kin; Bcl2-L-15; Bfk", "protein_names_refseq": "Bcl2-like 15; bcl-2 family kin; bcl-2-like protein 15 isoform 1; bcl-2-like protein 15; bcl2-L-15", "tax_id": 10090, "disease": "", "pathway": " (mmu:229672)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1A5A5;B0V3P5;Q8K186", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08ED0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07743-1", "uniprot_id": "BPIA2_MOUSE", "mass": 24753.0, "length": 235, "protein_name": "BPI fold-containing family A member 2", "gene_name": "Bpifa2", "organism": "Mouse", "refseq_name": "BPI fold-containing family A member 2 precursor", "refseq_ac": "NP_032979", "gene_names_uniprotkb": "Bpifa2; Bpifa2e; Psp", "gene_names_refseq": "Bpifa2e; Bpifa2; Psp", "protein_names_uniprotkb": "BPI fold-containing family A member 2; PSP; Parotid secretory protein", "protein_names_refseq": "BPI fold containing family A, member 2E; BPI fold-containing family A member 2 precursor; parotid secretory protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:19194); (R-MMU-6803157)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;2428613;2582349;32390232;9461541", "class_list": "", "function": "Has strong antibacterial activity against P.aeruginosa., [UniProtKB, UniProtKB]; The parotid secretory protein BPIFA2 is a salivary surfactant that affects lipopolysaccharide action., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AIF8;Q9D734", "ec_number_list": "", "go_molecular_function": "GO:0001530 lipopolysaccharide binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P07743-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50615-1", "uniprot_id": "BTG3_MOUSE", "mass": 28983.0, "length": 252, "protein_name": "Protein BTG3", "gene_name": "Btg3", "organism": "Mouse", "refseq_name": "protein BTG3", "refseq_ac": "NP_001284676", "gene_names_uniprotkb": "Btg3; Ana; Tob5", "gene_names_refseq": "ANA; Btg3; tob5", "protein_names_uniprotkb": "Protein BTG3; Abundant in neuroepithelium area protein; BTG family member 3; Protein Tob5", "protein_names_refseq": "B cell translocation gene 3; BTG family member 3; abundant in neuroepithelium area protein; protein BTG3", "tax_id": 10090, "disease": "", "pathway": " (mmu:12228)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19068083;21750661;25605945;31219806;33311481;34428180;38714880;9067576;9632145", "class_list": "", "function": "A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis., [RefSeq, PubMed]; Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma., [RefSeq, PubMed]; Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation. Publication Status: Online-Only, [RefSeq, PubMed]; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase., [UniProtKB]; This gene encodes B cell translocation gene 3, a member of the BTG gene family. This family is defined by a conserved N-terminal domain, known to bind transcription factors, and a less conserved C-terminal domain. This protein is thought to have anti-proliferative properties, and may be involved in regulating the G1-S transition to suppress cell cycle progression. Mice deficient for this gene display an increased incidence of lung cancers, and many human lung cancer cells exhibit decreased levels of B cell translocation gene 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 17. [provided by RefSeq, Jul 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62328", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0045930 negative regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P50615-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V079-1", "uniprot_id": "BBOF1_MOUSE", "mass": 62499.0, "length": 533, "protein_name": "Basal body-orientation factor 1", "gene_name": "Bbof1", "organism": "Mouse", "refseq_name": "basal body-orientation factor 1", "refseq_ac": "NP_082653", "gene_names_uniprotkb": "Bbof1; 2900006K08Rik; Ccdc176", "gene_names_refseq": "2900006K08Rik; Bbof1; Ccdc176", "protein_names_uniprotkb": "Basal body-orientation factor 1; Coiled-coil domain-containing protein 176", "protein_names_refseq": "basal body-orientation factor 1; coiled-coil domain containing 176; coiled-coil domain-containing protein 176", "tax_id": 10090, "disease": "", "pathway": " (mmu:72873)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;25428506;30084848;31219806;37198331;37494937", "class_list": "", "function": "BBOF1 is required for sperm motility and male fertility by stabilizing the flagellar axoneme in mice. Publication Status: Online-Only, [RefSeq, PubMed]; CCDC176 stabilizes microtubule doublets 1 and 9 to ensure proper sperm movement., [RefSeq, PubMed]; Plays an essential role in sperm motility and male fertility by stabilizing the sperm flagellar axonemal structure. May be required for the stability of ODF2 and MANS1 proteins. Dispensable for the assembly and function of motile cilia., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EKT3;Q9CUZ3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0036064 ciliary basal body", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0030317 flagellated sperm motility;GO:0007338 single fertilization;GO:0050821 protein stabilization;GO:0007026 negative regulation of microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3V079-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62951-1", "uniprot_id": "BLCAP_MOUSE", "mass": 9876.0, "length": 87, "protein_name": "Apoptosis inducing factor BLCAP", "gene_name": "Blcap", "organism": "Mouse", "refseq_name": "apoptosis inducing factor BLCAP", "refseq_ac": "NP_058612", "gene_names_uniprotkb": "Blcap; Bc10", "gene_names_refseq": "Bc10; Blcap", "protein_names_uniprotkb": "Apoptosis inducing factor BLCAP; BLCAP apoptosis inducing factor; Bc10; Bladder cancer 10 kDa protein; Bladder cancer-associated protein", "protein_names_refseq": "BLCAP apoptosis inducing factor; Blcapbladder cancer associated protein homolog; apoptosis inducing factor BLCAP; bladder cancer 10 kDa protein; bladder cancer associated protein homolog; bladder cancer related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:53619)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18836209;21750661;35664469", "class_list": "", "function": "Acts as a tumor suppressor; induces growth arrest at G(1)/S checkpoint and apoptosis via RB1-dependent and p53/TP53- and NF-kappa-B-independent mechanisms. Modulates expression of genes involved in the regulation of proliferation, cell cycle and apoptosis., [UniProtKB, UniProtKB]; Blcap is imprinted in mouse and human brain, but not in other mouse tissues., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AFZ4;O60629;Q3TD76;Q5XJG3;Q9D3B5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0030262 apoptotic nuclear changes", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62951-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70408-1", "uniprot_id": "CAD10_MOUSE", "mass": 88312.0, "length": 788, "protein_name": "Cadherin-10", "gene_name": "Cdh10", "organism": "Mouse", "refseq_name": "cadherin-10 preproprotein", "refseq_ac": "NP_001303687", "gene_names_uniprotkb": "Cdh10", "gene_names_refseq": "A830016G23Rik; C030003B10Rik; C030011H18Rik; Cdh10", "protein_names_uniprotkb": "Cadherin-10; T2-cadherin", "protein_names_refseq": "T2-cadherin; cadherin-10 preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:320873); (R-MMU-418990)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;16181616;16452087;21183079;21750661;25428506;30084848;30899004;8620560;8879495", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB]; This demonstration of a distinctive expression pattern of cadherin-10 suggests that it has a pivotal role in the development and maintenance of brain barriers., [RefSeq, PubMed]; This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is expressed in the blood-brain barrier and retinal endothelia suggesting a role in the development and maintenance of brain barrier. Alternative splicing results in multiple transcript variants. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 15. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 12, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUB3;Q80WS7", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005912 adherens junction;GO:0045202 synapse", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P70408-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54798-1", "uniprot_id": "BRS3_MOUSE", "mass": 44229.0, "length": 399, "protein_name": "Bombesin receptor subtype-3", "gene_name": "Brs3", "organism": "Mouse", "refseq_name": "bombesin receptor subtype-3", "refseq_ac": "NP_033896", "gene_names_uniprotkb": "Brs3", "gene_names_refseq": "BRS-3; Brs3", "protein_names_uniprotkb": "Bombesin receptor subtype-3; BRS-3", "protein_names_refseq": "bombesin receptor subtype-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:12209); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "30084848;34326065;34478905;9262170;9573346", "class_list": "", "function": "Cre Recombinase Driver Mice Reveal Lineage-Dependent and -Independent Expression of Brs3 in the Mouse Brain. Publication Status: Online-Only, [RefSeq, PubMed]; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB]; The effects of housing density on mouse thermal physiology depend on sex and ambient temperature., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O88790;Q544G9", "ec_number_list": "", "go_molecular_function": "GO:0008188 neuropeptide receptor activity;GO:0004946 bombesin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O54798-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54825-1", "uniprot_id": "BYST_MOUSE", "mass": 49784.0, "length": 436, "protein_name": "Bystin", "gene_name": "Bysl", "organism": "Mouse", "refseq_name": "bystin", "refseq_ac": "NP_058555", "gene_names_uniprotkb": "Bysl", "gene_names_refseq": "Bysl; Bys; Enp1", "protein_names_uniprotkb": "Bystin", "protein_names_refseq": "bystin", "tax_id": 10090, "disease": "", "pathway": " (mmu:53414); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17055491;17242206;17242355;19131326;19144319;21183079;26495903;31219806;34428180;36704911", "class_list": "", "function": "Bystin is expressed in luminal and glandular epithelia in the mouse uterus at peri-implantation stages. Targeted disruption of the moBysl resulted in embryonic lethality shortly after implantation., [RefSeq, PubMed]; Findings provide evidence for a crucial role of Bysl as an integral factor for ribosome biogenesis and suggest a critical dependence of blastocyst formation on active translation machinery, [RefSeq, PubMed]; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits., [UniProtKB, PubMed, PubMed]; Sarcomatoid renal cell tumor harboring a novel BYSL::TFEB fusion with concurrent TFEB amplification., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THF4;Q3UPY9;Q8VD68", "ec_number_list": "", "go_molecular_function": "GO:0030515 snoRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0045177 apical part of cell;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0008283 cell population proliferation;GO:0001829 trophectodermal cell differentiation;GO:0006364 rRNA processing;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O54825-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70355-1", "uniprot_id": "BTNL2_MOUSE", "mass": 50894.0, "length": 454, "protein_name": "Butyrophilin-like protein 2", "gene_name": "Btnl2", "organism": "Mouse", "refseq_name": "butyrophilin-like protein 2", "refseq_ac": "NP_524574", "gene_names_uniprotkb": "Btnl2; Gm315; Ng9", "gene_names_refseq": "BTL-II; BTLN2; Btl2; Btnl2; Gm315; NG9", "protein_names_uniprotkb": "Butyrophilin-like protein 2", "protein_names_refseq": "butyrophilin-like protein 2; butyrophylin-like MHC class II associated", "tax_id": 10090, "disease": "berylliosis (Disease Ontology:DOID:10322); sarcoidosis (Disease Ontology:DOID:11335); Graves' disease (Disease Ontology:DOID:12361); Kawasaki disease (Disease Ontology:DOID:13378); coronary artery disease (Disease Ontology:DOID:3393); tuberculosis (Disease Ontology:DOID:399); rheumatoid arthritis (Disease Ontology:DOID:7148); ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (mmu:547431); (R-MMU-8851680)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16751379;17237401;23359506;32976909;34312491;35017553", "class_list": "", "function": "BTNL2 is overexpressed during both the asymptomatic and symptomatic phase of the Mdr1a knockout model of spontaneous colitis. Soluble BTNL2-Fc protein inhibits proliferation of murine T4 cells from the spleen, mesenteric lymph node, and Peyer's patch., [RefSeq, PubMed]; Butyrophilin-like 2 modulates B7 costimulation to induce Foxp3 expression and regulatory T cell development in mature T cells., [RefSeq, PubMed]; Butyrophilin-like 2 regulates site-specific adaptations of intestinal gammadelta intraepithelial lymphocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Cancer cell-expressed BTNL2 facilitates tumour immune escape via engagement with IL-17A-producing gammadelta T cells. Publication Status: Online-Only, [RefSeq, PubMed]; Negative regulator of T-cell proliferation., [UniProtKB, PubMed, PubMed]; Structural Insights into N-terminal IgV Domain of BTNL2, a T Cell Inhibitory Molecule, Suggests a Non-canonical Binding Interface for Its Putative Receptors., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A6X8K1;Q3UW94", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production;GO:0042102 positive regulation of T cell proliferation;GO:0032743 positive regulation of interleukin-2 production;GO:0050860 negative regulation of T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O70355-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CG09-1", "uniprot_id": "C2C4D_MOUSE", "mass": 36865.0, "length": 341, "protein_name": "C2 calcium-dependent domain-containing protein 4D", "gene_name": "C2cd4d", "organism": "Mouse", "refseq_name": "C2 calcium-dependent domain-containing protein 4D", "refseq_ac": "NP_001129589", "gene_names_uniprotkb": "C2cd4d; Gm659", "gene_names_refseq": "C2cd4d; Gm659", "protein_names_uniprotkb": "C2 calcium-dependent domain-containing protein 4D", "protein_names_refseq": "C2 calcium-dependent domain-containing protein 4D", "tax_id": 10090, "disease": "", "pathway": " (mmu:271944)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0CG09-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15539-1", "uniprot_id": "C11B2_MOUSE", "mass": 57373.0, "length": 500, "protein_name": "Cytochrome P450 11B2, mitochondrial", "gene_name": "Cyp11b2", "organism": "Mouse", "refseq_name": "cytochrome P450 11B2, mitochondrial", "refseq_ac": "NP_034121", "gene_names_uniprotkb": "Cyp11b2; Cyp11b-2", "gene_names_refseq": "ALDOS; Cpn2; Cyp11b-2; Cyp11b2; Cyp11b", "protein_names_uniprotkb": "Cytochrome P450 11B2, mitochondrial; 1.14.15.4; 1.14.15.5; ALDOS; Aldosterone synthase; Aldosterone-synthesizing enzyme; CYPXIB2; Corticosterone 18-monooxygenase, CYP11B2; Cytochrome P-450Aldo; Cytochrome P-450C18; Cytochrome P450C11; Steroid 11-beta-hydroxylase, CYP11B2; Steroid 18-hydroxylase", "protein_names_refseq": "aldosterone synthase; aldosterone-synthesizing enzyme; corticosterone 18-monooxygenase, CYP11B2; cytochrome P-450Aldo; cytochrome P-450C18; cytochrome P450 11B2, mitochondrial; cytochrome P450C11; steroid 11-beta-hydroxylase, CYP11B2; steroid 18-hydroxylase; steroid-11-beta-hydroxylase", "tax_id": 10090, "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); adrenal cortical adenoma (Disease Ontology:DOID:0050891); stroke (Disease Ontology:DOID:0051061); corticosterone methyloxidase deficiency 1 (Disease Ontology:DOID:0080626); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); glucocorticoid-remediable aldosteronism (Disease Ontology:DOID:14080); renal tubular acidosis (Disease Ontology:DOID:14219); primary hyperaldosteronism (Disease Ontology:DOID:446); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); myocarditis (Disease Ontology:DOID:820); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:13072); (R-MMU-193993); (R-MMU-194002); (R-MMU-211976)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "1686470;2783417", "class_list": "", "function": "A cytochrome P450 monooxygenase that catalyzes the biosynthesis of aldosterone, the main mineralocorticoid in the human body responsible for salt and water homeostasis, thus involved in blood pressure regulation, arterial hypertension, and the development of heart failure. Catalyzes three sequential oxidative reactions of 11-deoxycorticosterone (21-hydroxyprogesterone), namely 11-beta hydroxylation, followed by two successive oxidations at C18 yielding 18-hydroxy and then 18-oxo intermediates (that would not leave the enzyme active site during the consecutive hydroxylation reactions), ending with the formation of aldosterone. Can also produce 18-hydroxycortisol and 18-oxocortisol, derived from successive oxidations of cortisol at C18, normally found at very low levels, but significantly increased in primary aldosteronism, the most common form of secondary hypertension. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). Besides its role in the biosynthesis of mineralocorticoids and glucocorticoids, it can also participate in the androgen metabolic pathway, converting testosterone (17beta-hydroxy-4-androsten-3-one) to 11beta,17beta-dihydroxyandrost-4-ene-3-one. Can also use progesterone as substrate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14AB5;Q64661", "ec_number_list": "1.14.15.4;1.14.15.5", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004507 steroid 11-beta-monooxygenase activity;GO:0008395 steroid hydroxylase activity;GO:0047783 corticosterone 18-monooxygenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0030425 dendrite", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin;GO:0042756 drinking behavior;GO:0006704 glucocorticoid biosynthetic process;GO:0006705 mineralocorticoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P15539-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16277-1", "uniprot_id": "BLK_MOUSE", "mass": 56674.0, "length": 499, "protein_name": "Tyrosine-protein kinase Blk", "gene_name": "Blk", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase Blk", "refseq_ac": "NP_031575", "gene_names_uniprotkb": "Blk", "gene_names_refseq": "Blk", "protein_names_uniprotkb": "Tyrosine-protein kinase Blk; 2.7.10.2; B lymphocyte kinase; p55-Blk", "protein_names_refseq": "B lymphoid kinase; b lymphocyte kinase; p55-Blk; tyrosine-protein kinase Blk", "tax_id": 10090, "disease": "maturity-onset diabetes of the young type 11 (Disease Ontology:DOID:0111109); intestinal cancer (Disease Ontology:DOID:10155); Goldenhar syndrome (Disease Ontology:DOID:2907); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:12143)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10449731;12563261;14662906;1506682;1537861;1714601;20173027;23562159;2404338;29187734;30084848;34428180;35820727;36210013;38078859;7524079;7565679;7592958;7608542;7690139;8195169;8639560;9177269;9636152;9660839", "class_list": "", "function": "BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP phosphorylation., [RefSeq, PubMed]; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (PubMed:12563261, PubMed:14662906, PubMed:2404338, PubMed:7608542, PubMed:7690139, PubMed:9636152). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:12563261, PubMed:14662906, PubMed:2404338, PubMed:7608542, PubMed:7690139). Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor (PubMed:12563261, PubMed:14662906, PubMed:2404338, PubMed:7608542, PubMed:7690139). Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207' (PubMed:7592958, PubMed:9177269). Also phosphorylates the immunoglobulin G receptor FCGR2 (By similarity). With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (PubMed:12563261, PubMed:14662906). Also contributes to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation (PubMed:7565679). In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (By similarity). Phosphorylates CGAS, promoting retention of CGAS in the cytosol (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2M8", "ec_number_list": "2.7.12.2;2.7.10.1;2.7.12.1;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.1;2.7.11.13;2.7.10.4;2.7.1.40;2.7.11.23", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0030154 cell differentiation;GO:0032024 positive regulation of insulin secretion;GO:0050853 B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P16277-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34821-1", "uniprot_id": "BMP8A_MOUSE", "mass": 44764.0, "length": 399, "protein_name": "Bone morphogenetic protein 8A", "gene_name": "Bmp8a", "organism": "Mouse", "refseq_name": "bone morphogenetic protein 8A isoform 2 preproprotein", "refseq_ac": "NP_031584", "gene_names_uniprotkb": "Bmp8a; Bmp-8; Bmp8", "gene_names_refseq": "Bmp7r1; Bmp8a; OP-2; OP2", "protein_names_uniprotkb": "Bone morphogenetic protein 8A; BMP-8A; OP-2; Osteogenic protein 2", "protein_names_refseq": "bone morphogenetic protein 8A isoform 2 preproprotein; osteogenic protein 2", "tax_id": 10090, "disease": "diabetes mellitus (Disease Ontology:DOID:9351); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12163)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12925636;1460021;21277400;28465413;8843393;9463357", "class_list": "", "function": "Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including spermatogenesis, osteogenesis, steroidogenesis as well as regulation of energy balance (PubMed:12925636, PubMed:28465413, PubMed:9463357). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A (By similarity). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. In addition, activates the SMAD2/3 pathway (PubMed:28465413)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in development of the reproductive system. Mice lacking a functional copy of this gene exhibit degeneration of germ cells and the epididymal epithelium. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 4. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0030509 BMP signaling pathway;GO:0007281 germ cell development;GO:0001649 osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P34821-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49003-1", "uniprot_id": "BMP5_MOUSE", "mass": 51512.0, "length": 452, "protein_name": "Bone morphogenetic protein 5", "gene_name": "Bmp5", "organism": "Mouse", "refseq_name": "bone morphogenetic protein 5 preproprotein", "refseq_ac": "NP_031581", "gene_names_uniprotkb": "Bmp5; Bmp-5", "gene_names_refseq": "Bmp5; se", "protein_names_uniprotkb": "Bone morphogenetic protein 5; BMP-5", "protein_names_refseq": "bone morphogenetic protein 5 preproprotein", "tax_id": 10090, "disease": "Meier-Gorlin syndrome (Disease Ontology:DOID:0060306); Marfan syndrome (Disease Ontology:DOID:14323); diabetes mellitus (Disease Ontology:DOID:9351); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12160)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;29321139;30097509;7958439", "class_list": "", "function": "Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis (PubMed:29321139, PubMed:7958439). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation (By similarity). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Mice with null mutations in this gene exhibit a short ear phenotype, which is characterized by reduced size of the external ear, altered size and shape of the sternum, and other skeletal and soft-tissue abnormalities. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8CCE0", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0070700 BMP receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031982 vesicle", "go_biological_process": "GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P49003-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54285-1", "uniprot_id": "CACB3_MOUSE", "mass": 54572.0, "length": 484, "protein_name": "Voltage-dependent L-type calcium channel subunit beta-3", "gene_name": "Cacnb3", "organism": "Mouse", "refseq_name": "voltage-dependent L-type calcium channel subunit beta-3 isoform 1", "refseq_ac": "NP_031607", "gene_names_uniprotkb": "Cacnb3; Cacnlb3", "gene_names_refseq": "Beta3; CAB3; Ca(v)beta3; Cacnb3; Cchb3", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit beta-3; CAB3; CCHB3; Calcium channel voltage-dependent subunit beta 3", "protein_names_refseq": "calcium channel voltage-dependent subunit beta 3; voltage-dependent L-type calcium channel subunit beta-3 isoform 1; voltage-dependent L-type calcium channel subunit beta-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:12297); (R-MMU-112308); (R-MMU-422356)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21750661;21831364;22645316;24751537;38957986;7490102;8617257", "class_list": "", "function": "Cavbeta3 Contributes to the Maintenance of the Blood-Brain Barrier and Alleviates Symptoms of Experimental Autoimmune Encephalomyelitis., [RefSeq, PubMed]; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:24751537). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation. Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G5E821", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0005246 calcium channel regulator activity;GO:0005245 voltage-gated calcium channel activity;GO:0008331 high voltage-gated calcium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:2000463 positive regulation of excitatory postsynaptic potential;GO:0006816 calcium ion transport;GO:0007268 chemical synaptic transmission;GO:0050852 T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P54285-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55105-1", "uniprot_id": "BMP8B_MOUSE", "mass": 44943.0, "length": 399, "protein_name": "Bone morphogenetic protein 8B", "gene_name": "Bmp8b", "organism": "Mouse", "refseq_name": "bone morphogenetic protein 8B preproprotein", "refseq_ac": "NP_031585", "gene_names_uniprotkb": "Bmp8b", "gene_names_refseq": "Bmp8b; Op3", "protein_names_uniprotkb": "Bone morphogenetic protein 8B; BMP-8B", "protein_names_refseq": "bone morphogenetic protein 8B preproprotein", "tax_id": 10090, "disease": "diabetes mellitus (Disease Ontology:DOID:9351); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12164)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10894154;11427739;22579288;25428506;30478315;32694734;35218946;38201894;8682296;8843393", "class_list": "", "function": "BMP8B Activates Both SMAD2/3 and NF-kappaB Signals to Inhibit the Differentiation of 3T3-L1 Preadipocytes into Mature Adipocytes. Publication Status: Online-Only, [RefSeq, PubMed]; BMP8b and NRG4 can be considered as interconnected regulators of neuro-vascular remodeling in adipose tissue and are potential therapeutic targets in obesity. Publication Status: Online-Only, [RefSeq, PubMed]; Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis., [RefSeq, PubMed]; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Involved in the generation of primordial germ cells; this function involves Bmp4 in a synergistic manner though separate receptor complexes seem to be involved. Required for the initiation and maintenance of spermatogenesis. Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Obesity induces resistance to central action of BMP8B through a mechanism involving the BBSome., [RefSeq, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein may play a role in the generation of primordial germ cells, and has been shown to stimulate thermogenesis in brown adipose tissue. Male mice lacking a functional copy of this gene exhibit variable degrees of germ-cell deficiency. Homozygous knockout mice of both sexes exhibit impaired thermogenesis and reduced metabolic rate, resulting in weight gain. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 4. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNM2", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007283 spermatogenesis;GO:0097009 energy homeostasis;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0030509 BMP signaling pathway;GO:0048598 embryonic morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P55105-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58544-1", "uniprot_id": "BTBD1_MOUSE", "mass": 53233.0, "length": 488, "protein_name": "BTB/POZ domain-containing protein 1", "gene_name": "Btbd1", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein 1", "refseq_ac": "NP_666305", "gene_names_uniprotkb": "Btbd1; Gsrp", "gene_names_refseq": "1190005H08Rik; Btbd1", "protein_names_uniprotkb": "BTB/POZ domain-containing protein 1; Glucose signal-repressing protein", "protein_names_refseq": "BTB (POZ) domain containing 1; BTB/POZ domain-containing protein 1; glucose signal-repressing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:83962); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "15486563;17462629;31219806;34428180;37290676", "class_list": "", "function": "BTBD1 is a key protein of balance between adipogenesis and myogenesis., [RefSeq, PubMed]; BTBD1 is essential for myogenic differentiation, [RefSeq, PubMed]; MiR-200b-5p inhibits tumor progression in salivary adenoid cystic carcinoma via targeting BTBD1., [RefSeq, PubMed]; Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (PubMed:15486563, PubMed:17462629). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (PubMed:15486563, PubMed:17462629)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6GQU7;Q8BTZ0;Q8K0J0", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0097602 cullin family protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007517 muscle organ development;GO:0016567 protein ubiquitination;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P58544-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97302-1", "uniprot_id": "BACH1_MOUSE", "mass": 81374.0, "length": 739, "protein_name": "Transcription regulator protein BACH1", "gene_name": "Bach1", "organism": "Mouse", "refseq_name": "transcription regulator protein BACH1", "refseq_ac": "NP_031546", "gene_names_uniprotkb": "Bach1", "gene_names_refseq": "6230421P05Rik; Bach1", "protein_names_uniprotkb": "Transcription regulator protein BACH1; BTB and CNC homolog 1", "protein_names_refseq": "BTB and CNC homolog 1; BTB and CNC homology 1 transcription factor; transcription regulator protein BACH1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12013); (R-MMU-9707616); (R-MMU-9708530)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10620011;11387216;19170764;21183079;31219806;34428180;38573338;38776730;8887638;9565602", "class_list": "", "function": "BACH1 transcriptionally upregulates FOSL2 to induce M2 macrophages phenotype by activating TGFbeta/SMAD signaling to promote the transformation of lung fibroblasts into myofibroblasts., [RefSeq, PubMed]; Bach1 forms a multivalent DNA binding complex and functions as an architectural transcription factor., [RefSeq, PubMed]; Bach1 generates multivalent DNA binding complex through protein-protein interaction mediated by its BTB/POZ domain, [RefSeq, PubMed]; Bach1 is a heme-binding transcription factor. DNA binding activity of Bach1 is inhibited by heme., [RefSeq, PubMed]; The Bach1/HO-1 pathway regulates oxidative stress and contributes to ferroptosis in doxorubicin-induced cardiomyopathy in H9c2 cells and mice., [RefSeq, PubMed]; Transcriptional regulator that acts as a repressor or activator, depending on the context (PubMed:19170764, PubMed:8887638). Binds to NF-E2 DNA binding sites (PubMed:19170764, PubMed:8887638). Plays important roles in coordinating transcription activation and repression by MAFK (PubMed:8887638). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P97302-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97361-1", "uniprot_id": "BPIA1_MOUSE", "mass": 28625.0, "length": 278, "protein_name": "BPI fold-containing family A member 1", "gene_name": "Bpifa1", "organism": "Mouse", "refseq_name": "BPI fold-containing family A member 1 precursor", "refseq_ac": "NP_035256", "gene_names_uniprotkb": "Bpifa1; Plunc; Splunc1", "gene_names_refseq": "Bpifa1; LUNX; NASG; Plunc; SPLUNC1; SPURT", "protein_names_uniprotkb": "BPI fold-containing family A member 1; Palate lung and nasal epithelium clone protein", "protein_names_refseq": "BPI fold-containing family A member 1 precursor; palate lung and nasal epithelium clone protein; palate, lung, and nasal epithelium associated; palate, lung, and nasal epithelium clone; palate, lung, and nasal epithelium expressed transcript; protein Plunc", "tax_id": 10090, "disease": "otitis media (Disease Ontology:DOID:10754)", "pathway": " (mmu:18843); (R-MMU-6803157)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10224143;11396972;15028288;23499554;25428506;29717993;31044023;32680508;34851736;38053993", "class_list": "", "function": "CC16 drives VLA-2-dependent SPLUNC1 expression. Publication Status: Online-Only, [RefSeq, PubMed]; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (By similarity). Plays a role in the innate immune responses of the upper airways (PubMed:23499554). Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae (PubMed:23499554). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (By similarity). Plays a role in the airway inflammatory response after exposure to irritants (By similarity). May attract macrophages and neutrophils (By similarity)., [UniProtKB, PubMed, UniProtKB]; Short palate, lung, and nasal epithelial clone 1 (SPLUNC1) level determines steroid-resistant airway inflammation in aging., [RefSeq, PubMed]; Splunc5, splunc1, and lplunc1 are expressed in unique domains along a continuous corridor of oral, lingual, pharyngeal, and respiratory epithelia, [RefSeq, PubMed]; The SPLUNC1-betaENaC complex prevents Burkholderia cenocepacia invasion in normal airway epithelia. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQJ2", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005902 microvillus", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0043129 surfactant homeostasis;GO:0045087 innate immune response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0050891 multicellular organismal-level water homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P97361-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97452-1", "uniprot_id": "BOP1_MOUSE", "mass": 82546.0, "length": 732, "protein_name": "Ribosome biogenesis protein BOP1", "gene_name": "Bop1", "organism": "Mouse", "refseq_name": "ribosome biogenesis protein BOP1", "refseq_ac": "NP_038509", "gene_names_uniprotkb": "Bop1; Kiaa0124", "gene_names_refseq": "Bop1; Erb1p; Kiaa0124; mKIAA0124", "protein_names_uniprotkb": "Ribosome biogenesis protein BOP1; Block of proliferation 1 protein", "protein_names_refseq": "block of proliferation 1 protein; ribosome biogenesis protein BOP1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12181); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10891491;11390653;12048210;15225545;17242355;17353269;18250455;18299400;21183079;21952136;22645316;25153642;26156959;28135057;28528544;30782837;31219806;31599954;33510838;34428180;37615370;38409361;9872334", "class_list": "", "function": "BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis. Publication Status: Online-Only, [RefSeq, PubMed]; BOP1 contributes to the activation of autophagy in polycystic ovary syndrome via nucleolar stress response. Publication Status: Online-Only, [RefSeq, PubMed]; BOP1 knockdown promoted down-regulation of the MAPK phosphatases DUSP4 and DUSP6 via a transcription-based mechanism, leading to increased MAPK signaling., [RefSeq, PubMed]; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome., [UniProtKB, HAMAP, PubMed, PubMed, PubMed]; New direct Wnt/beta-catenin target gene Bop1, which induced epithelial-mesenchymal transition, cell migration and experimental metastasis of Colorectal cancer cells was identified., [RefSeq, PubMed]; PDGF-C promotes cell proliferation partially via downregulating BOP1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TK87;Q6ZQI9;Q91X31", "ec_number_list": "", "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0005694 chromosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0008283 cell population proliferation;GO:0042273 ribosomal large subunit biogenesis;GO:1901796 regulation of signal transduction by p53 class mediator;GO:0006364 rRNA processing;GO:0000460 maturation of 5.8S rRNA", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P97452-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02105-1", "uniprot_id": "C1QC_MOUSE", "mass": 25992.0, "length": 246, "protein_name": "Complement C1q subcomponent subunit C", "gene_name": "C1qc", "organism": "Mouse", "refseq_name": "complement C1q subcomponent subunit C precursor", "refseq_ac": "NP_031600", "gene_names_uniprotkb": "C1qc; C1qg", "gene_names_refseq": "Adib; C1qc; C1qg; Ciqc", "protein_names_uniprotkb": "Complement C1q subcomponent subunit C", "protein_names_refseq": "adiponectin b; complement C1q subcomponent subunit C precursor; complement C1q subcomponent subunit C; complement component 1, q subcomponent, c polypeptide; complement component 1, q subcomponent, gamma polypeptide", "tax_id": 10090, "disease": "", "pathway": " (mmu:12262); (R-MMU-173623); (R-MMU-977606)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "1396691;26495903;28011936;31219806;33300544;34428180;8606057", "class_list": "", "function": "Core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The classical complement pathway is initiated by the C1Q subcomplex of the C1 complex, which specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens: C1QA, together with C1QB and C1QC, specifically recognizes and binds the Fc regions of IgG or IgM via its C1q domain. Immunoglobulin-binding activates the proenzyme C1R, which cleaves C1S, initiating the proteolytic cascade of the complement system. The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM. The C1Q subcomplex also recognizes and binds phosphatidylserine exposed on the surface of cells undergoing programmed cell death, possibly promoting activation of the complement system., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6DI63", "ec_number_list": "", "go_molecular_function": "GO:0001786 phosphatidylserine binding;GO:0001791 IgM binding;GO:0019864 IgG binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098888 extrinsic component of presynaptic membrane;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0030853 negative regulation of granulocyte differentiation;GO:0045650 negative regulation of macrophage differentiation;GO:0098883 synapse pruning;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q02105-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04211-1", "uniprot_id": "BTG2_MOUSE", "mass": 17682.0, "length": 158, "protein_name": "Protein BTG2", "gene_name": "Btg2", "organism": "Mouse", "refseq_name": "protein BTG2", "refseq_ac": "NP_031596", "gene_names_uniprotkb": "Btg2; Tis21", "gene_names_refseq": "APRO1; Btg2; Pc3; TIS21", "protein_names_uniprotkb": "Protein BTG2; BTG family member 2; NGF-inducible protein TIS21", "protein_names_refseq": "B cell translocation gene 2, anti-proliferative; BTG family member 2; NGF-inducible protein TIS21; protein BTG2", "tax_id": 10090, "disease": "acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); breast cancer (Disease Ontology:DOID:1612); brain ischemia (Disease Ontology:DOID:2316); renal cell carcinoma (Disease Ontology:DOID:4450); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (mmu:12227); (R-MMU-6804115)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1713584;25428506;38329343", "class_list": "", "function": "Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth (By similarity)., [UniProtKB]; MicroRNA-409-3p/BTG2 signaling axis improves impaired angiogenesis and wound healing in obese mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0008306 associative learning;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q04211-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2VLH6-1", "uniprot_id": "C163A_MOUSE", "mass": 120921.0, "length": 1121, "protein_name": "Scavenger receptor cysteine-rich type 1 protein M130", "gene_name": "Cd163", "organism": "Mouse", "refseq_name": "scavenger receptor cysteine-rich type 1 protein M130 isoform 2 precursor", "refseq_ac": "NP_444324", "gene_names_uniprotkb": "Cd163; M130", "gene_names_refseq": "CD163v2; CD163v3; Cd163", "protein_names_uniprotkb": "Scavenger receptor cysteine-rich type 1 protein M130", "protein_names_refseq": "scavenger receptor cysteine-rich type 1 protein M130 isoform 2 precursor; scavenger receptor cysteine-rich type 1 protein M130", "tax_id": 10090, "disease": "hemophagocytic lymphohistiocytosis (Disease Ontology:DOID:0050120); adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); traumatic brain injury (Disease Ontology:DOID:0081292); lepromatous leprosy (Disease Ontology:DOID:10887); brucellosis (Disease Ontology:DOID:11077); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); malaria (Disease Ontology:DOID:12365); uveitis (Disease Ontology:DOID:13141); diverticulitis of colon (Disease Ontology:DOID:13254); hidradenitis suppurativa (Disease Ontology:DOID:2280); acute pancreatitis (Disease Ontology:DOID:2913); glomerulonephritis (Disease Ontology:DOID:2921); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); pulmonary tuberculosis (Disease Ontology:DOID:2957); Ebola virus disease (Disease Ontology:DOID:4325); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); Whipple disease (Disease Ontology:DOID:8476); cutaneous leishmaniasis (Disease Ontology:DOID:9111); visceral leishmaniasis (Disease Ontology:DOID:9146); nasopharynx carcinoma (Disease Ontology:DOID:9261); brain disease (Disease Ontology:DOID:936); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:93671); (R-MMU-2168880)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11345593;12698011;21427223;26495903;30899004;38860377", "class_list": "", "function": "After shedding, the soluble form (sCD163) may play an anti-inflammatory role., [UniProtKB]; Assignment of the CD163 antigen to mouse chromosome 6 band F2., [RefSeq, PubMed]; CD163[+] Macrophages Induce Endothelial-to-Mesenchymal Transition in Atheroma., [RefSeq, PubMed]; Data show that telmisartan reduced the mRNA expression of CD11c and TNF-alpha, M1 macrophage markers, and significantly increased the expressions of M2 markers, such as CD163, CD209., [RefSeq, PubMed]; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 25, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A6H691;Q2VLH5;Q99MX8", "ec_number_list": "", "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006953 acute-phase response", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q2VLH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3KQP7-1", "uniprot_id": "SPO16_MOUSE", "mass": 21131.0, "length": 186, "protein_name": "Protein SPO16 homolog", "gene_name": "1700028K03Rik; Spo16", "organism": "Mouse", "refseq_name": "protein SPO16 homolog isoform 1", "refseq_ac": "NP_877422", "gene_names_uniprotkb": "1700028K03Rik; Spo16; Scre", "gene_names_refseq": "1700028K03Rik; SCRE; Spo16", "protein_names_uniprotkb": "Protein SPO16 homolog; Synaptonemal complex reinforcing element", "protein_names_refseq": "protein SPO16 homolog isoform 1; protein SPO16 homolog; synaptonemal complex reinforcing element; uncharacterized protein C1orf146 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:76421)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;30746471;30949703", "class_list": "", "function": "Plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC) thereby stabilizing SC, ensuring progression of meiotic prophase I in male and female germ cells (PubMed:30949703). Promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1 (PubMed:30746471). Required for the localization of TEX11 and MSH4 to recombination intermediates (PubMed:30746471)., [UniProtKB, PubMed, PubMed]; This paper reported the function of this gene in meiotic recombination. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X9D1;Q8CF32", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005694 chromosome", "go_biological_process": "GO:0007130 synaptonemal complex assembly;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3KQP7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3URV1-1", "uniprot_id": "BROMI_MOUSE", "mass": 148061.0, "length": 1296, "protein_name": "Protein broad-minded", "gene_name": "Tbc1d32", "organism": "Mouse", "refseq_name": "protein broad-minded", "refseq_ac": "NP_001028557", "gene_names_uniprotkb": "Tbc1d32; Bromi", "gene_names_refseq": "Bromi; C6orf170; D630037F22Rik; Tbc1d32; b2b2284Clo", "protein_names_uniprotkb": "Protein broad-minded; TBC1 domain family member 32", "protein_names_refseq": "protein broad-minded", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); Meckel syndrome (Disease Ontology:DOID:0050778); orofaciodigital syndrome IX (Disease Ontology:DOID:0060382); VACTERL association (Disease Ontology:DOID:14679); Bardet-Biedl syndrome (Disease Ontology:DOID:1935)", "pathway": " (mmu:544696)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20159594;25428506;29487109;31599954;34428180", "class_list": "", "function": "Bromi, a previously uncharacterized TBC domain-containing protein, is required for proper cellular responses to the highest levels of Shh signaling in the neural tube. (bromi, broad-minded), [RefSeq, PubMed]; Dzip1l interacts genetically with Bromi, and both have overlapping functions in ciliogenesis and neural tube patterning. Publication Status: Online-Only, [RefSeq, PubMed]; Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium", "go_biological_process": "GO:0007507 heart development;GO:0001822 kidney development;GO:0060041 retina development in camera-type eye;GO:0021915 neural tube development;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3URV1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UZ09-1", "uniprot_id": "C1RL_MOUSE", "mass": 53435.0, "length": 482, "protein_name": "Complement C1r subcomponent-like protein", "gene_name": "C1rl", "organism": "Mouse", "refseq_name": "complement C1r subcomponent-like protein precursor", "refseq_ac": "NP_851989", "gene_names_uniprotkb": "C1rl; C1rlp", "gene_names_refseq": "C1r-LP; C1rl1; C1rlp; C1rl", "protein_names_uniprotkb": "Complement C1r subcomponent-like protein; 3.4.21.-; C1r-LP; C1r-like protein", "protein_names_refseq": "C1r-like protein; complement C1r subcomponent-like protein precursor; complement C1r subcomponent-like protein; complement component 1, r subcomponent like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:232371)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12686506;34203471;34428180", "class_list": "", "function": "Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V019;Q7TT43;Q7TT44", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0072562 blood microparticle", "go_biological_process": "GO:0045087 innate immune response;GO:0031638 zymogen activation;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UZ09-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q497N6-1", "uniprot_id": "C295L_MOUSE", "mass": 61957.0, "length": 533, "protein_name": "CEP295 N-terminal-like protein", "gene_name": "Cep295nl", "organism": "Mouse", "refseq_name": "CEP295 N-terminal-like protein", "refseq_ac": "NP_067415", "gene_names_uniprotkb": "Cep295nl; Ddc8; Kiaa1731nl", "gene_names_refseq": "Cep295nl; Ddc8; FS39; Kiaa1731nl", "protein_names_uniprotkb": "CEP295 N-terminal-like protein; Differential display clone 8; KIAA1731 N-terminal like protein", "protein_names_refseq": "CEP295 N-terminal-like protein; KIAA1731 N-terminal like protein; differential display clone 8; testis specific protein, Ddc8; testis-specific protein DDC8", "tax_id": 10090, "disease": "", "pathway": " (mmu:58251)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16985004;19706271;21750661;34428180;9237247", "class_list": "", "function": "Results show Dcd8 was not testis specific., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97320", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0031514 motile cilium;GO:0005814 centriole", "go_biological_process": "GO:0046599 regulation of centriole replication", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q497N6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KKZ1-1", "uniprot_id": "CF107_MOUSE", "mass": 23026.0, "length": 196, "protein_name": "Cilia- and flagella-associated protein 107", "gene_name": "Cfap107", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 107", "refseq_ac": "NP_081332", "gene_names_uniprotkb": "Cfap107", "gene_names_refseq": "1700012P22Rik; Cfap107", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 107", "protein_names_refseq": "cilia- and flagella-associated protein 107; protein CFAP107; uncharacterized protein C1orf158 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69364)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "37295417;37865089;37989994", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A7Z7;Q08EE4;Q9DAD4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4KKZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61809-1", "uniprot_id": "CD5R1_MOUSE", "mass": 34031.0, "length": 307, "protein_name": "Cyclin-dependent kinase 5 activator 1", "gene_name": "Cdk5r1", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 5 activator 1", "refseq_ac": "NP_034001", "gene_names_uniprotkb": "Cdk5r1; Cdk5r; Nck5a", "gene_names_refseq": "Cdk5r1; Cdk5r; D11Bwg0379e; p25; p35", "protein_names_uniprotkb": "Cyclin-dependent kinase 5 activator 1; CDK5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunit; Tau protein kinase II 23 kDa subunit; p23", "protein_names_refseq": "CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 activator 1; cyclin-dependent kinase 5, regulatory subunit (p35) 1", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); trigeminal neuralgia (Disease Ontology:DOID:12098); neurodegenerative disease (Disease Ontology:DOID:1289); hypothyroidism (Disease Ontology:DOID:1459); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:12569); (R-MMU-399956); (R-MMU-6804756)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10830966;11882646;17143272;21750661;24235147;26469698;34428180;36210013;37377891;37924385;8661152", "class_list": "", "function": "P25/CDK5-mediated Tau Hyperphosphorylation in Both Ipsilateral and Contralateral Cerebra Contributes to Cognitive Deficits in Post-stroke Mice., [RefSeq, PubMed]; P35 is a Crucial Player in NK-cell Cytotoxicity and TGFbeta-mediated NK-cell Dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]; p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62938", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0003779 actin binding;GO:0019901 protein kinase binding;GO:0046875 ephrin receptor binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0021799 cerebral cortex radially oriented cell migration;GO:0009792 embryo development ending in birth or egg hatching;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway;GO:0031175 neuron projection development;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P61809-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CI95-1", "uniprot_id": "OSB11_MOUSE", "mass": 83629.0, "length": 751, "protein_name": "Oxysterol-binding protein-related protein 11", "gene_name": "Osbpl11", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Osbpl11", "gene_names_refseq": "", "protein_names_uniprotkb": "Oxysterol-binding protein-related protein 11; ORP-11; OSBP-related protein 11", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:106326); (R-MMU-9013407)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17242355;19131326;21183079;21750661;31599954;32782141;34428180;35820727", "class_list": "", "function": "Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage. Weakly binds 25-hydroxycholesterol. Interacts with OSBPL9 to function as lipid transfer proteins. Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0032934 sterol binding;GO:0008289 lipid binding;GO:0160270 phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006649 phospholipid transfer to membrane;GO:0055091 phospholipid homeostasis;GO:0045444 fat cell differentiation;GO:0070328 triglyceride homeostasis;GO:0097212 lysosomal membrane organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CI95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8H7-1", "uniprot_id": "OMA1_MOUSE", "mass": 58878.0, "length": 521, "protein_name": "Metalloendopeptidase OMA1, mitochondrial", "gene_name": "Oma1", "organism": "Mouse", "refseq_name": "metalloendopeptidase OMA1, mitochondrial isoform a precursor", "refseq_ac": "NP_080185", "gene_names_uniprotkb": "Oma1", "gene_names_refseq": "2010001O09Rik; MPRP-1; Oma1; ZMPOMA1", "protein_names_uniprotkb": "Metalloendopeptidase OMA1, mitochondrial; 3.4.24.-; Overlapping with the m-AAA protease 1 homolog", "protein_names_refseq": "OMA1 homolog, zinc metallopeptidase; metalloendopeptidase OMA1, mitochondrial isoform a precursor; metalloendopeptidase OMA1, mitochondrial; overlapping with the m-AAA protease 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67013); (R-MMU-169911); (R-MMU-9840373)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "20038678;22433842;24550258;24616225;24719224;25428506;26365306;26783299;26785494;30084848;30779550;31819158;33200421;34428180", "class_list": "", "function": "Metalloprotease that is part of the quality control system in the inner membrane of mitochondria (PubMed:20038678, PubMed:22433842, PubMed:24550258, PubMed:24616225, PubMed:24719224, PubMed:26785494). Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1 (PubMed:20038678, PubMed:22433842, PubMed:24550258, PubMed:24616225, PubMed:26785494). Involved in the fusion of the mitochondrial inner membranes by mediating cleavage of OPA1 at S1 position, generating the soluble OPA1 (S-OPA1), which cooperates with the membrane form (L-OPA1) to coordinate the fusion of mitochondrial inner membranes (PubMed:20038678, PubMed:24616225). Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1, leading to excess production of soluble OPA1 (S-OPA1) and negative regulation of mitochondrial fusion (PubMed:22433842, PubMed:24550258, PubMed:26783299, PubMed:26785494). Involved in mitochondrial safeguard in response to transient mitochondrial membrane depolarization (flickering) by catalyzing cleavage of OPA1, leading to excess production of S-OPA1, preventing mitochondrial hyperfusion (PubMed:33200421). Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae (By similarity). In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome (By similarity). May also cleave UQCC3 in response to mitochondrial depolarization (By similarity). Also acts as an activator of the integrated stress response (ISR): in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (By similarity). Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions (PubMed:22433842). Binds cardiolipin, possibly regulating its protein turnover (PubMed:31819158). Required for the stability of the respiratory supercomplexes (PubMed:26365306)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; OMA1 regulates OPA1 cleavage in the mitochondrial inner membrane., [RefSeq, PubMed]; This study shows that OMA1 plays an essential role in the proteolytic inactivation of the dynamin-related GTPase OPA1 and describes its unexpected role in energy metabolism, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UWN9", "ec_number_list": "3.4.24.-;3.6.-.-;3.6.5.5", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0033108 mitochondrial respiratory chain complex assembly;GO:0070585 protein localization to mitochondrion;GO:1901526 positive regulation of mitophagy;GO:0006629 lipid metabolic process;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9D8H7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52760-1", "uniprot_id": "RIDA_MOUSE", "mass": 14255.0, "length": 135, "protein_name": "2-iminobutanoate/2-iminopropanoate deaminase", "gene_name": "Rida", "organism": "Mouse", "refseq_name": "2-iminobutanoate/2-iminopropanoate deaminase", "refseq_ac": "NP_032313", "gene_names_uniprotkb": "Rida; Hrp12", "gene_names_refseq": "HR12; HRP12; Hrsp12; Rida", "protein_names_uniprotkb": "2-iminobutanoate/2-iminopropanoate deaminase; 3.5.99.10; Heat-responsive protein 12; Reactive intermediate imine deaminase A homolog; Translation inhibitor L-PSP ribonuclease", "protein_names_refseq": "2-iminobutanoate/2-iminopropanoate deaminase; heat-responsive protein 12; ribonuclease UK114; translation inhibitor L-PSP ribonuclease", "tax_id": 10090, "disease": "", "pathway": " (mmu:15473); (R-MMU-8849175)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "22645316;23806337;26495903;37453647;9141440", "class_list": "", "function": "Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage., [UniProtKB, UniProtKB]; Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q569N4", "ec_number_list": "3.5.99.10", "go_molecular_function": "GO:0036041 long-chain fatty acid binding;GO:0003729 mRNA binding;GO:0042802 identical protein binding;GO:0046914 transition metal ion binding;GO:0019239 deaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005777 peroxisome", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0050680 negative regulation of epithelial cell proliferation;GO:0017148 negative regulation of translation;GO:0006402 mRNA catabolic process;GO:0061157 mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P52760-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NXI6-1", "uniprot_id": "RPRD2_MOUSE", "mass": 156586.0, "length": 1469, "protein_name": "Regulation of nuclear pre-mRNA domain-containing protein 2", "gene_name": "Rprd2", "organism": "Mouse", "refseq_name": "regulation of nuclear pre-mRNA domain-containing protein 2 isoform 1", "refseq_ac": "NP_001074762", "gene_names_uniprotkb": "Rprd2; Kiaa0460", "gene_names_refseq": "2810036A19Rik; 4930535B03Rik; 6720469I21Rik; Rprd2; mKIAA0460", "protein_names_uniprotkb": "Regulation of nuclear pre-mRNA domain-containing protein 2", "protein_names_refseq": "regulation of nuclear pre-mRNA domain-containing protein 2 isoform 1; regulation of nuclear pre-mRNA domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:75137); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;17242355;18250455;19144319;21183079;21606357;21750661;22517741;22645316;23443134;24129315;25428506;25605945;29562282;30059200;30084848;31219806;32782141;32848054;33300544;34418053;34428180;34678516;36852467;40021952;40885482", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 15, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 15, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 15, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 32, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3L8;Q6ZQA7", "ec_number_list": "", "go_molecular_function": "GO:0000993 RNA polymerase II complex binding;GO:0099122 RNA polymerase II C-terminal domain binding", "go_cellular_component": "GO:0097550 transcription preinitiation complex", "go_biological_process": "GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "Q6NXI6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJ72-1", "uniprot_id": "RPRM_MOUSE", "mass": 11820.0, "length": 109, "protein_name": "Protein reprimo", "gene_name": "Rprm", "organism": "Mouse", "refseq_name": "protein reprimo", "refseq_ac": "NP_075885", "gene_names_uniprotkb": "Rprm", "gene_names_refseq": "2410012A13Rik; Reprimo; Rprm", "protein_names_uniprotkb": "Protein reprimo", "protein_names_refseq": "protein reprimo; reprimo, TP53 dependant G2 arrest mediator candidate", "tax_id": 10090, "disease": "", "pathway": " (mmu:67874)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10930422;15769996;15817611;16434975;21183079;36041213;38272326", "class_list": "", "function": "Induction by DNA damage and hypoxia suggest IGFBP-3 plays a role in the physiologic protection against aberrant cell growth., [RefSeq, PubMed]; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex., [UniProtKB, PubMed]; Oral administration of green tea or topical caffeine immediately after discontinuation of UVB treatment enhanced the rate and extent of disappearance of the mutant p53-positive patches on skin of hairless mice., [RefSeq, PubMed]; P53(R273H) binds directly to the relaxin promoter, further confirming a role for H2 relaxin signaling in p53(R273H)-mediated androgen-independent prostate cancer, [RefSeq, PubMed]; RPRM deletion preserves hematopoietic regeneration by promoting EGFR-dependent DNA repair and hematopoietic stem cell proliferation post ionizing radiation., [RefSeq, PubMed]; Reprimo (RPRM) mediates neuronal ferroptosis via CREB-Nrf2/SCD1 pathways in radiation-induced brain injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1G8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0007346 regulation of mitotic cell cycle;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JJ72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08608-1", "uniprot_id": "OAZ2_MOUSE", "mass": 21025.0, "length": 189, "protein_name": "Ornithine decarboxylase antizyme 2", "gene_name": "Oaz2", "organism": "Mouse", "refseq_name": "ornithine decarboxylase antizyme 2 isoform 1", "refseq_ac": "NP_035082", "gene_names_uniprotkb": "Oaz2; Sez15", "gene_names_refseq": "AZ-2; AZ2; Oaz2-ps; Oaz2; Sez15", "protein_names_uniprotkb": "Ornithine decarboxylase antizyme 2; AZ2; ODC-Az 2; Seizure-related protein 15", "protein_names_refseq": "ODC-Az 2; antizyme 2; ornithine decarboxylase antizyme 2 isoform 1; seizure-related protein 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:18247); (R-MMU-350562); (R-MMU-351202)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "16916800;18508777;19449338;19725046;19997757;21750661;24967154;8645260;9782076", "class_list": "", "function": "Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:16916800, PubMed:18508777, PubMed:24967154). Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:19449338)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The level of AZ2 mRNA decreased during mammary gland development., [RefSeq, PubMed]; The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]., [RefSeq]; The protein product is generated using polyamine-regulated programmed ribosomal frameshifting., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008073 ornithine decarboxylase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1902268 negative regulation of polyamine transmembrane transport;GO:0090316 positive regulation of intracellular protein transport;GO:0045732 positive regulation of protein catabolic process;GO:0006596 polyamine biosynthetic process;GO:0006595 polyamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O08608-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29121-1", "uniprot_id": "PCSK4_MOUSE", "mass": 73214.0, "length": 655, "protein_name": "Proprotein convertase subtilisin/kexin type 4", "gene_name": "Pcsk4", "organism": "Mouse", "refseq_name": "proprotein convertase subtilisin/kexin type 4 precursor", "refseq_ac": "NP_032819", "gene_names_uniprotkb": "Pcsk4; Nec-3; Nec3", "gene_names_refseq": "NEC 3; NEC3; PC4; Pcsk4; SPC5", "protein_names_uniprotkb": "Proprotein convertase subtilisin/kexin type 4; 3.4.21.-; KEX2-like endoprotease 3; NEC 3; Neuroendocrine convertase 3; Prohormone convertase 3", "protein_names_refseq": "KEX2-like endoprotease 3; neuroendocrine convertase 3; prohormone convertase 3; proprotein convertase subtilisin/kexin type 4 precursor", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:18551)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11164898;1372895;1448111;16371590;19342015;21080038;21302280;21750661;22357636;22827436;8020970;9192653", "class_list": "", "function": "CRES may be a regulator of PC4 in sperm-egg interaction and fertilization., [RefSeq, PubMed]; Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (PubMed:16371590, PubMed:19342015, PubMed:21302280, PubMed:9192653). Also plays a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (By similarity). May also participate in folliculogenesis in the ovaries (PubMed:11164898)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q62094", "ec_number_list": "3.4.21.94;3.4.21.75;3.4.21.-;3.4.21.93", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005788 endoplasmic reticulum lumen;GO:0001669 acrosomal vesicle;GO:0002080 acrosomal membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0009566 fertilization;GO:0016485 protein processing;GO:0016486 peptide hormone processing;GO:0007340 acrosome reaction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P29121-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C4V1-1", "uniprot_id": "RHG24_MOUSE", "mass": 84100.0, "length": 747, "protein_name": "Rho GTPase-activating protein 24", "gene_name": "Arhgap24", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 24 isoform 2", "refseq_ac": "NP_001273397", "gene_names_uniprotkb": "Arhgap24", "gene_names_refseq": "0610025G21Rik; Arhgap24", "protein_names_uniprotkb": "Rho GTPase-activating protein 24; Rho-type GTPase-activating protein 24", "protein_names_refseq": "rho GTPase-activating protein 24 isoform 2; rho-type GTPase-activating protein 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:231532); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "17242355;20173027;21183079;21750661;21911940;25428506;30084848;30779550;34418053;34428180", "class_list": "", "function": "Increased levels of active Rac1 and Cdc42 were measured in Arhgap24 knockdown experiments, which influenced podocyte cell shape and membrane dynamics., [RefSeq, PubMed]; Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CA50;Q8QZZ0", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005912 adherens junction;GO:0005925 focal adhesion;GO:0042995 cell projection", "go_biological_process": "GO:1900028 negative regulation of ruffle assembly;GO:0001525 angiogenesis;GO:0007165 signal transduction;GO:0030154 cell differentiation;GO:0035313 wound healing, spreading of epidermal cells", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8C4V1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U3N6-1", "uniprot_id": "AP4AT_MOUSE", "mass": 60761.0, "length": 573, "protein_name": "AP-4 complex accessory subunit Tepsin", "gene_name": "Tepsin", "organism": "Mouse", "refseq_name": "AP-4 complex accessory subunit tepsin", "refseq_ac": "NP_898960", "gene_names_uniprotkb": "Tepsin; 2410002I01Rik; Enthd2", "gene_names_refseq": "2410002I01Rik; Enthd2; Tepsin", "protein_names_uniprotkb": "AP-4 complex accessory subunit Tepsin; ENTH domain-containing protein 2", "protein_names_refseq": "AP-4 complex accessory subunit tepsin; ENTH domain containing 2; ENTH domain-containing protein 2; protein C17orf56 homolog; tetra-epsin", "tax_id": 10090, "disease": "", "pathway": " (mmu:78777)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1H2", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032588 trans-Golgi network membrane;GO:0031090 organelle membrane;GO:0030124 AP-4 adaptor complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3U3N6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR42-1", "uniprot_id": "ANKR1_MOUSE", "mass": 36004.0, "length": 319, "protein_name": "Ankyrin repeat domain-containing protein 1", "gene_name": "Ankrd1", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 1", "refseq_ac": "NP_038496", "gene_names_uniprotkb": "Ankrd1; Carp", "gene_names_refseq": "Alrp; Ankrd1; CARP; Crap; MARP1", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 1; Cardiac ankyrin repeat protein", "protein_names_refseq": "ankyrin repeat domain 1 (cardiac muscle); ankyrin repeat domain-containing protein 1; ankyrin-like repeat protein; cardiac ankyrin repeat protein; cardiac responsive adriamycin protein", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); spinal muscular atrophy (Disease Ontology:DOID:12377); dilated cardiomyopathy (Disease Ontology:DOID:12930); nemaline myopathy (Disease Ontology:DOID:3191); congenital structural myopathy (Disease Ontology:DOID:422)", "pathway": " (mmu:107765)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;39285846;39299480;9043061;9278441", "class_list": "", "function": "ANKRD1 aggravates renal ischaemia-reperfusion injury via promoting TRIM25-mediated ubiquitination of ACSL3., [RefSeq, PubMed]; Ankrd1 regulates endogenous cardiac regeneration in mice by modulating cyclin D1., [RefSeq, PubMed]; May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55014;Q3UIF7;Q3UJ39;Q792Q9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0031432 titin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001650 fibrillar center", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010976 positive regulation of neuron projection development;GO:0043065 positive regulation of apoptotic process;GO:0071466 cellular response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CR42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88509-1", "uniprot_id": "DNM3B_MOUSE", "mass": 97228.0, "length": 859, "protein_name": "DNA (cytosine-5)-methyltransferase 3B", "gene_name": "Dnmt3b", "organism": "Mouse", "refseq_name": "DNA (cytosine-5)-methyltransferase 3B isoform 2", "refseq_ac": "NP_001003960", "gene_names_uniprotkb": "Dnmt3b", "gene_names_refseq": "Dnmt3b; MmuIIIB", "protein_names_uniprotkb": "DNA (cytosine-5)-methyltransferase 3B; 2.1.1.37; DNA MTase MmuIIIB; DNA methyltransferase MmuIIIB; Dnmt3b; M.MmuIIIB", "protein_names_refseq": "DNA (cytosine-5)-methyltransferase 3B isoform 2; DNA (cytosine-5)-methyltransferase 3B; DNA MTase MmuIIIB; DNA methyltransferase MmuIIIB", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); facioscapulohumeral muscular dystrophy 4 (Disease Ontology:DOID:0060918); immunodeficiency-centromeric instability-facial anomalies syndrome 1 (Disease Ontology:DOID:0090008); lung cancer (Disease Ontology:DOID:1324); prostatitis (Disease Ontology:DOID:14654); congenital heart disease (Disease Ontology:DOID:1682); anxiety disorder (Disease Ontology:DOID:2030); endometriosis of uterus (Disease Ontology:DOID:288); endometriosis (Disease Ontology:DOID:289); thymoma (Disease Ontology:DOID:3275); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); schizophrenia (Disease Ontology:DOID:5419); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); gastric body carcinoma (Disease Ontology:DOID:6705); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); chronic myeloid leukemia (Disease Ontology:DOID:8552); skin melanoma (Disease Ontology:DOID:8923); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); acute myeloid leukemia (Disease Ontology:DOID:9119); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:13436); (R-MMU-212300); (R-MMU-4655427)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10555141;11836534;11919202;12567489;12867029;15456878;15671018;16085498;16357870;16567415;18056424;18567530;18814855;19798101;21666347;24463520;30084848;39023272;9662389", "class_list": "", "function": "DNA methylation of miR-181a-5p mediated by DNMT3b drives renal interstitial fibrosis developed from acute kidney injury., [RefSeq, PubMed]; Dnmt3bDelta6 could induce a hypomethylation status especially in in vitro manipulated embryos., [RefSeq, PubMed]; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Functions as a transcriptional corepressor by associating with ZHX1 (By similarity). Required for DUX4 silencing in somatic cells (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene results in severe developmental defects and loss of viability. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. There is a pseudogene for this gene located adjacent to this gene in the same region of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88510;O88511", "ec_number_list": "3.5.1.-;3.5.1.98;2.1.1.37;2.1.1.-;2.3.2.-;2.1.1.356;3.6.4.-", "go_molecular_function": "GO:0003886 DNA (cytosine-5-)-methyltransferase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000775 chromosome, centromeric region;GO:1902494 catalytic complex;GO:0000792 heterochromatin", "go_biological_process": "GO:0043045 epigenetic programming of gene expression;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0045666 positive regulation of neuron differentiation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "O88509-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4F1-1", "uniprot_id": "NTNG2_MOUSE", "mass": 66166.0, "length": 589, "protein_name": "Netrin-G2", "gene_name": "Ntng2", "organism": "Mouse", "refseq_name": "netrin-G2 isoform c precursor", "refseq_ac": "NP_001292734", "gene_names_uniprotkb": "Ntng2; Lmnt2", "gene_names_refseq": "2610016D08Rik; Lmnt2; Ntng2", "protein_names_uniprotkb": "Netrin-G2; Laminet-2", "protein_names_refseq": "laminet 2; netrin-G2 isoform c precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:171171)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11804778;11906208;16075062;16980967;17785411;17973922;21750661;24642214;30084848;30899004;31668703;31692205;40885482", "class_list": "", "function": "Axonal Ntng2 transneuronally determines lamina-specific subdendritic segments., [RefSeq, PubMed]; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites., [UniProtKB, PubMed, PubMed, PubMed]; Mice in which netrin-G2 has been genetically inhibited do not startle to an acoustic stimulus, but otherwise perform normally through a behavioral test battery. There were no inner ear structural abnormalities., [RefSeq, PubMed]; Selectively expressed in distinct neuronal subsets that include populations in forebrain, midbrain, hindbrain, spinal cord, and spinal ganglia, [RefSeq, PubMed]; The complementary expression patterns of Ntng1 and Ntng2 are determined by transcriptional cis-regulatory elements widely scattered in these loci. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene belongs to a subclass of the netrin family called netrin-G proteins. Unlike classic netrins, which act as diffusible chemoattractants, netrin-Gs are glycosylphosphatidylinositol-anchored membrane proteins that interact with specific transmembrane proteins. In mouse, this gene is preferentially expressed in the cerebral cortex, habenular nucleus and superior colliculus. Knockout mutant mice display a lack of behavioral startle in response to acoustic stimuli. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A2AKX0;Q8R4F2;Q8VIP6;Q8VIP7;Q8VIP8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0030424 axon;GO:0098685 Schaffer collateral - CA1 synapse", "go_biological_process": "GO:0007409 axonogenesis;GO:0009887 animal organ morphogenesis;GO:0050804 modulation of chemical synaptic transmission;GO:0010975 regulation of neuron projection development;GO:0009888 tissue development", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q8R4F1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1G6-1", "uniprot_id": "PDLI2_MOUSE", "mass": 37703.0, "length": 349, "protein_name": "PDZ and LIM domain protein 2", "gene_name": "Pdlim2", "organism": "Mouse", "refseq_name": "PDZ and LIM domain protein 2", "refseq_ac": "NP_001240665", "gene_names_uniprotkb": "Pdlim2", "gene_names_refseq": "4732462F18Rik; Pdlim2; Slim", "protein_names_uniprotkb": "PDZ and LIM domain protein 2; PDZ-LIM protein mystique", "protein_names_refseq": "PDZ and LIM domain protein 2; PDZ-LIM protein mystique; STAT-interacting LIM protein; mystique", "tax_id": 10090, "disease": "", "pathway": " (mmu:213019)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "15659642;15963787;17468759;19131326;20889505;21183079;21750661;28378844;29187734;30084848;31757943;32805696;32849529;33539325;34428180", "class_list": "", "function": "By 19 months of age, all PDLIM2-/- mice, compared to less than 10% of wild-type (WT) mice, spontaneously developed tumors. 50% of them were lung tumors. PDLIM2 -/- mice were also more sensitive to K-RasG12D-induced lung tumorigenesis Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown of Mystique 2 with small interfering RNA abrogated both adhesion and migration in MCF10A and MCF-7 cells, [RefSeq, PubMed]; PDLIM2 deficiency resulted in larger amounts of nuclear p65, defective p65 ubiquitination and augmented production of proinflammatory cytokines in response to innate stimuli, [RefSeq, PubMed]; PDLIM2 protects articular chondrocytes from lipopolysaccharide-induced apoptosis, degeneration and inflammatory injury through down-regulation of nuclear factor (NF)-kappaB signaling., [RefSeq, PubMed]; PDLIM2 repression by ROS in alveolar macrophages promotes lung tumorigenesis. Publication Status: Online-Only, [RefSeq, PubMed]; PDLIM7 Synergizes With PDLIM2 and p62/Sqstm1 to Inhibit Inflammatory Signaling by Promoting Degradation of the p65 Subunit of NF-kappaB. Publication Status: Online-Only, [RefSeq, PubMed]; Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity)., [UniProtKB]; SLIM is a novel ubiquitin E3 ligase whose targets include STAT proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0051393 alpha-actinin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0001725 stress fiber;GO:0030018 Z disc", "go_biological_process": "GO:0007507 heart development;GO:0030036 actin cytoskeleton organization;GO:0030163 protein catabolic process;GO:0061061 muscle structure development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8R1G6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4JK59-1", "uniprot_id": "TET2_MOUSE", "mass": 212130.0, "length": 1912, "protein_name": "Methylcytosine dioxygenase TET2", "gene_name": "Tet2", "organism": "Mouse", "refseq_name": "methylcytosine dioxygenase TET2 isoform 1", "refseq_ac": "NP_001035490", "gene_names_uniprotkb": "Tet2; Kiaa1546", "gene_names_refseq": "Ayu17-449; E130014J05Rik; Tet2; mKIAA1546", "protein_names_uniprotkb": "Methylcytosine dioxygenase TET2; 1.14.11.80; Protein Ayu17-449", "protein_names_refseq": "methylcytosine dioxygenase TET2 isoform 1; probable methylcytosine dioxygenase TET2; tet oncogene 2; tet oncogene family member 2", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); myelodysplastic syndrome (Disease Ontology:DOID:0050908); colon adenoma (Disease Ontology:DOID:0050912); chronic myelomonocytic leukemia (Disease Ontology:DOID:0080188); stomach cancer (Disease Ontology:DOID:10534); breast cancer (Disease Ontology:DOID:1612); myeloproliferative neoplasm (Disease Ontology:DOID:2226); colon adenocarcinoma (Disease Ontology:DOID:234); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); primary immunodeficiency disease (Disease Ontology:DOID:612); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:214133)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "16722336;20639862;21057493;21183079;21723200;21750661;21778364;21803851;21817016;23151479;23352454;23352810;23353889;24357321;25557551;25568311;27802388;30084848;30779550;31164154;34428180;34678516;36852467;40128797;40155743", "class_list": "", "function": "Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 69, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 69, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 69, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 18, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 15, "glyco_site_count": 68, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5R5;Q3U633;Q3UAI0;Q6ZPN2;Q8K2K3", "ec_number_list": "1.14.11.80", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0008198 ferrous iron binding;GO:0070579 DNA 5-methylcytosine dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0002318 myeloid progenitor cell differentiation;GO:0019858 cytosine metabolic process;GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 9.6, "record_id": "Q4JK59-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09103-1", "uniprot_id": "PDIA1_MOUSE", "mass": 57058.0, "length": 509, "protein_name": "Protein disulfide-isomerase", "gene_name": "P4hb", "organism": "Mouse", "refseq_name": "protein disulfide-isomerase precursor", "refseq_ac": "NP_035162", "gene_names_uniprotkb": "P4hb; Pdia1", "gene_names_refseq": "ERp59; P4hb; PDI; Pdia1; Thbp", "protein_names_uniprotkb": "Protein disulfide-isomerase; 5.3.4.1; Cellular thyroid hormone-binding protein; ER protein 59; ERp59; Endoplasmic reticulum resident protein 59; PDI; Prolyl 4-hydroxylase subunit beta; p55", "protein_names_refseq": "ER protein 59; cellular thyroid hormone-binding protein; endoplasmic reticulum resident protein 59; p55; prolyl 4-hydroxylase subunit beta; protein disulfide-isomerase precursor; protein disulfide-isomerase", "tax_id": 10090, "disease": "Cole-Carpenter syndrome (Disease Ontology:DOID:0060438)", "pathway": " (mmu:18453); (R-MMU-1650814); (R-MMU-264876); (R-MMU-3299685); (R-MMU-381426); (R-MMU-5358346); (R-MMU-8866423); (R-MMU-8957275); (R-MMU-8963888); (R-MMU-8964041); (R-MMU-9020591); (R-MMU-9020933)", "pathway_count": 12, "publication_count": 25, "publication_id_list": "21670307;21750661;22645316;2295602;23806337;25428507;25605945;26740625;2830592;29125738;32149426;33863978;34428180;35820727;36210013;36288343;37453647;37507081;37828378;38211723;38400621;39627609;39927985;40684658;7753822", "class_list": "", "function": "Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion., [RefSeq, PubMed]; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP (By similarity). Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307)., [UniProtKB, PubMed, UniProtKB]; Vascular protein disulfide isomerase A1 mediates endothelial dysfunction induced by angiotensin II in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q922C8", "ec_number_list": "3.4.24.81;3.6.4.-;5.3.4.1;3.4.21.69;3.1.-.-;2.7.11.1;1.11.1.27;1.16.3.1;1.11.1.9;1.16.3.4;3.4.21.-;2.4.1.145;3.1.1.4;3.1.1.3;1.8.3.2;3.1.1.98;3.2.1.51;3.4.21.112", "go_molecular_function": "GO:0003779 actin binding;GO:0005178 integrin binding;GO:0019899 enzyme binding;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0045785 positive regulation of cell adhesion;GO:2000406 positive regulation of T cell migration;GO:0071456 cellular response to hypoxia;GO:0046598 positive regulation of viral entry into host cell;GO:1900026 positive regulation of substrate adhesion-dependent cell spreading", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P09103-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27773-1", "uniprot_id": "PDIA3_MOUSE", "mass": 56678.0, "length": 505, "protein_name": "Protein disulfide-isomerase A3", "gene_name": "Pdia3", "organism": "Mouse", "refseq_name": "protein disulfide-isomerase A3 precursor", "refseq_ac": "NP_031978", "gene_names_uniprotkb": "Pdia3; Erp60; Erp; Grp58", "gene_names_refseq": "58kDa; ERp57; ERp60; ERp61; Erp; Grp58; PDI-Q2; PDI; PI-PLC; PLC[a]; Pdia3; Plca", "protein_names_uniprotkb": "Protein disulfide-isomerase A3; 5.3.4.1; 58 kDa glucose-regulated protein; 58 kDa microsomal protein; Disulfide isomerase ER-60; ER protein 57; ER protein 60; ERp57; ERp60; Endoplasmic reticulum resident protein 57; Endoplasmic reticulum resident protein 60; p58", "protein_names_refseq": "58 kDa glucose-regulated protein; 58 kDa microsomal protein; ER protein 57; ER protein 60; disulfide isomerase ER-60; endoplasmic reticulum protein; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60; glucose regulated protein, 58 kDa; p58; phospholipase C, alpha; protein disulfide-isomerase A3 precursor; protein disulfide-isomerase A3", "tax_id": 10090, "disease": "asphyxia neonatorum (Disease Ontology:DOID:11088); autoimmune hepatitis (Disease Ontology:DOID:2048); post-traumatic stress disorder (Disease Ontology:DOID:2055); liver cirrhosis (Disease Ontology:DOID:5082); pulmonary hypertension (Disease Ontology:DOID:6432); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (mmu:14827); (R-MMU-1236974); (R-MMU-901042); (R-MMU-983170)", "pathway_count": 4, "publication_count": 45, "publication_id_list": "12648094;16479539;17322886;18250455;18299400;19224205;19801983;20173027;2033248;20400973;20484733;21093319;21750661;21952136;22645316;22872234;23395171;23806337;25428506;25605945;26495903;26740625;28011936;30084848;30779550;31219806;31599954;32152506;33725478;34203471;34428180;34887587;35820727;35984892;36210013;36288343;37453647;37507081;37828378;38669864;38830571;39293433;39927985;7523108;8746565", "class_list": "glycogene", "function": "Endoplasmic reticulum protein of 57 kDa sulfhydration promotes intestinal calcium absorption to attenuate primary osteoporosis., [RefSeq, PubMed]; May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin., [UniProtKB, UniProtKB]; PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders., [RefSeq, PubMed]; Protein disulfide isomerase A1 regulates fenestration dynamics in primary mouse liver sinusoidal endothelial cells (LSECs)., [RefSeq, PubMed]; Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEI9;Q3TIL2;Q3UZK8;Q8C2F4;Q99LF6", "ec_number_list": "3.6.4.10;7.4.2.14;5.3.4.1", "go_molecular_function": "GO:0019153 protein-disulfide reductase (glutathione) activity;GO:0042802 identical protein binding;GO:0008233 peptidase activity;GO:0015035 protein-disulfide reductase activity;GO:0042288 MHC class I protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005790 smooth endoplasmic reticulum", "go_biological_process": "GO:1903334 positive regulation of protein folding;GO:0002250 adaptive immune response;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway;GO:0006457 protein folding;GO:0070527 platelet aggregation", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "P27773-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ER64-1", "uniprot_id": "OSBL5_MOUSE", "mass": 98922.0, "length": 874, "protein_name": "Oxysterol-binding protein-related protein 5", "gene_name": "Osbpl5", "organism": "Mouse", "refseq_name": "oxysterol-binding protein-related protein 5 isoform 2", "refseq_ac": "NP_001186156", "gene_names_uniprotkb": "Osbpl5; Obph1; Osbp2", "gene_names_refseq": "1110006M06Rik; ORP5; Obph1; Osbp2; Osbpl5", "protein_names_uniprotkb": "Oxysterol-binding protein-related protein 5; ORP-5; OSBP-related protein 5; Oxysterol-binding protein homolog 1", "protein_names_refseq": "ORP-5; OSBP-related protein 5; oxysterol binding protein 2; oxysterol binding protein homolog 1; oxysterol-binding protein-like protein 5; oxysterol-binding protein-related protein 5 isoform 2; oxysterol-binding protein-related protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:79196); (R-MMU-1482801)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11063728;12504849;18024232;21183079;21750661", "class_list": "", "function": "Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes. Binds 25-hydroxycholesterol and cholesterol., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; OBPH1/Obph1 gene is imprinted, with preferential expression from the maternal allele in human and mouse., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R510;Q99NF5", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0001786 phosphatidylserine binding;GO:0140343 phosphatidylserine transfer activity;GO:0160270 phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0140268 endoplasmic reticulum-plasma membrane contact site;GO:1990351 transporter complex", "go_biological_process": "GO:0015914 phospholipid transport;GO:0120010 intermembrane phospholipid transfer;GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9ER64-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70250-1", "uniprot_id": "PGAM2_MOUSE", "mass": 28827.0, "length": 253, "protein_name": "Phosphoglycerate mutase 2", "gene_name": "Pgam2", "organism": "Mouse", "refseq_name": "phosphoglycerate mutase 2", "refseq_ac": "NP_061358", "gene_names_uniprotkb": "Pgam2", "gene_names_refseq": "Pgam2", "protein_names_uniprotkb": "Phosphoglycerate mutase 2; 5.4.2.11; 5.4.2.4; BPG-dependent PGAM 2; Muscle-specific phosphoglycerate mutase; PGAM-M; Phosphoglycerate mutase isozyme M", "protein_names_refseq": "BPG-dependent PGAM 2; PGAM-M; muscle-specific phosphoglycerate mutase; phosphoglycerate mutase 2; phosphoglycerate mutase isozyme M; phosphoglycerate mutase muscle-specific subunit", "tax_id": 10090, "disease": "myoglobinuria (Disease Ontology:DOID:0080108)", "pathway": " (mmu:56012); (R-MMU-70171); (R-MMU-70263)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "11250083;21183079;22645316;23446454;25428506;25605945;33725478;33914812;34428180;35547804;36288343;37507081;39927985", "class_list": "", "function": "Catalyzes the interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate, but with a reduced activity., [UniProtKB, UniProtKB]; Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.4.2.11;5.4.2.4", "go_molecular_function": "GO:0004082 bisphosphoglycerate mutase activity;GO:0004619 phosphoglycerate mutase activity;GO:0016787 hydrolase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:1990917 ooplasm", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0007283 spermatogenesis;GO:0006094 gluconeogenesis;GO:0006096 glycolytic process;GO:0006941 striated muscle contraction", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O70250-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQX4-1", "uniprot_id": "PAF15_MOUSE", "mass": 11993.0, "length": 110, "protein_name": "PCNA-associated factor", "gene_name": "Pclaf", "organism": "Mouse", "refseq_name": "PCNA-associated factor", "refseq_ac": "NP_080791", "gene_names_uniprotkb": "Pclaf; Ns5atp9; Paf", "gene_names_refseq": "2810417H13Rik; Ns5apt9; Ns5atp9; PAF15; Paf; Pclaf; mKIAA0101; p15(PAF)", "protein_names_uniprotkb": "PCNA-associated factor; HCV NS5A-transactivated protein 9 homolog; PAF15; PCNA-associated factor of 15 kDa; PCNA-clamp-associated factor; p15PAF", "protein_names_refseq": "HCV NS5A-transactivated protein 9 homolog; PCNA-associated factor of 15 kDa; PCNA-associated factor; p15PAF", "tax_id": 10090, "disease": "", "pathway": " (mmu:68026); (R-MMU-5656169)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16815099;23806337;28528544", "class_list": "", "function": "Highly restricted expression of the p15(PAF) gene in a spatio-temporal manner during embryogenesis, [RefSeq, PubMed]; PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4VAG2;Q9CZ17;Q9D0A5", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0006974 DNA damage response;GO:0009411 response to UV;GO:0007098 centrosome cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CQX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35730-1", "uniprot_id": "RING1_MOUSE", "mass": 42631.0, "length": 406, "protein_name": "E3 ubiquitin-protein ligase RING1", "gene_name": "Ring1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RING1", "refseq_ac": "NP_033092", "gene_names_uniprotkb": "Ring1; Ring1A; Rnf1", "gene_names_refseq": "Ring1A; Ring1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RING1; 2.3.2.27; Polycomb complex protein RING1; RING finger protein 1; RING-type E3 ubiquitin transferase RING1; Transcription repressor Ring1A", "protein_names_refseq": "E3 ubiquitin-protein ligase RING1; RING-type E3 ubiquitin transferase RING1; polycomb complex protein RING1; transcription repressor Ring1A", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); Luo-Schoch-Yamamoto syndrome (Disease Ontology:DOID:0070416); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:19763); (R-MMU-3108214); (R-MMU-3899300); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-8939243); (R-MMU-8943724); (R-MMU-8953750)", "pathway_count": 8, "publication_count": 9, "publication_id_list": "15525528;16359901;16710298;20485683;21183079;31219806;34428180;37655448;9312051", "class_list": "", "function": "Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity)., [UniProtKB, PubMed, PubMed, PubMed]; Ring1a protects against colitis through regulating mucosal immune system and colonic microbial ecology., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U242;Q3U333;Q4FK33;Q63ZX8;Q921Z8", "ec_number_list": "2.3.1.48;2.3.1.-;3.5.1.-;3.5.1.98;2.3.2.27;2.7.11.1;2.3.2.-;1.1.1.-;2.1.1.367;2.1.1.-;2.1.1.364;2.1.1.356;2.3.1.57", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0097027 ubiquitin-protein transferase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0016604 nuclear body", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0009952 anterior/posterior pattern specification;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35730-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BX22-1", "uniprot_id": "SALL4_MOUSE", "mass": 113110.0, "length": 1067, "protein_name": "Sal-like protein 4", "gene_name": "Sall4", "organism": "Mouse", "refseq_name": "sal-like protein 4 isoform a", "refseq_ac": "NP_780512", "gene_names_uniprotkb": "Sall4", "gene_names_refseq": "5730441M18Rik; C330011P20Rik; Sall4; Tex20", "protein_names_uniprotkb": "Sal-like protein 4; Zinc finger protein SALL4", "protein_names_refseq": "sal-like 4; sal-like protein 4 isoform a; sal-like protein 4; zinc finger protein SALL4", "tax_id": 10090, "disease": "Holt-Oram syndrome (Disease Ontology:DOID:0060468); Duane-radial ray syndrome (Disease Ontology:DOID:0060747); IVIC syndrome (Disease Ontology:DOID:0111381); otitis media (Disease Ontology:DOID:10754); Duane retraction syndrome (Disease Ontology:DOID:12557); ventricular septal defect (Disease Ontology:DOID:1657); endodermal sinus tumor (Disease Ontology:DOID:1911); ovarian germ cell cancer (Disease Ontology:DOID:2156); carcinoma (Disease Ontology:DOID:305); hepatoblastoma (Disease Ontology:DOID:687)", "pathway": " (mmu:99377); (R-MMU-8943724)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "12826753;16380715;16545361;16790473;16840789;17060609;19483677;21606357;21750661;22385656;22510880;30779550;36852467", "class_list": "", "function": "A positive and negative feed-forward circuit between Tbx5 and Sall4 ensures precise patterning of embryonic limb and heart and provides a unifying mechanism for heart/hand syndromes., [RefSeq, PubMed]; Cloning and expression analysis; prominent expression in the developing midbrain, branchial arches and the limbs suggests an important function of SALL4 during development of these structures, [RefSeq, PubMed]; Plzf antagonizes Sall4 function by displacing Sall4 from cognate chromatin to induce Sall1 expression, [RefSeq, PubMed]; Sall4 and Sall1 form heterodimers, and a truncated Sall1 caused mislocalization of Sall4 in the heterochromatin; thus, some symptoms of Townes-Brocks syndrome caused by SALL1 truncations could result from SALL4 inhibition., [RefSeq, PubMed]; Sall4 as an essential transcription factor required for the early development of inner cell mass-derived cell lineages, [RefSeq, PubMed]; This gene belongs to the spalt family of zinc finger transcription factors. In mouse, functions for this gene have been described in many embryonic developmental processes, including brain, heart, and limb development. In addition, this gene is an important pluripotency factor that is required for stem cell maintenance. Homozygous mutant mice display embryonic lethality, while conditional knock-out in embryonic germ cells results in failure to establish a robust stem cell population. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]; Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A2AV00;Q6S7E8;Q6S7E9;Q7TST6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0008134 transcription factor binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8BX22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1W9-1", "uniprot_id": "STK39_MOUSE", "mass": 60320.0, "length": 556, "protein_name": "STE20/SPS1-related proline-alanine-rich protein kinase", "gene_name": "Stk39", "organism": "Mouse", "refseq_name": "STE20/SPS1-related proline-alanine-rich protein kinase isoform 1", "refseq_ac": "NP_058562", "gene_names_uniprotkb": "Stk39; Spak", "gene_names_refseq": "DCHT; Gm50618; RF005; Rnl5; SPAK; Stk39", "protein_names_uniprotkb": "STE20/SPS1-related proline-alanine-rich protein kinase; 2.7.11.1; Serine/threonine-protein kinase 39; Ste-20-related kinase", "protein_names_refseq": "STE20/SPS1-related proline-alanine-rich protein kinase isoform 1; STE20/SPS1-related proline-alanine-rich protein kinase; Ste-20 related kinase; kidney-specific SPAK; serine/threonine kinase 39, STE20/SPS1 homolog; serine/threonine-protein kinase 39; ste-20-related kinase", "tax_id": 10090, "disease": "Gitelman syndrome (Disease Ontology:DOID:0050450); pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (mmu:53416)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10980603;12386165;14563843;15930150;16382158;16530727;17488636;19633012;20091762;20385770;21183079;21317537;21486947;21733846;21907141;23542070;24761002;25428506;26495903;33300544;33725478;34428180;37507081", "class_list": "", "function": "Cation chloride cotransporters interact with this protein, [RefSeq, PubMed]; Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16382158, PubMed:17488636, PubMed:19633012, PubMed:21486947). Specifically recognizes and binds proteins with a RFXV motif (PubMed:14563843). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:14563843, PubMed:16382158, PubMed:17488636, PubMed:19633012, PubMed:21486947). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (By similarity). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (By similarity). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:17488636, PubMed:19633012, PubMed:21486947). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (PubMed:21317537, PubMed:23542070). Phosphorylates RELT (PubMed:16530727)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; In vitro inhibits isoform 1-catalyzed phosphorylation, such as that of SLC12A1/NKCC2 or SLC12A3/NCC. Also inhibits in vitro OSR1 ability to phosphorylate SLC12A1/NKCC2., [UniProtKB, PubMed]; SPAK interacts with the cotransporter and serves as an intermediate in the response to cellular stress, [RefSeq, PubMed]; WNK4 interacting with SPAK, which in turn phosphorylates and activates NKCC1 and phosphorylates and deactivates KCC2, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G1JLS7;Q80W13", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0016020 membrane", "go_biological_process": "GO:0071476 cellular hypotonic response;GO:1901380 negative regulation of potassium ion transmembrane transport;GO:1990869 cellular response to chemokine;GO:0034763 negative regulation of transmembrane transport;GO:0030644 intracellular chloride ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q9Z1W9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZPJ0-1", "uniprot_id": "TEX2_MOUSE", "mass": 125226.0, "length": 1128, "protein_name": "Testis-expressed protein 2", "gene_name": "Tex2", "organism": "Mouse", "refseq_name": "testis-expressed protein 2", "refseq_ac": "NP_938034", "gene_names_uniprotkb": "Tex2; Kiaa1738", "gene_names_refseq": "4930568E07Rik; Def-5; Taz4; Tex2", "protein_names_uniprotkb": "Testis-expressed protein 2", "protein_names_refseq": "testis-expressed protein 2; testis-expressed sequence 2 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:21763); (R-MMU-8980692)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;17242355;21183079;21750661;30084848;31219806;34428180;35822049;36852467;39627609;40021952;40885482", "class_list": "", "function": "During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "B1ATR1", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q6ZPJ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62351-1", "uniprot_id": "TFR1_MOUSE", "mass": 85731.0, "length": 763, "protein_name": "Transferrin receptor protein 1", "gene_name": "Tfrc", "organism": "Mouse", "refseq_name": "transferrin receptor protein 1", "refseq_ac": "NP_035768", "gene_names_uniprotkb": "Tfrc; Trfr", "gene_names_refseq": "2610028K12Rik; CD71; E430033M20Rik; Mtvr1; TFR1; TFR; TR; Tfrc; Trfr; p90", "protein_names_uniprotkb": "Transferrin receptor protein 1; TR; TfR1; TfR; Trfr", "protein_names_refseq": "mammary tumor virus receptor 1; transferrin receptor protein 1", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); immunodeficiency 46 (Disease Ontology:DOID:0111948); prostate cancer (Disease Ontology:DOID:10283); iron deficiency anemia (Disease Ontology:DOID:11758); breast cancer (Disease Ontology:DOID:1612); duodenal ulcer (Disease Ontology:DOID:1724); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); breast carcinoma (Disease Ontology:DOID:3459); cervical adenocarcinoma (Disease Ontology:DOID:3702); nutrition disease (Disease Ontology:DOID:374); Weissenbacher-Zweymuller syndrome (Disease Ontology:DOID:4258); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); muscular atrophy (Disease Ontology:DOID:767); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:22042); (R-MMU-432722); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013407); (R-MMU-9013408); (R-MMU-9013423); (R-MMU-917977); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 16, "publication_count": 40, "publication_id_list": "10.1101/2023.09.13.557529;10192390;11180120;11465105;11801660;12682304;16075062;16393994;17322886;17947660;18299400;19131326;19349973;19892989;20173027;20484733;20485683;21183079;21750661;21952136;25428506;25428507;25605945;26495903;26642240;26740625;27802388;2984291;30084848;30779550;30899004;32152506;34428180;35820727;36583994;37507081;37828378;38625739;39627609;6092468", "class_list": "", "function": "Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Upon stimulation, positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity). Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production (PubMed:38625739)., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 16, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q61560", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051087 protein-folding chaperone binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005768 endosome;GO:0005769 early endosome", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0007166 cell surface receptor signaling pathway;GO:0007584 response to nutrient;GO:0010628 positive regulation of gene expression;GO:0031623 receptor internalization", "synthesized_glycan_count": 0, "hit_score": 5.2, "record_id": "Q62351-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YX1-1", "uniprot_id": "TENA_MOUSE", "mass": 231807.0, "length": 2110, "protein_name": "Tenascin", "gene_name": "Tnc", "organism": "Mouse", "refseq_name": "tenascin isoform 2 precursor", "refseq_ac": "NP_035737", "gene_names_uniprotkb": "Tnc; Hxb", "gene_names_refseq": "C130033P17Rik; Hxb; TN-C; TN; Ten; Tnc; cytotactin; tenascin-C", "protein_names_uniprotkb": "Tenascin; Hexabrachion; TN-C; TN; Tenascin-C", "protein_names_refseq": "hexabrachion; tenascin isoform 2 precursor", "tax_id": 10090, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); autosomal dominant nonsyndromic deafness 56 (Disease Ontology:DOID:0110581); asbestosis (Disease Ontology:DOID:10320); pleural tuberculosis (Disease Ontology:DOID:106); allergic conjunctivitis (Disease Ontology:DOID:11204); intracranial vasospasm (Disease Ontology:DOID:13100); lung cancer (Disease Ontology:DOID:1324); pulmonary sarcoidosis (Disease Ontology:DOID:13406); asthma (Disease Ontology:DOID:2841); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); pleural empyema (Disease Ontology:DOID:3798); cholangiocarcinoma (Disease Ontology:DOID:4947); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); extrinsic allergic alveolitis (Disease Ontology:DOID:841)", "pathway": " (mmu:21923); (R-MMU-216083); (R-MMU-3000178); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;14709716;16553788;16944957;1703162;1717349;21750661;22654117;28011936;30899004;31599954;33300544;34428180;37828378", "class_list": "glycogene", "function": "Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins ITGA8:ITGB1, ITGA9:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 11, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 9, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 9, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 131, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 17, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "Q64706;Q80YX2", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0001968 fibronectin binding;GO:0045545 syndecan binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0060638 mesenchymal-epithelial cell signaling;GO:0007155 cell adhesion;GO:0007162 negative regulation of cell adhesion;GO:0007528 neuromuscular junction development;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q80YX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UUI3-1", "uniprot_id": "THEM4_MOUSE", "mass": 26031.0, "length": 230, "protein_name": "Acyl-coenzyme A thioesterase THEM4", "gene_name": "Them4", "organism": "Mouse", "refseq_name": "acyl-coenzyme A thioesterase THEM4", "refseq_ac": "NP_083707", "gene_names_uniprotkb": "Them4; Ctmp", "gene_names_refseq": "2700077M13Rik; 4921507I02Rik; Them4", "protein_names_uniprotkb": "Acyl-coenzyme A thioesterase THEM4; 3.1.2.2; Acyl-CoA thioesterase THEM4; Carboxyl-terminal modulator protein; Thioesterase superfamily member 4", "protein_names_refseq": "acyl-CoA thioesterase THEM4; acyl-coenzyme A thioesterase THEM4; carboxyl-terminal modulator protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:75778); (R-MMU-1257604); (R-MMU-165158); (R-MMU-199418); (R-MMU-389357); (R-MMU-5218920); (R-MMU-77289)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "11598301;19421406;23576753;23806337;24670215;29945911;30850672;34428180;36652767;37507081", "class_list": "", "function": "Carboxyl-terminal modulator protein (CTMP) deficiency mitigates denervation-induced skeletal muscle atrophy., [RefSeq, PubMed]; Carboxyl-terminal modulator protein regulates Akt signaling during skeletal muscle atrophy in vitro and a mouse model of amyotrophic lateral sclerosis. Publication Status: Online-Only, [RefSeq, PubMed]; Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism (By similarity). Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity (PubMed:19421406)., [UniProtKB, PubMed, UniProtKB]; Increased cardiac expression of CTMP protects against cardiac hypertrophy by suppressing the protein kinase B signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that Akt is phosphorylated and translocated to nucleus after traumatic brain injury (TBI) to exert neuroprotective effects; however, CTMP is simultaneously triggered to inhibit the phosphorylation of Akt, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A3KPD5;Q8BYS9;Q8R234;Q9D5Y3", "ec_number_list": "3.1.2.2;3.1.2.-;3.1.2.22;2.7.11.1;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;3.1.1.4;3.1.1.5;3.5.2.6;2.3.1.16;2.3.1.9;3.1.2.14;2.3.1.65;2.7.10.2", "go_molecular_function": "GO:0052816 long-chain fatty acyl-CoA hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0032587 ruffle membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3UUI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCT9-1", "uniprot_id": "TESK2_MOUSE", "mass": 63470.0, "length": 570, "protein_name": "Dual specificity testis-specific protein kinase 2", "gene_name": "Tesk2", "organism": "Mouse", "refseq_name": "dual specificity testis-specific protein kinase 2", "refseq_ac": "NP_666263", "gene_names_uniprotkb": "Tesk2", "gene_names_refseq": "Tesk2", "protein_names_uniprotkb": "Dual specificity testis-specific protein kinase 2; 2.7.12.1; Testicular protein kinase 2", "protein_names_refseq": "dual specificity testis-specific protein kinase 2; testicular protein kinase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:230661)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;34428180", "class_list": "", "function": "Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.10.1;2.7.12.1;2.7.11.22;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.10.4;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007283 spermatogenesis;GO:0030036 actin cytoskeleton organization;GO:0048041 focal adhesion assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VCT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29758-1", "uniprot_id": "OAT_MOUSE", "mass": 48355.0, "length": 439, "protein_name": "Ornithine aminotransferase, mitochondrial", "gene_name": "Oat", "organism": "Mouse", "refseq_name": "ornithine aminotransferase, mitochondrial precursor", "refseq_ac": "NP_058674", "gene_names_uniprotkb": "Oat", "gene_names_refseq": "Oat; rhg", "protein_names_uniprotkb": "Ornithine aminotransferase, mitochondrial; 2.6.1.13; Ornithine--oxo-acid aminotransferase", "protein_names_refseq": "ornithine aminotransferase, mitochondrial precursor; ornithine aminotransferase, mitochondrial; ornithine--oxo-acid aminotransferase", "tax_id": 10090, "disease": "gyrate atrophy (Disease Ontology:DOID:1415); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:18242); (R-MMU-8964539)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "1286668;21750661;23576753;23806337;26740625;30084848;30779550;34428180;36991126;37453647;37507081;37828378;38397478;38413821", "class_list": "", "function": "CLPP-Null Eukaryotes with Excess Heme Biosynthesis Show Reduced L-arginine Levels, Probably via CLPX-Mediated OAT Activation. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate., [UniProtKB, UniProtKB]; Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer., [RefSeq, PubMed]; Role of lung ornithine aminotransferase in idiopathic pulmonary fibrosis: regulation of mitochondrial ROS generation and TGF-beta1 activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.6.1.13", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0004587 ornithine aminotransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0055129 L-proline biosynthetic process;GO:0010121 L-arginine catabolic process to proline via ornithine;GO:0019544 L-arginine catabolic process to L-glutamate", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P29758-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1X0-1", "uniprot_id": "NOL3_MOUSE", "mass": 24568.0, "length": 220, "protein_name": "Nucleolar protein 3", "gene_name": "Nol3", "organism": "Mouse", "refseq_name": "nucleolar protein 3", "refseq_ac": "NP_084428", "gene_names_uniprotkb": "Nol3; Arc", "gene_names_refseq": "ARC; B430311C09Rik; MYC; NOP; Nol3; Nop30", "protein_names_uniprotkb": "Nucleolar protein 3; Apoptosis repressor with CARD", "protein_names_refseq": "apoptosis repressor with CARD; nucleolar protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:78688)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15383280;16505176;22082675;24312627;24440909;34382577;36288343", "class_list": "", "function": "Apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:16505176, PubMed:24312627). Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (By similarity). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation (By similarity). Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner (By similarity). Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I (PubMed:24440909). Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia (PubMed:22082675). Inhibits too myoblast differentiation through caspase inhibition (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Loss of apoptosis repressor with caspase recruitment domain (ARC) worsens high fat diet-induced hyperglycemia in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0019900 kinase binding;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0051562 negative regulation of mitochondrial calcium ion concentration;GO:0002931 response to ischemia;GO:0043066 negative regulation of apoptotic process;GO:0051259 protein complex oligomerization;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D1X0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70548-1", "uniprot_id": "TELT_MOUSE", "mass": 19078.0, "length": 167, "protein_name": "Telethonin", "gene_name": "Tcap", "organism": "Mouse", "refseq_name": "telethonin", "refseq_ac": "NP_035670", "gene_names_uniprotkb": "Tcap", "gene_names_refseq": "Tcap", "protein_names_uniprotkb": "Telethonin; Titin cap protein", "protein_names_refseq": "telethonin; titin cap protein", "tax_id": 10090, "disease": "autosomal recessive limb-girdle muscular dystrophy type 2G (Disease Ontology:DOID:0110281); hypertrophic cardiomyopathy 25 (Disease Ontology:DOID:0110328)", "pathway": " (mmu:21393); (R-MMU-390522)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21183079;36574402;38569934;9804419", "class_list": "", "function": "Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk (By similarity)., [UniProtKB]; Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere., [RefSeq, PubMed]; The circadian E3 ligase FBXL21 regulates myoblast differentiation and sarcomere architecture via MYOZ1 ubiquitination and NFAT signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0030674 protein-macromolecule adaptor activity;GO:0044325 transmembrane transporter binding;GO:0008307 structural constituent of muscle;GO:0031432 titin binding", "go_cellular_component": "GO:0031674 I band;GO:0030018 Z disc;GO:1990733 titin-telethonin complex", "go_biological_process": "GO:0035995 detection of muscle stretch;GO:0003009 skeletal muscle contraction;GO:0030240 skeletal muscle thin filament assembly;GO:0003300 cardiac muscle hypertrophy;GO:0055003 cardiac myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O70548-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09838-2", "uniprot_id": "TDT_MOUSE", "mass": 58266.0, "length": 510, "protein_name": "DNA nucleotidylexotransferase", "gene_name": "Dntt", "organism": "Mouse", "refseq_name": "DNA nucleotidylexotransferase isoform 2", "refseq_ac": "NP_001036693", "gene_names_uniprotkb": "Dntt; Tdt", "gene_names_refseq": "Dntt; Tdt", "protein_names_uniprotkb": "DNA nucleotidylexotransferase; 2.7.7.31; 3.1.11.-; TDT; Terminal addition enzyme; Terminal deoxynucleotidyltransferase; Terminal transferase", "protein_names_refseq": "DNA nucleotidylexotransferase isoform 2; DNA nucleotidylexotransferase; terminal addition enzyme; terminal deoxynucleotidyl transferase", "tax_id": 10090, "disease": "acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:21673)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10878023;11136823;11823435;11938351;21183079;23856622;23968551;30084848;30779550;35354960;3755527;7556063;8464703", "class_list": "", "function": "3'-to-5' DNA exonuclease. Involved in the generation of diversity in the antigen-binding region of immunoglobulin heavy and light chains and T-cell receptors during B- and T-cell development. Acts on single-stranded and double-stranded DNA with 3' or 5' extensions, but not on double-stranded DNA with blunt ends. Attenuates not only isoform TDT-S-catalyzed N addition, but also P (palindromic) addition in coding joins (PubMed:11938351). Lacks terminal transferase activity (PubMed:11136823, PubMed:7556063)., [UniProtKB, PubMed, PubMed, PubMed]; Dntt expression reveals developmental hierarchy and lineage specification of hematopoietic progenitors., [RefSeq, PubMed]; Transferase that catalyzes the nontemplated addition of nucleoside triphosphate to coding ends during V(D)J recombination (N addition). Involved in the generation of diversity in the antigen-binding region of immunoglobulin heavy and light chains and T-cell receptors during B- and T-cell development. Does not act on double-stranded DNA with blunt ends., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99PD0;Q99PD1", "ec_number_list": "2.7.7.49;3.1.11.-;2.7.7.31;3.1.21.-;2.7.7.7;4.2.99.-;2.7.7.102;5.6.2.-;4.2.99.18", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0003912 DNA nucleotidylexotransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016363 nuclear matrix;GO:0000785 chromatin", "go_biological_process": "GO:0006259 DNA metabolic process;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0033198 response to ATP;GO:0006304 DNA modification", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P09838-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VD76-1", "uniprot_id": "TF2H3_MOUSE", "mass": 34244.0, "length": 309, "protein_name": "General transcription factor IIH subunit 3", "gene_name": "Gtf2h3", "organism": "Mouse", "refseq_name": "general transcription factor IIH subunit 3", "refseq_ac": "NP_852075", "gene_names_uniprotkb": "Gtf2h3", "gene_names_refseq": "34kDa; 5033417D07Rik; BTF2 p34; BTF2; C730029A10; D5Ertd679e; Gtf2h3; TFIIH", "protein_names_uniprotkb": "General transcription factor IIH subunit 3; BTF2 p34; Basic transcription factor 2 34 kDa subunit; General transcription factor IIH polypeptide 3; TFIIH basal transcription factor complex p34 subunit", "protein_names_refseq": "BTF2-p34; TFIIH basal transcription factor complex p34 subunit; basic transcription factor 2 34 kDa subunit; general transcription factor IIH subunit 3; general transcription factor IIH, polypeptide 3, 34kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:209357); (R-MMU-112382); (R-MMU-113418); (R-MMU-5696395); (R-MMU-5696400); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-72086); (R-MMU-73762); (R-MMU-73772); (R-MMU-73776); (R-MMU-73779); (R-MMU-73863); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-77075)", "pathway_count": 20, "publication_count": 6, "publication_id_list": "17952069;23562818;25340339;30068551;34418053;9230306", "class_list": "", "function": "Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription., [UniProtKB, UniProtKB]; Extensive molecular analyses unveiled that wild-type TFIIH cooperated in an ATP-dependent manner with PGC1-alpha as well as with the deacetylase SIRT1, thereby contributing to the PGC1-a deacetylation by SIRT1 Publication Status: Online-Only, [RefSeq, PubMed]; Molecular analyses performed on the mice brain tissue demonstrate that TFIIH is required for the stabilization of thyroid hormone receptors (TR) to their DNA-responsive elements., [RefSeq, PubMed]; Mutations in TFIIH causing trichothiodystrophy are responsible for defects in ribosomal RNA production and processing., [RefSeq, PubMed]; Using quantitative imaging of TFIIH in living mouse cells, we found that these molecules reduce the intracellular concentration of TFIIH and its transcriptional activity to levels similar to that observed in individuals with trichothiodystrophy owing to mutated TTD-A, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005675 transcription factor TFIIH holo complex;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VD76-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D494-1", "uniprot_id": "TERB2_MOUSE", "mass": 25030.0, "length": 218, "protein_name": "Telomere repeats-binding bouquet formation protein 2", "gene_name": "Terb2", "organism": "Mouse", "refseq_name": "telomere repeats-binding bouquet formation protein 2", "refseq_ac": "NP_083190", "gene_names_uniprotkb": "Terb2", "gene_names_refseq": "4933406J08Rik; Terb2", "protein_names_uniprotkb": "Telomere repeats-binding bouquet formation protein 2", "protein_names_refseq": "telomere repeats-binding bouquet formation protein 2", "tax_id": 10090, "disease": "spermatogenic failure 59 (Disease Ontology:DOID:0112357)", "pathway": " (mmu:74401)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26548954;30718482;32408858", "class_list": "", "function": "Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA., [UniProtKB, PubMed]; Study identified meiosis-specific telomere and inner nuclear membrane-binding proteins, telomere repeat-binding bouquet formation protein 2 (TERB2) and membrane-anchored junction protein (MAJIN), which form a complex with TERB1. Erratum:[Cell. 2018 May 3;173(4):1058. doi: 10.1016/j.cell.2018.04.025. PMID: 29727665], [RefSeq, PubMed]; The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back to the common ancestor of metazoans. Publication Status: Online-Only, [RefSeq, PubMed]; The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005637 nuclear inner membrane;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007130 synaptonemal complex assembly;GO:0070197 meiotic attachment of telomere to nuclear envelope;GO:0048477 oogenesis;GO:0007129 homologous chromosome pairing at meiosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D494-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DC40-1", "uniprot_id": "TELO2_MOUSE", "mass": 93313.0, "length": 840, "protein_name": "Telomere length regulation protein TEL2 homolog", "gene_name": "Telo2", "organism": "Mouse", "refseq_name": "telomere length regulation protein TEL2 homolog", "refseq_ac": "NP_001157133", "gene_names_uniprotkb": "Telo2; Kiaa0683", "gene_names_refseq": "1200003M09Rik; Tel2; Telo2; mKIAA0683", "protein_names_uniprotkb": "Telomere length regulation protein TEL2 homolog", "protein_names_refseq": "TEL2, telomere maintenance 2, homolog; telomere length regulation protein TEL2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:71718)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15345747;18160036;20801936;20864032;24657168;24794838;31323273;36288343", "class_list": "", "function": "IP7, formed by IP6K2, binds CK2 to enhance its phosphorylation of the Tti1/Tel2 complex, thereby stabilizing DNA-PKcs and ATM. This process stimulates p53 phosphorylation at serine 15 to activate the cell death program. Erratum:[Mol Cell. 2020 Aug 20;79(4):702. doi: 10.1016/j.molcel.2020.07.021. PMID: 32822581], [RefSeq, PubMed]; Identify Tel2 as a highly conserved regulator of the stability of PI3K-related protein kinases., [RefSeq, PubMed]; Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation (By similarity)., [UniProtKB]; The CK2 phospho-dependent interaction between TEL2 and the R2TP complex affects phosphatidylinositol 3-kinase-related kinase functions and is essential for mTOR and SMG1 stability in vivo., [RefSeq, PubMed]; Upregulating Tel2 expression increases mTOR-mediated cardiomyocyte survival and targeting Tel2 could be another therapeutic strategy against ischemic heart disease, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3J5;Q3UID7;Q3UP41;Q8BN03;Q8C1T3;Q91VQ3", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0019900 kinase binding;GO:0042162 telomeric DNA binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0016604 nuclear body", "go_biological_process": "GO:0051083 'de novo' cotranslational protein folding;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9DC40-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28574-1", "uniprot_id": "MAX_MOUSE", "mass": 18245.0, "length": 160, "protein_name": "Protein max", "gene_name": "Max", "organism": "Mouse", "refseq_name": "protein max isoform 1", "refseq_ac": "NP_032584", "gene_names_uniprotkb": "Max; Myn", "gene_names_refseq": "Max; bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8", "protein_names_uniprotkb": "Protein max; Myc-associated factor X; Myc-binding novel HLH/LZ protein; Protein myn", "protein_names_refseq": "myc-associated factor X; myc-binding novel HLH/LZ protein; protein max isoform 1; protein max; protein myn", "tax_id": 10090, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); lung small cell carcinoma (Disease Ontology:DOID:5409); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:17187); (R-MMU-8953750)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12391307;1840505;21750661;26495903;34857746;36180527;36484839;36852467;38433229;9680483", "class_list": "", "function": "Integrated analysis of mRNA-seq and miRNA-seq reveals the potential roles of Egr1, Rxra and Max in kidney stone disease. Publication Status: Online-Only, [RefSeq, PubMed]; MAX controls meiotic entry in sexually undifferentiated germ cells. Publication Status: Online-Only, [RefSeq, PubMed]; Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing. Publication Status: Online-Only, [RefSeq, PubMed]; SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. CpG methylation of the recognition site greatly inhibits DNA binding, suggesting that DNA methylation may regulate the MYC:MAX complex in vivo. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RS19;Q8C4Y1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030425 dendrite;GO:0016605 PML body;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P28574-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JI33-1", "uniprot_id": "NET4_MOUSE", "mass": 69867.0, "length": 628, "protein_name": "Netrin-4", "gene_name": "Ntn4", "organism": "Mouse", "refseq_name": "netrin-4 precursor", "refseq_ac": "NP_067295", "gene_names_uniprotkb": "Ntn4", "gene_names_refseq": "Ntn4", "protein_names_uniprotkb": "Netrin-4; Beta-netrin", "protein_names_refseq": "beta-netrin; netrin-4 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:57764); (R-MMU-373752)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10940631;11038171;17588941;18719102;21750661;33923095;35687692", "class_list": "", "function": "Anti-Inflammatory Role of Netrin-4 in Diabetic Retinopathy. Publication Status: Online-Only, [RefSeq, PubMed]; May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants., [UniProtKB, PubMed]; Netrin-4 is a component of basement membranes and is integrated into the laminin polymer via interactions with the laminin gamma1 andgamma3 short arms., [RefSeq, PubMed]; Netrin-4 significantly reduced pathological angiogenesis in Matrigel and laser-induced choroidal neovascularization models. Netrin-4, neogenin, and Unc5B receptor expression was up-regulated in choroidal neovessel EC after laser injury, [RefSeq, PubMed]; The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulating NTN4 expression., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QMT3", "ec_number_list": "", "go_molecular_function": "GO:0043237 laminin-1 binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005604 basement membrane;GO:0043256 laminin complex", "go_biological_process": "GO:0060668 regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling;GO:0016322 neuron remodeling;GO:0016477 cell migration;GO:0009887 animal organ morphogenesis;GO:0034446 substrate adhesion-dependent cell spreading", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JI33-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35239-1", "uniprot_id": "PTN9_MOUSE", "mass": 67970.0, "length": 593, "protein_name": "Tyrosine-protein phosphatase non-receptor type 9", "gene_name": "Ptpn9", "organism": "Mouse", "refseq_name": "tyrosine-protein phosphatase non-receptor type 9", "refseq_ac": "NP_062625", "gene_names_uniprotkb": "Ptpn9", "gene_names_refseq": "MEG2; Ptpn9", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 9; 3.1.3.48; PTPase MEG2; Protein-tyrosine phosphatase MEG2", "protein_names_refseq": "PTPase MEG2; Protein-tyrosine phosphatase, non-receptor type 9 (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2); protein-tyrosine phosphatase MEG2; tyrosine-protein phosphatase non-receptor type 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:56294)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16679294;21750661;27655914;30084848;30315478;33799458;34428180;38656553", "class_list": "", "function": "As a result, overexpression of PTP-MEG2 down-regulates NGF/TrkA signaling and blocks neurite outgrowth and differentiation, [RefSeq, PubMed]; Phloridzin Acts as an Inhibitor of Protein-Tyrosine Phosphatase MEG2 Relevant to Insulin Resistance. Publication Status: Online-Only, [RefSeq, PubMed]; Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus., [UniProtKB]; Role in the negative regulation of hepatic insulin signaling, [RefSeq, PubMed]; The binding of PKCepsilon and MEG2 to STAT3 regulates IL-6-mediated microglial hyperalgesia during inflammatory pain., [RefSeq, PubMed]; The heterozygous loss of Meg2 in mice is sufficient to cause intraocular pressure elevation and glaucomatous neurodegeneration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSK0", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0044306 neuron projection terminus", "go_biological_process": "GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0007165 signal transduction;GO:0010977 negative regulation of neuron projection development;GO:1903078 positive regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35239-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64249-1", "uniprot_id": "NR6A1_MOUSE", "mass": 55976.0, "length": 495, "protein_name": "Nuclear receptor subfamily 6 group A member 1", "gene_name": "Nr6a1", "organism": "Mouse", "refseq_name": "nuclear receptor subfamily 6 group A member 1 isoform 2", "refseq_ac": "NP_001153020", "gene_names_uniprotkb": "Nr6a1; Gcnf", "gene_names_refseq": "1700113M01Rik; Gcnf; NCNF; Nr6a1; RTR", "protein_names_uniprotkb": "Nuclear receptor subfamily 6 group A member 1; GCNF; Germ cell nuclear factor; RTR; Retinoid receptor-related testis-specific receptor; mGCNF", "protein_names_refseq": "germ cell nuclear factor; mGCNF; nuclear receptor subfamily 6 group A member 1 isoform 2; retinoid receptor-related testis-specific receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:14536); (R-MMU-383280)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11178239;11702949;12080054;12606326;21750661;27984042;34428180;35183538;40610405;7760852;7835709;7854358;9025060", "class_list": "", "function": "Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to the development of depression-like behaviors in mice., [RefSeq, PubMed]; Orphan nuclear receptor that binds to a response element containing the sequence 5'-TCAAGGTCA-3' (PubMed:11702949, PubMed:27984042, PubMed:7854358). Acts as a regulator of embryonic stem cell pluripotency by mediating repression of POU5F1/OCT4: binds to the DR0 element within the POU5F1/OCT4 promoter and inhibits POU5F1/OCT4 expression during embryonic stem cell differentiation (PubMed:11702949, PubMed:27984042). Required to restrict POU5F1/OCT4 expression to the germ cell lineage (PubMed:11702949). Involved in the regulation of gene expression in germ cell development during gametogenesis (PubMed:7854358)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AQL8;A2AQM1;Q687Z3", "ec_number_list": "", "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q64249-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHR9-1", "uniprot_id": "NRIP2_MOUSE", "mass": 29284.0, "length": 270, "protein_name": "Nuclear receptor-interacting protein 2", "gene_name": "Nrip2", "organism": "Mouse", "refseq_name": "nuclear receptor-interacting protein 2 isoform 1", "refseq_ac": "NP_001156330", "gene_names_uniprotkb": "Nrip2; Nix1", "gene_names_refseq": "NIX1; Nrip2", "protein_names_uniprotkb": "Nuclear receptor-interacting protein 2; Neuronal-interacting factor X 1", "protein_names_refseq": "neuronal interacting factor 1; neuronal-interacting factor X 1; nuclear receptor-interacting protein 2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:60345)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10860982;21750661;39927985", "class_list": "", "function": "Down-regulates transcriptional activation by nuclear receptors, such as NR1F2., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14BZ2;Q3U0V7;Q3UYH0", "ec_number_list": "", "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JHR9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61470-1", "uniprot_id": "CD37_MOUSE", "mass": 31852.0, "length": 281, "protein_name": "Leukocyte antigen CD37", "gene_name": "Cd37", "organism": "Mouse", "refseq_name": "leukocyte antigen CD37 isoform 3", "refseq_ac": "NP_031671", "gene_names_uniprotkb": "Cd37", "gene_names_refseq": "Cd37; Tspan26", "protein_names_uniprotkb": "Leukocyte antigen CD37", "protein_names_refseq": "leukocyte antigen CD37 isoform 3; leukocyte antigen CD37", "tax_id": 10090, "disease": "", "pathway": " (mmu:12493)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10891477;21750661;23150881;23420539;26495903;26566675;26784544;29187734;29551516;30185523;34428180;38625120;8845018", "class_list": "", "function": "CD37 may protect against IgA nephropathy by inhibition of the IL-6 pathway., [RefSeq, PubMed]; Proximity-Based Labeling Identifies MHC Class II and CD37 as B Cell Receptor-Proximal Proteins with Immunological Functions., [RefSeq, PubMed]; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (PubMed:10891477). Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B (By similarity). Plays an essential role for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT (PubMed:23150881). Also plays a role in the migration of dendritic cells and neutrophils to draining lymph nodes, as well as in their integrin-mediated adhesion (PubMed:23420539, PubMed:26566675). Negatively regulates IL-6 responses through direct interaction with SOCS3 thereby preventing constitutive IL-6 signaling (By similarity). Alternatively, inhibition of IL-6 signaling can also occur via interaction and stabilization of DECTIN1/CLEC7A at the cell membrane to inhibit its ability to promote the production of IL-6 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Tetraspanin CD37 controls CLEC-2 membrane organization and provides new molecular insights into the mechanisms underlying CLEC-2-dependent dendritic cell migration. Publication Status: Online-Only, [RefSeq, PubMed]; This study identifies CD37 as a tumor suppressor that directly protects against B cell lymphomagenesis, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001772 immunological synapse", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0042832 defense response to protozoan;GO:0050688 regulation of defense response to virus;GO:0002920 regulation of humoral immune response;GO:0002639 positive regulation of immunoglobulin production", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q61470-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80ZI6-1", "uniprot_id": "LRSM1_MOUSE", "mass": 83976.0, "length": 727, "protein_name": "E3 ubiquitin-protein ligase LRSAM1", "gene_name": "Lrsam1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase LRSAM1 isoform a", "refseq_ac": "NP_955006", "gene_names_uniprotkb": "Lrsam1", "gene_names_refseq": "Lrsam1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase LRSAM1; 2.3.2.27; Leucine-rich repeat and sterile alpha motif-containing protein 1; RING-type E3 ubiquitin transferase LRSAM1; Tsg101-associated ligase", "protein_names_refseq": "E3 ubiquitin-protein ligase LRSAM1 isoform a; E3 ubiquitin-protein ligase LRSAM1; RING-type E3 ubiquitin transferase LRSAM1; leucine-rich repeat and sterile alpha motif-containing protein 1; tsg101-associated ligase", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease axonal type 2P (Disease Ontology:DOID:0110169)", "pathway": " (mmu:227738); (R-MMU-983168)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15256501;21750661;22872234;23519028;25428506;25692136;31037734;34428180;35842440", "class_list": "", "function": "C698R mutation in Lrsam1 gene impairs nerve regeneration in a CMT2P mouse model. Publication Status: Online-Only, [RefSeq, PubMed]; Downregulation of miR-431-5p promoted proliferation of enteric neural crest cells via targeting LRSAM1, which provides an innovative and candidate target for treatment of Hirschsprung's disease, [RefSeq, PubMed]; E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (viral proteins) cargos (By similarity). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (By similarity). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (By similarity)., [UniProtKB, UniProtKB]; Lrsam1 mutant mice are more sensitive to challenge with acrylamide, a neurotoxic agent that causes axon degeneration, indicating that the axons in the mutant mice are indeed compromised., [RefSeq, PubMed]; TLR4/NF-kappaB-responsive microRNAs and their potential target genes: a mouse model of skeletal muscle ischemia-reperfusion injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.11.1;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0045806 negative regulation of endocytosis;GO:0006914 autophagy;GO:0000209 protein polyubiquitination;GO:0051865 protein autoubiquitination;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q80ZI6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V88-1", "uniprot_id": "NPNT_MOUSE", "mass": 61490.0, "length": 561, "protein_name": "Nephronectin", "gene_name": "Npnt", "organism": "Mouse", "refseq_name": "nephronectin isoform b precursor", "refseq_ac": "NP_001025007", "gene_names_uniprotkb": "Npnt; Neph1; Poem", "gene_names_refseq": "1110009H02Rik; Nctn; Npnt; POEM", "protein_names_uniprotkb": "Nephronectin; Preosteoblast EGF-like repeat protein with MAM domain", "protein_names_refseq": "nephronectin isoform b precursor; preosteoblast EGF-like repeat protein with MAM domain", "tax_id": 10090, "disease": "bilateral renal aplasia (Disease Ontology:DOID:0080200); membranous glomerulonephritis (Disease Ontology:DOID:10976); proteinuria (Disease Ontology:DOID:576)", "pathway": " (mmu:114249)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11470831;11546798;17537792;21750661;23357641;25428506;36719987;38246333", "class_list": "", "function": "Expression of Nephronectin in the Descemet's membrane of mouse corneas during development and adult homeostasis., [RefSeq, PubMed]; Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Nephronectin is required to maintain right lung lobar separation during embryonic development., [RefSeq, PubMed]; Results thus place nephronectin and alpha8beta1 integrin in a pathway that regulates Gdnf expression and is essential for kidney development, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 1, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 1, "secondary_ac_list": "Q6NV58;Q80VP6;Q91XL5;Q91ZD3;Q923T5", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane;GO:0031012 extracellular matrix;GO:0030485 smooth muscle contractile fiber;GO:0005604 basement membrane", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045987 positive regulation of smooth muscle contraction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q91V88-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A8Z1-1", "uniprot_id": "OSBL9_MOUSE", "mass": 83109.0, "length": 736, "protein_name": "Oxysterol-binding protein-related protein 9", "gene_name": "Osbpl9", "organism": "Mouse", "refseq_name": "oxysterol-binding protein-related protein 9 isoform b", "refseq_ac": "NP_775485", "gene_names_uniprotkb": "Osbpl9; Orp9", "gene_names_refseq": "2600011I06Rik; Orp-9; Osbpl9", "protein_names_uniprotkb": "Oxysterol-binding protein-related protein 9; ORP-9; OSBP-related protein 9", "protein_names_refseq": "OSBP-related protein 9; oxysterol-binding protein-related protein 9 isoform b; oxysterol-binding protein-related protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:100273); (R-MMU-192105)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17242355;19413330;21183079;21750661;31219806;34428180;36210013;37507081", "class_list": "", "function": "Includes data showing N-alpha terminal acetylation of the homologous human protein (OSBL9_HUMAN), where the N-terminal sequence is nASIMEGPLSK following cleavage of the initiating Met-1 derived from a downstream start codon in the transcript., [RefSeq, PubMed]; Interacts with OSBPL11 to function as lipid transfer proteins. Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A9Q8", "ec_number_list": "", "go_molecular_function": "GO:0032934 sterol binding;GO:0160270 phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0006649 phospholipid transfer to membrane;GO:0055091 phospholipid homeostasis;GO:0097212 lysosomal membrane organization;GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A2A8Z1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVA3-1", "uniprot_id": "BUB3_MOUSE", "mass": 36955.0, "length": 326, "protein_name": "Mitotic checkpoint protein BUB3", "gene_name": "Bub3", "organism": "Mouse", "refseq_name": "mitotic checkpoint protein BUB3 isoform a", "refseq_ac": "NP_001304279", "gene_names_uniprotkb": "Bub3", "gene_names_refseq": "Bub3", "protein_names_uniprotkb": "Mitotic checkpoint protein BUB3; WD repeat type I transmembrane protein A72.5", "protein_names_refseq": "WD repeat type I transmembrane protein A72.5; budding uninhibited by benzimidazoles 3 homolog; mitotic checkpoint protein BUB3 isoform a; mitotic checkpoint protein BUB3", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:12237); (R-MMU-141430); (R-MMU-141444); (R-MMU-174184); (R-MMU-176409); (R-MMU-179409); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 11, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10411903;12011073;19888327;21750661;27177335;31219806;33300544;34428180;36210013", "class_list": "", "function": "Cenpa, Cenpb, and Bub3, but not Cenpc, interacted with PARP-1, [RefSeq, PubMed]; Data show that Zfp207 binds to Bub3 to form a complex and maintains its protein level in oocytes, and that overexpression of Bub3 is able to partially rescue the occurrence of aneuploid eggs in Zfp207-depleted oocytes., [RefSeq, PubMed]; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1 (By similarity). Regulates chromosome segregation during oocyte meiosis., [UniProtKB, PubMed]; This gene encodes a component of the mitotic spindle assembly complex. The encoded protein is involved in the regulation of chromosome segregation during oocyte meiosis. Disruption of this gene results in the accumulation of mitotic errors and is lethal in the embryonic stage. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97397;Q6ZWM5", "ec_number_list": "", "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000776 kinetochore;GO:0033597 mitotic checkpoint complex;GO:1990298 bub1-bub3 complex;GO:0005634 nucleus", "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0051321 meiotic cell cycle;GO:0034501 protein localization to kinetochore", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9WVA3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UTQ8-1", "uniprot_id": "CDKL5_MOUSE", "mass": 105489.0, "length": 938, "protein_name": "Cyclin-dependent kinase-like 5", "gene_name": "Cdkl5", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase-like 5 isoform 3", "refseq_ac": "NP_001019795", "gene_names_uniprotkb": "Cdkl5", "gene_names_refseq": "Cdkl5; Stk9", "protein_names_uniprotkb": "Cyclin-dependent kinase-like 5; 2.7.11.22", "protein_names_refseq": "cyclin-dependent kinase-like 5 isoform 3; serine/threonine kinase 9", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 2 (Disease Ontology:DOID:0080467); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); intellectual disability (Disease Ontology:DOID:1059); Rett syndrome (Disease Ontology:DOID:1206)", "pathway": " (mmu:382253)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16935860;18701457;21183079;21750661;27840050;30084848;31219806;33300544;34428180;35820727", "class_list": "", "function": "CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail, [RefSeq, PubMed]; CDKL5 phosphorylation is required for its entrance into the nucleus whereas a portion of the COOH-terminal domain is responsible for a stable residency in this cellular compartment probably through protein-protein interactions, [RefSeq, PubMed]; Mediates phosphorylation of MECP2. May regulate ciliogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q05BK3;Q8BWI8", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0031267 small GTPase binding;GO:0016301 kinase activity;GO:0004693 cyclin-dependent protein serine/threonine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001764 neuron migration;GO:0034504 protein localization to nucleus;GO:0050804 modulation of chemical synaptic transmission;GO:0045773 positive regulation of axon extension;GO:0050775 positive regulation of dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q3UTQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VK1-1", "uniprot_id": "5MP1_MOUSE", "mass": 48063.0, "length": 419, "protein_name": "eIF5-mimic protein 1", "gene_name": "Bzw2", "organism": "Mouse", "refseq_name": "eIF5-mimic protein 1", "refseq_ac": "NP_080116", "gene_names_uniprotkb": "Bzw2; 5mp1", "gene_names_refseq": "1110001I24Rik; 5mp1; Bdm2; Bzw2; HSPC028", "protein_names_uniprotkb": "eIF5-mimic protein 1; Basic leucine zipper and W2 domain-containing protein 2", "protein_names_refseq": "basic leucine zipper and W2 domain-containing protein 2; brain development-related molecule 2; eIF5-mimic protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66912)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15345747;17660561;21183079;21750661;31599954;34428180;37955350", "class_list": "", "function": "BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification., [RefSeq, PubMed]; Transcripts highly enriched in ovary; gene identified as candidate female fertility factor., [RefSeq, PubMed]; Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (By similarity). Increases the accuracy of translation initiation by impeding EIF5-dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C-binding dependent manner (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D0N4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006446 regulation of translational initiation;GO:0006417 regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91VK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1L5-1", "uniprot_id": "CA2D3_MOUSE", "mass": 122778.0, "length": 1091, "protein_name": "Voltage-dependent calcium channel subunit alpha-2/delta-3", "gene_name": "Cacna2d3", "organism": "Mouse", "refseq_name": "voltage-dependent calcium channel subunit alpha-2/delta-3 precursor", "refseq_ac": "NP_033915", "gene_names_uniprotkb": "Cacna2d3", "gene_names_refseq": "Cacna2d3; Cacnad3; alapha2delta3", "protein_names_uniprotkb": "Voltage-dependent calcium channel subunit alpha-2/delta-3; Voltage-gated calcium channel subunit alpha-2/delta-3", "protein_names_refseq": "alpha 2 delta-3; voltage-dependent calcium channel alpha2/delta-3 transcript; voltage-dependent calcium channel subunit alpha-2/delta-3 precursor; voltage-dependent calcium channel subunit alpha-2/delta-3; voltage-gated calcium channel subunit alpha-2/delta-3", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); heart conduction disease (Disease Ontology:DOID:10273)", "pathway": " (mmu:12294); (R-MMU-112308)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10200414;11306709;11687876;21750661;30899004;33300544;9880589", "class_list": "", "function": "The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005245 voltage-gated calcium channel activity;GO:0005262 calcium channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005891 voltage-gated calcium channel complex;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0006816 calcium ion transport;GO:1990314 cellular response to insulin-like growth factor stimulus;GO:0099174 regulation of presynapse organization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9Z1L5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921B4-1", "uniprot_id": "NRIF2_MOUSE", "mass": 93244.0, "length": 824, "protein_name": "Neurotrophin receptor-interacting factor 2", "gene_name": "Nrif2; Zfp369", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nrif2; Zfp369; Zfp369", "gene_names_refseq": "", "protein_names_uniprotkb": "Neurotrophin receptor-interacting factor 2; Zinc finger protein 369", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:170936)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11750124;21750661;31599954", "class_list": "", "function": "Transcription regulator which may participate in NGFR/p75(NTR)-mediated apoptosis. Probably acts as a transcription repressor: specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJF0;Q8K1Y8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0005166 neurotrophin p75 receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q921B4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88803-1", "uniprot_id": "LECT2_MOUSE", "mass": 16405.0, "length": 151, "protein_name": "Leukocyte cell-derived chemotaxin-2", "gene_name": "Lect2", "organism": "Mouse", "refseq_name": "leukocyte cell-derived chemotaxin-2 precursor", "refseq_ac": "NP_034832", "gene_names_uniprotkb": "Lect2", "gene_names_refseq": "Lect2", "protein_names_uniprotkb": "Leukocyte cell-derived chemotaxin-2; ChM-II; Chondromodulin II; LECT-2", "protein_names_refseq": "LECT-2; chM-II; chondromodulin II; leukocyte cell-derived chemotaxin-2 precursor", "tax_id": 10090, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:16841)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10050029;20103838;21750661;35676290;36569272;36740832;38781447;39206203;9714793", "class_list": "", "function": "Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation., [UniProtKB, PubMed]; LECT2 Deletion Exacerbates Liver Steatosis and Macrophage Infiltration in a Male Mouse Model of LPS-mediated NASH., [RefSeq, PubMed]; LECT2 modulates dendritic cell function after Helicobacter pylori infection via the CD209a receptor., [RefSeq, PubMed]; Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET. Publication Status: Online-Only, [RefSeq, PubMed]; Liver infiltration of multiple immune cells during the process of acute liver injury and repair., [RefSeq, PubMed]; Role of LECT2 in exacerbating atopic dermatitis: insight from in vivo and in vitro models via NF-kappaB signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88804;Q3V287;Q8K181;Q9QWN3;Q9Z337", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol", "go_biological_process": "GO:0006935 chemotaxis;GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O88803-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61979-1", "uniprot_id": "NNAT_MOUSE", "mass": 9211.0, "length": 81, "protein_name": "Neuronatin", "gene_name": "Nnat", "organism": "Mouse", "refseq_name": "neuronatin isoform c", "refseq_ac": "NP_001278057", "gene_names_uniprotkb": "Nnat", "gene_names_refseq": "5730414I02Rik; Nnat; Peg5", "protein_names_uniprotkb": "Neuronatin", "protein_names_refseq": "neuronatin isoform c", "tax_id": 10090, "disease": "", "pathway": " (mmu:18111)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;23527188;7556909", "class_list": "", "function": "May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system., [UniProtKB]; Nnat expression in hypothalamus is regulated by short-term nutrient availability, but unaltered by diet-induced obesity or calorie restriction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q548Q0;Q61980;Q61981", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0032024 positive regulation of insulin secretion;GO:0007420 brain development;GO:0032880 regulation of protein localization;GO:0009749 response to glucose", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q61979-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2U4-1", "uniprot_id": "NTM1A_MOUSE", "mass": 25420.0, "length": 223, "protein_name": "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "gene_name": "Ntmt1", "organism": "Mouse", "refseq_name": "N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a", "refseq_ac": "NP_733480", "gene_names_uniprotkb": "Ntmt1; Mettl11a", "gene_names_refseq": "2610205E22Rik; Mettl11a; NTM1A; Ntmt1", "protein_names_uniprotkb": "N-terminal Xaa-Pro-Lys N-methyltransferase 1; 2.1.1.244; Alpha N-terminal protein methyltransferase 1A; Methyltransferase-like protein 11A; NTM1A; X-Pro-Lys N-terminal protein methyltransferase 1A", "protein_names_refseq": "N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a; X-Pro-Lys N-terminal protein methyltransferase 1A; alpha N-terminal protein methyltransferase 1A; methyltransferase like 11A; methyltransferase-like protein 11A", "tax_id": 10090, "disease": "", "pathway": " (mmu:66617)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;20668449;21750661", "class_list": "", "function": "Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif (PubMed:20668449). Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1) (By similarity). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1 (PubMed:20668449)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9884, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2APZ4", "ec_number_list": "2.1.1.244", "go_molecular_function": "GO:0071885 N-terminal protein N-methyltransferase activity;GO:0008276 protein methyltransferase activity;GO:0042054 histone methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0018012 N-terminal peptidyl-alanine trimethylation;GO:0018013 N-terminal peptidyl-glycine methylation;GO:0018016 N-terminal peptidyl-proline dimethylation;GO:0035572 N-terminal peptidyl-serine dimethylation;GO:0035573 N-terminal peptidyl-serine trimethylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R2U4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61881-1", "uniprot_id": "MCM7_MOUSE", "mass": 81211.0, "length": 719, "protein_name": "DNA replication licensing factor MCM7", "gene_name": "Mcm7", "organism": "Mouse", "refseq_name": "DNA replication licensing factor MCM7 isoform a", "refseq_ac": "NP_032594", "gene_names_uniprotkb": "Mcm7; Cdc47; MCM7; Mcmd7", "gene_names_refseq": "Mcm7; Mcmd7; mCDC47", "protein_names_uniprotkb": "DNA replication licensing factor MCM7; 3.6.4.12; CDC47 homolog", "protein_names_refseq": "CDC47 homolog; DNA replication licensing factor MCM7 isoform a; DNA replication licensing factor MCM7; mini chromosome maintenance deficient 7; minichromosome maintenance deficient 7", "tax_id": 10090, "disease": "pancreatic ductal carcinoma (Disease Ontology:DOID:3587); hepatocellular carcinoma (Disease Ontology:DOID:684); hyperthyroidism (Disease Ontology:DOID:7998)", "pathway": " (mmu:17220); (R-MMU-176187); (R-MMU-68867); (R-MMU-68949); (R-MMU-68962); (R-MMU-69052)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10567526;12207017;15240697;21750661;30084848;31219806;33590678;34203471;34428180;34887587;36210013;39627609;40021952;8566808", "class_list": "", "function": "Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Uncomplexed form does not show ATPase or DNA helicase (PubMed:12207017). Required for S-phase checkpoint activation upon UV-induced damage (By similarity)., [UniProtKB, UniProtKB, PubMed]; Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Role of subunits in DNA helicases activity, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;2.7.7.102;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;2.7.7.7;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;2.7.11.22;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.49;2.7.11.1;2.7.4.3;3.1.11.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0042555 MCM complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006271 DNA strand elongation involved in DNA replication;GO:0008283 cell population proliferation;GO:0071466 cellular response to xenobiotic stimulus;GO:0006260 DNA replication;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q61881-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1ARW8-1", "uniprot_id": "CA122_MOUSE", "mass": 11319.0, "length": 110, "protein_name": "Uncharacterized protein C1orf122 homolog", "gene_name": "1110065P20Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C1orf122 homolog isoform 1", "refseq_ac": "NP_001334125", "gene_names_uniprotkb": "1110065P20Rik", "gene_names_refseq": "1110065P20Rik; C530005M16Rik", "protein_names_uniprotkb": "Uncharacterized protein C1orf122 homolog", "protein_names_refseq": "uncharacterized protein C1orf122 homolog isoform 1; uncharacterized protein C1orf122 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68920)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1ARW8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VIJ8-1", "uniprot_id": "NPRL3_MOUSE", "mass": 63618.0, "length": 569, "protein_name": "GATOR1 complex protein NPRL3", "gene_name": "Nprl3", "organism": "Mouse", "refseq_name": "GATOR1 complex protein NPRL3 isoform 1", "refseq_ac": "NP_001271288", "gene_names_uniprotkb": "Nprl3; Mare", "gene_names_refseq": "Aag; CGTHBA; HS-26; HS-40; Mare; Nprl3; Phg; Prox1; m(alpha)RE", "protein_names_uniprotkb": "GATOR1 complex protein NPRL3; Nitrogen permease regulator 3-like protein", "protein_names_refseq": "-14; GATOR complex protein NPRL3; GATOR1 complex protein NPRL3 isoform 1; GATOR1 complex protein NPRL3; alpha globin regulatory element containing; alpha-globin regulatory element-containing gene protein; nitrogen permease regulator 3-like protein; proximal locus to the hemoglobin alpha chain complex", "tax_id": 10090, "disease": "familial focal epilepsy with variable foci 3 (Disease Ontology:DOID:0081423)", "pathway": " (mmu:17168); (R-MMU-9639288)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11157800;18299400;20173027;21750661;21952136;22538705;25428506;25428507;30084848;32152506;33649389;34203471;34428180;34965576;35136953;35820727;36210013;37828378", "class_list": "", "function": "As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Dorsal telencephalon-specific Nprl2- and Nprl3-knockout mice: novel mouse models for GATORopathy., [RefSeq, PubMed]; NPRL3 loss alters neuronal morphology, mTOR localization, cortical lamination and seizure threshold., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:1990130 GATOR1 complex;GO:0005764 lysosome", "go_biological_process": "GO:0048738 cardiac muscle tissue development;GO:0010508 positive regulation of autophagy;GO:0003281 ventricular septum development;GO:0060021 roof of mouth development;GO:0035909 aorta morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8VIJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70206-1", "uniprot_id": "PLXA1_MOUSE", "mass": 211099.0, "length": 1894, "protein_name": "Plexin-A1", "gene_name": "Plxna1", "organism": "Mouse", "refseq_name": "plexin-A1 precursor", "refseq_ac": "NP_032907", "gene_names_uniprotkb": "Plxna1; Kiaa4053", "gene_names_refseq": "2600013D04Rik; NOV; PlexA1; Plxn1; Plxna1; mKIAA4053", "protein_names_uniprotkb": "Plexin-A1; Plex 1; Plexin-1", "protein_names_refseq": "plex 1; plexin-1; plexin-A1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:18844); (R-MMU-399954); (R-MMU-399955); (R-MMU-399956); (R-MMU-416700); (R-MMU-9696273)", "pathway_count": 6, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10520994;10781943;12559962;14685275;14977921;16286926;16715077;19349973;21750661;25428506;30899004;31219806;31599954;33300544;34428180;36210013;37344233;38331165;8806667", "class_list": "", "function": "Chronic stress promotes gastric cancer progression via the adrenoceptor beta 2/PlexinA1 pathway., [RefSeq, PubMed]; Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis (PubMed:16715077)., [UniProtKB, PubMed, PubMed, PubMed]; Semaphorin-6D and Plexin-A1 Act in a Non-Cell-Autonomous Manner to Position and Target Retinal Ganglion Cell Axons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 9, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 12, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 12, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 6, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 16, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "B2RQP7;Q5DTR0", "ec_number_list": "", "go_molecular_function": "GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0002116 semaphorin receptor complex;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0097485 neuron projection guidance;GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0071526 semaphorin-plexin signaling pathway;GO:0014910 regulation of smooth muscle cell migration;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "P70206-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70207-1", "uniprot_id": "PLXA2_MOUSE", "mass": 211535.0, "length": 1894, "protein_name": "Plexin-A2", "gene_name": "Plxna2", "organism": "Mouse", "refseq_name": "plexin-A2 precursor", "refseq_ac": "NP_032908", "gene_names_uniprotkb": "Plxna2; Kiaa0463", "gene_names_refseq": "2810428A13Rik; OCT; PlexA2; Plxn2; Plxna2; mKIAA0463", "protein_names_uniprotkb": "Plexin-A2; Plex 2; Plexin-2", "protein_names_refseq": "plex 2; plexin-2; plexin-A2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:18845); (R-MMU-399954); (R-MMU-399955); (R-MMU-399956)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10520994;10781943;20877282;20881961;21750661;22645316;25428506;30084848;30899004;33300544;34428180;35820727;8806646", "class_list": "", "function": "Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 10, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 11, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 11, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q6NVE6;Q6PHN4;Q80TZ7;Q8R1I4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0071526 semaphorin-plexin signaling pathway;GO:0007416 synapse assembly;GO:0021915 neural tube development;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "P70207-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0M6-1", "uniprot_id": "AGRE5_MOUSE", "mass": 90413.0, "length": 818, "protein_name": "Adhesion G protein-coupled receptor E5", "gene_name": "Adgre5", "organism": "Mouse", "refseq_name": "adhesion G protein-coupled receptor E5 isoform 2 precursor", "refseq_ac": "NP_001156501", "gene_names_uniprotkb": "Adgre5; Cd97", "gene_names_refseq": "Adgre5; Cd97; TM7LN1", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor E5; Leukocyte antigen CD97", "protein_names_refseq": "CD97 antigen; EGF-TM7 receptor; adhesion G protein-coupled receptor E5 isoform 2 precursor; leukocyte antigen CD97", "tax_id": 10090, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); vibratory urticaria (Disease Ontology:DOID:1554); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (mmu:26364); (R-MMU-373080); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10540231;10744645;14707087;18299400;19349973;19656770;20173027;21183079;21750661;21913724;26495903;26740625;28935714;34428180;35143305;35984892;37828378;37978243", "class_list": "", "function": "CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation., [RefSeq, PubMed]; CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells., [RefSeq, PubMed]; Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q923A1;Q9CVI5;Q9JLQ8", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding;GO:0035374 chondroitin sulfate binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009897 external side of plasma membrane;GO:0031256 leading edge membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q9Z0M6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V1T4-1", "uniprot_id": "P3H1_MOUSE", "mass": 83651.0, "length": 739, "protein_name": "Prolyl 3-hydroxylase 1", "gene_name": "P3h1", "organism": "Mouse", "refseq_name": "prolyl 3-hydroxylase 1 isoform 3", "refseq_ac": "NP_001035874", "gene_names_uniprotkb": "P3h1; Gros1; Lepre1", "gene_names_refseq": "2410024C15Rik; Gros1; Lepre1; P3h1", "protein_names_uniprotkb": "Prolyl 3-hydroxylase 1; 1.14.11.7; Growth suppressor 1; Leprecan-1; Leucine- and proline-enriched proteoglycan 1", "protein_names_refseq": "growth suppressor 1; leprecan 1; leucine- and proline-enriched proteoglycan 1; prolyl 3-hydroxylase 1 isoform 3", "tax_id": 10090, "disease": "osteogenesis imperfecta type 8 (Disease Ontology:DOID:0110336)", "pathway": " (mmu:56401); (R-MMU-1650814)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10951563;21750661;24465224;25428506;26808442;31219806;34428180;35820727", "class_list": "glycogene", "function": "Has prolyl 3-hydroxylase activity and catalyzes the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in pro-collagen chains, a critical step for the formation of mature collagen trimers (By similarity). May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts (By similarity)., [UniProtKB, UniProtKB]; P3H1 deficiency leads to decreased deposition of extracellular matrix by osteoblasts and increased incorporation of mineral into the matrix., [RefSeq, PubMed]; We generated knock-in mice carrying a single amino acid substitution in the catalytic site of P3h1 (Lepre1(H662A) ). This substitution abolished P3h1 activity but retained ability to form a complex with Crtap and thus the collagen chaperone Erratum:[PLoS Genet. 2014 Jun;10(6):e1004473], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 37, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2A7Q4;A6PW85;Q3TWX8;Q8BSV2;Q8CFL3;Q9CWK5;Q9QZT6;Q9QZT7", "ec_number_list": "5.2.1.8;1.14.11.7", "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0019797 procollagen-proline 3-dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005604 basement membrane", "go_biological_process": "GO:1901874 negative regulation of post-translational protein modification;GO:0010976 positive regulation of neuron projection development;GO:0030199 collagen fibril organization;GO:0050821 protein stabilization;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q3V1T4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TT38-1", "uniprot_id": "ILRUN_MOUSE", "mass": 32082.0, "length": 291, "protein_name": "Protein ILRUN", "gene_name": "Ilrun", "organism": "Mouse", "refseq_name": "protein ILRUN isoform 1", "refseq_ac": "NP_001028451", "gene_names_uniprotkb": "Ilrun; D17Wsu92e", "gene_names_refseq": "C030010A15; D17Wsu92e; Ilrun", "protein_names_uniprotkb": "Protein ILRUN", "protein_names_refseq": "protein ILRUN isoform 1; protein ILRUN; uncharacterized protein C6orf106 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:224647)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;30084848;32912065;34428180;35861973", "class_list": "", "function": "ILRUN Promotes Atherosclerosis Through Lipid-Dependent and Lipid-Independent Factors., [RefSeq, PubMed]; ILRUN, a Human Plasma Lipid GWAS Locus, Regulates Lipoprotein Metabolism in Mice., [RefSeq, PubMed]; Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF. Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RT11", "ec_number_list": "", "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0045087 innate immune response;GO:1900181 negative regulation of protein localization to nucleus;GO:0016236 macroautophagy;GO:0032720 negative regulation of tumor necrosis factor production;GO:0050687 negative regulation of defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3TT38-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSJ6-1", "uniprot_id": "LATS2_MOUSE", "mass": 115472.0, "length": 1042, "protein_name": "Serine/threonine-protein kinase LATS2", "gene_name": "Lats2", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase LATS2 isoform 1", "refseq_ac": "NP_056586", "gene_names_uniprotkb": "Lats2", "gene_names_refseq": "4932411G09Rik; Lats2", "protein_names_uniprotkb": "Serine/threonine-protein kinase LATS2; 2.7.11.1; Kinase phosphorylated during mitosis protein; Large tumor suppressor homolog 2; Serine/threonine-protein kinase kpm", "protein_names_refseq": "kinase phosphorylated during mitosis protein; large tumor suppressor homolog 2; serine/threonine-protein kinase LATS2 isoform 1; serine/threonine-protein kinase LATS2; serine/threonine-protein kinase kpm", "tax_id": 10090, "disease": "benign neoplasm (Disease Ontology:DOID:0060072); neurodegenerative disease (Disease Ontology:DOID:1289); cancer (Disease Ontology:DOID:162); kidney cancer (Disease Ontology:DOID:263); carcinoma (Disease Ontology:DOID:305); peripheral nerve sheath neoplasm (Disease Ontology:DOID:3193); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:50523); (R-MMU-2028269)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10673337;15343267;17478426;21750661;25428506;31219806;34428180;39173637", "class_list": "", "function": "Lats2 plays an essential mitotic role in coordinating accurate cytokinesis completion, governing the stabilization of other mitotic regulators, [RefSeq, PubMed]; Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (By similarity). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (By similarity). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:15343267). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (By similarity). Negative regulator of the androgen receptor (By similarity). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (By similarity). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (By similarity). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8CDJ4;Q9JMI3", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0034451 centriolar satellite", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TSJ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNH6-1", "uniprot_id": "NPHP3_MOUSE", "mass": 150289.0, "length": 1325, "protein_name": "Nephrocystin-3", "gene_name": "Nphp3", "organism": "Mouse", "refseq_name": "nephrocystin-3 isoform a", "refseq_ac": "NP_082997", "gene_names_uniprotkb": "Nphp3; Kiaa2000", "gene_names_refseq": "3632410F03Rik; C230078J01; D330020E01Rik; Nphp3; pcy", "protein_names_uniprotkb": "Nephrocystin-3", "protein_names_refseq": "nephrocystin-3 isoform a; nephrocystin-3", "tax_id": 10090, "disease": "renal-hepatic-pancreatic dysplasia (Disease Ontology:DOID:0060259); Meckel syndrome 7 (Disease Ontology:DOID:0070121); nephronophthisis 3 (Disease Ontology:DOID:0111114); hypertension (Disease Ontology:DOID:10763); nephronophthisis (Disease Ontology:DOID:12712); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (mmu:74025); (R-MMU-5624138)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12872122;18371931;21750661;30779550", "class_list": "", "function": "Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6RHB4;E9Q5X1;E9QN29;Q69Z39;Q8C798;Q8C7Z3;Q9D6D1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0097546 ciliary base;GO:0097543 ciliary inversin compartment;GO:0097542 ciliary tip", "go_biological_process": "GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway;GO:0060993 kidney morphogenesis;GO:0048496 maintenance of animal organ identity;GO:0006629 lipid metabolic process;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TNH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08665-1", "uniprot_id": "SEM3A_MOUSE", "mass": 88813.0, "length": 772, "protein_name": "Semaphorin-3A", "gene_name": "Sema3a", "organism": "Mouse", "refseq_name": "semaphorin-3A precursor", "refseq_ac": "NP_001230001", "gene_names_uniprotkb": "Sema3a; SemD; Semad", "gene_names_refseq": "Hsema-I; SEMA1; SemD; Sema3a; Semad; coll-1", "protein_names_uniprotkb": "Semaphorin-3A; Sema D; Sema III; Semaphorin III; Semaphorin-D", "protein_names_refseq": "collapsin-1; sema D; sema III; semaphorin III; semaphorin-3A precursor; semaphorin-3A; semaphorin-D", "tax_id": 10090, "disease": "hypogonadotropic hypogonadism 16 with or without anosmia (Disease Ontology:DOID:0090080)", "pathway": " (mmu:20346); (R-MMU-399954); (R-MMU-399955); (R-MMU-399956)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12925274;15239958;21750661;25428506;30084848;30779550;31599954;34428180;37828378;7748561;7748562;9331345", "class_list": "", "function": "Plays a role in growth cones guidance. May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally. Involved in the development of the olfactory system and in neuronal control of puberty (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QK85;Q5BL08;Q62180;Q62215", "ec_number_list": "", "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:2000020 positive regulation of male gonad development;GO:0010633 negative regulation of epithelial cell migration;GO:0097490 sympathetic neuron projection extension;GO:0097491 sympathetic neuron projection guidance;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "O08665-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BLF2-1", "uniprot_id": "CDKL3_MOUSE", "mass": 67739.0, "length": 595, "protein_name": "Cyclin-dependent kinase-like 3", "gene_name": "Cdkl3", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase-like 3 isoform 1", "refseq_ac": "NP_001160125", "gene_names_uniprotkb": "Cdkl3", "gene_names_refseq": "B230379H01Rik; Cdkl3", "protein_names_uniprotkb": "Cyclin-dependent kinase-like 3; 2.7.11.22", "protein_names_refseq": "cyclin-dependent kinase-like 3 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:213084)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20347982;21750661;25270654;25605945;34428180", "class_list": "", "function": "CDKL3 is involved in neuronal morphogenesis during development., [RefSeq, PubMed]; Results indicated that CDKL3 may be involved in proliferation of cells surrounding the brain ventricle where neuronal progenitor cells are enriched during the late embryo st, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ACR7;A2ACR8;A2ACR9;A2ACS0;A2ACS1;Q5M6W2;Q8BKR2;Q8BL49;Q8BLN9;Q8BVE0;Q8K134", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity;GO:0001784 phosphotyrosine residue binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0050775 positive regulation of dendrite morphogenesis;GO:0097484 dendrite extension;GO:0030517 negative regulation of axon extension;GO:0072584 caveolin-mediated endocytosis;GO:2000641 regulation of early endosome to late endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BLF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CII2-1", "uniprot_id": "CD123_MOUSE", "mass": 38816.0, "length": 336, "protein_name": "Translation initiation factor eIF2 assembly protein", "gene_name": "Cdc123", "organism": "Mouse", "refseq_name": "translation initiation factor eIF2 assembly protein isoform 1", "refseq_ac": "NP_598598", "gene_names_uniprotkb": "Cdc123", "gene_names_refseq": "Cdc123; G431001I09Rik", "protein_names_uniprotkb": "Translation initiation factor eIF2 assembly protein; Cell division cycle protein 123 homolog", "protein_names_refseq": "cell division cycle 123 homolog; cell division cycle protein 123 homolog; translation initiation factor eIF2 assembly protein isoform 1; translation initiation factor eIF2 assembly protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:98828)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "ATP-dependent protein-folding chaperone for the eIF2 complex (By similarity). Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; ATP-dependent protein-folding chaperone for the eIF2 complex. Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTR0;Q8VE51", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:1905143 eukaryotic translation initiation factor 2 complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CII2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60954-1", "uniprot_id": "NOL4_MOUSE", "mass": 53479.0, "length": 483, "protein_name": "Nucleolar protein 4", "gene_name": "Nol4", "organism": "Mouse", "refseq_name": "nucleolar protein 4 isoform 1", "refseq_ac": "NP_001154955", "gene_names_uniprotkb": "Nol4; Gm1262", "gene_names_refseq": "1700013J13Rik; 4930568N03Rik; Gm1262; Nol4", "protein_names_uniprotkb": "Nucleolar protein 4", "protein_names_refseq": "nucleolar protein 4 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:319211)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25366156", "class_list": "", "function": "These findings suggest that transactivation activities of Mlr1 and Mlr2 are differentially regulated by splicing variants of NOL4, which are expressed in a tissue-selective manner., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P60954-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BWW4-1", "uniprot_id": "LARP4_MOUSE", "mass": 79762.0, "length": 719, "protein_name": "La-related protein 4", "gene_name": "Larp4", "organism": "Mouse", "refseq_name": "la-related protein 4 isoform 1", "refseq_ac": "NP_001019697", "gene_names_uniprotkb": "Larp4", "gene_names_refseq": "DXErtd793e; DXErtd793; Larp4", "protein_names_uniprotkb": "La-related protein 4; La ribonucleoprotein domain family member 4", "protein_names_refseq": "La ribonucleoprotein domain family, member 4; la-related protein 4 isoform 1; la-related protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:207214)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "21183079;21750661;25153642;25428506;26644407;28135057;28528544;31219806;32735645;32782141;34887587;36852467;40021952;40885482", "class_list": "", "function": "Mouse LARP4 is regulated by TNF-alpha in a TTP-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]; RNA binding protein that binds to the poly-A tract of mRNA molecules. Associates with the 40S ribosomal subunit and with polysomes. Plays a role in the regulation of mRNA translation. Essential for proper regulation of cell morphology and cytoskeletal organization., [UniProtKB, UniProtKB]; Transcriptome-wide stability analysis uncovers LARP4-mediated NFkappaB1 mRNA stabilization during T cell activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "G3X9Q6;Q3UR69", "ec_number_list": "", "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding", "go_cellular_component": "GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0010608 post-transcriptional regulation of gene expression;GO:0007010 cytoskeleton organization;GO:0006412 translation;GO:0045727 positive regulation of translation;GO:0022604 regulation of cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8BWW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVJ3-1", "uniprot_id": "CBPQ_MOUSE", "mass": 51813.0, "length": 470, "protein_name": "Carboxypeptidase Q", "gene_name": "Cpq", "organism": "Mouse", "refseq_name": "carboxypeptidase Q precursor", "refseq_ac": "NP_061225", "gene_names_uniprotkb": "Cpq; Hls2; Pgcp", "gene_names_refseq": "1190003P12Rik; 2610034C17Rik; Cpq; Hls2; Lal-1; Pgcp", "protein_names_uniprotkb": "Carboxypeptidase Q; 3.4.17.-; Hematopoietic lineage switch 2; Plasma glutamate carboxypeptidase", "protein_names_refseq": "carboxypeptidase Q precursor; hematopoietic lineage switch 2; plasma glutamate carboxypeptidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:54381)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21750661;26495903;26740625;30084848;30899004;31219806;34428180;35820727;37507081", "class_list": "", "function": "Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O70216;Q3U8N9", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0004180 carboxypeptidase activity;GO:0070573 metallodipeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005764 lysosome", "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process;GO:0042246 tissue regeneration;GO:0006590 thyroid hormone generation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9WVJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920N2-1", "uniprot_id": "BPL1_MOUSE", "mass": 78516.0, "length": 722, "protein_name": "Biotin--protein ligase", "gene_name": "Hlcs", "organism": "Mouse", "refseq_name": "biotin--protein ligase isoform 2", "refseq_ac": "NP_631884", "gene_names_uniprotkb": "Hlcs", "gene_names_refseq": "410I21.SP6; D16Jhu34; Hlcs", "protein_names_uniprotkb": "Biotin--protein ligase; 6.3.4.-; Biotin apo-protein ligase; HCS; Holocarboxylase synthetase", "protein_names_refseq": "biotin apo-protein ligase; biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase; biotin--protein ligase isoform 2; biotin--protein ligase", "tax_id": 10090, "disease": "holocarboxylase synthetase deficiency (Disease Ontology:DOID:859)", "pathway": " (mmu:110948); (R-MMU-196780)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.4.1.2;6.4.1.1;6.4.1.4;6.4.1.3;6.3.4.-;6.3.4.10;6.3.4.11;6.3.4.15;6.3.4.9", "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0009374 biotin binding;GO:0004077 biotin--[biotin carboxyl-carrier protein] ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016363 nuclear matrix;GO:0000785 chromatin", "go_biological_process": "GO:0043687 post-translational protein modification;GO:0006768 biotin metabolic process;GO:0070781 response to biotin", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q920N2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C5V8-1", "uniprot_id": "CC187_MOUSE", "mass": 104957.0, "length": 958, "protein_name": "Coiled-coil domain-containing protein 187", "gene_name": "Ccdc187", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 187 isoform 3", "refseq_ac": "NP_808509", "gene_names_uniprotkb": "Ccdc187", "gene_names_refseq": "4932418E24Rik; Ccdc187", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 187", "protein_names_refseq": "coiled-coil domain-containing protein 187 isoform 3; coiled-coil domain-containing protein 187", "tax_id": 10090, "disease": "", "pathway": " (mmu:329366); (R-MMU-9013106)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome", "go_biological_process": "GO:0034453 microtubule anchoring", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C5V8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQH7-1", "uniprot_id": "LRP10_MOUSE", "mass": 76461.0, "length": 713, "protein_name": "Low-density lipoprotein receptor-related protein 10", "gene_name": "Lrp10", "organism": "Mouse", "refseq_name": "low-density lipoprotein receptor-related protein 10 precursor", "refseq_ac": "NP_075369", "gene_names_uniprotkb": "Lrp10; Lrp9", "gene_names_refseq": "Lrp10; Lrp9", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 10; LRP-10", "protein_names_refseq": "LRP-10; low-density lipoprotein receptor-related protein 10 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:65107); (R-MMU-975634)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;11123907;16075062;16393994;18250455;18461348;19497050;21750661;26495903;26740625;27802388;28011936;28935714;30084848;31219806;32152506;34428180;35984892;36210013;37828378", "class_list": "", "function": "Data show that Calnuc is involved in LRP9 endosomal sorting to prevent the delivery of LRP9 to lysosomes., [RefSeq, PubMed]; Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver., [UniProtKB, PubMed]; These results suggest that LRP9 cycles between the trans-Golgi network, endosomes and the plasma membrane through a GGA dependent-trafficking mechanism., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 2, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNT0;Q7TS95;Q921T0;Q9EPE8", "ec_number_list": "", "go_molecular_function": "GO:0005041 low-density lipoprotein particle receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0016020 membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006869 lipid transport;GO:0006897 endocytosis;GO:0048839 inner ear development", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q7TQH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CC96-1", "uniprot_id": "BNIP5_MOUSE", "mass": 72970.0, "length": 669, "protein_name": "Protein BNIP5", "gene_name": "Bnip5", "organism": "Mouse", "refseq_name": "protein BNIP5", "refseq_ac": "NP_766038", "gene_names_uniprotkb": "Bnip5; 4930539E08Rik", "gene_names_refseq": "4930539E08Rik; 9130014G02; Bnip5", "protein_names_uniprotkb": "Protein BNIP5", "protein_names_refseq": "protein BNIP5; uncharacterized protein C6orf222 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:207819)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30059200", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2KF61;Q148X2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CC96-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESF4-1", "uniprot_id": "LFG1_MOUSE", "mass": 38408.0, "length": 345, "protein_name": "Protein lifeguard 1", "gene_name": "Grina", "organism": "Mouse", "refseq_name": "protein lifeguard 1", "refseq_ac": "NP_075657", "gene_names_uniprotkb": "Grina; Lag; Lfg1; Nmdara1", "gene_names_refseq": "1110025J15Rik; Grina; Lag; Tmbim3", "protein_names_uniprotkb": "Protein lifeguard 1; Glutamate [NMDA] receptor-associated protein 1; NMDA receptor glutamate-binding subunit", "protein_names_refseq": "NMDA receptor glutamate-binding subunit; glutamate [NMDA] receptor-associated protein 1; protein lifeguard 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66168)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19784873;21614515;21750661;31219806;31683519;34428180", "class_list": "", "function": "GRINA/TMBIM3 plays a crucial role in post-ischemic unfolded protein response (UPR). Publication Status: Online-Only, [RefSeq, PubMed]; In this study, the authors show that TMBIM3 is expressed in the brain including high levels in the hippocampus., [RefSeq, PubMed]; Potential apoptotic regulator., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CI25", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0043524 negative regulation of neuron apoptotic process;GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0032469 endoplasmic reticulum calcium ion homeostasis;GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ESF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VE28-1", "uniprot_id": "NKD2_MOUSE", "mass": 51501.0, "length": 461, "protein_name": "Protein naked cuticle homolog 2", "gene_name": "Nkd2", "organism": "Mouse", "refseq_name": "protein naked cuticle homolog 2 isoform b", "refseq_ac": "NP_001334464", "gene_names_uniprotkb": "Nkd2", "gene_names_refseq": "2210403L10Rik; Nkd2; mNkd2", "protein_names_uniprotkb": "Protein naked cuticle homolog 2; Naked-2; mNkd2", "protein_names_refseq": "naked cuticle 1 homolog; naked cuticle 2 homolog; naked-2; protein naked cuticle homolog 2 isoform b; protein naked cuticle homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72293)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11356022;15064403;15511637;15546883;17094106;17362910;17438140;21750661", "class_list": "", "function": "Cell autonomous antagonist of the canonical Wnt signaling pathway., [UniProtKB, UniProtKB]; Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells (By similarity)., [UniProtKB]; Mouse naked cuticle 2 (mNkd2) is a direct transcriptional target of Hoxc8 in vivo., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TYU5;Q3UM34;Q8C4J8;Q91Y45;Q9D7U9", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019838 growth factor binding;GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0071944 cell periphery", "go_biological_process": "GO:0048210 Golgi vesicle fusion to target membrane;GO:0072659 protein localization to plasma membrane;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0010954 positive regulation of protein processing;GO:1903078 positive regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VE28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70353-1", "uniprot_id": "NFYC_MOUSE", "mass": 37254.0, "length": 335, "protein_name": "Nuclear transcription factor Y subunit gamma", "gene_name": "Nfyc", "organism": "Mouse", "refseq_name": "nuclear transcription factor Y subunit gamma isoform 1", "refseq_ac": "NP_001041633", "gene_names_uniprotkb": "Nfyc", "gene_names_refseq": "Nfyc", "protein_names_uniprotkb": "Nuclear transcription factor Y subunit gamma; CAAT box DNA-binding protein subunit C; NF-YC; Nuclear transcription factor Y subunit C", "protein_names_refseq": "CAAT box DNA-binding protein subunit C; nuclear transcription factor Y subunit C; nuclear transcription factor Y subunit gamma isoform 1; nuclear transcription factor Y subunit gamma", "tax_id": 10090, "disease": "", "pathway": " (mmu:18046)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;40997131;8910521;9287329", "class_list": "", "function": "Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35088;Q6GU21", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0032993 protein-DNA complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70353-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9B4-1", "uniprot_id": "LRMDA_MOUSE", "mass": 25989.0, "length": 229, "protein_name": "Leucine-rich melanocyte differentiation-associated protein", "gene_name": "Lrmda", "organism": "Mouse", "refseq_name": "leucine-rich melanocyte differentiation-associated protein", "refseq_ac": "NP_082551", "gene_names_uniprotkb": "Lrmda; 1700112E06Rik", "gene_names_refseq": "1700112E06Rik; 2700009F18Rik; Lrmda", "protein_names_uniprotkb": "Leucine-rich melanocyte differentiation-associated protein", "protein_names_refseq": "leucine-rich melanocyte differentiation-associated protein; leucine-rich repeat-containing protein C10orf11 homolog", "tax_id": 10090, "disease": "oculocutaneous albinism type VII (Disease Ontology:DOID:0070100)", "pathway": " (mmu:76633)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;36261399", "class_list": "", "function": "Required for melanocyte differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca[2+] -LRMDA Axis in Myeloid Cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0030318 melanocyte differentiation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D9B4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06909-1", "uniprot_id": "CFAH_MOUSE", "mass": 139138.0, "length": 1234, "protein_name": "Complement factor H", "gene_name": "Cfh", "organism": "Mouse", "refseq_name": "complement factor H precursor", "refseq_ac": "NP_034018", "gene_names_uniprotkb": "Cfh; Hf1", "gene_names_refseq": "Cfh; Mud-1; NOM; Sas-1; Sas1", "protein_names_uniprotkb": "Complement factor H; Protein beta-1-H", "protein_names_refseq": "complement factor H precursor; complement factor H related protein 3A4/5G4; protein beta-1-H", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); basal laminar drusen (Disease Ontology:DOID:0060746); lupus nephritis (Disease Ontology:DOID:0080162); atypical hemolytic-uremic syndrome (Disease Ontology:DOID:0080301); COVID-19 (Disease Ontology:DOID:0080600); age related macular degeneration 4 (Disease Ontology:DOID:0110017); membranous glomerulonephritis (Disease Ontology:DOID:10976); sarcoidosis (Disease Ontology:DOID:11335); panuveitis (Disease Ontology:DOID:12030); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); posterior uveitis (Disease Ontology:DOID:12574); cardiovascular system disease (Disease Ontology:DOID:1287); obstructive jaundice (Disease Ontology:DOID:13603); anterior uveitis (Disease Ontology:DOID:1407); glaucoma (Disease Ontology:DOID:1686); squamous cell carcinoma (Disease Ontology:DOID:1749); nephrosis (Disease Ontology:DOID:2527); retinal drusen (Disease Ontology:DOID:2569); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); brain infarction (Disease Ontology:DOID:3454); macular degeneration (Disease Ontology:DOID:4448); retinal detachment (Disease Ontology:DOID:5327); proteinuria (Disease Ontology:DOID:576); amphetamine abuse (Disease Ontology:DOID:670); retinal degeneration (Disease Ontology:DOID:8466); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:12628); (R-MMU-977606)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;16944957;17242355;17330941;20571061;21183079;2136885;21750661;23133374;2533512;25428506;26495903;26740625;28011936;2940596;30084848;30107932;34428180;39627609;40997131", "class_list": "", "function": "Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 28, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZK3", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0001851 complement component C3b binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0035886 vascular associated smooth muscle cell differentiation;GO:0002434 immune complex clearance;GO:0001525 angiogenesis;GO:0006508 proteolysis;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P06909-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64691-1", "uniprot_id": "CAN3_MOUSE", "mass": 94242.0, "length": 821, "protein_name": "Calpain-3", "gene_name": "Capn3", "organism": "Mouse", "refseq_name": "calpain-3 isoform c", "refseq_ac": "NP_001171270", "gene_names_uniprotkb": "Capn3", "gene_names_refseq": "Capa-3; Capa3; Capn3; Lp82; p94", "protein_names_uniprotkb": "Calpain-3; 3.4.22.54; CANP 3; Calcium-activated neutral proteinase 3; Calpain L3; Calpain p94; Muscle-specific calcium-activated neutral protease 3", "protein_names_refseq": "CANP 3; calcium-activated neutral proteinase 3; calpain L3; calpain-3 isoform c; muscle-specific calcium-activated neutral protease 3; skeletal muscle specific calpain p94", "tax_id": 10090, "disease": "autosomal dominant limb-girdle muscular dystrophy (Disease Ontology:DOID:0110273); autosomal recessive limb-girdle muscular dystrophy type 2A (Disease Ontology:DOID:0110275); hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); intellectual disability (Disease Ontology:DOID:1059); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hereditary spastic paraplegia (Disease Ontology:DOID:2476); hepatocellular carcinoma (Disease Ontology:DOID:684); muscular dystrophy (Disease Ontology:DOID:9884); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12335); (R-MMU-1474228)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;35820727;36999564;39031532;8661728", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-410'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53., [UniProtKB, UniProtKB]; Loss of Calpain 3 dysregulates store-operated calcium entry and its exercise response in mice., [RefSeq, PubMed]; Missense mutation of c.635 T > C in CAPN3 impairs muscle injury repair in a Limb-Girdel Muscular Dystropy Model., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AVV3;Q9WUC5", "ec_number_list": "3.4.22.53;3.4.22.-;3.4.22.52;3.4.22.54", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1990091 sodium-dependent self proteolysis;GO:0006508 proteolysis;GO:0043066 negative regulation of apoptotic process;GO:0051592 response to calcium ion;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q64691-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1F9-1", "uniprot_id": "LCTL_MOUSE", "mass": 64826.0, "length": 566, "protein_name": "Lactase-like protein", "gene_name": "Lctl", "organism": "Mouse", "refseq_name": "lactase-like protein precursor", "refseq_ac": "NP_665834", "gene_names_uniprotkb": "Lctl; Klph", "gene_names_refseq": "E130104I05Rik; KLPH; Lctl", "protein_names_uniprotkb": "Lactase-like protein; Klotho/lactase-phlorizin hydrolase-related protein", "protein_names_refseq": "Klotho-LPH related; klotho/lactase-phlorizin hydrolase-related protein; lactase-like protein precursor; lactase-like protein", "tax_id": 10090, "disease": "kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:235435)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12084582;21750661;29425878", "class_list": "glycogene;glycosylhydrolase", "function": "Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Results describe a novel mouse gene klph that encodes a novel mammalian family 1 glycosidase-like protein., [RefSeq, PubMed]; These results suggest that KLPH is required for lens-specific expression of Clic5 and that Clic5 has an important role in the machinery that controls lens fiber cell extension and organization., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 46, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPR1;Q8K2M9", "ec_number_list": "", "go_molecular_function": "GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005903 brush border;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0007601 visual perception;GO:0002089 lens morphogenesis in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K1F9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4K1-1", "uniprot_id": "CETN4_MOUSE", "mass": 19200.0, "length": 168, "protein_name": "Centrin-4", "gene_name": "Cetn4", "organism": "Mouse", "refseq_name": "centrin-4", "refseq_ac": "NP_665824", "gene_names_uniprotkb": "Cetn4; Cen4", "gene_names_refseq": "Cetn4", "protein_names_uniprotkb": "Centrin-4; Centrin4", "protein_names_refseq": "centrin-4; centrin4", "tax_id": 10090, "disease": "", "pathway": " (mmu:207175)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12802058;15347651;17971504;18269917;21750661", "class_list": "", "function": "Binding of Cen2 and Cen4 to Gbetagamma of non-visual G-proteins regulates G-proteins involved in centrosome and basal body functions, [RefSeq, PubMed]; Ca(2+)-binding protein that may be involved in basal body assembly or in a subsequent step of ciliogenesis., [UniProtKB, PubMed]; Cetn4 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PYP9;E9Q074;J3KMS3;Q3TLH1;Q5SUE1;Q8BIC4", "ec_number_list": "", "go_molecular_function": "GO:0031683 G-protein beta/gamma-subunit complex binding;GO:0032795 heterotrimeric G-protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization;GO:0007099 centriole replication", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K4K1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51491-1", "uniprot_id": "OPSB_MOUSE", "mass": 38922.0, "length": 346, "protein_name": "Short-wave-sensitive opsin 1", "gene_name": "Opn1sw", "organism": "Mouse", "refseq_name": "short-wave-sensitive opsin 1", "refseq_ac": "NP_031564", "gene_names_uniprotkb": "Opn1sw; Bcp", "gene_names_refseq": "Bcp; Opn1sw", "protein_names_uniprotkb": "Short-wave-sensitive opsin 1; BOP; Blue cone photoreceptor pigment; Blue-sensitive opsin; S opsin; Short wavelength-sensitive cone opsin", "protein_names_refseq": "BOP; S opsin; SWS opsin; UV cone pigment; blue cone opsin; blue cone photoreceptor pigment; blue cone pigment; blue opsin; blue visual pigment protein; blue-sensitive opsin; blue/UV opsin; short wavelength sensitive opsin; short wavelength-sensitive cone opsin; short-wave-sensitive opsin 1", "tax_id": 10090, "disease": "blue color blindness (Disease Ontology:DOID:11661)", "pathway": " (mmu:12057); (R-MMU-2187335); (R-MMU-418594); (R-MMU-419771)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "11055434;21219924;21750661;25416279;31219806;8088841", "class_list": "", "function": "G protein-coupled photoreceptor that selectively activates G(i) proteins in response to short-wavelength (blue-violet) light, thereby decreasing intracellular cAMP levels. Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade (By similarity). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of cone photoreceptor function (PubMed:21219924, PubMed:25416279). Involved in ensuring the correct abundance and localization of retinal membrane proteins (PubMed:25416279). Mediates visual perception of blue light (By similarity). May contribute to increased spectral sensitivity under dim light conditions (PubMed:11055434). Is not UV-sensitive (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors. Involved in ensuring correct abundance and localization of retinal membrane proteins. May increase spectral sensitivity in dim light., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q548Z8", "ec_number_list": "", "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity;GO:0004930 G protein-coupled receptor activity;GO:0009881 photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043195 terminal bouton;GO:0048471 perinuclear region of cytoplasm;GO:0044297 cell body;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071492 cellular response to UV-A", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P51491-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHG2-1", "uniprot_id": "CZIB_MOUSE", "mass": 18020.0, "length": 160, "protein_name": "CXXC motif containing zinc binding protein", "gene_name": "Czib", "organism": "Mouse", "refseq_name": "CXXC motif containing zinc binding protein isoform 2", "refseq_ac": "NP_001334089", "gene_names_uniprotkb": "Czib; 0610037L13Rik", "gene_names_refseq": "0610037L13Rik; 1110008H16Rik; Czib", "protein_names_uniprotkb": "CXXC motif containing zinc binding protein; UPF0587 protein C1orf123 homolog", "protein_names_refseq": "CXXC motif containing zinc binding protein isoform 2; UPF0587 protein C1orf123 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:74098)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A8E3;A2A8E5;Q8C7D6;Q9D1H2;Q9DCH5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BHG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJ04-1", "uniprot_id": "B4GT4_MOUSE", "mass": 39700.0, "length": 344, "protein_name": "Beta-1,4-galactosyltransferase 4", "gene_name": "B4galt4", "organism": "Mouse", "refseq_name": "beta-1,4-galactosyltransferase 4", "refseq_ac": "NP_001272722", "gene_names_uniprotkb": "B4galt4", "gene_names_refseq": "9130402O08Rik; B4galt-IV; B4galt4; b4Gal-T4; beta4Gal-T4; beta4GalT-IV", "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase 4; 2.4.1.-; 2.4.1.275; 2.4.1.90; Beta-1,4-GalTase 4; Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; Beta4Gal-T4; Lactotriaosylceramide beta-1,4-galactosyltransferase; N-acetyllactosamine synthase; Nal synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4; b4Gal-T4", "protein_names_refseq": "N-acetyllactosamine synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4; beta-1,4-GalTase 4; beta-1,4-galactosyltransferase 4; beta-1,4-galactosyltransferase IV; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; lactotriaosylceramide beta-1,4-galactosyltransferase; nal synthase", "tax_id": 10090, "disease": "", "pathway": " (mmu:56375); (R-MMU-2022854); (R-MMU-975577)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;34428180;36210013;9597550", "class_list": "glycogene;glycosyltransferase", "function": "Galactose (Gal) transferase involved in the synthesis of terminal N-acetyllactosamine (LacNac) unit present on glycan chains of glycoproteins and glycosphingolipids. Catalyzes the transfer of Gal residue via a beta1->4 linkage from UDP-Gal to the non-reducing terminal N-acetyl glucosamine 6-O-sulfate (6-O-sulfoGlcNAc) in the linearly growing chain of both N- and O-linked keratan sulfate proteoglycans. Cooperates with B3GNT7 N-acetyl glucosamine transferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono-and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer. Transfers Gal residue via a beta1->4 linkage to terminal 6-O-sulfoGlcNAc within the LacNac unit of core 2 O-glycans forming 6-sulfo-sialyl-Lewis X (sLex). May contribute to the generation of sLex epitope on mucin-type glycoproteins that serve as ligands for SELL/L-selectin, a major regulator of leukocyte migration. In the biosynthesis pathway of neolacto-series glycosphingolipids, transfers Gal residue via a beta1->4 linkage to terminal GlcNAc of a lactotriaosylceramide (Lc3Cer) acceptor to form a neolactotetraosylceramide. Efficiently galactosylates both non-sulfated and 6-O-sulfated terminal GlcNAc moities on G0 complex-type N-glycans., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BR54;Q9QY12", "ec_number_list": "2.4.1.-;2.4.1.275;2.4.1.22;2.4.1.38;2.4.1.90;2.4.1.274", "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0046872 metal ion binding;GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0003945 N-acetyllactosamine synthase activity;GO:0035250 UDP-galactosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0018146 keratan sulfate proteoglycan biosynthetic process;GO:0001572 lactosylceramide biosynthetic process", "synthesized_glycan_count": 2205, "hit_score": 0.5, "record_id": "Q9JJ04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JL18-1", "uniprot_id": "BACE2_MOUSE", "mass": 55800.0, "length": 514, "protein_name": "Beta-secretase 2", "gene_name": "Bace2", "organism": "Mouse", "refseq_name": "beta-secretase 2 preproprotein", "refseq_ac": "NP_062390", "gene_names_uniprotkb": "Bace2", "gene_names_refseq": "1110059C24Rik; AEPLC; ALP56; ARP1; ASP1; ASP21; BAE2; Bace2; CDA13; CEAP1; DRAP", "protein_names_uniprotkb": "Beta-secretase 2; 3.4.23.45; ASP1; Asp 1; Aspartyl protease 1; Beta-site APP cleaving enzyme 2; Beta-site amyloid precursor protein cleaving enzyme 2; Memapsin-1; Membrane-associated aspartic protease 1; Theta-secretase", "protein_names_refseq": "aspartyl protease 1; beta-secretase 2 preproprotein; beta-secretase 2; beta-site amyloid precursor protein cleaving enzyme 2; memapsin-1; membrane-associated aspartic protease 1; theta-secretase", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (mmu:56175)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10683441;15987683;17307738;18322192;21750661;21907142;23754390;25428506", "class_list": "", "function": "BACE1 and BACE2 may act as alternative alpha-secretase-like proteases in proteolytic processing of IL-1R2 and APP, [RefSeq, PubMed]; Data show that BACE1 knockout mice display a complex phenotype, and a combined deficiency of BACE2 and BACE1 enhanced the bace1-/- lethality., [RefSeq, PubMed]; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells., [UniProtKB, UniProtKB]; This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein undergoes proteolytic processing to generate an active endopeptidase enzyme. This transmembrane protease catalyzes the proteolysis of amyloid precursor protein to produce amyloid beta peptide. Mice lacking the encoded product exhibit increased pancreatic beta cell mass and improved glucose tolerance due to increased insulin secretion. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNS7;Q8C5E9;Q8C793;Q9R1P7", "ec_number_list": "", "go_molecular_function": "GO:0008233 peptidase activity;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0016485 protein processing;GO:0050435 amyloid-beta metabolic process;GO:0042593 glucose homeostasis;GO:0042985 negative regulation of amyloid precursor protein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JL18-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61205-1", "uniprot_id": "PA1B3_MOUSE", "mass": 25853.0, "length": 232, "protein_name": "Platelet-activating factor acetylhydrolase IB subunit alpha1", "gene_name": "Pafah1b3", "organism": "Mouse", "refseq_name": "platelet-activating factor acetylhydrolase IB subunit alpha1 isoform a", "refseq_ac": "NP_032802", "gene_names_uniprotkb": "Pafah1b3; Pafahg", "gene_names_refseq": "Pafah1b3; Pafahg; mus[g]", "protein_names_uniprotkb": "Platelet-activating factor acetylhydrolase IB subunit alpha1; 3.1.1.47; PAF acetylhydrolase 29 kDa subunit; PAF-AH 29 kDa subunit; PAF-AH subunit gamma; PAFAH subunit gamma", "protein_names_refseq": "PAF acetylhydrolase 29 kDa subunit; PAF-AH 29 kDa subunit; PAF-AH alpha1; PAF-AH gamma; PAF-AH subunit gamma; PAFAH subunit gamma; platelet-activating factor acetylhydrolase IB subunit alpha1 isoform a; platelet-activating factor acetylhydrolase IB subunit alpha1; platelet-activating factor acetylhydrolase IB subunit gamma", "tax_id": 10090, "disease": "", "pathway": " (mmu:18476); (R-MMU-6811436)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12775763;17330141;21750661;23386199;29853524;39627609;8954729", "class_list": "", "function": "Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In vivo RNAi screening identifies Pafah1b3 as a target for combination therapy with TKIs in BCR-ABL1(+) BCP-ALL., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.1.1;3.1.1.47;3.1.1.5;2.3.1.43;3.1.2.2;3.1.1.4;2.3.1.149;3.1.1.32", "go_molecular_function": "GO:0047179 platelet-activating factor acetyltransferase activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q61205-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4PJX1-1", "uniprot_id": "ODR4_MOUSE", "mass": 49998.0, "length": 447, "protein_name": "Protein odr-4 homolog", "gene_name": "Odr4", "organism": "Mouse", "refseq_name": "protein odr-4 homolog isoform 2", "refseq_ac": "NP_001070705", "gene_names_uniprotkb": "Odr4; BC003331", "gene_names_refseq": "1810053E15Rik; Odr4; odr-4", "protein_names_uniprotkb": "Protein odr-4 homolog; mODR-4", "protein_names_refseq": "mODR-4; olfactory specific odr-4; protein odr-4 homolog isoform 2; protein odr-4 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:226499)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15718105;21750661;25428506;30084848;34428180", "class_list": "", "function": "May play a role in the trafficking of a subset of G protein coupled receptors., [UniProtKB, UniProtKB]; May play a role in the trafficking of a subset of G-protein coupled receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U8Y3;Q99J66", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q4PJX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAQ4-1", "uniprot_id": "CB081_MOUSE", "mass": 65778.0, "length": 598, "protein_name": "Uncharacterized protein C2orf81 homolog", "gene_name": "1700003E16Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C2orf81 homolog", "refseq_ac": "NP_082224", "gene_names_uniprotkb": "1700003E16Rik", "gene_names_refseq": "1700003E16Rik", "protein_names_uniprotkb": "Uncharacterized protein C2orf81 homolog", "protein_names_refseq": "uncharacterized protein C2orf81 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:71837)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17971504;21750661;25428506", "class_list": "", "function": "1700003E16Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0JNU0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DAQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFV4-1", "uniprot_id": "NRN1_MOUSE", "mass": 15353.0, "length": 142, "protein_name": "Neuritin", "gene_name": "Nrn1", "organism": "Mouse", "refseq_name": "neuritin isoform 1 precursor", "refseq_ac": "NP_705757", "gene_names_uniprotkb": "Nrn1; Cpg15", "gene_names_refseq": "0710008J23Rik; Cpg15; Nrn1; Nrn", "protein_names_uniprotkb": "Neuritin; Candidate plasticity gene 15 protein", "protein_names_refseq": "candidate plasticity gene 15 protein; candidate plasticity-related gene 15; neuritin isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:68404); (R-MMU-163125)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14664806;16010668;16081067;16452087;21750661;22632720;34428180", "class_list": "", "function": "Cpg15 is an immediate-early gene induced by Ca(2+) influx through NMDA receptors and L-type voltage-sensitive calcium channels. It requires convergent activation of the CaM kinase and MAP kinase pathways., [RefSeq, PubMed]; Data show that neuritin expression is well correlated to the maturation of hepatocytes and can be a useful tool to define the differentiation stage of hepatocytes., [RefSeq, PubMed]; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells., [UniProtKB]; Regulation of cpg15 expression during single whisker experience in the barrel cortex of adult mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSR9", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0032281 AMPA glutamate receptor complex;GO:0098793 presynapse", "go_biological_process": "GO:0007399 nervous system development;GO:0007409 axonogenesis;GO:1990138 neuron projection extension;GO:0090128 regulation of synapse maturation;GO:0099171 presynaptic modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CFV4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56974-1", "uniprot_id": "NRG2_MOUSE", "mass": 82213.0, "length": 756, "protein_name": "Pro-neuregulin-2, membrane-bound isoform", "gene_name": "Nrg2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nrg2", "gene_names_refseq": "", "protein_names_uniprotkb": "Pro-neuregulin-2, membrane-bound isoform; DON-1; Divergent of neuregulin 1; Pro-NRG2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:100042150); (R-MMU-1227986); (R-MMU-1236394); (R-MMU-1250196); (R-MMU-1250342); (R-MMU-1250347); (R-MMU-1257604); (R-MMU-1306955); (R-MMU-1358803); (R-MMU-1963640); (R-MMU-1963642); (R-MMU-5673001); (R-MMU-6785631); (R-MMU-6811558); (R-MMU-8847993); (R-MMU-8863795)", "pathway_count": 16, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17114649;21750661;30899004;34428180;9168115;9199335", "class_list": "", "function": "Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0048018 receptor ligand activity;GO:0043125 ErbB-3 class receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005654 nucleoplasm", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007399 nervous system development;GO:0035556 intracellular signal transduction;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0051963 regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P56974-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZX1-1", "uniprot_id": "C209A_MOUSE", "mass": 27149.0, "length": 238, "protein_name": "CD209 antigen-like protein A", "gene_name": "Cd209a", "organism": "Mouse", "refseq_name": "CD209 antigen-like protein A", "refseq_ac": "NP_573501", "gene_names_uniprotkb": "Cd209a; Cire", "gene_names_refseq": "CD209; CDSIGN; CIRE; Cd209a; DC-SIGN1; DC-SIGN; Dcsign; SIGN-R1; SIGNR5", "protein_names_uniprotkb": "CD209 antigen-like protein A; DC-SIGN; Dendritic cell-specific ICAM-3-grabbing non-integrin", "protein_names_refseq": "CD209 antigen-like protein A; dendritic cell-specific ICAM-3-grabbing non-integrin", "tax_id": 10090, "disease": "extrapulmonary tuberculosis (Disease Ontology:DOID:0050598); rheumatic heart disease (Disease Ontology:DOID:0050827); Coronavirus infectious disease (Disease Ontology:DOID:0080599); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); dengue disease (Disease Ontology:DOID:12205); dengue hemorrhagic fever (Disease Ontology:DOID:12206); aspergillosis (Disease Ontology:DOID:13564); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); tuberculosis (Disease Ontology:DOID:399); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:170786); (R-MMU-5621575); (R-MMU-8851680)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "11581173;11684292;12351402;12456590;21750661;30335674;31358982;32424104;34428180;36740832", "class_list": "glycogene", "function": "DC-SIGN-specific mAb are channeled into the MHC class II presentation pathway, [RefSeq, PubMed]; Isolation of a murine homologue of DC-SIGN that is identical to the previously reported murine homologue mSIGNR1; expressed in marginal zone macrophages, [RefSeq, PubMed]; LECT2 modulates dendritic cell function after Helicobacter pylori infection via the CD209a receptor., [RefSeq, PubMed]; Marginal zone SIGN-R1(+) macrophages are essential for the maturation of germinal center B cells in the spleen., [RefSeq, PubMed]; On dendritic cells (DCs) it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Forms a first contact between DC and resting T cell, througth ICAM3 binding, facilitating the downstream DC-T cell clustering process and DC-induced proliferation of resting T Cells., [UniProtKB, UniProtKB]; Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens., [UniProtKB, UniProtKB]; Sepsis-induced DC-SIGN expression in IECs plays a significant role in regulating acute intestinal injury and systemic inflammatory response. The inhibition of DC-SIGN exhibited protective effects on sepsis-associated organ injury and systemic inflammation., [RefSeq, PubMed]; Study showed that SIGN-R1 participates in the recognition of influenza virus by interacting with N-linked glycans present in glycoproteins of the virion envelope., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAT9;Q91ZW5", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0001618 virus receptor activity;GO:0005537 D-mannose binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0006955 immune response;GO:0007159 leukocyte cell-cell adhesion;GO:0046718 symbiont entry into host cell;GO:0042102 positive regulation of T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91ZX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35648-1", "uniprot_id": "CETN3_MOUSE", "mass": 19519.0, "length": 167, "protein_name": "Centrin-3", "gene_name": "Cetn3", "organism": "Mouse", "refseq_name": "centrin-3", "refseq_ac": "NP_031710", "gene_names_uniprotkb": "Cetn3; Cen3", "gene_names_refseq": "Cetn3; MmCEN3", "protein_names_uniprotkb": "Centrin-3", "protein_names_refseq": "centrin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:12626)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25428506;30647131;34428180;9256449", "class_list": "", "function": "As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores., [UniProtKB, UniProtKB]; Plays a fundamental role in microtubule-organizing center structure and function., [UniProtKB]; Removal of CETN2 and CETN3 activity from the lumen of the connecting cilium (CC) destabilized the photoreceptor axoneme and reduced the CC length as early as postnatal day 22 (P22)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0031683 G-protein beta/gamma-subunit complex binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0005815 microtubule organizing center;GO:0005814 centriole", "go_biological_process": "GO:0015031 protein transport;GO:0051301 cell division;GO:0000226 microtubule cytoskeleton organization;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35648-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TJ91-1", "uniprot_id": "L2GL2_MOUSE", "mass": 114323.0, "length": 1027, "protein_name": "LLGL scribble cell polarity complex component 2", "gene_name": "Llgl2", "organism": "Mouse", "refseq_name": "LLGL scribble cell polarity complex component 2 isoform 2", "refseq_ac": "NP_001239461", "gene_names_uniprotkb": "Llgl2; Llglh2", "gene_names_refseq": "9130006H11Rik; Llgl2; Llglh2", "protein_names_uniprotkb": "LLGL scribble cell polarity complex component 2; Lethal giant larvae-like protein 2; Lethal(2) giant larvae protein homolog 2", "protein_names_refseq": "LLGL scribble cell polarity complex component 2 isoform 2; LLGL scribble cell polarity complex component 2; lethal giant larvae-like protein 2; lethal(2) giant larvae protein homolog 2", "tax_id": 10090, "disease": "brain cancer (Disease Ontology:DOID:1319); cancer (Disease Ontology:DOID:162); kidney cancer (Disease Ontology:DOID:263); carcinoma (Disease Ontology:DOID:305); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (mmu:217325)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21606200;21750661;25428506;30084848;34428180;35820727", "class_list": "", "function": "Data suggest that mammalian Llgl2 is required for proper polarized invasion of trophoblasts and efficient branching morphogenesis during placental development, but, unlike its Drosophila ortholog, it does not function as a canonical tumor suppressor gene., [RefSeq, PubMed]; Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9507, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B1ATB0;Q6YP20;Q8K1X0", "ec_number_list": "", "go_molecular_function": "GO:0045159 myosin II binding;GO:0005096 GTPase activator activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0051294 establishment of spindle orientation;GO:0016332 establishment or maintenance of polarity of embryonic epithelium;GO:0032878 regulation of establishment or maintenance of cell polarity;GO:0015820 L-leucine transport;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q3TJ91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70167-1", "uniprot_id": "P3C2G_MOUSE", "mass": 171580.0, "length": 1506, "protein_name": "Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma", "gene_name": "Pik3c2g", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pik3c2g", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma; 2.7.1.137; 2.7.1.154; PI3K-C2-gamma; Phosphoinositide 3-kinase-C2-gamma; PtdIns-3-kinase C2 subunit gamma", "protein_names_refseq": "", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:18705); (R-MMU-1660499); (R-MMU-1660514)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "20536348;21750661;31219806;9514948", "class_list": "", "function": "Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers (PubMed:9514948). May play a role in SDF1A-stimulated chemotaxis., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70168", "ec_number_list": "2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.1", "go_molecular_function": "GO:0005524 ATP binding;GO:0035091 phosphatidylinositol binding;GO:0016303 1-phosphatidylinositol-3-kinase activity;GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0006935 chemotaxis;GO:0016477 cell migration;GO:0048015 phosphatidylinositol-mediated signaling;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O70167-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CCT7-1", "uniprot_id": "NSUN3_MOUSE", "mass": 39182.0, "length": 348, "protein_name": "tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial", "gene_name": "Nsun3", "organism": "Mouse", "refseq_name": "tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial isoform 1", "refseq_ac": "NP_849256", "gene_names_uniprotkb": "Nsun3", "gene_names_refseq": "6720484A09Rik; Nsun3", "protein_names_uniprotkb": "tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial; 2.1.1.-; NOL1/NOP2/Sun domain family member 3", "protein_names_refseq": "NOL1/NOP2/Sun domain family 3; putative methyltransferase NSUN3; tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial isoform 1; tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 48 (Disease Ontology:DOID:0112112)", "pathway": " (mmu:106338)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;29103146;36949224", "class_list": "", "function": "Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met). mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position. mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation., [UniProtKB, UniProtKB]; NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Nsun3 regulates embryonic stem cell differentiation by promoting mitochondrial activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TE43", "ec_number_list": "2.1.1.-", "go_molecular_function": "GO:0016428 tRNA (cytidine-5-)-methyltransferase activity;GO:0000049 tRNA binding;GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0031167 rRNA methylation;GO:0070129 regulation of mitochondrial translation;GO:0002127 tRNA wobble base cytosine methylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CCT7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6GQW0-1", "uniprot_id": "ABTB3_MOUSE", "mass": 121561.0, "length": 1109, "protein_name": "Ankyrin repeat- and BTB/POZ domain-containing protein 3", "gene_name": "Abtb3", "organism": "Mouse", "refseq_name": "ankyrin repeat- and BTB/POZ domain-containing protein 3 isoform 2", "refseq_ac": "NP_001017525", "gene_names_uniprotkb": "Abtb3; Btbd11", "gene_names_refseq": "6330404E16Rik; Abtb3; Btbd11", "protein_names_uniprotkb": "Ankyrin repeat- and BTB/POZ domain-containing protein 3; BTB/POZ domain-containing protein 11", "protein_names_refseq": "BTB (POZ) domain containing 11; BTB/POZ domain-containing protein 11; ankyrin repeat and BTB/POZ domain-containing protein 3; ankyrin repeat and BTB/POZ domain-containing protein BTBD11; ankyrin repeat- and BTB/POZ domain-containing protein 3 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74007)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;37261953", "class_list": "", "function": "Btbd11 supports cell-type-specific synaptic function., [RefSeq, PubMed]; Cortical and hippocampal inhibitory interneuron-specific protein localized at glutamatergic (excitatory) synapses, where it supports cell type-specific synaptic function., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9481, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PCZ7;Q8CAD2;Q8CDA2;Q9D3B9", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0016020 membrane", "go_biological_process": "GO:0035249 synaptic transmission, glutamatergic;GO:0035640 exploration behavior;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6GQW0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZQ0-1", "uniprot_id": "NPAS3_MOUSE", "mass": 100458.0, "length": 925, "protein_name": "Neuronal PAS domain-containing protein 3", "gene_name": "Npas3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Npas3; Mop6", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuronal PAS domain-containing protein 3; Basic-helix-loop-helix-PAS protein MOP6; Member of PAS protein 6; Neuronal PAS3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:27386)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10534623;15347806;21750661;22645316;25428506;32848054;35822049;40885482", "class_list": "", "function": "May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQP4", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0001964 startle response;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007626 locomotory behavior;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9QZQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99M04-1", "uniprot_id": "LIAS_MOUSE", "mass": 41879.0, "length": 373, "protein_name": "Lipoyl synthase, mitochondrial", "gene_name": "Lias", "organism": "Mouse", "refseq_name": "lipoyl synthase, mitochondrial isoform 2", "refseq_ac": "NP_001297541", "gene_names_uniprotkb": "Lias; LIAS; Lip1", "gene_names_refseq": "2900022L22Rik; 4933425M12Rik; 7a5ex; LS; Lias; lip-syn", "protein_names_uniprotkb": "Lipoyl synthase, mitochondrial; 2.8.1.8; LS; Lip-syn; Lipoate synthase; Lipoic acid synthase; mLIP1", "protein_names_refseq": "lipoate synthase; lipoic acid synthase; lipoyl synthase, mitochondrial isoform 2; lipoyl synthase, mitochondrial", "tax_id": 10090, "disease": "pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649)", "pathway": " (mmu:79464); (R-MMU-9857492)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11389890;16135825;18845616;21750661;25605945;31219806;33263565;34428180;36210013;37341891", "class_list": "", "function": "Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives., [UniProtKB, HAMAP, UniProtKB]; Development of homozygous embryos lacking Lias is retarded., [RefSeq, PubMed]; Enhanced neutrophil sequestration in the livers of Lias+/- mice was associated with increased hepatocyte injury and increased gene expression of growth-related oncogene, E-selectin, and VCAM-1 in the liver and/or lung., [RefSeq, PubMed]; Lias overexpression alleviates pulmonary injury induced by fine particulate matter in mice., [RefSeq, PubMed]; Overexpression of the Lias gene attenuates hepatic steatosis in Leprdb/db mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543M1", "ec_number_list": "2.8.1.8", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016992 lipoate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006954 inflammatory response;GO:0006979 response to oxidative stress;GO:0032496 response to lipopolysaccharide;GO:0001843 neural tube closure;GO:0009249 protein lipoylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99M04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSY6-1", "uniprot_id": "CELF4_MOUSE", "mass": 51932.0, "length": 486, "protein_name": "CUGBP Elav-like family member 4", "gene_name": "Celf4", "organism": "Mouse", "refseq_name": "CUGBP Elav-like family member 4 isoform 22", "refseq_ac": "NP_001139764", "gene_names_uniprotkb": "Celf4; Brul4; Brunol4", "gene_names_refseq": "A230070D14Rik; BRUNOL-4; Brul4; Brunol4; C130060B05Rik; Celf4", "protein_names_uniprotkb": "CUGBP Elav-like family member 4; Bruno-like protein 4; CELF-4; CUG-BP- and ETR-3-like factor 4; RNA-binding protein BRUNOL-4", "protein_names_refseq": "CUG-BP- and ETR-3-like factor 4; CUGBP Elav-like family member 4 isoform 22; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding protein; bruno-like protein 4", "tax_id": 10090, "disease": "myotonic dystrophy type 1 (Disease Ontology:DOID:11722); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:108013)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10893231;11158314;12438720;15988035;21750661;35306363;37758766", "class_list": "", "function": "CELF protein activity is required for normal alternative splicing in the heart in vivo and normal CELF-mediated alternative splicing regulation is in turn required for normal cardiac function., [RefSeq, PubMed]; CELF4 regulates spine formation and depression-like behaviors of mice., [RefSeq, PubMed]; Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex. Publication Status: Online-Only, [RefSeq, PubMed]; Cloning and characterization, [RefSeq, PubMed]; RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80Y76;Q811Z7;Q8BKM2;Q8BLM9;Q8BXA2;Q99PE0", "ec_number_list": "", "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0042835 BRE binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:1902866 regulation of retina development in camera-type eye;GO:0001701 in utero embryonic development;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0006376 mRNA splice site recognition", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7TSY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCC6-1", "uniprot_id": "CCM2L_MOUSE", "mass": 52174.0, "length": 481, "protein_name": "Cerebral cavernous malformations 2 protein-like", "gene_name": "Ccm2l", "organism": "Mouse", "refseq_name": "cerebral cavernous malformations 2 protein-like isoform 2", "refseq_ac": "NP_663511", "gene_names_uniprotkb": "Ccm2l; BC020535", "gene_names_refseq": "Ccm2l", "protein_names_uniprotkb": "Cerebral cavernous malformations 2 protein-like; CCM2-like", "protein_names_refseq": "CCM2-like; cerebral cavernous malformations 2 protein-like isoform 2; cerebral cavernous malformations 2 protein-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:228788)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;22898778;23328253;33657857", "class_list": "", "function": "CCM2L (Cerebral Cavernous Malformation 2 Like) Deletion Aggravates Cerebral Cavernous Malformation Through Map3k3-KLF Signaling Pathway., [RefSeq, PubMed]; Ccm2-like is required for cardiovascular development as a novel component of the Heg-CCM pathway., [RefSeq, PubMed]; Loss of CCM2L reduces endocardial growth factor expression and impairs tumor growth and wound healing, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0003007 heart morphogenesis;GO:0042060 wound healing;GO:0003222 ventricular trabecula myocardium morphogenesis;GO:0003209 cardiac atrium morphogenesis;GO:0034111 negative regulation of homotypic cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VCC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIS7-1", "uniprot_id": "CAC1F_MOUSE", "mass": 221926.0, "length": 1985, "protein_name": "Voltage-dependent L-type calcium channel subunit alpha-1F", "gene_name": "Cacna1f", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cacna1f", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit alpha-1F; Voltage-gated calcium channel subunit alpha Cav1.4", "protein_names_refseq": "", "tax_id": 10090, "disease": "congenital stationary night blindness (Disease Ontology:DOID:0050534); Aland Island eye disease (Disease Ontology:DOID:0050630); Timothy syndrome (Disease Ontology:DOID:0060173); congenital stationary night blindness 2A (Disease Ontology:DOID:0110871); X-linked cone-rod dystrophy 3 (Disease Ontology:DOID:0111007); Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "10873387;15452577;21750661;31599954;34418053", "class_list": "", "function": "Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005245 voltage-gated calcium channel activity;GO:0008331 high voltage-gated calcium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0007409 axonogenesis;GO:0006874 intracellular calcium ion homeostasis;GO:0007601 visual perception;GO:0060041 retina development in camera-type eye;GO:0048813 dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JIS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ES70-1", "uniprot_id": "NEK6_MOUSE", "mass": 35742.0, "length": 313, "protein_name": "Serine/threonine-protein kinase Nek6", "gene_name": "Nek6", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase Nek6", "refseq_ac": "NP_001153103", "gene_names_uniprotkb": "Nek6", "gene_names_refseq": "1300007C09Rik; Nek6", "protein_names_uniprotkb": "Serine/threonine-protein kinase Nek6; 2.7.11.34; Never in mitosis A-related kinase 6; NimA-related protein kinase 6", "protein_names_refseq": "NIMA-related expressed kinase 6; never in mitosis A-related kinase 6; nimA-related protein kinase 6; serine/threonine-protein kinase Nek6", "tax_id": 10090, "disease": "", "pathway": " (mmu:59126)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10964517;11516946;11744387;20595392;21750661;32487755;35354613", "class_list": "", "function": "A Single Amino Acid Residue Defines the Difference in NLRP3 Inflammasome Activation between NEK7 and NEK6., [RefSeq, PubMed]; During early embryogenesis nek6 is highly expressed in primary giant trophoblast cells. Later in embryogenesis, nek6 is found in ventricular and sub-ventricular regions., [RefSeq, PubMed]; MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium tuberculosis through Targeting LNX1 via NEK6 Accumulation to Promote Anti-Apoptotic STAT3 Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIRSR, PTN, RAD26L, RBBP6, RPS7, TRIP4, RPS6KB1 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (By similarity). Phosphorylates STAT3 (PubMed:20595392). Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCE9;Q8C6E6;Q9D0E2;Q9DBI8", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007059 chromosome segregation;GO:0007165 signal transduction;GO:0051301 cell division;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ES70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35599-1", "uniprot_id": "OPSG_MOUSE", "mass": 40218.0, "length": 359, "protein_name": "Medium-wave-sensitive opsin 1", "gene_name": "Opn1mw", "organism": "Mouse", "refseq_name": "medium-wave-sensitive opsin 1", "refseq_ac": "NP_032132", "gene_names_uniprotkb": "Opn1mw; Gcp", "gene_names_refseq": "Gcp; ML-opsin; Opn1lw; Opn1mw; Rsvp", "protein_names_uniprotkb": "Medium-wave-sensitive opsin 1; Green cone photoreceptor pigment; Green-sensitive opsin; M opsin; Medium wavelength-sensitive cone opsin", "protein_names_refseq": "G/R opsin; MWS opsin; R/G opsin; green LWS photopigment; green cone photoreceptor pigment; green long wavelength sensitive cone opsin; green-sensitive opsin; medium wavelength-sensitive cone opsin; medium-wave-sensitive opsin 1; midwavelength sensitive opsin; opsin 1 (cone pigments), long-wave-sensitive; red sensitive visual pigment", "tax_id": 10090, "disease": "blue cone monochromacy (Disease Ontology:DOID:0050679); red-green color blindness (Disease Ontology:DOID:13909); red color blindness (Disease Ontology:DOID:13910)", "pathway": " (mmu:14539); (R-MMU-2187335); (R-MMU-418594); (R-MMU-419771)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11055434;21750661;23001562;30948514;9238068", "class_list": "", "function": "G protein-coupled photoreceptor that selectively activates G(i) proteins in response to medium-wavelength (green) light, thereby decreasing intracellular cAMP levels (By similarity). Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade (By similarity). Mediates visual perception of green light in cone photoreceptor cells (By similarity). May contribute to increased spectral sensitivity under dim light conditions (PubMed:11055434)., [UniProtKB, UniProtKB, PubMed]; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q548Z4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0008020 G protein-coupled photoreceptor activity;GO:0009881 photoreceptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment;GO:0120201 cone photoreceptor disc membrane;GO:0016020 membrane", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35599-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BW93-1", "uniprot_id": "C5AR2_MOUSE", "mass": 38199.0, "length": 344, "protein_name": "C5a anaphylatoxin chemotactic receptor 2", "gene_name": "C5ar2", "organism": "Mouse", "refseq_name": "C5a anaphylatoxin chemotactic receptor 2", "refseq_ac": "NP_001139477", "gene_names_uniprotkb": "C5ar2; C5l2; Gpr77", "gene_names_refseq": "C5L2; C5ar2; E030029A11Rik; Gpr77", "protein_names_uniprotkb": "C5a anaphylatoxin chemotactic receptor 2; Complement component 5a receptor 2; G protein-coupled receptor 77", "protein_names_refseq": "C5a anaphylatoxin chemotactic receptor 2; C5a anaphylatoxin chemotactic receptor C5L2; G protein-coupled receptor 77", "tax_id": 10090, "disease": "", "pathway": " (mmu:319430); (R-MMU-375276); (R-MMU-977606)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "15784721;15833747;16204243;17158873;17242355;21750661;37275893;39021433", "class_list": "", "function": "C5L2 appears to bind complement factor C5a and C5a des Arg by different mechanisms, and, unlike C5a receptor (C5aR), C5L2 uses critical residues in its N-terminal domain for binding only to C5a des Arg., [RefSeq, PubMed]; C5aR2 Deficiency Lessens C5aR1 Distribution and Expression in Neutrophils and Macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; Data provide the first evidence for a role for C5a receptor C5L2 in balancing the biological responses to Complement 5a, [RefSeq, PubMed]; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. Also acts as a receptor for dearginated forms of C3a, C4a and C5a anaphylatoxin peptides (ASP/C3adesArg, C4adesArg and C5adesArg, respectively). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The complement anaphylatoxin C5a-binding protein, C5L2 (GPR77) has an anti-inflammatory role, [RefSeq, PubMed]; The complement receptor C5aR2 regulates neutrophil activation and function contributing to neutrophil-driven epidermolysis bullosa acquisita. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RQI1;Q3TVM8", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004878 complement component C5a receptor activity;GO:0004875 complement receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0045177 apical part of cell;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0032715 negative regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BW93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35377-1", "uniprot_id": "OPRX_MOUSE", "mass": 40491.0, "length": 367, "protein_name": "Nociceptin receptor", "gene_name": "Oprl1", "organism": "Mouse", "refseq_name": "nociceptin receptor isoform 1", "refseq_ac": "NP_001239494", "gene_names_uniprotkb": "Oprl1; Oor; Oprl", "gene_names_refseq": "KOR-3; KOR3; LC132; MOR-C; NOP; ORGC; ORL1; Oprl1; Oprl; XOR1; morc", "protein_names_uniprotkb": "Nociceptin receptor; K3 opiate receptor; KOR-3; Kappa-type 3 opioid receptor; ORGC; Orphanin FQ receptor", "protein_names_refseq": "K3 opiate receptor; N/OFQ receptor; kappa-type 3 opioid receptor; nociceptin receptor isoform 1; nociceptin receptor; nociceptin/ orphaninFQ receptor", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041); sciatic neuropathy (Disease Ontology:DOID:11446); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); cocaine abuse (Disease Ontology:DOID:809); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:18389); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "12217419;12814369;21750661;23652222;36326637;7603458;7797625;7802669;8794880;9155012;9755860", "class_list": "", "function": "Behavioral and neurochemical effects of nociceptin/orphanin FQ receptor activation in the social defeat protocol., [RefSeq, PubMed]; G protein-coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q60645;Q8VI74;Q9QUT5;Q9Z2M8;Q9Z2M9;Q9Z2N0", "ec_number_list": "", "go_molecular_function": "GO:0001626 nociceptin receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0043005 neuron projection;GO:0097060 synaptic membrane;GO:0016020 membrane", "go_biological_process": "GO:1904059 regulation of locomotor rhythm;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0019722 calcium-mediated signaling;GO:0035095 behavioral response to nicotine", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P35377-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01139-1", "uniprot_id": "NGF_MOUSE", "mass": 27077.0, "length": 241, "protein_name": "Beta-nerve growth factor", "gene_name": "Ngf", "organism": "Mouse", "refseq_name": "beta-nerve growth factor isoform B precursor", "refseq_ac": "NP_001106168", "gene_names_uniprotkb": "Ngf; Ngfb", "gene_names_refseq": "Ngfb; Ngf; beta-NGF", "protein_names_uniprotkb": "Beta-nerve growth factor; Beta-NGF", "protein_names_refseq": "beta-nerve growth factor isoform B precursor; beta-nerve growth factor; nerve growth factor, beta", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); obstructive sleep apnea (Disease Ontology:DOID:0050848); stroke (Disease Ontology:DOID:0051061); chronic pancreatitis (Disease Ontology:DOID:0051065); withdrawal disorder (Disease Ontology:DOID:0060001); hereditary sensory and autonomic neuropathy type 5 (Disease Ontology:DOID:0070145); overactive bladder syndrome (Disease Ontology:DOID:0070355); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); chronic asthma (Disease Ontology:DOID:0080809); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); sensorineural hearing loss (Disease Ontology:DOID:10003); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); separation anxiety disorder (Disease Ontology:DOID:10685); hypertension (Disease Ontology:DOID:10763); cryptorchidism (Disease Ontology:DOID:11383); neurogenic bladder (Disease Ontology:DOID:12143); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); pulmonary sarcoidosis (Disease Ontology:DOID:13406); bladder neck obstruction (Disease Ontology:DOID:13948); interstitial cystitis (Disease Ontology:DOID:13949); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); cystitis (Disease Ontology:DOID:1679); glaucoma (Disease Ontology:DOID:1686); atherosclerosis (Disease Ontology:DOID:1936); opiate dependence (Disease Ontology:DOID:2559); morphine dependence (Disease Ontology:DOID:2560); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); interstitial lung disease (Disease Ontology:DOID:3082); atopic dermatitis (Disease Ontology:DOID:3310); bipolar disorder (Disease Ontology:DOID:3312); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); myofascial pain syndrome (Disease Ontology:DOID:431); rhinitis (Disease Ontology:DOID:4483); borna disease (Disease Ontology:DOID:5154); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); diabetic retinopathy (Disease Ontology:DOID:8947); degenerative disc disease (Disease Ontology:DOID:90); hyperhomocysteinemia (Disease Ontology:DOID:9279); bacterial meningitis (Disease Ontology:DOID:9470); cannabis abuse (Disease Ontology:DOID:9505); diabetic neuropathy (Disease Ontology:DOID:9743); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:18049); (R-MMU-1257604); (R-MMU-167060); (R-MMU-170968); (R-MMU-170984); (R-MMU-177504); (R-MMU-187042); (R-MMU-198203); (R-MMU-205017); (R-MMU-205025); (R-MMU-205043); (R-MMU-209543); (R-MMU-209560); (R-MMU-209563)", "pathway_count": 14, "publication_count": 18, "publication_id_list": "1284621;1956407;20036257;21750661;22155786;22649032;23785138;24908487;26144237;30061605;3670305;38646645;4566923;6327169;6336309;6688123;8201620;9351801", "class_list": "", "function": "HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy. Publication Status: Online-Only, [RefSeq, PubMed]; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:20036257). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:22649032). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse (PubMed:22155786). In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (PubMed:20036257). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer (PubMed:22649032, PubMed:26144237). The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (PubMed:22649032)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 55, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q63864;Q6LDB7", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding;GO:0008083 growth factor activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity;GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0005163 nerve growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0031904 endosome lumen;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:2000648 positive regulation of stem cell proliferation;GO:0001934 positive regulation of protein phosphorylation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P01139-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NXZ1-1", "uniprot_id": "KRBD3_MOUSE", "mass": 111257.0, "length": 1043, "protein_name": "KRAB domain-containing protein 3", "gene_name": "Krabd3; Krba1", "organism": "Mouse", "refseq_name": "KRAB domain-containing protein 3 isoform 2", "refseq_ac": "NP_598683", "gene_names_uniprotkb": "Krabd3; Krba1; Kiaa1862; Krba1; MNCb-1826", "gene_names_refseq": "A930040G15Rik; Krabd3; Krba1", "protein_names_uniprotkb": "KRAB domain-containing protein 3; KRABD3", "protein_names_refseq": "KRAB domain-containing protein 3 isoform 2; KRAB domain-containing protein 3; KRAB-A domain containing 1; protein KRBA1", "tax_id": 10090, "disease": "", "pathway": " (mmu:77827); (R-MMU-212436)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;25428506;31219806;36852467", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QNG7;Q69Z85;Q9JJG3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6NXZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97930-1", "uniprot_id": "KTHY_MOUSE", "mass": 23915.0, "length": 212, "protein_name": "Thymidylate kinase", "gene_name": "Dtymk", "organism": "Mouse", "refseq_name": "thymidylate kinase isoform 1", "refseq_ac": "NP_001099137", "gene_names_uniprotkb": "Dtymk; Tmk", "gene_names_refseq": "CDC8; D10Ertd203e; Dtymk; TMPK; TYPK; Tmk; mtmk", "protein_names_uniprotkb": "Thymidylate kinase; 2.7.4.9; dTMP kinase", "protein_names_refseq": "dTMP kinase; thymidylate kinase isoform 1; thymidylate kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:21915); (R-MMU-499943)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;31219806;34428180;36210013;8845311", "class_list": "", "function": "Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP, with ATP as the preferred phosphoryl donor in the presence of Mg(2+)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2L0;Q8K2S2", "ec_number_list": "2.7.4.9", "go_molecular_function": "GO:0005524 ATP binding;GO:0004798 dTMP kinase activity;GO:0004550 nucleoside diphosphate kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0046105 thymidine biosynthetic process;GO:0071363 cellular response to growth factor stimulus;GO:0006233 dTDP biosynthetic process;GO:0009165 nucleotide biosynthetic process;GO:0006227 dUDP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P97930-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91YX5-1", "uniprot_id": "LGAT1_MOUSE", "mass": 43088.0, "length": 370, "protein_name": "Acyl-CoA:lysophosphatidylglycerol acyltransferase 1", "gene_name": "Lpgat1", "organism": "Mouse", "refseq_name": "acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2", "refseq_ac": "NP_758470", "gene_names_uniprotkb": "Lpgat1; Fam34a", "gene_names_refseq": "LPLAT7; Lpgat1", "protein_names_uniprotkb": "Acyl-CoA:lysophosphatidylglycerol acyltransferase 1; 2-acylglycerophosphocholine O-acyltransferase; 2.3.1.-; 2.3.1.22; 2.3.1.62; Acyl-CoA:monoacylglycerol acyltransferase LPGAT1; LPLAT7; Lysophospholipid acyltransferase 7; Stearoyl-CoA:1-lyso-2-acyl-PE acyltransferase", "protein_names_refseq": "2-acylglycerophosphocholine O-acyltransferase; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2; acyl-CoA:lysophosphatidylglycerol acyltransferase 1; acyl-CoA:monoacylglycerol acyltransferase LPGAT1; lysophospholipid acyltransferase 7; stearoyl-CoA:1-lyso-2-acyl-PE acyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:226856); (R-MMU-1482925)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;20018982;21750661;31219806;34890643;35131264;36049524;37217003;37917582", "class_list": "", "function": "Identification and characterization of LPLAT7 as an sn-1-specific lysophospholipid acyltransferase., [RefSeq, PubMed]; LPGAT1 controls MEGDEL syndrome by coupling phosphatidylglycerol remodeling with mitochondrial transport., [RefSeq, PubMed]; LPGAT1 controls the stearate/palmitate ratio of phosphatidylethanolamine and phosphatidylcholine in sn-1 specific remodeling., [RefSeq, PubMed]; LPGAT1, a newly identified MGAT enzyme, plays a significant role in hepatic triacylglycerol synthesis and secretion in db/db mice., [RefSeq, PubMed]; LPGAT1/LPLAT7 regulates acyl chain profiles at the sn-1 position of phospholipids in murine skeletal muscles., [RefSeq, PubMed]; Lysophospholipid acyltransferase involved in fatty acyl chain remodeling of glycerophospholipids in the endoplasmic reticulum membrane (PubMed:35131264). Selectively catalyzes the transfer and esterification of saturated long-chain fatty acids from acyl-CoA to the sn-1 position of 1-lyso-2-acyl phosphatidylethanolamines (1-lyso-PE, LPE), with a preference for stearoyl CoA over palmitoyl CoA as acyl donor (PubMed:36049524). Acts in concert with an unknown phospholipase A1 to convert palmitate PE species into stearate ones. Provides substrates to the PE methylation pathway, controlling stearate/palmitate composition of PE and phosphatidylcholine (PC) species with an overall impact on de novo hepatic lipid synthesis, body fat content and life span (PubMed:35131264). Can acylate lysophosphatidylglycerols (LPG) using various saturated fatty acyl-CoAs as acyl donors (By similarity). Can also acylate monoacylglycerols with a preference for 2-monoacylglycerols over 1-monoacylglycerols (PubMed:20018982, PubMed:35131264). Has no activity toward lysophosphatidic acids (LPA) and lysophosphatidylcholines (LPC) (PubMed:35131264)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.51;2.3.1.23;2.3.1.67;2.3.1.25;2.3.1.-;2.3.1.121;2.3.1.n6;2.3.1.n7;2.3.1.20;2.3.1.22;2.3.1.62", "go_molecular_function": "GO:0071617 lysophospholipid acyltransferase activity;GO:0016746 acyltransferase activity;GO:0003846 2-acylglycerol O-acyltransferase activity;GO:0071618 lysophosphatidylethanolamine acyltransferase activity;GO:0047190 2-acylglycerophosphocholine O-acyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0036152 phosphatidylethanolamine acyl-chain remodeling;GO:0045723 positive regulation of fatty acid biosynthetic process;GO:0019432 triglyceride biosynthetic process;GO:0008654 phospholipid biosynthetic process;GO:0036149 phosphatidylinositol acyl-chain remodeling", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91YX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C3R1-1", "uniprot_id": "BRAT1_MOUSE", "mass": 89086.0, "length": 822, "protein_name": "Integrator complex assembly factor BRAT1", "gene_name": "Brat1", "organism": "Mouse", "refseq_name": "integrator complex assembly factor BRAT1 isoform 3", "refseq_ac": "NP_001263216", "gene_names_uniprotkb": "Brat1; Baat1", "gene_names_refseq": "Baat1; Brat1", "protein_names_uniprotkb": "Integrator complex assembly factor BRAT1; BRCA1-associated ATM activator 1; BRCA1-associated protein required for ATM activation protein 1", "protein_names_refseq": "BRCA1-associated protein required for ATM activation protein 1; integrator complex assembly factor BRAT1 isoform 3; integrator complex assembly factor BRAT1", "tax_id": 10090, "disease": "", "pathway": " (mmu:231841)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10693804;21183079;21750661;22977523;25428506;25428507;25605945;25631046;25657994;30084848;30779550;34428180", "class_list": "", "function": "A similar gene in human encodes a Breast Cancer 1 (BRCA1) interacting protein that is involved in cell cycle checkpoint signaling. The similar human protein is localized to DNA double strand breaks caused by ionizing radiation, and regulates cellular DNA damage response through interactions with Ataxia Telangiectasia Mutated (ATM) and DNA-dependent Protein Kinase. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]., [RefSeq]; Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex. Associates with INTS9 and INTS11 in the cytoplasm and blocks the active site of INTS11 to inhibit the endonuclease activity of INTS11 before formation of the full integrator complex. Following dissociation of WDR73 of the complex, BRAT1 facilitates the nuclear import of the INTS9-INTS11 heterodimer. In the nucleus, INTS4 is integrated to the INTS9-INTS11 heterodimer and BRAT1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6). BRAT1 is also involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Plays a role in regulating mitochondrial function and cell proliferation. Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; Ndfip1 is required during stress for ubiquitinating and trafficking BRAT1 into the nucleus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDC8;Q3U442;Q6NV65;Q8C3T3;Q9JKU7", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008428 ribonuclease inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0008283 cell population proliferation;GO:0016477 cell migration;GO:0030307 positive regulation of cell growth;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8C3R1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922K7-1", "uniprot_id": "NOP2_MOUSE", "mass": 86752.0, "length": 793, "protein_name": "28S rRNA (cytosine-C(5))-methyltransferase", "gene_name": "Nop2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nop2; Nol1", "gene_names_refseq": "", "protein_names_uniprotkb": "28S rRNA (cytosine-C(5))-methyltransferase; 2.1.1.-; Nucleolar protein 1; Nucleolar protein 2 homolog; Proliferating-cell nucleolar antigen p120; Proliferation-associated nucleolar protein p120", "protein_names_refseq": "", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (mmu:110109)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "1394192;21183079;21750661;24463520;31219806;34428180;34887587;39627609", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA. Required for efficient rRNA processing and 60S ribosomal subunit biogenesis. Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes. May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4W9", "ec_number_list": "2.1.1.-", "go_molecular_function": "GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:1901796 regulation of signal transduction by p53 class mediator;GO:0006364 rRNA processing;GO:0000027 ribosomal large subunit assembly;GO:0001825 blastocyst formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q922K7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CY21-1", "uniprot_id": "BUD23_MOUSE", "mass": 31587.0, "length": 281, "protein_name": "18S rRNA (guanine-N(7))-methyltransferase", "gene_name": "Bud23", "organism": "Mouse", "refseq_name": "18S rRNA (guanine-N(7))-methyltransferase isoform 1", "refseq_ac": "NP_079651", "gene_names_uniprotkb": "Bud23; Wbscr22", "gene_names_refseq": "1110003N24Rik; Bud23; Wbscr22", "protein_names_uniprotkb": "18S rRNA (guanine-N(7))-methyltransferase; 2.1.1.-; Bud site selection protein 23 homolog; Williams-Beuren syndrome chromosomal region 22 protein homolog; rRNA methyltransferase and ribosome maturation factor", "protein_names_refseq": "18S rRNA (guanine-N(7))-methyltransferase isoform 1; Williams Beuren syndrome chromosome region 22; Williams-Beuren syndrome chromosomal region 22 protein homolog; bud site selection protein 23 homolog; probable 18S rRNA (guanine-N(7))-methyltransferase; rRNA methyltransferase and ribosome maturation factor; ribosome biogenesis methyltransferase WBSCR22", "tax_id": 10090, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (mmu:66138); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12073013;21750661;25605945;31219806", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U915", "ec_number_list": "4.2.99.18;3.1.-.-;3.6.1.-;2.7.11.1;2.1.1.