[
    {
        "uniprot_canonical_ac": "Q03403-1",
        "uniprot_id": "TFF2_HUMAN",
        "mass": 14284.0,
        "length": 129,
        "protein_name": "Trefoil factor 2",
        "gene_name": "TFF2",
        "organism": "Human",
        "refseq_name": "trefoil factor 2 precursor",
        "refseq_ac": "NP_005414",
        "gene_names_uniprotkb": "TFF2; SML1",
        "gene_names_refseq": "SML1; SP; TFF2",
        "protein_names_uniprotkb": "Trefoil factor 2; SP; Spasmolysin; Spasmolytic polypeptide",
        "protein_names_refseq": "spasmolysin; spasmolytic polypeptide; spasmolytic protein 1; trefoil factor 2 precursor",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283)",
        "pathway": " (hsa:7032)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "10950923;1505966;15489334;2303034;31817054;32122390;32814053;32897966;33515301;34242119;34662329;34944474;37074911;7566098;7961636;8405856;9070946",
        "class_list": "",
        "function": "Circulating trefoil factors in relation to lung cancer, age and lung function: a cross-sectional study in patients referred for suspected lung cancer., [RefSeq, PubMed]; Diet Impact on Obesity beyond Calories and Trefoil Factor Family 2 (TFF2) as an Illustration: Metabolic Implications and Potential Applications. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity)., [UniProtKB]; Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]., [RefSeq]; Parasitic helminth infections in humans modulate Trefoil Factor levels in a manner dependent on the species of parasite and age of the host. Publication Status: Online-Only, [RefSeq, PubMed]; Pyloric, pseudopyloric, and spasmolytic polypeptide-expressing metaplasias in autoimmune gastritis: a case series of 22 Japanese patients., [RefSeq, PubMed]; Trefoil Factor 2 (TFF2) as a Surrogate Marker for Endocervical Gastric-type Carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 9507,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q15854",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031723 CXCR4 chemokine receptor binding",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0060455 negative regulation of gastric acid secretion;GO:0070098 chemokine-mediated signaling pathway;GO:0030277 maintenance of gastrointestinal epithelium",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q03403-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q06250-1",
        "uniprot_id": "WIT1_HUMAN",
        "mass": 10039.0,
        "length": 92,
        "protein_name": "Putative Wilms tumor upstream neighbor 1 gene protein",
        "gene_name": "WT1-AS",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "WT1-AS; WIT1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative Wilms tumor upstream neighbor 1 gene protein; WIT-1; Wilms tumor-associated antisense RNA",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "2173145;8406502",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4KMY0;Q96A27",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q06250-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q99618-1",
        "uniprot_id": "CDCA3_HUMAN",
        "mass": 28998.0,
        "length": 268,
        "protein_name": "Cell division cycle-associated protein 3",
        "gene_name": "CDCA3",
        "organism": "Human",
        "refseq_name": "cell division cycle-associated protein 3 isoform 3",
        "refseq_ac": "NP_001284532",
        "gene_names_uniprotkb": "CDCA3; C8; GRCC8; TOME1",
        "gene_names_refseq": "CDCA3; GRCC8; TOME-1; TOME1",
        "protein_names_uniprotkb": "Cell division cycle-associated protein 3; Gene-rich cluster protein C8; TOME-1; Trigger of mitotic entry protein 1",
        "protein_names_refseq": "cell division cycle-associated protein 3 isoform 3; cell division cycle-associated protein 3; gene-rich cluster protein C8; trigger of mitotic entry protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:83461)",
        "pathway_count": 1,
        "publication_count": 49,
        "publication_id_list": "11237011;12188893;15733861;17081983;17525332;18220336;18578522;18669648;18691976;19413330;19651622;19664994;19690332;20058876;20068231;22839099;23186163;23219899;24366607;26154972;26992070;27920218;28832583;29242379;29485866;29493099;30315122;31530632;31844290;32157095;32488085;32502341;32897882;32938616;33968037;33981976;34171305;34932366;35051231;35251023;35561310;35580925;36071275;36081320;36087462;36241641;37625824;39894887;9074930",
        "class_list": "",
        "function": "A repressor element (cell-cycle-dependent element/cell cycle gene homology region) in the vicinity of the transcription start site, and mutations within this element diminished the cell-cycle-dependent transcriptional regulation of Tome-1, [RefSeq, PubMed]; CDCA3 exhibits a role in promoting the progression of ovarian cancer., [RefSeq, PubMed]; F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity)., [UniProtKB]; HoxB3 promote prostate cancer progression by upregulating CDCA3 expression., [RefSeq, PubMed]; Identification of circ_0038632 as a Promoter of Breast Cancer through miR-520a-3p-Dependent Modulation of CDCA3., [RefSeq, PubMed]; MYBL2 promotes proliferation and metastasis of bladder cancer through transactivation of CDCA3., [RefSeq, PubMed]; MiRNA-144-5p down-modulates CDCA3 to regulate proliferation and apoptosis of lung adenocarcinoma cells., [RefSeq, PubMed]; Overexpression of CDCA3 occurs frequently during oral carcinogenesis. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 19,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5V6;D3DUS6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005912 adherens junction",
        "go_biological_process": "GO:0051301 cell division;GO:0016567 protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 5.2,
        "record_id": "Q99618-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y224-1",
        "uniprot_id": "RTRAF_HUMAN",
        "mass": 28068.0,
        "length": 244,
        "protein_name": "tRNA-splicing ligase complex subunit RTRAF",
        "gene_name": "RTRAF",
        "organism": "Human",
        "refseq_name": "tRNA-splicing ligase complex subunit RTRAF",
        "refseq_ac": "NP_057123",
        "gene_names_uniprotkb": "RTRAF; C14orf166; CGI-99",
        "gene_names_refseq": "C14orf166; CGI-99; CGI99; CLE7; CLE; LCRP369; RLLM1; RTRAF; hCLE1; hCLE",
        "protein_names_uniprotkb": "tRNA-splicing ligase complex subunit RTRAF; CLE7 homolog; CLE; RNA transcription, translation and transport factor protein; hCLE",
        "protein_names_refseq": "CLE7 homolog; RLL motif containing 1; RNA transcription, translation and transport factor protein; UPF0568 protein C14orf166; tRNA-splicing ligase complex subunit RTRAF",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51637);  (R-HSA-6784531)",
        "pathway_count": 2,
        "publication_count": 120,
        "publication_id_list": "10444065;11237011;11455963;11507205;11727826;11871657;12138183;12526808;12711671;12729736;15109492;15147888;15317868;16361254;16710424;16950395;17204286;17224653;18226598;18809514;18984158;18991276;19608861;20068231;21209280;21311021;21450806;21559454;21593607;21740066;21823664;21900157;22944664;23481700;23646949;24608264;2470644;24715725;24870230;25418920;25502872;25576301;25640237;25645385;25849199;25892735;26768311;26864902;26929215;26992070;27543614;27600516;27920218;28040436;28063628;28228285;28467828;28649982;28832583;28834231;28855257;28904123;29242379;29393594;29508533;29557506;29632046;29632711;29786170;30315122;30429286;30484775;30524438;30779550;31217245;31844290;32157095;32265295;32350084;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33214551;33392160;33592498;33717175;33968037;33981976;34019948;34078123;34087483;34171305;34229054;34357683;34509645;34854379;34932366;35051231;35154160;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37217939;37265372;37938771;38665916;39990658;6930639;7759547;7828588;9512417;9660920",
        "class_list": "",
        "function": "(Microbial infection) In case of infection by influenza virus A (IVA), is involved in viral replication (PubMed:21900157)., [UniProtKB, PubMed]; A novel protein CGI-99 is isolated, which may be involved in the functional regulation of human ninein in the centrosome structure and may also be important in brain development and tumorigenesis., [RefSeq, PubMed]; Accessory subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester (PubMed:21311021, PubMed:24870230). RNA-binding protein involved in modulation of mRNA transcription by Polymerase II (PubMed:16950395). Could also play a role in RNA transport (PubMed:24608264)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; An in silico prediction of interaction models of influenza A virus PA and human C14orf166 protein from yeast-two-hybrid screening data., [RefSeq, PubMed]; Molecular architecture of the human tRNA ligase complex. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0000993 RNA polymerase II complex binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006469 negative regulation of protein kinase activity;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0050658 RNA transport",
        "synthesized_glycan_count": 0,
        "hit_score": 12.3,
        "record_id": "Q9Y224-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q4W4Y0-1",
        "uniprot_id": "DRIP1_HUMAN",
        "mass": 36306.0,
        "length": 310,
        "protein_name": "Dopamine receptor-interacting protein 1",
        "gene_name": "DORIP1",
        "organism": "Human",
        "refseq_name": "dopamine receptor-interacting protein 1",
        "refseq_ac": "NP_001017923",
        "gene_names_uniprotkb": "DORIP1; C14orf28; DRIP1",
        "gene_names_refseq": "C14orf28; DORIP1; DRIP-1; DRIP1; c14_5270",
        "protein_names_uniprotkb": "Dopamine receptor-interacting protein 1",
        "protein_names_refseq": "dopamine receptor-interacting protein 1; uncharacterized protein C14orf28",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:122525)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11237011;20874815;23481700;32983136;33592498;36284347",
        "class_list": "",
        "function": "Could be a regulator of the dopamine receptor signaling pathway., [UniProtKB, UniProtKB]; Our data suggest: (i) C14ORF28, GNB2L1, MLLT3, DRD2 and DARPP-32 are important in the pathogenesis of schizophrenia and bipolar disorder, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "GO:0098989 NMDA selective glutamate receptor signaling pathway;GO:0007212 G protein-coupled dopamine receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q4W4Y0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N1G2-1",
        "uniprot_id": "CMTR1_HUMAN",
        "mass": 95321.0,
        "length": 835,
        "protein_name": "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1",
        "gene_name": "CMTR1",
        "organism": "Human",
        "refseq_name": "cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1",
        "refseq_ac": "NP_055865",
        "gene_names_uniprotkb": "CMTR1; FTSJD2; KIAA0082; MTR1",
        "gene_names_refseq": "CMTR1; FTSJD2; KIAA0082; MTr1; hMTr1",
        "protein_names_uniprotkb": "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; 2.1.1.57; Cap methyltransferase 1; Cap1 2'O-ribose methyltransferase 1; FtsJ methyltransferase domain-containing protein 2; ISG95; Interferon-stimulated gene 95 kDa protein; MTr1; hMTr1",
        "protein_names_refseq": "FtsJ methyltransferase domain containing 2; ISG95; S-adenosyl-L-methionine-dependent methyltransferase FTSJD2; cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; cap1 2'O-ribose methyltransferase 1; ftsJ methyltransferase domain-containing protein 2; interferon-stimulated gene 95 kDa protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23070)",
        "pathway_count": 1,
        "publication_count": 96,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;12743294;12743306;17081983;18083107;18533109;18669648;19413330;19608861;19651622;19664995;20068231;20713356;21310715;22424782;22645359;23186163;23481700;24275569;24366607;24397554;24402442;25418920;25576301;25645385;25892735;26154972;26811146;26992070;27600516;27846572;27920218;28063628;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29632711;29769354;30315122;30320910;30397098;30429286;30620550;30833945;31154438;31217245;31222486;31530632;31844290;31848261;32157095;32161166;32357974;32387766;32404510;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33633747;33691108;33717175;33912179;33936100;33968037;34019948;34087483;34171305;34211107;34405274;34509645;34932366;35051231;35580925;36010968;36241641;36284347;36581221;37024465;37938771;38923463;40596516",
        "class_list": "",
        "function": "CK2 phosphorylation of CMTR1 promotes RNA cap formation and influenza virus infection., [RefSeq, PubMed]; CMTR1 promotes colorectal cancer cell growth and immune evasion by transcriptionally regulating STAT3. Publication Status: Online-Only, [RefSeq, PubMed]; CMTr1 binds ATP-dependent RNA DHX15 helicase and that this interaction, mediated by the G-patch domain of CMTr1, has an advantageous effect on CMTr1 activity towards highly structured RNA substrates. Publication Status: Online-Only, [RefSeq, PubMed]; Crystal structures of the active CMTr1 catalytic domain in complex with a methyl group donor and a capped oligoribonucleotide are examined, thereby revealing the mechanism of specific recognition of capped RNA., [RefSeq, PubMed]; HMTr1 catalyzes specific methylation of the 2'-O-ribose of the first nucleotide of a capped RNA transcript., [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway., [UniProtKB, PubMed, PubMed, PubMed]; The data presented here are consistent with the important role played by hMTr1 in pre-mRNA synthesis., [RefSeq, PubMed]; The mRNA Cap 2'-O-Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes. Publication Status: Online-Only, [RefSeq, PubMed]; The results presented in this work indicate that ISG95 is part of the interferon response pathway and functions in the pre-mRNA processing events mediated by the C-terminal domain of the RNA polymerase II., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 15,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K949;Q14670;Q96FJ9",
        "ec_number_list": "2.1.1.57",
        "go_molecular_function": "GO:0004483 methyltransferase cap1 activity;GO:0003676 nucleic acid binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0032259 methylation;GO:0006370 7-methylguanosine mRNA capping;GO:0016556 mRNA modification",
        "synthesized_glycan_count": 0,
        "hit_score": 10.1,
        "record_id": "Q8N1G2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00421-1",
        "uniprot_id": "CCRL2_HUMAN",
        "mass": 39513.0,
        "length": 344,
        "protein_name": "C-C chemokine receptor-like 2",
        "gene_name": "CCRL2",
        "organism": "Human",
        "refseq_name": "C-C chemokine receptor-like 2 isoform 2",
        "refseq_ac": "NP_001124382",
        "gene_names_uniprotkb": "CCRL2; CCR11; CCR6; CKRX; CRAM; HCR",
        "gene_names_refseq": "ACKR5; CCRL2; CKRX; CRAM-A; CRAM-B; CRAM; HCR",
        "protein_names_uniprotkb": "C-C chemokine receptor-like 2; Chemokine receptor CCR11; Chemokine receptor X; Putative MCP-1 chemokine receptor",
        "protein_names_refseq": "C-C chemokine receptor-like 2 isoform 2; C-C chemokine receptor-like 2; atypical chemokine receptor 5; chemokine (C-C motif) receptor-like 2; chemokine receptor CCR11; chemokine receptor X; putative MCP-1 chemokine receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9034);  (R-HSA-380108)",
        "pathway_count": 2,
        "publication_count": 59,
        "publication_id_list": "10229797;10640743;10706668;10725696;10725697;10781587;11060282;11237011;11828366;12149255;12554737;12884299;15067078;15188357;16107333;1744577;18397265;1840701;18794339;1891716;20002784;2078213;2217207;2423119;25880248;29242379;29557506;2970963;29789417;3098319;32357974;3260265;32983136;33253374;33373444;33968037;35051231;35580925;36662882;7602097;7622448;7642634;7679328;7851893;7875320;8048929;8383238;8639485;8849694;9024663;9164944;9166430;9169459;9207005;9276730;9390561;9463416;9473515;9618518",
        "class_list": "",
        "function": "C-C Chemokine receptor-like 2 (CCRL2) acts as coreceptor for human immunodeficiency virus-2., [RefSeq, PubMed]; CCRL2 expression is up-regulated on synovial neutrophils of rheumatoid arthritis patients, [RefSeq, PubMed]; Genomics Links Inflammation With Neurocognitive Impairment in Children Living With Human Immunodeficiency Virus Type-1., [RefSeq, PubMed]; Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses., [UniProtKB]; Results identify chemerin as a natural nonsignaling protein ligand for both human and mouse CCRL2., [RefSeq, PubMed]; Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DKQ8;O75307;Q4VBB0;Q6IPX0;Q7KYQ9;Q96KP5;Q9UPG0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004950 chemokine receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0042379 chemokine receptor binding;GO:0048020 CCR chemokine receptor binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration",
        "synthesized_glycan_count": 0,
        "hit_score": 6.0,
        "record_id": "O00421-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60583-1",
        "uniprot_id": "CCNT2_HUMAN",
        "mass": 81029.0,
        "length": 730,
        "protein_name": "Cyclin-T2",
        "gene_name": "CCNT2",
        "organism": "Human",
        "refseq_name": "cyclin-T2 isoform a",
        "refseq_ac": "NP_001232",
        "gene_names_uniprotkb": "CCNT2",
        "gene_names_refseq": "CCNT2; CYCT2",
        "protein_names_uniprotkb": "Cyclin-T2; CycT2",
        "protein_names_refseq": "SDS-stable vimentin-bound DNA fragment HEF42VIM22; cyclin T2a; cyclin T2b; cyclin-T2 isoform a; subunit of positive elongation transcription factor b",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:905);  (R-HSA-112382);  (R-HSA-167152);  (R-HSA-167287);  (R-HSA-167290);  (R-HSA-2173796);  (R-HSA-674695);  (R-HSA-6796648);  (R-HSA-6807505);  (R-HSA-75955)",
        "pathway_count": 10,
        "publication_count": 153,
        "publication_id_list": "10022869;10022900;10199400;10199401;10364329;10866664;10984493;11007770;11013220;11237011;11274402;11313498;11313499;11350971;11424093;11427533;11713533;11856838;11859374;11884399;11971958;11988847;12037672;12150994;12414730;12446674;12574128;12676794;12917425;14657019;14701755;15100235;15150273;1535687;15489290;15563843;15781865;16239144;16278212;16308568;16319104;16331689;16901896;17234882;17289077;17322306;1739980;17438144;18079403;1829677;18452278;18568018;18669648;18691976;18767875;19369195;1939271;19413330;19651622;19664994;19664995;19667075;19690332;19883659;19914168;19952111;20068231;20159561;20457598;20595680;2125285;21406692;21509660;22012619;22137580;22231121;22252320;22275377;22441827;22988298;23166507;23186163;23538671;23932780;24097444;24270878;2449431;24554720;24662513;24997600;25429106;25561469;25576301;25675981;25712099;26375851;26659056;27920218;28832583;28834231;28904123;29242379;29393594;2944599;29557506;29632046;29789417;30192525;30833945;31154438;31844290;31848261;31936902;31957815;32157095;32161166;32265295;32357974;32387766;32488085;32897882;32938616;32983136;33141586;33392160;33912179;33968037;34509645;35051231;36010968;36241641;36284347;37938771;7660122;7660129;7660130;7715707;7853496;8253082;8339931;8370526;8628262;8668525;9009278;9063748;9153304;9188510;9407024;9450929;9489704;9499409;9705341;9832505",
        "class_list": "",
        "function": "(Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters., [UniProtKB, PubMed]; MiRNA-188-5p alleviates the progression of osteosarcoma via target degrading CCNT2., [RefSeq, PubMed]; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:15563843, PubMed:9499409). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KA48;D3DP73;D3DP74;O60582;Q29R66;Q53SR4;Q5I1Y0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0019901 protein kinase binding;GO:0070063 RNA polymerase binding;GO:0001223 transcription coactivator binding;GO:0097322 7SK snRNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0008024 cyclin/CDK positive transcription elongation factor complex;GO:0000307 cyclin-dependent protein kinase holoenzyme complex",
        "go_biological_process": "GO:0019085 early viral transcription;GO:0019086 late viral transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0006366 transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 15.4,
        "record_id": "O60583-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P09543-1",
        "uniprot_id": "CN37_HUMAN",
        "mass": 47579.0,
        "length": 421,
        "protein_name": "2',3'-cyclic-nucleotide 3'-phosphodiesterase",
        "gene_name": "CNP",
        "organism": "Human",
        "refseq_name": "2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform 2",
        "refseq_ac": "NP_001317145",
        "gene_names_uniprotkb": "CNP",
        "gene_names_refseq": "CN37; CNP1; CNP; HLD20",
        "protein_names_uniprotkb": "2',3'-cyclic-nucleotide 3'-phosphodiesterase; 3.1.4.37; CNPase; CNP",
        "protein_names_refseq": "2'',3''-cyclic nucleotide 3'' phosphodiesterase; 2', 3' cyclic nucleotide 3' phosphohydrolase; 2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform 2; CNPase",
        "tax_id": 9606,
        "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); hypomyelinating leukodystrophy 20 (Disease Ontology:DOID:0112153); mucopolysaccharidosis VI (Disease Ontology:DOID:12800); carotid stenosis (Disease Ontology:DOID:13001); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); multiple sclerosis (Disease Ontology:DOID:2377); schizophrenia (Disease Ontology:DOID:5419)",
        "pathway": " (hsa:1267)",
        "pathway_count": 1,
        "publication_count": 98,
        "publication_id_list": "11237011;12643545;1360194;1385234;15713463;16150497;17081065;18510355;19413330;19664994;20166139;22009320;22645359;23186163;23481700;24714562;24715725;25418920;25576301;25645385;26154972;26728094;26929215;26992070;27600516;27846572;27862975;27920218;28218747;2835044;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29769354;29786170;30315122;30379171;30410026;30429286;30484775;30833945;31090455;31154438;31217245;31222486;31617266;31844290;31848261;32128616;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33633747;33653372;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34330062;34725712;34932366;35051231;35154160;35251023;35318648;35580925;36010968;36284347;37938771;38117830;38167610;38665916;40914422;8065530;8392017;9268698",
        "class_list": "",
        "function": "2',3'-Cyclic-nucleotide 3'-phosphodiesterase contributes to epithelial-mesenchymal transition of lens epithelial cells through the notch signalling pathway, [RefSeq, PubMed]; Acts as an antiviral factor by suppressing the assembly of HIV-1 virions through direct interaction with GAG., [UniProtKB, PubMed]; CNP deficiency causes severe hypomyelinating leukodystrophy., [RefSeq, PubMed]; Catatonia-related executive dysfunction and brain atrophy of Cnp(-/-) mice fail to improve under PLX5622., [RefSeq, PubMed]; Circ-AFF2/miR-650/CNP axis promotes proliferation, inflammatory response, migration, and invasion of rheumatoid arthritis synovial fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]; Myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides. In the mitochondria, regulates the functioning of the mitochondrial permeability transition pore (mPTP), and thus is involved in the mechanisms of cell death, both apoptosis and necrosis. Acts as an antiviral factor by suppressing the assembly of SARS-CoV-2 virions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 7,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "3.1.4.37",
        "go_molecular_function": "GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity;GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005874 microtubule;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0009214 cyclic nucleotide catabolic process;GO:0007268 chemical synaptic transmission;GO:0021762 substantia nigra development",
        "synthesized_glycan_count": 0,
        "hit_score": 10.1,
        "record_id": "P09543-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P22674-1",
        "uniprot_id": "CCNO_HUMAN",
        "mass": 38096.0,
        "length": 350,
        "protein_name": "Cyclin-O",
        "gene_name": "CCNO",
        "organism": "Human",
        "refseq_name": "cyclin-O",
        "refseq_ac": "NP_066970",
        "gene_names_uniprotkb": "CCNO",
        "gene_names_refseq": "CCNO; CCNU; CILD29; UDG2",
        "protein_names_uniprotkb": "Cyclin-O",
        "protein_names_refseq": "cyclin U; cyclin domain containing; cyclin-O",
        "tax_id": 9606,
        "disease": "primary ciliary dyskinesia 29 (Disease Ontology:DOID:0110600)",
        "pathway": " (hsa:10309)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "16697536;18691976;19369195;19413330;2001396;23186163;24747639;26777464;28218747;28860486;29242379;30087414;32157095;32938616;33912179;34102041;34569065;35051231;39894887;8419333",
        "class_list": "",
        "function": "Bi-allelic mutations in MCIDAS and CCNO cause human infertility associated with abnormal gamete transport., [RefSeq, PubMed]; CCNO mutations have a role in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia, [RefSeq, PubMed]; Primary ciliary dyskinesia due to CCNO mutations-A genotype-phenotype correlation contribution., [RefSeq, PubMed]; Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking., [UniProtKB, PubMed, PubMed]; This gene encodes a member of the cyclin protein family, and the encoded protein is involved in regulation of the cell cycle. Disruption of this gene is associated with primary ciliary dyskinesia-19. Alternative splicing results in multiple transcript variants. This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 symbol is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes. [provided by RefSeq, Jul 2014]., [RefSeq]; This publication corrected the mistaken attribution of uracil DNA glycosylase activity to this gene., [RefSeq, PubMed]; This publication initially attributed 'uracil-DNA glycosylase' activity to this gene and named it UNG2, but a later publication (PubMed ID: 8419333) more correctly identified UNG2/CCNO as a member of the cyclin protein family., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K1W5;Q0P6J2;Q9H6B0;Q9UMD5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005815 microtubule organizing center;GO:0000307 cyclin-dependent protein kinase holoenzyme complex",
        "go_biological_process": "GO:1903251 multi-ciliated epithelial cell differentiation;GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0060271 cilium assembly;GO:0000082 G1/S transition of mitotic cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "P22674-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P32320-1",
        "uniprot_id": "CDD_HUMAN",
        "mass": 16185.0,
        "length": 146,
        "protein_name": "Cytidine deaminase",
        "gene_name": "CDA",
        "organism": "Human",
        "refseq_name": "cytidine deaminase",
        "refseq_ac": "NP_001776",
        "gene_names_uniprotkb": "CDA; CDD",
        "gene_names_refseq": "CDA; CDD",
        "protein_names_uniprotkb": "Cytidine deaminase; 3.5.4.5; Cytidine aminohydrolase",
        "protein_names_refseq": "cytidine aminohydrolase; cytidine deaminase; cytosine nucleoside deaminase; small cytidine deaminase",
        "tax_id": 9606,
        "disease": "stomach cancer (Disease Ontology:DOID:10534); lung non-small cell carcinoma (Disease Ontology:DOID:3908)",
        "pathway": " (hsa:978);  (R-HSA-6798695);  (R-HSA-73614)",
        "pathway_count": 3,
        "publication_count": 58,
        "publication_id_list": "1063125;11306702;12199906;12429345;12808445;12849978;1406603;14609716;14725767;15130468;15689149;15733844;1590793;1597187;19291308;195585;1996353;20068231;2026611;20722631;22844363;23650620;24841663;2539852;2542307;2548513;26354033;2844225;29393594;29557506;30484775;32161166;32807821;32983136;33214551;3335503;3372530;33968037;34019948;34171305;35051231;35318648;36215666;36284347;36329350;37282621;37938771;38294491;7284378;7488099;7923172;8340387;8422236;8692836;9596658;9804782;9878810;9989599",
        "class_list": "",
        "function": "A decrease in NAMPT activity impairs basal PARP-1 activity in cytidine deaminase deficient-cells, independently of NAD(.) Publication Status: Online-Only, [RefSeq, PubMed]; Cytidine Deaminase Resolves Replicative Stress and Protects Pancreatic Cancer from DNA-Targeting Drugs., [RefSeq, PubMed]; Seven-membered ring nucleobases as inhibitors of human cytidine deaminase and APOBEC3A. Publication Status: Online-Only, [RefSeq, PubMed]; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis., [UniProtKB, PubMed, PubMed]; This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]., [RefSeq]; Upregulation of cytidine deaminase in NAT1 knockout breast cancer cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "1.8.3.2;3.4.19.12;3.6.4.13;2.7.1.35;1.1.1.42;2.4.2.1;3.4.21.46;3.4.21.-;1.16.3.1;1.11.1.6;4.1.2.13;2.4.1.1;5.3.1.9;5.1.3.-;3.4.23.5;3.4.22.52;2.4.2.7;3.4.22.1;3.6.4.10;3.2.1.31;2.5.1.18;2.7.10.2;1.13.11.-;1.13.11.34;3.3.2.6;3.4.11.4;1.11.1.7;1.1.1.205;4.2.99.18;5.6.2.4;3.6.5.-;4.2.1.24;3.4.19.1;5.3.2.1;5.3.3.12;2.7.11.1;2.7.1.40;3.4.24.35;3.1.6.14;3.1.6.12;3.2.1.23;2.7.1.11;5.4.2.11;5.4.2.4;2.7.4.6;2.7.13.3;3.4.24.34;3.4.22.27;2.7.11.24;3.1.3.48;3.5.4.5;3.4.21.4;5.4.2.2;2.4.1.186;3.6.1.-;2.7.1.1;2.7.1.-;2.3.3.8;3.6.4.6;3.2.1.17;5.2.1.8;3.1.1.47;3.1.1.-;3.5.4.6;1.11.1.24;3.2.1.14;2.7.11.39;3.5.1.23;3.5.1.-;3.5.1.109;2.7.11.22;2.7.11.23;2.3.2.5;2.3.2.26;3.6.1.6;3.4.19.9;5.4.2.7;3.4.25.1;2.1.1.348;2.1.1.9;3.5.1.3;2.3.2.27;3.4.18.1;4.1.2.4",
        "go_molecular_function": "GO:0004126 cytidine deaminase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0001882 nucleoside binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0034774 secretory granule lumen;GO:1904813 ficolin-1-rich granule lumen;GO:1904724 tertiary granule lumen",
        "go_biological_process": "GO:0008655 pyrimidine-containing compound salvage;GO:0019858 cytosine metabolic process;GO:0044206 UMP salvage;GO:0071217 cellular response to external biotic stimulus;GO:0006248 CMP catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "P32320-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P51685-1",
        "uniprot_id": "CCR8_HUMAN",
        "mass": 40844.0,
        "length": 355,
        "protein_name": "C-C chemokine receptor type 8",
        "gene_name": "CCR8",
        "organism": "Human",
        "refseq_name": "C-C chemokine receptor type 8",
        "refseq_ac": "NP_005192",
        "gene_names_uniprotkb": "CCR8; CKRL1; CMKBR8; CMKBRL2",
        "gene_names_refseq": "CC-CKR-8; CCR-8; CCR8; CDw198; CKRL1; CMKBR8; CMKBRL2; CY6; GPRCY6; TER1",
        "protein_names_uniprotkb": "C-C chemokine receptor type 8; C-C CKR-8; CC chemokine receptor CHEMR1; CC-CKR-8; CCR-8; CKR-L1; CMKBRL2; Chemokine receptor-like 1; GPR-CY6; GPRCY6; TER1",
        "protein_names_refseq": "C-C chemokine receptor type 8; CC chemokine receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor chemr1; chemokine (C-C motif) receptor 8; chemokine (C-C) receptor 8; chemokine (C-C) receptor-like 2; chemokine receptor-like 1",
        "tax_id": 9606,
        "disease": "asthma (Disease Ontology:DOID:2841); pulmonary fibrosis (Disease Ontology:DOID:3770)",
        "pathway": " (hsa:1237);  (R-HSA-380108);  (R-HSA-418594)",
        "pathway_count": 3,
        "publication_count": 91,
        "publication_id_list": "10229797;10377196;10540332;10640743;10706668;10725696;10725697;10781587;11007482;11060282;11237011;12120503;12149255;12551893;12554737;12884299;15067078;15951850;16107333;16634148;16923326;1744577;1840701;18434541;18577758;1891716;20002784;2078213;20947116;2217207;23999500;2423119;2534964;25892735;26375851;2748346;28228285;2834384;28832583;28904123;29242379;2970963;30315122;3098319;31844290;32350084;32357974;3260265;32897882;32983136;33912179;34185709;34357683;34509645;34932366;35041514;36284347;38040762;38231448;38306437;38985857;39259753;39894887;7602097;7622448;7642634;7679328;7851893;7875320;7937899;8015379;8048929;8383238;8406495;8639485;8816377;8849694;8886020;8977299;9024663;9164944;9166430;9169459;9207005;9276730;9390561;9463416;9469461;9521068;9618518;9834206",
        "class_list": "",
        "function": "(Microbial infection) Acts as a coreceptor for HIV-1 and HIV-2 viruses., [UniProtKB, PubMed]; (Microbial infection) Acts as a receptor for Kaposi virus protein vCCL1/K6 and thereby inhibits apoptosis in the targeted cells., [UniProtKB, PubMed]; Cryo-EM Structure and Biochemical Analysis of the Human Chemokine Receptor CCR8., [RefSeq, PubMed]; Development of a cellular model to study CCR8 signaling in tumor-infiltrating regulatory T cells. Publication Status: Online-Only, [RefSeq, PubMed]; G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18 (PubMed:23999500, PubMed:35041514). Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells (PubMed:23999500). In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways (PubMed:35041514). Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; The chemokine receptor CCR8 is not a high-affinity receptor for the human chemokine CCL18. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008]., [RefSeq]; Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RC64;Q3KNQ8;Q3KNR3;Q9BYX5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004950 chemokine receptor activity;GO:0015026 coreceptor activity;GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0006935 chemotaxis;GO:0006955 immune response;GO:0007155 cell adhesion;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration",
        "synthesized_glycan_count": 0,
        "hit_score": 9.4,
        "record_id": "P51685-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86SX3-1",
        "uniprot_id": "TEDC1_HUMAN",
        "mass": 54231.0,
        "length": 495,
        "protein_name": "Tubulin epsilon and delta complex protein 1",
        "gene_name": "TEDC1",
        "organism": "Human",
        "refseq_name": "tubulin epsilon and delta complex protein 1 isoform 1",
        "refseq_ac": "NP_001128347",
        "gene_names_uniprotkb": "TEDC1; C14orf80",
        "gene_names_refseq": "C14orf80; TEDC1",
        "protein_names_uniprotkb": "Tubulin epsilon and delta complex protein 1",
        "protein_names_refseq": "tubulin epsilon and delta complex protein 1 isoform 1; tubulin epsilon and delta complex protein 1; uncharacterized protein C14orf80",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283643)",
        "pathway_count": 1,
        "publication_count": 37,
        "publication_id_list": "11237011;24715725;25505266;26154972;26811146;26992070;27846572;28218747;28228285;28796488;28904123;29242379;29437277;29557506;30315122;30410026;31844290;31848261;31937595;31998317;32157095;32387766;32488085;32502341;33141586;33298915;33691108;33717175;33936100;33968037;34087483;34211107;34932366;35051231;36010968;36241641;38252227",
        "class_list": "",
        "function": "Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability (By similarity). May play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F (PubMed:28796488)., [UniProtKB, UniProtKB, PubMed]; Second report of TEDC1-related microcephaly caused by a novel biallelic mutation in an Iranian consanguineous family. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5MDG3;E9PAQ4;Q86TT3;Q86TT4;Q86TT5;Q96B41;Q9H7H4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0005814 centriole",
        "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0007010 cytoskeleton organization;GO:0000226 microtubule cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 3.8,
        "record_id": "Q86SX3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86U37-1",
        "uniprot_id": "CN023_HUMAN",
        "mass": 18828.0,
        "length": 167,
        "protein_name": "Uncharacterized protein encoded by LINC01551",
        "gene_name": "LINC01551",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "LINC01551; C14orf23",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Uncharacterized protein encoded by LINC01551",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 4,
        "publication_id_list": "29557506;32502341;34211107;38253038",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MT64",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q86U37-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86VU5-1",
        "uniprot_id": "CMTD1_HUMAN",
        "mass": 28809.0,
        "length": 262,
        "protein_name": "Catechol O-methyltransferase domain-containing protein 1",
        "gene_name": "COMTD1",
        "organism": "Human",
        "refseq_name": "catechol O-methyltransferase domain-containing protein 1",
        "refseq_ac": "NP_653190",
        "gene_names_uniprotkb": "COMTD1; PRO1558",
        "gene_names_refseq": "COMTD1; MT773",
        "protein_names_uniprotkb": "Catechol O-methyltransferase domain-containing protein 1; 2.1.1.-",
        "protein_names_refseq": "catechol O-methyltransferase domain-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:118881)",
        "pathway_count": 1,
        "publication_count": 32,
        "publication_id_list": "11237011;12975309;16385451;20877624;22645359;25576301;25880248;26992070;27846572;27920218;28228285;28510447;28832583;28834231;29242379;29314611;29508533;31844290;32157095;32350084;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33968037;33981976;34561969;35051231;35251023",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Putative O-methyltransferase., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8TE79",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0008171 O-methyltransferase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane",
        "go_biological_process": "GO:0032259 methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q86VU5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N769-1",
        "uniprot_id": "CN178_HUMAN",
        "mass": 13377.0,
        "length": 122,
        "protein_name": "Putative uncharacterized protein SLIRP-OT1",
        "gene_name": "SLIRP-OT1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "SLIRP-OT1; C14orf178",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative uncharacterized protein SLIRP-OT1; SLIRP overlapping transcript 1; Uncharacterized protein C14orf178",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "31217245;39894887",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2HIX2;Q3KNR7",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q8N769-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NCQ2-1",
        "uniprot_id": "CNAS1_HUMAN",
        "mass": 16070.0,
        "length": 148,
        "protein_name": "Uncharacterized protein CSNK1G2-AS1",
        "gene_name": "CSNK1G2-AS1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "CSNK1G2-AS1; C19orf34",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Uncharacterized protein CSNK1G2-AS1; CSNK1G2 antisense RNA 1; CSNK1G2 antisense gene protein 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "29393594",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "Q8NCQ2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A075B6I7-1",
        "uniprot_id": "LV548_HUMAN",
        "mass": 11247.0,
        "length": 105,
        "protein_name": "Probable non-functional immunoglobulin lambda variable 5-48",
        "gene_name": "IGLV5-48",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "IGLV5-48",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Probable non-functional immunoglobulin lambda variable 5-48",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "11340299;17576170;20176268;22158414;24600447;9619395",
        "class_list": "immunoglobin",
        "function": "Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 259,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "A0A075B6I7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A087WT02-1",
        "uniprot_id": "TVA92_HUMAN",
        "mass": 12289.0,
        "length": 112,
        "protein_name": "T cell receptor alpha variable 9-2",
        "gene_name": "TRAV9-2",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "TRAV9-2",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "T cell receptor alpha variable 9-2",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "15040585;20452950;23524462;24600447;25493333",
        "class_list": "",
        "function": "V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0042101 T cell receptor complex;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A0A087WT02-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A0B4J248-1",
        "uniprot_id": "TVA11_HUMAN",
        "mass": 11926.0,
        "length": 108,
        "protein_name": "T cell receptor alpha variable 1-1",
        "gene_name": "TRAV1-1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "TRAV1-1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "T cell receptor alpha variable 1-1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "15040585;20452950;23524462;24600447;25493333",
        "class_list": "",
        "function": "V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0042101 T cell receptor complex",
        "go_biological_process": "GO:0009617 response to bacterium;GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A0A0B4J248-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A1W2PQF6-1",
        "uniprot_id": "A0A1W2PQF6_HUMAN",
        "mass": 21605.0,
        "length": 198,
        "protein_name": "Immunoglobulin domain-containing protein",
        "gene_name": "",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin domain-containing protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0140375 immune receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "A0A1W2PQF6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A075B6L2-1",
        "uniprot_id": "TVG11_HUMAN",
        "mass": 13602.0,
        "length": 119,
        "protein_name": "Probable non-functional T cell receptor gamma variable 11",
        "gene_name": "TRGV11",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "TRGV11",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Probable non-functional T cell receptor gamma variable 11",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "23348415;24387714;24600447;25674089;28920588;9619395",
        "class_list": "",
        "function": "Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) gamma chain (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0042101 T cell receptor complex",
        "go_biological_process": "GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "A0A075B6L2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N4C6-1",
        "uniprot_id": "NIN_HUMAN",
        "mass": 243249.0,
        "length": 2090,
        "protein_name": "Ninein",
        "gene_name": "NIN",
        "organism": "Human",
        "refseq_name": "ninein isoform 6",
        "refseq_ac": "NP_057434",
        "gene_names_uniprotkb": "NIN; KIAA1565",
        "gene_names_refseq": "NIN; SCKL7",
        "protein_names_uniprotkb": "Ninein; GSK3B-interacting protein; Glycogen synthase kinase 3 beta-interacting protein; hNinein",
        "protein_names_refseq": "glycogen synthase kinase 3 beta-interacting protein; hNinein; ninein (GSK3B interacting protein); ninein centrosomal protein; ninein isoform 6",
        "tax_id": 9606,
        "disease": "Seckel syndrome 7 (Disease Ontology:DOID:0070011)",
        "pathway": " (hsa:51199)",
        "pathway_count": 1,
        "publication_count": 86,
        "publication_id_list": "11004522;11162463;11237011;11956314;12403812;12927815;14503922;14654843;15147888;15190203;17525332;18987736;19413330;19690332;20068231;20596670;22544926;22933543;23186163;23386061;23481700;24366607;25576301;25645385;25741725;26154972;26375851;26758079;26992070;27600516;27846572;27869121;27920218;28063628;28228285;28422092;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29786170;30315122;30379171;30429286;30524438;30765789;31217245;31530632;31844290;31848261;31937595;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33717175;33912179;33936100;33968037;34118594;34171305;34211107;34509645;34932366;35051231;35561310;35580925;36010968;36240223;37217939;37938771;38117588;9506584",
        "class_list": "",
        "function": "Beta3-Endonexin interacts with ninein in vascular endothelial cells to promote angiogenesis., [RefSeq, PubMed]; Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061)., [UniProtKB, PubMed, PubMed, PubMed]; Genetic susceptibility of common polymorphisms in NIN and SIGLEC5 to chronic periodontitis. Publication Status: Online-Only, [RefSeq, PubMed]; Ninein influences the rate of axonal growth and branching by affecting microtubule stability and dynamics., [RefSeq, PubMed]; Ninein promotes F-actin cup formation and inward phagosome movement during phagocytosis in macrophages., [RefSeq, PubMed]; This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 55,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NDB8;B7WPA3;C9JSB6;C9JSG2;C9JXL2;Q5BKU3;Q6P0P6;Q9BWU6;Q9C012;Q9C013;Q9C014;Q9H5I6;Q9HAT7;Q9HBY5;Q9HCK7;Q9UH61",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005525 GTP binding;GO:0005509 calcium ion binding;GO:0051011 microtubule minus-end binding",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045177 apical part of cell",
        "go_biological_process": "GO:0090222 centrosome-templated microtubule nucleation;GO:0008104 intracellular protein localization;GO:0051642 centrosome localization;GO:0010457 centriole-centriole cohesion;GO:0034454 microtubule anchoring at centrosome",
        "synthesized_glycan_count": 0,
        "hit_score": 9.4,
        "record_id": "Q8N4C6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NCA5-1",
        "uniprot_id": "FA98A_HUMAN",
        "mass": 55273.0,
        "length": 518,
        "protein_name": "Protein FAM98A",
        "gene_name": "FAM98A",
        "organism": "Human",
        "refseq_name": "protein FAM98A isoform 1",
        "refseq_ac": "NP_056290",
        "gene_names_uniprotkb": "FAM98A",
        "gene_names_refseq": "FAM98A",
        "protein_names_uniprotkb": "Protein FAM98A",
        "protein_names_refseq": "protein FAM98A isoform 1; protein FAM98A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:25940)",
        "pathway_count": 1,
        "publication_count": 60,
        "publication_id_list": "11237011;20112406;20305658;21740066;23481700;26728094;27600516;27920218;28040436;28063628;28228285;28510447;28649982;28832583;28834231;28855257;28860189;29242379;29314611;29393594;29557506;29632046;29769354;29786170;30192525;30315122;30429286;31114934;31154438;31217245;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32357974;32387766;32488085;32938616;33141586;33214551;33592498;33691108;33717175;33912179;33968037;34019948;34171305;34229054;34357683;34783205;35051231;35580925;36010968;36215666;36241641;36284347;38665916",
        "class_list": "",
        "function": "Circular RNA intraflagellar transport 80 facilitates endometrial cancer progression through modulating miR-545-3p/FAM98A signaling., [RefSeq, PubMed]; Mechanistically, it was demonstrated that miR-142-3p directly targeted FAM98A, and modulated its expression., [RefSeq, PubMed]; Positively stimulates PRMT1-induced protein arginine methylation (PubMed:28040436). Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity)., [UniProtKB, PubMed, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RNA2;Q9Y3Y6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0008276 protein methyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0072669 tRNA-splicing ligase complex",
        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0006479 protein methylation;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0032418 lysosome localization",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "Q8NCA5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9GZU7-1",
        "uniprot_id": "CTDS1_HUMAN",
        "mass": 29203.0,
        "length": 261,
        "protein_name": "Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1",
        "gene_name": "CTDSP1",
        "organism": "Human",
        "refseq_name": "carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 3",
        "refseq_ac": "NP_001193807",
        "gene_names_uniprotkb": "CTDSP1; NIF3; NLIIF; SCP1",
        "gene_names_refseq": "CTDSP1; NIF3; NLI-IF; NLIIF; SCP1",
        "protein_names_uniprotkb": "Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; 3.1.3.16; NLI-IF; NLI-interacting factor 3; Nuclear LIM interactor-interacting factor 3; SCP1; Small C-terminal domain phosphatase 1; Small CTD phosphatase 1",
        "protein_names_refseq": "CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1; NLI-interacting factor 3; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 3; nuclear LIM interactor-interacting factor 3; small C-terminal domain phosphatase 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:58190)",
        "pathway_count": 1,
        "publication_count": 39,
        "publication_id_list": "10967134;11237011;11950066;12721286;15304220;15681389;17157258;24715725;25081999;25576301;26154972;26992070;28228285;28904123;29242379;29557506;31217245;31844290;32157095;32350084;32357974;32897882;32973332;32983136;33043033;33592498;33912179;33981976;34079082;34262056;34357683;34932366;35051231;35251023;35318648;35580925;36010968;36241641;40596516",
        "class_list": "",
        "function": "C-terminal domain small phosphatase 1 (CTDSP1) regulates growth factor expression and axonal regeneration in peripheral nerve tissue. Publication Status: Online-Only, [RefSeq, PubMed]; Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein., [RefSeq, PubMed]; GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion., [RefSeq, PubMed]; Polymorphisms vary significantly between races; Not associated with TB susceptibility in Caucasians., [RefSeq, PubMed]; Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells., [UniProtKB, PubMed, PubMed]; Results show that REST/NRSF recruits SCPs to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells, [RefSeq, PubMed]; SCP1 may play a role in the regulation of gene expression, possibly by controlling the transition from initiation/capping to processive transcript elongation, [RefSeq, PubMed]; This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9IYG0;Q7Z5Q3;Q7Z5Q4",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.-;3.1.3.67;3.1.3.53;3.1.3.52;3.1.3.27;3.1.3.86;3.1.3.36;3.1.3.74",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity;GO:0004722 protein serine/threonine phosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006470 protein dephosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "Q9GZU7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A0X1KG70-1",
        "uniprot_id": "ORM2B_HUMAN",
        "mass": 35403.0,
        "length": 313,
        "protein_name": "Olfactory receptor 4M2B",
        "gene_name": "OR4M2B",
        "organism": "Human",
        "refseq_name": "olfactory receptor 4M2B",
        "refseq_ac": "NP_001382225",
        "gene_names_uniprotkb": "OR4M2B",
        "gene_names_refseq": "OR4M2B",
        "protein_names_uniprotkb": "Olfactory receptor 4M2B",
        "protein_names_refseq": "olfactory receptor 4M2B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:118568804)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "11237011",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "A0A0X1KG70-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A1B0GVD1-1",
        "uniprot_id": "F237B_HUMAN",
        "mass": 16331.0,
        "length": 139,
        "protein_name": "Protein FAM237B",
        "gene_name": "FAM237B",
        "organism": "Human",
        "refseq_name": "protein FAM237B precursor",
        "refseq_ac": "NP_001371166",
        "gene_names_uniprotkb": "FAM237B",
        "gene_names_refseq": "FAM237B",
        "protein_names_uniprotkb": "Protein FAM237B",
        "protein_names_refseq": "protein FAM237B precursor; protein FAM237B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:107986818)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "32713278;37689599",
        "class_list": "",
        "function": "A Pilot Screen of a Novel Peptide Hormone Library Identified Candidate GPR83 Ligands., [RefSeq, PubMed]; May activate the G protein-coupled receptor GPR83 (PubMed:32713278, PubMed:37689599). Has orexigenic activity. Plays a role in the brain-adipose axis that controls feeding (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "A0A1B0GVD1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A1B0GWG4-1",
        "uniprot_id": "SRTM2_HUMAN",
        "mass": 10219.0,
        "length": 90,
        "protein_name": "Serine-rich and transmembrane domain-containing protein 2",
        "gene_name": "SERTM2",
        "organism": "Human",
        "refseq_name": "serine-rich and transmembrane domain-containing protein 2",
        "refseq_ac": "NP_001341402",
        "gene_names_uniprotkb": "SERTM2",
        "gene_names_refseq": "CARDEL; DKFZp686D0853; LINC00890; SERTM2",
        "protein_names_uniprotkb": "Serine-rich and transmembrane domain-containing protein 2",
        "protein_names_refseq": "CARdiac DEvelopment Long non-coding RNA; long intergenic non-protein coding RNA 890; serine-rich and transmembrane domain-containing protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:401613)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "11230166;38920678",
        "class_list": "",
        "function": "Cardiac Development Long Non-Coding RNA (CARDEL) Is Activated during Human Heart Development and Contributes to Cardiac Specification and Homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Promotes GDNF-mediated spinal cord motor neuron subtype specification, ensuring the maintenance of ETV4-expressing motor neurons. Affects the resting membrane potential and excitability of motor neurons., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007399 nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "A0A1B0GWG4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A1W2PQ27-1",
        "uniprot_id": "S72L1_HUMAN",
        "mass": 22511.0,
        "length": 194,
        "protein_name": "RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 1",
        "gene_name": "SSU72L1",
        "organism": "Human",
        "refseq_name": "RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 1",
        "refseq_ac": "NP_001400927",
        "gene_names_uniprotkb": "SSU72L1",
        "gene_names_refseq": "SSU72L1; SSU72P7",
        "protein_names_uniprotkb": "RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 1; 3.1.3.16; CTD phosphatase SSU72L1; RNA polymerase II subunit A C-terminal domain phosphatase SSU72L1",
        "protein_names_refseq": "CTD phosphatase SSU72L1; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 1; RNA polymerase II subunit A C-terminal domain phosphatase SSU72L1; SSU72 RNA polymerase II CTD phosphatase homolog pseudogene 7; SSU72 pseudogene 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:390033)",
        "pathway_count": 1,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.-;3.1.3.67;3.1.3.53;3.1.3.52;3.1.3.27;3.1.3.86;3.1.3.36;3.1.3.74",
        "go_molecular_function": "GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity",
        "go_cellular_component": "GO:0005847 mRNA cleavage and polyadenylation specificity factor complex",
        "go_biological_process": "GO:0006369 termination of RNA polymerase II transcription;GO:0031124 mRNA 3'-end processing",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "A0A1W2PQ27-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A075B7B8-1",
        "uniprot_id": "A0A075B7B8_HUMAN",
        "mass": 12875.0,
        "length": 117,
        "protein_name": "Immunoglobulin heavy variable 3/OR16-12 (non-functional)",
        "gene_name": "IGHV3OR16-12",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "IGHV3OR16-12",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 3/OR16-12 (non-functional)",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "11237011",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "A0A075B7B8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A075B6T8-1",
        "uniprot_id": "TVA91_HUMAN",
        "mass": 12354.0,
        "length": 112,
        "protein_name": "T cell receptor alpha variable 9-1",
        "gene_name": "TRAV9-1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "TRAV9-1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "T cell receptor alpha variable 9-1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "15040585;20452950;23524462;24600447;25493333;35051231",
        "class_list": "",
        "function": "V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0042101 T cell receptor complex;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "A0A075B6T8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A075B734-1",
        "uniprot_id": "AQP7B_HUMAN",
        "mass": 38044.0,
        "length": 346,
        "protein_name": "Putative aquaporin-7B",
        "gene_name": "AQP7B",
        "organism": "Human",
        "refseq_name": "putative aquaporin-7B",
        "refseq_ac": "NP_001369426",
        "gene_names_uniprotkb": "AQP7B",
        "gene_names_refseq": "AQP7B",
        "protein_names_uniprotkb": "Putative aquaporin-7B",
        "protein_names_refseq": "putative aquaporin-7B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100509620)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "11237011",
        "class_list": "",
        "function": "Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8WX69",
        "ec_number_list": "",
        "go_molecular_function": "GO:0015250 water channel activity;GO:0015254 glycerol channel activity;GO:0015204 urea transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane",
        "go_biological_process": "GO:0006833 water transport;GO:0015793 glycerol transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "A0A075B734-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A075B6I3-1",
        "uniprot_id": "LVK55_HUMAN",
        "mass": 13202.0,
        "length": 123,
        "protein_name": "Probable non-functional immunoglobulin lambda variable 11-55",
        "gene_name": "IGLV11-55",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "IGLV11-55",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Probable non-functional immunoglobulin lambda variable 11-55",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "11340299;17576170;20176268;22158414;24600447;9619395",
        "class_list": "immunoglobin",
        "function": "Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 170,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "A0A075B6I3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A1W2PRV1-1",
        "uniprot_id": "TFKL3_HUMAN",
        "mass": 21660.0,
        "length": 198,
        "protein_name": "TATA-box-binding protein-associated factor 11-like protein 3",
        "gene_name": "TAF11L3",
        "organism": "Human",
        "refseq_name": "TATA-box-binding protein-associated factor 11-like protein 3",
        "refseq_ac": "NP_001388629",
        "gene_names_uniprotkb": "TAF11L3",
        "gene_names_refseq": "TAF11L3",
        "protein_names_uniprotkb": "TATA-box-binding protein-associated factor 11-like protein 3",
        "protein_names_refseq": "TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa pseudogene; TATA-box-binding protein-associated factor 11-like protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:646103)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "21078170",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046982 protein heterodimerization activity",
        "go_cellular_component": "GO:0005669 transcription factor TFIID complex",
        "go_biological_process": "GO:0051123 RNA polymerase II preinitiation complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "A0A1W2PRV1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A1B0GX95-1",
        "uniprot_id": "TVB74_HUMAN",
        "mass": 12658.0,
        "length": 115,
        "protein_name": "T cell receptor beta variable 7-4",
        "gene_name": "TRBV7-4",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "TRBV7-4",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "T cell receptor beta variable 7-4",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "15040585;20452950;23524462;24600447;25493333;38253038",
        "class_list": "",
        "function": "V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0042101 T cell receptor complex",
        "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "A0A1B0GX95-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A1B0GVB3-1",
        "uniprot_id": "CG078_HUMAN",
        "mass": 30427.0,
        "length": 256,
        "protein_name": "Putative uncharacterized protein C7orf78",
        "gene_name": "C7orf78",
        "organism": "Human",
        "refseq_name": "putative uncharacterized protein C7orf78 isoform 1",
        "refseq_ac": "NP_001373441",
        "gene_names_uniprotkb": "C7orf78",
        "gene_names_refseq": "C7orf78",
        "protein_names_uniprotkb": "Putative uncharacterized protein C7orf78",
        "protein_names_refseq": "putative uncharacterized protein C7orf78 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:102725191)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "11237011",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A1B0GW04",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "A0A1B0GVB3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A1B0GTU1-1",
        "uniprot_id": "ZC11B_HUMAN",
        "mass": 88937.0,
        "length": 805,
        "protein_name": "Zinc finger CCCH domain-containing protein 11B",
        "gene_name": "ZC3H11B",
        "organism": "Human",
        "refseq_name": "zinc finger CCCH domain-containing protein 11B",
        "refseq_ac": "NP_001342386",
        "gene_names_uniprotkb": "ZC3H11B; ZC3HDC11B",
        "gene_names_refseq": "ZC3H11B; ZC3HDC11B",
        "protein_names_uniprotkb": "Zinc finger CCCH domain-containing protein 11B",
        "protein_names_refseq": "zinc finger CCCH domain-containing protein 11B; zinc finger CCCH-type domain containing 11B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:643136)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "29557506;31300455;31844290;32350084;32502341",
        "class_list": "",
        "function": "Association of the ZC3H11B, ZFHX1B and SNTB1 genes with myopia of different severities., [RefSeq, PubMed]; May play a role in mRNA transport., [UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A0A1B0GTU1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P17029-1",
        "uniprot_id": "ZKSC1_HUMAN",
        "mass": 63630.0,
        "length": 563,
        "protein_name": "Zinc finger protein with KRAB and SCAN domains 1",
        "gene_name": "ZKSCAN1",
        "organism": "Human",
        "refseq_name": "zinc finger protein with KRAB and SCAN domains 1 isoform a",
        "refseq_ac": "NP_001333510",
        "gene_names_uniprotkb": "ZKSCAN1; KOX18; ZNF139; ZNF36",
        "gene_names_refseq": "KOX18; PHZ-37; ZKSCAN1; ZNF139; ZNF36; ZSCAN33",
        "protein_names_uniprotkb": "Zinc finger protein with KRAB and SCAN domains 1; Zinc finger protein 139; Zinc finger protein 36; Zinc finger protein KOX18",
        "protein_names_refseq": "zinc finger protein 139; zinc finger protein 36 (KOX 18); zinc finger protein with KRAB and SCAN domains 1 isoform a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7586);  (R-HSA-212436)",
        "pathway_count": 2,
        "publication_count": 66,
        "publication_id_list": "10235266;10330177;11237011;11395415;14519192;15175151;15896744;16606702;16719718;17081983;17525332;18669648;18691976;18707149;19007248;19369195;19690332;20068231;2163759;2288909;23186163;24275569;24715725;25218447;25772364;27600516;28218747;28228285;28514659;28832583;28904123;29242379;29437277;29493099;29557506;29786170;29789417;30315122;30379171;31092671;31154438;31530632;31844290;31848261;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;33439397;33592498;33691108;35051231;35580925;35705054;36010968;36241641;36691031;7557990;8183939;8769649;9637681;9653119",
        "class_list": "",
        "function": "A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR. Publication Status: Online-Only, [RefSeq, PubMed]; CircZKSCAN1 Suppresses Hepatocellular Carcinoma Tumorigenesis by Regulating miR-873-5p/Downregulation of Deleted in Liver Cancer 1., [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the Kruppel C2H2-type zinc-finger family of proteins. This encoded protein may function as a transcription factor that regulates the expression of GABA type-A receptors in the brain. Transcripts from this gene have been shown to form stable and abundant circular RNAs. Elevated expression of this gene has been observed in gastric cancer and the encoded protein may stimulate migration and invasion of human gastric cancer cells. [provided by RefSeq, Oct 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D294;P52745;Q2M1U1;Q8TBW5;Q8TEK7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "P17029-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P10073-1",
        "uniprot_id": "ZSC22_HUMAN",
        "mass": 54561.0,
        "length": 491,
        "protein_name": "Zinc finger and SCAN domain-containing protein 22",
        "gene_name": "ZSCAN22",
        "organism": "Human",
        "refseq_name": "zinc finger and SCAN domain-containing protein 22 isoform 1",
        "refseq_ac": "NP_001308045",
        "gene_names_uniprotkb": "ZSCAN22; HKR2; ZNF50",
        "gene_names_refseq": "HKR2; ZNF50; ZSCAN22",
        "protein_names_uniprotkb": "Zinc finger and SCAN domain-containing protein 22; Krueppel-related zinc finger protein 2; Protein HKR2; Zinc finger protein 50",