-;2.7.11.26", "go_molecular_function": "GO:0016435 rRNA (guanine) methyltransferase activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0048471 perinuclear region of cytoplasm;GO:0043527 tRNA methyltransferase complex", "go_biological_process": "GO:0070476 rRNA (guanine-N7)-methylation;GO:2000234 positive regulation of rRNA processing;GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CY21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4G1-1", "uniprot_id": "LTBP4_MOUSE", "mass": 178642.0, "length": 1666, "protein_name": "Latent-transforming growth factor beta-binding protein 4", "gene_name": "Ltbp4", "organism": "Mouse", "refseq_name": "latent-transforming growth factor beta-binding protein 4 isoform b precursor", "refseq_ac": "NP_001107021", "gene_names_uniprotkb": "Ltbp4", "gene_names_refseq": "2310046A13Rik; Ltbp4", "protein_names_uniprotkb": "Latent-transforming growth factor beta-binding protein 4; LTBP-4", "protein_names_refseq": "LTBP-4; latent-transforming growth factor beta-binding protein 4 isoform b precursor", "tax_id": 10090, "disease": "autosomal recessive cutis laxa type IC (Disease Ontology:DOID:0070139); cutis laxa (Disease Ontology:DOID:3144)", "pathway": " (mmu:108075); (R-MMU-2129379); (R-MMU-2173789)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;12208849;15466481;19836010;21183079;21750661;25713297;31219806;34428180", "class_list": "", "function": "Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta., [UniProtKB, UniProtKB]; LTBP-4 has a role in targeting and activation of TGF-beta1 which regulates BMP-4 signaling in mouse lung, [RefSeq, PubMed]; Mice homozygous for the disrupted allele develop severe pulmonary emphysema, cardiomyopathy, and colorectal cancer., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "E9QPD9;Q8K4G0", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050431 transforming growth factor beta binding;GO:0019838 growth factor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0001527 microfibril;GO:0099126 transforming growth factor beta complex", "go_biological_process": "GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0046879 hormone secretion;GO:0048251 elastic fiber assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8K4G1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0N7-1", "uniprot_id": "CAF1B_MOUSE", "mass": 63132.0, "length": 572, "protein_name": "Chromatin assembly factor 1 subunit B", "gene_name": "Chaf1b", "organism": "Mouse", "refseq_name": "chromatin assembly factor 1 subunit B isoform 1", "refseq_ac": "NP_082359", "gene_names_uniprotkb": "Chaf1b", "gene_names_refseq": "2600017H24Rik; CAF-I p60; CAF-Ip60; CAF1A; CAF1P60; CAF1; Chaf1b; MPHOSPH7", "protein_names_uniprotkb": "Chromatin assembly factor 1 subunit B; CAF-1 subunit B; CAF-I 60 kDa subunit; CAF-I p60; Chromatin assembly factor I p60 subunit", "protein_names_refseq": "CAF-1 subunit B; CAF-I 60 kDa subunit; chromatin assembly factor 1 subunit B isoform 1; chromatin assembly factor 1, subunit B (p60); chromatin assembly factor I p60 subunit", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); prostate cancer (Disease Ontology:DOID:10283); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (mmu:110749)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;21952136;25428506;25605945;30084848;31219806;33949677;34428180;34906611;37205848", "class_list": "", "function": "Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; CHAF1b, chromatin assembly factor-1 subunit b, is essential for mouse preimplantation embryos., [RefSeq, PubMed]; Chromatin assembly factor 1B critically controls the early development but not function acquisition of invariant natural killer T cells in mice., [RefSeq, PubMed]; Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0006334 nucleosome assembly;GO:0006335 DNA replication-dependent chromatin assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9D0N7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TN73-1", "uniprot_id": "CASD1_MOUSE", "mass": 91603.0, "length": 797, "protein_name": "N-acetylneuraminate (7)9-O-acetyltransferase", "gene_name": "Casd1", "organism": "Mouse", "refseq_name": "N-acetylneuraminate (7)9-O-acetyltransferase isoform 1", "refseq_ac": "NP_663373", "gene_names_uniprotkb": "Casd1; Cas1; Cast1", "gene_names_refseq": "Cas1p; Cas1; Casd1; Cast1; SOAT", "protein_names_uniprotkb": "N-acetylneuraminate (7)9-O-acetyltransferase; 2.3.1.45; CAS1 domain-containing protein 1; CAS1 protein; Cas1p; SOAT; Sialate O-acetyltransferase", "protein_names_refseq": "CAS1 domain-containing protein 1; N-acetylneuraminate (7)9-O-acetyltransferase isoform 1; N-acetylneuraminate (7)9-O-acetyltransferase; N-acetylneuraminate 9-O-acetyltransferase; O-acetyltransferase; sialate O-acetyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:213819)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;12840045;19026546;21750661;34428180", "class_list": "", "function": "Key enzyme in the biosynthesis of O-acetylated (O-Ac) sialoglycans such as gangliosides O-AcGD3 and O-AcGD2, which affect various processes such as cell-cell interactions, host-pathogen recognition. Catalyzes the transfer of an acetyl group from a donor, the acetyl-coenzyme-A molecule (acetyl-CoA), to the C7/8/9 OH-position of a sialic acid residue. The primary site of O-acetyl group transfer on sialic acid seems to depend on cell type and can be C7, from which the O-acetyl group could subsequently migrate to the C8 and then to the C9 position, or at C9 with possibility of migrating to the C8 and then to the C7 position. Together with ST8SIA1 (GD3 synthase) it increases the levels of ganglioside Ac-O-7-GD3. Can transfer the acetyl group from acetyl-CoA to free sialate (N-acetylneuraminate, Neu5Ac) in vitro, but has preferred substrate specificity for CMP-activated sialate (CMP-Neu5Ac), resulting in the formation of 9-O-acetylated CMP-Neu5Ac (CMP-Neu5,9Ac2). CMP-Neu5,9Ac2 may be used by sialyltransferases as a sialate donor for glycoconjugate acceptors such as ganglioside GD3. O-acetylation at position C9 of ganglioside GD3 can counteract the pro-apoptotic effects of the ganglioside GD3 in tumor cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q1RN01;Q6PD39;Q8VEF5", "ec_number_list": "2.3.1.45", "go_molecular_function": "GO:0047186 N-acetylneuraminate 9-O-acetyltransferase activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7TN73-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10923-1", "uniprot_id": "OSTP_MOUSE", "mass": 32459.0, "length": 294, "protein_name": "Osteopontin", "gene_name": "Spp1", "organism": "Mouse", "refseq_name": "osteopontin isoform 4 precursor", "refseq_ac": "NP_001191162", "gene_names_uniprotkb": "Spp1; Eta-1; Op; Spp-1", "gene_names_refseq": "2AR; Apl-1; BNSP; BSPI; Bsp; ETA-1; Eta; OP; Opnl; Opn; Ric; Spp-1; Spp1", "protein_names_uniprotkb": "Osteopontin; 2AR; Bone sialoprotein 1; Calcium oxalate crystal growth inhibitor protein; Early T-lymphocyte activation 1 protein; Minopontin; SPP-1; Secreted phosphoprotein 1", "protein_names_refseq": "44 kDa bone phosphoprotein; bone sialoprotein 1; calcium oxalate crystal growth inhibitor protein; early T-lymphocyte activation 1 protein; minopontin; osteopontin isoform 4 precursor; osteopontin-like protein", "tax_id": 10090, "disease": "glomerulosclerosis (Disease Ontology:DOID:0050851); aortic dissection (Disease Ontology:DOID:0080685); progressive osseous heteroplasia (Disease Ontology:DOID:0111535); prostate carcinoma (Disease Ontology:DOID:10286); kidney failure (Disease Ontology:DOID:1074); urinary bladder cancer (Disease Ontology:DOID:11054); biliary atresia (Disease Ontology:DOID:13608); disease of cellular proliferation (Disease Ontology:DOID:14566); renovascular hypertension (Disease Ontology:DOID:1591); pancreatic cancer (Disease Ontology:DOID:1793); calcinosis (Disease Ontology:DOID:182); melanoma (Disease Ontology:DOID:1909); hepatitis (Disease Ontology:DOID:2237); multiple sclerosis (Disease Ontology:DOID:2377); glomerulonephritis (Disease Ontology:DOID:2921); high grade glioma (Disease Ontology:DOID:3070); coronary artery disease (Disease Ontology:DOID:3393); aortic aneurysm (Disease Ontology:DOID:3627); lung non-small cell carcinoma (Disease Ontology:DOID:3908); tuberculosis (Disease Ontology:DOID:399); coronary restenosis (Disease Ontology:DOID:4247); radiculopathy (Disease Ontology:DOID:4306); myocardial infarction (Disease Ontology:DOID:5844); encephalomyelitis (Disease Ontology:DOID:640); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); myocarditis (Disease Ontology:DOID:820); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:20750); (R-MMU-1474228); (R-MMU-186797); (R-MMU-216083); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10657301;1414495;17242355;19144319;21183079;21750661;22654117;23427088;2351930;2387863;2722855;2726465;2787378;39950214", "class_list": "", "function": "Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity., [UniProtKB, PubMed, PubMed]; Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 36, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 29, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "P19008;Q91VH4", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0005509 calcium ion binding;GO:0005125 cytokine activity;GO:0050840 extracellular matrix binding;GO:0036094 small molecule binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0045177 apical part of cell", "go_biological_process": "GO:0006710 androgen catabolic process;GO:2000866 positive regulation of estradiol secretion;GO:0030644 intracellular chloride ion homeostasis;GO:0007155 cell adhesion;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P10923-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61458-1", "uniprot_id": "CCNH_MOUSE", "mass": 37506.0, "length": 323, "protein_name": "Cyclin-H", "gene_name": "Ccnh", "organism": "Mouse", "refseq_name": "cyclin-H isoform b", "refseq_ac": "NP_001334516", "gene_names_uniprotkb": "Ccnh", "gene_names_refseq": "6330408H09Rik; Ccnh", "protein_names_uniprotkb": "Cyclin-H", "protein_names_refseq": "cyclin-H isoform b", "tax_id": 10090, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:66671); (R-MMU-112382); (R-MMU-113418); (R-MMU-5696395); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-69200); (R-MMU-69202); (R-MMU-69231); (R-MMU-69273); (R-MMU-69656); (R-MMU-72086); (R-MMU-73762); (R-MMU-73772); (R-MMU-73776); (R-MMU-73779); (R-MMU-73863); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-77075); (R-MMU-8939236)", "pathway_count": 25, "publication_count": 9, "publication_id_list": "11319144;11731416;20231280;21750661;25428506;30084848;30779550;31599954;34428180", "class_list": "", "function": "Component of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalyzing the activating threonine phosphorylation of CDKs. Binds and activates cyclin-dependent protein kinase CDK7, the catalytic subunit of CAK (By similarity). CAK activates major mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, and plays a key role in regulating cell cycle progression (By similarity). CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts (By similarity). Involved in cell cycle control and in RNA transcription by RNA polymerase II (By similarity). Its expression and activity are constant throughout the cell cycle., [UniProtKB, UniProtKB]; Inactivation of the retinoblastoma tumor suppressor induces apoptosis protease-activating factor-1 dependent and independent apoptotic pathways during embryogenesis., [RefSeq, PubMed]; Investigated the function of the Cdk7.cyclin H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells, [RefSeq, PubMed]; Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CVJ0;Q9JHV7", "ec_number_list": "", "go_molecular_function": "GO:0016301 kinase activity;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005675 transcription factor TFIIH holo complex;GO:0070985 transcription factor TFIIK complex;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0050821 protein stabilization;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:2000045 regulation of G1/S transition of mitotic cell cycle;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q61458-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XPT3-1", "uniprot_id": "LARG2_MOUSE", "mass": 79514.0, "length": 690, "protein_name": "Xylosyl- and glucuronyltransferase LARGE2", "gene_name": "Large2", "organism": "Mouse", "refseq_name": "xylosyl- and glucuronyltransferase LARGE2 isoform 2", "refseq_ac": "NP_001160105", "gene_names_uniprotkb": "Large2; Gyltl1b", "gene_names_refseq": "5730485C17Rik; Gyltl1b; Large2; Largel; mKIAA4105", "protein_names_uniprotkb": "Xylosyl- and glucuronyltransferase LARGE2; 2.4.-.-; Glycosyltransferase-like 1B; LARGE xylosyl- and glucuronyltransferase 2", "protein_names_refseq": "glycoslytransferase-like 1B; glycosyltransferase-like 1B; glycosyltransferase-like protein LARGE2; xylosyl- and glucuronyltransferase LARGE2 isoform 2; xylosyl- and glucuronyltransferase LARGE2", "tax_id": 10090, "disease": "", "pathway": " (mmu:228366); (R-MMU-9939291)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15958417;21750661;23125099;23135544;25138275;25428506;27496765", "class_list": "glycogene;glycosyltransferase", "function": "Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner (PubMed:15958417, PubMed:23125099, PubMed:23135544, PubMed:25138275). Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:23125099, PubMed:23135544, PubMed:25138275). Supports the maturation of DAG1 more effectively than LARGE1 (By similarity). In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding (PubMed:27496765)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of alpha-dystroglycan in cells and tissues., [RefSeq, PubMed]; The LARGE2 may play a differential role in stabilizing the basement membrane and modifying its functions by augmenting the interactions between laminin globular domain-containing ECM proteins and proteoglycans (PGs)., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 47, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AHG9;Q5XPT2;Q8BJZ8;Q8K253", "ec_number_list": "2.4.2.-;2.4.1.-;2.4.-.-", "go_molecular_function": "GO:0042285 xylosyltransferase activity;GO:0046872 metal ion binding;GO:0002162 dystroglycan binding;GO:0016757 glycosyltransferase activity;GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5XPT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHB0-1", "uniprot_id": "NOD1_MOUSE", "mass": 107740.0, "length": 953, "protein_name": "Nucleotide-binding oligomerization domain-containing protein 1", "gene_name": "Nod1", "organism": "Mouse", "refseq_name": "nucleotide-binding oligomerization domain-containing protein 1", "refseq_ac": "NP_001164478", "gene_names_uniprotkb": "Nod1", "gene_names_refseq": "C230079P11; Card4; F830007N14Rik; Nlrc1; Nod1; mNod1", "protein_names_uniprotkb": "Nucleotide-binding oligomerization domain-containing protein 1; mNod1", "protein_names_refseq": "caspase recruitment domain 4; caspase recruitment domain-containing protein 4; nucleotide-binding oligomerization domain-containing protein 1", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483)", "pathway": " (mmu:107607); (R-MMU-168638); (R-MMU-450302); (R-MMU-450321); (R-MMU-5689896)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "12796777;16211083;19898471;20173027;21715553;21750661;25428506;25428507;27007849;30084848;30779550;31201384;31599954;34428180;37957354;38336763", "class_list": "", "function": "Microbial ligand-independent regulation of lymphopoiesis by NOD1., [RefSeq, PubMed]; NOD1 deficiency ameliorates the progression of diabetic retinopathy by modulating bone marrow-retina crosstalk. Publication Status: Online-Only, [RefSeq, PubMed]; NOD1 mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan., [RefSeq, PubMed]; Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and thus participates in both innate and adaptive immune responses (PubMed:12796777, PubMed:21715553). Specifically recognizes and binds gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP), a dipeptide present in peptidoglycan of Gram-negative bacteria (PubMed:12796777, PubMed:16211083). Preferentially binds iE-DAP in tetrapeptide-containing muropeptides (MurNAc-TetraDAP or TetraDAP) (PubMed:16211083). Ligand binding triggers oligomerization that facilitates the binding and subsequent activation of the proximal adapter receptor-interacting RIPK2 (By similarity). Following recruitment, RIPK2 undergoes 'Met-1'- (linear) and 'Lys-63'-linked polyubiquitination by E3 ubiquitin-protein ligases XIAP, BIRC2, BIRC3 and the LUBAC complex, becoming a scaffolding protein for downstream effectors, triggering activation of the NF-kappa-B and MAP kinases signaling (By similarity). This in turn leads to the transcriptional activation of hundreds of genes involved in immune response (By similarity). Also acts as a regulator of antiviral response elicited by dsRNA and the expression of RLR pathway members by targeting IFIH1 and TRAF3 to modulate the formation of IFIH1-MAVS and TRAF3-MAVS complexes leading to increased transcription of type I IFNs (By similarity). Also acts as a regulator of autophagy via its interaction with ATG16L1, possibly by recruiting ATG16L1 at the site of bacterial entry (PubMed:19898471). Besides recognizing pathogens, also involved in the endoplasmic reticulum stress response: acts by sensing and binding to the cytosolic metabolite sphingosine-1-phosphate generated in response to endoplasmic reticulum stress, initiating an inflammation process that leads to activation of the NF-kappa-B and MAP kinases signaling (PubMed:27007849). In addition, plays a role in insulin trafficking in beta cells in a cell-autonomous manner (PubMed:21715553, PubMed:31201384). Mechanistically, upon recognizing cognate ligands, NOD1 and RIPK2 localize to insulin vesicles where they recruit RAB1A to direct insulin trafficking through the cytoplasm (PubMed:31201384)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUT6", "ec_number_list": "", "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0002221 pattern recognition receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BHB0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15409-1", "uniprot_id": "OPSD_MOUSE", "mass": 39070.0, "length": 348, "protein_name": "Rhodopsin", "gene_name": "Rho", "organism": "Mouse", "refseq_name": "rhodopsin", "refseq_ac": "NP_663358", "gene_names_uniprotkb": "Rho", "gene_names_refseq": "Noerg1; Opn2; Ops; RP4; Rho", "protein_names_uniprotkb": "Rhodopsin", "protein_names_refseq": "L opsin; LWS opsin; long wavelength sensitive opsin; opsin 2; red opsin; rhodopsin; rod opsin", "tax_id": 10090, "disease": "retinitis pigmentosa 4 (Disease Ontology:DOID:0110372); congenital stationary night blindness autosomal dominant 1 (Disease Ontology:DOID:0110862); retinitis pigmentosa (Disease Ontology:DOID:10584); fundus albipunctatus (Disease Ontology:DOID:11105); night blindness (Disease Ontology:DOID:8499)", "pathway": " (mmu:212541); (R-MMU-2453902); (R-MMU-2485179); (R-MMU-2514859); (R-MMU-418594); (R-MMU-419771); (R-MMU-5620916)", "pathway_count": 7, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11910029;12809555;15961391;1978723;19941415;21750661;27353443;27509380;28151698;2844600;7782279;9020854", "class_list": "", "function": "G protein-coupled photoreceptor that activates the G protein transducin (t) signaling pathway in response to light and is essential for image-forming vision under low-light conditions. Required for postnatal photoreceptor cell viability (PubMed:9020854). Activation occurs when the covalently bound 11-cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers G protein-mediated phototransduction. Signal termination occurs via receptor phosphorylation, which promotes binding of arrestin (SAG) and displacement of the G protein alpha subunit (PubMed:27353443)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0D8;Q96DZ2", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030507 spectrin binding;GO:0016918 retinal binding;GO:0005502 11-cis retinal binding;GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0060342 photoreceptor inner segment membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane", "go_biological_process": "GO:0016038 absorption of visible light;GO:0009583 detection of light stimulus;GO:0006468 protein phosphorylation;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P15409-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C186-1", "uniprot_id": "BPIFC_MOUSE", "mass": 56616.0, "length": 509, "protein_name": "BPI fold-containing family C protein", "gene_name": "Bpifc", "organism": "Mouse", "refseq_name": "BPI fold-containing family C protein precursor", "refseq_ac": "NP_808440", "gene_names_uniprotkb": "Bpifc; Bpil2", "gene_names_refseq": "4732454E24; Bpifc; Bpil2", "protein_names_uniprotkb": "BPI fold-containing family C protein; Bactericidal/permeability-increasing protein-like 2", "protein_names_refseq": "BPI fold-containing family C protein precursor; BPI fold-containing family C protein; bactericidal/permeability-increasing protein-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:270757)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope., [UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C186-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CDM4-1", "uniprot_id": "CCD73_MOUSE", "mass": 120389.0, "length": 1066, "protein_name": "Coiled-coil domain-containing protein 73", "gene_name": "Ccdc73", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 73", "refseq_ac": "NP_808268", "gene_names_uniprotkb": "Ccdc73", "gene_names_refseq": "2210415I11Rik; 4931417A20; Ccdc73", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 73", "protein_names_refseq": "coiled-coil domain-containing protein 73", "tax_id": 10090, "disease": "", "pathway": " (mmu:211936)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31599954;34428180;36210013", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A6Z9;Q501M4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CDM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K207-1", "uniprot_id": "CA021_MOUSE", "mass": 13882.0, "length": 121, "protein_name": "Uncharacterized protein C1orf21 homolog", "gene_name": "1700025G04Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C1orf21 homolog", "refseq_ac": "NP_932107", "gene_names_uniprotkb": "1700025G04Rik", "gene_names_refseq": "1700025G04Rik; 2610510E02Rik; 2900042O04Rik", "protein_names_uniprotkb": "Uncharacterized protein C1orf21 homolog", "protein_names_refseq": "uncharacterized protein C1orf21 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69399)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17114649;19144319;21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K207-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DFY8-1", "uniprot_id": "BRNP2_MOUSE", "mass": 89228.0, "length": 783, "protein_name": "BMP/retinoic acid-inducible neural-specific protein 2", "gene_name": "Brinp2", "organism": "Mouse", "refseq_name": "BMP/retinoic acid-inducible neural-specific protein 2 precursor", "refseq_ac": "NP_997466", "gene_names_uniprotkb": "Brinp2; Fam5b; Kiaa1747", "gene_names_refseq": "6430517E21Rik; Brinp2; Fam5b; mKIAA1747", "protein_names_uniprotkb": "BMP/retinoic acid-inducible neural-specific protein 2", "protein_names_refseq": "BMP/retinoic acid-inducible neural-specific protein 2 precursor; BMP/retinoic acid-inducible neural-specific protein 2; family with sequence similarity 5, member B; protein FAM5B", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866)", "pathway": " (mmu:240843)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;20025061;21750661;30899004;33300544;37828378", "class_list": "", "function": "Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q80T96", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007399 nervous system development;GO:0045666 positive regulation of neuron differentiation;GO:0071300 cellular response to retinoic acid;GO:0035264 multicellular organism growth;GO:0045930 negative regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q6DFY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUE3-1", "uniprot_id": "C56D2_MOUSE", "mass": 24187.0, "length": 222, "protein_name": "Transmembrane reductase CYB561D2", "gene_name": "Cyb561d2", "organism": "Mouse", "refseq_name": "transmembrane reductase CYB561D2 isoform a", "refseq_ac": "NP_062694", "gene_names_uniprotkb": "Cyb561d2; 101f6", "gene_names_refseq": "Cyb561d2; Tsp10", "protein_names_uniprotkb": "Transmembrane reductase CYB561D2; 7.2.1.3; Cytochrome b561 domain-containing protein 2", "protein_names_refseq": "cytochrome b561 domain-containing protein 2; gene for 101F6 protein; putative tumor suppressor protein 101F6; transmembrane ascorbate ferrireductase; transmembrane reductase CYB561D2 isoform a; transmembrane reductase CYB561D2; tumor suppressor, region 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:56368)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17938141;19943161;21750661;31219806", "class_list": "", "function": "101F6 exhibited ferric as well as azo-dye-reductase activity., [RefSeq, PubMed]; Show (1) TSCytb's reduced spectra have a split a-band at already low ascorbate concentrations (at already high potential levels), and (2) it has two heme b redox centers, both with positive redox potentials, that differ by about 100 mV from each other, [RefSeq, PubMed]; Transmembrane reductase that may use ascorbate as an electron donor in the cytoplasm and transfer electrons across endoplasmic reticulum membranes to reduce monodehydro-L-ascorbate radical and iron cations Fe(3+) in the lumen of that compartment., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRQ1", "ec_number_list": "7.2.1.3", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0140575 transmembrane monodehydroascorbate reductase activity;GO:0140571 transmembrane ascorbate ferrireductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0031982 vesicle;GO:0016020 membrane", "go_biological_process": "GO:0140576 ascorbate homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WUE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHE5-1", "uniprot_id": "BMP3_MOUSE", "mass": 52774.0, "length": 468, "protein_name": "Bone morphogenetic protein 3", "gene_name": "Bmp3", "organism": "Mouse", "refseq_name": "bone morphogenetic protein 3 isoform 2 preproprotein", "refseq_ac": "NP_775580", "gene_names_uniprotkb": "Bmp3", "gene_names_refseq": "9530029I04Rik; Bmp3", "protein_names_uniprotkb": "Bone morphogenetic protein 3; BMP-3", "protein_names_refseq": "bone morphogenetic protein 3 isoform 2 preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:110075)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;11138004;21750661;22074949;30899004;35054971", "class_list": "", "function": "BMP3 Affects Cortical and Trabecular Long Bone Development in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentiation and ossification., [UniProtKB, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. Homozygous knockout mice for this gene exhibit increased bone density and volume, while overexpression of this gene in a transgenic mouse causes bone defects resulting in spontaneous rib fractures. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0070700 BMP receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031982 vesicle;GO:0005576 extracellular region", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:0001649 osteoblast differentiation;GO:0051216 cartilage development;GO:0030279 negative regulation of ossification", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BHE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJG7-1", "uniprot_id": "CABP8_MOUSE", "mass": 29625.0, "length": 261, "protein_name": "Calcium-binding protein 8", "gene_name": "Caln1", "organism": "Mouse", "refseq_name": "calcium-binding protein 8 isoform b", "refseq_ac": "NP_067346", "gene_names_uniprotkb": "Caln1; Cabp8; MNCb-0849", "gene_names_refseq": "9630012C17Rik; Cabp8; Caln1; MNCb-0849", "protein_names_uniprotkb": "Calcium-binding protein 8; CaBP8; Calneuron I; Calneuron-1", "protein_names_refseq": "calcium-binding protein 8 isoform b; calcium-binding protein 8; calneuron I", "tax_id": 10090, "disease": "", "pathway": " (mmu:140904)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11286509;21750661", "class_list": "", "function": "Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. May play a role in the physiology of neurons and is potentially important in memory and learning., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8WHE1", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0060291 long-term synaptic potentiation;GO:0007030 Golgi organization;GO:1990743 protein sialylation;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JJG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIF4-1", "uniprot_id": "BTD_MOUSE", "mass": 58154.0, "length": 520, "protein_name": "Biotinidase", "gene_name": "Btd", "organism": "Mouse", "refseq_name": "biotinidase isoform 1 precursor", "refseq_ac": "NP_079571", "gene_names_uniprotkb": "Btd", "gene_names_refseq": "Btd", "protein_names_uniprotkb": "Biotinidase; 3.5.1.12; Biotinase", "protein_names_refseq": "biotinase; biotinidase isoform 1 precursor", "tax_id": 10090, "disease": "biotinidase deficiency (Disease Ontology:DOID:856)", "pathway": " (mmu:26363); (R-MMU-196780)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12372635;16944957;21750661;22579707;24075304;26495903;30084848;30899004;32152506;40997131", "class_list": "", "function": "Biotinidase knockout mice show cellular energy deficit and altered carbon metabolism gene expression similar to that of nutritional biotin deprivation., [RefSeq, PubMed]; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results indicate low expression of biotinidase throughout the brain, but increased concentrations within the dorsal cochlear nucleus, ventral cochlear nucleus, and superior olivary complex as well as in the hair cells and spiral ganglion of the cochlea, [RefSeq, PubMed]; This study demonistrated that biotinidase deficiency mice showed demylination and axonal degeneration., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3UXQ4;Q9DAV0", "ec_number_list": "3.5.1.12", "go_molecular_function": "GO:0047708 biotinidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005730 nucleolus;GO:0043204 perikaryon;GO:0045177 apical part of cell", "go_biological_process": "GO:0006768 biotin metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8CIF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64277-1", "uniprot_id": "BST1_MOUSE", "mass": 34616.0, "length": 311, "protein_name": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2", "gene_name": "Bst1", "organism": "Mouse", "refseq_name": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor", "refseq_ac": "NP_033893", "gene_names_uniprotkb": "Bst1; Bp-3; Bp3; Ly65", "gene_names_refseq": "114/A10; A530073F09; BP-3; Bp3; Bst1; Bsta1; CD157; Ly65", "protein_names_uniprotkb": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; 3.2.2.6; ADP-ribosyl cyclase 2; Antigen BP3; BP-3 alloantigen; BST-1; Bone marrow stromal antigen 1; Cyclic ADP-ribose hydrolase 2; Leukocyte antigen 65; Ly-65; cADPR hydrolase 2", "protein_names_refseq": "ADP-ribosyl cyclase 2; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; BP-3 alloantigen; BST-1; antigen BP3; bone marrow stromal antigen 1; cADPr hydrolase 2; leukocyte antigen 65; ly-65", "tax_id": 10090, "disease": "", "pathway": " (mmu:12182); (R-MMU-163125); (R-MMU-196807); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;33326496;37969103;7819143;7916574", "class_list": "", "function": "Bone marrow stromal cell antigen-1 deficiency protects from acute kidney injury., [RefSeq, PubMed]; Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR). Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium. May be involved in pre-B-cell growth., [UniProtKB, UniProtKB]; Distinct physical condition and social behavior phenotypes of CD157 and CD38 knockout mice during aging. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BRY3", "ec_number_list": "2.3.2.27;7.6.2.1;3.4.11.9;3.1.3.48;3.1.3.1;1.14.19.17;5.2.1.-;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.4.24.81;3.2.2.5;2.4.2.31;2.7.11.1;1.14.14.18;3.1.4.50;3.4.21.73;3.9.1.1;3.2.2.6;2.4.99.20;3.2.2.-;3.6.5.2;1.1.1.-;3.4.24.-;2.3.1.78;1.6.3.-;3.4.17.12;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;2.3.1.51;3.4.21.-;3.5.1.92;3.1.4.4;2.3.1.20;2.3.1.76", "go_molecular_function": "GO:0016740 transferase activity;GO:0016849 phosphorus-oxygen lyase activity;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001931 uropod;GO:0098552 side of membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0032956 regulation of actin cytoskeleton organization;GO:0030890 positive regulation of B cell proliferation;GO:0050727 regulation of inflammatory response;GO:0001952 regulation of cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q64277-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923D2-1", "uniprot_id": "BLVRB_MOUSE", "mass": 22197.0, "length": 206, "protein_name": "Flavin reductase (NADPH)", "gene_name": "Blvrb", "organism": "Mouse", "refseq_name": "flavin reductase (NADPH) isoform 1", "refseq_ac": "NP_659172", "gene_names_uniprotkb": "Blvrb; Scan", "gene_names_refseq": "Blvrb", "protein_names_uniprotkb": "Flavin reductase (NADPH); 1.3.1.-; 1.5.1.30; 2.6.99.-; BVR-B; Biliverdin reductase B; Biliverdin-IX beta-reductase; FLR; FR; NADPH-dependent diaphorase; NADPH-flavin reductase; S-nitroso-CoA-assisted nitrosyltransferase; SNO-CoA-assisted nitrosyltransferase", "protein_names_refseq": "BVR-B; FLR; FR; NADPH-dependent diaphorase; NADPH-flavin reductase; S-nitroso-CoA-assisted nitrosyltransferase; SNO-CoA-assisted nitrosyltransferase; biliverdin-IX beta-reductase; flavin reductase (NADPH) isoform 1; flavin reductase (NADPH)", "tax_id": 10090, "disease": "", "pathway": " (mmu:233016); (R-MMU-189483); (R-MMU-9707564)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "21750661;25428506;25605945;30779550;33359909;34428180;37371462;37507081;38056462", "class_list": "", "function": "Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in Patients with Symptomatic Carotid Atherosclerosis. Publication Status: Online-Only, [RefSeq, PubMed]; Divergent erythroid megakaryocyte fates in Blvrb-deficient mice establish non-overlapping cytoprotective functions during stress hematopoiesis., [RefSeq, PubMed]; Enzyme that can both act as a NAD(P)H-dependent reductase and a S-nitroso-CoA-dependent nitrosyltransferase (PubMed:38056462). Promotes fetal heme degradation during development (By similarity). Also expressed in adult tissues, where it acts as a regulator of hematopoiesis, intermediary metabolism (glutaminolysis, glycolysis, TCA cycle and pentose phosphate pathway) and insulin signaling (PubMed:33359909, PubMed:38056462). Has a broad specificity oxidoreductase activity by catalyzing the NAD(P)H-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone) (By similarity). Contributes to fetal heme catabolism by catalyzing reduction of biliverdin IXbeta into bilirubin IXbeta in the liver (By similarity). Biliverdin IXbeta, which constitutes the major heme catabolite in the fetus is not present in adult (By similarity). Does not reduce bilirubin IXalpha (By similarity). Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH (By similarity). Acts as a protein nitrosyltransferase by catalyzing nitrosylation of cysteine residues of target proteins, such as HMOX2, INSR and IRS1 (PubMed:38056462). S-nitroso-CoA-dependent nitrosyltransferase activity is mediated via a 'ping-pong' mechanism: BLVRB first associates with both S-nitroso-CoA and protein substrate, nitric oxide group is then transferred from S-nitroso-CoA to Cys-109 and Cys-188 residues of BLVRB and from S-nitroso-BLVRB to the protein substrate (By similarity). Inhibits insulin signaling by mediating nitrosylation of INSR and IRS1, leading to their inhibition (PubMed:38056462)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.3.1.-;2.6.99.-;1.5.1.30;1.3.1.24", "go_molecular_function": "GO:0035605 peptidyl-cysteine S-nitrosylase activity;GO:0004074 biliverdin reductase [NAD(P)H] activity;GO:0042602 riboflavin reductase (NADPH) activity;GO:0052873 FMN reductase (NADPH) activity;GO:0052874 FMN reductase (NADH) activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043195 terminal bouton", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0001708 cell fate specification;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:1903409 reactive oxygen species biosynthetic process;GO:0030218 erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q923D2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CJ69-1", "uniprot_id": "BMPER_MOUSE", "mass": 76148.0, "length": 685, "protein_name": "BMP-binding endothelial regulator protein", "gene_name": "Bmper", "organism": "Mouse", "refseq_name": "BMP-binding endothelial regulator protein precursor", "refseq_ac": "NP_082748", "gene_names_uniprotkb": "Bmper; Cv2", "gene_names_refseq": "3110056H04Rik; Bmper; CV-2; Crim3; Cv2", "protein_names_uniprotkb": "BMP-binding endothelial regulator protein; Bone morphogenetic protein-binding endothelial cell precursor-derived regulator; Protein crossveinless-2; mCV2", "protein_names_refseq": "BMP-binding endothelial regulator protein precursor; BMP-binding endothelial regulator protein; bone morphogenetic protein-binding endothelial cell precursor-derived regulator; crossveinless-2", "tax_id": 10090, "disease": "opiate dependence (Disease Ontology:DOID:2559)", "pathway": " (mmu:73230)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12897139;14516682;15188429;17035289;21750661;37311809", "class_list": "", "function": "BMPER is a marker of adipose progenitors and adipocytes and a positive modulator of adipogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Crossveinless 2 has essential pro-Bmp functions for locally restricted signal enhancement in multiple aspects of mammalian organogenesis., [RefSeq, PubMed]; Cv2 is a conserved, positive regulator of bone morphogenetic protein signaling. Its cysteine-rich domains acts as both positive and negative modulators of BMP signaling., [RefSeq, PubMed]; Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes., [UniProtKB]; This gene encodes a secreted protein that contains five Von Willebrand factor type C domains and a Von Willebrand factor type D domain and a trypsin inhibitory-like domain. The encoded protein binds to bone morphogenetic proteins (BMP) and regulates their activity. Mutation of the related gene in humans causes diaphanospondylodysostosis. [provided by RefSeq, Mar 2013]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q7TN57;Q80UZ1;Q9CXM8", "ec_number_list": "", "go_molecular_function": "GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0032880 regulation of protein localization;GO:0001568 blood vessel development;GO:0030509 BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CJ69-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VC97-1", "uniprot_id": "BUP1_MOUSE", "mass": 43937.0, "length": 393, "protein_name": "Beta-ureidopropionase", "gene_name": "Upb1", "organism": "Mouse", "refseq_name": "beta-ureidopropionase", "refseq_ac": "NP_598756", "gene_names_uniprotkb": "Upb1", "gene_names_refseq": "Upb1", "protein_names_uniprotkb": "Beta-ureidopropionase; 3.5.1.6; Beta-alanine synthase; N-carbamoyl-beta-alanine amidohydrolase", "protein_names_refseq": "N-carbamoyl-beta-alanine amidohydrolase; beta-alanine synthase; beta-ureidopropionase", "tax_id": 10090, "disease": "", "pathway": " (mmu:103149); (R-MMU-73621)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;34428180;8449931", "class_list": "", "function": "Catalyzes a late step in pyrimidine degradation. Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide. Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide., [UniProtKB, UniProtKB]; Cloning and characterization of rat ortholog, [RefSeq, PubMed]; This gene encodes an enzyme that catalyzes the conversion of N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to beta-aminoisobutyric acid or beta-alanine. Mutations in the related gene in human have been associated with beta-ureidopropionase deficiency. [provided by RefSeq, Dec 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1K8", "ec_number_list": "3.5.1.6", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0003837 beta-ureidopropionase activity;GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0001889 liver development;GO:0051260 protein homooligomerization;GO:0051289 protein homotetramerization;GO:0019482 beta-alanine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VC97-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXP7-1", "uniprot_id": "C1QT1_MOUSE", "mass": 32009.0, "length": 281, "protein_name": "Complement C1q tumor necrosis factor-related protein 1", "gene_name": "C1qtnf1", "organism": "Mouse", "refseq_name": "complement C1q tumor necrosis factor-related protein 1 precursor", "refseq_ac": "NP_001191058", "gene_names_uniprotkb": "C1qtnf1; Zsig37", "gene_names_refseq": "1600017K21Rik; Adip; C1qtnf1; CTRP1; Zsig37", "protein_names_uniprotkb": "Complement C1q tumor necrosis factor-related protein 1; Putative secreted protein ZSIG37", "protein_names_refseq": "adiponectin p; complement C1q tumor necrosis factor-related protein 1 precursor; complement C1q tumor necrosis factor-related protein 1; putative secreted protein ZSIG37", "tax_id": 10090, "disease": "", "pathway": " (mmu:56745)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;15231994;21750661;22086915;34025643;34837016", "class_list": "", "function": "CTRP1 Aggravates Cardiac Dysfunction Post Myocardial Infarction by Modulating TLR4 in Macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; CTRP1 is a novel regulator of fatty acid metabolism., [RefSeq, PubMed]; ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9462, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80VI9", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0010628 positive regulation of gene expression;GO:0043410 positive regulation of MAPK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0010906 regulation of glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QXP7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q924Y0-1", "uniprot_id": "BODG_MOUSE", "mass": 44699.0, "length": 387, "protein_name": "Gamma-butyrobetaine dioxygenase", "gene_name": "Bbox1", "organism": "Mouse", "refseq_name": "gamma-butyrobetaine dioxygenase", "refseq_ac": "NP_569719", "gene_names_uniprotkb": "Bbox1", "gene_names_refseq": "Bbox1", "protein_names_uniprotkb": "Gamma-butyrobetaine dioxygenase; 1.14.11.1; Gamma-BBH; Gamma-butyrobetaine hydroxylase; Gamma-butyrobetaine,2-oxoglutarate dioxygenase", "protein_names_refseq": "butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase); gamma-BBH; gamma-butyrobetaine dioxygenase; gamma-butyrobetaine hydroxylase; gamma-butyrobetaine,2-oxoglutarate dioxygenase", "tax_id": 10090, "disease": "", "pathway": " (mmu:170442); (R-MMU-71262)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21549104;21750661;29065368;34428180;34887587", "class_list": "", "function": "BBOX 1 expression was increased in the medial frontal cortex of a mouse model of schizophrenia induced by maternal immune activation., [RefSeq, PubMed]; Catalyzes the formation of L-carnitine from gamma-butyrobetaine., [UniProtKB, UniProtKB]; Study clearly shows that mouse gamma-butyrobetaine dioxygenase is a direct PPARalpha target gene, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.11.1", "go_molecular_function": "GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0008336 gamma-butyrobetaine dioxygenase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0045329 carnitine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q924Y0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1A6-1", "uniprot_id": "C2D1A_MOUSE", "mass": 103698.0, "length": 943, "protein_name": "Coiled-coil and C2 domain-containing protein 1A", "gene_name": "Cc2d1a", "organism": "Mouse", "refseq_name": "coiled-coil and C2 domain-containing protein 1A isoform 1", "refseq_ac": "NP_666082", "gene_names_uniprotkb": "Cc2d1a", "gene_names_refseq": "Cc2d1a; Freud-1; Tape", "protein_names_uniprotkb": "Coiled-coil and C2 domain-containing protein 1A; FRE under dual repression-binding protein 1; Five prime repressor element under dual repression-binding protein 1; Freud-1", "protein_names_refseq": "5-HT1A receptor; FRE under dual repression-binding protein 1; coiled-coil and C2 domain-containing protein 1A isoform 1; coiled-coil and C2 domain-containing protein 1A; five prime repressor element under dual repression-binding protein 1; five' repressor element under dual repression binding protein 1; putative NFkB activating protein", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); syndromic intellectual disability (Disease Ontology:DOID:0050888); ciliopathy (Disease Ontology:DOID:0060340); autosomal recessive intellectual developmental disorder 3 (Disease Ontology:DOID:0081179); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:212139)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "12917378;14756806;16033914;17084358;17535813;19144319;21183079;21273312;21750661;25605945;26495903;29187734;34428180;37059290;39334949;40885482", "class_list": "", "function": "Autism-Related Cc2d1a Heterozygous Mice: Increased Levels of miRNAs Retained in DNA/RNA Hybrid Profiles (R-Loop). Publication Status: Online-Only, [RefSeq, PubMed]; Freud-1 has a key role in regulating DRD2 expression, [RefSeq, PubMed]; Heterozygous Cc2d1a mice show sex-dependent changes in the Beclin-1/p62 ratio with impaired prefrontal cortex and hippocampal autophagy., [RefSeq, PubMed]; Novel calcium-regulated repressor that negatively regulates basal 5-HT1A receptor expression., [RefSeq, PubMed]; Paper describes a function of Cc2d1a/Cc2d1b and its Drosophila homologue l(2)gd in D.melanogaster in Notch trafficking., [RefSeq, PubMed]; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q2MJB5;Q8R3Z4", "ec_number_list": "", "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0002087 regulation of respiratory gaseous exchange by nervous system process;GO:0140059 dendrite arborization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8K1A6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D211-1", "uniprot_id": "C2AIL_MOUSE", "mass": 13209.0, "length": 116, "protein_name": "CDKN2AIP N-terminal-like protein", "gene_name": "Cdkn2aipnl", "organism": "Mouse", "refseq_name": "CDKN2AIP N-terminal-like protein", "refseq_ac": "NP_084252", "gene_names_uniprotkb": "Cdkn2aipnl; D11Ertd497e; MNCb-1520", "gene_names_refseq": "A430101B06Rik; Cdkn2aipnl; D11Ertd497e; MNCb-1520; Xtbd1", "protein_names_uniprotkb": "CDKN2AIP N-terminal-like protein; CDKN2A-interacting protein N-terminal-like protein", "protein_names_refseq": "CDKN2A interacting protein N-terminal like; CDKN2A-interacting protein N-terminal-like protein; CDKN2AIP N-terminal-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:52626)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AU49", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D211-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JMK0-1", "uniprot_id": "B4GT5_MOUSE", "mass": 44814.0, "length": 388, "protein_name": "Beta-1,4-galactosyltransferase 5", "gene_name": "B4galt5", "organism": "Mouse", "refseq_name": "beta-1,4-galactosyltransferase 5", "refseq_ac": "NP_062809", "gene_names_uniprotkb": "B4galt5; Bgt-5", "gene_names_refseq": "9430078I07Rik; B4galt5", "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase 5; 2.4.1.-; 2.4.1.274; Beta-1,4-GalT II; Beta-1,4-GalTase 5; Beta4Gal-T5; Glucosylceramide beta-1,4-galactosyltransferase; LacCer synthase; Lactosylceramide synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5; b4Gal-T5", "protein_names_refseq": "UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5; b4Gal-T5; beta-1,4-GalT II; beta-1,4-GalTase 5; beta-1,4-galactosyltransferase 5; beta-1,4-galactosyltransferase V; beta4Gal-T5; glucosylceramide beta-1,4-galactosyltransferase; lacCer synthase; lactosylceramide synthase", "tax_id": 10090, "disease": "multiple sclerosis (Disease Ontology:DOID:2377)", "pathway": " (mmu:56336); (R-MMU-2022854); (R-MMU-913709); (R-MMU-975577); (R-MMU-9840309)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11145975;19114028;20574042;21057870;21750661;23882130;29415997;29984736;30114188;35820727;37828378;38081351;39927985", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:21057870, PubMed:23882130, PubMed:30114188). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (PubMed:30114188). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (PubMed:29415997). Essential for extraembryonic development during early embryogenesis (PubMed:20574042, PubMed:21057870)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Downregulation of B4GALT5 attenuates cardiac fibrosis through Lumican and Akt/GSK-3beta/beta-catenin pathway., [RefSeq, PubMed]; Lactosylceramide synthase is encoded by B4galt5 and 6 genes in the central nervous system, and these genes are indispensable for neuronal maturation, perineuronal nets formation, and axonal and myelin formation. Publication Status: Online-Only, [RefSeq, PubMed]; The expression of Beta4GalT5 gene decreases through reduced expression of the Sp1 gene and protein upon differentiation of pre-adipocytes to adipocytes., [RefSeq, PubMed]; The results indicate that the growth is delayed by one to one and half day in B4galt5-/- embryos when compared to B4galt5+/- embryos, which results in early death of the embryos by E10.5, probably due to hematopoietic and/or placental defects., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A2A5T7", "ec_number_list": "2.4.1.-;2.4.1.275;2.4.1.22;2.4.1.38;2.4.1.90;2.4.1.274", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity;GO:0003945 N-acetyllactosamine synthase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0022010 central nervous system myelination;GO:0005975 carbohydrate metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0031647 regulation of protein stability;GO:0040019 positive regulation of embryonic development", "synthesized_glycan_count": 2205, "hit_score": 2.0, "record_id": "Q9JMK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWU4-1", "uniprot_id": "CA052_MOUSE", "mass": 20101.0, "length": 180, "protein_name": "UPF0690 protein C1orf52 homolog", "gene_name": "2410004B18Rik", "organism": "Mouse", "refseq_name": "UPF0690 protein C1orf52 homolog isoform 1", "refseq_ac": "NP_079831", "gene_names_uniprotkb": "2410004B18Rik", "gene_names_refseq": "2410004B18Rik; 4930572C24Rik", "protein_names_uniprotkb": "UPF0690 protein C1orf52 homolog", "protein_names_refseq": "UPF0690 protein C1orf52 homolog isoform 1; UPF0690 protein C1orf52 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66421)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17242355;19131326;21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CRP5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CWU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8U4-1", "uniprot_id": "C1QT2_MOUSE", "mass": 30865.0, "length": 294, "protein_name": "Complement C1q tumor necrosis factor-related protein 2", "gene_name": "C1qtnf2", "organism": "Mouse", "refseq_name": "complement C1q tumor necrosis factor-related protein 2 isoform X1", "refseq_ac": "XP_036012851", "gene_names_uniprotkb": "C1qtnf2; Crtp2", "gene_names_refseq": "1810033K05Rik; Adih; C1qtnf2; CTRP2", "protein_names_uniprotkb": "Complement C1q tumor necrosis factor-related protein 2; mCTRP2", "protein_names_refseq": "complement C1q tumor necrosis factor-related protein 2 isoform X1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69183)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;15231994;21750661;22351773;31439668;34428180", "class_list": "", "function": "Involved in the regulation of lipid metabolism in adipose tissue and liver., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex;GO:0005576 extracellular region", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0019216 regulation of lipid metabolic process;GO:0045725 positive regulation of glycogen biosynthetic process;GO:0046326 positive regulation of D-glucose import;GO:0046321 positive regulation of fatty acid oxidation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D8U4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9J8-1", "uniprot_id": "BPIA3_MOUSE", "mass": 25713.0, "length": 232, "protein_name": "BPI fold-containing family A member 3", "gene_name": "Bpifa3", "organism": "Mouse", "refseq_name": "BPI fold-containing family A member 3 isoform b precursor", "refseq_ac": "NP_001278008", "gene_names_uniprotkb": "Bpifa3; Splunc3", "gene_names_refseq": "1700058C13Rik; Bpifa3; Splunc3", "protein_names_uniprotkb": "BPI fold-containing family A member 3; Short palate, lung and nasal epithelium carcinoma-associated protein 3", "protein_names_refseq": "BPI fold-containing family A member 3 isoform b precursor; Novel LBP / BPI / CETP family, N-terminal domain containing protein; short palate, lung and nasal epithelium carcinoma-associated protein 3 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:73388)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D9J8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5EBG8-1", "uniprot_id": "CA050_MOUSE", "mass": 21863.0, "length": 199, "protein_name": "Uncharacterized protein C1orf50 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C1orf50 homolog isoform 1", "refseq_ac": "NP_001012400", "gene_names_uniprotkb": "", "gene_names_refseq": "230696; AU022252", "protein_names_uniprotkb": "Uncharacterized protein C1orf50 homolog", "protein_names_refseq": "uncharacterized protein C1orf50 homolog isoform 1; uncharacterized protein C1orf50 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:230696)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "28528544", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5EBG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RJF7-1", "uniprot_id": "CA2D4_MOUSE", "mass": 125991.0, "length": 1116, "protein_name": "Voltage-dependent calcium channel subunit alpha-2/delta-4", "gene_name": "Cacna2d4", "organism": "Mouse", "refseq_name": "voltage-dependent calcium channel subunit alpha-2/delta-4 isoform 1 precursor", "refseq_ac": "NP_001028554", "gene_names_uniprotkb": "Cacna2d4", "gene_names_refseq": "5730412N02Rik; Cacna2d4", "protein_names_uniprotkb": "Voltage-dependent calcium channel subunit alpha-2/delta-4; Voltage-gated calcium channel subunit alpha-2/delta-4", "protein_names_refseq": "voltage-dependent calcium channel subunit alpha-2/delta-4 isoform 1 precursor; voltage-dependent calcium channel subunit alpha-2/delta-4; voltage-gated calcium channel subunit alpha-2/delta-4", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); retinal cone dystrophy 4 (Disease Ontology:DOID:0081023); heart conduction disease (Disease Ontology:DOID:10273)", "pathway": " (mmu:319734)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15536090;16877424;21750661;34428180", "class_list": "", "function": "The Cacna2d4 mutation underlies a novel channelopathy leading to cone-rod dysfunction in the visual system of mice, [RefSeq, PubMed]; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0005891 voltage-gated calcium channel complex", "go_biological_process": "GO:0070588 calcium ion transmembrane transport;GO:0050908 detection of light stimulus involved in visual perception", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5RJF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SUD9-1", "uniprot_id": "BBS12_MOUSE", "mass": 78335.0, "length": 708, "protein_name": "Chaperonin-containing T-complex member BBS12", "gene_name": "Bbs12", "organism": "Mouse", "refseq_name": "chaperonin-containing T-complex member BBS12 isoform 1", "refseq_ac": "NP_001008502", "gene_names_uniprotkb": "Bbs12; Gm1805", "gene_names_refseq": "Bbs12; Gm1805; Gm407; Gm721", "protein_names_uniprotkb": "Chaperonin-containing T-complex member BBS12; Bardet-Biedl syndrome 12 protein homolog", "protein_names_refseq": "Bardet-Biedl syndrome 12 protein homolog; chaperonin-containing T-complex member BBS12 isoform 1; chaperonin-containing T-complex member BBS12", "tax_id": 10090, "disease": "Bardet-Biedl syndrome 12 (Disease Ontology:DOID:0110134)", "pathway": " (mmu:241950); (R-MMU-5620922)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;22958920;25428506;37828378", "class_list": "", "function": "Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation., [UniProtKB, UniProtKB]; Despite increased obesity, glucose tolerance was increased with specific enhanced insulin sensitivity in the adipocytes of Bbs12 knockout mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AGT2", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0005929 cilium", "go_biological_process": "GO:0042755 eating behavior;GO:0045494 photoreceptor cell maintenance;GO:0045599 negative regulation of fat cell differentiation;GO:0042073 intraciliary transport;GO:0051131 chaperone-mediated protein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5SUD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64152-1", "uniprot_id": "BTF3_MOUSE", "mass": 22031.0, "length": 204, "protein_name": "Transcription factor BTF3", "gene_name": "Btf3", "organism": "Mouse", "refseq_name": "transcription factor BTF3 isoform 2", "refseq_ac": "NP_001164011", "gene_names_uniprotkb": "Btf3", "gene_names_refseq": "1700054E11Rik; Btf3", "protein_names_uniprotkb": "Transcription factor BTF3; NAC-beta; Nascent polypeptide-associated complex subunit beta; RNA polymerase B transcription factor 3", "protein_names_refseq": "NAC-beta; RNA polymerase B transcription factor 3; nascent polypeptide-associated complex subunit beta; transcription factor BTF3 isoform 2; transcription factor BTF3", "tax_id": 10090, "disease": "", "pathway": " (mmu:218490)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "16452087;16479539;18250455;18288386;24129315;25428506;28011936;28935714;30779550;31361958;33602894;34418053;34428180;35820727;35984892;37453647;37507081;37828378;7655515", "class_list": "", "function": "Six putative caspase substrates, including five novel proteins (ABCF1, AKAP1, CPE, DOPEY1 and GOPC1) that may be targeted specifically by the initiator caspases 8 and 10 during the early stages of apoptosis, were identified.[caspase 10], [RefSeq, PubMed]; Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity. Erratum:[Signal Transduct Target Ther. 2021 Mar 12;6(1):120. doi: 10.1038/s41392-021-00533-3. PMID: 33712568] Publication Status: Online-Only, [RefSeq, PubMed]; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q64153;Q6GU63;Q6P3F3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005854 nascent polypeptide-associated complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0015031 protein transport;GO:1905551 negative regulation of protein localization to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q64152-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PHS9-1", "uniprot_id": "CA2D2_MOUSE", "mass": 130385.0, "length": 1154, "protein_name": "Voltage-dependent calcium channel subunit alpha-2/delta-2", "gene_name": "Cacna2d2", "organism": "Mouse", "refseq_name": "voltage-dependent calcium channel subunit alpha-2/delta-2 isoform 1 precursor", "refseq_ac": "NP_001167518", "gene_names_uniprotkb": "Cacna2d2; Kiaa0558", "gene_names_refseq": "Cacna2d2; Cacna2d; a2d2; du; mKIAA0558; td; torpid", "protein_names_uniprotkb": "Voltage-dependent calcium channel subunit alpha-2/delta-2; Protein ducky; Voltage-gated calcium channel subunit alpha-2/delta-2", "protein_names_refseq": "alpha 2 delta calcium channel subunit; protein ducky; voltage-dependent calcium channel alpha2/delta-2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform 1 precursor; voltage-dependent calcium channel subunit alpha-2/delta-2; voltage-gated calcium channel subunit alpha-2/delta-2", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); heart conduction disease (Disease Ontology:DOID:10273); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:56808); (R-MMU-112308); (R-MMU-422356); (R-MMU-5576892); (R-MMU-5576893)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10762351;10766861;11130987;11306709;11487633;11756448;14660671;15331424;16061813;16928863;17052222;17135419;30899004;33300544;34428180;38749701", "class_list": "", "function": "Altered Hippocampal Activation in Seizure-Prone CACNA2D2 Knock-out Mice. Publication Status: Online-Only, [RefSeq, PubMed]; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 10, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 10, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 10, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 20, "disease_count": 3, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "B2RY16;Q3TPT9;Q3TSS6;Q6REE3;Q8C8R8;Q8CHE9;Q920H5;Q920H6;Q9EQG2;Q9R142", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0005891 voltage-gated calcium channel complex", "go_biological_process": "GO:0060024 rhythmic synaptic transmission;GO:0007528 neuromuscular junction development;GO:0040014 regulation of multicellular organism growth;GO:0006816 calcium ion transport;GO:0046622 positive regulation of organ growth", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "Q6PHS9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80ZU7-1", "uniprot_id": "BPIB3_MOUSE", "mass": 49885.0, "length": 473, "protein_name": "BPI fold-containing family B member 3", "gene_name": "Bpifb3", "organism": "Mouse", "refseq_name": "BPI fold-containing family B member 3 precursor", "refseq_ac": "NP_919338", "gene_names_uniprotkb": "Bpifb3; Lplunc3; Rya3", "gene_names_refseq": "Bpifb3; Lplunc3; Rya3", "protein_names_uniprotkb": "BPI fold-containing family B member 3; Ligand-binding protein RYA3; Long palate, lung and nasal epithelium carcinoma-associated protein 3", "protein_names_refseq": "BPI fold-containing family B member 3 precursor; antimicrobial peptide RYA3; ligand-binding protein RYA3; long palate, lung and nasal epithelium carcinoma-associated protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:378700)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2APD1", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q80ZU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BP99-1", "uniprot_id": "CA216_MOUSE", "mass": 25232.0, "length": 230, "protein_name": "UPF0500 protein C1orf216 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "UPF0500 protein C1orf216 homolog", "refseq_ac": "NP_001013777", "gene_names_uniprotkb": "", "gene_names_refseq": "5730409E04Rik; 7530403E16Rik", "protein_names_uniprotkb": "UPF0500 protein C1orf216 homolog", "protein_names_refseq": "UPF0500 protein C1orf216 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:230757)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A7K4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BP99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BR07-1", "uniprot_id": "BICD1_MOUSE", "mass": 95896.0, "length": 835, "protein_name": "Protein bicaudal D homolog 1", "gene_name": "Bicd1", "organism": "Mouse", "refseq_name": "protein bicaudal D homolog 1 isoform 1", "refseq_ac": "NP_001106267", "gene_names_uniprotkb": "Bicd1", "gene_names_refseq": "B830009D06Rik; Bicd1; bic-D 1", "protein_names_uniprotkb": "Protein bicaudal D homolog 1; Bic-D 1", "protein_names_refseq": "protein bicaudal D homolog 1 isoform 1; protein bicaudal D homolog 1", "tax_id": 10090, "disease": "spinal muscular atrophy with lower extremity predominant 2A (Disease Ontology:DOID:0070349)", "pathway": " (mmu:12121); (R-MMU-6811436)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;22872234;24920579;25428506;25796327;30084848;32079660;9367685", "class_list": "", "function": "BICD1 regulates neurotrophin signalling by modulating the endosomal sorting of internalised ligand-activated receptors., [RefSeq, PubMed]; Findings suggest a molecular basis for cargo recognition and autoinhibition of BICD proteins during dynein-dependent intracellular retrograde transport, [RefSeq, PubMed]; PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55206;Q8BQ18;Q8BRR8;Q8C4D3;Q8CAK6;Q8R2J4;Q8R2J5;Q8R2J6;Q91YP7", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0008093 cytoskeletal anchor activity;GO:0031267 small GTPase binding;GO:0070840 dynein complex binding;GO:0034452 dynactin binding", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:1904781 positive regulation of protein localization to centrosome;GO:0048260 positive regulation of receptor-mediated endocytosis;GO:0019068 virion assembly;GO:0034063 stress granule assembly;GO:0070507 regulation of microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BR07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C1E1-1", "uniprot_id": "BPIB2_MOUSE", "mass": 49521.0, "length": 462, "protein_name": "BPI fold-containing family B member 2", "gene_name": "Bpifb2", "organism": "Mouse", "refseq_name": "BPI fold-containing family B member 2 precursor", "refseq_ac": "NP_079907", "gene_names_uniprotkb": "Bpifb2; Bpil1", "gene_names_refseq": "2310034L21Rik; 2310069A01Rik; Bpifb2; Bpil1; LPLUNC2; RYSR", "protein_names_uniprotkb": "BPI fold-containing family B member 2; Bactericidal/permeability-increasing protein-like 1", "protein_names_refseq": "BPI fold-containing family B member 2 precursor; bactericidal/permeability-increasing protein-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66557); (R-MMU-381426); (R-MMU-6803157); (R-MMU-8957275)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "25428506;30084848", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUY4;Q8BVZ0;Q8C1E2;Q9D713;Q9D744", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C1E1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFW7-1", "uniprot_id": "C2D2A_MOUSE", "mass": 187530.0, "length": 1633, "protein_name": "Coiled-coil and C2 domain-containing protein 2A", "gene_name": "Cc2d2a", "organism": "Mouse", "refseq_name": "coiled-coil and C2 domain-containing protein 2A isoform a", "refseq_ac": "NP_758478", "gene_names_uniprotkb": "Cc2d2a", "gene_names_refseq": "5730509K17Rik; Cc2d2a; b2b1035Clo", "protein_names_uniprotkb": "Coiled-coil and C2 domain-containing protein 2A", "protein_names_refseq": "coiled-coil and C2 domain-containing protein 2A isoform a; coiled-coil and C2 domain-containing protein 2A", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); Joubert syndrome (Disease Ontology:DOID:0050777); Meckel syndrome (Disease Ontology:DOID:0050778); ciliopathy (Disease Ontology:DOID:0060340); retinitis pigmentosa 93 (Disease Ontology:DOID:0061105); Meckel syndrome 6 (Disease Ontology:DOID:0070120); Joubert syndrome 9 (Disease Ontology:DOID:0111004); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:231214); (R-MMU-5620912)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21565611;21725307;21750661;22179047;24947469;38231387", "class_list": "", "function": "CC2D2A is essential for the assembly of subdistal appendages, which anchor cytoplasmic microtubules and prime the mother centriole for axoneme biogenesis Publication Status: Online-Only, [RefSeq, PubMed]; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling., [UniProtKB, PubMed, PubMed]; Joubert syndrome causing mutation in C2 domain of CC2D2A affects structural integrity of cilia and cellular signaling molecules., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BP57", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0036038 MKS complex;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0007507 heart development;GO:0001822 kidney development;GO:0001843 neural tube closure;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CFW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CJ91-1", "uniprot_id": "C209B_MOUSE", "mass": 37112.0, "length": 325, "protein_name": "CD209 antigen-like protein B", "gene_name": "Cd209b", "organism": "Mouse", "refseq_name": "CD209 antigen-like protein B isoform b", "refseq_ac": "NP_001032889", "gene_names_uniprotkb": "Cd209b", "gene_names_refseq": "1810030I22Rik; Cd209b; DC-SIGNR1; OtB7; SIGNR1; mSIGNR1", "protein_names_uniprotkb": "CD209 antigen-like protein B; DC-SIGN-related protein 1; DC-SIGNR1; OtB7", "protein_names_refseq": "CD209 antigen-like protein B isoform b; CD209 antigen-like protein B; DC-SIGN-related protein 1", "tax_id": 10090, "disease": "extrapulmonary tuberculosis (Disease Ontology:DOID:0050598); rheumatic heart disease (Disease Ontology:DOID:0050827); Coronavirus infectious disease (Disease Ontology:DOID:0080599); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); dengue disease (Disease Ontology:DOID:12205); dengue hemorrhagic fever (Disease Ontology:DOID:12206); aspergillosis (Disease Ontology:DOID:13564); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); tuberculosis (Disease Ontology:DOID:399); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:69165)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11581173;11581396;12137941;12351402;14707091;25450767", "class_list": "glycogene", "function": "Dendritic cell-specific ICAM-3-grabbing nonintegrin homolog SIGNR1 has been identified as a major mannose receptor for fungal and other pathogens present on murine resident peritoneal macrophages., [RefSeq, PubMed]; Isolation of a murine homologue of DC-SIGN that is identical to the previously reported murine homologue mSIGNR1; expressed in marginal zone macrophages, [RefSeq, PubMed]; Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGZ0;Q8BHK7;Q8CJ86;Q8CJ87;Q8CJ88;Q8CJ89;Q8CJ90;Q8CJ92;Q8CJ93;Q8CJ94;Q91ZW4;Q91ZX0;Q9D8V4", "ec_number_list": "", "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0046872 metal ion binding;GO:0048306 calcium-dependent protein binding;GO:0001618 virus receptor activity;GO:0005537 D-mannose binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0006955 immune response;GO:0016045 detection of bacterium;GO:0050766 positive regulation of phagocytosis;GO:0032760 positive regulation of tumor necrosis factor production", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CJ91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R079-1", "uniprot_id": "BFAR_MOUSE", "mass": 52968.0, "length": 450, "protein_name": "Bifunctional apoptosis regulator", "gene_name": "Bfar", "organism": "Mouse", "refseq_name": "bifunctional apoptosis regulator isoform 2", "refseq_ac": "NP_001171023", "gene_names_uniprotkb": "Bfar", "gene_names_refseq": "3010001A07Rik; 3110001I22Rik; Bar; Bfar; Rnf47", "protein_names_uniprotkb": "Bifunctional apoptosis regulator; 2.3.2.27", "protein_names_refseq": "bifunctional apoptosis regulator isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67118)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;34175335;34428180;38294943", "class_list": "", "function": "Membrane-bound E3 ubiquitin ligase that plays a role in several processes including apoptosis regulation or reticulum endoplasmic stress. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors. Contributes to the dynamic control of IRE1/ERN1 signaling during ER stress by inducing BAX inhibitor 1/TMBIM6 proteasomal degradation. Promotes the activation of TGF-beta signaling by mediating the 'Lys-63'-linked ubiquitination of TGFBR1 which is critical to activate the pathway. Together with NGFR, negatively regulates NF-kappa-B and JNK-related signaling pathways. Promotes the proteasome-mediated degradation of PNPLA3, a protein involveld in lipid metabolism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; The periphilin 1-like BFAR isoform 3 is highly expressed in transcriptionally silent oocytes and involved in RNA metabolism., [RefSeq, PubMed]; The ubiquitin E3 ligase BFAR promotes degradation of PNPLA3., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1A7;Q9CXY3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0061630 ubiquitin protein ligase activity;GO:0089720 caspase binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0036498 IRE1-mediated unfolded protein response;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R079-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1H8-1", "uniprot_id": "BATF2_MOUSE", "mass": 29703.0, "length": 277, "protein_name": "Basic leucine zipper transcriptional factor ATF-like 2", "gene_name": "Batf2", "organism": "Mouse", "refseq_name": "basic leucine zipper transcriptional factor ATF-like 2 isoform 1", "refseq_ac": "NP_083243", "gene_names_uniprotkb": "Batf2", "gene_names_refseq": "B-ATF-2; Batf2", "protein_names_uniprotkb": "Basic leucine zipper transcriptional factor ATF-like 2; B-ATF-2", "protein_names_refseq": "basic leucine zipper transcriptional factor ATF-like 2 isoform 1; basic leucine zipper transcriptional factor ATF-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74481)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22992524;25957166;26376615;37724373;37777155", "class_list": "", "function": "AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types. Possibly acts by interfering with AP-1 binding to CCN1 promoter (By similarity). Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes., [UniProtKB, PubMed]; BATF2 enhances proinflammatory cytokine responses in macrophages and improves early host defense against pulmonary Klebsiella pneumoniae infection., [RefSeq, PubMed]; BATF2 inhibits PD-L1 expression and regulates CD8+ T-cell infiltration in non-small cell lung cancer., [RefSeq, PubMed]; Batf2 has a central role in macrophage activation by regulating inflammatory responses during lipopolysaccharides stimulation and mycobacterial infection, [RefSeq, PubMed]; These results underline the role of Batf2/Irf1 in inducing inflammatory responses in M. tuberculosis infection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAI2", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042832 defense response to protozoan;GO:0043011 myeloid dendritic cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R1H8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2K8-1", "uniprot_id": "CA054_MOUSE", "mass": 16823.0, "length": 148, "protein_name": "Uncharacterized protein C1orf54 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C1orf54 homolog isoform 2 precursor", "refseq_ac": "NP_001333443", "gene_names_uniprotkb": "", "gene_names_refseq": "BC028528; L259", "protein_names_uniprotkb": "Uncharacterized protein C1orf54 homolog; Protein L259", "protein_names_refseq": "uncharacterized protein C1orf54 homolog isoform 2 precursor; uncharacterized protein C1orf54 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:229600)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3T8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R2K8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2Q8-1", "uniprot_id": "BST2_MOUSE", "mass": 19152.0, "length": 172, "protein_name": "Bone marrow stromal antigen 2", "gene_name": "Bst2", "organism": "Mouse", "refseq_name": "bone marrow stromal antigen 2", "refseq_ac": "NP_932763", "gene_names_uniprotkb": "Bst2", "gene_names_refseq": "2310015I10Rik; Bst-2; Bst2; CD317; DAMP-1; GREG", "protein_names_uniprotkb": "Bone marrow stromal antigen 2; BST-2; HM1.24 antigen", "protein_names_refseq": "DAMP-1 protein homolog; HM1.24 antigen; bone marrow stromal antigen 2; tetherin", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stomach cancer (Disease Ontology:DOID:10534); Sjogren's syndrome (Disease Ontology:DOID:12894); endometrial cancer (Disease Ontology:DOID:1380); malignant astrocytoma (Disease Ontology:DOID:3069); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); acquired immunodeficiency syndrome (Disease Ontology:DOID:635)", "pathway": " (mmu:69550); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;10329429;16920966;19179289;19349973;19903902;20686043;20702620;21084286;21919738;22025715;22284121;22327075;22645316;22811908;26495903;34428180;36604771;37143676;38360199;39627609", "class_list": "", "function": "BST2 resides within an intracellular compartment corresponding to the Golgi apparatus, and may be involved in trafficking secreted cytokines in type I IFN-producing cells, [RefSeq, PubMed]; Elevated cellular levels of BST-2 inhibited the release of virus-like particles consisting of the matrix proteins of multiple highly virulent NIAID Priority Pathogens, [RefSeq, PubMed]; IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Neuronal BST2: A Pruritic Mediator alongside Protease-Activated Receptor 2 in the IL-27-Driven Itch Pathway., [RefSeq, PubMed]; Promotion of BST2 expression by the transcription factor IRF6 affects the progression of endometriosis. Erratum:[Front Immunol. 2025 Dec 23;16:1748838. doi: 10.3389/fimmu.2025.1748838. PMID: 41503362] Publication Status: Online-Only, [RefSeq, PubMed]; Targeting BST-2 with 2 independent monoclonal antibodies delayed lymphoma growth in a syngeneic mouse model of the disease., [RefSeq, PubMed]; The roles of BST-2 in murine B cell development and on virus propagation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8CEY7", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0030336 negative regulation of cell migration;GO:0045071 negative regulation of viral genome replication", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8R2Q8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91YP1-1", "uniprot_id": "BN3D2_MOUSE", "mass": 32035.0, "length": 285, "protein_name": "RNA 5'-monophosphate methyltransferase", "gene_name": "Bcdin3d", "organism": "Mouse", "refseq_name": "RNA 5'-monophosphate methyltransferase", "refseq_ac": "NP_083512", "gene_names_uniprotkb": "Bcdin3d", "gene_names_refseq": "4930556P03Rik; Bcdin3d", "protein_names_uniprotkb": "RNA 5'-monophosphate methyltransferase; 2.1.1.-; BCDIN3 domain-containing protein", "protein_names_refseq": "BCDIN3 domain-containing protein; RNA 5'-monophosphate methyltransferase; pre-miRNA 5'-monophosphate methyltransferase; probable methyltransferase BCDIN3D", "tax_id": 10090, "disease": "", "pathway": " (mmu:75284)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1. Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D4U5", "ec_number_list": "2.1.1.-", "go_molecular_function": "GO:0090486 small RNA 2'-O-methyltransferase activity;GO:0008175 tRNA methyltransferase activity;GO:0008171 O-methyltransferase activity;GO:0070883 pre-miRNA binding;GO:0008173 RNA methyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0031054 pre-miRNA processing;GO:0030488 tRNA methylation;GO:0001510 RNA methylation;GO:2000632 negative regulation of pre-miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91YP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920P3-1", "uniprot_id": "BRNP1_MOUSE", "mass": 88641.0, "length": 760, "protein_name": "BMP/retinoic acid-inducible neural-specific protein 1", "gene_name": "Brinp1", "organism": "Mouse", "refseq_name": "BMP/retinoic acid-inducible neural-specific protein 1 precursor", "refseq_ac": "NP_064351", "gene_names_uniprotkb": "Brinp1; Brinp; Dbc1; Dbccr1; Fam5a", "gene_names_refseq": "BRINP; Brinp1; Dbc1; Dbccr1; Fam5a", "protein_names_uniprotkb": "BMP/retinoic acid-inducible neural-specific protein 1; Deleted in bladder cancer protein 1 homolog", "protein_names_refseq": "BMP/retinoic acid-inducible neural-specific protein (BRINP); BMP/retinoic acid-inducible neural-specific protein 1 precursor; BMP/retinoic acid-inducible neural-specific protein 1; deleted in bladder cancer chromosome region candidate 1; deleted in bladder cancer protein 1 homolog", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (mmu:56710)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;15193422;15193423;17141197;19088275;20025061;24528488;27042284;29960053;30899004;33300544;34428180", "class_list": "", "function": "Brinp1 plays an important role in normal brain development and function by influencing neuronal distribution within the cortex. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that neuron-restrictive silencing factor (NRSF) plays a role in the neural-selective expression of BMP/RA-inducible neural-specific protein 1., [RefSeq, PubMed]; From these results, the physiological roles of the activity-dependent induction of BRINP1-mRNA are discussed., [RefSeq, PubMed]; Plays a role in neurogenesis, brain development, and the functioning of GABAergic neurons (PubMed:24528488, PubMed:27042284, PubMed:29960053). May suppress cell cycle progression in postmitotic neurons by inhibiting G1/S transition (PubMed:15193423, PubMed:20025061, PubMed:24528488)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The authors show that retinoic acid-inducible gene (RIG)-I-like receptors (RLRs) in cooperation with Toll-like receptor (TLR) 9 is required for expression of type I interferons (IFNs) after infection with herpes simplex virus (HSV)., [RefSeq, PubMed]; The numbers of parvalbumin and somatostatin expressing neurons in the medial prefrontal cortex of BRINP1-knockout mice, were fewer compared to neurons in medial prefrontal cortex of wild-type mice., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZL2;Q812F0;Q8C1C9;Q920P4;Q9QXL0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:0008283 cell population proliferation;GO:0045666 positive regulation of neuron differentiation;GO:0071300 cellular response to retinoic acid;GO:0007614 short-term memory;GO:0035640 exploration behavior", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q920P3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q924M5-3", "uniprot_id": "BOLL_MOUSE", "mass": 32189.0, "length": 293, "protein_name": "Protein boule-like", "gene_name": "Boll", "organism": "Mouse", "refseq_name": "protein boule-like isoform 2", "refseq_ac": "NP_001106838", "gene_names_uniprotkb": "Boll; Boule", "gene_names_refseq": "4930554P13Rik; 4930597B14Rik; Boll", "protein_names_uniprotkb": "Protein boule-like", "protein_names_refseq": "bol, boule-like; protein boule-like isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:75388)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11390979;20335278;21183079;24086306;27632217", "class_list": "", "function": "Asked whether BOULE, the founding member of DAZ family proteins, is a component of the SGs. We show that BOULE is recruited to the SGs upon heat stress, and that these SGs are developmental stage-specific Publication Status: Online-Only, [RefSeq, PubMed]; Demonstrate that Boll is also transiently expressed during oogenesis in the fetal mouse ovary, but is simultaneously co-expressed within the same germ cells as Dazl Erratum:[PLoS One. 2015 Aug 13;10(8):e0136009. doi: 10.1371/journal.pone.0136009. PMID: 26270527] Publication Status: Online-Only, [RefSeq, PubMed]; Expression of key regulators of spermiogenesis was unaffected in Boule(-/-) mice, suggesting that Boule regulates germ-cell differentiation through a novel pathway., [RefSeq, PubMed]; Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QPQ9;Q9D4V2", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0008494 translation activator activity;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0070935 3'-UTR-mediated mRNA stabilization;GO:0051321 meiotic cell cycle;GO:0045948 positive regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q924M5-3", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99246-2", "uniprot_id": "CAC1D_MOUSE", "mass": 247061.0, "length": 2179, "protein_name": "Voltage-dependent L-type calcium channel subunit alpha-1D", "gene_name": "Cacna1d", "organism": "Mouse", "refseq_name": "voltage-dependent L-type calcium channel subunit alpha-1D isoform 2", "refseq_ac": "NP_001077085", "gene_names_uniprotkb": "Cacna1d; Cach3; Cacn4; Cacnl1a2; Cchl1a2", "gene_names_refseq": "8430418G19Rik; Cach3; Cacn4; Cacna1d; Cacnl1a2; Cav1.3; Cchl1a2; Cchl1a; D-LTCC", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit alpha-1D; Calcium channel, L type, alpha-1 polypeptide isoform 2; Voltage-gated calcium channel subunit alpha Cav1.3", "protein_names_refseq": "Cav1.3alpha1; alpha 1 E; calcium channel, L type, alpha-1 polypeptide; voltage-dependent L-type calcium channel subunit alpha-1D isoform 2; voltage-dependent L-type calcium channel subunit alpha-1D; voltage-gated calcium channel subunit alpha Cav1.3", "tax_id": 10090, "disease": "Timothy syndrome (Disease Ontology:DOID:0060173); sciatic neuropathy (Disease Ontology:DOID:11446); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); congenital heart disease (Disease Ontology:DOID:1682); schizophrenia (Disease Ontology:DOID:5419); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:12289); (R-MMU-422356)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10929716;11581302;12700358;12900400;16354915;17947313;2173707;25428506", "class_list": "", "function": "This gene encodes a pore-forming subunit of the L-type, voltage-activated calcium channel family. These channels have been found to play a role in heart and smooth muscle contraction and in the transmission of auditory information. Homozygous knockout mice for this gene exhibit deafness and heart defects. These channels have also been linked to mitochondrial oxidative stress in a mouse model of Parkinson's disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]., [RefSeq]; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 3, "disease_count": 6, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSD2;Q8R2I9;Q8R2J0", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0046872 metal ion binding;GO:0051393 alpha-actinin binding;GO:0030165 PDZ domain binding;GO:0030506 ankyrin binding", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043204 perikaryon;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0019722 calcium-mediated signaling;GO:0006816 calcium ion transport;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0051924 regulation of calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q99246-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D275-1", "uniprot_id": "BATF3_MOUSE", "mass": 13657.0, "length": 118, "protein_name": "Basic leucine zipper transcriptional factor ATF-like 3", "gene_name": "Batf3", "organism": "Mouse", "refseq_name": "basic leucine zipper transcriptional factor ATF-like 3", "refseq_ac": "NP_084336", "gene_names_uniprotkb": "Batf3", "gene_names_refseq": "9130211I03Rik; Batf3; Snft", "protein_names_uniprotkb": "Basic leucine zipper transcriptional factor ATF-like 3; B-ATF-3", "protein_names_refseq": "B-ATF-3; Jun dimerization protein p21SNFT; basic leucine zipper transcriptional factor ATF-like 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:381319)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19008445;20351058;21867927;21867928;22992524", "class_list": "", "function": "AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens., [UniProtKB, PubMed, PubMed, PubMed]; Study describes a transcription factor, Batf3, that controls development of CD8+ dendritic cells; dendritic cells from Batf3-/- mice were defective in cross-presentation, and Batf3-/- mice lacked virus-specific CD8+ T cell responses to West Nile virus, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009615 response to virus;GO:0043011 myeloid dendritic cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D275-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6W7-1", "uniprot_id": "C16L2_MOUSE", "mass": 18220.0, "length": 172, "protein_name": "CD164 sialomucin-like 2 protein", "gene_name": "Cd164l2", "organism": "Mouse", "refseq_name": "CD164 sialomucin-like 2 protein precursor", "refseq_ac": "NP_081428", "gene_names_uniprotkb": "Cd164l2", "gene_names_refseq": "2310047N01Rik; Cd164l2", "protein_names_uniprotkb": "CD164 sialomucin-like 2 protein", "protein_names_refseq": "CD164 sialomucin-like 2 protein precursor; CD164 sialomucin-like 2 protein; D164 sialomucin-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69655)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34418053", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B1AUM9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D6W7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6W8-1", "uniprot_id": "BORC6_MOUSE", "mass": 38011.0, "length": 360, "protein_name": "BLOC-1-related complex subunit 6", "gene_name": "Borcs6", "organism": "Mouse", "refseq_name": "BLOC-1-related complex subunit 6", "refseq_ac": "NP_082281", "gene_names_uniprotkb": "Borcs6", "gene_names_refseq": "2310047M10Rik; Borcs6", "protein_names_uniprotkb": "BLOC-1-related complex subunit 6", "protein_names_refseq": "BLOC-1-related complex subunit 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:71923)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17242355;19144319;21183079", "class_list": "", "function": "As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TE21", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0098574 cytoplasmic side of lysosomal membrane;GO:0099078 BORC complex", "go_biological_process": "GO:0051036 regulation of endosome size;GO:0032418 lysosome localization;GO:0072384 organelle transport along microtubule;GO:0062196 regulation of lysosome size", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D6W8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAA7-1", "uniprot_id": "SMIP3_MOUSE", "mass": 16975.0, "length": 145, "protein_name": "Protein SPMIP3", "gene_name": "SPMIP3", "organism": "Mouse", "refseq_name": "protein SPMIP3", "refseq_ac": "NP_081353", "gene_names_uniprotkb": "SPMIP3", "gene_names_refseq": "1700016C15Rik; Spmip3", "protein_names_uniprotkb": "Protein SPMIP3; Sperm microtubule inner protein 3; Sperm-associated microtubule inner protein 3", "protein_names_refseq": "protein SPMIP3; sperm associated microtubule inner protein 3; uncharacterized protein C1orf100 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69428)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9DAA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB72-1", "uniprot_id": "BTBDH_MOUSE", "mass": 52602.0, "length": 478, "protein_name": "BTB/POZ domain-containing protein 17", "gene_name": "Btbd17", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein 17 isoform 1 precursor", "refseq_ac": "NP_082331", "gene_names_uniprotkb": "Btbd17", "gene_names_refseq": "1500005I02Rik; Btbd17; Tango10a", "protein_names_uniprotkb": "BTB/POZ domain-containing protein 17; Galectin-3-binding protein-like", "protein_names_refseq": "BTB (POZ) domain containing 17; BTB/POZ domain-containing protein 17 isoform 1 precursor; BTB/POZ domain-containing protein 17", "tax_id": 10090, "disease": "", "pathway": " (mmu:72014)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;30899004;33300544;40885482", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 25, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q9DB72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBI2-1", "uniprot_id": "BBS10_MOUSE", "mass": 78924.0, "length": 713, "protein_name": "BBSome complex assembly protein BBS10", "gene_name": "Bbs10", "organism": "Mouse", "refseq_name": "BBSome complex assembly protein BBS10", "refseq_ac": "NP_082190", "gene_names_uniprotkb": "Bbs10", "gene_names_refseq": "1300007O09Rik; Bbs10", "protein_names_uniprotkb": "BBSome complex assembly protein BBS10; Bardet-Biedl syndrome 10 protein homolog", "protein_names_refseq": "BBSome complex assembly protein BBS10; bardet-Biedl syndrome 10 protein homolog", "tax_id": 10090, "disease": "Bardet-Biedl syndrome 10 (Disease Ontology:DOID:0110132); Bardet-Biedl syndrome (Disease Ontology:DOID:1935)", "pathway": " (mmu:71769); (R-MMU-5620922)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16582908;17106446", "class_list": "", "function": "Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis. Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation., [UniProtKB, UniProtKB]; Report a major new BBS locus, BBS10, that encodes a previously unknown, rapidly evolving vertebrate-specific chaperonin-like protein Erratum:[Nat Genet. 2006 Jun;38(6):727. Da Silva, Eduardo [corrected to Silva, Eduardo D]], [RefSeq, PubMed]; These findings confirm that FLJ23560 (BBS10) mutations are a significant cause of BBS., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005929 cilium", "go_biological_process": "GO:0019228 neuronal action potential;GO:0043524 negative regulation of neuron apoptotic process;GO:0006974 DNA damage response;GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DBI2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QX15-1", "uniprot_id": "CA3A1_MOUSE", "mass": 100108.0, "length": 902, "protein_name": "Calcium-activated chloride channel regulator 3A-1", "gene_name": "Clca3a1", "organism": "Mouse", "refseq_name": "calcium-activated chloride channel regulator 3A-1 precursor", "refseq_ac": "NP_034029", "gene_names_uniprotkb": "Clca3a1; Clca1", "gene_names_refseq": "Cacc; Clca1; Clca3a1", "protein_names_uniprotkb": "Calcium-activated chloride channel regulator 3A-1; 3.4.-.-", "protein_names_refseq": "calcium-activated chloride channel regulator 3A-1 precursor; calcium-activated chloride channel regulator 3A-1; chloride channel calcium activated 1; chloride channel calcium activated 3A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12722)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10072771;25899321;29081444;30899053;34428180;9822685", "class_list": "", "function": "Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner., [UniProtKB, PubMed, PubMed]; Serine 727 phosphorylation in TMEM16A by CaMKIIgamma provides a new mechanism for regulating TMEM16A CaCC activity and Ang II-induced BASMC proliferation., [RefSeq, PubMed]; Together the data suggests that Ca(2+) entry via the TRPC1 channels is essential for the activation of CaCC, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "B7ZN73;O88860;Q3UQR1;Q8C324;Q8CCM1", "ec_number_list": "", "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding;GO:0005229 intracellularly calcium-gated chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9QX15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZA0-1", "uniprot_id": "CAH5B_MOUSE", "mass": 36623.0, "length": 317, "protein_name": "Carbonic anhydrase 5B, mitochondrial", "gene_name": "Ca5b", "organism": "Mouse", "refseq_name": "carbonic anhydrase 5B, mitochondrial precursor", "refseq_ac": "NP_851832", "gene_names_uniprotkb": "Ca5b; Car5b", "gene_names_refseq": "7330410H16Rik; CAVB; Ca5b; Car5b; CarVb; D730005F19Rik", "protein_names_uniprotkb": "Carbonic anhydrase 5B, mitochondrial; 4.2.1.1; CA-VB; Carbonate dehydratase VB; Carbonic anhydrase VB", "protein_names_refseq": "CA-VB; carbonate dehydratase VB; carbonic anhydrase 5B, mitochondrial precursor; carbonic anhydrase VB", "tax_id": 10090, "disease": "", "pathway": " (mmu:56078); (R-MMU-1475029)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10677517;20820888;23589845;36464834", "class_list": "", "function": "Both Car5A and Car5B contribute to both ammonia detoxification (ureagenesis) and regulation of fasting blood sugar (gluconeogenesis)., [RefSeq, PubMed]; Car5b and Car13 showed the highest signals in the mouse harderian gland., [RefSeq, PubMed]; Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease. Review article, [RefSeq, PubMed]; Mitochondrial carbonic anhydrase that catalyzes the reversible conversion of carbon dioxide to bicarbonate/HCO3., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C3J9;Q8K014", "ec_number_list": "4.2.1.1;4.2.1.69", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QZA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0C0-1", "uniprot_id": "BL1S6_MOUSE", "mass": 19682.0, "length": 172, "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 6", "gene_name": "Bloc1s6", "organism": "Mouse", "refseq_name": "biogenesis of lysosome-related organelles complex 1 subunit 6", "refseq_ac": "NP_062762", "gene_names_uniprotkb": "Bloc1s6; P2; Pa; Pldn", "gene_names_refseq": "BLOC-1; Bloc1s6; Hps9; Pldn; Stx13bp1; pa", "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit 6; BLOC-1 subunit 6; Pallid protein; Pallidin; Syntaxin 13-interacting protein", "protein_names_refseq": "BLOC-1 subunit 6; biogenesis of lysosome-related organelles complex 1 subunit 6; biogenesis of organelles complex-1, subunit 6, pallidin; pallid protein; pallidin; syntaxin 13 binding protein 1; syntaxin 13-interacting protein pallid", "tax_id": 10090, "disease": "Hermansky-Pudlak syndrome 9 (Disease Ontology:DOID:0060547); platelet storage pool deficiency (Disease Ontology:DOID:2223); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:18457); (R-MMU-432722)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10610180;11936273;12019270;12191018;12576321;12923531;16760431;17182842;19546860;21998198;30084848;36258293", "class_list": "", "function": "A marked enhancement of a BLOC-1 gene, pallidin, associated with somnolent mouse models deficient in histamine transmission., [RefSeq, PubMed]; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ATW6;Q3TUT4;Q91VG4", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005925 focal adhesion;GO:0016020 membrane;GO:0001725 stress fiber", "go_biological_process": "GO:0003016 respiratory system process;GO:0006536 glutamate metabolic process;GO:0006629 lipid metabolic process;GO:0007613 memory;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9R0C0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R229-1", "uniprot_id": "BMP10_MOUSE", "mass": 47888.0, "length": 421, "protein_name": "Bone morphogenetic protein 10", "gene_name": "Bmp10", "organism": "Mouse", "refseq_name": "bone morphogenetic protein 10 preproprotein", "refseq_ac": "NP_033886", "gene_names_uniprotkb": "Bmp10", "gene_names_refseq": "Bmp10; b2b2711Clo", "protein_names_uniprotkb": "Bone morphogenetic protein 10; BMP-10", "protein_names_refseq": "BMP-10; bone morphogenetic protein 10 preproprotein", "tax_id": 10090, "disease": "hereditary hemorrhagic telangiectasia (Disease Ontology:DOID:1270); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (mmu:12154); (R-MMU-201451); (R-MMU-2129379)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10072785;15073151;15109497;16798733;21737454;37507081", "class_list": "", "function": "Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Results describe an essential role of bone morphogenetic protein 10 in regulating cardiac growth and chamber maturation., [RefSeq, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. Homozygous knockout mice for this gene exhibit impaired heart development and embryonic lethality. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6H6S5;Q9Z1V8", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0031433 telethonin binding;GO:0033612 receptor serine/threonine kinase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0030018 Z disc", "go_biological_process": "GO:0007155 cell adhesion;GO:0007507 heart development;GO:0010628 positive regulation of gene expression;GO:0001822 kidney development;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9R229-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVK5-1", "uniprot_id": "B4GT6_MOUSE", "mass": 44759.0, "length": 382, "protein_name": "Beta-1,4-galactosyltransferase 6", "gene_name": "B4galt6", "organism": "Mouse", "refseq_name": "beta-1,4-galactosyltransferase 6", "refseq_ac": "NP_062711", "gene_names_uniprotkb": "B4galt6", "gene_names_refseq": "B4galt6", "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase 6; 2.4.1.-; 2.4.1.274; Beta-1,4-GalTase 6; Beta4Gal-T6; Glucosylceramide beta-1,4-galactosyltransferase; LacCer synthase; Lactosylceramide synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6; UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6; b4Gal-T6", "protein_names_refseq": "UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6; UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6; b4Gal-T6; beta-1, 4-galactosyltransferase VI; beta-1,4-GalTase 6; beta-1,4-galactosyltransferase 6; beta4Gal-T6; lacCer synthase; lactosylceramide synthase", "tax_id": 10090, "disease": "multiple sclerosis (Disease Ontology:DOID:2377)", "pathway": " (mmu:56386); (R-MMU-2022854); (R-MMU-913709); (R-MMU-975577); (R-MMU-9840309)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;23882130;25216636;30114188;31599954;37828378", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:23882130, PubMed:30114188). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (PubMed:30114188)., [UniProtKB, PubMed, PubMed]; Lactosylceramide (LacCer) synthesized by beta-1,4-galactosyltransferase 6 (B4GALT6) is upregulated in the central nervous system during chronic experimental autoimmune encephalomyelitis, a model of multiple sclerosis., [RefSeq, PubMed]; Lactosylceramide synthase is encoded by B4galt5 and 6 genes in the central nervous system, and these genes are indispensable for neuronal maturation, perineuronal nets formation, and axonal and myelin formation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 12, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-;2.4.1.275;2.4.1.22;2.4.1.38;2.4.1.90;2.4.1.274", "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0046872 metal ion binding;GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0022010 central nervous system myelination;GO:0005975 carbohydrate metabolic process;GO:0030148 sphingolipid biosynthetic process;GO:0021955 central nervous system neuron axonogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9WVK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0F0-1", "uniprot_id": "B3GT4_MOUSE", "mass": 41236.0, "length": 371, "protein_name": "Beta-1,3-galactosyltransferase 4", "gene_name": "B3galt4", "organism": "Mouse", "refseq_name": "beta-1,3-galactosyltransferase 4 precursor", "refseq_ac": "NP_062293", "gene_names_uniprotkb": "B3galt4", "gene_names_refseq": "B3galt4; Gal-T2; Galt2", "protein_names_uniprotkb": "Beta-1,3-galactosyltransferase 4; 2.4.1.62; Beta-1,3-GalTase 4; Beta3Gal-T4; Beta3GalT4; Gal-T2; Ganglioside galactosyltransferase; UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase; b3Gal-T4", "protein_names_refseq": "UDP-Gal:betaGlcNAc beta 13-galactosyltransferase polypeptide 4; UDP-galactose:beta-N-acetyl-galactosamine-beta-1, 3-galactosyltransferase; b3Gal-T4; beta-1,3-GalTase 4; beta-1,3-galactosyltransferase 4 precursor; beta-1,3-galactosyltransferase 4; beta3Gal-T4; beta3GalT4; ganglioside galactosyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:54218); (R-MMU-9037629); (R-MMU-9840309)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10502288;15498585;36284313", "class_list": "glycogene;glycosyltransferase", "function": "Activation of a fragment of 211 bp around the transcription initiation site of the mouse Gal-T2 promoter., [RefSeq, PubMed]; B3GALT4 remodels the tumor microenvironment through GD2-mediated lipid raft formation and the c-met/AKT/mTOR/IRF-1 axis in neuroblastoma. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in GM1/GD1B/GA1 ganglioside biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91VC1;Q920U8;Q920U9", "ec_number_list": "2.4.1.86;2.4.1.-;2.4.1.62", "go_molecular_function": "GO:0016757 glycosyltransferase activity;GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity;GO:0047915 ganglioside galactosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0001574 ganglioside biosynthetic process", "synthesized_glycan_count": 300, "hit_score": 0.4, "record_id": "Q9Z0F0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1S0-1", "uniprot_id": "BUB1B_MOUSE", "mass": 118392.0, "length": 1052, "protein_name": "Mitotic checkpoint serine/threonine-protein kinase BUB1 beta", "gene_name": "Bub1b", "organism": "Mouse", "refseq_name": "mitotic checkpoint serine/threonine-protein kinase BUB1 beta", "refseq_ac": "NP_033903", "gene_names_uniprotkb": "Bub1b; Mad3l", "gene_names_refseq": "BUBR1; Bub1b", "protein_names_uniprotkb": "Mitotic checkpoint serine/threonine-protein kinase BUB1 beta; 2.7.11.1; BubR1; MAD3/BUB1-related protein kinase; Mitotic checkpoint kinase MAD3L", "protein_names_refseq": "MAD3/BUB1-related protein kinase; budding uninhibited by benzimidazoles 1 beta; budding uninhibited by benzimidazoles 1 homolog, beta; mitotic checkpoint kinase MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta", "tax_id": 10090, "disease": "mosaic variegated aneuploidy syndrome 1 (Disease Ontology:DOID:0080141); tongue carcinoma (Disease Ontology:DOID:0080641); pancreatic cancer (Disease Ontology:DOID:1793); gallbladder cancer (Disease Ontology:DOID:3121); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:12236); (R-MMU-141430); (R-MMU-141444); (R-MMU-174184); (R-MMU-176409); (R-MMU-179409); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 11, "publication_count": 17, "publication_id_list": "12925705;14744753;15208629;17925231;20173027;21183079;21952136;25428506;25428507;25605945;30084848;30779550;31219806;34428180;35820727;37782908;9889005", "class_list": "", "function": "Component of the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation until all chromosomes are properly attached to the mitotic spindle (By similarity). The MCC, which consists of CDC20, MAD2L1/MAD2, BUB1B/BUBR1 and BUB3, is a key player of the spindle assembly checkpoint (By similarity). The MCC-bound APC/C complex is inactive and this delays the metaphase/anaphase transition (By similarity). When the spindle assembly checkpoint is silenced, the MCC-APC/C complex recruits the E2 enzyme UBCH10 and triggers the auto-ubiquitination of CDC20 in the MCC, thereby reactivating APC/C for transition into anaphase (By similarity). MCC also monitors kinetochore activities that depend on the kinetochore motor CENPE (By similarity). Required for kinetochore localization of CENPE (By similarity). Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification (By similarity). May play a role for tumor suppression (PubMed:14744753)., [UniProtKB, UniProtKB, PubMed]; Knockdown of BUB1B Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer by Regulating the JNK/c-Jun Signaling Pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ARS1", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;3.4.19.12;2.7.10.2;2.7.11.-;2.7.11.4;3.4.25.1;2.7.11.10;2.7.11.11;3.6.5.-;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.3.2.24;2.3.2.23;2.7.11.21;3.4.22.49;3.6.5.2;3.1.3.16;2.7.11.39;2.3.1.-;2.7.11.31;3.4.21.-;2.3.1.48;4.1.1.32;3.6.4.12;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.3.2.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0071459 protein localization to chromosome, centromeric region;GO:0051301 cell division;GO:0006915 apoptotic process;GO:0051754 meiotic sister chromatid cohesion, centromeric;GO:0007094 mitotic spindle assembly checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9Z1S0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19228-1", "uniprot_id": "CASA1_MOUSE", "mass": 35602.0, "length": 313, "protein_name": "Alpha-S1-casein", "gene_name": "Csn1s1", "organism": "Mouse", "refseq_name": "alpha-S1-casein isoform b precursor", "refseq_ac": "NP_001272944", "gene_names_uniprotkb": "Csn1s1; Csn1; Csna", "gene_names_refseq": "Csn1s1; Csna", "protein_names_uniprotkb": "Alpha-S1-casein; Alpha-casein", "protein_names_refseq": "alpha-S1-casein isoform b precursor; alpha-S1-casein; alpha-casein", "tax_id": 10090, "disease": "", "pathway": " (mmu:12990); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;21789179;2395885;31044023", "class_list": "", "function": "Important role in the capacity of milk to transport calcium phosphate., [UniProtKB, UniProtKB, UniProtKB]; The role of the milk protein alpha-casein by inactivating the corresponding gene in mice, was analysed., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0032570 response to progesterone;GO:0032355 response to estradiol;GO:1903494 response to dehydroepiandrosterone;GO:1903496 response to 11-deoxycorticosterone", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P19228-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61129-1", "uniprot_id": "CFAI_MOUSE", "mass": 67261.0, "length": 603, "protein_name": "Complement factor I", "gene_name": "Cfi", "organism": "Mouse", "refseq_name": "complement factor I isoform 1 preproprotein", "refseq_ac": "NP_031712", "gene_names_uniprotkb": "Cfi; If", "gene_names_refseq": "Cfi", "protein_names_uniprotkb": "Complement factor I; 3.4.21.45; C3B/C4B inactivator", "protein_names_refseq": "C3B/C4B inactivator; complement factor I isoform 1 preproprotein; complement factor I", "tax_id": 10090, "disease": "complement factor I deficiency (Disease Ontology:DOID:0050419); atypical hemolytic-uremic syndrome (Disease Ontology:DOID:0080301); age related macular degeneration 13 (Disease Ontology:DOID:0110025); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); nephrotic syndrome (Disease Ontology:DOID:1184); glomerulonephritis (Disease Ontology:DOID:2921); macular degeneration (Disease Ontology:DOID:4448); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (mmu:12630); (R-MMU-977606)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10204086;16944957;17330941;18202746;21750661;32152506;34428180;39627609;8604219", "class_list": "", "function": "This gene encodes a serine protease that plays an important role in the classical and alternative complement pathways where it cleaves C4b and C3b components of C3 and C5 convertases. The encoded preproprotein undergoes proteolytic processing to generate an active, disulfide-linked heterodimeric enzyme comprised of heavy and light chains. [provided by RefSeq, Jul 2016]., [RefSeq]; Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 8, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "B2RWX8;Q9WU07", "ec_number_list": "3.4.21.45", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:1905370 serine-type endopeptidase complex", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0045087 innate immune response;GO:0006958 complement activation, classical pathway;GO:0006956 complement activation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q61129-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97929-1", "uniprot_id": "BRCA2_MOUSE", "mass": 370664.0, "length": 3329, "protein_name": "Breast cancer type 2 susceptibility protein homolog", "gene_name": "Brca2", "organism": "Mouse", "refseq_name": "breast cancer type 2 susceptibility protein homolog", "refseq_ac": "NP_001074470", "gene_names_uniprotkb": "Brca2; Fancd1", "gene_names_refseq": "Brca2; Fancd1; RAB163", "protein_names_uniprotkb": "Breast cancer type 2 susceptibility protein homolog; Fanconi anemia group D1 protein homolog", "protein_names_refseq": "breast cancer type 2 susceptibility protein homolog; fanconi anemia group D1 protein homolog", "tax_id": 10090, "disease": "medulloblastoma (Disease Ontology:DOID:0050902); ductal carcinoma in situ (Disease Ontology:DOID:0060074); colorectal carcinoma (Disease Ontology:DOID:0080199); Fanconi anemia complementation group D1 (Disease Ontology:DOID:0111089); prostate cancer (Disease Ontology:DOID:10283); atrophy of testis (Disease Ontology:DOID:11994); Fanconi anemia (Disease Ontology:DOID:13636); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); nephroblastoma (Disease Ontology:DOID:2154); ovarian cancer (Disease Ontology:DOID:2394); high grade glioma (Disease Ontology:DOID:3070); osteosarcoma (Disease Ontology:DOID:3347); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); infertility (Disease Ontology:DOID:5223); hereditary breast ovarian cancer syndrome (Disease Ontology:DOID:5683); endometrial serous adenocarcinoma (Disease Ontology:DOID:5750); uveal melanoma (Disease Ontology:DOID:6039); cataract (Disease Ontology:DOID:83); skin melanoma (Disease Ontology:DOID:8923); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:12190); (R-MMU-5685939); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693568); (R-MMU-5693579); (R-MMU-5693616)", "pathway_count": 7, "publication_count": 24, "publication_id_list": "12228710;20062078;21750661;21952136;22872234;25428506;25605945;30084848;30760716;30779550;31219806;31242413;32345962;32460033;34203471;34428180;35820727;37828378;8917547;9063750;9119389;9126738;9196008;9242436", "class_list": "", "function": "Tumor suppressor protein that maintains genome stability primarily by repairing damaged DNA through homologous recombination (HR) (PubMed:9126738). Facilitates the repair of double-strand breaks (DSBs) by binding and mediating the loading of the RAD51 protein onto single-stranded DNA (ssDNA), thereby promoting the activity of RAD51, which catalyzes DNA strand exchange (By similarity). BRCA2 nucleates and stabilizes RAD51 on ssDNA directly and delivers RAD51 to ssDNA-double-stranded DNA (dsDNA) junctions by sliding along dsDNA backbone (By similarity). RAD51 targeting to ssDNA promotes removal of replication protein-A (RPA) from ssDNA and stabilization of RAD51-ssDNA filaments by blocking ATP hydrolysis (By similarity). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (By similarity). Required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability (By similarity). Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (By similarity). Also promotes RAD51 loading to telomeric regions, facilitating telomere replication and capping (By similarity). Also required for homologous recombination during meiosis by promoting the recruitment of RAD51 and DMC1 recombinases to meiotic DSB sites, enabling proper chromosome pairing and crossing over (By similarity). Also promotes homologous recombination by inactivating the FIGNL1-FIRRM complex to protect RAD51 filament from premature disassembly (By similarity). Together with NPM1, may also regulate centrosome duplication (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F8VPU5;O35922;P97383", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0003697 single-stranded DNA binding;GO:0043015 gamma-tubulin binding;GO:0010484 histone H3 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0031619 homologous chromosome orientation in meiotic metaphase I;GO:0006310 DNA recombination;GO:0007283 spermatogenesis;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P97929-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBT3-1", "uniprot_id": "CCD97_MOUSE", "mass": 38724.0, "length": 340, "protein_name": "Coiled-coil domain-containing protein 97", "gene_name": "Ccdc97", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 97 isoform 1", "refseq_ac": "NP_083047", "gene_names_uniprotkb": "Ccdc97; D7Ertd462e", "gene_names_refseq": "1200014H14Rik; 2810446P04Rik; Ccdc97; D7Ertd462e", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 97", "protein_names_refseq": "coiled-coil domain-containing protein 97 isoform 1; coiled-coil domain-containing protein 97", "tax_id": 10090, "disease": "", "pathway": " (mmu:52132)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15345747;21750661;30084848;31219806;34428180", "class_list": "", "function": "May play a role pre-mRNA splicing through the association with the splicing factor SF3B complex which is involved in branch-site recognition., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q922V3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DBT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97817-1", "uniprot_id": "CDR2_MOUSE", "mass": 52090.0, "length": 455, "protein_name": "Cerebellar degeneration-related protein 2", "gene_name": "Cdr2", "organism": "Mouse", "refseq_name": "cerebellar degeneration-related protein 2 isoform 1", "refseq_ac": "NP_031698", "gene_names_uniprotkb": "Cdr2", "gene_names_refseq": "Cdr2", "protein_names_uniprotkb": "Cerebellar degeneration-related protein 2", "protein_names_refseq": "cerebellar degeneration-related protein 2 isoform 1; cerebellar degeneration-related protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:12585)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15345747;21750661;9006982", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UG92", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0001775 cell activation;GO:0002287 alpha-beta T cell activation involved in immune response;GO:0002870 T cell anergy", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97817-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R349-1", "uniprot_id": "CDC16_MOUSE", "mass": 71460.0, "length": 620, "protein_name": "Cell division cycle protein 16 homolog", "gene_name": "Cdc16", "organism": "Mouse", "refseq_name": "cell division cycle protein 16 homolog isoform 1", "refseq_ac": "NP_081552", "gene_names_uniprotkb": "Cdc16; Anapc6", "gene_names_refseq": "2700071J12Rik; 2810431D22Rik; APC6; Cdc16", "protein_names_uniprotkb": "Cell division cycle protein 16 homolog; APC6; Anaphase-promoting complex subunit 6; Cyclosome subunit 6", "protein_names_refseq": "anaphase-promoting complex subunit 6; cell division cycle protein 16 homolog isoform 1; cell division cycle protein 16 homolog; cyclosome subunit 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:69957); (R-MMU-141430); (R-MMU-174048); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-176407); (R-MMU-176408); (R-MMU-176409); (R-MMU-176412); (R-MMU-179409); (R-MMU-2467813); (R-MMU-2559582); (R-MMU-68867); (R-MMU-69017); (R-MMU-983168)", "pathway_count": 17, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;20484733;21183079;21750661;25428506;25605945;30084848;30779550;31219806;34428180;37828378;39627609", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYX9", "ec_number_list": "", "go_molecular_function": "GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005680 anaphase-promoting complex;GO:0072686 mitotic spindle", "go_biological_process": "GO:0051301 cell division;GO:0016567 protein ubiquitination;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0045842 positive regulation of mitotic metaphase/anaphase transition", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8R349-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q6B2-1", "uniprot_id": "CC85C_MOUSE", "mass": 45334.0, "length": 420, "protein_name": "Coiled-coil domain-containing protein 85C", "gene_name": "Ccdc85c", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 85C", "refseq_ac": "NP_001153382", "gene_names_uniprotkb": "Ccdc85c", "gene_names_refseq": "Ccdc85c; EG668158; Gm265; Gm9010; hhy", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 85C", "protein_names_refseq": "coiled-coil domain-containing protein 85C", "tax_id": 10090, "disease": "hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (mmu:668158)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;22056358;31219806", "class_list": "", "function": "May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity). May play an important role in cortical development, especially in the maintenance of radial glia (PubMed:22056358)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005912 adherens junction;GO:0005923 bicellular tight junction;GO:0016607 nuclear speck;GO:0030054 cell junction;GO:0043296 apical junction complex", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0008283 cell population proliferation;GO:0021987 cerebral cortex development;GO:0045184 establishment of protein localization;GO:0030010 establishment of cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9Q6B2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R100-1", "uniprot_id": "CAD17_MOUSE", "mass": 91645.0, "length": 827, "protein_name": "Cadherin-17", "gene_name": "Cdh17", "organism": "Mouse", "refseq_name": "cadherin-17 precursor", "refseq_ac": "NP_062727", "gene_names_uniprotkb": "Cdh17", "gene_names_refseq": "Cdh17; HPT-1/LI; HPT-1", "protein_names_uniprotkb": "Cadherin-17; BILL-cadherin; LI-cadherin; Liver-intestine cadherin; P130", "protein_names_refseq": "BILL-cadherin; LI-cadherin; P130; cadherin-17 precursor; liver-intestine cadherin", "tax_id": 10090, "disease": "", "pathway": " (mmu:12557); (R-MMU-418990)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10906147;11376485;15141301;18250455;21750661;25612318;26495903;26740625;27802388;28011936;28197418;28935714;30047135;30084848;31004701", "class_list": "", "function": "CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways., [RefSeq, PubMed]; Cadherin-17 plays a crucial role in intestinal homeostasis by limiting the permeability of the intestinal epithelium. Cadherin-17 is also a tumour suppressor for intestinal epithelia., [RefSeq, PubMed]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine., [UniProtKB, UniProtKB, UniProtKB]; LI-cadherin originated from an ancestral cadherin with five domains by a partial gene duplication event, [RefSeq, PubMed]; These findings suggest that cadherin-17 plays a crucial role in mediating breast cancer metastasis to bone marrow., [RefSeq, PubMed]; These results suggest that CDH17 plays a role in the long-term survival of MBCs, presumably via an 'MBC niche' comprising, at least in part, BEC in the spleen. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding;GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0002314 germinal center B cell differentiation;GO:0048536 spleen development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9R100-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4V4-1", "uniprot_id": "CBPZ_MOUSE", "mass": 73721.0, "length": 654, "protein_name": "Carboxypeptidase Z", "gene_name": "Cpz", "organism": "Mouse", "refseq_name": "carboxypeptidase Z precursor", "refseq_ac": "NP_694747", "gene_names_uniprotkb": "Cpz", "gene_names_refseq": "Cpz", "protein_names_uniprotkb": "Carboxypeptidase Z; 3.4.17.-; CPZ", "protein_names_refseq": "carboxypeptidase Z precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:242939)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12944424;21750661", "class_list": "", "function": "Specifically cleaves substrates and peptides with C-terminal basic amino acids, especially those containing C-terminal Arg residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "G3X945", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004180 carboxypeptidase activity;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0016485 protein processing;GO:0006518 peptide metabolic process;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R4V4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4H4-1", "uniprot_id": "CBPA5_MOUSE", "mass": 49151.0, "length": 436, "protein_name": "Carboxypeptidase A5", "gene_name": "Cpa5", "organism": "Mouse", "refseq_name": "carboxypeptidase A5 preproprotein", "refseq_ac": "NP_653120", "gene_names_uniprotkb": "Cpa5", "gene_names_refseq": "4930430M09Rik; Cpa5", "protein_names_uniprotkb": "Carboxypeptidase A5; 3.4.17.-", "protein_names_refseq": "carboxypeptidase A5 preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:74649)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11836249;21750661;33745502", "class_list": "", "function": "Predicted gene 31453 (Gm31453) and the gene encoding carboxypeptidase A5 (Cpa5) are not essential for spermatogenesis and male fertility in the mouse., [RefSeq, PubMed]; This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein undergoes proteolytic processing that removes the N-terminal activation peptide to generate a functional enzyme. This gene is expressed in mouse testes where the encoded protein is localized to the germ cells. This gene is located in a cluster of carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R4H4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70269-1", "uniprot_id": "CATE_MOUSE", "mass": 42938.0, "length": 397, "protein_name": "Cathepsin E", "gene_name": "Ctse", "organism": "Mouse", "refseq_name": "cathepsin E preproprotein", "refseq_ac": "NP_031825", "gene_names_uniprotkb": "Ctse", "gene_names_refseq": "A430072O03Rik; C920004C08Rik; CE; CatE; Ctse", "protein_names_uniprotkb": "Cathepsin E; 3.4.23.34", "protein_names_refseq": "cathepsin E preproprotein", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); atopic dermatitis (Disease Ontology:DOID:3310)", "pathway": " (mmu:13034); (R-MMU-2132295)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11322887;11719510;1601038;21750661;26740625;31095099;31343320;32152506;33725478;7983070;9180269;9602058", "class_list": "", "function": "Cathepsin-E deficient animals were highly resistant to (MOG35-55) induced mechanical allodynia., [RefSeq, PubMed]; Infact, decreased CtsE expression levels in BMDM of V30Mmice and their apparent impairment observed to LPSresponse could explain the mechanism for lower immunecell chemotaxis and impaired macrophage function observedin familial amyloid polyneuropathy., [RefSeq, PubMed]; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; This gene encodes a member of the peptidase A1 family of aspartate proteases and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. Homozygous knockout mice for this gene exhibit lysosomal storage disorder, impaired autophagy, mitochondrial abnormalities, dermatitis, and reduced weight gain in an obesity model. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35647;Q3UKT5;Q4FK00", "ec_number_list": "3.4.22.27;3.4.22.15;3.4.22.1;3.4.16.5;3.4.16.-;3.4.23.5;3.4.22.38;3.4.23.34;3.4.14.1;3.4.22.42;3.4.22.41", "go_molecular_function": "GO:0042802 identical protein binding;GO:0008233 peptidase activity;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005768 endosome", "go_biological_process": "GO:0006508 proteolysis;GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0016540 protein autoprocessing", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P70269-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41272-1", "uniprot_id": "CD27_MOUSE", "mass": 28164.0, "length": 250, "protein_name": "CD27 antigen", "gene_name": "Cd27", "organism": "Mouse", "refseq_name": "CD27 antigen isoform a precursor", "refseq_ac": "NP_001028298", "gene_names_uniprotkb": "Cd27; Tnfrsf7", "gene_names_refseq": "Cd27; S152; Tnfrsf7; Tp55", "protein_names_uniprotkb": "CD27 antigen; CD27L receptor; T-cell activation antigen CD27; Tumor necrosis factor receptor superfamily member 7", "protein_names_refseq": "CD antigen 27; CD27 antigen isoform a precursor; CD27L receptor; T-cell activation antigen CD27; tumor necrosis factor receptor superfamily member 7", "tax_id": 10090, "disease": "lymphoproliferative syndrome 2 (Disease Ontology:DOID:0060708); alcohol-associated liver disease (Disease Ontology:DOID:0070658)", "pathway": " (mmu:21940); (R-MMU-5669034)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11062504;15723067;21750661;37024479;38386557;8384562", "class_list": "", "function": "Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells (PubMed:11062504). Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory (By similarity). In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis (PubMed:15723067). Negatively regulates the function of Th2 lymphocytes in the adipose tissue (PubMed:38386557)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Nasopharyngeal carcinoma cells promote regulatory T cell development and suppressive activity via CD70-CD27 interaction. Publication Status: Online-Only, [RefSeq, PubMed]; The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0042110 T cell activation;GO:0032729 positive regulation of type II interferon production;GO:0097191 extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P41272-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29594-1", "uniprot_id": "CASP2_MOUSE", "mass": 50661.0, "length": 452, "protein_name": "Caspase-2", "gene_name": "Casp2", "organism": "Mouse", "refseq_name": "caspase-2 isoform 1 precursor", "refseq_ac": "NP_031636", "gene_names_uniprotkb": "Casp2; Ich1; Nedd-2; Nedd2", "gene_names_refseq": "CASP-2; Casp2; ICH-1; NEDD-2; Nedd2", "protein_names_uniprotkb": "Caspase-2; 3.4.22.55; CASP-2; NEDD-2; Neural precursor cell expressed developmentally down-regulated protein 2; Protease ICH-1", "protein_names_refseq": "caspase-2 isoform 1 precursor; neural precursor cell expressed developmentally down-regulated protein 2; protease ICH-1", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308); Alzheimer's disease (Disease Ontology:DOID:10652); status epilepticus (Disease Ontology:DOID:1824); testicular cancer (Disease Ontology:DOID:2998); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (mmu:12366); (R-MMU-168638); (R-MMU-205025); (R-MMU-6803207)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "1378265;21750661;22872234;31219806;31599954;7958843;9038361", "class_list": "", "function": "Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:7958843). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (By similarity)., [UniProtKB, UniProtKB, PubMed]; This gene encodes the evolutionarily ancient and most conserved member of the cysteine proteases that plays important role in stress-induced apoptosis, DNA repair and tumor suppression. Mice lacking the encoded protein develop normally but display cell type-specific apoptotic defects. Germ cells and oocytes from such mice were found to be resistant to cell death after treatment with chemotherapeutic drugs. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08737;Q3TCM0;Q8C9H7;Q8K241", "ec_number_list": "3.4.22.61;3.4.22.36;3.4.22.55;3.4.22.64;3.4.22.56;3.4.22.62;3.4.21.-", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0008303 caspase complex", "go_biological_process": "GO:0003407 neural retina development;GO:0016485 protein processing;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P29594-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UTZ3-1", "uniprot_id": "TPC14_MOUSE", "mass": 62750.0, "length": 580, "protein_name": "Trafficking protein particle complex subunit 14", "gene_name": "Trappc14", "organism": "Mouse", "refseq_name": "trafficking protein particle complex subunit 14", "refseq_ac": "NP_694801", "gene_names_uniprotkb": "Trappc14; BC037034; Map11", "gene_names_refseq": "Map11; Trappc14", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 14; Microtubule-associated protein 11", "protein_names_refseq": "MAP11 short transcript; microtubule associated protein 11; trafficking protein particle complex subunit 14; uncharacterized protein C7orf43 homolog", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 25 (Disease Ontology:DOID:0051036)", "pathway": " (mmu:231807)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether. TRAPPC14 is dispensable for TRAPPII complex integrity but mediates RAB3IP preciliary vesicle trafficking to the mother centriole during ciliogenesis. Modulates YAP1 activity as transcriptional regulator., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9Q2V5;Q8JZV2", "ec_number_list": "", "go_molecular_function": "GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030496 midbody;GO:0034451 centriolar satellite;GO:0072686 mitotic spindle;GO:1990071 TRAPPII protein complex", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UTZ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20293-1", "uniprot_id": "TBXT_MOUSE", "mass": 47440.0, "length": 436, "protein_name": "T-box transcription factor T", "gene_name": "Tbxt; T", "organism": "Mouse", "refseq_name": "T-box transcription factor T", "refseq_ac": "NP_033335", "gene_names_uniprotkb": "Tbxt; T; T", "gene_names_refseq": "Bra; D17Mit170; Low; Lr; T1; Tbxt; Tl2; Tl3; T; cou; me75", "protein_names_uniprotkb": "T-box transcription factor T; Brachyury protein; Protein T", "protein_names_refseq": "T-box transcription factor T; brachyury protein; brachyury-like 2; brachyury-like 3; low ratio; protein T", "tax_id": 10090, "disease": "neural tube defect (Disease Ontology:DOID:0080074)", "pathway": " (mmu:20997)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "2154694;21750661;7588606;8344258", "class_list": "", "function": "Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation (PubMed:7588606). Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site (PubMed:7588606, PubMed:8344258)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0060379 cardiac muscle cell myoblast differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P20293-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08786-1", "uniprot_id": "CCKAR_MOUSE", "mass": 48437.0, "length": 436, "protein_name": "Cholecystokinin receptor type A", "gene_name": "Cckar", "organism": "Mouse", "refseq_name": "cholecystokinin receptor type A isoform 1", "refseq_ac": "NP_033957", "gene_names_uniprotkb": "Cckar", "gene_names_refseq": "Cckar", "protein_names_uniprotkb": "Cholecystokinin receptor type A; CCK-A receptor; CCK-AR; CCK1-R; Cholecystokinin-1 receptor", "protein_names_refseq": "CCK-A receptor; CCK-AR; CCK1-R; cholecystokinin receptor type A isoform 1; cholecystokinin receptor type A; cholecystokinin-1 receptor", "tax_id": 10090, "disease": "cholelithiasis (Disease Ontology:DOID:10211); pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12425); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "9099891;9245702", "class_list": "", "function": "Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCC7;Q9DBV6", "ec_number_list": "", "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0004951 cholecystokinin receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043195 terminal bouton", "go_biological_process": "GO:0090274 positive regulation of somatostatin secretion;GO:0001659 temperature homeostasis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007409 axonogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O08786-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08918-1", "uniprot_id": "CCNG2_MOUSE", "mass": 38848.0, "length": 344, "protein_name": "Cyclin-G2", "gene_name": "Ccng2", "organism": "Mouse", "refseq_name": "cyclin-G2", "refseq_ac": "NP_031661", "gene_names_uniprotkb": "Ccng2", "gene_names_refseq": "Ccng2", "protein_names_uniprotkb": "Cyclin-G2", "protein_names_refseq": "cyclin-G2", "tax_id": 10090, "disease": "head and neck cancer (Disease Ontology:DOID:11934); rectum cancer (Disease Ontology:DOID:1993); colon cancer (Disease Ontology:DOID:219)", "pathway": " (mmu:12452)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10216255;31978940;33205477;34428180;9139721", "class_list": "", "function": "Cyclin G2 regulates canonical Wnt signalling via interaction with Dapper1 to attenuate tubulointerstitial fibrosis in diabetic nephropathy., [RefSeq, PubMed]; Cyclin G2 upregulation impairs migration, invasion, and network formation through RNF123/Dvl2/JNK signaling in the trophoblast cell line HTR8/SVneo, a possible role in preeclampsia., [RefSeq, PubMed]; May play a role in growth regulation and in negative regulation of cell cycle progression., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35612", "ec_number_list": "", "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O08918-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88430-1", "uniprot_id": "CCL22_MOUSE", "mass": 10302.0, "length": 92, "protein_name": "C-C motif chemokine 22", "gene_name": "Ccl22", "organism": "Mouse", "refseq_name": "C-C motif chemokine 22 precursor", "refseq_ac": "NP_033163", "gene_names_uniprotkb": "Ccl22; Abcd1; Scya22", "gene_names_refseq": "ABCD-1; Ccl22; DCBCK; MDC; Scya22", "protein_names_uniprotkb": "C-C motif chemokine 22; Activated B and dendritic cell-derived; CC chemokine ABCD-1; Small-inducible cytokine A22", "protein_names_refseq": "C-C motif chemokine 22 precursor; C-C motif chemokine 22; CC chemokine ABCD-1; SMALL INDUCIBLE CYTOKINE A22 PRECURSOR (CC CHEMOKINE ABCD-1) (ACTIVATED B AND DENDRITIC CELL-DERIVED); activated B and dendritic cell-derived; chemokine (C-C motif) ligand 22; dendritic cell and B cell derived chemokine; small inducible cytokine subfamily A, member 22; small inducible cytokine subfamily A22; small-inducible cytokine A22", "tax_id": 10090, "disease": "pleural tuberculosis (Disease Ontology:DOID:106); lung cancer (Disease Ontology:DOID:1324); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); pulmonary fibrosis (Disease Ontology:DOID:3770); rhinitis (Disease Ontology:DOID:4483); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:20299); (R-MMU-380108)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "35513723;37353188;38924414;9687523", "class_list": "", "function": "Activation of G-protein-coupled receptor 183 initiates inflammatory pain via macrophage CCL22 secretion., [RefSeq, PubMed]; CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk., [RefSeq, PubMed]; Chemotactic for activated T-lymphocytes. May play an important role in the collaboration of dendritic cells and B-lymphocytes with T-cells in immune responses., [UniProtKB]; Macrophage-derived chemokine CCL22 establishes local LN-mediated adaptive thermogenesis and energy expenditure., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88430-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03953-1", "uniprot_id": "CFAD_MOUSE", "mass": 28057.0, "length": 259, "protein_name": "Complement factor D", "gene_name": "Cfd", "organism": "Mouse", "refseq_name": "complement factor D isoform 2 preproprotein", "refseq_ac": "NP_001278844", "gene_names_uniprotkb": "Cfd; Adn; Df", "gene_names_refseq": "Adn; Cfd; DF", "protein_names_uniprotkb": "Complement factor D; 28 kDa adipocyte protein; 3.4.21.46; Adipsin; C3 convertase activator; Properdin factor D", "protein_names_refseq": "28 kDa adipocyte protein; C3 convertase activator; D component (adipsin) of complement; complement factor D (adipsin); complement factor D isoform 2 preproprotein; properdin factor D", "tax_id": 10090, "disease": "arthus reaction (Disease Ontology:DOID:1556); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11537); (R-MMU-114608); (R-MMU-173736); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "16944957;17330941;30084848;3015943;3024123;30779550;34428180;38072993;38713526;3901003", "class_list": "", "function": "Adipsin and adipocyte-derived C3aR1 regulate thermogenic fat in a sex-dependent fashion. Publication Status: Online-Only, [RefSeq, PubMed]; Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid beta-oxidation to alleviate diabetic cardiomyopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Serine protease that initiates the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. In contrast to other complement pathways (classical, lectin and GZMK) that are directly activated by pathogens or antigen-antibody complexes, the alternative complement pathway is initiated by the spontaneous hydrolysis of complement C3. The alternative complement pathway acts as an amplification loop that enhances complement activation by mediating the formation of C3 and C5 convertases. Activated CFD cleaves factor B (CFB) when the latter is complexed with complement C3b, activating the C3 convertase of the alternative pathway., [UniProtKB, UniProtKB]; This gene encodes a serine protease that plays an important role in the alternative pathway of complement activation for pathogen recognition and elimination. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme that in turn cleaves factor B in the complement pathway. This gene is expressed in adipocytes and the mature enzyme is secreted into the bloodstream. Mice lacking the encoded product cannot initiate alternative pathway of complement activation. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q61280", "ec_number_list": "2.4.1.25;3.2.1.33;3.5.4.6;1.11.1.24;3.4.22.52;3.4.19.12;3.4.22.27;1.1.1.42;3.4.21.46;3.4.21.47;4.1.2.13;5.3.1.9;5.1.3.-;3.6.4.10;2.4.2.7;1.16.3.1;3.6.5.-;4.2.1.24;3.4.22.1;3.2.1.31;2.7.1.11;2.7.10.2;5.2.1.8;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;5.3.2.1;5.3.3.12;3.4.24.35;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;1.11.1.7;3.1.6.12;2.7.11.1;2.7.1.40;3.5.4.5;3.4.25.1;2.7.11.39;2.7.4.6;2.7.13.3;3.6.4.6;2.7.1.1;2.7.1.-;3.1.1.47;3.6.4.13;2.7.11.22;2.7.11.23;2.3.2.26;5.4.2.2;5.4.2.7;2.3.2.27;3.1.6.14;2.3.2.13;1.8.3.2;1.8.3.5;2.7.1.35;1.-.-.-;3.4.19.1;3.6.1.6;2.3.3.8;4.1.2.4;2.3.2.5;5.4.2.11;5.4.2.4;2.4.1.1;2.4.1.186;3.4.18.1;3.5.1.23;3.5.1.-", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0035886 vascular associated smooth muscle cell differentiation;GO:0007219 Notch signaling pathway;GO:0009617 response to bacterium;GO:0060041 retina development in camera-type eye;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P03953-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09240-1", "uniprot_id": "CCKN_MOUSE", "mass": 12770.0, "length": 115, "protein_name": "Cholecystokinin", "gene_name": "Cck", "organism": "Mouse", "refseq_name": "cholecystokinin isoform 2 precursor", "refseq_ac": "NP_001271437", "gene_names_uniprotkb": "Cck", "gene_names_refseq": "Cck", "protein_names_uniprotkb": "Cholecystokinin; CCK", "protein_names_refseq": "cholecystokinin isoform 2 precursor", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); morbid obesity (Disease Ontology:DOID:11981); acute pancreatitis (Disease Ontology:DOID:2913); alcoholic pancreatitis (Disease Ontology:DOID:4988); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:12424); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "2011497;21750661;22872234;23863714;30084848;3862083", "class_list": "", "function": "This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Homozygous knockout mice for this gene exhibit impaired insulin secretion, enhanced insulin sensitivity, and resistance to obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]., [RefSeq]; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53WS9;Q9DCL5", "ec_number_list": "", "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:1903999 negative regulation of eating behavior;GO:0007409 axonogenesis;GO:0007613 memory;GO:0008284 positive regulation of cell population proliferation;GO:0008542 visual learning", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P09240-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10146-1", "uniprot_id": "CCL1_MOUSE", "mass": 10276.0, "length": 92, "protein_name": "C-C motif chemokine 1", "gene_name": "Ccl1", "organism": "Mouse", "refseq_name": "C-C motif chemokine 1 precursor", "refseq_ac": "NP_035459", "gene_names_uniprotkb": "Ccl1; Scya1; Tca3", "gene_names_refseq": "Ccl1; I-309; P500; Scya1; Tca-3; Tca3", "protein_names_uniprotkb": "C-C motif chemokine 1; P500; SIS-epsilon; Small-inducible cytokine A1; T-cell activation protein 3; TCA-3; TCA3", "protein_names_refseq": "C-C motif chemokine 1 precursor; C-C motif chemokine 1; CCR8 ligand; SIS-epsilon; T-cell activation protein 3; chemokine (C-C motif) ligand 1; small-inducible cytokine A1", "tax_id": 10090, "disease": "multiple sclerosis (Disease Ontology:DOID:2377); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); pulmonary tuberculosis (Disease Ontology:DOID:2957); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); tuberculosis (Disease Ontology:DOID:399); rhinitis (Disease Ontology:DOID:4483)", "pathway": " (mmu:20290); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10438970;21750661;2521353;31121182;33613532;3499466;37220693", "class_list": "", "function": "CCR8 Signaling via CCL1 Regulates Responses of Intestinal IFN-gamma Producing Innate Lymphoid CelIs and Protects From Experimental Colitis. Publication Status: Online-Only, [RefSeq, PubMed]; Cytokine that is chemotactic for neutrophils., [UniProtKB]; Disruption of the CCL1-CCR8 axis promotes atherosclerosis., [RefSeq, PubMed]; The chemokine CCL1 facilitates pulmonary fibrosis by promoting macrophage migration and M2 polarization., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P14098;Q9QUR9;Q9QUS5", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0032740 positive regulation of interleukin-17 production;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P10146-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10148-1", "uniprot_id": "CCL2_MOUSE", "mass": 16326.0, "length": 148, "protein_name": "C-C motif chemokine 2", "gene_name": "Ccl2", "organism": "Mouse", "refseq_name": "C-C motif chemokine 2 precursor", "refseq_ac": "NP_035463", "gene_names_uniprotkb": "Ccl2; Je; Mcp1; Scya2", "gene_names_refseq": "Ccl2; HC11; JE; MCAF; MCP-1; MCP1; SMC-CF; Scya2; Sigje", "protein_names_uniprotkb": "C-C motif chemokine 2; MCP-1; Monocyte chemoattractant protein 1; Monocyte chemotactic protein 1; Platelet-derived growth factor-inducible protein JE; Small-inducible cytokine A2", "protein_names_refseq": "C-C motif chemokine 2 precursor; C-C motif chemokine 2; chemokine (C-C motif) ligand 2; monocyte chemoattractant protein 1; monocyte chemotactic protein 1; platelet-derived growth factor-inducible protein JE; small-inducible cytokine A2", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); obstructive sleep apnea (Disease Ontology:DOID:0050848); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); lupus nephritis (Disease Ontology:DOID:0080162); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); COVID-19 (Disease Ontology:DOID:0080600); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Graves ophthalmopathy (Disease Ontology:DOID:0081120); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); age related macular degeneration (Disease Ontology:DOID:10871); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); intracranial aneurysm (Disease Ontology:DOID:10941); nephritis (Disease Ontology:DOID:10952); IgA vasculitis (Disease Ontology:DOID:11123); sarcoma (Disease Ontology:DOID:1115); pneumocystosis (Disease Ontology:DOID:11339); pulmonary edema (Disease Ontology:DOID:11396); sciatic neuropathy (Disease Ontology:DOID:11446); familial hyperlipidemia (Disease Ontology:DOID:1168); diabetic angiopathy (Disease Ontology:DOID:11713); gestational diabetes (Disease Ontology:DOID:11714); Chagas disease (Disease Ontology:DOID:12140); alcoholic hepatitis (Disease Ontology:DOID:12351); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); Guillain-Barre syndrome (Disease Ontology:DOID:12842); autistic disorder (Disease Ontology:DOID:12849); cardiovascular system disease (Disease Ontology:DOID:1287); endomyocardial fibrosis (Disease Ontology:DOID:12932); intracranial vasospasm (Disease Ontology:DOID:13100); crescentic glomerulonephritis (Disease Ontology:DOID:13139); uveitis (Disease Ontology:DOID:13141); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); hepatic encephalopathy (Disease Ontology:DOID:13413); obstructive jaundice (Disease Ontology:DOID:13603); anterior uveitis (Disease Ontology:DOID:1407); toxic shock syndrome (Disease Ontology:DOID:14115); aggressive periodontitis (Disease Ontology:DOID:1474); cystic fibrosis (Disease Ontology:DOID:1485); fungal infectious disease (Disease Ontology:DOID:1564); thrombocytopenia (Disease Ontology:DOID:1588); status epilepticus (Disease Ontology:DOID:1824); hyperinsulinism (Disease Ontology:DOID:2018); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); orchitis (Disease Ontology:DOID:2518); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); ischemia (Disease Ontology:DOID:326); bipolar disorder (Disease Ontology:DOID:3312); coronary artery disease (Disease Ontology:DOID:3393); pulmonary fibrosis (Disease Ontology:DOID:3770); gastritis (Disease Ontology:DOID:4029); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); macular retinal edema (Disease Ontology:DOID:4449); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); retinal detachment (Disease Ontology:DOID:5327); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); fibromyalgia (Disease Ontology:DOID:631); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); lipodystrophy (Disease Ontology:DOID:811); myocarditis (Disease Ontology:DOID:820); periapical periodontitis (Disease Ontology:DOID:823); periodontitis (Disease Ontology:DOID:824); lung disease (Disease Ontology:DOID:850); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352); cholangitis (Disease Ontology:DOID:9446); pulmonary embolism (Disease Ontology:DOID:9477); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20296)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10438970;2065676;23233732;28011936;2910858;29993042;3287374", "class_list": "", "function": "Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (PubMed:29993042). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (PubMed:29993042)., [UniProtKB, UniProtKB, PubMed]; This gene is one of several cytokine genes clustered on chromosome 11. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and memory T cells but not for neutrophils. The human ortholog has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis, and atherosclerosis. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 100, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYD7", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0001664 G protein-coupled receptor binding;GO:0005125 cytokine activity;GO:0008009 chemokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043204 perikaryon", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0001525 angiogenesis;GO:0006954 inflammatory response;GO:0010332 response to gamma radiation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P10148-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10855-1", "uniprot_id": "CCL3_MOUSE", "mass": 10345.0, "length": 92, "protein_name": "C-C motif chemokine 3", "gene_name": "Ccl3", "organism": "Mouse", "refseq_name": "C-C motif chemokine 3 precursor", "refseq_ac": "NP_035467", "gene_names_uniprotkb": "Ccl3; Mip1a; Scya3", "gene_names_refseq": "Ccl3; G0S19-1; LD78alpha; MIP-1alpha; MIP1-(a); MIP1-alpha; Mip1a; Scya3", "protein_names_uniprotkb": "C-C motif chemokine 3; Heparin-binding chemotaxis protein; L2G25B; MIP-1-alpha; Macrophage inflammatory protein 1-alpha; SIS-alpha; Small-inducible cytokine A3; TY-5", "protein_names_refseq": "C-C motif chemokine 3 precursor; C-C motif chemokine 3; L2G25B; MIP-1-alpha; MIP1 (a); SIS-alpha; TY-5; chemokine (C-C motif) ligand 3; heparin-binding chemotaxis protein; macrophage inflammatory protein 1-alpha; macrophage inflammatory protein-1alpha; small-inducible cytokine A3", "tax_id": 10090, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); COVID-19 (Disease Ontology:DOID:0080600); nephritis (Disease Ontology:DOID:10952); Chagas disease (Disease Ontology:DOID:12140); alcoholic hepatitis (Disease Ontology:DOID:12351); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); crescentic glomerulonephritis (Disease Ontology:DOID:13139); anterior uveitis (Disease Ontology:DOID:1407); status epilepticus (Disease Ontology:DOID:1824); colon cancer (Disease Ontology:DOID:219); acute kidney failure (Disease Ontology:DOID:3021); systemic scleroderma (Disease Ontology:DOID:418); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:20302); (R-MMU-380108)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10438970;2033269;2216738;2521353;2784565;3279154;3290382;33630763", "class_list": "", "function": "Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P14096", "ec_number_list": "", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0016301 kinase activity;GO:0016004 phospholipase activator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007267 cell-cell signaling;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P10855-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30882-1", "uniprot_id": "CCL5_MOUSE", "mass": 10071.0, "length": 91, "protein_name": "C-C motif chemokine 5", "gene_name": "Ccl5", "organism": "Mouse", "refseq_name": "C-C motif chemokine 5 precursor", "refseq_ac": "NP_038681", "gene_names_uniprotkb": "Ccl5; Scya5", "gene_names_refseq": "Ccl5; MuRantes; RANTES; SISd; Scya5; TCP228", "protein_names_uniprotkb": "C-C motif chemokine 5; MuRantes; SIS-delta; Small-inducible cytokine A5; T-cell-specific protein RANTES", "protein_names_refseq": "C-C motif chemokine 5 precursor; C-C motif chemokine 5; SIS-delta; T-cell-specific protein RANTES; chemokine (C-C motif) ligand 5; small-inducible cytokine A5", "tax_id": 10090, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); cardiac arrest (Disease Ontology:DOID:0060319); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); COVID-19 (Disease Ontology:DOID:0080600); exercise-induced bronchoconstriction (Disease Ontology:DOID:0080821); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); glucose intolerance (Disease Ontology:DOID:10603); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); allergic conjunctivitis (Disease Ontology:DOID:11204); sciatic neuropathy (Disease Ontology:DOID:11446); Chagas disease (Disease Ontology:DOID:12140); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); bronchopneumonia (Disease Ontology:DOID:12375); posterior uveitis (Disease Ontology:DOID:12574); uveitis (Disease Ontology:DOID:13141); pulmonary sarcoidosis (Disease Ontology:DOID:13406); peptic esophagitis (Disease Ontology:DOID:13976); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); orchitis (Disease Ontology:DOID:2518); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); antiphospholipid syndrome (Disease Ontology:DOID:2988); invasive ductal carcinoma (Disease Ontology:DOID:3008); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); cocaine abuse (Disease Ontology:DOID:809); extrinsic allergic alveolitis (Disease Ontology:DOID:841); lung disease (Disease Ontology:DOID:850); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20304); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10438970;1375672;1376260;28011936;38497114;7507961;7513046", "class_list": "", "function": "Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells., [UniProtKB, UniProtKB]; The myokine CCL5 recruits subcutaneous preadipocytes and promotes intramuscular fat deposition in obese mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 54, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0004672 protein kinase activity;GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007267 cell-cell signaling;GO:0010628 positive regulation of gene expression;GO:0010820 positive regulation of T cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P30882-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51670-1", "uniprot_id": "CCL9_MOUSE", "mass": 13871.0, "length": 122, "protein_name": "C-C motif chemokine 9", "gene_name": "Ccl9", "organism": "Mouse", "refseq_name": "C-C motif chemokine 9 precursor", "refseq_ac": "NP_035468", "gene_names_uniprotkb": "Ccl9; Mrp2; Scya10; Scya9", "gene_names_refseq": "CCF18; Ccl9; MRP-2; Scya10; Scya9", "protein_names_uniprotkb": "C-C motif chemokine 9; CCF18; MIP-1-gamma; MRP-2; Macrophage inflammatory protein 1-gamma; Macrophage inflammatory protein-related protein 2; Small-inducible cytokine A9", "protein_names_refseq": "C-C motif chemokine 9 precursor; C-C motif chemokine 9; MIP-1 gamma; chemokine (C-C motif) ligand 9; macrophage inflammatory protein 1-gamma; macrophage inflammatory protein-related protein 2; small inducible cytokine A10; small inducible cytokine A9", "tax_id": 10090, "disease": "", "pathway": " (mmu:20308); (R-MMU-416476); (R-MMU-418594); (R-MMU-444473)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10438970;15905581;26495903;29891873;30365155;32152506;7594550;7650394;8597875", "class_list": "", "function": "CCL9 secreted by splenic macrophages induces a CCR1dependent accumulation of MDSCs., [RefSeq, PubMed]; In conclusion, Cxcl16 expressed in pancreatic acini contributes to the development of acinar cell necrosis through the induction of Ccl9 and subsequent neutrophil infiltration. Publication Status: Online-Only, [RefSeq, PubMed]; Monokine with inflammatory, pyrogenic and chemokinetic properties. Circulates at high concentrations in the blood of healthy animals. Binding to a high-affinity receptor activates calcium release in neutrophils. It also inhibits colony formation of bone marrow myeloid immature progenitors., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5QNW2", "ec_number_list": "", "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031726 CCR1 chemokine receptor binding;GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P51670-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51944-1", "uniprot_id": "CCNF_MOUSE", "mass": 86623.0, "length": 777, "protein_name": "Cyclin-F", "gene_name": "Ccnf", "organism": "Mouse", "refseq_name": "cyclin-F isoform 4", "refseq_ac": "NP_031660", "gene_names_uniprotkb": "Ccnf", "gene_names_refseq": "Ccnf; CycF; Fbxo1", "protein_names_uniprotkb": "Cyclin-F", "protein_names_refseq": "G2/mitotic-specific cyclin-F; cyclin-F isoform 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:12449); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "11572993;12867420;14993286;18299400;21750661;21952136;25428506;25605945;30084848;30779550;34428180;35820727;38916959;7767003", "class_list": "", "function": "CycF(-/-) animals, with a myriad of developmental anomalies due in large part to failures in yolk sac and chorioallantoic placentation, die around embryonic day 10.5., [RefSeq, PubMed]; Injury-induced Foxm1 expression in the mouse kidney drives epithelial proliferation by a cyclin F-dependent mechanism. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (By similarity). Mediates the substrate recognition and the proteasomal degradation of various target proteins involved in the regulation of cell cycle progression and in the maintenance of genome stability (By similarity). Mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication (By similarity). In G2, mediates the ubiquitination and proteasomal degradation of CDC6, thereby suppressing DNA re-replication and preventing genome instability (By similarity). Involved in the ubiquitination and degradation of the substrate adapter CDH1 of the anaphase-promoting complex (APC/C), thereby acting as an antagonist of APC/C in regulating G1 progression and S phase entry (By similarity). May play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TF73;Q60797;Q60799;Q8BSX9;Q8C4D9;Q8CI26", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0010997 anaphase-promoting complex binding;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0051301 cell division;GO:0001890 placenta development;GO:0016567 protein ubiquitination;GO:0000082 G1/S transition of mitotic cell cycle;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P51944-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61215-1", "uniprot_id": "CAH10_MOUSE", "mass": 37563.0, "length": 328, "protein_name": "Carbonic anhydrase-related protein 10", "gene_name": "Ca10; Car10", "organism": "Mouse", "refseq_name": "carbonic anhydrase-related protein 10 precursor", "refseq_ac": "NP_082572", "gene_names_uniprotkb": "Ca10; Car10; Car10", "gene_names_refseq": "2700029L05Rik; Ca10; Car10", "protein_names_uniprotkb": "Carbonic anhydrase-related protein 10; CA-RP X; CARP X; Carbonic anhydrase-related protein X", "protein_names_refseq": "CA-RP X; CARP X; carbonic anhydrase-related protein 10 precursor; carbonic anhydrase-related protein 10; carbonic anhydrase-related protein X", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:72605)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12531530;21750661;28154140;30899004;33300544", "class_list": "", "function": "CA10 directly binds in a cis configuration to a conserved membrane-proximal, extracellular sequence of alpha- and beta-neurexins. Erratum:[Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2984. doi: 10.1073/pnas.1703198114. PMID: 28320946], [RefSeq, PubMed]; Does not have a catalytic activity., [UniProtKB, UniProtKB, UniProtKB]; Results describe the tissue distribution of carbonic anhydrase-related proteins VIII, X, and XI and their developmental expression in the murine embryonic brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016836 hydro-lyase activity;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P61215-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P79621-1", "uniprot_id": "C2TA_MOUSE", "mass": 127528.0, "length": 1155, "protein_name": "MHC class II transactivator", "gene_name": "Ciita", "organism": "Mouse", "refseq_name": "MHC class II transactivator isoform 3", "refseq_ac": "NP_001230690", "gene_names_uniprotkb": "Ciita; C2ta; Mhc2ta", "gene_names_refseq": "C2ta; Ciita; EG669998; Gm9475; Mhc2ta", "protein_names_uniprotkb": "MHC class II transactivator; 2.3.1.-; 2.7.11.1; CIITA", "protein_names_refseq": "MHC class II transactivator isoform 3; MHC class II transactivator", "tax_id": 10090, "disease": "osteoporosis (Disease Ontology:DOID:11476); Addison's disease (Disease Ontology:DOID:13774); multiple sclerosis (Disease Ontology:DOID:2377); MHC class II deficiency (Disease Ontology:DOID:5812); myocardial infarction (Disease Ontology:DOID:5844); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); rheumatoid arthritis (Disease Ontology:DOID:7148); periapical periodontitis (Disease Ontology:DOID:823); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12265)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "21750661;25428506;32855215;34428180;35820727;36223747;37108368;37327784;8620527;8995190;9184229", "class_list": "", "function": "Cancer-specific T helper shared and neo-epitopes uncovered by expression of the MHC class II master regulator CIITA. Erratum:[Cell Rep. 2022 Nov 22;41(8):111680. doi: 10.1016/j.celrep.2022.111680. PMID: 36417866], [RefSeq, PubMed]; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter (PubMed:37327784). Does not bind DNA (By similarity). May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both (By similarity). Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (By similarity). Also mediates enhanced MHC class I transcription, the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes (By similarity). Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity (By similarity). Exhibits serine/threonine protein kinase activity: phosphorylates the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the NOD-like receptor protein family. This protein acts as a transcriptional coactivator and component of the enhanceosome complex to stimulate transcription of MHC class II genes in the adaptive immune response. This protein may also regulate the transcription of MHC class I genes. Mutations in the human gene have been linked to a rare immunodeficiency, bare lymphocyte syndrome, and homozygous knockout mice exhibit many features of this disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O46787;O78036;O78109;Q31115;Q9TPP1", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0009986 cell surface;GO:0016605 PML body", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P79621-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84444-1", "uniprot_id": "CC21A_MOUSE", "mass": 14558.0, "length": 133, "protein_name": "C-C motif chemokine 21a", "gene_name": "Ccl21a", "organism": "Mouse", "refseq_name": "C-C motif chemokine 21a precursor", "refseq_ac": "NP_035254", "gene_names_uniprotkb": "Ccl21a; Scya21a; Scya21", "gene_names_refseq": "6CKBAC2; 6Ckine; ALP; CKb9; Ccl21a; Gm1987; SCYA21a; SLC; Scya21b; Scya21; Tca4; plt", "protein_names_uniprotkb": "C-C motif chemokine 21a; 6Ckine; Beta-chemokine exodus-2; Small-inducible cytokine A21a; TCA4; Thymus-derived chemotactic agent 4", "protein_names_refseq": "C-C motif chemokine 21a precursor; C-C motif chemokine 21a; CC chemokine 6Ckine-ser; CCL21-Ser; beta-chemokine exodus-2; chemokine (C-C motif) ligand 21A (serine); exodus-2; small inducible cytokine A21a; thymus-derived chemotactic agent 4", "tax_id": 10090, "disease": "pulmonary fibrosis (Disease Ontology:DOID:3770)", "pathway": " (mmu:18829); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10523616;11123313;31875850;37421165;9257816;9419363;9548511", "class_list": "", "function": "Binds to chemokine receptors CCR7 and CXCR3. Also binds to G protein-coupled receptor GPR174 (PubMed:31875850). Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs., [UniProtKB, PubMed]; CCL21-Ser expression in melanoma cells recruits CCR7[+] naive T cells to tumor tissues and promotes tumor growth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09002;O09006;Q3U1J2;Q91V84", "ec_number_list": "", "go_molecular_function": "GO:0008009 chemokine activity;GO:0042379 chemokine receptor binding;GO:0048020 CCR chemokine receptor binding;GO:0031732 CCR7 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1990869 cellular response to chemokine;GO:2000669 negative regulation of dendritic cell apoptotic process;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0010820 positive regulation of T cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P84444-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P86792-1", "uniprot_id": "CC21B_MOUSE", "mass": 14584.0, "length": 133, "protein_name": "C-C motif chemokine 21b", "gene_name": "Ccl21b", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ccl21b; Scya21b; Scya21", "gene_names_refseq": "", "protein_names_uniprotkb": "C-C motif chemokine 21b; 6Ckine; Beta-chemokine exodus-2; Small-inducible cytokine A21b; TCA4; Thymus-derived chemotactic agent 4", "protein_names_refseq": "", "tax_id": 10090, "disease": "pulmonary fibrosis (Disease Ontology:DOID:3770)", "pathway": " (mmu:100042493); (mmu:100504239); (mmu:100504346); (mmu:100862177); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "10523616;11123313;26495903;9300671;9419363", "class_list": "", "function": "Binds to chemokine receptors CCR7 and CXCR3. Also binds to G protein-coupled receptor GPR174 (By similarity). Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09002;O09006;P84443;Q5M8M5;Q91V84", "ec_number_list": "", "go_molecular_function": "GO:0008009 chemokine activity;GO:0042379 chemokine receptor binding;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:2000669 negative regulation of dendritic cell apoptotic process;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0030335 positive regulation of cell migration;GO:0046330 positive regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P86792-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P86793-1", "uniprot_id": "CC21C_MOUSE", "mass": 14584.0, "length": 133, "protein_name": "C-C motif chemokine 21c", "gene_name": "Ccl21c", "organism": "Mouse", "refseq_name": "C-C motif chemokine 21b precursor", "refseq_ac": "NP_001180595", "gene_names_uniprotkb": "Ccl21c; Scya21c", "gene_names_refseq": "6Ckine; Ccl21b; Ccl21c; Ccl21f; Gm13304; Scya21b; Scya21c; Scya21; TCA4", "protein_names_uniprotkb": "C-C motif chemokine 21c; 6Ckine; Beta-chemokine exodus-2; Small-inducible cytokine A21c; TCA4; Thymus-derived chemotactic agent 4", "protein_names_refseq": "Beta-chemokine exodus-2; C-C motif chemokine 21b precursor; C-C motif chemokine 21b; C-C motif chemokine 21c; Small-inducible cytokine A21b; Small-inducible cytokine A21c; Thymus-derived chemotactic agent 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:100042493); (mmu:100504239); (mmu:100504346); (mmu:100862177)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11123313;9419363", "class_list": "", "function": "Binds to chemokine receptors CCR7 and CXCR3. Also binds to G protein-coupled receptor GPR174 (By similarity). Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09002;O09006;P84443;Q5M8M5;Q91V84", "ec_number_list": "", "go_molecular_function": "GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway;GO:0048245 eosinophil chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P86793-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00493-1", "uniprot_id": "CBPE_MOUSE", "mass": 53256.0, "length": 476, "protein_name": "Carboxypeptidase E", "gene_name": "Cpe", "organism": "Mouse", "refseq_name": "carboxypeptidase E preproprotein", "refseq_ac": "NP_038522", "gene_names_uniprotkb": "Cpe", "gene_names_refseq": "CPH; Cpe; Cph-1; Cph1; NF-alpha1; fat", "protein_names_uniprotkb": "Carboxypeptidase E; 3.4.17.10; CPE; CPH; Carboxypeptidase H; Enkephalin convertase; Prohormone-processing carboxypeptidase", "protein_names_refseq": "carboxypeptidase E preproprotein; carboxypeptidase H; enkephalin convertase; prohormone-processing carboxypeptidase", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); morbid obesity (Disease Ontology:DOID:11981); atherosclerosis (Disease Ontology:DOID:1936); glioblastoma (Disease Ontology:DOID:3068); coronary artery disease (Disease Ontology:DOID:3393); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12876)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10896946;16219686;18322192;20485683;30899004;37364047;37967211;40885482;7663508", "class_list": "", "function": "Deletion of Carboxypeptidase E in beta-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice., [RefSeq, PubMed]; Sorting receptor that directs prohormones to the regulated secretory pathway. Also acts as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage., [UniProtKB, PubMed, PubMed]; This gene encodes carboxypeptidase E, a prohormone-processing exopeptidase found in secretory granules of endocrine and neuroendocrine cells. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme that cleaves the C-terminal basic residues of protein substrates. A missense mutation in this gene is responsible for the obesity phenotype in a mouse model known as the 'fat mouse.' Mice lacking the functional product of this gene exhibit impaired processing of multiple peptide hormones such as proinsulin, prodynorphin, proneurotensin, promelanin-concentrating hormone and pro-opiomelanocortin. [provided by RefSeq, Jan 2016]., [RefSeq]; Top-Down Proteomics of Mouse Islets With Beta Cell CPE Deletion Reveals Molecular Details in Prohormone Processing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q64439", "ec_number_list": "3.4.21.94;3.4.21.93;3.4.17.10", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0004180 carboxypeptidase activity;GO:0050839 cell adhesion molecule binding;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0030141 secretory granule", "go_biological_process": "GO:0016485 protein processing;GO:0001764 neuron migration;GO:0043171 peptide catabolic process;GO:0070301 cellular response to hydrogen peroxide;GO:0071549 cellular response to dexamethasone stimulus", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q00493-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24JP4-1", "uniprot_id": "CE047_MOUSE", "mass": 18286.0, "length": 165, "protein_name": "Uncharacterized protein C5orf47 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C5orf47 homolog", "refseq_ac": "NP_080538", "gene_names_uniprotkb": "", "gene_names_refseq": "4930524B15Rik", "protein_names_uniprotkb": "Uncharacterized protein C5orf47 homolog", "protein_names_refseq": "uncharacterized protein C5orf47 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67592)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CER9;Q9CQS0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q24JP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3MI99-1", "uniprot_id": "CCBE1_MOUSE", "mass": 44357.0, "length": 408, "protein_name": "Collagen and calcium-binding EGF domain-containing protein 1", "gene_name": "Ccbe1", "organism": "Mouse", "refseq_name": "collagen and calcium-binding EGF domain-containing protein 1 precursor", "refseq_ac": "NP_848908", "gene_names_uniprotkb": "Ccbe1; Kiaa1983", "gene_names_refseq": "4933426F18Rik; 9430093N24Rik; Ccbe1; mKIAA1983", "protein_names_uniprotkb": "Collagen and calcium-binding EGF domain-containing protein 1; Full of fluid protein homolog", "protein_names_refseq": "collagen and calcium-binding EGF domain-containing protein 1 precursor; collagen and calcium-binding EGF domain-containing protein 1; full of fluid protein homolog", "tax_id": 10090, "disease": "Hennekam syndrome (Disease Ontology:DOID:0060366)", "pathway": " (mmu:320924)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;21778431;22252499;23426945;35820727;38141283", "class_list": "", "function": "CCBE1 regulates the development and prevents the age-dependent regression of meningeal lymphatics., [RefSeq, PubMed]; Ccbe1 expression marks the cardiac and lymphatic progenitor lineages during early stages of mouse development, [RefSeq, PubMed]; Phenotypic analysis of murine Ccbe1 mutant embryos show a complete lack of definitive lymphatic structures, even though lymphatic endothelial cells are specified within the cardinal vein, [RefSeq, PubMed]; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis., [UniProtKB]; The secreted lymphangiogenic protein CCBE1 is essential for fetal but not postnatal erythropoiesis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A7MCU5;Q5DTT5;Q8BFW1;Q8BMT1", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0005509 calcium ion binding;GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0003016 respiratory system process;GO:0007585 respiratory gaseous exchange by respiratory system;GO:0010575 positive regulation of vascular endothelial growth factor production;GO:0010595 positive regulation of endothelial cell migration;GO:0030324 lung development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3MI99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TQQ9-1", "uniprot_id": "FIRRM_MOUSE", "mass": 101222.0, "length": 903, "protein_name": "FIGNL1-interacting regulator of recombination and mitosis", "gene_name": "Firrm", "organism": "Mouse", "refseq_name": "FIGNL1-interacting regulator of recombination and mitosis isoform 1", "refseq_ac": "NP_958752", "gene_names_uniprotkb": "Firrm; BC055324", "gene_names_refseq": "FLIP; Firrm", "protein_names_uniprotkb": "FIGNL1-interacting regulator of recombination and mitosis; FIDGETIN-like-1 interacting protein; FLIP; POLO1-associating protein", "protein_names_refseq": "FIDGETIN-like-1 interacting protein; FIGNL1-interacting regulator of recombination and mitosis isoform 1; POLO1-associating protein; uncharacterized protein C1orf112 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:381306); (R-MMU-2500257); (R-MMU-5693568); (R-MMU-912446)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "21750661;22872234;23039964;34203471;34428180;37256941;37439366;39147779;39797737", "class_list": "", "function": "BC055324 gene is strongly co-expressed with known cancer-associated genes and with genes involved in the cell cycle. Publication Status: Online-Only, [RefSeq, PubMed]; Forms a complex with FIGL1, which regulates DNA double-strand break (DSB) repair via homologous recombination (HR) (PubMed:37256941, PubMed:37439366). The FIGNL1-FIRRM complex is essential for resolution of homologous recombination intermediates in response to DNA interstrand cross-links (ICLs) (PubMed:37256941, PubMed:37439366). The complex regulates HR by promoting disassembly of RAD51 filaments from DNA and chromatin, thereby preventing DNA damage-independent RAD51 loading and persistent DNA accumulation of RAD51 recombinases (PubMed:37439366). It also regulates HR during meiosis by promoting dissociation of DMC1 filaments from DNA (PubMed:37439366, PubMed:39147779, PubMed:39797737). Within the complex, provides the ATPase activity to disassemble DMC1 and RAD51 filaments, while FIRRM directly binds single-stranded DNA to facilitate this unloading (By similarity). Independently of FIRRM, slso acts as a regulator of PLK1 kinase activity at kinetochores that promotes faithful chromosome segregation in prometaphase by bridging kinase and phosphatase activities (By similarity). Phosphorylation of FIRRM by PLK1 negatively regulates its interaction with the phosphatase, PPP1CC, thus creating a negative feedback loop for maintaining proper PLK1 kinase activity during mitosis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UR98;Q5RKU3;Q7TMQ3", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0051233 spindle midzone;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0036297 interstrand cross-link repair;GO:0045859 regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3TQQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q499E6-1", "uniprot_id": "AIRIM_MOUSE", "mass": 24442.0, "length": 217, "protein_name": "AFG2-interacting ribosome maturation factor", "gene_name": "Airim", "organism": "Mouse", "refseq_name": "AFG2-interacting ribosome maturation factor", "refseq_ac": "NP_808241", "gene_names_uniprotkb": "Airim", "gene_names_refseq": "9930104L06Rik; Airim; C1orf109", "protein_names_uniprotkb": "AFG2-interacting ribosome maturation factor; Ribosome biogenesis protein C1orf109 homolog", "protein_names_refseq": "AFG2-interacting ribosome maturation factor; ribosome biogenesis protein C1orf109 homolog; uncharacterized protein C1orf109 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:194268)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "Part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity. Involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q148T1;Q3TU44;Q8BI05", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0006260 DNA replication;GO:0090069 regulation of ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q499E6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q504N0-1", "uniprot_id": "CBPA2_MOUSE", "mass": 47057.0, "length": 417, "protein_name": "Carboxypeptidase A2", "gene_name": "Cpa2", "organism": "Mouse", "refseq_name": "carboxypeptidase A2 preproprotein", "refseq_ac": "NP_001019869", "gene_names_uniprotkb": "Cpa2", "gene_names_refseq": "Cpa2", "protein_names_uniprotkb": "Carboxypeptidase A2; 3.4.17.15", "protein_names_refseq": "carboxypeptidase A2 preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:232680)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Carboxypeptidase that catalyzes the release of a C-terminal amino acid, with a preference for large aromatic C-terminal residues., [UniProtKB, UniProtKB]; This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein undergoes proteolytic processing that removes the N-terminal activation peptide to generate a functional enzyme. This gene is expressed by the pancreatic exocrine cells which secrete the enzyme during digestion. This gene is located in a cluster of carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004180 carboxypeptidase activity;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q504N0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RJH3-1", "uniprot_id": "CAD12_MOUSE", "mass": 88468.0, "length": 794, "protein_name": "Cadherin-12", "gene_name": "Cdh12", "organism": "Mouse", "refseq_name": "cadherin-12 preproprotein", "refseq_ac": "NP_001008420", "gene_names_uniprotkb": "Cdh12", "gene_names_refseq": "Cdh12; Cdhb", "protein_names_uniprotkb": "Cadherin-12", "protein_names_refseq": "Br-cadherin; cadherin-12 preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:215654); (R-MMU-418990)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;20723620;30899004", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity)., [UniProtKB]; Spatio-temporal mRNA distribution pattern of Cdh12 and Cdh22 during CNS development; demonstrate presence of Cdh12 and Cdh22 mRNA in both excitatory and inhibitory neurons in adult CNS including cerebellum, neocortex, hippocampus and subcortical nuclei, [RefSeq, PubMed]; This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is expressed in both the excitatory and inhibitory neurons in various areas of the adult central nervous system including the cerebellum, neocortex, hippocampus and in different subcortical nuclei. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 15. [provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q5RJH3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SRT8-1", "uniprot_id": "CCNJL_MOUSE", "mass": 43530.0, "length": 387, "protein_name": "Cyclin-J-like protein", "gene_name": "Ccnjl", "organism": "Mouse", "refseq_name": "cyclin-J-like protein isoform 1", "refseq_ac": "NP_001038995", "gene_names_uniprotkb": "Ccnjl; Gm877", "gene_names_refseq": "Ccnjl; Gm877", "protein_names_uniprotkb": "Cyclin-J-like protein", "protein_names_refseq": "cyclin-J-like protein isoform 1; cyclin-J-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:380694)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RTH5", "ec_number_list": "", "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005815 microtubule organizing center;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5SRT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60772-1", "uniprot_id": "CDN2C_MOUSE", "mass": 18066.0, "length": 168, "protein_name": "Cyclin-dependent kinase 4 inhibitor C", "gene_name": "Cdkn2c", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 4 inhibitor C", "refseq_ac": "NP_001288297", "gene_names_uniprotkb": "Cdkn2c", "gene_names_refseq": "Cdkn2c; INK4c; p18-INK4c; p18-INK6; p18INK4c; p18", "protein_names_uniprotkb": "Cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6", "protein_names_refseq": "cyclin-dependent kinase 4 inhibitor C; cyclin-dependent kinase 6 inhibitor; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)", "tax_id": 10090, "disease": "", "pathway": " (mmu:12580)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "37345432;7739547", "class_list": "", "function": "Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB., [UniProtKB]; P18INK4C and BRCA1 inhibit follicular cell proliferation and dedifferentiation in thyroid cancer., [RefSeq, PubMed]; The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase (cdk) inhibitors, and contains five ankyrin repeats. This protein interacts with both Cdk4 and Cdk6 to inhibit their kinase activities, and prevent their interactions with D-type cyclins, thereby negatively regulating cell division. This gene is differentially expressed in a variety of tissues, and is cell cycle regulated. Deletion of this gene can lead to tumor growth. Maximal expression is observed at the G2/M phase. Alternative splicing and promoter usage results in multiple transript variants. [provided by RefSeq, Aug 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0030308 negative regulation of cell growth;GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:2000045 regulation of G1/S transition of mitotic cell cycle;GO:0048709 oligodendrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q60772-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62401-1", "uniprot_id": "CCL12_MOUSE", "mass": 11659.0, "length": 104, "protein_name": "C-C motif chemokine 12", "gene_name": "Ccl12", "organism": "Mouse", "refseq_name": "C-C motif chemokine 12 precursor", "refseq_ac": "NP_035461", "gene_names_uniprotkb": "Ccl12; Mcp5; Scya12", "gene_names_refseq": "Ccl12; MCP-5; Scya12", "protein_names_uniprotkb": "C-C motif chemokine 12; MCP-1-related chemokine; MCP-5; Monocyte chemoattractant protein 5; Monocyte chemotactic protein 5; Small-inducible cytokine A12", "protein_names_refseq": "C-C motif chemokine 12 precursor; C-C motif chemokine 12; MCP-1-related chemokine; chemokine (C-C motif) ligand 12; monocyte chemoattractant protein 5; monocyte chemotactic protein 5; small-inducible cytokine A12", "tax_id": 10090, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stroke (Disease Ontology:DOID:0051061); lupus nephritis (Disease Ontology:DOID:0080162); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); COVID-19 (Disease Ontology:DOID:0080600); Graves ophthalmopathy (Disease Ontology:DOID:0081120); portal hypertension (Disease Ontology:DOID:10762); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); nephritis (Disease Ontology:DOID:10952); IgA vasculitis (Disease Ontology:DOID:11123); allergic conjunctivitis (Disease Ontology:DOID:11204); pneumocystosis (Disease Ontology:DOID:11339); familial hyperlipidemia (Disease Ontology:DOID:1168); gestational diabetes (Disease Ontology:DOID:11714); alcoholic hepatitis (Disease Ontology:DOID:12351); Guillain-Barre syndrome (Disease Ontology:DOID:12842); autistic disorder (Disease Ontology:DOID:12849); cardiovascular system disease (Disease Ontology:DOID:1287); uveitis (Disease Ontology:DOID:13141); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); anterior uveitis (Disease Ontology:DOID:1407); toxic shock syndrome (Disease Ontology:DOID:14115); aggressive periodontitis (Disease Ontology:DOID:1474); cystic fibrosis (Disease Ontology:DOID:1485); fungal infectious disease (Disease Ontology:DOID:1564); thrombocytopenia (Disease Ontology:DOID:1588); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); ischemia (Disease Ontology:DOID:326); bipolar disorder (Disease Ontology:DOID:3312); coronary artery disease (Disease Ontology:DOID:3393); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); macular retinal edema (Disease Ontology:DOID:4449); rhinitis (Disease Ontology:DOID:4483); periapical granuloma (Disease Ontology:DOID:4617); pancreatitis (Disease Ontology:DOID:4989); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); retinal detachment (Disease Ontology:DOID:5327); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); fibromyalgia (Disease Ontology:DOID:631); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); lipodystrophy (Disease Ontology:DOID:811); myocarditis (Disease Ontology:DOID:820); periapical periodontitis (Disease Ontology:DOID:823); ulcerative colitis (Disease Ontology:DOID:8577); skin melanoma (Disease Ontology:DOID:8923); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); viral infectious disease (Disease Ontology:DOID:934); ethmoid sinusitis (Disease Ontology:DOID:9507); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20293); (R-MMU-380108)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10438970;34428180;8920881;8996246", "class_list": "", "function": "Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 66, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYD6", "ec_number_list": "", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0016004 phospholipase activator activity;GO:0031726 CCR1 chemokine receptor binding;GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0001525 angiogenesis;GO:0006954 inflammatory response;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62401-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IR41-1", "uniprot_id": "C1QT6_MOUSE", "mass": 29081.0, "length": 264, "protein_name": "Complement C1q tumor necrosis factor-related protein 6", "gene_name": "C1qtnf6", "organism": "Mouse", "refseq_name": "complement C1q tumor necrosis factor-related protein 6 isoform 1 precursor", "refseq_ac": "NP_082607", "gene_names_uniprotkb": "C1qtnf6", "gene_names_refseq": "2810036M19Rik; Adiq; C1qtnf6; CTRP6", "protein_names_uniprotkb": "Complement C1q tumor necrosis factor-related protein 6", "protein_names_refseq": "adiponectin q; complement C1q tumor necrosis factor-related protein 6 isoform 1 precursor; complement C1q tumor necrosis factor-related protein 6", "tax_id": 10090, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:72709)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;15231994;20102710;21750661;25639984;34632797;35820727;36335445;38103643;38984926", "class_list": "", "function": "CTRP6 alleviates endometrial fibrosis by regulating Smad3 pathway in intrauterine adhesiondagger., [RefSeq, PubMed]; CTRP6 plays a role in fatty acid metabolism via the AMPK-ACC pathway. The globular domain of CTRP6 mediates the phosphorylation and activation of the 5'-AMP-activated protein kinase (AMPK) in skeletal muscle cells. Erratum:[FEBS Lett. 2010 Jun 3;584(11):2491], [RefSeq, PubMed]; CTRP6 promotes the macrophage inflammatory response, and its deficiency attenuates LPS-induced inflammation., [RefSeq, PubMed]; CTRP6 rapidly responds to acute nutritional changes, regulating adipose tissue expansion and inflammation in mice., [RefSeq, PubMed]; CTRP6 suppresses neutrophil extracellular traps formation to ameliorate sepsis-induced lung injury through inactivation of ERK pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown of CTRP6 can inhibit adipogenesis of 3T3-L1 adipocytes through lipogenic marker genes and Erk1/2 signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKR0", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6IR41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPC1-1", "uniprot_id": "CDSN_MOUSE", "mass": 54313.0, "length": 561, "protein_name": "Corneodesmosin", "gene_name": "Cdsn", "organism": "Mouse", "refseq_name": "corneodesmosin isoform 1 precursor", "refseq_ac": "NP_001008424", "gene_names_uniprotkb": "Cdsn", "gene_names_refseq": "Cdsn", "protein_names_uniprotkb": "Corneodesmosin", "protein_names_refseq": "corneodesmosin isoform 1 precursor", "tax_id": 10090, "disease": "peeling skin syndrome 1 (Disease Ontology:DOID:0070520); hypotrichosis 2 (Disease Ontology:DOID:0110699); atopic dermatitis (Disease Ontology:DOID:3310); alopecia (Disease Ontology:DOID:987)", "pathway": " (mmu:386463); (R-MMU-6809371)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "Important for the epidermal barrier integrity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QLN3", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0001533 cornified envelope;GO:0030057 desmosome", "go_biological_process": "GO:1990000 amyloid fibril formation;GO:0098609 cell-cell adhesion;GO:0003336 corneocyte desquamation;GO:0043589 skin morphogenesis;GO:1905716 negative regulation of cornification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TPC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGA7-1", "uniprot_id": "INT15_MOUSE", "mass": 49908.0, "length": 448, "protein_name": "Integrator complex subunit 15", "gene_name": "Ints15", "organism": "Mouse", "refseq_name": "integrator complex subunit 15", "refseq_ac": "NP_766314", "gene_names_uniprotkb": "Ints15", "gene_names_refseq": "A630028N22; E130309D02Rik; Ents15; Ints15", "protein_names_uniprotkb": "Integrator complex subunit 15", "protein_names_refseq": "integrator complex subunit 15; uncharacterized protein C7orf26 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:231868)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "31219806;34428180;36851842", "class_list": "", "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). INTS15 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters. Within the integrator complex, INTS15 is required to bridge different integrator modules., [UniProtKB, UniProtKB]; Integrator complex subunit 15 controls mRNA splicing and is critical for eye development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9D0;Q8BN55", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0032039 integrator complex;GO:0160232 INTAC complex", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0007420 brain development;GO:0000398 mRNA splicing, via spliceosome;GO:0001654 eye development;GO:0160240 RNA polymerase II transcription initiation surveillance", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BGA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C3X2-1", "uniprot_id": "CC90B_MOUSE", "mass": 29597.0, "length": 256, "protein_name": "Coiled-coil domain-containing protein 90B, mitochondrial", "gene_name": "Ccdc90b", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 90B, mitochondrial isoform 2", "refseq_ac": "NP_001156390", "gene_names_uniprotkb": "Ccdc90b", "gene_names_refseq": "2310015N07Rik; Ccdc90b", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 90B, mitochondrial", "protein_names_refseq": "coiled-coil domain-containing protein 90B, mitochondrial isoform 2; coiled-coil domain-containing protein 90B, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:66365)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JZY3;Q9D7C1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8C3X2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C4X1-1", "uniprot_id": "CENPX_MOUSE", "mass": 8926.0, "length": 78, "protein_name": "Centromere protein X", "gene_name": "Cenpx", "organism": "Mouse", "refseq_name": "centromere protein X isoform 2", "refseq_ac": "NP_001334540", "gene_names_uniprotkb": "Cenpx; Faap10; Mhf2; Stra13", "gene_names_refseq": "Cenpx; Stra13", "protein_names_uniprotkb": "Centromere protein X; CENP-X; FANCM-interacting histone fold protein 2; Fanconi anemia-associated polypeptide of 10 kDa; Immediate-early-response protein D9; Retinoic acid-inducible gene D9 protein; Stimulated by retinoic acid gene 13 protein homolog", "protein_names_refseq": "CENP-X; FANCM-interacting histone fold protein 2; Fanconi anemia-associated polypeptide of 10 kDa; centromere protein X isoform 2; immediate-early-response protein D9; retinoic acid-inducible gene D9 protein; stimulated by retinoic acid 13; stimulated by retinoic acid gene 13 protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:20892); (R-MMU-606279); (R-MMU-6783310); (R-MMU-9833482)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "21750661;31219806;8839844", "class_list": "", "function": "DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AC08;O08693;O08694;O08695;Q8BPD7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0071821 FANCM-MHF complex;GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0051382 kinetochore assembly;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0036297 interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C4X1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CC12-1", "uniprot_id": "CDAN1_MOUSE", "mass": 135883.0, "length": 1239, "protein_name": "Codanin-1", "gene_name": "Cdan1", "organism": "Mouse", "refseq_name": "codanin-1", "refseq_ac": "NP_081167", "gene_names_uniprotkb": "Cdan1", "gene_names_refseq": "1500015A01Rik; CDA-I; CDA1; CDAI; Cdan1; codanin-1", "protein_names_uniprotkb": "Codanin-1", "protein_names_refseq": "codanin-1; congenital dyserythropoietic anemia type I; congenital dyserythropoietic anemia, type I", "tax_id": 10090, "disease": "congenital dyserythropoietic anemia type I (Disease Ontology:DOID:0111396); congenital dyserythropoietic anemia type Ia (Disease Ontology:DOID:0111398); congenital dyserythropoietic anemia (Disease Ontology:DOID:1338)", "pathway": " (mmu:68968)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21364188;21750661;34428180;35822049;36852467", "class_list": "", "function": "May act as a negative regulator of ASF1 in chromatin assembly., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AW10;Q149P8;Q3U032", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0060319 primitive erythrocyte differentiation;GO:0001701 in utero embryonic development;GO:0051170 import into nucleus;GO:0000902 cell morphogenesis;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CC12-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CEZ4-1", "uniprot_id": "MB214_MOUSE", "mass": 50535.0, "length": 452, "protein_name": "Protein mab-21-like 4", "gene_name": "Mab21l4", "organism": "Mouse", "refseq_name": "protein mab-21-like 4", "refseq_ac": "NP_001153412", "gene_names_uniprotkb": "Mab21l4", "gene_names_refseq": "2310007B03Rik; Mab21l4", "protein_names_uniprotkb": "Protein mab-21-like 4; Uncharacterized protein C2orf54 homolog", "protein_names_refseq": "protein mab-21-like 4; uncharacterized protein C2orf54 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:71874)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "36852467;40021952", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5FWA3;Q8C4S6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CEZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCT4-1", "uniprot_id": "EST1D_MOUSE", "mass": 61788.0, "length": 565, "protein_name": "Carboxylesterase 1D", "gene_name": "Ces1d", "organism": "Mouse", "refseq_name": "carboxylesterase 1D precursor", "refseq_ac": "NP_444430", "gene_names_uniprotkb": "Ces1d; Ces1; Ces3", "gene_names_refseq": "Ces1d; Ces3; TGH", "protein_names_uniprotkb": "Carboxylesterase 1D; 3.1.1.1; 3.1.1.67; Carboxylesterase 3; FAEE synthase; Fatty acid ethyl ester synthase; TGH; Triacylglycerol hydrolase", "protein_names_refseq": "FAEE synthase; carboxylesterase 1D precursor; carboxylesterase 3; fatty acid ethyl ester synthase; triacylglycerol hydrolase", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); stomach cancer (Disease Ontology:DOID:10534); gastrointestinal system cancer (Disease Ontology:DOID:3119); liver cancer (Disease Ontology:DOID:3571); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:104158); (R-MMU-2022377); (R-MMU-211945); (R-MMU-5578768); (R-MMU-9749641)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10518925;11470237;15220344;15269189;23806337;28011936;30084848;34153284;34428180;35459739;37267638;37453647;37507081;39927985", "class_list": "glycogene", "function": "Adipose tissue-specific ablation of Ces1d causes metabolic dysregulation in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Carboxylesterase 1d (Ces1d) does not contribute to cholesteryl ester hydrolysis in the liver., [RefSeq, PubMed]; Carboxylesterase 3 is an adipocyte lyase, [RefSeq, PubMed]; Major lipase in white adipose tissue. Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters (PubMed:15220344). Hydrolyzes retinyl esters (By similarity)., [UniProtKB, PubMed, UniProtKB]; Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug metabolism and metabolic syndrome development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 36, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91ZV9;Q924V8;Q9ULY1", "ec_number_list": "3.1.1.-;3.1.1.1;3.1.1.23;3.1.1.79;3.1.1.3;3.1.1.88;3.1.1.13;3.1.1.67;3.1.1.28", "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0052689 carboxylic ester hydrolase activity;GO:0004806 triacylglycerol lipase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0030339 fatty-acyl-ethyl-ester synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0070417 cellular response to cold;GO:0060086 circadian temperature homeostasis;GO:0006637 acyl-CoA metabolic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8VCT4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDY9-1", "uniprot_id": "CAAP1_MOUSE", "mass": 37825.0, "length": 356, "protein_name": "Caspase activity and apoptosis inhibitor 1", "gene_name": "Caap1", "organism": "Mouse", "refseq_name": "caspase activity and apoptosis inhibitor 1 isoform 1", "refseq_ac": "NP_080644", "gene_names_uniprotkb": "Caap1; Caap", "gene_names_refseq": "5830433M19Rik; CAAP; Caap1", "protein_names_uniprotkb": "Caspase activity and apoptosis inhibitor 1; CAAP; Conserved anti-apoptotic protein", "protein_names_refseq": "caspase activity and apoptosis inhibitor 1 isoform 1; conserved anti-apoptotic protein; likely ortholog of H. sapiens chromosome 9 open reading frame 82 (C9orf82)", "tax_id": 10090, "disease": "", "pathway": " (mmu:67770)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17242355;21183079;30629682;34428180", "class_list": "", "function": "Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop., [UniProtKB]; C9orf82ko/ko mice were born at a Mendelian ratio and did not display any overt macroscopic or histological abnormalities. DNA double-strand breaks repair dependent processes like lymphocyte development and class switch recombination (CSR) appeared normal, arguing against a link between the C9orf82 encoded protein and V(D)J recombination or CSR. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3USG8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VDY9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V98-1", "uniprot_id": "CD248_MOUSE", "mass": 81813.0, "length": 765, "protein_name": "Endosialin", "gene_name": "Cd248", "organism": "Mouse", "refseq_name": "endosialin precursor", "refseq_ac": "NP_473383", "gene_names_uniprotkb": "Cd248; Tem1", "gene_names_refseq": "2610111G01Rik; Cd164l1; Cd248; Tem1", "protein_names_uniprotkb": "Endosialin; Tumor endothelial marker 1", "protein_names_refseq": "CD164 sialomucin-like 1; endosialin precursor; endosialin; tumor endothelial marker 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70445)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;11489895;11559528;16492758;16965941;21183079;25243742;25428506;30084848;30986375;33737161;33830628;34428180;37828378;38061240;38396325;39113704", "class_list": "glycogene", "function": "Cell surface glycoprotein involved in various biological processes including angiogenesis, immune response modulation, and tissue remodeling and repair (PubMed:11489895, PubMed:25243742, PubMed:38061240). Participates in pericyte proliferation through positive modulation of the PDGF receptor signaling pathway (PubMed:30986375). Acts as a scaffold for factor X, triggering allosteric changes and the spatial re-alignment of factor X with the TF-factor VIIa complex, thereby enhancing coagulation activation (PubMed:33830628). Modulates the insulin signaling pathway by interacting with insulin receptor/INSR and by diminishing its capacity to be autophosphorylated in response to insulin (PubMed:38061240). Also regulates LPS-induced inflammatory responses in macrophages by favoring production of proinflammatory cytokines (PubMed:33737161)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer., [RefSeq, PubMed]; In the embryo when analysed by confocal microscopy endosialin on vessels does not colocalise with endothelial cells expressing CD31, rather, endosialin is restricted to closely associated perivascular cells that also express the pericyte marker NG2., [RefSeq, PubMed]; Regulation of matrix reloading by tumor endothelial marker 1 protects against abdominal aortic aneurysm. Publication Status: Online-Only, [RefSeq, PubMed]; Tem1 have significant implications for the mechanisms underlying tumor invasiveness and for models that evaluate this process, [RefSeq, PubMed]", "predicted_glycosites": 30, "predicted_n_glycosites": 0, "predicted_o_glycosites": 30, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 35, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 31, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMV6;Q91ZV1", "ec_number_list": "", "go_molecular_function": "GO:1990430 extracellular matrix protein binding;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration;GO:2000353 positive regulation of endothelial cell apoptotic process;GO:0048535 lymph node development;GO:0060033 anatomical structure regression", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q91V98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZW8-1", "uniprot_id": "C209D_MOUSE", "mass": 26925.0, "length": 237, "protein_name": "CD209 antigen-like protein D", "gene_name": "Cd209d", "organism": "Mouse", "refseq_name": "CD209 antigen-like protein D", "refseq_ac": "NP_570974", "gene_names_uniprotkb": "Cd209d", "gene_names_refseq": "Cd209d; SIGN-R3; SIGNR3; mSIGNR3", "protein_names_uniprotkb": "CD209 antigen-like protein D; DC-SIGN-related protein 3; DC-SIGNR3", "protein_names_refseq": "C-type lectin; CD209 antigen-like protein D; DC-SIGN-related protein 3; DC-SIGNR3; dendritic cell surface protein; type II transmembrane protein", "tax_id": 10090, "disease": "extrapulmonary tuberculosis (Disease Ontology:DOID:0050598); rheumatic heart disease (Disease Ontology:DOID:0050827); Coronavirus infectious disease (Disease Ontology:DOID:0080599); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); dengue disease (Disease Ontology:DOID:12205); dengue hemorrhagic fever (Disease Ontology:DOID:12206); aspergillosis (Disease Ontology:DOID:13564); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); tuberculosis (Disease Ontology:DOID:399); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:170779)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11581173;28587925;34956169", "class_list": "glycogene", "function": "Lactobacillus acidophilus Supplementation Exerts a Synergistic Effect on Tacrolimus Efficacy by Modulating Th17/Treg Balance in Lupus-Prone Mice via the SIGNR3 Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens., [UniProtKB]; The sum of the data suggests that in contrast to IgG-based immune complexes boosting immune reactivity of antigen-presenting cells, secretory IgA produced during an ongoing immune response can, in addition to its known function of immune exclusion, modulate mucosal dendritic cell conditioning via specific interaction with Dectin-1 and SIGNR3., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VIK4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0048306 calcium-dependent protein binding;GO:0001618 virus receptor activity;GO:0005537 D-mannose binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0006955 immune response;GO:0001819 positive regulation of cytokine production;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91ZW8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JP4-1", "uniprot_id": "CDC26_MOUSE", "mass": 9761.0, "length": 85, "protein_name": "Anaphase-promoting complex subunit CDC26", "gene_name": "Cdc26", "organism": "Mouse", "refseq_name": "anaphase-promoting complex subunit CDC26", "refseq_ac": "NP_647452", "gene_names_uniprotkb": "Cdc26", "gene_names_refseq": "2010012C09Rik; Cdc26", "protein_names_uniprotkb": "Anaphase-promoting complex subunit CDC26; Cell division cycle protein 26 homolog", "protein_names_refseq": "CDC26 subunit of anaphase promoting complex; anaphase-promoting complex subunit CDC26; cell division cycle protein 26 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66440); (R-MMU-141430); (R-MMU-174048); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-176407); (R-MMU-176408); (R-MMU-176409); (R-MMU-176412); (R-MMU-179409); (R-MMU-2467813); (R-MMU-2559582); (R-MMU-68867); (R-MMU-69017); (R-MMU-983168)", "pathway_count": 17, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). Together with the RING-H2 protein ANAPC11, forms the catalytic component of the E3 ubiquitin ligase complex (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity). May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q99JP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQF4-1", "uniprot_id": "MRES1_MOUSE", "mass": 27847.0, "length": 240, "protein_name": "Mitochondrial transcription rescue factor 1", "gene_name": "Mtres1", "organism": "Mouse", "refseq_name": "mitochondrial transcription rescue factor 1", "refseq_ac": "NP_080687", "gene_names_uniprotkb": "Mtres1", "gene_names_refseq": "1700021F05Rik; Mtres1", "protein_names_uniprotkb": "Mitochondrial transcription rescue factor 1", "protein_names_refseq": "mitochondrial transcription rescue factor 1; uncharacterized protein C6orf203 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67851)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;17114649;17242355;18630941;21183079", "class_list": "", "function": "Mitochondrial RNA-binding protein involved in mitochondrial transcription regulation. Functions as a protective factor to maintain proper mitochondrial RNA level during stress. Acts at the transcription level and its protective function depends on its RNA binding ability. Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation. As heterodimer with MTRF, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQU4", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0000049 tRNA binding;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0006351 DNA-templated transcription;GO:1903108 regulation of mitochondrial transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CQF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR92-1", "uniprot_id": "CF184_MOUSE", "mass": 67256.0, "length": 584, "protein_name": "Cilia- and flagella-associated protein 184", "gene_name": "Cfap184", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 184", "refseq_ac": "NP_080001", "gene_names_uniprotkb": "Cfap184; Ccdc96", "gene_names_refseq": "4921513E08Rik; Ccdc96; Cfap184", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 184", "protein_names_refseq": "cilia- and flagella-associated protein 184; coiled-coil domain containing 96; coiled-coil domain-containing protein 96", "tax_id": 10090, "disease": "", "pathway": " (mmu:66717)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "In complex with CFAP263, acts as a regulator of ciliary beating that connects radial spoke 3 (RS3) to the inner dynein arm (IDA) and the nexin-dynein regulatory complex (N-DRC). The complex is positioned parallel to N-DRC and forms a connection between the arch at the base of RS3, the IDA tail and N-DRC., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005930 axoneme;GO:0036064 ciliary basal body", "go_biological_process": "GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CR92-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CRW3-1", "uniprot_id": "CB076_MOUSE", "mass": 14588.0, "length": 126, "protein_name": "UPF0538 protein C2orf76 homolog", "gene_name": "3110009E18Rik", "organism": "Mouse", "refseq_name": "UPF0538 protein C2orf76 homolog isoform 2", "refseq_ac": "NP_001165545", "gene_names_uniprotkb": "3110009E18Rik", "gene_names_refseq": "3110009E18Rik", "protein_names_uniprotkb": "UPF0538 protein C2orf76 homolog", "protein_names_refseq": "UPF0538 protein C2orf76 homolog isoform 2; UPF0538 protein C2orf76 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:73103)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K163", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CRW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWQ8-1", "uniprot_id": "CAST1_MOUSE", "mass": 36575.0, "length": 331, "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 1", "gene_name": "Castor1", "organism": "Mouse", "refseq_name": "cytosolic arginine sensor for mTORC1 subunit 1", "refseq_ac": "NP_082298", "gene_names_uniprotkb": "Castor1; Gatsl3", "gene_names_refseq": "2410008K03Rik; Castor1; Gatsl3", "protein_names_uniprotkb": "Cytosolic arginine sensor for mTORC1 subunit 1; GATS-like protein 3", "protein_names_refseq": "GATS protein-like 3; GATS-like protein 3; cytosolic arginine sensor for mTORC1 subunit 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71962); (R-MMU-9639288)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "34428180;36170813", "class_list": "", "function": "Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway., [UniProtKB, UniProtKB]; Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29R56", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0034618 arginine binding;GO:0140299 molecular sensor activity;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005829 cytosol;GO:0061700 GATOR2 complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0031669 cellular response to nutrient levels;GO:0034198 cellular response to amino acid starvation;GO:1903577 cellular response to L-arginine;GO:1904262 negative regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CWQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CYS6-1", "uniprot_id": "CB072_MOUSE", "mass": 30320.0, "length": 286, "protein_name": "Uncharacterized protein C2orf72 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C2orf72 homolog isoform 2", "refseq_ac": "NP_001138465", "gene_names_uniprotkb": "", "gene_names_refseq": "2810459M11Rik", "protein_names_uniprotkb": "Uncharacterized protein C2orf72 homolog", "protein_names_refseq": "uncharacterized protein C2orf72 homolog isoform 2; uncharacterized protein C2orf72 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:72792)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RPZ8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CYS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D5D8-1", "uniprot_id": "CDYL2_MOUSE", "mass": 56142.0, "length": 503, "protein_name": "Chromodomain Y-like protein 2", "gene_name": "Cdyl2", "organism": "Mouse", "refseq_name": "chromodomain Y-like protein 2", "refseq_ac": "NP_083717", "gene_names_uniprotkb": "Cdyl2", "gene_names_refseq": "1700029M19Rik; 4930453I21Rik; Cdyl2; Gm20194", "protein_names_uniprotkb": "Chromodomain Y-like protein 2; CDY-like 2", "protein_names_refseq": "CDY-like 2; chromodomain Y-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:75796)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18450745;25428506;27802388;30779550;31219806;34428180;36210013", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0061628 histone H3K27me3 reader activity;GO:0062072 histone H3K9me2/3 reader activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D5D8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9D9-1", "uniprot_id": "CP141_MOUSE", "mass": 12258.0, "length": 101, "protein_name": "Cilia- and flagella-associated protein 141", "gene_name": "Cfap141", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 141", "refseq_ac": "NP_082843", "gene_names_uniprotkb": "Cfap141", "gene_names_refseq": "1700094D03Rik; Cfap141", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 141", "protein_names_refseq": "cilia- and flagella-associated protein 141; protein CFAP141; uncharacterized protein C1orf189 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:73545)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "37295417;37865089;37989994", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D9D9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9H8-1", "uniprot_id": "CB069_MOUSE", "mass": 41689.0, "length": 365, "protein_name": "Mitochondrial protein C2orf69 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "mitochondrial protein C2orf69 homolog precursor", "refseq_ac": "NP_082822", "gene_names_uniprotkb": "", "gene_names_refseq": "1700066M21Rik", "protein_names_uniprotkb": "Mitochondrial protein C2orf69 homolog", "protein_names_refseq": "UPF0565 protein C2orf69 homolog; mitochondrial protein C2orf69 homolog precursor; mitochondrial protein C2orf69 homolog", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 53 (Disease Ontology:DOID:0070426)", "pathway": " (mmu:73467)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10.1101/2023.09.13.557529", "class_list": "", "function": "May play a role in the respiratory chain., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9896, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QNR4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006119 oxidative phosphorylation;GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D9H8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAD0-1", "uniprot_id": "CF276_MOUSE", "mass": 18931.0, "length": 168, "protein_name": "Cilia- and flagella-associated protein 276", "gene_name": "Cfap276", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 276", "refseq_ac": "NP_083590", "gene_names_uniprotkb": "Cfap276", "gene_names_refseq": "1700013F07Rik; Cfap276", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 276", "protein_names_refseq": "cilia- and flagella-associated protein 276; protein CFAP276; uncharacterized protein C1orf194 homolog", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease intermediate type (Disease Ontology:DOID:0050543)", "pathway": " (mmu:75504)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "31199454;37295417;37865089;37989994", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:37295417, PubMed:37865089, PubMed:37989994). May play an important role for the maintenance of myelin-axon integrity (PubMed:31199454). May affect intracellular Ca(2+) homeostasis (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160112 axonemal B tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DAD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAF8-1", "uniprot_id": "CD051_MOUSE", "mass": 23497.0, "length": 208, "protein_name": "Uncharacterized protein C4orf51 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C4orf51 homolog", "refseq_ac": "NP_080591", "gene_names_uniprotkb": "", "gene_names_refseq": "1700011L22Rik", "protein_names_uniprotkb": "Uncharacterized protein C4orf51 homolog", "protein_names_refseq": "uncharacterized protein C4orf51 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67687)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X910", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9DAF8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIA9-1", "uniprot_id": "CATR_MOUSE", "mass": 37421.0, "length": 334, "protein_name": "Cathepsin R", "gene_name": "Ctsr", "organism": "Mouse", "refseq_name": "cathepsin R precursor", "refseq_ac": "NP_064680", "gene_names_uniprotkb": "Ctsr; Catr", "gene_names_refseq": "Ctsr", "protein_names_uniprotkb": "Cathepsin R; 3.4.22.-", "protein_names_refseq": "cathepsin R precursor; lysosomal cysteine protease", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:56835)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11004518;11829493;15514457;16097084;40885482", "class_list": "", "function": "Chromosome mapping of this enzyme in mouse placenta., [RefSeq, PubMed]; Possible association of cathepsins with placental lactogen-II may play important roles in placental functions during the latter half of pregnancy in mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:0030163 protein catabolic process;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JIA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WU84-1", "uniprot_id": "CCS_MOUSE", "mass": 28912.0, "length": 274, "protein_name": "Copper chaperone for superoxide dismutase", "gene_name": "Ccs", "organism": "Mouse", "refseq_name": "copper chaperone for superoxide dismutase", "refseq_ac": "NP_058588", "gene_names_uniprotkb": "Ccs; Ccsd", "gene_names_refseq": "Ccsd; Ccs", "protein_names_uniprotkb": "Copper chaperone for superoxide dismutase; Superoxide dismutase copper chaperone", "protein_names_refseq": "copper chaperone for superoxide dismutase; superoxide dismutase copper chaperone", "tax_id": 10090, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003); neurodegenerative disease (Disease Ontology:DOID:1289); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:12460); (R-MMU-3299685)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10694572;10773661;21183079;21750661;21927927;25428506;30084848;30779550;31219806;34428180;35820727", "class_list": "", "function": "Delivers copper to copper zinc superoxide dismutase (SOD1)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems., [UniProtKB, UniProtKB]; Results suggest that a SOD1 supplement to healthy mice may not be necessary to modulate cell proliferation and neuroblast differentiation in the dentate gyrus, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CRJ9", "ec_number_list": "1.15.1.1;1.8.-.-;1.11.1.-;1.7.-.-;1.14.12.-", "go_molecular_function": "GO:0019899 enzyme binding;GO:0005507 copper ion binding;GO:0016532 superoxide dismutase copper chaperone activity;GO:0046872 metal ion binding;GO:0004784 superoxide dismutase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0051353 positive regulation of oxidoreductase activity;GO:0019430 removal of superoxide radicals;GO:0006801 superoxide metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9WU84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEG0-1", "uniprot_id": "CCD71_MOUSE", "mass": 46010.0, "length": 433, "protein_name": "Coiled-coil domain-containing protein 71", "gene_name": "Ccdc71", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 71", "refseq_ac": "NP_598505", "gene_names_uniprotkb": "Ccdc71", "gene_names_refseq": "2600016J21Rik; Ccdc71", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 71", "protein_names_refseq": "coiled-coil domain-containing protein 71", "tax_id": 10090, "disease": "", "pathway": " (mmu:72454)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDX1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VEG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35457-1", "uniprot_id": "CCRL2_MOUSE", "mass": 40745.0, "length": 360, "protein_name": "C-C chemokine receptor-like 2", "gene_name": "Ccrl2", "organism": "Mouse", "refseq_name": "C-C chemokine receptor-like 2", "refseq_ac": "NP_001289305", "gene_names_uniprotkb": "Ccrl2; Ccr11; Lccr", "gene_names_refseq": "1810047I05Rik; Ackr5; CCR11; Ccrl2; Cmkbr1l2; E01; L-CCR", "protein_names_uniprotkb": "C-C chemokine receptor-like 2; Chemokine receptor CCR11; G protein-coupled beta chemokine receptor; L-CCR; Lipopolysaccharide-inducible C-C chemokine receptor", "protein_names_refseq": "C-C chemokine receptor-like 2; G-protein coupled beta chemokine receptor; chemokine (C-C motif) receptor-like 2; chemokine (C-C) receptor 1-like 2; chemokine receptor CCR11; lipopolysaccharide inducible C-C chemokine receptor related; lipopolysaccharide-inducible C-C chemokine receptor; lipopolysacharide-inducible C-C chemokine receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:54199); (R-MMU-380108)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12555200;12885941;14966207;14999816;18794339;20606167;21750661;30084848;31599954;37279540;38556341;9563519", "class_list": "", "function": "Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent beta2 integrin activation in monocytes., [RefSeq, PubMed]; Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptor. Plays a critical role for the development of Th2 responses (By similarity)., [UniProtKB, PubMed, PubMed, PubMed]; Role of CCRL2 in the Pathogenesis of Experimental Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3 Pathway., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O70171;Q3UKM6;Q4FK04;Q91YD7", "ec_number_list": "", "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0042379 chemokine receptor binding;GO:0048020 CCR chemokine receptor binding;GO:0004950 chemokine receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O35457-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60773-1", "uniprot_id": "CDN2D_MOUSE", "mass": 17809.0, "length": 166, "protein_name": "Cyclin-dependent kinase 4 inhibitor D", "gene_name": "Cdkn2d", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 4 inhibitor D isoform 1", "refseq_ac": "NP_034008", "gene_names_uniprotkb": "Cdkn2d", "gene_names_refseq": "Cdkn2d; INK4d; p19INK4d; p19", "protein_names_uniprotkb": "Cyclin-dependent kinase 4 inhibitor D; p19-INK4d", "protein_names_refseq": "cyclin-dependent kinase 4 inhibitor D isoform 1; cyclin-dependent kinase 4 inhibitor D; cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); p19-INK4d", "tax_id": 10090, "disease": "", "pathway": " (mmu:12581)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;34428180;7739547;7739548;9353127", "class_list": "", "function": "Interacts strongly with CDK4 and CDK6 and inhibits them., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60794;Q91YV3", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0097129 cyclin D2-CDK4 complex", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0032526 response to retinoic acid;GO:0030308 negative regulation of cell growth;GO:0009411 response to UV", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q60773-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04235-1", "uniprot_id": "CD3D_MOUSE", "mass": 19032.0, "length": 173, "protein_name": "T-cell surface glycoprotein CD3 delta chain", "gene_name": "Cd3d", "organism": "Mouse", "refseq_name": "T-cell surface glycoprotein CD3 delta chain precursor", "refseq_ac": "NP_038515", "gene_names_uniprotkb": "Cd3d; T3d", "gene_names_refseq": "Cd3d; T3d", "protein_names_uniprotkb": "T-cell surface glycoprotein CD3 delta chain; T-cell receptor T3 delta chain", "protein_names_refseq": "T-cell receptor T3 delta chain; T-cell surface glycoprotein CD3 delta chain precursor; T-cell surface glycoprotein CD3 delta chain", "tax_id": 10090, "disease": "immunodeficiency 19 (Disease Ontology:DOID:0111972); severe combined immunodeficiency (Disease Ontology:DOID:627)", "pathway": " (mmu:12500); (R-MMU-198933); (R-MMU-202424); (R-MMU-202427); (R-MMU-202430); (R-MMU-202433); (R-MMU-389948); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 9, "publication_count": 7, "publication_id_list": "10935641;15459203;21750661;2827170;28441398;2939461;34428180", "class_list": "", "function": "Mutation of Cd3d not only impairs the proper development of amacrine cells expressing Cd3d but also those not expressing Cd3d . In contrast to effects of Major histocompatibility complex and its receptor, PirB, on other neurons, mutation of Cd3d has no effect on retinal ganglion cells death and starburst amacrine cells degeneration after optic nerve crush. Erratum:[PLoS One. 2018 Jun 1;13(6):e0198770. doi: 10.1371/journal.pone.0198770. PMID: 29856870] Publication Status: Online-Only, [RefSeq, PubMed]; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly (PubMed:10935641). Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0032395 MHC class II receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042101 T cell receptor complex;GO:0009897 external side of plasma membrane;GO:0042105 alpha-beta T cell receptor complex", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0042110 T cell activation;GO:0050852 T cell receptor signaling pathway;GO:0002250 adaptive immune response;GO:0045059 positive thymic T cell selection", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P04235-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A6Q5-1", "uniprot_id": "CDC27_MOUSE", "mass": 91842.0, "length": 825, "protein_name": "Cell division cycle protein 27 homolog", "gene_name": "Cdc27", "organism": "Mouse", "refseq_name": "cell division cycle protein 27 homolog isoform 1", "refseq_ac": "NP_001272917", "gene_names_uniprotkb": "Cdc27", "gene_names_refseq": "APC3; Cdc27", "protein_names_uniprotkb": "Cell division cycle protein 27 homolog", "protein_names_refseq": "Cell division cycle protein 27 homolog; cell division cycle 27 homolog; cell division cycle protein 27 homolog isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:217232); (R-MMU-141430); (R-MMU-174048); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-176407); (R-MMU-176408); (R-MMU-176409); (R-MMU-176412); (R-MMU-179409); (R-MMU-2467813); (R-MMU-2559582); (R-MMU-68867); (R-MMU-69017); (R-MMU-983168)", "pathway_count": 17, "publication_count": 4, "publication_id_list": "20716133;25428506;31219806;34428180", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A6Q6;B2RXS0", "ec_number_list": "", "go_molecular_function": "GO:0019903 protein phosphatase binding;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0031175 neuron projection development;GO:0051301 cell division;GO:0016567 protein ubiquitination;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2A6Q5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58019-1", "uniprot_id": "CD59B_MOUSE", "mass": 14227.0, "length": 129, "protein_name": "CD59B glycoprotein", "gene_name": "Cd59b", "organism": "Mouse", "refseq_name": "CD59B glycoprotein precursor", "refseq_ac": "NP_862906", "gene_names_uniprotkb": "Cd59b", "gene_names_refseq": "Cd59b", "protein_names_uniprotkb": "CD59B glycoprotein; MAC-IP; MAC-inhibitory protein; MACIF; Membrane attack complex inhibition factor; Protectin", "protein_names_refseq": "CD59B glycoprotein precursor; CD59B glycoprotein; MAC-IP; MAC-inhibitory protein; MACIF; membrane attack complex inhibition factor; protectin", "tax_id": 10090, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); colorectal carcinoma (Disease Ontology:DOID:0080199); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); endometrial cancer (Disease Ontology:DOID:1380); anterior uveitis (Disease Ontology:DOID:1407); ovarian cancer (Disease Ontology:DOID:2394); nephrosis (Disease Ontology:DOID:2527); glomerulonephritis (Disease Ontology:DOID:2921); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); myocardial infarction (Disease Ontology:DOID:5844); neuromyelitis optica (Disease Ontology:DOID:8869); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:333883); (R-MMU-204005); (R-MMU-5694530); (R-MMU-6798695); (R-MMU-6807878); (R-MMU-977606)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10946279;11471050;12594949;21750661;27729184;30084848", "class_list": "", "function": "Cd59b knockout mice present a phenotype characterized by hemolytic anemia, platelet activation and a progressive loss of fertility associated with immobile dysmorphic and fewer sperm cells after 5 months of age., [RefSeq, PubMed]; Data (including data from studies using knockout mice) suggest that CD59a, CD59b, and ApoE are involved in development of diabetes-induced atherosclerosis; here, deficiency of CD59a/CD59b (in ApoE deficient mice) accelerates development of atherosclerosis in mice with type 1 diabetes. (CD59a = CD59a antigen; CD59b = CD59b antigen; ApoE = apolipoprotein E), [RefSeq, PubMed]; Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59b., [RefSeq, PubMed]; Potent inhibitor of the complement membrane attack complex (MAC) action, which protects self-cells from damage during complement activation. Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q920G7", "ec_number_list": "", "go_molecular_function": "GO:0001848 complement binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0042102 positive regulation of T cell proliferation;GO:0045916 negative regulation of complement activation;GO:0006956 complement activation;GO:0001971 negative regulation of activation of membrane attack complex", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P58019-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13379-1", "uniprot_id": "CD5_MOUSE", "mass": 53849.0, "length": 494, "protein_name": "T-cell surface glycoprotein CD5", "gene_name": "Cd5", "organism": "Mouse", "refseq_name": "T-cell surface glycoprotein CD5 precursor", "refseq_ac": "NP_031676", "gene_names_uniprotkb": "Cd5; Ly-1", "gene_names_refseq": "Cd5; Ly-12; Ly-1; Ly-A; Lyt-1", "protein_names_uniprotkb": "T-cell surface glycoprotein CD5; Ly-1; Lymphocyte antigen 1; Lyt-1", "protein_names_refseq": "T-cell surface glycoprotein CD5 precursor; T-cell surface glycoprotein CD5; lymphocyte antigen 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12507)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11007759;11157848;21183079;21750661;24950378;3025855;34428180;35720357;35820727;36002232;7536775;9064341;9723705", "class_list": "", "function": "Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance (PubMed:35720357). Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis (PubMed:24950378, PubMed:9064341, PubMed:9723705). Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL (PubMed:11157848). Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (By similarity). Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0031295 T cell costimulation;GO:0097190 apoptotic signaling pathway;GO:0050859 negative regulation of B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P13379-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14097-1", "uniprot_id": "CCL4_MOUSE", "mass": 10168.0, "length": 92, "protein_name": "C-C motif chemokine 4", "gene_name": "Ccl4", "organism": "Mouse", "refseq_name": "C-C motif chemokine 4 precursor", "refseq_ac": "NP_038680", "gene_names_uniprotkb": "Ccl4; Mip1b; Scya4", "gene_names_refseq": "AT744.1; Act-2; Ccl4; MIP-1B; Mip1b; Scya4", "protein_names_uniprotkb": "C-C motif chemokine 4; ACT-2; ACT2; Immune activation protein 2; MIP-1-beta; Macrophage inflammatory protein 1-beta; Protein H400; SIS-gamma; Small-inducible cytokine A4", "protein_names_refseq": "ACT2; C-C motif chemokine 4 precursor; C-C motif chemokine 4; MIP-1-beta; SIS-gamma; chemokine (C-C motif) ligand 4; immune activation protein 2; macrophage inflammatory protein 1-beta; small-inducible cytokine A4", "tax_id": 10090, "disease": "sinusitis (Disease Ontology:DOID:0050127); COVID-19 (Disease Ontology:DOID:0080600); dry eye syndrome (Disease Ontology:DOID:10140); viral pneumonia (Disease Ontology:DOID:10533); mastitis (Disease Ontology:DOID:10690); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); cystic fibrosis (Disease Ontology:DOID:1485); status epilepticus (Disease Ontology:DOID:1824); hepatitis B (Disease Ontology:DOID:2043); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); autoimmune disease (Disease Ontology:DOID:417); systemic scleroderma (Disease Ontology:DOID:418); rhinitis (Disease Ontology:DOID:4483); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); septic arthritis (Disease Ontology:DOID:813); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074); visceral leishmaniasis (Disease Ontology:DOID:9146); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20303); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10438970;2521353;3058856;33630763;36863097;37175837", "class_list": "", "function": "Macrophage inflammatory protein-1beta as a novel therapeutic target for renal protection in diabetic kidney disease., [RefSeq, PubMed]; Monokine with inflammatory and chemokinetic properties., [UniProtKB]; Murine Placental Erythroid Cells Are Mainly Represented by CD45[+] Immunosuppressive Erythroid Cells and Secrete CXCL1, CCL2, CCL3 and CCL4 Chemokines. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031726 CCR1 chemokine receptor binding;GO:0031730 CCR5 chemokine receptor binding;GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway;GO:0071466 cellular response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P14097-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55271-1", "uniprot_id": "CDN2B_MOUSE", "mass": 13789.0, "length": 130, "protein_name": "Cyclin-dependent kinase 4 inhibitor B", "gene_name": "Cdkn2b", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 4 inhibitor B", "refseq_ac": "NP_031696", "gene_names_uniprotkb": "Cdkn2b", "gene_names_refseq": "Cdkn2b; INK4b; MTS2; p15(INK4b); p15INK4b; p15", "protein_names_uniprotkb": "Cyclin-dependent kinase 4 inhibitor B; p14-INK4b; p15-INK4b", "protein_names_refseq": "cyclin-dependent kinase 4 inhibitor B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinase inhibitor p15INK4b; cyclin-dependent kinase inhibitor protein; p14-INK4b; p15-INK4b", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); primary cutaneous T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0060061); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); chronic myelomonocytic leukemia (Disease Ontology:DOID:0080188); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); melanoma and neural system tumor syndrome (Disease Ontology:DOID:0111511); dysplastic nevus syndrome (Disease Ontology:DOID:10041); prostate cancer (Disease Ontology:DOID:10283); open-angle glaucoma (Disease Ontology:DOID:1067); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); leukemia (Disease Ontology:DOID:1240); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); leiomyosarcoma (Disease Ontology:DOID:1967); nephroblastoma (Disease Ontology:DOID:2154); transitional cell carcinoma (Disease Ontology:DOID:2671); granulosa cell tumor (Disease Ontology:DOID:2999); invasive ductal carcinoma (Disease Ontology:DOID:3008); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); neurilemmoma (Disease Ontology:DOID:3192); germinoma (Disease Ontology:DOID:3304); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); renal cell carcinoma (Disease Ontology:DOID:4450); pancreatic carcinoma (Disease Ontology:DOID:4905); cholangiocarcinoma (Disease Ontology:DOID:4947); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); uterine carcinosarcoma (Disease Ontology:DOID:6171); hepatocellular carcinoma (Disease Ontology:DOID:684); familial melanoma (Disease Ontology:DOID:6846); neuroblastoma (Disease Ontology:DOID:769); chronic myeloid leukemia (Disease Ontology:DOID:8552); in situ carcinoma (Disease Ontology:DOID:8719); erythema infectiosum (Disease Ontology:DOID:8743); skin melanoma (Disease Ontology:DOID:8923); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:12579); (R-MMU-2559580); (R-MMU-2559582); (R-MMU-2559585); (R-MMU-69231)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "10556039;15345747;33900379;7651726;9178896", "class_list": "", "function": "B-cell receptor signaling and genetic lesions in TP53 and CDKN2A/CDKN2B cooperate in Richter transformation., [RefSeq, PubMed]; Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 47, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051059 NF-kappaB binding;GO:0002039 p53 binding;GO:0019789 SUMO transferase activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0031670 cellular response to nutrient;GO:0008285 negative regulation of cell population proliferation;GO:0050680 negative regulation of epithelial cell proliferation;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P55271-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56484-1", "uniprot_id": "CCR8_MOUSE", "mass": 40045.0, "length": 353, "protein_name": "C-C chemokine receptor type 8", "gene_name": "Ccr8", "organism": "Mouse", "refseq_name": "C-C chemokine receptor type 8", "refseq_ac": "NP_031746", "gene_names_uniprotkb": "Ccr8; Cmkbr8; Ter1", "gene_names_refseq": "C-C CKR-8; C-C; CC-CKR-8; CCR-8; CKR-8; Ccr8; Cmkbr8; mCCR8", "protein_names_uniprotkb": "C-C chemokine receptor type 8; C-C CKR-8; CC-CKR-8; CCR-8", "protein_names_refseq": "C-C chemokine receptor type 8; chemokine (C-C motif) receptor 8", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841); pulmonary fibrosis (Disease Ontology:DOID:3770)", "pathway": " (mmu:12776); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11238588;12050188;33613532;35140181;37921466;9469461;9670926", "class_list": "", "function": "CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory., [RefSeq, PubMed]; Cutting Edge: CCR8 Signaling Regulates IL-25- and IL-33-Responsive Skin Group 2 Innate Lymphoid Cell Migration and Function., [RefSeq, PubMed]; G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18 (PubMed:9469461). Regulates monocyte and eosinophil chemotaxis (PubMed:11238588). Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways (By similarity). Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage by supporting lymphoid cells IFN-gamma production (PubMed:33613532)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Mediates increased responsiveness of murine eosinophils to TCA-3, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0006955 immune response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P56484-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56528-1", "uniprot_id": "CD38_MOUSE", "mass": 34408.0, "length": 304, "protein_name": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1", "gene_name": "Cd38", "organism": "Mouse", "refseq_name": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1", "refseq_ac": "NP_031672", "gene_names_uniprotkb": "Cd38", "gene_names_refseq": "ADPRC 1; Cd38-rs1; Cd38; I-19", "protein_names_uniprotkb": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cyclic-ADP-ribose transferase; 2.4.99.20; 3.2.2.-; 3.2.2.6; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; I-19; NIM-R5 antigen; cADPR hydrolase 1", "protein_names_refseq": "2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; NIM-R5 antigen; cADPr hydrolase 1; cyclic ADP-ribose hydrolase 1", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12494); (R-MMU-196807)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11829748;19224205;20173027;22863568;30899004;34428180;37507081;8376770", "class_list": "", "function": "Multifunctional transmembrane glycoprotein able to exert enzymatic activities and also to mobilize calcium, to transduce signals, to adhere to hyaluronan and to other ligands. Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid (PubMed:11829748). At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+). Has cADPR hydrolase activity. Functions also as a receptor that binds the ligand CD31 on endothelial cells, promoting lymphocyte activation, proliferation, and migration across the endothelial barrier. Involved in the regulation of crucial dendritic cell functions acquired at the mature stage, such as CCL21-driven migration, survival, and Th1-polarizing activity. In lamina propria T lymphocytes, CD38/CD31 cognate interactions initiate a multistep signaling pathway resulting in activation of LCK anf LAT, followed by cytokine release., [UniProtKB, PubMed, UniProtKB]; The tetrameric interaction underlies the multifaceted actions of CD38., [RefSeq, PubMed]; This gene encodes a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Knockout mice deficient for this gene display altered humoral immune responses. In addition, knockout mice exhibit higher locomotor activity and defects in nurturing and social behaviors. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BFY8", "ec_number_list": "3.2.2.5;2.4.2.31;3.2.2.6;2.4.99.20;3.2.2.-", "go_molecular_function": "GO:0042802 identical protein binding;GO:0016740 transferase activity;GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0016849 phosphorus-oxygen lyase activity;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008284 positive regulation of cell population proliferation;GO:0030307 positive regulation of cell growth;GO:0032024 positive regulation of insulin secretion;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P56528-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60334-1", "uniprot_id": "CDO1_MOUSE", "mass": 23026.0, "length": 200, "protein_name": "Cysteine dioxygenase type 1", "gene_name": "Cdo1", "organism": "Mouse", "refseq_name": "cysteine dioxygenase type 1", "refseq_ac": "NP_149026", "gene_names_uniprotkb": "Cdo1", "gene_names_refseq": "1300002L19Rik; Cdo1; Cdo; D18Ucla3", "protein_names_uniprotkb": "Cysteine dioxygenase type 1; 1.13.11.20; CDO-I; CDO; Cysteine dioxygenase type I", "protein_names_refseq": "CDO-I; cysteine dioxygenase type 1; cysteine dioxygenase type I", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:12583); (R-MMU-1614558)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11602353;16492780;21750661;34428180;38110408;38428825", "class_list": "", "function": "Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Deletion of hepatocyte cysteine dioxygenase type 1, a bile acid repressed gene, enhances glutathione synthesis and ameliorates acetaminophen hepatotoxicity., [RefSeq, PubMed]; Rate-limiting enzyme of the cysteine catabolic process to taurine, which catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UED8", "ec_number_list": "2.7.10.2;2.7.11.24;1.13.11.20;3.6.5.2;2.7.12.2", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008198 ferrous iron binding;GO:0016151 nickel cation binding;GO:0017172 cysteine dioxygenase activity;GO:0005506 iron ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0045471 response to ethanol;GO:0051384 response to glucocorticoid;GO:0007595 lactation;GO:0051591 response to cAMP;GO:0043200 response to amino acid", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P60334-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61451-1", "uniprot_id": "CD53_MOUSE", "mass": 24164.0, "length": 219, "protein_name": "Leukocyte surface antigen CD53", "gene_name": "Cd53", "organism": "Mouse", "refseq_name": "leukocyte surface antigen CD53", "refseq_ac": "NP_031677", "gene_names_uniprotkb": "Cd53", "gene_names_refseq": "Cd53; Ox-44; Tspan25", "protein_names_uniprotkb": "Leukocyte surface antigen CD53; Cell surface glycoprotein CD53", "protein_names_refseq": "cell surface glycoprotein CD53; leukocyte surface antigen CD53", "tax_id": 10090, "disease": "", "pathway": " (mmu:12508); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "22847234;25605945;26740625;30084848;31748347;32428859;32532837;34514627;35767951;36542833;36581203;38363205;8452817", "class_list": "", "function": "Cutting Edge: The Tetraspanin CD53 Promotes CXCR4 Signaling and Bone Marrow Homing in B Cells., [RefSeq, PubMed]; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling (PubMed:36581203). Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (PubMed:32428859, PubMed:32532837). Plays a role in the activation of monocytes and B-cells (By similarity). Acts as an essential regulator of B-cell development by promoting interleukin-7 receptor/IL7R signaling (PubMed:31748347). Also promotes, in B-cells, the BCR signaling by recruiting PKC to the plasma membrane in order to phosphorylate its substrates (By similarity). Plays an essential role in lymphocyte homing to lymph nodes by stabilizing L-selectin/SELL cell surface expression (PubMed:32428859). Also mediates metabolic and inflammatory functions in hepatocytes and adipose tissue by promoting TNF and LPS signaling independent of the immune compartment (PubMed:36581203). Protects hematopoietic stem cell function in response to stress by facilitating DREAM complex activity through association with p130/RBL2 and its phosphatase PP2A (PubMed:36542833)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Tetraspanin CD53 controls T cell immunity through regulation of CD45RO stability, mobility, and function., [RefSeq, PubMed]; Tetraspanin CD53 modulates lymphocyte trafficking but not systemic autoimmunity in Lyn-deficient mice., [RefSeq, PubMed]; The tetraspanin transmembrane protein CD53 mediates dyslipidemia and integrates inflammatory and metabolic signaling in hepatocytes., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q61721", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface;GO:0001772 immunological synapse", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:1901741 positive regulation of myoblast fusion;GO:0043113 receptor clustering", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q61451-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63994-1", "uniprot_id": "CD33_MOUSE", "mass": 44824.0, "length": 403, "protein_name": "Myeloid cell surface antigen CD33", "gene_name": "Cd33", "organism": "Mouse", "refseq_name": "myeloid cell surface antigen CD33 isoform 1 precursor", "refseq_ac": "NP_001104528", "gene_names_uniprotkb": "Cd33; Siglec3", "gene_names_refseq": "Cd33; Siglec-3; gp67", "protein_names_uniprotkb": "Myeloid cell surface antigen CD33; Sialic acid-binding Ig-like lectin 3; Siglec-3", "protein_names_refseq": "CD33 antigen; myeloid cell surface antigen CD33 isoform 1 precursor; myeloid cell surface antigen CD33; sialic acid-binding Ig-like lectin 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:12489)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12773563;17008544;21750661;32803224;34428180;36639554;8193354", "class_list": "glycogene", "function": "CD33/TREM2 Signaling Mediates Sleep Deprivation-Induced Memory Impairment by Regulating Microglial Phagocytosis., [RefSeq, PubMed]; Gene therapy for Alzheimer's disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation., [RefSeq, PubMed]; MCD33 is expressed on myeloid precursors in the bone marrow, [RefSeq, PubMed]; SOCS3 inhibited the CD33-induced block on cytokine-induced proliferation. SOCS3 and its target protein CD33 are degraded concomitantly concomitantly., [RefSeq, PubMed]; Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (By similarity). Preferentially binds sialic acid to the short O-linked glycans of certain mucins (PubMed:12773563)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 44, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2RT59;Q63997", "ec_number_list": "", "go_molecular_function": "GO:0033691 sialic acid binding;GO:0019903 protein phosphatase binding;GO:0008160 protein tyrosine phosphatase activator activity;GO:0048029 monosaccharide binding", "go_cellular_component": "GO:0005777 peroxisome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007155 cell adhesion;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63994-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGC1-1", "uniprot_id": "CE022_MOUSE", "mass": 49430.0, "length": 442, "protein_name": "UPF0489 protein C5orf22 homolog", "gene_name": "6030458C11Rik", "organism": "Mouse", "refseq_name": "UPF0489 protein C5orf22 homolog isoform a", "refseq_ac": "NP_001159832", "gene_names_uniprotkb": "6030458C11Rik", "gene_names_refseq": "6030458C11Rik", "protein_names_uniprotkb": "UPF0489 protein C5orf22 homolog", "protein_names_refseq": "UPF0489 protein C5orf22 homolog isoform a; UPF0489 protein C5orf22 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:77877)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;30084848;31599954;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQ49;Q8BYV3;Q8BZ46;Q9CX64", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BGC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGN2-1", "uniprot_id": "CD033_MOUSE", "mass": 22460.0, "length": 192, "protein_name": "UPF0462 protein C4orf33 homolog", "gene_name": "D3Ertd751e", "organism": "Mouse", "refseq_name": "UPF0462 protein C4orf33 homolog isoform a", "refseq_ac": "NP_001093255", "gene_names_uniprotkb": "D3Ertd751e", "gene_names_refseq": "2810009O15Rik; 4930415G15Rik; D3Ertd751e", "protein_names_uniprotkb": "UPF0462 protein C4orf33 homolog", "protein_names_refseq": "UPF0462 protein C4orf33 homolog isoform a; UPF0462 protein C4orf33 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:73852)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C8S9;Q9CZE4;Q9D5M7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BGN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C9M2-1", "uniprot_id": "CCD15_MOUSE", "mass": 93527.0, "length": 810, "protein_name": "Coiled-coil domain-containing protein 15", "gene_name": "Ccdc15", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 15", "refseq_ac": "NP_001074898", "gene_names_uniprotkb": "Ccdc15", "gene_names_refseq": "A630039F14Rik; Ccdc15; D030074L19", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 15", "protein_names_refseq": "coiled-coil domain-containing protein 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:245902)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Plays an important role in primary cilium assembly, maintenance, and length regulation. Interacts with centriole inner scaffold proteins to promote proper centriole size and integrity and assembly of functional cilia. Required for the recruitment of both the inner scaffold protein POC1B and the distal SFI1/CETN2 complex to centrioles., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQB1;Q8BRD7;Q8CBK5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005814 centriole;GO:0034451 centriolar satellite", "go_biological_process": "GO:0060271 cilium assembly;GO:1903724 positive regulation of centriole elongation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C9M2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CC36-1", "uniprot_id": "CDNF_MOUSE", "mass": 21032.0, "length": 187, "protein_name": "Cerebral dopamine neurotrophic factor", "gene_name": "Cdnf", "organism": "Mouse", "refseq_name": "cerebral dopamine neurotrophic factor precursor", "refseq_ac": "NP_808315", "gene_names_uniprotkb": "Cdnf; Armetl1", "gene_names_refseq": "9330140G23; Armetl1; Cdnf", "protein_names_uniprotkb": "Cerebral dopamine neurotrophic factor; ARMET-like protein 1; Conserved dopamine neurotrophic factor", "protein_names_refseq": "ARMET-like protein 1; arginine-rich, mutated in early stage tumors-like 1; cerebral dopamine neurotrophic factor precursor; conserved dopamine neurotrophic factor", "tax_id": 10090, "disease": "bacterial infectious disease (Disease Ontology:DOID:104); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:227526)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17611540;25944479;26820513;31783118;35583716;36012764;36807563;37592005", "class_list": "", "function": "Beneficial behavioral effects of chronic cerebral dopamine neurotrophic factor (CDNF) infusion in the N171-82Q transgenic model of Huntington's disease. Publication Status: Online-Only, [RefSeq, PubMed]; CDNF (Armetl1) is expressed in several tissues, including the mouse embryonic and postnatal brain, [RefSeq, PubMed]; CDNF Interacts with ER Chaperones and Requires UPR Sensors to Promote Neuronal Survival. Publication Status: Online-Only, [RefSeq, PubMed]; Cerebral dopamine neurotrophic factor-deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice., [RefSeq, PubMed]; Secretion of mouse MANF and mouse CDNF is fundamentally regulated in the same manner, the variation of four C-terminal amino acids in the MANF and CDNF among species might influence their intracellular functions. Publication Status: Online-Only, [RefSeq, PubMed]; Sex and age differences in mice models of effort-based decision-making and anergia in depression: the role of dopamine, and cerebral-dopamine-neurotrophic-factor., [RefSeq, PubMed]; The Unconventional Growth Factors Cerebral Dopamine Neurotrophic Factor and Mesencephalic Astrocyte-Derived Neurotrophic Factor Promote Post-ischemic Neurological Recovery, Perilesional Brain Remodeling, and Lesion-Remote Axonal Plasticity., [RefSeq, PubMed]; This study demonstrated that decrease in mRNA level of CDNF in brain in microgravity., [RefSeq, PubMed]; Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0031175 neuron projection development;GO:0032502 developmental process;GO:0071542 dopaminergic neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CC36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CE13-1", "uniprot_id": "CCD17_MOUSE", "mass": 62536.0, "length": 565, "protein_name": "Coiled-coil domain-containing protein 17", "gene_name": "Ccdc17", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 17", "refseq_ac": "NP_001033005", "gene_names_uniprotkb": "Ccdc17", "gene_names_refseq": "1100001F07Rik; Ccdc17", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 17", "protein_names_refseq": "coiled-coil domain-containing protein 17", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861)", "pathway": " (mmu:622665)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0QZT6;Q8BTE7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0005930 axoneme", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CE13-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CEQ0-1", "uniprot_id": "CDKL1_MOUSE", "mass": 41024.0, "length": 352, "protein_name": "Cyclin-dependent kinase-like 1", "gene_name": "Cdkl1", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase-like 1", "refseq_ac": "NP_899117", "gene_names_uniprotkb": "Cdkl1", "gene_names_refseq": "4933411O17Rik; Cdkl1", "protein_names_uniprotkb": "Cyclin-dependent kinase-like 1; 2.7.11.22", "protein_names_refseq": "cyclin dependent kinase like 1 (CDC2 related kinase); cyclin-dependent kinase-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71091)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30084848", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005814 centriole;GO:0097225 sperm midpiece", "go_biological_process": "GO:0007507 heart development;GO:1902017 regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CEQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QZR8-1", "uniprot_id": "CCNQ_MOUSE", "mass": 28928.0, "length": 250, "protein_name": "Cyclin-Q", "gene_name": "Ccnq", "organism": "Mouse", "refseq_name": "cyclin-Q", "refseq_ac": "NP_932106", "gene_names_uniprotkb": "Ccnq; Fam58a; Fam58b", "gene_names_refseq": "1810009O10Rik; Ccnq; Fam58a; Fam58b", "protein_names_uniprotkb": "Cyclin-Q; CDK10-activating cyclin; Cyclin-M; Cyclin-related protein FAM58A; Cyclin-related protein FAM58B", "protein_names_refseq": "CDK10-activating cyclin; cyclin M; cyclin-Q; cyclin-related protein FAM58A; cyclin-related protein FAM58B; family with sequence similarity 58, member B", "tax_id": 10090, "disease": "syndactyly-telecanthus-anogenital and renal malformations syndrome (Disease Ontology:DOID:0111931)", "pathway": " (mmu:69109)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Activating cyclin for the cyclin-associated kinase CDK10., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030295 protein kinase activator activity;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0043410 positive regulation of MAPK cascade;GO:1902749 regulation of cell cycle G2/M phase transition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8QZR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCN6-1", "uniprot_id": "CD99_MOUSE", "mass": 16783.0, "length": 175, "protein_name": "CD99 antigen", "gene_name": "Cd99", "organism": "Mouse", "refseq_name": "CD99 antigen precursor", "refseq_ac": "NP_079860", "gene_names_uniprotkb": "Cd99; Pilrl", "gene_names_refseq": "1110061M03Rik; 2410026K10Rik; Cd99; D4; Pilr-l; pilr-1", "protein_names_uniprotkb": "CD99 antigen; PILR-L; Paired immunoglobin-like type 2 receptor-ligand", "protein_names_refseq": "CD99 antigen precursor; paired immunoglobin-like type 2 receptor-ligand", "tax_id": 10090, "disease": "", "pathway": " (mmu:673094)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14970179;15280198;15978751;20479283;24133166;26101266;28223280;31385804;38750588", "class_list": "", "function": "Endothelial CD99 promotes leukocyte attachment to endothelium in inflamed vessels by a heterophilic ligand. In addition, CD99 binds to PILRs on neutrophils, an interaction that leads to increased shear resistance of the neutrophil attachment to ICAM-1., [RefSeq, PubMed]; Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration., [RefSeq, PubMed]; Involved in T-cell adhesion processes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1., [UniProtKB, PubMed, PubMed]; Role in membrane trafficking of CD99L2 and in controlling transendothelial migration of leukocytes, [RefSeq, PubMed]; Sex- and species-specific contribution of CD99 to T cell costimulation during multiple sclerosis. Publication Status: Online-Only, [RefSeq, PubMed]; Upon neutrophil arrest, binding of PILR-beta1 to CD99 ceases, shifting the signaling balance towards inhibitory PILR-alpha. This enables integrin deactivation and supports cell diapedesis in venules of the mouse cremaster muscle. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4L299;Q4L2A4;Q8BLN1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:2000391 positive regulation of neutrophil extravasation;GO:0001773 myeloid dendritic cell activation;GO:0072683 T cell extravasation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VCN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D024-1", "uniprot_id": "CCD47_MOUSE", "mass": 55844.0, "length": 483, "protein_name": "PAT complex subunit CCDC47", "gene_name": "Ccdc47", "organism": "Mouse", "refseq_name": "PAT complex subunit CCDC47 precursor", "refseq_ac": "NP_080285", "gene_names_uniprotkb": "Ccdc47; Asp4", "gene_names_refseq": "2610204L23Rik; Ccdc47; asp4; calumin", "protein_names_uniprotkb": "PAT complex subunit CCDC47; Adipocyte-specific protein 4; Calumin; Coiled-coil domain-containing protein 47", "protein_names_refseq": "PAT complex subunit CCDC47 precursor; PAT complex subunit CCDC47; adipocyte-specific protein 4; coiled-coil domain-containing protein 47", "tax_id": 10090, "disease": "", "pathway": " (mmu:67163)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17204322;21750661;22197811;25009997;34428180;37507081", "class_list": "", "function": "Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (By similarity). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein (By similarity). Within the PAT subcomplex, CCDC47 occludes the lateral gate of the SEC61 complex (By similarity). Involved in the regulation of calcium ion homeostasis in the ER (By similarity). Required for proper protein degradation via the ERAD (ER-associated degradation) pathway (By similarity). Has an essential role in the maintenance of ER organization during embryogenesis (PubMed:25009997)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Observations suggest that calumin plays an essential role in ER Ca2+ handling and is also implicated in signaling from the ER, which is closely associated with cell-fate decision, [RefSeq, PubMed]; These findings suggested that calumin serves to maintain the yolk sac integrity through participation in the ERAD activity, contributing to embryonic development., [RefSeq, PubMed]; These results reveal a novel mechanism for the regulation of Ca(2+) release-activated Ca(2+) channels by calumin., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AR94;Q3TSB5;Q3V1S7;Q8C5D9;Q920S6", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0043022 ribosome binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005791 rough endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0030867 rough endoplasmic reticulum membrane;GO:0101031 protein folding chaperone complex", "go_biological_process": "GO:0045048 protein insertion into ER membrane;GO:0009791 post-embryonic development;GO:0036503 ERAD pathway;GO:0055074 calcium ion homeostasis;GO:0006983 ER overload response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D024-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DA64-1", "uniprot_id": "CDRT4_MOUSE", "mass": 20473.0, "length": 179, "protein_name": "CMT1A duplicated region transcript 4 protein homolog", "gene_name": "Cdrt4", "organism": "Mouse", "refseq_name": "CMT1A duplicated region transcript 4 protein homolog", "refseq_ac": "NP_079772", "gene_names_uniprotkb": "Cdrt4", "gene_names_refseq": "1700019I23Rik; Cdrt4", "protein_names_uniprotkb": "CMT1A duplicated region transcript 4 protein homolog", "protein_names_refseq": "CMT1A duplicated region transcript 4 protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66338)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9Y3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9DA64-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JMG2-1", "uniprot_id": "C1GLC_MOUSE", "mass": 36067.0, "length": 316, "protein_name": "C1GALT1-specific chaperone 1", "gene_name": "C1galt1c1", "organism": "Mouse", "refseq_name": "C1GALT1-specific chaperone 1", "refseq_ac": "NP_067525", "gene_names_uniprotkb": "C1galt1c1; Cosmc", "gene_names_refseq": "1500002I11Rik; C1GalT2; C1galt1c1; Cosmc", "protein_names_uniprotkb": "C1GALT1-specific chaperone 1; C1Gal-T2; C1GalT2; Core 1 beta1,3-galactosyltransferase 2; Core 1 beta3-Gal-T2; Core 1 beta3-galactosyltransferase-specific molecular chaperone; mC1Gal-T2", "protein_names_refseq": "C1GALT1-specific chaperone 1; C1Gal-T2; beta1,3-galactosyltransferase 2; core 1 beta1,3-galactosyltransferase 2; core 1 beta3-Gal-T2; core 1 beta3-galactosyltransferase-specific molecular chaperone; mC1Gal-T2", "tax_id": 10090, "disease": "Tn polyagglutination syndrome (Disease Ontology:DOID:0080520); hemolytic-uremic syndrome (Disease Ontology:DOID:12554)", "pathway": " (mmu:59048); (R-MMU-913709)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10679242;12464682;17038624;20173027;20439703;30084848;34203471;34428180;35163200", "class_list": "glycogene;glycosyltransferase", "function": "A somatic mutation in the chaperone gene Cosmc abolished function of a glycosyltransferase, disrupting O-glycan Core 1 synthesis & creating a tumor-specific glycopeptidic neo-epitope consisting of a monosaccharide and a specific wild-type protein sequence, [RefSeq, PubMed]; Cosmc is an essential chaperone for correct protein O-glycosylation., [RefSeq, PubMed]; Global Loss of Core 1-Derived O-Glycans in Mice Leads to High Mortality Due to Acute Kidney Failure and Gastric Ulcers. Publication Status: Online-Only, [RefSeq, PubMed]; Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0030168 platelet activation;GO:0036344 platelet morphogenesis", "synthesized_glycan_count": 3300, "hit_score": 1.0, "record_id": "Q9JMG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIX8-1", "uniprot_id": "LGSN_MOUSE", "mass": 62164.0, "length": 563, "protein_name": "Lengsin", "gene_name": "Lgsn", "organism": "Mouse", "refseq_name": "lengsin", "refseq_ac": "NP_705829", "gene_names_uniprotkb": "Lgsn; Gluld1; Lgs", "gene_names_refseq": "Gluld1; Lgsn; Lgs; lengsin", "protein_names_uniprotkb": "Lengsin; Glutamate-ammonia ligase domain-containing protein 1; Lens glutamine synthase-like", "protein_names_refseq": "glutamate-ammonia ligase (glutamine synthase) domain containing 1; glutamate-ammonia ligase (glutamine synthetase) domain containing 1; glutamate-ammonia ligase domain-containing protein 1; lengsin", "tax_id": 10090, "disease": "", "pathway": " (mmu:266744)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17161372;18178558;20107048;21750661", "class_list": "", "function": "Lengsin may act as a component of the cytoskeleton itself or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. GeneRIF: Lengsin interacts with intermediate filament proteins of the eye lens and is associated with terminal differentiation of fiber cells, [RefSeq, PubMed]; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity., [UniProtKB, PubMed]; These results indicate that the ZNRF1-GS system may play an important role in correlating Schwann cell metabolism with its differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q149K1", "ec_number_list": "", "go_molecular_function": "GO:0003824 catalytic activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CIX8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01845-1", "uniprot_id": "LAC3_MOUSE", "mass": 11371.0, "length": 104, "protein_name": "Ig lambda-3 chain C region", "gene_name": "Iglc3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Iglc3", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig lambda-3 chain C region", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-198933); (R-MMU-202733); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-2168880); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-5690714); (R-MMU-977606); (R-MMU-983695)", "pathway_count": 15, "publication_count": 4, "publication_id_list": "21750661;34428180;6165998;6812053", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0071735 IgG immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P01845-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U4E0-1", "uniprot_id": "LHPL4_MOUSE", "mass": 27050.0, "length": 247, "protein_name": "LHFPL tetraspan subfamily member 4 protein", "gene_name": "Lhfpl4", "organism": "Mouse", "refseq_name": "LHFPL tetraspan subfamily member 4 protein", "refseq_ac": "NP_808431", "gene_names_uniprotkb": "Lhfpl4; Garlh4; Kiaa4027; Lh4", "gene_names_refseq": "1190004M23Rik; B230384L07; Lhfpl4; mKIAA4027", "protein_names_uniprotkb": "LHFPL tetraspan subfamily member 4 protein; GABAA receptor regulatory Lhfpl4; Lipoma HMGIC fusion partner-like 4 protein", "protein_names_refseq": "GABAA receptor regulatory Lhfpl4; LHFPL tetraspan subfamily member 4 protein; lipoma HMGIC fusion partner-like 4 protein", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 67 (Disease Ontology:DOID:0110518)", "pathway": " (mmu:269788)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;26964900;28279354;28978485;29742426;40885482", "class_list": "", "function": "Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma-aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites (PubMed:28279354, PubMed:28978485, PubMed:29742426). Acts in concert with NLGN2 to recruit or stabilize GABAARs (PubMed:29742426)., [UniProtKB, PubMed, PubMed, PubMed]; The essential role of LHFPL4/GARLH4 in brain functions by regulating inhibitory synapse formation as a major NL2 binding partner, is reported., [RefSeq, PubMed]; The results establish LHFPL4 as a synapse-specific tetraspanin essential for inhibitory synapse function and provide fresh insights into the molecular make-up of inhibitory synapses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTS1;Q8BQU2", "ec_number_list": "", "go_molecular_function": "GO:0050811 GABA receptor binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045211 postsynaptic membrane;GO:0060077 inhibitory synapse", "go_biological_process": "GO:0097112 gamma-aminobutyric acid receptor clustering;GO:0007399 nervous system development;GO:0007605 sensory perception of sound;GO:1905702 regulation of inhibitory synapse assembly;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q5U4E0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q149C3-1", "uniprot_id": "LIGO4_MOUSE", "mass": 64189.0, "length": 593, "protein_name": "Leucine-rich repeat and immunoglobulin-like domain containing-NOGO receptor-interacting protein 4", "gene_name": "Lingo4", "organism": "Mouse", "refseq_name": "leucine-rich repeat and immunoglobulin-like domain containing-NOGO receptor-interacting protein 4 precursor", "refseq_ac": "NP_001355582", "gene_names_uniprotkb": "Lingo4; Lrrn6d", "gene_names_refseq": "A530050P17Rik; LERN4; Lingo4; Lrrn6d", "protein_names_uniprotkb": "Leucine-rich repeat and immunoglobulin-like domain containing-NOGO receptor-interacting protein 4; Leucine-rich repeat neuronal protein 6D", "protein_names_refseq": "leucine rich repeat neuronal 6D; leucine-rich repeat and immunoglobulin-like domain containing-NOGO receptor-interacting protein 4 precursor; leucine-rich repeat and immunoglobulin-like domain containing-NOGO receptor-interacting protein 4; leucine-rich repeat neuronal protein 6D", "tax_id": 10090, "disease": "", "pathway": " (mmu:320747)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A0A4X2", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0051960 regulation of nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q149C3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88951-1", "uniprot_id": "LIN7B_MOUSE", "mass": 22914.0, "length": 207, "protein_name": "Protein lin-7 homolog B", "gene_name": "Lin7b", "organism": "Mouse", "refseq_name": "protein lin-7 homolog B", "refseq_ac": "NP_035828", "gene_names_uniprotkb": "Lin7b; Mals2; Veli2", "gene_names_refseq": "LIN-7B; Lin7b; MALS-2; Veli2", "protein_names_uniprotkb": "Protein lin-7 homolog B; Lin-7B; MALS-2; Mammalian lin-seven protein 2; Veli-2; Vertebrate lin-7 homolog 2", "protein_names_refseq": "lin 7 homolog b; lin-7 homolog B; mammalian lin-seven protein 2; protein lin-7 homolog B; veli-2; vertebrate homolog of C. elegans Lin-7 type 2; vertebrate lin-7 homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:22342); (R-MMU-212676); (R-MMU-5666185)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10341223;10846156;11742811;15317815;15494546;15863617;20720508;21750661;22102253;22337881;9753324", "class_list": "", "function": "Analysis of structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins, [RefSeq, PubMed]; Crystals of tripartite complex 1 of L27(PATJ)-(L27N,L27C)(Pals1)-L27(MALS) diffracted to 2.05 A resolution, [RefSeq, PubMed]; Data suggest that decreased cortical LIN7b expression may contribute to abnormal corticostriatal connectivity in Huntington disease., [RefSeq, PubMed]; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (PubMed:10846156). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface., [UniProtKB, PubMed, PubMed]; The crystal structure of a 4-L27 domain-containing heterotrimer derived from the tripartite complex Patj/Pals1/Mals2, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0015031 protein transport;GO:0007269 neurotransmitter secretion;GO:0006887 exocytosis;GO:0048489 synaptic vesicle transport;GO:0008582 regulation of synaptic assembly at neuromuscular junction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O88951-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CD94-1", "uniprot_id": "LIN52_MOUSE", "mass": 12498.0, "length": 112, "protein_name": "Protein lin-52 homolog", "gene_name": "Lin52", "organism": "Mouse", "refseq_name": "protein lin-52 homolog isoform 1", "refseq_ac": "NP_001392263", "gene_names_uniprotkb": "Lin52", "gene_names_refseq": "5830457H20Rik; Lin52", "protein_names_uniprotkb": "Protein lin-52 homolog", "protein_names_refseq": "protein lin-52 homolog isoform 1; protein lin-52 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:217708); (R-MMU-1538133)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8Q0Q6C4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0070176 DRM complex", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CD94-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A5X4-1", "uniprot_id": "KR291_MOUSE", "mass": 35045.0, "length": 342, "protein_name": "Keratin-associated protein 29-1", "gene_name": "Krtap29-1", "organism": "Mouse", "refseq_name": "keratin-associated protein 29-1", "refseq_ac": "NP_001365439", "gene_names_uniprotkb": "Krtap29-1; Gm14195; Kap29.2", "gene_names_refseq": "Gm14195; Krtap29-1", "protein_names_uniprotkb": "Keratin-associated protein 29-1; Keratin-associated protein 29.2", "protein_names_refseq": "Putative keratin-associated protein 29-1; keratin-associated protein 29-1; keratin-associated protein 29.2", "tax_id": 10090, "disease": "", "pathway": " (mmu:100462664); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2A5X4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A5X5-1", "uniprot_id": "KR161_MOUSE", "mass": 52020.0, "length": 502, "protein_name": "Keratin-associated protein 16-1", "gene_name": "Krtap16-1", "organism": "Mouse", "refseq_name": "keratin-associated protein 16-1", "refseq_ac": "NP_001242986", "gene_names_uniprotkb": "Krtap16-1; Gm11570", "gene_names_refseq": "Gm11570; Krtap16-1", "protein_names_uniprotkb": "Keratin-associated protein 16-1", "protein_names_refseq": "keratin-associated protein 16-1; putative keratin-associated protein 10-like ENSP00000375147 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:100504183); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2A5X5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A3KMN5-1", "uniprot_id": "LARGN_MOUSE", "mass": 32836.0, "length": 304, "protein_name": "Protein Largen", "gene_name": "Prr16", "organism": "Mouse", "refseq_name": "protein Largen", "refseq_ac": "NP_001074693", "gene_names_uniprotkb": "Prr16", "gene_names_refseq": "5430406M13Rik; Prr16", "protein_names_uniprotkb": "Protein Largen; Proline-rich protein 16", "protein_names_refseq": "proline-rich protein 16; protein Largen", "tax_id": 10090, "disease": "", "pathway": " (mmu:71373)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24656129", "class_list": "", "function": "Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration (Probable)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLB9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0045727 positive regulation of translation;GO:0045793 positive regulation of cell size", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A3KMN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BIG2-1", "uniprot_id": "LKAM1_MOUSE", "mass": 22126.0, "length": 198, "protein_name": "Protein LKAAEAR1", "gene_name": "Lkaaear1", "organism": "Mouse", "refseq_name": "protein LKAAEAR1 isoform 2", "refseq_ac": "NP_950188", "gene_names_uniprotkb": "Lkaaear1; 4930526D03Rik", "gene_names_refseq": "4930526D03Rik; Gm692; Lkaaear1", "protein_names_uniprotkb": "Protein LKAAEAR1; LKAAEAR motif-containing protein 1", "protein_names_refseq": "LKAAEAR motif-containing protein 1; protein LKAAEAR1 isoform 2; protein LKAAEAR1", "tax_id": 10090, "disease": "", "pathway": " (mmu:277496)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5I0W3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BIG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q925H2-1", "uniprot_id": "KR191_MOUSE", "mass": 8850.0, "length": 87, "protein_name": "Keratin-associated protein 19-1", "gene_name": "Krtap19-1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Krtap19-1; Krtap16-2; Krtap16-9; Krtap16.9", "gene_names_refseq": "", "protein_names_uniprotkb": "Keratin-associated protein 19-1; Keratin-associated protein 16-9; Keratin-associated protein 16.9", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:170657); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11290294;15385554;17151017;21750661", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q925H2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61092-1", "uniprot_id": "LAMC2_MOUSE", "mass": 130161.0, "length": 1191, "protein_name": "Laminin subunit gamma-2", "gene_name": "Lamc2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Lamc2", "gene_names_refseq": "", "protein_names_uniprotkb": "Laminin subunit gamma-2; Epiligrin subunit gamma; Kalinin subunit gamma; Kalinin/nicein/epiligrin 100 kDa subunit; Laminin B2t chain; Laminin-5 subunit gamma; Nicein subunit gamma", "protein_names_refseq": "", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); junctional epidermolysis bullosa Herlitz type (Disease Ontology:DOID:0060737); junctional epidermolysis bullosa non-Herlitz type (Disease Ontology:DOID:0060738); junctional epidermolysis bullosa (Disease Ontology:DOID:3209); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung small cell carcinoma (Disease Ontology:DOID:5409)", "pathway": " (mmu:16782)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;11733994;21750661;40885482;7882992", "class_list": "", "function": "Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 7, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005938 cell cortex;GO:0031012 extracellular matrix;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0009887 animal organ morphogenesis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q61092-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08640-1", "uniprot_id": "KRA14_MOUSE", "mass": 17919.0, "length": 167, "protein_name": "Keratin-associated protein 14", "gene_name": "Krtap14", "organism": "Mouse", "refseq_name": "keratin-associated protein 14", "refseq_ac": "NP_038735", "gene_names_uniprotkb": "Krtap14; Pmg1", "gene_names_refseq": "Krtap14; Pmg1; mKAP13", "protein_names_uniprotkb": "Keratin-associated protein 14; Anagen-specific protein KAP13; Pubertal mammary gland-specific protein 1; mKAP13", "protein_names_refseq": "anagen-specific protein KAP13; keratin-associated protein 14; pubertal mammary gland-specific protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:23927)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10446281;15385554;9287118;9804342", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]; Krtap16 is a hair keratin-associated protein gene complex regulated by Hoxc13; localized to chromosome 16, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35148", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O08640-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01843-1", "uniprot_id": "LAC1_MOUSE", "mass": 11575.0, "length": 105, "protein_name": "Ig lambda-1 chain C region", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig lambda-1 chain C region", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "29187734;5276767;6259534;6283385;6812053", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071735 IgG immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P01843-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01844-1", "uniprot_id": "LAC2_MOUSE", "mass": 11255.0, "length": 104, "protein_name": "Ig lambda-2 chain C region", "gene_name": "Iglc2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Iglc2", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig lambda-2 chain C region", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-198933); (R-MMU-202733); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-2168880); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-5690714); (R-MMU-977606); (R-MMU-983695)", "pathway_count": 15, "publication_count": 6, "publication_id_list": "21750661;4760498;6165998;6283385;6287422;6812053", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0071735 IgG immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P01844-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24527-1", "uniprot_id": "LKHA4_MOUSE", "mass": 69051.0, "length": 611, "protein_name": "Leukotriene A-4 hydrolase", "gene_name": "Lta4h", "organism": "Mouse", "refseq_name": "leukotriene A-4 hydrolase isoform 2", "refseq_ac": "NP_001300826", "gene_names_uniprotkb": "Lta4h", "gene_names_refseq": "Lta4h", "protein_names_uniprotkb": "Leukotriene A-4 hydrolase; 3.3.2.6; 3.4.11.4; LTA-4 hydrolase; Leukotriene A(4) hydrolase; Tripeptide aminopeptidase LTA4H", "protein_names_refseq": "LTA-4 hydrolase; LTA4 hydrodase; leukotriene A-4 hydrolase isoform 2; leukotriene A-4 hydrolase; tripeptide aminopeptidase LTA4H", "tax_id": 10090, "disease": "squamous cell carcinoma (Disease Ontology:DOID:1749); asthma (Disease Ontology:DOID:2841); adenocarcinoma (Disease Ontology:DOID:299)", "pathway": " (mmu:16993); (R-MMU-2142691); (R-MMU-6798695); (R-MMU-9018676); (R-MMU-9018681); (R-MMU-9018896); (R-MMU-9020265); (R-MMU-9023661)", "pathway_count": 8, "publication_count": 12, "publication_id_list": "10586081;1710117;1881903;20813919;25428506;31219806;34428180;37086004;37453647;37507081;37976357;9287304", "class_list": "", "function": "Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities (By similarity). Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4), as well as other lipid epoxides (PubMed:1881903, PubMed:9287304). Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (By similarity). In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Inhibition of Leukotriene A4 Hydrolase Suppressed Cartilage Degradation and Synovial Inflammation in a Mouse Model of Experimental Osteoarthritis., [RefSeq, PubMed]; Leukotriene A4 hydrolase inhibition improves age-related cognitive decline via modulation of synaptic function., [RefSeq, PubMed]; The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UY71;Q8VDR8", "ec_number_list": "2.4.1.25;3.2.1.33;3.5.4.6;1.11.1.24;3.4.22.52;3.4.19.12;3.4.24.34;3.4.22.27;1.1.1.42;3.4.21.46;4.1.2.13;5.3.1.9;5.1.3.-;3.4.21.4;3.6.4.10;3.4.21.-;3.2.1.17;1.16.3.1;3.6.5.-;4.2.1.24;3.4.22.1;3.2.1.31;2.7.1.11;5.2.1.8;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;3.1.3.48;5.3.2.1;5.3.3.12;3.4.24.35;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;3.1.6.12;2.7.10.2;2.7.11.1;2.7.1.40;3.5.4.5;3.4.25.1;2.7.4.6;2.7.13.3;3.6.4.6;2.7.1.1;2.7.1.-;3.1.1.47;3.6.4.13;2.7.11.22;2.7.11.23;2.3.2.26;5.4.2.2;5.4.2.7;2.3.2.27;3.1.6.14;1.8.3.2;3.4.19.1;3.6.1.6;2.3.3.8;4.1.2.4;2.3.2.5;3.2.1.14;5.4.2.11;5.4.2.4;2.4.1.1;3.5.1.3;2.4.1.186;3.4.18.1;3.5.1.23;3.5.1.-;3.4.19.9", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0004301 epoxide hydrolase activity;GO:0070006 metalloaminopeptidase activity;GO:0004463 leukotriene-A4 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0010043 response to zinc ion;GO:0043171 peptide catabolic process;GO:0006691 leukotriene metabolic process;GO:0019370 leukotriene biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P24527-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97400-1", "uniprot_id": "LEG10_MOUSE", "mass": 8037.0, "length": 68, "protein_name": "Galectin-10", "gene_name": "Clc", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Clc; Clcp", "gene_names_refseq": "", "protein_names_uniprotkb": "Galectin-10; CLC; Charcot-Leyden crystal protein homolog; Gal-10", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9119387", "class_list": "", "function": "Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0002667 regulation of T cell anergy;GO:0002724 regulation of T cell cytokine production;GO:0070231 T cell apoptotic process;GO:0046006 regulation of activated T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P97400-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VET5-1", "uniprot_id": "LMTD2_MOUSE", "mass": 73784.0, "length": 664, "protein_name": "Lamin tail domain-containing protein 2", "gene_name": "Lmntd2", "organism": "Mouse", "refseq_name": "lamin tail domain-containing protein 2 isoform 2", "refseq_ac": "NP_082326", "gene_names_uniprotkb": "Lmntd2", "gene_names_refseq": "1600016N20Rik; Lmntd2", "protein_names_uniprotkb": "Lamin tail domain-containing protein 2", "protein_names_refseq": "lamin tail domain-containing protein 2 isoform 2; lamin tail domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72000)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34887587;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CW10", "ec_number_list": "", "go_molecular_function": "GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005638 lamin filament", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q0VET5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TST5-1", "uniprot_id": "LAMP3_MOUSE", "mass": 45129.0, "length": 411, "protein_name": "Lysosome-associated membrane glycoprotein 3", "gene_name": "Lamp3", "organism": "Mouse", "refseq_name": "lysosome-associated membrane glycoprotein 3 precursor", "refseq_ac": "NP_796330", "gene_names_uniprotkb": "Lamp3", "gene_names_refseq": "1200002D17Rik; Cd208; DC-LAMP; DCLAMP; LAMP; Lamp3; TSC403", "protein_names_uniprotkb": "Lysosome-associated membrane glycoprotein 3; DC LAMP; DC-lysosome-associated membrane glycoprotein; LAMP-3; Lysosomal-associated membrane protein 3", "protein_names_refseq": "DC LAMP; DC-lysosome-associated membrane glycoprotein; LAMP-3; dendritic cells-lysosome associated membrane glycoprotein; lysosome-associated membrane glycoprotein 3 precursor; lysosome-associated membrane glycoprotein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:239739)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "30084848;35820727", "class_list": "", "function": "Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction. Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process. Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway. May also play a role in dendritic cell function and in adaptive immunity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1F6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0048471 perinuclear region of cytoplasm;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0072594 establishment of protein localization to organelle;GO:0006629 lipid metabolic process;GO:0010506 regulation of autophagy;GO:0010628 positive regulation of gene expression;GO:0043129 surfactant homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TST5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMN4-1", "uniprot_id": "LMLN_MOUSE", "mass": 76575.0, "length": 681, "protein_name": "Leishmanolysin-like peptidase", "gene_name": "Lmln", "organism": "Mouse", "refseq_name": "leishmanolysin-like peptidase precursor", "refseq_ac": "NP_766411", "gene_names_uniprotkb": "Lmln", "gene_names_refseq": "5330415H22Rik; Lmln", "protein_names_uniprotkb": "Leishmanolysin-like peptidase; 3.4.24.-", "protein_names_refseq": "leishmanolysin-like peptidase precursor; leishmanolysin-like peptidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:239833)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10.1101/2023.09.13.557529", "class_list": "", "function": "Metalloprotease., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BMN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C1I6-1", "uniprot_id": "KR163_MOUSE", "mass": 8433.0, "length": 86, "protein_name": "Keratin-associated protein 16-3", "gene_name": "Krtap16-3", "organism": "Mouse", "refseq_name": "keratin-associated protein 16-3", "refseq_ac": "NP_899119", "gene_names_uniprotkb": "Krtap16-3; Krtap16-10; Krtap16.3", "gene_names_refseq": "5430404J20Rik; Krtap16-10; Krtap16-3", "protein_names_uniprotkb": "Keratin-associated protein 16-3; Keratin-associated protein 16-10; Keratin-associated protein 16.3", "protein_names_refseq": "keratin-associated protein 16-3; keratin-associated protein 16.3", "tax_id": 10090, "disease": "", "pathway": " (mmu:71369); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11290294;15385554;17151017", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]; Krtap16 is a hair keratin-associated protein gene complex regulated by Hoxc13; localized to chromosome 16, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3B7Z5;Q925H8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C1I6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEE1-1", "uniprot_id": "LMCD1_MOUSE", "mass": 40996.0, "length": 365, "protein_name": "LIM and cysteine-rich domains protein 1", "gene_name": "Lmcd1", "organism": "Mouse", "refseq_name": "LIM and cysteine-rich domains protein 1", "refseq_ac": "NP_659048", "gene_names_uniprotkb": "Lmcd1", "gene_names_refseq": "Lmcd1; dyxin", "protein_names_uniprotkb": "LIM and cysteine-rich domains protein 1", "protein_names_refseq": "LIM and cysteine-rich domains protein 1", "tax_id": 10090, "disease": "coronary stenosis (Disease Ontology:DOID:4248)", "pathway": " (mmu:30937); (R-MMU-5683826)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;16199866;20026769;34428180;34968577;36210013;36288343;37311356;37507081;39927985", "class_list": "", "function": "Expression of LMCD1/dyxin is remarkably similar to that of GATA6, with high-level expression observed in distal airway epithelium of the lung, vascular smooth muscle, and myocardium., [RefSeq, PubMed]; LMCD1 is involved in tubulointerstitial inflammation in the early phase of renal fibrosis by promoting NFATc1-mediated NLRP3 activation., [RefSeq, PubMed]; Suppression of LMCD1 ameliorates renal fibrosis by blocking the activation of ERK pathway., [RefSeq, PubMed]; Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010611 regulation of cardiac muscle hypertrophy;GO:0070886 positive regulation of calcineurin-NFAT signaling cascade", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8VEE1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q925H4-1", "uniprot_id": "KR211_MOUSE", "mass": 12539.0, "length": 128, "protein_name": "Keratin-associated protein 21-1", "gene_name": "Krtap21-1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Krtap21-1; Krtap16-7; Krtap16.7", "gene_names_refseq": "", "protein_names_uniprotkb": "Keratin-associated protein 21-1; Keratin-associated protein 16-7; Keratin-associated protein 16.7", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "11290294;15385554;17151017", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1B6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "GO:0007165 signal transduction;GO:0008283 cell population proliferation;GO:0001942 hair follicle development;GO:0043588 skin development;GO:0048589 developmental growth", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q925H4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q925H7-1", "uniprot_id": "KR194_MOUSE", "mass": 8626.0, "length": 84, "protein_name": "Keratin-associated protein 19-4", "gene_name": "Krtap19-4", "organism": "Mouse", "refseq_name": "keratin-associated protein 19-4", "refseq_ac": "NP_570943", "gene_names_uniprotkb": "Krtap19-4; Krtap16-4; Krtap16.4", "gene_names_refseq": "Krtap16-4; Krtap19-4", "protein_names_uniprotkb": "Keratin-associated protein 19-4; Keratin-associated protein 16-4; Keratin-associated protein 16.4", "protein_names_refseq": "keratin-associated protein 16-4; keratin-associated protein 16.4; keratin-associated protein 19-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:170654); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11290294;15385554;17151017", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]; Krtap16 is a hair keratin-associated protein gene complex regulated by Hoxc13; localized to chromosome 16, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q925H7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q925I0-1", "uniprot_id": "KR192_MOUSE", "mass": 13738.0, "length": 141, "protein_name": "Keratin-associated protein 19-2", "gene_name": "Krtap19-2", "organism": "Mouse", "refseq_name": "keratin-associated protein 19-2", "refseq_ac": "NP_570940", "gene_names_uniprotkb": "Krtap19-2; Krtap16-1; Krtap16.1", "gene_names_refseq": "Krtap16-1; Krtap19-2", "protein_names_uniprotkb": "Keratin-associated protein 19-2; Keratin-associated protein 16-1; Keratin-associated protein 16.1", "protein_names_refseq": "keratin associated protein 16-1; keratin-associated protein 16.1; keratin-associated protein 19-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:170651); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11290294;15385554;17151017", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]; Krtap16 is a hair keratin-associated protein gene complex regulated by Hoxc13; localized to chromosome 16, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUY7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q925I0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWJ3-1", "uniprot_id": "KTBL1_MOUSE", "mass": 34035.0, "length": 299, "protein_name": "KATNB1-like protein 1", "gene_name": "Katnbl1", "organism": "Mouse", "refseq_name": "KATNB1-like protein 1", "refseq_ac": "NP_077216", "gene_names_uniprotkb": "Katnbl1", "gene_names_refseq": "2410042D21Rik; Katnbl1", "protein_names_uniprotkb": "KATNB1-like protein 1; Katanin p80 subunit B-like 1", "protein_names_refseq": "KATNB1-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72425)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "36210013", "class_list": "", "function": "Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7P7;Q8C7R6", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0008352 katanin complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0032154 cleavage furrow", "go_biological_process": "GO:0051495 positive regulation of cytoskeleton organization;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CWJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKU8-1", "uniprot_id": "LMX1A_MOUSE", "mass": 42857.0, "length": 382, "protein_name": "LIM homeobox transcription factor 1-alpha", "gene_name": "Lmx1a", "organism": "Mouse", "refseq_name": "LIM homeobox transcription factor 1-alpha", "refseq_ac": "NP_387501", "gene_names_uniprotkb": "Lmx1a", "gene_names_refseq": "Lmx1.1; Lmx1a; dreher; dr; sst", "protein_names_uniprotkb": "LIM homeobox transcription factor 1-alpha; LIM/homeobox protein 1.1; LIM/homeobox protein LMX1A; LMX-1.1", "protein_names_refseq": "LIM homeobox transcription factor 1-alpha; LIM/homeobox protein 1.1; LIM/homeobox protein LMX1A; LMX-1.1; shaker short-tail", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 7 (Disease Ontology:DOID:0110591)", "pathway": " (mmu:110648)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10693804", "class_list": "", "function": "Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0042048 olfactory behavior;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007613 memory;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JKU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08884-1", "uniprot_id": "KRA62_MOUSE", "mass": 15262.0, "length": 159, "protein_name": "Keratin-associated protein 6-2", "gene_name": "Krtap6-2", "organism": "Mouse", "refseq_name": "keratin-associated protein 6-2", "refseq_ac": "NP_034803", "gene_names_uniprotkb": "Krtap6-2", "gene_names_refseq": "HGTpII.4; Krtap6-2", "protein_names_uniprotkb": "Keratin-associated protein 6-2; HGTp type II.4; HgtpII.4; High-glycine tyrosine keratin type II.4", "protein_names_refseq": "HGTp type II.4; high-glycine tyrosine keratin type II.4; keratin-associated protein 6-2; keratin-associated protein 6.2", "tax_id": 10090, "disease": "", "pathway": " (mmu:16701)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15385554;15601842;21750661;9374545", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]; K6alpha, K6beta, and K17 have roles in normal development of the nail bed epithelium, [RefSeq, PubMed]; Krtap16 is a hair keratin-associated protein gene complex regulated by Hoxc13; localized to chromosome 16, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "GO:0001942 hair follicle development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O08884-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ22-1", "uniprot_id": "LTOR1_MOUSE", "mass": 17749.0, "length": 161, "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "Lamtor1", "organism": "Mouse", "refseq_name": "ragulator complex protein LAMTOR1", "refseq_ac": "NP_079881", "gene_names_uniprotkb": "Lamtor1", "gene_names_refseq": "2400001E08Rik; Lamtor1; Pdro; p18", "protein_names_uniprotkb": "Ragulator complex protein LAMTOR1; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18", "protein_names_refseq": "RhoA activator C11orf59 homolog; late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; lipid raft adaptor protein p18; p27Kip1-releasing factor from RhoA; p27RF-Rho; ragulator complex protein LAMTOR1; ragulator complex protein PDRO", "tax_id": 10090, "disease": "", "pathway": " (mmu:66508); (R-MMU-1632852); (R-MMU-165159); (R-MMU-166208); (R-MMU-380972); (R-MMU-5628897); (R-MMU-6798695); (R-MMU-8943724); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013407); (R-MMU-9013408); (R-MMU-9013423); (R-MMU-9639288)", "pathway_count": 15, "publication_count": 15, "publication_id_list": "15345747;17242355;19144319;19177150;21087931;21183079;21750661;25428506;29158492;29644770;30020076;30595499;34428180;35099830;35836818", "class_list": "", "function": "A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC., [RefSeq, PubMed]; Arterial cyclic stretch regulates Lamtor1 and promotes neointimal hyperplasia via circSlc8a1/miR-20a-5p axis in vein grafts. Publication Status: Online-Only, [RefSeq, PubMed]; Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:19177150, PubMed:29158492, PubMed:30020076). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:19177150, PubMed:29158492, PubMed:30020076). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:19177150). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:19177150). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (By similarity). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (PubMed:30595499). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (By similarity). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (By similarity). May also play a role in RHOA activation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function., [RefSeq, PubMed]; Lipid raft adaptor p18 is essential for anchoring the MEK-ERK pathway to late endosomes, and shed new light on a role of endosomal MEK-ERK pathway in controlling endosome dynamics., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYS0", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0051020 GTPase binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0000045 autophagosome assembly;GO:0043410 positive regulation of MAPK cascade;GO:0001919 regulation of receptor recycling;GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9CQ22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A591-1", "uniprot_id": "KRA31_MOUSE", "mass": 10271.0, "length": 98, "protein_name": "Keratin-associated protein 3-1", "gene_name": "Krtap3-1", "organism": "Mouse", "refseq_name": "keratin-associated protein 3-1", "refseq_ac": "NP_076000", "gene_names_uniprotkb": "Krtap3-1", "gene_names_refseq": "2310003K17Rik; KAP3.1; KRTAP3.1; Krtap3-1", "protein_names_uniprotkb": "Keratin-associated protein 3-1; High-sulfur keratin protein", "protein_names_refseq": "high-sulfur keratin protein; keratin-associated protein 3-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69473); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08634", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2A591-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A6H6A4-1", "uniprot_id": "LRIQ4_MOUSE", "mass": 68010.0, "length": 596, "protein_name": "Leucine-rich repeat and IQ domain-containing protein 4", "gene_name": "Lrriq4", "organism": "Mouse", "refseq_name": "leucine-rich repeat and IQ domain-containing protein 4 isoform 2", "refseq_ac": "NP_001277439", "gene_names_uniprotkb": "Lrriq4", "gene_names_refseq": "4930558O21Rik; Lrriq4", "protein_names_uniprotkb": "Leucine-rich repeat and IQ domain-containing protein 4", "protein_names_refseq": "leucine-rich repeat and IQ domain-containing protein 4 isoform 2; leucine-rich repeat and IQ domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:68307)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D5Q5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6H6A4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZPK7-1", "uniprot_id": "LST2_MOUSE", "mass": 99787.0, "length": 905, "protein_name": "Lateral signaling target protein 2 homolog", "gene_name": "Zfyve28", "organism": "Mouse", "refseq_name": "lateral signaling target protein 2 homolog", "refseq_ac": "NP_001015039", "gene_names_uniprotkb": "Zfyve28; Kiaa1643; Lst2", "gene_names_refseq": "9630058O20Rik; Gm146; Zfyve28; mKIAA1643", "protein_names_uniprotkb": "Lateral signaling target protein 2 homolog; Zinc finger FYVE domain-containing protein 28", "protein_names_refseq": "lateral signaling target protein 2 homolog; zinc finger FYVE domain-containing protein 28", "tax_id": 10090, "disease": "", "pathway": " (mmu:231125)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19460345;21750661;25428506", "class_list": "", "function": "Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RSX8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005829 cytosol;GO:0031901 early endosome membrane", "go_biological_process": "GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway;GO:0007175 negative regulation of epidermal growth factor-activated receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6ZPK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0R9-1", "uniprot_id": "LRRD1_MOUSE", "mass": 97132.0, "length": 853, "protein_name": "Leucine-rich repeat and death domain-containing protein 1", "gene_name": "Lrrd1", "organism": "Mouse", "refseq_name": "leucine-rich repeat and death domain-containing protein 1", "refseq_ac": "NP_766467", "gene_names_uniprotkb": "Lrrd1; 4932412H11Rik", "gene_names_refseq": "4932412H11Rik; Lrrd1", "protein_names_uniprotkb": "Leucine-rich repeat and death domain-containing protein 1", "protein_names_refseq": "leucine-rich repeat and death domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:242838)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RU96", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0006954 inflammatory response;GO:0035556 intracellular signal transduction;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C0R9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99PH1-1", "uniprot_id": "LRRC4_MOUSE", "mass": 72619.0, "length": 652, "protein_name": "Leucine-rich repeat-containing protein 4", "gene_name": "Lrrc4", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 4 precursor", "refseq_ac": "NP_619623", "gene_names_uniprotkb": "Lrrc4", "gene_names_refseq": "Lrrc4; MBAG1; NGL-2; NGL2; NLG-2; Nag14", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 4; Brain tumor-associated protein MBAG1; NGL-2; Netrin-G2 ligand", "protein_names_refseq": "LIBG-like protein; LRRC4-like protein; brain tumor-associated protein MBAG1; leucine-rich repeat-containing protein 4 precursor; leucine-rich repeat-containing protein 4; netrin-G2 ligand", "tax_id": 10090, "disease": "", "pathway": " (mmu:192198)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;15967442;16077900;16980967;17785411;17973922;21750661;29949768;30899004;32372061;33932995", "class_list": "", "function": "LRRC4 functions as a neuron-protective role in experimental autoimmune encephalomyelitis. Publication Status: Online-Only, [RefSeq, PubMed]; LRRC4 may play an important role in maintaining normal function and suppressing tumorigenesis in the central nervous system., [RefSeq, PubMed]; Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide., [RefSeq, PubMed]; Mice lacking NGL-2 (Lrrc4(-/-) mice) show suppressed N-Methyl-D-aspartate receptor (NMDAR)-dependent synaptic plasticity in the hippocampus. NGL-2 associates with NMDARs through both PSD-95-dependent and -independent mechanisms., [RefSeq, PubMed]; Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma., [UniProtKB, PubMed, PubMed, PubMed]; Together, these findings provide clues to the function of LRRC4 as a negative regulator of cell growth and underscore a link between the above-mentioned cyclins, cyclin-associated molecules and tumorigenicity., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q149E5;Q8VI35", "ec_number_list": "", "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0045202 synapse", "go_biological_process": "GO:1904861 excitatory synapse assembly;GO:0050808 synapse organization;GO:0050804 modulation of chemical synaptic transmission;GO:0099560 synaptic membrane adhesion;GO:0097119 postsynaptic density protein 95 clustering", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q99PH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CX60-1", "uniprot_id": "LBH_MOUSE", "mass": 12138.0, "length": 105, "protein_name": "Protein LBH", "gene_name": "Lbh", "organism": "Mouse", "refseq_name": "protein LBH", "refseq_ac": "NP_084275", "gene_names_uniprotkb": "Lbh", "gene_names_refseq": "1810009F10Rik; 6720416L16Rik; Lbh", "protein_names_uniprotkb": "Protein LBH; Limb bud and heart-expressed protein", "protein_names_refseq": "limb bud and heart-expressed protein; protein LBH", "tax_id": 10090, "disease": "", "pathway": " (mmu:77889)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11336496;15345747;15958514;19607824;21183079;21750661;33553423;33674448;34428180;34975330;36917392", "class_list": "", "function": "During endochondral bone formation, Lbh may negatively regulate vascular invasion and formation of the early ossification center at least in part by interfering with Runx2 and/or VEGF expression, [RefSeq, PubMed]; Exosomal LBH inhibits epithelial-mesenchymal transition and angiogenesis in nasopharyngeal carcinoma via downregulating VEGFA signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of LBH and SPP1 involved in hepatic stellate cell activation during liver fibrogenesis., [RefSeq, PubMed]; Modulates the activity of key transcription factors involved in cardiogenesis., [UniProtKB, PubMed, PubMed]; Overexpression of Limb Bud and Heart Alleviates Sepsis-Induced Acute Lung Injury via Inhibiting the NLRP3 Inflammasome. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription co-factor LBH is necessary for the survival of cochlear hair cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99MQ2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0060644 mammary gland epithelial cell differentiation;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CX60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08632-1", "uniprot_id": "KR195_MOUSE", "mass": 6688.0, "length": 62, "protein_name": "Keratin-associated protein 19-5", "gene_name": "Krtap19-5", "organism": "Mouse", "refseq_name": "keratin-associated protein 19-5", "refseq_ac": "NP_034806", "gene_names_uniprotkb": "Krtap19-5; Krtap8-2", "gene_names_refseq": "Krtap19-5; Krtap8-2", "protein_names_uniprotkb": "Keratin-associated protein 19-5; Glycine tyrosine-rich hair protein; HGTp type 1 alpha; High-glycine tyrosine keratin type 1 alpha; Keratin-associated protein 8-2", "protein_names_refseq": "HGTp type 1 alpha; HGTpI alpha; glycine tyrosine-rich hair protein; high-glycine tyrosine keratin type 1 alpha; keratin associated protein 8-2; keratin-associated protein 19-5; keratin-associated protein 8.2", "tax_id": 10090, "disease": "", "pathway": " (mmu:16704); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15385554;21750661;9374545", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB, UniProtKB, UniProtKB]; Krtap16 is a hair keratin-associated protein gene complex regulated by Hoxc13; localized to chromosome 16, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O08632-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08633-1", "uniprot_id": "KRA81_MOUSE", "mass": 6697.0, "length": 61, "protein_name": "Keratin-associated protein 8-1", "gene_name": "Krtap8-1", "organism": "Mouse", "refseq_name": "keratin-associated protein 8-1", "refseq_ac": "NP_034805", "gene_names_uniprotkb": "Krtap8-1", "gene_names_refseq": "Krtap8-1", "protein_names_uniprotkb": "Keratin-associated protein 8-1; HGT keratin; HGTp type I F; High-glycine/tyrosine protein keratin", "protein_names_refseq": "HGT keratin; HGTp type I F; HGTpI F; high-glycine/tyrosine protein keratin; keratin-associated protein 8-1; keratin-associated protein 8.1", "tax_id": 10090, "disease": "", "pathway": " (mmu:16703); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15385554;15840656;9374545", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]; Keratin-8 has a role in development of chronic spontaneous Th2 colitis, [RefSeq, PubMed]; Krtap16 is a hair keratin-associated protein gene complex regulated by Hoxc13; localized to chromosome 16, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZQ1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O08633-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54974-1", "uniprot_id": "LEG7_MOUSE", "mass": 15173.0, "length": 136, "protein_name": "Galectin-7", "gene_name": "Lgals7", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Lgals7", "gene_names_refseq": "", "protein_names_uniprotkb": "Galectin-7; Gal-7", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9697310", "class_list": "glycogene", "function": "Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 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"NP_032516", "gene_names_uniprotkb": "Lcat", "gene_names_refseq": "D8Wsu61e; Lcat", "protein_names_uniprotkb": "Phosphatidylcholine-sterol acyltransferase; 1-alkyl-2-acetylglycerophosphocholine esterase; 2.3.1.43; 3.1.1.47; Lecithin-cholesterol acyltransferase; PAF acetylhydrolase; Phospholipid-cholesterol acyltransferase; Platelet-activating factor acetylhydrolase", "protein_names_refseq": "1-alkyl-2-acetylglycerophosphocholine esterase; PAF acetylhydrolase; lecithin-cholesterol acyltransferase Lcat; phosphatidylcholine-sterol acyltransferase precursor; phosphatidylcholine-sterol acyltransferase; phospholipid-cholesterol acyltransferase; platelet-activating factor acetylhydrolase", "tax_id": 10090, "disease": "familial hyperlipidemia (Disease Ontology:DOID:1168); Norum disease (Disease Ontology:DOID:1391); arteriosclerosis (Disease Ontology:DOID:2349); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:16816); (R-MMU-8964058)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10393212;11809774;11893779;15654758;16944957;19065001;2600083;30742993;30899004;31219806;32777483;33020907;34321507;34428180;35984892;8820107", "class_list": "", "function": "Apolipoprotein A-I in mouse cerebrospinal fluid derives from the liver and intestine via plasma high-density lipoproteins assembled by ABCA1 and LCAT., [RefSeq, PubMed]; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:19065001). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels (PubMed:19065001). Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins (PubMed:19065001). Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:19065001). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:10393212). Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF (By similarity). Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Esterification of side-chain oxysterols by lysosomal phospholipase A2., [RefSeq, PubMed]; High density lipoproteins mediate in vivo protection against staphylococcal phenol-soluble modulins. Publication Status: Online-Only, [RefSeq, PubMed]; It has been reported that universal deletion of Apoa1 or Lcat expression in mice fed western-type diet results in increased sensitivity to body-weight gain compared to control C57BL/6 group., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 5, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8K139", "ec_number_list": "3.5.1.1;3.1.1.47;3.1.1.5;3.1.1.4;2.3.1.43;3.1.2.2;3.1.1.3;2.3.1.-;3.1.1.-;3.1.1.32;2.3.1.149", "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0047179 platelet-activating factor acetyltransferase activity;GO:0004623 phospholipase A2 activity;GO:0034186 apolipoprotein A-I binding;GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0034364 high-density lipoprotein particle", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0008203 cholesterol metabolic process;GO:0042157 lipoprotein metabolic process;GO:0042158 lipoprotein biosynthetic process;GO:0051384 response to glucocorticoid", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P16301-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59034-1", "uniprot_id": "LRRC3_MOUSE", "mass": 28119.0, "length": 257, "protein_name": "Leucine-rich repeat-containing protein 3", "gene_name": "Lrrc3", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 3 precursor", "refseq_ac": "NP_660134", "gene_names_uniprotkb": "Lrrc3", "gene_names_refseq": "1300011L04Rik; C21orf102; Lrrc3", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 3", "protein_names_refseq": "leucine-rich repeat-containing protein 3 precursor; leucine-rich repeat-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:237387)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12036297;26740625;30084848", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P59034-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2TA51-1", "uniprot_id": "KRA55_MOUSE", "mass": 23063.0, "length": 241, "protein_name": "Keratin-associated protein 5-5", "gene_name": "Krtap5-5", "organism": "Mouse", "refseq_name": "keratin-associated protein 5-5", "refseq_ac": "NP_001032911", "gene_names_uniprotkb": "Krtap5-5", "gene_names_refseq": "A030001H12Rik; Krtap5-5", "protein_names_uniprotkb": "Keratin-associated protein 5-5", "protein_names_refseq": "keratin-associated protein 5-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:114666); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TA51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V2C1-1", "uniprot_id": "KRA93_MOUSE", "mass": 13902.0, "length": 136, "protein_name": "Keratin-associated protein 9-3", "gene_name": "Krtap9-3", "organism": "Mouse", "refseq_name": "keratin-associated protein 9-3", "refseq_ac": "NP_083627", "gene_names_uniprotkb": "Krtap9-3", "gene_names_refseq": "2310040M23Rik; Krtap9-3", "protein_names_uniprotkb": "Keratin-associated protein 9-3; Keratin-associated protein 9.3; Ultrahigh sulfur keratin-associated protein 9.3", "protein_names_refseq": "keratin-associated protein 9-3; keratin-associated protein 9.3; ultrahigh sulfur keratin-associated protein 9.3", "tax_id": 10090, "disease": "", "pathway": " (mmu:75586); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D718", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3V2C1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61810-1", "uniprot_id": "LTBP3_MOUSE", "mass": 134363.0, "length": 1253, "protein_name": "Latent-transforming growth factor beta-binding protein 3", "gene_name": "Ltbp3", "organism": "Mouse", "refseq_name": "latent-transforming growth factor beta-binding protein 3 precursor", "refseq_ac": "NP_032546", "gene_names_uniprotkb": "Ltbp3", "gene_names_refseq": "Ltbp2; Ltbp3; mFLJ00070", "protein_names_uniprotkb": "Latent-transforming growth factor beta-binding protein 3; LTBP-3", "protein_names_refseq": "LTBP-3; latent-transforming growth factor beta-binding protein 3 precursor", "tax_id": 10090, "disease": "brachyolmia-amelogenesis imperfecta syndrome (Disease Ontology:DOID:0090143); geleophysic dysplasia 3 (Disease Ontology:DOID:0111727)", "pathway": " (mmu:16998); (R-MMU-2129379); (R-MMU-2173789)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10743502;11104663;12062452;21750661;30306291;34428180;7730318;9602168", "class_list": "", "function": "Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta., [UniProtKB, PubMed, PubMed]; This study demonstrates that LTBP-3/TGFbeta directly affects the biomechanical function of the thoracic aorta., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9474, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "F8VQ06;Q8BNQ6", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050431 transforming growth factor beta binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0001527 microfibril;GO:0071953 elastic fiber", "go_biological_process": "GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0045780 positive regulation of bone resorption;GO:0001501 skeletal system development;GO:0046849 bone remodeling;GO:0060349 bone morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q61810-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64280-1", "uniprot_id": "LFTY1_MOUSE", "mass": 41498.0, "length": 368, "protein_name": "Left-right determination factor 1", "gene_name": "Lefty1", "organism": "Mouse", "refseq_name": "left-right determination factor 1 preproprotein", "refseq_ac": "NP_034224", "gene_names_uniprotkb": "Lefty1; Ebaf; Lefty; Stra3; Tgfb4", "gene_names_refseq": "Ebaf; Leftb; Lefty1; Stra3; Tgfb4; lefty-1; lefty", "protein_names_uniprotkb": "Left-right determination factor 1; Lefty protein; Protein lefty-1; Stimulated by retinoic acid gene 3 protein; TGF-beta-4; Transforming growth factor beta-4", "protein_names_refseq": "TGF-beta-4; left-right determination factor 1 preproprotein; left-right determination, factor B; protein lefty-1; stimulated by retinoic acid gene 3 protein; transforming growth factor beta-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:13590); (R-MMU-114608)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "19224205;20173027;8610011;9496783;9708731", "class_list": "", "function": "Required for left-right axis determination as a regulator of LEFTY2 and NODAL., [UniProtKB, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. Mice lacking a functional copy of this gene exhibit embryonic lethality and defects in left-right patterning. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2A9", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005160 transforming growth factor beta receptor binding;GO:0008083 growth factor activity;GO:0038100 nodal binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:1900108 negative regulation of nodal signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0032526 response to retinoic acid;GO:0003007 heart morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q64280-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64507-1", "uniprot_id": "KRA51_MOUSE", "mass": 21782.0, "length": 230, "protein_name": "Keratin-associated protein 5-1", "gene_name": "Krtap5-1", "organism": "Mouse", "refseq_name": "keratin-associated protein 5-1", "refseq_ac": "NP_056623", "gene_names_uniprotkb": "Krtap5-1", "gene_names_refseq": "Krtap5-1", "protein_names_uniprotkb": "Keratin-associated protein 5-1; UHS-Ser-1; Ultra high sulfur serine protein 1", "protein_names_refseq": "UHS-Ser-1; keratin-associated protein 5-1; ultra high sulfur serine protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:50774); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "2250030", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4IF43", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q64507-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PFC5-1", "uniprot_id": "LRIT2_MOUSE", "mass": 61360.0, "length": 549, "protein_name": "Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2", "gene_name": "Lrit2", "organism": "Mouse", "refseq_name": "leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 isoform 1 precursor", "refseq_ac": "NP_775594", "gene_names_uniprotkb": "Lrit2; Lrrc22", "gene_names_refseq": "A930010E21Rik; Lrit2; Lrrc22", "protein_names_uniprotkb": "Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2; Leucine-rich repeat-containing protein 22", "protein_names_refseq": "leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 isoform 1 precursor; leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2; leucine-rich repeat-containing protein 22", "tax_id": 10090, "disease": "", "pathway": " (mmu:239038)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29590622", "class_list": "", "function": "Lrit2 is dispensable for photoreceptor synapse formation, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PFC5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPX9-1", "uniprot_id": "LEGLB_MOUSE", "mass": 18270.0, "length": 165, "protein_name": "Galectin-like protein 2", "gene_name": "Lgalsl2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Lgalsl2; Gm5065; Grpb; Lgalslb", "gene_names_refseq": "", "protein_names_uniprotkb": "Galectin-like protein 2; Galectin-related protein B; Lectin galactoside-binding-like protein B", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Does not bind lactose, and may not bind carbohydrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7TPX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BLY3-1", "uniprot_id": "LRFN3_MOUSE", "mass": 66056.0, "length": 626, "protein_name": "Leucine-rich repeat and fibronectin type-III domain-containing protein 3", "gene_name": "Lrfn3", "organism": "Mouse", "refseq_name": "leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor", "refseq_ac": "NP_780687", "gene_names_uniprotkb": "Lrfn3; Salm4", "gene_names_refseq": "A530045B06Rik; Lrfn3; SALM4", "protein_names_uniprotkb": "Leucine-rich repeat and fibronectin type-III domain-containing protein 3; Synaptic adhesion-like molecule 4", "protein_names_refseq": "leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor; leucine-rich repeat and fibronectin type-III domain-containing protein 3; synaptic adhesion-like molecule 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:233067); (R-MMU-8849932)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;16495444;16828986;18227064;18585462;34588597;40885482", "class_list": "", "function": "Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons., [UniProtKB, PubMed, PubMed]; Data show that the C-terminal PDZ binding domains of synaptic adhesion-like molecules (SALMs)1-3 are required for neurite outgrowth, and that the N-termini of SALMs 2 and 4 are alsoinvolved in neurite outgrowth., [RefSeq, PubMed]; SALM4 negatively regulates NMDA receptor function and fear memory consolidation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q505E2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0099560 synaptic membrane adhesion;GO:0099179 regulation of synaptic membrane adhesion;GO:1905606 regulation of presynapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BLY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1F0-1", "uniprot_id": "L10K_MOUSE", "mass": 10197.0, "length": 94, "protein_name": "Leydig cell tumor 10 kDa protein homolog", "gene_name": "D8Ertd738e", "organism": "Mouse", "refseq_name": "leydig cell tumor 10 kDa protein homolog", "refseq_ac": "NP_001007572", "gene_names_uniprotkb": "D8Ertd738e", "gene_names_refseq": "D8Ertd738e", "protein_names_uniprotkb": "Leydig cell tumor 10 kDa protein homolog", "protein_names_refseq": "leydig cell tumor 10 kDa protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:101966)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26495903;30779550;31219806;34428180", "class_list": "", "function": "May have a potential role in hypercalcemia of malignancy., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R1F0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q925H3-1", "uniprot_id": "KRA65_MOUSE", "mass": 7945.0, "length": 78, "protein_name": "Keratin-associated protein 6-5", "gene_name": "Krtap6-5", "organism": "Mouse", "refseq_name": "keratin-associated protein 6-5", "refseq_ac": "NP_570926", "gene_names_uniprotkb": "Krtap6-5; Krtap16-8; Krtap16.8", "gene_names_refseq": "1110002D05Rik; Krtap16-8; Krtap6-5", "protein_names_uniprotkb": "Keratin-associated protein 6-5; Keratin-associated protein 16-8; Keratin-associated protein 16.8", "protein_names_refseq": "keratin-associated protein 16-8; keratin-associated protein 16.8; keratin-associated protein 6-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:68484); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11290294;15385554;17151017", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]; Krtap16 is a hair keratin-associated protein gene complex regulated by Hoxc13; localized to chromosome 16, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "GO:0031424 keratinization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q925H3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D5Z7-1", "uniprot_id": "KRA52_MOUSE", "mass": 17234.0, "length": 189, "protein_name": "Keratin-associated protein 5-2", "gene_name": "Krtap5-2", "organism": "Mouse", "refseq_name": "keratin-associated protein 5-2", "refseq_ac": "NP_082120", "gene_names_uniprotkb": "Krtap5-2", "gene_names_refseq": "4833428E21Rik; Krtap5-2", "protein_names_uniprotkb": "Keratin-associated protein 5-2", "protein_names_refseq": "keratin-associated protein 5-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:71623); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D5Z7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JL15-1", "uniprot_id": "LEG8_MOUSE", "mass": 36162.0, "length": 316, "protein_name": "Galectin-8", "gene_name": "Lgals8", "organism": "Mouse", "refseq_name": "galectin-8 isoform 1", "refseq_ac": "NP_001185972", "gene_names_uniprotkb": "Lgals8", "gene_names_refseq": "1200015E08Rik; D13Ertd524e; Lgals-8; Lgals8", "protein_names_uniprotkb": "Galectin-8; Gal-8; LGALS-8", "protein_names_refseq": "galectin-8 isoform 1; galectin-8L; galectin-8; lectin, galactose binding, soluble 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:56048)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17893094;19401394;21091438;21753146;26495903;31219806;34428180;36702375;37828378;38232701", "class_list": "glycogene", "function": "A novel role for Gal-8 in collaboration with Gal-1 in plasma cell formation, and suggest the possibility of using distinct LacNAc ligands to modulate the function of Gals., [RefSeq, PubMed]; Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans., [UniProtKB, UniProtKB]; Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors., [RefSeq, PubMed]; Galectin-8 involves in arthritic condylar bone loss via podoplanin/AKT/ERK axis-mediated inflammatory lymphangiogenesis., [RefSeq, PubMed]; Galectin-8 is expressed in the thymus in mouse, which suggests an active role for this lectin in shaping the mature T cell repertoire, [RefSeq, PubMed]; Taken together, our findings support a distinctive role for locally produced Gal-8 as an enhancer of otherwise borderline immune responses and also suggest that Gal-8 might fuel the reactivity at inflammatory foci., [RefSeq, PubMed]; The findings of the present study delineate the differential molecular requirements for Gal-8 activities on T-cells, and suggest a dual activity relying on activation state., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0031295 T cell costimulation;GO:0098792 xenophagy;GO:0098586 cellular response to virus;GO:0002317 plasma cell differentiation;GO:1904977 lymphatic endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JL15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z127-1", "uniprot_id": "LAT1_MOUSE", "mass": 55872.0, "length": 512, "protein_name": "Large neutral amino acids transporter small subunit 1", "gene_name": "Slc7a5", "organism": "Mouse", "refseq_name": "large neutral amino acids transporter small subunit 1", "refseq_ac": "NP_035534", "gene_names_uniprotkb": "Slc7a5; Lat1", "gene_names_refseq": "4F2LC; D0H16S474E; Gm42049; LAT1; Slc7a5; TA1", "protein_names_uniprotkb": "Large neutral amino acids transporter small subunit 1; 4F2 LC; 4F2 light chain; 4F2LC; L-type amino acid transporter 1; LAT1; Solute carrier family 7 member 5", "protein_names_refseq": "4F2 LC; 4F2 light chain; L-type amino acid transporter 1; large neutral amino acids transporter small subunit 1; solute carrier family 7 member 5", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); large cell neuroendocrine carcinoma (Disease Ontology:DOID:0050872); autism spectrum disorder (Disease Ontology:DOID:0060041); adenoid cystic carcinoma (Disease Ontology:DOID:0080202); lung pleomorphic carcinoma (Disease Ontology:DOID:0080899); stomach cancer (Disease Ontology:DOID:10534); esophageal carcinoma (Disease Ontology:DOID:1107); esophagitis (Disease Ontology:DOID:11963); rectum adenocarcinoma (Disease Ontology:DOID:1996); colon cancer (Disease Ontology:DOID:219); transitional cell carcinoma (Disease Ontology:DOID:2671); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); extrahepatic bile duct adenocarcinoma (Disease Ontology:DOID:3495); gastric adenocarcinoma (Disease Ontology:DOID:3717); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); bile duct adenocarcinoma (Disease Ontology:DOID:4896); bile duct carcinoma (Disease Ontology:DOID:4897); cholangiocarcinoma (Disease Ontology:DOID:4947); hepatocellular carcinoma (Disease Ontology:DOID:684); malignant pleural mesothelioma (Disease Ontology:DOID:7474); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:20539); (R-MMU-210991); (R-MMU-352230); (R-MMU-71240)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "10574970;11011012;11117468;16085056;18250455;20173027;22645316;25428506;25428507;25605945;26495903;27802388;28011936;28935714;30084848;31599954;33649389;34428180;37828378;9915839", "class_list": "", "function": "In a neuronal cell model, y+,L and y+ transport systems are the predominant form of arginine uptake mechanisms and the transport of arginine is altered by membrane potential and redox factors., [RefSeq, PubMed]; The heterodimer with SLC3A2 functions as a sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, histidine, met hionine, tryptophan, valine, isoleucine and alanine (By similarity). The heterodimer with SLC3A2 mediates the uptake of L-DOPA and leucine (PubMed:11011012, PubMed:9915839). Functions as an amino acid exchanger (By similarity). May play a role in the transport of L-DOPA across the blood-brain barrier (PubMed:11011012). May act as the major transporter of tyrosine in fibroblasts (By similarity). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). Can mediate the transport of thyroid hormones diiodothyronine (T2), triiodothyronine (T3) and thyroxine (T4) across the cell membrane. When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (By similarity). Mediates the uptake of 3-iodo-L-tyrosine (MIT) and 3,5-diiodo-L-tyrosine (DIT) (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 28, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0X8;Q9JMI4", "ec_number_list": "", "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0015196 L-tryptophan transmembrane transporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:0032740 positive regulation of interleukin-17 production;GO:0015820 L-leucine transport;GO:0015824 proline transport;GO:0032328 alanine transport", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9Z127-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923B3-1", "uniprot_id": "NRIF1_MOUSE", "mass": 93650.0, "length": 828, "protein_name": "Neurotrophin receptor-interacting factor 1", "gene_name": "Nrif1; Zfp110", "organism": "Mouse", "refseq_name": "neurotrophin receptor-interacting factor 1", "refseq_ac": "NP_075357", "gene_names_uniprotkb": "Nrif1; Zfp110; Nrif; Zfp110", "gene_names_refseq": "2900024E01Rik; NRIF; Nrif1; Zfp110", "protein_names_uniprotkb": "Neurotrophin receptor-interacting factor 1; Neurotrophin receptor-interacting factor; Zinc finger protein 110", "protein_names_refseq": "neurotrophin receptor interacting factor; neurotrophin receptor-interacting factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:65020); (R-MMU-212436)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10545116;11750124;12935912;14960584;15668238;16252010;16630834;18677445;18815271;21750661;21952136;30059200;31219806;34428180", "class_list": "", "function": "Data show that in vitro down regulation of NRIF expression decreased the mRNA for two main cholesterogenic enzymes, 3-hydroxy-3-methylglutaryl-coenzyme A reductase and 7-dehydrocholesterol reductase., [RefSeq, PubMed]; NRIF gene expression gradually decreassedas development progressed., [RefSeq, PubMed]; Transcription regulator involved in NGFR/p75(NTR)-mediated apoptosis. Essential component of the NGFR/p75(NTR) apoptotic pathway: upon ligand-binding and subsequent cleavage of NGFR/p75(NTR), binds to the intracellular domain (ICD) cleavage product of NGFR/p75(NTR), translocates to the nucleus and induces apoptosis, possibly by regulating expression of key regulators of apoptosis. Induces NGFR/p75(NTR)-mediated apoptosis in retina and sympathetic neurons. May also regulate expression of neuronal cholesterol biosynthesis genes. Probably acts as a transcription repressor: specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BS00;Q9D6I6;Q9QZ07", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0005166 neurotrophin p75 receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0051402 neuron apoptotic process;GO:0046328 regulation of JNK cascade;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q923B3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C0P8-1", "uniprot_id": "NPS_MOUSE", "mass": 9861.0, "length": 89, "protein_name": "Neuropeptide S", "gene_name": "Nps", "organism": "Mouse", "refseq_name": "neuropeptide S precursor", "refseq_ac": "NP_001157083", "gene_names_uniprotkb": "Nps", "gene_names_refseq": "Nps", "protein_names_uniprotkb": "Neuropeptide S", "protein_names_refseq": "neuropeptide S precursor", "tax_id": 10090, "disease": "morphine dependence (Disease Ontology:DOID:2560)", "pathway": " (mmu:100043254); (R-MMU-375276); (R-MMU-416476); (R-MMU-418555)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "16279934;18628994;19429110;19616051;21150909;21750661", "class_list": "", "function": "Analysis of a neuropeptide S responsive circuitry shaping amygdala activity via the endopiriform nucleus Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that lithium evokes antagonistic effects on the mediation of hyperlocomotion and protection against lipid peroxidation induced by neuropeptide S., [RefSeq, PubMed]; Ligand for NPSR1. Binds to its receptor with nanomolar affinity and initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway. This results in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels (By similarity). In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction (By similarity). Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade (By similarity). Modulates arousal and anxiety. May play an important anorexigenic role (PubMed:16279934)., [UniProtKB, PubMed, UniProtKB]; NPS facilitates spatial memory and mitigates MK801-induced spatial memory impairment in mice., [RefSeq, PubMed]; Neuropeptide S knock-out mice display deficits in inhibitory avoidance memory indicating involvement in central noradrenergic systems., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0160041 neuropeptide activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0008542 visual learning;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0032230 positive regulation of synaptic transmission, GABAergic;GO:0051968 positive regulation of synaptic transmission, glutamatergic", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P0C0P8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61971-1", "uniprot_id": "NTF2_MOUSE", "mass": 14478.0, "length": 127, "protein_name": "Nuclear transport factor 2", "gene_name": "Nutf2", "organism": "Mouse", "refseq_name": "nuclear transport factor 2", "refseq_ac": "NP_080808", "gene_names_uniprotkb": "Nutf2; Ntf2", "gene_names_refseq": "2700067I02Rik; Ntf2; Ntf3; Nutf2; PP15", "protein_names_uniprotkb": "Nuclear transport factor 2; NTF-2", "protein_names_refseq": "nuclear transport factor 2", "tax_id": 10090, "disease": "diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:68051)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Has a role in nuclear-cytoplasmic transport of proteins and mRNAs., [UniProtKB, UniProtKB]; Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P13662;Q3TI35", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031267 small GTPase binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0005637 nuclear inner membrane;GO:0044613 nuclear pore central transport channel", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0006611 protein export from nucleus;GO:0051028 mRNA transport;GO:0090204 protein localization to nuclear pore;GO:1904046 negative regulation of vascular endothelial growth factor production", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P61971-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TV70-1", "uniprot_id": "NR2CA_MOUSE", "mass": 15857.0, "length": 140, "protein_name": "Nuclear receptor 2C2-associated protein", "gene_name": "Nr2c2ap", "organism": "Mouse", "refseq_name": "nuclear receptor 2C2-associated protein isoform 1", "refseq_ac": "NP_001020757", "gene_names_uniprotkb": "Nr2c2ap; Tra16", "gene_names_refseq": "2310073E15Rik; Nr2c2ap", "protein_names_uniprotkb": "Nuclear receptor 2C2-associated protein; TR4 orphan receptor-associated 16 kDa protein", "protein_names_refseq": "TR4 orphan receptor-associated 16 kDa protein; nuclear receptor 2C2-associated protein isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75692)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3TV70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80XC6-1", "uniprot_id": "NRDE2_MOUSE", "mass": 133467.0, "length": 1172, "protein_name": "Nuclear exosome regulator NRDE2", "gene_name": "Nrde2", "organism": "Mouse", "refseq_name": "nuclear exosome regulator NRDE2 isoform a", "refseq_ac": "NP_001277232", "gene_names_uniprotkb": "Nrde2", "gene_names_refseq": "6720454P05Rik; Nrde2", "protein_names_uniprotkb": "Nuclear exosome regulator NRDE2; Protein NRDE2 homolog", "protein_names_refseq": "UPF0614 protein C14orf102 homolog; nuclear exosome regulator NRDE2 isoform a; nuclear exosome regulator NRDE2; protein NRDE2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:217827)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;34428180;37137667", "class_list": "", "function": "Mouse nuclear RNAi-defective 2 promotes splicing of weak 5' splice sites., [RefSeq, PubMed]; Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation. Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation. Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome. By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (By similarity). U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre-mRNA and plays an important role in centrosome maturation, integrity and function during mitosis (By similarity). Suppresses intron retention in a subset of pre-mRNAs containing short, GC-rich introns with relatively weak 5' and 3' splice sites (By similarity). Plays a role in DNA damage response (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKV8;Q8R3D7;Q99LT9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0016607 nuclear speck", "go_biological_process": "GO:0046833 positive regulation of RNA export from nucleus;GO:0000278 mitotic cell cycle;GO:0006397 mRNA processing;GO:0048255 mRNA stabilization;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80XC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JI75-1", "uniprot_id": "NQO2_MOUSE", "mass": 26248.0, "length": 231, "protein_name": "Ribosyldihydronicotinamide dehydrogenase [quinone]", "gene_name": "Nqo2", "organism": "Mouse", "refseq_name": "ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1", "refseq_ac": "NP_001156713", "gene_names_uniprotkb": "Nqo2; Nmor2", "gene_names_refseq": "NMO2; Nmor2; Nqo2; Ox2", "protein_names_uniprotkb": "Ribosyldihydronicotinamide dehydrogenase [quinone]; 1.10.5.1; NRH dehydrogenase [quinone] 2; NRH:quinone oxidoreductase 2; QR2; Quinone reductase 2", "protein_names_refseq": "NAD(P)H dehydrogenase, quinone 2; NAD(P)H menadione oxidoreductase 2, dioxin inducible; NRH dehydrogenase [quinone] 2; NRH: quinone oxidoreductase; NRH:quinone oxidoreductase 2; QR2; quinone reductase 2; ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1; ribosyldihydronicotinamide dehydrogenase", "tax_id": 10090, "disease": "agranulocytosis (Disease Ontology:DOID:12987); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (mmu:18105); (R-MMU-211945)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10903442;12351651;21750661;23554006;24142791;25428506;29526807;30084848;33046554;37507081", "class_list": "", "function": "Dopamine-Dependent QR2 Pathway Activation in CA1 Interneurons Enhances Novel Memory Formation., [RefSeq, PubMed]; Melatonin, acting at least partially via MT2 receptors, can regulate the redox status of quinone reductase II inhibited preadipocytes., [RefSeq, PubMed]; NQO2 stabilization of C/EBPalpha was independent of NQO1, even though both interacted with the same C/EBPa domain., [RefSeq, PubMed]; Role for NQO2 in protection against myelogenous hyperplasia and in metabolic activation of menadione, leading to hepatic toxicity, [RefSeq, PubMed]; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These data suggest that the overexpression of QR2 in brain cells in the presence of catechol quinones might lead to reactive oxygen species-induced cell death via the rapid conversion of superoxide radicals into hydrogen peroxide and then into highly reactive hydroxyl radicals, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.10.5.1", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0009055 electron transfer activity;GO:0042803 protein homodimerization activity;GO:0071949 FAD binding;GO:0031404 chloride ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation;GO:2000379 positive regulation of reactive oxygen species metabolic process;GO:0043525 positive regulation of neuron apoptotic process;GO:1901662 quinone catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JI75-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99ME9-1", "uniprot_id": "GTPB4_MOUSE", "mass": 74113.0, "length": 634, "protein_name": "GTP-binding protein 4", "gene_name": "Gtpbp4", "organism": "Mouse", "refseq_name": "GTP-binding protein 4 isoform 1", "refseq_ac": "NP_081276", "gene_names_uniprotkb": "Gtpbp4; Crfg; Nog1", "gene_names_refseq": "2610028C09Rik; Crfg; Gtpbp3; Gtpbp4; NGB; Nog1", "protein_names_uniprotkb": "GTP-binding protein 4; Chronic renal failure gene protein; GTP-binding protein NGB; Nucleolar GTP-binding protein 1", "protein_names_refseq": "GTP binding protein 3; GTP-binding protein 4 isoform 1; Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB); chronic renal failure gene protein; chronic renal failure protein", "tax_id": 10090, "disease": "end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:69237)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11316846;11473111;17785438;18250455;18299400;20173027;21183079;21750661;25428506;25428507;25605945;33649389;34428180;35820727;37410776;37828378;39627609", "class_list": "", "function": "Involved in the biogenesis of the 60S ribosomal subunit. Acts as TP53 repressor, preventing TP53 stabilization and cell cycle arrest., [UniProtKB, UniProtKB]; NOG1 downregulates type I interferon production by targeting phosphorylated interferon regulatory factor 3. Publication Status: Online-Only, [RefSeq, PubMed]; Resonance Raman spectroscopy was used to determine the structure of the heme environment in Ngb from mice., [RefSeq, PubMed]; These results suggest that conformational changes in the switch II element of Nog1 have a critical importance for the dissociation of preribosome-bound factors during intranucleolar maturation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99K16;Q99P78;Q9CT02", "ec_number_list": "", "go_molecular_function": "GO:1990275 preribosome binding;GO:0003723 RNA binding;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0030336 negative regulation of cell migration;GO:0042273 ribosomal large subunit biogenesis;GO:0050821 protein stabilization;GO:0022408 negative regulation of cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q99ME9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6R2P8-1", "uniprot_id": "NEIL2_MOUSE", "mass": 36834.0, "length": 329, "protein_name": "Endonuclease 8-like 2", "gene_name": "Neil2", "organism": "Mouse", "refseq_name": "endonuclease 8-like 2", "refseq_ac": "NP_963904", "gene_names_uniprotkb": "Neil2; Gm1212", "gene_names_refseq": "Gm1212; NEH2; Neil2", "protein_names_uniprotkb": "Endonuclease 8-like 2; 3.2.2.-; 4.2.99.18; DNA glycosylase/AP lyase Neil2; DNA-(apurinic or apyrimidinic site) lyase Neil2; Endonuclease VIII-like 2; NEH2; Nei homolog 2; Nei-like protein 2", "protein_names_refseq": "DNA glycosylase/AP lyase Neil2; DNA-(apurinic or apyrimidinic site) lyase Neil2; endonuclease 8-like 2; endonuclease VIII-like 2; nei homolog 2; nei-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:382913); (R-MMU-110329); (R-MMU-5649702)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15533836;15725623;16581765;16920106;20175991;21750661;25428506;33932404;34857879;37423306", "class_list": "", "function": "Intrapulmonary administration of purified NEIL2 abrogates NF-kappaB-mediated inflammation., [RefSeq, PubMed]; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)., [UniProtKB]; Keap1 recruits NEH2 through binding to ETGE and DLG motifs., [RefSeq, PubMed]; NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice. Publication Status: Online-Only, [RefSeq, PubMed]; NEIL1 and NEIL2 are essential in the recognition of oxidized lesions arising from 8-oxoG and may play important roles in the repair of DNA damage induced by carcinogenic metals., [RefSeq, PubMed]; Nei-like DNA glycosylase 2 selectively antagonizes interferon-beta expression upon respiratory syncytial virus infection., [RefSeq, PubMed]; Recombinant human DNA Polymerase beta and recombinant mpise NEIL2 associated with microtubules in situ and in vivo., [RefSeq, PubMed]; Results suggest a role for NEIL1 and 2 as backup deoxyribo-5'-phosphate lyases in mammalian cells., [RefSeq, PubMed]; The beta2/beta3 loop where Lys50 is located in NEIL2 is important for DNA binding, presumably lies next to a phosphate-binding site, and may represent a target for regulation of the enzyme activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X969", "ec_number_list": "4.2.99.18;3.2.2.-;1.14.11.51;1.14.11.-;1.14.11.33;5.6.2.4;6.5.1.1;2.7.7.7;4.2.99.-", "go_molecular_function": "GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0019104 DNA N-glycosylase activity;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0015630 microtubule cytoskeleton;GO:0072686 mitotic spindle", "go_biological_process": "GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6R2P8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4P1-1", "uniprot_id": "NPB_MOUSE", "mass": 13018.0, "length": 119, "protein_name": "Neuropeptide B", "gene_name": "Npb", "organism": "Mouse", "refseq_name": "neuropeptide B isoform 1 precursor", "refseq_ac": "NP_695020", "gene_names_uniprotkb": "Npb", "gene_names_refseq": "Npb; PPL7; mPPL7", "protein_names_uniprotkb": "Neuropeptide B; L7C; Preproprotein L7; mPPL7", "protein_names_refseq": "neuropeptide B isoform 1 precursor; preproneuropeptide B; preproprotein L7", "tax_id": 10090, "disease": "", "pathway": " (mmu:208990); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12118011;12719537;12925742;15983370;21750661", "class_list": "", "function": "Has an effect in food intake, on locomotor activity and has an analgesic effect, (in vivo pharmacological studies). May be involved in the regulation of neuroendocrine system, memory and learning (By similarity)., [UniProtKB]; Identified a neuropeptide modified with bromine; an endogenous ligand for GPR7, [RefSeq, PubMed]; NPB is a factor in the modulation of responses to inflammatory pain and body weight homeostasis., [RefSeq, PubMed]; Role for GPR7 and its endogenous ligands, neuropeptide B and neuropeptide W, in regulating energy homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0007631 feeding behavior", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K4P1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1F1-1", "uniprot_id": "NIBA2_MOUSE", "mass": 84819.0, "length": 749, "protein_name": "Protein Niban 2", "gene_name": "Niban2", "organism": "Mouse", "refseq_name": "protein Niban 2", "refseq_ac": "NP_666231", "gene_names_uniprotkb": "Niban2; Fam129b", "gene_names_refseq": "9130404D14Rik; Fam129b; Meg-3; Niban2", "protein_names_uniprotkb": "Protein Niban 2; Meg-3; Niban-like protein 1; Protein FAM129B", "protein_names_refseq": "family with sequence similarity 129, member B; niban-like protein 1; protein Niban 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:227737)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "19892989;20173027;21148485;21183079;21750661;22977259;25428506;25428507;27802388;30084848;30779550;31219806;31599954;34428180;36442234", "class_list": "", "function": "FAM129B is a cooperative protein that regulates adipogenesis., [RefSeq, PubMed]; Fam129b in epidermal keratinocytes accompanied by alteration of wound healing-related gene expression is necessary for regulation of cell motility., [RefSeq, PubMed]; May play a role in apoptosis suppression., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCV6;Q3U8I3;Q3UC84;Q3UDW4;Q3UIE4;Q543S7;Q8BQ71;Q8CC78", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0032274 gonadotropin secretion;GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8R1F1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CYI0-1", "uniprot_id": "NJMU_MOUSE", "mass": 44422.0, "length": 393, "protein_name": "Protein Njmu-R1", "gene_name": "5730455P16Rik", "organism": "Mouse", "refseq_name": "protein Njmu-R1", "refseq_ac": "NP_081748", "gene_names_uniprotkb": "5730455P16Rik", "gene_names_refseq": "5730455P16Rik", "protein_names_uniprotkb": "Protein Njmu-R1", "protein_names_refseq": "protein Njmu-R1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70591)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;25428506;29084197;30084848;34203471;34428180;35820727", "class_list": "", "function": "May have a role in spermatogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TMQ9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0099041 vesicle tethering to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CYI0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ER97-1", "uniprot_id": "NGB_MOUSE", "mass": 17037.0, "length": 151, "protein_name": "Neuroglobin", "gene_name": "Ngb", "organism": "Mouse", "refseq_name": "neuroglobin isoform 2", "refseq_ac": "NP_071859", "gene_names_uniprotkb": "Ngb", "gene_names_refseq": "Ngb", "protein_names_uniprotkb": "Neuroglobin; 1.7.-.-; Nitrite reductase", "protein_names_refseq": "neuroglobin isoform 2; nitrite reductase", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); retinal ischemia (Disease Ontology:DOID:12510); transient cerebral ischemia (Disease Ontology:DOID:224); encephalitis (Disease Ontology:DOID:9588)", "pathway": " (mmu:64242); (R-MMU-8981607)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11029004;11473111;11473128;12048231;15162488;15548613;21750661;22659017;31219806;32205448;35797699;35822521;38796706", "class_list": "", "function": "A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning., [RefSeq, PubMed]; Ligand binding and protein dynamics, [RefSeq, PubMed]; Monomeric globin with a bis-histidyl six-coordinate heme-iron atom through which it can bind dioxygen, carbon monoxide and nitric oxide (PubMed:11029004, PubMed:11473111, PubMed:11473128). Could help transport oxygen and increase its availability to the metabolically active neuronal tissues, though its low quantity in tissues as well as its high affinity for dioxygen, which may limit its oxygen-releasing ability, argue against it (PubMed:11029004, PubMed:11473128). The ferrous/deoxygenated form exhibits a nitrite reductase activity and it could produce nitric oxide which in turn inhibits cellular respiration in response to hypoxia. In its ferrous/deoxygenated state, it may also exhibit GDI (Guanine nucleotide Dissociation Inhibitor) activity toward heterotrimeric G-alpha proteins, thereby regulating signal transduction to facilitate neuroprotective responses in the wake of hypoxia and associated oxidative stress (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Neuroglobin deficiency increases seizure susceptibility but does not affect basal behavior in mice., [RefSeq, PubMed]; Neuroglobin overexpression in cerebellar neurons of Harlequin mice improves mitochondrial homeostasis and reduces ataxic behavior., [RefSeq, PubMed]; Probing the Role of Murine Neuroglobin CDloop-D-Helix Unit in CO Ligand Binding and Structural Dynamics., [RefSeq, PubMed]; Resonance Raman spectroscopy was used to determine the structure of the heme environment in Ngb from mice., [RefSeq, PubMed]; The paper describes the discovery of neuroglobin, the oxygen-binding properties (P50 = 1-2 Torr), and its preferential expression in the mouse brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.11.1.-;1.7.-.-;1.15.1.1;1.14.12.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0005092 GDP-dissociation inhibitor activity;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0043204 perikaryon", "go_biological_process": "GO:0031175 neuron projection development;GO:0043066 negative regulation of apoptotic process;GO:0001666 response to hypoxia;GO:0043085 positive regulation of catalytic activity;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9ER97-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPT5-1", "uniprot_id": "NOP16_MOUSE", "mass": 21139.0, "length": 178, "protein_name": "Nucleolar protein 16", "gene_name": "Nop16", "organism": "Mouse", "refseq_name": "nucleolar protein 16", "refseq_ac": "NP_848720", "gene_names_uniprotkb": "Nop16; D13Wsu177e", "gene_names_refseq": "D13Wsu177e; Nop16", "protein_names_uniprotkb": "Nucleolar protein 16", "protein_names_refseq": "NOP16 nucleolar protein homolog; nucleolar protein 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:28126)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;21863248;28528544;31219806;34428180", "class_list": "", "function": "Tumor environments with relatively high Myc levels would have different coexpression patterns of Nop16 than tumor environments with relatively low Myc levels., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2P2;Q921K0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CPT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTX4-1", "uniprot_id": "NRG4_MOUSE", "mass": 12744.0, "length": 115, "protein_name": "Pro-neuregulin-4, membrane-bound isoform", "gene_name": "Nrg4", "organism": "Mouse", "refseq_name": "pro-neuregulin-4, membrane-bound isoform isoform 2", "refseq_ac": "NP_114391", "gene_names_uniprotkb": "Nrg4", "gene_names_refseq": "Nrg4", "protein_names_uniprotkb": "Pro-neuregulin-4, membrane-bound isoform; Pro-NRG4", "protein_names_refseq": "pro-NRG4; pro-neuregulin-4, membrane-bound isoform isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:83961)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10348342;21750661;23033483;31219806;38015639;38823457", "class_list": "", "function": "Adipocyte secreted NRG4 ameliorates age-associated metabolic dysfunction., [RefSeq, PubMed]; Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors., [UniProtKB, PubMed]; Neuregulin 4 mediates the metabolic benefits of mild cold exposure by promoting beige fat thermogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Pharmacological inhibition of PI3K/Akt signaling reversed the anti-apoptotic effects of NRG4, confirming the role of this cascade in NRG4-induced cell survival, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0038138 ERBB4-ERBB4 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WTX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70572-1", "uniprot_id": "NSMA_MOUSE", "mass": 47467.0, "length": 419, "protein_name": "Sphingomyelin phosphodiesterase 2", "gene_name": "Smpd2", "organism": "Mouse", "refseq_name": "sphingomyelin phosphodiesterase 2", "refseq_ac": "NP_033239", "gene_names_uniprotkb": "Smpd2", "gene_names_refseq": "Smpd2; nSMase1; nSMase", "protein_names_uniprotkb": "Sphingomyelin phosphodiesterase 2; 3.1.4.12; Lyso-PAF-PLC; Lyso-platelet-activating factor-phospholipase C; N-SMase; Neutral sphingomyelinase; nSMase", "protein_names_refseq": "N-SMase; lyso-PAF-PLC; lyso-platelet-activating factor-phospholipase C; neutral sphingomyelinase 1; sphingomyelin phosphodiesterase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:20598); (R-MMU-5626978); (R-MMU-9840310)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11997500;15764706;21750661;34428180;35294731;37904133;9520418", "class_list": "glycogene", "function": "Catalyzes, at least in vitro, the hydrolysis of sphingomyelin to form ceramide and phosphocholine (PubMed:9520418). Also hydrolyzes 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor) in vivo (By similarity). Also acts on 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and sphingosylphosphocholine (By similarity)., [UniProtKB, PubMed, UniProtKB]; Neutral Sphingomyelinase 2 Mediates Oxidative Stress Effects on Astrocyte Senescence and Synaptic Plasticity Transcripts., [RefSeq, PubMed]; Neutral sphingomyelinase 1 deficiency in the mouse causes no lipid storage disease. (nSMase 1), [RefSeq, PubMed]; Neutral sphingomyelinase inhibition promotes local and network degeneration in vitro and in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein with similarity to the human nSMase1 protein. In humans, the nSMase1 protein was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 31, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.12;3.1.4.3;3.1.4.38;3.1.4.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008081 phosphoric diester hydrolase activity;GO:0004767 sphingomyelin phosphodiesterase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0005901 caveola", "go_biological_process": "GO:0030149 sphingolipid catabolic process;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0046513 ceramide biosynthetic process;GO:0006672 ceramide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O70572-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEJ4-1", "uniprot_id": "NLE1_MOUSE", "mass": 53134.0, "length": 485, "protein_name": "Notchless protein homolog 1", "gene_name": "Nle1", "organism": "Mouse", "refseq_name": "notchless protein homolog 1", "refseq_ac": "NP_663406", "gene_names_uniprotkb": "Nle1", "gene_names_refseq": "Nle1; Nle; l11Jus1; l11Jus4", "protein_names_uniprotkb": "Notchless protein homolog 1", "protein_names_refseq": "Notchless gene homolog; notchless protein homolog 1; novel WD40 repeat containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:217011)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16611995;21750661;23231322;24875805;30478226;34019907", "class_list": "", "function": "Activated skeletal muscle satellite cells in conditional Nle mutant mice are arrested in proliferation; however, deletion of Nle in myofibres does not impair myogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown of NLE1 inhibits development of malignant melanoma in vitro and in vivo NLE1 promotes development of malignant melanoma. Erratum:[Exp Cell Res. 2021 Aug 15;405(2):112733. doi: 10.1016/j.yexcr.2021.112733. PMID: 34274105], [RefSeq, PubMed]; Plays a role in regulating Notch activity (Probable). Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival., [UniProtKB, PubMed, PubMed]; These data demonstrate an essential role for Nle1 during organogenesis and in particular during axial development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1ARD5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005634 nucleus", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0001822 kidney development;GO:0042273 ribosomal large subunit biogenesis;GO:0045930 negative regulation of mitotic cell cycle;GO:0001756 somitogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VEJ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0A5-1", "uniprot_id": "NEK3_MOUSE", "mass": 57464.0, "length": 511, "protein_name": "Serine/threonine-protein kinase Nek3", "gene_name": "Nek3", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase Nek3 isoform 1", "refseq_ac": "NP_001156419", "gene_names_uniprotkb": "Nek3", "gene_names_refseq": "Nek3", "protein_names_uniprotkb": "Serine/threonine-protein kinase Nek3; 2.7.11.1; Never in mitosis A-related kinase 3; NimA-related protein kinase 3", "protein_names_refseq": "NIMA-related expressed kinase 3; never in mitosis A-related kinase 3; nimA-related protein kinase 3; serine/threonine-protein kinase Nek3 isoform 1; serine/threonine-protein kinase Nek3", "tax_id": 10090, "disease": "", "pathway": " (mmu:23954)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10224116;10393247;15345747;17242355;19509051;21183079;21750661", "class_list": "", "function": "Data show that Nek3 influences neuronal morphogenesis and polarity through effects on microtubules., [RefSeq, PubMed]; Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QLM2;Q9Z0X9", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon", "go_biological_process": "GO:0090043 regulation of tubulin deacetylation;GO:0006468 protein phosphorylation;GO:0051301 cell division;GO:0048812 neuron projection morphogenesis;GO:0030010 establishment of cell polarity", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9R0A5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VIH1-1", "uniprot_id": "NOBOX_MOUSE", "mass": 57565.0, "length": 527, "protein_name": "Homeobox protein NOBOX", "gene_name": "Nobox", "organism": "Mouse", "refseq_name": "homeobox protein NOBOX", "refseq_ac": "NP_570939", "gene_names_uniprotkb": "Nobox; Og2x", "gene_names_refseq": "Nobox; OG2; Og2x", "protein_names_uniprotkb": "Homeobox protein NOBOX; Homeodomain-containing protein OG-2; Newborn ovary homeobox protein; Oocyte-specific homeobox protein", "protein_names_refseq": "OG2 homeobox; homeobox protein NOBOX; homeodomain-containing protein OG-2; newborn ovary homeobox protein; oocyte-specific homeobox protein", "tax_id": 10090, "disease": "primary ovarian insufficiency 5 (Disease Ontology:DOID:0080862)", "pathway": " (mmu:18291)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11804785;15326356;16997917;17701902;21750661;25428506;8855241", "class_list": "", "function": "Nobox is critical for specifying an oocyte-restricted gene expression pattern essential for postnatal follicle development, [RefSeq, PubMed]; Transcription factor which plays an essential role in postnatal follicle development. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'. Directly regulates the transcription of POU5F1 and GDF9 during early folliculogenesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P70367", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001541 ovarian follicle development;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VIH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VC65-1", "uniprot_id": "NRM_MOUSE", "mass": 29435.0, "length": 262, "protein_name": "Nurim", "gene_name": "Nrm", "organism": "Mouse", "refseq_name": "nurim", "refseq_ac": "NP_598883", "gene_names_uniprotkb": "Nrm", "gene_names_refseq": "2610307M02Rik; Nrm", "protein_names_uniprotkb": "Nurim; Nuclear envelope membrane protein; Nuclear rim protein", "protein_names_refseq": "nuclear envelope membrane protein; nuclear rim protein; nurim", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741)", "pathway": " (mmu:106582)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;28600179;34428180", "class_list": "", "function": "Study describes Nurim isoform expression during development and correlate these expression patterns with developmental timing and spatial patterns. The reasons for increased expression of the Nurim isoforms were not clear; however, results suggest that increased expression may be involved in cardiac development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1W6AWH1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0031965 nuclear membrane;GO:0005637 nuclear inner membrane;GO:0005652 nuclear lamina", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VC65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D035-1", "uniprot_id": "NKAI1_MOUSE", "mass": 23551.0, "length": 207, "protein_name": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1", "gene_name": "Nkain1", "organism": "Mouse", "refseq_name": "sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 isoform 1", "refseq_ac": "NP_080274", "gene_names_uniprotkb": "Nkain1; Fam77c", "gene_names_refseq": "2610200G18Rik; 2810426C15Rik; Nkain1", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1; Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 1; Protein FAM77C", "protein_names_refseq": "Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 1; sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 isoform 1; sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67149)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;17606467;21750661;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6MHP4;Q9D0Q6", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002028 regulation of sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D035-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08692-1", "uniprot_id": "NGP_MOUSE", "mass": 19332.0, "length": 167, "protein_name": "Neutrophilic granule protein", "gene_name": "Ngp", "organism": "Mouse", "refseq_name": "neutrophilic granule protein precursor", "refseq_ac": "NP_032720", "gene_names_uniprotkb": "Ngp", "gene_names_refseq": "Ngp; bectenecin", "protein_names_uniprotkb": "Neutrophilic granule protein; Cystatin-like protein; Myeloid bactenecin protein; Myeloid secondary granule protein; NGP", "protein_names_refseq": "clone B6; cystatin-like protein; myeloid bactenecin protein; myeloid granule protein; myeloid secondary granule protein; neutrophilic granule protein precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:18054)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12515729;21518852;26495903;34428180;8749713;8839844", "class_list": "", "function": "Acts as an inhibitor of cathepsin B (CTSB) activity. Plays a role as a negative regulator of tumor vascular development, cell invasion and metastasis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61903", "ec_number_list": "", "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:1901491 negative regulation of lymphangiogenesis;GO:0006952 defense response;GO:0016525 negative regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O08692-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35375-1", "uniprot_id": "NRP2_MOUSE", "mass": 104631.0, "length": 931, "protein_name": "Neuropilin-2", "gene_name": "Nrp2", "organism": "Mouse", "refseq_name": "neuropilin-2 isoform 1 precursor", "refseq_ac": "NP_001070871", "gene_names_uniprotkb": "Nrp2", "gene_names_refseq": "1110048P06Rik; Np-2; Np2; Npn-2; Npn2; Nrp2", "protein_names_uniprotkb": "Neuropilin-2; Vascular endothelial cell growth factor 165 receptor 2", "protein_names_refseq": "neuropilin-2 isoform 1 precursor; vascular endothelial cell growth factor 165 receptor 2", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:18187); (R-MMU-194306)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;18250455;27802388;32152506;35820727;37828378;9331348", "class_list": "glycogene", "function": "High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 42, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B1AT44;O35373;O35374;O35376;O35377;O35378", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0017154 semaphorin receptor activity;GO:0005021 vascular endothelial growth factor receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0097490 sympathetic neuron projection extension;GO:0097491 sympathetic neuron projection guidance;GO:0001525 angiogenesis;GO:0007507 heart development;GO:0071526 semaphorin-plexin signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O35375-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35604-1", "uniprot_id": "NPC1_MOUSE", "mass": 142885.0, "length": 1277, "protein_name": "NPC intracellular cholesterol transporter 1", "gene_name": "Npc1", "organism": "Mouse", "refseq_name": "NPC intracellular cholesterol transporter 1 precursor", "refseq_ac": "NP_032746", "gene_names_uniprotkb": "Npc1", "gene_names_refseq": "A430089E03Rik; D18Ertd139e; D18Ertd723e; Npc1; lcsd; nmf164; spm", "protein_names_uniprotkb": "NPC intracellular cholesterol transporter 1; Niemann-Pick C1 protein", "protein_names_refseq": "NPC intracellular cholesterol transporter 1 precursor; Niemann-Pick type C1; niemann-Pick C1 protein; sphingomyelinosis", "tax_id": 10090, "disease": "Niemann-Pick disease type C1 (Disease Ontology:DOID:0070113); Niemann-Pick disease (Disease Ontology:DOID:14504)", "pathway": " (mmu:18145); (R-MMU-8964038)", "pathway_count": 2, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;16340014;18250455;18299400;20173027;20484733;21412152;21896731;22048958;22065762;22645316;22872234;25428506;25605945;26495903;27551080;27802388;28011936;30084848;30779550;30899004;31219806;31599954;34203471;34428180;35820727;37828378;9211850", "class_list": "", "function": "Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PubMed:21896731, PubMed:22048958, PubMed:27551080). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (By similarity). Mediates cholesterol transfer from lysosomes to endoplasmic reticulum by tethering endosomal/lysosomal compartments and endoplasmic reticulum membrane contact sites where it interacts with sterol transport protein GRAMD1B (By similarity). May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Inhibits cholesterol-mediated mTORC1 activation throught its interaction with SLC38A9 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 9, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 2, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "G3X8W9;O35605", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005635 nuclear envelope;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0031579 membrane raft organization;GO:1904036 negative regulation of epithelial cell apoptotic process;GO:0001889 liver development;GO:0006897 endocytosis;GO:0008203 cholesterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "O35604-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35627-1", "uniprot_id": "NR1I3_MOUSE", "mass": 40913.0, "length": 358, "protein_name": "Nuclear receptor subfamily 1 group I member 3", "gene_name": "Nr1i3", "organism": "Mouse", "refseq_name": "nuclear receptor subfamily 1 group I member 3 isoform 2", "refseq_ac": "NP_001229991", "gene_names_uniprotkb": "Nr1i3; Car", "gene_names_refseq": "CAR-beta; CAR; Care2; ESTM32; MB67; Nr1i3", "protein_names_uniprotkb": "Nuclear receptor subfamily 1 group I member 3; CAR; Constitutive androstane receptor; Orphan nuclear receptor MB67", "protein_names_refseq": "constitutive androstane receptor; constitutively transactivates RAREs; nuclear receptor subfamily 1 group I member 3 isoform 2; orphan nuclear receptor MB67", "tax_id": 10090, "disease": "cholestasis (Disease Ontology:DOID:13580)", "pathway": " (mmu:12355); (R-MMU-383280)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10462436;14573755;15610733;17904126;21750661;25428506;28751364;30084848;34428180;35285501;37759441;38128062;8603043;9295294", "class_list": "", "function": "Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity)., [UniProtKB, PubMed]; CAR Protects Females from Diet-Induced Steatosis and Associated Metabolic Disorders. Publication Status: Online-Only, [RefSeq, PubMed]; Impact of Neonatal Activation of Nuclear Receptor CAR (Nr1i3) on Cyp2 Gene Expression in Adult Mouse Liver., [RefSeq, PubMed]; Interaction with YAP underlies the species differences between humans and rodents in CAR-dependent hepatocyte proliferation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35628;Q3V008", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O35627-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35683-1", "uniprot_id": "NDUA1_MOUSE", "mass": 8139.0, "length": 70, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1", "gene_name": "Ndufa1", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1", "refseq_ac": "NP_062316", "gene_names_uniprotkb": "Ndufa1", "gene_names_refseq": "1810049F12Rik; MWFE; Ndufa1", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1; CI-MWFE; Complex I-MWFE; NADH-ubiquinone oxidoreductase MWFE subunit", "protein_names_refseq": "CI-MWFE; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 (7.5kD, MWFE); NADH dehydrogenase 1 alpha subcomplex, 1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1; NADH ubiquinone oxidoreductase subunit MWFE; NADH-ubiquinone oxidoreductase MWFE subunit; complex I-MWFE", "tax_id": 10090, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); nuclear type mitochondrial complex I deficiency 12 (Disease Ontology:DOID:0112099)", "pathway": " (mmu:54405); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "11937507;20484733;22872234;25428506;27802388;30084848;33649389;34203471;34428180;35820727;36210013;36288343;38575788", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:38575788). Complex I functions in the transfer of electrons from NADH to the respiratory chain (PubMed:38575788). The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)., [UniProtKB, UniProtKB, PubMed]; Species-specific and mutant MWFE proteins effect on the assembly of a functional mammalian mitochondrial complex I., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O35683-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35710-1", "uniprot_id": "NOCT_MOUSE", "mass": 48301.0, "length": 429, "protein_name": "Nocturnin", "gene_name": "Noct", "organism": "Mouse", "refseq_name": "nocturnin", "refseq_ac": "NP_033964", "gene_names_uniprotkb": "Noct; Ccr4; Ccrn4l; Noc", "gene_names_refseq": "Ccr4; Ccrn4l; Noct", "protein_names_uniprotkb": "Nocturnin; 3.1.3.108; Carbon catabolite repression 4-like protein", "protein_names_refseq": "CCR4 carbon catabolite repression 4-like; CCR4 protein homolog; carbon catabolite repression 4 homolog; carbon catabolite repression 4-like protein; circadian deadenylase NOC; nocturnin", "tax_id": 10090, "disease": "", "pathway": " (mmu:12457)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10521507;11394964;17400819;20392228;20498072;20685873;21750661;21820310;22073225;22082366;22331129;23449310;29187734;29386110;29860338;31219806;31879354;37400970;9038221", "class_list": "", "function": "Circadian control of Nocturnin and its regulatory role in health and disease. Review article, [RefSeq, PubMed]; Nocturnin exhibits circadian rhythmicity of mRNA abundance with peak levels at the time of light offset in the retina, spleen, heart, kidney and liver., [RefSeq, PubMed]; Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (By similarity). Shows a small preference for NADPH over NADP(+) (By similarity). Represses translation and promotes degradation of target mRNA molecules (By similarity). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (PubMed:20498072, PubMed:20685873). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (PubMed:20498072, PubMed:21820310, PubMed:22073225, PubMed:22082366, PubMed:22331129). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (PubMed:20498072, PubMed:22082366). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (PubMed:20498072). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (PubMed:20685873, PubMed:22073225). Critical for proper development of early embryos (PubMed:23449310)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Posttranscriptional control by Nocturnin regulates the amplitude of critical metabolic pathways, and loss of this activity results in increased metabolic flux and reduced obesity, [RefSeq, PubMed]; The Noct gene encodes a protein (NOC) that is highly conserved with the endonuclease/exonuclease/phosphatase (EEP) domain-containing CCR4 family of deadenylases, but highly purified NOC possesses little or no ribonuclease activity. NOC utilizes the dinucleotide NADP(H) as a substrate, removing the 2' phosphate to generate NAD(H), and is a direct regulator of oxidative stress response through its NADPH 2' phosphatase activ, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZG9", "ec_number_list": "3.1.3.108", "go_molecular_function": "GO:0003729 mRNA binding;GO:0046872 metal ion binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity;GO:0019178 NADP phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0006739 NADP+ metabolic process;GO:0010629 negative regulation of gene expression;GO:0032496 response to lipopolysaccharide;GO:0045600 positive regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "O35710-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70342-1", "uniprot_id": "NPY5R_MOUSE", "mass": 52785.0, "length": 466, "protein_name": "Neuropeptide Y receptor type 5", "gene_name": "Npy5r", "organism": "Mouse", "refseq_name": "neuropeptide Y receptor type 5", "refseq_ac": "NP_057917", "gene_names_uniprotkb": "Npy5r; Npy5", "gene_names_refseq": "NPY5-R; NPYY5-R; Npy5r; Y5R", "protein_names_uniprotkb": "Neuropeptide Y receptor type 5; NPY-Y5 receptor; NPY5-R; NPYY5-R; Y5 receptor", "protein_names_refseq": "NPY-Y5 receptor; Y5 receptor; neuropeptide Y receptor type 5", "tax_id": 10090, "disease": "peripheral artery disease (Disease Ontology:DOID:0050830); absence epilepsy (Disease Ontology:DOID:0070309); alcohol use disorder (Disease Ontology:DOID:1574); hyperinsulinism (Disease Ontology:DOID:2018); lipid metabolism disorder (Disease Ontology:DOID:3146); coronary restenosis (Disease Ontology:DOID:4247); prolactinoma (Disease Ontology:DOID:5394); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:18168); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "28485050;31999643;9315606;9802393", "class_list": "", "function": "Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer., [RefSeq, PubMed]; Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders (By similarity)., [UniProtKB]; Study suggests that PYY3-36 mediated signalling via Y5 receptors may counteract the anorectic effects that it mediates via the Y2 receptor, consequently lowering bodyweight in the absence of Y5 signalling., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O35380;Q9JMK1", "ec_number_list": "", "go_molecular_function": "GO:0004983 neuropeptide Y receptor activity;GO:0001601 peptide YY receptor activity;GO:0001602 pancreatic polypeptide receptor activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043005 neuron projection;GO:0098793 presynapse", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045471 response to ethanol;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O70342-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10493-1", "uniprot_id": "NID1_MOUSE", "mass": 136538.0, "length": 1245, "protein_name": "Nidogen-1", "gene_name": "Nid1", "organism": "Mouse", "refseq_name": "nidogen-1 precursor", "refseq_ac": "NP_035047", "gene_names_uniprotkb": "Nid1; Ent", "gene_names_refseq": "A630025O17; Nid1; Nid; entactin-1; entactin; nidogen-1", "protein_names_uniprotkb": "Nidogen-1; Entactin; NID-1", "protein_names_refseq": "NID-1; Nidogen precursor (Entactin); entactin 1; nidogen-1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:18073); (R-MMU-1474228); (R-MMU-3000157)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11427896;11589703;16574105;2496973;3084254;31219806;3264556;33725478;35984892;36408877;36792666;37507081;37828378;7601446;8224873;8326911;9299350;9501082", "class_list": "", "function": "Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions., [UniProtKB]; Transmembrane serine protease 2 cleaves nidogen 1 and inhibits extrahepatic liver cancer cell migration and invasion., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 7, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKX9;Q8BQI3;Q8C3U8;Q8C9P6", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005518 collagen binding;GO:0043236 laminin binding;GO:0050840 extracellular matrix binding;GO:0043394 proteoglycan binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0071944 cell periphery;GO:0005604 basement membrane", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0045785 positive regulation of cell adhesion;GO:0007160 cell-matrix adhesion;GO:0010811 positive regulation of cell-substrate adhesion;GO:0051149 positive regulation of muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P10493-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20181-1", "uniprot_id": "NTF3_MOUSE", "mass": 29588.0, "length": 258, "protein_name": "Neurotrophin-3", "gene_name": "Ntf3", "organism": "Mouse", "refseq_name": "neurotrophin-3 isoform a precursor", "refseq_ac": "NP_001157506", "gene_names_uniprotkb": "Ntf3; Ntf-3", "gene_names_refseq": "HDNF; NGF-2; Nt3; Ntf-3; Ntf3", "protein_names_uniprotkb": "Neurotrophin-3; HDNF; NGF-2; NT-3; Nerve growth factor 2; Neurotrophic factor", "protein_names_refseq": "nerve growth factor 2; neurotrophic factor; neurotrophin-3 isoform a precursor", "tax_id": 10090, "disease": "atrial heart septal defect 1 (Disease Ontology:DOID:0110106); Alzheimer's disease (Disease Ontology:DOID:10652); hydrocephalus (Disease Ontology:DOID:10908); pulmonary sarcoidosis (Disease Ontology:DOID:13406); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); borna disease (Disease Ontology:DOID:5154); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (mmu:18205); (R-MMU-1257604); (R-MMU-6811558); (R-MMU-9034013); (R-MMU-9034793); (R-MMU-9603381)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "2314473;38212372;38639409;7957235", "class_list": "", "function": "Neurotrophin-3 from the dentate gyrus supports postsynaptic sites of mossy fiber-CA3 synapses and hippocampus-dependent cognitive functions., [RefSeq, PubMed]; Seems to promote the survival of visceral and proprioceptive sensory neurons., [UniProtKB]; This gene encodes a member of the neurotrophins that have a wide variety of functions in both neural and non-neural tissues. The encoded preproprotein undergoes proteolytic processing to generate a noncovalently linked homodimeric mature protein that can bind to the transmembrane receptor tyrosine kinases to initiate a series of signaling events. Mice lacking the encoded protein exhibit severe defects in the peripheral nervous system including a complete lack of spinal proprioceptive afferents and their peripheral sense organs. [provided by RefSeq, Sep 2016]., [RefSeq]; Vascular smooth muscle cell-derived nerve growth factor regulates sympathetic collateral branching to innervate blood vessels in embryonic skin., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0048406 nerve growth factor binding;GO:0042056 chemoattractant activity;GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding;GO:0005166 neurotrophin p75 receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0031410 cytoplasmic vesicle;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0045687 positive regulation of glial cell differentiation;GO:0042490 mechanoreceptor differentiation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007274 neuromuscular synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P20181-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42586-1", "uniprot_id": "NKX22_MOUSE", "mass": 30126.0, "length": 273, "protein_name": "Homeobox protein Nkx-2.2", "gene_name": "Nkx2-2", "organism": "Mouse", "refseq_name": "homeobox protein Nkx-2.2 isoform 1", "refseq_ac": "NP_035049", "gene_names_uniprotkb": "Nkx2-2; Nkx-2.2; Nkx2b", "gene_names_refseq": "Nkx-2.2; Nkx2-2; Nkx2.2; tinman", "protein_names_uniprotkb": "Homeobox protein Nkx-2.2; Homeobox protein NK-2 homolog B", "protein_names_refseq": "Drosophila NK2 transcription factor related, locus 2; glycoprotein GP330, renal; homeobox protein NK-2 homolog B; homeobox protein Nkx-2.2 isoform 1; homeobox protein Nkx-2.2; homeobox protein Nkx2-2", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); demyelinating disease (Disease Ontology:DOID:3213)", "pathway": " (mmu:18088)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11076772;1346742;14573534;19759004;7939711;8654958", "class_list": "", "function": "Transcriptional activator involved in the development of insulin-producing beta cells in the endocrine pancreas (PubMed:11076772). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (PubMed:19759004)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P42586-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47937-1", "uniprot_id": "NK3R_MOUSE", "mass": 51026.0, "length": 452, "protein_name": "Neuromedin-K receptor", "gene_name": "Tacr3", "organism": "Mouse", "refseq_name": "neuromedin-K receptor", "refseq_ac": "NP_067357", "gene_names_uniprotkb": "Tacr3; Tac3r", "gene_names_refseq": "Nk3r; Nkr; Tac3r; Tacr3", "protein_names_uniprotkb": "Neuromedin-K receptor; NK-3 receptor; NK-3R; NKR; Neurokinin B receptor; Tachykinin receptor 3", "protein_names_refseq": "NK-3 receptor; Nk3 receptor; neurokinin 3 receptor; neurokinin B receptor; neuromedin K receptor; neuromedin-K receptor", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); hypogonadotropic hypogonadism 11 with or without anosmia (Disease Ontology:DOID:0090071); hypertension (Disease Ontology:DOID:10763); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:21338); (R-MMU-380095); (R-MMU-416476)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12773411;15501700;36453600;36756128;38057665;8120392", "class_list": "", "function": "A novel antidiuretic hormone governs tumour-induced renal dysfunction., [RefSeq, PubMed]; NK3-receptors are not involved in the development of lung inflammation and inflammatory cell recruitment into airways of antigen-challenged mice., [RefSeq, PubMed]; Receptor for the tachykinin neuromedin-K (neurokinin B), also able to bind and respond to tachynins substance K/neurokinin A and substance P. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P. Neuromedin-K binding to its receptor triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C. Neuromedin-K binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP)., [UniProtKB, UniProtKB]; Tachykinin NK3 receptor genes are expressed in uterine cells, oocytes, ovaries and embryos from mice, and may play a role in female reproductive function., [RefSeq, PubMed]; Tachykinin receptor 3 in the lateral habenula alleviates pain and anxiety comorbidity in mice. Publication Status: Online-Only, [RefSeq, PubMed]; The overexpression of neurokinin B-neurokinin 3 receptor system exerts direct effects on the ovary under PCOS-like conditions to interfere with mitochondrial function., [RefSeq, PubMed]; This gene belongs to a family of genes that function as receptors for tachykinins. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Mar 2010]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q61968;Q8BL44;Q9JKN0", "ec_number_list": "", "go_molecular_function": "GO:0004995 tachykinin receptor activity;GO:0016498 neuromedin K receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043679 axon terminus;GO:0032809 neuronal cell body membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0045777 positive regulation of blood pressure;GO:0010460 positive regulation of heart rate;GO:0032355 response to estradiol;GO:0042220 response to cocaine", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P47937-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49681-1", "uniprot_id": "NPBW1_MOUSE", "mass": 36076.0, "length": 329, "protein_name": "Neuropeptides B/W receptor type 1", "gene_name": "Npbwr1", "organism": "Mouse", "refseq_name": "neuropeptides B/W receptor type 1", "refseq_ac": "NP_034472", "gene_names_uniprotkb": "Npbwr1; Gpr7", "gene_names_refseq": "Gpr7; Nbpwr1; Npbwr1", "protein_names_uniprotkb": "Neuropeptides B/W receptor type 1; G protein-coupled receptor 7", "protein_names_refseq": "G protein-coupled receptor 7; neuropeptides B/W receptor type 1", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:226304); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12925742;20051645;21390312;25428506;30609248;7590751", "class_list": "", "function": "Data demonstrate that GPR7 mRNA showed a significant circadian rhythm in the suprachiasmatic nucleus showing a peak at early subjective night in both light-dark and constant dark, [RefSeq, PubMed]; Important roles of NPBWR1 in regulating amygdala function during physical and social stress. Publication Status: Online-Only, [RefSeq, PubMed]; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity)., [UniProtKB]; Role for GPR7 and its endogenous ligands, neuropeptide B and neuropeptide W, in regulating energy homeostasis., [RefSeq, PubMed]; The neuropeptide W (NPW) mRNA quickly elevated in the early differentiation (7-14 days) of ATDC5 cells, while NPW and neuropeptides B/W receptor 1 (GPR7) mRNA were reduced during the late stage (14-21 days) of differentiation., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008188 neuropeptide receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P49681-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70447-1", "uniprot_id": "NGN2_MOUSE", "mass": 28216.0, "length": 263, "protein_name": "Neurogenin-2", "gene_name": "Neurog2", "organism": "Mouse", "refseq_name": "neurogenin-2", "refseq_ac": "NP_033848", "gene_names_uniprotkb": "Neurog2; Ath4a; Atoh4; Ngn2", "gene_names_refseq": "Atoh4; Math4A; Neurog2; bHLHa8; ngn-2; ngn2", "protein_names_uniprotkb": "Neurogenin-2; Helix-loop-helix protein mATH-4A; NGN-2; Protein atonal homolog 4; mATH4A", "protein_names_refseq": "helix-loop-helix protein mATH-4A; neurogenin-2; protein atonal homolog 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:11924)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14697366;16202708;18400164;8948587;9000438", "class_list": "", "function": "Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3')., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70237", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0070888 E-box binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030900 forebrain development;GO:0045666 positive regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P70447-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97466-1", "uniprot_id": "NOGG_MOUSE", "mass": 25770.0, "length": 232, "protein_name": "Noggin", "gene_name": "Nog", "organism": "Mouse", "refseq_name": "noggin precursor", "refseq_ac": "NP_032737", "gene_names_uniprotkb": "Nog", "gene_names_refseq": "Nog", "protein_names_uniprotkb": "Noggin", "protein_names_refseq": "noggin precursor", "tax_id": 10090, "disease": "proximal symphalangism (Disease Ontology:DOID:0050788); tarsal-carpal coalition syndrome (Disease Ontology:DOID:0050789); esophageal atresia/tracheoesophageal fistula (Disease Ontology:DOID:0080171); proximal symphalangism 1 (Disease Ontology:DOID:0080787); multiple synostoses syndrome 1 (Disease Ontology:DOID:0081317); brachydactyly type B2 (Disease Ontology:DOID:0110975); acute kidney tubular necrosis (Disease Ontology:DOID:12556); Huntington's disease (Disease Ontology:DOID:12858); craniosynostosis (Disease Ontology:DOID:2340); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); cleft lip (Disease Ontology:DOID:9296); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hyperopia (Disease Ontology:DOID:9834)", "pathway": " (mmu:18121); (R-MMU-201451)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;9585504;9603738", "class_list": "", "function": "Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite (PubMed:9585504, PubMed:9603738). Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019838 growth factor binding;GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding;GO:0141069 receptor ligand inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030424 axon;GO:0098793 presynapse;GO:0032991 protein-containing complex", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0040036 regulation of fibroblast growth factor receptor signaling pathway;GO:0048570 notochord morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P97466-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VF94-1", "uniprot_id": "NKPD1_MOUSE", "mass": 66831.0, "length": 599, "protein_name": "NTPase KAP family P-loop domain-containing protein 1", "gene_name": "Nkpd1", "organism": "Mouse", "refseq_name": "NTPase KAP family P-loop domain-containing protein 1 isoform 1", "refseq_ac": "NP_081392", "gene_names_uniprotkb": "Nkpd1", "gene_names_refseq": "2310015G09Rik; Nkpd1", "protein_names_uniprotkb": "NTPase KAP family P-loop domain-containing protein 1", "protein_names_refseq": "NTPase KAP family P-loop domain-containing protein 1 isoform 1; NTPase KAP family P-loop domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69547)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15935074;20173027;21750661;31599954", "class_list": "", "function": "Altered membrane NTPase activity is a biochemical hallmark of HPRT deficiency, but species and cell-type differences have to be considered, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D7C6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q0VF94-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2LKU9-1", "uniprot_id": "NLR1A_MOUSE", "mass": 134308.0, "length": 1182, "protein_name": "NACHT, LRR and PYD domains-containing protein 1a", "gene_name": "Nlrp1a", "organism": "Mouse", "refseq_name": "NACHT, LRR and PYD domains-containing protein 1a", "refseq_ac": "NP_001004142", "gene_names_uniprotkb": "Nlrp1a; Card7; Nalp1a; Nalp1; Nlrp1", "gene_names_refseq": "CARD7; DEFCAP; Gm14; Gm15; NAC; Nalp1a; Nalp1; Nlrp1a; Nlrp1; PP1044", "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 1a; 3.4.