        "protein_names_refseq": "GLI-Kruppel family member HKR2; krueppel-related zinc finger protein 2; zinc finger and SCAN domain-containing protein 22 isoform 1; zinc finger and SCAN domain-containing protein 22; zinc finger protein 50",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:342945)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "1505991;17525332;23186163;23481700;28218747;2850480;28832583;29437277;30315122;31844290;32488085;32502341;33141586;33298915;33968037",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q15922;Q7Z3L8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "P10073-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95471-1",
        "uniprot_id": "CLD7_HUMAN",
        "mass": 22418.0,
        "length": 211,
        "protein_name": "Claudin-7",
        "gene_name": "CLDN7",
        "organism": "Human",
        "refseq_name": "claudin-7 isoform 1",
        "refseq_ac": "NP_001171951",
        "gene_names_uniprotkb": "CLDN7; CEPTRL2; CPETRL2",
        "gene_names_refseq": "CEPTRL2; CLDN-7; CLDN7; CPETRL2; Hs.84359; claudin-1",
        "protein_names_uniprotkb": "Claudin-7; CLDN-7",
        "protein_names_refseq": "claudin-7 isoform 1; clostridium perfringens enterotoxin receptor-like 2; epididymis secretory sperm binding protein",
        "tax_id": 9606,
        "disease": "myopia (Disease Ontology:DOID:11830); primary pulmonary hypertension (Disease Ontology:DOID:14557); asthma (Disease Ontology:DOID:2841); lung disease (Disease Ontology:DOID:850)",
        "pathway": " (hsa:1366);  (R-HSA-420029)",
        "pathway_count": 2,
        "publication_count": 19,
        "publication_id_list": "11237011;11447115;11964389;12673207;12953056;14502431;16054130;16129888;20375010;29557506;29786170;30779550;33968037;34763991;34774484;35051231;36241641;36275703;38050671",
        "class_list": "",
        "function": "Claudin-7 in keratinocytes is downregulated by the inhibition of HMG-CoA reductase and is highly expressed in the stratum granulosum of the psoriatic epidermis., [RefSeq, PubMed]; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Hypoxia-inducible microRNA-155 negatively regulates epithelial barrier in eosinophilic esophagitis by suppressing tight junction claudin-7., [RefSeq, PubMed]; Matrix metalloproteinase 7 contributes to intestinal barrier dysfunction by degrading tight junction protein Claudin-7. Publication Status: Online-Only, [RefSeq, PubMed]; N-glycosylation status of Trop2 impacts its surface density, interaction with claudin-7 and exosomal release., [RefSeq, PubMed]; Plays a major role in tight junction-specific obliteration of the intercellular space., [UniProtKB]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R9X7;D3DTP0;Q6IPN3;Q7Z4Y7;Q9BVN0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016323 basolateral plasma membrane;GO:0030054 cell junction;GO:0016328 lateral plasma membrane",
        "go_biological_process": "GO:0045216 cell-cell junction organization;GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "O95471-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A075B6Z1-1",
        "uniprot_id": "A0A075B6Z1_HUMAN",
        "mass": 1998.0,
        "length": 19,
        "protein_name": "T cell receptor alpha joining 20",
        "gene_name": "TRAJ20",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "TRAJ20",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "T cell receptor alpha joining 20",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "11237011",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "A0A075B6Z1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A075B7D4-1",
        "uniprot_id": "A0A075B7D4_HUMAN",
        "mass": 12535.0,
        "length": 117,
        "protein_name": "Immunoglobulin kappa variable 1/OR2-108 (non-functional)",
        "gene_name": "IGKV1OR2-108",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "IGKV1OR2-108",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin kappa variable 1/OR2-108 (non-functional)",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "11237011",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "A0A075B7D4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A0B4J237-1",
        "uniprot_id": "TVA82_HUMAN",
        "mass": 12429.0,
        "length": 113,
        "protein_name": "T cell receptor alpha variable 8-2",
        "gene_name": "TRAV8-2",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "TRAV8-2",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "T cell receptor alpha variable 8-2",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "15040585;20452950;23524462;24600447;25493333",
        "class_list": "",
        "function": "V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0042101 T cell receptor complex;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A0A0B4J237-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A1B0GVV1-1",
        "uniprot_id": "SIM35_HUMAN",
        "mass": 9379.0,
        "length": 85,
        "protein_name": "Small integral membrane protein 35",
        "gene_name": "SMIM35",
        "organism": "Human",
        "refseq_name": "small integral membrane protein 35 isoform 3",
        "refseq_ac": "NP_001381094",
        "gene_names_uniprotkb": "SMIM35; TMPRSS4-AS1",
        "gene_names_refseq": "SMIM35; TMPRSS4-AS1",
        "protein_names_uniprotkb": "Small integral membrane protein 35; TMPRSS4 antisense RNA 1",
        "protein_names_refseq": "TMPRSS4 antisense RNA 1 (non-protein coding); small integral membrane protein 35 isoform 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100526771)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "35580925",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "A0A1B0GVV1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A075B6I6-1",
        "uniprot_id": "LV150_HUMAN",
        "mass": 12339.0,
        "length": 118,
        "protein_name": "Probable non-functional immunoglobulin lambda variable 1-50",
        "gene_name": "IGLV1-50",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "IGLV1-50",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Probable non-functional immunoglobulin lambda variable 1-50",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 9,
        "publication_id_list": "11340299;17576170;20176268;22158414;24600447;32350084;32983136;35580925;9619395",
        "class_list": "immunoglobin",
        "function": "Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 168,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "A0A075B6I6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A087WT03-1",
        "uniprot_id": "TVAZ1_HUMAN",
        "mass": 12306.0,
        "length": 109,
        "protein_name": "T cell receptor alpha variable 26-1",
        "gene_name": "TRAV26-1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "TRAV26-1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "T cell receptor alpha variable 26-1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "15040585;20452950;23524462;24600447;25493333",
        "class_list": "",
        "function": "V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0042101 T cell receptor complex",
        "go_biological_process": "GO:0009617 response to bacterium;GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A0A087WT03-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A0G2JN68-1",
        "uniprot_id": "A0A0G2JN68_HUMAN",
        "mass": 40694.0,
        "length": 375,
        "protein_name": "Killer cell immunoglobulin-like receptor 2DL5B",
        "gene_name": "KIR2DL5B",
        "organism": "Human",
        "refseq_name": "killer cell immunoglobulin-like receptor 2DL5B isoform X5",
        "refseq_ac": "XP_054189425",
        "gene_names_uniprotkb": "KIR2DL5B",
        "gene_names_refseq": "KIR2DL5.2; KIR2DL5B; KIR2DL5; KIR2DLX",
        "protein_names_uniprotkb": "Killer cell immunoglobulin-like receptor 2DL5B",
        "protein_names_refseq": "killer cell immunoglobulin-like receptor 2DL5B isoform X5",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "A0A0G2JN68-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A1B0GX31-1",
        "uniprot_id": "TVB76_HUMAN",
        "mass": 12827.0,
        "length": 115,
        "protein_name": "T cell receptor beta variable 7-6",
        "gene_name": "TRBV7-6",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "TRBV7-6",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "T cell receptor beta variable 7-6",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "15040585;20452950;23524462;24600447;25493333",
        "class_list": "",
        "function": "V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0042101 T cell receptor complex",
        "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A0A1B0GX31-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "C9JLR9-1",
        "uniprot_id": "ZFTA_HUMAN",
        "mass": 73197.0,
        "length": 678,
        "protein_name": "Zinc finger translocation-associated protein",
        "gene_name": "ZFTA",
        "organism": "Human",
        "refseq_name": "zinc finger translocation-associated protein",
        "refseq_ac": "NP_001138408",
        "gene_names_uniprotkb": "ZFTA; C11orf95",
        "gene_names_refseq": "C11orf95; ZFTA",
        "protein_names_uniprotkb": "Zinc finger translocation-associated protein; ZFTA",
        "protein_names_refseq": "uncharacterized protein C11orf95; zinc finger translocation-associated protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:65998)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "11237011;20607705;23672313;24553141;24562983;28649982;30429286;31844290;31848261;32157095;32357974;33576087;33685520;33968037;34433824;35051231;38581034",
        "class_list": "",
        "function": "Based on a recurrent translocation t(11;16)(q13;p13), the C11orf95-MKL2 fusion gene has been found in eight further cases of chondroid lipomas., [RefSeq, PubMed]; C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation. Erratum:[Acta Neuropathol Commun. 2021 May 27;9(1):100. doi: 10.1186/s40478-021-01157-y. PMID: 34044883] Publication Status: Online-Only, [RefSeq, PubMed]; C11orf95-RELA fusions represent a unique novel mechanism leading to pathological activation of NF-kappaB signaling in supratentorial ependymomas., [RefSeq, PubMed]; CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas. Publication Status: Online-Only, [RefSeq, PubMed]; Ependymoma-like tumor with mesenchymal differentiation harboring C11orf95-NCOA1/2 or -RELA fusion: A hitherto unclassified tumor related to ependymoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NLS7;Q3C1V4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "C9JLR9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P09093-1",
        "uniprot_id": "CEL3A_HUMAN",
        "mass": 29489.0,
        "length": 270,
        "protein_name": "Chymotrypsin-like elastase family member 3A",
        "gene_name": "CELA3A",
        "organism": "Human",
        "refseq_name": "chymotrypsin-like elastase family member 3A preproprotein",
        "refseq_ac": "NP_005738",
        "gene_names_uniprotkb": "CELA3A; ELA3A; ELA3",
        "gene_names_refseq": "CELA3A; ELA3A; ELA3",
        "protein_names_uniprotkb": "Chymotrypsin-like elastase family member 3A; 3.4.21.70; Elastase IIIA; Elastase-3A; Protease E",
        "protein_names_refseq": "chymotrypsin like elastase family member 3A; chymotrypsin-like elastase family member 3A preproprotein; elastase 1; elastase 3A, pancreatic; elastase IIIA; elastase-3A; protease E",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10136)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11237011;12373299;2460440;27358403;27999401;2826474;29485866;29557506;30192525;35051231",
        "class_list": "",
        "function": "Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2., [RefSeq, PubMed]; Efficient protease with alanine specificity but only little elastolytic activity., [UniProtKB]; Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. [provided by RefSeq, Jul 2008]., [RefSeq]; Expression of PE IIIA and its splicing variants in pancreatic carcinoma cells, [RefSeq, PubMed]; Variants affecting amino-acid position 241 in CELA3A and CELA3B are not associated with chronic pancreatitis, indicating that changes in complex formation between proelastases and procarboxypeptidases do not alter pancreatitis risk. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AQ53;Q9BRW4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "P09093-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15551-1",
        "uniprot_id": "CLD3_HUMAN",
        "mass": 23319.0,
        "length": 220,
        "protein_name": "Claudin-3",
        "gene_name": "CLDN3",
        "organism": "Human",
        "refseq_name": "claudin-3",
        "refseq_ac": "NP_001297",
        "gene_names_uniprotkb": "CLDN3; C7orf1; CPETR2",
        "gene_names_refseq": "C7orf1; CLDN3; CPE-R2; CPETR2; HRVP1; RVP1",
        "protein_names_uniprotkb": "Claudin-3; CPE-R 2; CPE-receptor 2; Clostridium perfringens enterotoxin receptor 2; Rat ventral prostate.1 protein homolog; hRVP1",
        "protein_names_refseq": "CPE-R 2; CPE-receptor 2; Clostridium perfringens enterotoxin receptor 2; claudin-3; ventral prostate.1 protein homolog; ventral prostate.1-like protein",
        "tax_id": 9606,
        "disease": "peptic esophagitis (Disease Ontology:DOID:13976)",
        "pathway": " (hsa:1365);  (R-HSA-420029)",
        "pathway_count": 2,
        "publication_count": 23,
        "publication_id_list": "11447115;11964389;12953056;15905176;16129888;18083107;20166139;24275569;25576301;28028216;29242379;29557506;29786170;30734065;34087483;35051231;35318648;36008380;36606388;37578554;38010872;9334247;9441748",
        "class_list": "",
        "function": "Barrier-forming claudin. Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity., [UniProtKB, PubMed]; Claudin-3 facilitates the progression and mediates the tumorigenic effects of TGF-beta in glioblastoma multiforme. Publication Status: Online-Only, [RefSeq, PubMed]; Claudin-3 is a novel intestinal integrity marker in patients with alopecia areata: Correlation with the disease severity., [RefSeq, PubMed]; Loss of claudin-3 expression increases colitis risk by promoting Gut Dysbiosis., [RefSeq, PubMed]; Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0098632 cell-cell adhesion mediator activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0030054 cell junction",
        "go_biological_process": "GO:0090559 regulation of membrane permeability;GO:0007155 cell adhesion;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "O15551-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95833-1",
        "uniprot_id": "CLIC3_HUMAN",
        "mass": 26648.0,
        "length": 236,
        "protein_name": "Chloride intracellular channel protein 3",
        "gene_name": "CLIC3",
        "organism": "Human",
        "refseq_name": "chloride intracellular channel protein 3",
        "refseq_ac": "NP_004660",
        "gene_names_uniprotkb": "CLIC3",
        "gene_names_refseq": "CLIC3",
        "protein_names_uniprotkb": "Chloride intracellular channel protein 3; 1.8.-.-; Glutaredoxin-like oxidoreductase CLIC3",
        "protein_names_refseq": "chloride intracellular channel 3; chloride intracellular channel protein 3; glutaredoxin-like oxidoreductase CLIC3",
        "tax_id": 9606,
        "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); alcohol use disorder (Disease Ontology:DOID:1574); primary ciliary dyskinesia (Disease Ontology:DOID:9562)",
        "pathway": " (hsa:9022)",
        "pathway_count": 1,
        "publication_count": 28,
        "publication_id_list": "17027078;20146363;23186163;25548167;26375851;27862975;28198360;29557506;29786170;30429286;30524438;31217245;31848261;32066374;32161166;32387766;32938616;33123756;33592498;33968037;34766585;35051231;35238065;35580925;36241641;37759794;38182571;9880541",
        "class_list": "",
        "function": "CLIC3 facilitates chloride ion movement and regulates cellular processes associated with the movement of chloride in placental and fetal membrane cells., [RefSeq, PubMed]; CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine modification of p21 mRNA and promote bladder cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]., [RefSeq]; Chloride intercellular channel 3 suppression-mediated macrophage polarization: a potential indicator of poor prognosis of hepatitis B virus-related acute-on-chronic liver failure., [RefSeq, PubMed]; Identification of chloride intracellular channels as prognostic factors correlated with immune infiltration in hepatocellular carcinoma using bioinformatics analysis., [RefSeq, PubMed]; In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:28198360, PubMed:37759794). Reduced in a glutathione-dependent way and secreted into the extracellular matrix where it activates TGM2 and promotes blood vessel growth during tissue remodeling as occurs in tumorigenesis. Can reduce specific cysteines in TGM2 and regulate cofactor binding (PubMed:28198360). Can insert into membranes and form outwardly rectifying chloride ion channels. May participate in cellular growth control., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Pathophysiological properties of CLIC3 chloride channel in human gastric cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5SPZ7",
        "ec_number_list": "1.8.-.-;1.8.5.1;1.11.1.-;5.6.1.6",
        "go_molecular_function": "GO:0019153 protein-disulfide reductase (glutathione) activity;GO:0005254 chloride channel activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0007165 signal transduction;GO:0006821 chloride transport",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "O95833-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P09497-1",
        "uniprot_id": "CLCB_HUMAN",
        "mass": 25190.0,
        "length": 229,
        "protein_name": "Clathrin light chain B",
        "gene_name": "CLTB",
        "organism": "Human",
        "refseq_name": "clathrin light chain B isoform a",
        "refseq_ac": "NP_001825",
        "gene_names_uniprotkb": "CLTB",
        "gene_names_refseq": "CLTB; LCB",
        "protein_names_uniprotkb": "Clathrin light chain B; Lcb",
        "protein_names_refseq": "clathrin light chain B isoform a; clathrin, light chain (Lcb); clathrin, light polypeptide (Lcb)",
        "tax_id": 9606,
        "disease": "stroke (Disease Ontology:DOID:0051061); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); autoimmune disease of the nervous system (Disease Ontology:DOID:438); borna disease (Disease Ontology:DOID:5154); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:1212);  (R-HSA-190873);  (R-HSA-196025);  (R-HSA-3928665);  (R-HSA-432720);  (R-HSA-5099900);  (R-HSA-5140745);  (R-HSA-8856825);  (R-HSA-8856828)",
        "pathway_count": 9,
        "publication_count": 285,
        "publication_id_list": "10097102;10394364;10436022;10436028;10535736;10542231;10559856;10559861;10559924;10567358;10613896;10625686;10766823;10769163;10983987;11071885;11076969;11082044;11139587;11231140;11237011;11239472;11247302;11333915;11448999;11454741;11470803;11516654;11517213;11532990;11577110;11588219;11604418;11694590;11877457;11877461;11889126;11919637;11927540;11988742;11994746;12057195;12086608;12213833;12221107;12234931;12429842;12447393;12451172;12464600;12717448;12847086;12944396;12952949;12958364;12973357;1317852;14555962;14581451;14617351;14622578;14622579;14662753;14726597;15134832;15252009;15260957;15318165;15339664;15351694;1535555;15473838;15502812;15502813;15533940;15649145;15671180;15703209;15728179;15802264;15848800;15895077;15916959;16103228;16155256;16159959;16215232;16326391;16410077;16459302;16460808;16511561;16516836;16707488;16723738;16798879;16867982;16880396;16903783;17018281;17035995;17108328;17116749;17117926;17158794;17199046;17267500;17360967;17428795;17456551;17494869;17512409;17522231;17540576;17609109;17681954;17713526;17762867;17765681;17978091;18032517;18093523;18166656;18199683;18388313;1847920;18713744;18775314;18790740;18819912;18981233;19092055;19140243;19287005;19296720;19458185;19531498;19536138;19559397;19575674;19582886;19603039;19651769;1968060;19696796;19696798;19713939;19732400;19776351;19809571;19853559;19910923;20033059;20059951;20211604;20230749;20231386;20351096;20428113;20448150;20496116;20708039;20826345;20946875;20947020;21102408;2115402;21187331;21278753;21316588;21445324;21482805;21499258;21613550;21620353;21779028;21841790;21883765;21927000;21927001;21962517;21995445;22099461;22101459;22118466;22233676;22357968;22484487;22505844;2257624;22645359;22704991;22815487;22863004;22942912;23186163;23297414;23481700;23536704;23823722;23861397;23891661;24130457;24186068;24366607;24384571;24581490;24680432;24746795;24789820;24966051;25107275;25303366;25341920;25502872;25576301;26042225;26403691;26829388;26975582;26992070;28171750;28218747;2874131;28832583;28834231;2890644;29242379;29314611;29437277;29493099;29557506;30192525;30410026;30429286;30444036;31222486;3128543;31844290;31848261;32157095;32161166;32350084;32387766;32502341;3267234;32897882;32938616;32983136;33592498;33672612;33912179;33968037;34171305;3417785;34357683;34433824;34509645;35051231;35251023;35318648;35580925;36284347;37938771;6146630;7569928;7822302;7877694;8374173;8524399;8552632;8553074;8670264;8837779;9092476;9100026;9169477;9303539;9427626;9428629;9635431;9723620;9733768;9736607;9812899",
        "class_list": "",
        "function": "CLCb/Dyn1-dependent adaptive clathrin-mediated endocytosis selectively altered EGF receptor trafficking., [RefSeq, PubMed]; Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]., [RefSeq]; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data indicate that clathrin-mediated endocytosis of proto-oncogene protein erbB-3 (ErbB3) is depending on epsin-1., [RefSeq, PubMed]; Role of Clathrin Light Chains in Regulating Invadopodia Formation. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53Y37;Q6FHW1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005198 structural molecule activity;GO:0042277 peptide binding;GO:0032050 clathrin heavy chain binding",
        "go_cellular_component": "GO:0030118 clathrin coat;GO:0030125 clathrin vesicle coat;GO:0098835 presynaptic endocytic zone membrane;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006886 intracellular protein transport;GO:0072583 clathrin-dependent endocytosis;GO:0048488 synaptic vesicle endocytosis;GO:0016192 vesicle-mediated transport",
        "synthesized_glycan_count": 0,
        "hit_score": 28.8,
        "record_id": "P09497-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0C854-1",
        "uniprot_id": "CECR9_HUMAN",
        "mass": 23602.0,
        "length": 216,
        "protein_name": "Putative cat eye syndrome critical region protein 9",
        "gene_name": "CECR9",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "CECR9",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative cat eye syndrome critical region protein 9",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "11381032",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "P0C854-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0DN87-1",
        "uniprot_id": "CGB7_HUMAN",
        "mass": 17757.0,
        "length": 165,
        "protein_name": "Choriogonadotropin subunit beta 7",
        "gene_name": "CGB7",
        "organism": "Human",
        "refseq_name": "choriogonadotropin subunit beta 7 precursor",
        "refseq_ac": "NP_149133",
        "gene_names_uniprotkb": "CGB7",
        "gene_names_refseq": "CG-beta-a; CGB6; CGB7",
        "protein_names_uniprotkb": "Choriogonadotropin subunit beta 7",
        "protein_names_refseq": "choriogonadotropin subunit beta 7 precursor; choriogonadotropin subunit beta 7; chorionic gonadotropin beta 7 subunit; chorionic gonadotropin beta subunit 7; chorionic gonadotropin, beta polypeptide 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:94027)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "11861891;16123088;22032922;32767150",
        "class_list": "",
        "function": "Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role for pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy., [UniProtKB]; Expression of the CGB7 gene is upregulated upon p53 induction in human HFF, HCT116 and DLD1 cells as well as in cell preparations enriched in human primary first-trimester trophoblasts., [RefSeq, PubMed]; N- and O-glycosylation patterns and functional testing of CGB7 versus CGB3/5/8 variants of the human chorionic gonadotropin (hCG) beta subunit., [RefSeq, PubMed]; This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 7 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 4,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1A5E0;B9ZVP5;P01233;Q13991;Q14000;Q3KPI3;Q3SY41;Q8WTT5;Q8WXL1;Q8WXL2;Q8WXL3;Q8WXL4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005179 hormone activity",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007267 cell-cell signaling;GO:0006915 apoptotic process;GO:0007292 female gamete generation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "P0DN87-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P16619-1",
        "uniprot_id": "CL3L1_HUMAN",
        "mass": 10161.0,
        "length": 93,
        "protein_name": "C-C motif chemokine 3-like 1",
        "gene_name": "CCL3L1; CCL3L3",
        "organism": "Human",
        "refseq_name": "C-C motif chemokine 3-like 1 precursor",
        "refseq_ac": "NP_001001437",
        "gene_names_uniprotkb": "CCL3L1; CCL3L3; D17S1718; G0S19-2; SCYA3L1",
        "gene_names_refseq": "464.2; CCL3L3; D17S1718; G0S19-2; LD78BETA; LD78; SCYA3L1; SCYA3L",
        "protein_names_uniprotkb": "C-C motif chemokine 3-like 1; G0/G1 switch regulatory protein 19-2; LD78-beta(1-70); PAT 464.2; Small-inducible cytokine A3-like 1; Tonsillar lymphocyte LD78 beta protein",
        "protein_names_refseq": "C-C motif chemokine 3-like 1 precursor; G0/G1 switch regulatory protein 19-2; LD78-beta(1-70); chemokine (C-C motif) ligand 3-like 3; chemokine (C-C motif) ligand 3-like, centromeric; small inducible cytokine A3-like 1; tonsillar lymphocyte LD78 beta protein",
        "tax_id": 9606,
        "disease": "renal fibrosis (Disease Ontology:DOID:0050855); nephritis (Disease Ontology:DOID:10952); Chagas disease (Disease Ontology:DOID:12140); crescentic glomerulonephritis (Disease Ontology:DOID:13139); anterior uveitis (Disease Ontology:DOID:1407); status epilepticus (Disease Ontology:DOID:1824); colon cancer (Disease Ontology:DOID:219); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526)",
        "pathway": " (hsa:414062);  (hsa:6349);  (R-HSA-380108);  (R-HSA-6783783)",
        "pathway_count": 4,
        "publication_count": 109,
        "publication_id_list": "10092818;10229797;10415057;10433356;10640743;10706668;10725696;10725697;10781587;10961862;11060282;11449371;12149255;12554737;12554859;12626585;12832402;12884299;1460289;15067078;15340161;15728180;15919823;16107333;1694014;16982608;17330138;1744577;1840701;1891716;1940369;1940799;1972563;20002784;20145033;2078213;21850230;2217207;2271120;2423119;24743777;29242379;29437277;2970963;3098319;32157095;32350084;32502341;3260265;32983136;33043033;33141586;33936100;34211107;34932366;35051231;35251023;7510216;7512027;7512451;7516408;7543512;7593617;7594602;7602097;7622448;7642634;7679328;7684412;7687627;7851893;7875320;7902377;8048929;8063757;8102388;8120391;8163946;8186324;8301137;8383238;8537680;8639485;8662928;8734788;8742066;8849694;8871669;8897595;8910398;8921438;8946277;9013939;9024663;9164944;9166430;9169459;9207005;9276730;9312047;9354687;9390561;9449724;9463416;9550426;9618518;9794440;9836587;9918218",
        "class_list": "",
        "function": "Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5., [UniProtKB, PubMed, PubMed]; Severe periodontal tissue destruction in Papillon-Lefevre syndrome may be related to excess accumulation of LD78beta and LD78alpha and dysregulation of the microbial-induced inflammatory response in the periodontium, [RefSeq, PubMed]; This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 8,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NGK6;B2RUX4;Q3B7A8;Q53YA5;Q96I68",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0008285 negative regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 11.0,
        "record_id": "P16619-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P33552-1",
        "uniprot_id": "CKS2_HUMAN",
        "mass": 9860.0,
        "length": 79,
        "protein_name": "Cyclin-dependent kinases regulatory subunit 2",
        "gene_name": "CKS2",
        "organism": "Human",
        "refseq_name": "cyclin-dependent kinases regulatory subunit 2",
        "refseq_ac": "NP_001818",
        "gene_names_uniprotkb": "CKS2",
        "gene_names_refseq": "CKS2; CKSHS2",
        "protein_names_uniprotkb": "Cyclin-dependent kinases regulatory subunit 2; CKS-2",
        "protein_names_refseq": "CDC28 protein kinase 2; CKS-2; CKS1(S. cerevisiae Cdc28/Cdc2 kinase subunit) homolog-2; cyclin-dependent kinases regulatory subunit 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:1164)",
        "pathway_count": 1,
        "publication_count": 94,
        "publication_id_list": "10958351;11466336;11557759;15944288;16112985;19608861;19901323;2227411;22869377;23481700;24397554;24714562;24715725;25418920;25576301;25645385;25880248;25892735;26154972;26375851;26811146;26992070;27397612;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28514659;28649982;28832583;28834231;28904123;29242379;29331515;29493099;29508533;29557506;29632046;29769354;29786170;29789417;29930882;30192525;30315122;30429286;30524438;30779550;31154438;31222486;31844290;31848261;31937595;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32897882;32983136;33141586;33298915;33537174;33592498;33691108;33717175;33912179;33936100;33981976;34078123;34087483;34171305;34211107;34932366;35051231;35318648;35561310;35580925;35899496;35903032;36010686;36241641;36284347;36284444;36581221;37938771;38296306;8211159;8265661;9029102",
        "class_list": "",
        "function": "Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function., [UniProtKB]; CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]., [RefSeq]; Cyclin-Dependent Kinase Subunit 2 (CKS2) as a Prognostic Marker for Stages I-III Invasive Non-Mucinous Lung Adenocarcinoma and Its Role in Affecting Drug Sensitivity. Publication Status: Online-Only, [RefSeq, PubMed]; Cyclin-dependent kinase subunit2 (CKS2) promotes malignant phenotypes and epithelial-mesenchymal transition-like process in glioma by activating TGFbeta/SMAD signaling., [RefSeq, PubMed]; Errate: Identification of NDRG Family Member 4 (NDRG4) and CDC28 Protein Kinase Regulatory Subunit 2 (CKS2) as Key Prognostic Genes in Adrenocortical Carcinoma by Transcriptomic Analysis. Correction to:[Med Sci Monit. 2021 Mar 05;27:e928523. doi: 10.12659/MSM.928523. PMID: 33667214] Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown of replication protein A 3 induces protective autophagy and enhances cisplatin sensitivity in lung adenocarcinoma by inhibiting AKT/mTOR signaling via binding to cyclin-dependent kinases regulatory subunit 2., [RefSeq, PubMed]; Prognostic significance of cyclin-dependent kinase subunit 2 (CKS2) in malignant tumours: a meta-analysis and bioinformatic analysis. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6FGI9;Q6LET5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0019901 protein kinase binding;GO:0042393 histone binding;GO:0043130 ubiquitin binding;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity",
        "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex;GO:0000307 cyclin-dependent protein kinase holoenzyme complex",
        "go_biological_process": "GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 9.5,
        "record_id": "P33552-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P49450-1",
        "uniprot_id": "CENPA_HUMAN",
        "mass": 15991.0,
        "length": 140,
        "protein_name": "Histone H3-like centromeric protein A",
        "gene_name": "CENPA",
        "organism": "Human",
        "refseq_name": "histone H3-like centromeric protein A isoform b",
        "refseq_ac": "NP_001035891",
        "gene_names_uniprotkb": "CENPA",
        "gene_names_refseq": "CENP-A; CENPA; CenH3",
        "protein_names_uniprotkb": "Histone H3-like centromeric protein A; CENP-A; Centromere autoantigen A; Centromere protein A",
        "protein_names_refseq": "centromere autoantigen A; centromere protein A, 17kDa; centromere-specific histone; histone H3-like centromeric protein A isoform b; histone H3-like centromeric protein A",
        "tax_id": 9606,
        "disease": "male infertility (Disease Ontology:DOID:12336); oligospermia (Disease Ontology:DOID:14228); cancer (Disease Ontology:DOID:162); autoimmune disease (Disease Ontology:DOID:417); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:1058);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-5663220);  (R-HSA-606279);  (R-HSA-68877);  (R-HSA-9648025)",
        "pathway_count": 9,
        "publication_count": 165,
        "publication_id_list": "10411507;10600384;10678165;10759786;10958683;11053442;11081627;11181178;11237011;11371342;11509732;11535616;11756469;11804586;11862315;12006501;12124871;12194817;12429848;12577064;12679384;12732141;12805219;12852857;14667408;14730319;15006353;15085137;15282608;15339662;15369671;15475964;15507212;15592459;15702419;15723797;15737063;15864301;15866170;15944396;16292343;16439214;16541025;16622419;16622420;16682347;16890222;16943183;17030981;17081983;17112726;17113138;17129783;17196341;17198702;17199038;17210244;17339379;1737036;17651496;18001770;18072184;18097444;18239465;18669648;18716626;18923426;19114591;19350017;19398759;19410544;19410545;19412974;19503796;19533040;19543270;19651622;19696148;19714251;19815554;19965387;20030946;20080577;20101212;20566683;20591975;20630806;20643881;20739937;21111234;21148482;21397845;21406692;21478274;21576392;21743476;21768289;21868368;21878504;21987589;22094460;22275430;22608513;22706990;22790947;22885700;23186163;23222643;23481700;23801653;23818633;23890477;24275569;24522885;24914801;24917673;25408271;25556658;25740311;25789526;25888644;26543159;26878239;26992070;27499292;27600516;28073008;28228285;29760389;30315122;30635586;30892990;31409757;31844290;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;33298915;33691108;33912179;33936100;33968037;34087483;34171305;34260926;34405274;34509645;35494241;36241641;38382691;38566554;38873820;39135477;39305902;39894887;7962047;9024683;9649308;9649503;9892021",
        "class_list": "",
        "function": "Beta-TrCP-Mediated Proteolysis of Mis18beta Prevents Mislocalization of CENP-A and Chromosomal Instability., [RefSeq, PubMed]; CENPA promotes glutamine metabolism and tumor progression by up-regulating SLC38A1 in endometrial cancer., [RefSeq, PubMed]; Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]., [RefSeq]; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:11756469, PubMed:14667408, PubMed:15282608, PubMed:15475964, PubMed:15702419, PubMed:17651496, PubMed:19114591, PubMed:20739937, PubMed:27499292, PubMed:7962047, PubMed:9024683). Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:26878239, PubMed:27499292). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15282608, PubMed:15475964, PubMed:20739937, PubMed:21478274, PubMed:26878239). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; M[6]A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells., [RefSeq, PubMed]; Target Identification and Mechanistic Characterization of Indole Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential for Cdh1-Mediated Proteolysis of CENP-A., [RefSeq, PubMed]; YTHDC1-dependent m6A modification modulated FOXM1 promotes glycolysis and tumor progression through CENPA in triple-negative breast cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D6W544;Q53T74;Q9BVW2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000775 chromosome, centromeric region;GO:0000776 kinetochore",
        "go_biological_process": "GO:0051382 kinetochore assembly;GO:0071459 protein localization to chromosome, centromeric region;GO:0000281 mitotic cytokinesis;GO:0007080 mitotic metaphase chromosome alignment;GO:0000132 establishment of mitotic spindle orientation",
        "synthesized_glycan_count": 0,
        "hit_score": 16.8,
        "record_id": "P49450-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P05787-1",
        "uniprot_id": "K2C8_HUMAN",
        "mass": 53704.0,
        "length": 483,
        "protein_name": "Keratin, type II cytoskeletal 8",
        "gene_name": "KRT8",
        "organism": "Human",
        "refseq_name": "keratin, type II cytoskeletal 8 isoform 2",
        "refseq_ac": "NP_001243222",
        "gene_names_uniprotkb": "KRT8; CYK8",
        "gene_names_refseq": "CARD2; CK-8; CK8; CYK8; K2C8; K8; KO; KRT8",
        "protein_names_uniprotkb": "Keratin, type II cytoskeletal 8; CK-8; Cytokeratin-8; K8; Keratin-8; Type-II keratin Kb8",
        "protein_names_refseq": "cytokeratin-8; keratin 8, type II; keratin, type II cytoskeletal 8 isoform 2; keratin, type II cytoskeletal 8; type-II keratin Kb8",
        "tax_id": 9606,
        "disease": "liver cirrhosis (Disease Ontology:DOID:5082)",
        "pathway": " (hsa:3856);  (R-HSA-6805567);  (R-HSA-6809371);  (R-HSA-9927418);  (R-HSA-9927426)",
        "pathway_count": 5,
        "publication_count": 187,
        "publication_id_list": "10.1101/2023.09.13.557529;10066784;10196183;10231017;10411887;10588656;10771479;10809736;10852826;10973561;11237011;11350120;11380615;11590230;11781324;11788583;12724528;12902340;1371281;1374067;15033990;15337775;15373777;15731013;15797384;15803139;15846844;15972820;16000376;16061697;16083285;16382671;16565220;16608857;16639001;1691124;1691188;1692965;1694855;16964243;17039343;1705144;17074750;17081983;1714783;17515931;17521629;17562024;17596512;17924679;18083107;18212344;18452278;18669648;18691976;18767875;18843291;19007248;19188445;19190773;19194479;19369195;19415658;19608861;19615748;19651622;19664994;19664995;20068230;20068231;20112406;20166139;20179351;20657595;20667819;20729549;20940292;21149639;21158410;21406692;21439340;21654840;21908771;21997417;22121020;22344252;22967762;23186163;23358244;23481192;23629652;24129315;2414304;24275569;2434381;2471065;24940650;25114211;25208914;25218447;25418920;25926655;26390218;26552660;26768311;26823019;26853435;26992070;27397612;27862975;28228285;28834231;28904123;29393594;29557506;29632711;29741879;29786170;29789417;29930882;30059200;30192525;30451992;30484775;30524438;30620550;30779550;31217245;31373491;31611695;31844290;32022439;32157095;32161166;32350084;32373127;32387766;32488085;32502341;32574038;32632966;32897882;32938616;33123756;33214551;33298915;33912179;33968037;33981976;34019948;34087483;34171305;34357683;34509645;34846842;35051231;35083852;35132862;35289036;35494241;35561310;35580925;35958278;36010968;36045259;36215666;36241641;37938771;37995908;38665916;38922788;39531497;39534244;40596516;41018975;41350704;7543090;8660345;8824274;8999895;9054461;9150948;9211903;9395522;9468612;9524113;9565599",
        "class_list": "",
        "function": "A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome., [RefSeq, PubMed]; Keratin 8 Is an Inflammation-Induced and Prognosis-Related Marker for Pancreatic Adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Keratin 8 is a scaffolding and regulatory protein of ERAD complexes., [RefSeq, PubMed]; NAT10 Promotes Prostate Cancer Growth and Metastasis by Acetylating mRNAs of HMGA1 and KRT8., [RefSeq, PubMed]; Required for the formation of KRT8/KRT18 filaments that are involved in ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement. Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Structural component of intermediate filaments in simple epithelial cells. Together with its obligate type I partner KRT18, contributes to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to epithelial cells (PubMed:26823019). Also involved in maintaining epithelial integrity and protecting cells from non-mechanical stress, such as apoptosis (By similarity). Also required for ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement (PubMed:26823019). In striated muscle, together with KRT19, may contribute to linking the contractile apparatus to dystrophin at the costameres (PubMed:16000376)., [UniProtKB, UniProtKB, PubMed, PubMed]; This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 27,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 27,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 27,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 70,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 48,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 1,
        "glyco_site_count": 28,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K4H3;B0AZN5;F8VXB4;Q14099;Q14716;Q14717;Q53GJ0;Q6DHW5;Q6GMY0;Q6P4C7;Q96J60",
        "ec_number_list": "",
        "go_molecular_function": "GO:0097110 scaffold protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005911 cell-cell junction",
        "go_biological_process": "GO:0045214 sarcomere organization",
        "synthesized_glycan_count": 0,
        "hit_score": 22.1,
        "record_id": "P05787-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60333-1",
        "uniprot_id": "KIF1B_HUMAN",
        "mass": 204476.0,
        "length": 1816,
        "protein_name": "Kinesin-like protein KIF1B",
        "gene_name": "KIF1B",
        "organism": "Human",
        "refseq_name": "kinesin-like protein KIF1B isoform b",
        "refseq_ac": "NP_055889",
        "gene_names_uniprotkb": "KIF1B; KIAA0591; KIAA1448",
        "gene_names_refseq": "CMT2A1; CMT2A; CMT2; HMSNII; KIF1B; KLP; NBLST1",
        "protein_names_uniprotkb": "Kinesin-like protein KIF1B; 5.6.1.3; Klp",
        "protein_names_refseq": "Charcot-Marie-Tooth neuropathy type II; kinesin superfamily protein KIF1B; kinesin-like protein KIF1B isoform b; kinesin-like protein KIF1B",
        "tax_id": 9606,
        "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); synucleinopathy (Disease Ontology:DOID:0050890); Charcot-Marie-Tooth disease type 2A1 (Disease Ontology:DOID:0110154); ovary epithelial cancer (Disease Ontology:DOID:2152); multiple sclerosis (Disease Ontology:DOID:2377); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); hepatocellular carcinoma (Disease Ontology:DOID:684); neuroblastoma (Disease Ontology:DOID:769); nervous system disease (Disease Ontology:DOID:863); neuroblastoma, susceptibility to, 1 (MONDO:MONDO:0009741)",
        "pathway": " (hsa:23095);  (R-HSA-6811434);  (R-HSA-983189)",
        "pathway_count": 3,
        "publication_count": 184,
        "publication_id_list": "10052452;10318838;10445031;10559959;10761932;10762626;10921873;11172815;11237011;11389829;11493604;11526494;11689559;11703931;11726511;11739780;11748249;11782313;12047556;12070132;12368902;12888911;1406973;14504276;14654841;15029241;15037235;15272311;15326200;15616190;15632110;15813748;16030262;1607388;16225668;16262723;1631136;16571679;16633337;1680566;16912714;16926190;16940185;17113389;17253781;17346968;17360540;17429068;17451557;17538014;17760859;17927562;17956946;18182008;18287528;18334619;18342609;18524849;18669648;18726616;18809720;1898986;19015319;19109418;19116309;19151722;19164740;19338388;19369418;1957170;19631211;19690332;19758564;20005805;20068231;20136777;20357002;20427317;20462495;20534429;20637885;21219331;2142332;21550981;21689688;21844168;22013193;22094269;22304919;23186163;23396477;23481700;24275569;24366607;24714562;2521221;2522352;25364732;25436559;25492864;25576301;25645385;26768311;26811146;27600516;27846572;27862975;27920218;28514659;28649982;28832583;28834231;28871256;28904123;29242379;29393594;29557506;29769354;29786170;30059200;30315122;30379171;30410026;30779550;31154438;31217245;3130248;3134048;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32897882;32938616;32983136;33112832;33141586;33298915;33537174;33592498;33912179;33968037;33981976;34087483;34112167;34171305;34185709;34509645;34561969;35051231;35561310;35580925;36010968;36241641;36284347;37217939;37938771;39302247;7528108;7539720;7822426;7844144;7929562;8001155;8128252;8132710;8221884;8253837;8505331;8548803;8599929;8602245;8620540;9114004;9177194;9244307;9288971;9405360;9751720;9990005",
        "class_list": "",
        "function": "Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619)., [UniProtKB, UniProtKB, PubMed]; Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria., [UniProtKB, PubMed]; Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules., [UniProtKB, PubMed]; USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bbeta via deubiquitinating EGLN3. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 49,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 10,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NFS8;A6NKQ4;Q4VXC3;Q4VXC4;Q4VXC5;Q4VXC6;Q96Q94;Q9BV80;Q9P280",
        "ec_number_list": "3.6.5.-;5.6.1.3;3.6.5.2;3.6.4.-",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0019894 kinesin binding;GO:0008574 plus-end-directed microtubule motor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005874 microtubule;GO:0030424 axon;GO:0030425 dendrite",
        "go_biological_process": "GO:0047497 mitochondrion transport along microtubule;GO:0007274 neuromuscular synaptic transmission;GO:0006915 apoptotic process;GO:0016192 vesicle-mediated transport;GO:0048490 anterograde synaptic vesicle transport",
        "synthesized_glycan_count": 0,
        "hit_score": 18.9,
        "record_id": "O60333-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P05813-1",
        "uniprot_id": "CRBA1_HUMAN",
        "mass": 25150.0,
        "length": 215,
        "protein_name": "Beta-crystallin A3",
        "gene_name": "CRYBA1",
        "organism": "Human",
        "refseq_name": "beta-crystallin A3",
        "refseq_ac": "NP_005199",
        "gene_names_uniprotkb": "CRYBA1; CRYB1",
        "gene_names_refseq": "CRYB1; CRYBA1; CTRCT10",
        "protein_names_uniprotkb": "Beta-crystallin A3",
        "protein_names_refseq": "beta crystallin A3 chain transcript CN; beta crystallin A3 chain transcript LAM; beta crystallin A3 chain transcript PS; beta crystallin A3 chain transcript TC; beta-crystallin A3; crystallin beta A3/A1; crystallin, beta A3; eye lens structural protein",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); age related macular degeneration 1 (Disease Ontology:DOID:0110014); cataract 10 multiple types (Disease Ontology:DOID:0110258); microphthalmia (Disease Ontology:DOID:10629); morbid obesity (Disease Ontology:DOID:11981); atherosclerosis (Disease Ontology:DOID:1936); glioblastoma (Disease Ontology:DOID:3068); coronary artery disease (Disease Ontology:DOID:3393); retinal detachment (Disease Ontology:DOID:5327); cataract (Disease Ontology:DOID:83); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:1411)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;12060738;15016766;15576560;21866213;28083894;31488069;31523120;33827296;34419537;34489339;3745196;8999933;9788845",
        "class_list": "",
        "function": "A novel missense mutation of CRYBA1 in a northern Chinese family with inherited coronary cataract with blue punctate opacities., [RefSeq, PubMed]; CRYBA1 showed lower expression in cataract lenses than in control lenses. The deleted form (p.G91del) of CRYBA1 showed lower expression and was more aggregate to the cell membrane than the wild-type CRYBA1. Publication Status: Online-Only, [RefSeq, PubMed]; Cataract-causing G91del mutant destabilised betaA3 heteromers formation linking with structural stability and cellular viability., [RefSeq, PubMed]; Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, encodes two proteins (crystallin, beta A3 and crystallin, beta A1) from a single mRNA, the latter protein is 17 aa shorter than crystallin, beta A3 and is generated by use of an alternate translation initiation site. Deletion of exons 3 and 4 causes the autosomal dominant disease 'zonular cataract with sutural opacities'. [provided by RefSeq, Jul 2008]., [RefSeq]; Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB]; Pathogenic mechanism of congenital cataract caused by the CRYBA1/A3-G91del variant and related intervention strategies., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 14,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q13633;Q14CM9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005212 structural constituent of eye lens",
        "go_cellular_component": "",
        "go_biological_process": "GO:0010506 regulation of autophagy;GO:0006909 phagocytosis;GO:0007601 visual perception;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0032007 negative regulation of TOR signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "P05813-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00255-2",
        "uniprot_id": "MEN1_HUMAN",
        "mass": 67497.0,
        "length": 610,
        "protein_name": "Menin",
        "gene_name": "MEN1",
        "organism": "Human",
        "refseq_name": "menin isoform 2",
        "refseq_ac": "NP_001357188",
        "gene_names_uniprotkb": "MEN1; SCG2",
        "gene_names_refseq": "MEAI; MEN1; SCG2",
        "protein_names_uniprotkb": "Menin",
        "protein_names_refseq": "menin isoform 2",
        "tax_id": 9606,
        "disease": "multiple endocrine neoplasia type 1 (Disease Ontology:DOID:10017); hyperparathyroidism (Disease Ontology:DOID:13543); congenital heart disease (Disease Ontology:DOID:1682); pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); prolactinoma (Disease Ontology:DOID:5394); gastrinoma (Disease Ontology:DOID:5577); growth hormone secreting pituitary adenoma (Disease Ontology:DOID:6255); duodenal gastrinoma (Disease Ontology:DOID:7959)",
        "pathway": " (hsa:4221);  (R-HSA-201722);  (R-HSA-2173796);  (R-HSA-3769402);  (R-HSA-381426);  (R-HSA-5626467);  (R-HSA-8957275);  (R-HSA-9772755);  (R-HSA-9976102)",
        "pathway_count": 9,
        "publication_count": 343,
        "publication_id_list": "10.1101/2023.09.13.557529;10022445;10022869;10026136;10077652;10080941;10090472;10199400;10218588;10229909;10473551;10485845;10512690;10534569;10549281;10576763;10614670;10617276;10634381;10647896;10660339;10664520;10664521;10681634;10715991;10769018;10775268;10810289;10831834;10849016;10870030;10898789;10898936;10912521;10921920;10944533;10951195;10990447;10993647;11007770;11013220;11034102;11050151;11080158;11102994;11134142;11136974;11158056;11241849;11250653;11264294;11274402;11316783;11424093;11427533;11522292;11526476;11532957;11606061;11691915;11713476;11739083;11751371;11788658;11934263;11948177;11955446;11973335;11988739;12016470;12050235;12110184;12112656;12150994;12163411;12241545;12379487;12393701;12408824;12408825;12417605;12446674;12466191;12482972;12652570;12670868;12699448;12712206;12746426;12791038;12810533;12837246;12874027;12904166;12917425;1370451;1383255;14600025;14636557;14657019;14685266;14686752;14695187;14992727;15060161;15100235;15121853;15126567;15132997;15150273;15199122;15205994;15294866;15308688;15327769;15374998;15469690;15485880;15525529;15525596;15642270;15714081;15730416;15754732;15768032;15829968;16005293;16169192;16227571;16239140;16278212;16319104;16510874;16630820;16756492;16829959;16878130;16892064;17047378;17052462;17218525;17244649;17249697;17312271;17355966;17412698;17425782;17428831;17438144;17458864;17500065;17525332;17555499;17555500;17612494;17671196;17698607;17875931;17925232;17985932;17998332;18077418;18160138;18160704;18237546;18347063;18378692;18404694;18456656;18498752;18568018;18573912;18598779;18598942;18669648;18819930;18829457;18829459;18838386;18838538;18991276;19047045;19079338;19103755;19124460;19148484;19187761;19364920;19413330;19460168;19487454;19493659;19556245;19571879;19590513;19664995;19737400;19914168;19928349;19940019;20018852;20068231;20575550;20595680;20716525;20961854;21106533;21124902;21131905;21135039;21220120;21299499;21654818;21726809;21730051;22186018;22190459;22266653;22275377;22304967;22327296;22617422;22652693;22665483;22936661;22944912;22982193;23186163;23508102;23995757;24244196;24275569;24291232;24368734;24680668;2476804;2479552;25305204;25418920;25561738;25593305;25645385;25892735;26091039;26324722;26768311;26886794;27563068;27698142;27760318;27920218;28063628;28182322;28228285;28398509;28514659;28832583;29138278;29242379;29393594;29632046;29632711;29769354;29786170;29897600;29937342;30315122;30779550;30792230;30833945;31400120;31485071;31530632;31544921;31848261;31936902;31998317;33657400;34012049;34933446;35033534;35190547;35439434;37867522;37938771;38003662;38609433;38968834;39041891;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7683646;7689487;8756646;8756721;8757136;8781553;8798539;8817670;8894645;8955148;8964575;9103196;9118222;9199170;9215689;9215690;9241276;9368021;9463336;9488439;9490669;9497324;9506756;9671267;9683585;9694656;9709921;9709957;9709976;9709985;9733769;9740255;9747036;9751710;9786878;9792884;9819412;9820618;9832038;9843042;9843967;9888389;9922210;9935177;9989505",
        "class_list": "",
        "function": "Combined deletion of MEN1, ATRX and PTEN triggers development of high-grade pancreatic neuroendocrine tumors in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Dependency of B-Cell Acute Lymphoblastic Leukemia and Multiple Myeloma Cell Lines on MEN1 Extends beyond MEN1-KMT2A Interaction. Publication Status: Online-Only, [RefSeq, PubMed]; Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; MEN1 Deficiency-Driven Activation of the beta-Catenin-MGMT Axis Promotes Pancreatic Neuroendocrine Tumor Growth and Confers Temozolomide Resistance., [RefSeq, PubMed]; Menin signaling and therapeutic targeting in breast cancer. Review article, [RefSeq, PubMed]; Multiple endocrine neoplasia type 1 with Zollinger-Ellison syndrome: clinicopathological analysis of a Japanese family with focus on menin immunohistochemistry. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones. [provided by RefSeq, May 2019]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 9,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5HBC6;A5HBC7;A5HBC8;A5HBC9;A5HBD0;A5HBD1;A5HBD2;O00632;Q9BUF0;Q9BUK2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051219 phosphoprotein binding;GO:0003690 double-stranded DNA binding;GO:0000976 transcription cis-regulatory region binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005788 endoplasmic reticulum lumen;GO:0005829 cytosol",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0010332 response to gamma radiation",
        "synthesized_glycan_count": 0,
        "hit_score": 34.6,
        "record_id": "O00255-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P26639-1",
        "uniprot_id": "SYTC_HUMAN",
        "mass": 83435.0,
        "length": 723,
        "protein_name": "Threonine--tRNA ligase 1, cytoplasmic",
        "gene_name": "TARS1",
        "organism": "Human",
        "refseq_name": "threonine--tRNA ligase 1, cytoplasmic isoform 1",
        "refseq_ac": "NP_001245366",
        "gene_names_uniprotkb": "TARS1; TARS",
        "gene_names_refseq": "TARS1; TARS; TTD7; ThrRS",
        "protein_names_uniprotkb": "Threonine--tRNA ligase 1, cytoplasmic; 6.1.1.3; ThrRS; Threonyl-tRNA synthetase 1; Threonyl-tRNA synthetase",
        "protein_names_refseq": "threonine tRNA ligase 1, cytoplasmic; threonine--tRNA ligase 1, cytoplasmic isoform 1; threonine--tRNA ligase, cytoplasmic; threonyl-tRNA synthetase, cytoplasmic",
        "tax_id": 9606,
        "disease": "nonphotosensitive trichothiodystrophy (Disease Ontology:DOID:0111867); nonphotosensitive trichothiodystrophy 7 (Disease Ontology:DOID:0111870); amino acid metabolic disorder (Disease Ontology:DOID:9252)",
        "pathway": " (hsa:6897);  (R-HSA-379716)",
        "pathway_count": 2,
        "publication_count": 143,
        "publication_id_list": "11237011;11347887;11714285;11829477;11858721;12690580;1373391;14660560;14671330;14978097;16055448;16139798;16408927;16429158;16906134;1761529;18083107;18512783;19608861;20068231;2033077;22424782;22544926;23186163;23301498;23481700;24714562;24715725;24958902;25418920;25576301;25645385;25824639;25892735;26154972;26375851;26758079;26768311;26929215;26992070;27600516;27846572;27862975;27920218;28218747;28228285;28467828;28514659;28649982;28832583;28834231;28860189;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29769354;29786170;30315122;30410026;30429286;30484775;30524438;30779550;30833945;31020640;31154438;31217245;31374204;31530632;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32870666;32897882;32938616;32983136;33043033;33141586;33214551;33298915;33537174;33592498;33633747;33691108;33717175;33936100;33968037;33981976;34019948;34087483;34159625;34171305;34211107;34357683;34405274;34509645;34561969;34725712;34932366;35051231;35138101;35154160;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37938771;38665916;38956874;40914422;4130389;6022858;656444;7118399;7654687;8052601;8078941;8188258;8428657;8449960;9278442;9421509;9431993",
        "class_list": "",
        "function": "A model organism pipeline provides insight into the clinical heterogeneity of TARS1 loss-of-function variants., [RefSeq, PubMed]; Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]., [RefSeq]; Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype., [RefSeq, PubMed]; Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Contribution of upregulated aminoacyl-tRNA biosynthesis to metabolic dysregulation in gastric cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K8I1;B4DEG8;Q96FP5;Q9BWA6",
        "ec_number_list": "6.1.1.3",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000049 tRNA binding;GO:0004829 threonine-tRNA ligase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006435 threonyl-tRNA aminoacylation;GO:0006412 translation",
        "synthesized_glycan_count": 0,
        "hit_score": 14.6,
        "record_id": "P26639-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P08861-1",
        "uniprot_id": "CEL3B_HUMAN",
        "mass": 29263.0,
        "length": 270,
        "protein_name": "Chymotrypsin-like elastase family member 3B",
        "gene_name": "CELA3B",
        "organism": "Human",
        "refseq_name": "chymotrypsin-like elastase family member 3B preproprotein",
        "refseq_ac": "NP_031378",
        "gene_names_uniprotkb": "CELA3B; ELA3B",
        "gene_names_refseq": "CBPP; CELA3B; ELA3B",
        "protein_names_uniprotkb": "Chymotrypsin-like elastase family member 3B; 3.4.21.70; Elastase IIIB; Elastase-3B; Protease E",
        "protein_names_refseq": "cholesterol-binding pancreatic protease; chymotrypsin like elastase family member 3B; chymotrypsin-like elastase family member 3B preproprotein; elastase 3B, pancreatic; elastase IIIB; elastase-3B; fecal elastase 1; pancreatic elastase 1; pancreatic endopeptidase E; protease E; proteinase E",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23436);  (R-HSA-9925561)",
        "pathway_count": 2,
        "publication_count": 18,
        "publication_id_list": "10620133;11237011;1898343;2675835;2737288;2753124;2826474;29557506;29632711;30106003;31369399;3178837;32488085;33565216;34087483;3477287;36610873;37307306",
        "class_list": "",
        "function": "Does the Complex of CELA3B Variants With Other Pancreatitis-Related Genes Affect Developing Childhood Pancreatitis?, [RefSeq, PubMed]; Efficient protease with alanine specificity but only little elastolytic activity., [UniProtKB]; Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]., [RefSeq]; The aim of this study was to examine the frequency of exocrine dysfunctions of the pancreas according to the level of fecal elastase-1 (FE-1) in patients with diabetes mellitus, type 1 and diabetes mellitus, type 2., [RefSeq, PubMed]; The reversion variant (p.Arg90Leu) at the evolutionarily adaptive p.Arg90 site in CELA3B predisposes to chronic pancreatitis., [RefSeq, PubMed]; Utility of Fecal Elastase-1 to diagnose severe exocrine insufficiency in chronic pancreatitis: Real world experience., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 15,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 40,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RE44;P11423;Q5VU28;Q5VU29;Q5VU30",
        "ec_number_list": "3.1.1.4;3.2.1.1;3.4.21.35;3.4.21.4;4.6.1.18;3.4.21.71;3.4.21.70;3.4.17.1;3.4.17.2;3.1.1.3;3.1.1.13;3.1.1.6;3.4.21.-;3.4.17.15;3.1.1.26;5.3.4.1;2.1.1.20;3.4.21.2",
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 6.0,
        "record_id": "P08861-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60664-1",
        "uniprot_id": "PLIN3_HUMAN",
        "mass": 47075.0,
        "length": 434,
        "protein_name": "Perilipin-3",
        "gene_name": "PLIN3",
        "organism": "Human",
        "refseq_name": "perilipin-3 isoform 2",
        "refseq_ac": "NP_001157661",
        "gene_names_uniprotkb": "PLIN3; M6PRBP1; TIP47",
        "gene_names_refseq": "M6PRBP1; PLIN3; PP17; TIP47",
        "protein_names_uniprotkb": "Perilipin-3; 47 kDa MPR-binding protein; 47 kDa mannose 6-phosphate receptor-binding protein; Cargo selection protein TIP47; Mannose-6-phosphate receptor-binding protein 1; PP17; Placental protein 17",
        "protein_names_refseq": "47 kDa MPR-binding protein; cargo selection protein TIP47; mannose-6-phosphate receptor-binding protein 1; perilipin-3 isoform 2; placental protein 17; tail-interacting protein, 47 kD; testicular tissue protein Li 114",
        "tax_id": 9606,
        "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:10226);  (R-HSA-163560);  (R-HSA-6811440);  (R-HSA-9613354);  (R-HSA-9613829);  (R-HSA-9615710);  (R-HSA-9706019)",
        "pathway_count": 7,
        "publication_count": 220,
        "publication_id_list": "10209123;10393528;10445031;10559959;10637310;10671541;10865125;10990452;11082038;11237011;11303027;11346801;11359012;11689439;11827983;11839770;12070132;12377769;12620188;12620189;12832420;14580338;14718928;15029241;15037235;15077113;15077114;15128430;15269279;15364929;15456755;15483056;15545278;15654769;15758030;15870108;15878329;16042553;16129887;16571679;16741517;16885419;16912714;16936697;17145369;17451557;17488291;17562788;17603008;17684057;17698061;18195106;18243103;18256213;18367545;18491316;18644871;18664496;18669648;18707149;18767875;18946081;19019082;19164740;19181555;19413330;19490898;19608861;19615748;19620288;20068231;20685960;20797626;21183348;21238931;21282471;21421921;21436057;21504868;21654843;21689688;21807881;2204156;22223895;22245496;22335553;22354037;22581368;22709582;22717455;23091056;23186163;23301498;23437303;23481700;24145166;24714562;24794632;25114211;25343031;25418920;25548167;25576301;25645385;25961502;26118642;26154972;26215701;26357594;26811146;26902588;26992070;27600516;27846572;2799391;28218747;28228285;28467828;28657654;28832583;28834231;28904123;29237092;29242379;29393594;29493099;29508533;29557506;29626215;29786170;30059200;30192525;30315122;30410026;30429286;30524438;30573663;30620550;30833945;31020640;31154438;31217245;31373491;31492838;31530632;31611695;31844290;31848261;31998317;32157095;32161166;32350084;32387766;32488085;32502341;32574038;32897882;32938616;32938750;32983136;33123756;33141586;33298915;33392160;33592498;33691108;33717175;33968037;33981976;34019948;34077757;34229054;34357683;34509645;34725712;34929314;35051231;35132862;35154160;35251023;35254053;35318648;35513511;35561310;35580925;35705054;36010968;36215666;36241641;36284347;37340703;37443287;37578465;37898398;37938771;38253038;38287724;38554152;38665916;39302247;39531497;39534244;40307207;40596516;41350704;6856484;7909812;8221884;8440258;8620540;8636227;8662539;8670882;9038169;9050864;9151685;9177194;9230071;9590177;9874244",
        "class_list": "",
        "function": "Binding of perilipin 3 to membranes containing diacylglycerol is mediated by conserved residues within its PAT domain., [RefSeq, PubMed]; Lipid droplets-related Perilipin-3: potential immune checkpoint and oncogene in oral squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009]., [RefSeq]; Silencing of Perilipin 3 Inhibits Lung Adenocarcinoma Cell Immune Resistance by Regulating the Transcription of PD-L1 Through c-Myc., [RefSeq, PubMed]; Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Tumor-derived Prevotella intermedia aggravates gastric cancer by enhancing Perilipin 3 expression. Erratum:[Cancer Sci. 2025 Apr;116(4):1156. doi: 10.1111/cas.70005. PMID: 39936303], [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 15,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 15,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 15,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 21,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 15,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K4Y9;K7EQF4;Q53G77;Q9BS03;Q9UBD7;Q9UP92",
        "ec_number_list": "",
        "go_molecular_function": "GO:0045296 cadherin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet;GO:0005829 cytosol",
        "go_biological_process": "GO:0042149 cellular response to glucose starvation;GO:0016192 vesicle-mediated transport;GO:0010890 positive regulation of triglyceride storage;GO:0019915 lipid storage;GO:1905691 lipid droplet disassembly",
        "synthesized_glycan_count": 0,
        "hit_score": 23.7,
        "record_id": "O60664-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "B7Z368-1",
        "uniprot_id": "CJ142_HUMAN",
        "mass": 13757.0,
        "length": 130,
        "protein_name": "Uncharacterized protein encoded by LINC02881",
        "gene_name": "LINC02881",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "LINC02881; C10orf142",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Uncharacterized protein encoded by LINC02881; Long intergenic non-protein coding RNA 2881",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "30379171",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "B7Z368-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15554-1",
        "uniprot_id": "KCNN4_HUMAN",
        "mass": 47696.0,
        "length": 427,
        "protein_name": "Intermediate conductance calcium-activated potassium channel protein 4",
        "gene_name": "KCNN4",
        "organism": "Human",
        "refseq_name": "intermediate conductance calcium-activated potassium channel protein 4",
        "refseq_ac": "NP_002241",
        "gene_names_uniprotkb": "KCNN4; IK1; IKCA1; KCA4; SK4",
        "gene_names_refseq": "DHS2; IK1; IKCA1; IK; KCA4; KCNN4; KCa3.1; SK4; SKCa4; hIK1; hIKCa1; hKCa4; hSK4",
        "protein_names_uniprotkb": "Intermediate conductance calcium-activated potassium channel protein 4; Gardos channel; IKCa1; KCa3.1; Putative Gardos channel; SKCa 4; SKCa4; hIK1; hKCa4; hSK4",
        "protein_names_refseq": "gardos channel; intermediate conductance calcium-activated potassium channel protein 4; intermediate-conductance Ca2+-activated K+ channel, KCa3.1; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; putative Gardos channel; putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel; small conductance calcium-activated potassium channel 4",
        "tax_id": 9606,
        "disease": "angiosarcoma (Disease Ontology:DOID:0001816); dehydrated hereditary stomatocytosis 2 (Disease Ontology:DOID:0111577); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); brain edema (Disease Ontology:DOID:4724); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:3783);  (R-HSA-1296052)",
        "pathway_count": 2,
        "publication_count": 53,
        "publication_id_list": "10026195;10961988;11237011;11425865;15243742;15831468;17157250;18796614;19074509;20178789;20859064;22645359;24591580;26148990;26178367;26198474;26418693;26992070;28228285;28467828;28832583;28904123;29242379;29314611;29393594;29724949;29769354;29953543;30315122;31611695;31844290;32350084;32387766;32938616;33141586;33298915;33968037;34357683;34509645;35051231;35154160;36010968;36241641;36580660;37968509;38018635;38134241;38338693;38673845;9326665;9380751;9407042;9693050",
        "class_list": "",
        "function": "A single coiled-coil domain mutation in hIKCa channel subunits disrupts preferential formation of heteromeric hSK1:hIKCa channels., [RefSeq, PubMed]; Intermediate conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:10026195, PubMed:10961988, PubMed:11425865, PubMed:15831468, PubMed:17157250, PubMed:18796614, PubMed:26148990, PubMed:9326665, PubMed:9380751, PubMed:9407042). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 25 picosiemens (PubMed:9326665, PubMed:9380751, PubMed:9407042). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (PubMed:9326665, PubMed:9380751, PubMed:9407042). Controls calcium influx during vascular contractility by being responsible of membrane hyperpolarization induced by vasoactive factors in proliferative vascular smooth muscle cell types (By similarity). Following calcium influx, the consecutive activation of KCNN4 channel leads to a hyperpolarization of the cell membrane potential and hence an increase of the electrical driving force for further calcium influx promoting sustained calcium entry in response to stimulation with chemotactic peptides (PubMed:26418693). Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis through activation by PI(3)P (PubMed:24591580)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Investigating the Impact of Electrostatic Interactions on Calmodulin Binding and Ca[2+]-Dependent Activation of the Calcium-Gated Potassium SK4 Channel. Publication Status: Online-Only, [RefSeq, PubMed]; KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation., [RefSeq, PubMed]; Overexpression of KCNN4 channels in principal neurons produces an anti-seizure effect without reducing their coding ability., [RefSeq, PubMed]; The Gardos Channel and Piezo1 Revisited: Comparison between Reticulocytes and Mature Red Blood Cells. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 10,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53XR4",
        "ec_number_list": "1.8.-.-",
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0042803 protein homodimerization activity;GO:0005267 potassium channel activity;GO:0019903 protein phosphatase binding;GO:0015269 calcium-activated potassium channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043005 neuron projection;GO:0031982 vesicle;GO:0008076 voltage-gated potassium channel complex",
        "go_biological_process": "GO:0030322 stabilization of membrane potential;GO:0006952 defense response;GO:0051289 protein homotetramerization;GO:0006816 calcium ion transport;GO:0050862 positive regulation of T cell receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "O15554-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A8K4G0-1",
        "uniprot_id": "CLM7_HUMAN",
        "mass": 22689.0,
        "length": 201,
        "protein_name": "CMRF35-like molecule 7",
        "gene_name": "CD300LB",
        "organism": "Human",
        "refseq_name": "CMRF35-like molecule 7 precursor",
        "refseq_ac": "NP_777552",
        "gene_names_uniprotkb": "CD300LB; CD300B; CLM7; CMRF35A2; IREM3; LMIR5; PRO6029; TREM5",
        "gene_names_refseq": "CD300LB; CD300b; CLM-7; CLM7; CMRF35-A2; IREM-3; IREM3; TREM-5; TREM5",
        "protein_names_uniprotkb": "CMRF35-like molecule 7; CD300 antigen-like family member B; CLM-7; CMRF35-A2; IREM-3; Immune receptor expressed on myeloid cells 3; Leukocyte mono-Ig-like receptor 5; TREM-5; Triggering receptor expressed on myeloid cells 5",
        "protein_names_refseq": "CD300 antigen like family member B; CMRF35-like molecule 7 precursor; CMRF35-like molecule 7; immune receptor expressed on myeloid cells 3; leukocyte mono-Ig-like receptor 5; triggering receptor expressed on myeloid cells 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:124599);  (R-HSA-198933);  (R-HSA-2172127)",
        "pathway_count": 3,
        "publication_count": 116,
        "publication_id_list": "10049942;10449773;10499918;10604985;10746781;10940905;11237011;11265639;11489943;11513152;11556966;11602640;11807247;11857637;11858820;11861603;11955593;11955595;11955599;12213321;12483297;12588680;12668644;12776204;12975309;14707061;14719373;14970179;15034010;15136729;15155468;15187158;15265913;15304001;15534202;15541655;15557162;15580655;15607800;15778510;15781451;15800062;15851719;15864273;15884055;15940674;16014749;16091383;16129954;16339513;16380601;16551255;16623599;16737824;16754721;16893496;16904340;16920917;16928187;16933987;17012248;17045824;17057721;17110943;17202323;17237375;17337780;17483134;17641029;17928527;18031695;18037897;18055229;18209062;18234675;18593354;18624290;18629938;19149696;19359216;19592130;19858347;20093094;20237496;20730098;20865034;20890284;21241660;21800138;21841309;21877119;22396535;23072861;23695528;23929856;24305946;25703557;25716998;26284469;26300885;27261276;28005267;29242379;32350084;32983136;7531291;7542404;8178173;8995416;9285412;9314561;9490415;9625766;9655483;9700512;9730896",
        "class_list": "",
        "function": "Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2., [UniProtKB, PubMed, PubMed]; Although both mouse and human LMIR5 play activatory roles in innate immunity cells, the functions of LMIR5 were differentially regulated in mouse versus human cells., [RefSeq, PubMed]; CD300 molecules are all expressed by DC; CD300b, d, e and f are restricted to different subpopulations of the myeloid DC lineage. They have been shown to regulate DC function both in vitro and in vivo. Review article, [RefSeq, PubMed]; CD300LB expression is significantly upregulated in human masticatory mucosa during wound healing, [RefSeq, PubMed]; CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells (Martinez-Barriocanal and Sayos, 2006 [PubMed 16920917]).[supplied by OMIM, Mar 2008]., [RefSeq]; CD300b defines a nonclassical Ig receptor able to trigger signals by coupling distinct mediators and thus initiating different signaling pathways, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This paper identified CD300b as an lipopolysaccharide-recognizing receptor that regulated TLR4 signaling, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q1EG73;Q8IX40;Q8N6D1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0002757 immune response-activating signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 11.7,
        "record_id": "A8K4G0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P09917-1",
        "uniprot_id": "LOX5_HUMAN",
        "mass": 77983.0,
        "length": 674,
        "protein_name": "Polyunsaturated fatty acid 5-lipoxygenase",
        "gene_name": "ALOX5",
        "organism": "Human",
        "refseq_name": "polyunsaturated fatty acid 5-lipoxygenase isoform 1",
        "refseq_ac": "NP_000689",
        "gene_names_uniprotkb": "ALOX5; LOG5",
        "gene_names_refseq": "5-LOX; 5-LO; 5LPG; ALOX5; LOG5",
        "protein_names_uniprotkb": "Polyunsaturated fatty acid 5-lipoxygenase; 1.13.11.-; 1.13.11.34; 5-LO; 5-lipoxygenase; Arachidonate 5-lipoxygenase",
        "protein_names_refseq": "LOX-5; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase; polyunsaturated fatty acid 5-lipoxygenase isoform 1; polyunsaturated fatty acid 5-lipoxygenase",
        "tax_id": 9606,
        "disease": "exercise-induced bronchoconstriction (Disease Ontology:DOID:0080821); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); pleurisy (Disease Ontology:DOID:10247); common cold (Disease Ontology:DOID:10459); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); pulmonary edema (Disease Ontology:DOID:11396); nephrotic syndrome (Disease Ontology:DOID:1184); pancreatic cancer (Disease Ontology:DOID:1793); brain ischemia (Disease Ontology:DOID:2316); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); acute kidney failure (Disease Ontology:DOID:3021); pulmonary fibrosis (Disease Ontology:DOID:3770); cholangiocarcinoma (Disease Ontology:DOID:4947); pulmonary hypertension (Disease Ontology:DOID:6432); in situ carcinoma (Disease Ontology:DOID:8719)",
        "pathway": " (hsa:240);  (R-HSA-2142688);  (R-HSA-2142691);  (R-HSA-2142700);  (R-HSA-6785807);  (R-HSA-6798695);  (R-HSA-9012546);  (R-HSA-9018676);  (R-HSA-9018682);  (R-HSA-9018896);  (R-HSA-9020265);  (R-HSA-9023661);  (R-HSA-9026286);  (R-HSA-9026290);  (R-HSA-9026403);  (R-HSA-9027604)",
        "pathway_count": 16,
        "publication_count": 249,
        "publication_id_list": "10023775;10023777;10064732;10219247;10369418;10510379;10549853;10586089;10779545;10837478;10867011;11058569;11084045;11104795;11115402;11120780;11278437;11278729;11356008;11404481;11463377;11844797;11960372;12205041;12223527;12242343;12391014;12600988;12670876;12832402;1359745;14634100;14712222;15116091;15261459;15280375;15308583;1540191;15584925;15604543;15772423;15805299;15869882;15950906;16007214;16048438;16107692;16205632;16230355;16236134;16275640;16397018;16451196;16510571;16540365;16606674;16757471;16795963;17114001;17244615;17427945;17458857;17519235;17572495;18184802;18243101;18292578;18353781;18447642;1848634;18644974;18647347;18978352;18991276;19022417;19082953;19103881;19124156;19185846;19233132;1939225;19397496;19743890;19807693;19865173;20436486;20436887;20493732;21098726;21102457;21200133;21206090;21233389;21252155;21447318;2155925;21689689;21730069;21937440;21994466;22046235;22205702;22275352;22383755;22450811;2251250;22516296;22693070;22851691;23076889;23086340;23124025;23172665;23246375;23293324;23438748;23455323;23481700;23555662;23650620;23736886;23967200;24097101;24282679;24576195;24736647;24743777;24860872;24893149;25036362;25234944;2526519;2565035;26210919;26236990;26743932;26992070;27046942;2753893;2768222;27704804;27846572;27862975;27920218;28218747;28228285;2829172;2836406;28408222;2864155;2866075;2877850;2882965;28832583;28834231;28904123;28980694;29133059;29242379;29314611;29331515;29437277;29508533;29557506;29632711;29786170;2995393;3006030;3020588;30315122;30410026;30429286;30669;3118366;3164719;31664810;31844290;31848261;32157095;32350084;32357974;32387766;32404334;32502341;32841762;32983136;33123756;33298915;33691108;33717175;33912179;3422434;34932366;35051231;35318648;35580925;3563417;3579953;36241641;36284347;3770188;37926274;37965796;38172525;38412254;38575760;3933675;6089195;6122208;6293969;6422933;6490615;6816802;7510216;7512451;7529288;7568157;7795521;7796300;7898939;7907877;7929073;7937884;8052639;8085155;8245774;8250832;8394361;8428933;8576264;8602263;8615788;8621622;8631361;8663118;8668165;8692836;8797861;8816495;8847485;9013879;9325300;9461497;9651359;9723655;9736340;9792649;9822675;9874564",
        "class_list": "",
        "function": "ALOX5 drives the pyroptosis of CD4[+] T cells and tissue inflammation in rheumatoid arthritis., [RefSeq, PubMed]; Cancer-educated neutrophils promote lung cancer progression via PARP-1-ALOX5-mediated MMP-9 expression., [RefSeq, PubMed]; Catalyzes the oxygenation of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis of leukotrienes, which are potent mediators of inflammation (PubMed:19022417, PubMed:21233389, PubMed:22516296, PubMed:23246375, PubMed:24282679, PubMed:24893149, PubMed:31664810, PubMed:8615788, PubMed:8631361). Also catalyzes the oxygenation of arachidonate into 8-hydroperoxyicosatetraenoate (8-HPETE) and 12-hydroperoxyicosatetraenoate (12-HPETE) (PubMed:23246375). Displays lipoxin synthase activity being able to convert (15S)-HETE into a conjugate tetraene (PubMed:31664810). Although arachidonate is the preferred substrate, this enzyme can also metabolize oxidized fatty acids derived from arachidonate such as (15S)-HETE, eicosapentaenoate (EPA) such as (18R)- and (18S)-HEPE or docosahexaenoate (DHA) which lead to the formation of specialized pro-resolving mediators (SPM) lipoxin and resolvins E and D respectively, therefore it participates in anti-inflammatory responses (PubMed:17114001, PubMed:21206090, PubMed:31664810, PubMed:32404334, PubMed:32841762, PubMed:8615788). Oxidation of DHA directly inhibits endothelial cell proliferation and sprouting angiogenesis via peroxisome proliferator-activated receptor gamma (PPARgamma) (By similarity). It does not catalyze the oxygenation of linoleic acid and does not convert (5S)-HETE to lipoxin isomers (PubMed:31664810). In addition to inflammatory processes, it participates in dendritic cell migration, wound healing through an antioxidant mechanism based on heme oxygenase-1 (HO-1) regulation expression, monocyte adhesion to the endothelium via ITGAM expression on monocytes (By similarity). Moreover, it helps establish an adaptive humoral immunity by regulating primary resting B cells and follicular helper T cells and participates in the CD40-induced production of reactive oxygen species (ROS) after CD40 ligation in B cells through interaction with PIK3R1 that bridges ALOX5 with CD40 (PubMed:21200133). May also play a role in glucose homeostasis, regulation of insulin secretion and palmitic acid-induced insulin resistance via AMPK (By similarity). Can regulate bone mineralization and fat cell differentiation increases in induced pluripotent stem cells (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; GPR146 regulates pulmonary vascular remodeling by promoting pulmonary artery smooth muscle cell proliferation through 5-lipoxygenase., [RefSeq, PubMed]; Oncogenic PIK3CA recruits myeloid-derived suppressor cells to shape the immunosuppressive tumour microenvironment in luminal breast cancer through the 5-lipoxygenase-dependent arachidonic acid pathway., [RefSeq, PubMed]; The role of human 5-Lipoxygenase (5-LO) in carcinogenesis - a question of canonical and non-canonical functions. Review article, [RefSeq, PubMed]; This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 11,
        "reported_mutagensis": 30,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 18,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZLS0;E5FPY5;E5FPY7;E5FPY8;Q5JQ14",
        "ec_number_list": "3.4.19.12;3.6.4.13;2.7.1.35;1.1.1.42;2.4.2.1;3.4.21.46;1.16.3.1;1.11.1.6;4.1.2.13;2.4.1.1;5.3.1.9;5.1.3.-;3.4.23.5;3.4.22.52;2.4.2.7;3.4.22.1;3.6.4.10;3.2.1.31;2.5.1.18;2.7.10.2;1.13.11.-;1.13.11.34;3.3.2.6;3.4.11.4;1.11.1.7;1.1.1.205;4.2.99.18;5.6.2.4;3.6.5.-;4.2.1.24;3.4.19.1;5.3.2.1;5.3.3.12;2.7.11.1;2.7.1.40;3.4.24.35;3.1.6.14;3.1.6.12;1.13.11.31;1.13.11.33;1.13.11.12;3.2.1.23;2.7.1.11;5.4.2.11;5.4.2.4;2.7.4.6;2.7.13.3;3.4.22.27;2.7.11.24;3.5.4.5;5.4.2.2;2.4.1.186;3.6.1.-;2.7.1.1;2.7.1.-;2.3.3.8;3.6.4.6;5.2.1.8;3.1.1.47;3.1.1.-;3.5.4.6;1.11.1.24;2.7.11.39;3.5.1.23;3.5.1.-;3.5.1.109;2.7.11.22;2.7.11.23;2.3.2.5;4.4.1.20;2.5.1.-;2.3.2.26;3.6.1.6;5.4.2.7;3.4.25.1;2.3.2.27;3.4.18.1;4.1.2.4",
        "go_molecular_function": "GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;GO:0005506 iron ion binding;GO:0016787 hydrolase activity;GO:0016491 oxidoreductase activity;GO:0004052 arachidonate 12(S)-lipoxygenase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005635 nuclear envelope;GO:0005641 nuclear envelope lumen;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0034440 lipid oxidation;GO:0061044 negative regulation of vascular wound healing;GO:2001301 lipoxin biosynthetic process;GO:0050728 negative regulation of inflammatory response;GO:0002523 leukocyte migration involved in inflammatory response",
        "synthesized_glycan_count": 0,
        "hit_score": 25.0,
        "record_id": "P09917-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P48230-1",
        "uniprot_id": "T4S4_HUMAN",
        "mass": 21396.0,
        "length": 202,
        "protein_name": "Transmembrane 4 L6 family member 4",
        "gene_name": "TM4SF4",
        "organism": "Human",
        "refseq_name": "transmembrane 4 L6 family member 4",
        "refseq_ac": "NP_004608",
        "gene_names_uniprotkb": "TM4SF4; ILTMP",
        "gene_names_refseq": "ILTMP; TM4SF4; il-TMP",
        "protein_names_uniprotkb": "Transmembrane 4 L6 family member 4; IL-TMP; Intestine and liver tetraspan membrane protein",
        "protein_names_refseq": "intestinal and liver (il) tetraspan membrane protein; intestine and liver tetraspan membrane protein; transmembrane 4 L6 family member 4; transmembrane 4 superfamily member 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7104)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11237011;18765015;19159218;25344917;28129652;32972043;35051231;35946523;7665614",
        "class_list": "",
        "function": "Expression of transmembrane 4 superfamily member 4 (TM4SF4) and matrix metalloproteinase 26 (MMP26) was found to be significantly decreased during the implantation window in patients with polycystic ovary syndrome., [RefSeq, PubMed]; LncRNA ST8SIA6-AS1 facilitates hepatocellular carcinoma progression by governing miR-651-5p/TM4SF4 axis., [RefSeq, PubMed]; Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation., [UniProtKB]; Replacement of the transmembrane 4 L six family protein TM4SF1 or TM4SF4 C-terminus with that of TM4SF5 increased spheroids growth, transwell migration, and invasive dissemination from spheroids in 3D collagen gels., [RefSeq, PubMed]; TM4SF4 and LRRK2 Are Potential Therapeutic Targets in Lung and Breast Cancers through Outlier Analysis., [RefSeq, PubMed]; TM4SF4 expression was correlated with the increased expression of IGF1, consequently resulting in IGF1R activation in lung adenocarcinoma., [RefSeq, PubMed]; The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDA4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "GO:0042246 tissue regeneration",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "P48230-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "G2XKQ0-1",
        "uniprot_id": "SUMO5_HUMAN",
        "mass": 11526.0,
        "length": 101,
        "protein_name": "Small ubiquitin-related modifier 5",
        "gene_name": "SUMO1P1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "SUMO1P1; SUMO5; UBL2; UBL6",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Small ubiquitin-related modifier 5; SUMO-5; SUMO1 pseudogene 1; Ubiquitin-like 2; Ubiquitin-like 6",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162)",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "27211601;30675988;31844290;32157095;36215666;36241641",
        "class_list": "",
        "function": "Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Regulates the life cycle of promyelocytic leukemia nuclear bodies (PML-NBs). PolySUMO1P1/SUMO5 conjugation on 'Lys-160' of PML facilitates recruitment of PML-NB components, which enlarges PML-NB. SUMO1P1/SUMO5 also increases polySUMO2/3 conjugation of PML, resulting in RNF4-mediated disruption of PML-NBs., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0044389 ubiquitin-like protein ligase binding;GO:0031386 protein tag activity",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0030578 PML body organization;GO:0016925 protein sumoylation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "G2XKQ0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96PU5-1",
        "uniprot_id": "NED4L_HUMAN",
        "mass": 111932.0,
        "length": 975,
        "protein_name": "E3 ubiquitin-protein ligase NEDD4-like",
        "gene_name": "NEDD4L",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase NEDD4-like isoform 2",
        "refseq_ac": "NP_001138436",
        "gene_names_uniprotkb": "NEDD4L; KIAA0439; NEDL3",
        "gene_names_refseq": "NEDD4-2; NEDD4.2; NEDD4L; PVNH7; RSP5; hNEDD4-2",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase NEDD4-like; 2.3.2.26; 2.3.2.36; HECT-type E3 ubiquitin transferase NED4L; NEDD4.2; Nedd4-2",
        "protein_names_refseq": "E3 ubiquitin-protein ligase NEDD4-like isoform 2; HECT-type E3 ubiquitin transferase NED4L; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase; ubiquitin-protein ligase Rsp5",
        "tax_id": 9606,
        "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454); Liddle syndrome (Disease Ontology:DOID:0050477); stroke (Disease Ontology:DOID:0051061); periventricular nodular heterotopia 7 (Disease Ontology:DOID:0061270)",
        "pathway": " (hsa:23327);  (R-HSA-162588);  (R-HSA-2173788);  (R-HSA-2173795);  (R-HSA-2672351);  (R-HSA-983168)",
        "pathway_count": 6,
        "publication_count": 278,
        "publication_id_list": "10197981;10199400;10485843;10519551;10531062;10535941;10549282;10564087;10587642;10587654;10642508;10720933;10757800;10767424;10830164;10831588;11046148;11062501;11158580;11163210;11182090;11237011;11244092;11278251;11350924;11389444;11427533;11588175;11687798;11696533;11734858;11742982;11748237;11840194;11842292;11904445;11956057;12151385;12393854;12519765;12646216;12876068;12907679;12911626;1379744;14556380;14584882;14615060;14634667;14701756;14718519;14734113;15010458;15040001;15044175;15044642;15140763;15147738;15217910;15224091;15224092;15318163;15328345;15473846;15489223;15496141;15496163;15504734;15505377;15548568;15571818;15576372;15677482;15781469;15820681;15916532;15919655;16027725;16061177;16103266;16156666;16219661;16595681;16751101;16751102;16813530;16849430;16849449;16850186;16954532;17081983;17381423;17438144;17448995;17510063;17591695;17592128;17699613;17715136;17881003;18000046;18063579;18310267;18400985;18449189;18508966;18568018;18577513;18662336;18662542;18669648;18691976;18724360;18819914;19028597;19135894;19144635;19153159;19307298;19343052;19352404;19380724;19387438;19452197;19489725;19527882;19620632;19664597;19690332;19758997;19808995;19851334;19874575;19917253;19940261;19953639;20061380;20064473;20068231;20086093;20129061;20388639;20433953;20466723;20525693;20538786;20730100;20937913;21040849;21095583;21406692;21527911;21984732;22002868;22024150;22045334;22301619;22344298;2261476;22762019;22773952;22946059;2298749;23112050;23186163;2321095;23236378;23266279;23305486;23481700;23616951;23873930;23999003;24657276;24715725;2536303;25502872;25576301;25631046;25880248;25892735;26359375;26363003;26562072;26854353;27153775;27445338;27694961;27920218;27932573;28071645;28154142;28467828;28657654;28790369;28820317;28832583;28871256;28904123;29242379;29314611;29317506;29351928;29393594;29505301;29557506;29577978;29632046;30169966;30315122;30626607;30779550;30784271;31020640;31154438;31217245;31320629;31844290;31848261;31959741;31998317;32157095;32161166;32350084;32357974;32387766;32488085;32938616;33141586;33592498;33608556;33633747;33912179;33936100;33968037;33981976;34087483;34185709;34294877;34357683;34433824;34509645;34725712;34932366;35051231;35154160;35251023;35318648;35561310;35580925;36241641;36284347;37217939;39210401;39260747;40596516;7588753;7665160;7795595;8041726;8112288;8383669;8533761;8544406;8626462;8809036;9037075;9215638;9335507;9380723;9395096;9571199;9662395;9668046;9700209;9719863;9744806;9856985",
        "class_list": "",
        "function": "Alternate transcripts of Nedd4-2 may interact with ENaC differently. hNedd4-2 has role in regulation of ENaC. Protein domains are important for Nedd4-2 function. GeneRIF: Identification of multiple splice forms and 5' variants of Nedd4l.  5' variants inhibit ENaC-mediated Na+ transport when reconstituted in FRT epithelia.  Other splice forms encode Nedd4L isoforms with 2 to 4 WW domains having varying affinity for ENaC., [RefSeq, PubMed]; Candidate gene for autosomal dominant orthostatic hypotensive disorder., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; NEDD4L-mediated RASGRP2 suppresses high-glucose and oxLDL-induced vascular endothelial cell dysfunctions by activating Rap1 and R-Ras., [RefSeq, PubMed]; Results describe the isolation of three new NEDD4L transcripts designated NEDD4Lf, NEDD4Lg and NEDD4Lh, which encode different forms of the NEDD4L protein., [RefSeq, PubMed]; Significant association between several SNPs and hypertension in US whites, Greek whites, and African-Americans. Genetic variation in NEDD4L may play role in development or progression of some forms of hypertension. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]., [RefSeq]; Ubiquitination of angiotensin-converting enzyme 2 contributes to the development of pulmonary arterial hypertension mediated by neural precursor cell-expressed developmentally down-regulated gene 4-Like. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 20,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 4,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43165;Q3LSM7;Q7Z5F1;Q7Z5F2;Q7Z5N3;Q8N5A7;Q8WUU9;Q9BW58;Q9H2W4;Q9NT88",
        "ec_number_list": "2.7.11.1;2.3.2.24;2.3.2.23;2.3.2.26;2.3.2.27;2.3.2.31;3.6.4.6;2.3.2.-;2.7.11.30;6.2.1.-;2.3.2.34;2.3.2.32;5.2.1.8;3.6.4.-;2.3.2.25;2.3.2.36",
        "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0019871 sodium channel inhibitor activity;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0061630 ubiquitin protein ligase activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:2001288 positive regulation of caveolin-mediated endocytosis;GO:1901380 negative regulation of potassium ion transmembrane transport;GO:1903861 positive regulation of dendrite extension;GO:1903765 negative regulation of potassium ion export across plasma membrane;GO:0007528 neuromuscular junction development",
        "synthesized_glycan_count": 0,
        "hit_score": 28.3,
        "record_id": "Q96PU5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q969Q6-1",
        "uniprot_id": "P2R3C_HUMAN",
        "mass": 53316.0,
        "length": 453,
        "protein_name": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma",
        "gene_name": "PPP2R3C",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform 2",
        "refseq_ac": "NP_001292084",
        "gene_names_uniprotkb": "PPP2R3C; C14orf10; G5PR",
        "gene_names_refseq": "C14orf10; G4-1; G5pr; GDRM; MEGD; PPP2R3C; SPGF36",
        "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma; Protein phosphatase subunit G5PR; Rhabdomyosarcoma antigen MU-RMS-40.6A/6C",
        "protein_names_refseq": "protein phosphatase 2 (formerly 2A), regulatory subunit B''; protein phosphatase 2, regulatory subunit B'', gamma; protein phosphatase subunit G5PR; rhabdomyosarcoma antigen MU-RMS-40.6A; rhabdomyosarcoma antigen Mu-RMS-40.6C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform 2; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma",
        "tax_id": 9606,
        "disease": "spermatogenic failure 36 (Disease Ontology:DOID:0111921); gonadal dysgenesis, dysmorphic facies, retinal dystrophy, and myopathy (MONDO:MONDO:0032738)",
        "pathway": " (hsa:55012)",
        "pathway_count": 1,
        "publication_count": 57,
        "publication_id_list": "11237011;12167160;14654843;15820313;22753944;24333728;24714562;24715725;25418920;25505266;26154972;26992070;27846572;27862975;28228285;28514659;28904123;29437277;29493099;29557506;29632046;30315122;30410026;30893644;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34561969;34714774;34750818;34932366;35051231;35580925;36010968;36241641;36284347;36581221;37938771;39317195",
        "class_list": "",
        "function": "A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function., [RefSeq, PubMed]; Broad-spectrum XX and XY gonadal dysgenesis in patients with a homozygous L193S variant in PPP2R3C. Publication Status: Online-Only, [RefSeq, PubMed]; Expanding the spectrum of syndromic PPP2R3C-related XY gonadal dysgenesis to XX gonadal dysgenesis., [RefSeq, PubMed]; Findings suggest that protein phosphatase 2 regulatory subunit B (PPP2R3C) is involved in the ontogeny of multiple organs, especially critical for testis development and spermatogenesis, [RefSeq, PubMed]; G5PR expression is markedly augmented in the centrocytes of germinal centers after immunization of transgenic mice with T cell-dependent antigen., [RefSeq, PubMed]; Knockdown of PP5 and/or PPP2R3C increased P-gp expression and lowered the sensitivity to vincristine and doxorubicin. Consequently, results indicate that PP5/PPP2R3C negatively regulates P-gp expression and function., [RefSeq, PubMed]; May regulate MCM3AP phosphorylation through phosphatase recruitment (By similarity). May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex (PubMed:24333728). May play a role in the activation-induced cell death of B-cells (By similarity)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DEN7;D3DS97;D3DS98;Q5GJ55;Q5GJ56;Q6P4G2;Q86TZ3;Q9NWR9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0035303 regulation of dephosphorylation;GO:0000226 microtubule cytoskeleton organization;GO:0043029 T cell homeostasis;GO:0001782 B cell homeostasis;GO:0045579 positive regulation of B cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.8,
        "record_id": "Q969Q6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75935-1",
        "uniprot_id": "DCTN3_HUMAN",
        "mass": 21119.0,
        "length": 186,
        "protein_name": "Dynactin subunit 3",
        "gene_name": "DCTN3",
        "organism": "Human",
        "refseq_name": "dynactin subunit 3 isoform 3",
        "refseq_ac": "NP_001268354",
        "gene_names_uniprotkb": "DCTN3; DCTN22",
        "gene_names_refseq": "DCTN-22; DCTN22; DCTN3",
        "protein_names_uniprotkb": "Dynactin subunit 3; Dynactin complex subunit 22 kDa subunit; p22",
        "protein_names_refseq": "dynactin 3 (p22); dynactin complex subunit 22 kDa subunit; dynactin light chain; dynactin subunit 3 isoform 3",
        "tax_id": 9606,
        "disease": "McCune Albright syndrome (Disease Ontology:DOID:1858)",
        "pathway": " (hsa:11258);  (R-HSA-2132295);  (R-HSA-2565942);  (R-HSA-3371497);  (R-HSA-380259);  (R-HSA-380270);  (R-HSA-380284);  (R-HSA-380320);  (R-HSA-5620912);  (R-HSA-6807878);  (R-HSA-6811436);  (R-HSA-8854518)",
        "pathway_count": 12,
        "publication_count": 390,
        "publication_id_list": "10.1101/2023.09.13.557529;10036229;10052452;10064083;10072072;10318838;10359595;10445031;10480952;10540230;10559959;10559986;10562278;10593899;10631941;10631952;10639150;10679020;10747884;10748235;10761932;10809954;10903204;10921873;11035033;11076968;11080672;11172815;11237011;11285137;11306556;11461920;11483508;11529500;11589254;11684289;11689559;11701661;11703931;11726511;11748249;11751894;11790530;11813165;11853874;11956313;12047556;12070132;12078484;12198549;12207013;12221128;12364337;12388752;12401177;12432908;12447383;12634853;12742663;12748383;12781197;12852856;12925777;13486053;13678582;14580337;14654841;14731593;14742712;1493716;15037235;15159550;15381148;15483056;15498487;15591061;15616190;15632110;15705883;15728195;15749704;15813748;15878873;15911768;15914536;16030262;16181339;16207721;16242130;1631136;16314391;16357211;16403413;16462731;16618111;16633337;16723730;1680566;16824007;16890155;16912714;16926190;16940185;17142755;17253781;17274799;17283181;17360540;17429068;17451557;17488286;17574030;17591767;17646400;17719545;17760859;17804755;17827179;17927562;17956946;18037885;18046453;18086915;18182008;18215318;18243712;18254226;18283113;18292509;18378770;18477460;18521620;18524849;18566290;18615013;18635947;18641641;18664496;18694559;18801063;18809720;1898986;19004860;19015319;19081074;19109418;19164740;19296914;19359544;1956401;19564404;1957170;19631211;19635840;19753100;19758564;19940019;20006655;20038533;20072699;20230748;20308558;20357002;20399632;20420828;20427317;20558667;20637885;21116285;21158691;21173190;21183720;2121367;21219331;21273506;21347367;21376746;21422230;21441454;21548880;21565611;21620453;21689688;21700222;21725307;21792235;21796517;21844168;2190094;22011577;22013193;22094269;22094468;22130221;22179047;22266222;22304919;22318716;22365832;22433123;22433857;22562055;22641346;22653444;22791416;23141531;23141541;23253480;23333653;23348840;23400999;23481700;23530209;23747070;23769972;23783758;23789104;23839779;2391366;23921553;24012426;24053599;24089205;24119662;24231678;24469809;24694367;24715725;24806965;24891604;24982133;25047611;25233431;25313408;25418920;25436559;25453831;25492864;25532896;25576301;25645385;25880248;26073023;26154972;26203193;26313416;26375851;26992070;27462449;27600516;27663436;27846572;27920218;28083797;28218747;28228285;28301631;28755533;28832583;28904123;28919297;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632711;29786170;29789417;30197098;30315122;30410026;30429286;30484775;30524438;30779550;31110491;31141847;31154438;31217245;31222486;31530632;31731497;31826031;31844290;31848261;31937595;31998317;32016915;32157095;32161166;32320027;32357974;32387766;32448030;32488085;32502341;32544881;32897882;32938616;32982970;32983136;33141586;33298915;33392160;33402344;33592498;33691108;33896271;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34509645;35051231;35318648;35580925;36010968;36215666;36241641;37938771;6645495;6891012;7481823;7592972;7650016;7667286;7691276;7769006;7790358;8001155;8046351;8128252;8132710;8134367;8145819;8148318;8157723;8221884;8253837;8282004;8313912;8397411;8415765;8505331;8560673;8620540;8636227;8642258;8687433;8838651;8849454;8909537;8939989;8947036;8991093;9030515;9050864;9075930;9114004;9150144;9177194;9202021;9244307;9288971;9311912;9312039;9323141;9380700;9382863;9405360;9464360;9464361;9490716;9497313;9539769;9545226;9606180;9667968;9671725;9671731;9722614;9733780;9751720;9990005",
        "class_list": "",
        "function": "Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Together with dynein may be involved in spindle assembly and cytokinesis (PubMed:9722614)., [UniProtKB, PubMed, UniProtKB]; Study on the Prognostic Values of Dynactin Genes in Low-Grade Glioma., [RefSeq, PubMed]; This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NII7;B2RBM5;Q5T1I5;Q5T1I7;Q5T8G3;Q9BPU8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005198 structural molecule activity",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0032154 cleavage furrow",
        "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0061640 cytoskeleton-dependent cytokinesis",
        "synthesized_glycan_count": 0,
        "hit_score": 39.4,
        "record_id": "O75935-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95865-1",
        "uniprot_id": "DDAH2_HUMAN",
        "mass": 29644.0,
        "length": 285,
        "protein_name": "Putative hydrolase DDAH2",
        "gene_name": "DDAH2",
        "organism": "Human",
        "refseq_name": "putative hydrolase DDAH2",
        "refseq_ac": "NP_001289936",
        "gene_names_uniprotkb": "DDAH2; DDAH; G6A; NG30",
        "gene_names_refseq": "DDAH2; DDAHII; DDAH; G6a; HEL-S-277; NG30",
        "protein_names_uniprotkb": "Putative hydrolase DDAH2; 3.-.-.-; DDAH-2; DDAHII; Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2; Inactive dimethylarginine dimethylaminohydrolase 2; Protein G6a; S-phase protein",
        "protein_names_refseq": "S-phase protein; dimethylargininase-2; dimethylarginine dimethylaminohydrolase II; epididymis secretory protein Li 277; inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2; inactive dimethylarginine dimethylaminohydrolase 2; n(G),N(G)-dimethylarginine dimethylaminohydrolase 2; putative hydrolase DDAH2; testis tissue sperm-binding protein Li 54e",
        "tax_id": 9606,
        "disease": "pseudohypoparathyroidism type 1C (Disease Ontology:DOID:0051013); pseudohypoparathyroidism type 1A (Disease Ontology:DOID:0080053); pseudohypoparathyroidism type 1B (Disease Ontology:DOID:0080222); polycystic kidney disease (Disease Ontology:DOID:0080322); progressive osseous heteroplasia (Disease Ontology:DOID:0111535); ACTH-independent macronodular adrenal hyperplasia 1 (Disease Ontology:DOID:0111623); pituitary adenoma 3 (Disease Ontology:DOID:0112010); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); pancreatic cancer (Disease Ontology:DOID:1793); McCune Albright syndrome (Disease Ontology:DOID:1858); pseudopseudohypoparathyroidism (Disease Ontology:DOID:4183); pseudohypoparathyroidism (Disease Ontology:DOID:4184); cholangiocarcinoma (Disease Ontology:DOID:4947); schizophrenia (Disease Ontology:DOID:5419); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:23564)",
        "pathway_count": 1,
        "publication_count": 30,
        "publication_id_list": "10384126;10493931;11237011;14656967;19413330;21493890;21898353;28657654;30379171;30429286;31154438;31844290;31848261;32350084;32502341;32938616;33850055;33968037;34087483;34105348;34283907;35251023;35254053;36010968;36233204;37296100;37340703;38665916;38765527;40596516",
        "class_list": "",
        "function": "Assessment of DDAH1 and DDAH2 Contributions to Psychiatric Disorders via In Silico Methods. Publication Status: Online-Only, [RefSeq, PubMed]; DDAH-2 could play an important role in IL-1beta-induced NO production and in osteoarthritis pathogenesis., [RefSeq, PubMed]; Early and late-onset preeclampsia: effects of DDAH2 polymorphisms on ADMA levels and association with DDAH2 haplotypes. Publication Status: Online-Only, [RefSeq, PubMed]; Polymorphism (-499C/G) in DDAH2 promoter may act as a protective factor for metabolic syndrome: A case-control study in Azar-Cohort population., [RefSeq, PubMed]; Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (PubMed:21493890, PubMed:37296100). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (By similarity). Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (PubMed:33850055)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a dimethylarginine dimethylaminohydrolase. The encoded enzyme functions in nitric oxide generation by regulating the cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. The protein may be localized to the mitochondria. Alternative splicing resulting in multiple transcript variants. [provided by RefSeq, Dec 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 16,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2BEZ7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045429 positive regulation of nitric oxide biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "O95865-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NEG2-1",
        "uniprot_id": "CG057_HUMAN",
        "mass": 32846.0,
        "length": 295,
        "protein_name": "Uncharacterized protein C7orf57",
        "gene_name": "C7orf57",
        "organism": "Human",
        "refseq_name": "uncharacterized protein C7orf57 isoform 1",
        "refseq_ac": "NP_001093629",
        "gene_names_uniprotkb": "C7orf57",
        "gene_names_refseq": "C7orf57; FCAP33",
        "protein_names_uniprotkb": "Uncharacterized protein C7orf57",
        "protein_names_refseq": "uncharacterized protein C7orf57 isoform 1; uncharacterized protein C7orf57",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:136288)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "11237011;19193627",
        "class_list": "",
        "function": "Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JBJ8",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q8NEG2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P42224-1",
        "uniprot_id": "STAT1_HUMAN",
        "mass": 87335.0,
        "length": 750,
        "protein_name": "Signal transducer and activator of transcription 1-alpha/beta",
        "gene_name": "STAT1",
        "organism": "Human",
        "refseq_name": "signal transducer and activator of transcription 1-alpha/beta isoform alpha",
        "refseq_ac": "NP_009330",
        "gene_names_uniprotkb": "STAT1",
        "gene_names_refseq": "CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT1; STAT91",
        "protein_names_uniprotkb": "Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84",
        "protein_names_refseq": "signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1-alpha/beta isoform alpha; signal transducer and activator of transcription 1-alpha/beta; transcription factor ISGF-3 components p91/p84",
        "tax_id": 9606,
        "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); immunodeficiency 31B (Disease Ontology:DOID:0111944); immunodeficiency 31A (Disease Ontology:DOID:0111945); immunodeficiency 31C (Disease Ontology:DOID:0111946); breast cancer (Disease Ontology:DOID:1612); hepatitis C (Disease Ontology:DOID:1883); nephroblastoma (Disease Ontology:DOID:2154); colon adenocarcinoma (Disease Ontology:DOID:234); prostate adenocarcinoma (Disease Ontology:DOID:2526); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); angiomyolipoma (Disease Ontology:DOID:3314); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); breast carcinoma (Disease Ontology:DOID:3459); gastric adenocarcinoma (Disease Ontology:DOID:3717); pulmonary fibrosis (Disease Ontology:DOID:3770); tuberculosis (Disease Ontology:DOID:399); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:6772);  (R-HSA-1059683);  (R-HSA-1169408);  (R-HSA-1433557);  (R-HSA-1839117);  (R-HSA-186763);  (R-HSA-6785807);  (R-HSA-8854691);  (R-HSA-8939902);  (R-HSA-8984722);  (R-HSA-8985947);  (R-HSA-9013508);  (R-HSA-9020956);  (R-HSA-9020958);  (R-HSA-909733);  (R-HSA-9670439);  (R-HSA-9673767);  (R-HSA-9673770);  (R-HSA-9674555);  (R-HSA-9680350);  (R-HSA-9705462);  (R-HSA-9705671);  (R-HSA-9725370);  (R-HSA-982772);  (R-HSA-9833482);  (R-HSA-9860927);  (R-HSA-9909649)",
        "pathway_count": 27,
        "publication_count": 1290,
        "publication_id_list": "10023775;10082513;10215629;10216106;10219247;10329948;10348343;10358045;10369418;10377264;10383940;10395669;10397721;10400669;10453004;10480903;10508235;10510379;10523304;10523831;10523834;10537111;10542198;10542297;10556217;10562299;10570180;10572046;10579907;10586089;10620360;10626894;10643150;10645003;10648614;10679268;10688839;10702393;10702714;10706082;10706887;10748192;10753717;10777583;10820245;10848580;10851062;10866685;10867011;10875937;10878008;10884405;10887137;10911365;10918587;10918594;10919676;10934142;10935490;10940874;10964718;10982844;11016959;11023524;11058569;11084045;11092454;11095724;11096080;11104795;11110708;11112487;11120780;11121117;11134010;11152457;11152499;11156368;11157743;11163236;11196675;11237011;11238103;11238927;11278437;11278462;11278729;11278865;11280786;11294897;11306517;11309387;11310834;11313968;11337497;11337501;11350938;11356008;11369651;11377645;11390453;11390454;11395417;11404376;11404481;11418623;11438540;11438544;11442634;11452125;11463377;11481447;11494148;11500375;11504915;11520784;11564763;11585831;11641425;11675348;11689702;11706020;11707405;11739186;11751994;11777927;11781817;11788588;11809791;11823427;11839738;11850821;11866432;11884587;11886239;11909525;11939789;11943732;11960372;11972023;11985496;11988758;12000792;12019269;12029096;12062105;12068083;12087100;12093291;12112524;12121660;12124177;12133942;12138178;12185581;12192036;12223098;12223527;12231563;12232043;12232802;12242343;12244150;12351624;12386158;12393597;12397061;12424201;12469119;12475982;12481435;12483717;12511554;12517932;12522257;12525615;12526087;12569364;12582176;12590259;12600988;12637327;12660731;12692549;12734330;12738770;12748293;12750159;12759408;12759422;12764129;12766484;12799548;12800156;12804067;12807916;12811837;12817007;12824176;12829785;12832402;12842042;12855578;12856330;12878163;12882960;12882984;12883649;12907755;12920229;12923053;12934099;12949711;12971583;1314164;1334462;1371879;1373135;1374684;1375232;1375321;1376929;1381360;1396585;14512302;14565860;14580208;14585331;14634100;14648593;14660670;14695343;14712222;14764663;14764690;14769151;14962911;14963018;14978097;14978237;15007386;1502203;15034873;15039213;15047845;15050920;15107455;15116091;15120653;15131269;15140960;15143187;15166220;15169778;15178681;15182726;15208624;15208656;15221957;15229216;15261459;15284024;15297606;15299030;15312780;15320963;15322115;15374880;15448205;15449939;15485925;1549776;15526160;15584925;15585657;15588951;15601820;15609342;15695932;15702989;15703179;15728510;15737233;15752359;15778442;15790786;15800673;15805299;15825084;15850832;15869882;15895073;15907845;15919823;15928335;15950906;15994321;15994429;16007214;16009940;16048438;16059651;16107692;16112642;16115867;16122702;16129412;16139798;16153455;16161041;16170336;16171819;16179258;16179259;16188233;16204068;16205632;16236134;16257975;16260419;16314732;16324152;16324217;16343349;16352599;16373505;1638633;16397018;16397263;16407192;16418217;16421188;16428300;16431927;16451196;16483568;16492764;16510571;16516295;16540365;16600570;16606674;1662392;16699525;16707477;16715065;16717090;16720384;16728642;16729885;16737840;16750817;16775314;16799645;16815975;16825495;16868551;16871283;16872604;16873377;16908864;16914094;16918696;16934001;16939498;16946300;1695551;16959974;16982605;16982608;16987978;1701053;17072862;17075845;17079286;17086210;17196820;1721591;17237409;17251292;17255936;17258468;17277783;17289916;17293456;1730654;17311277;17325127;17344430;17351669;17353907;17363902;17371985;17376915;17383622;17416736;17427945;17452978;17458857;17483340;17488182;17502367;17525742;17533378;17546049;17561467;17565448;17572495;17579625;17622177;17625570;17662946;17686504;17696225;17698633;17785551;17785783;17786208;17874423;17878297;17879956;17897103;17933493;17969444;17986321;18033300;18035202;18096616;18097461;18190974;18205209;18243101;18250158;18280240;18287095;18292512;18305167;18353781;18378670;18389480;18412956;18447642;18452278;18452557;18467591;18488018;18519587;18541707;18574148;18575461;18583345;18591661;18593892;18594010;18599299;18644434;18644974;18669613;18669648;18691976;18697750;18701132;18721752;18724359;18817573;18830264;18835251;18923523;18923524;18923525;18941194;18941537;18957415;18974129;18991276;19052084;19073728;19088198;19088846;19124156;19125153;19136629;19174562;19185846;19214187;19229320;19265199;19270716;19349465;19367337;19369959;19396596;19397496;19397895;19404407;19416861;19453968;19456272;19457860;19459784;1948064;19502801;19535621;19551150;19690332;19710021;19733181;19801665;19802003;19804757;19838063;19846878;19874848;19915063;19927328;19933857;20006573;20058876;20068231;20130243;20133869;20169197;20219937;20226962;20304997;20308324;20353823;20363976;20385878;20395957;20454865;20462497;20489731;20493732;20504369;20519500;20519510;20643137;20671117;20675591;20685959;20738848;20841510;20889717;20927104;20966397;20974954;21049007;21072047;21084836;21098725;21102457;21123651;21134980;21135090;21164297;21189227;21213368;21252155;21294215;21303487;21311224;21330321;21345084;21351482;21415216;21439476;2147944;21494621;21518807;21533215;21545749;21596819;21631431;21636578;21654841;21656749;21689689;21714643;21724836;21727188;21730069;21783819;21838707;21847362;21878628;21931630;21937440;21937648;2196173;21968657;21978664;21992896;21993680;21994466;21994559;21999474;22009320;22038826;22046235;22065572;22089421;22110204;2211721;22126015;22153499;22205702;22214662;22223895;22249260;22306001;22306691;22327622;22347464;22355301;22383755;22383882;22396495;22422618;22424782;22435755;2247437;22483114;22487722;22527947;22544926;22570254;22573496;2261637;22658521;22693070;22788969;22802649;22814351;22823229;22851691;22898188;22920439;22941947;22962576;22986343;22996189;23013371;23043228;23061660;23073628;23084476;23086340;23104988;23121362;23124025;23139213;23172665;23174178;23178573;23186163;23201355;23221969;23229543;23239810;23245396;23257612;23349666;23352233;23403054;23440042;23449448;23455323;23481700;23555662;23580655;23597922;23633948;23637938;23661334;23709754;23732991;23752188;23760261;23783831;23825585;23845085;23917221;23940278;23943595;23957430;23967200;23970477;24014650;24029068;24058793;24060861;24065129;24069555;24097101;24131713;24166946;24220695;24255956;24319264;24347309;24366607;24417533;24445538;24449862;24475247;24496003;24518094;24572363;24613930;24623135;24646078;24659800;2466336;24687822;24699362;24714562;24715725;2472219;24725474;24728078;24736082;24743305;24743777;24753571;24771852;24788809;24838635;24839978;24886089;24890514;24911872;25004819;25114211;25170834;25226283;25234944;25239608;25260729;25271420;25288569;25297818;25340519;25342631;25371710;25393796;25417103;25418920;25421750;25502872;25505266;25535969;25572173;25576301;25605239;25645385;25653431;25686822;25690042;25753288;25802875;25813404;25848059;25858560;25880248;25880691;25892735;25921060;25941617;25950470;25992861;25995822;26001147;26029847;26062823;26091038;26113305;26141950;26154972;26155422;26232434;26235028;26265185;26279360;26301689;26342467;26351076;26375851;26432638;26446704;26479788;26488609;26514428;26604104;26716879;26728094;26735690;26778333;26783516;26811146;26817845;26839680;26992070;27074819;27080594;27119567;27133025;27170215;27208315;27245569;27269119;27387064;27423063;27434509;27457515;27486982;27536065;27543614;27573755;27600516;27749937;27774606;27791205;27796300;27841855;27846572;27862183;27862975;27874193;2788034;27893789;27920218;27974558;28059079;28063628;28069888;28086195;28167698;28192400;28218747;28228285;2825030;28262979;28281686;28351781;28403213;28404650;28422713;28430601;28431406;28432285;28446606;28458652;28467828;28471454;28514659;28542650;28550731;28560754;28659337;28676732;28741662;28753426;28765891;28832583;28834231;28855257;28859974;28860189;28904123;28923937;29170442;29175459;29231267;29234062;29239838;29242379;29270166;29331515;29348488;29348664;29351928;29371942;29374380;29393594;29394925;29395325;29408302;29437277;29440070;29455642;29474442;29493099;29501855;29508533;29540832;29557506;29604049;29632046;29632711;29686406;29691476;29704617;29751820;29769354;29786170;29789417;29796172;29855346;29858569;29873274;29893425;29925830;29930380;29946223;29964125;30007645;30131584;30150992;30174290;30315122;30323286;30373602;30385408;30389923;30410026;30429286;30455980;30485383;30524438;30619249;30644389;30687322;30692217;30724425;30770398;30779550;30792533;30833945;30886199;30940163;30952894;30967527;31031002;31085175;31154438;31196219;31202985;31205408;31217245;31222486;31366041;31408005;31408443;31530632;31653890;31804622;31840082;31844290;31846457;31848261;31850239;31918717;31937595;31998317;32032529;32032660;32037480;32093270;32113509;32123171;32157095;32161166;32183180;32183950;32196427;32209697;32286295;32306778;32319563;32350084;32353859;32357974;32358509;32387766;32420725;32428392;32488085;32502341;32511913;32574262;32589897;32606936;32642677;32661006;32673515;32696599;32699158;32716602;32726803;32728199;32731335;32758689;32792604;32801355;32814877;32831137;32860047;32862111;32864202;32897882;32938616;32938761;32953130;32979938;32983136;33024073;33046973;33060197;33097660;33110251;33117408;33141586;33189161;33193462;33208444;33298915;33314148;33349665;33360543;33361763;33372174;33372854;33389635;33391546;33392160;33396578;33396605;33440148;33479219;3349036;33495715;33504682;33514628;33519429;33537174;33567255;33592498;33633747;33644712;33691108;33692335;33717175;33718825;33723219;33723527;33727702;33734579;33747209;33779079;33801464;33807682;33808629;33815425;33849972;33895773;33911136;33912179;33936100;33963333;33968037;33981976;33989516;33990585;34021074;34054808;34078123;34084167;34087483;34110168;34166398;34171305;34174402;34185709;34211107;34239064;34290717;34319780;34341353;34357683;34375313;34400613;34405274;34439781;34452305;34471099;34502139;34508746;34509645;34561969;34597346;34932366;34974812;35051231;35102342;35154160;35318648;35537286;35561310;35568036;35580925;35643212;35685460;35705054;35712699;35874702;35947956;36010968;36154299;36215666;36241641;36284347;36342456;36581221;36712380;37051252;37127961;37938771;38621137;40307207;6162102;6548414;688397;7491766;7504784;7506952;7509796;7510216;7512451;7512720;7515177;7521688;7523381;7526154;7526158;7529288;7536744;7537377;7540766;7543024;7543512;7545299;7559393;7565688;7592750;7597091;7657660;7680037;7681396;7685273;7690989;7691587;7691811;7692233;7693978;7701321;7718508;7737357;7737969;7775604;7795521;7796300;7805849;7812050;7824924;7871433;7885841;7898939;7903669;7907877;7935391;8022485;8085155;8134389;8140422;8156998;8188682;8197119;8197134;8232552;8272873;8343952;8355686;8388543;8443409;8483502;8523587;8576172;8576179;8602263;8605876;8605877;8611693;8621447;8621622;8633037;8636116;8647802;8647855;8657151;8661426;8662591;8662795;8663118;8668165;8695790;8702790;8756628;8774734;8797861;8810342;8816495;8830676;8910500;8940081;8940092;8943348;8950973;8977235;8981370;8990121;9013879;9030599;9034343;9038210;9045650;9058373;9079663;9096384;9111318;9121453;9225065;9226159;9242679;9256427;9285712;9334213;9342359;9353323;9355737;9382798;9399961;9425908;9438854;9442054;9446650;9484840;9488729;9521856;9525617;9528799;9535918;9546424;9576949;9630226;9649436;9651359;9660177;9687506;9716603;9723655;9724754;9736340;9737981;9739761;9788619;9794795;9799234;9819383;9819388;9822675;9847332;9861020;9864153;9872323;9874564;9885206;9920933;9949182;9989503",
        "class_list": "",
        "function": "Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors (PubMed:12764129, PubMed:12855578, PubMed:15322115, PubMed:23940278, PubMed:34508746, PubMed:35568036, PubMed:9724754, PubMed:32814877). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426, PubMed:35568036). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state (PubMed:28753426, PubMed:35568036). In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state (PubMed:8156998). Becomes activated in response to KITLG/SCF and KIT signaling (PubMed:15526160). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:19088846). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylated at Thr-749 by IKBKB which promotes binding of STAT1 to the 5'-TTTGAGGC-3' sequence in the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). Phosphorylation at Thr-749 also promotes binding of STAT1 to the 5'-TTTGAGTC-3' sequence in the IL12B promoter and activation of IL12B transcription (PubMed:32209697). Involved in food tolerance in small intestine: associates with the Gasdermin-D, p13 cleavage product (13 kDa GSDMD) and promotes transcription of CIITA, inducing type 1 regulatory T (Tr1) cells in upper small intestine (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 28,
        "reported_mutagensis": 31,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 19,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K989;B2RCA0;D2KFR8;D3DPI7;Q53S88;Q53XW4;Q68D00;Q9UDL5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0045296 cadherin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0070106 interleukin-27-mediated signaling pathway;GO:0032727 positive regulation of interferon-alpha production;GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0072162 metanephric mesenchymal cell differentiation;GO:0046725 negative regulation by virus of viral protein levels in host cell",
        "synthesized_glycan_count": 0,
        "hit_score": 129.8,
        "record_id": "P42224-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14974-1",
        "uniprot_id": "MYPT1_HUMAN",
        "mass": 115281.0,
        "length": 1030,
        "protein_name": "Protein phosphatase 1 regulatory subunit 12A",
        "gene_name": "PPP1R12A",
        "organism": "Human",
        "refseq_name": "protein phosphatase 1 regulatory subunit 12A isoform a",
        "refseq_ac": "NP_001137357",
        "gene_names_uniprotkb": "PPP1R12A; MBS; MYPT1",
        "gene_names_refseq": "GUBS; M130; MBS; MYPT1; PPP1R12A",
        "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 12A; Myosin phosphatase target subunit 1; Myosin phosphatase-targeting subunit 1; Protein phosphatase myosin-binding subunit",
        "protein_names_refseq": "myosin binding subunit; myosin phosphatase, target subunit 1; myosin phosphatase-targeting subunit 1; protein phosphatase 1 regulatory subunit 12A isoform a; protein phosphatase 1, regulatory (inhibitor) subunit 12A; protein phosphatase myosin-binding subunit",
        "tax_id": 9606,
        "disease": "genitourinary and/or brain malformation syndrome (MONDO:MONDO:0032934)",
        "pathway": " (hsa:4659);  (R-HSA-2565942);  (R-HSA-5625740);  (R-HSA-5625900);  (R-HSA-5627117);  (R-HSA-5627123)",
        "pathway_count": 6,
        "publication_count": 307,
        "publication_id_list": "10047984;10092231;10330186;10470034;10567269;10579722;10601309;10619026;10639334;10748018;10753910;10924361;10947843;10975528;11067852;11068043;11134534;11237011;11278486;11283607;11287000;11313932;11331307;11342221;11719507;11804587;11931630;11942626;12030846;12198493;12207013;12220642;12364337;12453877;12563012;12600888;12750860;12773565;12783890;12802051;12873707;12923170;13678582;14514689;14580336;15000491;15003508;15124925;15144186;15184667;15194681;15226371;15378014;15475516;15570572;15665049;15723050;15791647;16202622;16204230;16417406;16431929;16608882;16854367;16890155;17081983;17126281;17301291;17697703;17904578;17924679;18006505;18077418;18088087;18094049;18212344;18237278;18374184;18378770;18423375;18452278;18477460;18491316;18521620;18566290;18615013;18648664;18669648;18767875;18782776;18829550;18840611;19095646;19131646;19245366;19289088;19367720;19413330;19415658;19513348;19531490;19651622;19664994;19664995;19690332;19701943;19723632;19806255;19879105;19901323;19997641;20058876;20068231;20130087;20166139;20305658;20354225;20444238;20634291;20801872;21098037;21351730;21406692;21457715;21740066;21749319;21850162;22020732;22155728;22293177;22365832;22530104;22641346;22661428;22869619;22947248;22948155;22967762;23161543;23186163;23301498;23308222;23345589;23362260;23444367;23481700;23516539;23716662;24100445;24128008;24166499;24171924;24356468;24397554;24712327;24714562;24715725;24815187;24859002;24993595;25168281;25367160;25418920;25576301;25645385;25980620;26154972;26375851;26811146;26992070;27114449;27397612;27600516;27655845;27725371;27846572;27862975;27920218;28063628;28191820;28218747;28228285;28278256;28300193;28387646;28411811;28514659;28657654;28827520;28832583;28834231;28904123;29154753;29237092;29242379;29262732;29331515;29351928;29393594;29437277;29493099;29508533;29511289;29557506;29632046;29632711;29786170;29789417;30059200;30379171;30429286;30446640;30620550;30779550;3079756;31138649;31154438;31217245;31373491;31416392;31492838;31530632;31637018;31834925;31844290;31848261;31883643;31937595;31998317;32119511;32157095;32295844;32350084;32357974;32387766;32421147;32488085;32502341;32574038;32679023;32897882;32938616;32938750;32983136;33123756;33141586;33214551;33298915;33402344;33592498;33717175;33802280;33912179;33936100;33968037;34019870;34019948;34171305;34357683;34509645;34561969;34725712;34846842;34932366;35051231;35132862;35138101;35251023;35254053;35289036;35318648;35513511;35561310;35580925;35705054;36240223;36284347;37217939;37541260;37938771;3839510;38615553;38665916;39302247;39334371;39531497;39534244;40136647;40307207;40596516;40914422;41350704;41518202;7559638;8107774;8543060;8662509;9278512;9286714;9354661;9535855;9683637;9792683;9870942;9870943;9889122;9988689",
        "class_list": "",
        "function": "Differential expression of PPP1R12A transcripts, including those harbouring alternatively spliced micro-exons, in placentae from complicated pregnancies., [RefSeq, PubMed]; Functional analysis of a novel nonsense PPP1R12A variant in a Chinese family with infantile epilepsy. Publication Status: Online-Only, [RefSeq, PubMed]; Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 2,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 2,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 62,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 62,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 62,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 71,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 82,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 62,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DZ09;F8VWB4;Q2NKL4;Q569H0;Q86WU3;Q8NFR6;Q9BYH0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0017020 myosin phosphatase regulator activity;GO:0004857 enzyme inhibitor activity;GO:0019901 protein kinase binding;GO:0071889 14-3-3 protein binding;GO:0019208 phosphatase regulator activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005925 focal adhesion",
        "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007165 signal transduction;GO:0030155 regulation of cell adhesion;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0043086 negative regulation of catalytic activity",
        "synthesized_glycan_count": 0,
        "hit_score": 37.2,
        "record_id": "O14974-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TEB1-1",
        "uniprot_id": "DCA11_HUMAN",
        "mass": 61670.0,
        "length": 546,
        "protein_name": "DDB1- and CUL4-associated factor 11",
        "gene_name": "DCAF11",
        "organism": "Human",
        "refseq_name": "DDB1- and CUL4-associated factor 11 isoform 1",
        "refseq_ac": "NP_001156956",
        "gene_names_uniprotkb": "DCAF11; GL014; PRO2389; WDR23",
        "gene_names_refseq": "DCAF11; GL014; PRO2389; WDR23",
        "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 11; WD repeat-containing protein 23",
        "protein_names_refseq": "DDB1- and CUL4-associated factor 11 isoform 1; WD repeat domain 23; WD repeat-containing protein 23",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80344);  (R-HSA-8951664)",
        "pathway_count": 2,
        "publication_count": 170,
        "publication_id_list": "10.1101/2023.09.13.557529;10535940;10597293;10811609;10878807;10973499;11069780;11237011;11259415;11292861;11292862;11454738;11585840;11733065;11961546;12101228;12186903;12504025;12504026;12526791;12538644;12609982;12682069;12759363;12816948;14690597;14757770;15282312;15361859;15367669;15537541;15572695;15574592;15601839;15652483;15688063;15694336;15799966;16171779;16401342;16547496;16647857;16707496;16790436;16943200;16949367;16964240;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18093314;18206966;18775313;18776931;18805092;18826954;18851830;18926707;19250909;19273594;19321346;19617556;19748355;21447816;21463634;21778237;21863050;21940857;22306028;22424782;22466964;22537386;22544926;22959436;23201271;23333871;23401859;23453757;23481700;23535662;23535663;23563313;23583660;23912815;23986495;24076655;24366543;24636985;24715725;24793695;24793696;25314029;25349211;25355947;25505266;25531226;25576301;25645385;25892735;26154972;26344709;26460955;26632597;26906416;26992070;27030794;27222660;27565346;27846572;27862975;27920218;28115426;28218747;28832583;28834231;28860189;28904123;29153394;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30429286;30524438;30573663;30610225;31154438;31217245;31844290;31848261;31937595;31998317;32005965;32157095;32284348;32387766;32502341;32839090;32897882;32938616;32983136;33141586;33298915;33444648;33592498;33717175;33783207;33912179;33936100;33968037;34185709;34211107;35051231;35154160;35580925;36010968;40914422;9790970;9887101;9891082",
        "class_list": "",
        "function": "DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras., [RefSeq, PubMed]; Includes the functional characterization of a similar protein in C. elegans and comparison to the human protein., [RefSeq, PubMed]; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex., [UniProtKB, PubMed, PubMed]; This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]., [RefSeq]; WDR23 regulates the expression of Nrf2-driven drug-metabolizing enzymes., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KQ83;D3DS56;Q5D039;Q86U00;Q86U39;Q8NDN2;Q9H2J0;Q9H3A3;Q9H5C9",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0080008 Cul4-RING E3 ubiquitin ligase complex",
        "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:1902412 regulation of mitotic cytokinesis;GO:0080135 regulation of cellular response to stress",
        "synthesized_glycan_count": 0,
        "hit_score": 17.5,
        "record_id": "Q8TEB1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q04725-1",
        "uniprot_id": "TLE2_HUMAN",
        "mass": 79841.0,
        "length": 743,
        "protein_name": "Transducin-like enhancer protein 2",
        "gene_name": "TLE2",
        "organism": "Human",
        "refseq_name": "transducin-like enhancer protein 2 isoform 2",
        "refseq_ac": "NP_001138233",
        "gene_names_uniprotkb": "TLE2",
        "gene_names_refseq": "ESG2; ESG; GRG2; TLE2",
        "protein_names_uniprotkb": "Transducin-like enhancer protein 2; ESG2; Enhancer of split groucho-like protein 2",
        "protein_names_refseq": "enhancer of split groucho-like protein 2; transducin like enhancer of split 2; transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 2, homolog of Drosophila E(sp1); transducin-like enhancer protein 2 isoform 2; transducin-like enhancer protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7089);  (R-HSA-201722);  (R-HSA-2122947);  (R-HSA-3769402);  (R-HSA-4641265)",
        "pathway_count": 5,
        "publication_count": 160,