-.-; Caspase recruitment domain-containing protein 7; Death effector filament-forming ced-4-like apoptosis protein; Nucleotide-binding domain and caspase recruitment domain", "protein_names_refseq": "NACHT, LRR and PYD containing protein 1; NACHT, LRR and PYD domains-containing protein 1a; NACHT, leucine rich repeat and PYD containing 1; NACHT/LRR/pyrin domain-containing protein 1; NLR family, pyrin domain containing 1A, CAST/EiJ strain specific; NLR family, pyrin domain containing 1A, PWK/PhJ strain specific; NLR family, pyrin domain containing 1A, WSB/EiJ strain specific; NLR family, pyrin domain containing 1; caspase recruitment domain protein; caspase recruitment domain-containing protein 7; death effector filament-forming Ced-4-like apoptosis protein; nucleotide-binding domain and caspase recruitment domain", "tax_id": 10090, "disease": "vitiligo (Disease Ontology:DOID:12306)", "pathway": " (mmu:195046); (R-MMU-844455)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "16429160;18495787;18511561;23219391;23506131;25605945;31383852;34428180;35820727;36210013;37245530;37507081;37625833;38178196;38976128", "class_list": "", "function": "Acts as the sensor component of the Nlrp1a inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis (PubMed:23219391). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (By similarity). Acts as a recognition receptor (PRR): recognizes specific pathogens and other damage-associated signals, and mediates the formation of the inflammasome polymeric complex (By similarity). In response to pathogen-associated signals, the N-terminal part of Nlrp1a is degraded by the proteasome, releasing the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1a, C-terminus), which polymerizes to initiate the formation of the inflammasome complex: the inflammasome recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), leading to pyroptosis (By similarity). In the absence of GSDMD expression, the Nlrp1a inflammasome is able to recruit and activate CASP8, leading to activation of gasdermin-E (GSDME) (By similarity). Activation of Nlrp1a inflammasome is also required for HMGB1 secretion; the active cytokines and HMGB1 stimulate inflammatory responses (By similarity). When activated in the bone marrow, induces the pyroptosis of hematopoietic stem cells and progenitor cells of both myeloid and lymphoid lineages, hence allowing the removal of damaged cells, and the release of IL1B, which induces granulopoiesis (PubMed:23219391)., [UniProtKB, PubMed, UniProtKB]; Autophagy dysfunction contributes to NLRP1 inflammasome-linked depressive-like behaviors in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Chronic hypoxia of endothelial cells boosts HIF-1alpha-NLRP1 circuit in Alzheimer's disease., [RefSeq, PubMed]; Constitutes the active part of the Nlrp1a inflammasome (By similarity). In absence of pathogens and other damage-associated signals, interacts with the N-terminal part of Nlrp1a (NACHT, LRR and PYD domains-containing protein 1a, N-terminus), preventing activation of the Nlrp1a inflammasome (By similarity). In response to pathogen-associated signals, the N-terminal part of Nlrp1a is degraded by the proteasome, releasing this form, which polymerizes to form the Nlrp1a inflammasome complex: the Nlrp1a inflammasome complex then directly recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, leading to gasdermin-D (GSDMD) cleavage and subsequent pyroptosis (By similarity)., [UniProtKB, UniProtKB]; Constitutes the precursor of the Nlrp1a inflammasome, which mediates autoproteolytic processing within the FIIND domain to generate the N-terminal and C-terminal parts, which are associated non-covalently in absence of pathogens and other damage-associated signals., [UniProtKB, UniProtKB]; MiR-122-3p Alleviates LPS-Induced Pyroptosis of Macrophages via Targeting NLRP1., [RefSeq, PubMed]; NOD2 can associate with NALP1 to form a complex that activates caspase-1 in response to muramyl dipeptide., [RefSeq, PubMed]; New in vivo function of NOD2 within the eye which yet distinguishes NOD2-dependent from NALP3-dependent inflammation., [RefSeq, PubMed]; Regulatory part that prevents formation of the Nlrp1a inflammasome: in absence of pathogens and other damage-associated signals, interacts with the C-terminal part of Nlrp1a (NACHT, LRR and PYD domains-containing protein 1a, C-terminus), preventing activation of the Nlrp1a inflammasome (By similarity). In response to pathogen-associated signals, this part is ubiquitinated and degraded by the proteasome, releasing the cleaved C-terminal part of the protein, which polymerizes and forms the Nlrp1a inflammasome (By similarity)., [UniProtKB, UniProtKB]; Thioredoxin-1 Protects Neurons Through Inhibiting NLRP1-Mediated Neuronal Pyroptosis in Models of Alzheimer's Disease. Erratum:[Mol Neurobiol. 2025 May;62(5):6626. doi: 10.1007/s12035-024-04523-8. PMID: 39333348], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M4T3K8;M4T4C8;M4T632;M4TJP5;Q3U0B5;Q67EY4", "ec_number_list": "3.4.-.-", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:0002221 pattern recognition receptor signaling pathway;GO:1904784 NLRP1 inflammasome complex assembly;GO:0006954 inflammatory response;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q2LKU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UHX8-1", "uniprot_id": "NKX63_MOUSE", "mass": 28779.0, "length": 262, "protein_name": "Homeobox protein Nkx-6.3", "gene_name": "Nkx6-3", "organism": "Mouse", "refseq_name": "homeobox protein Nkx-6.3", "refseq_ac": "NP_083278", "gene_names_uniprotkb": "Nkx6-3", "gene_names_refseq": "9130417I07Rik; Nkx6-3; Nkx6.3", "protein_names_uniprotkb": "Homeobox protein Nkx-6.3", "protein_names_refseq": "NK6 transcription factor related, locus 3; homeobox protein Nkx-6.3", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:74561)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15928328;16297379;16326147;18347062;18586225;20627083;30779550", "class_list": "", "function": "Nkx6.3 function is dispensable for CNS development and lead to the proposal that absence of overt defects is due to functional compensation from a related homeodomain transcription factor., [RefSeq, PubMed]; Nkx6.3 shows a remarkably selective expression in a subpopulation of differentiating V2 neurons at caudal hindbrain levels., [RefSeq, PubMed]; Nkx6.3 transcripts localize in the epithelium of the most distal stomach region, the antrum and pylorus; expression in the adult intestine is lower and confined to the proximal duodenum., [RefSeq, PubMed]; Putative transcription factor, which may be involved in patterning of central nervous system and pancreas., [UniProtKB]; Thus, cross-antagonism between Nkx6 and Ptf1a in multipotent progenitors governs the equilibrium between endocrine and acinar cell neogenesis required for normal pancreas development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4JGN0;Q9D2W8", "ec_number_list": "", "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0002067 glandular epithelial cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3UHX8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4PNJ2-1", "uniprot_id": "NKAI2_MOUSE", "mass": 23895.0, "length": 208, "protein_name": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2", "gene_name": "Nkain2", "organism": "Mouse", "refseq_name": "sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 long isoform", "refseq_ac": "NP_001013429", "gene_names_uniprotkb": "Nkain2; Tcba1", "gene_names_refseq": "6330571D19Rik; Nkain2; Tcba1", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2; Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 2; T-cell lymphoma breakpoint-associated target protein 1", "protein_names_refseq": "Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 2; T-cell lymphoma breakpoint associated target 1; T-cell lymphoma breakpoint-associated target protein 1; sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 long isoform; sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); prostate cancer (Disease Ontology:DOID:10283); cognitive disorder (Disease Ontology:DOID:1561); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (mmu:432450)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;15908570;16145689;17606467;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6MHP5;A6MHP6;A6MHP7;B2RUC0;Q4PNJ3;Q5BLW8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002028 regulation of sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q4PNJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5NCR9-1", "uniprot_id": "NSRP1_MOUSE", "mass": 63799.0, "length": 542, "protein_name": "Nuclear speckle splicing regulatory protein 1", "gene_name": "Nsrp1", "organism": "Mouse", "refseq_name": "nuclear speckle splicing regulatory protein 1", "refseq_ac": "NP_001012309", "gene_names_uniprotkb": "Nsrp1; Ccdc55; Nsrp70", "gene_names_refseq": "8030451K07; Ccdc55; NSpr70; NSrp70; Nsrp1", "protein_names_uniprotkb": "Nuclear speckle splicing regulatory protein 1; Coiled-coil domain-containing protein 55; NSrp70; Nuclear speckle-related protein 70", "protein_names_refseq": "coiled-coil domain containing 55; coiled-coil domain-containing protein 55; nuclear speckle splicing regulatory protein 1; nuclear speckle-related protein 70", "tax_id": 10090, "disease": "", "pathway": " (mmu:237859); (R-MMU-72163)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "17242355;21183079;21296756;21750661;23806337;27802388;28528544;31219806;34037780;34428180;36210013", "class_list": "", "function": "NSrp70 is a lymphocyte-essential splicing factor that controls thymocyte development., [RefSeq, PubMed]; RNA-binding protein that mediates pre-mRNA alternative splicing regulation (By similarity). Through CCDC118 regulation, may promote pre-adipocyte differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:1904179 positive regulation of adipose tissue development;GO:0001701 in utero embryonic development;GO:0006397 mRNA processing;GO:0032502 developmental process;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q5NCR9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61041-1", "uniprot_id": "NPY4R_MOUSE", "mass": 42648.0, "length": 375, "protein_name": "Neuropeptide Y receptor type 4", "gene_name": "Npy4r", "organism": "Mouse", "refseq_name": "neuropeptide Y receptor type 4", "refseq_ac": "NP_032945", "gene_names_uniprotkb": "Npy4r; Ppyr1", "gene_names_refseq": "NPY4-R; NPYR-D; NYYR-D; Npy4r; PP1; Ppyr1; Y4", "protein_names_uniprotkb": "Neuropeptide Y receptor type 4; NPY4-R; NPYR-D; PP1; Pancreatic polypeptide receptor 1", "protein_names_refseq": "Y4 receptor; neuropeptide Y receptor type 4; pancreatic polypeptide receptor 1", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:19065); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "20881101;25445712;26062787;36927661;38554699;8641440", "class_list": "", "function": "Adipocyte reconstitution of Npy4r gene in Npy4r silenced mice promotes diet-induced obesity., [RefSeq, PubMed]; G protein-coupled receptor for PPY/pancreatic polypeptide/PP that is negatively coupled to cAMP (PubMed:8641440). Has much lower affinity for the NPY/neuropeptide Y and PYY/peptide YY (PubMed:8641440)., [UniProtKB, PubMed]; Genetic deletion of the Y4 receptor impaired fear extinction, an effect that was rescued by short-term fasting, [RefSeq, PubMed]; Important role of NPY-Y4R signalling in the dual control of feeding and physical activity., [RefSeq, PubMed]; Taken together, this work demonstrates the critical roles of Y2 and Y4 receptors in the regulation of body composition and energy metabolism, highlighting dual antagonism of Y2 and Y4 receptors as a potentially effective anti-obesity treatment., [RefSeq, PubMed]; These data demonstrate glucose-regulated secretion of PP and its effects on glucagon release through PPYR1 receptors expressed by alpha-cells., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UN46", "ec_number_list": "", "go_molecular_function": "GO:0042277 peptide binding;GO:0001601 peptide YY receptor activity;GO:0001602 pancreatic polypeptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q61041-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61212-1", "uniprot_id": "NPY6R_MOUSE", "mass": 42714.0, "length": 371, "protein_name": "Neuropeptide Y receptor type 6", "gene_name": "Npy6r", "organism": "Mouse", "refseq_name": "neuropeptide Y receptor type 6", "refseq_ac": "NP_035065", "gene_names_uniprotkb": "Npy6r; Npy5r; Ppyr2; Y2b", "gene_names_refseq": "Npy6r", "protein_names_uniprotkb": "Neuropeptide Y receptor type 6; NPY6-R; PP2; Pancreatic polypeptide receptor 2", "protein_names_refseq": "NPY6-R; PP2; neuropeptide Y receptor type 6; pancreatic polypeptide receptor 2", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:18169)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "24411939;26721736;8663568;8910373", "class_list": "", "function": "PP-initiated signaling through Npy6r in vasoactive intestinal peptide neurons regulates the growth hormone axis and body composition., [RefSeq, PubMed]; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY = PYY >= NPY (2-36) = [Leu-31, Pro-34] NPY > NPY (13-36) > PP. The activity of this receptor is mediated by G proteins that inhibits adenylate cyclase activity., [UniProtKB]; Y6R signalling is required for maintenance of bone mass, with loss of y6R uncoupling bone remodelling and resulting in a negative bone balance., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZAW3", "ec_number_list": "", "go_molecular_function": "GO:0008188 neuropeptide receptor activity;GO:0004983 neuropeptide Y receptor activity;GO:0001601 peptide YY receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q61212-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61477-1", "uniprot_id": "NBL1_MOUSE", "mass": 19107.0, "length": 178, "protein_name": "Neuroblastoma suppressor of tumorigenicity 1", "gene_name": "Nbl1", "organism": "Mouse", "refseq_name": "neuroblastoma suppressor of tumorigenicity 1 precursor", "refseq_ac": "NP_032701", "gene_names_uniprotkb": "Nbl1; Dana; Dan", "gene_names_refseq": "D4H1S1733E; DAN; Dana; NO3; Nbl1", "protein_names_uniprotkb": "Neuroblastoma suppressor of tumorigenicity 1; N03; Zinc finger protein DAN", "protein_names_refseq": "N03; neuroblastoma suppressor of tumorigenicity 1 precursor; neuroblastoma suppressor of tumorigenicity 1; neuroblastoma, suppression of tumorigenicity 1; zinc finger protein DAN", "tax_id": 10090, "disease": "", "pathway": " (mmu:17965)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;23063586;30899004;8609050", "class_list": "", "function": "Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q499K5", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0048018 receptor ligand activity;GO:0016015 morphogen activity;GO:0036122 BMP binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0038098 sequestering of BMP from receptor via BMP binding;GO:0090027 negative regulation of monocyte chemotaxis;GO:0007399 nervous system development;GO:0045666 positive regulation of neuron differentiation;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q61477-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62443-1", "uniprot_id": "NPTX1_MOUSE", "mass": 47117.0, "length": 432, "protein_name": "Neuronal pentraxin-1", "gene_name": "Nptx1", "organism": "Mouse", "refseq_name": "neuronal pentraxin-1 precursor", "refseq_ac": "NP_032756", "gene_names_uniprotkb": "Nptx1", "gene_names_refseq": "D11Bwg1004e; Np1; Nptx1", "protein_names_uniprotkb": "Neuronal pentraxin-1; NP-I; NP1; Neuronal pentraxin I", "protein_names_refseq": "NP-I; neuronal pentraxin I; neuronal pentraxin-1 precursor", "tax_id": 10090, "disease": "autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441)", "pathway": " (mmu:18164)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12167713;30084848;30899004;31219806;33300544;33512875;33628204;34098747;34428180;34788392;35291971;8884281", "class_list": "", "function": "BDNF-TrkB signaling-mediated upregulation of Narp is involved in the antidepressant-like effects of (2R,6R)-hydroxynorketamine in a chronic restraint stress mouse model. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses., [UniProtKB, UniProtKB]; Neuronal Pentraxin 1 Promotes Hypoxic-Ischemic Neuronal Injury by Impairing Mitochondrial Biogenesis via Interactions With Active Bax[6A7] and Mitochondrial Hexokinase II., [RefSeq, PubMed]; Neuropathic pain-induced cognitive dysfunction and down-regulation of neuronal pentraxin 2 in the cortex and hippocampus., [RefSeq, PubMed]; The Id3 and NP1 genes become transcriptionally active after MyoD induction in undifferentiated myoblasts. This is a stable, heritable event that does not need continued MyoD activity & is not subject to negative regulation by activated H-Ras G12V., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005783 endoplasmic reticulum;GO:0043083 synaptic cleft;GO:0030133 transport vesicle", "go_biological_process": "GO:0097107 postsynaptic density assembly;GO:0006839 mitochondrial transport;GO:0071333 cellular response to glucose stimulus;GO:0043653 mitochondrial fragmentation involved in apoptotic process;GO:0060385 axonogenesis involved in innervation", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q62443-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TMW6-1", "uniprot_id": "CIAO3_MOUSE", "mass": 53108.0, "length": 476, "protein_name": "Cytosolic iron-sulfur assembly component 3", "gene_name": "Ciao3", "organism": "Mouse", "refseq_name": "cytosolic iron-sulfur assembly component 3", "refseq_ac": "NP_080514", "gene_names_uniprotkb": "Ciao3; Narfl", "gene_names_refseq": "9030612I22Rik; Ciao3; Narfl; PRN", "protein_names_uniprotkb": "Cytosolic iron-sulfur assembly component 3; Cytosolic Fe-S cluster assembly factor NARFL; IOP1; Iron-only hydrogenase-like protein 1; Nuclear prelamin A recognition factor-like protein", "protein_names_refseq": "IOP1; cytosolic Fe-S cluster assembly factor NARFL; cytosolic iron-sulfur assembly component 3; iron-only hydrogenase-like protein 1; nuclear prelamin A recognition factor-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67563)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "18299400;20484733;21367862;21750661;21952136;25428506;25428507;27802388;30084848;30779550;34428180;35820727", "class_list": "", "function": "Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Knock-out of Iop1/Narfl in mice results in lethality and defective cytosolic iron-sulfur cluster assembly. The findings demonstrate an essential role for IOP1 in this pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ULM7;Q8BRR3;Q9CXS6;Q9D320", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0097361 cytosolic [4Fe-4S] assembly targeting complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0001666 response to hypoxia;GO:0010468 regulation of gene expression;GO:0002244 hematopoietic progenitor cell differentiation;GO:0032364 intracellular oxygen homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q7TMW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG30-1", "uniprot_id": "NELFA_MOUSE", "mass": 57585.0, "length": 530, "protein_name": "Negative elongation factor A", "gene_name": "Nelfa", "organism": "Mouse", "refseq_name": "negative elongation factor A isoform 1", "refseq_ac": "NP_036044", "gene_names_uniprotkb": "Nelfa; Whsc2h; Whsc2", "gene_names_refseq": "Nelfa; Whsc2h; Whsc2", "protein_names_uniprotkb": "Negative elongation factor A; NELF-A; Wolf-Hirschhorn syndrome candidate 2 homolog; mWHSC2", "protein_names_refseq": "Wolf-Hirschhorn syndrome candidate 2 homolog; negative elongation factor A isoform 1; negative elongation factor A", "tax_id": 10090, "disease": "", "pathway": " (mmu:24116); (R-MMU-112382); (R-MMU-113418); (R-MMU-674695); (R-MMU-6796648); (R-MMU-75955)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "10409432;20173027;26010750;31932739;32278832;34428180;34678516;37592709", "class_list": "", "function": "Acute NelfA knockdown restricts compensatory gene expression and precipitates ventricular dysfunction during cardiac hypertrophy., [RefSeq, PubMed]; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity)., [UniProtKB, UniProtKB]; Maternal factor NELFA drives a 2C-like state in mouse embryonic stem cells through Dux., [RefSeq, PubMed]; NELFA and BCL2 induce the 2C-like state in mouse embryonic stem cells in a chemically defined medium., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVE4;Q8VEI7;Q9CSJ9;Q9Z1V9", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003682 chromatin binding;GO:0140870 RNA polymerase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0032021 NELF complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0031401 positive regulation of protein modification process;GO:0034244 negative regulation of transcription elongation by RNA polymerase II;GO:0160239 transcription pausing by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BG30-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BH82-1", "uniprot_id": "NAPEP_MOUSE", "mass": 45816.0, "length": 396, "protein_name": "N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D", "gene_name": "Napepld", "organism": "Mouse", "refseq_name": "N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform b", "refseq_ac": "NP_848843", "gene_names_uniprotkb": "Napepld; Mbldc1", "gene_names_refseq": "A530089G06; Mbldc1; NAPE-PLD; Napepld", "protein_names_uniprotkb": "N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; 3.1.4.54; N-acyl phosphatidylethanolamine phospholipase D; NAPE-PLD; NAPE-hydrolyzing phospholipase D", "protein_names_refseq": "Metallo-beta-lactamase domain containing 1; N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform b; N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; NAPE-hydrolyzing phospholipase D", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); osteoarthritis (Disease Ontology:DOID:8398); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:242864)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14634025;15760304;16605240;16818490;17655883;21801852;25757720;30084848;30779550;31685899;32776827;33706934;34428180", "class_list": "", "function": "D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (PubMed:14634025, PubMed:15760304, PubMed:17655883, PubMed:21801852). Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (PubMed:16605240, PubMed:21801852). May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (PubMed:31685899). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose (PubMed:25757720). Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (PubMed:14634025)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids., [RefSeq, PubMed]; Intestinal NAPE-PLD contributes to short-term regulation of food intake via gut-to-brain axis., [RefSeq, PubMed]; NAPE-specific phospholipase D regulates LRRK2 association with neuronal membranes., [RefSeq, PubMed]; Results confirm that overexpressed NAPE-PLD is capable of forming NAEs, including anandamide, in living cells, [RefSeq, PubMed]; Results support the existence of an N-acyl phosphatidylethanolamine (NAPE)-phospholipase D-independent route for N-acyl ethanolamine (NAE) biosynthesis and suggest that Abh4 plays a role in this pathway by acting as a (lyso)NAPE-selective lipase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.54;3.1.4.-", "go_molecular_function": "GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0004620 phospholipase activity;GO:0032052 bile acid binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome", "go_biological_process": "GO:0070291 N-acylethanolamine metabolic process;GO:1903999 negative regulation of eating behavior;GO:0001659 temperature homeostasis;GO:0009395 phospholipid catabolic process;GO:0050729 positive regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BH82-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHY2-1", "uniprot_id": "NOC4L_MOUSE", "mass": 58676.0, "length": 516, "protein_name": "Nucleolar complex protein 4 homolog", "gene_name": "Noc4l", "organism": "Mouse", "refseq_name": "nucleolar complex protein 4 homolog", "refseq_ac": "NP_705798", "gene_names_uniprotkb": "Noc4l", "gene_names_refseq": "Noc4l", "protein_names_uniprotkb": "Nucleolar complex protein 4 homolog; NOC4 protein homolog; NOC4-like protein; Nucleolar complex-associated protein 4-like protein", "protein_names_refseq": "NOC4 protein homolog; NOC4-like protein; nucleolar complex associated 4 homolog; nucleolar complex protein 4 homolog; nucleolar complex-associated protein 4-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:100608); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "31018134;31219806;34675215;34887587", "class_list": "", "function": "Genetic ablation of Noc4L in Regulatory T cells results in a Severe Autoimmune Disease., [RefSeq, PubMed]; Macrophage deletion of Noc4l triggers endosomal TLR4/TRIF signal and leads to insulin resistance. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1F7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0031965 nuclear membrane;GO:0030692 Noc4p-Nop14p complex;GO:0032040 small-subunit processome", "go_biological_process": "GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BHY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BR37-1", "uniprot_id": "NHLC1_MOUSE", "mass": 42690.0, "length": 401, "protein_name": "E3 ubiquitin-protein ligase NHLRC1", "gene_name": "Nhlrc1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase NHLRC1", "refseq_ac": "NP_780549", "gene_names_uniprotkb": "Nhlrc1; Epm2b", "gene_names_refseq": "B230309E09Rik; EPM2B; Nhlrc1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase NHLRC1; 2.3.2.27; Malin; NHL repeat-containing protein 1; RING-type E3 ubiquitin transferase NHLRC1", "protein_names_refseq": "E3 ubiquitin-protein ligase NHLRC1; NHL repeat-containing protein 1; RING-type E3 ubiquitin transferase NHLRC1; malin", "tax_id": 10090, "disease": "Lafora disease 2 (Disease Ontology:DOID:0061211); Lafora disease (Disease Ontology:DOID:3534)", "pathway": " (mmu:105193)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12958597;19036738;19529779;21077101;22186026;22669944;25428506;36511140", "class_list": "", "function": "E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Laforin and malin play a role protecting cells from ER-stress, likely contributing to the elimination of unfolded proteins Publication Status: Online-Only, [RefSeq, PubMed]; Laforin targets malin to glycogen in Lafora progressive myoclonus epilepsy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006914 autophagy;GO:0031398 positive regulation of protein ubiquitination;GO:0005978 glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BR37-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZR9-1", "uniprot_id": "NCBP3_MOUSE", "mass": 70043.0, "length": 615, "protein_name": "Nuclear cap-binding protein subunit 3", "gene_name": "Ncbp3", "organism": "Mouse", "refseq_name": "nuclear cap-binding protein subunit 3", "refseq_ac": "NP_080094", "gene_names_uniprotkb": "Ncbp3", "gene_names_refseq": "1200014J11Rik; C130061O14Rik; Ncbp3", "protein_names_uniprotkb": "Nuclear cap-binding protein subunit 3", "protein_names_refseq": "nuclear cap-binding protein subunit 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:66874)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;25428506;26382858;30059200;31219806", "class_list": "", "function": "Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858)., [UniProtKB, PubMed]; Study proposes the existence of an alternative cap-binding complex involving NCBP1 and NCBP3 that plays a key role in mRNA biogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNF4;Q3TQ96;Q4G0C3;Q8BMB1;Q9CRM6;Q9CS93;Q9D0G9;Q9DBT0", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0000339 RNA cap binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005846 nuclear cap binding complex", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0051607 defense response to virus;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:0042789 mRNA transcription by RNA polymerase II;GO:0006370 7-methylguanosine mRNA capping", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BZR9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C261-1", "uniprot_id": "NCKX5_MOUSE", "mass": 54984.0, "length": 501, "protein_name": "Sodium/potassium/calcium exchanger 5", "gene_name": "Slc24a5", "organism": "Mouse", "refseq_name": "sodium/potassium/calcium exchanger 5 precursor", "refseq_ac": "NP_778199", "gene_names_uniprotkb": "Slc24a5; Nckx5", "gene_names_refseq": "F630045L20Rik; JSX; NCKX5; NCX5; Oca6; Slc24a5", "protein_names_uniprotkb": "Sodium/potassium/calcium exchanger 5; Na(+)/K(+)/Ca(2+)-exchange protein 5; Solute carrier family 24 member 5", "protein_names_refseq": "K-independent Na+/Ca2+ exchanger JSX; Na(+)/K(+)/Ca(2+)-exchange protein 5; Na-Ca exchanger 5; sodium/potassion/calcium exchanger 5; sodium/potassium/calcium exchanger 5 precursor; sodium/potassium/calcium exchanger 5", "tax_id": 10090, "disease": "ocular albinism 1 (Disease Ontology:DOID:0050633); oculocutaneous albinism type VI (Disease Ontology:DOID:0080614)", "pathway": " (mmu:317750); (R-MMU-425561)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16357253;18166528;18424845;22677781;30084848;31201282", "class_list": "", "function": "Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes., [UniProtKB, UniProtKB]; Mutation of Slc24a5 results in marked hypopigmentation of melanosomes in optic cup-derived pigmented epithelium in the eyes., [RefSeq, PubMed]; NCKX5 is localized to mitochondria, not to melanosomes. Publication Status: Online-Only, [RefSeq, PubMed]; Non-synonymous single nucleotide polymorphism in SLC24A5 alters a residue that is important for NCKX5 and NCKX2 activity, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6XE39;Q8CJF1", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0015293 symporter activity;GO:0008273 calcium, potassium:sodium antiporter activity;GO:0015085 calcium ion transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0042470 melanosome;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0048022 negative regulation of melanin biosynthetic process;GO:0006874 intracellular calcium ion homeostasis;GO:0034220 monoatomic ion transmembrane transport;GO:0070588 calcium ion transmembrane transport;GO:0070509 calcium ion import", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C261-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C4W3-1", "uniprot_id": "NRN1L_MOUSE", "mass": 17390.0, "length": 162, "protein_name": "Neuritin-like protein", "gene_name": "Nrn1l", "organism": "Mouse", "refseq_name": "neuritin-like protein isoform 2 precursor", "refseq_ac": "NP_001288103", "gene_names_uniprotkb": "Nrn1l; Cpg15-2", "gene_names_refseq": "Cpg15-2; G630049C14Rik; Nrn1l", "protein_names_uniprotkb": "Neuritin-like protein; Candidate plasticity gene 15-2 protein", "protein_names_refseq": "MRCC2446-like protein; candidate plasticity gene 15-2 protein; neuritin-like protein isoform 2 precursor; neuritin-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:234700); (R-MMU-163125)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "18265009", "class_list": "", "function": "CPG15 and CPG15-2 perform similar cellular functions but may play distinct roles in vivo through their cell-type- and tissue-specific transcriptional regulation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BN06", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0098552 side of membrane", "go_biological_process": "GO:1990138 neuron projection extension", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C4W3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C5P5-1", "uniprot_id": "NT5D1_MOUSE", "mass": 53094.0, "length": 467, "protein_name": "5'-nucleotidase domain-containing protein 1", "gene_name": "Nt5dc1", "organism": "Mouse", "refseq_name": "5'-nucleotidase domain-containing protein 1 isoform 2", "refseq_ac": "NP_001334392", "gene_names_uniprotkb": "Nt5dc1; Nt5c2l1", "gene_names_refseq": "6030401B09Rik; Nt5c2l1; Nt5dc1", "protein_names_uniprotkb": "5'-nucleotidase domain-containing protein 1; 3.1.3.-; Cytosolic 5'-nucleotidase II-like protein 1", "protein_names_refseq": "5'-nucleotidase domain-containing protein 1 isoform 2; 5'-nucleotidase domain-containing protein 1; 5'-nucleotidase, cytosolic II-like 1; cytosolic 5'-nucleotidase II-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:319638)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16672222;21750661;34428180", "class_list": "", "function": "Inhibited by lead which binds at the active site and my inhibit lead poisoning., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAL3;Q3TPT8;Q3TTI3;Q3UL73;Q4G0D1", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008253 5'-nucleotidase activity;GO:0016787 hydrolase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C5P5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHT1-1", "uniprot_id": "NGEF_MOUSE", "mass": 82199.0, "length": 710, "protein_name": "Ephexin-1", "gene_name": "Ngef", "organism": "Mouse", "refseq_name": "ephexin-1 isoform 1", "refseq_ac": "NP_001104784", "gene_names_uniprotkb": "Ngef", "gene_names_refseq": "Ngef; Tims2; ephexin", "protein_names_uniprotkb": "Ephexin-1; Eph-interacting exchange protein; Neuronal guanine nucleotide exchange factor", "protein_names_refseq": "eph-interacting exchange protein; ephexin-1 isoform 1; ephexin-1; transforming immortalised mammary epithelial sequence 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:53972); (R-MMU-193648); (R-MMU-3928663); (R-MMU-416482); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 7, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10777665;11336673;15142957;15254079;15848799;17114649;17143272;21750661;28769056;29363583;33300544", "class_list": "", "function": "Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; These findings suggest that increased EphA4-ephexin1 signaling in the PFC plays a role in the pathophysiology of depression. Erratum:[Sci Rep. 2023 May 17;13(1):8059. doi: 10.1038/s41598-023-34971-6. PMID: 37198278] Publication Status: Online-Only, [RefSeq, PubMed]; We found ephexin1 essential for the development of limb nerves toward their muscle targets, concluding that it functions as an intermediary to relay Eph signaling in this context, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8R204;Q923H2;Q9JHT9", "ec_number_list": "", "go_molecular_function": "GO:0046875 ephrin receptor binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0016020 membrane;GO:0030426 growth cone;GO:0098794 postsynapse", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0032956 regulation of actin cytoskeleton organization;GO:0043087 regulation of GTPase activity;GO:0048013 ephrin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8CHT1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCE6-1", "uniprot_id": "NT5M_MOUSE", "mass": 25602.0, "length": 220, "protein_name": "5'(3')-deoxyribonucleotidase, mitochondrial", "gene_name": "Nt5m", "organism": "Mouse", "refseq_name": "5'(3')-deoxyribonucleotidase, mitochondrial isoform 1 precursor", "refseq_ac": "NP_598790", "gene_names_uniprotkb": "Nt5m; Dnt2", "gene_names_refseq": "2010013E09Rik; Nt5m; dNT-2", "protein_names_uniprotkb": "5'(3')-deoxyribonucleotidase, mitochondrial; 3.1.3.-; 5',3'-nucleotidase, mitochondrial; Deoxy-5'-nucleotidase 2; dNT-2", "protein_names_refseq": "5'(3')-deoxyribonucleotidase, mitochondrial isoform 1 precursor; 5'(3')-deoxyribonucleotidase, mitochondrial; deoxy-5'-nucleotidase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:103850); (R-MMU-73621)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12234672", "class_list": "glycogene", "function": "Dephosphorylates preferentially the 5'- and 2'(3')-phosphates of uracil and thymine (deoxy)ribonucleotide monophosphates (PubMed:12234672). Has low activity towards dGMP and marginal activity towards dIMP (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 12, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.5;2.7.1.77;3.1.3.99;3.1.3.91;3.1.3.89;3.1.3.35;3.1.3.-", "go_molecular_function": "GO:0008254 3'-nucleotidase activity;GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0008253 5'-nucleotidase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0046079 dUMP catabolic process;GO:0009223 pyrimidine deoxyribonucleotide catabolic process;GO:0046038 GMP catabolic process;GO:0046050 UMP catabolic process;GO:0046074 dTMP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VCE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VI84-1", "uniprot_id": "NOC3L_MOUSE", "mass": 93211.0, "length": 807, "protein_name": "Nucleolar complex protein 3 homolog", "gene_name": "Noc3l", "organism": "Mouse", "refseq_name": "nucleolar complex protein 3 homolog", "refseq_ac": "NP_067290", "gene_names_uniprotkb": "Noc3l; Ad24; Fad24", "gene_names_refseq": "Fad24; Noc3l", "protein_names_uniprotkb": "Nucleolar complex protein 3 homolog; Factor for adipocyte differentiation 24; NOC3 protein homolog; NOC3-like protein; Nucleolar complex-associated protein 3-like protein", "protein_names_refseq": "NOC3 protein homolog; NOC3-like protein; factor for adipocyte differentiation 24; nucleolar complex associated 3 homolog; nucleolar complex protein 3 homolog; nucleolar complex-associated protein 3-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:57753)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11146508;15564382;18029353;18284919;23886952;25428506;26902224;27040346;31219806;34203471;34428180", "class_list": "", "function": "FAD24 controls DNA replication by recruiting HBO1 to origins of DNA replication and is required for MCE during adipocyte differentiation., [RefSeq, PubMed]; Fad24 is essential for pre-implantation in embryonic development, particularly for the progression to the blastocyst stage, [RefSeq, PubMed]; Fad24 may have an important role in the S phase re-entry of quiescent C2C12 cells through the regulation of p27(Kip1) at the protein level, [RefSeq, PubMed]; Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation, [RefSeq, PubMed]; It contributes not only to adipogenesis but also to other physiological events like pre-implantation in embryonic developments. Review article, [RefSeq, PubMed]; May be required for adipogenesis., [UniProtKB, PubMed]; Taken together, these results reveal a novel role for fad24 in the repression of NF-kappaB activity and H-ras-mediated transformation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QQ46;Q9JKM3", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0016607 nuclear speck", "go_biological_process": "GO:0045444 fat cell differentiation;GO:0006270 DNA replication initiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8VI84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99J85-1", "uniprot_id": "NPTXR_MOUSE", "mass": 52285.0, "length": 493, "protein_name": "Neuronal pentraxin receptor", "gene_name": "Nptxr", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nptxr; Npr", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuronal pentraxin receptor", "protein_names_refseq": "", "tax_id": 10090, "disease": "brain ischemia (Disease Ontology:DOID:2316); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:73340)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21549840;21750661;30899004;31219806;34428180;40885482", "class_list": "", "function": "May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0019903 protein phosphatase binding;GO:0008029 pentraxin receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0031175 neuron projection development;GO:0099150 regulation of postsynaptic specialization assembly;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q99J85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LJ8-1", "uniprot_id": "NGBR_MOUSE", "mass": 33485.0, "length": 297, "protein_name": "Dehydrodolichyl diphosphate synthase complex subunit Nus1", "gene_name": "Nus1", "organism": "Mouse", "refseq_name": "dehydrodolichyl diphosphate synthase complex subunit Nus1", "refseq_ac": "NP_084526", "gene_names_uniprotkb": "Nus1; D10Ertd438e; Ngbr", "gene_names_refseq": "1600027K07Rik; D10Ertd438e; Nus1", "protein_names_uniprotkb": "Dehydrodolichyl diphosphate synthase complex subunit Nus1; 2.5.1.87; NgBR; Nogo-B receptor; Nuclear undecaprenyl pyrophosphate synthase 1 homolog", "protein_names_refseq": "Nogo-B receptor; dehydrodolichyl diphosphate syntase complex subunit Nus1; dehydrodolichyl diphosphate synthase complex subunit Nus1; di-trans,poly-cis-decaprenylcistransferase; ngBR; nuclear undecaprenyl pyrophosphate synthase 1 homolog", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 55 (Disease Ontology:DOID:0080227); congenital disorder of glycosylation Iaa (Disease Ontology:DOID:0080553); Parkinson's disease (Disease Ontology:DOID:14330); epilepsy (Disease Ontology:DOID:1826); congenital disorder of glycosylation (Disease Ontology:DOID:5212)", "pathway": " (mmu:52014); (R-MMU-446199)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16835300;17585875;25066056;26755743;36996002", "class_list": "", "function": "Identify a previously uncharacterized Nogo-B receptor specific for the amino terminus of Nogo-B., [RefSeq, PubMed]; Loss of Nogo-B receptor in mice causes early embryonic lethality and defects in glycosylation., [RefSeq, PubMed]; Our results indicate that the NgBR ectodomain is intrinsically unstructured without tertiary structures while the cytoplasmic domain is partially folded with secondary structures but without a tight tertiary packing [nogo-b receptor], [RefSeq, PubMed]; Overexpression of NgBR inhibits high-fat diet-induced atherosclerosis in ApoE-deficiency mice. Publication Status: Online-Only, [RefSeq, PubMed]; With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery (PubMed:25066056). Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (By similarity). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (By similarity). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (By similarity). Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0P6D7;Q3TIA3;Q3TIR7;Q3U1Z4", "ec_number_list": "2.5.1.87;2.5.1.-", "go_molecular_function": "GO:0004659 prenyltransferase activity;GO:0045547 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:1904423 dehydrodolichyl diphosphate synthase complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0030154 cell differentiation;GO:0032383 regulation of intracellular cholesterol transport;GO:0042632 cholesterol homeostasis;GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99LJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPP0-1", "uniprot_id": "NPM3_MOUSE", "mass": 19023.0, "length": 175, "protein_name": "Nucleoplasmin-3", "gene_name": "Npm3", "organism": "Mouse", "refseq_name": "nucleoplasmin-3", "refseq_ac": "NP_032749", "gene_names_uniprotkb": "Npm3", "gene_names_refseq": "Npm3; Nub1", "protein_names_uniprotkb": "Nucleoplasmin-3", "protein_names_refseq": "nucleoplasmin-3", "tax_id": 10090, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:18150)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15596447;21183079;21540332;25153642;28135057;28366643;28528544;31219806;9177783", "class_list": "", "function": "Overexpression of a mutant of NPM3 that did not interact with B23 did not alter pre-rRNA synthesis and processing, suggesting that the interaction of NPM3 with B23 plays a role in the ribosome biogenesis, [RefSeq, PubMed]; Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning. Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM. Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJ58", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0009303 rRNA transcription;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CPP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CRA0-1", "uniprot_id": "NAR4_MOUSE", "mass": 33080.0, "length": 300, "protein_name": "Ecto-ADP-ribosyltransferase 4", "gene_name": "Art4", "organism": "Mouse", "refseq_name": "ecto-ADP-ribosyltransferase 4 precursor", "refseq_ac": "NP_080915", "gene_names_uniprotkb": "Art4", "gene_names_refseq": "4432404K01Rik; ARTC4; Art4; DOK1; DO", "protein_names_uniprotkb": "Ecto-ADP-ribosyltransferase 4; 2.4.2.31; ADP-ribosyltransferase C2 and C3 toxin-like 4; ARTC4; Mono(ADP-ribosyl)transferase 4; NAD(P)(+)--arginine ADP-ribosyltransferase 4", "protein_names_refseq": "ADP-ribosyltransferase C2 and C3 toxin-like 4; NAD(P)(+)--arginine ADP-ribosyltransferase 4; ecto-ADP-ribosyltransferase 4 precursor; ecto-ADP-ribosyltransferase 4; mono(ADP-ribosyl)transferase 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:109978); (R-MMU-163125)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12070318;37507081", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q80VB5;Q80W56", "ec_number_list": "3.4.11.9;3.1.3.1;3.2.2.5;2.4.2.31;3.1.4.50;3.9.1.1;2.4.2.-;2.3.1.-;2.3.1.286;3.2.2.6;3.4.17.12;3.4.21.-;3.5.1.92", "go_molecular_function": "GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0106274 NAD+-protein-arginine ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CRA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0F4-1", "uniprot_id": "NKAP_MOUSE", "mass": 47227.0, "length": 415, "protein_name": "NF-kappa-B-activating protein", "gene_name": "Nkap", "organism": "Mouse", "refseq_name": "NF-kappa-B-activating protein", "refseq_ac": "NP_080213", "gene_names_uniprotkb": "Nkap", "gene_names_refseq": "2610020O08Rik; Nkap", "protein_names_uniprotkb": "NF-kappa-B-activating protein", "protein_names_refseq": "NF-kappa-B-activating protein; nuclear NF-kappaB activating protein", "tax_id": 10090, "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); carcinoma (Disease Ontology:DOID:305)", "pathway": " (mmu:67050); (R-MMU-72163)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14550261;19409814;20610818;21624937;23481390;29366602;30804042;31175160;31219806;31387873", "class_list": "", "function": "Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter (By similarity)., [UniProtKB, UniProtKB]; Inducible deletion of NKAP in adult mice leads to lethality within 2 weeks, at which point hematopoiesis in the bone marrow has halted and hematopoietic stem cells have disappeared., [RefSeq, PubMed]; NKAP functions as a transcriptional repressor, acting on Notch target genes, and is required for alphabeta T cell development., [RefSeq, PubMed]; NKAP is a novel nuclear regulator of TNF- and IL-1-induced NF-kappaB activation, [RefSeq, PubMed]; NKAP is required for T cell maturation and the acquisition of functional competency, [RefSeq, PubMed]; NKAP-deficient immature peripheral T cells remain scarce in complement-deficient mice likely due to ferroptosis., [RefSeq, PubMed]; These results demonstrate the significance of NKAP-HDAC3 association in T cells. Publication Status: Online-Only, [RefSeq, PubMed]; This study shows that Treg-specific deletion of NKAP results in severe, systemic autoimmunity due to peripheral loss of Tregs, [RefSeq, PubMed]; Transcriptional repressor NKAP is required for invariant natural killer T cell but not conventional T cell development., [RefSeq, PubMed]; Y352 in NKAP is critical for association with HDAC3 and for HSC maintenance and survival but is not important for proliferation of murine embryonic fibroblasts, demonstrating that NKAP functions in different complexes in different cell types., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTK6;Q8BYT5;Q8R324;Q9CSH4", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0071007 U2-type catalytic step 2 spliceosome", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D0F4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7Z3-1", "uniprot_id": "UTP16_MOUSE", "mass": 28970.0, "length": 254, "protein_name": "U3 small nucleolar RNA-associated protein NOL7", "gene_name": "Nol7", "organism": "Mouse", "refseq_name": "U3 small nucleolar RNA-associated protein NOL7", "refseq_ac": "NP_076043", "gene_names_uniprotkb": "Nol7; MNCb-1192", "gene_names_refseq": "2210008F15Rik; 5730556I21Rik; NOP27; Nol7; RARG-1", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein NOL7; Nucleolar protein 7; U3 snoRNA-associated protein NOL7", "protein_names_refseq": "U3 small nucleolar RNA-associated protein NOL7; U3 snoRNA-associated protein NOL7", "tax_id": 10090, "disease": "", "pathway": " (mmu:70078)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17242355;19131326;21183079;21750661;31219806", "class_list": "", "function": "Functions as part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit that coordinates the first two steps of ribosome biogenesis in transcription of the primary transcript pre-RNA and pre-18S processing. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. This subunit is required for processing of the 5'-external transcribed spacer sequence (5'ETS) of the primary transcript pre-rRNA to yield the 18S rRNA. Also plays a role in maintaining early pre-rRNA levels, either by assisting in its transcription or stability., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CY79;Q9JJE2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005694 chromosome;GO:0032040 small-subunit processome;GO:0005634 nucleus", "go_biological_process": "GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D7Z3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB96-1", "uniprot_id": "NGDN_MOUSE", "mass": 35659.0, "length": 315, "protein_name": "Neuroguidin", "gene_name": "Ngdn", "organism": "Mouse", "refseq_name": "neuroguidin", "refseq_ac": "NP_081166", "gene_names_uniprotkb": "Ngdn; Ngd", "gene_names_refseq": "1500001L15Rik; Ngdn; Ngd; neuroguidin", "protein_names_uniprotkb": "Neuroguidin; EIF4E-binding protein", "protein_names_refseq": "EIF4E-binding protein; neuroguidin", "tax_id": 10090, "disease": "", "pathway": " (mmu:68966)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16705177;22727665;30084848;31219806;34428180", "class_list": "", "function": "A new eukaryotic initiation factor 4E (eIF4E) binding protein, Neuroguidin (Ngd), and its interaction with CPEB is described., [RefSeq, PubMed]; Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1* (By similarity). Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner (PubMed:16705177)., [UniProtKB, UniProtKB, PubMed]; Poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) are components of a dendritic CPEB-associated polyadenylation apparatus, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIJ2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0030424 axon", "go_biological_process": "GO:1903077 negative regulation of protein localization to plasma membrane;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis;GO:0099170 postsynaptic modulation of chemical synaptic transmission;GO:0140245 regulation of translation at postsynapse", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DB96-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DC70-1", "uniprot_id": "NDUS7_MOUSE", "mass": 24683.0, "length": 224, "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "gene_name": "Ndufs7", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform 1 precursor", "refseq_ac": "NP_083548", "gene_names_uniprotkb": "Ndufs7", "gene_names_refseq": "1010001M04Rik; CI-20kD; Ndufs7", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; 7.1.1.2; CI-20kD; Complex I-20kD; NADH-ubiquinone oxidoreductase 20 kDa subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) Fe-S protein 7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform 1 precursor; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; NADH-ubiquinone oxidoreductase 20 kDa subunit; complex I-20kD", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); nuclear type mitochondrial complex I deficiency 3 (Disease Ontology:DOID:0112093); bipolar disorder (Disease Ontology:DOID:3312)", "pathway": " (mmu:75406); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "16452087;21183079;25605945;31219806;33300544;34428180;36288343;37453647;38575788", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.-;1.-.-.-;7.1.1.2;3.6.4.10;1.3.8.7;1.3.8.8;2.1.1.320", "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0002020 protease binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0043025 neuronal cell body;GO:0097060 synaptic membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration;GO:0015990 electron transport coupled proton transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9DC70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCJ9-1", "uniprot_id": "NPL_MOUSE", "mass": 35130.0, "length": 320, "protein_name": "N-acetylneuraminate lyase", "gene_name": "Npl", "organism": "Mouse", "refseq_name": "N-acetylneuraminate lyase", "refseq_ac": "NP_083025", "gene_names_uniprotkb": "Npl", "gene_names_refseq": "0610033B02Rik; Npl", "protein_names_uniprotkb": "N-acetylneuraminate lyase; 4.1.3.3; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; NALase; Sialate lyase; Sialate-pyruvate lyase; Sialic acid aldolase; Sialic acid lyase", "protein_names_refseq": "N-acetylneuraminate lyase; N-acetylneuraminic acid aldolase; NALase; sialate lyase; sialate-pyruvate lyase; sialic acid aldolase; sialic acid lyase", "tax_id": 10090, "disease": "myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:74091); (R-MMU-4085001)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21183079;22692205;23741500;37390204", "class_list": "glycogene", "function": "Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway., [UniProtKB, PubMed]; N-acetylneuraminate pyruvate lyase controls sialylation of muscle glycoproteins essential for muscle regeneration and function., [RefSeq, PubMed]; This study demonstrates PR-mediated dynamic expression of Npl in the periimplantation uterus and dispensable role of Npl in uterine function and embryo development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.1.3.3", "go_molecular_function": "GO:0042802 identical protein binding;GO:0008747 N-acetylneuraminate lyase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019262 N-acetylneuraminate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DCJ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQM3-1", "uniprot_id": "NKX24_MOUSE", "mass": 36225.0, "length": 354, "protein_name": "Homeobox protein Nkx-2.4", "gene_name": "Nkx2-4", "organism": "Mouse", "refseq_name": "homeobox protein Nkx-2.4", "refseq_ac": "NP_075993", "gene_names_uniprotkb": "Nkx2-4; Nkx2d", "gene_names_refseq": "1700001P03Rik; Nkx-2.4; Nkx2-4; tinman", "protein_names_uniprotkb": "Homeobox protein Nkx-2.4; Homeobox protein NK-2 homolog D", "protein_names_refseq": "NK2 transcription factor related, locus 4; homeobox protein NK-2 homolog D; homeobox protein Nkx-2.4", "tax_id": 10090, "disease": "", "pathway": " (mmu:228731)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10818213;1346742", "class_list": "", "function": "Probable transcription factor., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2ATK2;Q9EQM4", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9EQM3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJR9-1", "uniprot_id": "NRIP3_MOUSE", "mass": 26879.0, "length": 240, "protein_name": "Nuclear receptor-interacting protein 3", "gene_name": "Nrip3", "organism": "Mouse", "refseq_name": "nuclear receptor-interacting protein 3", "refseq_ac": "NP_065635", "gene_names_uniprotkb": "Nrip3; D7H11orf14", "gene_names_refseq": "A330103B05Rik; D7H11orf14; ICRFP703B1614Q5.2; Nrip3", "protein_names_uniprotkb": "Nuclear receptor-interacting protein 3", "protein_names_refseq": "ICRFP703N2430Q5.2; nuclear receptor-interacting protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:78593)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11528127;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUN8", "ec_number_list": "", "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JJR9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXK8-1", "uniprot_id": "NMU_MOUSE", "mass": 19429.0, "length": 174, "protein_name": "Neuromedin-U", "gene_name": "Nmu", "organism": "Mouse", "refseq_name": "neuromedin-U precursor", "refseq_ac": "NP_062388", "gene_names_uniprotkb": "Nmu", "gene_names_refseq": "Nmu", "protein_names_uniprotkb": "Neuromedin-U; Prepro-NMU", "protein_names_refseq": "neuromedin U precursor-related peptide/neuromedin U preproprotein; neuromedin-U precursor", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:56183); (R-MMU-375276); (R-MMU-416476); (R-MMU-418594)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "14622096;15369794;15448684;28874765;33857254;37708282;38071753", "class_list": "", "function": "Analysis of NMU expression in ob/ob mice revealed elevated NMU mRNA levels in the dorsomedial hypothalamic (DMH) nucleus of ob/ob mice compared to lean litter-mates. NMU mRNA levels were elevated in the DMH of mice fasted for 24 h relative to controls, [RefSeq, PubMed]; Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36., [UniProtKB, UniProtKB]; Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system., [UniProtKB, UniProtKB]; Multifunctional neuropeptide that acts via two G protein-coupled receptors, NMUR1 and NMUR2 (By similarity). Functionally, is involved in pleiotropic roles, including regulation of feeding, energy balance, blood pressure and smooth muscle contraction (By similarity). Additionally modulates hormone release and inflammatory responses in a tissue- and receptor-dependent manner (PubMed:33857254). Mechanistically, binding to NMUR1 or NMUR2 results in coupling of receptors to Galpha proteins, namely GNAQ/Gaq or GNA11/Ga11 and GNAI1/Gai subunits. GNAQ/Gaq or GNA11/Ga11 coupling leads to the activation of a phospholipase C (PLC), which hydrolyzes PIP2 (phosphatidylinositol 4,5-bisphosphate) into DAG (diacylglycerol) and IP3 (inositol trisphosphate), and subsequent intracellular calcium mobilization via IP3 receptors on the endoplasmic reticulum. GNAI1/Gai coupling inhibits forskolin-stimulated cAMP accumulation (By similarity). In pancreatic beta cells, regulates insulin secretion through NMUR1 coupled to GNAI2 and GNAO1, resulting in reduced intracellular Ca2+ influx and cAMP levels (PubMed:33857254). Through NMUR1 in Th2-type T cells, enhances type 2 cytokine secretion and modulates inflammatory responses via activation of PLC-calcineurin-MEK and PI3K signaling pathways (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; NMU plays an important role in the regulation of feeding behavior and energy metabolism independent of the leptin signaling pathway., [RefSeq, PubMed]; Neuromedin U programs eosinophils to promote mucosal immunity of the small intestine., [RefSeq, PubMed]; Neuromedin U regulates the anti-tumor activity of CD8[+] T cells and glycolysis of tumor cells in the tumor microenvironment of pancreatic ductal adenocarcinoma in an NMUR1-dependent manner., [RefSeq, PubMed]; Results suggest that endogenous NMU may be involved in reflexes and adaptation to environmental stimuli, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q059S5", "ec_number_list": "", "go_molecular_function": "GO:0042922 neuromedin U receptor binding;GO:0031839 type 1 neuromedin U receptor binding;GO:0031840 type 2 neuromedin U receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0043195 terminal bouton", "go_biological_process": "GO:1903999 negative regulation of eating behavior;GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:2000252 negative regulation of feeding behavior;GO:0060455 negative regulation of gastric acid secretion;GO:0001659 temperature homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QXK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18894-1", "uniprot_id": "OXDA_MOUSE", "mass": 38652.0, "length": 345, "protein_name": "D-amino-acid oxidase", "gene_name": "Dao", "organism": "Mouse", "refseq_name": "D-amino-acid oxidase isoform 1", "refseq_ac": "NP_001273325", "gene_names_uniprotkb": "Dao; Dao1", "gene_names_refseq": "DAAO; DAMOX; Dao-1; Dao1; Dao", "protein_names_uniprotkb": "D-amino-acid oxidase; 1.4.3.3; DAAO; DAMOX; DAO", "protein_names_refseq": "D-amino acid oxidase 1; D-amino-acid oxidase isoform 1", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:13142); (R-MMU-389661); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 42, "publication_id_list": "11114476;11419736;1346751;1355365;15996778;16141519;16843004;1686595;17042912;17874293;18940194;19117914;19751394;1976103;20564560;20567862;20603179;21750661;22203986;22271930;24194108;25425233;25816902;26833794;27670111;2895696;2904113;2904279;2906843;29194436;29532193;30938755;31309542;33484270;35915065;36429117;37289348;6147398;7901999;7903300;8100053;9133654", "class_list": "", "function": "Catalyzes the oxidative deamination of D-amino acids with broad substrate specificity (PubMed:11419736, PubMed:1346751, PubMed:1355365, PubMed:16141519, PubMed:17042912, PubMed:20567862, PubMed:20603179, PubMed:24194108, PubMed:33484270, PubMed:8100053, Ref.36). Required to catabolize D-amino acids synthesized endogenously, of gastrointestinal bacterial origin or obtained from the diet, and to use these as nutrients (PubMed:24194108, PubMed:27670111, PubMed:6147398, PubMed:7901999, Ref.33, Ref.36). Regulates the level of D-amino acid neurotransmitters in the brain, such as D-serine, a co-agonist of N-methyl D-aspartate (NMDA) receptors, and may modulate synaptic transmission (PubMed:11419736, PubMed:29532193, PubMed:8100053). Catalyzes the first step of the racemization of D-DOPA to L-DOPA, for possible use in an alternative dopamine biosynthesis pathway (PubMed:17042912). Also catalyzes the first step of the chiral inversion of N(gamma)-nitro-D-arginine methyl ester (D-NNA) to its L-enantiomer L-NNA that acts as a nitric oxide synthase inhibitor (PubMed:20564560). The hydrogen peroxide produced in the reaction provides protection against microbial infection; it contributes to the oxidative killing activity of phagocytic leukocytes and protects against bacterial colonization of the small intestine (PubMed:22271930, PubMed:25425233, PubMed:27670111). Enzyme secreted into the lumen of the intestine may not be catalytically active and could instead be proteolytically cleaved into peptides with antimicrobial activity (PubMed:33484270). The hydrogen peroxide produced in the reaction may also play a role in promoting cellular senescence in response to DNA damage (By similarity). Could act as a detoxifying agent which removes D-amino acids accumulated during aging (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J203;Q64465;Q8VCW7", "ec_number_list": "2.3.2.27;5.1.99.4;2.6.1.51;2.6.1.44;5.3.3.21;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.1.2.-;3.1.2.2;1.1.1.42;3.6.1.-;3.6.1.77;1.4.3.3;1.11.1.6;1.14.13.39;2.3.1.176;2.3.1.16;2.3.1.155;4.1.3.4;2.3.1.137;2.3.1.7;2.3.2.36;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;2.3.1.42;1.5.3.13;2.3.1.65;1.4.3.1;4.1.1.9;1.1.1.300;1.1.1.184;1.3.1.38;1.5.3.1;1.5.3.7;3.4.21.-;3.4.21.53;2.5.1.18;1.3.3.6;3.4.24.56;1.1.3.15;4.1.2.63;1.2.3.5;5.3.3.8;1.3.1.124", "go_molecular_function": "GO:0042802 identical protein binding;GO:0071949 FAD binding;GO:0003884 D-amino-acid oxidase activity;GO:0008718 D-amino-acid dehydrogenase activity;GO:0043799 glycine oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0070945 neutrophil-mediated killing of gram-negative bacterium;GO:0019478 D-amino acid catabolic process;GO:0036088 D-serine catabolic process;GO:0055130 D-alanine catabolic process;GO:0070178 D-serine metabolic process", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "P18894-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54729-1", "uniprot_id": "NUB1_MOUSE", "mass": 70307.0, "length": 614, "protein_name": "NEDD8 ultimate buster 1", "gene_name": "Nub1", "organism": "Mouse", "refseq_name": "NEDD8 ultimate buster 1 isoform 2", "refseq_ac": "NP_058016", "gene_names_uniprotkb": "Nub1; Nyren18", "gene_names_refseq": "4931404D21Rik; 6330412F12Rik; BS4; NY-REN-18; Nub1", "protein_names_uniprotkb": "NEDD8 ultimate buster 1; Negative regulator of ubiquitin-like proteins 1; Protein BS4", "protein_names_refseq": "NEDD8 ultimate buster 1 isoform 2; NEDD8 ultimate buster 1; NY-REN-18 antigen", "tax_id": 10090, "disease": "", "pathway": " (mmu:53312); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12816948;21750661;22872234;26260793;26797281;28135057;31219806;34428180;37188463;37828378", "class_list": "", "function": "FAT10 and NUB1L cooperate to activate the 26S proteasome. Publication Status: Online-Only, [RefSeq, PubMed]; NUB1 has a splicing variant, NUB1L, which regulates the NEDD8 conjugation system, [RefSeq, PubMed]; NUB1L suppresses atypical neddylation and promotes the degradation of misfolded proteins by the proteasome, [RefSeq, PubMed]; Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation (By similarity)., [UniProtKB]; These results suggest that increased levels of NUB1 play a potential role in degradation of detergent-insoluble alpha-synuclein in vivo, although it is insufficient to degrade abnormal alpha-synuclein in Lewy body disease model mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3U0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0097413 Lewy body", "go_biological_process": "GO:0034612 response to tumor necrosis factor;GO:0016567 protein ubiquitination;GO:0010498 proteasomal protein catabolic process;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P54729-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08760-1", "uniprot_id": "OGG1_MOUSE", "mass": 38883.0, "length": 345, "protein_name": "N-glycosylase/DNA lyase", "gene_name": "Ogg1", "organism": "Mouse", "refseq_name": "N-glycosylase/DNA lyase isoform 1", "refseq_ac": "NP_035087", "gene_names_uniprotkb": "Ogg1", "gene_names_refseq": "Mmh; Ogg1", "protein_names_uniprotkb": "N-glycosylase/DNA lyase", "protein_names_refseq": "N-glycosylase/DNA lyase isoform 1; N-glycosylase/DNA lyase", "tax_id": 10090, "disease": "pterygium (Disease Ontology:DOID:0002116); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); gestational diabetes (Disease Ontology:DOID:11714); Graves' disease (Disease Ontology:DOID:12361); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); hepatitis (Disease Ontology:DOID:2237); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); basal cell carcinoma (Disease Ontology:DOID:2513); transitional cell carcinoma (Disease Ontology:DOID:2671); angiomyolipoma (Disease Ontology:DOID:3314); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); progressive supranuclear palsy (Disease Ontology:DOID:678); cataract (Disease Ontology:DOID:83); type 2 diabetes mellitus (Disease Ontology:DOID:9352); senile cataract (Disease Ontology:DOID:9669)", "pathway": " (mmu:18294); (R-MMU-110329); (R-MMU-110330); (R-MMU-110331); (R-MMU-110357); (R-MMU-5649702)", "pathway_count": 6, "publication_count": 15, "publication_id_list": "21750661;25428506;27816939;30084848;30779550;34428180;37977070;38228016;38822247;39235072;9187114;9197244;9207108;9321410;9434942", "class_list": "", "function": "Catalytic activity of OGG1 is impaired by Zinc deficiency., [RefSeq, PubMed]; DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion., [UniProtKB]; Inhibition of OGG1 ameliorates pulmonary fibrosis via preventing M2 macrophage polarization and activating PINK1-mediated mitophagy. Publication Status: Online-Only, [RefSeq, PubMed]; OGG1 promoted lung fibrosis by activating fibroblasts via interacting with Snail1., [RefSeq, PubMed]; The 8-oxoguanine DNA glycosylase-synaptotagmin 7 pathway increases extracellular vesicle release and promotes tumour metastasis during oxidative stress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 26, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08733;O08910;O08991;O35617;O35915;Q9QXE8", "ec_number_list": "4.2.99.18;3.2.2.-;1.14.11.51;1.14.11.-;1.14.11.33;5.6.2.4;2.7.7.7;4.2.99.-", "go_molecular_function": "GO:0032357 oxidized purine DNA binding;GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity;GO:0003677 DNA binding;GO:0008017 microtubule binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0016607 nuclear speck;GO:0016363 nuclear matrix", "go_biological_process": "GO:1901291 negative regulation of double-strand break repair via single-strand annealing;GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation;GO:0006281 DNA repair;GO:0006979 response to oxidative stress;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O08760-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1E960-1", "uniprot_id": "ODAM_MOUSE", "mass": 29820.0, "length": 273, "protein_name": "Odontogenic ameloblast-associated protein", "gene_name": "Odam", "organism": "Mouse", "refseq_name": "odontogenic ameloblast-associated protein precursor", "refseq_ac": "NP_081404", "gene_names_uniprotkb": "Odam; Apin", "gene_names_refseq": "2310011G06Rik; APIN; Odam", "protein_names_uniprotkb": "Odontogenic ameloblast-associated protein; Apin", "protein_names_refseq": "odontogenic ameloblast-associated protein precursor; odontogenic ameloblast-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:69592)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17647262;20665536;21285247;28436474;33452817", "class_list": "", "function": "Data suggest that amelotin (AMTN), odontogenic ameloblast-associated protein (ODAM) and secretory calcium-binding phosphoprotein proline-glutamine rich 1 (SCPPPQ1) participate in structuring an extracellular matrix with the distinctive capacity of attaching epithelial cells to mineralized surfaces. Publication Status: Online-Only, [RefSeq, PubMed]; ODAM promotes junctional epithelium-related gene expression via activation of WNT1 signaling pathway in an ameloblast-like cell line ALC., [RefSeq, PubMed]; Runx2 regulates the expression of ODAM and nuclear ODAM serves an important regulatory function in the mineralization of enamel through the regulation of MMP-20 apart from a different, currently unidentified, function of extracellular ODAM., [RefSeq, PubMed]; The protein sequences deduced from the cloned cDNA for rat, mouse, pig, and human were aligned together with those obtained from four other mammal genomes. Apin is highly conserved in mammals., [RefSeq, PubMed]; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface., [UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 0, "predicted_o_glycosites": 9, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q9D7E6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0099512 supramolecular fiber;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0006954 inflammatory response;GO:0010628 positive regulation of gene expression;GO:0032956 regulation of actin cytoskeleton organization;GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A1E960-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55241-1", "uniprot_id": "OREX_MOUSE", "mass": 13503.0, "length": 130, "protein_name": "Hypocretin neuropeptide precursor", "gene_name": "Hcrt", "organism": "Mouse", "refseq_name": "hypocretin neuropeptide precursor precursor", "refseq_ac": "NP_034540", "gene_names_uniprotkb": "Hcrt; Ox; Ppox", "gene_names_refseq": "Hcrt; PPOX", "protein_names_uniprotkb": "Hypocretin neuropeptide precursor; Hcrt1; Hcrt2; Hcrt; Hypocretin-1; Hypocretin-2; Hypocretin; Orexin precursor; Prepro-orexin; Preprohypocretin", "protein_names_refseq": "hypocretin neuropeptide precursor precursor; hypocretin neuropeptide; orexin A; orexin B; prepro-orexin; preprohypocretin", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); obstructive sleep apnea (Disease Ontology:DOID:0050848); withdrawal disorder (Disease Ontology:DOID:0060001); sleeping sickness (Disease Ontology:DOID:10112); Prader-Willi syndrome (Disease Ontology:DOID:11983); Guillain-Barre syndrome (Disease Ontology:DOID:12842); alcohol use disorder (Disease Ontology:DOID:1574); cannabis dependence (Disease Ontology:DOID:1849); hyperglycemia (Disease Ontology:DOID:4195); narcolepsy (Disease Ontology:DOID:8986); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:15171); (R-MMU-389397); (R-MMU-416476)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11283317;11340621;21750661;39119889;9419374;9491897", "class_list": "", "function": "Binds to orexin receptor HCRTR2/OX2R only (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity)., [UniProtKB, UniProtKB]; Binds to orexin receptor HCRTR2/OX2R only. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner., [UniProtKB, UniProtKB]; Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity)., [UniProtKB, UniProtKB]; Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner., [UniProtKB, UniProtKB]; Hypocretin-1/Hypocretin Receptor 1 Regulates Neuroplasticity and Cognitive Function through Hippocampal Lactate Homeostasis in Depressed Model., [RefSeq, PubMed]; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested., [UniProtKB, UniProtKB]; This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors Hcrtr1 and Hcrtr2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031771 type 1 orexin receptor binding;GO:0031772 type 2 orexin receptor binding;GO:0160041 neuropeptide activity", "go_cellular_component": "GO:0005791 rough endoplasmic reticulum;GO:0030141 secretory granule;GO:0048471 perinuclear region of cytoplasm;GO:0098794 postsynapse;GO:0099013 neuronal dense core vesicle lumen", "go_biological_process": "GO:0051970 negative regulation of transmission of nerve impulse;GO:0001659 temperature homeostasis;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0042594 response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O55241-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1AZ99-1", "uniprot_id": "OTUD3_MOUSE", "mass": 44576.0, "length": 396, "protein_name": "OTU domain-containing protein 3", "gene_name": "Otud3", "organism": "Mouse", "refseq_name": "OTU domain-containing protein 3 isoform 2", "refseq_ac": "NP_082729", "gene_names_uniprotkb": "Otud3", "gene_names_refseq": "3110030K17Rik; Otud3", "protein_names_uniprotkb": "OTU domain-containing protein 3; 3.4.19.12", "protein_names_refseq": "OTU domain-containing protein 3 isoform 2; OTU domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:73162); (R-MMU-5689896); (R-MMU-8948751)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "31219806;31266968;32679077;34428180;34853315;35490179;35675783;35675826", "class_list": "", "function": "Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity., [RefSeq, PubMed]; Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses., [RefSeq, PubMed]; Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin (PubMed:35675826). Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (PubMed:35675826). Important regulator of energy metabolism (PubMed:35675826). Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation (PubMed:35675826). In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation (PubMed:35675826). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (By similarity)., [UniProtKB, PubMed, UniProtKB]; Deubiquitylase OTUD3 prevents Parkinson's disease through stabilizing iron regulatory protein 2. Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown of OTUD3 results in a decrease in the level of GRP78 protein, suppression of cell growth and migration, and tumorigenesis in lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.19.12;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006508 proteolysis;GO:0016579 protein deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B1AZ99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3YYM0-1", "uniprot_id": "OVOL3_MOUSE", "mass": 21273.0, "length": 189, "protein_name": "Putative transcription factor ovo-like protein 3", "gene_name": "Ovol3", "organism": "Mouse", "refseq_name": "putative transcription factor ovo-like protein 3", "refseq_ac": "NP_001276746", "gene_names_uniprotkb": "Ovol3", "gene_names_refseq": "Gm1903; Ovol3; movo3", "protein_names_uniprotkb": "Putative transcription factor ovo-like protein 3", "protein_names_refseq": "OVO homolog-like 3; putative transcription factor ovo-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:381867)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as a transcription regulator., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0009913 epidermal cell differentiation;GO:2000647 negative regulation of stem cell proliferation;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0009968 negative regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3YYM0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4FZG8-1", "uniprot_id": "OOSP2_MOUSE", "mass": 19223.0, "length": 168, "protein_name": "Oocyte-secreted protein 2", "gene_name": "Oosp2", "organism": "Mouse", "refseq_name": "oocyte-secreted protein 2 precursor", "refseq_ac": "NP_001032723", "gene_names_uniprotkb": "Oosp2; Gm99; Plac1l; Tmem122", "gene_names_refseq": "Gm99; Oosp2; Plac1l; Tmem122", "protein_names_uniprotkb": "Oocyte-secreted protein 2; Placenta-specific 1-like protein", "protein_names_refseq": "oocyte-secreted protein 2 precursor; placenta-specific 1-like protein; transmembrane protein 122", "tax_id": 10090, "disease": "", "pathway": " (mmu:225922)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;36042231", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPM7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0042585 germinal vesicle", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0001556 oocyte maturation;GO:0001824 blastocyst development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4FZG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F7A4A7-1", "uniprot_id": "OTOGL_MOUSE", "mass": 260929.0, "length": 2325, "protein_name": "Otogelin-like protein", "gene_name": "Otogl", "organism": "Mouse", "refseq_name": "otogelin-like protein isoform 1 precursor", "refseq_ac": "NP_001171038", "gene_names_uniprotkb": "Otogl", "gene_names_refseq": "EG628870; Gm6924; Otogl", "protein_names_uniprotkb": "Otogelin-like protein", "protein_names_refseq": "otogelin-like protein isoform 1 precursor; otogelin-like protein", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 84B (Disease Ontology:DOID:0110530)", "pathway": " (mmu:628870)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20472657;23122586;31776257;33300544;34174893;35820727", "class_list": "", "function": "OTOGL, a gelforming mucin protein, is nonessential for male germ cell development and spermatogenesis in mice. Erratum:[Reprod Biol Endocrinol. 2021 Sep 8;19(1):136. doi: 10.1186/s12958-021-00803-3. PMID: 34496867] Publication Status: Online-Only, [RefSeq, PubMed]; Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 7, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "D3JEN5", "ec_number_list": "", "go_molecular_function": "GO:0005201 extracellular matrix structural constituent;GO:0046556 alpha-L-arabinofuranosidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007605 sensory perception of sound;GO:0008104 intracellular protein localization;GO:0060122 inner ear receptor cell stereocilium organization;GO:0046373 L-arabinose metabolic process;GO:0055127 vibrational conductance of sound to the inner ear", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "F7A4A7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21129-1", "uniprot_id": "P3_MOUSE", "mass": 50255.0, "length": 473, "protein_name": "P3 protein", "gene_name": "Slc10a3", "organism": "Mouse", "refseq_name": "P3 protein precursor", "refseq_ac": "NP_001243033", "gene_names_uniprotkb": "Slc10a3; P3", "gene_names_refseq": "DXHXS253E; DXS253Eh; DXSmhG28; P3; Slc10a3", "protein_names_uniprotkb": "P3 protein; Solute carrier family 10 member 3", "protein_names_refseq": "P3 protein precursor; protein P3; solute carrier family 10, member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:214601)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1973144;21750661", "class_list": "", "function": "The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8QZR2", "ec_number_list": "", "go_molecular_function": "GO:0008508 bile acid:sodium symporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0015721 bile acid and bile salt transport;GO:0032526 response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P21129-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54369-1", "uniprot_id": "OAZ1_MOUSE", "mass": 25133.0, "length": 227, "protein_name": "Ornithine decarboxylase antizyme 1", "gene_name": "Oaz1", "organism": "Mouse", "refseq_name": "ornithine decarboxylase antizyme 1 isoform 1", "refseq_ac": "NP_032779", "gene_names_uniprotkb": "Oaz1; Oaz", "gene_names_refseq": "AZ-1; AZ1; Antizyme; ODC-Az; Oaz1; Oaz", "protein_names_uniprotkb": "Ornithine decarboxylase antizyme 1; ODC-Az", "protein_names_refseq": "antizyme 1; ornithine decarboxylase antizyme 1 isoform 1", "tax_id": 10090, "disease": "brain ischemia (Disease Ontology:DOID:2316); coronary restenosis (Disease Ontology:DOID:4247)", "pathway": " (mmu:18245); (R-MMU-350562); (R-MMU-351202)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "16916800;18062773;18508777;19449338;21750661;24967154;26093026;30417362;7813017;9428668", "class_list": "", "function": "Amyloid beta may contribute to M1-like activation by disrupting the balance between ODC and AZ in microglia., [RefSeq, PubMed]; Antizyme expression requires programmed, ribosomal frameshifting, [RefSeq, PubMed]; Interaction of polyamines and mTOR signaling in the synthesis of antizyme (AZ)., [RefSeq, PubMed]; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:16916800, PubMed:18508777). Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (By similarity). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:18062773). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:19449338)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08610", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0044877 protein-containing complex binding;GO:0008073 ornithine decarboxylase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0072750 cellular response to leptomycin B;GO:1902268 negative regulation of polyamine transmembrane transport;GO:0090316 positive regulation of intracellular protein transport;GO:0045732 positive regulation of protein catabolic process;GO:0006596 polyamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P54369-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08600-1", "uniprot_id": "NUCG_MOUSE", "mass": 32191.0, "length": 294, "protein_name": "Endonuclease G, mitochondrial", "gene_name": "Endog", "organism": "Mouse", "refseq_name": "endonuclease G, mitochondrial precursor", "refseq_ac": "NP_031957", "gene_names_uniprotkb": "Endog", "gene_names_refseq": "Endog", "protein_names_uniprotkb": "Endonuclease G, mitochondrial; 3.1.30.-; Endo G", "protein_names_refseq": "endo G; endonuclease G, mitochondrial precursor; endonuclease G, mitochondrial", "tax_id": 10090, "disease": "brain ischemia (Disease Ontology:DOID:2316); congestive heart failure (Disease Ontology:DOID:6000); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (mmu:13804)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14663139;15601850;25355512;32095813;32192768;33473107;34428180;37794041;38977663;9324313", "class_list": "", "function": "Caspase-3 promotes oncogene-induced malignant transformation via EndoG-dependent Src-STAT3 phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]; Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress. Erratum:[Nat Commun. 2024 Aug 21;15(1):7167. doi: 10.1038/s41467-024-51312-x. PMID: 39168977] Publication Status: Online-Only, [RefSeq, PubMed]; EndoG is essential during early embryogenesis and plays a critical role in normal apoptosis and nuclear DNA fragmentation, [RefSeq, PubMed]; Endonuclease G is essential for embryonic survival, but not through a mitochondrial or apoptosis function, [RefSeq, PubMed]; Endonuclease that preferentially catalyzes the cleavage of double-stranded 5-hydroxymethylcytosine (5hmC)-modified DNA (PubMed:25355512, PubMed:32095813). The 5hmC-modified nucleotide does not increase the binding affinity, but instead increases the efficiency of cutting and specifies the site of cleavage for the modified DNAs (PubMed:32095813). Shows significantly higher affinity for four-stranded Holliday junction over duplex and single-stranded DNAs (PubMed:32095813). Promotes conservative recombination when the DNA is 5hmC-modified (PubMed:25355512). Promotes autophagy through the suppression of mTOR by its phosphorylation-mediated interaction with YWHAG and its endonuclease activity-mediated DNA damage response (PubMed:33473107). GSK3-beta mediated phosphorylation of ENDOG enhances its interaction with YWHAG, leading to the release of TSC2 and PIK3C3 from YWHAG resulting in mTOR pathway suppression and autophagy initiation (By similarity). Promotes cleavage of mtDNA in response to oxidative and nitrosative stress, in turn inducing compensatory mtDNA replication (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042803 protein homodimerization activity;GO:0003676 nucleic acid binding;GO:0004520 DNA endonuclease activity;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0043204 perikaryon;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death;GO:0090297 positive regulation of mitochondrial DNA replication;GO:0001701 in utero embryonic development;GO:0034612 response to tumor necrosis factor;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O08600-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09113-1", "uniprot_id": "OTP_MOUSE", "mass": 34159.0, "length": 325, "protein_name": "Homeobox protein orthopedia", "gene_name": "Otp", "organism": "Mouse", "refseq_name": "homeobox protein orthopedia", "refseq_ac": "NP_035151", "gene_names_uniprotkb": "Otp", "gene_names_refseq": "Otp", "protein_names_uniprotkb": "Homeobox protein orthopedia", "protein_names_refseq": "homeobox protein orthopedia; orthopedia homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:18420)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10557207;11071765;17481897;7913821", "class_list": "", "function": "Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0016604 nuclear body", "go_biological_process": "GO:0021879 forebrain neuron differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030182 neuron differentiation;GO:0002052 positive regulation of neuroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O09113-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54734-1", "uniprot_id": "OST48_MOUSE", "mass": 49028.0, "length": 441, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit", "gene_name": "Ddost", "organism": "Mouse", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor", "refseq_ac": "NP_031864", "gene_names_uniprotkb": "Ddost", "gene_names_refseq": "Ddost", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; DDOST 48 kDa subunit; Oligosaccharyl transferase 48 kDa subunit", "protein_names_refseq": "DDOST 48 kDa subunit; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; oligosaccharyl transferase 48 kDa subunit", "tax_id": 10090, "disease": "congenital disorder of glycosylation Ir (Disease Ontology:DOID:0080569)", "pathway": " (mmu:13200); (R-MMU-6798695); (R-MMU-9768727); (R-MMU-9931295)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "19955485;25428506;26320659;26740625;28297665;28947796;30084848;30779550;31219806;31541173;34428180;37155292;37453647;9367678", "class_list": "glycogene", "function": "AGER1 provides protection against AGE-induced reactive oxygen species generation via NADPH oxidase and protein kinase C delta., [RefSeq, PubMed]; Data show that oligosaccharyltransferase (OST) activity is dysregulated in three prime exonuclease 1 knockout (Trex1-/-) cells., [RefSeq, PubMed]; Globally elevating the AGE clearance receptor, OST48, does not protect against the development of diabetic kidney disease, despite improving insulin secretion. Publication Status: Online-Only, [RefSeq, PubMed]; LncRNA TSIX aggravates spinal cord injury by regulating the PI3K/AKT pathway via the miR-532-3p/DDOST axis., [RefSeq, PubMed]; Study demonstrated that dolichyl-diphosphooligosaccharide-protein glycosyltransferase Ost48 (encoded by Ddost gene) is a facilitator of increased advanced glycation end-products (AGE) deposition in the liver and OST48-AGE pathway leads to the onset of liver injury in combination with central adiposity and glucose intolerance, despite ample physical activity. Publication Status: Online-Only, [RefSeq, PubMed]; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The cell-cycle-dependent post-translation modification of TREX1 regulates its interaction with OST., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C4P7", "ec_number_list": "", "go_molecular_function": "GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex;GO:0160226 oligosaccharyltransferase complex A;GO:0160227 oligosaccharyltransferase complex B", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0042110 T cell activation;GO:0031647 regulation of protein stability;GO:0034097 response to cytokine;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O54734-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89013-1", "uniprot_id": "OBRG_MOUSE", "mass": 14316.0, "length": 131, "protein_name": "Leptin receptor gene-related protein", "gene_name": "Leprot", "organism": "Mouse", "refseq_name": "leptin receptor gene-related protein isoform 1", "refseq_ac": "NP_778201", "gene_names_uniprotkb": "Leprot; Lepr; Obr", "gene_names_refseq": "Endo1`; Endospanin1; LEPR; Leprot; OB-RGRP; Obrgrp; VPS55", "protein_names_uniprotkb": "Leptin receptor gene-related protein; Endospanin-1; OB-R gene-related protein; OB-RGRP", "protein_names_refseq": "OB-R gene-related protein; endospanin-1; leptin receptor gene-related protein isoform 1; leptin receptor gene-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:230514)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10849209;18042720;19907080;38716728;9207021", "class_list": "", "function": "Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability., [UniProtKB, PubMed, PubMed]; Whole-body deletion of Endospanin 1 protects from obesity-associated deleterious metabolic alterations. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AV64;Q3TGT4;Q3TWZ2;Q545G9;Q91Z23", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0010008 endosome membrane", "go_biological_process": "GO:0060400 negative regulation of growth hormone receptor signaling pathway;GO:2000009 negative regulation of protein localization to cell surface;GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O89013-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03893-1", "uniprot_id": "NU2M_MOUSE", "mass": 38752.0, "length": 345, "protein_name": "NADH-ubiquinone oxidoreductase chain 2", "gene_name": "mt-Nd2", "organism": "Mouse", "refseq_name": "NADH dehydrogenase subunit 2", "refseq_ac": "NP_904329", "gene_names_uniprotkb": "mt-Nd2; Nd2", "gene_names_refseq": "ND2", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 2; 7.1.1.2; NADH dehydrogenase subunit 2", "protein_names_refseq": "NADH dehydrogenase subunit 2", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); Parkinson's disease (Disease Ontology:DOID:14330); multiple sclerosis (Disease Ontology:DOID:2377); myocardial infarction (Disease Ontology:DOID:5844); mitochondrial metabolism disease (Disease Ontology:DOID:700); Leber hereditary optic neuropathy (Disease Ontology:DOID:705)", "pathway": " (mmu:17717); (R-MMU-5419276); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "12954771;25428506;30084848;31599954;33300544;34428180;38575788;7332926", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:38575788). Essential for the catalytic activity and assembly of complex I (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.-;1.-.-.-;7.1.1.9;7.1.1.2;1.3.8.7;1.3.8.8;3.1.1.29;2.1.1.320;3.6.5.-", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0008137 NADH dehydrogenase (ubiquinone) activity;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0072593 reactive oxygen species metabolic process;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P03893-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03903-1", "uniprot_id": "NU4LM_MOUSE", "mass": 10607.0, "length": 98, "protein_name": "NADH-ubiquinone oxidoreductase chain 4L", "gene_name": "Mtnd4l", "organism": "Mouse", "refseq_name": "NADH dehydrogenase subunit 4L", "refseq_ac": "NP_904336", "gene_names_uniprotkb": "Mtnd4l; Nd4l; mt-Nd4l", "gene_names_refseq": "ND4L", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 4L; 7.1.1.2; NADH dehydrogenase subunit 4L", "protein_names_refseq": "NADH dehydrogenase subunit 4L", "tax_id": 10090, "disease": "Leber hereditary optic neuropathy (Disease Ontology:DOID:705); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:17720); (R-MMU-5419276)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12954771;29915388;34428180;38575788;7332926", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:29915388, PubMed:38575788). Part of the enzyme membrane arm which is embedded in the lipid bilayer and involved in proton translocation (PubMed:29915388)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.1.1.9;7.1.1.2;3.1.1.29;3.6.5.-", "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity;GO:0016651 oxidoreductase activity, acting on NAD(P)H", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042773 ATP synthesis coupled electron transport;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P03903-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03911-1", "uniprot_id": "NU4M_MOUSE", "mass": 51882.0, "length": 459, "protein_name": "NADH-ubiquinone oxidoreductase chain 4", "gene_name": "Mtnd4", "organism": "Mouse", "refseq_name": "NADH dehydrogenase subunit 4", "refseq_ac": "NP_904337", "gene_names_uniprotkb": "Mtnd4; Nd4; mt-Nd4", "gene_names_refseq": "ND4", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 4; 7.1.1.2; NADH dehydrogenase subunit 4", "protein_names_refseq": "NADH dehydrogenase subunit 4", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); macular degeneration (Disease Ontology:DOID:4448); schizophrenia (Disease Ontology:DOID:5419); Leber hereditary optic neuropathy (Disease Ontology:DOID:705)", "pathway": " (mmu:17719); (R-MMU-5419276); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "12954771;25605945;33300544;34428180;37507081;38575788;7332926;8437623", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.-;1.-.-.-;7.1.1.9;7.1.1.2;1.3.8.7;1.3.8.8;3.1.1.29;2.1.1.320;3.6.5.-", "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity;GO:0048039 ubiquinone binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0035094 response to nicotine;GO:0045471 response to ethanol;GO:0001666 response to hypoxia;GO:0032981 mitochondrial respiratory chain complex I assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P03911-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03925-1", "uniprot_id": "NU6M_MOUSE", "mass": 18626.0, "length": 172, "protein_name": "NADH-ubiquinone oxidoreductase chain 6", "gene_name": "Mtnd6", "organism": "Mouse", "refseq_name": "NADH dehydrogenase subunit 6", "refseq_ac": "NP_904339", "gene_names_uniprotkb": "Mtnd6; Nd6; mt-Nd6", "gene_names_refseq": "ND6", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 6; 7.1.1.2; NADH dehydrogenase subunit 6", "protein_names_refseq": "NADH dehydrogenase subunit 6", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); spinal muscular atrophy with lower extremity predominant 2B (Disease Ontology:DOID:0070350); lactic acidosis (Disease Ontology:DOID:3650); Leigh disease (Disease Ontology:DOID:3652); Leber hereditary optic neuropathy (Disease Ontology:DOID:705)", "pathway": " (mmu:17722); (R-MMU-5419276); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "12954771;31219806;34428180;38575788;7332926;9707444", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:9707444, PubMed:38575788). Essential for the catalytic activity and assembly of complex I (PubMed:9707444, PubMed:38575788)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.-;1.-.-.-;7.1.1.9;7.1.1.2;1.3.8.7;1.3.8.8;3.1.1.29;2.1.1.320;3.6.5.-", "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0035094 response to nicotine;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0042542 response to hydrogen peroxide;GO:0042220 response to cocaine;GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P03925-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11928-1", "uniprot_id": "OAS1A_MOUSE", "mass": 42429.0, "length": 367, "protein_name": "2'-5'-oligoadenylate synthase 1A", "gene_name": "Oas1a", "organism": "Mouse", "refseq_name": "2'-5'-oligoadenylate synthase 1A isoform 1", "refseq_ac": "NP_660212", "gene_names_uniprotkb": "Oas1a; Oias1", "gene_names_refseq": "L3; Oas1a", "protein_names_uniprotkb": "2'-5'-oligoadenylate synthase 1A; (2-5')oligo(A) synthase 1A; 2-5A synthase 1A; 2.7.7.84; p42 OAS", "protein_names_refseq": "(2-5')oligo(A) synthase 1A; (2-5')oligo(A) synthetase 1A; 2'-5'-oligoadenylate synthase 1A isoform 1; 2'-5'-oligoadenylate synthase 1A; 2-5A synthase 1A; 2-5A synthetase 1A; p42 OAS", "tax_id": 10090, "disease": "immunodeficiency 100 (Disease Ontology:DOID:0061070)", "pathway": " (mmu:246730)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "12396720;15899864;17024523;1709495;21142819;2171206;22305621;22704621;26739051;27663720;30084848;31219806;34428180;34581622;35820727;3808949", "class_list": "", "function": "Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2, [RefSeq, PubMed]; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:12396720, PubMed:34581622). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed:12396720, PubMed:34581622). Catalyzes the formation of 2'-5'-oligoadenylates (2-5A) from polymerization of ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation (PubMed:12396720, PubMed:34581622). Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:12396720, PubMed:34581622). Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L (PubMed:12396720, PubMed:34581622). Involved in intercellular immune signaling that limits local spread of RNA virus infection and protects against tumorigenesis (By similarity). Can generate high levels of 2',5'-oligoadenylates in transformed cells, targeting them to innate and adaptive immunesurveillance mechanisms (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Mouse hepatitis virus Ns2 cleaves 2',5'-oligoadenylate, the product of 2',5'-oligoadenylate synthetase, to prevent activation of the cellular endoribonuclease RNase L and consequently block viral RNA degradation., [RefSeq, PubMed]; Thus, activation of RNase L does not require mouse hepatitis virus virus-induced interferon but rather correlates with adequate levels of basal Oas gene expression, maintained by basal interferon signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F2Z419;Q3UEC1;Q64440;Q91VI0", "ec_number_list": "2.7.7.84", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0001730 2'-5'-oligoadenylate synthetase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0070106 interleukin-27-mediated signaling pathway;GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production;GO:0035457 cellular response to interferon-alpha;GO:0043129 surfactant homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P11928-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11930-1", "uniprot_id": "NUD19_MOUSE", "mass": 40320.0, "length": 357, "protein_name": "Acyl-coenzyme A diphosphatase NUDT19", "gene_name": "Nudt19", "organism": "Mouse", "refseq_name": "acyl-coenzyme A diphosphatase NUDT19 precursor", "refseq_ac": "NP_149071", "gene_names_uniprotkb": "Nudt19; D7Rp2e", "gene_names_refseq": "D7Rp2-r; D7Rp2-s; D7Rp2e; D7Rp2; Nudt19; RP2-r; RP2-s", "protein_names_uniprotkb": "Acyl-coenzyme A diphosphatase NUDT19; 3.6.1.-; 3.6.1.77; Androgen-regulated protein RP2; Nucleoside diphosphate-linked moiety X motif 19; Nudix motif 19; RP2p; Renal CoA diphosphohydrolase; Testosterone-regulated RP2 protein", "protein_names_refseq": "RP2p; acyl-coenzyme A diphosphatase NUDT19 precursor; acyl-coenzyme A diphosphatase NUDT19; androgen regulated gene RP2; androgen-regulated protein RP2; nucleoside diphosphate-linked moiety X motif 19, mitochondrial; nudix (nucleoside diphosphate linked moiety X)-type motif 19; nudix motif 19; renal CoA diphosphohydrolase; testosterone-regulated RP2 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:110959); (R-MMU-390918); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "16185196;23806337;29378847;32432673;34428180;35367353;3755524", "class_list": "", "function": "Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (PubMed:16185196, PubMed:29378847). Mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters and at low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (PubMed:16185196, PubMed:29378847). Highest activity seen with medium-chain acyl-CoA esters and higher rates of activity seen with the unsaturated acyl-CoA esters compared with the saturated esters (PubMed:16185196). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673)., [UniProtKB, PubMed, PubMed, PubMed]; Nudix hydrolase NUDT19 regulates mitochondrial function and ATP production in murine hepatocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RS21", "ec_number_list": "2.3.2.27;3.6.1.62;3.6.1.64;5.1.99.4;2.6.1.51;2.6.1.44;5.3.3.21;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.1.2.-;3.1.2.2;1.1.1.42;3.6.1.-;3.6.1.77;1.4.3.3;1.11.1.6;1.14.13.39;2.3.1.176;2.3.1.16;2.3.1.155;4.1.3.4;2.3.1.137;2.3.1.7;2.3.2.36;3.6.1.17;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;2.3.1.42;3.6.1.9;3.6.1.68;3.6.1.76;1.5.3.13;2.3.1.65;1.4.3.1;4.1.1.9;1.1.1.300;1.1.1.184;1.3.1.38;1.5.3.1;1.5.3.7;3.4.21.-;3.4.21.53;2.5.1.18;1.3.3.6;3.4.24.56;1.1.3.15;4.1.2.63;1.2.3.5;5.3.3.8;1.3.1.124", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0010945 coenzyme A diphosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome", "go_biological_process": "GO:0036114 medium-chain fatty-acyl-CoA catabolic process;GO:2001294 malonyl-CoA catabolic process;GO:0015938 coenzyme A catabolic process;GO:0044580 butyryl-CoA catabolic process;GO:1901289 succinyl-CoA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P11930-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23275-1", "uniprot_id": "OR2C1_MOUSE", "mass": 34320.0, "length": 312, "protein_name": "Olfactory receptor 2C1", "gene_name": "Or2c1", "organism": "Mouse", "refseq_name": "olfactory receptor 2C1", "refseq_ac": "NP_032788", "gene_names_uniprotkb": "Or2c1; Mor256-17; Olfr15", "gene_names_refseq": "MOR256-17; OR3; Olfr15; Or2c1", "protein_names_uniprotkb": "Olfactory receptor 2C1; Odorant receptor OR3; Olfactory receptor 15; Olfactory receptor 256-17", "protein_names_refseq": "GA_x54KRFPKG5P-348087-349025; odorant receptor OR3; olfactory receptor 15; olfactory receptor 256-17; olfactory receptor 2C1; olfactory receptor MOR256-17", "tax_id": 10090, "disease": "", "pathway": " (mmu:18312); (R-MMU-381753)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1384038;15342743;25901328;29367680;29659735;29885841", "class_list": "", "function": "In islets from type 2 diabetic mice, the expression level of Olfr15 and the octanoic acid-induced enhancement of glucose-stimulated insulin secretion were strongly reduced., [RefSeq, PubMed]; Olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups such as (methylthio)methanetiol (MTMT) (PubMed:29659735). Also binds odorants acetophenone and benzaldehyde (PubMed:25901328). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (Probable). May be involved in the molecular processes underlying fasciculation and targeting of olfactory axons (PubMed:15342743)., [UniProtKB, PubMed, PubMed, PubMed]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; These findings suggest that Olfr15 and Olfr821 in pancreatic beta-cells has a chemo-sensor function allowing recognition of environmental substances obtained from food, and potentiates insulin secretion in a cell-autonomous manner, thereby modulating systemic glucose metabolism. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q496W6;Q8VFF0", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0050907 detection of chemical stimulus involved in sensory perception;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P23275-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33534-1", "uniprot_id": "OPRK_MOUSE", "mass": 42652.0, "length": 380, "protein_name": "Kappa-type opioid receptor", "gene_name": "Oprk1", "organism": "Mouse", "refseq_name": "kappa-type opioid receptor isoform 1", "refseq_ac": "NP_001191300", "gene_names_uniprotkb": "Oprk1", "gene_names_refseq": "K-OR-1; KOR-1; KOR; MSL-1; Oprk1; Oprk2; R21", "protein_names_uniprotkb": "Kappa-type opioid receptor; K-OR-1; KOR-1; MSL-1", "protein_names_refseq": "kappa-type opioid receptor isoform 1; kappa-type opioid receptor; opioid receptor, kappa 2", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); opioid abuse (Disease Ontology:DOID:11206); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); opiate dependence (Disease Ontology:DOID:2559); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); neonatal abstinence syndrome (Disease Ontology:DOID:9828); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:18387); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "14597630;16648139;21750661;26635353;35652052;7499487;7733933;7802669;8393575;9463367", "class_list": "", "function": "G protein-coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions., [UniProtKB, PubMed, PubMed]; G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions., [UniProtKB, UniProtKB]; This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0038048 dynorphin receptor activity;GO:0033612 receptor serine/threonine kinase binding;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:1904000 positive regulation of eating behavior;GO:0006955 immune response;GO:0007218 neuropeptide signaling pathway;GO:0007626 locomotory behavior;GO:0035094 response to nicotine", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P33534-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53347-1", "uniprot_id": "ONCM_MOUSE", "mass": 30114.0, "length": 263, "protein_name": "Oncostatin-M", "gene_name": "Osm", "organism": "Mouse", "refseq_name": "oncostatin-M precursor", "refseq_ac": "NP_001013383", "gene_names_uniprotkb": "Osm", "gene_names_refseq": "OncoM; Osm", "protein_names_uniprotkb": "Oncostatin-M; OSM", "protein_names_refseq": "oncostatin-M precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:18413); (R-MMU-6788467)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "38569555;39532904;8605875;9584176;9920829", "class_list": "", "function": "Functions as a cytokine that uses only the type II OSM receptor (heterodimers composed of OSMR and IL6ST) (PubMed:9920829). Functionally, regulates many processes including cell proliferation, cell differentiation, cytokine production (PubMed:39532904, PubMed:8605875, PubMed:9920829). Mechanistically, low affinity ligand binding to IL6ST/gp130, induces heterodimerization with OSMR, activating JAK tyrosine kinases (JAK1 or JAK2 and to a lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR or OSMR. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of STAT3 and STAT5B. Moreover, the type II OSM complex receptor recruits SHC1 through OSMR in a JAK1 mediated phosphotyrosine-dependent manner, leading to SHC1 association with GRB2 and downstream activation of the Ras/Raf/MAPK pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Oncostatin M signaling drives cancer-associated skeletal muscle wasting., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U1Y5;Q5SPX6", "ec_number_list": "", "go_molecular_function": "GO:0005147 oncostatin-M receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0038165 oncostatin-M-mediated signaling pathway;GO:0032740 positive regulation of interleukin-17 production;GO:0006955 immune response;GO:0008284 positive regulation of cell population proliferation;GO:0033138 positive regulation of peptidyl-serine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P53347-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54615-1", "uniprot_id": "OSTR_MOUSE", "mass": 10459.0, "length": 95, "protein_name": "Osteocalcin-related protein", "gene_name": "Bglap3", "organism": "Mouse", "refseq_name": "osteocalcin-related protein precursor", "refseq_ac": "NP_001292377", "gene_names_uniprotkb": "Bglap3; Bglap-rs1", "gene_names_refseq": "Bglap-rs1; Bglap3; OC-X; ORG; mOC-X", "protein_names_uniprotkb": "Osteocalcin-related protein; Gamma-carboxyglutamic acid-containing protein 3; Nephrocalcin; OC-X", "protein_names_refseq": "bone gamma-carboxyglutamate protein, related sequence 1; gamma-carboxyglutamic acid-containing protein 3; nephrocalcin; osteocalcin-related protein precursor; osteocalcin-related protein", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); polycystic kidney disease (Disease Ontology:DOID:0080322); calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652); autosomal dominant hypocalcemia (Disease Ontology:DOID:0090109); neurofibromatosis 1 (Disease Ontology:DOID:0111253); progressive osseous heteroplasia (Disease Ontology:DOID:0111535); prostate cancer (Disease Ontology:DOID:10283); vitamin K deficiency bleeding (Disease Ontology:DOID:11249); osteoporosis (Disease Ontology:DOID:11476); nephrotic syndrome (Disease Ontology:DOID:1184); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); calcinosis (Disease Ontology:DOID:182); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetes insipidus (Disease Ontology:DOID:9409); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12095)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8243336;8288580", "class_list": "", "function": "Binds strongly to apatite and calcium., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q78H72", "ec_number_list": "", "go_molecular_function": "GO:0008147 structural constituent of bone;GO:0005509 calcium ion binding;GO:0046848 hydroxyapatite binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0016311 dephosphorylation;GO:1900076 regulation of cellular response to insulin stimulus;GO:0060348 bone development;GO:0031214 biomineral tissue development;GO:0001649 osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P54615-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58307-1", "uniprot_id": "OX1R_MOUSE", "mass": 46781.0, "length": 416, "protein_name": "Orexin/Hypocretin receptor type 1", "gene_name": "Hcrtr1", "organism": "Mouse", "refseq_name": "orexin/Hypocretin receptor type 1 isoform 1", "refseq_ac": "NP_001156499", "gene_names_uniprotkb": "Hcrtr1", "gene_names_refseq": "Hcrtr1; Ox1r; ox-1-R; ox1-R", "protein_names_uniprotkb": "Orexin/Hypocretin receptor type 1; Hypocretin receptor type 1; Orexin receptor type 1; Ox-1-R; Ox1-R; Ox1R", "protein_names_refseq": "hypocretin receptor type 1; orexin receptor type 1; orexin/Hypocretin receptor type 1 isoform 1; orexin/Hypocretin receptor type 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:230777); (R-MMU-389397); (R-MMU-416476)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12679517;15256537;36689149;39119889", "class_list": "", "function": "Alpha-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation., [RefSeq, PubMed]; G protein-coupled receptor that binds the neuropeptide orexin-A with high affinity, and orexin-B with lower affinity, two peptides derived from a common precursor, prepro-orexin. Its activity is mediated via a G(q)-protein-coupled pathway, which activates the phosphatidylinositol-calcium second messenger system in response to orexin-A binding. In addition to G(q)-mediated signaling, orexin-A stimulation also promotes beta-arrestin recruitment, leading to receptor internalization (By similarity). Plays a significant role in the regulation of food intake (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Hypocretin-1/Hypocretin Receptor 1 Regulates Neuroplasticity and Cognitive Function through Hippocampal Lactate Homeostasis in Depressed Model., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0VDP5;Q3USS9;Q6VNS3;Q80T45", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0017046 peptide hormone binding;GO:0016499 orexin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0032870 cellular response to hormone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P58307-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59235-1", "uniprot_id": "NUP43_MOUSE", "mass": 41990.0, "length": 380, "protein_name": "Nucleoporin Nup43", "gene_name": "Nup43", "organism": "Mouse", "refseq_name": "nucleoporin Nup43", "refseq_ac": "NP_663752", "gene_names_uniprotkb": "Nup43", "gene_names_refseq": "2610016K01Rik; 2610529I12Rik; Nup43; p42", "protein_names_uniprotkb": "Nucleoporin Nup43; Nup107-160 subcomplex subunit Nup43", "protein_names_refseq": "nucleoporin 43kDa; nucleoporin Nup43; nup107-160 subcomplex subunit Nup43", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:69912); (R-MMU-141430); (R-MMU-141444); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9615933); (R-MMU-9648025)", "pathway_count": 26, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QPN3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0007059 chromosome segregation;GO:0015031 protein transport;GO:0051301 cell division;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P59235-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P83503-1", "uniprot_id": "NYX_MOUSE", "mass": 52431.0, "length": 476, "protein_name": "Nyctalopin", "gene_name": "Nyx", "organism": "Mouse", "refseq_name": "nyctalopin precursor", "refseq_ac": "NP_775591", "gene_names_uniprotkb": "Nyx", "gene_names_refseq": "CLNP; CSNB1; CSNB4; Nyx; nob", "protein_names_uniprotkb": "Nyctalopin", "protein_names_refseq": "no b wave; nyctalopin precursor", "tax_id": 10090, "disease": "congenital stationary night blindness (Disease Ontology:DOID:0050534); congenital stationary night blindness 1A (Disease Ontology:DOID:0110870); night blindness (Disease Ontology:DOID:8499)", "pathway": " (mmu:236690)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12506099;12714669;14507859;17881478;21734298;21832182", "class_list": "glycogene", "function": "Human and mouse nyctalopin are membrane-bound extracellular proteins and are functionally conserved., [RefSeq, PubMed]; Required for normal vision. Is a critical factor for light-induced depolarization of retinal ON-bipolar cells, likely acting as a scaffold for TRPM1 and GRM6 (PubMed:21832182). Required for TRPM1 trafficking to dendritic tips of ON-bipolar cells (PubMed:21734298)., [UniProtKB, PubMed, PubMed, PubMed]; The nob phenotype is caused by an 85-bp deletion in the mouse nyx gene, which encodes the nyctalopin protein., [RefSeq, PubMed]; These data suggest an important function of the Nyx protein in the inner retina and provide evidence that CSNB1 is based on a defect in the inner retinal circuitry., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8BYN4", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0030425 dendrite;GO:0031012 extracellular matrix;GO:0098794 postsynapse;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P83503-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TZ65-1", "uniprot_id": "CMA1D_MOUSE", "mass": 29757.0, "length": 277, "protein_name": "Protein CIMAP1D", "gene_name": "Cimap1d", "organism": "Mouse", "refseq_name": "protein CIMAP1D", "refseq_ac": "NP_001028645", "gene_names_uniprotkb": "Cimap1d; Gm1157; Odf3l2", "gene_names_refseq": "Cimap1d; Gm1157; Odf3l2", "protein_names_uniprotkb": "Protein CIMAP1D; Outer dense fiber protein 3-like protein 2", "protein_names_refseq": "outer dense fiber of sperm tails 3-like 2; outer dense fiber protein 3-like protein 2; protein CIMAP1D", "tax_id": 10090, "disease": "", "pathway": " (mmu:382384)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RVV0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005881 cytoplasmic microtubule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3TZ65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U0K8-1", "uniprot_id": "OGFD1_MOUSE", "mass": 62734.0, "length": 545, "protein_name": "Prolyl 3-hydroxylase OGFOD1", "gene_name": "Ogfod1", "organism": "Mouse", "refseq_name": "prolyl 3-hydroxylase OGFOD1 isoform 2", "refseq_ac": "NP_001087226", "gene_names_uniprotkb": "Ogfod1; Kiaa1612", "gene_names_refseq": "4930415J21Rik; Ogfod1; mKIAA1612", "protein_names_uniprotkb": "Prolyl 3-hydroxylase OGFOD1; 1.14.11.-; 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1; uS12 prolyl 3-hydroxylase", "protein_names_refseq": "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1; prolyl 3-hydroxylase OGFOD1 isoform 2; prolyl 3-hydroxylase OGFOD1; uS12 prolyl 3-hydroxylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:270086); (R-MMU-9629569)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;34428180;34668514;37084634;38843265", "class_list": "", "function": "Deleting the ribosomal prolyl hydroxylase OGFOD1 protects mice against diet-induced obesity and insulin resistance. Publication Status: Online-Only, [RefSeq, PubMed]; OGFOD1 modulates the transcriptional and proteomic landscapes to alter isoproterenol-induced hypertrophy susceptibility., [RefSeq, PubMed]; Ogfod1 deletion increases cardiac beta-alanine levels and protects mice against ischaemia- reperfusion injury., [RefSeq, PubMed]; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLS5;Q3TPR4;Q80TB3;Q8CFR6", "ec_number_list": "1.14.11.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0031543 peptidyl-proline dioxygenase activity;GO:0031544 peptidyl-proline 3-dioxygenase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule;GO:0005634 nucleus", "go_biological_process": "GO:0006449 regulation of translational termination;GO:0008283 cell population proliferation;GO:0034063 stress granule assembly;GO:0019511 peptidyl-proline hydroxylation;GO:0018126 protein hydroxylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3U0K8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXV1-1", "uniprot_id": "CBX8_MOUSE", "mass": 39860.0, "length": 362, "protein_name": "Chromobox protein homolog 8", "gene_name": "Cbx8", "organism": "Mouse", "refseq_name": "chromobox protein homolog 8", "refseq_ac": "NP_038954", "gene_names_uniprotkb": "Cbx8; Pc3", "gene_names_refseq": "Cbx8; Pc3", "protein_names_uniprotkb": "Chromobox protein homolog 8; Pc3; Polycomb 3 homolog; mPc3", "protein_names_refseq": "chromobox homolog 8; chromobox protein homolog 8; mPc3; polycomb 3 homolog", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); glioblastoma (Disease Ontology:DOID:3068); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (mmu:30951); (R-MMU-3108214); (R-MMU-3899300); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-8939243); (R-MMU-8943724)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "10721694;11439343;16359901;16537902;17242355;21183079;27555324;34428180", "class_list": "", "function": "CBX8 plates roles in epigenetic regulation in DNA damage response. Erratum:[J Biol Chem. 2017 Jan 13;292(2):761. doi: 10.1074/jbc.A116.725879. PMID: 28087730], [RefSeq, PubMed]; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003727 single-stranded RNA binding;GO:0061628 histone H3K27me3 reader activity;GO:0097027 ubiquitin-protein transferase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0000792 heterochromatin;GO:0031519 PcG protein complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0032967 positive regulation of collagen biosynthetic process;GO:0045739 positive regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QXV1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUI0-1", "uniprot_id": "MIXL1_MOUSE", "mass": 24844.0, "length": 231, "protein_name": "Homeobox protein MIXL1", "gene_name": "Mixl1", "organism": "Mouse", "refseq_name": "homeobox protein MIXL1", "refseq_ac": "NP_038757", "gene_names_uniprotkb": "Mixl1; Mix; Mml", "gene_names_refseq": "Mixl1; Mm1; Mml", "protein_names_uniprotkb": "Homeobox protein MIXL1; Homeodomain protein MIX; MIX1 homeobox-like protein 1; Mix.1 homeobox-like protein; mMix", "protein_names_refseq": "MIX1 homeobox-like protein 1; Mix1 homeobox-like 1; homeobox protein MIXL1; homeodomain protein MIX; mMix; mix.1 homeobox-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:27217)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10495285;11084649;12095687;12117810;12619131;15673572;15982639;16403910;16433620;17060613;17151016;17446562;17568773", "class_list": "", "function": "Required for the morphogenesis of axial mesoderm, the heart and the gut during embryogenesis, [RefSeq, PubMed]; Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZ61", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9WUI0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80U04-1", "uniprot_id": "PJA2_MOUSE", "mass": 77958.0, "length": 707, "protein_name": "E3 ubiquitin-protein ligase Praja-2", "gene_name": "Pja2", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase Praja-2 isoform a", "refseq_ac": "NP_001020480", "gene_names_uniprotkb": "Pja2; Kiaa0438; Rnf131", "gene_names_refseq": "Neurodap1; Pja2; mKIAA0438", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Praja-2; 2.3.2.27; Praja2; RING finger protein 131; RING-type E3 ubiquitin transferase Praja-2", "protein_names_refseq": "E3 ubiquitin-protein ligase Praja-2 isoform a; E3 ubiquitin-protein ligase Praja-2; E3 ubiquitin-protein ligase Praja2; RING finger protein 131; RING-type E3 ubiquitin transferase Praja-2; neurodegeneration associated protein 1; praja 2, RING-H2 motif containing; praja-2; praja2; protein carrying the RING-H2 sequence motif", "tax_id": 10090, "disease": "", "pathway": " (mmu:224938); (R-MMU-983168)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12036302;18299400;22872234;25428506;27195677;28135057;30084848;30779550;32267716;34428180;35820727;38379085", "class_list": "", "function": "Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype. Plays a role in ciliogenesis by ubiquitinating OFD1., [UniProtKB, UniProtKB]; Pja2 regulated hippocampal neuronal cell development and the expression of Alzheimer disease marker genes by inhibiting P2rx3/promoting P2rx7 expression., [RefSeq, PubMed]; Praja2 regulates KSR1 stability and mitogenic signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TH95;Q810E3;Q91W46;Q99KC0", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.11.1;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0008270 zinc ion binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0034237 protein kinase A regulatory subunit binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0046330 positive regulation of JNK cascade;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q80U04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62093-1", "uniprot_id": "SRSF2_MOUSE", "mass": 25476.0, "length": 221, "protein_name": "Serine/arginine-rich splicing factor 2", "gene_name": "Srsf2", "organism": "Mouse", "refseq_name": "serine/arginine-rich splicing factor 2", "refseq_ac": "NP_035488", "gene_names_uniprotkb": "Srsf2; Pr264; Sfrs10; Sfrs2", "gene_names_refseq": "D11Wsu175e; MRF-1; Pr264; SC35; Sfrs10; Sfrs2; Srsf2", "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 2; MRF-1; Protein PR264; Putative myelin regulatory factor 1; SC-35; Splicing component, 35 kDa; Splicing factor SC35; Splicing factor, arginine/serine-rich 2", "protein_names_refseq": "myelin regulatory factor 1; putative myelin regulatory factor 1; serine/arginine-rich splicing factor 2; splicing component, 35 kDa; splicing factor Sc35; splicing factor, arginine/serine-rich 2 (SC-35)", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); pulmonary neuroendocrine tumor (Disease Ontology:DOID:5410); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:20382); (R-MMU-159236); (R-MMU-72163); (R-MMU-72165); (R-MMU-72187); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22570411;37828378;38713535;38806724;39265887;7527040;9774382", "class_list": "", "function": "A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies. Publication Status: Online-Only, [RefSeq, PubMed]; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment (By similarity). Can bind to the myelin basic protein (MBP) gene MB3 regulatory region and increase transcription of the mbp promoter in cells derived from the CNS (PubMed:7527040)., [UniProtKB, UniProtKB, PubMed]; PARP inhibition leads to synthetic lethality with key splicing-factor mutations in myelodysplastic syndromes., [RefSeq, PubMed]; SRSF2 is essential for maintaining pancreatic beta-cell identity and regulating glucose homeostasis in mice., [RefSeq, PubMed]; The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q542L3;Q60701", "ec_number_list": "", "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003729 mRNA binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005726 perichromatin fibrils;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0033197 response to vitamin E;GO:0008380 RNA splicing;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q62093-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61827-1", "uniprot_id": "MAFK_MOUSE", "mass": 17537.0, "length": 156, "protein_name": "Transcription factor MafK", "gene_name": "Mafk", "organism": "Mouse", "refseq_name": "transcription factor MafK", "refseq_ac": "NP_034887", "gene_names_uniprotkb": "Mafk; Nfe2u", "gene_names_refseq": "Mafk; NF-E2; Nfe2u", "protein_names_uniprotkb": "Transcription factor MafK; Erythroid transcription factor NF-E2 p18 subunit", "protein_names_refseq": "erythroid transcription factor NF-E2 p18 subunit; nuclear factor, erythroid derived 2, ubiquitous; p18 NF-E2; transcription factor MafK; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K", "tax_id": 10090, "disease": "", "pathway": " (mmu:17135); (R-MMU-9707616); (R-MMU-9708530); (R-MMU-983231)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "21183079;21606357;25896808;26901059;30059200;32782141;32848054;35822049;36852467;40021952;40885482;40997131;7706310;8265578;9240432", "class_list": "", "function": "Beta-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development Publication Status: Online-Only, [RefSeq, PubMed]; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (By similarity). However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:9240432). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (By similarity)., [UniProtKB, UniProtKB, PubMed]; These data identify Mafg and Mafk as new cataract-associated candidates and define their function in regulating largely non-crystallin genes linked to human cataract., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q60600", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q61827-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54227-1", "uniprot_id": "STMN1_MOUSE", "mass": 17274.0, "length": 149, "protein_name": "Stathmin", "gene_name": "Stmn1", "organism": "Mouse", "refseq_name": "stathmin isoform 1", "refseq_ac": "NP_062615", "gene_names_uniprotkb": "Stmn1; Lag; Lap18; Pr22", "gene_names_refseq": "19k; Lag; Lap18; Op18; P18; P19; Pig; Pp17; Pp18; Pp19; Pr22; Smn; Stmn1", "protein_names_uniprotkb": "Stathmin; Leukemia-associated gene protein; Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; Prosolin; Protein Pr22; pp17; pp19", "protein_names_refseq": "leukemia-associated gene protein; leukemia-associated phosphoprotein p18; metablastin; oncoprotein 18; oncoprotein18; phosphoprotein p19; prosolin; stathmin isoform 1", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:16765)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "10.1101/2023.09.13.557529;10913145;15345747;16286011;17114649;17242355;19033656;19131326;19688729;20173027;21183079;21750661;23806337;25007915;25605945;26192747;26740625;30082792;31909354;32251425;33260083;34428180;34827581;35820727;39927985;7724523;8288240;8376365;8906359", "class_list": "", "function": "BetaPix-d regulates the phosphorylation of Stathmin1 in a PAK-dependent manner. Erratum:[PLoS One. 2020 May 13;15(5):e0233327. doi: 10.1371/journal.pone.0233327. PMID: 32401784] Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis (By similarity). Involved in the control of the learned and innate fear., [UniProtKB, PubMed]; Stathmin 1 deficiency induces erythro-megakaryocytic defects leading to macrocytic anemia and thrombocythemia in Stathmin 1 knock out mice., [RefSeq, PubMed]; The Essential Role of Stathmin in Myoblast C2C12 for Vertical Vibration-Induced Myotube Formation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0016020 membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0007409 axonogenesis;GO:0031175 neuron projection development;GO:0061436 establishment of skin barrier;GO:0009615 response to virus", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P54227-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0X0-2", "uniprot_id": "LCA5L_MOUSE", "mass": 81992.0, "length": 735, "protein_name": "Lebercilin-like protein", "gene_name": "Lca5l", "organism": "Mouse", "refseq_name": "lebercilin-like protein isoform 1", "refseq_ac": "NP_001001492", "gene_names_uniprotkb": "Lca5l", "gene_names_refseq": "4921526F01Rik; Lca5l; Lcca5l", "protein_names_uniprotkb": "Lebercilin-like protein; Leber congenital amaurosis 5-like protein", "protein_names_refseq": "leber congenital amaurosis 5-like protein; lebercilin-like protein isoform 1; lebercilin-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:385668)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A5H1ZRK7;B9EJ20;D3YXG9;E9QN53", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005930 axoneme", "go_biological_process": "GO:0042073 intraciliary transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8C0X0-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQ09-1", "uniprot_id": "OLR1_MOUSE", "mass": 41643.0, "length": 363, "protein_name": "Oxidized low-density lipoprotein receptor 1", "gene_name": "Olr1", "organism": "Mouse", "refseq_name": "oxidized low-density lipoprotein receptor 1 isoform 1", "refseq_ac": "NP_619589", "gene_names_uniprotkb": "Olr1; Lox1", "gene_names_refseq": "LOX-1; Olr1; SR-EI; Scare1", "protein_names_uniprotkb": "Oxidized low-density lipoprotein receptor 1; LOX-1; Lectin-like oxLDL receptor 1; Lectin-like oxidized LDL receptor 1; Lectin-type oxidized LDL receptor 1; Ox-LDL receptor 1", "protein_names_refseq": "lectin-like oxLDL receptor 1; lectin-like oxidized LDL receptor 1; lectin-type oxidized LDL receptor 1; ox-LDL receptor 1; oxidised low density lipoprotein (lectin-like) receptor 1; oxidized low-density lipoprotein receptor 1 isoform 1; oxidized low-density lipoprotein receptor 1", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); coronary artery disease (Disease Ontology:DOID:3393); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); cerebral amyloid angiopathy (Disease Ontology:DOID:9246)", "pathway": " (mmu:108078); (R-MMU-202733); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "15561273;15935375;21750661;36264633;37468019;37984156;38141905;38253620;9588202", "class_list": "glycogene", "function": "Alloimmunw responses induce up-regulation of LOX-1 mRNA in transplanted hearts., [RefSeq, PubMed]; Knockdown of LOX-1 ameliorates bone quality and generation of type H blood vessels in diabetic mice., [RefSeq, PubMed]; LOX-1 acts as an N[6]-methyladenosine-regulated receptor for Helicobacter pylori by binding to the bacterial catalase. Publication Status: Online-Only, [RefSeq, PubMed]; Lectin-like oxidized low-density lipoprotein receptor 1 attenuates pneumonia-induced lung injury. Publication Status: Online-Only, [RefSeq, PubMed]; Macrophage KLF15 prevents foam cell formation and atherosclerosis via transcriptional suppression of OLR-1., [RefSeq, PubMed]; Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15., [RefSeq, PubMed]; Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity)., [UniProtKB]; The essential role of cytoplasmic sequences of LOX-1 for cell-surface sorting is established., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 33, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3M1", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0030246 carbohydrate binding;GO:0005041 low-density lipoprotein particle receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0045121 membrane raft", "go_biological_process": "GO:0006954 inflammatory response;GO:0042157 lipoprotein metabolic process;GO:0007159 leukocyte cell-cell adhesion;GO:0002376 immune system process;GO:1902894 negative regulation of miRNA transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9EQ09-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZWY3-1", "uniprot_id": "RS27L_MOUSE", "mass": 9477.0, "length": 84, "protein_name": "Small ribosomal subunit protein eS27-like", "gene_name": "Rps27l", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein eS27-like isoform 2", "refseq_ac": "NP_080743", "gene_names_uniprotkb": "Rps27l", "gene_names_refseq": "1810034D23Rik; Rps27l", "protein_names_uniprotkb": "Small ribosomal subunit protein eS27-like; 40S ribosomal protein S27-like", "protein_names_refseq": "40S ribosomal protein S27-like protein; small ribosomal subunit protein eS27-like isoform 2; small ribosomal subunit protein eS27-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:67941); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 9, "publication_id_list": "20173027;21750661;25144937;29396424;30084848;30779550;34428180;37453647;39627609", "class_list": "", "function": "Data suggest that ribosomal protein S27-like (Rps27l) is an essential gene for postnatal development by modulating tumor suppressor protein p53. Publication Status: Online-Only, [RefSeq, PubMed]; This study revealed a physiological condition under which Rps27l regulates the Mdm2/p53 and MRN/Atm axes to maintain DNA damage response and to confer radioprotection in vivo. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UB68", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0008494 translation activator activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0006412 translation;GO:0045727 positive regulation of translation;GO:0030330 DNA damage response, signal transduction by p53 class mediator;GO:0031571 mitotic G1 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6ZWY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BWU5-1", "uniprot_id": "OSGEP_MOUSE", "mass": 36301.0, "length": 335, "protein_name": "tRNA N6-adenosine threonylcarbamoyltransferase", "gene_name": "Osgep", "organism": "Mouse", "refseq_name": "tRNA N6-adenosine threonylcarbamoyltransferase", "refseq_ac": "NP_598437", "gene_names_uniprotkb": "Osgep", "gene_names_refseq": "1500019L24Rik; GCPL-1; Osgep; PRSMG1", "protein_names_uniprotkb": "tRNA N6-adenosine threonylcarbamoyltransferase; 2.3.1.234; N6-L-threonylcarbamoyladenine synthase; O-sialoglycoprotein endopeptidase; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgep; tRNA threonylcarbamoyladenosine biosynthesis protein Osgep", "protein_names_refseq": "N6-L-threonylcarbamoyladenine synthase; mOsgep; probable O-sialoglycoprotein endopeptidase; probable tRNA N6-adenosine threonylcarbamoyltransferase; probable tRNA threonylcarbamoyladenosine biosynthesis protein Osgep; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgep; tRNA N6-adenosine threonylcarbamoyltransferase", "tax_id": 10090, "disease": "primary hypomagnesemia (Disease Ontology:DOID:0060879); Galloway-Mowat syndrome 3 (Disease Ontology:DOID:0080245); proteinuria (Disease Ontology:DOID:576)", "pathway": " (mmu:66246)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12200116;21750661;28805828", "class_list": "", "function": "Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity., [UniProtKB, HAMAP]; Promoter regions and tissue distribution of Osgep, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99LN8", "ec_number_list": "2.3.1.234", "go_molecular_function": "GO:0046872 metal ion binding;GO:0061711 tRNA N(6)-L-threonylcarbamoyladenine synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000408 EKC/KEOPS complex", "go_biological_process": "GO:0006400 tRNA modification;GO:0002949 tRNA threonylcarbamoyladenosine modification;GO:0070525 tRNA threonylcarbamoyladenosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BWU5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XL9-1", "uniprot_id": "OSBL1_MOUSE", "mass": 107795.0, "length": 950, "protein_name": "Oxysterol-binding protein-related protein 1", "gene_name": "Osbpl1a", "organism": "Mouse", "refseq_name": "oxysterol-binding protein-related protein 1 isoform 2", "refseq_ac": "NP_001239418", "gene_names_uniprotkb": "Osbpl1a; Orp1a; Orp1l; Orp1", "gene_names_refseq": "G430090F17Rik; Gm753; ORP-1; Osbpl1a; Osbpl1b", "protein_names_uniprotkb": "Oxysterol-binding protein-related protein 1; ORP-1; OSBP-related protein 1", "protein_names_refseq": "OSBP-related protein 1; oxysterol-binding protein-related protein 1 isoform 2; oxysterol-binding protein-related protein 1", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545)", "pathway": " (mmu:64291); (R-MMU-192105); (R-MMU-2132295)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12215260;15871461;17303778;20690035;21750661;22623793;37507081", "class_list": "", "function": "Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol., [UniProtKB, UniProtKB]; OSBP regulates hepatic TG metabolism and suggest the involvement of OSBP in the insulin signaling pathways that control hepatic lipogenesis., [RefSeq, PubMed]; Osbpl1a silencing in macrophage foam cells enhances endosome motility and results in inhibition of [(3)H]cholesterol efflux to apolipoprotein A-I., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88318;Q3TH97;Q673L8;Q6DFU6", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0032935 sterol sensor activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0044232 organelle membrane contact site;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0097038 perinuclear endoplasmic reticulum", "go_biological_process": "GO:0042632 cholesterol homeostasis;GO:0090120 lysosome to ER cholesterol transport;GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91XL9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62305-1", "uniprot_id": "RUXE_MOUSE", "mass": 10804.0, "length": 92, "protein_name": "Small nuclear ribonucleoprotein E", "gene_name": "Snrpe", "organism": "Mouse", "refseq_name": "small nuclear ribonucleoprotein E", "refseq_ac": "NP_033253", "gene_names_uniprotkb": "Snrpe", "gene_names_refseq": "SME; Snrpe; sm-E; snRNP-E", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein E; Sm protein E; Sm-E; SmE; snRNP-E", "protein_names_refseq": "sm protein E; small nuclear ribonucleoprotein E", "tax_id": 10090, "disease": "lupus nephritis (Disease Ontology:DOID:0080162); hypotrichosis 1 (Disease Ontology:DOID:0110698); hypotrichosis 11 (Disease Ontology:DOID:0110708); prostate cancer (Disease Ontology:DOID:10283); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); neuroblastoma (Disease Ontology:DOID:769); nasopharynx carcinoma (Disease Ontology:DOID:9261); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:20643); (R-MMU-111367); (R-MMU-191859); (R-MMU-72163); (R-MMU-72165); (R-MMU-73856); (R-MMU-77588); (R-MMU-9770562)", "pathway_count": 8, "publication_count": 9, "publication_id_list": "1478669;21750661;25428506;30084848;31219806;33649389;34428180;35820727;37828378", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P08578;Q15498", "ec_number_list": "", "go_molecular_function": "GO:1990446 U1 snRNP binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0034709 methylosome", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P62305-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14B46-1", "uniprot_id": "RTKN2_MOUSE", "mass": 66962.0, "length": 604, "protein_name": "Rhotekin-2", "gene_name": "Rtkn2", "organism": "Mouse", "refseq_name": "rhotekin-2 isoform 1", "refseq_ac": "NP_001346247", "gene_names_uniprotkb": "Rtkn2; Plekhk1", "gene_names_refseq": "B130039D23Rik; Mbf; Plekhk1; Rtkn2", "protein_names_uniprotkb": "Rhotekin-2; PH domain-containing family K member 1; Pleckstrin homology domain-containing family K member 1", "protein_names_refseq": "PH domain-containing family K member 1; membrane bound factor; pleckstrin homology domain containing, family K member 1; rhotekin-2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:170799)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "", "function": "May play an important role in lymphopoiesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BFP3;Q8BFP8;Q8BFQ0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0035556 intracellular signal transduction;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0002250 adaptive immune response;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q14B46-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEL9-1", "uniprot_id": "REM2_MOUSE", "mass": 37367.0, "length": 341, "protein_name": "GTP-binding protein REM 2", "gene_name": "Rem2", "organism": "Mouse", "refseq_name": "GTP-binding protein REM 2 isoform 1", "refseq_ac": "NP_542764", "gene_names_uniprotkb": "Rem2", "gene_names_refseq": "Rem2", "protein_names_uniprotkb": "GTP-binding protein REM 2; Rad and Gem-like GTP-binding protein 2", "protein_names_refseq": "GTP-binding protein REM 2 isoform 1; GTP-binding protein REM 2; rad and Gem-like GTP-binding protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:140743)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17605760;18068949;21750661;27118437;30072381;33300544;38995900", "class_list": "", "function": "Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Nuclear localization of RGK proteins (Rad, Rem, and Rem2) contributes to the suppression of RGK-mediated cell shape remodeling., [RefSeq, PubMed]; Rem2 interacts with CaMKII at synapses and restricts long-term potentiation in hippocampus. Publication Status: Online-Only, [RefSeq, PubMed]; Report that substitution of two key amino acid residues in the Rem2 N terminus (Arg-79 and Arg-80) completely abolishes its ability to inhibit CaMKII, [RefSeq, PubMed]; Study have shown that Rem2 is expressed in a variety of nervous system tissues, but is enriched in the basal ganglia. The function of Rem2 in the basal ganglia is unknown, but may be important for neuronal maturation during development, and/or neuroplasticity in adulthood. Publication Status: Online-Only, [RefSeq, PubMed]; Voltage dependant calcium channels blockade by Rem2 is likely to be controlled by both the localized concentration of membrane phosphorylated phosphatidylinositide lipids and direct 14-3-3 binding to the Rem2 C-terminus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPB1", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VEL9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35230-1", "uniprot_id": "REG3B_MOUSE", "mass": 19476.0, "length": 175, "protein_name": "Regenerating islet-derived protein 3-beta", "gene_name": "Reg3b", "organism": "Mouse", "refseq_name": "regenerating islet-derived protein 3-beta precursor", "refseq_ac": "NP_035166", "gene_names_uniprotkb": "Reg3b; Pap1; Pap", "gene_names_refseq": "HIP; PAP1; Pap; REG-III; Reg3b", "protein_names_uniprotkb": "Regenerating islet-derived protein 3-beta; Pancreatitis-associated protein 1; REG-3-beta; Reg III-beta; Regenerating islet-derived protein III-beta", "protein_names_refseq": "REG-3-beta; RegIII (beta); pancreatitis-associated protein 1; reg III-beta; regenerating islet-derived protein 3-beta precursor; regenerating islet-derived protein 3-beta; regenerating islet-derived protein III-beta", "tax_id": 10090, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); sciatic neuropathy (Disease Ontology:DOID:11446); acute pancreatitis (Disease Ontology:DOID:2913); liver cirrhosis (Disease Ontology:DOID:5082); pneumonia (Disease Ontology:DOID:552); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:18489); (R-MMU-6803157)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21694778;21750661;22252863;34099862;36150609;7679928;9055810", "class_list": "glycogene", "function": "Acts as a hormone in response to different stimuli. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways (PubMed:34099862). In pancreas, is able stimulate cell proliferation (PubMed:34099862)., [UniProtKB, PubMed]; Bactericidal C-type lectin which acts against several intestinal Gram-positive and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues., [UniProtKB, PubMed, PubMed]; Changes in gut microbiome correlate with intestinal barrier dysfunction and inflammation following a 3-day ethanol exposure in aged mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0042834 peptidoglycan binding;GO:0019838 growth factor binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0042588 zymogen granule;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0045177 apical part of cell;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0008284 positive regulation of cell population proliferation;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P35230-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCU6-1", "uniprot_id": "RM04_MOUSE", "mass": 33073.0, "length": 294, "protein_name": "Large ribosomal subunit protein uL4m", "gene_name": "Mrpl4", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL4m isoform 2", "refseq_ac": "NP_075656", "gene_names_uniprotkb": "Mrpl4; MNCb-3848", "gene_names_refseq": "1110017G11Rik; Mrpl4", "protein_names_uniprotkb": "Large ribosomal subunit protein uL4m; 39S ribosomal protein L4, mitochondrial; L4mt; MRP-L4", "protein_names_refseq": "39S ribosomal protein L4, mitochondrial; L4mt; MRP-L4; large ribosomal subunit protein uL4m isoform 2; large ribosomal subunit protein uL4m", "tax_id": 10090, "disease": "", "pathway": " (mmu:66163); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "11279069;21750661;25605945;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q811L8;Q8JZU9;Q9JJB3", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DCU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62421-1", "uniprot_id": "SH3G3_MOUSE", "mass": 38934.0, "length": 347, "protein_name": "Endophilin-A3", "gene_name": "Sh3gl3", "organism": "Mouse", "refseq_name": "endophilin-A3 isoform 1", "refseq_ac": "NP_059096", "gene_names_uniprotkb": "Sh3gl3; Sh3d2c2; Sh3d2c", "gene_names_refseq": "EEN-B2; SH3P13; Sh3d2c2; Sh3d2c; Sh3gl3", "protein_names_uniprotkb": "Endophilin-A3; Endophilin-3; SH3 domain protein 2C; SH3 domain-containing GRB2-like protein 3; SH3p13", "protein_names_refseq": "SH3 domain protein 2 C2; SH3 domain protein 2C; SH3 domain-containing GRB2-like protein 3; endophilin III; endophilin-3; endophilin-A3 isoform 1; endophilin-A3", "tax_id": 10090, "disease": "", "pathway": " (mmu:20408); (R-MMU-182971); (R-MMU-6807004); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;34428180;9630982", "class_list": "", "function": "Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9462, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0B7", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0045666 positive regulation of neuron differentiation;GO:0061024 membrane organization;GO:2000369 regulation of clathrin-dependent endocytosis;GO:1900186 negative regulation of clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q62421-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCA2-1", "uniprot_id": "RT11_MOUSE", "mass": 20208.0, "length": 191, "protein_name": "Small ribosomal subunit protein uS11m", "gene_name": "Mrps11", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mrps11", "gene_names_refseq": "", "protein_names_uniprotkb": "Small ribosomal subunit protein uS11m; 28S ribosomal protein S11, mitochondrial; MRP-S11; S11mt", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11402041;21750661;31219806;37453647", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99JT7;Q99N86", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DCA2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVE8-1", "uniprot_id": "NSD2_MOUSE", "mass": 152253.0, "length": 1365, "protein_name": "Histone-lysine N-methyltransferase NSD2", "gene_name": "Nsd2", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase NSD2 isoform 1", "refseq_ac": "NP_001074571", "gene_names_uniprotkb": "Nsd2; Kiaa1090; Whsc1", "gene_names_refseq": "5830445G22Rik; 9430010A17Rik; C130020C13Rik; D030027O06Rik; D930023B08Rik; MMSET; Nsd2; Whsc1l; Whsc1; mKIAA1090", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase NSD2; 2.1.1.357; MMSET; Multiple myeloma SET domain-containing protein; Nuclear SET domain-containing protein 2; Wolf-Hirschhorn syndrome candidate 1 protein homolog", "protein_names_refseq": "IL5 promoter REII region-binding protein; histone-lysine N-methyltransferase NSD2 isoform 1; multiple myeloma SET domain-containing protein; nuclear SET domain-containing protein 2; probable histone-lysine N-methyltransferase NSD2; trithorax/ash1-related protein 5; wolf-Hirschhorn syndrome candidate 1 protein homolog", "tax_id": 10090, "disease": "Wolf-Hirschhorn syndrome (Disease Ontology:DOID:0050460); Sotos syndrome 1 (Disease Ontology:DOID:0112103); syndrome (Disease Ontology:DOID:225); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:107823); (R-MMU-3214841); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-69473)", "pathway_count": 6, "publication_count": 18, "publication_id_list": "18172012;19483677;21183079;21750661;22872234;23241889;28319045;28528544;30084848;31219806;31636135;32862441;34428180;34887587;38709169;38889281;39390582;9618163", "class_list": "", "function": "Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (By similarity). Mono-, di- and tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2, H3K27me3) (PubMed:18172012). Methylation of histone H3 at 'Lys-27' is controversial (By similarity). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:18172012)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; ISWI chromatin remodeling complexes recruit NSD2 and H3K36me2 in pericentromeric heterochromatin., [RefSeq, PubMed]; Multilevel Regulation of NF-kappaB Signaling by NSD2 Suppresses Kras-Driven Pancreatic Tumorigenesis., [RefSeq, PubMed]; Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3VCH6;Q6ZPY1;Q7TSF5;Q811F0", "ec_number_list": "2.3.2.27;2.1.1.357;4.2.99.18;5.6.2.4;3.4.19.-;2.3.2.23;2.3.2.-;3.6.-.-;2.3.2.26;3.1.3.16;3.1.-.-;2.7.11.1;2.1.1.370;2.1.1.371;1.14.11.69;1.14.11.66;2.3.1.48;2.3.1.-;2.1.1.-;2.1.1.354;2.1.1.359;2.1.1.367", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042054 histone methyltransferase activity;GO:0043565 sequence-specific DNA binding;GO:0046975 histone H3K36 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin;GO:0005694 chromosome", "go_biological_process": "GO:0003290 atrial septum secundum morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0060348 bone development", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8BVE8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P1D5-1", "uniprot_id": "SE6L1_MOUSE", "mass": 104827.0, "length": 963, "protein_name": "Seizure 6-like protein", "gene_name": "Sez6l", "organism": "Mouse", "refseq_name": "seizure 6-like protein isoform 1 precursor", "refseq_ac": "NP_001240845", "gene_names_uniprotkb": "Sez6l; Aig1l; Kiaa0927", "gene_names_refseq": "AIG1; Acig1; BSRP-B; Sez6l; mKIAA0927", "protein_names_uniprotkb": "Seizure 6-like protein; Acupuncture-induced protein 1-L; BSRP-B; Brain-specific receptor-like protein B", "protein_names_refseq": "acupuncture induced gene 1; acupuncture-induced protein 1-L; brain-specific receptor-like protein B; seizure 6-like protein isoform 1 precursor; seizure 6-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:56747)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;16814779;17341691;21750661;30899004;34958451", "class_list": "", "function": "Candidate tumor suppressor gene. May contribute to specialized endoplasmic reticulum functions in neurons., [UniProtKB, PubMed]; The beta-Secretase Substrate Seizure 6-Like Protein (SEZ6L) Controls Motor Functions in Mice., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q3V651;Q499M3;Q6PHN6;Q8C420", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005783 endoplasmic reticulum;GO:0043025 neuronal cell body;GO:0045211 postsynaptic membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:1990051 activation of protein kinase C activity;GO:0021680 cerebellar Purkinje cell layer development;GO:0060074 synapse maturation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q6P1D5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ER99-1", "uniprot_id": "RSCA1_MOUSE", "mass": 61251.0, "length": 582, "protein_name": "Regulatory solute carrier protein family 1 member 1", "gene_name": "Rsc1a1", "organism": "Mouse", "refseq_name": "regulatory solute carrier protein family 1 member 1", "refseq_ac": "NP_076033", "gene_names_uniprotkb": "Rsc1a1", "gene_names_refseq": "1700027M01Rik; Rs1; Rsc1a1", "protein_names_uniprotkb": "Regulatory solute carrier protein family 1 member 1; Regulatory subunit of SGLT1; Transporter regulator RS1; mRS1", "protein_names_refseq": "regulatory solute carrier protein family 1 member 1; regulatory subunit of SGLT1; transporter regulator RS1", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:69994)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;15601832;16024787", "class_list": "", "function": "Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network (By similarity). Regulates the expression of SLC5A1 in a tissue-specific manner and is specifically involved in its regulation in the small intestine., [UniProtKB, PubMed]; Rsc1A1 has a role in Na+-D-glucose cotransport in the small intestine through SGLT1 and in preventing obesity [Rsc1A1], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9868, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AUM1;B2RWX9;Q78HA0;Q9CVU8", "ec_number_list": "", "go_molecular_function": "GO:0019871 sodium channel inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016020 membrane", "go_biological_process": "GO:0010829 negative regulation of D-glucose transmembrane transport;GO:0006351 DNA-templated transcription;GO:0050892 intestinal absorption;GO:1903077 negative regulation of protein localization to plasma membrane;GO:0042997 negative regulation of Golgi to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9ER99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922R5-1", "uniprot_id": "P4R3B_MOUSE", "mass": 93934.0, "length": 820, "protein_name": "Serine/threonine-protein phosphatase 4 regulatory subunit 3B", "gene_name": "Ppp4r3b", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform 1", "refseq_ac": "NP_598795", "gene_names_uniprotkb": "Ppp4r3b; Kiaa1387; Pp4r3b; Smek2", "gene_names_refseq": "Ppp4r3b; Smek2; mKIAA1387", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 4 regulatory subunit 3B; SMEK homolog 2", "protein_names_refseq": "SMEK homolog 2, suppressor of mek1; serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform 1; serine/threonine-protein phosphatase 4 regulatory subunit 3B", "tax_id": 10090, "disease": "", "pathway": " (mmu:104570)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21183079;21423269;21750661;28467410;29180410;31219806;32782141;34428180;36852467", "class_list": "", "function": "Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers (By similarity)., [UniProtKB]; Smek/Mbd3 interaction regulates neuronal gene expression and neuronal differentiation during cortical development. Publication Status: Online-Only, [RefSeq, PubMed]; Smek1 and Smek2 (Smek1/2) are key factors in the Ryk signaling pathway, [RefSeq, PubMed]; The Smek-containing protein phosphatase 4 complex represses transcription of Wnt-responsive development-related genes through histone deacetylation, and that this complex is essential for embryonic stem cell pluripotency maintenance, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0E4;Q5M6V9;Q5RJC0;Q5RJC1;Q6ZPS5;Q8BTK2;Q8BY94;Q8BYY0", "ec_number_list": "", "go_molecular_function": "GO:0072542 protein phosphatase activator activity;GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016607 nuclear speck", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0006974 DNA damage response;GO:0006470 protein dephosphorylation;GO:0045722 positive regulation of gluconeogenesis;GO:2000779 regulation of double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q922R5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTS4-1", "uniprot_id": "NUP54_MOUSE", "mass": 55732.0, "length": 510, "protein_name": "Nuclear pore complex protein Nup54", "gene_name": "Nup54", "organism": "Mouse", "refseq_name": "nuclear pore complex protein Nup54 isoform 2", "refseq_ac": "NP_899248", "gene_names_uniprotkb": "Nup54", "gene_names_refseq": "3110079L04Rik; 54kDa; Nup54", "protein_names_uniprotkb": "Nuclear pore complex protein Nup54; 54 kDa nucleoporin; Nucleoporin Nup54", "protein_names_refseq": "54 kDa nucleoporin; nuclear pore complex protein Nup54 isoform 2; nuclear pore complex protein Nup54; nucleoporin 54kDa; nucleoporin Nup54", "tax_id": 10090, "disease": "dystonia 37, early-onset with striatal lesions (Disease Ontology:DOID:0060956)", "pathway": " (mmu:269113); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885)", "pathway_count": 18, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;20665223;21750661;22872234;25428506;30084848;30779550;31219806;34428180;34887587;36064721;40997131", "class_list": "", "function": "Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSI2;Q8BU42", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0032991 protein-containing complex;GO:0044613 nuclear pore central transport channel", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:0006605 protein targeting;GO:0051028 mRNA transport;GO:0042306 regulation of protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BTS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62264-1", "uniprot_id": "RS14_MOUSE", "mass": 16273.0, "length": 151, "protein_name": "Small ribosomal subunit protein uS11", "gene_name": "Rps14", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS11", "refseq_ac": "NP_065625", "gene_names_uniprotkb": "Rps14", "gene_names_refseq": "2600014J02Rik; Rps14", "protein_names_uniprotkb": "Small ribosomal subunit protein uS11; 40S ribosomal protein S14", "protein_names_refseq": "40S ribosomal protein S14; small ribosomal subunit protein uS11", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); chromosome 5q deletion syndrome (Disease Ontology:DOID:0090016); anemia (Disease Ontology:DOID:2355)", "pathway": " (mmu:20044); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;25605945;31219806;34428180;35820727;35984892;36210013;36288343;36517592;36977657;37453647;37507081;39627609", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, PubMed]; Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P06366;Q544W4", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0048027 mRNA 5'-UTR binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0030218 erythrocyte differentiation;GO:0006412 translation;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P62264-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB85-1", "uniprot_id": "RRP8_MOUSE", "mass": 51066.0, "length": 457, "protein_name": "Ribosomal RNA-processing protein 8", "gene_name": "Rrp8", "organism": "Mouse", "refseq_name": "ribosomal RNA-processing protein 8 isoform 2", "refseq_ac": "NP_080173", "gene_names_uniprotkb": "Rrp8", "gene_names_refseq": "1500003O22Rik; 2900001K19Rik; NML; Rrp8", "protein_names_uniprotkb": "Ribosomal RNA-processing protein 8; 2.1.1.-; Cerebral protein 1 homolog", "protein_names_refseq": "cerebral protein 1 homolog; nucleomethylin protein; ribosomal RNA processing 8, methyltransferase, homolog; ribosomal RNA-processing protein 8 isoform 2; ribosomal RNA-processing protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:101867)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17242355;21183079;21750661;29244083;31219806;34428180", "class_list": "", "function": "Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The suppression of p53 did not rescue the lethality or impaired erythropoiesis of NML-/- embryos, suggesting that p53-independent mechanisms underlie the NML-deficient phenotypes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9X9;Q3TDD7;Q3U3A5;Q8BHW3", "ec_number_list": "", "go_molecular_function": "GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005677 chromatin silencing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0097009 energy homeostasis;GO:0042149 cellular response to glucose starvation;GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DB85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64213-1", "uniprot_id": "SF01_MOUSE", "mass": 70403.0, "length": 653, "protein_name": "Splicing factor 1", "gene_name": "Sf1", "organism": "Mouse", "refseq_name": "splicing factor 1 isoform 1", "refseq_ac": "NP_001104261", "gene_names_uniprotkb": "Sf1; Zfm1; Zfp162", "gene_names_refseq": "BBP; MZFM; Sf1; WBP4; Zfp162", "protein_names_uniprotkb": "Splicing factor 1; BBP; CW17; Mammalian branch point-binding protein; Transcription factor ZFM1; Zinc finger gene in MEN1 locus; Zinc finger protein 162; mBBP; mZFM", "protein_names_refseq": "mammalian branch point-binding protein; splicing factor 1 isoform 1; transcription factor ZFM1; zinc finger gene in MEN1 locus; zinc finger protein 162", "tax_id": 10090, "disease": "ischemia (Disease Ontology:DOID:326)", "pathway": " (mmu:22668); (R-MMU-72163)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10360842;17242355;19131326;19144319;21183079;21750661;22517741;26495903;28135057;28528544;29125738;29237092;34428180;34678516;34887587;36288343;36852467;40021952;40885482;9212169", "class_list": "", "function": "Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9QK02;O08817;P70167;Q61454;Q921Z4", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0045131 pre-mRNA branch point binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0048662 negative regulation of smooth muscle cell proliferation;GO:0033327 Leydig cell differentiation;GO:0000398 mRNA splicing, via spliceosome;GO:0030238 male sex determination", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q64213-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQI3-1", "uniprot_id": "OTUB1_MOUSE", "mass": 31270.0, "length": 271, "protein_name": "Ubiquitin thioesterase OTUB1", "gene_name": "Otub1", "organism": "Mouse", "refseq_name": "ubiquitin thioesterase OTUB1", "refseq_ac": "NP_598911", "gene_names_uniprotkb": "Otub1", "gene_names_refseq": "Otub1", "protein_names_uniprotkb": "Ubiquitin thioesterase OTUB1; 3.4.19.12; Deubiquitinating enzyme OTUB1; OTU domain-containing ubiquitin aldehyde-binding protein 1; Otubain-1; Ubiquitin-specific-processing protease OTUB1", "protein_names_refseq": "OTU domain-containing ubiquitin aldehyde-binding protein 1; deubiquitinating enzyme OTUB1; otubain 1; ubiquitin thioesterase OTUB1; ubiquitin-specific-processing protease OTUB1", "tax_id": 10090, "disease": "lupus nephritis (Disease Ontology:DOID:0080162); IgA glomerulonephritis (Disease Ontology:DOID:2986)", "pathway": " (mmu:107260); (R-MMU-5689880); (R-MMU-5689896)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "14661020;17242355;21540332;21750661;22645316;25153642;25428506;28135057;28528544;30084848;33300544;34428180;37024477;37775718;38270191;38644399", "class_list": "", "function": "Deubiquitylating Enzyme OTUB1 Facilitates Neuronal Survival After Intracerebral Hemorrhage Via Inhibiting NF-kappaB-triggered Apoptotic Cascades., [RefSeq, PubMed]; Hydrolase that can specifically remove compared to 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation (By similarity). Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen (PubMed:14661020). Acts via its interaction with RNF128/GRAIL (PubMed:14661020). Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128 (PubMed:14661020). Deubiquitinates estrogen receptor alpha (ESR1) (By similarity). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains (By similarity). Not able to cleave di-ubiquitin (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a key non-catalytic role in DNA repair regulation by inhibiting activity of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites. Inhibits RNF168 independently of ubiquitin thioesterase activity by binding and inhibiting UBE2N/UBC13, the E2 partner of RNF168, thereby limiting spreading of 'Lys-63'-linked histone H2A and H2AX marks. Inhibition occurs by binding to free ubiquitin: free ubiquitin acts as an allosteric regulator that increases affinity for UBE2N/UBC13 and disrupts interaction with UBE2V1. The OTUB1-UBE2N/UBC13-free ubiquitin complex adopts a configuration that mimics a cleaved 'Lys48'-linked di-ubiquitin chain. Acts as a regulator of mTORC1 and mTORC2 complexes. When phosphorylated at Tyr-26, acts as an activator of the mTORC1 complex by mediating deubiquitination of RPTOR via a non-catalytic process: acts by binding and inhibiting the activity of the ubiquitin-conjugating enzyme E2 (UBE2D1/UBCH5A, UBE2W/UBC16 and UBE2N/UBC13), thereby preventing ubiquitination of RPTOR. Can also act as an inhibitor of the mTORC1 and mTORC2 complexes in response to amino acids by mediating non-catalytic deubiquitination of DEPTOR., [UniProtKB, UniProtKB]; Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRbeta., [RefSeq, PubMed]; The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the gamma-Subunit Gng2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ULV9;Q3V408;Q8C326;Q8R5F2", "ec_number_list": "2.3.2.24;2.3.2.23;2.3.2.27;3.4.19.12;3.6.5.2", "go_molecular_function": "GO:0019784 deNEDDylase activity;GO:0031625 ubiquitin protein ligase binding;GO:0043130 ubiquitin binding;GO:0055105 ubiquitin-protein transferase inhibitor activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:2000780 negative regulation of double-strand break repair;GO:0006281 DNA repair;GO:0016579 protein deubiquitination;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q7TQI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VE38-1", "uniprot_id": "OXND1_MOUSE", "mass": 34727.0, "length": 311, "protein_name": "Oxidoreductase NAD-binding domain-containing protein 1", "gene_name": "Oxnad1", "organism": "Mouse", "refseq_name": "oxidoreductase NAD-binding domain-containing protein 1 precursor", "refseq_ac": "NP_663435", "gene_names_uniprotkb": "Oxnad1", "gene_names_refseq": "2410002F01Rik; Oxnad1", "protein_names_uniprotkb": "Oxidoreductase NAD-binding domain-containing protein 1; 1.-.-.-", "protein_names_refseq": "oxidoreductase NAD-binding domain-containing protein 1 precursor; oxidoreductase NAD-binding domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:218885)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UT09;Q8C093", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VE38-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35435-1", "uniprot_id": "PYRD_MOUSE", "mass": 42700.0, "length": 395, "protein_name": "Dihydroorotate dehydrogenase (quinone), mitochondrial", "gene_name": "Dhodh", "organism": "Mouse", "refseq_name": "dihydroorotate dehydrogenase (quinone), mitochondrial precursor", "refseq_ac": "NP_064430", "gene_names_uniprotkb": "Dhodh", "gene_names_refseq": "2810417D19Rik; Dhodh", "protein_names_uniprotkb": "Dihydroorotate dehydrogenase (quinone), mitochondrial; 1.3.5.2; DHOdehase; Dihydroorotate oxidase", "protein_names_refseq": "DHOdehase; dihydroorotate dehydrogenase (quinone), mitochondrial precursor; dihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate dehydrogenase, mitochondrial; dihydroorotate oxidase", "tax_id": 10090, "disease": "postaxial acrofacial dysostosis (Disease Ontology:DOID:0111259)", "pathway": " (mmu:56749); (R-MMU-500753)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12100469;21750661;31047779;37579695", "class_list": "", "function": "Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Immunosuppressive agent HR325 (an inhibitor of dihydroorotate dehydrogenase, DHODH) inhibits immunoglobulin (Ig) secretion both in vitro and in vivo and that this effect can be reverse with exogenous uridine, [RefSeq, PubMed]; Knockdown of Dhodh reduced hippocampus mean firing rate., [RefSeq, PubMed]; Targeting DHODH reveals therapeutic opportunities in ATRA-resistant acute promyelocytic leukemia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.3.5.2", "go_molecular_function": "GO:0004151 dihydroorotase activity;GO:0048038 quinone binding;GO:0010181 FMN binding;GO:0004152 dihydroorotate dehydrogenase activity;GO:0048039 ubiquinone binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0043025 neuronal cell body", "go_biological_process": "GO:0090140 regulation of mitochondrial fission;GO:0009220 pyrimidine ribonucleotide biosynthetic process;GO:0043065 positive regulation of apoptotic process;GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0044205 'de novo' UMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35435-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LJ7-1", "uniprot_id": "RCBT2_MOUSE", "mass": 60164.0, "length": 551, "protein_name": "RCC1 and BTB domain-containing protein 2", "gene_name": "Rcbtb2", "organism": "Mouse", "refseq_name": "RCC1 and BTB domain-containing protein 2", "refseq_ac": "NP_001164165", "gene_names_uniprotkb": "Rcbtb2; Chc1l", "gene_names_refseq": "2610028E02Rik; 2810420M18Rik; Chc1l; RC/BTB2; Rcbtb2", "protein_names_uniprotkb": "RCC1 and BTB domain-containing protein 2; Chromosome condensation 1-like; Regulator of chromosome condensation and BTB domain-containing protein 2", "protein_names_refseq": "RCC1 and BTB domain-containing protein 2; regulator of chromosome condensation and BTB domain-containing protein 2", "tax_id": 10090, "disease": "malignant histiocytic disease (Disease Ontology:DOID:2570)", "pathway": " (mmu:105670)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;22768142;25428506;25762510;34428180", "class_list": "", "function": "Findings suggest that RC/BTB2 is a necessary component of the process of formation of primary cilia in somatic cells, perhaps through the transportation of cargos from Golgi bodies to centrosomes for cilia assembling., [RefSeq, PubMed]; The expression and localization of mouse RC/BTB2 in the testis and male germ cells, was characterized., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G1EE51;Q3TUA3;Q8BMG2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0001889 liver development;GO:0008283 cell population proliferation;GO:0048536 spleen development;GO:0048565 digestive tract development;GO:0048535 lymph node development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99LJ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YR5-1", "uniprot_id": "SAFB2_MOUSE", "mass": 111838.0, "length": 991, "protein_name": "Scaffold attachment factor B2", "gene_name": "Safb2", "organism": "Mouse", "refseq_name": "scaffold attachment factor B2 isoform 1", "refseq_ac": "NP_001025150", "gene_names_uniprotkb": "Safb2", "gene_names_refseq": "Safb2; mKIAA0138", "protein_names_uniprotkb": "Scaffold attachment factor B2; SAF-B2", "protein_names_refseq": "SAF-B2; scaffold attachment factor B2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:224902)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18250455;21183079;21750661;24129315;25153642;26092125;26495903;28528544", "class_list": "", "function": "Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation (By similarity)., [UniProtKB]; Despite a high degree of sequence similarity, SAFB1(-/-) and SAFB2(-/-) mice do not totally phenocopy each other, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K153", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0060765 regulation of androgen receptor signaling pathway;GO:0060008 Sertoli cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q80YR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q924W9-1", "uniprot_id": "RBTN1_MOUSE", "mass": 17805.0, "length": 156, "protein_name": "Rhombotin-1", "gene_name": "Lmo1", "organism": "Mouse", "refseq_name": "rhombotin-1 isoform 2", "refseq_ac": "NP_001289134", "gene_names_uniprotkb": "Lmo1; Rbtn1; Rhom1; Ttg1", "gene_names_refseq": "Lmo1; Rbtn-1; Rbtn1; Ttg1", "protein_names_uniprotkb": "Rhombotin-1; Cysteine-rich protein TTG-1; LIM domain only protein 1; LMO-1; T-cell translocation protein 1", "protein_names_refseq": "LIM domain only protein 1; LIM only 1; T-cell translocation protein 1; cysteine-rich protein TTG-1; rhombotin-1 isoform 2; rhombotin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:109594); (R-MMU-8939236)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11528126;1703797;21750661", "class_list": "", "function": "May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0046013 regulation of T cell homeostatic proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q924W9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C3B8-1", "uniprot_id": "RFT1_MOUSE", "mass": 60303.0, "length": 541, "protein_name": "Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1", "gene_name": "Rft1", "organism": "Mouse", "refseq_name": "man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 isoform 1", "refseq_ac": "NP_808483", "gene_names_uniprotkb": "Rft1", "gene_names_refseq": "D930025H04; Rft1", "protein_names_uniprotkb": "Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1; Protein RFT1 homolog", "protein_names_refseq": "man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 isoform 1; man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1; protein RFT1 homolog", "tax_id": 10090, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation In (Disease Ontology:DOID:0080566); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:328370)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "glycogene", "function": "Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues (By similarity). However, the intramembrane lipid transporter activity could not be confirmed in vitro (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RUN9", "ec_number_list": "", "go_molecular_function": "GO:0034202 glycolipid floppase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation;GO:0034203 glycolipid translocation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C3B8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q75NR7-1", "uniprot_id": "RECQ4_MOUSE", "mass": 135124.0, "length": 1216, "protein_name": "ATP-dependent DNA helicase Q4", "gene_name": "Recql4", "organism": "Mouse", "refseq_name": "ATP-dependent DNA helicase Q4 isoform 1", "refseq_ac": "NP_478121", "gene_names_uniprotkb": "Recql4; Recq4", "gene_names_refseq": "RecQ4; Recql4", "protein_names_uniprotkb": "ATP-dependent DNA helicase Q4; 5.6.2.4; DNA 3'-5' helicase RecQ4; DNA helicase, RecQ-like type 4; RecQ protein-like 4; RecQ4", "protein_names_refseq": "ATP-dependent DNA helicase Q4 isoform 1; ATP-dependent DNA helicase Q4; DNA 3'-5' helicase RecQ4; DNA helicase, RecQ-like type 4; RecQ helicase protein-like 4", "tax_id": 10090, "disease": "Baller-Gerold syndrome (Disease Ontology:DOID:0050654); rapadilino syndrome (Disease Ontology:DOID:0050774); Rothmund-Thomson syndrome (Disease Ontology:DOID:2732)", "pathway": " (mmu:79456)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11167012;12915449;12952869;15703196;16600186;20485683;21750661;25428506;31219806;31276497;34117297", "class_list": "", "function": "An ATP-dependent DNA helicase which unwinds dsDNA with a 3'-overhang in a 3'-5' direction (By similarity). May play a role in development of the palate and the limbs. May modulate chromosome segregation., [UniProtKB, UniProtKB, PubMed, PubMed]; Comparison of the fertility of tumor suppressor gene-deficient C57BL/6 mouse strains reveals stable reproductive aging and novel pleiotropic gene. Publication Status: Online-Only, [RefSeq, PubMed]; Recql4 functions as a regulatory protein during osteoprogenitor proliferation, a critical cellular event during skeleton development., [RefSeq, PubMed]; Recql4-deficient mice show growth retardation and skin abnormalities., [RefSeq, PubMed]; Study has demonstrated the ATP-dependent helicase activity of Recql4 is not physiologically essential for murine embryonic development or adult homeostasis, cellular replication and physiological DNA damage repair. However, mutations that create truncating proteins are not tolerated. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q76MT1;Q99PV9", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0032357 oxidized purine DNA binding;GO:0043138 3'-5' DNA helicase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005694 chromosome;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0045875 negative regulation of sister chromatid cohesion;GO:0008284 positive regulation of cell population proliferation;GO:0000723 telomere maintenance;GO:0001501 skeletal system development;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q75NR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZWU9-1", "uniprot_id": "RS27_MOUSE", "mass": 9461.0, "length": 84, "protein_name": "Small ribosomal subunit protein eS27", "gene_name": "Rps27", "organism": "Mouse", "refseq_name": "ribosomal protein S27-like", "refseq_ac": "NP_001177187", "gene_names_uniprotkb": "Rps27", "gene_names_refseq": "Gm9846; Rps27l2; Rps27rt; Rps27", "protein_names_uniprotkb": "Small ribosomal subunit protein eS27; 40S ribosomal protein S27", "protein_names_refseq": "40S ribosomal protein S27; ribosomal protein S27-like", "tax_id": 10090, "disease": "Diamond-Blackfan anemia 17 (Disease Ontology:DOID:0111880)", "pathway": " (mmu:100043813); (mmu:57294); (R-MMU-141430); (R-MMU-141444); (R-MMU-156827); (R-MMU-1799339); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-6791226); (R-MMU-68877); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-9648025); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 21, "publication_count": 7, "publication_id_list": "17242355;21183079;21750661;34428180;35820727;36517592;37453647", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Required for proper rRNA processing and maturation of 18S rRNAs (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLE3", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis;GO:0000028 ribosomal small subunit assembly;GO:0140236 translation at presynapse;GO:0140242 translation at postsynapse", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6ZWU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U680-1", "uniprot_id": "SAMC_MOUSE", "mass": 29027.0, "length": 274, "protein_name": "Mitochondrial S-adenosylmethionine carrier protein", "gene_name": "Slc25a26", "organism": "Mouse", "refseq_name": "mitochondrial S-adenosylmethionine carrier protein", "refseq_ac": "NP_080531", "gene_names_uniprotkb": "Slc25a26; Samc", "gene_names_refseq": "4930433D19Rik; 4933433F13Rik; D6Bwg0781e; Slc25a26; Slc25a6", "protein_names_uniprotkb": "Mitochondrial S-adenosylmethionine carrier protein; SAM carrier; Solute carrier family 25 member 26", "protein_names_refseq": "S-adenosylmethionine mitochondrial carrier protein; SAM carrier; mitochondrial S-adenosylmethionine carrier protein; mitochondrial S-adenosylmethionine transporter; solute carrier family 25 member 26", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 28 (Disease Ontology:DOID:0111470)", "pathway": " (mmu:67582); (R-MMU-549127)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;31219806;35464759;37507081", "class_list": "", "function": "Aberrant Expression of Mitochondrial SAM Transporter SLC25A26 Impairs Oocyte Maturation and Early Development in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial S-adenosyl-L-methionine/S-adenosyl-L-homocysteine antiporter. Mediates the exchange of cytosolic S-adenosyl-L-methionine, the predominant methyl-group donor for macromolecule methylation processes, for mitochondrial S-adenosylhomocysteine(SAH), a by-product of methylation reactions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JZT2", "ec_number_list": "", "go_molecular_function": "GO:0000095 S-adenosyl-L-methionine transmembrane transporter activity;GO:0180003 S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0015805 S-adenosyl-L-methionine transport;GO:0043414 macromolecule methylation;GO:1990543 mitochondrial S-adenosyl-L-methionine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5U680-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D300-1", "uniprot_id": "RGF1C_MOUSE", "mass": 52723.0, "length": 466, "protein_name": "Ras-GEF domain-containing family member 1C", "gene_name": "Rasgef1c", "organism": "Mouse", "refseq_name": "ras-GEF domain-containing family member 1C isoform 1", "refseq_ac": "NP_001334391", "gene_names_uniprotkb": "Rasgef1c", "gene_names_refseq": "9130006A14Rik; Rasgef1c", "protein_names_uniprotkb": "Ras-GEF domain-containing family member 1C", "protein_names_refseq": "ras-GEF domain-containing family member 1C isoform 1; ras-GEF domain-containing family member 1C", "tax_id": 10090, "disease": "", "pathway": " (mmu:74563)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30084848", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BYJ7", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007265 Ras protein signal transduction;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D300-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1M0-1", "uniprot_id": "P2RX7_MOUSE", "mass": 68388.0, "length": 595, "protein_name": "P2X purinoceptor 7", "gene_name": "P2rx7", "organism": "Mouse", "refseq_name": "P2X purinoceptor 7 isoform a", "refseq_ac": "NP_035157", "gene_names_uniprotkb": "P2rx7; P2x7", "gene_names_refseq": "P2X(7); P2X7R; P2rx7", "protein_names_uniprotkb": "P2X purinoceptor 7; ATP receptor; P2X7; P2Z receptor; Purinergic receptor", "protein_names_refseq": "ATP receptor; P2X purinoceptor 7 isoform a; P2X purinoceptor 7; P2X7 purinoceptor; P2X7 receptor; P2Z receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:18439); (R-MMU-139853); (R-MMU-418346); (R-MMU-844456)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11016935;17928361;19349973;20947763;21750661;25281740;26572062;26877061;29958799;30899004;9849870", "class_list": "", "function": "ATP-gated nonselective transmembrane cation channel. Requires high millimolar-range concentrations of ATP to become activated (PubMed:9849870). ATP binding trigers the rapid opening of the channel and allows Na(+) and Ca(2+) influx and K(+) efflux (By similarity). Has also the ability to form a large pore in the cell membrane, allowing the passage of large cationic molecules (PubMed:25281740). In microglia, may mediate NADPH transport across the plasma membrane (By similarity). In immune cells, P2RX7 acts as a molecular sensor in pathological inflammatory states by detecting and responding to high local concentrations of extracellar ATP. In microglial cells, P2RX7 activation leads to the release of pro-inflammatory cytokines, such as IL-1beta and IL-18, through the activation of the NLRP3 inflammasome and caspase-1 (PubMed:26877061). Cooperates with KCNK6 to activate NLRP3 inflammasome (PubMed:29958799). Activates death pathways leading to apoptosis and autophagy (By similarity). Activates death pathways leading to pyroptosis (PubMed:26572062). Involved in the homeostatic wound healing response to tissue injury, a multistep cascade that guides neutrophil migration to necrotic sites while avoiding collateral damage of healthy tissues. Senses ATP released from necrotic cells triggering activation of NLRP3 inflammasome and neutrophil adhesion to the vascular endothelium close to the injury site., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Receptor for ATP that acts as a ligand-gated ion channel., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3ULZ7", "ec_number_list": "1.8.-.-;2.7.11.1", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane", "go_biological_process": "GO:0032730 positive regulation of interleukin-1 alpha production;GO:0071359 cellular response to dsRNA;GO:0051495 positive regulation of cytoskeleton organization;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q9Z1M0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PGA0-1", "uniprot_id": "RCOR3_MOUSE", "mass": 49779.0, "length": 451, "protein_name": "REST corepressor 3", "gene_name": "Rcor3", "organism": "Mouse", "refseq_name": "REST corepressor 3 isoform b", "refseq_ac": "NP_001277207", "gene_names_uniprotkb": "Rcor3", "gene_names_refseq": "4921514E24Rik; C730034D20Rik; E130101E15Rik; Rcor3", "protein_names_uniprotkb": "REST corepressor 3", "protein_names_refseq": "REST corepressor 3 isoform b", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:214742)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;24129315;24843136", "class_list": "", "function": "In mature erythroid cells, a strong upsurge in Rcor3 and a sharp decline in Rcor1 levels counteract LSD1/Rcor1/2-mediated differentiation., [RefSeq, PubMed]; May act as a component of a corepressor complex that represses transcription., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0017053 transcription repressor complex;GO:0005667 transcription regulator complex;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PGA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WT8-1", "uniprot_id": "RBM47_MOUSE", "mass": 64062.0, "length": 590, "protein_name": "RNA-binding protein 47", "gene_name": "Rbm47", "organism": "Mouse", "refseq_name": "RNA-binding protein 47 isoform a", "refseq_ac": "NP_001120854", "gene_names_uniprotkb": "Rbm47", "gene_names_refseq": "9530077J19Rik; Rbm47", "protein_names_uniprotkb": "RNA-binding protein 47; RNA-binding motif protein 47", "protein_names_refseq": "RNA-binding protein 47 isoform a; RNA-binding protein 47", "tax_id": 10090, "disease": "", "pathway": " (mmu:245945)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "21750661;23649762;24129315;24916387;25428506;26789794;29844590;30084848;30309881;30779550;30844405;31599954;34203471;34428180;34499322;35986129;36852467;37014710;40997131", "class_list": "", "function": "Post-transcriptional regulator Rbm47 elevates IL-10 production and promotes the immunosuppression of B cells., [RefSeq, PubMed]; RBM47 and APOBEC1 constitute the basic machinery for C to U RNA editing., [RefSeq, PubMed]; RBM47 is a Critical Regulator of Mouse Embryonic Stem Cell Differentiation., [RefSeq, PubMed]; RBM47 regulates intestinal injury and tumorigenesis by modifying proliferation, oxidative response, and inflammatory pathways. Publication Status: Online-Only, [RefSeq, PubMed]; RNA binding motif 47 (RBM47): emerging roles in vertebrate development, RNA editing and cancer. Review article, [RefSeq, PubMed]; RNA-binding protein Rbm47 binds to Nanog in mouse embryonic stem cells., [RefSeq, PubMed]; Single-stranded RNA-binding protein that functions in a variety of RNA processes, including alternative splicing, RNA stabilization, and RNA editing. Functions as an enzyme-substrate adapter for the cytidine deaminase APOBEC1. With APOBEC1 forms an mRNA editing complex involved into cytidine to uridine editing of a variety of mRNA molecules (PubMed:24916387, PubMed:30309881, PubMed:30844405). Through the binding of their 3'UTR, also stabilizes a variety of mRNAs and regulates the expression of genes such as the interferon alpha/beta receptor and interleukin-10 (PubMed:29844590). Also involved in the alternative splicing of several genes including TJP1. Binds the pre-mRNA (U)GCAUG consensus sequences in downstream intronic regions of alternative exons, regulating their exclusion and inclusion into mRNAs (By similarity). Independently of its RNA-binding activity, could negatively regulate MAVS by promoting its lysosomal degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Study demonstrated that Rbm47 function is required in the embryo proper, and not the visceral endoderm, for viability and growth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQC7;Q8BZE8", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019899 enzyme binding;GO:0003730 mRNA 3'-UTR binding;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030895 apolipoprotein B mRNA editing enzyme complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0016554 cytidine to uridine editing;GO:0008380 RNA splicing;GO:0034383 low-density lipoprotein particle clearance;GO:0070935 3'-UTR-mediated mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q91WT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2Q4-1", "uniprot_id": "RRF2M_MOUSE", "mass": 86109.0, "length": 779, "protein_name": "Ribosome-releasing factor 2, mitochondrial", "gene_name": "Gfm2", "organism": "Mouse", "refseq_name": "ribosome-releasing factor 2, mitochondrial isoform 2", "refseq_ac": "NP_001139515", "gene_names_uniprotkb": "Gfm2; EFG2; Efg2; GFM2", "gene_names_refseq": "6530419G12Rik; A930009M04Rik; EF-G2mt; EFG2; Gfm2; MST027; RRF2mt", "protein_names_uniprotkb": "Ribosome-releasing factor 2, mitochondrial; 3.6.5.-; EF-G2mt; Elongation factor G 2, mitochondrial; RRF2mt; mEF-G 2", "protein_names_refseq": "ribosome-releasing factor 2, mitochondrial isoform 2; ribosome-releasing factor 2, mitochondrial", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 39 (Disease Ontology:DOID:0111475)", "pathway": " (mmu:320806); (R-MMU-5419276)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;31219806;34428180;36472247;37507081", "class_list": "", "function": "Gut colonization by Bacteroides requires translation by an EF-G paralog lacking GTPase activity., [RefSeq, PubMed]; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RR55;Q8BXS5", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-;3.1.1.29", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0032790 ribosome disassembly;GO:0032543 mitochondrial translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R2Q4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62492-1", "uniprot_id": "RB11A_MOUSE", "mass": 24394.0, "length": 216, "protein_name": "Ras-related protein Rab-11A", "gene_name": "Rab11a", "organism": "Mouse", "refseq_name": "ras-related protein Rab-11A", "refseq_ac": "NP_059078", "gene_names_uniprotkb": "Rab11a; Rab11", "gene_names_refseq": "Rab11a", "protein_names_uniprotkb": "Ras-related protein Rab-11A; 3.6.5.2; Rab-11", "protein_names_refseq": "rab-11; ras-related protein Rab-11A", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (mmu:53869); (R-MMU-432040); (R-MMU-5620912); (R-MMU-5620916); (R-MMU-8854214); (R-MMU-8873719)", "pathway_count": 6, "publication_count": 22, "publication_id_list": "10708602;15292201;17509819;19144319;20190753;20826437;21291502;21750661;25605945;26506309;26740625;28384198;29514919;30084848;31219806;33300544;34428180;36210013;37737843;37770900;37828378;38294869", "class_list": "", "function": "CRB3 navigates Rab11 trafficking vesicles to promote gammaTuRC assembly during ciliogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Rab11 regulates autophagy at dendritic spines in an mTOR- and NMDA-dependent manner., [RefSeq, PubMed]; Rab11a in the spinal cord: an essential contributor to complete Freund's adjuvant-induced inflammatory pain in mice. Publication Status: Online-Only, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB25 regulates epithelial cell differentiation, proliferation and survival, thereby playing key roles in tumorigenesis. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P24410;Q3V1Z6;Q9JLX1", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;2.7.11.1;3.6.1.5;2.7.11.11;3.6.4.10;2.7.11.22;2.7.11.23;3.6.5.4;3.6.5.5;2.5.1.60;3.6.4.-;3.6.1.-;2.7.11.21;3.6.1.15;3.6.-.-;2.7.11.26", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0046872 metal ion binding;GO:0031489 myosin V binding", "go_cellular_component": "GO:0005828 kinetochore microtubule;GO:0098978 glutamatergic synapse;GO:0098837 postsynaptic recycling endosome;GO:0000139 Golgi membrane;GO:0000922 spindle pole", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:1903438 positive regulation of mitotic cytokinetic process;GO:1990182 exosomal secretion;GO:0051223 regulation of protein transport;GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P62492-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TMJ8-1", "uniprot_id": "P3IP1_MOUSE", "mass": 28567.0, "length": 264, "protein_name": "Phosphoinositide-3-kinase-interacting protein 1", "gene_name": "Pik3ip1", "organism": "Mouse", "refseq_name": "phosphoinositide-3-kinase-interacting protein 1 precursor", "refseq_ac": "NP_835362", "gene_names_uniprotkb": "Pik3ip1; Crkd; Hgfl", "gene_names_refseq": "1500004A08Rik; 5830455E04Rik; Crkd; Hgfl; Pik3ip1", "protein_names_uniprotkb": "Phosphoinositide-3-kinase-interacting protein 1; Calcineurin-regulated kringle domain-containing protein; Kringle domain-containing protein HGFL", "protein_names_refseq": "calcineurin-regulated kringle domain protein; calcineurin-regulated kringle domain-containing protein; kringle domain-containing protein HGFL; phosphoinositide-3-kinase-interacting protein 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:216505)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18632611;21750661;22935140;25826393;26495903;31350312;32887751;36179018", "class_list": "", "function": "Data suggest that that neural progenitors are particularly vulnerable to FOXO3-induced apoptosis, which is mediated by PIK3IP1, a negative PI3 kinase regulator., [RefSeq, PubMed]; Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity., [UniProtKB, PubMed]; PIK3IP1 Promotes Extrafollicular Class Switching in T-Dependent Immune Responses., [RefSeq, PubMed]; PIK3IP1 is an important regulator of PI3K in vivo, and its dysregulation can contribute to liver carcinogenesis, [RefSeq, PubMed]; Pik3ip1 Is a Negative Immune Regulator that Inhibits Antitumor T-Cell Immunity. Erratum:[Clin Cancer Res. 2022 May 13;28(10):2197. doi: 10.1158/1078-0432.CCR-22-1109. PMID: 35553648], [RefSeq, PubMed]; Pik3ip1 plays a compensatory negative role for physiologic cardiac hypertrophy. Collectively, our results elucidate the mechanisms for the roles of Pik3ip1 in PI3K/AKT signaling pathway Publication Status: Online-Only, [RefSeq, PubMed]; Regulation of autoimmune disease progression by Pik3ip1 through metabolic reprogramming in T cells and therapeutic implications., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTD5;Q5NBY3;Q5NBY4;Q5NBY6;Q811Z2;Q811Z3", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0005102 signaling receptor binding;GO:0141039 phosphatidylinositol 3-kinase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TMJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ04-1", "uniprot_id": "OGFD2_MOUSE", "mass": 39270.0, "length": 349, "protein_name": "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2", "gene_name": "Ogfod2", "organism": "Mouse", "refseq_name": "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 isoform 1", "refseq_ac": "NP_079947", "gene_names_uniprotkb": "Ogfod2", "gene_names_refseq": "1300006G11Rik; 5730405M13Rik; Ogfod2", "protein_names_uniprotkb": "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2; 1.14.11.-", "protein_names_refseq": "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 isoform 1; 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66627)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q78IV7;Q8BMW3", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0051213 dioxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQ04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2L5-1", "uniprot_id": "RT18C_MOUSE", "mass": 16275.0, "length": 143, "protein_name": "Small ribosomal subunit protein bS18m", "gene_name": "Mrps18c", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein bS18m", "refseq_ac": "NP_081102", "gene_names_uniprotkb": "Mrps18c", "gene_names_refseq": "1110037D14Rik; Mrps18c", "protein_names_uniprotkb": "Small ribosomal subunit protein bS18m; 28S ribosomal protein S18-1, mitochondrial; 28S ribosomal protein S18c, mitochondrial; MRP-S18-1; MRP-S18-c; Mrps18-c; S18mt-c", "protein_names_refseq": "28S ribosomal protein S18-1, mitochondrial; 28S ribosomal protein S18c, mitochondrial; MRP-S18-1; MRP-S18-c; S18mt-c; mrps18-c; small ribosomal subunit protein bS18m", "tax_id": 10090, "disease": "", "pathway": " (mmu:68735); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKN5;Q9D100", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070181 small ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R2L5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P2L6-1", "uniprot_id": "NSD3_MOUSE", "mass": 161002.0, "length": 1439, "protein_name": "Histone-lysine N-methyltransferase NSD3", "gene_name": "Nsd3", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase NSD3 isoform 1", "refseq_ac": "NP_001001735", "gene_names_uniprotkb": "Nsd3; Whsc1l1", "gene_names_refseq": "6720429E03; A530023P05; Nsd3; WHISTLE; Whsc1l1", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase NSD3; 2.1.1.370; 2.1.1.371; Nuclear SET domain-containing protein 3; WHSC1-like protein 1; Wolf-Hirschhorn syndrome candidate 1-like protein 1 homolog", "protein_names_refseq": "WHSC1-like protein 1; histone-lysine N-methyltransferase NSD3 isoform 1; histone-lysine N-methyltransferase NSD3; nuclear SET domain-containing protein 3; wolf-Hirschhorn syndrome candidate 1-like protein 1 homolog", "tax_id": 10090, "disease": "Sotos syndrome 1 (Disease Ontology:DOID:0112103); syndrome (Disease Ontology:DOID:225); myeloid leukemia (Disease Ontology:DOID:8692)", "pathway": " (mmu:234135); (R-MMU-3214841)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;21750661;23806337;25428506;29101251;30084848;30779550;31219806;34428180;36210013;37748280;37828378;39390582;40885482;40997131", "class_list": "", "function": "Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the SET domain family of histone lysine N-methyltransferase proteins. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. It acts in opposition to the histone demethylase Jmjd1c. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2015]., [RefSeq]; This study reveals a critical role of NSD3-mediated IRF3 methylation in enhancing antiviral innate immunity., [RefSeq, PubMed]; WHSC1L1-mediated epigenetic downregulation of VMP1 participates in herpes simplex virus 1 infection-induced mitophagy impairment and neuroinflammation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDS4;Q3U0L8;Q3V131;Q8BJT3", "ec_number_list": "2.1.1.364;2.1.1.-;2.1.1.370;2.1.1.371;2.1.1.357;2.1.1.85;2.1.1.354", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042800 histone H3K4 methyltransferase activity;GO:0046975 histone H3K36 methyltransferase activity;GO:0046976 histone H3K27 methyltransferase activity;GO:0140537 transcription regulator activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q6P2L6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C0HKG5-1", "uniprot_id": "RNT2A_MOUSE", "mass": 29609.0, "length": 259, "protein_name": "Ribonuclease T2-A", "gene_name": "Rnaset2a; Rnaset2b", "organism": "Mouse", "refseq_name": "ribonuclease T2-A isoform 1 precursor", "refseq_ac": "NP_001077407", "gene_names_uniprotkb": "Rnaset2a; Rnaset2b; Rnase6pl", "gene_names_refseq": "0610007O07Rik; 4833423A10Rik; 4930532K22Rik; RNASE6PL; Rnaset2a; Rnaset2", "protein_names_uniprotkb": "Ribonuclease T2-A; 4.6.1.19; Ribonuclease 6-A", "protein_names_refseq": "ribonuclease 6-A; ribonuclease 6; ribonuclease T2-A isoform 1 precursor; ribonuclease T2-A; ribonuclease T2", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); RNASET2-deficient cystic leukoencephalopathy (Disease Ontology:DOID:0081007); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); lung cancer (Disease Ontology:DOID:1324); melanoma (Disease Ontology:DOID:1909); colon adenocarcinoma (Disease Ontology:DOID:234); gastric adenocarcinoma (Disease Ontology:DOID:3717); Lynch syndrome (Disease Ontology:DOID:3883); pulmonary neuroendocrine tumor (Disease Ontology:DOID:5410)", "pathway": " (mmu:100037283); (mmu:68195); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;34428180;37633478", "class_list": "", "function": "Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis., [RefSeq, PubMed]; Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. In plasmacytoid dendritic cells, it cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA fragments and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP), a potent stimulatory ligand for TLR7. Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 2, "disease_count": 9, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQ01", "ec_number_list": "4.6.1.19;1.11.1.27;3.1.1.4;2.3.1.23;3.2.1.24;4.6.1.18;3.2.1.17;1.11.2.2;3.2.1.31;3.4.16.5;3.4.16.-;3.2.1.52;3.2.1.23;3.4.21.20;2.7.10.2;2.7.11.13;3.6.1.-;1.1.1.205;3.1.6.8;3.1.6.12;3.2.1.-;3.2.1.22;2.7.11.24;3.1.27.-;3.4.14.1;3.6.4.6;3.5.3.15;3.4.21.37;3.1.6.4;3.4.21.76;3.5.3.1;1.6.5.5;3.5.1.26;3.1.6.14;3.1.3.16;5.3.99.3;6.3.4.21;2.4.1.1;2.3.3.8;1.8.4.-;5.3.4.1;3.2.1.51;1.6.2.2;3.4.14.2;3.4.21.4;3.4.19.9", "go_molecular_function": "GO:0003723 RNA binding;GO:0016787 hydrolase activity;GO:0004540 RNA nuclease activity;GO:0004521 RNA endonuclease activity;GO:0033897 ribonuclease T2 activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005758 mitochondrial intermembrane space;GO:0005788 endoplasmic reticulum lumen;GO:0005764 lysosome", "go_biological_process": "GO:0045087 innate immune response;GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "C0HKG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UFY4-1", "uniprot_id": "RSH3A_MOUSE", "mass": 58786.0, "length": 516, "protein_name": "Radial spoke head protein 3 homolog A", "gene_name": "Rsph3a", "organism": "Mouse", "refseq_name": "radial spoke head protein 3 homolog A", "refseq_ac": "NP_080065", "gene_names_uniprotkb": "Rsph3a; Rshl2a; Rshl2", "gene_names_refseq": "1700012G05Rik; 4930524H12Rik; Rshl2a; Rshl2; Rsph3a", "protein_names_uniprotkb": "Radial spoke head protein 3 homolog A; A-kinase anchor protein RSPH3A; Radial spoke head-like protein 2A", "protein_names_refseq": "A-kinase anchor protein RSPH3A; radial spoke head protein 3 homolog A; radial spoke head-like protein 2A; radial spokehead-like 2A; radial spokehead-like 2", "tax_id": 10090, "disease": "primary ciliary dyskinesia 32 (Disease Ontology:DOID:0110603)", "pathway": " (mmu:66832)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17971504;21750661;25079589;26082196", "class_list": "", "function": "May function as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (By similarity). Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results suggest that RSP3 is a nucleocytoplasmic shuttling protein and plays an essential role in neurogenesis., [RefSeq, PubMed]; Rshl2 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; The subcellular localization and function of mammalian RSP3 in mammalian cells and developing CNS., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8J2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0097729 9+2 motile cilium;GO:0001535 radial spoke head", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0003341 cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3UFY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62241-1", "uniprot_id": "RU1C_MOUSE", "mass": 17364.0, "length": 159, "protein_name": "U1 small nuclear ribonucleoprotein C", "gene_name": "Snrpc", "organism": "Mouse", "refseq_name": "U1 small nuclear ribonucleoprotein C isoform 1", "refseq_ac": "NP_035562", "gene_names_uniprotkb": "Snrpc; SNRPC; Snrp1c", "gene_names_refseq": "Snrp1c; Snrpc; U1-C; U1C", "protein_names_uniprotkb": "U1 small nuclear ribonucleoprotein C; U1 snRNP C; U1-C; U1C", "protein_names_refseq": "U1 small nuclear ribonucleoprotein 1C; U1 small nuclear ribonucleoprotein C isoform 1; U1 snRNP C; U1 snRNP protein C", "tax_id": 10090, "disease": "mixed connective tissue disease (Disease Ontology:DOID:3492); connective tissue disease (Disease Ontology:DOID:65); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:20630); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;25625564;9031639;9094092", "class_list": "", "function": "Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]; These studies establish potentially converging disease mechanisms in amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy, with ALS-causative mutants acquiring properties representing both gain and loss of function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030627 pre-mRNA 5'-splice site binding;GO:1990446 U1 snRNP binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0015030 Cajal body;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62241-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQ33-1", "uniprot_id": "RGMB_MOUSE", "mass": 47181.0, "length": 436, "protein_name": "Repulsive guidance molecule B", "gene_name": "Rgmb", "organism": "Mouse", "refseq_name": "repulsive guidance molecule B isoform 2 precursor", "refseq_ac": "NP_848730", "gene_names_uniprotkb": "Rgmb", "gene_names_refseq": "1110059F19Rik; DRAGON; Rgmb", "protein_names_uniprotkb": "Repulsive guidance molecule B; DRAGON; DRG11-responsive axonal guidance and outgrowth of neurite", "protein_names_refseq": "DRG11-responsive axonal guidance and outgrowth of neurite; RGM domain family, member B; repulsive guidance molecule B isoform 2 precursor; repulsive guidance molecule B", "tax_id": 10090, "disease": "", "pathway": " (mmu:68799)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14678836;14749425;14985445;15053976;15671031;15890774;21750661;35820727;38042034", "class_list": "", "function": "A gene with promoter binding to the DNA binding domain of DRG11; encodes a conserved developmentally regulated membrane-associated glycosyl-phosphatidylinositol-anchored protein which promotes dorsal root ganglion neuron adhesion., [RefSeq, PubMed]; Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system. Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling. Promotes neuronal adhesion. May inhibit neurite outgrowth (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Predominantly expressed in developing neuron., [RefSeq, PubMed]; Regulatory role of RGMb in lung injury promoted by the combination of carbon ion irradiation and anti-PD-1 antibody through Erk1/2 and p38 MAPK pathways., [RefSeq, PubMed]; The direct interaction of DRAGON with bone morphogenetic protein (BMP) ligands and receptors indicates that it is a BMP co-receptor that potentiates BMP signaling., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q501K0;Q8BNR6;Q8CBM7", "ec_number_list": "", "go_molecular_function": "GO:0015026 coreceptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment;GO:0098552 side of membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0045893 positive regulation of DNA-templated transcription;GO:0030509 BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7TQ33-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CB87-1", "uniprot_id": "RAB44_MOUSE", "mass": 106328.0, "length": 973, "protein_name": "Ras-related protein Rab-44", "gene_name": "Rab44", "organism": "Mouse", "refseq_name": "ras-related protein Rab-44", "refseq_ac": "NP_001351777", "gene_names_uniprotkb": "Rab44", "gene_names_refseq": "9830134C10Rik; Rab44", "protein_names_uniprotkb": "Ras-related protein Rab-44; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-44", "tax_id": 10090, "disease": "", "pathway": " (mmu:442827); (R-MMU-6798695); (R-MMU-8873719)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "21750661;28791425;32238914;33641252;35469841;35743062;36126775;36210013;36674510", "class_list": "", "function": "Data show that Rab GTPase Rab44 affects nuclear factor of activated T-cells c1 (NFATc1) signaling in RANKL-stimulated macrophages., [RefSeq, PubMed]; In bone marrow macrophages, GTP-bound RAB44 negatively regulates osteoclastogenesis by controlling lysosomal Ca(2+) influx and affecting NFATC1 signaling (PubMed:28791425, PubMed:35743062). Interaction of GDP-bound RAB44 with coronin-1C/COROC1C in macrophage promotes membrane fusion and osteoclast generation (PubMed:35743062)., [UniProtKB, PubMed, PubMed]; Large Rab GTPase Rab44 regulates microtubule-dependent retrograde melanosome transport in melanocytes., [RefSeq, PubMed]; Rab44 Deficiency Induces Impaired Immune Responses to Nickel Allergy. Publication Status: Online-Only, [RefSeq, PubMed]; Rab44 isoforms similarly promote lysosomal exocytosis, but exhibit differential localization in mast cells., [RefSeq, PubMed]; Rab44 regulates murine mast cell-driven anaphylaxis through kinesin-1-dependent secretory granule translocation., [RefSeq, PubMed]; The large GTPase Rab44 regulates granule exocytosis in mast cells and IgE-mediated anaphylaxis., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Promotes mast cell degranulation upon IgE Fc receptor (FcERI)-mediated activation (PubMed:33641252)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A2Y9CZI3;B9EID0", "ec_number_list": "3.6.5.-;2.3.2.27;7.6.2.1;3.1.3.48;3.6.5.2;3.6.5.3;1.14.19.17;5.2.1.-;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.4.24.81;3.6.1.5;2.7.11.1;1.14.14.18;3.4.21.73;3.6.5.4;2.4.1.-;2.4.1.275;2.4.1.22;2.4.1.38;2.4.1.90;3.6.5.5;3.4.23.-;2.5.1.60;1.1.1.-;3.2.1.20;3.6.1.-;3.4.24.-;3.6.1.15;2.3.1.51;2.3.1.23;2.3.1.67;2.3.1.25;2.3.1.78;7.6.2.-;1.6.3.-;3.2.2.6;3.4.16.2;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;3.6.-.-;3.1.3.5;3.1.3.2;3.2.1.25;2.5.1.18;3.5.1.92;3.1.4.4;2.3.1.20;2.3.1.76", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0045671 negative regulation of osteoclast differentiation;GO:0045672 positive regulation of osteoclast differentiation;GO:0002553 histamine secretion by mast cell;GO:0043303 mast cell degranulation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CB87-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62849-1", "uniprot_id": "RS24_MOUSE", "mass": 15423.0, "length": 133, "protein_name": "Small ribosomal subunit protein eS24", "gene_name": "Rps24", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein eS24 isoform 1", "refseq_ac": "NP_035427", "gene_names_uniprotkb": "Rps24", "gene_names_refseq": "Rps24", "protein_names_uniprotkb": "Small ribosomal subunit protein eS24; 40S ribosomal protein S24", "protein_names_refseq": "40S ribosomal protein S24; MRP S24; small ribosomal subunit protein eS24 isoform 1; small ribosomal subunit protein eS24", "tax_id": 10090, "disease": "Diamond-blackfan anemia 3 (Disease Ontology:DOID:0111887); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:20088); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 13, "publication_id_list": "1840675;21750661;22645316;33300544;33725478;34428180;35820727;36517592;37453647;37507081;37828378;39627609;8127713", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Required for processing of pre-rRNA and maturation of 40S ribosomal subunits (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P16632;Q642L0;Q6PDB5", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:0006412 translation;GO:0034101 erythrocyte homeostasis;GO:0006364 rRNA processing;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P62849-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHQ4-1", "uniprot_id": "RB40C_MOUSE", "mass": 31348.0, "length": 281, "protein_name": "Ras-related protein Rab-40C", "gene_name": "Rab40c", "organism": "Mouse", "refseq_name": "ras-related protein Rab-40C", "refseq_ac": "NP_631893", "gene_names_uniprotkb": "Rab40c", "gene_names_refseq": "RAR3; Rab40c", "protein_names_uniprotkb": "Ras-related protein Rab-40C; 3.6.5.2; SOCS box-containing protein RAR3", "protein_names_refseq": "RAR (RAS like GTPASE) like; SOCS box containing protein RAR3; ras-related protein Rab-40C", "tax_id": 10090, "disease": "", "pathway": " (mmu:224624); (R-MMU-8873719)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;23638186;30016717", "class_list": "", "function": "RAB40C small GTPase acts as substrate-recognition component of the ECS(RAB40C) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration. Also negatively regulate lipid droplets accumulation in a GTP-dependent manner., [UniProtKB, UniProtKB]; Stimulation for adipocyte differentiation increases the expression of Rab40c in 3T3-L1 cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;2.5.1.60;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0016477 cell migration;GO:0035556 intracellular signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051894 positive regulation of focal adhesion assembly;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VHQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBS9-1", "uniprot_id": "OSBL3_MOUSE", "mass": 96966.0, "length": 855, "protein_name": "Oxysterol-binding protein-related protein 3", "gene_name": "Osbpl3", "organism": "Mouse", "refseq_name": "oxysterol-binding protein-related protein 3 isoform 2", "refseq_ac": "NP_001157117", "gene_names_uniprotkb": "Osbpl3; Orp3", "gene_names_refseq": "1200014M06Rik; 6720421I08Rik; A530055M08; ORP-3; ORP3; OSBP3; Osbpl3", "protein_names_uniprotkb": "Oxysterol-binding protein-related protein 3; ORP-3; OSBP-related protein 3; Phosphoinositide transfer protein", "protein_names_refseq": "OSBP-related protein 3; oxysterol-binding protein-related protein 3 isoform 2; oxysterol-binding protein-related protein 3; phosphoinositide transfer protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:71720); (R-MMU-192105)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;14593528;19144319;21183079;21750661;30028970;31219806;36781118;37740130", "class_list": "", "function": "Lipid transfer protein that mediates the non-vesicular transport of phosphoinositide 4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), or PI(4)P) at the plasma membrane (PM)/ endoplasmic reticulum (ER) contact sites. Extracts PI4P from the PM, in exchange for phosphatidylcholine. Can bind to the ER membrane protein VAPA and recruit VAPA to PM sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics. Publication Status: Online-Only, [RefSeq, PubMed]; Oxysterol-binding protein-like 3 is a novel target gene of peroxisome proliferator-activated receptor gamma in fatty liver disease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QNI5", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0120015 sterol transfer activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0097038 perinuclear endoplasmic reticulum", "go_biological_process": "GO:0006699 bile acid biosynthetic process;GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9DBS9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CSU0-1", "uniprot_id": "RPR1B_MOUSE", "mass": 36884.0, "length": 326, "protein_name": "Regulation of nuclear pre-mRNA domain-containing protein 1B", "gene_name": "Rprd1b", "organism": "Mouse", "refseq_name": "regulation of nuclear pre-mRNA domain-containing protein 1B isoform a", "refseq_ac": "NP_001278063", "gene_names_uniprotkb": "Rprd1b; Crept", "gene_names_refseq": "2610304G08Rik; 2810446G03Rik; Crept; Rprd1b", "protein_names_uniprotkb": "Regulation of nuclear pre-mRNA domain-containing protein 1B; Cell cycle-related and expression-elevated protein in tumor", "protein_names_refseq": "cell cycle-related and expression-elevated protein in tumor; regulation of nuclear pre-mRNA domain-containing protein 1B isoform a; regulation of nuclear pre-mRNA domain-containing protein 1B", "tax_id": 10090, "disease": "", "pathway": " (mmu:70470); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15345747;19144319;21183079;21750661;22264791;24982424;28893536;31054975", "class_list": "", "function": "Crosstalk between RNA Pol II C-terminal domain acetylation and phosphorylation via RPRD1B protein and its isoforms has been reported., [RefSeq, PubMed]; Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mechanistically, CREPT regulated beta-catenin/TCF4/cyclin D1 pathway in BC. In conclusion, the data suggested that miR-138/CREPT involved BC progression, providing potential therapeutic targets for BC., [RefSeq, PubMed]; Study suggests that CREPT acts as an activator to promote transcriptional activity of the beta-catenin.TCF4 complex in response to Wnt signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ACF2;A2ACF4;A2ACF5;A2ACF6;Q1WDE6;Q3U8H1;Q3UGH1;Q3USX3;Q6GTJ6", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0000993 RNA polymerase II complex binding;GO:0099122 RNA polymerase II C-terminal domain binding;GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0010564 regulation of cell cycle process;GO:0001111 RNA polymerase II promoter clearance;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CSU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D478-1", "uniprot_id": "ODF2L_MOUSE", "mass": 74151.0, "length": 642, "protein_name": "Protein BCAP", "gene_name": "Odf2l", "organism": "Mouse", "refseq_name": "protein BCAP isoform 1", "refseq_ac": "NP_001156010", "gene_names_uniprotkb": "Odf2l; Bcap; D3Ertd250e", "gene_names_refseq": "4733401D09Rik; 9630045K08Rik; D3Ertd250e; Odf2l", "protein_names_uniprotkb": "Protein BCAP; Basal body centriole-associated protein; Outer dense fiber protein 2-like", "protein_names_refseq": "basal body centriole-associated protein; outer dense fiber protein 2-like; protein BCAP isoform 1; protein BCAP", "tax_id": 10090, "disease": "", "pathway": " (mmu:52184)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;28775150", "class_list": "", "function": "Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CD32;Q8VDY5;Q9D647", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005814 centriole;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body;GO:0005929 cilium", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D478-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUJ8-1", "uniprot_id": "ORC6_MOUSE", "mass": 29188.0, "length": 262, "protein_name": "Origin recognition complex subunit 6", "gene_name": "Orc6", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Orc6; Orc6l", "gene_names_refseq": "", "protein_names_uniprotkb": "Origin recognition complex subunit 6", "protein_names_refseq": "", "tax_id": 10090, "disease": "Meier-Gorlin syndrome 3 (Disease Ontology:DOID:0080514)", "pathway": " (R-MMU-176187); (R-MMU-68616); (R-MMU-68689); (R-MMU-68949); (R-MMU-68962)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "12614612;21750661;34428180", "class_list": "", "function": "Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0005664 nuclear origin of replication recognition complex;GO:0000808 origin recognition complex", "go_biological_process": "GO:0006270 DNA replication initiation;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9WUJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91W34-1", "uniprot_id": "RUSF1_MOUSE", "mass": 50469.0, "length": 466, "protein_name": "RUS family member 1", "gene_name": "Rusf1", "organism": "Mouse", "refseq_name": "RUS family member 1 isoform 1", "refseq_ac": "NP_663565", "gene_names_uniprotkb": "Rusf1", "gene_names_refseq": "Rusf1", "protein_names_uniprotkb": "RUS family member 1", "protein_names_refseq": "RUS family member 1 isoform 1; RUS1 family protein C16orf58 homolog; UPF0420 protein C16orf58 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:233913)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCP4;Q3UEA8;Q3UFY1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91W34-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCR9-1", "uniprot_id": "OCEL1_MOUSE", "mass": 25111.0, "length": 219, "protein_name": "Occludin/ELL domain-containing protein 1", "gene_name": "Ocel1", "organism": "Mouse", "refseq_name": "occludin/ELL domain-containing protein 1 isoform 1", "refseq_ac": "NP_084141", "gene_names_uniprotkb": "Ocel1", "gene_names_refseq": "9430098E02Rik; Ocel1", "protein_names_uniprotkb": "Occludin/ELL domain-containing protein 1", "protein_names_refseq": "occludin/ELL domain-containing protein 1 isoform 1; occludin/ELL domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:77090)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2L0;Q9CX17", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005923 bicellular tight junction;GO:0016324 apical plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0070830 bicellular tight junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VCR9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K305-1", "uniprot_id": "NSL1_MOUSE", "mass": 31739.0, "length": 281, "protein_name": "Kinetochore-associated protein NSL1 homolog", "gene_name": "Nsl1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nsl1", "gene_names_refseq": "", "protein_names_uniprotkb": "Kinetochore-associated protein NSL1 homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:381318); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0000776 kinetochore;GO:0000940 outer kinetochore", "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0000070 mitotic sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K305-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62176-1", "uniprot_id": "RBM38_MOUSE", "mass": 25364.0, "length": 237, "protein_name": "RNA-binding protein 38", "gene_name": "Rbm38", "organism": "Mouse", "refseq_name": "RNA-binding protein 38 isoform a", "refseq_ac": "NP_062420", "gene_names_uniprotkb": "Rbm38; Rnpc1; Seb4l; Seb4", "gene_names_refseq": "Rbm38; Rnpc1; Seb4l; Seb4", "protein_names_uniprotkb": "RNA-binding protein 38; RNA-binding motif protein 38; RNA-binding region-containing protein 1; ssDNA-binding protein SEB4", "protein_names_refseq": "RNA-binding protein 38 isoform a; RNA-binding protein 38; RNA-binding region (RNP1, RRM) containing 1; RNA-binding region-containing protein 1; seb4 mRNA; ssDNA-binding protein SEB4", "tax_id": 10090, "disease": "", "pathway": " (mmu:56190)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16393994;16479539;19817877;21750661;22872234;25428506;30084848;31219806;34428180;36210013;37158107", "class_list": "", "function": "Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis., [RefSeq, PubMed]; RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2 (By similarity). Plays a role in myogenic differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U418;Q922Z2", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0010830 regulation of myotube differentiation;GO:0006397 mRNA processing;GO:0008285 negative regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q62176-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D3W1-1", "uniprot_id": "RSP14_MOUSE", "mass": 37809.0, "length": 341, "protein_name": "Radial spoke head 14 homolog", "gene_name": "Rsph14", "organism": "Mouse", "refseq_name": "radial spoke head 14 homolog isoform 1", "refseq_ac": "NP_001157005", "gene_names_uniprotkb": "Rsph14; Rtdr1", "gene_names_refseq": "4933431K05Rik; Rsph14; Rtdr1", "protein_names_uniprotkb": "Radial spoke head 14 homolog; Rhabdoid tumor deletion region protein 1", "protein_names_refseq": "radial spoke head 14 homolog isoform 1; radial spoke head 14 homolog; rhabdoid tumor deletion region gene 1; rhabdoid tumor deletion region protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71236)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;36417862", "class_list": "", "function": "Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0001534 radial spoke;GO:0005576 extracellular region;GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0097729 9+2 motile cilium", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:0003341 cilium movement;GO:0007618 mating", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D3W1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIT9-1", "uniprot_id": "SBSN_MOUSE", "mass": 72334.0, "length": 700, "protein_name": "Suprabasin", "gene_name": "Sbsn", "organism": "Mouse", "refseq_name": "suprabasin isoform 2 precursor", "refseq_ac": "NP_001077372", "gene_names_uniprotkb": "Sbsn", "gene_names_refseq": "1110005D19Rik; Sbsn", "protein_names_uniprotkb": "Suprabasin", "protein_names_refseq": "suprabasal-specific protein; suprabasin isoform 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:282619)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12228223;15256262;17330888;21750661;25283635;30919591;31219806;34428180;35484216", "class_list": "", "function": "Findings suggest that SBSN is involved in the angiogenic potential of tumor endothelial cells (TEC) and may be a novel TEC marker., [RefSeq, PubMed]; SBSN drives bladder cancer metastasis via EGFR/SRC/STAT3 signalling., [RefSeq, PubMed]; SBSN expression was observed in human clinical specimens of colon and ovarian carcinomas, as well as in circulating tumour cells and metastases of the 4T1 mouse model. The association of SBSN expression with progressive stages of cancer development indicates its role in cancer evolution and therapy resistance., [RefSeq, PubMed]; Sbsn, Dmkn and Krtdap are coordinately expressed during epidermal morphogenesis., [RefSeq, PubMed]; These results indicate that the suprabasin protein potentially plays a role in the process of epidermal differentiation. GeneRIF: These results indicate that the suprabasin protein potentially plays a role in the process of epidermal differentiation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6SZK0;Q80WB4;Q8K2V9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CIT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K561-1", "uniprot_id": "OTOAN_MOUSE", "mass": 126430.0, "length": 1137, "protein_name": "Otoancorin", "gene_name": "Otoa", "organism": "Mouse", "refseq_name": "otoancorin precursor", "refseq_ac": "NP_647471", "gene_names_uniprotkb": "Otoa", "gene_names_refseq": "Otoa", "protein_names_uniprotkb": "Otoancorin", "protein_names_refseq": "otoancorin precursor", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 22 (Disease Ontology:DOID:0110480)", "pathway": " (mmu:246190); (R-MMU-163125)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;11972037;21750661;25428506", "class_list": "", "function": "May act as an adhesion molecule., [UniProtKB, PubMed]; Otoancorin is defective in autosomal recessive deafness DFNB22, [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0009986 cell surface;GO:0016324 apical plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:0035264 multicellular organism growth;GO:0007605 sensory perception of sound;GO:0019226 transmission of nerve impulse", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K561-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97461-1", "uniprot_id": "RS5_MOUSE", "mass": 22876.0, "length": 204, "protein_name": "Small ribosomal subunit protein uS7", "gene_name": "Rps5", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS7", "refseq_ac": "NP_033121", "gene_names_uniprotkb": "Rps5", "gene_names_refseq": "Rps5", "protein_names_uniprotkb": "Small ribosomal subunit protein uS7; 40S ribosomal protein S5", "protein_names_refseq": "40S ribosomal protein S5; S5 ribosomal protein; small ribosomal subunit protein uS7", "tax_id": 10090, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (mmu:20103); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 8, "publication_id_list": "21750661;22645316;23806337;31599954;36517592;37453647;38888351;9202169", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, PubMed]; Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB]; Exosomes from adipose-derived stem cells regulate macrophage polarization and accelerate diabetic wound healing via the circ-Rps5/miR-124-3p axis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08607;Q91V55", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:0006412 translation;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis;GO:0006450 regulation of translational fidelity;GO:0140236 translation at presynapse", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P97461-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60898-1", "uniprot_id": "RPB9_MOUSE", "mass": 14523.0, "length": 125, "protein_name": "DNA-directed RNA polymerase II subunit RPB9", "gene_name": "Polr2i", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase II subunit RPB9", "refseq_ac": "NP_081535", "gene_names_uniprotkb": "Polr2i", "gene_names_refseq": "2810002B19Rik; Polr2i", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit RPB9; DNA-directed RNA polymerase II subunit I; RNA polymerase II 14.5 kDa subunit; RNA polymerase II subunit B9; RPB14.5", "protein_names_refseq": "DNA-directed RNA polymerase II subunit I; DNA-directed RNA polymerase II subunit RPB9; RNA polymerase II 14.5 kDa subunit; RNA polymerase II subunit B9; RPB14.5", "tax_id": 10090, "disease": "", "pathway": " (mmu:69920); (R-MMU-112382); (R-MMU-113418); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-6803529); (R-MMU-6807505); (R-MMU-72086); (R-MMU-72163); (R-MMU-72165); (R-MMU-72203); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-77075); (R-MMU-9018519); (R-MMU-9770562)", "pathway_count": 22, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005665 RNA polymerase II, core complex;GO:0000428 DNA-directed RNA polymerase complex", "go_biological_process": "GO:0001193 maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0006283 transcription-coupled nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P60898-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q78YZ6-1", "uniprot_id": "SCOC_MOUSE", "mass": 14155.0, "length": 125, "protein_name": "Short coiled-coil protein", "gene_name": "Scoc", "organism": "Mouse", "refseq_name": "short coiled-coil protein isoform a", "refseq_ac": "NP_001034226", "gene_names_uniprotkb": "Scoc; Scoco", "gene_names_refseq": "0610011C06Rik; 2810002J11Rik; SCOCO; Scoc", "protein_names_uniprotkb": "Short coiled-coil protein", "protein_names_refseq": "short coiled-coil protein isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:56367); (R-MMU-6811440)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Positive regulator of amino acid starvation-induced autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RV68;Q32NY7;Q3TJC8;Q58E48;Q5U450;Q9WU55", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0016239 positive regulation of macroautophagy;GO:0061635 regulation of protein complex stability", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q78YZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UZY0-1", "uniprot_id": "SFI1_MOUSE", "mass": 144033.0, "length": 1216, "protein_name": "Protein SFI1 homolog", "gene_name": "Sfi1", "organism": "Mouse", "refseq_name": "protein SFI1 homolog isoform 1", "refseq_ac": "NP_084483", "gene_names_uniprotkb": "Sfi1; Kiaa0542", "gene_names_refseq": "Sfi1", "protein_names_uniprotkb": "Protein SFI1 homolog", "protein_names_refseq": "protein SFI1 homolog isoform 1; protein SFI1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:78887); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 4, "publication_id_list": "21750661;26149421;31219806;31599954", "class_list": "", "function": "Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2., [UniProtKB, UniProtKB]; Study showed major differences in gene copy number in natural populations. CWC22, SFI1, and HJURP are highly conserved genes with the most copy-number variation. They all exhibit population-specific expansion patterns, perhaps for local adaptations., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3KQN2;Q5NC00;Q6ZQ99;Q80ZJ4;Q80ZY0;Q8R0V8;Q9CTY8", "ec_number_list": "", "go_molecular_function": "GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005814 centriole", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3UZY0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3UYX5-1", "uniprot_id": "RGS22_MOUSE", "mass": 145883.0, "length": 1258, "protein_name": "Regulator of G protein signaling 22", "gene_name": "Rgs22", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 22", "refseq_ac": "NP_001182677", "gene_names_uniprotkb": "Rgs22", "gene_names_refseq": "Rgs22", "protein_names_uniprotkb": "Regulator of G protein signaling 22", "protein_names_refseq": "regulator of G-protein signaling 22", "tax_id": 10090, "disease": "", "pathway": " (mmu:626596)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18703424;21750661;31219806;34428180;39927985", "class_list": "", "function": "Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0001650 fibrillar center", "go_biological_process": "GO:0009968 negative regulation of signal transduction;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "G3UYX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K202-1", "uniprot_id": "RPA49_MOUSE", "mass": 54034.0, "length": 482, "protein_name": "DNA-directed RNA polymerase I subunit RPA49", "gene_name": "Polr1e", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase I subunit RPA49 isoform a", "refseq_ac": "NP_001272729", "gene_names_uniprotkb": "Polr1e; Paf53; Praf1", "gene_names_refseq": "53kDa; D030019D19Rik; Paf53; Polr1e; Praf1", "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit RPA49; DNA-directed RNA polymerase I subunit E; RNA polymerase I subunit A49; RNA polymerase I-associated factor 1; RNA polymerase I-associated factor 53", "protein_names_refseq": "DNA-directed RNA polymerase I subunit E; DNA-directed RNA polymerase I subunit RPA49 isoform a; DNA-directed RNA polymerase I subunit RPA49; RNA polymerase I associated factor (Paf53); RNA polymerase I subunit A49; RNA polymerase I-associated factor 53; polymerase (RNA) I associated factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:64424); (R-MMU-5250924); (R-MMU-73762); (R-MMU-73772); (R-MMU-73863)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "15226435;21750661;22849406;28042089;31219806;37356716;8641287;9254723", "class_list": "", "function": "Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates (PubMed:8641287, PubMed:9254723). Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (PubMed:8641287)., [UniProtKB, PubMed, PubMed]; DNA sequencing demonstrated that in the absence of ectopic PAF53 expression, cells demonstrated unique means of surviving; including recombination or the utilization of alternative reading frames. We never observed a clone in which one PAF53 gene is expressed, unless there was also ectopic expression In the absence of ectopic gene expression, the gene products of both endogenous genes were expressed, irrespective of wheth, [RefSeq, PubMed]; PAF49: An RNA Polymerase I subunit essential for rDNA transcription and stabilization of PAF53., [RefSeq, PubMed]; Yeast A34.5/A49 and mammalian PAF49/PAF53 heterodimeric complexes interact through species-specific sequence elements that appear to assume similar structural motifs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AXQ6;B1AXQ7;Q62034;Q8BQG9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0001179 RNA polymerase I general transcription initiation factor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center;GO:0005736 RNA polymerase I complex;GO:0000428 DNA-directed RNA polymerase complex", "go_biological_process": "GO:0006362 transcription elongation by RNA polymerase I;GO:0006361 transcription initiation at RNA polymerase I promoter;GO:0042790 nucleolar large rRNA transcription by RNA polymerase I;GO:0001188 RNA polymerase I preinitiation complex assembly;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K202-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97797-1", "uniprot_id": "SHPS1_MOUSE", "mass": 56414.0, "length": 513, "protein_name": "Tyrosine-protein phosphatase non-receptor type substrate 1", "gene_name": "Sirpa", "organism": "Mouse", "refseq_name": "tyrosine-protein phosphatase non-receptor type substrate 1 isoform 4 precursor", "refseq_ac": "NP_001277950", "gene_names_uniprotkb": "Sirpa; Bit; Myd1; Ptpns1; Shps1; Sirp", "gene_names_refseq": "Bit; CD172a; Idd13.2; P84; Ptpns1; SHP-1; SHPS-1; SIRP; Sirpa", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type substrate 1; Bit; Brain Ig-like molecule with tyrosine-based activation motifs; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; MyD-1 antigen; SHP substrate 1; SHPS-1; Signal-regulatory protein alpha-1; Sirp-alpha-1; mSIRP-alpha1; p84", "protein_names_refseq": "CD172 antigen-like family member A; SHP substrate 1; brain Ig-like molecule with tyrosine-based activation motifs; brain immunological-like with tyrosine-based motifs; inhibitory receptor SHPS-1; mSIRP-alpha1; myD-1 antigen; protein tyrosine phosphatase, non-receptor type substrate 1; signal-regulatory protein alpha-1; sirp-alpha-1; tyrosine-protein phosphatase non-receptor type substrate 1 isoform 4 precursor; tyrosine-protein phosphatase non-receptor type substrate 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19261); (R-MMU-202733); (R-MMU-2172127); (R-MMU-391160); (R-MMU-6798695)", "pathway_count": 5, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;10585853;10662797;11471062;16944957;18034455;18045614;19144319;21750661;2303162;26192747;26495903;30726215;30899004;33300544;34428180;34678516;38245585;38758648;40885482;9070220;9073522;9348339;9507023;9712903;9872987", "class_list": "", "function": "Immunoglobulin-like cell surface receptor for CD47 (PubMed:18045614). Acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity). Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization (PubMed:30726215). Receptor for THBS1 (By similarity). Interaction with THBS1 stimulates phosphorylation of SIRPA (By similarity). In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; Podocyte SIRPalpha reduction aggravates lupus nephritis via promoting T cell inflammatory responses., [RefSeq, PubMed]; Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPalpha. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 12, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 15, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 15, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 15, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 39, "disease_count": 0, "glyco_site_count": 25, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J1Z7;E0CYM8;E9QPT7;O08907;O35924;O88555;O88556;P97796;Q8R559;Q9QX57;Q9WTN4", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:1990405 protein antigen binding;GO:0019903 protein phosphatase binding;GO:0030695 GTPase regulator activity;GO:0045309 protein phosphorylated amino acid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0032651 regulation of interleukin-1 beta production;GO:0006911 phagocytosis, engulfment;GO:0007015 actin filament organization;GO:0016477 cell migration;GO:0032715 negative regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 8.8, "record_id": "P97797-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99L28-1", "uniprot_id": "RLP24_MOUSE", "mass": 19611.0, "length": 163, "protein_name": "Probable ribosome biogenesis protein RLP24", "gene_name": "Rsl24d1", "organism": "Mouse", "refseq_name": "probable ribosome biogenesis protein RLP24", "refseq_ac": "NP_941011", "gene_names_uniprotkb": "Rsl24d1", "gene_names_refseq": "2410159K22Rik; Rsl24d1", "protein_names_uniprotkb": "Probable ribosome biogenesis protein RLP24; Ribosomal L24 domain-containing protein 1; Ribosomal protein L24-like", "protein_names_refseq": "60S ribosomal protein L30 isolog; probable ribosome biogenesis protein RLP24; ribosomal L24 domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:225215)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;36690642", "class_list": "", "function": "Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RSL24D1 sustains steady-state ribosome biogenesis and pluripotency translational programs in embryonic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005634 nucleus", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99L28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q1RNF8-1", "uniprot_id": "SAM11_MOUSE", "mass": 57784.0, "length": 542, "protein_name": "Sterile alpha motif domain-containing protein 11", "gene_name": "Samd11", "organism": "Mouse", "refseq_name": "sterile alpha motif domain-containing protein 11 isoform 2", "refseq_ac": "NP_001342638", "gene_names_uniprotkb": "Samd11", "gene_names_refseq": "Samd11; mr-s", "protein_names_uniprotkb": "Sterile alpha motif domain-containing protein 11; Major retinal SAM domain-containing protein; Mr-s; SAM domain-containing protein 11", "protein_names_refseq": "SAM domain-containing protein 11; major retinal SAM domain-containing protein; sterile alpha motif domain-containing protein 11 isoform 2; sterile alpha motif domain-containing protein 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:231004)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16539743;21750661;33603070", "class_list": "", "function": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, essential for establishing rod photoreceptor cell identity and function by silencing nonrod gene expression in developing rod photoreceptor cells., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TU11", "ec_number_list": "", "go_molecular_function": "GO:0032093 SAM domain binding;GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035102 PRC1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0046548 retinal rod cell development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q1RNF8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NXM2-1", "uniprot_id": "RCBT1_MOUSE", "mass": 58379.0, "length": 531, "protein_name": "RCC1 and BTB domain-containing protein 1", "gene_name": "Rcbtb1", "organism": "Mouse", "refseq_name": "RCC1 and BTB domain-containing protein 1 isoform 1", "refseq_ac": "NP_082040", "gene_names_uniprotkb": "Rcbtb1", "gene_names_refseq": "5430409I18Rik; CLLD7; CLLL7; Rcbtb1", "protein_names_uniprotkb": "RCC1 and BTB domain-containing protein 1; Regulator of chromosome condensation and BTB domain-containing protein 1", "protein_names_refseq": "RCC1 and BTB domain-containing protein 1 isoform 1; RCC1 and BTB domain-containing protein 1; regulator of chromosome condensation and BTB domain-containing protein 1", "tax_id": 10090, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); allergic disease (Disease Ontology:DOID:1205)", "pathway": " (mmu:71330)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;27486781", "class_list": "", "function": "May be involved in cell cycle regulation by chromatin remodeling., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTZ6;Q8BZV0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6NXM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BXR9-1", "uniprot_id": "OSBL6_MOUSE", "mass": 108920.0, "length": 959, "protein_name": "Oxysterol-binding protein-related protein 6", "gene_name": "Osbpl6", "organism": "Mouse", "refseq_name": "oxysterol-binding protein-related protein 6 isoform b", "refseq_ac": "NP_001277662", "gene_names_uniprotkb": "Osbpl6", "gene_names_refseq": "1110062M20Rik; ORP-6; Osbpl6; mKIAA4128", "protein_names_uniprotkb": "Oxysterol-binding protein-related protein 6; ORP-6; OSBP-related protein 6", "protein_names_refseq": "OSBP-related protein 6; oxysterol-binding protein-related protein 6 isoform b; oxysterol-binding protein-related protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:99031); (R-MMU-192105)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;14593528;21750661;22517741;22645316;26941018;30028970;32848054;35518199;40021952;40885482", "class_list": "", "function": "Oxysterol-binding protein-like 6 is a novel regulator of cholesterol trafficking that is part of the miR-33 and miR-27b target gene networks contributing to the maintenance of cholesterol homeostasis., [RefSeq, PubMed]; Regulates cellular transport and efflux of cholesterol. Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (PubMed:30028970, PubMed:35518199). Localizes at the neurons plasma membrane-endoplasmic reticulum contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) from the endoplasmic reticulum for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) from the plasma membrane (PubMed:35518199). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (PubMed:30028970). Weakly binds 25-hydroxycholesterol (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8BYW2", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0120015 sterol transfer activity;GO:0160270 phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0097038 perinuclear endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006699 bile acid biosynthetic process;GO:0032374 regulation of cholesterol transport;GO:0120010 intermembrane phospholipid transfer;GO:0120009 intermembrane lipid transfer", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8BXR9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTU7-1", "uniprot_id": "RCCD1_MOUSE", "mass": 40591.0, "length": 377, "protein_name": "RCC1 domain-containing protein 1", "gene_name": "Rccd1", "organism": "Mouse", "refseq_name": "RCC1 domain-containing protein 1", "refseq_ac": "NP_775621", "gene_names_uniprotkb": "Rccd1", "gene_names_refseq": "5830436H09; E430018M08Rik; Rccd1", "protein_names_uniprotkb": "RCC1 domain-containing protein 1", "protein_names_refseq": "RCC1 domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:269955); (R-MMU-9629569)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;25428506;31219806", "class_list": "", "function": "Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6IS64;Q8BJF2;Q8C0K3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005694 chromosome", "go_biological_process": "GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BTU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0L3-1", "uniprot_id": "OC90_MOUSE", "mass": 52445.0, "length": 485, "protein_name": "Otoconin-90", "gene_name": "Oc90", "organism": "Mouse", "refseq_name": "otoconin-90 isoform 1 precursor", "refseq_ac": "NP_035083", "gene_names_uniprotkb": "Oc90; Onc-95; Pla2ll", "gene_names_refseq": "Oc90; Ocn-95; PLA2L; Pla2ll; oc95", "protein_names_uniprotkb": "Otoconin-90; Oc90; Oc95; Otoconin-95", "protein_names_refseq": "otoconin-90 isoform 1 precursor; otoconin-95; phospholipase A2-like like", "tax_id": 10090, "disease": "", "pathway": " (mmu:18256)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17300776;20856818;21655225;21750661;24748133;33554930;35820727;9860971;9892667", "class_list": "", "function": "Functional cooperation between two otoconial proteins Oc90 and Nox3., [RefSeq, PubMed]; Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear (PubMed:17300776). Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure (PubMed:21655225, PubMed:24748133). Together with OTOL1, modulates calcite crystal morphology and growth kinetics (PubMed:24748133). It is unlikely that this protein has phospholipase A2 activity (PubMed:17300776)., [UniProtKB, PubMed, PubMed, PubMed]; Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OTOL1, modulates calcite crystal morphology and growth kinetics. It is unlikely that this protein has phospholipase A2 activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZ60;Q9Z225", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0005198 structural molecule activity;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0050482 arachidonate secretion;GO:0046470 phosphatidylcholine metabolic process;GO:0046471 phosphatidylglycerol metabolic process;GO:0045299 otolith mineralization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z0L3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR83-1", "uniprot_id": "RBM18_MOUSE", "mass": 21649.0, "length": 190, "protein_name": "Probable RNA-binding protein 18", "gene_name": "Rbm18", "organism": "Mouse", "refseq_name": "probable RNA-binding protein 18 isoform 2", "refseq_ac": "NP_001153107", "gene_names_uniprotkb": "Rbm18", "gene_names_refseq": "2010004P11Rik; Rbm18", "protein_names_uniprotkb": "Probable RNA-binding protein 18; RNA-binding motif protein 18", "protein_names_refseq": "probable RNA-binding protein 18 isoform 2; probable RNA-binding protein 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:67889)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CBD4", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0045171 intercellular bridge", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CR83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CEE7-1", "uniprot_id": "RDH13_MOUSE", "mass": 36464.0, "length": 334, "protein_name": "Retinol dehydrogenase 13", "gene_name": "Rdh13", "organism": "Mouse", "refseq_name": "retinol dehydrogenase 13 isoform 2 precursor", "refseq_ac": "NP_001277338", "gene_names_uniprotkb": "Rdh13", "gene_names_refseq": "8430425D21Rik; Rdh13", "protein_names_uniprotkb": "Retinol dehydrogenase 13; 1.1.1.300", "protein_names_refseq": "retinol dehydrogenase 13 isoform 2 precursor", "tax_id": 10090, "disease": "Leber congenital amaurosis (Disease Ontology:DOID:14791)", "pathway": " (mmu:108841); (R-MMU-5365859)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;22605914;29656332;31219806", "class_list": "", "function": "Rdh13 can protect the retina against acute light-induced retinopathy., [RefSeq, PubMed]; Retinol dehydrogenase with a clear preference for NADP. Oxidizes all-trans-retinol, but seems to reduce all-trans-retinal with much higher efficiency. Has no activity towards steroid., [UniProtKB, UniProtKB]; The data suggested that the alleviated liver damage induced by CCl4 in Rdh13(-/-) mice was caused by Cyp2e1 enzymes, which promoted reductive CCl4 metabolism by altering the status of thyroxine metabolism. This result further implicated Rdh13 as a potential drug target in preventing chemically induced liver injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CC07", "ec_number_list": "1.1.1.300;1.1.1.21;1.1.1.372;1.1.1.54;1.1.1.184;1.1.1.-", "go_molecular_function": "GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0042574 retinal metabolic process;GO:0010842 retina layer formation;GO:0042462 eye photoreceptor cell development;GO:0009644 response to high light intensity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CEE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VH51-1", "uniprot_id": "RBM39_MOUSE", "mass": 59407.0, "length": 530, "protein_name": "RNA-binding protein 39", "gene_name": "Rbm39", "organism": "Mouse", "refseq_name": "RNA-binding protein 39 isoform b", "refseq_ac": "NP_001278043", "gene_names_uniprotkb": "Rbm39; Caper; Rnpc2", "gene_names_refseq": "1500012C14Rik; 2310040E03Rik; B330012G18Rik; Rbm39; Rnpc2; caper", "protein_names_uniprotkb": "RNA-binding protein 39; Coactivator of AP-1 and ERs; Coactivator of activating protein 1 and estrogen receptors; RNA-binding motif protein 39; RNA-binding region-containing protein 2", "protein_names_refseq": "Caper alpha; RNA-binding protein 39 isoform b; RNA-binding protein 39; RNA-binding region (RNP1, RRM) containing 2; RNA-binding region-containing protein 2; coactivator of AP-1 and ERs; coactivator of activating protein-1 and estrogen receptors; transcription coactivator CAPER", "tax_id": 10090, "disease": "", "pathway": " (mmu:170791); (R-MMU-2980766); (R-MMU-2995383); (R-MMU-4419969); (R-MMU-72163); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-9013423); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273); (R-MMU-9770562)", "pathway_count": 13, "publication_count": 15, "publication_id_list": "11704680;17242355;18630941;19131326;21183079;21750661;25830341;27324164;27418600;30084848;31219806;34428180;34887587;37507081;39627609", "class_list": "", "function": "CAPER integrates mitochondrial energy metabolism by coactivating ERR-alpha-Gabpa and stress-induced adaptive metabolic responses via NF- kappaB/c-Myc. Erratum:[PLoS Genet. 2015 Jun 15;11(6):e1005316. doi: 10.1371/journal.pgen.1005316. PMID: 26075908] Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing (By similarity). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (PubMed:11704680)., [UniProtKB, UniProtKB, PubMed]; This study shows that negative autoregulation of BMP4 dependent transcription by SIN3B splicing reveals a role for RBM39 Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RJI0;Q99KV0", "ec_number_list": "", "go_molecular_function": "GO:1990446 U1 snRNP binding;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0050733 RS domain binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0015630 microtubule cytoskeleton;GO:0034451 centriolar satellite;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0048024 regulation of mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8VH51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91YE7-1", "uniprot_id": "RBM5_MOUSE", "mass": 92311.0, "length": 815, "protein_name": "RNA-binding protein 5", "gene_name": "Rbm5", "organism": "Mouse", "refseq_name": "RNA-binding protein 5 isoform 1", "refseq_ac": "NP_683732", "gene_names_uniprotkb": "Rbm5; Luca15", "gene_names_refseq": "D030069N10Rik; Rbm5", "protein_names_uniprotkb": "RNA-binding protein 5; Putative tumor suppressor LUCA15; RNA-binding motif protein 5", "protein_names_refseq": "RNA-binding protein 5 isoform 1; RNA-binding protein 5; putative tumor suppressor LUCA15", "tax_id": 10090, "disease": "", "pathway": " (mmu:83486); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "16761314;17363906;19144319;21183079;21750661;30084848;30178827;30779550;31219806;34428180;35820727;37468457;38218585;39627609;40997131", "class_list": "", "function": "Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the spliceosome A complex. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (By similarity). Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Caspase-2 that induces apoptosis (By similarity)., [UniProtKB, UniProtKB]; Gene knockout of RNA binding motif 5 in the brain alters RIMS2 protein homeostasis in the cerebellum and Hippocampus and exacerbates behavioral deficits after a TBI in mice., [RefSeq, PubMed]; RBM5 can inhibit the apoptosis of bone cells by promoting the expression of beta-catenin and can be used as a biomarker for fracture healing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZ19;Q99KV9", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q91YE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7H3-1", "uniprot_id": "RTCA_MOUSE", "mass": 39254.0, "length": 366, "protein_name": "RNA 3'-terminal phosphate cyclase", "gene_name": "RtcA; Rtca", "organism": "Mouse", "refseq_name": "RNA 3'-terminal phosphate cyclase", "refseq_ac": "NP_079793", "gene_names_uniprotkb": "RtcA; Rtca; Rpc1; Rtcd1", "gene_names_refseq": "2310009A18Rik; RPC; Rtca; Rtcd1", "protein_names_uniprotkb": "RNA 3'-terminal phosphate cyclase; 6.5.1.4; RNA cyclase; RNA terminal phosphate cyclase domain-containing protein 1; RNA-3'-phosphate cyclase", "protein_names_refseq": "RNA 3'-terminal phosphate cyclase; RNA cyclase; RNA terminal phosphate cyclase domain 1; RNA terminal phosphate cyclase domain-containing protein 1; RNA-3'-phosphate cyclase", "tax_id": 10090, "disease": "", "pathway": " (mmu:66368)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25961792;37507081", "class_list": "", "function": "Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA (By similarity). The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product (By similarity). Likely functions in some aspects of cellular RNA processing (PubMed:25961792). Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury (PubMed:25961792)., [UniProtKB, UniProtKB, PubMed]; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. Likely functions in some aspects of cellular RNA processing. Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVV2", "ec_number_list": "6.5.1.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0003963 RNA-3'-phosphate cyclase activity;GO:0003824 catalytic activity;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006396 RNA processing;GO:1905592 negative regulation of optical nerve axon regeneration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D7H3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2X2-1", "uniprot_id": "RBM48_MOUSE", "mass": 41633.0, "length": 371, "protein_name": "RNA-binding protein 48", "gene_name": "Rbm48", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rbm48; C030048B08Rik", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA-binding protein 48", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:269623)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQM1;Q8C9L5", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0071018 U12-type catalytic step 2 spliceosome;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K2X2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q925U0-1", "uniprot_id": "OOSP1_MOUSE", "mass": 23013.0, "length": 202, "protein_name": "Oocyte-secreted protein 1", "gene_name": "Oosp1", "organism": "Mouse", "refseq_name": "oocyte-secreted protein 1 precursor", "refseq_ac": "NP_579931", "gene_names_uniprotkb": "Oosp1; If3", "gene_names_refseq": "Oosp1", "protein_names_uniprotkb": "Oocyte-secreted protein 1; Initiate factor 3", "protein_names_refseq": "initiate factor 3; oocyte secretory protein 1; oocyte-secreted protein 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:170834)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11747200;12237121;21750661", "class_list": "", "function": "May be involved in cell differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSD1;Q8K4N9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0001824 blastocyst development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q925U0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG58-1", "uniprot_id": "P4HTM_MOUSE", "mass": 57049.0, "length": 503, "protein_name": "Transmembrane prolyl 4-hydroxylase", "gene_name": "P4htm", "organism": "Mouse", "refseq_name": "transmembrane prolyl 4-hydroxylase isoform 1", "refseq_ac": "NP_083220", "gene_names_uniprotkb": "P4htm; Ph4", "gene_names_refseq": "4933406E20Rik; HIF-PH4; HPH-4; P4H-TM; P4htm; Ph-4", "protein_names_uniprotkb": "Transmembrane prolyl 4-hydroxylase; 1.14.11.29; HIF-PH4; HIF-prolyl hydroxylase 4; HPH-4; Hypoxia-inducible factor prolyl hydroxylase 4; P4H-TM", "protein_names_refseq": "HIF-prolyl hydroxylase 4; hypoxia-inducible factor prolyl hydroxylase 4; transmembrane prolyl 4-hydroxylase isoform 1; transmembrane prolyl 4-hydroxylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:74443)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;20075561;20185832;21750661;27466183;30899004;31029587;34887587", "class_list": "", "function": "Adiponectin increases collagen production by inducing the expression of P4H, which may play a major role in the development of the thick fibrous cap of advanced atherosclerotic plaque, [RefSeq, PubMed]; Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex., [UniProtKB, UniProtKB]; Chronic stabilization of Hif-1alpha and Hif-2alpha by genetic knockdown of Hif-p4h-2 promotes cardioprotection by induction of many genes involved in glucose metabolism, cardiac function, and blood pressure., [RefSeq, PubMed]; Results show that P4h-tm is expressed to a high degree in the mouse retinal pigment epithelium (RPE) and brain. P4h-tm-/- mice develop age-related renal dysfunction, resulting in proteinuria and impaired RPE functions, which eventually lead to an AMD-like pathology., [RefSeq, PubMed]; The knock-out of P4H-TM was linked to decreased fear and anxiety and increased social behavior., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8CAF1;Q9D499", "ec_number_list": "1.14.11.29;1.14.11.