        "publication_id_list": "10080941;10375506;10485845;10549281;10559189;10713164;10769018;10775268;10831834;10898789;10919662;10921920;10944533;10964718;11044625;11050151;11080158;11136974;11237011;11266540;11290324;11461910;11532957;11585921;11691915;11713476;11934263;11955446;11973335;11988739;12050117;12163411;12391150;12408824;12408825;12711682;12712206;1303260;14600025;14685266;14695187;14980219;15060161;15107403;15121853;15132997;15187083;15294866;15327769;15525529;15546612;15768032;15829968;16005293;16169192;16256737;16510874;16530044;16547505;16630820;16756492;17052462;17114293;17218525;17412698;17425782;17428831;17458864;17698607;17875931;18094723;18160704;18254933;18347063;18374649;18378692;18404694;18456656;18498752;18573912;18598779;18621708;18669648;18721877;18819930;19047045;19148484;19364920;19460168;19487454;19493659;19571879;19590513;19928349;19939918;19940019;20405012;20972443;21654818;21726809;22186018;22190459;22304967;22617422;22982193;23256519;23481700;24291232;24715725;25576301;25645385;26992070;27600516;27846572;27893789;27920218;28657654;28832583;28834231;28855257;29242379;29393594;29632046;29786170;30833945;31154438;31222486;31844290;32357974;32502341;33298915;33592498;33936100;34019948;34087483;34171305;35051231;35580925;36284347;40307207;7566092;7588063;8001118;8365415;8649374;8687460;8756721;8757136;8955148;9118222;9488439;9490669;9694793;9751710;9783587;9819412;9843967;9854018;9874198;9887105",
        "class_list": "",
        "function": "Immunofluorescence analysis showed that TLE2 and RTA were colocalized in the same nuclear compartment in KSHV-infected cells., [RefSeq, PubMed]; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity)., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DE03;E9PEV7;F8WCH2;Q8WVY0;Q9Y6S0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003714 transcription corepressor activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0005667 transcription regulator complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0045892 negative regulation of DNA-templated transcription;GO:0009887 animal organ morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 16.6,
        "record_id": "Q04725-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q10586-1",
        "uniprot_id": "DBP_HUMAN",
        "mass": 34349.0,
        "length": 325,
        "protein_name": "D site-binding protein",
        "gene_name": "DBP",
        "organism": "Human",
        "refseq_name": "D site-binding protein",
        "refseq_ac": "NP_001343",
        "gene_names_uniprotkb": "DBP",
        "gene_names_refseq": "DABP; DBP; taxREB302",
        "protein_names_uniprotkb": "D site-binding protein; Albumin D box-binding protein; Albumin D-element-binding protein; Tax-responsive enhancer element-binding protein 302; TaxREB302",
        "protein_names_refseq": "D site of albumin promoter (albumin D-box) binding protein; D site-binding protein; albumin D box-binding protein; albumin D-element-binding protein; tax-responsive enhancer element-binding protein 302",
        "tax_id": 9606,
        "disease": "acute lymphoblastic leukemia (Disease Ontology:DOID:9952)",
        "pathway": " (hsa:1628);  (R-HSA-9931510)",
        "pathway_count": 2,
        "publication_count": 36,
        "publication_id_list": "10508692;10857746;11237011;14750904;17994337;18317514;1971514;20068231;24275569;26992070;28228285;28832583;28904123;29242379;29393594;29557506;29786170;30484775;31154438;31659740;31844290;32157095;32255717;32816832;32897882;32983136;33298915;33691108;33912179;35318648;36241625;36241641;36860124;7835883;8482542;8786133",
        "class_list": "",
        "function": "Expression of clock gene Dbp in omental and mesenteric adipose tissue in patients with type 2 diabetes., [RefSeq, PubMed]; N6-methyladenosine-modified DBT alleviates lipid accumulation and inhibits tumor progression in clear cell renal cell carcinoma through the ANXA2/YAP axis-regulated Hippo pathway., [RefSeq, PubMed]; Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; The Association Between VDR and GC Polymorphisms and Lung Cancer Risk: A Systematic Review and Meta-Analysis., [RefSeq, PubMed]; The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythm genes. [provided by RefSeq, Jul 2014]., [RefSeq]; This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation., [UniProtKB]; Vitamin D binding protein and risk of renal cell carcinoma in the prostate, lung, colorectal and ovarian cancer screening trial., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2I2P4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048511 rhythmic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "Q10586-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IZS7-1",
        "uniprot_id": "CLCL1_HUMAN",
        "mass": 19115.0,
        "length": 167,
        "protein_name": "C-type lectin-like domain family 1",
        "gene_name": "CLECL1",
        "organism": "Human",
        "refseq_name": "C-type lectin-like domain family 1 isoform 10",
        "refseq_ac": "NP_742001",
        "gene_names_uniprotkb": "CLECL1; CLECL1P; DCAL1",
        "gene_names_refseq": "CLECL1P; CLECL1; DCAL-1; DCAL1",
        "protein_names_uniprotkb": "C-type lectin-like domain family 1; DC-associated lectin-1; DCAL-1; Dendritic cell-associated lectin 1",
        "protein_names_refseq": "C-type lectin like 1, pseudogene; C-type lectin-like domain family 1 isoform 10; C-type lectin-like domain family 1 pseudogene; C-type lectin-like domain family 1; DC-associated lectin-1; dendritic cell-associated lectin 1; putative C-type lectin-like domain family 1; type II transmembrane protein DCAL1",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 17,
        "publication_id_list": "12421943;19027044;19648166;20237496;24715725;26992070;28832583;28834231;29242379;31154438;31844290;32983136;33691108;33936100;34932366;35051231;37938771",
        "class_list": "glycogene",
        "function": "C-type lectin-like molecule-1 is expressed in 86.5% of cases of acute myeloid leukemia, in 54.5% of acute myeloid leukemia CD34positiveCD38negative stem cells, but not in acute lymphoblastic leukemia blast cells., [RefSeq, PubMed]; DCAL-1, highly expressed on dendritic cells and B lymphocytes, acts as a T cell costimulatory molecule which skews CD4+ T cells toward a Th2 response by enhancing their secretion of IL-4., [RefSeq, PubMed]; Functions in mediating immune cell-cell interactions (PubMed:12421943, PubMed:19027044). Acts as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response. Expressed in immature dendritic cells, activates downstream signaling, incuding MAPK signaling pathway leading to an induction of the major histocompatibility complex (MHC) class II expression (PubMed:19027044)., [UniProtKB, PubMed, PubMed]; Incubation of immature DCs (iDCs) with an anti-DCAL-1 monoclonal antibody (mAb) induced downstream signaling, including phosphorylation of c-Jun N-terminal kinase (JNK) and p44/42 MAP kinase., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes a type II transmembrane, C-type lectin-like protein that is highly expressed on dendritic and B cells. This protein may act as a T-cell costimulatory molecule that enhances interleukin-4 production, and maybe involved in the regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0042102 positive regulation of T cell proliferation;GO:0032753 positive regulation of interleukin-4 production;GO:0097323 B cell adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q8IZS7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BZD4-1",
        "uniprot_id": "NUF2_HUMAN",
        "mass": 54304.0,
        "length": 464,
        "protein_name": "Kinetochore protein Nuf2",
        "gene_name": "NUF2",
        "organism": "Human",
        "refseq_name": "kinetochore protein Nuf2",
        "refseq_ac": "NP_113611",
        "gene_names_uniprotkb": "NUF2; CDCA1; NUF2R",
        "gene_names_refseq": "CDCA1; CT106; NUF2R; NUF2",
        "protein_names_uniprotkb": "Kinetochore protein Nuf2; Cell division cycle-associated protein 1; hNuf2R; hNuf2; hsNuf2",
        "protein_names_refseq": "NDC80 kinetochore complex component NUF2; NUF2, NDC80 kinetochore complex component, homolog; cancer/testis antigen 106; cell division cycle associated 1; cell division cycle-associated protein 1; hNuf2R; hNuf2; hsNuf2; kinetochore protein Nuf2",
        "tax_id": 9606,
        "disease": "oral cavity carcinoma in situ (Disease Ontology:DOID:0050610); castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); stomach cancer (Disease Ontology:DOID:10534); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:83540);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-5663220);  (R-HSA-68877);  (R-HSA-9648025)",
        "pathway_count": 8,
        "publication_count": 176,
        "publication_id_list": "10.1101/2023.09.13.557529;10411507;10600384;10678165;10958683;11081627;11181178;11237011;11266451;11371342;11509732;11535616;11685532;11804586;12006501;12194817;12429848;12438418;12577064;12679384;12732141;12805219;12852857;14602875;14654001;14699129;14730319;15006353;15062103;15085137;15235793;15239953;15339662;15507212;15548592;15723797;15737063;15864301;15866170;15944396;15961401;16292343;16439214;16541025;16565220;16622419;16622420;16682347;16890222;16943183;17030981;17112726;17113138;17129783;17196341;17198702;1737036;17535814;17924679;18001770;18097444;18669648;18716626;18923426;19007248;19350017;19415658;19691289;19696148;19815554;19965387;20030946;20068231;20101212;20591975;21111234;21148482;21397845;21576392;21868368;21878504;21987589;22094460;22275430;22608513;22790947;22885700;23085020;23186163;23222643;23481700;23801653;24397554;24606884;24714562;24715725;24914801;25418920;25576301;25645385;25740311;25789526;26154972;26728094;26811146;26929215;26992070;27600516;27846572;28228285;28498618;28649982;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29568993;29632046;29769354;29786170;30315122;30379171;30429286;30484775;30524438;30779550;30833945;31154438;31409757;31844290;31848261;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32897882;32938616;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34260926;34405274;34509645;34932366;35051231;35561310;35580925;35874702;36010968;36215666;36241641;37056930;37138262;37488294;37938771;39242581;9649308;9649503;9892021",
        "class_list": "",
        "function": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data highlight a specific role for hNuf2 in kinetochore-microtubule attachment and suggest that hNuf2 is part of a molecular linker between the kinetochore attachment site and tubulin subunits within the lattice of attached plus ends., [RefSeq, PubMed]; FOXM1 promotes neurofibromatosis type 1-associated malignant peripheral nerve sheath tumor progression in a NUF2-dependent manner., [RefSeq, PubMed]; Maintenance of magnesium homeostasis by NUF2 promotes protein synthesis and anaplastic thyroid cancer progression. Erratum:[Cell Death Dis. 2024 Nov 18;15(11):842. doi: 10.1038/s41419-024-07174-8. PMID: 39557824] Publication Status: Online-Only, [RefSeq, PubMed]; NUF2 Drives Cholangiocarcinoma Progression and Migration via Inhibiting Autophagic Degradation of TFR1. Publication Status: Online-Only, [RefSeq, PubMed]; NUF2 is correlated with a poor prognosis and immune infiltration in clear cell renal cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 10,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8WU69;Q96HJ4;Q96Q78",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008017 microtubule binding;GO:0044877 protein-containing complex binding",
        "go_cellular_component": "GO:0031262 Ndc80 complex;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0000776 kinetochore",
        "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051383 kinetochore organization;GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division",
        "synthesized_glycan_count": 0,
        "hit_score": 18.1,
        "record_id": "Q9BZD4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z3B4-1",
        "uniprot_id": "NUP54_HUMAN",
        "mass": 55435.0,
        "length": 507,
        "protein_name": "Nucleoporin p54",
        "gene_name": "NUP54",
        "organism": "Human",
        "refseq_name": "nucleoporin p54 isoform 2",
        "refseq_ac": "NP_001265532",
        "gene_names_uniprotkb": "NUP54",
        "gene_names_refseq": "DYT37; NUP54",
        "protein_names_uniprotkb": "Nucleoporin p54; 54 kDa nucleoporin",
        "protein_names_refseq": "54 kDa nucleoporin; nucleoporin 54kDa; nucleoporin 54kD; nucleoporin p54 isoform 2; nucleoporin p54",
        "tax_id": 9606,
        "disease": "dystonia 37, early-onset with striatal lesions (Disease Ontology:DOID:0060956)",
        "pathway": " (hsa:53371);  (R-HSA-1169408);  (R-HSA-159227);  (R-HSA-159230);  (R-HSA-159231);  (R-HSA-159236);  (R-HSA-165054);  (R-HSA-168271);  (R-HSA-168276);  (R-HSA-168325);  (R-HSA-168333);  (R-HSA-170822);  (R-HSA-180746);  (R-HSA-180910);  (R-HSA-1855170);  (R-HSA-1855196);  (R-HSA-1855229);  (R-HSA-191859);  (R-HSA-3108214);  (R-HSA-3232142);  (R-HSA-3301854);  (R-HSA-3371453);  (R-HSA-4085377);  (R-HSA-4551638);  (R-HSA-4570464);  (R-HSA-4615885);  (R-HSA-5619107);  (R-HSA-6784531);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9615933);  (R-HSA-9705671)",
        "pathway_count": 32,
        "publication_count": 459,
        "publication_id_list": "10205180;10228171;10323864;10444065;10489353;10526235;10531003;10556282;10574707;10601273;10601333;10668806;10725331;10759568;10827188;10846107;10851237;10862613;10911995;10920397;10931946;10954706;11014198;11073998;11095724;11112487;11118210;11124902;11157743;11231159;11231581;11237011;11256625;11259411;11259602;11289803;11333016;11451485;11455963;11502751;11514627;11579093;11709553;11714716;11727826;11739738;11747420;11748230;11756420;11788588;11792325;11836381;11871657;11889051;11909533;11932251;11960997;12003494;12019269;12027805;12032081;12065586;12072510;12093754;12095920;12121577;12138183;12149243;12196509;12228227;12393906;12441251;12525615;12526808;12582176;12589057;12692549;12711671;12729736;12747803;12759408;12776181;12802065;12832072;12853476;12857923;12917326;12974469;14516784;14578449;14627435;14701874;15082759;15109492;15120988;15131269;15161980;15175327;15199155;15208624;1531330;15317868;15355988;15364926;15378033;15485925;15574331;15592428;15608651;15702989;15731250;15802566;15823533;15829507;15831457;1586970;15931174;15940266;15959518;15989970;16009940;16030353;16112642;16122702;16139798;16140760;16194093;16278218;16314397;16352599;16361254;16407192;16428300;16478998;16608850;16608852;16626738;16688858;16699525;16710424;16715065;16775314;16810316;16815975;16872604;16914094;16933365;17000901;17018294;17081640;17098863;17132145;17183683;17204286;17224653;17235358;17289916;17317185;17376915;17412958;1754405;17690096;17693435;17698605;17705785;18203656;18226598;18235501;18235502;18287095;18305167;18316408;18364396;18381449;18394993;18408014;18411249;18423201;18452278;18535146;18550409;18583345;18625722;18628979;18691969;18708356;18809514;18946085;18984158;19073728;19125153;19229036;19270716;19287951;1944575;19494120;19596686;19622798;19640981;19682613;19706679;19779455;1985200;19914676;19956565;20016594;20016603;20068231;20098713;20129943;20133869;2017161;2017166;20190268;20219937;20300531;20305658;20308324;20351170;20385878;20417598;20630994;20663916;20705237;20797632;20797634;20953181;20972456;20974814;21098080;21147198;21167178;21284855;21300897;21311021;21335236;21450806;21550342;21554500;21559454;21593607;21647297;21690215;21740066;22121020;22174689;22402492;22424782;22457066;22464730;22465953;22493095;22508508;22541429;22544926;22635276;22661230;22732409;22735644;22751501;22825850;22893130;22940245;22941947;22944664;23092970;23299939;23301498;23349863;23481700;23582887;23750026;23804756;23826332;23871147;24002598;24027577;24068740;24366607;24369422;2470644;24782567;24870230;25114211;25218447;25391492;25576301;25602437;25640237;25704882;25723178;25849199;26572645;26992070;27068747;27501258;27655845;27846572;28228285;28415052;28510447;28514659;28649982;28832583;28834231;28855257;28904123;29242379;29331515;29351928;29393594;29493099;29508533;29557506;29632046;29632711;30315122;30355688;30360396;30379171;30397120;30429286;30524438;30761409;30779550;31217245;31844290;31850239;32119511;32157095;32265295;32350084;32353859;32357974;32387766;32428392;32488085;32502341;32589897;32726803;32728199;32897882;32938616;32938750;32953130;32979938;32983136;33024073;33060197;33097660;33110251;33214551;33298915;33349665;33360543;33372174;33372854;33396605;33440148;33479219;33495715;33514628;33537174;33567255;33592498;33717175;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33963333;33968037;33989516;33990585;34019948;34021074;34054808;34084167;34087483;34110168;34166398;34171305;34239064;34290717;34341353;34357683;34375313;34400613;34405274;34439781;34452305;34471099;34502139;34509645;34561969;34597346;34725712;34846842;34932366;35051231;35102342;35251023;35289036;35318648;35580925;35643212;36010968;36241641;36333996;37051252;37938771;38443362;38665916;39531497;40136647;40596516;40914422;41018975;6261960;6930639;7559393;7585962;7759547;7769657;7828588;7878053;7958838;8113738;8196654;8313914;8721986;8805303;8946918;9019411;9092824;9305631;9405152;9412458;9436978;9452416;9497385;9512417;9525617;9582382;9618489;9651582;9660920;9660949;9755184;9756909;9837918;9845364;9873016;9885291;9920933",
        "class_list": "",
        "function": "CircNUP54 promotes hepatocellular carcinoma progression via facilitating HuR cytoplasmic export and stabilizing BIRC3 mRNA. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Recessive NUP54 Variants Underlie Early-Onset Dystonia with Striatal Lesions., [RefSeq, PubMed]; The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 14,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 14,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 14,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 14,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCK7;B4DT35;Q96EA7;Q9NVL5;Q9P0I1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0017056 structural constituent of nuclear pore",
        "go_cellular_component": "GO:0005635 nuclear envelope;GO:0031965 nuclear membrane;GO:0044613 nuclear pore central transport channel;GO:0005643 nuclear pore",
        "go_biological_process": "GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:0051028 mRNA transport;GO:0036228 protein localization to nuclear inner membrane;GO:0006607 NLS-bearing protein import into nucleus",
        "synthesized_glycan_count": 0,
        "hit_score": 47.5,
        "record_id": "Q7Z3B4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96BN8-1",
        "uniprot_id": "OTUL_HUMAN",
        "mass": 40263.0,
        "length": 352,
        "protein_name": "Ubiquitin thioesterase otulin",
        "gene_name": "OTULIN",
        "organism": "Human",
        "refseq_name": "ubiquitin thioesterase otulin isoform 1",
        "refseq_ac": "NP_612357",
        "gene_names_uniprotkb": "OTULIN; FAM105B",
        "gene_names_refseq": "AIPDSA; AIPDS; FAM105B; GUM; IMD107; OTULIN",
        "protein_names_uniprotkb": "Ubiquitin thioesterase otulin; 3.4.19.12; Deubiquitinating enzyme otulin; OTU domain-containing deubiquitinase with linear linkage specificity; Ubiquitin thioesterase Gumby",
        "protein_names_refseq": "OTU domain-containing deubiquitinase with linear linkage specificity; deubiquitinating enzyme otulin; family with sequence similarity 105, member B; ubiquitin thioesterase Gumby; ubiquitin thioesterase otulin isoform 1; ubiquitin thioesterase otulin",
        "tax_id": 9606,
        "disease": "immunodeficiency 107 (Disease Ontology:DOID:0061076); autosomal dominant autoinflammation, panniculitis, and dermatosis syndrome (Disease Ontology:DOID:0061169); autoinflammation, panniculitis, and dermatosis syndrome (Disease Ontology:DOID:0061170); autosomal recessive autoinflammation, panniculitis, and dermatosis syndrome (Disease Ontology:DOID:0080163)",
        "pathway": " (hsa:90268);  (R-HSA-5357905);  (R-HSA-8866652)",
        "pathway_count": 3,
        "publication_count": 126,
        "publication_id_list": "10521396;10837247;11098060;11181075;11237011;11427719;11577081;12167698;12709429;14716293;15024054;15258597;15870263;16142244;16682944;16829951;16829952;17314102;17580310;17597759;17702576;18178551;18353650;19278658;19289468;19416807;19910467;20185725;20219915;20304918;20385093;21235526;21408173;22179575;22297296;22435550;22848449;23301498;23313255;23481700;23708998;23746843;23806334;23827681;24098568;24246475;24323043;24461064;24726323;24726327;25565632;25892735;26235645;26344099;26375851;26670046;26900751;26992070;26997266;27307491;27458237;27523608;27545878;27552911;27559085;27591049;27846572;27920218;28228285;28506461;28510447;28832583;28904123;28919039;28920952;28920954;29242379;29508533;29557506;29632711;29642005;29769354;30146158;30361438;30420664;30804083;30988283;31366726;31511692;31825842;31844290;32320653;32350084;32502341;32770022;32938616;32983136;33469115;33717175;33912179;33968037;33981976;34162724;34171305;34357683;34363755;34876703;35051231;35170849;35251023;35580925;35587511;35941131;38578307;38599290;38630025;38652464;6277905;6305978;7531702;7667287;7851534;8010951;9049422;9065443;9521656",
        "class_list": "",
        "function": "2.4 A and 2.8 A crystal structures of gumby (Fam105b) in the presence of free ubiquitin and linear diubiquitin substrate, respectively, [RefSeq, PubMed]; Cylindromatosis (CYLD) and OTULIN/Gumby/Fam105B, directly interact with the N-terminal PUB domain-containing region of HOIP., [RefSeq, PubMed]; Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:24726323, PubMed:24726327, PubMed:26997266, PubMed:27523608, PubMed:27559085, PubMed:28919039, PubMed:30804083, PubMed:35170849, PubMed:35587511, PubMed:38630025, PubMed:38652464). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (PubMed:23746843, PubMed:23806334). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:26670046). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent pro-inflammatory signaling (PubMed:23806334)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Downregulation of otulin induces inflammasome activation in neutrophilic asthma., [RefSeq, PubMed]; OTULIN Haploinsufficiency Causes Hyperinflammatory Responses to Infectious and Non-Infectious Triggers. Publication Status: Online-Only, [RefSeq, PubMed]; OTULIN restricts Met1-ubiquitin formation after immune receptor stimulation to prevent unwarranted proinflammatory signaling., [RefSeq, PubMed]; Reveal a previously unannotated human DUB, OTULIN (also known as FAM105B), which is exquisitely specific for Met1 linkages; data suggest that OTULIN regulates Met1-polyUb signaling., [RefSeq, PubMed]; This gene encodes a member of the peptidase C65 family of ubiquitin isopeptidases. Members of this family remove ubiquitin from proteins. The encoded enzyme specifically recognizes and removes M1(Met1)-linked, or linear, ubiquitin chains from protein substrates. Linear ubiquitin chains are known to regulate the NF-kappa B signaling pathway in the context of immunity and inflammation. Mutations in this gene cause a potentially fatal autoinflammatory syndrome in human patients. [provided by RefSeq, Sep 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 18,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DTD3;Q8NAS0;Q96IA3",
        "ec_number_list": "3.4.19.12;2.3.2.31",
        "go_molecular_function": "GO:0008234 cysteine-type peptidase activity;GO:0004843 cysteine-type deubiquitinase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0071797 LUBAC complex",
        "go_biological_process": "GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0006508 proteolysis;GO:0045087 innate immune response;GO:0050728 negative regulation of inflammatory response;GO:0016055 Wnt signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 12.9,
        "record_id": "Q96BN8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q17R98-1",
        "uniprot_id": "ZN827_HUMAN",
        "mass": 119165.0,
        "length": 1081,
        "protein_name": "Zinc finger protein 827",
        "gene_name": "ZNF827",
        "organism": "Human",
        "refseq_name": "zinc finger protein 827 isoform 1",
        "refseq_ac": "NP_001293144",
        "gene_names_uniprotkb": "ZNF827",
        "gene_names_refseq": "ZNF827",
        "protein_names_uniprotkb": "Zinc finger protein 827",
        "protein_names_refseq": "zinc finger protein 827 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:152485);  (R-HSA-9940951)",
        "pathway_count": 2,
        "publication_count": 52,
        "publication_id_list": "10204490;10970879;10978333;11237011;17646674;19240061;24554700;24715725;25114211;25150861;25218447;25576301;25593309;25645385;25755297;25772364;27633282;27732854;27846572;28218747;28514659;28904123;29042441;29242379;29351928;29437277;29557506;30045876;30134174;30379171;30410026;30418433;31746185;32157095;32357974;32488085;32502341;32938616;33141586;33174841;33298915;33592498;33912179;33968037;33981976;34387878;36008597;36010968;37938771;39894887;7969165;9512513",
        "class_list": "",
        "function": "As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Genome-wide association of individual vulnerability with alcohol-associated liver disease: A Korean genome and epidemiology study., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; RBBP4 forms a negatively charged channel that binds to ZNF827 through a network of electrostatic interactions. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZL52;Q7Z4S7;Q8N279",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0120325 NuRD complex binding;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:1990904 ribonucleoprotein complex;GO:0000781 chromosome, telomeric region",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0000723 telomere maintenance",
        "synthesized_glycan_count": 0,
        "hit_score": 5.7,
        "record_id": "Q17R98-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P27361-1",
        "uniprot_id": "MK03_HUMAN",
        "mass": 43136.0,
        "length": 379,
        "protein_name": "Mitogen-activated protein kinase 3",
        "gene_name": "MAPK3",
        "organism": "Human",
        "refseq_name": "mitogen-activated protein kinase 3 isoform 2",
        "refseq_ac": "NP_001035145",
        "gene_names_uniprotkb": "MAPK3; ERK1; PRKM3",
        "gene_names_refseq": "ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A; MAPK3; P44ERK1; P44MAPK; PRKM3; p44-ERK1; p44-MAPK",
        "protein_names_uniprotkb": "Mitogen-activated protein kinase 3; 2.7.11.24; ERK-1; ERT2; Extracellular signal-regulated kinase 1; Insulin-stimulated MAP2 kinase; MAP kinase 3; MAP kinase isoform p44; MAPK 3; Microtubule-associated protein 2 kinase; p44-ERK1; p44-MAPK",
        "protein_names_refseq": "MAPK 1; extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; insulin-stimulated MAP2 kinase; microtubule-associated protein 2 kinase; mitogen-activated protein kinase 3 isoform 2",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); withdrawal disorder (Disease Ontology:DOID:0060001); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); gastric ulcer (Disease Ontology:DOID:10808); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); colon adenocarcinoma (Disease Ontology:DOID:234); morphine dependence (Disease Ontology:DOID:2560); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometrial carcinoma (Disease Ontology:DOID:2871); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419); pulmonary hypertension (Disease Ontology:DOID:6432); cocaine abuse (Disease Ontology:DOID:809); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)",
        "pathway": " (hsa:5595);  (R-HSA-110056);  (R-HSA-112409);  (R-HSA-1169408);  (R-HSA-1181150);  (R-HSA-1295596);  (R-HSA-1502540);  (R-HSA-170968);  (R-HSA-198753);  (R-HSA-202670);  (R-HSA-2029482);  (R-HSA-2173795);  (R-HSA-2173796);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559585);  (R-HSA-2871796);  (R-HSA-3371453);  (R-HSA-375165);  (R-HSA-444257);  (R-HSA-445144);  (R-HSA-450341);  (R-HSA-456926);  (R-HSA-5654726);  (R-HSA-5654727);  (R-HSA-5654732);  (R-HSA-5654733);  (R-HSA-5663213);  (R-HSA-5668599);  (R-HSA-5673001);  (R-HSA-5674135);  (R-HSA-5674499);  (R-HSA-5675221);  (R-HSA-6802946);  (R-HSA-6802948);  (R-HSA-6802952);  (R-HSA-6802955);  (R-HSA-6811558);  (R-HSA-73728);  (R-HSA-74749);  (R-HSA-877300);  (R-HSA-879415);  (R-HSA-881907);  (R-HSA-8939211);  (R-HSA-8940973);  (R-HSA-8943724);  (R-HSA-9627069);  (R-HSA-9634638);  (R-HSA-9635465);  (R-HSA-9649948);  (R-HSA-9652169);  (R-HSA-9656223);  (R-HSA-9664422);  (R-HSA-9725371);  (R-HSA-9732724);  (R-HSA-9764725);  (R-HSA-9768919);  (R-HSA-982772);  (R-HSA-9842640);  (R-HSA-9856649)",
        "pathway_count": 60,
        "publication_count": 1152,
        "publication_id_list": "10022869;10026222;10067896;10072071;10102273;10197981;10199400;10206983;10207098;10209122;10219243;10224087;10347217;10358095;10393181;10395673;10400704;10409742;10415025;10427092;10432220;10455184;10473623;10480933;10485477;10485843;10490027;10496324;10508167;10521408;10523831;10531062;10531386;10535941;10542244;10548110;10549282;10559936;10567369;10567402;10587642;10587654;10588810;10611221;10611478;10617468;10629055;10655586;10655587;10673502;10702794;10722742;10724160;10725339;10747973;10757792;10772813;10781580;10818153;10822011;10822381;10831586;10869344;10871633;10878576;10878810;10887178;10891492;10934479;10949025;10954706;10986460;10995437;11007481;11007770;11013220;11024047;11027551;11027663;11053437;11090077;11090627;11095724;11106645;11112487;11114305;11117535;11136978;11145705;11145955;11150164;11157743;11157975;11162936;11169414;11231582;11234019;11237011;11238463;11243864;11250728;11274402;11276226;11278445;11278486;11279012;11294908;11297579;11306453;11313946;11325826;11329366;11340081;11340163;11340169;11378386;11389444;11389842;11408476;11424093;11427533;11463336;11466412;11478682;11485994;11545733;11545734;11546808;11553796;11564866;11585927;11698404;11702783;11726503;11741541;11747420;11747816;11751994;11779503;11779505;11781575;11782450;11788588;11795466;11802164;11802165;11804587;11829459;11840323;11854399;11875118;11883935;11889117;11891324;11912130;11912194;11930005;11959846;11972023;11988758;11997436;12032311;12040181;12040185;12055636;12056906;12063393;12068308;12070310;12093740;12094235;12105426;12110590;12118371;12121613;12134156;12150994;12189133;12189515;12193592;12213210;12231506;12235133;12356731;12391162;12391164;12419216;12421820;12435631;12438563;12446674;12456642;12470955;12473660;12479806;12493740;12525615;12526087;12529404;12582176;12583813;12586835;12592392;12593795;12593796;12620238;12627230;12670394;12672240;12676795;12700044;12700765;12716910;12743368;12748172;12808055;12814430;12815057;12832465;12832467;12853476;12904306;12907755;12915721;12917326;12917425;12935895;12943986;12974390;12974469;13130464;1314888;1319925;1325671;1396683;1411546;14506247;14507994;14530365;14532106;14586410;14605097;14615605;14636584;14654779;14657019;14676198;14679213;14701734;14707138;14718570;14722222;14724641;14729966;14765127;14970219;14975237;14978253;15031289;15035987;15040784;1508672;15087470;15090535;15094156;15100235;15118077;15118098;15123686;15131269;15143187;15150273;15150278;15226305;15239952;15260967;15271982;15287722;15314172;15322115;15324302;15350224;15356145;15364926;15388922;1540184;15452139;1545823;15485907;15485925;1549776;15507434;15520807;15526160;15530433;15531507;15542832;15543157;15546878;15547943;15548136;15548653;15563468;15564374;15564375;15572696;15580310;15591124;15597056;15616583;15630448;15637081;15657136;15664191;15702989;15705661;15774718;15788397;15802566;15820681;15824103;15851477;15866172;1586970;15897899;15952796;16009132;16009940;16014379;16025100;16034366;16099986;16102047;16112642;16122702;16135787;16139798;16140969;16153436;16156666;16186825;16199154;16211008;16237089;16260601;16262445;16278212;16278218;16319104;16329988;16337592;16352599;16364920;16393692;16407192;16418168;16428300;16436515;16456541;16467876;16479008;16484360;16497976;16507994;16508002;1651976;16546099;16580177;16581800;1660188;16626623;16627759;16636067;16641196;16676006;16684964;16699525;16702231;16702404;16702958;16715065;1672265;16751101;16751102;16751105;16762923;16764984;16775314;16778989;16809759;16814113;16815975;16822840;16826196;16835357;16872604;16879721;16880808;16892053;16893902;16914094;16939974;1698554;17018604;17081983;17097642;17110082;17111047;17125875;17130829;17145850;1716764;17178906;17188549;17192257;17200115;17202194;1720327;17208316;17210787;17253643;17254968;17255097;17255109;17272273;17274988;17289916;1730655;17308335;17322878;17332741;17344414;17344846;17376915;17389395;17395714;17416736;17438144;1748288;17496912;17510063;17540168;1754405;17563371;17583407;17591695;17592128;17603482;17603483;17615152;17623675;17690253;17724343;17765224;17825402;17873065;17873880;17875933;17906079;17922009;17974977;17993263;17998336;17998941;18024471;18060073;18070890;18083711;18097461;18166170;18172008;18222703;18235501;18235502;18267069;18287029;18287095;18294816;18296648;18305167;18332145;18347018;18362138;18365017;18391013;18391171;18391968;18411265;18413255;18435604;18451092;18452557;18477452;18487508;18488018;18515281;18547165;18550409;18555777;18555778;18555990;18559533;18562239;18568018;18577758;18583345;18591661;18632602;18644867;18669648;18691976;18707149;18775330;18785877;18793328;18794356;18813292;18951876;18974108;18983981;18985070;1898771;19060905;19073728;19091303;19091743;19114992;19124833;19125153;19135894;19158341;19219045;19229036;19242111;19265199;19270716;19274700;19279408;19369195;19372727;19389811;19412549;19440552;19447520;19451217;19451218;19462008;19467855;1948064;19494114;19524539;19528227;19565474;19574218;19576174;19592646;19608861;19651622;19652666;19690147;19690332;19696444;19715408;19741094;19801668;19805069;19884659;19901323;19909365;19914168;19914676;19917253;19920141;19927328;19933846;19955216;20015877;20049711;20052757;20068231;20117945;20130243;20130576;20133869;20141835;20179705;20219937;20226096;20233713;20304997;20308324;20332238;20351173;20353944;20358587;20363976;20379036;20385878;20418909;20429916;20452968;20454556;20460180;20463170;20478380;20485667;20493732;20509944;20516213;20526349;20534573;20595680;20670195;20674547;20686481;20694664;20813901;20818844;20858867;20871592;20877012;20956805;20957203;20977903;21037092;21095583;21102635;21107323;21129151;21173110;21187008;21210654;21239714;21289308;21356369;21368041;21372320;21383288;21383881;21406692;21419341;21424530;21486943;21514245;21532621;21639808;21715655;21779493;21779496;21779497;21779505;21784453;2183031;21884975;21965087;21979375;21986495;21993244;22020331;22031842;22043453;22045334;22065583;22096605;22113612;22128185;22158034;22177953;22178396;22197931;22223895;22275377;22275911;22292133;22325352;22336108;22347457;22356324;22393957;22395615;22465953;22510884;22541429;22569528;22589270;22634325;22647378;22683641;22730326;22735644;22745804;22750304;22808130;22815910;22826437;22909302;22940245;22955283;2295682;23056203;23061660;23086641;23103841;23105109;23159739;23171796;23186163;23190890;23207919;23287862;23288408;23289851;2330041;23303910;23349863;23352452;23353780;23375374;23403292;23443682;23453624;23466526;23575685;23583981;23614898;23620784;23667175;23675550;23680146;23684889;23686305;23727359;23846687;23850489;23875749;23875798;23934108;23954936;23977025;23980663;24039841;2405250;24060861;24065881;24071518;24121058;24135138;24202393;24241536;24265153;24288332;24291638;24300666;24345920;24367089;24376606;24417533;24465693;24521094;24651010;24706756;24718924;2474607;24746704;24810160;24825908;24853429;24897931;24937142;24957944;25049390;25179402;25182392;25187516;25195011;25204415;25219551;25221952;25248477;25261871;25303530;25313996;25314968;25435214;25468936;25500870;25576301;25595898;25597358;25597633;25645385;25728608;25728771;25733818;25780035;25781681;25818168;25849721;25865393;25877926;25907612;26043921;26046303;26085527;26153859;26154972;26212009;26214590;26279144;26379399;26400984;26580203;26610607;26716515;26910647;26919095;26945908;26967290;26983806;26992070;27054717;27119567;27128622;27134571;27153775;27227380;27304216;27472814;27503831;27533246;27542844;27553022;27557932;27558335;27698396;27797343;27846572;27920218;28012964;28076410;2809592;28218747;28228285;2825030;28387310;28394346;28481292;28514659;28598976;28771223;28778966;28832583;28834231;28848389;28915272;28939558;29154190;29242379;29295999;29368606;29393594;29412140;29435164;29437277;29467321;29493099;29508533;29557506;29577978;29588546;29602958;29605689;29615689;29632711;29729076;29766336;29786170;29789417;29986550;30015159;30034615;30315122;30484775;30692217;30779550;30794926;30804224;30853827;30853914;30898548;30986276;31116709;31135801;31154438;31196894;31366041;31390744;31434245;31530632;31612114;3167974;31844290;31848261;31910234;31936902;31998317;32051553;32157095;32188029;32316166;32350084;32357974;32488085;32502341;32636443;32639031;32872257;3287375;32897882;32938616;32983136;32998746;33072436;33101052;33114687;33141586;33171947;33239784;33298915;3349036;33537174;33608512;33633747;33686185;33717175;33744299;33828192;33912179;33936100;33968037;33981976;34140478;34185709;34211107;34497368;34819663;34932366;35008676;35051231;35138000;35216969;35292107;35580925;35851744;35939714;36010968;36284347;37770430;38725848;38885209;38902348;38993552;39197582;40914422;5338216;6148751;6201744;7510216;7514165;7530745;7535770;7559393;7565670;7565795;7585962;7588608;7588619;7588633;7615558;7617032;7651428;7657660;7673114;7687743;7689695;7690989;7691587;7731720;7739560;7784095;7796299;7806500;7809086;7816143;7848918;7855889;7859739;7889942;7891679;7892243;7906860;7929275;7935411;7935463;7958932;7972015;7984152;7997267;7997270;8001816;8013650;8051079;8052307;8078588;8089108;8156998;8157000;8176225;8180109;8188682;8196624;8221895;8226933;8232319;8234276;8259215;8290554;8319905;8325880;8327492;8336698;8343952;8349705;8384717;8386592;8387505;8388392;8394845;8413215;8413306;8483949;8493579;8509458;8529130;8530158;8550631;8552081;8592152;8617720;8622651;8622669;8622688;8626550;8626767;8631301;8635462;8641283;8663278;8665852;8673706;8688489;8702662;8702728;8710374;8721982;8721986;8741839;8774846;8794306;8809042;8816480;8846784;8878477;8884985;8939459;8939933;8946918;8974401;8982657;8986718;8995445;9020159;9030599;9030721;9032295;9042862;9048584;9058373;9087410;9099726;9111318;9115298;9143706;9155018;9162092;9182757;9182762;9183567;9195981;9199319;9199344;9199364;9264403;9288972;9295332;9305631;9311995;9346945;9353119;9396761;9440696;9446616;9448290;9459292;9480836;9525617;9529249;9560161;9560246;9564042;9600938;9604935;9618465;9628874;9639556;9670020;9676189;9677429;9687510;9702198;9705280;9707442;9730987;9733512;9760192;9768359;9799231;9804763;9817749;9824166;9843499;9858547;9873016;9883880;9885284;9915826;9920933;9924018;9927426;9930702;9973413;9989831",
        "class_list": "",
        "function": "Ciliogenesis-associated Kinase 1 Promotes Breast Cancer Cell Proliferation and Chemoresistance via Phosphorylating ERK1. Publication Status: Online-Only, [RefSeq, PubMed]; Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through ERK1/2 nuclear export., [RefSeq, PubMed]; Ferroptosis-related gene MAPK3 is associated with the neurological outcome after cardiac arrest. Publication Status: Online-Only, [RefSeq, PubMed]; MAZ promotes thyroid cancer progression by driving transcriptional reprogram and enhancing ERK1/2 activation., [RefSeq, PubMed]; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:34497368). MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DEPTOR, FRS2 or GRB10) (PubMed:35216969). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Phosphorylates GJA1 at 'Ser-279' and 'Ser-282' resulting in an increase in GJA1 ubiquitination and ultimately lysosomal degradation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 21,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8CZ58;B0LPG3;Q8NHX1",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.3.2.23;2.3.2.27;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;3.6.4.13;2.7.2.3;3.6.5.2;2.7.11.23;3.6.4.10;2.7.10.1;2.7.1.40;6.1.1.12;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;3.1.4.11;2.3.1.48;3.1.3.16;3.1.3.48;2.3.1.-;2.7.10.4;6.1.1.5;2.7.1.153;2.7.1.137;6.1.1.18;2.7.11.26;2.7.1.154;2.3.2.24;6.1.1.19;2.7.11.31;3.4.22.62;6.1.1.10;3.6.4.-;5.2.1.8;2.7.11.12;1.1.1.-;2.7.11.17;6.3.2.n3;2.7.11.8;2.7.7.-;6.1.1.6;5.3.99.3;2.7.11.19;4.1.1.32;2.7.1.107;2.7.1.94;2.7.1.138;3.6.5.-;2.7.7.19;1.14.11.65;3.1.31.1;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;6.1.1.4;2.3.2.-;2.3.2.26;3.4.19.12;2.7.1.150;2.3.2.31",
        "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0019902 phosphatase binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0072584 caveolin-mediated endocytosis;GO:2000641 regulation of early endosome to late endosome transport;GO:0070498 interleukin-1-mediated signaling pathway;GO:0006468 protein phosphorylation;GO:0007166 cell surface receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 115.5,
        "record_id": "P27361-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75376-1",
        "uniprot_id": "NCOR1_HUMAN",
        "mass": 270210.0,
        "length": 2440,
        "protein_name": "Nuclear receptor corepressor 1",
        "gene_name": "NCOR1",
        "organism": "Human",
        "refseq_name": "nuclear receptor corepressor 1 isoform 2",
        "refseq_ac": "NP_001177367",
        "gene_names_uniprotkb": "NCOR1; KIAA1047",
        "gene_names_refseq": "N-CoR1; N-CoR; NCOR1; PPP1R109; TRAC1; hN-CoR",
        "protein_names_uniprotkb": "Nuclear receptor corepressor 1; N-CoR1; N-CoR",
        "protein_names_refseq": "nuclear receptor corepressor 1 isoform 2; protein phosphatase 1, regulatory subunit 109; thyroid hormone- and retinoic acid receptor-associated corepressor 1",
        "tax_id": 9606,
        "disease": "polycystic ovary syndrome (Disease Ontology:DOID:11612); Huntington's disease (Disease Ontology:DOID:12858); hypothyroidism (Disease Ontology:DOID:1459); anxiety disorder (Disease Ontology:DOID:2030)",
        "pathway": " (hsa:9611);  (R-HSA-1251985);  (R-HSA-1989781);  (R-HSA-2122947);  (R-HSA-2151201);  (R-HSA-2173795);  (R-HSA-2644606);  (R-HSA-2894862);  (R-HSA-3214815);  (R-HSA-350054);  (R-HSA-381340);  (R-HSA-383280);  (R-HSA-400206);  (R-HSA-5617472);  (R-HSA-9022537);  (R-HSA-9022692);  (R-HSA-9029569);  (R-HSA-9609690);  (R-HSA-9623433);  (R-HSA-9707564);  (R-HSA-9707616);  (R-HSA-9841922);  (R-HSA-9931509);  (R-HSA-9933387);  (R-HSA-9976102)",
        "pathway_count": 25,
        "publication_count": 525,
        "publication_id_list": "10.1101/2023.09.13.557529;10075656;10197981;10198158;10199400;10206645;10235266;10381560;10412986;10425206;10444336;10444591;10449787;10485843;10494028;10529898;10531062;10535941;10542397;10549282;10558993;10587642;10587654;10643692;10713164;10713165;10748112;10777502;10777541;10835357;10858438;10879540;10882063;10882139;10904264;10922406;10926844;10964718;11006133;11013263;11027271;11044625;11095972;11112321;11149950;11226238;11237011;11267664;11330046;11340167;11387216;11389444;11427533;11461910;11500512;11509652;11533236;11585921;11604492;11679632;11739383;11740940;11742974;11779144;11809803;11865025;11872672;11875109;11909966;11931768;12032151;12032298;12050117;12118000;12130498;12150943;12177166;12209127;12213831;12354787;12356737;12374742;12374852;12377782;12391150;12454263;12505311;12511571;12530964;12563009;12582161;12590135;12612088;12724404;12745923;12807903;12829629;12857923;12969439;1310260;14525983;14527417;14572640;14703507;14764426;14980219;15023535;15067378;15107403;15130092;15147902;15175151;15175654;15273253;15302935;15322089;15454082;15534001;15546612;15574878;15635043;15665827;15684387;15760269;15761026;15820681;15824097;15829515;15850785;15867264;15896744;15919796;16024779;16061658;16079151;16079181;16079853;16093323;16140760;16156666;16256737;16380219;16476485;16503871;16530044;16530045;16549775;16568091;16738328;16751101;16751102;16751179;16788062;16871576;16890199;16908542;16911507;16912174;16964243;16972786;17003037;17007889;17011499;17018285;17031457;17046689;17081983;17114293;17157496;17185360;17186944;17211407;17264172;17306620;17322306;17401372;17428788;17437997;17438144;17452463;17510063;17519354;1756725;17591695;17592128;17646408;17646409;17660710;17713478;17715127;17761849;17761950;17851529;17923681;17980149;17994015;18006707;18037887;18043734;18077452;18094723;18203656;18212344;18215119;18220336;18288277;18292238;18296446;18343819;18374649;18452278;18535146;18540824;18568018;18653779;18669648;18680753;18691976;18719978;18767875;18781158;18782758;18824583;18824585;18848529;18931025;19001277;19043829;19047365;19088433;19115207;19115252;19135894;19151708;19172745;19225110;19232136;19289416;19331822;19356719;19413330;19417006;19481530;19524514;19596786;19608861;19651622;19664994;19664995;19682613;19690164;19690332;19710360;19710929;1971514;19726682;19747919;1975088;19782034;19820693;19854132;19917253;19934321;19951946;19968714;20058876;20068230;20068231;20085832;20101261;20110263;20112406;20466882;20466885;20494359;20543827;20566875;20581824;20812024;20817722;20855588;20929863;20972443;21095583;21187453;21310851;21406692;21479263;21507939;21587264;21628546;21690215;21889235;22045334;22174689;22381047;22427940;22541735;22569366;22673513;22675025;22705304;22879880;23129261;23186163;23219899;23230144;23239344;23301498;23372760;23481700;23496987;23519696;23534758;23630040;23669876;23770565;23770587;23790976;23911289;23940660;24174538;24196956;24275569;24308844;24312487;24586203;24714562;24715725;24829397;25101834;25114211;25135475;25218447;2539258;25418920;25505266;25576301;25645385;2570724;25772364;25880248;25913784;26101246;26154972;26239616;26374642;26375851;26572645;26984517;26992070;27071062;2713875;27153775;27397612;27501258;27655845;27754849;27846572;27920218;28082258;28111073;28415052;28657654;28698372;28698609;28832583;28834231;28842423;28869506;28904123;29237092;29242379;29351928;29393594;29493099;29508533;29557506;29577978;29632046;29632711;29772548;29786170;30059200;30360396;30379171;30410026;30620550;30761409;31217245;31492838;31637018;31748741;31844290;32119511;32157095;32354867;32357974;32387766;32488085;32502341;32574038;32695117;32897882;32938616;32938750;32983136;33141586;33214551;33298915;33329381;3345742;33592498;33691108;33717175;33912179;33936100;33968037;34019948;34171305;34185709;34211107;3427020;34357683;34405274;34561969;3475708;34846842;34932366;35044719;35051231;35132862;35138101;35251023;35254053;35289036;35318648;35494241;35513511;35580925;35705054;36010968;36241641;36284347;37340703;37541260;37802020;37909960;37938771;38359551;38665916;38814500;38838015;39302247;39531497;39534244;40136647;40307207;40596516;41350704;6094553;7488013;7501971;7513682;7566092;7588063;7629110;7685352;7799916;7831296;7892212;7906964;7908827;8001118;8060328;8108407;8156598;8325954;8333869;8386511;8402897;8415693;8521497;8521498;8622974;8643605;8647822;8649374;8674428;8687460;8706692;8759021;8770873;8887638;8970730;9012850;9062340;9065481;9079689;9144434;9150135;9171241;9178750;9218805;9244301;9272954;9286700;9315665;9328355;9454824;9462510;9482740;9604939;9620803;9620804;9651585;9651681;9653119;9694793;9724795;9744270;9748239;9790534;9819428;9836620",
        "class_list": "",
        "function": "Exploring TBL1XR1 and NCOR1 Expression in B-cell Lymphoma Subtypes: Interaction With DNA Damage Repair Genes., [RefSeq, PubMed]; GPS2 promotes erythroid differentiation in K562 erythroleukemia cells primarily via NCOR1., [RefSeq, PubMed]; Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver., [UniProtKB, UniProtKB, UniProtKB]; NCoR1 limits angiogenic capacity by altering Notch signaling., [RefSeq, PubMed]; Pulling rank with RNA: RANKL promotes the association of PGC-1beta/RNA complexes with NCoR/HDAC3 to activate gene expression in osteoclasts., [RefSeq, PubMed]; This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]., [RefSeq]; This paper describes the cloning of the full-length human NCOR1 cDNA., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 96,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 96,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 96,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 57,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 267,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 4,
        "glyco_site_count": 99,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3DLF8;E9PGV6;Q86YY0;Q9UPV5;Q9UQ18",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0000976 transcription cis-regulatory region binding;GO:0046966 nuclear thyroid hormone receptor binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0017053 transcription repressor complex",
        "go_biological_process": "GO:0045922 negative regulation of fatty acid metabolic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0006325 chromatin organization",
        "synthesized_glycan_count": 0,
        "hit_score": 62.8,
        "record_id": "O75376-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P51793-1",
        "uniprot_id": "CLCN4_HUMAN",
        "mass": 84917.0,
        "length": 760,
        "protein_name": "H(+)/Cl(-) exchange transporter 4",
        "gene_name": "CLCN4",
        "organism": "Human",
        "refseq_name": "H(+)/Cl(-) exchange transporter 4 isoform 2",
        "refseq_ac": "NP_001243873",
        "gene_names_uniprotkb": "CLCN4",
        "gene_names_refseq": "CLC4; CLCN4; ClC-4A; ClC-4; MRX15; MRX49; MRXSRC",
        "protein_names_uniprotkb": "H(+)/Cl(-) exchange transporter 4; Chloride channel protein 4; Chloride transporter ClC-4; ClC-4",
        "protein_names_refseq": "H(+)/Cl(-) exchange transporter 4 isoform 2; chloride channel 4; chloride channel protein 4; chloride channel, voltage-sensitive 4; chloride transporter ClC-4; chloride voltage-gated channel 4; h(+)/Cl(-) exchange transporter 4",
        "tax_id": 9606,
        "disease": "Dent disease (Disease Ontology:DOID:0050699); low molecular weight proteinuria with hypercalciuric nephrocalcinosis (Disease Ontology:DOID:0111815); Raynaud-Claes syndrome (Disease Ontology:DOID:0112060); spondylometaphyseal dysplasia (Disease Ontology:DOID:0112295); osteopetrosis (Disease Ontology:DOID:13533)",
        "pathway": " (hsa:1183);  (R-HSA-2672351)",
        "pathway_count": 2,
        "publication_count": 111,
        "publication_id_list": "10564087;10642508;10720933;10767424;10830164;10831588;11182090;11237011;11588175;11687798;11734858;11842292;11904445;11956057;12393854;12907679;1379744;14584882;14634667;15010458;15044642;15147738;15318163;15504734;15505377;15916532;15919655;16219661;16813530;16849430;16850186;17023393;17381423;17448995;17699613;17881003;18000046;18063579;18310267;18400985;18449189;18508966;18662336;18724360;19153159;19307298;19380724;19387438;19620632;19808995;19953639;20388639;20466723;20525693;20538786;21040849;21527911;21984732;22002868;22773952;22946059;2298749;23112050;2321095;23616951;23647072;24715725;2536303;25644381;26034137;26359375;26562072;26811146;27550844;27862975;28071645;28154142;28790369;28972156;29557506;29845874;30418433;31154438;32350084;32983136;33592498;33951195;33968037;34357683;35051231;36284347;36385166;38578438;7588753;7665160;7795595;8041726;8069296;8112288;8383669;8533761;8544406;8626462;8809036;9037075;9395096;9571199;9662395;9700209;9719863;9744806",
        "class_list": "",
        "function": "Functional and clinical studies reveal pathophysiological complexity of CLCN4-related neurodevelopmental condition., [RefSeq, PubMed]; Genotype-phenotype correlation in CLCN4-related developmental and epileptic encephalopathy., [RefSeq, PubMed]; Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:18063579, PubMed:23647072, PubMed:25644381, PubMed:27550844, PubMed:28972156). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:29845874). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (PubMed:29845874)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012]., [RefSeq]; The molecular and phenotypic spectrum of CLCN4-related epilepsy., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L3U1;B7Z5Z4;Q9UBU1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0015297 antiporter activity;GO:0005247 voltage-gated chloride channel activity;GO:0005254 chloride channel activity",
        "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0005765 lysosomal membrane",
        "go_biological_process": "GO:0034220 monoatomic ion transmembrane transport;GO:0006821 chloride transport;GO:1905515 non-motile cilium assembly;GO:0006811 monoatomic ion transport",
        "synthesized_glycan_count": 0,
        "hit_score": 11.2,
        "record_id": "P51793-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92989-1",
        "uniprot_id": "CLP1_HUMAN",
        "mass": 47646.0,
        "length": 425,
        "protein_name": "Polyribonucleotide 5'-hydroxyl-kinase Clp1",
        "gene_name": "CLP1",
        "organism": "Human",
        "refseq_name": "polyribonucleotide 5'-hydroxyl-kinase Clp1 isoform 2",
        "refseq_ac": "NP_001136069",
        "gene_names_uniprotkb": "CLP1; HEAB",
        "gene_names_refseq": "CLP1; HEAB; hClp1",
        "protein_names_uniprotkb": "Polyribonucleotide 5'-hydroxyl-kinase Clp1; 2.7.1.78; Polyadenylation factor Clp1; Polynucleotide kinase Clp1; Pre-mRNA cleavage complex II protein Clp1",
        "protein_names_refseq": "ATP/GTP-binding protein; cleavage and polyadenylation factor I subunit 1; homolog of yeast CFIA subunit Clp1p; polyadenylation factor Clp1; polynucleotide kinase Clp1; polyribonucleotide 5'-hydroxyl-kinase Clp1 isoform 2; polyribonucleotide 5'-hydroxyl-kinase Clp1; pre-mRNA cleavage complex II protein Clp1",
        "tax_id": 9606,
        "disease": "pontocerebellar hypoplasia type 10 (Disease Ontology:DOID:0060279)",
        "pathway": " (hsa:10978);  (R-HSA-6784531);  (R-HSA-72187);  (R-HSA-73856);  (R-HSA-77595);  (R-HSA-9770562);  (R-HSA-9918481)",
        "pathway_count": 7,
        "publication_count": 129,
        "publication_id_list": "10444065;10669729;11060040;11237011;11455963;11727826;11747608;11871657;11979277;12138183;12526808;12711671;12729736;12871933;14519844;14749727;14762106;15037765;15084397;15109492;15317868;15565158;15998806;16361254;16710424;17128255;17190602;17204286;17224653;17495927;17984224;18077418;18226598;18288197;18411249;18648070;18809514;18957205;18984158;19217410;19836239;20573985;20695905;20844015;21295486;21311021;21450806;21559454;21593607;21911577;21947206;22207203;22813749;22928037;22944664;23222130;23299939;23481700;23874216;24076191;24149845;24244187;2470644;24714562;24715725;24766809;24766810;24870230;25301780;25301781;25576301;25640237;25662211;25836925;25849199;26092250;26375851;26992070;27108190;27600516;27846572;27920218;28096519;28467828;28832583;28834231;28911096;29186539;29242379;29274231;29557506;29786170;29902443;30139799;30257008;30315122;30599162;30779550;31530632;31844290;31848261;32157095;32161166;32488085;32816001;32938616;33141586;33177556;33298915;33592498;33717175;33936100;33968037;33981976;34185709;34211107;34273619;35051231;35177536;35215846;36215666;39894887;6930639;7759547;7828588;8896421;9512417;9659921;9660920",
        "class_list": "",
        "function": "Expression of hClp1 in budding yeast can complement conditional and lethal mutations in the essential 5'-OH RNA kinase module of yeast or plant tRNA ligases., [RefSeq, PubMed]; HEAB is a pre-mRNA 3'-end processing factor, which bridges two other pre-mRNA processing factors (CF Im and CPSF) and is involved in cleavage of the pre-mRNA. It can be UV-crosslinked to GTP., [RefSeq, PubMed]; Modeling a human CLP1 mutation in mouse identifies an accumulation of tyrosine pre-tRNA fragments causing pontocerebellar hypoplasia type 10., [RefSeq, PubMed]; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing., [UniProtKB, HAMAP, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The kinase hClp1 phosphorylates and licenses synthetic siRNAs to become assembled into RISC for subsequent target RNA cleavage, [RefSeq, PubMed]; This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R7J6;B4DTI8",
        "ec_number_list": "3.6.4.13;3.6.4.10;3.1.13.-;2.7.7.48;2.7.7.6;2.7.7.19;3.1.3.16;3.1.3.53;2.7.1.78;2.3.2.27;4.6.1.16;5.2.1.8;3.1.3.32;2.7.7.52;3.1.27.-",
        "go_molecular_function": "GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0051736 ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity;GO:0005524 ATP binding;GO:0051731 polynucleotide 5'-hydroxyl-kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005849 mRNA cleavage factor complex;GO:0000214 tRNA-intron endonuclease complex",
        "go_biological_process": "GO:0070922 RISC complex assembly;GO:0021695 cerebellar cortex development;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0000379 tRNA-type intron splice site recognition and cleavage;GO:0031124 mRNA 3'-end processing",
        "synthesized_glycan_count": 0,
        "hit_score": 13.2,
        "record_id": "Q92989-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TBZ3-1",
        "uniprot_id": "WDR20_HUMAN",
        "mass": 62893.0,
        "length": 569,
        "protein_name": "WD repeat-containing protein 20",
        "gene_name": "WDR20",
        "organism": "Human",
        "refseq_name": "WD repeat-containing protein 20 isoform 4",
        "refseq_ac": "NP_001229343",
        "gene_names_uniprotkb": "WDR20",
        "gene_names_refseq": "Bun107; DMR; WDR20",
        "protein_names_uniprotkb": "WD repeat-containing protein 20; Protein DMR",
        "protein_names_refseq": "WD repeat-containing protein 20 isoform 4; WD repeat-containing protein 20",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91833);  (R-HSA-5689880)",
        "pathway_count": 2,
        "publication_count": 95,
        "publication_id_list": "10444327;10982817;11237011;11566882;11923872;12917689;12917691;14661020;15053880;15916963;16214042;16901786;16964248;17290220;17443180;17873522;17980597;17981138;18172164;18467330;18632802;18636086;18669648;18767875;19015242;19135894;19188362;19363159;19398555;19424180;19651622;19664995;19690332;19838211;19874889;19910467;20068231;20096447;20147737;20228808;20368735;20501646;21239494;21362556;21406692;21571647;21596315;21659512;21849505;21962518;22029577;22085928;22128162;22216260;23159851;23186163;23395819;23486064;23824326;23825189;24056413;24260525;24493797;24714562;24896179;25197364;25305019;25418920;25576301;25578727;25892735;26728094;26992070;27373336;27846572;28904123;29557506;29786170;30410026;30466959;31844290;32157095;32357974;32488085;32938616;33717175;33844468;33912179;33968037;34087483;35051231;35580925;36581221;39432777;7578059",
        "class_list": "",
        "function": "Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336). Regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus (PubMed:30466959)., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]., [RefSeq]; WDR20 prevents hepatocellular carcinoma senescence by orchestrating the simultaneous USP12/46-mediated deubiquitination of c-Myc., [RefSeq, PubMed]; WDR20 serves as a stimulatory subunit for preserving and regulating the activity of the subset of the UAF1 x USP12 complexes, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DN18;E7EUY8;F8W9S4;G3V2F8;G3V5R0;H0YJJ1;Q86TU2;Q8NCN7;Q8WXX2;Q9UF86",
        "ec_number_list": "",
        "go_molecular_function": "GO:0035800 deubiquitinase activator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.6,
        "record_id": "Q8TBZ3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q2HXU8-1",
        "uniprot_id": "CL12B_HUMAN",
        "mass": 31616.0,
        "length": 276,
        "protein_name": "C-type lectin domain family 12 member B",
        "gene_name": "CLEC12B",
        "organism": "Human",
        "refseq_name": "C-type lectin domain family 12 member B isoform 1",
        "refseq_ac": "NP_001123470",
        "gene_names_uniprotkb": "CLEC12B; PRO16089",
        "gene_names_refseq": "CLEC12B; UNQ5782",
        "protein_names_uniprotkb": "C-type lectin domain family 12 member B; Macrophage antigen H",
        "protein_names_refseq": "C-type lectin domain family 12 member B isoform 1; macrophage antigen h; testis secretory sperm-binding protein Li 205a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:387837)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;12975309;17562706;29557506;30350915;32938616;34020140;34310951;34780782;34896119;35494241",
        "class_list": "glycogene",
        "function": "CLEC12B Decreases Melanoma Proliferation by Repressing Signal Transducer and Activator of Transcription 3., [RefSeq, PubMed]; CLEC12B Is a Melanocytic Gene Regulating the Color of the Skin., [RefSeq, PubMed]; CLEC12B is an inhibitory receptor on myeloid cells, [RefSeq, PubMed]; CLEC12B suppresses lung cancer progression by inducing SHP-1 expression and inactivating the PI3K/AKT signaling pathway., [RefSeq, PubMed]; Inhibitory receptor postulated to negatively regulate immune and non-immune functions (PubMed:17562706, PubMed:34310951). Upon phosphorylation, recruits SH2 domain-containing PTPN6 and PTPN11 phosphatases to its ITIM motif and antagonizes activation signals (PubMed:17562706, PubMed:34310951). Although it inhibits KLRK1/NKG2D-mediated signaling, it does not bind known ligands of KLRK1/NKG2D and therefore is not its inhibitory counterpart (PubMed:17562706). May limit activation of myeloid cell subsets in response to infection or tissue inflammation (PubMed:17562706). May protect target cells against natural killer cell-mediated lysis (PubMed:17562706). May negatively regulate cell cycle and differentiation of melanocytes via inactivation of STAT3 (PubMed:34310951)., [UniProtKB, PubMed, PubMed]; Selective expression of a C-type lectin receptor, Clec12b, on skin mast cells. Erratum:[Biochem Biophys Res Commun. 2021 Sep 3;568:193-194. doi: 10.1016/j.bbrc.2021.07.009. PMID: 34246465], [RefSeq, PubMed]; We identified a potential deleterious, missense mutation in CLEC12B in two children affected by ganglioneuroma and neuroblastoma, [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 352,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6UWF2;Q6ZRG0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030547 signaling receptor inhibitor activity;GO:0030246 carbohydrate binding;GO:0019903 protein phosphatase binding;GO:0030545 signaling receptor regulator activity",
        "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0032991 protein-containing complex;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0002769 natural killer cell inhibitory signaling pathway;GO:2000272 negative regulation of signaling receptor activity;GO:0097325 melanocyte proliferation;GO:0045953 negative regulation of natural killer cell mediated cytotoxicity;GO:1904893 negative regulation of receptor signaling pathway via STAT",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q2HXU8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6IQ26-1",
        "uniprot_id": "DEN5A_HUMAN",
        "mass": 147096.0,
        "length": 1287,
        "protein_name": "DENN domain-containing protein 5A",
        "gene_name": "DENND5A",
        "organism": "Human",
        "refseq_name": "DENN domain-containing protein 5A isoform 2",
        "refseq_ac": "NP_001230183",
        "gene_names_uniprotkb": "DENND5A; KIAA1091; RAB6IP1",
        "gene_names_refseq": "DEE49; DENND5A; EIEE49; RAB6IP1",
        "protein_names_uniprotkb": "DENN domain-containing protein 5A; Rab6-interacting protein 1; Rab6IP1",
        "protein_names_refseq": "DENN domain-containing protein 5A isoform 2; DENN domain-containing protein 5A; DENN/MADD domain containing 5A; RAB6 interacting protein 1; rab6-interacting protein 1",
        "tax_id": 9606,
        "disease": "developmental and epileptic encephalopathy 49 (Disease Ontology:DOID:0080441)",
        "pathway": " (hsa:23258);  (R-HSA-8876198)",
        "pathway_count": 2,
        "publication_count": 242,
        "publication_id_list": "10.1038/emboj.2013.79;10818110;10990452;11038176;11179213;11237011;11516400;11689439;11703925;11746448;11784320;11917121;12058051;12221131;12244319;12364329;12427552;12475894;12684051;12944476;12972505;15096524;15138286;1516130;15247254;15388334;15528189;15561770;15692570;15878329;15914536;15958533;16207721;16373702;16410077;16525024;16525121;16571673;16641372;16754960;16880209;16950109;17043139;17081983;17132146;17189207;17208202;17239822;17287728;17488286;17562788;17574030;17646400;17671165;17678623;18076383;18094055;18354496;18367545;1845915;18477474;18559336;18585354;18664496;18669648;18701652;18779367;18804435;1900457;19109890;19141279;19345684;19403694;19490898;19620288;19656848;19725050;19729655;19745841;20008558;20058876;20154091;20159109;20159556;20305638;20308558;20404108;20434987;20592283;20797862;20851765;20937701;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21951725;22013193;22065758;22072793;22171327;22365832;22433857;22511774;22558185;22581368;22595670;22622570;22648168;22653444;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23186163;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23584533;23645161;23678941;23684622;23713133;23839779;24296415;24644286;24694596;24719330;24891604;24917561;24967941;25074980;25341920;25343031;25472813;25645385;25648148;25713415;25892735;25925668;26055712;26177209;26245486;26434594;26538022;26811146;26925400;26936971;27041585;27044746;27103185;27246931;27329675;27397612;27431290;27600516;27866705;27920218;28218747;28649982;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29557506;29769354;30315122;30484775;30524438;30779550;30833945;31154438;31844290;31848261;31998317;32157095;32161166;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33717175;33968037;34509645;34561969;34906508;35051231;35154160;35580925;36010968;36241641;36284347;37938771;39174524;7688123;7911226;8144603;8408203;8522602;8863739;9020086;9020161;9030515;9136770;9323142;9590177;9733780",
        "class_list": "",
        "function": "A RUN Domain from DENND5/Rab6IP1 binds sorting Nexin 1 and is involved in the trafficking of vesicles at the level of Golgi., [RefSeq, PubMed]; Crystal structure of Rab6a(GTP) in complex with a 378-residue internal fragment of the effector Rab6IP1 was solved at 3.2 angstroms resolution. This Rab6IP1 region encompasses an all alpha-helical RUN domain followed in tandem by a PLAT domain, [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity)., [UniProtKB, PubMed, UniProtKB]; Identification of an epileptic encephalopathy additionally featuring cerebral calcifications and coarse facial features caused by recessive loss-of-function mutations in DENND5A, [RefSeq, PubMed]; Loss of symmetric cell division of apical neural progenitors drives DENND5A-related developmental and epileptic encephalopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Novel loss-of-function variant in DENND5A impedes melanosomal cargo transport and predisposes to familial cutaneous melanoma., [RefSeq, PubMed]; This gene encodes a DENN-domain-containing protein that functions as a RAB-activating guanine nucleotide exchange factor (GEF). This protein catalyzes the conversion of GDP to GTP and thereby converts inactive GDP-bound Rab proteins into their active GTP-bound form. The encoded protein is recruited by RAB6 onto Golgi membranes and is therefore referred to as RAB6-interacting protein 1. This protein binds with RAB39 as well. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene are associated with early infantile epileptic encephalopathy-49. [provided by RefSeq, Feb 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DJ15;E9PS91;Q96GN3;Q9H6U7;Q9UFV0;Q9UPR1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005802 trans-Golgi network;GO:0016020 membrane",
        "go_biological_process": "GO:0010977 negative regulation of neuron projection development;GO:0042147 retrograde transport, endosome to Golgi",
        "synthesized_glycan_count": 0,
        "hit_score": 24.7,
        "record_id": "Q6IQ26-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43237-1",
        "uniprot_id": "DC1L2_HUMAN",
        "mass": 54099.0,
        "length": 492,
        "protein_name": "Cytoplasmic dynein 1 light intermediate chain 2",
        "gene_name": "DYNC1LI2",
        "organism": "Human",
        "refseq_name": "cytoplasmic dynein 1 light intermediate chain 2 isoform 2",
        "refseq_ac": "NP_001273086",
        "gene_names_uniprotkb": "DYNC1LI2; DNCLI2; LIC2",
        "gene_names_refseq": "DNCLI2; DYNC1LI2; LIC2",
        "protein_names_uniprotkb": "Cytoplasmic dynein 1 light intermediate chain 2; Dynein light intermediate chain 2, cytosolic; LIC-2; LIC53/55",
        "protein_names_refseq": "LIC-2; LIC53/55; cytoplasmic dynein 1 light intermediate chain 2 isoform 2; cytoplasmic dynein 1 light intermediate chain 2; dynein light intermediate chain 2, cytosolic; dynein, cytoplasmic, light intermediate polypeptide 2",
        "tax_id": 9606,
        "disease": "essential fructosuria (Disease Ontology:DOID:0111680)",
        "pathway": " (hsa:1783);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-2132295);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-3371497);  (R-HSA-5663220);  (R-HSA-6807878);  (R-HSA-6811436);  (R-HSA-68877);  (R-HSA-9609690);  (R-HSA-9646399);  (R-HSA-9648025)",
        "pathway_count": 14,
        "publication_count": 417,
        "publication_id_list": "10036229;10052452;10064083;10072072;10089880;10318838;10359595;10411507;10445031;10480952;10491388;10540230;10559959;10559986;10562278;10593899;10600384;10631941;10631952;10639150;10678165;10679020;10747884;10748235;10761932;10809954;10903204;10921873;10958683;11035033;11080672;11081627;11172815;11181178;11237011;11285137;11306556;11371342;11461920;11483508;11509732;11529500;11535616;11589254;11684289;11689559;11701661;11703931;11726511;11748249;11751894;11790530;11804586;11813165;11853874;12006501;12024216;12047556;12070132;12078484;12194817;12198549;12388752;12401177;12429848;12432908;12447383;12577064;12634853;12679384;12732141;12742663;12748383;12781197;12805219;12852857;12857923;12925777;13486053;14654841;14675537;14730319;14731593;14742712;1493716;15006353;15037235;15085137;15159550;15339662;15381148;15483056;15507212;15591061;15616190;15632110;15723797;15728195;15737063;15749704;15813748;15864301;15866170;15878873;15911768;15914536;15944396;16030262;16140760;16181339;16207721;16242130;16292343;1631136;16314391;16403413;16439214;16541025;16618111;16622419;16622420;16633337;16682347;16723730;1680566;16824007;16890222;16912714;16926190;16940185;16943183;16964243;17030981;17081983;17112726;17113138;17129783;17142755;17196341;17198702;17253781;17274799;17283181;17322306;17360540;1737036;17429068;17451557;17488286;17591767;17760859;17785525;17804755;17827179;17846173;17927562;17956946;18001770;18046453;18086915;18097444;18182008;18203656;18215318;18243712;18254226;18283113;18292509;18452278;18524849;18535146;18635947;18641641;18664496;18669648;18691976;18716626;18767875;18809720;18923426;1898986;19015319;19109418;19164740;19296914;19350017;19359544;19413330;19415658;1956401;19564404;1957170;19631211;19635840;19651622;19664994;19664995;19682613;19696148;19753100;19758564;19815554;19965387;20006655;20030946;20038533;20068231;20072699;20101212;20357002;20420828;20427317;20591975;20637885;21111234;21116285;21148482;21158691;21173190;21183720;2121367;21219331;21376746;21397845;21406692;21441454;21576392;21689688;21690215;21700222;21796517;21844168;21868368;21878504;2190094;21987589;22011577;22013193;22094269;22094460;22130221;22174689;22266222;22275430;22304919;22318716;22433123;22562055;22608513;22790947;22791416;22885700;23186163;23222643;23301498;23333653;23481700;23515720;23783758;23801653;23839779;2391366;24012426;24119662;24129315;24200693;24694367;24806965;24891604;24914801;25233431;25436559;25453831;25492864;25576301;25645385;25740311;25789526;26073023;26154972;26203193;26313416;26572645;26992070;27462449;27501258;27600516;27663436;27846572;27862975;28083797;28301631;28415052;28755533;28904123;28919297;29420470;29485866;29557506;30197098;30360396;30761409;31110491;31141847;31154438;31409757;31731497;31826031;31844290;32016915;32157095;32320027;32350084;32357974;32387766;32448030;32467330;32488085;32502341;32544881;32897882;32938616;32982970;32983136;33141586;33298915;33537174;33592498;33968037;33981976;34019948;34087483;34211107;34260926;34357683;34405274;34509645;34643468;35051231;35132862;35251023;35318648;35580925;36010968;36071160;36215666;36241641;36284347;37938771;38665916;39302247;40596516;40914422;6645495;6891012;7481823;7592972;7650016;7667286;7691276;8001155;8046351;8128252;8132710;8134367;8145819;8148318;8157723;8221884;8253837;8282004;8313912;8397411;8415765;8505331;8560673;8620540;8636227;8642258;8687433;8849454;8909537;8939989;8947036;8991093;9030515;9050864;9075930;9114004;9150144;9177194;9202021;9244307;9288971;9311912;9312039;9323141;9380700;9382863;9405360;9464360;9464361;9490716;9497313;9539769;9545226;9606180;9649308;9649503;9667968;9671725;9671731;9733780;9751720;9864362;9892021;9990005",
        "class_list": "",
        "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Cytoplasmic dynein is a microtubule-associated motor protein (Hughes et al., 1995 [PubMed 7738094]). See DYNC1H1 (MIM 600112) for general information about dyneins.[supplied by OMIM, Mar 2008]., [RefSeq]; DYNC1LI2 regulates localization of the chaperone-mediated autophagy receptor LAMP2A and improves cellular homeostasis in cystinosis., [RefSeq, PubMed]; Transgelin-2 and phosphoregulation of the LIC2 subunit of dynein govern mitotic spindle orientation. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K6V1;B4DZP4;Q8TAT3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0045504 dynein heavy chain binding",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0016020 membrane;GO:0005770 late endosome",
        "go_biological_process": "GO:1990090 cellular response to nerve growth factor stimulus;GO:0007018 microtubule-based movement;GO:0000226 microtubule cytoskeleton organization;GO:0032388 positive regulation of intracellular transport",
        "synthesized_glycan_count": 0,
        "hit_score": 42.0,
        "record_id": "O43237-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96HH9-1",
        "uniprot_id": "GRM2B_HUMAN",
        "mass": 47869.0,
        "length": 432,
        "protein_name": "GRAM domain-containing protein 2B",
        "gene_name": "GRAMD2B",
        "organism": "Human",
        "refseq_name": "GRAM domain-containing protein 2B isoform 1",
        "refseq_ac": "NP_001139791",
        "gene_names_uniprotkb": "GRAMD2B; GRAMD3; NS3TP2",
        "gene_names_refseq": "GRAMD2B; GRAMD3; NS3TP2",
        "protein_names_uniprotkb": "GRAM domain-containing protein 2B; HCV NS3-transactivated protein 2",
        "protein_names_refseq": "GRAM domain containing 3; GRAM domain-containing protein 2B isoform 1; GRAM domain-containing protein 2B; GRAM domain-containing protein 3; HCV NS3-transactivated protein 2; hepatitis C virus nonstructural protein 3-transactivating protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:65983)",
        "pathway_count": 1,
        "publication_count": 42,
        "publication_id_list": "11237011;17081983;18220336;18452278;18669648;19651622;19664994;20068231;24715725;25576301;27846572;27920218;28228285;29242379;29393594;29557506;29786170;29789417;30315122;30429286;30484775;31154438;31844290;31848261;31937595;32157095;32387766;32502341;32938616;33141586;33298915;33968037;34171305;34211107;34509645;34932366;35051231;35318648;35580925;36215666;36241641;37938771",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 15,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z1F2;B7Z3R1;B7Z6D8;B7Z8T2;D3DSZ3;Q9H753",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005881 cytoplasmic microtubule;GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "Q96HH9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q49AR2-1",
        "uniprot_id": "CE022_HUMAN",
        "mass": 49967.0,
        "length": 442,
        "protein_name": "UPF0489 protein C5orf22",
        "gene_name": "C5orf22",
        "organism": "Human",
        "refseq_name": "UPF0489 protein C5orf22",
        "refseq_ac": "NP_060826",
        "gene_names_uniprotkb": "C5orf22",
        "gene_names_refseq": "C5orf22",
        "protein_names_uniprotkb": "UPF0489 protein C5orf22",
        "protein_names_refseq": "UPF0489 protein C5orf22",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55322)",
        "pathway_count": 1,
        "publication_count": 42,
        "publication_id_list": "11237011;18669648;19413330;23301498;25418920;25576301;26154972;26992070;27600516;28063628;28218747;28228285;28446606;28832583;28834231;29242379;29393594;29437277;29557506;29632046;30379171;30410026;30429286;31217245;31844290;31846293;32157095;32357974;32387766;32897882;32938616;32983136;33592498;33912179;33968037;34171305;34932366;35051231;35580925;36215666;36284347;40914422",
        "class_list": "",
        "function": "A Proteomic Connectivity Map for Characterizing the Tumor Adaptive Response to Small Molecule Chemical Perturbagens., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8ND28;Q8WU61;Q9NUR1",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 4.5,
        "record_id": "Q49AR2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NCD3-1",
        "uniprot_id": "HJURP_HUMAN",
        "mass": 83539.0,
        "length": 748,
        "protein_name": "Holliday junction recognition protein",
        "gene_name": "HJURP",
        "organism": "Human",
        "refseq_name": "Holliday junction recognition protein isoform b",
        "refseq_ac": "NP_001269891",
        "gene_names_uniprotkb": "HJURP; FAKTS; FLEG1; URLC9",
        "gene_names_refseq": "FAKTS; HJURP; URLC9; hFLEG1",
        "protein_names_uniprotkb": "Holliday junction recognition protein; 14-3-3-associated AKT substrate; Fetal liver-expressing gene 1 protein; Up-regulated in lung cancer 9",
        "protein_names_refseq": "14-3-3-associated AKT substrate; Holliday junction recognition protein isoform b; fetal liver expressing gene 1; fetal liver-expressing gene 1 protein; up-regulated in lung cancer 9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55355);  (R-HSA-606279);  (R-HSA-69273)",
        "pathway_count": 3,
        "publication_count": 140,
        "publication_id_list": "10.1101/2023.09.13.557529;10393926;10395539;10600115;10652300;10827953;11063929;11237011;11238451;11313932;11897663;11907280;12411508;12754270;1384126;15024056;15302935;15369671;15456846;15572030;16582612;16622419;16622420;16964243;1717476;17199038;17256767;17339379;17533373;17823411;18220336;1828290;18285455;1836978;18384749;18394995;18452278;18669648;18691976;18767875;19160488;19192479;19369195;19398759;19410544;19410545;19413330;19664994;19664995;19690332;20058876;20068231;20080577;20360007;20566683;21406692;21478274;21768289;21813648;21900495;23186163;23242214;23481700;24715725;25418920;25576301;25880248;26154972;26375851;26992070;27499292;27600516;27846572;27920218;28063628;28218747;28228285;28832583;28904123;29154753;29242379;29432282;29437277;29493099;29508533;29557506;29632046;29671580;29769354;30315122;30379171;30524438;30833945;31092671;31530632;31844290;31937595;32157095;32357974;32387766;32502341;32897882;32938616;33141586;33235818;33298915;33392160;33402344;33537174;33592498;33717175;33771996;33912179;33936100;33968037;33981976;34171305;34185709;34211107;34509645;34932366;35051231;35459269;35561310;35580925;35940943;36010968;37848756;37938771;38279062;38561384;7737117;7743995;7799941;8119945;8428596;8440392;9268380;9670027;9679058",
        "class_list": "",
        "function": "Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions., [UniProtKB, PubMed, PubMed]; HFLEG1 is associated with the CENP-A centromeric nucleosome, [RefSeq, PubMed]; HJURP inhibits proliferation of ovarian cancer cells by regulating CENP-A/CENP-N., [RefSeq, PubMed]; HJURP is a key factor for CENP-A deposition and maintenance at centromeres, [RefSeq, PubMed]; HJURP is a possible cell-cycle-regulated CENP-A-specific histone chaperone required for centromeric chromatin assembly, [RefSeq, PubMed]; HJURP is recruited to double-strand break sites and facilitates DNA repair by promoting chromatin reorganization., [RefSeq, PubMed]; HJURP regulates cell proliferation and chemo-resistance via YAP1/NDRG1 transcriptional axis in triple-negative breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of ASF1A and HJURP by global H3-H4 histone chaperone analysis as a prognostic two-gene model in hepatocellular carcinoma. Erratum:[Sci Rep. 2024 Sep 5;14(1):20726. doi: 10.1038/s41598-024-71753-0. PMID: 39251799] Publication Status: Online-Only, [RefSeq, PubMed]; NFE2L1 restrains ferroptosis by transcriptionally regulating HJURP and participates in the progress of oral squamous cell carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 19,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8IRH5;B4DWR0;B4DZV4;Q9BUT2;Q9NSL8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0042393 histone binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000775 chromosome, centromeric region;GO:0000776 kinetochore;GO:0005634 nucleus",
        "go_biological_process": "GO:0007059 chromosome segregation;GO:0043254 regulation of protein-containing complex assembly;GO:0034080 CENP-A containing chromatin assembly;GO:0051101 regulation of DNA binding",
        "synthesized_glycan_count": 0,
        "hit_score": 15.1,
        "record_id": "Q8NCD3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13126-1",
        "uniprot_id": "MTAP_HUMAN",
        "mass": 31236.0,
        "length": 283,
        "protein_name": "S-methyl-5'-thioadenosine phosphorylase",
        "gene_name": "MTAP",
        "organism": "Human",
        "refseq_name": "S-methyl-5'-thioadenosine phosphorylase isoform 1",
        "refseq_ac": "NP_002442",
        "gene_names_uniprotkb": "MTAP; MSAP",
        "gene_names_refseq": "BDMF; DMSFH; DMSMFH; HEL-249; LGMBF; MSAP; MTAP; c86fus",
        "protein_names_uniprotkb": "S-methyl-5'-thioadenosine phosphorylase; 2.4.2.28; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAPase; MTAP",
        "protein_names_refseq": "5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAPase; MeSAdo phosphorylase; S-methyl-5'-thioadenosine phosphorylase isoform 1; S-methyl-5'-thioadenosine phosphorylase; epididymis luminal protein 249; epididymis secretory sperm binding protein",
        "tax_id": 9606,
        "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); diaphyseal medullary stenosis with malignant fibrous histiocytoma (Disease Ontology:DOID:0080664); pancreatic cancer (Disease Ontology:DOID:1793); common bile duct neoplasm (Disease Ontology:DOID:4608)",
        "pathway": " (hsa:4507);  (R-HSA-1237112);  (R-HSA-8950505)",
        "pathway_count": 3,
        "publication_count": 52,
        "publication_id_list": "10404592;11237011;11443076;11895909;14705926;15122881;15302935;15843022;16038020;16408927;17377532;17786183;17912432;19097084;19620624;20068231;20934997;21412930;22464254;23301498;23481700;24715725;26992070;27090790;29437277;29485866;30410026;30860833;3091600;31217245;31844290;32157095;32350084;32357974;33141586;33214551;33717175;34019948;34229054;34357683;34725712;35494241;37277447;38092371;38330461;38665916;38678323;38781764;6785752;7604019;8650244;8687427",
        "class_list": "",
        "function": "Catalyzes the phosphorolytic cleavage of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose1-phosphate (PubMed:3091600, PubMed:8687427, PubMed:10404592). Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis (PubMed:3091600, PubMed:8687427, PubMed:10404592). Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine (PubMed:3091600, PubMed:8687427, PubMed:10404592). Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates (PubMed:10404592)., [UniProtKB, PubMed, HAMAP, PubMed, PubMed]; Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates., [UniProtKB, UniProtKB]; Concordance between CDKN2A homozygous deletion and MTAP immunohistochemical loss in fluoroedenite-induced pleural mesothelioma: An immunohistochemical and molecular study on a single-institution series., [RefSeq, PubMed]; MTAP-ANRIL gene fusion promotes melanoma epithelial-mesenchymal transition-like process by activating the JNK and p38 signaling pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Methylthioadenosine Phosphorylase Genomic Loss in Advanced Gastrointestinal Cancers., [RefSeq, PubMed]; Methylthioadenosine Phosphorylase and Breast Cancer 1 Protein-Associated Protein 1 as Biomarkers for the Peritoneal Mesothelioma., [RefSeq, PubMed]; Purine nucleoside phosphorylase involved in purine salvage., [UniProtKB, HAMAP]; This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage pathway of both adenine and methionine. The encoded enzyme is deficient in many cancers. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2021]., [RefSeq]; [Methylthioadenosine phosphorylase and p16 as surrogate diagnostic markers for CDKN2A homozygous deletion in brain tumors]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "I2G7M5;I2G7M6;I2G7M7;I2G7M8;I2G7M9;I2G7N0;Q5T3P3;Q9H010",
        "ec_number_list": "2.4.2.1;2.4.2.28;3.5.4.4;4.3.3.-",
        "go_molecular_function": "GO:0017061 S-methyl-5-thioadenosine phosphorylase activity;GO:0004645 1,4-alpha-oligoglucan phosphorylase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006139 nucleobase-containing compound metabolic process;GO:0006166 purine ribonucleoside salvage;GO:0019509 L-methionine salvage from methylthioadenosine;GO:0009116 nucleoside metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "Q13126-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6X4T0-1",
        "uniprot_id": "CL054_HUMAN",
        "mass": 14485.0,
        "length": 127,
        "protein_name": "Uncharacterized protein C12orf54",
        "gene_name": "C12orf54",
        "organism": "Human",
        "refseq_name": "uncharacterized protein C12orf54",
        "refseq_ac": "NP_689532",
        "gene_names_uniprotkb": "C12orf54; HSD-29; HSD-30; HSD29; HSD30",
        "gene_names_refseq": "C12orf54; HSD-29; HSD-30",
        "protein_names_uniprotkb": "Uncharacterized protein C12orf54",
        "protein_names_refseq": "uncharacterized protein C12orf54",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:121273)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "11237011;34561969",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6X4S9;Q8N5S2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0045111 intermediate filament cytoskeleton",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q6X4T0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P32321-1",
        "uniprot_id": "DCTD_HUMAN",
        "mass": 20016.0,
        "length": 178,
        "protein_name": "Deoxycytidylate deaminase",
        "gene_name": "DCTD",
        "organism": "Human",
        "refseq_name": "deoxycytidylate deaminase isoform a",
        "refseq_ac": "NP_001012750",
        "gene_names_uniprotkb": "DCTD",
        "gene_names_refseq": "DCTD",
        "protein_names_uniprotkb": "Deoxycytidylate deaminase; 3.5.4.12; dCMP deaminase",
        "protein_names_refseq": "deoxycytidylate deaminase isoform a; deoxycytidylate deaminase",
        "tax_id": 9606,
        "disease": "congenital glutamine deficiency (Disease Ontology:DOID:0070544); developmental and epileptic encephalopathy 116 (Disease Ontology:DOID:0070545); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); heart disease (Disease Ontology:DOID:114); Huntington's disease (Disease Ontology:DOID:12858); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); liver disease (Disease Ontology:DOID:409); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); diabetic retinopathy (Disease Ontology:DOID:8947); amino acid metabolic disorder (Disease Ontology:DOID:9252); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:1635);  (R-HSA-499943)",
        "pathway_count": 2,
        "publication_count": 87,
        "publication_id_list": "10215863;10453732;10618642;10716435;10799505;10884394;10899599;11237011;11277919;11278511;11517226;11796141;11912132;12972261;13211603;14729598;15592455;15630091;16179339;16373698;16756507;16820675;17320107;177353;17824959;18469;1851158;18635542;18997010;19176520;19220460;19766732;21080915;211388;211390;22847445;23186163;23301498;23416111;24714562;2542324;25880248;2656695;2668278;27543614;28228285;28832583;29242379;29508533;29557506;29632711;29786170;30315122;30833945;31154438;31844290;31848261;31998317;32157095;32357974;32387766;32502341;32897882;32938616;32983136;33691108;33717175;33833118;34078123;34171305;34509645;35051231;35580925;36010968;36284347;39534244;40615;5484814;6182143;6248551;7642519;7685356;7851394;8448179;8663313;9488696;9677297",
        "class_list": "",
        "function": "Catalyzes the deamination of dCMP to dUMP, providing the nucleoside monophosphate substrate for the thymidylate synthase/TYMS (PubMed:7685356). Also, part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate) (PubMed:33833118). Catalyzes the first step in that pathway, the deamination of 5-hydroxymethyl-dCMP (hmdCMP) (PubMed:33833118)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 16,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R836;D3DP49;D3DP50;Q5M7Z8;Q9BVD8",
        "ec_number_list": "3.5.4.12",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0070694 5-hydroxymethyl-dUMP N-hydrolase activity;GO:0004132 dCMP deaminase activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006226 dUMP biosynthetic process;GO:0006231 dTMP biosynthetic process;GO:0006220 pyrimidine nucleotide metabolic process;GO:0043174 nucleoside salvage;GO:0009165 nucleotide biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.1,
        "record_id": "P32321-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96FS4-1",
        "uniprot_id": "SIPA1_HUMAN",
        "mass": 112149.0,
        "length": 1042,
        "protein_name": "Signal-induced proliferation-associated protein 1",
        "gene_name": "SIPA1",
        "organism": "Human",
        "refseq_name": "signal-induced proliferation-associated protein 1",
        "refseq_ac": "NP_006738",
        "gene_names_uniprotkb": "SIPA1; SPA1",
        "gene_names_refseq": "SIPA1; SPA1",
        "protein_names_uniprotkb": "Signal-induced proliferation-associated protein 1; GTPase-activating protein Spa-1; Sipa-1; p130 SPA-1",
        "protein_names_refseq": "GTPase-activating protein Spa-1; p130 SPA-1; signal-induced proliferation-associated gene 1; signal-induced proliferation-associated protein 1; sipa-1",
        "tax_id": 9606,
        "disease": "chronic myeloid leukemia (Disease Ontology:DOID:8552)",
        "pathway": " (hsa:6494);  (R-HSA-392517)",
        "pathway_count": 2,
        "publication_count": 93,
        "publication_id_list": "11237011;15632203;17081983;18039662;18220336;18452278;1846040;18669648;18767875;19651622;20058876;20068231;20166139;23186163;23481700;24275569;24366607;24714562;24715725;25418920;25576301;25645385;25880248;25892735;26154972;26375851;26853435;26992070;27846572;27862975;27920218;28218747;28228285;28649982;28832583;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30315122;30410026;30429286;30524438;30833945;31154438;31844290;31848261;31937595;31998317;32157095;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33296812;33298915;33592498;33717175;33753200;33912179;33936100;33968037;33981976;34171305;34211107;34509645;35051231;35580925;36010968;36215666;36241641;36284347;37217939;37500797;8253074;9115221;9346962;9651531;9789079",
        "class_list": "",
        "function": "A novel nuclear localization region in SIPA1 determines protein nuclear distribution and epirubicin-sensitivity of breast cancer cells., [RefSeq, PubMed]; A novel transcription factor SIPA1: identification and verification in triple-negative breast cancer., [RefSeq, PubMed]; GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity)., [UniProtKB, UniProtKB, PubMed]; SIPA1 enhances SMAD2/3 expression to maintain stem cell features in breast cancer cells., [RefSeq, PubMed]; The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 21,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O14518;O60484;O60618;Q2YD83",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005096 GTPase activator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0012505 endomembrane system;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0051056 regulation of small GTPase mediated signal transduction;GO:0007010 cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 9.6,
        "record_id": "Q96FS4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5T2W1-1",
        "uniprot_id": "NHRF3_HUMAN",
        "mass": 57129.0,
        "length": 519,
        "protein_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF3",
        "gene_name": "PDZK1",
        "organism": "Human",
        "refseq_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF3 isoform 1",
        "refseq_ac": "NP_001188254",
        "gene_names_uniprotkb": "PDZK1; CAP70; NHERF3; PDZD1",
        "gene_names_refseq": "CAP70; CLAMP; NHERF-3; NHERF3; PDZD1; PDZK1",
        "protein_names_uniprotkb": "Na(+)/H(+) exchange regulatory cofactor NHE-RF3; CFTR-associated protein of 70 kDa; NHERF-3; Na(+)/H(+) exchanger regulatory factor 3; Na/Pi cotransporter C-terminal-associated protein 1; NaPi-Cap1; PDZ domain-containing protein 1; Sodium-hydrogen exchanger regulatory factor 3",
        "protein_names_refseq": "CFTR-associated protein of 70 kDa; Na(+)/H(+) exchange regulatory cofactor 3; Na(+)/H(+) exchange regulatory cofactor NHE-RF3 isoform 1; Na(+)/H(+) exchange regulatory cofactor NHE-RF3; PDZ-containing kidney protein 1; na/Pi cotransporter C-terminal-associated protein 1; naPi-Cap1; sodium-hydrogen exchanger regulatory factor 3",
        "tax_id": 9606,
        "disease": "hypophosphatemic nephrolithiasis/osteoporosis 2 (Disease Ontology:DOID:0080078)",
        "pathway": " (hsa:5174)",
        "pathway_count": 1,
        "publication_count": 22,
        "publication_id_list": "10496535;11051556;11237011;15215163;15494376;15766278;16141316;19321583;20949066;21653824;24275569;28832583;29242379;29557506;30604288;31154438;33298915;35051231;38669103;38692010;39019845;9461128",
        "class_list": "",
        "function": "A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity)., [UniProtKB]; Findings suggest that PDZ domain containing 1 (PDZK1)_i33968C > T genetic variants may be associated with a higher risk of exhibiting metabolic syndrome GeneRIF: Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator), [RefSeq, PubMed]; Overexpression of PDZK1 is associated with a drug-resistance phenotype in multiple myeloma., [RefSeq, PubMed]; PDZK1 is correlated with DCE-MRI perfusion parameters in high-grade glioma. Publication Status: Online-Only, [RefSeq, PubMed]; PDZK1 protects against mechanical overload-induced chondrocyte senescence and osteoarthritis by targeting mitochondrial function. Publication Status: Online-Only, [RefSeq, PubMed]; Promoter hypomethylated PDZK1 acts as a tumorigenic gene in glioma by interacting with AKT1., [RefSeq, PubMed]; This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 14,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DPB9;E7EU02;O60450;Q5T5P6;Q9BQ41",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005124 scavenger receptor binding;GO:0005102 signaling receptor binding;GO:0044877 protein-containing complex binding;GO:0030165 PDZ domain binding;GO:0043495 protein-membrane adaptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0070062 extracellular exosome;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane",
        "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0090314 positive regulation of protein targeting to membrane;GO:1902603 carnitine transmembrane transport;GO:0044070 regulation of monoatomic anion transport;GO:1905477 positive regulation of protein localization to membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q5T2W1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N865-1",
        "uniprot_id": "SMIP4_HUMAN",
        "mass": 68464.0,
        "length": 590,
        "protein_name": "Sperm-associated microtubule inner protein 4",
        "gene_name": "SPMIP4",
        "organism": "Human",
        "refseq_name": "sperm-associated microtubule inner protein 4",
        "refseq_ac": "NP_620166",
        "gene_names_uniprotkb": "SPMIP4; C7orf31",
        "gene_names_refseq": "C7orf31; SPMIP4",
        "protein_names_uniprotkb": "Sperm-associated microtubule inner protein 4",
        "protein_names_refseq": "sperm associated microtubule inner protein 4; sperm-associated microtubule inner protein 4; uncharacterized protein C7orf31",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:136895)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11237011;25074808;25892735;30064229;30192525;32157095;32588039;32938616;33912179;35051231",
        "class_list": "",
        "function": "LINGO1 might be a positive primary glioblastoma prognostic gene and C7orf31 and VEGFA might be negative prognosticators., [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D165;Q6MZV8;Q6P989;Q7LE28;Q86XK1;Q8N1H5;Q96BN4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005813 centrosome",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q8N865-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9P0L9-1",
        "uniprot_id": "PK2L1_HUMAN",
        "mass": 91982.0,
        "length": 805,
        "protein_name": "Polycystin-2-like protein 1",
        "gene_name": "PKD2L1",
        "organism": "Human",
        "refseq_name": "polycystin-2-like protein 1 isoform 2",
        "refseq_ac": "NP_001240766",
        "gene_names_uniprotkb": "PKD2L1; PKD2L; PKDL; TRPP3",
        "gene_names_refseq": "PCL; PKD2L1; PKD2L; PKDL; TRPP3",
        "protein_names_uniprotkb": "Polycystin-2-like protein 1; Polycystic kidney disease 2-like 1 protein; Polycystin-2 homolog; Polycystin-2L1; Polycystin-L1; Polycystin-L",
        "protein_names_refseq": "polycystic kidney disease 2-like 1 protein; polycystin-2 homolog; polycystin-2-like protein 1 isoform 2; polycystin-2-like protein 1; polycystin-2L1; polycystin-L1; polycystin-L; transient receptor potential cation channel, subfamily P, member 3",
        "tax_id": 9606,
        "disease": "polycystic kidney disease 2 (Disease Ontology:DOID:0110859); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)",
        "pathway": " (hsa:9033)",
        "pathway_count": 1,
        "publication_count": 31,
        "publication_id_list": "10517637;10602361;10602992;11237011;11959145;18452278;19812697;22174419;22193359;23212381;24336289;25645385;25820328;26066678;27754867;29230552;29425510;30004384;31315976;32157095;32350084;33268808;35051231;35494241;35580925;36010968;36655284;36922541;37831088;9748274;9878261",
        "class_list": "",
        "function": "Adaptive selection drives TRPP3 loss-of-function in an Ethiopian population. Publication Status: Online-Only, [RefSeq, PubMed]; Genetic Variants in WNT16 and PKD2L1 Locus Affect Heel Ultrasound Bone Stiffness: Analyses from the General Population and Patients Evaluated for Osteoporosis., [RefSeq, PubMed]; Homotetrameric, non-selective cation channel that is permeable to sodium, potassium, magnesium and calcium (PubMed:10517637, PubMed:11959145, PubMed:25820328, PubMed:27754867, PubMed:29425510, PubMed:30004384). Also forms functional heteromeric channels with PKD1, PKD1L1 and PKD1L3 (PubMed:23212381, PubMed:24336289). Pore-forming subunit of a heterotetrameric, non-selective cation channel, formed by PKD1L2 and PKD1L3, that is permeable to sodium, potassium, magnesium and calcium and which may act as a sour taste receptor in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect (PubMed:19812697, PubMed:23212381). The homomeric and heteromeric channels formed by PKD1L2 and PKD1L3 are activated by low pH and Ca(2+), but opens only when the extracellular pH rises again and after the removal of acid stimulus (PubMed:23212381). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, without affecting cytoplasmic calcium concentration, and regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336289). The PKD1L1:PKD2L1 complex channel is mechanosensitive only at high pressures and is highly temperature sensitive (PubMed:24336289). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1 that produces a transient increase in intracellular calcium concentration upon hypo-osmotic stimulation (200 mOsm) (By similarity). May play a role in the perception of carbonation taste (By similarity). May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Molecular Mechanism of L-Pyroglutamic Acid Interaction with the Human Sour Receptor., [RefSeq, PubMed]; Opening TRPP2 (PKD2L1) requires the transfer of gating charges., [RefSeq, PubMed]; Polycystic kidney disease 2-like 1 channel contributes to the bitter aftertaste perception of quinine. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 32,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75972;Q5W039;Q9UP35;Q9UPA2",
        "ec_number_list": "2.7.11.1;1.8.-.-",
        "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0005262 calcium channel activity;GO:0042802 identical protein binding;GO:0044325 transmembrane transporter binding;GO:0051393 alpha-actinin binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0043235 receptor complex",
        "go_biological_process": "GO:0051289 protein homotetramerization;GO:0055085 transmembrane transport;GO:0098655 monoatomic cation transmembrane transport;GO:0006812 monoatomic cation transport;GO:0035725 sodium ion transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q9P0L9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NCF0-1",
        "uniprot_id": "CL18C_HUMAN",
        "mass": 49585.0,
        "length": 446,
        "protein_name": "C-type lectin domain family 18 member C",
        "gene_name": "CLEC18C",
        "organism": "Human",
        "refseq_name": "C-type lectin domain family 18 member C precursor",
        "refseq_ac": "NP_775890",
        "gene_names_uniprotkb": "CLEC18C; MRLP3",
        "gene_names_refseq": "CLEC18C; MRCL3; MRCL",
        "protein_names_uniprotkb": "C-type lectin domain family 18 member C; Mannose receptor-like protein 3",
        "protein_names_refseq": "C-type lectin domain family 18 member C precursor; mannose receptor-like 3; mannose receptor-like protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283971)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "11237011;26170455;29557506;35051231",
        "class_list": "",
        "function": "Binds polysaccharidesin a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans., [UniProtKB, PubMed]; The human C-type lectin 18 (clec18) gene cluster, which contains three clec18a, clec18b, and clec18c loci, is located in human chromosome 16q22., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IUW8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0030246 carbohydrate binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q8NCF0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TB72-1",
        "uniprot_id": "PUM2_HUMAN",
        "mass": 114216.0,
        "length": 1066,
        "protein_name": "Pumilio homolog 2",
        "gene_name": "PUM2",
        "organism": "Human",
        "refseq_name": "pumilio homolog 2 isoform 2",
        "refseq_ac": "NP_001269681",
        "gene_names_uniprotkb": "PUM2; KIAA0235; PUMH2",
        "gene_names_refseq": "PUM2; PUMH2; PUML2",
        "protein_names_uniprotkb": "Pumilio homolog 2; Pumilio-2",
        "protein_names_refseq": "pumilio homolog 2 isoform 2; pumilio homolog 2; pumilio-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23369);  (R-HSA-8951664)",
        "pathway_count": 2,
        "publication_count": 211,
        "publication_id_list": "10.1101/2023.09.13.557529;10535940;10597293;10811609;10878807;10973499;11069780;11237011;11259415;11292861;11292862;11454738;11585840;11733065;11961546;12101228;12186903;12459267;12504025;12504026;12511597;12526791;12538644;12609982;12682069;12690449;12759363;12771951;12816948;14690597;14757770;15282312;15361859;15367669;15537541;15572695;15574592;15601839;15607425;15652483;15688063;15694336;15799966;16171779;16401342;16547496;16647857;16707496;16790436;16943200;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18093314;18206966;18220336;18669648;18775313;18776931;18805092;18826954;18851830;18926707;19168546;19250909;19321346;19369195;19617556;19690332;19748355;20068231;21397187;21406692;21447816;21463634;21778237;21800163;21863050;21940857;22121020;22306028;22345517;22466964;22537386;22955276;22959436;23125361;23186163;23201271;23333871;23401859;23453757;23481700;23535662;23535663;23563313;23583660;23912815;23986495;24076655;24275569;24366543;24366607;24636985;24715725;24793695;24793696;25314029;25340845;25349211;25355947;25531226;25576301;25645385;25802875;25880248;25892735;26154972;26344709;26375851;26460955;26632597;26724866;26811146;26906416;26992070;27030794;27222660;27397612;27565346;27600516;27846572;27920218;28115426;28228285;28431233;28510447;28514659;28832583;28834231;28904123;29153394;29242379;29393594;29493099;29508533;29557506;29632046;29769354;29786170;30059200;30315122;30379171;30429286;30524438;30610225;31217245;31373491;31492838;31844290;32005965;32157095;32284348;32357974;32387766;32488085;32502341;32753408;32897882;32938616;32983136;33214551;33298915;33392160;33397688;33444648;33537174;33542625;33592498;33717175;33912179;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34357683;34509645;34561969;34932366;35051231;35254053;35289036;35561310;35580925;36010968;36241641;36284347;36536516;37938771;38665916;40914422;9790970;9887101;9891082",
        "class_list": "",
        "function": "CAFs-Derived Exosomal miRNA-130a Confers Cisplatin Resistance of NSCLC Cells Through PUM2-Dependent Packaging. Publication Status: Online-Only, [RefSeq, PubMed]; Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome., [RefSeq, PubMed]; PUM2 and DAZL, are capable of binding the same mRNA sequences in the 3'UTR of human SDAD1 mRNA., [RefSeq, PubMed]; PUM2 as a component of conserved cellular machinery that may be required for germ cell development., [RefSeq, PubMed]; Principles of mRNA control by human PUM proteins elucidated from multimodal experiments and integrative data analysis., [RefSeq, PubMed]; RNA-binding protein PUM2 promotes T-cell acute lymphoblastic leukemia via competitively binding to RBM5 3'UTR with miR-28-5p., [RefSeq, PubMed]; Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KSL0;B4E2B6;D6W527;O00234;Q53TV7;Q8WY43;Q9HAN2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0035198 miRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0106222 lncRNA binding;GO:0062104 pumilio-response element binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0006417 regulation of translation;GO:0060612 adipose tissue development;GO:0060964 regulation of miRNA-mediated gene silencing;GO:0010608 post-transcriptional regulation of gene expression;GO:0043488 regulation of mRNA stability",
        "synthesized_glycan_count": 0,
        "hit_score": 21.9,
        "record_id": "Q8TB72-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q2PZI1-1",
        "uniprot_id": "D19L1_HUMAN",
        "mass": 77319.0,
        "length": 675,
        "protein_name": "Protein C-mannosyl-transferase DPY19L1",
        "gene_name": "DPY19L1",
        "organism": "Human",
        "refseq_name": "protein C-mannosyl-transferase DPY19L1 isoform 2",
        "refseq_ac": "NP_056098",
        "gene_names_uniprotkb": "DPY19L1; GA0500; KIAA0877",
        "gene_names_refseq": "DPY19L1",
        "protein_names_uniprotkb": "Protein C-mannosyl-transferase DPY19L1; 2.4.1.-; Dpy-19-like protein 1; Protein dpy-19 homolog 1",
        "protein_names_refseq": "DPY-19-like protein 1; probable C-mannosyltransferase DPY19L1; protein C-mannosyl-transferase DPY19L1 isoform 2; protein C-mannosyl-transferase DPY19L1; protein dpy-19 homolog 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23333)",
        "pathway_count": 1,
        "publication_count": 40,
        "publication_id_list": "11237011;16526957;23481700;24715725;25418920;25576301;25645385;25880248;25892735;26154972;26992070;27600516;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29437277;29493099;29557506;29769354;30315122;30379171;30410026;30524438;30779550;31844290;32161166;32357974;32387766;32488085;32502341;33141586;33392160;33981976;34185709;34357683;36284347",
        "class_list": "glycogene;glycosyltransferase",
        "function": "C-mannosyltransferase that mediates the C-mannosylation tryptophan residues on target proteins. The reaction occurs on the luminal side of the endoplasmic reticulum and involves the transfer of a mannose unit from a dolichylphosphate mannose (Dol-P-Man) donor to an acceptor protein containing a WxxW consensus sequence (By similarity). C-mannosylates the first two tryptophans in the WxxWxxWxxC motif in thrombospondin (TSP) type-1 of UNC5A (By similarity). Regulates neurite extension during development (By similarity)., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 724,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O94954;Q4G151",
        "ec_number_list": "2.4.1.-",
        "go_molecular_function": "GO:0000030 mannosyltransferase activity;GO:0016757 glycosyltransferase activity",
        "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0018103 protein C-linked glycosylation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "Q2PZI1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6NUT2-1",
        "uniprot_id": "D19L2_HUMAN",
        "mass": 87374.0,
        "length": 758,
        "protein_name": "Probable C-mannosyltransferase DPY19L2",
        "gene_name": "DPY19L2",
        "organism": "Human",
        "refseq_name": "probable C-mannosyltransferase DPY19L2",
        "refseq_ac": "NP_776173",
        "gene_names_uniprotkb": "DPY19L2; PRO10284",
        "gene_names_refseq": "DPY19L2; SPATA34; SPGF9",
        "protein_names_uniprotkb": "Probable C-mannosyltransferase DPY19L2; 2.4.1.-; Dpy-19-like protein 2; Protein dpy-19 homolog 2",
        "protein_names_refseq": "probable C-mannosyltransferase DPY19L2; protein dpy-19 homolog 2; spermatogenesis associated 34",
        "tax_id": 9606,
        "disease": "spermatogenic failure 9 (Disease Ontology:DOID:0111156)",
        "pathway": " (hsa:283417)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "11237011;12975309;16526957;21397063;21397064;22653751;25892735;30192525;30333325;31844290;32157095;32312381;32357974;32488085;32938616;33108537;33377718;33592498;33912179;33968037;34171305;35051231;35580925;35610156;36010968",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Deletion of dpy-19 like 2 (DPY19L2) gene is associated with total but not partial globozoospermia., [RefSeq, PubMed]; Genetic analyses of a large cohort of infertile patients with globozoospermia, DPY19L2 still the main actor, GGN confirmed as a guest player., [RefSeq, PubMed]; Genome-wide compound heterozygote analysis highlights DPY19L2 alleles in a non-consanguineous Spanish family with total globozoospermia., [RefSeq, PubMed]; Here, we performed a screening of DPY19L2 variants in a cohort of Chinese globozoospermic patients and found that five of nine patients carried DPY19L2 deletions and the other four patients contained novel DPY19L2 point mutations, [RefSeq, PubMed]; Patients with globozoospermia have a homozygous deletion of DPY19L2., [RefSeq, PubMed]; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins., [UniProtKB, UniProtKB]; Required during spermatogenesis for sperm head elongation and acrosome formation (PubMed:21397063, PubMed:21397064). Also plays a role in acrosome attachment to the nuclear envelope (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; The protein encoded by this gene belongs to the dpy-19 family. It is highly expressed in testis, and is required for sperm head elongation and acrosome formation during spermatogenesis. Mutations in this gene are associated with an infertility disorder, spermatogenic failure type 9 (SPGF9). [provided by RefSeq, Dec 2011]., [RefSeq]; The relocation of the gene DPY19L2 within a set of low copy repeats. Publication Status: Online-Only, [RefSeq, PubMed]; [Detection of DPY19L2 gene mutation in 2 cases of globozoospermia]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 902,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4FVC1;B4E191;Q3ZCX2;Q6UWG8;Q96LZ9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000030 mannosyltransferase activity;GO:0016757 glycosyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005637 nuclear inner membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007286 spermatid development",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q6NUT2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q16698-1",
        "uniprot_id": "DECR_HUMAN",
        "mass": 36068.0,
        "length": 335,
        "protein_name": "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial",
        "gene_name": "DECR1",
        "organism": "Human",
        "refseq_name": "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform 2",
        "refseq_ac": "NP_001317504",
        "gene_names_uniprotkb": "DECR1; DECR; SDR18C1",
        "gene_names_refseq": "DECR1; DECR; NADPH; SDR18C1",
        "protein_names_uniprotkb": "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial; 1.3.1.124; 2,4-dienoyl-CoA reductase [NADPH]; 4-enoyl-CoA reductase [NADPH]; Short chain dehydrogenase/reductase family 18C member 1",
        "protein_names_refseq": "2,4-dienoyl-CoA reductase 1, mitochondrial; 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform 2; 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial; 2,4-dienoyl-CoA reductase, mitochondrial; 4-enoyl-CoA reductase; short chain dehydrogenase/reductase family 18C member 1",
        "tax_id": 9606,
        "disease": "ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); obesity (Disease Ontology:DOID:9970); progressive encephalopathy with leukodystrophy due to DECR deficiency (MONDO:MONDO:0014464)",
        "pathway": " (hsa:1666);  (R-HSA-77288)",
        "pathway_count": 2,
        "publication_count": 37,
        "publication_id_list": "11237011;14654843;15531764;18491316;19608861;24275569;24847004;26474213;26768311;27452731;28832583;28904123;29242379;29557506;31020640;31217245;31844290;32157095;32350084;32357974;32427840;33592498;33909855;33912179;33968037;34293949;34357683;34896618;35051231;35154160;35251023;36010968;36284347;37497824;38665916;7818482;9403065",
        "class_list": "",
        "function": "Association of whole mtDNA, an NADPH G11914A variant, and haplogroups with high physical performance in an elite military troop. Publication Status: Online-Only, [RefSeq, PubMed]; Auxiliary enzyme in the beta-oxidation of mono- and polyunsaturated fatty acids (Probable) (PubMed:15531764, PubMed:26474213). Together with the Enoyl-CoA delta isomerase 1 (ECI1) and the Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase (ECH1) they allow reentrance of the enoyl-CoA into the beta-oxidation cycle (PubMed:26474213). It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria (PubMed:15531764). Acts primarily on polyunsaturated fatty acids (Probable). Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA (PubMed:15531764). Based on its established catalytic mechanism, it is predicted to act also on other fatty acids besides those tested experimentally (Probable)., [UniProtKB, PubMed, PubMed, PubMed]; DECR1 directly activates HSL to promote lipolysis in cervical cancer cells., [RefSeq, PubMed]; NADPH Oxidases in the Central Nervous System: Regional and Cellular Localization and the Possible Link to Brain Diseases. Review article, [RefSeq, PubMed]; Reduced 2,4-dienoyl-CoA reductase 1 is served as an unfavorable biomarker and is related to immune infiltration in cervical cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z6B8;Q2M304;Q93085",
        "ec_number_list": "1.3.1.124",
        "go_molecular_function": "GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity;GO:0042802 identical protein binding;GO:0070402 NADPH binding;GO:0016491 oxidoreductase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:1902494 catalytic complex",
        "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0120162 positive regulation of cold-induced thermogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q16698-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q66K64-1",
        "uniprot_id": "DCA15_HUMAN",
        "mass": 66463.0,
        "length": 600,
        "protein_name": "DDB1- and CUL4-associated factor 15",
        "gene_name": "DCAF15",
        "organism": "Human",
        "refseq_name": "DDB1- and CUL4-associated factor 15 isoform 1",
        "refseq_ac": "NP_612362",
        "gene_names_uniprotkb": "DCAF15; C19orf72",
        "gene_names_refseq": "C19orf72; DCAF15",
        "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 15",
        "protein_names_refseq": "DDB1- and CUL4-associated factor 15 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:90379)",
        "pathway_count": 1,
        "publication_count": 83,
        "publication_id_list": "11237011;16949367;18669648;19413330;22544926;23186163;23481700;24366607;24714562;24715725;25418920;25645385;26154972;26375851;26728094;26992070;27846572;27862975;27920218;28218747;28228285;28302793;28437394;28489076;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632711;29769354;30315122;30410026;30429286;31154438;31217245;31452512;31530632;31626998;31686031;31693891;31693911;31819272;31844290;31848261;31937595;31998317;32157095;32161166;32200025;32357974;32387766;32488085;32502341;32713946;32897882;32938616;33141586;33298915;33392160;33592498;33691108;33717175;33833131;33912179;33936100;33968037;34087483;34171305;34211107;34357683;34509645;34932366;35051231;35318648;35580925;36010968;36241641;37938771;38961054",
        "class_list": "",
        "function": "Aryl-sulfonamides neo-functionalize a shallow, non-conserved pocket on DCAF15 to selectively bind and degrade RBM39 and the closely related splicing factor RBM23 without the requirement for a high-affinity ligand, [RefSeq, PubMed]; Binding of aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, change the substrate specificity of the DCX(DCAF15) complex, leading to promote ubiquitination and degradation of splicing factor RBM39 (PubMed:28302793, PubMed:28437394, PubMed:31452512, PubMed:31693891). RBM39 degradation results in splicing defects and death in cancer cell lines (PubMed:28302793, PubMed:28437394, PubMed:31693891). Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39 (PubMed:31686031, PubMed:31819272). Aryl sulfonamide anticancer drugs also promote ubiquitination and degradation of RBM23 and PRPF39 (PubMed:31626998, PubMed:31686031, PubMed:31693891)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; DCAF15 control of cohesin dynamics sustains acute myeloid leukemia. Publication Status: Online-Only, [RefSeq, PubMed]; DCAF15 expression may be a useful biomarker to guide clinical trials of splicing inhibitor sulfonamides(SPLAMs). Erratum:[Science. 2017 May 26;356(6340):eaan7977. doi: 10.1126/science.aan7977. PMID: 28546157], [RefSeq, PubMed]; In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins (PubMed:16949367, PubMed:31452512). The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3 (PubMed:31452512). May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells (PubMed:31452512)., [UniProtKB, PubMed, PubMed]; Targeting the E3 ubiquitin ligases DCAF15 and cereblon for cancer therapy. Review article, [RefSeq, PubMed]; Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition by targeting ZEB1 for proteasomal degradation in hepatocellular carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 16,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KS86;Q96DW0;Q9BU31",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0036094 small molecule binding",
        "go_cellular_component": "GO:0080008 Cul4-RING E3 ubiquitin ligase complex",
        "go_biological_process": "GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0002376 immune system process;GO:0032814 regulation of natural killer cell activation",
        "synthesized_glycan_count": 0,
        "hit_score": 8.4,
        "record_id": "Q66K64-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P56749-1",
        "uniprot_id": "CLD12_HUMAN",
        "mass": 27110.0,
        "length": 244,
        "protein_name": "Claudin-12",
        "gene_name": "CLDN12",
        "organism": "Human",
        "refseq_name": "claudin-12",
        "refseq_ac": "NP_001172001",
        "gene_names_uniprotkb": "CLDN12",
        "gene_names_refseq": "CLDN12",
        "protein_names_uniprotkb": "Claudin-12",
        "protein_names_refseq": "claudin-12",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9069);  (R-HSA-420029)",
        "pathway_count": 2,
        "publication_count": 21,
        "publication_id_list": "11230166;11237011;11447115;11964389;12953056;16129888;18669648;19651622;19690332;20166139;20375010;23186163;29557506;30339745;31844290;32350084;33917356;33922921;34932366;35154160;35251023",
        "class_list": "",
        "function": "Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity., [UniProtKB]; Reduced Claudin-12 Expression Predicts Poor Prognosis in Cervical Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, Sep 2011]., [RefSeq]; Tight Junction Protein Claudin-12 Is Involved in Cell Migration during Metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; We found that COPII cargo CLDN12 is important for Hepatitis C Virus entry., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D6W5Q4;Q7LDZ0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016328 lateral plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0035633 maintenance of blood-brain barrier",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "P56749-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6PRD7-1",
        "uniprot_id": "CEMP1_HUMAN",
        "mass": 25959.0,
        "length": 247,
        "protein_name": "Cementoblastoma-derived protein 1",
        "gene_name": "CEMP1",
        "organism": "Human",
        "refseq_name": "cementoblastoma-derived protein 1",
        "refseq_ac": "NP_001041677",
        "gene_names_uniprotkb": "CEMP1",
        "gene_names_refseq": "CEMP1; CP-23; CP23",
        "protein_names_uniprotkb": "Cementoblastoma-derived protein 1; CP-23; Cementum protein 1; Cementum protein 23",
        "protein_names_refseq": "cementoblastoma-derived protein 1; cementum protein 23",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:752014)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "11237011;16263347;17509525;19393626;21465469;21929512;22349547;24117017;26011628;32075221;35442377;37154214",
        "class_list": "",
        "function": "CEMP1 might participate in differentiation and mineralization of nonosteogenic cells, and it might have a potential function in cementum and bone formation, [RefSeq, PubMed]; CEMP1 plays a role during the biomineralization process by promoting octacalcium phosphate crystal nucleation., [RefSeq, PubMed]; Carboxy-Terminal Cementum Protein 1-Derived Peptide 4 (cemp1-p4) Promotes Mineralization through wnt/beta-catenin Signaling in Human Oral Mucosa Stem Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Cementum protein 1 gene-modified adipose-derived mesenchymal stem cell sheets enhance periodontal regeneration in osteoporosis rat., [RefSeq, PubMed]; Human primary cementoblasts subjected to compression and IL-1beta stimulation impeded BSP and CEMP-1 expression, proteins that are associated with cementogenesis., [RefSeq, PubMed]; May play a role in development of the periodontium which surrounds and supports the teeth by promoting the differentiation of multi-potent cells from the periodontal ligament into cementoblasts to form the cementum (PubMed:17509525, PubMed:21465469, PubMed:21929512). Binds hydroxyapatite and may promote the biomineralization of the cementum (PubMed:19393626). Also promotes cell proliferation (PubMed:17509525, PubMed:21929512, PubMed:26011628)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Protease-activated receptor type 1 (PAR1) increases CEMP1 gene expression through MAPK/ERK pathway. Publication Status: Online-Only, [RefSeq, PubMed]; These data demonstrate for the first time that the CEMP1 is not only a marker protein for cementoblast-related cells, but it also regulates cementoblast commitment in periodontal ligament cells, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RUY1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046848 hydroxyapatite binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0008283 cell population proliferation;GO:0030154 cell differentiation;GO:0042476 odontogenesis;GO:0031214 biomineral tissue development",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q6PRD7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6UXB4-1",
        "uniprot_id": "CLC4G_HUMAN",
        "mass": 32562.0,
        "length": 293,
        "protein_name": "C-type lectin domain family 4 member G",
        "gene_name": "CLEC4G",
        "organism": "Human",
        "refseq_name": "C-type lectin domain family 4 member G isoform 1",
        "refseq_ac": "NP_940894",
        "gene_names_uniprotkb": "CLEC4G; PRO792",
        "gene_names_refseq": "CLEC4G; DTTR431; LP2698; LSECtin; UNQ431",
        "protein_names_uniprotkb": "C-type lectin domain family 4 member G; LSECtin; Liver and lymph node sinusoidal endothelial cell C-type lectin",
        "protein_names_refseq": "C-type lectin domain family 4 member G isoform 1; C-type lectin superfamily 4, member G; liver and lymph node sinusoidal endothelial cell C-type lectin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:339390);  (R-HSA-198933)",
        "pathway_count": 2,
        "publication_count": 98,
        "publication_id_list": "10499918;10746781;11237011;11265639;11489943;11513152;11556966;11807247;11857637;11858820;11861603;11955593;11955595;11955599;12213321;12483297;12588680;12975309;14711836;14719373;14970179;15034010;15136729;15155468;15187158;15304001;15489334;15534202;15541655;15580655;15607800;15778510;15781451;15800062;15851719;15864273;16014749;16051304;16091383;16129954;16339513;16380601;16551255;16737824;16754721;16893496;16904340;16928187;17045824;17057721;17237375;17337780;17339424;18031695;18037897;18055229;18083206;18209062;18234675;18593354;18697825;19149696;19359216;19592130;20166139;20730098;21241660;21800138;21841309;21877119;22156524;22396535;22673088;22711492;23695528;23929856;24275569;24305946;24623090;25703557;25716998;26284469;26300885;27862975;29557506;30858559;32199615;32296183;37625828;38731839;7531291;7542404;8178173;8995416;9285412;9314561;9700512;9730896",
        "class_list": "glycogene",
        "function": "(Microbial infection) Acts as a receptor for Ebolavirus., [UniProtKB, PubMed]; (Microbial infection) Acts as a receptor for Japanese encephalitis virus., [UniProtKB, PubMed]; (Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein (PubMed:22156524, PubMed:22673088)., [UniProtKB, PubMed, PubMed]; (Microbial infection) Acts as a receptor for SARS-CoV., [UniProtKB, PubMed]; Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro., [UniProtKB, PubMed]; C-type Lectin Domain Family 4 Member G (CLEC4G) Is a Negative Marker for CD34 in the Evolution of Liver Pathogenesis., [RefSeq, PubMed]; LSECtin is a pathogen-associated molecular pattern receptor in human myeloid cells; results suggest that LSECtin participates in antigen uptake and internalization, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Our results reveal important differences between Ebola virus and HIV-1 capture by DC-SIGN/R and LSECtin and hint towards different biological functions of these lectins., [RefSeq, PubMed]; Reduced Expression of CLEC4G in Neurons Is Associated with Alzheimer's Disease. Publication Status: Online-Only, [RefSeq, PubMed]; Results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor, [RefSeq, PubMed]; This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 412,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0030246 carbohydrate binding;GO:0001618 virus receptor activity;GO:0070061 fructose binding;GO:0005537 D-mannose binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0006955 immune response;GO:0046718 symbiont entry into host cell;GO:1903902 positive regulation of viral life cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 9.9,
        "record_id": "Q6UXB4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P51790-1",
        "uniprot_id": "CLCN3_HUMAN",
        "mass": 90966.0,
        "length": 818,
        "protein_name": "H(+)/Cl(-) exchange transporter 3",
        "gene_name": "CLCN3",
        "organism": "Human",
        "refseq_name": "H(+)/Cl(-) exchange transporter 3 isoform a",
        "refseq_ac": "NP_001230301",
        "gene_names_uniprotkb": "CLCN3",
        "gene_names_refseq": "CLC3; CLCN3; ClC-3; NEDHYBA; NEDSBA",
        "protein_names_uniprotkb": "H(+)/Cl(-) exchange transporter 3; Chloride channel protein 3; Chloride transporter ClC-3; ClC-3",
        "protein_names_refseq": "H(+)/Cl(-) exchange transporter 3 isoform a; chloride channel 3; chloride channel protein 3; chloride channel, voltage-sensitive 3; chloride transporter ClC-3; chloride voltage-gated channel 3; h(+)/Cl(-) exchange transporter 3",
        "tax_id": 9606,
        "disease": "Dent disease (Disease Ontology:DOID:0050699); neuronal ceroid lipofuscinosis 3 (Disease Ontology:DOID:0110731); low molecular weight proteinuria with hypercalciuric nephrocalcinosis (Disease Ontology:DOID:0111815); osteopetrosis (Disease Ontology:DOID:13533); neurodevelopmental disorder with hypotonia and brain abnormalities (MONDO:MONDO:0859187); neurodevelopmental disorder with seizures and brain abnormalities (MONDO:MONDO:0859188)",
        "pathway": " (hsa:1182);  (R-HSA-2672351)",
        "pathway_count": 2,
        "publication_count": 148,
        "publication_id_list": "10198195;10564087;10642508;10720933;10767424;10830164;10831588;11182090;11237011;11274166;11588175;11687798;11734858;11842292;11904445;11956057;11967229;12393854;12471024;12907679;1379744;14584882;14634667;15010458;15044642;15147738;15318163;15504734;15505377;15916532;15919655;16219661;16813530;16849430;16850186;17381423;17448995;17699613;17881003;18000046;18063579;18310267;18400985;18449189;18508966;18662336;18724360;19153159;19307298;19380724;19387438;19620632;19808995;19953639;20388639;20466723;20525693;20538786;21040849;21527911;21984732;22002868;22773952;22946059;2298749;23112050;2321095;23616951;24190977;24715725;2536303;25418920;25502872;25505266;25645385;25892735;26359375;26562072;26811146;26929215;27846572;27862975;27920218;28071645;28154142;28228285;28467828;28790369;28832583;28871256;29242379;29314611;29437277;29493099;29508533;29557506;29632711;29769354;29845874;30315122;30779550;31154438;31844290;31848261;31998317;32157095;32350084;32357974;32387766;32938616;32983136;33069359;33093458;33298915;33383561;33592498;33912179;33936100;33968037;33981976;34186028;34357683;34561969;35051231;35154160;35251023;36010968;36241641;36261097;36284347;7588753;7665160;7795595;8041726;8112288;8383669;8533761;8544406;8626462;8809036;9037075;9395096;9571199;9662395;9678416;9700209;9719863;9744806",
        "class_list": "",
        "function": "ClC-3 silencing mediates lysosomal acidification arrest and autophagy inhibition to sensitize chemo-photothermal therapy., [RefSeq, PubMed]; ClC-3/SGK1 regulatory axis enhances the olaparib-induced antitumor effect in human stomach adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:29845874). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (PubMed:29845874)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Suppression of CLC-3 reduces the proliferation, invasion and migration of colorectal cancer through Wnt/beta-catenin signaling pathway., [RefSeq, PubMed]; Swelling-activated ClC-3 activity regulates prostaglandin E2 release in human OUMS-27 chondrocytes., [RefSeq, PubMed]; This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]., [RefSeq]; Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 6,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z932;B9EGJ9;D3DP34;E9PB97;O14918;Q86Z21",
        "ec_number_list": "",