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0031418 L-ascorbic acid binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045646 regulation of erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8BG58-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VC52-1", "uniprot_id": "RBPS2_MOUSE", "mass": 22463.0, "length": 206, "protein_name": "RNA-binding protein with multiple splicing 2", "gene_name": "Rbpms2", "organism": "Mouse", "refseq_name": "RNA-binding protein with multiple splicing 2", "refseq_ac": "NP_082306", "gene_names_uniprotkb": "Rbpms2", "gene_names_refseq": "2400008B06Rik; Rbpms2", "protein_names_uniprotkb": "RNA-binding protein with multiple splicing 2", "protein_names_refseq": "RNA-binding protein with multiple splicing 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:71973)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17242355;21750661;25605945;34428180;37573751;40997131", "class_list": "", "function": "Maternal RNA binding protein with multiple splicing 2 (RBPMS2) is involved in mouse blastocyst formation through the bone morphogenetic protein pathway., [RefSeq, PubMed]; RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (By similarity). Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway. Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells (By similarity). Acts as a pre-mRNA alternative splicing regulator. Mediates ACTN1 and FLNB alternative splicing (By similarity). Likely binds to mRNA tandem CAC trinucleotide or CA dinucleotide motifs (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0048661 positive regulation of smooth muscle cell proliferation;GO:0030514 negative regulation of BMP signaling pathway;GO:0051151 negative regulation of smooth muscle cell differentiation;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0048557 embryonic digestive tract morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VC52-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JZV4-1", "uniprot_id": "RBM41_MOUSE", "mass": 47515.0, "length": 413, "protein_name": "RNA-binding protein 41", "gene_name": "Rbm41", "organism": "Mouse", "refseq_name": "RNA-binding protein 41 isoform 1", "refseq_ac": "NP_001165618", "gene_names_uniprotkb": "Rbm41", "gene_names_refseq": "D330023I21Rik; Rbm41", "protein_names_uniprotkb": "RNA-binding protein 41; RNA-binding motif protein 41", "protein_names_refseq": "RNA-binding protein 41 isoform 1; RNA-binding protein 41", "tax_id": 10090, "disease": "", "pathway": " (mmu:237073)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May bind RNA., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AG07;Q3TMC8;Q3TPC6;Q8C9Y2", "ec_number_list": "", "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0030626 U12 snRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005689 U12-type spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8JZV4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VE52-1", "uniprot_id": "OGRL1_MOUSE", "mass": 52268.0, "length": 464, "protein_name": "Opioid growth factor receptor-like protein 1", "gene_name": "Ogfrl1", "organism": "Mouse", "refseq_name": "opioid growth factor receptor-like protein 1 isoform 2", "refseq_ac": "NP_001074548", "gene_names_uniprotkb": "Ogfrl1", "gene_names_refseq": "2210417C17Rik; Ogfrl1", "protein_names_uniprotkb": "Opioid growth factor receptor-like protein 1", "protein_names_refseq": "opioid growth factor receptor-like protein 1 isoform 2; opioid growth factor receptor-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70155)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;32848054;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0140625 opioid growth factor receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VE52-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2H2-1", "uniprot_id": "OTU6B_MOUSE", "mass": 33758.0, "length": 294, "protein_name": "Deubiquitinase OTUD6B", "gene_name": "Otud6b", "organism": "Mouse", "refseq_name": "deubiquitinase OTUD6B isoform 1", "refseq_ac": "NP_690025", "gene_names_uniprotkb": "Otud6b", "gene_names_refseq": "2600013N14Rik; Otud6b", "protein_names_uniprotkb": "Deubiquitinase OTUD6B; 3.4.19.12; OTU domain-containing protein 6B", "protein_names_refseq": "OTU domain-containing protein 6B; deubiquitinase OTUD6B isoform 1; deubiquitinase OTUD6B; ortholog of human CGI-77", "tax_id": 10090, "disease": "", "pathway": " (mmu:72201)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21267069;21750661;28343629", "class_list": "", "function": "Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (By similarity). May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (By similarity). May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (By similarity). May also play a role in proteasome assembly and function (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AP24;Q3T9X5;Q3U1R9", "ec_number_list": "", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0016281 eukaryotic translation initiation factor 4F complex", "go_biological_process": "GO:0006508 proteolysis;GO:0008283 cell population proliferation;GO:0016579 protein deubiquitination;GO:0017148 negative regulation of translation;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K2H2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BH10-1", "uniprot_id": "ORAI2_MOUSE", "mass": 28199.0, "length": 250, "protein_name": "Protein orai-2", "gene_name": "Orai2", "organism": "Mouse", "refseq_name": "protein orai-2", "refseq_ac": "NP_848866", "gene_names_uniprotkb": "Orai2; Tmem142b", "gene_names_refseq": "A730041O15Rik; Orai2; Tmem142b", "protein_names_uniprotkb": "Protein orai-2; Transmembrane protein 142B", "protein_names_refseq": "calcium release-activated calcium channel 2; protein orai-2; transmembrane protein 142B", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:269717)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;23878235;25673771;35506586;36012752", "class_list": "", "function": "Blockade of Platelet Glycoprotein Ibalpha Augments Neuroprotection in Orai2-Deficient Mice during Middle Cerebral Artery Occlusion. Publication Status: Online-Only, [RefSeq, PubMed]; Data indicate that the Ca(2+) release-activated Ca(2+) channels (CRAC) blocker GSK-7975A inhibited store-operated Ca(2+) entry in a concentration-dependent manner., [RefSeq, PubMed]; Orai2 channel regulates prostaglandin E2 production in TNFalpha/IL1alpha-stimulated astrocytes., [RefSeq, PubMed]; Pore-forming subunit of inward rectifying Ca(2+) release-activated Ca(2+) (CRAC) channels. Assembles with ORAI1 and ORAI3 to form hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor STIM1, a process known as store-operated Ca(2+) entry (SOCE). Various pore subunit combinations may account for distinct CRAC channel spatiotemporal and cell-type specific dynamics. ORAI1 mainly contributes to the generation of Ca(2+) plateaus involved in sustained Ca(2+) entry and is dispensable for cytosolic Ca(2+) oscillations, whereas ORAI2 and ORAI3 generate oscillatory patterns. CRAC channels assemble in Ca(2+) signaling microdomains where Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT transcription factors recruited to ORAI1 via AKAP5. CRAC channels are the main pathway for Ca(2+) influx in T cells and promote the immune response to pathogens by activating NFAT-dependent cytokine and chemokine transcription., [UniProtKB, UniProtKB]; The data from this study indicate that upregulation of STIM2 and Orai2 is involved in the phenotypic transition of pulmonary arterial smooth muscle cells from a contractile state to a proliferative state., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C953", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0015279 store-operated calcium channel activity;GO:0005262 calcium channel activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0002115 store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BH10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BK62-1", "uniprot_id": "OLFL3_MOUSE", "mass": 45746.0, "length": 406, "protein_name": "Olfactomedin-like protein 3", "gene_name": "Olfml3", "organism": "Mouse", "refseq_name": "olfactomedin-like protein 3 precursor", "refseq_ac": "NP_598620", "gene_names_uniprotkb": "Olfml3", "gene_names_refseq": "2810002E22Rik; HNOEL-iso; ONT3; Olfml3; mONT3", "protein_names_uniprotkb": "Olfactomedin-like protein 3", "protein_names_refseq": "olfactomedin-like protein 3 precursor; olfactomedin-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:99543)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;25428507;30084848;30779550;32997357;34428180;34884869", "class_list": "", "function": "Microglia-Derived Olfactomedin-like 3 Promotes Pro-Tumorigenic Microglial Function and Malignant Features of Glioma Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Olfactomedin-like 3 promotes PDGF-dependent pericyte proliferation and migration during embryonic blood vessel formation., [RefSeq, PubMed]; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A9R9W9;Q3V2F2;Q8C1T0;Q99K37", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BK62-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q505D7-1", "uniprot_id": "OPA3_MOUSE", "mass": 20110.0, "length": 179, "protein_name": "Optic atrophy 3 protein homolog", "gene_name": "Opa3", "organism": "Mouse", "refseq_name": "optic atrophy 3 protein homolog", "refseq_ac": "NP_997408", "gene_names_uniprotkb": "Opa3", "gene_names_refseq": "D630048P19Rik; Gm1425; Gm472; Opa3", "protein_names_uniprotkb": "Optic atrophy 3 protein homolog", "protein_names_refseq": "optic atrophy 3 protein homolog", "tax_id": 10090, "disease": "3-methylglutaconic aciduria type 3 (Disease Ontology:DOID:0110004); optic atrophy 3 (Disease Ontology:DOID:0111433)", "pathway": " (mmu:403187)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18222992;21613372;21750661;22869679;27106103;31219806;34428180;37453647", "class_list": "", "function": "May play some role in mitochondrial processes., [UniProtKB, UniProtKB, UniProtKB]; Mutant Opa3 protein retains its mitochondrial localization and induces disrupted mitochondrial morphology. Opa3 accumulates in the lens. The results may reflect a slow turnover of Opa3 protein in vivo and may be important in normal lens physiology. Publication Status: Online-Only, [RefSeq, PubMed]; Opa3(L122P) mice displayed craniofacial abnormalities, including undergrowth of the lower mandible, accompanied in some individuals by cranial asymmetry and incisor malocclusion, [RefSeq, PubMed]; Opa3, a novel regulator of mitochondrial function, controls thermogenesis and abdominal fat mass in a mouse model for Costeff syndrome., [RefSeq, PubMed]; To investigate the OPA3 function we have generated a novel ENU-induced mutant mouse carrying a missense mutation in the OPA3 gene. In the heterozygous state, the mice appear uncompromised. In the homozygous state mice display some of the features of MGA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C6Z9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0040008 regulation of growth;GO:0050905 neuromuscular process;GO:0019216 regulation of lipid metabolic process;GO:0007601 visual perception;GO:0045444 fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q505D7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63850-1", "uniprot_id": "NUP62_MOUSE", "mass": 53255.0, "length": 526, "protein_name": "Nuclear pore glycoprotein p62", "gene_name": "Nup62", "organism": "Mouse", "refseq_name": "nuclear pore glycoprotein p62", "refseq_ac": "NP_444304", "gene_names_uniprotkb": "Nup62", "gene_names_refseq": "D7Ertd649e; Nup62; Nupc1; p62", "protein_names_uniprotkb": "Nuclear pore glycoprotein p62; 62 kDa nucleoporin; Nucleoporin Nup62", "protein_names_refseq": "62 kDa nucleoporin; nuclear pore complex 1; nuclear pore glycoprotein p62; nucleoporin Nup62", "tax_id": 10090, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); striatonigral degeneration (Disease Ontology:DOID:4751)", "pathway": " (mmu:18226); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885)", "pathway_count": 18, "publication_count": 22, "publication_id_list": "19144319;1915419;20665223;21183079;21540332;21750661;23641069;26031751;29187734;31219806;33300544;34428180;34678516;34887587;35820727;35822049;36852467;36908815;37620146;37802024;39927985;40997131", "class_list": "", "function": "Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown., [UniProtKB, UniProtKB]; P62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs and ESC-derived neurons. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-seq reveals Nup62 as a potential regulator for cell division after traumatic brain injury in mice hippocampus. Publication Status: Online-Only, [RefSeq, PubMed]; S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q99JN7", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0051425 PTB domain binding;GO:0044877 protein-containing complex binding;GO:0042169 SH2 domain binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0046601 positive regulation of centriole replication;GO:0046580 negative regulation of Ras protein signal transduction;GO:1903438 positive regulation of mitotic cytokinetic process;GO:0006913 nucleocytoplasmic transport;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q63850-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810P2-1", "uniprot_id": "CMA1C_MOUSE", "mass": 31064.0, "length": 275, "protein_name": "Ciliary microtubule-associated protein 1C", "gene_name": "Cimap1c", "organism": "Mouse", "refseq_name": "ciliary microtubule-associated protein 1C isoform 2", "refseq_ac": "NP_941075", "gene_names_uniprotkb": "Cimap1c; Odf3l1", "gene_names_refseq": "Cimap1c; Gm1116; Odf3l1", "protein_names_uniprotkb": "Ciliary microtubule-associated protein 1C; Outer dense fiber protein 3-like protein 1; Protein CIMAP1C", "protein_names_refseq": "ciliary microtubule-associated protein 1C isoform 2; outer dense fiber of sperm tails 3-like 1; outer dense fiber protein 3-like protein 1; protein CIMAP1C", "tax_id": 10090, "disease": "", "pathway": " (mmu:382075)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20485683;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q810P2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWU9-1", "uniprot_id": "NUP37_MOUSE", "mass": 36732.0, "length": 326, "protein_name": "Nucleoporin Nup37", "gene_name": "Nup37", "organism": "Mouse", "refseq_name": "nucleoporin Nup37", "refseq_ac": "NP_081467", "gene_names_uniprotkb": "Nup37", "gene_names_refseq": "2410003L22Rik; 2810039M17Rik; Nup37", "protein_names_uniprotkb": "Nucleoporin Nup37; Nup107-160 subcomplex subunit Nup37", "protein_names_refseq": "nucleoporin Nup37; nup107-160 subcomplex subunit Nup37", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 24 (Disease Ontology:DOID:0051035)", "pathway": " (mmu:69736); (R-MMU-141430); (R-MMU-141444); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9615933); (R-MMU-9648025)", "pathway_count": 26, "publication_count": 2, "publication_id_list": "21750661;35583302", "class_list": "", "function": "Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation (By similarity)., [UniProtKB]; Nucleoporin37 may play a role in early embryo development in human and mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZ80", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0000776 kinetochore", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0007059 chromosome segregation;GO:0015031 protein transport;GO:0051301 cell division;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CWU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D3S5-1", "uniprot_id": "NXRD1_MOUSE", "mass": 41666.0, "length": 366, "protein_name": "NADP-dependent oxidoreductase domain-containing protein 1", "gene_name": "Noxred1", "organism": "Mouse", "refseq_name": "NADP-dependent oxidoreductase domain-containing protein 1", "refseq_ac": "NP_082020", "gene_names_uniprotkb": "Noxred1", "gene_names_refseq": "4933437F05Rik; Noxred1", "protein_names_uniprotkb": "NADP-dependent oxidoreductase domain-containing protein 1; 1.-.-.-; Pyrroline-5-carboxylate reductase-like protein C14orf148 homolog", "protein_names_refseq": "NADP-dependent oxidoreductase domain-containing protein 1; pyrroline-5-carboxylate reductase-like protein C14orf148 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:71275)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30084848", "class_list": "", "function": "Probable oxidoreductase., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004735 pyrroline-5-carboxylate reductase activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "", "go_biological_process": "GO:0055129 L-proline biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D3S5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGX4-1", "uniprot_id": "OFCC1_MOUSE", "mass": 18233.0, "length": 166, "protein_name": "Orofacial cleft 1 candidate gene 1 protein homolog", "gene_name": "Ofcc1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ofcc1", "gene_names_refseq": "", "protein_names_uniprotkb": "Orofacial cleft 1 candidate gene 1 protein homolog; Orofacial clefting chromosomal breakpoint region candidate 1 protein homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15218257;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0015630 microtubule cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BGX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPX8-1", "uniprot_id": "OOG2_MOUSE", "mass": 55091.0, "length": 476, "protein_name": "Oogenesin-2", "gene_name": "Oog2", "organism": "Mouse", "refseq_name": "oogenesin-2", "refseq_ac": "NP_941063", "gene_names_uniprotkb": "Oog2", "gene_names_refseq": "Oog2", "protein_names_uniprotkb": "Oogenesin-2", "protein_names_refseq": "oogenesin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:381570)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14675769;19480014;21750661;30059200;34428180;35820727", "class_list": "", "function": "RT-PCR data shows an increase in oogenesis specific gene transcripts (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) between the primordial until the preantral stages, with the exception of the Oogenesin1 transcripts under gonadotropin-induction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045596 negative regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TPX8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922W5-1", "uniprot_id": "P5CR1_MOUSE", "mass": 32373.0, "length": 309, "protein_name": "Pyrroline-5-carboxylate reductase 1, mitochondrial", "gene_name": "Pycr1", "organism": "Mouse", "refseq_name": "pyrroline-5-carboxylate reductase 1, mitochondrial isoform b", "refseq_ac": "NP_001335151", "gene_names_uniprotkb": "Pycr1", "gene_names_refseq": "P5CR 1; P5CR1; Pycr1", "protein_names_uniprotkb": "Pyrroline-5-carboxylate reductase 1, mitochondrial; 1.5.1.2; P5C reductase 1; P5CR 1", "protein_names_refseq": "P5C reductase 1; pyrroline-5-carboxylate reductase 1, mitochondrial isoform b; pyrroline-5-carboxylate reductase 1, mitochondrial", "tax_id": 10090, "disease": "autosomal recessive cutis laxa type IIB (Disease Ontology:DOID:0070137); autosomal recessive cutis laxa type IIIB (Disease Ontology:DOID:0070138)", "pathway": " (mmu:209027); (R-MMU-8964539)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "19648921;21750661;31219806;36994814;37293856;39025723", "class_list": "", "function": "A micropeptide TREMP encoded by lincR-PPP2R5C promotes Th2 cell differentiation by interacting with PYCR1 in allergic airway inflammation., [RefSeq, PubMed]; Exosomes from PYCR1 knockdown bone marrow mesenchymal stem inhibits aerobic glycolysis and the growth of bladder cancer cells via regulation of the EGFR/PI3K/AKT pathway., [RefSeq, PubMed]; LINC01123 acts as an oncogenic driver in lung adenocarcinoma by regulating the miR-4766-5p/PYCR1 axis., [RefSeq, PubMed]; Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H. At physiologic concentrations, has higher specific activity in the presence of NADH. Involved in the cellular response to oxidative stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.5.1.2", "go_molecular_function": "GO:0004735 pyrroline-5-carboxylate reductase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:1902792 pyrroline-5-carboxylate reductase complex", "go_biological_process": "GO:0051881 regulation of mitochondrial membrane potential;GO:0034599 cellular response to oxidative stress;GO:0055129 L-proline biosynthetic process;GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q922W5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80Z25-1", "uniprot_id": "OFD1_MOUSE", "mass": 117345.0, "length": 1017, "protein_name": "Centriole and centriolar satellite protein OFD1", "gene_name": "Ofd1", "organism": "Mouse", "refseq_name": "centriole and centriolar satellite protein OFD1 isoform 1", "refseq_ac": "NP_803178", "gene_names_uniprotkb": "Ofd1", "gene_names_refseq": "Cxorf5; DXGgc7e; ORF2; Ofd1", "protein_names_uniprotkb": "Centriole and centriolar satellite protein OFD1; Oral-facial-digital syndrome 1 protein homolog", "protein_names_refseq": "centriole and centriolar satellite protein OFD1 isoform 1; centriole and centriolar satellite protein OFD1; oral-facial-digital syndrome 1 gene homolog; oral-facial-digital syndrome 1 protein homolog", "tax_id": 10090, "disease": "orofaciodigital syndrome I (Disease Ontology:DOID:0060316); Simpson-Golabi-Behmel syndrome type 2 (Disease Ontology:DOID:0080342); retinitis pigmentosa 23 (Disease Ontology:DOID:0110412); Joubert syndrome 10 (Disease Ontology:DOID:0110981); retinitis pigmentosa (Disease Ontology:DOID:10584); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:237222); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5610787); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 9, "publication_count": 12, "publication_id_list": "12782125;16311594;18084282;20230748;21183079;21750661;24089205;25428506;26643951;30084848;34418053;34428180", "class_list": "", "function": "Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation., [UniProtKB, PubMed, PubMed]; The mouse Ofd1 gene is subject to X-inactivation, in contrast to the human gene; a role for Ofd1 in the pathogenesis of the spontaneous mouse mutant Xpl was excluded; evolutionarily conserved domains in the protein were identified., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0043014 alpha-tubulin binding;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005929 cilium;GO:0031514 motile cilium", "go_biological_process": "GO:0010172 embryonic body morphogenesis;GO:2000314 negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation;GO:0060271 cilium assembly;GO:0035082 axoneme assembly;GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q80Z25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99J31-1", "uniprot_id": "OPHN1_MOUSE", "mass": 91985.0, "length": 802, "protein_name": "Oligophrenin-1", "gene_name": "Ophn1", "organism": "Mouse", "refseq_name": "oligophrenin-1 isoform a", "refseq_ac": "NP_001300683", "gene_names_uniprotkb": "Ophn1", "gene_names_refseq": "C130037N19Rik; Ophn1; Wtgr", "protein_names_uniprotkb": "Oligophrenin-1", "protein_names_refseq": "oligophrenin-1 isoform a", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); Billuart-type X-linked syndromic intellectual developmental disorder (Disease Ontology:DOID:0080311)", "pathway": " (mmu:94190); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013408); (R-MMU-9013409); (R-MMU-9013423)", "pathway_count": 11, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12932438;17728457;19401298;19481455;21750661;21874017;33376209;33831348;34428180;34738630;35563851", "class_list": "", "function": "Altered Cl(-) homeostasis hinders forebrain GABAergic interneuron migration in a mouse model of intellectual disability., [RefSeq, PubMed]; Androgen deprivationinduced OPHN1 amplification promotes castrationresistant prostate cancer., [RefSeq, PubMed]; Hippocampal Excitatory Synaptic Transmission and Plasticity Are Differentially Altered during Postnatal Development by Loss of the X-Linked Intellectual Disability Protein Oligophrenin-1. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of OPHN1 leads to the activation of the RhoA/ROCK signaling pathway., [RefSeq, PubMed]; Oligophrenin-1 is expressed in developing CNS areas that evince synaptic plasticity. OPHN1 is expressed in both glial and neuronal cells, where it colocalizes with actin at the tip of growing neurites., [RefSeq, PubMed]; Oligophrenin-1 moderates behavioral responses to stress by regulating parvalbumin interneuron activity in the medial prefrontal cortex., [RefSeq, PubMed]; Results sugest that reduced or defective OPHN1 signaling impairs synaptic vesicle cycling at hippocampal synapses., [RefSeq, PubMed]; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals (By similarity). Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation., [UniProtKB, PubMed]; This study indicates that cognitive impairment related to OPHN1 loss of function is associated with both presynaptic and postsynaptic alterations., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q544K7", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005096 GTPase activator activity;GO:0005543 phospholipid binding;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0030425 dendrite;GO:0043195 terminal bouton", "go_biological_process": "GO:0007165 signal transduction;GO:0030100 regulation of endocytosis;GO:0031175 neuron projection development;GO:0034329 cell junction assembly;GO:0045198 establishment of epithelial cell apical/basal polarity", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q99J31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUV0-1", "uniprot_id": "ORC5_MOUSE", "mass": 50217.0, "length": 435, "protein_name": "Origin recognition complex subunit 5", "gene_name": "Orc5", "organism": "Mouse", "refseq_name": "origin recognition complex subunit 5 isoform 1", "refseq_ac": "NP_036089", "gene_names_uniprotkb": "Orc5; Orc5l", "gene_names_refseq": "MmORC5; Orc5l; Orc5", "protein_names_uniprotkb": "Origin recognition complex subunit 5", "protein_names_refseq": "origin recognition complex subunit 5 isoform 1; origin recognition complex, subunit 5 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:26429); (R-MMU-176187); (R-MMU-68616); (R-MMU-68689); (R-MMU-68949); (R-MMU-68962)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "10460412;21750661;25428506;30084848;30779550;31219806;36210013", "class_list": "", "function": "Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMI6", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin;GO:0005664 nuclear origin of replication recognition complex;GO:0000808 origin recognition complex", "go_biological_process": "GO:0006260 DNA replication;GO:0006275 regulation of DNA replication;GO:0006270 DNA replication initiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WUV0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62010-1", "uniprot_id": "OVGP1_MOUSE", "mass": 78808.0, "length": 721, "protein_name": "Oviduct-specific glycoprotein", "gene_name": "Ovgp1", "organism": "Mouse", "refseq_name": "oviduct-specific glycoprotein precursor", "refseq_ac": "NP_031722", "gene_names_uniprotkb": "Ovgp1; Chit5; Ogp", "gene_names_refseq": "120kDa; Chit5; MOGP; OGP; Ovgp1; muc9", "protein_names_uniprotkb": "Oviduct-specific glycoprotein; Estrogen-dependent oviduct protein; Oviductal glycoprotein; Oviductin", "protein_names_refseq": "chitinase 5; estrogen-dependent oviduct protein; mucin 9; oviduct glycoprotein OGP; oviduct-specific glycoprotein precursor; oviduct-specific glycoprotein; oviductal glycoprotein 1, 120kD; oviductin", "tax_id": 10090, "disease": "", "pathway": " (mmu:12659); (R-MMU-2534343)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;28229966;30059200;35820727;36172862;7492680", "class_list": "glycogene;glycosylhydrolase", "function": "Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development., [UniProtKB]; In the ovary, Ovgp1 transcripts and protein were detected in the surface epithelium, granulosa cells of the preantral and the antral follicles and corpus luteum. In both, the ovary and oviduct, the expression of Ovgp1 was found to be higher at estrus stage than at diestrus stage. To the best of our knowledge, this is the first study demonstrating the extra-oviductal expression of Ovgp1, [RefSeq, PubMed]; Oviductal Glycoprotein 1 Promotes Hypertension by Inducing Vascular Remodeling Through an Interaction With MYH9., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 50, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004568 chitinase activity;GO:0008061 chitin binding;GO:0008843 endochitinase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0015630 microtubule cytoskeleton;GO:0030133 transport vesicle;GO:0035805 egg coat;GO:0098595 perivitelline space", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0007338 single fertilization;GO:2000360 negative regulation of binding of sperm to zona pellucida;GO:0006032 chitin catabolic process;GO:0000272 polysaccharide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q62010-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K010-1", "uniprot_id": "OPLA_MOUSE", "mass": 137611.0, "length": 1288, "protein_name": "5-oxoprolinase", "gene_name": "Oplah", "organism": "Mouse", "refseq_name": "5-oxoprolinase", "refseq_ac": "NP_694762", "gene_names_uniprotkb": "Oplah", "gene_names_refseq": "1700010G02Rik; 5-OPase; Oplah", "protein_names_uniprotkb": "5-oxoprolinase; 3.5.2.9; 5-OPase; 5-oxo-L-prolinase; Pyroglutamase", "protein_names_refseq": "5-oxo-L-prolinase; 5-oxoprolinase; pyroglutamase", "tax_id": 10090, "disease": "", "pathway": " (mmu:75475); (R-MMU-174403)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;20413906;21750661;25428506;29118264;30032247;30084848;31219806;34203471;34428180", "class_list": "", "function": "Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate., [UniProtKB, UniProtKB]; OPLAH depletion occurred as a result of cardiac injury, leading to elevated 5-oxoproline and oxidative stress, whereas OPLAH overexpression improved cardiac function after ischemic injury., [RefSeq, PubMed]; Oplah full body knock-out mice had higher 5-oxoproline levels coupled to increased oxidative stress, myocardial fibrosis and elevated filling pressures reminiscent of heart failure with preserved ejection fraction., [RefSeq, PubMed]; The cause of cellular ATP depletion in nephrotic cystinosis may be the futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3K2", "ec_number_list": "3.5.2.9", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0017168 5-oxoprolinase (ATP-hydrolyzing) activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K010-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920N1-1", "uniprot_id": "CMA1A_MOUSE", "mass": 27650.0, "length": 254, "protein_name": "Ciliary microtubule associated protein 1A", "gene_name": "Cimap1a", "organism": "Mouse", "refseq_name": "ciliary microtubule associated protein 1A", "refseq_ac": "NP_081295", "gene_names_uniprotkb": "Cimap1a; Beta390; Odf3; Shippo1", "gene_names_refseq": "1700011O04Rik; Cimap1a; Odf3; SHIPPO1", "protein_names_uniprotkb": "Ciliary microtubule associated protein 1A; Outer dense fiber of sperm tails protein 3; Outer dense fiber protein 3; Sperm tail protein SHIPPO 1", "protein_names_refseq": "ciliary microtubule associated protein 1A; outer dense fiber of sperm tails 3; outer dense fiber of sperm tails protein 3; outer dense fiber protein 3; sperm tail protein SHIPPO 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69287)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11870087;21750661;37295417", "class_list": "", "function": "Cloning and characterization of shippo 1, a new gene of the mouse testis exclusively transcribed in haploid germ cells, [RefSeq, PubMed]; Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail (PubMed:11870087, PubMed:37295417). May help to maintain the passive elastic structures and elastic recoil of the sperm tail (PubMed:11870087)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAF2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0036126 sperm flagellum", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q920N1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BFU7-1", "uniprot_id": "P2Y10_MOUSE", "mass": 37244.0, "length": 328, "protein_name": "Putative P2Y purinoceptor 10", "gene_name": "P2ry10", "organism": "Mouse", "refseq_name": "putative P2Y purinoceptor 10", "refseq_ac": "NP_766023", "gene_names_uniprotkb": "P2ry10", "gene_names_refseq": "5830408N17Rik; Lypsr2; P2Y10; P2ry10", "protein_names_uniprotkb": "Putative P2Y purinoceptor 10; P2Y10", "protein_names_refseq": "putative P2Y purinoceptor 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:78826); (R-MMU-416476); (R-MMU-417957)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21750661;34815397", "class_list": "", "function": "G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators. Publication Status: Online-Only, [RefSeq, PubMed]; Putative receptor for purines coupled to G proteins., [UniProtKB]; Putative receptor for purines coupled to G-proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2ASC0;Q7TMT1", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BFU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PT54-1", "uniprot_id": "NTCP5_MOUSE", "mass": 48123.0, "length": 434, "protein_name": "Sodium/bile acid cotransporter 5", "gene_name": "Slc10a5", "organism": "Mouse", "refseq_name": "sodium/bile acid cotransporter 5 precursor", "refseq_ac": "NP_001010834", "gene_names_uniprotkb": "Slc10a5; Gm405", "gene_names_refseq": "Gm405; Slc10a5; mP5", "protein_names_uniprotkb": "Sodium/bile acid cotransporter 5; Na(+)/bile acid cotransporter 5; Solute carrier family 10 member 5", "protein_names_refseq": "Na(+)/bile acid cotransporter 5; sodium/bile acid cotransporter 5 precursor; sodium/bile acid cotransporter 5; solute carrier family 10 member 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:241877)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17632081;25428506;34428180", "class_list": "", "function": "Molecular cloning and characterization of SLC10A5 as an orphan carrier with yet non-identified substrates., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EJ85", "ec_number_list": "", "go_molecular_function": "GO:0008508 bile acid:sodium symporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0015721 bile acid and bile salt transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5PT54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SW25-1", "uniprot_id": "P12L2_MOUSE", "mass": 103220.0, "length": 972, "protein_name": "POM121-like protein 2", "gene_name": "Pom121l2", "organism": "Mouse", "refseq_name": "POM121-like protein 2 isoform 1", "refseq_ac": "NP_001156400", "gene_names_uniprotkb": "Pom121l2; Gm24", "gene_names_refseq": "Gm24; Pom121l2", "protein_names_uniprotkb": "POM121-like protein 2", "protein_names_refseq": "POM121 membrane glycoprotein-like 2; POM121-like protein 2 isoform 1; POM121-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:195236)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31219806;35820727", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017056 structural constituent of nuclear pore;GO:0008139 nuclear localization sequence binding", "go_cellular_component": "GO:0005643 nuclear pore", "go_biological_process": "GO:0006405 RNA export from nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5SW25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60715-1", "uniprot_id": "P4HA1_MOUSE", "mass": 60910.0, "length": 534, "protein_name": "Prolyl 4-hydroxylase subunit alpha-1", "gene_name": "P4ha1", "organism": "Mouse", "refseq_name": "prolyl 4-hydroxylase subunit alpha-1 isoform 2 precursor", "refseq_ac": "NP_001303300", "gene_names_uniprotkb": "P4ha1", "gene_names_refseq": "P4ha1; P4ha", "protein_names_uniprotkb": "Prolyl 4-hydroxylase subunit alpha-1; 1.14.11.2; 4-PH alpha-1; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1", "protein_names_refseq": "4-PH alpha-1; procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1; prolyl 4-hydroxylase subunit alpha-1 isoform 2 precursor; prolyl 4-hydroxylase subunit alpha-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18451)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;31219806;32819558;34428180;37828378;37922570;7753822", "class_list": "", "function": "Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Identification and validation of INHBE and P4HA1 as hub genes in non-alcoholic fatty liver disease., [RefSeq, PubMed]; Superoxide-induced Type I collagen secretion depends on prolyl 4-hydroxylases., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEB7;Q80T05;Q91VJ7", "ec_number_list": "1.14.11.2", "go_molecular_function": "GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:0031418 L-ascorbic acid binding;GO:0004656 procollagen-proline 4-dioxygenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0016222 procollagen-proline 4-dioxygenase complex", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q60715-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60890-1", "uniprot_id": "OR2B6_MOUSE", "mass": 35459.0, "length": 313, "protein_name": "Olfactory receptor 2B6", "gene_name": "Or2b6", "organism": "Mouse", "refseq_name": "olfactory receptor 2B6", "refseq_ac": "NP_666753", "gene_names_uniprotkb": "Or2b6; Mor256-11; Olfr11", "gene_names_refseq": "M49; MOR256-11; ORL121; Olfr11; Or2b6", "protein_names_uniprotkb": "Olfactory receptor 2B6; Odorant receptor M49; Olfactory receptor 11; Olfactory receptor 256-11", "protein_names_refseq": "GA_x6K02T2QHY8-11597382-11598323; odorant receptor M49; olfactory receptor 11; olfactory receptor 256-11; olfactory receptor 2B6", "tax_id": 10090, "disease": "", "pathway": " (mmu:218066)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8570653", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQU3;Q8VFH1", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q60890-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62422-1", "uniprot_id": "OSTF1_MOUSE", "mass": 23783.0, "length": 215, "protein_name": "Osteoclast-stimulating factor 1", "gene_name": "Ostf1", "organism": "Mouse", "refseq_name": "osteoclast-stimulating factor 1", "refseq_ac": "NP_059071", "gene_names_uniprotkb": "Ostf1; Sh3d3; Sh3p2", "gene_names_refseq": "Ostf1; SH3P2; Sh3d3", "protein_names_uniprotkb": "Osteoclast-stimulating factor 1; SH3 domain protein 3", "protein_names_refseq": "SH3 domain protein 3; osteoclast-stimulating factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20409); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;18630941;19131326;19144319;21183079;21750661;26740625;32916757;9238627;9630982", "class_list": "", "function": "Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity., [UniProtKB, UniProtKB, UniProtKB]; SH3P2 suppresses osteoclast differentiation through restricting membrane localization of myosin 1E., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UF05", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q62422-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64288-1", "uniprot_id": "OMP_MOUSE", "mass": 18867.0, "length": 163, "protein_name": "Olfactory marker protein", "gene_name": "Omp", "organism": "Mouse", "refseq_name": "olfactory marker protein", "refseq_ac": "NP_035140", "gene_names_uniprotkb": "Omp", "gene_names_refseq": "Omp", "protein_names_uniprotkb": "Olfactory marker protein", "protein_names_refseq": "olfactory marker protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:18378)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12054872;12911636;15198671;8034318;8111122", "class_list": "", "function": "May act as a modulator of the olfactory signal-transduction cascade., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042277 peptide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q64288-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IYF8-1", "uniprot_id": "OXGR1_MOUSE", "mass": 38230.0, "length": 337, "protein_name": "2-oxoglutarate receptor 1", "gene_name": "Oxgr1", "organism": "Mouse", "refseq_name": "2-oxoglutarate receptor 1", "refseq_ac": "NP_001001490", "gene_names_uniprotkb": "Oxgr1; Gpr99", "gene_names_refseq": "Cysltr3; Gm299; Gpr80; Gpr99; Oxgr1; P2Y15", "protein_names_uniprotkb": "2-oxoglutarate receptor 1; Alpha-ketoglutarate receptor 1; G protein-coupled receptor 99", "protein_names_refseq": "2-oxoglutarate receptor 1; G protein-coupled receptor 80; G protein-coupled receptor 99; alpha-ketoglutarate receptor 1", "tax_id": 10090, "disease": "calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652)", "pathway": " (mmu:239283); (R-MMU-373076); (R-MMU-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15001573;15141213;23504326;23934124;27185938;32104923;36919698", "class_list": "", "function": "Exercise-induced alpha-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation. Erratum:[EMBO J. 2021 Jul 15;40(14):e108434. doi: 10.15252/embj.2021108434. PMID: 34263469], [RefSeq, PubMed]; G protein-coupled receptor for dicarboxylates and amino dicarboxylates (PubMed:15141213, PubMed:23504326, PubMed:27185938). Receptor for itaconate produced by activated macrophages upon bacterial infection. In the respiratory epithelium, couples the binding of itaconate to the activation of GNA11 and downstream intracellular Ca(2+) release, leading to mucocilliary clearance of airborne pathogens (PubMed:36919698). Receptor for leukotriene E4 (LTE4) produced by mast cells upon allergic inflammation. Binds with high affinity to LTE4 and elicits mucin release from pulmonary epithelium in response to airborne fungi allergens. Regulates mucin-producing goblet cell homeostasis (PubMed:23504326, PubMed:27185938). Receptor for alpha-ketoglutarate produced by proximal tubule renal cells upon metabolic alkalosis. In an intrarenal paracrine signaling pathway, binds alpha-ketoglutarate and drives transepithelial salt reabsorption and bicarbonate secretion by SLC26A4/pendrin-positive intercalated cells (PubMed:23934124)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand., [RefSeq, PubMed]; P2Y15 is a cell surface receptor for AMP and adenosine, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VEK6;Q3UQE9", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0001609 G protein-coupled adenosine receptor activity;GO:0001883 purine nucleoside binding;GO:0016208 AMP binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0045087 innate immune response;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007208 phospholipase C-activating serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6IYF8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6XBJ3-1", "uniprot_id": "ONEC2_MOUSE", "mass": 54554.0, "length": 505, "protein_name": "One cut domain family member 2", "gene_name": "Onecut2", "organism": "Mouse", "refseq_name": "one cut domain family member 2", "refseq_ac": "NP_919244", "gene_names_uniprotkb": "Onecut2; Oc2", "gene_names_refseq": "C730009D12; OC-2; Oc2; Onecut2", "protein_names_uniprotkb": "One cut domain family member 2; OC-2; One cut homeobox 2; Transcription factor ONECUT-2", "protein_names_refseq": "one cut domain family member 2; one cut homeobox 2; transcription factor ONECUT-2; transcription factor ONECUT2", "tax_id": 10090, "disease": "", "pathway": " (mmu:225631)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12971999;15159395;40997131", "class_list": "", "function": "Although hepatocyte nuclear factor (HNF)6/onecut(OC)-2 and perhaps HNF1 activate the P2 promoter in the embryo, increasing HNF4alpha1 expression throughout development causes a switch to essentially exclusive P1 promoter activity in the adult liver, [RefSeq, PubMed]; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B (By similarity)., [UniProtKB]; We describe here the cloning of mouse (m) OC-2 and its expression pattern in the mouse embryo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030335 positive regulation of cell migration;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6XBJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q78XF5-1", "uniprot_id": "OSTC_MOUSE", "mass": 16815.0, "length": 149, "protein_name": "Oligosaccharyltransferase complex subunit OSTC", "gene_name": "Ostc", "organism": "Mouse", "refseq_name": "oligosaccharyltransferase complex subunit OSTC", "refseq_ac": "NP_079785", "gene_names_uniprotkb": "Ostc", "gene_names_refseq": "2310008M10Rik; 5730557H03Rik; Ostc", "protein_names_uniprotkb": "Oligosaccharyltransferase complex subunit OSTC", "protein_names_refseq": "oligosaccharyltransferase complex subunit OSTC", "tax_id": 10090, "disease": "", "pathway": " (mmu:66357); (R-MMU-9768727); (R-MMU-9931295)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "24751383;30779550;31219806;34428180;35820727;37453647", "class_list": "", "function": "Subunit of STT3A-containing oligosaccharyl transferase (OST-A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1., [UniProtKB, UniProtKB]; These results suggest that the upregulation of OSTC/DC2, a novel component of the oligosaccharyltransferase complex, is part of the mammalian heat shock response., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CPZ2", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex;GO:0160226 oligosaccharyltransferase complex A", "go_biological_process": "GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q78XF5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7M761-1", "uniprot_id": "OVCH2_MOUSE", "mass": 67611.0, "length": 609, "protein_name": "Ovochymase-2", "gene_name": "Ovch2", "organism": "Mouse", "refseq_name": "ovochymase-2 precursor", "refseq_ac": "NP_766496", "gene_names_uniprotkb": "Ovch2; Ovtn", "gene_names_refseq": "9230106D23Rik; Ovch2; Ovtn", "protein_names_uniprotkb": "Ovochymase-2; 3.4.21.-; Oviductin", "protein_names_refseq": "oviductin; ovochymase-2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:244199)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12838346;20810007;32499443;37551853", "class_list": "", "function": "CUB domains are not required for OVCH2 function in sperm maturation in the mouse epididymis., [RefSeq, PubMed]; May be required for sperm ADAM3 processing and consequential sperm fertilizing ability (PubMed:32499443). In vitro, has an endopeptidase activity (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZQ8", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0009566 fertilization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7M761-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TR96-1", "uniprot_id": "O9G19_MOUSE", "mass": 34324.0, "length": 305, "protein_name": "Olfactory receptor 9G19", "gene_name": "Or9g19", "organism": "Mouse", "refseq_name": "olfactory receptor 9G19", "refseq_ac": "NP_666973", "gene_names_uniprotkb": "Or9g19; Mor213-2; Olfr1013", "gene_names_refseq": "MOR213-2; Olfr1013; Or9g19", "protein_names_uniprotkb": "Olfactory receptor 9G19; Olfactory receptor 1013; Olfactory receptor 213-2", "protein_names_refseq": "GA_x6K02T2Q125-47248551-47249468; olfactory receptor 1013; olfactory receptor 213-2; olfactory receptor 9G19; olfactory receptor MOR213-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:258757)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VG30", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TR96-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80SX5-1", "uniprot_id": "OTOP2_MOUSE", "mass": 62582.0, "length": 563, "protein_name": "Proton channel OTOP2", "gene_name": "Otop2", "organism": "Mouse", "refseq_name": "proton channel OTOP2", "refseq_ac": "NP_766389", "gene_names_uniprotkb": "Otop2", "gene_names_refseq": "4732464P15; Otop2", "protein_names_uniprotkb": "Proton channel OTOP2; Otopetrin-2", "protein_names_refseq": "proton channel OTOP2", "tax_id": 10090, "disease": "", "pathway": " (mmu:237987)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12651873;25428506;29371428;35920807;37053086", "class_list": "", "function": "Proton-selective ion channel open at neutral pH (PubMed:29371428, PubMed:35920807, PubMed:37053086). Active at neutral and alkaline extracellular pH, likely participates in some alkali-related physiological activities (PubMed:35920807, PubMed:37053086)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CE77", "ec_number_list": "", "go_molecular_function": "GO:0015252 proton channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80SX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80WK2-1", "uniprot_id": "OSTB_MOUSE", "mass": 14684.0, "length": 128, "protein_name": "Organic solute transporter subunit beta", "gene_name": "Slc51b", "organism": "Mouse", "refseq_name": "organic solute transporter subunit beta", "refseq_ac": "NP_849264", "gene_names_uniprotkb": "Slc51b; Ostb", "gene_names_refseq": "Ostb; Slc51b", "protein_names_uniprotkb": "Organic solute transporter subunit beta; OST-beta; Solute carrier family 51 subunit beta", "protein_names_refseq": "OST-beta; Ost beta; organic solute transporter beta; organic solute transporter subunit beta; solute carrier family 51 subunit beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:330962); (R-MMU-159418)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12719432;15563450;16251721;16317684;16357057;16357058;16628672;17650074;21183079;22535958;28455390", "class_list": "", "function": "Co-expression of mouse Ostalpha-Ostbeta, but not the individual subunits, stimulated Na(+)-independent bile acid uptake and the apical-to-basolateral transport of taurocholate, [RefSeq, PubMed]; Data suggest that transport of bile acid taurocholate is retained when OstB is truncated to contain only the transmembrane domain with 15 additional residues on each side and co-expressed with intact OstA (organic solute transporter alpha subunit); shorter fragments of OstB are inactive. Publication Status: Online-Only, [RefSeq, PubMed]; Essential component of the OST-alpha/OST-beta complex, a heterotetramer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:15563450, PubMed:16317684, PubMed:17650074, PubMed:22535958). The OST-alpha/OST-beta complex efficiently transports the major species of bile acids (taurocholate) (PubMed:16317684, PubMed:17650074, PubMed:22535958). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (PubMed:16317684). In the complex, SLC51B/OST-beta promotes the transmembrane translocation of bile acids (By similarity). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (By similarity). Able to transport eicosanoids such as prostaglandin E2 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]; In conclusion, we identified Ost-alpha/Ost-beta as a novel FXR target. Absent Ost-alpha/Ost-beta induction in CA-fed FXR(-/-) animals may contribute to increased liver injury in these animals., [RefSeq, PubMed]; OSTalpha and OSTbeta mRNA levels were induced in the adrenals and kidneys of wild-type, but not FXR-/-, mice, [RefSeq, PubMed]; The selective localization of OSTalpha and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14BU3;Q3V4C1", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0046982 protein heterodimerization activity;GO:0015125 bile acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0015721 bile acid and bile salt transport;GO:0031647 regulation of protein stability;GO:0090314 positive regulation of protein targeting to membrane;GO:0070863 positive regulation of protein exit from endoplasmic reticulum;GO:0010560 positive regulation of glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q80WK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CB27-1", "uniprot_id": "OTU1_MOUSE", "mass": 37485.0, "length": 343, "protein_name": "Ubiquitin thioesterase OTU1", "gene_name": "Yod1", "organism": "Mouse", "refseq_name": "ubiquitin thioesterase OTU1", "refseq_ac": "NP_848806", "gene_names_uniprotkb": "Yod1", "gene_names_refseq": "6330564D18Rik; 9930028C20Rik; Hshin7; Yod1", "protein_names_uniprotkb": "Ubiquitin thioesterase OTU1; 3.4.19.12", "protein_names_refseq": "HIV-induced protein-7-like protease; YOD1 OTU deubiquitinating enzyme 1 homologue; ubiquitin thioesterase OTU1", "tax_id": 10090, "disease": "", "pathway": " (mmu:226418); (R-MMU-5689896)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "23243279;29330040;30952814;31916733;38789414", "class_list": "", "function": "Antigen presenting cells (APCs) that express a catalytically inactive version of the deubiquitylase YOD1 (YOD1-C160S) present exogenous antigens more efficiently to CD8(+) T cells, both in vitro and in vivo., [RefSeq, PubMed]; Findings thus provided novel insights into the regulatory cascade of the cellular antiviral response through YOD1-mediated K63-linked deubiquitination and aggregation of MAVS., [RefSeq, PubMed]; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation., [UniProtKB, UniProtKB]; YOD1 binds to and deubiquitinates neural precursor cell expressed developmentally down-regulated protein 4. YOD1 suppresses NEDD4-induced cell proliferation., [RefSeq, PubMed]; YOD1 levels significantly increase in cells and tissues in response to various pathophysiological conditions., [RefSeq, PubMed]; YOD1 protects against MRSA sepsis-induced DIC through Lys33-linked deubiquitination of NLRP3. Erratum:[Cell Death Dis. 2024 Sep 4;15(9):651. doi: 10.1038/s41419-024-06991-1. PMID: 39231970] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSW9;Q8BPM9;Q8CB24", "ec_number_list": "3.6.4.6;3.4.19.12", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0070536 protein K63-linked deubiquitination;GO:0016236 macroautophagy;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway;GO:0071108 protein K48-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CB27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3K8-1", "uniprot_id": "OPTN_MOUSE", "mass": 67018.0, "length": 584, "protein_name": "Optineurin", "gene_name": "Optn", "organism": "Mouse", "refseq_name": "optineurin", "refseq_ac": "NP_862896", "gene_names_uniprotkb": "Optn", "gene_names_refseq": "4930441O07Rik; FIP2; HYPL; NRP; Optn", "protein_names_uniprotkb": "Optineurin", "protein_names_refseq": "TFIIIA-INTP; optineurin", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 12 (Disease Ontology:DOID:0060203); neuronal intranuclear inclusion disease (Disease Ontology:DOID:0081294); open-angle glaucoma (Disease Ontology:DOID:1067); primary open angle glaucoma (Disease Ontology:DOID:1070); Huntington's disease (Disease Ontology:DOID:12858); low tension glaucoma (Disease Ontology:DOID:13544); bladder neck obstruction (Disease Ontology:DOID:13948); Parkinson's disease (Disease Ontology:DOID:14330); glaucoma (Disease Ontology:DOID:1686); transient cerebral ischemia (Disease Ontology:DOID:224); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); Paget's disease of bone (Disease Ontology:DOID:5408); proteinuria (Disease Ontology:DOID:576); progressive myoclonus epilepsy (Disease Ontology:DOID:891)", "pathway": " (mmu:71648); (R-MMU-2565942); (R-MMU-5205685); (R-MMU-5357905); (R-MMU-5357956); (R-MMU-8854214); (R-MMU-936964); (R-MMU-9824878)", "pathway_count": 8, "publication_count": 10, "publication_id_list": "15607428;16569640;17242355;20388642;21183079;23669351;26677802;27086836;34428180;37802379", "class_list": "", "function": "Mutated form of optineurin, E50K, identified in normal tension loses its ability to translocate to the nucleus and when overexpressed compromises the mitochondrial membrane integrity resulting in cells that are less fit to survive under stress conditions, [RefSeq, PubMed]; Optineurin regulates osteoblast function in an age-dependent fashion in a mouse model of Paget's disease of bone., [RefSeq, PubMed]; Optn colocalizes with vesicular structures near the nucleus and is expressed in anterior segment, retina, and optic nerve blood vessels., [RefSeq, PubMed]; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation. In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ASP3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030424 axon", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K3K8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K557-1", "uniprot_id": "ONEC3_MOUSE", "mass": 49571.0, "length": 490, "protein_name": "One cut domain family member 3", "gene_name": "Onecut3", "organism": "Mouse", "refseq_name": "one cut domain family member 3", "refseq_ac": "NP_631972", "gene_names_uniprotkb": "Onecut3", "gene_names_refseq": "OC-3; Oc3; Onecut3", "protein_names_uniprotkb": "One cut domain family member 3; OC-3; One cut homeobox 3; Transcription factor ONECUT-3", "protein_names_refseq": "one cut domain family member 3; one cut homeobox 3; transcription factor ONECUT-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:246086)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11944891;15381696", "class_list": "", "function": "Hepatocyte nuclear factor-6/Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm, [RefSeq, PubMed]; Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDH9", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K557-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2U6-1", "uniprot_id": "NUDT4_MOUSE", "mass": 20156.0, "length": 179, "protein_name": "Diphosphoinositol polyphosphate phosphohydrolase 2", "gene_name": "Nudt4", "organism": "Mouse", "refseq_name": "diphosphoinositol polyphosphate phosphohydrolase 2 isoform 2", "refseq_ac": "NP_081998", "gene_names_uniprotkb": "Nudt4; Dipp2", "gene_names_refseq": "4933436C10Rik; DIPP-2; DIPP2alpha; DIPP2beta; DIPP2; HDCMB47P; Nudt4", "protein_names_uniprotkb": "Diphosphoinositol polyphosphate phosphohydrolase 2; 3.6.1.52; 3.6.1.61; DIPP-2; Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2; Nucleoside diphosphate-linked moiety X motif 4; Nudix motif 4", "protein_names_refseq": "diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2; diphosphoinositol polyphosphate phosphohydrolase 2 isoform 2; diphosphoinositol polyphosphate phosphohydrolase 2; nucleoside diphosphate-linked moiety X motif 4; nudix (nucleoside diphosphate linked moiety X)-type motif 4; nudix motif 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:71207); (R-MMU-1855167)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21070968", "class_list": "", "function": "Cleaves the beta-phosphate from diphosphoinositol polyphosphates such as PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 (diphosphoinositol tetrakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Diadenosine polyphosphates, particularly Ap6A (P(1),P(6)-bis(5a-adenosyl) hexaphosphate) and Ap5A (P(1),P(5)-bis(5'-adenosyl) pentaphosphate) are downstream effectors of a signaling cascade that regulates cardiac KATP channels, can also be substrates, although with lower preference than the diphosphoinositol polyphosphates. Can also catalyze the hydrolysis of 5-phosphoribose 1-diphosphate, generating the glycolytic activator ribose 1,5-bisphosphate (By similarity). Does not play a role in U8 snoRNA decapping activity (PubMed:16141072). Binds U8 snoRNA (PubMed:16141072)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXB9;Q9D3T6", "ec_number_list": "3.6.1.52;3.6.1.60;3.6.1.61;3.6.1.59;3.6.1.62;3.6.1.10", "go_molecular_function": "GO:0000298 endopolyphosphatase activity;GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity;GO:0034431 bis(5'-adenosyl)-hexaphosphatase activity;GO:0034432 bis(5'-adenosyl)-pentaphosphatase activity;GO:0052845 inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071543 diphosphoinositol polyphosphate metabolic process;GO:1901907 diadenosine pentaphosphate catabolic process;GO:1901909 diadenosine hexaphosphate catabolic process;GO:1901911 adenosine 5'-(hexahydrogen pentaphosphate) catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R2U6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R448-1", "uniprot_id": "OTOSP_MOUSE", "mass": 10185.0, "length": 89, "protein_name": "Otospiralin", "gene_name": "Otos", "organism": "Mouse", "refseq_name": "otospiralin precursor", "refseq_ac": "NP_694754", "gene_names_uniprotkb": "Otos; Ocp10", "gene_names_refseq": "OTOSP; Otos", "protein_names_uniprotkb": "Otospiralin; Organ of Corti 10 kDa protein", "protein_names_refseq": "organ of Corti 10 kDa protein; otospiralin precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:260301)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11880501;15177554;15632083;18832023", "class_list": "", "function": "Collectively, our observations suggest that otospiralin is possibly involved in signaling pathways, and could play a role in repair mechanisms subsequent to an injury in the central nervous system., [RefSeq, PubMed]; Data suggest that impairment of fibrocytes caused by the loss in otospiralin leads to abnormal cochlear physiology and auditory function., [RefSeq, PubMed]; May be essential for the survival of the neurosensory epithelium of the inner ear., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R448-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VBT3-1", "uniprot_id": "OSCAR_MOUSE", "mass": 28726.0, "length": 265, "protein_name": "Osteoclast-associated immunoglobulin-like receptor", "gene_name": "Oscar", "organism": "Mouse", "refseq_name": "osteoclast-associated immunoglobulin-like receptor isoform 2 precursor", "refseq_ac": "NP_001277306", "gene_names_uniprotkb": "Oscar", "gene_names_refseq": "Oscar; mOSCAR-M1; mOSCAR-M2; mOSCAR-M3; mOSCAR", "protein_names_uniprotkb": "Osteoclast-associated immunoglobulin-like receptor; Ocl178; Osteoclast-associated receptor; mOSCAR", "protein_names_refseq": "ocl178; osteoclast-associated immunoglobulin-like receptor isoform 2 precursor; osteoclast-associated immunoglobulin-like receptor; osteoclast-associated receptor OSCAR", "tax_id": 10090, "disease": "", "pathway": " (mmu:232790); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11805147;12695521;15184345;16046394;16109714;21750661;21841309;23817038;32859940", "class_list": "", "function": "Analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1, involving NFATc1-mediated OSCAR expression and its subsequent activation of NFATc1, necessary for efficient differentiation of osteoclasts, [RefSeq, PubMed]; Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice., [RefSeq, PubMed]; OSCAR but not TREM-2 is involved in the positive feedback loop of the immunoreceptor-NFATc1 pathway during osteoclastogenesis, [RefSeq, PubMed]; OSCAR expression in monocytic cells is regulated by proatherogenic stimuli further pointing towards a role in vascular inflammation or plaque vulnerability during atherosclerosis, [RefSeq, PubMed]; Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation. Publication Status: Online-Only, [RefSeq, PubMed]; PU.1 and MITF transcription factors synergistically activate OSCAR gene expression, which is further enhanced by the TRANCE-induced MKK6/p38 signaling cascade., [RefSeq, PubMed]; Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation., [UniProtKB, PubMed]; The FcRgamma-mediated signal transduction by OSCAR is involved in osteoclast differentiation, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8VHT9", "ec_number_list": "", "go_molecular_function": "GO:0038064 collagen receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0038094 Fc-gamma receptor signaling pathway;GO:0030316 osteoclast differentiation;GO:0007165 signal transduction;GO:0045780 positive regulation of bone resorption;GO:0072674 multinuclear osteoclast differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VBT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEY3-1", "uniprot_id": "O10D3_MOUSE", "mass": 34528.0, "length": 312, "protein_name": "Olfactory receptor 10D3", "gene_name": "Or10d3", "organism": "Mouse", "refseq_name": "olfactory receptor 10D3", "refseq_ac": "NP_666442", "gene_names_uniprotkb": "Or10d3; Mor224-9; Olfr958", "gene_names_refseq": "MOR224-9; Olfr958; Or10d3", "protein_names_uniprotkb": "Olfactory receptor 10D3; Olfactory receptor 224-9; Olfactory receptor 958", "protein_names_refseq": "GA_x6K02T2PVTD-33247839-33246901; olfactory receptor 10D3; olfactory receptor 224-9; olfactory receptor 958; olfactory receptor MOR224-9", "tax_id": 10090, "disease": "", "pathway": " (mmu:258327)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VEY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VF12-1", "uniprot_id": "O5P70_MOUSE", "mass": 36873.0, "length": 330, "protein_name": "Olfactory receptor 5P70", "gene_name": "Or5p70", "organism": "Mouse", "refseq_name": "olfactory receptor 5P70", "refseq_ac": "NP_666476", "gene_names_uniprotkb": "Or5p70; Mor204-37; Olfr495", "gene_names_refseq": "MOR204-37; Olfr495; Or5p70", "protein_names_uniprotkb": "Olfactory receptor 5P70; Olfactory receptor 204-37; Olfactory receptor 495", "protein_names_refseq": "GA_x6K02T2PBJ9-10725148-10726140; olfactory receptor 204-37; olfactory receptor 495; olfactory receptor 5P70; olfactory receptor MOR204-37", "tax_id": 10090, "disease": "", "pathway": " (mmu:258361)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VF12-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VF76-1", "uniprot_id": "O5G29_MOUSE", "mass": 35374.0, "length": 314, "protein_name": "Olfactory receptor 5G29", "gene_name": "Or5g29", "organism": "Mouse", "refseq_name": "olfactory receptor 5G29", "refseq_ac": "NP_666647", "gene_names_uniprotkb": "Or5g29; Mor175-5; Olfr998", "gene_names_refseq": "MOR175-5; Olfr998; Or5g29", "protein_names_uniprotkb": "Olfactory receptor 5G29; Olfactory receptor 175-5; Olfactory receptor 998", "protein_names_refseq": "GA_x6K02T2Q125-47069356-47070300; olfactory receptor 175-5; olfactory receptor 5G29; olfactory receptor 998; olfactory receptor MOR175-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:258428)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "28935714", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ALC8", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VF76-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VFD2-1", "uniprot_id": "O5P66_MOUSE", "mass": 34744.0, "length": 314, "protein_name": "Olfactory receptor 5P66", "gene_name": "Or5p66", "organism": "Mouse", "refseq_name": "olfactory receptor 5P66", "refseq_ac": "NP_666709", "gene_names_uniprotkb": "Or5p66; Mor204-17; Olfr490", "gene_names_refseq": "MOR204-17; Olfr490; Or5p66", "protein_names_uniprotkb": "Olfactory receptor 5P66; Olfactory receptor 204-17; Olfactory receptor 490", "protein_names_refseq": "GA_x6K02T2PBJ9-10617173-10616229; olfactory receptor 204-17; olfactory receptor 490; olfactory receptor 5P66; olfactory receptor MOR204-17", "tax_id": 10090, "disease": "", "pathway": " (mmu:258491)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VFD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VFK1-1", "uniprot_id": "OR5G9_MOUSE", "mass": 35458.0, "length": 314, "protein_name": "Olfactory receptor 5G9", "gene_name": "Or5g9", "organism": "Mouse", "refseq_name": "olfactory receptor 5G9", "refseq_ac": "NP_666783", "gene_names_uniprotkb": "Or5g9; Mor175-3; Olfr1009", "gene_names_refseq": "MOR175-3; Olfr1009; Or5g9", "protein_names_uniprotkb": "Olfactory receptor 5G9; Olfactory receptor 1009; Olfactory receptor 175-3", "protein_names_refseq": "GA_x6K02T2Q125-47195323-47196267; olfactory receptor 1009; olfactory receptor 175-3; olfactory receptor 5G9; olfactory receptor MOR175-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:258565)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VFK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VFK2-1", "uniprot_id": "O5G25_MOUSE", "mass": 35833.0, "length": 318, "protein_name": "Olfactory receptor 5G25", "gene_name": "Or5g25", "organism": "Mouse", "refseq_name": "olfactory receptor 5G25", "refseq_ac": "NP_666784", "gene_names_uniprotkb": "Or5g25; Mor175-2; Olfr1002", "gene_names_refseq": "MOR175-2; Olfr1002; Or5g25", "protein_names_uniprotkb": "Olfactory receptor 5G25; Olfactory receptor 1002; Olfactory receptor 175-2", "protein_names_refseq": "GA_x6K02T2Q125-47127746-47126790; olfactory receptor 1002; olfactory receptor 175-2; olfactory receptor 5G25; olfactory receptor MOR175-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:258566)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ALD0", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VFK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VFK7-1", "uniprot_id": "O5AP2_MOUSE", "mass": 35284.0, "length": 317, "protein_name": "Olfactory receptor 5AP2", "gene_name": "Or5ap2", "organism": "Mouse", "refseq_name": "olfactory receptor 5AP2", "refseq_ac": "NP_666791", "gene_names_uniprotkb": "Or5ap2; Mor201-2; Olfr1020", "gene_names_refseq": "MOR201-2; Olfr1020; Or5ap2", "protein_names_uniprotkb": "Olfactory receptor 5AP2; Olfactory receptor 1020; Olfactory receptor 201-2", "protein_names_refseq": "GA_x6K02T2Q125-47327964-47328917; olfactory receptor 1020; olfactory receptor 201-2; olfactory receptor 5AP2; olfactory receptor MOR201-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:258573)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A1L1STE7;Q0VEQ7", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VFK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VFL9-1", "uniprot_id": "OR5T7_MOUSE", "mass": 34661.0, "length": 310, "protein_name": "Olfactory receptor 5T7", "gene_name": "Or5t7", "organism": "Mouse", "refseq_name": "olfactory receptor 5T7", "refseq_ac": "NP_666803", "gene_names_uniprotkb": "Or5t7; Mor179-2; Olfr1086", "gene_names_refseq": "MOR179-2; Olfr1086; Or5t7", "protein_names_uniprotkb": "Olfactory receptor 5T7; Olfactory receptor 1086; Olfactory receptor 179-2", "protein_names_refseq": "GA_x6K02T2Q125-48168771-48167839; olfactory receptor 1086; olfactory receptor 179-2; olfactory receptor 5T7; olfactory receptor MOR179-2; olfactory receptor family 5 subfamily T member 17", "tax_id": 10090, "disease": "", "pathway": " (mmu:258585)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VFL9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VG07-1", "uniprot_id": "O5P69_MOUSE", "mass": 34658.0, "length": 314, "protein_name": "Olfactory receptor 5P69", "gene_name": "Or5p69", "organism": "Mouse", "refseq_name": "olfactory receptor 5P69", "refseq_ac": "NP_666948", "gene_names_uniprotkb": "Or5p69; Mor204-10; Olfr494", "gene_names_refseq": "MOR204-10; Olfr494; Or5p69", "protein_names_uniprotkb": "Olfactory receptor 5P69; Olfactory receptor 204-10; Olfactory receptor 494", "protein_names_refseq": "GA_x6K02T2PBJ9-10697517-10698461; olfactory receptor 204-10; olfactory receptor 494; olfactory receptor 5P69; olfactory receptor MOR204-10", "tax_id": 10090, "disease": "", "pathway": " (mmu:258732)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VG07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VGR9-1", "uniprot_id": "OR8U9_MOUSE", "mass": 35612.0, "length": 314, "protein_name": "Olfactory receptor 8U9", "gene_name": "Or8u9", "organism": "Mouse", "refseq_name": "olfactory receptor 8U9", "refseq_ac": "NP_667222", "gene_names_uniprotkb": "Or8u9; Mor185-4; Olfr1044", "gene_names_refseq": "MOR185-4; Olfr1044; Or8u9", "protein_names_uniprotkb": "Olfactory receptor 8U9; Olfactory receptor 1044; Olfactory receptor 185-4", "protein_names_refseq": "GA_x6K02T2Q125-47640742-47639798; olfactory receptor 1044; olfactory receptor 185-4; olfactory receptor 8U9; olfactory receptor MOR185-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:259013); (R-MMU-381753)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VGR9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VGS3-1", "uniprot_id": "O5AR1_MOUSE", "mass": 34860.0, "length": 310, "protein_name": "Olfactory receptor 5AR1", "gene_name": "Or5ar1", "organism": "Mouse", "refseq_name": "olfactory receptor 5AR1", "refseq_ac": "NP_667226", "gene_names_uniprotkb": "Or5ar1; Mor180-1; Olfr1019", "gene_names_refseq": "MOR180-1; Olfr1019; Or5ar1", "protein_names_uniprotkb": "Olfactory receptor 5AR1; Olfactory receptor 1019; Olfactory receptor 180-1", "protein_names_refseq": "GA_x6K02T2Q125-47320309-47319377; olfactory receptor 1019; olfactory receptor 180-1; olfactory receptor 5AR1; olfactory receptor MOR180-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:259017)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "29659735;32061665;34428180;35820727", "class_list": "", "function": "Olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups such as (methylthio)methanethiol (MTMT). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (Probable)., [UniProtKB, PubMed]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; This odorant receptor, Olfr1019, responds to the odorant undecanal in both in vivo and in vitro assays, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005507 copper ion binding;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0050907 detection of chemical stimulus involved in sensory perception;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VGS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VI94-1", "uniprot_id": "OASL1_MOUSE", "mass": 59088.0, "length": 511, "protein_name": "2'-5'-oligoadenylate synthase-like protein 1", "gene_name": "Oasl1", "organism": "Mouse", "refseq_name": "2'-5'-oligoadenylate synthase-like protein 1 isoform a", "refseq_ac": "NP_660210", "gene_names_uniprotkb": "Oasl1; oasl9", "gene_names_refseq": "7530414C13Rik; Oasl1; oasl9", "protein_names_uniprotkb": "2'-5'-oligoadenylate synthase-like protein 1; 2',5'-oligoadenylate synthetase-like 9", "protein_names_refseq": "2',5'-oligoadenylate synthetase-like 9; 2'-5'-oligoadenylate synthase-like protein 1 isoform a; 2'-5'-oligoadenylate synthase-like protein 1; 2,5-oligoadenylate synthetase-like 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:231655); (R-MMU-8983711)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12080145;12169584;12222967;12396720;12799444;17024523;31219806;34428180;36809539;37453647", "class_list": "", "function": "Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity via an alternative antiviral pathway independent of RNase L., [UniProtKB, PubMed, PubMed]; OASL knockdown inhibits the progression of stomach adenocarcinoma by regulating the mTORC1 signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBP8;Q8K2A2;Q8QZV5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003725 double-stranded RNA binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0070106 interleukin-27-mediated signaling pathway;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0060337 type I interferon-mediated signaling pathway;GO:0009615 response to virus", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VI94-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VI95-1", "uniprot_id": "OAS1D_MOUSE", "mass": 42831.0, "length": 361, "protein_name": "Inactive 2'-5'-oligoadenylate synthase 1D", "gene_name": "Oas1d", "organism": "Mouse", "refseq_name": "inactive 2'-5'-oligoadenylate synthase 1D", "refseq_ac": "NP_598654", "gene_names_uniprotkb": "Oas1d; Oasl8", "gene_names_refseq": "Oas1d; oasl8", "protein_names_uniprotkb": "Inactive 2'-5'-oligoadenylate synthase 1D", "protein_names_refseq": "2',5'-oligoadenylate synthetase-like 8; 2'-5'olygoadenylate synthetase 1D; inactive 2'-5'-oligoadenylate synthase 1D", "tax_id": 10090, "disease": "immunodeficiency 100 (Disease Ontology:DOID:0061070)", "pathway": " (mmu:100535)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12080145;12396720;15899864;17567914;27663720", "class_list": "", "function": "Does not have 2'-5'-oligoadenylate synthetase activity, but can bind double-stranded RNA (PubMed:12396720, PubMed:15899864). May play a role in the control of female fertility, possibly by binding to and inhibiting OAS1A (PubMed:15899864)., [UniProtKB, PubMed, PubMed]; OAS1D suppresses the interferon/OAS/RNase L-mediated cellular destruction by interacting with OAS1A during oogenesis and early embryonic development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UWZ6;Q7TPY2", "ec_number_list": "", "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0003725 double-stranded RNA binding;GO:0001730 2'-5'-oligoadenylate synthetase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0070106 interleukin-27-mediated signaling pathway;GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production;GO:0035457 cellular response to interferon-alpha;GO:0043129 surfactant homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VI95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920A0-1", "uniprot_id": "OPT_MOUSE", "mass": 36422.0, "length": 328, "protein_name": "Opticin", "gene_name": "Optc", "organism": "Mouse", "refseq_name": "opticin isoform 1 precursor", "refseq_ac": "NP_001382487", "gene_names_uniprotkb": "Optc; Opt", "gene_names_refseq": "Optc", "protein_names_uniprotkb": "Opticin; Oculoglycan", "protein_names_refseq": "oculoglycan; opticin isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:269120); (R-MMU-1474228)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11527931;12019215;21750661;22159013;22669977;29237092;29323130;32764753;34428180", "class_list": "", "function": "Analysis of opticin binding to collagen fibrils identifies a single binding site in the gap region and a high specificity towards thin heterotypic fibrils containing collagens II, and XI or V/XI. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (PubMed:22159013). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (PubMed:29323130)., [UniProtKB, UniProtKB, PubMed, PubMed]; Opticin binds to collagen and thereby competitively inhibits endothelial cell interactions with collagen via alpha(1)beta(1) and alpha(2)beta(1) integrins, thereby preventing the strong adhesion that is required for proangiogenic signaling via these integrins., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3K2;Q91ZZ9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0016525 negative regulation of angiogenesis;GO:0060348 bone development;GO:0061975 articular cartilage development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q920A0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921I0-1", "uniprot_id": "ORML1_MOUSE", "mass": 17355.0, "length": 153, "protein_name": "ORM1-like protein 1", "gene_name": "Ormdl1", "organism": "Mouse", "refseq_name": "ORM1-like protein 1", "refseq_ac": "NP_663492", "gene_names_uniprotkb": "Ormdl1", "gene_names_refseq": "C730042F17Rik; Ormdl1", "protein_names_uniprotkb": "ORM1-like protein 1", "protein_names_refseq": "ORM1-like protein 1", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:227102); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "25775599;30084848;30779550;31880535;38715613", "class_list": "glycogene", "function": "Free-cholesterol accumulation diminishes ORMDL1 expression, [RefSeq, PubMed]; Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:31880535). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity)., [UniProtKB, PubMed, UniProtKB]; Simultaneous deletion of ORMDL1 and ORMDL3 proteins disrupts immune cell homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; We found that Ormdl1 and Ormdl3 function redundantly to suppress the levels of bioactive sphingolipid metabolites during myelination of the sciatic nerve Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK13", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1900060 negative regulation of ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0006672 ceramide metabolic process;GO:0090156 intracellular sphingolipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q921I0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPZ6-1", "uniprot_id": "ORML3_MOUSE", "mass": 17477.0, "length": 153, "protein_name": "ORM1-like protein 3", "gene_name": "Ormdl3", "organism": "Mouse", "refseq_name": "ORM1-like protein 3", "refseq_ac": "NP_079937", "gene_names_uniprotkb": "Ormdl3", "gene_names_refseq": "2810011N17Rik; Ormdl3", "protein_names_uniprotkb": "ORM1-like protein 3", "protein_names_refseq": "ORM1-like protein 3", "tax_id": 10090, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); asthma (Disease Ontology:DOID:2841); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (mmu:66612); (R-MMU-1660661); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "23577138;24056518;24623133;25428506;30084848;30700557;31880535;34428180;35820727;37594074;37877592;38081412;38715613", "class_list": "glycogene", "function": "Histone acetylation regulates ORMDL3 expression-mediated NLRP3 inflammasome overexpression during RSV-allergic exacerbation mice., [RefSeq, PubMed]; ORMDL3 promotes eosinophil trafficking and activation via regulation of CD18, CD49d, and CD48., [RefSeq, PubMed]; ORMDL3-mediated bronchial epithelial pyroptosis leads to lung inflammation in obese mice with asthma., [RefSeq, PubMed]; Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis., [RefSeq, PubMed]; Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:30700557, PubMed:31880535). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Signaling pathway cAMP/PKA/CREB plays an important role in regulating ORMDL3 expression, [RefSeq, PubMed]; Simultaneous deletion of ORMDL1 and ORMDL3 proteins disrupts immune cell homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; These studies provide evidence that ORMDL3 plays an important role in vivo in airway remodeling potentially through ATF6 target genes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A4X7;Q8BN65;Q8R0U5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1900060 negative regulation of ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0006672 ceramide metabolic process;GO:0010508 positive regulation of autophagy;GO:1900182 positive regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9CPZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWD3-1", "uniprot_id": "NUD17_MOUSE", "mass": 32681.0, "length": 296, "protein_name": "m7GpppN-mRNA hydrolase NUDT17", "gene_name": "Nudt17", "organism": "Mouse", "refseq_name": "m7GpppN-mRNA hydrolase NUDT17 isoform 2", "refseq_ac": "NP_001156397", "gene_names_uniprotkb": "Nudt17", "gene_names_refseq": "2410015C20Rik; Nudt17", "protein_names_uniprotkb": "m7GpppN-mRNA hydrolase NUDT17; 3.6.1.62; Nucleoside diphosphate-linked moiety X motif 17; Nudix motif 17", "protein_names_refseq": "m7GpppN-mRNA hydrolase NUDT17 isoform 2; m7GpppN-mRNA hydrolase NUDT17; nucleoside diphosphate-linked moiety X motif 17; nudix (nucleoside diphosphate linked moiety X)-type motif 17; nudix motif 17", "tax_id": 10090, "disease": "", "pathway": " (mmu:78373)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;23353937;37507081", "class_list": "", "function": "Acts as a decapping enzyme capable of hydrolyzing monomethylated capped RNAs (in vitro). Hydrolyzes monomethylated capped RNA after alpha and beta phosphates to form N(7)-methyl-GDP. Shows low activity towards unmethylated capped RNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14BX3;Q3URR9", "ec_number_list": "3.6.1.62;3.6.1.64;3.6.1.59;3.6.1.52;3.6.1.10;3.6.1.61", "go_molecular_function": "GO:0046872 metal ion binding;GO:0035529 NADH pyrophosphatase activity;GO:0140933 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0019677 NAD+ catabolic process;GO:0006742 NADP+ catabolic process;GO:0110154 RNA decapping", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CWD3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWE6-1", "uniprot_id": "OOEP_MOUSE", "mass": 18460.0, "length": 164, "protein_name": "Oocyte-expressed protein homolog", "gene_name": "Ooep", "organism": "Mouse", "refseq_name": "oocyte-expressed protein homolog", "refseq_ac": "NP_080756", "gene_names_uniprotkb": "Ooep; Oep19; Sddr", "gene_names_refseq": "2410146L05Rik; Floped; Moep19; Ooep; Sddr", "protein_names_uniprotkb": "Oocyte-expressed protein homolog; Factor located in oocytes permitting embryonic development; Floped; Oocyte- and embryo-specific protein 19; STAT3 downstream gene and differentiation regulator; mOEP19", "protein_names_refseq": "STAT3 downstream gene and differentiation regulator; factor located in oocytes permitting embryonic development; oocyte and embryo specific protein; oocyte expressed protein homolog (dog); oocyte- and embryo-specific protein 19; oocyte-expressed protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67968)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "18191828;18804437;20590823;25208553;28992324;29125140;29955025;31575650;37922900;38177687", "class_list": "", "function": "Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development (PubMed:18804437, PubMed:25208553, PubMed:37922900). The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (PubMed:31575650, PubMed:37922900). They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation (PubMed:37922900). As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (PubMed:29125140). Positively regulates the homologous recombination-mediated DNA double-strand break (DSB) repair pathway by regulating ATM activation and RAD51 recruitment to DSBs in oocytes (PubMed:29955025). Thereby contributes to oocyte survival and the resumption and completion of meiosis (PubMed:29955025)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MOEP19 domain directs RNAs essential for normal embryonic development to specific locations in the oocyte and early embryo., [RefSeq, PubMed]; Results describe a subcortical maternal complex, containing Mater, Floped, TLE6, and Filia, that is essential for preimplantation mouse embryogenesis., [RefSeq, PubMed]; The CES5/OOEP is an essential component of the oocyte cytoplasmic lattices and is required for embryonic development at the maternal-zygotic stage transition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0140094 structural constituent of cytoplasmic lattice", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0045177 apical part of cell;GO:0032991 protein-containing complex", "go_biological_process": "GO:0045836 positive regulation of meiotic nuclear division;GO:0051293 establishment of spindle localization;GO:0001701 in utero embryonic development;GO:0006468 protein phosphorylation;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CWE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DD16-1", "uniprot_id": "NUD22_MOUSE", "mass": 33376.0, "length": 308, "protein_name": "Uridine diphosphate glucose pyrophosphatase NUDT22", "gene_name": "Nudt22", "organism": "Mouse", "refseq_name": "uridine diphosphate glucose pyrophosphatase NUDT22", "refseq_ac": "NP_080951", "gene_names_uniprotkb": "Nudt22", "gene_names_refseq": "0610006K04Rik; Nudt22", "protein_names_uniprotkb": "Uridine diphosphate glucose pyrophosphatase NUDT22; 3.6.1.-; Nucleoside diphosphate-linked moiety X motif 22; Nudix motif 22", "protein_names_refseq": "UDPG pyrophosphatase; UGPPase; nucleoside diphosphate-linked moiety X motif 22; nudix (nucleoside diphosphate linked moiety X)-type motif 22; nudix motif 22; uridine diphosphate glucose pyrophosphatase NUDT22", "tax_id": 10090, "disease": "", "pathway": " (mmu:68323)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Pyrophosphatase hydrolyzing the diphosphate bond in the nucleotide-sugars UDP-glucose and UDP-galactose with a preference for the former, yielding glucose 1-phosphate or galactose 1-phosphate and UMP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCI4", "ec_number_list": "3.6.1.-;3.6.1.13;3.6.1.45", "go_molecular_function": "GO:0008768 UDP-sugar diphosphatase activity;GO:0046872 metal ion binding;GO:0052751 GDP-mannose hydrolase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9DD16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERK9-1", "uniprot_id": "P2RY6_MOUSE", "mass": 36721.0, "length": 328, "protein_name": "P2Y purinoceptor 6", "gene_name": "P2ry6", "organism": "Mouse", "refseq_name": "P2Y purinoceptor 6", "refseq_ac": "NP_898991", "gene_names_uniprotkb": "P2ry6", "gene_names_refseq": "2010204J23Rik; P2Y6; P2ry6", "protein_names_uniprotkb": "P2Y purinoceptor 6; P2Y6", "protein_names_refseq": "P2Y purinoceptor 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:233571); (R-MMU-416476); (R-MMU-417957)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11259526;18250478;18523137;34428180;36835211;38036416;38614103", "class_list": "", "function": "Inflammation up-regulates P2Y2 as well as P2Y6 receptor expression in the colonic mucosa of colitic mice., [RefSeq, PubMed]; Knockout of Purinergic P2Y6 Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis. Publication Status: Online-Only, [RefSeq, PubMed]; Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cbeta/store-operated calcium entry/calreticulin/scavenger receptor A pathways., [RefSeq, PubMed]; Microglial P2Y6 calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis., [RefSeq, PubMed]; P2Y(6)-deficient mice have a defective response to UDP in macrophages, endothelial cells, and vascular smooth muscle cells., [RefSeq, PubMed]; Receptor for extracellular UTP > ADP = 2-methylthio-ATP > ADP-beta-S > ATP = ATP-gamma-S. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Functionally coupled to phospholipase C (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001621 G protein-coupled ADP receptor activity;GO:0019103 pyrimidine nucleotide binding;GO:0045029 G protein-coupled UDP receptor activity;GO:0045030 G protein-coupled UTP receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0032962 positive regulation of inositol trisphosphate biosynthetic process;GO:0007186 G protein-coupled receptor signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0006909 phagocytosis;GO:0071380 cellular response to prostaglandin E stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ERK9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIE3-1", "uniprot_id": "OTOR_MOUSE", "mass": 14328.0, "length": 128, "protein_name": "Otoraplin", "gene_name": "Otor", "organism": "Mouse", "refseq_name": "otoraplin precursor", "refseq_ac": "NP_065620", "gene_names_uniprotkb": "Otor; Mial", "gene_names_refseq": "CDRAP; Fdp; MIAL; MIA; Otor", "protein_names_uniprotkb": "Otoraplin; Melanoma inhibitory activity-like protein", "protein_names_refseq": "melanoma inhibitory activity-like protein; otoraplin precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:57329)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10873378;11161796", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001502 cartilage condensation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JIE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXZ9-1", "uniprot_id": "OPN4_MOUSE", "mass": 57231.0, "length": 521, "protein_name": "Melanopsin", "gene_name": "Opn4", "organism": "Mouse", "refseq_name": "melanopsin isoform 2", "refseq_ac": "NP_001122071", "gene_names_uniprotkb": "Opn4; Mopn; Mop", "gene_names_refseq": "1110007J02Rik; Gm533; Opn4", "protein_names_uniprotkb": "Melanopsin; Opsin-4", "protein_names_refseq": "melanopsin isoform 2; opsin-4", "tax_id": 10090, "disease": "retinitis pigmentosa 4 (Disease Ontology:DOID:0110372); sensorineural hearing loss (Disease Ontology:DOID:10003); retinitis pigmentosa (Disease Ontology:DOID:10584); retinal disease (Disease Ontology:DOID:5679); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:30044); (R-MMU-416476); (R-MMU-419771)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10632589;11834834;12481140;12481141;12808468;19793992;22051675;23049792;23921072;25428506;26392540;30017393;30240620;30936473;31607531;35274137", "class_list": "", "function": "Critical role in circadian photoentrainment, [RefSeq, PubMed]; G protein-coupled photoreceptor that signals through the G(q/11) family of G proteins in response to light in intrinsically photosensitive retinal ganglion cells (ipRGCs) (PubMed:22051675, PubMed:30017393). Can also activate other G proteins, including G(i/o) and G(s), depending on the cell type, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent signaling (PubMed:35274137). Activation occurs when opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade (PubMed:19793992). Acts as a bistable protein, allowing photoreversible regeneration of the cis-retinal chromophore after stimulation (By similarity). Contributes to non-image-forming visual response to light in ipRGCs, including the pupillary light reflex and the regulation of circadian rhythms (PubMed:12808468, PubMed:22051675). In M1 ipRGCs (non-image forming) subtypes, activates a G(q)-phospholipase C (PLC) signaling cascade leading to depolarization through opening of TRPC6/7 channels and decreased intrisic excitability (PubMed:22051675, PubMed:30017393). Mediates phototransduction in M4 ipRGCs (image forming) subtypes across dim to bright light conditions via G(q)-PLC signaling, resulting in increased intrisic excitability through closure of potassium leak channels (most likely TASK channels), thereby enhancing contrast sensitivity (PubMed:30017393). At bright light intensities, further enhances depolarization in M4 ipRGCs via activation of TRPC channels (PubMed:30017393). Functions in the iris to control the intrinsic pupillary light reflex in nocturnal/crepuscular non-primate mammals (PubMed:22051675). May be involved in the optokinetic visual tracking response (PubMed:26392540). May also play a role in regulating retinal hyaloid vessel growth and regression (PubMed:30936473)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Melanopsin containing retinal ganglion cell axons project to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment or the pupillary light reflex, [RefSeq, PubMed]; Melanopsin is not essential for the circadian clock to receive photic input, but it contributes significantly to the magnitude of photic responses, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A4QPG3;B2C712", "ec_number_list": "", "go_molecular_function": "GO:0005502 11-cis retinal binding;GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:1990384 hyaloid vascular plexus regression;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0045938 positive regulation of circadian sleep/wake cycle, sleep", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9QXZ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1J0-1", "uniprot_id": "NSDHL_MOUSE", "mass": 40686.0, "length": 362, "protein_name": "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "gene_name": "Nsdhl", "organism": "Mouse", "refseq_name": "sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "refseq_ac": "NP_035071", "gene_names_uniprotkb": "Nsdhl", "gene_names_refseq": "Bpa; H105E3; Nsdhl; Str; XAP104", "protein_names_uniprotkb": "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; 1.1.1.170", "protein_names_refseq": "NAD(P)-dependent steroid dehydrogenase-like protein; bare patches; sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; striated", "tax_id": 10090, "disease": "X-linked chondrodysplasia punctata 1 (Disease Ontology:DOID:0060292); CHILD syndrome (Disease Ontology:DOID:0111822); CK syndrome (Disease Ontology:DOID:0111898); Bloch-Sulzberger syndrome (Disease Ontology:DOID:12305); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:18194); (R-MMU-6807047); (R-MMU-6807062)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10369263;10854409;14506130;14567972;16075062;23125191;28011936;30582412;31219806;31985358;33649536;34203471;34428180", "class_list": "", "function": "Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis (PubMed:10369263, PubMed:14567972). Plays a role in the regulation of the endocytic trafficking of EGFR (PubMed:23125191)., [UniProtKB, PubMed, PubMed, PubMed]; Statins repress hedgehog signaling in medulloblastoma with no bone toxicities., [RefSeq, PubMed]; Suppression of NSDHL attenuates adipogenesis with a downregulation of LXR-SREBP1 pathway in 3T3-L1 cells., [RefSeq, PubMed]; The findings indicate that MSMO1 and NSDHL are novel modulators of adipogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55109", "ec_number_list": "1.1.1.170", "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0000252 3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity;GO:0102175 3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0001942 hair follicle development;GO:0060716 labyrinthine layer blood vessel development;GO:0007224 smoothened signaling pathway;GO:0033489 cholesterol biosynthetic process via desmosterol", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9R1J0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUK7-1", "uniprot_id": "OPN3_MOUSE", "mass": 44947.0, "length": 400, "protein_name": "Opsin-3", "gene_name": "Opn3", "organism": "Mouse", "refseq_name": "opsin-3", "refseq_ac": "NP_034228", "gene_names_uniprotkb": "Opn3; Ecpn", "gene_names_refseq": "ERO; Ecpn; Opn3", "protein_names_uniprotkb": "Opsin-3; Encephalopsin; Panopsin", "protein_names_refseq": "opsin (encephalopsin); opsin-3; panopsin", "tax_id": 10090, "disease": "", "pathway": " (mmu:13603); (R-MMU-418594); (R-MMU-419771)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10234000;12242008;14517541;25428506;30284927;32040503;37287644;39951488", "class_list": "", "function": "Encephalopsin (OPN3) is required for normal refractive development and the GO/GROW response to induced myopia. Publication Status: Online-Only, [RefSeq, PubMed]; G protein-coupled photoreceptor that selectively activates G(i/o) proteins in response to light, thereby decreasing intracellular cAMP levels (PubMed:30284927). Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade. Mediates blue light-induced pigmentation in melanocytes by activating calcium/CAMK2 signaling, followed by phosphorylation of CREB, p38, ERK and MITF (By similarity). Required for TYR and DCT blue light-induced complex formation in melanocytes. Involved in keratinocyte differentiation in response to blue-light. Plays a role in melanocyte survival through regulation of intracellular calcium levels and subsequent BCL2/RAF1 signaling. Additionally, regulates apoptosis via cytochrome c release and subsequent activation of the caspase cascade. Responsible for ultraviolet A (UVA)-induced keratinocytes supranuclear melanin cap formation via activating calcium/CAMK2, CREB, and Akt signal transduction, and ultimately increasing DYNC1I1 and DCTN1 expression levels, thereby playing a role in the skin response to UV radiation. Required for the UVA-mediated induction of calcium and MAPK signaling resulting in the expression of MMP1, MMP2, MMP3, MMP9 and TIMP1 in dermal fibroblasts (By similarity). Also plays a role in light-mediated glucose uptake, mitochondrial respiration and fatty acid metabolism in brown adipocyte tissues (PubMed:32040503). May be involved in photorelaxation of airway smooth muscle cells, via blue light-dependent GPCR signaling pathways (PubMed:30284927). Also inhibits melanogenesis in melanocytes by specifically inhibiting MC1R-evoked cAMP signaling in a constitutive, light-independent manner (By similarity). In the paraventricular nucleus of the hypothalamus, inhibits MC4R-mediated cAMP signaling and activates KCNJ13 channel opening in a constitutive manner, thereby promoting food intake and modulating spontaneous firing of neurons (PubMed:39951488)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Studies clearly show that activation of sensory transduction by unliganded opsin, and not the accumulation of retinyl esters, causes light-independent retinal degeneration in Leber congenital amaurosis, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0X3", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005503 all-trans retinal binding;GO:0005502 11-cis retinal binding;GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:1904000 positive regulation of eating behavior;GO:0048022 negative regulation of melanin biosynthetic process;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9WUK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVD5-1", "uniprot_id": "ORNT1_MOUSE", "mass": 32823.0, "length": 301, "protein_name": "Mitochondrial ornithine transporter 1", "gene_name": "Slc25a15", "organism": "Mouse", "refseq_name": "mitochondrial ornithine transporter 1", "refseq_ac": "NP_851842", "gene_names_uniprotkb": "Slc25a15; Ornt1", "gene_names_refseq": "D630044L02Rik; Ornt1; Slc25a15", "protein_names_uniprotkb": "Mitochondrial ornithine transporter 1; Solute carrier family 25 member 15", "protein_names_refseq": "mitochondrial ornithine transporter 1; ornithine transporter, mitochondrial 1; solute carrier family 25 member 15", "tax_id": 10090, "disease": "ornithine translocase deficiency (Disease Ontology:DOID:0050720); amino acid metabolic disorder (Disease Ontology:DOID:9252); citrullinemia (Disease Ontology:DOID:9273)", "pathway": " (mmu:18408); (R-MMU-70635)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10369256;19287344;19372376;23806337;25428506;31219806;34428180;37453647", "class_list": "", "function": "Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~55%., [RefSeq, PubMed]; Mitochondrial ornithine-citrulline antiporter. Catalyzes the exchange between cytosolic ornithine and mitochondrial citrulline plus an H(+), the proton compensates the positive charge of ornithine thus leading to an electroneutral transport. Plays a crucial role in the urea cycle, by connecting the cytosolic and the intramitochondrial reactions of the urea cycle. Lysine and arginine are also transported by the antiport mechanism (By similarity). In addition, catalyzes an electroneutral exchange of ornithine or lysine for H(+), a reaction driven by the pH gradient across the inner membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000064 L-ornithine transmembrane transporter activity;GO:0015297 antiporter activity;GO:0015189 L-lysine transmembrane transporter activity;GO:0061459 L-arginine transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:1903401 L-lysine transmembrane transport;GO:1990575 mitochondrial L-ornithine transmembrane transport;GO:1903826 L-arginine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WVD5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08850-1", "uniprot_id": "RGS5_MOUSE", "mass": 21086.0, "length": 181, "protein_name": "Regulator of G protein signaling 5", "gene_name": "Rgs5", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 5 isoform 1", "refseq_ac": "NP_033089", "gene_names_uniprotkb": "Rgs5", "gene_names_refseq": "1110070A02Rik; Rgs5", "protein_names_uniprotkb": "Regulator of G protein signaling 5; RGS5", "protein_names_refseq": "regulator of G-protein signaling 5 isoform 1", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825)", "pathway": " (mmu:19737); (R-MMU-416476); (R-MMU-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12514120;21750661;34428180;37674228;9079700", "class_list": "", "function": "Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha., [UniProtKB]; RGS5 augments astrocyte activation and facilitates neuroinflammation via TNF signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Rgs5 represents a potential regulator of PDGF and EDG receptor signaling during vascular maturation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543B1;Q9D0Z2", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O08850-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUK4-1", "uniprot_id": "RFC2_MOUSE", "mass": 38725.0, "length": 349, "protein_name": "Replication factor C subunit 2", "gene_name": "Rfc2", "organism": "Mouse", "refseq_name": "replication factor C subunit 2", "refseq_ac": "NP_064406", "gene_names_uniprotkb": "Rfc2", "gene_names_refseq": "2610008M13Rik; 40kDa; Recc2; Rfc2", "protein_names_uniprotkb": "Replication factor C subunit 2; A1 40 kDa subunit; Activator 1 40 kDa subunit; Activator 1 subunit 2; RF-C 40 kDa subunit; RFC40; Replication factor C 40 kDa subunit", "protein_names_refseq": "A1 40 kDa subunit; RF-C 40 kDa subunit; RFC40; activator 1 40 kDa subunit; activator 1 subunit 2; replication factor C 40 kDa subunit; replication factor C subunit 2; replication factor C, 40 kDa", "tax_id": 10090, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (mmu:19718); (R-MMU-110312); (R-MMU-110314); (R-MMU-110320); (R-MMU-174411); (R-MMU-176187); (R-MMU-5651801); (R-MMU-5655862); (R-MMU-5656121); (R-MMU-5656169); (R-MMU-5685938); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693607); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6804756); (R-MMU-69091); (R-MMU-69473)", "pathway_count": 21, "publication_count": 9, "publication_id_list": "11003705;19224205;20173027;21750661;21952136;25428507;25605945;34428180;35820727", "class_list": "", "function": "Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (By similarity). This subunit binds ATP (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0016887 ATP hydrolysis activity;GO:0003689 DNA clamp loader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031390 Ctf18 RFC-like complex;GO:0005663 DNA replication factor C complex;GO:0031389 Rad17 RFC-like complex", "go_biological_process": "GO:0006281 DNA repair;GO:1900264 positive regulation of DNA-directed DNA polymerase activity;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WUK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97393-1", "uniprot_id": "RHG05_MOUSE", "mass": 172472.0, "length": 1503, "protein_name": "Rho GTPase-activating protein 5", "gene_name": "Arhgap5", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 5 isoform 1", "refseq_ac": "NP_033836", "gene_names_uniprotkb": "Arhgap5; Rhogap5", "gene_names_refseq": "Arhgap5; p190-B; p190B", "protein_names_uniprotkb": "Rho GTPase-activating protein 5; Rho-type GTPase-activating protein 5; p190-B", "protein_names_refseq": "rho GTPase-activating protein 5 isoform 1; rho GTPase-activating protein 5; rho-type GTPase-activating protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:11855); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013406); (R-MMU-9013408); (R-MMU-9013409); (R-MMU-9013423); (R-MMU-9035034); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 14, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12015964;12637587;19144319;21183079;21750661;23563238;25428506;28176763;30084848;9838117", "class_list": "", "function": "GTPase-activating protein for Rho family members., [UniProtKB, UniProtKB]; Loss of p190-B expression is associated with defective hematopoiesis., [RefSeq, PubMed]; Mice lacking the Rho-inhibitory protein, p190-B RhoGAP, are 30% reduced in size and exhibit developmental defects strikingly similar to those seen in mice lacking the CREB transcription factor., [RefSeq, PubMed]; Results suggest that p190-B regulates ductal morphogenesis, at least in part, by modulating the IGF signaling axis, [RefSeq, PubMed]; Study suggests a link between p190-B-RhoGAP and non-canonical TGF-beta signaling in hematopoietic stem and progenitor cell differentiation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9PYT0;E9Q0L8", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0042169 SH2 domain binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0007266 Rho protein signal transduction;GO:0030879 mammary gland development;GO:0002053 positive regulation of mesenchymal cell proliferation;GO:0008361 regulation of cell size", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P97393-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K342-1", "uniprot_id": "RASF9_MOUSE", "mass": 49582.0, "length": 435, "protein_name": "Ras association domain-containing protein 9", "gene_name": "Rassf9", "organism": "Mouse", "refseq_name": "ras association domain-containing protein 9", "refseq_ac": "NP_666352", "gene_names_uniprotkb": "Rassf9; Pamci; Pcip1", "gene_names_refseq": "Pamci; Rassf9", "protein_names_uniprotkb": "Ras association domain-containing protein 9; P-CIP1; PAM COOH-terminal interactor protein 1; Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor", "protein_names_refseq": "P-CIP1; PAM COOH-terminal interactor protein 1; peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor; ras association domain-containing protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:237504)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21445300;21750661;34428180", "class_list": "", "function": "In RASSF9-/- keratinocytes there was a drastic down-modulation of terminal differentiation markers, which could be rescued by infection with a recombinant adenovirus, Adv/HA-RASSF9 Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in regulating vesicuar trafficking in cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZV4", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0012510 trans-Golgi network transport vesicle membrane;GO:0005768 endosome;GO:0005829 cytosol;GO:0055037 recycling endosome", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K342-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63321-1", "uniprot_id": "RALA_MOUSE", "mass": 23553.0, "length": 206, "protein_name": "Ras-related protein Ral-A", "gene_name": "Rala", "organism": "Mouse", "refseq_name": "ras-related protein Ral-A", "refseq_ac": "NP_062364", "gene_names_uniprotkb": "Rala; Ral-a; Ral", "gene_names_refseq": "3010001O15Rik; Rala; Ral; Rasl1", "protein_names_uniprotkb": "Ras-related protein Ral-A; 3.6.5.2", "protein_names_refseq": "RAS-like, family 1; ral-A protein; ras-related protein Ral-A; v-ral simian leukemia viral oncogene A (ras related); v-ral simian leukemia viral oncogene homolog A (ras related)", "tax_id": 10090, "disease": "pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498)", "pathway": " (mmu:56044)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11025226;20005108;21750661;24222664;30059200;37511290;38286821;8570186", "class_list": "", "function": "Impaired Insulin Signaling Mediated by the Small GTPase Rac1 in Skeletal Muscle of the Leptin-Deficient Obese Mouse. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (By similarity). The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (By similarity). During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1 (By similarity)., [UniProtKB, PubMed, UniProtKB]; Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P05810", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.4.-;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0043209 myelin sheath", "go_biological_process": "GO:0051665 membrane raft localization;GO:0031623 receptor internalization;GO:0032956 regulation of actin cytoskeleton organization;GO:0051301 cell division;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P63321-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C570-1", "uniprot_id": "RAE1L_MOUSE", "mass": 40965.0, "length": 368, "protein_name": "mRNA export factor", "gene_name": "Rae1", "organism": "Mouse", "refseq_name": "mRNA export factor", "refseq_ac": "NP_780321", "gene_names_uniprotkb": "Rae1; Mrnp41", "gene_names_refseq": "3230401I12Rik; D2Ertd342e; MNRP41; MNRP; Rae1", "protein_names_uniprotkb": "mRNA export factor; Rae1 protein homolog; mRNA-associated protein mrnp 41", "protein_names_refseq": "RAE1 RNA export 1 homolog; mRNA export factor; mRNA-associated protein mrnp 41; rae1 protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66679); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885)", "pathway_count": 18, "publication_count": 15, "publication_id_list": "10209021;15629720;21750661;25428506;25605945;28135057;29187734;30084848;30683868;31219806;34063622;34428180;36210013;37828378;38417691", "class_list": "", "function": "Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton., [UniProtKB, UniProtKB]; RAE1 and NUP98 participate inBMAL1 shuttling and promote the degradation and activity of BMAL1 and CLOCK. Publication Status: Online-Only, [RefSeq, PubMed]; RAE1 promotes gastric carcinogenesis and epithelial-mesenchymal transition., [RefSeq, PubMed]; Ribonucleic Acid Export 1 Is a Kinetochore-Associated Protein That Participates in Chromosome Alignment in Mouse Oocytes. Publication Status: Online-Only, [RefSeq, PubMed]; VSV M protein blocks mRNA export by disrupting Rae1 function, which can be reverted by induction of Rae1 expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKD4", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0051301 cell division;GO:0060236 regulation of mitotic spindle organization;GO:0006405 RNA export from nucleus;GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8C570-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMS9-1", "uniprot_id": "RASF2_MOUSE", "mass": 37973.0, "length": 326, "protein_name": "Ras association domain-containing protein 2", "gene_name": "Rassf2", "organism": "Mouse", "refseq_name": "ras association domain-containing protein 2", "refseq_ac": "NP_780654", "gene_names_uniprotkb": "Rassf2; Kiaa0168", "gene_names_refseq": "3830431H01Rik; 9030412M04Rik; Rassf2", "protein_names_uniprotkb": "Ras association domain-containing protein 2", "protein_names_refseq": "Ras association (RalGDS/AF-6) domain family 2; ras association domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:215653)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;22227519;26495903;31599954", "class_list": "", "function": "Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation (By similarity)., [UniProtKB]; These observations indicate that RASSF2 regulates osteoblast and osteoclast differentiation by inhibiting NF-kappaB signalling via association with IkappaB kinase (IKK) alpha and beta forms and suppression of IKK activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6A0B2", "ec_number_list": "", "go_molecular_function": "GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0045860 positive regulation of protein kinase activity;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BMS9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VE37-1", "uniprot_id": "RCC1_MOUSE", "mass": 44931.0, "length": 421, "protein_name": "Regulator of chromosome condensation", "gene_name": "Rcc1", "organism": "Mouse", "refseq_name": "regulator of chromosome condensation isoform 2", "refseq_ac": "NP_598639", "gene_names_uniprotkb": "Rcc1; Chc1", "gene_names_refseq": "4931417M11Rik; Chc1; Rcc1", "protein_names_uniprotkb": "Regulator of chromosome condensation; Chromosome condensation protein 1", "protein_names_refseq": "chromosome condensation protein 1; regulator of chromosome condensation isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:100088); (R-MMU-9615933)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "20668449;21750661;25428506;26495903;30084848", "class_list": "", "function": "Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDB6", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046982 protein heterodimerization activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0042393 histone binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle;GO:0000082 G1/S transition of mitotic cell cycle;GO:0007088 regulation of mitotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VE37-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKK0-1", "uniprot_id": "RCAN3_MOUSE", "mass": 27153.0, "length": 239, "protein_name": "Calcipressin-3", "gene_name": "Rcan3", "organism": "Mouse", "refseq_name": "calcipressin-3 isoform a", "refseq_ac": "NP_075356", "gene_names_uniprotkb": "Rcan3; Dscr1l2", "gene_names_refseq": "Csp3; Dscr1l2; Rcan3", "protein_names_uniprotkb": "Calcipressin-3; Down syndrome candidate region 1-like protein 2; MCIP3; Myocyte-enriched calcineurin-interacting protein 3; Regulator of calcineurin 3", "protein_names_refseq": "Down syndrome critical region gene 1-like 2; MCIP3; calcipressin-3 isoform a; calcipressin-3; down syndrome candidate region 1-like protein 2; myocyte-enriched calcineurin-interacting protein 3", "tax_id": 10090, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (mmu:53902)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11080588;17767500;21750661;25783055;35640493", "class_list": "", "function": "Found that RCAN1/3 interact with RAF kinases and CN in a non-exclusive manner. Our data suggests that the balance of RCAN interactions with CN and/or RAF kinases may influence T cell positive selection, [RefSeq, PubMed]; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The PxIxIT motif of the RCAN3 inhibits angiogenesis and tumor progression in Triple Negative breast cancer in immunocompetent mice., [RefSeq, PubMed]; The adult mice, RCAN3 was mainly expressed in the neuropil throughout the brain., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2I5;Q9CX87", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0019902 phosphatase binding;GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity;GO:0031013 troponin I binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JKK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPD6-1", "uniprot_id": "RAVR2_MOUSE", "mass": 72031.0, "length": 673, "protein_name": "Ribonucleoprotein PTB-binding 2", "gene_name": "Raver2", "organism": "Mouse", "refseq_name": "ribonucleoprotein PTB-binding 2", "refseq_ac": "NP_898845", "gene_names_uniprotkb": "Raver2; Kiaa1579", "gene_names_refseq": "A430091O22Rik; Raver2", "protein_names_uniprotkb": "Ribonucleoprotein PTB-binding 2; Protein raver-2", "protein_names_refseq": "protein raver-2; ribonucleoprotein PTB-binding 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:242570)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16051233;19962980;21750661;30084848", "class_list": "", "function": "May bind single-stranded nucleic acids., [UniProtKB]; Raver2 was identified as a novel member of the hnRNP family, it interacts with PTB/hnRNPI., [RefSeq, PubMed]; The conserved mode of polypyrimidine tract-binding protein binding suggests that Raver2, like Raver1, may function as a modulator of PTB activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ASP1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TPD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHP8-1", "uniprot_id": "RB40B_MOUSE", "mass": 31063.0, "length": 278, "protein_name": "Ras-related protein Rab-40B", "gene_name": "Rab40b", "organism": "Mouse", "refseq_name": "ras-related protein Rab-40B isoform 2", "refseq_ac": "NP_631886", "gene_names_uniprotkb": "Rab40b", "gene_names_refseq": "Rab40b; SEC4L; rar", "protein_names_uniprotkb": "Ras-related protein Rab-40B; 3.6.5.2; SOCS box-containing protein RAR", "protein_names_refseq": "RAR SOCS box containing protein; SOCS box-containing protein RAR; ras-related protein Rab-40B isoform 2; ras-related protein Rab-40B", "tax_id": 10090, "disease": "", "pathway": " (mmu:217371); (R-MMU-8873719)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;25428506;27909076", "class_list": "", "function": "RAB40B small GTPase acts as substrate-recognition components of the ECS(RAB40B) E3 ubiquitin ligase complex which mediates the ubiquitination of target proteins. The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. As part of the ECS(RAB40B) complex, GTP-bound RAB40B promotes LIMA1/EPLIN ubiquitination and degradation, thereby regulating leading-edge actin dynamics during cell migration. As part of the ECS(RAB40B) complex, GTP-bound RAB40B also ubiquitinates RAP2A GTPase which promotes its localization to lamellipodia and activation to drive cell migration. The ECS(RAB40B) complex does not mediate canonical ubiquitin-dependent degradation of RAP2. RAB40B also binds TKS5/SH3PXD2A effector independently from ECS complex to promote invadopodia-mediated extracellular matrix degradation., [UniProtKB, UniProtKB]; This is the first study that identifies a new Rab40b-Tks5- and miR-204-dependent invadopodia transport pathway that regulates MMP2 and MMP9 secretion, and extracellular matrix remodeling during cancer progression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;2.5.1.60;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0003925 G protein activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005829 cytosol", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0035556 intracellular signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VHP8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQY2-1", "uniprot_id": "RAMAC_MOUSE", "mass": 14556.0, "length": 119, "protein_name": "RNA guanine-N7 methyltransferase activating subunit", "gene_name": "Ramac", "organism": "Mouse", "refseq_name": "RNA guanine-N7 methyltransferase activating subunit", "refseq_ac": "NP_080273", "gene_names_uniprotkb": "Ramac; Fam103a1; Rammet", "gene_names_refseq": "2410047I02Rik; 2610204K14Rik; Fam103a1; RAM; Ramac; Rammet", "protein_names_uniprotkb": "RNA guanine-N7 methyltransferase activating subunit; Protein FAM103A1; RAM; RNA guanine-7 methyltransferase activating subunit; RNMT-activating mRNA cap methylating subunit; RNMT-activating mRNA cap methyltransferase subunit; RNMT-activating mini protein", "protein_names_refseq": "RNA guanine-N7 methyltransferase activating subunit; RNMT actvating mRNA cap methylating subunit; RNMT-activating mRNA cap methylating subunit; RNMT-activating mRNA cap methyltransferase subunit; RNMT-activating mini protein; family with sequence similarity 103, member A1; protein FAM103A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67148)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25428506;26495903;31219806;34428180", "class_list": "", "function": "Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT. Regulates RNMT expression by a post-transcriptional stabilizing mechanism. Binds RNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TV69;Q9CWI1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008047 enzyme activator activity;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031533 mRNA capping enzyme complex;GO:0034708 methyltransferase complex;GO:0160130 mRNA cap methyltransferase RNMT:RAMAC complex", "go_biological_process": "GO:0006370 7-methylguanosine mRNA capping;GO:0106005 RNA 5'-cap (guanine-N7)-methylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CQY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0F6-1", "uniprot_id": "RFC5_MOUSE", "mass": 38096.0, "length": 339, "protein_name": "Replication factor C subunit 5", "gene_name": "Rfc5", "organism": "Mouse", "refseq_name": "replication factor C subunit 5", "refseq_ac": "NP_082404", "gene_names_uniprotkb": "Rfc5", "gene_names_refseq": "2610020K06Rik; 2610209F07Rik; 36.5kDa; 36kDa; Recc5; Rfc5", "protein_names_uniprotkb": "Replication factor C subunit 5; A1 36 kDa subunit; Activator 1 36 kDa subunit; Activator 1 subunit 5; RF-C 36 kDa subunit; RFC36; Replication factor C 36 kDa subunit", "protein_names_refseq": "A1 36 kDa subunit; RF-C 36 kDa subunit; RFC36; activator 1 36 kDa subunit; activator 1 subunit 5; replication factor C 36 kDa subunit; replication factor C 5; replication factor C subunit 5; replication factor C, 36 kDa", "tax_id": 10090, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (mmu:72151); (R-MMU-110312); (R-MMU-110314); (R-MMU-110320); (R-MMU-174411); (R-MMU-176187); (R-MMU-5651801); (R-MMU-5655862); (R-MMU-5656121); (R-MMU-5656169); (R-MMU-5685938); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693607); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6804756); (R-MMU-69091); (R-MMU-69473)", "pathway_count": 21, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0016887 ATP hydrolysis activity;GO:0003689 DNA clamp loader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031390 Ctf18 RFC-like complex;GO:0005663 DNA replication factor C complex;GO:0031389 Rad17 RFC-like complex", "go_biological_process": "GO:0006281 DNA repair;GO:1900264 positive regulation of DNA-directed DNA polymerase activity;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D0F6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R527-1", "uniprot_id": "RHOQ_MOUSE", "mass": 22645.0, "length": 205, "protein_name": "Rho-related GTP-binding protein RhoQ", "gene_name": "Rhoq", "organism": "Mouse", "refseq_name": "rho-related GTP-binding protein RhoQ", "refseq_ac": "NP_663466", "gene_names_uniprotkb": "Rhoq; Arhq; Tc10", "gene_names_refseq": "Arhq; Rhoq; TC10A; Tc10", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoQ; 3.6.5.2; Ras-like protein TC10", "protein_names_refseq": "ras homolog gene family, member Q; ras-like protein TC10; ras-related GTP-binding protein TC10; rho-related GTP-binding protein RhoQ; small GTPase Tc10", "tax_id": 10090, "disease": "", "pathway": " (mmu:104215); (R-MMU-5627083); (R-MMU-9013406)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10490598;12456725;12773384;21750661;28747344;29891904;32652719;33156548;37828378", "class_list": "", "function": "Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia (By similarity)., [UniProtKB]; Reelin activates the small GTPase TC10 and VAMP7 to promote neurite outgrowth and regeneration of dorsal root ganglia (DRG) neurons., [RefSeq, PubMed]; TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron-autonomous manner., [RefSeq, PubMed]; The authors show that Arhgef7 interacts with the GTPase TC10 that is closely related to Cdc42. Expression of active TC10 can restore the ability to extend axons in Arhgef7-deficient neurons Publication Status: Online-Only, [RefSeq, PubMed]; This study defines TC10 as an immunomodulatory molecule playing a role in physiological B cell responses, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNC0;Q80VH4", "ec_number_list": "3.6.5.-;2.7.11.1;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;5.6.1.6;3.6.5.5;3.6.4.-;3.6.1.-;3.6.1.15;3.6.-.-;1.16.1.-;2.3.2.26", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0005522 profilin binding;GO:0032427 GBD domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0032869 cellular response to insulin stimulus;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R527-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99J62-1", "uniprot_id": "RFC4_MOUSE", "mass": 39867.0, "length": 364, "protein_name": "Replication factor C subunit 4", "gene_name": "Rfc4", "organism": "Mouse", "refseq_name": "replication factor C subunit 4", "refseq_ac": "NP_663455", "gene_names_uniprotkb": "Rfc4", "gene_names_refseq": "A1; RFC37; Rfc4", "protein_names_uniprotkb": "Replication factor C subunit 4; Activator 1 subunit 4", "protein_names_refseq": "activator 1 subunit 4; replication factor C subunit 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:106344); (R-MMU-110312); (R-MMU-110314); (R-MMU-110320); (R-MMU-174411); (R-MMU-176187); (R-MMU-5651801); (R-MMU-5655862); (R-MMU-5656121); (R-MMU-5656169); (R-MMU-5685938); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693607); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6804756); (R-MMU-69091); (R-MMU-69473)", "pathway_count": 21, "publication_count": 4, "publication_id_list": "21750661;30059200;31219806;32640224", "class_list": "", "function": "Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. The RFC4 subunit probably functions as a scaffold on which the other complex components can assemble., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0016887 ATP hydrolysis activity;GO:0003689 DNA clamp loader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031390 Ctf18 RFC-like complex;GO:0031391 Elg1 RFC-like complex;GO:0005663 DNA replication factor C complex", "go_biological_process": "GO:0006281 DNA repair;GO:1900264 positive regulation of DNA-directed DNA polymerase activity;GO:0006261 DNA-templated DNA replication;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99J62-1", "record_type": "protein" } ]