        "go_molecular_function": "GO:0072320 volume-sensitive chloride channel activity;GO:0005524 ATP binding;GO:0015297 antiporter activity;GO:0030165 PDZ domain binding;GO:0005247 voltage-gated chloride channel activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0045794 negative regulation of cell volume;GO:0048388 endosomal lumen acidification;GO:0006885 regulation of pH;GO:0097401 synaptic vesicle lumen acidification",
        "synthesized_glycan_count": 0,
        "hit_score": 15.1,
        "record_id": "P51790-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P51795-2",
        "uniprot_id": "CLCN5_HUMAN",
        "mass": 90785.0,
        "length": 816,
        "protein_name": "H(+)/Cl(-) exchange transporter 5",
        "gene_name": "CLCN5",
        "organism": "Human",
        "refseq_name": "H(+)/Cl(-) exchange transporter 5 isoform b",
        "refseq_ac": "NP_000075",
        "gene_names_uniprotkb": "CLCN5; CLCK2",
        "gene_names_refseq": "CLC5; CLCK2; CLCN5; ClC-5; DENT1; DENTS; NPHL1; NPHL2; XLRH; XRN; hCIC-K2",
        "protein_names_uniprotkb": "H(+)/Cl(-) exchange transporter 5; Chloride channel protein 5; Chloride transporter ClC-5; ClC-5",
        "protein_names_refseq": "H(+)/Cl(-) exchange transporter 5 isoform b; H(+)/Cl(-) exchange transporter 5; chloride channel, voltage-sensitive 5; chloride transporter ClC-5; chloride voltage-gated channel 5; voltage-gated chloride ion channel CLCN5",
        "tax_id": 9606,
        "disease": "Dent disease (Disease Ontology:DOID:0050699); X-linked recessive hypophosphatemic rickets (Disease Ontology:DOID:0080353); Dent disease 1 (Disease Ontology:DOID:0081453); X-linked nephrolithiasis type I (Disease Ontology:DOID:0111798); low molecular weight proteinuria with hypercalciuric nephrocalcinosis (Disease Ontology:DOID:0111815); prostate cancer (Disease Ontology:DOID:10283); osteopetrosis (Disease Ontology:DOID:13533); renal tubular transport disease (Disease Ontology:DOID:447)",
        "pathway": " (hsa:1184);  (R-HSA-2672351)",
        "pathway_count": 2,
        "publication_count": 130,
        "publication_id_list": "10198195;10564087;10642508;10720933;10767424;10830164;10831588;11136179;11182090;11588175;11687798;11734858;11842292;11904445;11956057;12393854;12886045;12907679;1379744;14584882;14634667;15010458;15044642;15086899;15147738;15318163;15489223;15504734;15505377;15916532;15919655;16219661;16247550;16416111;16813530;16822791;16849430;16850186;17195847;17262170;17381423;17448995;17699613;17881003;18000046;18025833;18063579;18310267;18400985;18449189;18508966;18662336;18724360;19019917;19153159;19307298;19380724;19387438;19620632;19657328;19808995;19953639;20388639;20466723;20525693;20538786;21040849;21305656;21527911;21984732;22002868;22773952;22946059;2298749;23112050;2321095;23616951;24190977;2536303;25645385;26359375;26562072;27600516;28071645;28154142;28790369;29242379;29314611;29605689;32157095;32983136;33298915;33592498;33912179;33968037;34171305;34357683;35051231;35154160;36010968;36215666;37594671;38061527;38665916;38726999;7588753;7665160;7795595;7874126;8041726;8112288;8383669;8533761;8544406;8559248;8575751;8626462;8809036;9037075;9062355;9187673;9259268;9395096;9571199;9602200;9662395;9700209;9719863;9744806;9853249",
        "class_list": "",
        "function": "Clinical features and genetic analysis of 15 Chinese children with dent disease., [RefSeq, PubMed]; Dent disease 1-linked novel CLCN5 mutations result in aberrant location and reduced ion currents., [RefSeq, PubMed]; Dent's disease phenotype may be explained by mutations that affect so far unknown regulating elements of the CLCN5 gene or another gene(s), probably encoding CLC-5 accessory protein(s), [RefSeq, PubMed]; Human parietal epithelial cells (PECs) and proteinuria in lupus nephritis: a role for ClC-5, megalin, and cubilin?, [RefSeq, PubMed]; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (PubMed:20466723). Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable)., [UniProtKB, PubMed]; This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L475;B3KPN6;Q5JQD5;Q7RTN8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0015297 antiporter activity;GO:0005247 voltage-gated chloride channel activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0034220 monoatomic ion transmembrane transport;GO:0006821 chloride transport;GO:0003014 renal system process",
        "synthesized_glycan_count": 0,
        "hit_score": 13.5,
        "record_id": "P51795-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P51801-1",
        "uniprot_id": "CLCKB_HUMAN",
        "mass": 75446.0,
        "length": 687,
        "protein_name": "Chloride channel protein ClC-Kb",
        "gene_name": "CLCNKB",
        "organism": "Human",
        "refseq_name": "chloride channel protein ClC-Kb isoform 1",
        "refseq_ac": "NP_000076",
        "gene_names_uniprotkb": "CLCNKB",
        "gene_names_refseq": "CLCKB; CLCNKB; ClC-K2; ClC-Kb",
        "protein_names_uniprotkb": "Chloride channel protein ClC-Kb; Chloride channel Kb; ClC-K2",
        "protein_names_refseq": "chloride channel protein ClC-Kb isoform 1; chloride channel protein ClC-Kb; chloride channel, kidney, B; chloride channel, voltage-sensitive Kb",
        "tax_id": 9606,
        "disease": "Gitelman syndrome (Disease Ontology:DOID:0050450); megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); Baraitser-Winter syndrome 1 (Disease Ontology:DOID:0081112); Bartter disease type 3 (Disease Ontology:DOID:0110144); Bartter disease type 4b (Disease Ontology:DOID:0110146); autosomal dominant nonsyndromic deafness 20 (Disease Ontology:DOID:0110550); intestinal atresia (Disease Ontology:DOID:10486); hypertension (Disease Ontology:DOID:10763); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); Moyamoya disease (Disease Ontology:DOID:13099); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); alcohol use disorder (Disease Ontology:DOID:1574); myopathy (Disease Ontology:DOID:423); Bartter disease (Disease Ontology:DOID:445)",
        "pathway": " (hsa:1188);  (R-HSA-2672351)",
        "pathway_count": 2,
        "publication_count": 101,
        "publication_id_list": "10564087;10642508;10720933;10767424;10830164;10831588;10906158;11182090;11237011;11588175;11687798;11734858;11842292;11904445;11956057;12111250;12393854;12907679;1379744;14584882;14634667;15010458;15044642;15147738;15318163;15504734;15505377;15916532;15919655;16219661;16813530;16849430;16850186;17381423;17448995;17699613;17881003;18000046;18063579;18310267;18400985;18449189;18508966;18662336;18724360;18776122;19153159;19307298;19380724;19387438;19620632;19646679;19808995;19953639;20388639;20466723;20525693;20538786;21040849;21527911;21984732;22002868;22299025;22773952;22946059;2298749;23112050;2321095;23616951;2536303;26359375;26562072;28071645;28154142;28790369;29557506;31834604;31844290;33807568;35913199;37612755;38069401;39405114;7588753;7665160;7795595;8041726;8112288;8383669;8533761;8544406;8626462;8809036;9037075;9326936;9395096;9571199;9662395;9700209;9719863;9744806",
        "class_list": "",
        "function": "A novel CLCNKB variant in a Chinese family with classic Bartter syndrome and prenatal genetic diagnosis., [RefSeq, PubMed]; Anion-selective channel permeable to small monovalent anions with ion selectivity for chloride > bromide > nitrate > iodide (PubMed:11734858, PubMed:12111250). Forms a homodimeric channel where each subunit has its own ion conduction pathway. May conduct double-barreled currents controlled by two types of gates, two fast gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously (PubMed:11734858, PubMed:12111250, PubMed:16849430, PubMed:18776122, PubMed:19646679). Assembles with the regulatory subunit BSND/Barttin for sorting at the basolateral plasma membrane domain and functional switch to the ion conducting state. CLCNKB:BSND channels display mostly a linear current-voltage relationship controlled by common gate (PubMed:11734858, PubMed:12111250, PubMed:16849430, PubMed:18776122, PubMed:19646679). Mediates chloride conductance along nephron segments, namely the thick ascending limb of Henle's loop, convoluted tubule and the collecting duct, contributing to the maintenance of systemic acid-base and electrolyte homeostasis (By similarity). Conducts chloride currents in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (PubMed:15044642, PubMed:18310267, PubMed:19646679)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Expanding Genotype-Phenotype Correlation of CLCNKA and CLCNKB Variants Linked to Hearing Loss. Publication Status: Online-Only, [RefSeq, PubMed]; Long-read sequencing identifies a common transposition haplotype predisposing for CLCNKB deletions. Publication Status: Online-Only, [RefSeq, PubMed]; Simultaneous Homozygous Mutations in SLC12A3 and CLCNKB in an Inbred Chinese Pedigree. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]., [RefSeq]; Thirteen novel CLCNKB variants and genotype/phenotype association study in 42 Chinese patients with Bartter syndrome type 3., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 16,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KUY3;Q5T5Q7;Q5T5Q8",
        "ec_number_list": "1.8.-.-;1.8.5.1;1.11.1.-;5.6.1.6",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0005247 voltage-gated chloride channel activity;GO:0005254 chloride channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0034707 chloride channel complex",
        "go_biological_process": "GO:0006821 chloride transport;GO:0070293 renal absorption;GO:0030321 transepithelial chloride transport;GO:0070294 renal sodium ion absorption",
        "synthesized_glycan_count": 0,
        "hit_score": 10.2,
        "record_id": "P51801-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P56748-1",
        "uniprot_id": "CLD8_HUMAN",
        "mass": 24845.0,
        "length": 225,
        "protein_name": "Claudin-8",
        "gene_name": "CLDN8",
        "organism": "Human",
        "refseq_name": "claudin-8",
        "refseq_ac": "NP_955360",
        "gene_names_uniprotkb": "CLDN8; PRO1573",
        "gene_names_refseq": "CLDN8; HEL-S-79",
        "protein_names_uniprotkb": "Claudin-8",
        "protein_names_refseq": "claudin-8; epididymis secretory protein Li 79",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9073);  (R-HSA-420029)",
        "pathway_count": 2,
        "publication_count": 11,
        "publication_id_list": "11447115;11964389;12953056;12975309;16129888;17287494;31161266;31526198;31936044;35318648;36008380",
        "class_list": "",
        "function": "Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption. Publication Status: Online-Only, [RefSeq, PubMed]; Can associate with other claudins to regulate tight junction structural and functional strand dynamics (By similarity). May coassemble with CLDN4 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (By similarity) (PubMed:36008380). Cannot form tight junction strands on its own (PubMed:36008380)., [UniProtKB, UniProtKB, PubMed]; MMP1 and CLDN8 were two key genes screened from the differentially expressed genes involved in the pathogenesis of Crohn's disease., [RefSeq, PubMed]; MiR-361-5p inhibits cell proliferation and induces cell apoptosis in retinoblastoma by negatively regulating CLDN8., [RefSeq, PubMed]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DSE3;Q53EX7",
        "ec_number_list": "1.8.-.-;1.8.5.1;1.11.1.-;5.6.1.6",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0160187 paracellular tight junction channel activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016323 basolateral plasma membrane;GO:0016327 apicolateral plasma membrane",
        "go_biological_process": "GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0160184 paracellular transport",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "P56748-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P56750-1",
        "uniprot_id": "CLD17_HUMAN",
        "mass": 24603.0,
        "length": 224,
        "protein_name": "Claudin-17",
        "gene_name": "CLDN17",
        "organism": "Human",
        "refseq_name": "claudin-17",
        "refseq_ac": "NP_036263",
        "gene_names_uniprotkb": "CLDN17; PRO1489",
        "gene_names_refseq": "CLDN17",
        "protein_names_uniprotkb": "Claudin-17",
        "protein_names_refseq": "claudin-17; human CLDN17 gene for claudin-17",
        "tax_id": 9606,
        "disease": "cystitis (Disease Ontology:DOID:1679); post-traumatic stress disorder (Disease Ontology:DOID:2055)",
        "pathway": " (hsa:26285);  (R-HSA-420029)",
        "pathway_count": 2,
        "publication_count": 17,
        "publication_id_list": "11447115;11964389;12517961;12953056;12975309;16129888;20375010;22402829;24325792;26194246;29557506;30219077;30784271;32350084;34781072;35251023;36008380",
        "class_list": "",
        "function": "Channel-forming tight junction protein with selectivity for anions, including chloride and hydrogencarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in paracellular reabsorption of filtered anions. Does not affect water permeability., [UniProtKB, PubMed, PubMed]; Claudin 17 expression was down-regulated in gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; That the upregulated expression of CLDN17 significantly enhances the migration ability of hepatocytes in vitro and we found that the activation of the Stat3 pathway by Tyk2 may an important mechanism by which CLDN17 promotes aggressiveness in hepatocytes Publication Status: Online-Only, [RefSeq, PubMed]; The structural features of Cldn17 contributing to anion channel formation are presented in this work., [RefSeq, PubMed]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11. [provided by RefSeq, Jun 2010]., [RefSeq]; Tight junction protein CLDN17 serves as a tumor suppressor to reduce the invasion and migration of oral cancer cells by inhibiting epithelial-mesenchymal transition., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 15,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3MJB5;Q6UY37",
        "ec_number_list": "1.8.-.-;1.8.5.1;1.11.1.-;5.6.1.6",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0015267 channel activity;GO:0005254 chloride channel activity;GO:0160187 paracellular tight junction channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016323 basolateral plasma membrane;GO:0034707 chloride channel complex;GO:0070160 tight junction",
        "go_biological_process": "GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0160184 paracellular transport",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "P56750-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q03188-1",
        "uniprot_id": "CENPC_HUMAN",
        "mass": 106834.0,
        "length": 943,
        "protein_name": "Centromere protein C",
        "gene_name": "CENPC",
        "organism": "Human",
        "refseq_name": "centromere protein C isoform 1",
        "refseq_ac": "NP_001803",
        "gene_names_uniprotkb": "CENPC; CENPC1; ICEN7",
        "gene_names_refseq": "CENP-C; CENPC1; CENPC; MIF2; hcp-4",
        "protein_names_uniprotkb": "Centromere protein C; CENP-C 1; CENP-C; Centromere autoantigen C; Centromere protein C 1; Interphase centromere complex protein 7",
        "protein_names_refseq": "CENP-C 1; centromere autoantigen C1; centromere protein C 1; centromere protein C isoform 1; interphase centromere complex protein 7",
        "tax_id": 9606,
        "disease": "CREST syndrome (Disease Ontology:DOID:0060218); liver cirrhosis (Disease Ontology:DOID:5082)",
        "pathway": " (hsa:1060);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-5663220);  (R-HSA-606279);  (R-HSA-68877);  (R-HSA-9648025)",
        "pathway_count": 9,
        "publication_count": 144,
        "publication_id_list": "10.1101/2023.09.13.557529;10411507;10600384;10678165;10958683;11081627;11181178;11237011;11371342;11509732;11535616;11804586;11862315;12006501;12194817;12429848;12577064;12679384;12732141;12805219;12852857;1339310;14730319;15006353;15085137;15339662;15369671;15507212;15723797;15737063;15864301;15866170;15944396;16292343;16439214;16541025;16565220;16622419;16622420;16682347;16716197;16890222;16943183;17030981;17081983;17112726;17113138;17129783;17196341;17198702;17199038;17339379;1737036;17651496;18001770;18097444;18669648;18716626;18923426;19007248;19350017;19398759;19410544;19410545;19482874;19503796;19651622;19664995;19690332;19691289;19696148;19815554;19965387;20030946;20068231;20080577;20101212;20566683;20591975;21111234;21148482;21397845;21406692;21529714;21576392;21768289;21868368;21878504;21987589;22094460;22275430;22608513;22790947;22885700;23186163;23222643;23801653;24522885;24715725;24914801;25576301;25740311;25755297;25789526;25892735;26811146;26992070;27499292;28218747;28228285;28446606;28832583;28904123;29242379;29393594;29437277;29557506;29769354;30315122;30379171;30524438;31154438;31409757;31530632;31676716;31844290;31848261;32157095;32387766;32897882;32945564;33065112;33912179;33936100;33968037;34260926;34509645;35051231;36010968;40596516;9645950;9649308;9649503;9892021",
        "class_list": "",
        "function": "A genetic memory initiates the epigenetic loop necessary to preserve centromere position., [RefSeq, PubMed]; CDK1-mediated CENP-C phosphorylation modulates CENP-A binding and mitotic kinetochore localization, [RefSeq, PubMed]; Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]., [RefSeq]; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions., [UniProtKB, PubMed, PubMed]; The Elusive Structure of Centro-Chromatin: Molecular Order or Dynamic Heterogenetity? Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 40,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 41,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6PIR0;Q8IW27;Q9P0M5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0019237 centromeric DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0000776 kinetochore",
        "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051382 kinetochore assembly;GO:0051455 spindle attachment to meiosis I kinetochore;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation",
        "synthesized_glycan_count": 0,
        "hit_score": 15.2,
        "record_id": "Q03188-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q08708-1",
        "uniprot_id": "CLM6_HUMAN",
        "mass": 24830.0,
        "length": 224,
        "protein_name": "CMRF35-like molecule 6",
        "gene_name": "CD300C",
        "organism": "Human",
        "refseq_name": "CMRF35-like molecule 6 precursor",
        "refseq_ac": "NP_006669",
        "gene_names_uniprotkb": "CD300C; CMRF35A1; CMRF35A; CMRF35; IGSF16",
        "gene_names_refseq": "CD300C; CLM-6; CMRF-35A; CMRF-35; CMRF35-A1; CMRF35A1; CMRF35A; CMRF35; IGSF16; LIR",
        "protein_names_uniprotkb": "CMRF35-like molecule 6; CD300 antigen-like family member C; CLM-6; CMRF-35; CMRF35-A1; IgSF16; Immunoglobulin superfamily member 16",
        "protein_names_refseq": "CD300 antigen-like family member C; CD300c antigen; CMRF35 antigen; CMRF35 leukocyte immunoglobulin-like receptor; CMRF35-like molecule 6 precursor; CMRF35-like molecule 6; CMRF35A leukocyte immunoglobulin-like receptor; immunoglobulin superfamily member 16",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10871);  (R-HSA-198933)",
        "pathway_count": 2,
        "publication_count": 93,
        "publication_id_list": "10499918;10746781;11237011;11265639;11489943;11513152;11556966;11807247;11857637;11858820;11861603;11955593;11955595;11955599;12213321;12456026;12483297;12588680;1349532;14719373;14970179;15034010;15136729;15155468;15187158;15304001;15534202;15541655;15580655;15607800;15778510;15781451;15800062;15851719;15864273;16014749;16091383;16129954;16339513;16380601;16551255;16737824;16754721;16893496;16904340;16928187;17045824;17057721;17237375;17337780;18031695;18037897;18055229;18209062;18234675;18535206;18593354;19149696;19359216;19592130;20730098;21241660;21800138;21841309;21877119;22396535;23695528;23929856;24305946;25703557;25716998;26284469;26300885;27040328;28832583;29242379;29393594;29906528;30429286;30498497;31154438;31844290;32387766;32502341;38253038;7531291;7542404;8178173;8995416;9285412;9314561;9700512;9730896",
        "class_list": "",
        "function": "Administration of CD300c-Fc protein attenuates graft-vs.-host disease (GVHD) in mice. Publication Status: Online-Only, [RefSeq, PubMed]; CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from pDCs; CD300a/c RNA and surface expression were downregulated after stimulation of pDCs with TLR7 and TLR9 ligands, [RefSeq, PubMed]; CD300c could be considered a biomarker and therapeutic target in patients with IgE-mediated allergic diseases, [RefSeq, PubMed]; CMRF35A and CMRF35H have roles in immunoglobulin signaling; CMRF35A induces cellular activation and effector function [review] Review article, [RefSeq, PubMed]; Results show that CD300c is exclusively expressed on CD56bright natural killer cells and differentially binds to phosphatidylethanolamine and phosphatidylserine. This expression is under the regulation of STAT5 and Il-4. Publication Status: Online-Only, [RefSeq, PubMed]; The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0006968 cellular defense response;GO:0002376 immune system process;GO:0045088 regulation of innate immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 9.8,
        "record_id": "Q08708-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14CN2-1",
        "uniprot_id": "CLCA4_HUMAN",
        "mass": 101283.0,
        "length": 919,
        "protein_name": "Calcium-activated chloride channel regulator 4",
        "gene_name": "CLCA4",
        "organism": "Human",
        "refseq_name": "calcium-activated chloride channel regulator 4 precursor",
        "refseq_ac": "NP_036260",
        "gene_names_uniprotkb": "CLCA4; CaCC2; PRO1124",
        "gene_names_refseq": "CLCA4; CaCC2; CaCC",
        "protein_names_uniprotkb": "Calcium-activated chloride channel regulator 4; 3.4.-.-; CaCC-2; Calcium-activated chloride channel family member 4; Calcium-activated chloride channel protein 2; Chloride channel accessory 4; hCLCA4; hCaCC-2",
        "protein_names_refseq": "caCC-2; calcium-activated chloride channel family member 4; calcium-activated chloride channel protein 2; calcium-activated chloride channel regulator 4 precursor; calcium-activated chloride channel regulator 4; chloride channel regulator 4; chloride channel, calcium activated, family member 4; hCLCA4; hCaCC-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:22802);  (R-HSA-2672351)",
        "pathway_count": 2,
        "publication_count": 105,
        "publication_id_list": "10437792;10564087;10642508;10720933;10767424;10830164;10831588;11182090;11588175;11687798;11734858;11842292;11904445;11956057;12393854;12907679;12975309;1379744;14584882;14634667;15010458;15044642;15147738;15318163;15490240;15504734;15505377;15916532;15919655;16012037;16219661;16740002;16813530;16849430;16850186;17381423;17448995;17699613;17881003;18000046;18063579;18254958;18310267;18400985;18449189;18491316;18508966;18662336;18724360;19153159;19307298;19380724;19387438;19620632;19808995;19953639;20388639;20466723;20525693;20538786;21040849;21527911;21984732;22002868;22773952;22946059;2298749;23073314;23112050;2321095;23616951;24386311;2536303;26359375;26562072;28071645;28154142;28790369;29242379;29557506;29789417;30887952;31164625;32773719;32797167;34185709;35051231;38825009;7588753;7665160;7795595;8041726;8112288;8383669;8533761;8544406;8626462;8809036;9037075;9395096;9571199;9662395;9700209;9719863;9744806",
        "class_list": "",
        "function": "CLCA1 and CLCA4 may have roles as modulators of the gastrointestinal basic defect in cystic fibrosis, [RefSeq, PubMed]; CLCA4 and CLCA2 play complementary but distinct roles in epithelial differentiation Publication Status: Online-Only, [RefSeq, PubMed]; CLCA4 and MS4A12 as the significant gene biomarkers of primary colorectal cancer., [RefSeq, PubMed]; CLCA4 inhibits migration and invasion by suppressing EMT via PI3K/ATK signaling and predicts favorable prognosis of CRC which may help to distinguish potential risk of lymph node metastasis in CRC. Publication Status: Online-Only, [RefSeq, PubMed]; CLCA4 modulates the capability to express residual chloride secretion in colonic tissue., [RefSeq, PubMed]; Frameshift Mutations and Loss of Expression of CLCA4 Gene are Frequent in Colorectal Cancers With Microsatellite Instability., [RefSeq, PubMed]; May be involved in mediating calcium-activated chloride conductance., [UniProtKB]; Modulation of TMEM16B channel activity by the calcium-activated chloride channel regulator 4 (CLCA4) in human cells., [RefSeq, PubMed]; Six SNPs, c.390C>T (rs190628533), c.1474A>G (rs2231599), c.2105C>G (rs757773924), c.2371A>T) (rs759981524), c.956G>A (rs763334876), and c.895T>C (rs79822589) were identified in the study group of cases in Non-Obstructive Azoospermia but not in control subjects. The allele and genotype frequencies of the six SNPs were not significantly different between the study group and the controls. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008]., [RefSeq]",
        "predicted_glycosites": 14,
        "predicted_n_glycosites": 9,
        "predicted_o_glycosites": 5,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 52,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 15,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MQC9;B7Z1Q5;Q6UX81;Q9UNF7",
        "ec_number_list": "3.4.-.-",
        "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0005254 chloride channel activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0006508 proteolysis;GO:0034220 monoatomic ion transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 10.7,
        "record_id": "Q14CN2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q3C1V1-1",
        "uniprot_id": "CK091_HUMAN",
        "mass": 20547.0,
        "length": 193,
        "protein_name": "Uncharacterized protein C11orf91",
        "gene_name": "C11orf91",
        "organism": "Human",
        "refseq_name": "uncharacterized protein C11orf91",
        "refseq_ac": "NP_001160164",
        "gene_names_uniprotkb": "C11orf91",
        "gene_names_refseq": "C11orf91",
        "protein_names_uniprotkb": "Uncharacterized protein C11orf91",
        "protein_names_refseq": "uncharacterized protein C11orf91",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100131378)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "11237011;24366607;33592498",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3C1V2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q3C1V1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5EE01-1",
        "uniprot_id": "CENPW_HUMAN",
        "mass": 10061.0,
        "length": 88,
        "protein_name": "Centromere protein W",
        "gene_name": "CENPW",
        "organism": "Human",
        "refseq_name": "centromere protein W isoform b",
        "refseq_ac": "NP_001012525",
        "gene_names_uniprotkb": "CENPW; C6orf173; CUG2",
        "gene_names_refseq": "C6orf173; CENP-W; CENPW; CUG2",
        "protein_names_uniprotkb": "Centromere protein W; CENP-W; Cancer-up-regulated gene 2 protein",
        "protein_names_refseq": "cancer-up-regulated gene 2 protein; cancer-upregulated gene 2; centromere protein W isoform b",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:387103);  (R-HSA-606279)",
        "pathway_count": 2,
        "publication_count": 43,
        "publication_id_list": "11237011;15369671;16622420;17079448;17199038;17339379;17610844;19070575;19398759;19410544;19410545;19533040;20075984;20080577;20566683;21695110;21768289;22002061;22304917;24714562;25576301;26728094;26811146;26992070;27600516;27846572;27920218;28832583;28834231;29242379;30315122;30779550;31844290;31848261;32157095;32387766;33592498;33973496;34171305;34416157;35000669;35561310;35580925",
        "class_list": "",
        "function": "Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis., [RefSeq, PubMed]; CUG2 is a new component of the human centromeric complex that is required for proper chromosome segregation during mitosis., [RefSeq, PubMed]; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Data indicate that activation of p38 MAPK and Ras has critical roles in reoviral replication in CUG2-expressing tumor cells., [RefSeq, PubMed]; Knockdown of CENPW Inhibits Hepatocellular Carcinoma Progression by Inactivating E2F Signaling., [RefSeq, PubMed]; Study demonstrates that CENP-W forms a DNA-binding complex together with the CCAN component CENP-T; this complex directly associates with nucleosomal DNA and with canonical histone H3, but not with CENP-A, in centromeric regions., [RefSeq, PubMed]; These findings suggest CUG2 is a novel tumor-associated gene that is commonly activated in various human cancers and exhibits high transforming activities; it possibly belongs to a transcription regulator family that is involved in tumor biogenesis., [RefSeq, PubMed]; Translocalization of enhanced PKM2 protein into the nucleus induced by cancer upregulated gene 2 confers cancer stem cell-like phenotypes., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NIR0;A6NJC2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000775 chromosome, centromeric region;GO:0016363 nuclear matrix",
        "go_biological_process": "GO:0051382 kinetochore assembly;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0034080 CENP-A containing chromatin assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 4.4,
        "record_id": "Q5EE01-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5T681-1",
        "uniprot_id": "CJ062_HUMAN",
        "mass": 25128.0,
        "length": 223,
        "protein_name": "Uncharacterized protein C10orf62",
        "gene_name": "C10orf62",
        "organism": "Human",
        "refseq_name": "uncharacterized protein C10orf62",
        "refseq_ac": "NP_001009997",
        "gene_names_uniprotkb": "C10orf62",
        "gene_names_refseq": "C10orf62; bA548K23.1",
        "protein_names_uniprotkb": "Uncharacterized protein C10orf62",
        "protein_names_refseq": "uncharacterized protein C10orf62",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:414157)",
        "pathway_count": 1,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q49A70;Q8N3Y6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "Q5T681-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5U649-1",
        "uniprot_id": "CL060_HUMAN",
        "mass": 27626.0,
        "length": 245,
        "protein_name": "Uncharacterized protein C12orf60",
        "gene_name": "C12orf60",
        "organism": "Human",
        "refseq_name": "uncharacterized protein C12orf60",
        "refseq_ac": "NP_787070",
        "gene_names_uniprotkb": "C12orf60",
        "gene_names_refseq": "C12orf60",
        "protein_names_uniprotkb": "Uncharacterized protein C12orf60",
        "protein_names_refseq": "uncharacterized protein C12orf60",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:144608)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "26992070;28411811;28904123;29557506;30484775;31217245;31844290;33392160;35051231;35580925;36215666;36241641;37217939",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K1M7;Q5XKK8;Q8IXY2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q5U649-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6EIG7-1",
        "uniprot_id": "CLC6A_HUMAN",
        "mass": 23998.0,
        "length": 209,
        "protein_name": "C-type lectin domain family 6 member A",
        "gene_name": "CLEC6A",
        "organism": "Human",
        "refseq_name": "C-type lectin domain family 6 member A isoform 1",
        "refseq_ac": "NP_001007034",
        "gene_names_uniprotkb": "CLEC6A; CLECSF10; DECTIN2",
        "gene_names_refseq": "CLEC4N; CLEC6A; CLECSF10; dectin-2; hDECTIN-2",
        "protein_names_uniprotkb": "C-type lectin domain family 6 member A; C-type lectin superfamily member 10; DC-associated C-type lectin 2; Dectin-2; Dendritic cell-associated C-type lectin 2",
        "protein_names_refseq": "C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10; C-type lectin domain family 6 member A isoform 1; C-type lectin domain family 6 member A; C-type lectin superfamily member 10; DC-associated C-type lectin 2; dectin 2; dendritic cell-associated C-type lectin 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:93978);  (R-HSA-5621480)",
        "pathway_count": 2,
        "publication_count": 34,
        "publication_id_list": "11110698;11606584;14656219;15175046;15368084;15481152;15489334;15810886;16423983;16541075;17050534;18490740;18776906;18818202;21880719;22041900;23053572;23481700;23507963;23602766;23911656;28652405;29616019;29668708;30443026;31371767;31530632;31868000;33592498;36078084;37813965;8598452;8972730;9042338",
        "class_list": "glycogene",
        "function": "Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas (PubMed:23911656, PubMed:28652405). Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity). Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production (By similarity). Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Deletion of haematopoietic Dectin-2 did not influence atherosclerosis development under hyperglycaemic conditions, despite some minor effects on inflammation., [RefSeq, PubMed]; Dimannoside caps and multivalent interaction are required for ligand binding to and signaling via Dectin-2. Publication Status: Online-Only, [RefSeq, PubMed]; Human DECTIN-2 has a role in innate immunity, [RefSeq, PubMed]; Human thioredoxin, a damage-associated molecular pattern and Malassezia-crossreactive autoallergen, modulates immune responses via the C-type lectin receptors Dectin-1 and Dectin-2. Publication Status: Online-Only, [RefSeq, PubMed]; SOCS3 Regulates Dectin-2-Induced Inflammation in PBMCs of Diabetic Patients. Publication Status: Online-Only, [RefSeq, PubMed]; The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity., [RefSeq, PubMed]; The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 280,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RUK3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005537 D-mannose binding;GO:0043274 phospholipase binding;GO:0038187 pattern recognition receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0001878 response to yeast;GO:0045087 innate immune response;GO:0001819 positive regulation of cytokine production;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q6EIG7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6P2H3-1",
        "uniprot_id": "CEP85_HUMAN",
        "mass": 85639.0,
        "length": 762,
        "protein_name": "Centrosomal protein of 85 kDa",
        "gene_name": "CEP85",
        "organism": "Human",
        "refseq_name": "centrosomal protein of 85 kDa isoform 2",
        "refseq_ac": "NP_001268446",
        "gene_names_uniprotkb": "CEP85; CCDC21",
        "gene_names_refseq": "CCDC21; CEP85",
        "protein_names_uniprotkb": "Centrosomal protein of 85 kDa; Cep85; Coiled-coil domain-containing protein 21",
        "protein_names_refseq": "centrosomal protein 85kDa; centrosomal protein of 85 kDa isoform 2; centrosomal protein of 85 kDa; coiled-coil domain-containing protein 21",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64793)",
        "pathway_count": 1,
        "publication_count": 69,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;17074750;18669648;19664994;20068231;20112406;21399614;23186163;23301498;23481700;24366607;24714562;25418920;25576301;26154972;26220856;26728094;26992070;27846572;27920218;28063628;28218747;28832583;28834231;28904123;29242379;29393594;29437277;29557506;29632046;29712910;29786170;30315122;30484775;30524438;30779550;30833945;31092671;31154438;31530632;31844290;32107292;32157095;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32938750;32983136;33298915;33392160;33592498;33691108;33912179;33968037;33981976;34087483;34185709;34357683;34509645;34932366;35580925;36010968;36241641;37938771",
        "class_list": "",
        "function": "Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856)., [UniProtKB, PubMed, PubMed, PubMed]; Cep85 is a bona fide Nek2A-binding partner that surrounds the proximal ends of centrioles where it cooperates with PP1gamma (also known as PPP1CC) to antagonize Nek2A Erratum:[J Cell Sci. 2015 Oct 15;128(20):3837. doi: 10.1242/jcs.180463. PMID: 26471995], [RefSeq, PubMed]; Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly. Publication Status: Online-Only, [RefSeq, PubMed]; Direct interaction between CEP85 and STIL mediates PLK4-driven directed cell migration. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DRL1;D3DPK4;F8W7K4;Q5VY68;Q5VY70;Q9H6Q1;Q9H828;Q9UF52",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005938 cell cortex",
        "go_biological_process": "GO:0046602 regulation of mitotic centrosome separation;GO:0007059 chromosome segregation;GO:0016477 cell migration;GO:0006469 negative regulation of protein kinase activity;GO:0098534 centriole assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "Q6P2H3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6UXF7-1",
        "uniprot_id": "CL18B_HUMAN",
        "mass": 50490.0,
        "length": 455,
        "protein_name": "C-type lectin domain family 18 member B",
        "gene_name": "CLEC18B",
        "organism": "Human",
        "refseq_name": "C-type lectin domain family 18 member B isoform 2 precursor",
        "refseq_ac": "NP_001011880",
        "gene_names_uniprotkb": "CLEC18B; MRLP1; PRO347",
        "gene_names_refseq": "CLEC18B; MRCL2",
        "protein_names_uniprotkb": "C-type lectin domain family 18 member B; Mannose receptor-like protein 1",
        "protein_names_refseq": "C-type lectin domain family 18 member B isoform 2 precursor; mannose receptor-like 2; mannose receptor-like protein 1; secretory protein LOC497190",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:497190)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "11237011;12975309;26170455;29914265",
        "class_list": "",
        "function": "Binds polysaccharides in a Ca(2+)-independent manner (By similarity)., [UniProtKB, UniProtKB]; The human C-type lectin 18 (clec18) gene cluster, which contains three clec18a, clec18b, and clec18c loci, is located in human chromosome 16q22., [RefSeq, PubMed]; The results from this study showed that CLEC18B was markedly elevated in both GBM tissues and cells, and exhibited strong inverse correlation with overall survival in GBM patients, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DF90",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0030246 carbohydrate binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0016529 sarcoplasmic reticulum;GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q6UXF7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6UXG3-1",
        "uniprot_id": "CLM9_HUMAN",
        "mass": 36060.0,
        "length": 332,
        "protein_name": "CMRF35-like molecule 9",
        "gene_name": "CD300LG",
        "organism": "Human",
        "refseq_name": "CMRF35-like molecule 9 isoform 4 precursor",
        "refseq_ac": "NP_001161794",
        "gene_names_uniprotkb": "CD300LG; CLM9; PRO846; TREM4",
        "gene_names_refseq": "CD300LG; CLM-9; CLM9; NEPMUCIN; TREM-4; TREM4",
        "protein_names_uniprotkb": "CMRF35-like molecule 9; CD300 antigen-like family member G; CLM-9; TREM-4; Triggering receptor expressed on myeloid cells 4",
        "protein_names_refseq": "CD300 antigen-like family member G; CMRF35-like molecule 9 isoform 4 precursor; CMRF35-like molecule 9; triggering receptor expressed on myeloid cells 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:146894);  (R-HSA-198933)",
        "pathway_count": 2,
        "publication_count": 87,
        "publication_id_list": "10499918;10746781;11237011;11265639;11489943;11513152;11556966;11807247;11857637;11858820;11861603;11955593;11955595;11955599;12213321;12483297;12588680;12975309;14719373;14970179;15034010;15136729;15155468;15187158;15304001;15340161;15534202;15541655;15580655;15607800;15778510;15781451;15800062;15851719;15864273;16014749;16091383;16129954;16339513;16380601;16551255;16737824;16754721;16876123;16893496;16904340;16928187;17045824;17057721;17237375;17337780;18031695;18037897;18055229;18209062;18234675;18593354;19149696;19359216;19592130;20730098;21241660;21800138;21841309;21877119;22396535;23695528;23929856;24305946;25314291;25703557;25716998;26284469;26300885;26977771;29485866;29557506;35051231;37217939;7531291;7542404;8178173;8995416;9285412;9314561;9700512;9730896",
        "class_list": "",
        "function": "Blood pressure, measured with a sensitive method, in a small sample of CD300LG rs72836561 CT-carriers was higher than in CC-carriers. Publication Status: Online-Only, [RefSeq, PubMed]; Both mRNA and protein levels of CD300LG-g in pulmonary carcinoma tissues were significantly lower than that in tumor-adjacent tissues, which might lead to inhibition of killing function of immunocytes, resulting in immune escape of lung cancer cells., [RefSeq, PubMed]; Members of the CD300 (see MIM 606786)-like (CD300L) family, such as CD300LG, are widely expressed on hematopoietic cells. All CD300L proteins are type I cell surface glycoproteins that contain a single immunoglobulin (Ig) V-like domain (Takatsu et al., 2006 [PubMed 16876123]).[supplied by OMIM, Mar 2008]., [RefSeq]; Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity)., [UniProtKB]",
        "predicted_glycosites": 25,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 24,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 35,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 25,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DNY5;F5H7P9;F8W9M3;Q8IX38;Q8IX39;Q8TA95",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0032585 multivesicular body membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0002376 immune system process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.0,
        "record_id": "Q6UXG3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z460-1",
        "uniprot_id": "CLAP1_HUMAN",
        "mass": 169451.0,
        "length": 1538,
        "protein_name": "CLIP-associating protein 1",
        "gene_name": "CLASP1",
        "organism": "Human",
        "refseq_name": "CLIP-associating protein 1 isoform 2",
        "refseq_ac": "NP_001135745",
        "gene_names_uniprotkb": "CLASP1; KIAA0622; MAST1",
        "gene_names_refseq": "CLASP1; MAST1",
        "protein_names_uniprotkb": "CLIP-associating protein 1; Cytoplasmic linker-associated protein 1; Multiple asters homolog 1; Protein Orbit homolog 1; hOrbit1",
        "protein_names_refseq": "CLIP-associating protein 1 isoform 2; CLIP-associating protein 1; multiple asters 1; multiple asters homolog 1; protein Orbit homolog 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23332);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-2565942);  (R-HSA-380259);  (R-HSA-380270);  (R-HSA-380284);  (R-HSA-380320);  (R-HSA-428890);  (R-HSA-5620912);  (R-HSA-5663220);  (R-HSA-68877);  (R-HSA-8854518);  (R-HSA-9648025)",
        "pathway_count": 16,
        "publication_count": 271,
        "publication_id_list": "10.1101/2023.09.13.557529;10411507;10600384;10678165;10892742;10958683;11076968;11081627;11181178;11237011;11290329;11371342;11509732;11535616;11804586;11956313;12006501;12194817;12207013;12221128;12364337;12429848;12577064;12679384;12732141;12805219;12837247;12852856;12852857;13678582;14580337;14654843;14730319;15006353;15085137;15302935;15339662;15498487;15507212;15631994;15705883;15723797;15737063;15864301;15866170;15944396;16145243;16292343;16357211;16439214;16462731;16541025;16622419;16622420;16682347;16824950;16866869;16890155;16890222;16914514;16943183;17030981;17081983;17112726;17113138;17129783;17196341;17198702;17322306;1737036;17525332;17543864;17574030;17646400;17719545;18001770;18037885;18077418;18088087;18097444;18212344;18220336;18378770;18477460;18491316;18521620;18566290;18615013;18669648;18694559;18707149;18716626;18767875;18801063;18923426;18991276;19004860;19081074;19350017;19413330;19651622;19664994;19664995;19690332;19691289;19696148;19815554;19940019;19965387;20030946;20068231;20101212;20166139;20230748;20230923;20308558;20399632;20558667;20591975;21111234;21148482;21273506;21347367;21397845;21406692;21422230;21548880;21565611;21576392;21620453;21725307;21792235;21868368;21878504;21987589;22094460;22094468;22179047;22275430;22299025;22365832;22424782;22433857;22544926;22608513;22641346;22653444;22790947;22869377;22885700;23141531;23141541;23186163;23222643;23253480;23301498;23348840;23400999;23481700;23530209;23747070;23769972;23789104;23801653;23921553;24053599;24089205;24231678;24366607;24469809;24715725;24914801;24982133;25047611;25313408;25532896;25576301;25645385;25740311;25789526;26154972;26992070;27543614;27600516;27846572;27920218;28228285;28446606;28514659;28832583;28834231;28855257;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30059200;30315122;30379171;30429286;30779550;30833945;31092671;31154438;31217245;31324691;31409757;31530632;31611695;31844290;31848261;31937595;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33402344;33537174;33587225;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34083810;34087483;34171305;34185709;34211107;34260926;34509645;34561969;34725712;35051231;35251023;35254053;35318648;35513511;35580925;36010968;36215666;36241641;36284347;36581221;37938771;38665916;40596516;40914422;7769006;7790358;8838651;9649308;9649503;9892021",
        "class_list": "",
        "function": "CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]., [RefSeq]; Differential regulation of single microtubules and bundles by a three-protein module., [RefSeq, PubMed]; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 46,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 52,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RU21;B7ZLX3;F5GWS0;O75118;Q2KHQ9;Q5H9P0;Q8N5B8;Q9BQT5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008017 microtubule binding;GO:0002162 dystroglycan binding;GO:0051010 microtubule plus-end binding;GO:0043515 kinetochore binding",
        "go_cellular_component": "GO:0005828 kinetochore microtubule;GO:0045180 basal cortex;GO:0030981 cortical microtubule cytoskeleton;GO:0031592 centrosomal corona;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:1903690 negative regulation of wound healing, spreading of epidermal cells;GO:0031111 negative regulation of microtubule polymerization or depolymerization;GO:0051294 establishment of spindle orientation;GO:0051893 regulation of focal adhesion assembly;GO:0051301 cell division",
        "synthesized_glycan_count": 0,
        "hit_score": 27.9,
        "record_id": "Q7Z460-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z7K6-1",
        "uniprot_id": "CENPV_HUMAN",
        "mass": 29946.0,
        "length": 275,
        "protein_name": "Centromere protein V",
        "gene_name": "CENPV",
        "organism": "Human",
        "refseq_name": "centromere protein V",
        "refseq_ac": "NP_859067",
        "gene_names_uniprotkb": "CENPV; PRR6",
        "gene_names_refseq": "3110013H01Rik; CENP-V; CENPV; PRR6; p30",
        "protein_names_uniprotkb": "Centromere protein V; CENP-V; Nuclear protein p30; Proline-rich protein 6",
        "protein_names_refseq": "centromere protein V; nuclear protein p30; proline rich 6; proline-rich protein 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:201161)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "11237011;12196509;18669648;18772885;20068231;23186163;24275569;26992070;29351928;30429286;31844290;32119511;33214551;33912179;34019948;34171305;35138101;38665916;39531497;40596516",
        "class_list": "",
        "function": "Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis., [UniProtKB, PubMed]; Results suggest that CENP-V (nuclear protein p30) is required for centromere organization, chromosome alignment and cytokinesis in human cells, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RPK2;Q3L8N5;Q8NFH6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008017 microtubule binding;GO:0046872 metal ion binding;GO:0016846 carbon-sulfur lyase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0031965 nuclear membrane;GO:0051233 spindle midzone",
        "go_biological_process": "GO:0033044 regulation of chromosome organization;GO:0031508 pericentric heterochromatin formation;GO:0051301 cell division;GO:0032467 positive regulation of cytokinesis;GO:0001667 ameboidal-type cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q7Z7K6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86T13-1",
        "uniprot_id": "CLC14_HUMAN",
        "mass": 51636.0,
        "length": 490,
        "protein_name": "C-type lectin domain family 14 member A",
        "gene_name": "CLEC14A",
        "organism": "Human",
        "refseq_name": "C-type lectin domain family 14 member A precursor",
        "refseq_ac": "NP_778230",
        "gene_names_uniprotkb": "CLEC14A; C14orf27; EGFR5; PRO269",
        "gene_names_refseq": "C14orf27; CEG1; CLEC14A; EGFR-5",
        "protein_names_uniprotkb": "C-type lectin domain family 14 member A; EGFR-5; Epidermal growth factor receptor 5",
        "protein_names_refseq": "C-type lectin domain family 14 member A precursor; C-type lectin domain family 14 member A; ClECT and EGF-like domain containing protein; epidermal growth factor receptor 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:161198)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "12975309;15340161;15636369;21706054;23644659;24190977;29557506;30429286;30459171;31844290;31852888;31964714;32696621;35051231;35576868;37074911",
        "class_list": "glycogene",
        "function": "An evaluation of the tumour endothelial marker CLEC14A as a therapeutic target in solid tumours., [RefSeq, PubMed]; CLEC14A was up-regulated in hepatocellular carcinoma and may function as a potential diagnostic biomarker. Publication Status: Online-Only, [RefSeq, PubMed]; Clec14a-CTLD may be a key domain in angiogenesis, [RefSeq, PubMed]; In this study, they identify and characterize a novel tumor endothelial marker, CLEC14A, which has properties that suggest it is a candidate for tumor vascular targeting and anti-angiogenic approaches., [RefSeq, PubMed]; Proteomics-based screening of the endothelial heparan sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a heparin-binding protein., [RefSeq, PubMed]; Study identified PAX7-negative human muscle-derived cell colonies also positive for the myogenic markers desmin and MYF5 and reveal the endothelial cell marker CLEC14A to be highly expressed in PAX7null cells. Transplanted PAX7neg cells repopulate the satellite cell niche where they re-express PAX7, or, strikingly, CLEC14A. In conclusion, transplanted human cells do not depend on PAX7 for muscle regeneration. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 804,
        "reported_interactions": 0,
        "missing_score": 3939,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q695G9;Q6PWT6;Q8N5V5",
        "ec_number_list": "",
        "go_molecular_function": "GO:1990430 extracellular matrix protein binding;GO:0030246 carbohydrate binding;GO:0050840 extracellular matrix binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0016477 cell migration;GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway;GO:0002042 cell migration involved in sprouting angiogenesis;GO:0036325 vascular endothelial growth factor receptor-3 signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q86T13-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86VG3-1",
        "uniprot_id": "IFTAP_HUMAN",
        "mass": 25407.0,
        "length": 221,
        "protein_name": "Intraflagellar transport-associated protein",
        "gene_name": "IFTAP",
        "organism": "Human",
        "refseq_name": "intraflagellar transport-associated protein isoform a",
        "refseq_ac": "NP_001263651",
        "gene_names_uniprotkb": "IFTAP; C11orf74; NWC",
        "gene_names_refseq": "C11orf74; HEPIS; IFTAP; NWC",
        "protein_names_uniprotkb": "Intraflagellar transport-associated protein; Protein HEPIS",
        "protein_names_refseq": "intraflagellar transport-associated protein isoform a; uncharacterized protein C11orf74",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:119710)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "11237011;16157265;23186163;23481700;28228285;28832583;30476139;31844290;31848261;32897882;33592498;33968037;34171305;35051231;36010968;37217939",
        "class_list": "",
        "function": "Identification of HEPIS as a protein that binds nsp10 of SARS-CoV, [RefSeq, PubMed]; Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex., [UniProtKB, PubMed]; The C11ORF74, interacts with the IFT-A complex via the IFT122 subunit and is accumulated at the distal tip in the absence of an IFT-A subunit IFT139, suggesting that at least a fraction of C11ORF74 molecules can be transported towards the ciliary tip by associating with the IFT-A complex, although its majority might be out of cilia at steady state., [RefSeq, PubMed]; This gene encodes a protein that was identified as a cellular interacting partner of non-structural protein 10 of the severe acute respiratory syndrome coronavirus (SARS-CoV). The encoded protein may function as a negative regulator of transcription. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DR18;Q96DD6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0120160 intraciliary transport particle A binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0097731 9+0 non-motile cilium",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0007340 acrosome reaction",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q86VG3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IXR9-1",
        "uniprot_id": "CL056_HUMAN",
        "mass": 71046.0,
        "length": 622,
        "protein_name": "Uncharacterized protein C12orf56",
        "gene_name": "C12orf56",
        "organism": "Human",
        "refseq_name": "uncharacterized protein C12orf56 isoform 2",
        "refseq_ac": "NP_001093146",
        "gene_names_uniprotkb": "C12orf56",
        "gene_names_refseq": "C12orf56",
        "protein_names_uniprotkb": "Uncharacterized protein C12orf56",
        "protein_names_refseq": "uncharacterized protein C12orf56 isoform 2; uncharacterized protein C12orf56",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:115749)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "11237011;25892735;29557506;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q8IXR9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IZ96-1",
        "uniprot_id": "CKLF1_HUMAN",
        "mass": 18576.0,
        "length": 169,
        "protein_name": "CKLF-like MARVEL transmembrane domain-containing protein 1",
        "gene_name": "CMTM1",
        "organism": "Human",
        "refseq_name": "CKLF-like MARVEL transmembrane domain-containing protein 1 isoform 13",
        "refseq_ac": "NP_443725",
        "gene_names_uniprotkb": "CMTM1; CKLFSF1",
        "gene_names_refseq": "CKLFH1; CKLFH; CKLFSF1; CMTM1",
        "protein_names_uniprotkb": "CKLF-like MARVEL transmembrane domain-containing protein 1; Chemokine-like factor superfamily member 1",
        "protein_names_refseq": "CKLF-like MARVEL transmembrane domain-containing protein 1 isoform 13; CKLF-like MARVEL transmembrane domain-containing protein 1; chemokine-like factor super family 1; chemokine-like factor superfamily 1; chemokine-like factor superfamily member 1; chemokine-like factor-like protein CKLFH1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:113540)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11237011;12782130;15147728;15778092;19413330;20237496;25175386;25931111;28129775;29393594;29632046;32387766;32983136",
        "class_list": "",
        "function": "Bioinformatics based on CKLF2 cDNA and protein sequences in combination with experimental validation identified CKLFSF1-8 gene clusters, between the SCY and the TM4SF gene families. The 8 family members were cloned and characterized., [RefSeq, PubMed]; CMTM1 and 3 are priority targets in glioblastomas. First insights into signalling of these two genes that might be conveyed by growth factor receptor, Src family kinase and WNT activation was presented., [RefSeq, PubMed]; Gene structure, mapping to chromsome 16, identification of altenative transcription start sites, expression in spermatocyte and testes, [RefSeq, PubMed]; High CMTM1_v17 expression was associated with chemotherapy resistance in lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Novel evidence that the final intron/exon region of the CKLFSF1 gene contains a novel eukaryotic promoter capable of directing expression of the downstream gene, CKLFSF2, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Study shows that CMTM1_v17 is highly expressed in human testis and many human tumor tissues and cell lines and seems to enhance cell proliferation and resistance to tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis in MDA-MB-231 breast cancer cells., [RefSeq, PubMed]; This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CKLF (chemokine-like factor).[provided by RefSeq, Feb 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2PPY5;Q6PEV5;Q8IU76;Q8IU83;Q8IU86;Q8IU93;Q8IZ87;Q8IZ88;Q8IZ89;Q8IZ90;Q8IZ91;Q8IZ92;Q8IZ93;Q8IZ94;Q8IZ95;Q96JC2;Q96JC3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005125 cytokine activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane",
        "go_biological_process": "GO:0006935 chemotaxis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q8IZ96-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N111-1",
        "uniprot_id": "CEND_HUMAN",
        "mass": 14954.0,
        "length": 149,
        "protein_name": "Cell cycle exit and neuronal differentiation protein 1",
        "gene_name": "CEND1",
        "organism": "Human",
        "refseq_name": "cell cycle exit and neuronal differentiation protein 1",
        "refseq_ac": "NP_057648",
        "gene_names_uniprotkb": "CEND1; BM88",
        "gene_names_refseq": "BM88; CEND1",
        "protein_names_uniprotkb": "Cell cycle exit and neuronal differentiation protein 1; BM88 antigen",
        "protein_names_refseq": "BM88 antigen; cell cycle exit and neuronal differentiation protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51286)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11311134;18499894;28657654;29557506;31217245;31844290;32938616;33027701;34549796;35045349",
        "class_list": "",
        "function": "BM88/Cend1 participates in cell cycle control and neuronal differentiation mechanisms during neonatal SVZ neurogenesis and becomes crucial for the transition from neuroblasts to mature neurons when reaching high levels, [RefSeq, PubMed]; CEND1 and miR885 methylation changes associated with successful cognitive aging in community-dwelling older adults., [RefSeq, PubMed]; Cend1 and Neurog2 efficiently reprogram human cortical astrocytes to neural precursor cells and induced-neurons., [RefSeq, PubMed]; Interaction of CEND1 gene and life events in susceptibility to depressive symptoms in Chinese Han college students., [RefSeq, PubMed]; Involved in neuronal differentiation., [UniProtKB, UniProtKB]; The protein encoded by this gene is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9NYM6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "GO:0021686 cerebellar granular layer maturation;GO:0021933 radial glia guided migration of cerebellar granule cell;GO:0021702 cerebellar Purkinje cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q8N111-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N5U0-1",
        "uniprot_id": "CK042_HUMAN",
        "mass": 36368.0,
        "length": 333,
        "protein_name": "Uncharacterized protein C11orf42",
        "gene_name": "C11orf42",
        "organism": "Human",
        "refseq_name": "uncharacterized protein C11orf42",
        "refseq_ac": "NP_775796",
        "gene_names_uniprotkb": "C11orf42",
        "gene_names_refseq": "C11orf42",
        "protein_names_uniprotkb": "Uncharacterized protein C11orf42",
        "protein_names_refseq": "uncharacterized protein C11orf42",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:160298)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "31429579;35051231;36010968",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0036126 sperm flagellum",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q8N5U0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N6F1-1",
        "uniprot_id": "CLD19_HUMAN",
        "mass": 23229.0,
        "length": 224,
        "protein_name": "Claudin-19",
        "gene_name": "CLDN19",
        "organism": "Human",
        "refseq_name": "claudin-19 isoform b",
        "refseq_ac": "NP_001116867",
        "gene_names_uniprotkb": "CLDN19",
        "gene_names_refseq": "CLDN19; HOMG5",
        "protein_names_uniprotkb": "Claudin-19",
        "protein_names_refseq": "claudin-19 isoform b",
        "tax_id": 9606,
        "disease": "renal hypomagnesemia 5 with ocular involvement (Disease Ontology:DOID:0060881)",
        "pathway": " (hsa:149461);  (R-HSA-420029)",
        "pathway_count": 2,
        "publication_count": 15,
        "publication_id_list": "11447115;11964389;12953056;16129888;17033971;18188451;19706394;25555744;28028216;30937396;32161166;33591357;33929692;36008380;36241641",
        "class_list": "",
        "function": "Forms paracellular channels: coassembles with CLDN16 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:18188451, PubMed:28028216). Involved in the maintenance of ion gradients along the nephron. In the thick ascending limb (TAL) of Henle's loop, facilitates sodium paracellular permeability from the interstitial compartment to the lumen, contributing to the lumen-positive transepithelial potential that drives paracellular magnesium and calcium reabsorption (By similarity) (PubMed:17033971, PubMed:25555744). Forms paracellular barriers on its own. In the peripheral nervous system, represents a major constituent of the tight junctions in Schwann cells and contributes to electrical sealing. During retinal neurogenesis, may regulate the barrier properties of tight junctions in retinal pigment epithelium, required for proper retinal tissue differentiation and vision (By similarity) (PubMed:17033971, PubMed:30937396)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Heterogeneity is a common ground in familial hypomagnesemia with hypercalciuria and nephrocalcinosis caused by CLDN19 gene mutations., [RefSeq, PubMed]; Knockdown of Claudin-19 in the Retinal Pigment Epithelium Is Accompanied by Slowed Phagocytosis and Increased Expression of SQSTM1., [RefSeq, PubMed]; Mutated claudin-19 affects multiple stages of RPE and retinal differentiation through its effects on multiple functions of the RPE. Publication Status: Online-Only, [RefSeq, PubMed]; The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z5I2;F5H5P9;Q5QT57;Q8N8X0",
        "ec_number_list": "2.7.11.1;1.8.-.-",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0098632 cell-cell adhesion mediator activity;GO:0160187 paracellular tight junction channel activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016323 basolateral plasma membrane;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0043297 apical junction assembly;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0034329 cell junction assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q8N6F1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N6G5-1",
        "uniprot_id": "CGAT2_HUMAN",
        "mass": 62572.0,
        "length": 542,
        "protein_name": "Chondroitin sulfate N-acetylgalactosaminyltransferase 2",
        "gene_name": "CSGALNACT2",
        "organism": "Human",
        "refseq_name": "chondroitin sulfate N-acetylgalactosaminyltransferase 2 isoform 2",
        "refseq_ac": "NP_001306583",
        "gene_names_uniprotkb": "CSGALNACT2; CHGN2; GALNACT2; PRO0082",
        "gene_names_refseq": "CHGN2; CSGALNACT2; ChGn-2; GALNACT-2; GALNACT2; PRO0082; beta4GalNAcT",
        "protein_names_uniprotkb": "Chondroitin sulfate N-acetylgalactosaminyltransferase 2; 2.4.1.174; Beta4GalNAcT-2; Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2; GalNAcT-2",
        "protein_names_refseq": "beta 4 GalNAcT-2; chondroitin beta1,4 N-acetylgalactosaminyltransferase 2; chondroitin sulfate N-acetylgalactosaminyltransferase 2 isoform 2; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55454);  (R-HSA-2022870)",
        "pathway_count": 2,
        "publication_count": 50,
        "publication_id_list": "10.1101/2023.09.13.557529;10187838;10781596;10781601;10963998;11056388;11139592;11483580;11514575;11788602;12080076;12145278;12163485;12433924;12446672;12761225;12874280;12907687;17227754;18316376;21129727;21129728;25892735;26992070;27599773;27846572;28218747;28467828;28834231;28904123;29242379;29437277;29514872;29632046;30579596;31530632;31844290;32265295;32350084;32897882;32938616;33912179;33968037;33981976;34357683;35051231;35251023;35580925;38082211;9883891",
        "class_list": "glycogene;glycosyltransferase",
        "function": "CSGALNACT2 restricts ovarian cancer migration and invasion by modulating MAPK/ERK pathway through DUSP1., [RefSeq, PubMed]; Chondroitin sulfate N-acetylgalactosaminyltransferase 2 is functionally involved in the progression of atherosclerosis both in its early and advanced stages., [RefSeq, PubMed]; Plays a role in the initiation and elongation in the synthesis of chondroitin sulfate, [RefSeq, PubMed]; This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. The encoded protein is involved in elongation during chondroitin sulfate synthesis. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome X. [provided by RefSeq, Feb 2016]., [RefSeq]; Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 597,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KWL7;Q6MZJ5;Q6MZP6;Q8TCH4;Q9P1I6",
        "ec_number_list": "2.4.1.174;2.4.1.-",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0008376 acetylgalactosaminyltransferase activity;GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane;GO:0032580 Golgi cisterna membrane",
        "go_biological_process": "GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0050651 dermatan sulfate proteoglycan biosynthetic process;GO:0030166 proteoglycan biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "Q8N6G5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N884-1",
        "uniprot_id": "CGAS_HUMAN",
        "mass": 58814.0,
        "length": 522,
        "protein_name": "Cyclic GMP-AMP synthase",
        "gene_name": "CGAS",
        "organism": "Human",
        "refseq_name": "cyclic GMP-AMP synthase isoform 1",
        "refseq_ac": "NP_612450",
        "gene_names_uniprotkb": "CGAS; C6orf150; MB21D1",
        "gene_names_refseq": "C6orf150; CGAS; D4; MB21D1; h-cGAS",
        "protein_names_uniprotkb": "Cyclic GMP-AMP synthase; 2'3'-cGAMP synthase; 2.7.7.86; Mab-21 domain-containing protein 1; cGAMP synthase; cGAS; h-cGAS",
        "protein_names_refseq": "2'3'-cGAMP synthase; DANGER family member 4; Mab-21 domain containing 1; cGAMP synthase; cyclic GMP-AMP synthase isoform 1; mab-21 domain-containing protein 1; protein MB21D1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:115004);  (R-HSA-1834941);  (R-HSA-9920588)",
        "pathway_count": 3,
        "publication_count": 186,
        "publication_id_list": "11237011;15592455;16920715;18496526;18559423;19433799;19608861;19754307;20068231;20890285;21098106;21170271;21478870;21566123;21575908;21813776;21892174;21947006;22394562;22579474;22691496;22705373;22728658;23142775;23222971;23258412;23258413;23481700;23707061;23707065;23722159;23929945;24077100;24116191;24173023;24269171;24332030;24397554;24462292;24714562;24715725;25131990;25418920;26046437;26048138;26154972;26229115;26300263;26320998;26375851;26440888;26728094;26929215;26992070;27637147;27666593;27832191;27862975;27920218;28214358;28218747;28228285;28273161;28314590;28363908;28649982;28738408;28759889;28764923;28832583;28834231;28904123;28934246;28940468;29242379;29393594;29426904;29437277;29493099;29508533;29557506;29632046;29760876;29937271;29976794;30007416;30092200;30135424;30270045;30315122;30356214;30410026;30429286;30524438;30550790;30799039;30811988;30827685;30833945;30878284;31107917;31113940;31142647;31154438;31299200;31530632;31534008;31544964;31808743;31844290;31848261;31867016;31992625;32152943;32157095;32161166;32265295;32350084;32351706;32357974;32387766;32404352;32432721;32459092;32474700;32488085;32502341;32715615;32778820;32792394;32814054;32817552;32852081;32897882;32911480;32911481;32911482;32912999;32938616;32983136;33031745;33051594;33057424;33141586;33230297;33273464;33298915;33392160;33406424;33476576;33542149;33606975;33633747;33688080;33717175;33912179;33936100;33968037;34015248;34111399;34171305;34387695;34509645;34543359;34561969;34932366;35045565;35051231;35210392;35322803;35438208;35460603;35503863;35580925;35613581;36010968;36284347;37217469;37802025;38418882;39120648;39183465;39322678;39378929;39431915;41073405",
        "class_list": "",
        "function": "Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100, PubMed:31992625). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Poxin-deficient poxviruses are sensed by cGAS prior to genome replication., [RefSeq, PubMed]; R-loops and impaired autophagy trigger cGAS-dependent inflammation via micronuclei formation in Senataxin-deficient cells. Publication Status: Online-Only, [RefSeq, PubMed]; The crucial roles and research advances of cGAS-STING pathway in liver diseases. Review article, [RefSeq, PubMed]; These results indicate that cGAS is a cytosolic DNA sensor that induces interferons by producing the second messenger cGAMP., [RefSeq, PubMed]; Unravelling the interplay between ER stress, UPR and the cGAS-STING pathway: Implications for osteoarthritis pathogenesis and treatment strategy. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 17,
        "reported_mutagensis": 134,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "L0L2J9;Q14CV6;Q32NC9;Q5SWL0;Q5SWL1;Q96E45",
        "ec_number_list": "2.7.7.86",
        "go_molecular_function": "GO:0061501 2',3'-cyclic GMP-AMP synthase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0005525 GTP binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0002221 pattern recognition receptor signaling pathway;GO:0006281 DNA repair;GO:0045087 innate immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 18.7,
        "record_id": "Q8N884-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N999-1",
        "uniprot_id": "RLIG1_HUMAN",
        "mass": 37490.0,
        "length": 325,
        "protein_name": "RNA ligase 1",
        "gene_name": "RLIG1",
        "organism": "Human",
        "refseq_name": "RNA ligase 1",
        "refseq_ac": "NP_001009894",
        "gene_names_uniprotkb": "RLIG1; C12orf29",
        "gene_names_refseq": "C12orf29; RLIG1; Rnl",
        "protein_names_uniprotkb": "RNA ligase 1; 6.5.1.3; RNA ligase; Rnl",
        "protein_names_refseq": "RNA ligase 1; RNA ligase; uncharacterized protein C12orf29",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91298)",
        "pathway_count": 1,
        "publication_count": 29,
        "publication_id_list": "11237011;22645359;24714562;24715725;25576301;25880248;26992070;28510447;28832583;29242379;29437277;29557506;30410026;31217245;31844290;32157095;32357974;32387766;32502341;32897882;32938616;33691108;33717175;33912179;33968037;34171305;34509645;36010968;36792600",
        "class_list": "",
        "function": "Functions as an RNA ligase, in vitro (PubMed:36792600). The ligation reaction entails three nucleotidyl transfer steps (PubMed:36792600). In the first step, the RNA ligase reacts with ATP in the absence of nucleic acid to form a covalent ligase-AMP intermediate and release pyrophosphate (PubMed:36792600). In step 2, the ligase-AMP binds to the nucleic acid and transfers the adenylate to the 5'-PO4 terminus to form an adenylylated intermediate (PubMed:36792600). In step 3, the RNA ligase directs the attack of the 3'-OH on the 5'-phosphoanhydride linkage, resulting in a repaired 3'-5' phosphodiester and release of AMP (PubMed:36792600). Exhibits selectivity for single-stranded RNA substrates and may not have nick-sealing activity on double-stranded DNA-RNA hybrids (PubMed:36792600). May play a role in maintaining RNA integrity under stress conditions, for example in response to reactive oxygen species (ROS) (PubMed:36792600)., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q569K5;Q6AWA8;Q6PEK5;Q8IYQ5;Q9NT75",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0003972 RNA ligase (ATP) activity",
        "go_cellular_component": "",
        "go_biological_process": "GO:0000302 response to reactive oxygen species;GO:0042245 RNA repair",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q8N999-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TAZ6-1",
        "uniprot_id": "CKLF2_HUMAN",
        "mass": 27496.0,
        "length": 248,
        "protein_name": "CKLF-like MARVEL transmembrane domain-containing protein 2",
        "gene_name": "CMTM2",
        "organism": "Human",
        "refseq_name": "CKLF-like MARVEL transmembrane domain-containing protein 2 isoform 2",
        "refseq_ac": "NP_001186246",
        "gene_names_uniprotkb": "CMTM2; CKLFSF2",
        "gene_names_refseq": "CKLFSF2; CMTM2",
        "protein_names_uniprotkb": "CKLF-like MARVEL transmembrane domain-containing protein 2; Chemokine-like factor superfamily member 2",
        "protein_names_refseq": "CKLF-like MARVEL transmembrane domain-containing protein 2 isoform 2; CKLF-like MARVEL transmembrane domain-containing protein 2; chemokine-like factor superfamily 2; chemokine-like factor superfamily member 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:146225)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;12782130;15778092;15896670;17334588;21034562;22901147;28816268;31990600;32938616;33101541",
        "class_list": "",
        "function": "Aberrant DNA methylation of CMTM2 gene is associated with colorectal cancer., [RefSeq, PubMed]; Bioinformatics based on CKLF2 cDNA and protein sequences in combination with experimental validation identified CKLFSF1-8 gene clusters, between the SCY and the TM4SF gene families. The 8 family members were cloned and characterized., [RefSeq, PubMed]; CKLFSF2 was specifically expressed in meiotic and post-meiotic germ cells, which were localized to the endoplasmic reticulum (ER) near the Golgi apparatus., [RefSeq, PubMed]; CMTM2 is downregulated in hepatocellular carcinoma tissues and correlated with the prognosis of hepatocellular carcinoma patients, suggesting a potential tumor suppressor role of CMTM2 in hepatocellular carcinoma progression., [RefSeq, PubMed]; He expression of CMTM2 in the male reproductive system of the adult human exhibits cell- and region-specific patterns, which suggests that they may play an important role in spermatogenesis and sperm-egg fusion, [RefSeq, PubMed]; Identification of Serum CMTM2 as a Potential Biomarker for HBV-Related Disorders. Publication Status: Online-Only, [RefSeq, PubMed]; Intracellular CMTM2 can negatively regulate HIV-1 transcription, at least in part, by targeting the AP-1 and CREB pathways., [RefSeq, PubMed]; Novel evidence that the final intron/exon region of the CKLFSF1 gene contains a novel eukaryotic promoter capable of directing expression of the downstream gene, CKLFSF2, [RefSeq, PubMed]; This gene belongs to the chemokine-like factor gene superfamily, a novel family that links the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5I2A4;Q8N7E5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005125 cytokine activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane",
        "go_biological_process": "GO:0006935 chemotaxis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q8TAZ6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WW14-1",
        "uniprot_id": "SMIP5_HUMAN",
        "mass": 26343.0,
        "length": 234,
        "protein_name": "Sperm-associated microtubule inner protein 5",
        "gene_name": "SPMIP5",
        "organism": "Human",
        "refseq_name": "sperm-associated microtubule inner protein 5 isoform 1",
        "refseq_ac": "NP_653262",
        "gene_names_uniprotkb": "SPMIP5; C10orf82",
        "gene_names_refseq": "C10orf82; SPMIP5",
        "protein_names_uniprotkb": "Sperm-associated microtubule inner protein 5",
        "protein_names_refseq": "sperm associated microtubule inner protein 5; sperm-associated microtubule inner protein 5 isoform 1; uncharacterized protein C10orf82",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:143379)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "25609838",
        "class_list": "",
        "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KUM9;D3DRC3;K7EKP3",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "Q8WW14-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WWK9-1",
        "uniprot_id": "CKAP2_HUMAN",
        "mass": 76987.0,
        "length": 683,
        "protein_name": "Cytoskeleton-associated protein 2",
        "gene_name": "CKAP2",
        "organism": "Human",
        "refseq_name": "cytoskeleton-associated protein 2 isoform 2",
        "refseq_ac": "NP_001091995",
        "gene_names_uniprotkb": "CKAP2; LB1; TMAP",
        "gene_names_refseq": "CKAP2; LB1; TMAP; se20-10",
        "protein_names_uniprotkb": "Cytoskeleton-associated protein 2; CTCL tumor antigen se20-10; Tumor- and microtubule-associated protein",
        "protein_names_refseq": "CTCL tumor antigen se20-10; cytoskeleton-associated protein 2 isoform 2; tumor- and microtubule-associated protein; tumor-associated microtubule-associated protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26586)",
        "pathway_count": 1,
        "publication_count": 81,
        "publication_id_list": "10.1101/2023.09.13.557529;11149944;11230166;11234418;11237011;12500535;12942315;17376772;17924679;18669648;19007248;19369249;19690332;19691289;20068231;20458174;23186163;23301498;23481700;24714562;24715725;25418920;25576301;25810538;26929215;26992070;27600516;27920218;28411811;28514659;28832583;28834231;28904123;29242379;29393594;29508533;29557506;29632046;29789417;30315122;30379171;30410026;30429286;30484775;30620550;31217245;31844290;31848261;31998317;32119511;32157095;32161166;32387766;32502341;32897882;32938616;32983136;33298915;33537174;33592498;33691108;33912179;33936100;33968037;33981976;34171305;34216644;34596006;34932366;35051231;35561310;35580925;35853854;35905213;36010968;36241641;37217939;37938771;40596516;40914422;9771967",
        "class_list": "",
        "function": "CKAP2 comprises nine exons ranging 70-1442 bp and is about 22 kb in size (regulatory regions included). The CKAP2 promoter contains CCAAT (-39...-33) rather than the canonical TATA box, and harbors nine binding sites for six transcription factors, [RefSeq, PubMed]; CKAP2 overexpression correlates with worse overall survival in patients with lung adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Cytoskeleton-associated protein 2 (CKAP2) is regulated by vascular endothelial growth factor and p53 in retinal capillary endothelial cells under high-glucose conditions., [RefSeq, PubMed]; LncRNA DARS-AS1 aggravates the growth and metastasis of hepatocellular carcinoma via regulating the miR-3200-5p-Cytoskeleton associated protein 2 (CKAP2) axis., [RefSeq, PubMed]; Long non-coding RNA DLEU1 promotes malignancy of breast cancer by acting as an indispensable coactivator for HIF-1alpha-induced transcription of CKAP2. Publication Status: Online-Only, [RefSeq, PubMed]; Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity)., [UniProtKB]; This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 30,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2BDE0;A5YM58;B4DR35;E9PD90;Q3KRA5;Q5VXB4;Q8IWV5;Q8IWV6;Q96FH9;Q9H012;Q9H0D0;Q9H988;Q9HC49;Q9NVG4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton",
        "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0000281 mitotic cytokinesis;GO:0007026 negative regulation of microtubule depolymerization",
        "synthesized_glycan_count": 0,
        "hit_score": 8.8,
        "record_id": "Q8WWK9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96LM1-1",
        "uniprot_id": "CL037_HUMAN",
        "mass": 14531.0,
        "length": 132,
        "protein_name": "Putative uncharacterized protein encoded by LINC00615",
        "gene_name": "LINC00615",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "LINC00615; C12orf37",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative uncharacterized protein encoded by LINC00615",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 3,
        "publication_id_list": "30379171;35051231;35154160",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q96LM1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96LP6-1",
        "uniprot_id": "CL042_HUMAN",
        "mass": 39738.0,
        "length": 360,
        "protein_name": "Uncharacterized protein C12orf42",
        "gene_name": "C12orf42",
        "organism": "Human",
        "refseq_name": "uncharacterized protein C12orf42 isoform 1",
        "refseq_ac": "NP_001092806",
        "gene_names_uniprotkb": "C12orf42",
        "gene_names_refseq": "C12orf42",
        "protein_names_uniprotkb": "Uncharacterized protein C12orf42",
        "protein_names_refseq": "uncharacterized protein C12orf42 isoform 1; uncharacterized protein C12orf42",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:374470)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11237011;20659153;29242379;29557506;31844290;32983136;34561969",
        "class_list": "",
        "function": "Deletional rearrangement of the TCR delta gene disrupted the hypothetical gene C12orf42 and brought the Achaete-scute complex homolog 1 gene into proximity of the TRA enhancer, which is overexpressed in thyroid and lung cancers, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q49A64;Q4G0S2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q96LP6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96S66-1",
        "uniprot_id": "CLCC1_HUMAN",
        "mass": 62023.0,
        "length": 551,
        "protein_name": "Chloride channel CLIC-like protein 1",
        "gene_name": "CLCC1",
        "organism": "Human",
        "refseq_name": "chloride channel CLIC-like protein 1 isoform 1 precursor",
        "refseq_ac": "NP_001041675",
        "gene_names_uniprotkb": "CLCC1; KIAA0761; MCLC",
        "gene_names_refseq": "CLCC1; ERAC1; MCLC; RP32",
        "protein_names_uniprotkb": "Chloride channel CLIC-like protein 1; ER anion channel 1; ERAC1; Mid-1-related chloride channel protein",
        "protein_names_refseq": "ER anion channel 1; Mid-1-related chloride channel protein 1; chloride channel CLIC-like protein 1 isoform 1 precursor; chloride channel CLIC-like protein 1; retinitis pigmentosa 32 (autosomal recessive)",
        "tax_id": 9606,
        "disease": "retinitis pigmentosa 32 (Disease Ontology:DOID:0110355)",
        "pathway": " (hsa:23155)",
        "pathway_count": 1,
        "publication_count": 74,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;11237011;11279057;16189710;17081983;17924679;18669648;18691976;19413330;19651622;19664994;20068231;21406692;23186163;23481700;23584533;24275569;24714562;24715725;25576301;25645385;25698737;25813380;26728094;27862975;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29508533;29557506;29632046;29632711;29786170;29789417;30157172;30315122;30429286;30524438;30779550;31154438;31530632;31611695;31653868;31844290;31848261;31937595;32157095;32350084;32387766;32502341;32938616;33298915;33592498;33968037;34171305;34185709;34509645;34561969;35051231;35251023;35580925;36010968;36215666;36284347;37142673;37916886;37938771;38621504;38665916",
        "class_list": "",
        "function": "Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride (By similarity). Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival (By similarity) (PubMed:25698737, PubMed:30157172, PubMed:37142673)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Mutation and clinical analysis of the CLCC1 gene in amyotrophic lateral sclerosis patients from Central South China., [RefSeq, PubMed]; Unraveling the CLCC1 interactome: Impact of the Asp25Glu variant and its interaction with SigmaR1 at the Mitochondrial-Associated ER Membrane (MAM)., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 8,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 8,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 8,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 10,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O94861;Q8WYP8;Q8WYP9;Q9BU25",
        "ec_number_list": "1.8.-.-;1.8.5.1;1.11.1.-;5.6.1.6",
        "go_molecular_function": "GO:0005254 chloride channel activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site;GO:0034707 chloride channel complex",
        "go_biological_process": "GO:0032469 endoplasmic reticulum calcium ion homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "Q96S66-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BPX7-1",
        "uniprot_id": "CG025_HUMAN",
        "mass": 46451.0,
        "length": 421,
        "protein_name": "UPF0415 protein C7orf25",
        "gene_name": "C7orf25",
        "organism": "Human",
        "refseq_name": "UPF0415 protein C7orf25",
        "refseq_ac": "NP_076959",
        "gene_names_uniprotkb": "C7orf25",
        "gene_names_refseq": "C7orf25",
        "protein_names_uniprotkb": "UPF0415 protein C7orf25",
        "protein_names_refseq": "UPF0415 protein C7orf25",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79020)",
        "pathway_count": 1,
        "publication_count": 31,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;17081983;18452278;23481700;25645385;26992070;28228285;28832583;28834231;28904123;29242379;29485866;29557506;30484775;31844290;32157095;32938616;32983136;33592498;33717175;33912179;33968037;34171305;34357683;34932366;35051231;35580925;36010968;36215666;36241641",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D1V2;J3KR36;Q9H779",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "Q9BPX7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H2J1-1",
        "uniprot_id": "CI037_HUMAN",
        "mass": 18048.0,
        "length": 176,
        "protein_name": "Uncharacterized protein ARRDC1-AS1",
        "gene_name": "ARRDC1-AS1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "ARRDC1-AS1; AD038; C9orf37",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Uncharacterized protein ARRDC1-AS1; ARRDC1 antisense RNA 1; ARRDC1 antisense gene protein 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "10931946;26154972;27893789;30379171;32938616",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q17RM5;Q5T368",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q9H2J1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NZ45-1",
        "uniprot_id": "CISD1_HUMAN",
        "mass": 12199.0,
        "length": 108,
        "protein_name": "CDGSH iron-sulfur domain-containing protein 1",
        "gene_name": "CISD1",
        "organism": "Human",
        "refseq_name": "CDGSH iron-sulfur domain-containing protein 1",
        "refseq_ac": "NP_060934",
        "gene_names_uniprotkb": "CISD1; C10orf70; MDS029; ZCD1",
        "gene_names_refseq": "C10orf70; CISD1; MDS029; ZCD1; mitoNEET",
        "protein_names_uniprotkb": "CDGSH iron-sulfur domain-containing protein 1; 2.6.1.3; Cysteine transaminase CISD1; MitoNEET",
        "protein_names_refseq": "CDGSH iron-sulfur domain-containing protein 1; cysteine transaminase CISD1; zinc finger CDGSH-type domain 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55847)",
        "pathway_count": 1,
        "publication_count": 48,
        "publication_id_list": "16385451;17376863;17584744;17766439;17766440;17905743;18047834;19580816;21788481;22645359;23758282;24714562;25469497;25621951;26024233;26728094;26992070;27846572;27920218;28063628;28218747;28228285;28510447;28834231;29242379;29393594;29437277;29493099;29557506;29632046;30315122;30410026;31530632;31844290;32157095;32265295;32357974;32387766;33633747;33912179;34357683;35251023;35318648;36194135;36215666;36671422;36995520;38527404",
        "class_list": "",
        "function": "Biophysical properties of mitoNEET suggest that it may participate in a redox-sensitive signaling and/or in Fe-S cluster transfer, [RefSeq, PubMed]; CISD1 Is a Breast Cancer Prognostic Biomarker Associated with Diabetes Mellitus. Publication Status: Online-Only, [RefSeq, PubMed]; Crystal structure of mitoNEET reveals distinct groups of iron sulfur proteins., [RefSeq, PubMed]; L-cysteine transaminase that catalyzes the reversible transfer of the amino group from L-cysteine to the alpha-keto acid 2-oxoglutarate to respectively form 2-oxo-3-sulfanylpropanoate and L-glutamate (PubMed:36194135). The catalytic cycle occurs in the presence of pyridoxal 5'-phosphate (PLP) cofactor that facilitates transamination by initially forming an internal aldimine with the epsilon-amino group of active site Lys-55 residue on the enzyme (PLP-enzyme aldimine), subsequently displaced by formation of an external aldimine with the substrate amino group (PLP-L-cysteine aldimine). The external aldimine is further deprotonated to form a carbanion intermediate, which in the presence of 2-oxoglutarate regenerates PLP yielding final products 2-oxo-3-sulfanylpropanoate and L-glutamate. The proton transfer in carbanion intermediate is suggested to be controlled by the active site lysine residue, whereas PLP stabilizes carbanion structure through electron delocalization, also known as the electron sink effect (PubMed:36194135). Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in iron-sulfur cluster shuttling and/or in redox reactions. Can transfer the [2Fe-2S] cluster to an apo-acceptor protein only when in the oxidation state, likely serving as a redox sensor that regulates mitochondrial iron-sulfur cluster assembly and iron trafficking upon oxidative stress (PubMed:17584744, PubMed:21788481, PubMed:23758282)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Mito- NEET is an important iron-containing protein involved in the control of maximal mitochondrial respiratory rates, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Overexpression of ferroptosis-related genes FSP1 and CISD1 is related to prognosis and tumor immune infiltration in gastric cancer., [RefSeq, PubMed]; Regulations of mitoNEET by the key redox homeostasis molecule glutathione., [RefSeq, PubMed]; Spectroscopic studies show that the 2Fe-2S cluster is coordinated by Cys-3 and His-1. The His ligand is shown to be involved in the observed pH lability of the cluster, indicating that loss of this ligand via protonation triggered release of the cluster., [RefSeq, PubMed]; This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. The encoded protein has been localized to the outer membrane of mitochondria and is thought to play a role in regulation of oxidation. Genes encoding similar proteins are located on chromosomes 4 and 17, and a pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Feb 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q1X902",
        "ec_number_list": "2.6.1.1;2.6.1.3",
        "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0047801 L-cysteine transaminase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane",
        "go_biological_process": "GO:0010506 regulation of autophagy;GO:0006879 intracellular iron ion homeostasis;GO:0051604 protein maturation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.1,
        "record_id": "Q9NZ45-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9P2D1-1",
        "uniprot_id": "CHD7_HUMAN",
        "mass": 335927.0,
        "length": 2997,
        "protein_name": "ATP-dependent chromatin remodeler CHD7",
        "gene_name": "CHD7",
        "organism": "Human",
        "refseq_name": "ATP-dependent chromatin remodeler CHD7 isoform 2",
        "refseq_ac": "NP_001303619",
        "gene_names_uniprotkb": "CHD7; KIAA1416",
        "gene_names_refseq": "CHD7; CRG; HH5; IS3; KAL5",
        "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD7; 3.6.4.-; CHD-7; Chromo domain-containing protein 7",
        "protein_names_refseq": "ATP-dependent chromatin remodeler CHD7 isoform 2; ATP-dependent chromatin remodeler CHD7; ATP-dependent helicase CHD7; CHARGE association; chromo domain-containing protein 7",
        "tax_id": 9606,
        "disease": "CHARGE syndrome (Disease Ontology:DOID:0050834); autism spectrum disorder (Disease Ontology:DOID:0060041); hypogonadotropic hypogonadism 5 with or without anosmia (Disease Ontology:DOID:0090084); congenital heart disease (Disease Ontology:DOID:1682); scoliosis, isolated, susceptibility to, 3 (MONDO:MONDO:0012115)",
        "pathway": " (hsa:55636);  (R-HSA-9943962)",
        "pathway_count": 2,
        "publication_count": 127,
        "publication_id_list": "10.1101/2023.09.13.557529;10921920;11237011;11274398;11356022;11507205;11744694;15300250;15960975;16095617;16400610;16763960;16878130;16949368;17027977;17143291;17350655;17436250;17525332;17603073;18074359;18378692;18445044;18452278;18669648;18834967;19021638;19413330;19651622;19664994;19664995;19690332;20058876;20068231;20453063;21158681;21406692;21554267;21899694;21931733;21995344;22461308;22462537;22646239;23186163;23285124;23408615;23481700;24129315;24366607;24397554;24714562;24715725;25077900;25418920;25576301;25645385;25818041;25880248;26154972;26375851;26728094;26811146;26992070;27503676;27600516;27846572;27862975;27920218;28121444;28228285;28533432;28649982;28832583;28834231;28904123;29242379;29351928;29393594;29493099;29508533;29557506;29632046;29786170;29789417;30315122;30379171;30484775;30524438;30779550;31154438;31530632;31844290;31998317;32157095;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33323470;33392160;33592498;33912179;33936100;33968037;33981976;34171305;34211107;34405274;34509645;34932366;35051231;35289036;35580925;36215666;36228153;36241641;38253038;38408234;38790272;39531497;39534244;6261960",
        "class_list": "",
        "function": "ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production., [UniProtKB, PubMed, PubMed]; CHD7 Disorder-Not CHARGE Syndrome-Presenting as Isolated Cochleovestibular Dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]; CHD7 and SOX2 act in a common gene regulatory network during mammalian semicircular canal and cochlear development., [RefSeq, PubMed]; This gene encodes a protein that contains several helicase family domains. Mutations in this gene have been found in some patients with the CHARGE syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 8,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 8,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 8,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 36,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 90,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 5,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D0VBA5;E9PNZ2;Q05DI5;Q2TAN4;Q66K35;Q7Z6C0;Q7Z7Q2;Q9NXA0;Q9NXA3",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin",
        "go_biological_process": "GO:0021545 cranial nerve development;GO:0043584 nose development;GO:0048806 genitalia development;GO:0060123 regulation of growth hormone secretion;GO:0001701 in utero embryonic development",
        "synthesized_glycan_count": 0,
        "hit_score": 14.1,
        "record_id": "Q9P2D1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UJ71-1",
        "uniprot_id": "CLC4K_HUMAN",
        "mass": 36725.0,
        "length": 328,
        "protein_name": "C-type lectin domain family 4 member K",
        "gene_name": "CD207",
        "organism": "Human",
        "refseq_name": "C-type lectin domain family 4 member K",
        "refseq_ac": "NP_056532",
        "gene_names_uniprotkb": "CD207; CLEC4K",
        "gene_names_refseq": "CD207; CLEC4K",
        "protein_names_uniprotkb": "C-type lectin domain family 4 member K; Langerin",
        "protein_names_refseq": "C-type lectin domain family 4 member K; C-type lectin domain family 4, member K; CD207 antigen, langerin; CD207 molecule, langerin; Langerhans cell specific c-type lectin",
        "tax_id": 9606,
        "disease": "Birbeck granule deficiency (MONDO:MONDO:0013251)",
        "pathway": " (hsa:50489);  (R-HSA-1236978)",
        "pathway_count": 2,
        "publication_count": 38,
        "publication_id_list": "10.1101/2023.09.13.557529;10661407;12061891;12352970;12626394;14610287;14991068;15222130;15489334;15592474;15815621;15816828;16567809;16818754;17334373;18061677;18249105;19175323;19317650;19690332;20026605;20028659;20097424;20181944;21112338;24217250;25144207;25650933;29272097;31141812;31607745;32296183;33989634;34935212;35051231;35758632;36010968;7798619",
        "class_list": "glycogene",
        "function": "CD1a and langerin have roles in antigen presentation to T cells, [RefSeq, PubMed]; Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Langerin (CD207) represents a novel interferon-stimulated gene in Langerhans cells., [RefSeq, PubMed]; Langerin is a potent langerhans cells -specific regulator of membrane superimposition and zippering, representing a key molecule to trace Langerhans cells [Review]. Review article, [RefSeq, PubMed]; Langerin was expressed by Langerhans cells, [RefSeq, PubMed]; Origin of langerin (CD207)-expressing antigen presenting cells in the normal oral mucosa and in oral lichen planus lesions., [RefSeq, PubMed]; The Langerin-positive cells strictly colonized the epidermis and no cells were found in the dermis., [RefSeq, PubMed]; The effects of the amino acid changes on the activity of langerin were examined by expressing each of the polymorphic forms., [RefSeq, PubMed]; The molecular basis for the pH-dependent calcium affinity of the pattern recognition receptor langerin., [RefSeq, PubMed]; The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 476,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0005537 D-mannose binding;GO:0038187 pattern recognition receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0030669 clathrin-coated endocytic vesicle membrane;GO:0031901 early endosome membrane;GO:0030139 endocytic vesicle",
        "go_biological_process": "GO:0006955 immune response;GO:0051607 defense response to virus",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "Q9UJ71-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UQC9-1",
        "uniprot_id": "CLCA2_HUMAN",
        "mass": 103941.0,
        "length": 943,
        "protein_name": "Calcium-activated chloride channel regulator 2",
        "gene_name": "CLCA2",
        "organism": "Human",
        "refseq_name": "calcium-activated chloride channel regulator 2 preproprotein",
        "refseq_ac": "NP_006527",
        "gene_names_uniprotkb": "CLCA2; CACC3",
        "gene_names_refseq": "CACC3; CACC; CLCA2; CLCRG2; CaCC-3",
        "protein_names_uniprotkb": "Calcium-activated chloride channel regulator 2; 3.4.-.-; CaCC-3; Calcium-activated chloride channel family member 2; Calcium-activated chloride channel protein 3; hCLCA2; hCaCC-3",
        "protein_names_refseq": "CLCA family member 2, chloride channel regulator; calcium-activated chloride channel protein 3; calcium-activated chloride channel regulator 2 preproprotein; calcium-activated chloride channel regulator 2; chloride channel, calcium activated, family member 2",
        "tax_id": 9606,
        "disease": "nephrotic syndrome (Disease Ontology:DOID:1184); beta-ketothiolase deficiency (Disease Ontology:DOID:14723); arteriosclerosis (Disease Ontology:DOID:2349); carbohydrate metabolic disorder (Disease Ontology:DOID:2978); end stage renal disease (Disease Ontology:DOID:783); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:9635);  (R-HSA-2672351)",
        "pathway_count": 2,
        "publication_count": 113,
        "publication_id_list": "10362588;10437792;10554024;10564087;10642508;10720933;10767424;10830164;10831588;11182090;11262615;11320086;11445004;11588175;11687798;11734858;11842292;11904445;11956057;12393854;12907679;1379744;14584882;14634667;14966209;15010458;15044642;15147738;15318163;15504734;15505377;15707651;15916532;15919655;16158324;16219661;16813530;16849430;16850186;16873362;16959974;17381423;17448995;17699613;17881003;18000046;18063579;18310267;18400985;18449189;18508966;18662336;18724360;19153159;19307298;19380724;19387438;19620632;19808995;19953639;20388639;20466723;20525693;20538786;21040849;21527911;21984732;22002868;22773952;22946059;2298749;23090970;23112050;2321095;23616951;23719902;24190977;2536303;26359375;26562072;28071645;28154142;28790369;29351928;29741879;29786170;31154438;32157095;32298355;32387766;33966732;35051231;35580925;36280802;38528613;38602325;7588753;7665160;7795595;8041726;8112288;8383669;8533761;8544406;8626462;8809036;9037075;9395096;9571199;9662395;9700209;9719863;9744806",
        "class_list": "",
        "function": "CLCA2 overexpression suppresses epithelial-to-mesenchymal transition in cervical cancer cells through inactivation of ERK/JNK/p38-MAPK signaling pathways. Publication Status: Online-Only, [RefSeq, PubMed]; CLCA2 was identified as a potential prognostic marker for triple negative breast cancer in African American women. Publication Status: Online-Only, [RefSeq, PubMed]; Decreased expression of CLCA2 and the correlating with immune infiltrates in patients with cervical squamous cell carcinoma: A bioinformatics analysis., [RefSeq, PubMed]; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; TP63 truncating mutation causes increased cell apoptosis and premature ovarian insufficiency by enhanced transcriptional activation of CLCA2. Erratum:[J Ovarian Res. 2024 Apr 29;17(1):93. PMID: 38685112] Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. [provided by RefSeq, Sep 2016]., [RefSeq]; Transport of CLCA2 to the nucleus by extracellular vesicles controls keratinocyte survival and migration., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 49,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 13,
        "disease_count": 6,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2T3;Q9Y6N2",
        "ec_number_list": "3.4.-.-",
        "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0005254 chloride channel activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0009925 basal plasma membrane;GO:0070161 anchoring junction",
        "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0034220 monoatomic ion transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 13.5,
        "record_id": "Q9UQC9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A096LNP1-1",
        "uniprot_id": "D131B_HUMAN",
        "mass": 8156.0,
        "length": 70,
        "protein_name": "Beta-defensin 131B",
        "gene_name": "DEFB131B",
        "organism": "Human",
        "refseq_name": "beta-defensin 131B precursor",
        "refseq_ac": "NP_001229782",
        "gene_names_uniprotkb": "DEFB131B",
        "gene_names_refseq": "DEFB131B",
        "protein_names_uniprotkb": "Beta-defensin 131B; Defensin, beta 131",
        "protein_names_refseq": "beta-defensin 131B precursor; beta-defensin 131B; defensin, beta 131",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100129216)",
        "pathway_count": 1,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "Has antibacterial activity., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0045087 innate immune response;GO:0042742 defense response to bacterium",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "A0A096LNP1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9C098-1",
        "uniprot_id": "DCLK3_HUMAN",
        "mass": 73814.0,
        "length": 648,
        "protein_name": "Serine/threonine-protein kinase DCLK3",
        "gene_name": "DCLK3",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein kinase DCLK3 isoform 2",
        "refseq_ac": "NP_208382",
        "gene_names_uniprotkb": "DCLK3; DCAMKL3; DCDC3C; KIAA1765",
        "gene_names_refseq": "CLR; DCAMKL3; DCDC3C; DCK3; DCLK3",
        "protein_names_uniprotkb": "Serine/threonine-protein kinase DCLK3; 2.7.11.1; Doublecortin domain-containing protein 3C; Doublecortin-like and CAM kinase-like 3; Doublecortin-like kinase 3",
        "protein_names_refseq": "CLICK-I,II-related; doublecortin and CaM kinase-like 3; doublecortin domain-containing protein 3C; doublecortin-like and CAM kinase-like 3; serine/threonine-protein kinase DCLK3 isoform 2; serine/threonine-protein kinase DCLK3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:85443)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11237011;17344846;29557506;31154438;36215666;37938771",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0035556 intracellular signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q9C098-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A6NH13-1",
        "uniprot_id": "DAS1_HUMAN",
        "mass": 15587.0,
        "length": 148,
        "protein_name": "Putative uncharacterized protein DNAJC9-AS1",
        "gene_name": "DNAJC9-AS1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DNAJC9-AS1; C10orf103",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative uncharacterized protein DNAJC9-AS1; DNAJC9 antisense RNA 1; DNAJC9 antisense gene protein 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "A6NH13-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A8MXU0-1",
        "uniprot_id": "DB108_HUMAN",
        "mass": 8390.0,
        "length": 73,
        "protein_name": "Putative beta-defensin 108A",
        "gene_name": "DEFB108A; DEFB108C",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DEFB108A; DEFB108C; DEFB108P1; DEFB108P2",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative beta-defensin 108A; Defensin, beta 108A; Defensin, beta 108C; Putative beta-defensin 108B pseudogene 1/2",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (R-HSA-1461957)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10521347;10914484;11085990;11237011;11702237;11934878;12734011;18006661;20483750;21122132;9541493",
        "class_list": "",
        "function": "Has antibacterial activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0045087 innate immune response;GO:0042742 defense response to bacterium",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "A8MXU0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NBQ5-1",
        "uniprot_id": "DHB11_HUMAN",
        "mass": 32964.0,
        "length": 300,
        "protein_name": "Estradiol 17-beta-dehydrogenase 11",
        "gene_name": "HSD17B11",
        "organism": "Human",
        "refseq_name": "estradiol 17-beta-dehydrogenase 11 precursor",
        "refseq_ac": "NP_057329",
        "gene_names_uniprotkb": "HSD17B11; DHRS8; PAN1B; PRO233; PSEC0029; SDR16C2",
        "gene_names_refseq": "17-BETA-HSD11; 17-BETA-HSDXI; 17BHSD11; DHRS8; HSD17B11; PAN1B; RETSDR2; SDR16C2",
        "protein_names_uniprotkb": "Estradiol 17-beta-dehydrogenase 11; 1.1.1.62; 17-beta-HSD 11; 17-beta-HSD XI; 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-hydroxysteroid dehydrogenase XI; 17bHSD11; 17betaHSD11; 17betaHSDXI; CTCL-associated antigen HD-CL-03; Cutaneous T-cell lymphoma-associated antigen HD-CL-03; Dehydrogenase/reductase SDR family member 8; Retinal short-chain dehydrogenase/reductase 2; Short chain dehydrogenase/reductase family 16C member 2; retSDR2",
        "protein_names_refseq": "17-beta-hydroxysteroid dehydrogenase type XI; CTCL tumor antigen HD-CL-03; CTCL-associated antigen HD-CL-03; cutaneous T-cell lymphoma-associated antigen HD-CL-03; dehydrogenase/reductase SDR family member 8; estradiol 17-beta-dehydrogenase 11 precursor; estradiol 17-beta-dehydrogenase 11; retinal short-chain dehydrogenase/reductase 2; short chain dehydrogenase/reductase family 16C member 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51170);  (R-HSA-193144)",
        "pathway_count": 2,
        "publication_count": 34,
        "publication_id_list": "10800688;11165019;11237011;11895893;12404296;12697717;12975309;14996095;16303743;16332571;17067289;1825337;19027824;2149502;2171939;22792371;25577493;25645385;26230928;26472732;30315122;31154438;31848261;34019948;37217939;37938771;38253038;39259123;40596516;7336466;8076586;8099587;9783542;9888557",
        "class_list": "",
        "function": "Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma., [UniProtKB]; Ferroptosis-related genes DUOX1 and HSD17B11 affect tumor microenvironment and predict overall survival of lung adenocarcinoma patients., [RefSeq, PubMed]; Knowledge of its in vitro activity together with a newly described expression pattern at the protein level in tissues involved in steroidogenesis and detoxification could suggest a potential role of DHRS8 in vivo, [RefSeq, PubMed]; Role for 17-beta-HSDXI in androgen metabolism during steroidogenesis., [RefSeq, PubMed]; Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96HF6;Q9UKU4",
        "ec_number_list": "1.1.1.300;1.1.1.-;1.1.1.64;1.1.1.54;1.1.1.216;1.1.1.62;1.1.1.239;1.1.1.105;1.1.1.209;1.1.1.53;1.1.1.51;1.1.1.225;1.1.1.357;1.1.1.210;1.1.1.188;1.1.1.112;1.3.1.20;1.1.1.270;1.1.1.149;1.1.1.330;1.1.1.n12;1.1.1.35;1.1.1.178;1.1.1.159",
        "go_molecular_function": "GO:0016229 steroid dehydrogenase activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005829 cytosol",
        "go_biological_process": "GO:0006710 androgen catabolic process;GO:0006703 estrogen biosynthetic process;GO:0006694 steroid biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "Q8NBQ5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BTE7-1",
        "uniprot_id": "DCNL5_HUMAN",
        "mass": 27508.0,
        "length": 237,
        "protein_name": "DCN1-like protein 5",
        "gene_name": "DCUN1D5",
        "organism": "Human",
        "refseq_name": "DCN1-like protein 5 isoform a",
        "refseq_ac": "NP_115675",
        "gene_names_uniprotkb": "DCUN1D5; SCCRO5",
        "gene_names_refseq": "DCNL5; DCUN1D5; SCCRO5",
        "protein_names_uniprotkb": "DCN1-like protein 5; DCNL5; DCUN1 domain-containing protein 5; Defective in cullin neddylation protein 1-like protein 5; Squamous cell carcinoma-related oncogene 5",
        "protein_names_refseq": "DCN1, defective in cullin neddylation 1, domain containing 5; DCN1-like protein 5 isoform a; DCN1-like protein 5; DCUN1 domain-containing protein 5; defective in cullin neddylation protein 1-like protein 5; squamous cell carcinoma-related oncogene 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84259);  (R-HSA-8951664)",
        "pathway_count": 2,
        "publication_count": 151,
        "publication_id_list": "10535940;10597293;10811609;10878807;10973499;11069780;11237011;11259415;11292861;11292862;11454738;11585840;11733065;11961546;12101228;12186903;12504025;12504026;12526791;12538644;12609982;12682069;12759363;12816948;14690597;14757770;15282312;15361859;15367669;15537541;15572695;15574592;15601839;15652483;15688063;15694336;15799966;16171779;16401342;16533400;16547496;16647857;16707496;16790436;16943200;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18093314;18206966;18445686;18669648;18767875;18775313;18776931;18805092;18826954;18851830;18926707;19250909;19321346;19617556;19651622;19664994;19748355;20068231;20230923;21406692;21447816;21463634;21778237;21863050;21940857;22306028;22466964;22537386;22959436;23098533;23186163;23201271;23333871;23401859;23453757;23535662;23535663;23563313;23583660;23912815;23986495;24076655;24192928;24366543;24636985;24793695;24793696;25314029;25349211;25355947;25531226;26154972;26344709;26460955;26632597;26906416;26992070;27030794;27222660;27565346;28115426;28510447;29153394;29437277;29493099;29557506;29958295;30379171;30429286;30484775;30610225;31668094;31844290;32005965;32157095;32284348;32357974;32488085;32938616;33444648;33592498;33691108;33717175;33912179;34019948;34171305;34932366;35051231;35318648;35561310;35580925;36215666;36284347;36581221;37938771;38831379;9790970;9887101;9891082",
        "class_list": "",
        "function": "All reported DCN1 inhibitors are able to induce remarkable accumulation of cullin 3 and its substrate NRF2, indicating therapeutic potential of DCN1 inhibitors for human diseases that may benefit from upregulation of cullin 3 and NRF2, [RefSeq, PubMed]; Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs) (PubMed:19617556, PubMed:23201271, PubMed:26906416). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth (PubMed:23098533, PubMed:24192928)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Evidence that DCNL5 may be involved in innate immunity, as it is a direct substrate of the kinase IKKalpha during immune signalling. Publication Status: Online-Only, [RefSeq, PubMed]; Overexpression of DCUN1D5 is associated with laryngeal squamous cell carcinoma., [RefSeq, PubMed]; YY1 mediated DCUN1D5 transcriptional activation promotes triple-negative breast cancer progression by targeting FN1/PI3K/AKT pathway. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3ZTT2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0032182 ubiquitin-like protein binding;GO:0097602 cullin family protein binding;GO:0031624 ubiquitin conjugating enzyme binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005819 spindle;GO:0000151 ubiquitin ligase complex",
        "go_biological_process": "GO:0006974 DNA damage response;GO:0001558 regulation of cell growth;GO:0045116 protein neddylation;GO:2000436 positive regulation of protein neddylation;GO:2000434 regulation of protein neddylation",
        "synthesized_glycan_count": 0,
        "hit_score": 15.4,
        "record_id": "Q9BTE7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WUS8-1",
        "uniprot_id": "D42E1_HUMAN",
        "mass": 44284.0,
        "length": 393,
        "protein_name": "Short-chain dehydrogenase/reductase family 42E member 1",
        "gene_name": "SDR42E1",
        "organism": "Human",
        "refseq_name": "short-chain dehydrogenase/reductase family 42E member 1",
        "refseq_ac": "NP_660151",
        "gene_names_uniprotkb": "SDR42E1; HSPC105",
        "gene_names_refseq": "HSPC105; SDR42E1",
        "protein_names_uniprotkb": "Short-chain dehydrogenase/reductase family 42E member 1; 1.1.1.-",
        "protein_names_refseq": "short-chain dehydrogenase/reductase family 42E member 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:93517)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "11237011;19027726;23481700;25576301;29242379;30524438;31844290;32357974;33537174;33936100;33968037;34133966;35580925;36010968;37938771;38160768;39531497",
        "class_list": "",
        "function": "Identification of the novel SDR42E1 gene that affects steroid biosynthesis associated with the oculocutaneous genital syndrome., [RefSeq, PubMed]; In silico characterization of the novel SDR42E1 as a potential vitamin D modulator., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDS1;Q9P0D1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "GO:0006694 steroid biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q8WUS8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96B18-1",
        "uniprot_id": "DACT3_HUMAN",
        "mass": 64949.0,
        "length": 629,
        "protein_name": "Dapper homolog 3",
        "gene_name": "DACT3",
        "organism": "Human",
        "refseq_name": "dapper homolog 3 isoform 2",
        "refseq_ac": "NP_001287975",
        "gene_names_uniprotkb": "DACT3; RRR1",
        "gene_names_refseq": "DACT3; DAPPER3; RRR1",
        "protein_names_uniprotkb": "Dapper homolog 3; Antagonist of beta-catenin Dapper homolog 3; Arginine-rich region 1 protein; Dapper antagonist of catenin 3",
        "protein_names_refseq": "antagonist of beta-catenin Dapper homolog 3; arginine-rich region 1 protein; dapper homolog 3 isoform 2; dapper, antagonist of beta-catenin, homolog 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:147906)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;16881060;18538736;19664994;23186163;25576301;29557506;30379171;32265295;32897882;33054518;33298915;35051231;35187752",
        "class_list": "",
        "function": "Butyrate mediates anti-inflammatory effects of Faecalibacterium prausnitzii in intestinal epithelial cells through Dact3., [RefSeq, PubMed]; DACT3 has a tumor-inhibiting role in acute myeloid leukemia via the suppression of Wnt/beta-catenin signaling by DVL2., [RefSeq, PubMed]; Epigenetic repression of DACT3 leads to aberrant Wnt-beta-catenin signaling in colorectal cancer cells., [RefSeq, PubMed]; May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0005080 protein kinase C binding;GO:0051018 protein kinase A binding;GO:0070097 delta-catenin binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0030308 negative regulation of cell growth;GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q96B18-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0C7V8-1",
        "uniprot_id": "DC8L2_HUMAN",
        "mass": 71191.0,
        "length": 631,
        "protein_name": "DDB1- and CUL4-associated factor 8-like protein 2",
        "gene_name": "DCAF8L2",
        "organism": "Human",
        "refseq_name": "DDB1- and CUL4-associated factor 8-like protein 2",
        "refseq_ac": "NP_001340377",
        "gene_names_uniprotkb": "DCAF8L2; WDR42C",
        "gene_names_refseq": "DCAF8L2; WDR42C",
        "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 8-like protein 2; WD repeat-containing protein 42C",
        "protein_names_refseq": "DDB1- and CUL4-associated factor 8-like protein 2; WD repeat domain 42C; WD repeat-containing protein 42C",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:347442)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "11237011;28218747;29557506;31844290",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RXH9;J3KT06",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0080008 Cul4-RING E3 ubiquitin ligase complex",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "P0C7V8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N907-1",
        "uniprot_id": "DAND5_HUMAN",
        "mass": 20180.0,
        "length": 189,
        "protein_name": "DAN domain family member 5",
        "gene_name": "DAND5",
        "organism": "Human",
        "refseq_name": "DAN domain family member 5 precursor",
        "refseq_ac": "NP_689867",
        "gene_names_uniprotkb": "DAND5; CER2; CKTSF1B3; COCO; GREM3; SP1",
        "gene_names_refseq": "CER2; CERL2; CKTSF1B3; COCO; CRL2; DAND5; DANTE; GREM3; HTX13; SP1",
        "protein_names_uniprotkb": "DAN domain family member 5; Cerberus-like protein 2; Cerl-2; Cysteine knot superfamily 1, BMP antagonist 3; Gremlin-3",
        "protein_names_refseq": "DAN domain family member 5 precursor; DAN domain family member 5, BMP antagonist; DAN domain family, member 5; cerberus 2; cerberus-like 2; cerberus-like protein 2; cerl-2; cysteine knot superfamily 1, BMP antagonist 3; gremlin-3",
        "tax_id": 9606,
        "disease": "visceral heterotaxy 13 (Disease Ontology:DOID:0051027)",
        "pathway": " (hsa:199699);  (R-HSA-1181150);  (R-HSA-1433617)",
        "pathway_count": 3,
        "publication_count": 44,
        "publication_id_list": "10067895;10473623;10822381;10934479;11024047;11237011;11294908;11389842;11485994;11779503;11779505;12063393;12592392;14978253;15062104;15150278;15254711;15350224;15485907;15531507;16260601;17272273;19114992;20694664;21356369;21383881;21532621;22901808;25603319;26908452;28738792;30685069;31844290;31869685;33587337;34215651;35051231;36316122;40596516;8878477;9288972;9311995;9670020;9702198",
        "class_list": "",
        "function": "A gain-of-function cDNA screen reveals that Coco, a secreted antagonist of TGF-beta ligands, induces dormant breast cancer cells to undergo reactivation in the lung. Erratum:[Cell. 2012 Dec 7;151(6):1386-8], [RefSeq, PubMed]; A novel biallelic loss-of-function variant in DAND5 causes heterotaxy syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; Antagonist of the extracellular signaling protein NODAL, which is required for correct left-right patterning during embryonic development (By similarity). Antagonist of BMP and TGF-beta signaling (PubMed:33587337). Independently of its role in left-right axis establishment, plays a role during heart development, possibly through the regulation of TGF-beta/Nodal signaling pathway (By similarity). Displays anti-angiogenic activity by inhibiting endothelial sprouting, migration, and proliferation. Once internalized by endothelial cells, may alter their redox and glycolytic balance (PubMed:33587337)., [UniProtKB, UniProtKB, PubMed]; Coco may be a player in the bone morphogenetic protein dysregulation and the tissue repair failure in multiple sclerosis, [RefSeq, PubMed]; Generation of a gene-corrected human induced pluripotent stem cell line derived from a patient with laterality defects and congenital heart anomalies with a c.455G > A alteration in DAND5., [RefSeq, PubMed]; High DAND5 expression is associated with tumor growth and angiogenesis in breast cancer., [RefSeq, PubMed]; In this work, we report two patients with a DAND5 heterozygous non-synonymous variant (c.455G > A) in the functional domain of the DAND5 protein (p.R152H), a master regulator of Nodal signaling. Patient 1 presents left isomerism, ventricular septal defect with overriding aorta and pulmonary atresia, while patient 2 presents ventricular septal defect with overriding aorta, right ventricular hypertrophy Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0038100 nodal binding;GO:0016015 morphogen activity;GO:0140311 protein sequestering activity;GO:0141069 receptor ligand inhibitor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0003140 determination of left/right asymmetry in lateral mesoderm;GO:1900108 negative regulation of nodal signaling pathway;GO:0030514 negative regulation of BMP signaling pathway;GO:0038092 nodal signaling pathway;GO:0003281 ventricular septum development",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "Q8N907-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15075-1",
        "uniprot_id": "DCLK1_HUMAN",
        "mass": 82224.0,
        "length": 740,
        "protein_name": "Serine/threonine-protein kinase DCLK1",
        "gene_name": "DCLK1",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein kinase DCLK1 isoform 2",
        "refseq_ac": "NP_001182344",
        "gene_names_uniprotkb": "DCLK1; DCAMKL1; DCDC3A; KIAA0369",
        "gene_names_refseq": "CL1; CLICK1; DCAMKL1; DCDC3A; DCLK1; DCLK",
        "protein_names_uniprotkb": "Serine/threonine-protein kinase DCLK1; 2.7.11.1; Doublecortin domain-containing protein 3A; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1",
        "protein_names_refseq": "doublecortin domain-containing protein 3A; doublecortin-like and CAM kinase-like 1; serine/threonine-protein kinase DCLK1 isoform 2; serine/threonine-protein kinase DCLK1",
        "tax_id": 9606,
        "disease": "dyslexia (Disease Ontology:DOID:4428)",
        "pathway": " (hsa:9201)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "10.1101/2023.09.13.557529;10036192;10051403;11237011;16548883;17344846;19531498;21406692;25645385;27397612;29557506;30429286;31154438;31222486;31844290;31848261;32157095;32938616;33592498;33912179;33968037;33981976;35051231;35318648;35580925;36010968;36284347;37487255;37996782;38007147;38821583;39288218;9747029",
        "class_list": "",
        "function": "DCLK1 Expression and its Functional Significance in Intrahepatic Cholangiocarcinoma and Bil-IN Stage., [RefSeq, PubMed]; DCLK1 and its oncogenic functions: A promising therapeutic target for cancers. Review article, [RefSeq, PubMed]; DCLK1 induces a pro-tumorigenic phenotype to drive gastric cancer progression., [RefSeq, PubMed]; Exosomes from metastatic colon cancer cells drive the proliferation and migration of primary colon cancer through increased expression of cancer stem cell markers CD133 and DCLK1., [RefSeq, PubMed]; Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system., [UniProtKB]; Role of DCLK1/Hippo pathway in type II alveolar epithelial cells differentiation in acute respiratory distress syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 19,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 55,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z3E9;Q5VZY8;Q5VZZ0;Q5VZZ1",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity;GO:0008017 microtubule binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043005 neuron projection",
        "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007399 nervous system development;GO:0035556 intracellular signal transduction;GO:0007417 central nervous system development;GO:0009615 response to virus",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "O15075-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75912-2",
        "uniprot_id": "DGKI_HUMAN",
        "mass": 116233.0,
        "length": 1057,
        "protein_name": "Diacylglycerol kinase iota",
        "gene_name": "DGKI",
        "organism": "Human",
        "refseq_name": "diacylglycerol kinase iota isoform 2",
        "refseq_ac": "NP_001308637",
        "gene_names_uniprotkb": "DGKI",
        "gene_names_refseq": "DGK-IOTA; DGKI",
        "protein_names_uniprotkb": "Diacylglycerol kinase iota; 2.7.1.107; DAG kinase iota; DGK-iota",
        "protein_names_refseq": "DAG kinase iota; diacylglycerol kinase iota isoform 2; diglyceride kinase iota",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9162);  (R-HSA-114508)",
        "pathway_count": 2,
        "publication_count": 35,
        "publication_id_list": "10706894;11080611;11413485;11805119;15894621;19033211;19065143;21119615;2175712;23949095;25233099;25576301;26154972;27920218;28218747;28649982;28832583;29242379;29331515;29393594;29508533;29557506;29632046;31844290;32387766;32502341;32938616;33141586;33298915;33392160;34087483;36059514;9601053;9830018;9930701",
        "class_list": "",
        "function": "Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:23949095, PubMed:9830018). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position (PubMed:9830018). By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Key molecules associated with thyroid carcinoma prognosis: A study based on transcriptome sequencing and GEO datasets. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The DGKI methylation status identified 22% of poorly responding patients in the low-risk group Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the type IV diacylglycerol kinase subfamily.  Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid.  The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A087WV00;A4D1Q9;Q9NZ49",
        "ec_number_list": "2.7.1.107;2.7.1.93;2.7.1.94;2.7.1.138",
        "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0046834 lipid phosphorylation;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction;GO:0030168 platelet activation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "O75912-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O94760-1",
        "uniprot_id": "DDAH1_HUMAN",
        "mass": 31122.0,
        "length": 285,
        "protein_name": "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1",
        "gene_name": "DDAH1",
        "organism": "Human",
        "refseq_name": "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform 2",
        "refseq_ac": "NP_001127917",
        "gene_names_uniprotkb": "DDAH1; DDAH",
        "gene_names_refseq": "DDAH-1; DDAH1; DDAHI; DDAH; HEL-S-16",
        "protein_names_uniprotkb": "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; 3.5.3.18; DDAH-1; DDAHI; Dimethylargininase-1; Dimethylarginine dimethylaminohydrolase 1",
        "protein_names_refseq": "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform 2; NG, NG-dimethylarginine dimethylaminohydrolase; dimethylargininase-1; epididymis secretory protein Li 16; n(G),N(G)-dimethylarginine dimethylaminohydrolase 1",
        "tax_id": 9606,
        "disease": "traumatic brain injury (Disease Ontology:DOID:0081292); dystonia 25 (Disease Ontology:DOID:0090055); hypertension (Disease Ontology:DOID:10763); cardiovascular system disease (Disease Ontology:DOID:1287); McCune Albright syndrome (Disease Ontology:DOID:1858); coronary artery disease (Disease Ontology:DOID:3393); dystonia (Disease Ontology:DOID:543)",
        "pathway": " (hsa:23576);  (R-HSA-203615)",
        "pathway_count": 2,
        "publication_count": 55,
        "publication_id_list": "10376602;10376603;10469573;10493931;10559837;10781589;11208594;11498544;11879202;11893755;11988487;12799359;14530264;15598505;16722822;16864653;17273169;18171027;18446211;19147491;19663506;20068231;20511233;21493890;21898353;24715725;25645385;26768311;28671819;29557506;31154438;31844290;32157095;32161166;32938616;33592498;33968037;34019948;34405274;35580925;36010968;36461077;37116560;37296100;37423418;38665916;39177258;7512951;8692835;8798458;9188442;9325253;9580552;9712842;9874257",
        "class_list": "",
        "function": "Dimethylarginine Dimethylaminohydrolase - 1 expression is increased under tBHP-induced oxidative stress regulates nitric oxide production in PCa cells attenuates mitochondrial ROS-mediated apoptosis., [RefSeq, PubMed]; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway., [RefSeq, PubMed]; Molecular Dynamics-Ensemble Docking and Biophysical Studies for Structure-Based Identification of Non-Amino Acidic Ligands of DDAH-1., [RefSeq, PubMed]; The effect of haptoglobin genotype on the association of asymmetric dimethylarginine and DDAH 1 polymorphism with diabetic macroangiopathy. Publication Status: Online-Only, [RefSeq, PubMed]; This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 7,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5HYC8;Q86XK5",
        "ec_number_list": "3.5.3.18",
        "go_molecular_function": "GO:0016403 dimethylargininase activity;GO:0046872 metal ion binding;GO:0003824 catalytic activity;GO:0016597 amino acid binding;GO:0030235 nitric-oxide synthase regulator activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0046209 nitric oxide metabolic process;GO:0008285 negative regulation of cell population proliferation;GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0043116 negative regulation of vascular permeability;GO:0045766 positive regulation of angiogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 5.8,
        "record_id": "O94760-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O94850-1",
        "uniprot_id": "DEND_HUMAN",
        "mass": 75996.0,
        "length": 711,
        "protein_name": "Dendrin",
        "gene_name": "DDN",
        "organism": "Human",
        "refseq_name": "dendrin",
        "refseq_ac": "NP_055901",
        "gene_names_uniprotkb": "DDN; KIAA0749",
        "gene_names_refseq": "DDN",
        "protein_names_uniprotkb": "Dendrin",
        "protein_names_refseq": "dendrin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23109)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "12559952;16464232;16751601;17251388;18356187;21606645;23143340;23667252;29393594;29557506;30458823;31844290;35580925;35767852;36284347",
        "class_list": "",
        "function": "In minimal change nephrotic syndrome, dendrin and ZO-1 are re-distributed within the podocytes. Whether this is a cause or a consequence of foot process effacement remains unclear., [RefSeq, PubMed]; Increasing number of dendrin-positive nuclei in the glomeruli suggest acute glomerular injury in IgA nephropathy., [RefSeq, PubMed]; Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity)., [UniProtKB]; Relocation of dendrin to the podocyte nuclei is useful as a novel marker of podocyte injury in human glomerulopathy., [RefSeq, PubMed]; The number of dendrin positive nuclei was higher in podocytopathies than in inflammatory glomerular diseases and correlated with chronic tubulointerstitial changes and lower creatinine clearance. Publication Status: Online-Only, [RefSeq, PubMed]; The role of dendrin in IgA nephropathy., [RefSeq, PubMed]; YAP binding to dendrin is a prosurvival mechanism in podocytes., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043204 perikaryon;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "O94850-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0C864-1",
        "uniprot_id": "DANCR_HUMAN",
        "mass": 16785.0,
        "length": 163,
        "protein_name": "Putative uncharacterized protein DANCR",
        "gene_name": "DANCR",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DANCR; ANCR; KIAA0114; SNHG13",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative uncharacterized protein DANCR; Anti-differentiation ncRNA protein; Differentiation antagonizing non-protein coding RNA; Small nucleolar RNA host gene protein 13",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 4,
        "publication_id_list": "11752456;22302877;35051231;38253038",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A024RD90",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "P0C864-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0DP73-1",
        "uniprot_id": "D130B_HUMAN",
        "mass": 8736.0,
        "length": 79,
        "protein_name": "Beta-defensin 130B",
        "gene_name": "DEFB130B",
        "organism": "Human",
        "refseq_name": "beta-defensin 130B precursor",
        "refseq_ac": "NP_001182186",
        "gene_names_uniprotkb": "DEFB130B",
        "gene_names_refseq": "DEFB130B",
        "protein_names_uniprotkb": "Beta-defensin 130B",
        "protein_names_refseq": "beta-defensin 130-like; beta-defensin 130B precursor; beta-defensin 130B; defensin, beta 130-like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100133267);  (hsa:245940);  (R-HSA-1461957);  (R-HSA-1461973)",
        "pathway_count": 4,
        "publication_count": 15,
        "publication_id_list": "10521347;10914484;11085990;11702237;11934878;12949495;18006661;20214904;20385753;20483750;21122132;28181499;31844290;37217939;9541493",
        "class_list": "",
        "function": "Antimicrobial host-defense peptide. Has an antiplasmodial activity., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q30KQ2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "P0DP73-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0DP74-1",
        "uniprot_id": "D130A_HUMAN",
        "mass": 8736.0,
        "length": 79,
        "protein_name": "Beta-defensin 130A",
        "gene_name": "DEFB130A",
        "organism": "Human",
        "refseq_name": "beta-defensin 130A precursor",
        "refseq_ac": "NP_001032893",
        "gene_names_uniprotkb": "DEFB130A; DEFB130; DEFB30",
        "gene_names_refseq": "DEFB-30; DEFB130A; DEFB130L; DEFB130; DEFB30",
        "protein_names_uniprotkb": "Beta-defensin 130A; Beta-defensin 130; Beta-defensin 30; DEFB-30; Defensin, beta 130",
        "protein_names_refseq": "beta-defensin 130A precursor; beta-defensin 130A; beta-defensin 130; beta-defensin 30; defensin beta 130; defensin, beta 30",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100133267);  (hsa:245940);  (R-HSA-1461957);  (R-HSA-1461973)",
        "pathway_count": 4,
        "publication_count": 14,
        "publication_id_list": "10521347;10914484;11085990;11702237;11934878;12949495;16033865;18006661;20214904;20385753;20483750;21122132;28181499;9541493",
        "class_list": "",
        "function": "Antimicrobial host-defense peptide. Has an antiplasmodial activity., [UniProtKB, PubMed]; Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014]., [RefSeq]; The protein encoded by this gene is thought to display antimicrobial activity., [RefSeq, PubMed]; These results suggest that DEFB130 might be one of the macrophage effector molecules for eliminating malarial parasites. Our data broaden our knowledge of the immunological response of macrophages to iRBCs and shed light on a new target for therapeutic intervention. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q30KQ2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "P0DP74-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P17707-1",
        "uniprot_id": "DCAM_HUMAN",
        "mass": 38340.0,
        "length": 334,
        "protein_name": "S-adenosylmethionine decarboxylase proenzyme",
        "gene_name": "AMD1",
        "organism": "Human",
        "refseq_name": "S-adenosylmethionine decarboxylase proenzyme isoform 1",
        "refseq_ac": "NP_001625",
        "gene_names_uniprotkb": "AMD1; AMD",
        "gene_names_refseq": "ADOMETDC; AMD1; AMD; SAMDC",
        "protein_names_uniprotkb": "S-adenosylmethionine decarboxylase proenzyme; 4.1.1.50; AdoMetDC; SAMDC",
        "protein_names_refseq": "S-adenosylmethionine decarboxylase 1; S-adenosylmethionine decarboxylase proenzyme isoform 1; S-adenosylmethionine decarboxylase proenzyme",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); lung non-small cell carcinoma (Disease Ontology:DOID:3908)",
        "pathway": " (hsa:262);  (R-HSA-351202)",
        "pathway_count": 2,
        "publication_count": 61,
        "publication_id_list": "10029540;10378277;10574985;10623504;11237011;11583147;17407445;17585781;18367445;18669648;1917972;2069720;2460457;24714562;24715725;25880248;26154972;2687270;26992070;27600516;27846572;27862975;27920218;28228285;28649982;28834231;28904123;29242379;29557506;30315122;30484775;31217245;31844290;31848261;32157095;32161166;32350084;32357974;32488085;32502341;33141586;33203990;33298915;33392160;33717175;33912179;33936100;34087483;34171305;34185709;34211107;34932366;35051231;35251023;35580925;36010968;36241641;36284347;37938771;38654332;7546290",
        "class_list": "",
        "function": "AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth., [RefSeq, PubMed]; AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis. Publication Status: Online-Only, [RefSeq, PubMed]; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively spliced transcript variants have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. [provided by RefSeq, Dec 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 25,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E1P5F7;Q5VXN4;Q5VXN6;Q9BWK4",
        "ec_number_list": "4.1.1.50",
        "go_molecular_function": "GO:0019810 putrescine binding;GO:0042802 identical protein binding;GO:0004014 adenosylmethionine decarboxylase activity",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0006597 spermine biosynthetic process;GO:0008295 spermidine biosynthetic process;GO:0006595 polyamine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "P17707-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q01524-1",
        "uniprot_id": "DEF6_HUMAN",
        "mass": 10975.0,
        "length": 100,
        "protein_name": "Defensin-6",
        "gene_name": "DEFA6",
        "organism": "Human",
        "refseq_name": "defensin-6 preproprotein",
        "refseq_ac": "NP_001917",
        "gene_names_uniprotkb": "DEFA6; DEF6",
        "gene_names_refseq": "DEF6; DEFA6; HD-6",
        "protein_names_uniprotkb": "Defensin-6; Defensin, alpha 6",
        "protein_names_refseq": "defensin, alpha 6, Paneth cell-specific; defensin-6 preproprotein; defensin-6",
        "tax_id": 9606,
        "disease": "orofacial cleft (Disease Ontology:DOID:0050567); inflammatory bowel disease (Disease Ontology:DOID:0050589); alcohol dependence (Disease Ontology:DOID:0050741); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); medulloblastoma (Disease Ontology:DOID:0050902); myelodysplastic syndrome (Disease Ontology:DOID:0050908); pre-malignant neoplasm (Disease Ontology:DOID:0060071); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); drug allergy (Disease Ontology:DOID:0060500); alcohol-associated liver disease (Disease Ontology:DOID:0070658); mucositis (Disease Ontology:DOID:0080178); colorectal carcinoma (Disease Ontology:DOID:0080199); COVID-19 (Disease Ontology:DOID:0080600); venous insufficiency (Disease Ontology:DOID:10128); osteonecrosis (Disease Ontology:DOID:10159); prostate cancer (Disease Ontology:DOID:10283); lymphoid leukemia (Disease Ontology:DOID:1037); Hirschsprung's disease (Disease Ontology:DOID:10487); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); hypospadias (Disease Ontology:DOID:10892); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); head and neck cancer (Disease Ontology:DOID:11934); optic neuritis (Disease Ontology:DOID:1210); beta thalassemia (Disease Ontology:DOID:12241); neutropenia (Disease Ontology:DOID:1227); aplastic anemia (Disease Ontology:DOID:12449); cardiovascular system disease (Disease Ontology:DOID:1287); lung cancer (Disease Ontology:DOID:1324); Fanconi anemia (Disease Ontology:DOID:13636); exfoliation syndrome (Disease Ontology:DOID:13641); Parkinson's disease (Disease Ontology:DOID:14330); aggressive periodontitis (Disease Ontology:DOID:1474); cystic fibrosis (Disease Ontology:DOID:1485); acute chest syndrome (Disease Ontology:DOID:1584); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); congenital heart disease (Disease Ontology:DOID:1682); ovary epithelial cancer (Disease Ontology:DOID:2152); motor neuron disease (Disease Ontology:DOID:231); colon adenocarcinoma (Disease Ontology:DOID:234); anemia (Disease Ontology:DOID:2355); multiple sclerosis (Disease Ontology:DOID:2377); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); cervix carcinoma (Disease Ontology:DOID:2893); pulmonary tuberculosis (Disease Ontology:DOID:2957); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Lynch syndrome (Disease Ontology:DOID:3883); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); liver disease (Disease Ontology:DOID:409); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); esophagus adenocarcinoma (Disease Ontology:DOID:4914); esophageal cancer (Disease Ontology:DOID:5041); liver cirrhosis (Disease Ontology:DOID:5082); peripheral nervous system disease (Disease Ontology:DOID:574); oral submucous fibrosis (Disease Ontology:DOID:5773); leukopenia (Disease Ontology:DOID:615); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); cataract (Disease Ontology:DOID:83); lung disease (Disease Ontology:DOID:850); Hodgkin's lymphoma (Disease Ontology:DOID:8567); infectious mononucleosis (Disease Ontology:DOID:8568); ulcerative colitis (Disease Ontology:DOID:8577); oral cavity cancer (Disease Ontology:DOID:8618); myeloid leukemia (Disease Ontology:DOID:8692); Crohn's disease (Disease Ontology:DOID:8778); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease Ontology:DOID:9669); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:1671);  (R-HSA-1461973);  (R-HSA-1462054)",
        "pathway_count": 3,
        "publication_count": 34,
        "publication_id_list": "10618521;12021776;12060767;12949495;1302183;1339298;1445872;15210812;1547345;15613481;15616305;17088326;18973303;2006422;20214904;20385753;22722251;2500436;25158166;25354318;2668334;27076903;28026958;29557506;2997278;30808760;30932884;32089753;35562899;7833799;8329717;8417977;8626737;9169779",
        "class_list": "",
        "function": "DEFA6 is associated with overall survival rate of CRC patients and thus an independent prognostic marker for CRC. These results suggest that DEFA6 plays an essential oncogenic role in CRC and serves a good therapeutic target for the disease., [RefSeq, PubMed]; Defensin alpha6 is highly expressed in colon cancer cell lines, [RefSeq, PubMed]; Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel. [provided by RefSeq, Oct 2014]., [RefSeq]; Host-defense peptide that contributes to intestinal innate immunity and mediates homeostasis at mucosal surfaces by forming higher-order oligomers that capture bacteria and prevent microbial invasion of the epithelium (PubMed:15616305, PubMed:17088326, PubMed:25158166, PubMed:25354318, PubMed:28026958). After binding to bacterial surface proteins, undergoes ordered self-assembly to form fibril-like nanonets that surround and entangle bacteria and thereby prevent bacterial invasion across the epithelial barrier (PubMed:22722251). Entangles and agglutinates Gram-negative bacteria, such as E.coli, S.typhimurium and Y.enterocolitica, and Gram-positive bacteria such as L.monocytogenes, thereby protecting the intestine against invasion by enteric bacterial pathogens (PubMed:22722251, PubMed:25158166, PubMed:27076903). Blocks adhesion of C.albicans to intestinal epithelial cells and thereby suppresses fungal invasion of epithelial cells and biofilm formation (PubMed:28026958). Under reducing conditions and in an acidic environment similar to the intestinal milieu, exhibits inhibitory activity against anaerobic bacteria such as B.adolescentis, L.acidophilus and B.breve, as well as B.longum and S.thermophilus, possibly by leading to alterations in bacterial cell envelope structures (PubMed:25354318). The disulfide-linked oxidized form exhibits negligible antimicrobial activity against Gram-negative and Gram-positive bacteria, as compared to the enteric defensin DEFA5 (PubMed:15616305, PubMed:17088326)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Human alpha-Defensin-6 Neutralizes Clostridioides difficile Toxins TcdA and TcdB by Direct Binding. Publication Status: Online-Only, [RefSeq, PubMed]; Study reports that HD6 affords protection against invasion by enteric bacterial pathogens in vitro and in vivo; after stochastic binding to bacterial surface proteins, HD6 undergoes ordered self-assembly to form fibrils and nanonets that surround and entangle bacteria, [RefSeq, PubMed]; Upregulated Expression of Intestinal Antimicrobial Peptide HD5 Associated with Renal Function in IgA Nephropathy. Erratum:[Dis Markers. 2022 Aug 17;2022:9797825. doi: 10.1155/2022/9797825. PMID: 36033832] Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 92,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6EZF9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005796 Golgi lumen;GO:0030133 transport vesicle",
        "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q01524-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q16760-1",
        "uniprot_id": "DGKD_HUMAN",
        "mass": 134525.0,
        "length": 1214,
        "protein_name": "Diacylglycerol kinase delta",
        "gene_name": "DGKD",
        "organism": "Human",
        "refseq_name": "diacylglycerol kinase delta isoform 1",
        "refseq_ac": "NP_003639",
        "gene_names_uniprotkb": "DGKD; KIAA0145",
        "gene_names_refseq": "DGK-delta; DGKD; DGKdelta; dgkd-2",
        "protein_names_uniprotkb": "Diacylglycerol kinase delta; 130 kDa diacylglycerol kinase; 2.7.1.107; DAG kinase delta; DGK-delta; Diglyceride kinase delta",
        "protein_names_refseq": "DAG kinase delta; diacylglycerol kinase delta isoform 1; diacylglycerol kinase, delta 130kDa; diglyceride kinase delta",
        "tax_id": 9606,
        "disease": "Lennox-Gastaut syndrome (Disease Ontology:DOID:0050561); intracranial hypertension (Disease Ontology:DOID:9428)",
        "pathway": " (hsa:8527);  (R-HSA-114508)",
        "pathway_count": 2,
        "publication_count": 63,
        "publication_id_list": "11080611;11237011;11413485;11805119;12084710;12200442;15228384;17880279;19033211;2175712;23949095;25418920;25576301;26154972;26992070;27846572;27920218;28199087;28218747;28446606;28832583;28904123;29242379;29437277;29493099;29557506;29786170;30315122;30379171;30410026;30524438;30833945;31092671;31154438;31844290;31980461;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32897882;32983136;33298915;33592498;33717175;33912179;33968037;33981976;34171305;34357683;34509645;34561969;35051231;35254053;35580925;36010968;36241641;8626538;9601053;9930701",
        "class_list": "",
        "function": "Alternative splicing of the gene generates two isoforms differing in their expression patterns and in regulatory functions, [RefSeq, PubMed]; Diacylglycerol kinase delta and sphingomyelin synthase-related protein functionally interact via their sterile alpha motif domains., [RefSeq, PubMed]; Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Purification and characterization of DGKepsilon's enzymatic and conformational properties, [RefSeq, PubMed]; This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14158;Q6PK55;Q8NG53",
        "ec_number_list": "2.7.1.107;2.7.1.93;2.7.1.94;2.7.1.138",
        "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit",
        "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0046834 lipid phosphorylation;GO:0006654 phosphatidic acid biosynthetic process;GO:0006897 endocytosis;GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 6.8,
        "record_id": "Q16760-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q30KP8-1",
        "uniprot_id": "DB136_HUMAN",
        "mass": 8755.0,
        "length": 78,
        "protein_name": "Defensin beta 136",
        "gene_name": "DEFB136",
        "organism": "Human",
        "refseq_name": "defensin beta 136 precursor",
        "refseq_ac": "NP_001028190",
        "gene_names_uniprotkb": "DEFB136",
        "gene_names_refseq": "DEFB136; DEFB137",
        "protein_names_uniprotkb": "Defensin beta 136; Beta-defensin 136; DEFB137",
        "protein_names_refseq": "beta-defensin 136; beta-defensin 137; defensin beta 136 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:613210);  (R-HSA-1461957);  (R-HSA-1461973)",
        "pathway_count": 3,
        "publication_count": 14,
        "publication_id_list": "10521347;10914484;11085990;11702237;11934878;12949495;16033865;18006661;20214904;20385753;20483750;21122132;34481960;9541493",
        "class_list": "",
        "function": "Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014]., [RefSeq]; Host defense peptide that exhibits antibacterial and antifungal activity (PubMed:34481960). Exhibits antimicrobial activity against E.coli, S.aureus and C.albicans (in vitro) (PubMed:34481960). Has high lipopolysaccharide (LPS)-binding affinity, and may thereby be involved in immunoregulation through LPS neutralization (PubMed:34481960)., [UniProtKB, PubMed]; The protein encoded by this gene is thought to display antimicrobial activity., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4QY36",
        "ec_number_list": "",
        "go_molecular_function": "GO:0001530 lipopolysaccharide binding",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0031640 killing of cells of another organism;GO:0061760 antifungal innate immune response;GO:0140367 antibacterial innate immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q30KP8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q30KQ4-1",
        "uniprot_id": "DB116_HUMAN",
        "mass": 11544.0,
        "length": 102,
        "protein_name": "Beta-defensin 116",
        "gene_name": "DEFB116",
        "organism": "Human",
        "refseq_name": "beta-defensin 116 precursor",
        "refseq_ac": "NP_001032820",
        "gene_names_uniprotkb": "DEFB116; DEFB16",
        "gene_names_refseq": "DEFB-16; DEFB116",
        "protein_names_uniprotkb": "Beta-defensin 116; Beta-defensin 16; DEFB-16; Defensin, beta 116",
        "protein_names_refseq": "beta-defensin 116 precursor; beta-defensin 116; beta-defensin 16; defensin, beta 16",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:245930);  (R-HSA-1461957);  (R-HSA-1461973)",
        "pathway_count": 3,
        "publication_count": 13,
        "publication_id_list": "10521347;10914484;11085990;11702237;11934878;12949495;16033865;18006661;20214904;20385753;20483750;21122132;9541493",
        "class_list": "",
        "function": "Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. [provided by RefSeq, Oct 2014]., [RefSeq]; Has antibacterial activity., [UniProtKB]; The encoded protein is thought to display antimicrobial activity., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0045087 innate immune response;GO:0042742 defense response to bacterium",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q30KQ4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q30KQ5-1",
        "uniprot_id": "DB115_HUMAN",
        "mass": 10071.0,
        "length": 88,
        "protein_name": "Beta-defensin 115",
        "gene_name": "DEFB115",
        "organism": "Human",
        "refseq_name": "beta-defensin 115 precursor",
        "refseq_ac": "NP_001032819",
        "gene_names_uniprotkb": "DEFB115; DEFB15",
        "gene_names_refseq": "DEFB-15; DEFB115",
        "protein_names_uniprotkb": "Beta-defensin 115; Beta-defensin 15; DEFB-15; Defensin, beta 115",
        "protein_names_refseq": "beta-defensin 115 precursor; beta-defensin 115; beta-defensin 15; defensin, beta 15",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:245929);  (R-HSA-1461957);  (R-HSA-1461973)",
        "pathway_count": 3,
        "publication_count": 14,
        "publication_id_list": "10521347;10914484;11085990;11702237;11934878;12949495;16033865;18006661;20214904;20385753;20483750;21122132;23481700;9541493",
        "class_list": "",
        "function": "Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. [provided by RefSeq, Oct 2014]., [RefSeq]; Has antibacterial activity., [UniProtKB]; The encoded protein is thought to display antimicrobial activity., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0140912 membrane destabilizing activity",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0031640 killing of cells of another organism",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q30KQ5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q30KQ9-1",
        "uniprot_id": "DB110_HUMAN",
        "mass": 8001.0,
        "length": 67,
        "protein_name": "Beta-defensin 110",
        "gene_name": "DEFB110",
        "organism": "Human",
        "refseq_name": "beta-defensin 110 isoform a precursor",
        "refseq_ac": "NP_001032586",
        "gene_names_uniprotkb": "DEFB110; DEFB10; DEFB111; DEFB11",
        "gene_names_refseq": "DEFB-10; DEFB-11; DEFB110; DEFB111",
        "protein_names_uniprotkb": "Beta-defensin 110; Beta-defensin 10; Beta-defensin 111; Beta-defensin 11; DEFB-10; DEFB-11; Defensin, beta 110; Defensin, beta 111",
        "protein_names_refseq": "beta-defensin 10; beta-defensin 110 isoform a precursor; beta-defensin 110; beta-defensin 111; defensin, beta 10; defensin, beta 110 locus",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:245913);  (R-HSA-1461957);  (R-HSA-1461973)",
        "pathway_count": 3,
        "publication_count": 14,
        "publication_id_list": "10521347;10914484;11085990;11702237;11934878;12949495;16033865;18006661;20214904;20385753;20483750;21122132;31325337;9541493",
        "class_list": "",
        "function": "Antimicrobial activity and structure of a consensus human beta-defensin and its comparison to a novel putative hBD10., [RefSeq, PubMed]; Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]., [RefSeq]; Has antibacterial activity., [UniProtKB]; The encoded protein is thought to have antimicrobial activity., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q30KR0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0045087 innate immune response;GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q30KQ9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q30KR1-1",
        "uniprot_id": "DB109_HUMAN",
        "mass": 9886.0,
        "length": 87,
        "protein_name": "Beta-defensin 109B",
        "gene_name": "DEFB109B",
        "organism": "Human",
        "refseq_name": "beta-defensin 109B precursor",
        "refseq_ac": "NP_001032457",
        "gene_names_uniprotkb": "DEFB109B; DEFB109P1B",
        "gene_names_refseq": "DEF109P1B; DEFB-109; DEFB109B; DEFB109P1B; DEFB109; HBD9",
        "protein_names_uniprotkb": "Beta-defensin 109B; DEFB-109; Defensin beta 109B; HBD9",
        "protein_names_refseq": "beta-defensin 109B precursor; beta-defensin 109B; defensin beta 109 pseudogene 1B; defensin, beta 9 pseudogene; putative beta-defensin 109B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:641517);  (R-HSA-1461957)",
        "pathway_count": 2,
        "publication_count": 15,
        "publication_id_list": "10521347;10914484;11085990;11702237;11934878;16033865;18006661;18172071;20375350;20483750;21122132;27862975;29557506;35051231;9541493",
        "class_list": "",
        "function": "Has antibacterial activity., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region",
        "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q30KR1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q3SXM0-1",
        "uniprot_id": "DC4L1_HUMAN",
        "mass": 44264.0,
        "length": 396,
        "protein_name": "DDB1- and CUL4-associated factor 4-like protein 1",
        "gene_name": "DCAF4L1",
        "organism": "Human",
        "refseq_name": "DDB1- and CUL4-associated factor 4-like protein 1",
        "refseq_ac": "NP_001025126",
        "gene_names_uniprotkb": "DCAF4L1; WDR21B",
        "gene_names_refseq": "DCAF4L1; WDR21B",
        "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 4-like protein 1; WD repeat-containing protein 21B",
        "protein_names_refseq": "DDB1- and CUL4-associated factor 4-like protein 1; WD repeat domain 21B; WD repeat-containing protein 21B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:285429)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "24715725;26154972;27600516;27920218;28832583;28834231;29242379;29557506;30315122;30524438;31154438;31429579;31844290;32387766;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KVI3;Q3ZCW8;Q499Y5;Q9UFI0",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0080008 Cul4-RING E3 ubiquitin ligase complex",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q3SXM0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q58WW2-1",
        "uniprot_id": "DCAF6_HUMAN",
        "mass": 96292.0,
        "length": 860,
        "protein_name": "DDB1- and CUL4-associated factor 6",
        "gene_name": "DCAF6",
        "organism": "Human",
        "refseq_name": "DDB1- and CUL4-associated factor 6 isoform b",
        "refseq_ac": "NP_001017977",
        "gene_names_uniprotkb": "DCAF6; IQWD1; MSTP055",
        "gene_names_refseq": "1200006M05Rik; ARCAP; DCAF6; IQWD1; MSTP055; NRIP; PC326",
        "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 6; ARCAP; Androgen receptor complex-associated protein; IQ motif and WD repeat-containing protein 1; NRIP; Nuclear receptor interaction protein",
        "protein_names_refseq": "DDB1- and CUL4-associated factor 6 isoform b; IQ motif and WD repeat-containing protein 1; IQ motif and WD repeats 1; androgen receptor complex-associated protein; nuclear receptor interaction protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55827);  (R-HSA-8951664)",
        "pathway_count": 2,
        "publication_count": 165,
        "publication_id_list": "10535940;10597293;10811609;10878807;10973499;11069780;11230166;11237011;11259415;11292861;11292862;11454738;11585840;11733065;11961546;12101228;12186903;12504025;12504026;12526791;12538644;12609982;12682069;12759363;12816948;14690597;14757770;15282312;15361859;15367669;15537541;15572695;15574592;15601839;15652483;15688063;15694336;15784617;15799966;16171779;16401342;16547496;16647857;16707496;16790436;16943200;16949367;16964240;17081101;17081983;17132228;17183367;17220875;17332328;17497243;17785452;17984071;18093314;18206966;18452278;18669648;18673574;18767875;18775313;18776931;18805092;18826954;18851830;18926707;19250909;19321346;19415658;19617556;19651622;19690332;19748355;20068231;21447816;21463634;21778237;21863050;21940857;22306028;22466964;22537386;22959436;23186163;23201271;23333871;23401859;23453757;23481700;23535662;23535663;23563313;23583660;23912815;23986495;24076655;24275569;24366543;24366607;24636985;24714562;24793695;24793696;25314029;25349211;25355947;25505266;25531226;25576301;26344709;26460955;26632597;26768311;26811146;26906416;26992070;27030794;27222660;27565346;27846572;27920218;28063628;28115426;28832583;28904123;29153394;29242379;29393594;29437277;29508533;29557506;29632046;29786170;30410026;30429286;30610225;31217245;31844290;31848261;32005965;32157095;32284348;32387766;32488085;32502341;32938616;33298915;33444648;33592498;33773096;33968037;33981976;34932366;35051231;35580925;36241641;36688959;38163571;38253038;9790970;9887101;9891082",
        "class_list": "",
        "function": "A survey results showed that ten cancer cases were revealed to express the NRIP in six malignancies, but not all of these specific tumor types consistently showed positive NRIP expression. Publication Status: Online-Only, [RefSeq, PubMed]; Autoantibody of NRIP, a novel AChR-interacting protein, plays a detrimental role in myasthenia gravis., [RefSeq, PubMed]; Identification of circular RNA-Dcaf6 as a therapeutic target for optic nerve crush-induced RGC degeneration., [RefSeq, PubMed]; Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex., [UniProtKB, PubMed, PubMed, PubMed]; NRIP interacts with either androgen or glucocorticoid receptors, [RefSeq, PubMed]; NRIP plays a feed-forward role enhancing androgen receptor (AR)-driven NRIP promoter activity via NRIP forming a complex with AR to protect AR protein from proteasome degradation., [RefSeq, PubMed]; The CRL4[DCAF6] E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration., [RefSeq, PubMed]; The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression. [provided by RefSeq, Mar 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A295;B4DNB8;Q7L8I0;Q8IXH3;Q8TB19",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0080008 Cul4-RING E3 ubiquitin ligase complex",
        "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 16.8,
        "record_id": "Q58WW2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5H9U9-1",
        "uniprot_id": "DDX6L_HUMAN",
        "mass": 197614.0,
        "length": 1706,
        "protein_name": "Probable ATP-dependent RNA helicase DDX60-like",
        "gene_name": "DDX60L",
        "organism": "Human",
        "refseq_name": "probable ATP-dependent RNA helicase DDX60-like isoform 1",
        "refseq_ac": "NP_001012985",
        "gene_names_uniprotkb": "DDX60L",
        "gene_names_refseq": "DDX60L",
        "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX60-like; 3.6.4.13; DEAD box protein 60-like",
        "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like; DEAD box protein 60-like; DEAD-box helicase 60 like; probable ATP-dependent RNA helicase DDX60-like isoform 1; probable ATP-dependent RNA helicase DDX60-like; putative ATP-dependent RNA helicase DDX60",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91351)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;23481700;25645385;25892735;26269178;26375851;32938616;33691108;34087483;34789165;35051231;36010968;37938771;39531497",
        "class_list": "",
        "function": "DDX60L is an interferon-gamma stimulated gene product restricting Hepatitis C virus replication in cell culture., [RefSeq, PubMed]; Identification and functional analysis of novel oncogene DDX60L in pancreatic ductal adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the DExD/H-box helicase family of proteins, a subset of the super family 2 helicases. Members of the DExD/H-box helicase family share a conserved functional core comprised of two RecA-like globular domains. These domains contain conserved motifs that mediate ATP binding, ATP hydrolysis, nucleic acid binding, and RNA unwinding. In addition to functions in RNA metabolism, members of this family are involved in anti-viral immunity and act as cytosolic sensors of viral nucleic acids. The protein encoded by this gene has been shown to inhibit hepatitis C virus replication in response to interferon stimulation in cell culture. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 34,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A804HKC9;Q96ND6",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003725 double-stranded RNA binding;GO:0003727 single-stranded RNA binding;GO:0003724 RNA helicase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0051607 defense response to virus",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q5H9U9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5J5C9-1",
        "uniprot_id": "DB121_HUMAN",
        "mass": 8456.0,
        "length": 76,
        "protein_name": "Beta-defensin 121",
        "gene_name": "DEFB121",
        "organism": "Human",
        "refseq_name": "beta-defensin 121 isoform 1 precursor",
        "refseq_ac": "NP_001011878",
        "gene_names_uniprotkb": "DEFB121; DEFB21",
        "gene_names_refseq": "DEFB121; DEFB21; ESC42RELC",
        "protein_names_uniprotkb": "Beta-defensin 121; Beta-defensin 21; DEFB-21; Defensin, beta 121",
        "protein_names_refseq": "beta-defensin 121 isoform 1 precursor; beta-defensin 121; beta-defensin 21; defensin, beta 21; epididymis secretory sperm binding protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:245934);  (R-HSA-1461957);  (R-HSA-1461973)",
        "pathway_count": 3,
        "publication_count": 13,
        "publication_id_list": "10521347;10914484;11085990;11702237;11934878;12949495;15772680;18006661;20214904;20385753;20483750;21122132;9541493",
        "class_list": "",
        "function": "Has antibacterial activity., [UniProtKB]; This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]., [RefSeq]; This gene is thought to encode a peptide that displays antimicrobial activity., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L4N1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0140912 membrane destabilizing activity",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0031640 killing of cells of another organism",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q5J5C9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5SW24-1",
        "uniprot_id": "DACT2_HUMAN",
        "mass": 82700.0,
        "length": 774,
        "protein_name": "Dapper homolog 2",
        "gene_name": "DACT2",
        "organism": "Human",
        "refseq_name": "dapper homolog 2 isoform b",
        "refseq_ac": "NP_001273279",
        "gene_names_uniprotkb": "DACT2; C6orf116; PP13671",
        "gene_names_refseq": "C6orf116; DACT2; DAPPER2; DPR2; bA503C24.7",
        "protein_names_uniprotkb": "Dapper homolog 2; Dapper antagonist of catenin 2",
        "protein_names_refseq": "dapper antagonist of catenin 2; dapper homolog 2 isoform b; dapper homolog 2, antagonist of beta-catenin; dapper, antagonist of beta-catenin, homolog 2",
        "tax_id": 9606,
        "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584); bile duct carcinoma (Disease Ontology:DOID:4897); pancreatic carcinoma (Disease Ontology:DOID:4905)",
        "pathway": " (hsa:168002)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "15498874;18370954;20877624;22806826;23244112;23481700;28832583;29242379;29393594;30075814;30359298;30429286;31844290;31998317;32454406;34171305;35051231;37610179",
        "class_list": "",
        "function": "Comparative exome sequencing reveals novel candidate genes for retinitis pigmentosa. Erratum:[EBioMedicine. 2022 Mar;77:103913. doi: 10.1016/j.ebiom.2022.103913. PMID: 35248995], [RefSeq, PubMed]; Different expression of DACT1, DACT2, and CYCLIN D1 genes in human colorectal cancer tissues and its association with clinicopathological characteristics., [RefSeq, PubMed]; Epigenetic regulation of DACT2 is a key component of the Wnt signalling pathway in human lung cancer., [RefSeq, PubMed]; Hypermethylation of Dact1 gene is associated with transitional cell carcinomas., [RefSeq, PubMed]; Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity)., [UniProtKB]; Nuclear beta-catenin was more frequently expressed in non-polypoid growth low grade colorectal neoplasms than in polypoid growth neoplasms., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Results demonstrate that DACT2 is frequently inactivated epigenetically by CpG methylation in nasopharyngeal carcinoma (NPC), while it inhibits NPC cell proliferation and metastasis via suppressing beta-catenin/Cdc25c signaling. These findings suggest that DACT2 promoter methylation is a potential epigenetic biomarker for the detection of NPC. Publication Status: Online-Only, [RefSeq, PubMed]; Studies suggested that DACT2 expression in nasopharyngeal carcinoma cells is restored by TET1 which demethylates its promotor region. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2NKJ2;Q569G0;Q8WYW2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005080 protein kinase C binding;GO:0008134 transcription factor binding;GO:0008013 beta-catenin binding;GO:0051018 protein kinase A binding;GO:0070097 delta-catenin binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:1900108 negative regulation of nodal signaling pathway;GO:0007162 negative regulation of cell adhesion;GO:0043588 skin development;GO:0072061 inner medullary collecting duct development;GO:0003382 epithelial cell morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q5SW24-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5T197-1",
        "uniprot_id": "DCST1_HUMAN",
        "mass": 80712.0,
        "length": 706,
        "protein_name": "E3 ubiquitin-protein ligase DCST1",
        "gene_name": "DCST1",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase DCST1 isoform 2",
        "refseq_ac": "NP_001137159",
        "gene_names_uniprotkb": "DCST1",
        "gene_names_refseq": "DCST1; SNKY; SPE49",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase DCST1; 2.3.2.27; DC-STAMP domain-containing protein 1; RING-type E3 ubiquitin transferase",
        "protein_names_refseq": "DC-STAMP domain-containing protein 1; E3 ubiquitin-protein ligase DCST1 isoform 2; E3 ubiquitin-protein ligase DCST1; RING-type E3 ubiquitin transferase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:149095)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11237011;27782195;31844290;32418155;32556010;33533513;35051231;37074911",
        "class_list": "",
        "function": "DCST1 regulated Type I interferon signaling by interacting with and promoting ubiquitination-mediated degradation of STAT2, an essential component of antiviral gene induction. Publication Status: Online-Only, [RefSeq, PubMed]; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteasomal degradation thereby negatively regulating type-I-interferon signaling. Essential sperm cell-surface protein required for sperm-egg fusion and fertilization (By similarity)., [UniProtKB, PubMed, UniProtKB]; LncRNA DCST1-AS1 downregulates miR-29b through methylation in glioblastoma (GBM) to promote cancer cell proliferation., [RefSeq, PubMed]; LncRNA DCST1-AS1 inhibits PDLCs' proliferation in periodontitis and may bind with miR-21 precursor to upregulate PLAP-1., [RefSeq, PubMed]; TACE and DC-STAMP protein levels are elevated in patients with periodontitis, favoring progression of bone resorption., [RefSeq, PubMed]; This gene encodes a protein with a domain similar to one found in dendritic cells (PMID:11169400) which play a key role in antigen processing and display for immune responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 9641,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DXA0;E9PHV3;Q5T198;Q6P1W6;Q71S70;Q96M70",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0002080 acrosomal membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0045087 innate immune response;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q5T197-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5T1A1-1",
        "uniprot_id": "DCST2_HUMAN",
        "mass": 86230.0,
        "length": 773,
        "protein_name": "DC-STAMP domain-containing protein 2",
        "gene_name": "DCST2",
        "organism": "Human",
        "refseq_name": "DC-STAMP domain-containing protein 2",
        "refseq_ac": "NP_653223",
        "gene_names_uniprotkb": "DCST2",
        "gene_names_refseq": "DCST2; SPE42",
        "protein_names_uniprotkb": "DC-STAMP domain-containing protein 2",
        "protein_names_refseq": "DC-STAMP domain-containing protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:127579)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "11237011;18952287;24715725;25281659;29557506;30484775;30524438;31154438;32350084;33968037;35051231;39531497",
        "class_list": "",
        "function": "Essential sperm cell-surface protein required for sperm-egg fusion and fertilization., [UniProtKB, UniProtKB]; OS9 is critically involved in the modulation of ER-to-Golgi transport of DC-STAMP in response to TLR triggering, suggesting a novel role for OS9 in myeloid differentiation and cell fusion., [RefSeq, PubMed]; This study highlights that common variation in DCST2 influences variation in early growth and adult height., [RefSeq, PubMed]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2M2R2;Q8N810;Q96M03",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0002080 acrosomal membrane",
        "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q5T1A1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6P3S1-1",
        "uniprot_id": "DEN1B_HUMAN",
        "mass": 86552.0,
        "length": 775,
        "protein_name": "DENN domain-containing protein 1B",
        "gene_name": "DENND1B",
        "organism": "Human",
        "refseq_name": "DENN domain-containing protein 1B isoform 3",
        "refseq_ac": "NP_001182144",
        "gene_names_uniprotkb": "DENND1B; C1orf218; FAM31B",
        "gene_names_refseq": "C1ORF18; C1orf218; DENND1B; FAM31B",
        "protein_names_uniprotkb": "DENN domain-containing protein 1B; Connecdenn 2; Protein FAM31B",
        "protein_names_refseq": "DENN domain-containing protein 1B isoform 3; DENN domain-containing protein 1B; DENN/MADD domain containing 1B; connecdenn 2; family with sequence similarity 31, member B",
        "tax_id": 9606,
        "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); asthma (Disease Ontology:DOID:2841); intrinsic asthma (Disease Ontology:DOID:9360); allergic asthma (Disease Ontology:DOID:9415)",
        "pathway": " (hsa:163486);  (R-HSA-8876198)",
        "pathway_count": 2,
        "publication_count": 222,
        "publication_id_list": "10818110;10990452;11038176;11179213;11237011;11516400;11689439;11703925;11746448;11784320;11917121;12058051;12221131;12244319;12364329;12427552;12475894;12684051;12944476;12972505;15096524;15138286;1516130;15247254;15388334;15528189;15561770;15592455;15692570;15878329;15914536;15958533;16207721;16373702;16410077;16525024;16525121;16571673;16641372;16754960;16880209;16950109;17043139;17132146;17189207;17208202;17239822;17287728;17488286;17562788;17574030;17646400;17671165;17678623;18076383;18094055;18354496;18367545;1845915;18477474;18559336;18585354;18664496;18701652;18779367;18804435;1900457;19109890;19345684;19403694;19490898;19620288;19656848;19690332;19725050;19729655;19745841;20008558;20032318;20154091;20159109;20159556;20305638;20308558;20404108;20434987;20592283;20797862;20851765;20937701;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21951725;22013193;22065758;22072793;22171327;22365832;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23645161;23678941;23684622;23713133;23839779;24296415;24520163;24644286;24694596;24719330;24891604;24917561;24967941;25074980;25341920;25343031;25472813;25576301;25645385;25648148;25713415;25925668;26055712;26177209;26245486;26434594;26538022;26774822;26925400;26936971;26992070;27041585;27044746;27103185;27246931;27329675;27600516;28668455;28832583;28834231;29242379;29557506;29632046;29786170;30429286;30779550;31154438;31222486;31608842;31844290;31848261;32157095;32265295;32357974;32387766;32938616;32983136;33537174;33592498;33968037;33981976;34185709;35051231;35318648;35580925;36010968;36215666;36241641;7688123;7911226;8144603;8408203;8522602;8863739;9020086;9020161;9030515;9136770;9323142;9590177;9733780",
        "class_list": "",
        "function": "Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]., [RefSeq]; Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Polymorphisms in the DENND1B are significantly associated with development of asthma and atopy and these polymorphisms can influence DENND1B expression and consequently, asthma., [RefSeq, PubMed]; Study reveals a previously unrecognized mechanism by which DENND1B regulates surface TCR dynamics to fine-tune TH2 cell signaling and effector functions. Dennd1b-/- TH2 cells exhibit delayed TCR downmodulation following TCR activation that is associated with enhanced TCR signaling and greater transcriptional activation and secretion of TH2-associated cytokines., [RefSeq, PubMed]; The guanine nucleotide exchange factor activity of connecdenn 1 and 2 are autoinhibited, and this is regulated by Akt activation downstream of insulin stimulation., [RefSeq, PubMed]; Variation at DENND1B and Asthma on the Island of Tristan da Cunha., [RefSeq, PubMed]; We have identified a locus containing DENND1B on chromosome 1q31.3 that is associated with susceptibility to asthma. Erratum:[N Engl J Med. 2010 Sep 2;363(10):994], [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5MD89;D3PFD5;Q5T3B8;Q5T3B9;Q5T3C1;Q5TAI8;Q6B0I8;Q8NDT1;Q8TBE6;Q9H774;Q9NXU2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:1901981 phosphatidylinositol phosphate binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0030136 clathrin-coated vesicle",
        "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0050852 T cell receptor signaling pathway;GO:0050776 regulation of immune response;GO:0032456 endocytic recycling",
        "synthesized_glycan_count": 0,
        "hit_score": 22.3,
        "record_id": "Q6P3S1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6PH85-1",
        "uniprot_id": "DCNL2_HUMAN",
        "mass": 30179.0,
        "length": 259,
        "protein_name": "DCN1-like protein 2",
        "gene_name": "DCUN1D2",
        "organism": "Human",
        "refseq_name": "DCN1-like protein 2",
        "refseq_ac": "NP_001014305",
        "gene_names_uniprotkb": "DCUN1D2; C13orf17; DCUN1L2",
        "gene_names_refseq": "C13orf17; DCNL2; DCUN1D2",
        "protein_names_uniprotkb": "DCN1-like protein 2; DCNL2; DCUN1 domain-containing protein 2; Defective in cullin neddylation protein 1-like protein 2",
        "protein_names_refseq": "DCN1, defective in cullin neddylation 1, domain containing 2; DCN1-like protein 2; DCUN1 domain-containing protein 2; defective in cullin neddylation protein 1-like protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55208);  (R-HSA-8951664)",
        "pathway_count": 2,
        "publication_count": 114,
        "publication_id_list": "10535940;10597293;10811609;10878807;10973499;11069780;11237011;11259415;11292861;11292862;11454738;11585840;11733065;11961546;12101228;12186903;12504025;12504026;12526791;12538644;12609982;12682069;12759363;12816948;14690597;14757770;15282312;15361859;15367669;15537541;15572695;15574592;15601839;15652483;15688063;15694336;15799966;16171779;16401342;16547496;16647857;16707496;16790436;16943200;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18093314;18206966;18775313;18776931;18805092;18826954;18851830;18926707;19250909;19321346;19617556;19748355;21447816;21463634;21778237;21863050;21940857;22306028;22466964;22537386;22959436;23201271;23333871;23401859;23453757;23535662;23535663;23563313;23583660;23912815;23986495;24076655;24366543;24636985;24715725;24793695;24793696;25314029;25349211;25355947;25531226;26344709;26460955;26632597;26906416;26992070;27030794;27222660;27565346;28115426;29153394;30610225;31844290;32005965;32157095;32284348;32387766;33444648;33968037;36010968;9790970;9887101;9891082",
        "class_list": "",
        "function": "Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and plays an essential role in the regulation of SCF (SKP1-CUL1-F-box protein)-type complexes activity., [UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5JSA5;Q5JSA6;Q5JSA7;Q9NVJ1;Q9NXR6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0032182 ubiquitin-like protein binding;GO:0097602 cullin family protein binding;GO:0031624 ubiquitin conjugating enzyme binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex",
        "go_biological_process": "GO:0045116 protein neddylation;GO:2000436 positive regulation of protein neddylation;GO:2000434 regulation of protein neddylation",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "Q6PH85-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6PJP8-1",
        "uniprot_id": "DCR1A_HUMAN",
        "mass": 116400.0,
        "length": 1040,
        "protein_name": "DNA cross-link repair 1A protein",
        "gene_name": "DCLRE1A",
        "organism": "Human",
        "refseq_name": "DNA cross-link repair 1A protein",
        "refseq_ac": "NP_001258745",
        "gene_names_uniprotkb": "DCLRE1A; KIAA0086; SNM1A; SNM1",
        "gene_names_refseq": "DCLRE1A; PSO2; SNM1A; SNM1",
        "protein_names_uniprotkb": "DNA cross-link repair 1A protein; 3.5.2.6; Beta-lactamase DCLRE1A; SNM1 homolog A; hSNM1A; hSNM1",
        "protein_names_refseq": "DNA cross-link repair 1A protein; DNA-crosslink repair gene SNM1; SNM1 homolog A; beta-lactamase DCLRE1A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9937);  (R-HSA-6783310)",
        "pathway_count": 2,
        "publication_count": 93,
        "publication_id_list": "10848582;11239454;12446782;12509242;15542852;15572677;16916645;16943440;17289582;17412408;17460694;17938197;18082604;18174376;18931676;19111657;19561358;19589784;19596236;19995904;20102227;20347428;20347429;20385554;20603015;20603016;20603073;20670894;20671156;21464321;21701511;21764741;22258451;22287633;22396592;22510687;22692201;23325218;23698467;23723247;24076221;24366607;24389026;24623813;24726325;24905007;25430771;25500724;25645385;25755297;26154972;26992070;27600516;27920218;28218747;28832583;28834231;28904123;29242379;29437277;29493099;29557506;29632046;30315122;30410026;30429286;31154438;31217245;31434986;31844290;31998317;32157095;32265295;32357974;32387766;32488085;32866775;32897882;32938616;33043033;33298915;33592498;33912179;33968037;34185709;34387696;34509645;35051231;35561310;35580925;37938771;38918391;39894887",
        "class_list": "",
        "function": "May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986)., [UniProtKB, PubMed]; Results suggest that 53BP1 and Snm1 may cooperate in the cellular response to genotoxic damage., [RefSeq, PubMed]; SNM1A is crucial for efficient repair of complex DNA breaks in human cells. Publication Status: Online-Only, [RefSeq, PubMed]; Snm1 and 53BP1 are components of a mitotic stress checkpoint that negatively targets the APC prior to chromosome condensation, [RefSeq, PubMed]; Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition., [RefSeq, PubMed]; The SNM1A DNA repair nuclease. Review article, [RefSeq, PubMed]; This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DRC1;Q14701;Q6P5Y3;Q6PKL4",
        "ec_number_list": "3.4.19.12;3.4.13.19;3.5.2.6;3.1.2.2;3.6.4.13;3.1.-.-;3.1.22.-;2.3.2.27;3.1.21.-;3.1.4.1",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0035312 5'-3' DNA exonuclease activity;GO:0008800 beta-lactamase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0051301 cell division;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0036297 interstrand cross-link repair",
        "synthesized_glycan_count": 0,
        "hit_score": 9.6,
        "record_id": "Q6PJP8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q717R9-1",
        "uniprot_id": "CYS1_HUMAN",
        "mass": 16393.0,
        "length": 158,
        "protein_name": "Cystin-1",
        "gene_name": "CYS1",
        "organism": "Human",
        "refseq_name": "cystin-1",
        "refseq_ac": "NP_001032237",
        "gene_names_uniprotkb": "CYS1",
        "gene_names_refseq": "CYS1",
        "protein_names_uniprotkb": "Cystin-1; Cilia-associated protein",
        "protein_names_refseq": "cilia-associated protein; cystin-1",
        "tax_id": 9606,
        "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); stomach cancer (Disease Ontology:DOID:10534)",
        "pathway": " (hsa:192668);  (R-HSA-5624138)",
        "pathway_count": 2,
        "publication_count": 14,
        "publication_id_list": "11854326;12733055;16472755;16525022;18376416;18588884;19850956;20106869;21285245;22085962;22389062;22884633;22960633;34521872",
        "class_list": "",
        "function": "Cystin genetic variants cause autosomal recessive polycystic kidney disease associated with altered Myc expression. Publication Status: Online-Only, [RefSeq, PubMed]; Genomic region comprises three coding exons, which span 22 kb and the transcript harbors an open reading frame of 477 nucleotides encoding a protein with 158 amino acid residues, which is called cystin, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005929 cilium;GO:0005930 axoneme;GO:0060170 ciliary membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q717R9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z7B8-1",
        "uniprot_id": "DB128_HUMAN",
        "mass": 10650.0,
        "length": 93,
        "protein_name": "Beta-defensin 128",
        "gene_name": "DEFB128",
        "organism": "Human",
        "refseq_name": "beta-defensin 128 precursor",
        "refseq_ac": "NP_001032821",
        "gene_names_uniprotkb": "DEFB128; DEFB28",
        "gene_names_refseq": "DEFB-28; DEFB128; DEFB28; hBD-28",
        "protein_names_uniprotkb": "Beta-defensin 128; Beta-defensin 28; DEFB-28; Defensin, beta 128",
        "protein_names_refseq": "beta-defensin 128 precursor; beta-defensin 128; beta-defensin 28; defensin, beta 28",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:245939);  (R-HSA-1461957);  (R-HSA-1461973)",
        "pathway_count": 3,
        "publication_count": 16,
        "publication_id_list": "10521347;10914484;11085990;11702237;11934878;12620395;12949495;18006661;20214904;20385753;20483750;21122132;23481700;24715725;28627688;9541493",
        "class_list": "",
        "function": "Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014]., [RefSeq]; Has antibacterial activity., [UniProtKB]; The protein encoded by this gene is thought to display antimicrobial activity., [RefSeq, PubMed]; This aim of this study was to identify novel biomarkers using comparative global proteome analysis to improve the risk assessment for recurrent coronary events. Beta -defensin-128 and histatin-3 may be potential biomarkers whch may be used to improve risk the stratification for recurrent coronary events., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RU29",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0031640 killing of cells of another organism",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q7Z7B8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86SG3-1",
        "uniprot_id": "DAZ4_HUMAN",
        "mass": 64785.0,
        "length": 579,
        "protein_name": "Deleted in azoospermia protein 4",
        "gene_name": "DAZ4",
        "organism": "Human",
        "refseq_name": "deleted in azoospermia protein 4 isoform 1",
        "refseq_ac": "NP_001005375",
        "gene_names_uniprotkb": "DAZ4",
        "gene_names_refseq": "DAZ4; pDP1680; pDP1681",
        "protein_names_uniprotkb": "Deleted in azoospermia protein 4",
        "protein_names_refseq": "deleted in azoospermia protein 4 isoform 1; deleted in azoospermia protein 4",
        "tax_id": 9606,
        "disease": "Y-linked spermatogenic failure 2 (Disease Ontology:DOID:0070187)",
        "pathway": " (hsa:57135)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "10857750;10903443;10936047;11058556;11095434;11237011;11390979;12511597;12752250;12801575;16275261;18385127;19223287;24878370;26232607;27457284;31429579;35051231",
        "class_list": "",
        "function": "All four DAZ genes are expressed in the human testis, and their products are highly polymorphic among men, [RefSeq, PubMed]; Oligospermia seems to be promoted by removing DAZ4 copy. Deletion of DAZ2 and DAZ4 gene copies is associated with male infertility., [RefSeq, PubMed]; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation., [UniProtKB]; Studies indicate that partial RNA-binding proteins DAZ1/2 deletion was associated wih male infertility, but partial RNA-binding proteins DAZ3/4 deletion was not associated with male infertility. Review article, [RefSeq, PubMed]; Study reported a new type of AZFc deletion (gr/gr-DAZ2-DAZ4-CDY1b) and hypothesis that this new deletion is the result of 2 successive events favored by the unstable structure of AZFc region; also demonstrated that this deletion constitutes a relative high-risk factor for male infertility in Tunisian population, [RefSeq, PubMed]; This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9NR88;Q9NR89",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008494 translation activator activity;GO:0003730 mRNA 3'-UTR binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0070935 3'-UTR-mediated mRNA stabilization;GO:0045948 positive regulation of translational initiation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q86SG3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86XP1-1",
        "uniprot_id": "DGKH_HUMAN",
        "mass": 134866.0,
        "length": 1220,
        "protein_name": "Diacylglycerol kinase eta",
        "gene_name": "DGKH",
        "organism": "Human",
        "refseq_name": "diacylglycerol kinase eta isoform 1",
        "refseq_ac": "NP_001191433",
        "gene_names_uniprotkb": "DGKH",
        "gene_names_refseq": "DGKH; DGKeta",
        "protein_names_uniprotkb": "Diacylglycerol kinase eta; 2.7.1.107; DAG kinase eta; DGK-eta; Diglyceride kinase eta",
        "protein_names_refseq": "DAG kinase eta; diacylglycerol kinase eta isoform 1; diglyceride kinase eta",
        "tax_id": 9606,
        "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)",
        "pathway": " (hsa:160851);  (R-HSA-114508)",
        "pathway_count": 2,
        "publication_count": 56,
        "publication_id_list": "11080611;11237011;11413485;11805119;12810723;17486107;19033211;19478689;19710016;20068231;2175712;23481700;23949095;25505266;25576301;25880248;25892735;26154972;26992070;27255576;28228285;28832583;28855257;28904123;29242379;29493099;29557506;29769354;29936393;30315122;30484775;31092671;31217245;31844290;31848261;32157095;32350084;32357974;32387766;32938616;32983136;33141586;33298915;33592498;33912179;33968037;34087483;34293268;34509645;34932366;35051231;36010968;36215666;36241641;9601053;9930701",
        "class_list": "",
        "function": "Alternative splicing of the human DGK eta gene generates at least two isoforms with distinct biochemical and cell biological properties responding to different cellular metabolic requirements, [RefSeq, PubMed]; DGKeta acts as a novel critical regulatory component of the Ras/B-Raf/C-Raf/MEK/ERK signaling cascade via a previously unidentified mechanism., [RefSeq, PubMed]; Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling., [RefSeq, PubMed]; Diacylglycerol kinase eta (DGKH) is association in the etiology of bipolar disorder. GeneRIF: Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (PubMed:12810723, PubMed:23949095). Plays a key role in promoting cell growth (PubMed:19710016). Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF (PubMed:19710016). Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (PubMed:19710016)., [UniProtKB, PubMed, PubMed, PubMed]; No significant association after multiple-testing correction between any of the single nucleotide polymorphisms in DGKH and bipolar disorder, was found. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Several single variants and genes showed strong association with Panic Disorders, where DGKH was found to be the strongest Panic Disorder associated gene. Interestingly DGKH has previously demonstrated genome-wide significant association with bipolar disorder as well as evidence of association to other mental disorders., [RefSeq, PubMed]; The present study shows that a bipolar-risk allele of DGKH is associated with higher openness to experience, providing further evidence for the implication of this gene in the etiology of bipolar disorder., [RefSeq, PubMed]; This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family. Members of this family are involved in regulating intracellular concentrations of diacylglycerol and phosphatidic acid. Variation in this gene has been associated with bipolar disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A2W7;A6NFX7;B4DZ34;Q5VZW0;Q6PI56;Q86XP2;Q8N3N0;Q8N7J9",
        "ec_number_list": "2.7.1.107;2.7.1.93;2.7.1.94;2.7.1.138",
        "go_molecular_function": "GO:0032093 SAM domain binding;GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0046473 phosphatidic acid metabolic process;GO:0046834 lipid phosphorylation;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 5.7,
        "record_id": "Q86XP1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86XP3-1",
        "uniprot_id": "DDX42_HUMAN",
        "mass": 102975.0,
        "length": 938,
        "protein_name": "ATP-dependent RNA helicase DDX42",
        "gene_name": "DDX42",
        "organism": "Human",
        "refseq_name": "ATP-dependent RNA helicase DDX42",
        "refseq_ac": "NP_031398",
        "gene_names_uniprotkb": "DDX42",
        "gene_names_refseq": "DDX42P; DDX42; RHELP; RNAHP; SF3B8; SF3b125",
        "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX42; 3.6.4.13; DEAD box protein 42; RHELP; RNA helicase-like protein; RNA helicase-related protein; RNAHP; SF3b DEAD box protein; SF3b125; Splicing factor 3B-associated 125 kDa protein",
        "protein_names_refseq": "ATP-dependent RNA helicase DDX42; DEAD (Asp-Glu-Ala-Asp) box helicase 42; DEAD (Asp-Glu-Ala-Asp) box polypeptide 42; SF3b DEAD box protein; splicing factor 3B-associated 125 kDa protein; splicing factor 3b, subunit 8",
        "tax_id": 9606,
        "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908)",
        "pathway": " (hsa:11325);  (R-HSA-72163);  (R-HSA-72165);  (R-HSA-9770562);  (R-HSA-9918481);  (R-HSA-9943411)",
        "pathway_count": 6,
        "publication_count": 272,
        "publication_id_list": "10199952;10207048;10669729;10727850;10882114;11014198;11060040;11101529;11233976;11237011;11333026;11607023;11747608;11991638;12176931;12234937;12411573;12414731;12477934;12682017;14519844;14625303;14713954;14749727;14762106;15037765;15084397;15104674;15345747;15565158;15647753;15944288;16263726;16314458;16372014;16397294;16809785;17081983;17095540;17128255;17332742;17433364;17606899;17717186;17940139;18042460;18288197;18322460;18452278;18588927;18593880;18669648;18691976;19052544;19103666;19165350;19217410;19377511;19413330;19415658;19536130;19608861;19651622;19664995;19690332;20058876;20068231;20211137;20423332;20695905;20980672;21295486;21536652;2176635;21911577;22046413;22110043;22365833;22569126;22813749;22922743;22959432;22961380;23186163;23222130;23236153;23345524;23481700;23783831;23874216;24076191;24129315;24149845;24196718;24275569;24304693;24366607;24448447;24714562;24715725;24737827;24914973;2524422;25301780;25301781;25469497;25555158;25576301;2558966;25645385;25810538;25880248;25892735;26092250;26154972;26375851;26385511;26420826;26728094;26811146;26969736;26992070;27108190;27377154;27397612;27459055;27510544;27600516;27661449;27683217;27846572;27869121;27920218;28062851;28063628;28076346;28096519;28218747;28228285;28502770;28510447;28514659;28781166;28832583;28834231;28855257;28860189;28904123;28911096;29186539;29237092;29242379;29274231;29301961;29360106;29361316;29393594;29437277;29485866;29493099;29508533;29557506;29632046;29632711;2963332;29769354;29786170;29902443;30059200;30139799;30257008;30315122;30315277;30410026;30429286;30484775;30524438;30599162;30705154;30728453;30765414;30779550;30833945;30975767;31154438;31373491;31409651;31492838;31530632;31844290;31848261;31998317;32119511;32157095;32161166;32179686;32329775;32350084;32357974;32387766;32488085;32494006;32502341;32816001;32897882;32938616;32983136;33123756;33141586;33177556;33214551;33243851;33298915;33446560;33592498;33633747;33717175;33912179;33936100;33968037;33981976;34019948;34171305;34185709;34211107;34301950;34509645;34725712;34822310;34846842;34932366;35051231;35132862;35177536;35215846;35254053;35289036;35318648;35385551;35513511;35580925;35652295;36010968;36161446;36215666;36241641;36284347;36581221;36797247;37094262;37217939;3757028;37938771;38665916;39302247;39531497;39534244;40136647;40596516;40914422;8566756;8608946;8835860;9016565;9242493;9512519;9524131;9539711;9659921;9671485;9701291;9731529",
        "class_list": "",
        "function": "ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Cancer-associated mutations in SF3B1 disrupt the interaction between SF3B1 and DDX42., [RefSeq, PubMed]; Characterization of protein associated with the human 17S U2 snRNP and one of its stable subunits, SF3b; may facilitate the assembly of the 17S U2 snRNP, [RefSeq, PubMed]; Ddx42p represents the first example of a human DEAD box protein possessing RNA helicase, protein displacement and RNA annealing activities. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of N-terminal DDX42 is able to overcome Japanese encephalitis virus-induced antagonism of IFN responses and so may be important for Japanese encephalitis virus pathogenesis, [RefSeq, PubMed]; Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly. Publication Status: Online-Only, [RefSeq, PubMed]; The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA viruses., [RefSeq, PubMed]; This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; [The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA viruses]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 15,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 15,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 15,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 19,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 15,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NML1;A8KA43;O75619;Q68G51;Q96BK1;Q96HR7;Q9Y3V8",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;2.3.2.27;5.2.1.8;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.1.13.-;2.7.7.48;2.7.7.6;3.6.4.12;3.4.21.53;5.6.2.5;2.7.7.19;3.1.-.-;3.6.5.-;3.1.3.16;3.1.3.53;7.6.2.1;2.7.11.1;7.2.2.-;3.4.19.12;5.6.2.-;2.3.2.-;3.6.1.15;3.1.4.-;3.6.-.-;2.7.1.78;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.7.52;3.1.27.-;2.7.4.3",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0042981 regulation of apoptotic process;GO:0008104 intracellular protein localization;GO:1903241 U2-type prespliceosome assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 28.9,
        "record_id": "Q86XP3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N568-1",
        "uniprot_id": "DCLK2_HUMAN",
        "mass": 83606.0,
        "length": 766,
        "protein_name": "Serine/threonine-protein kinase DCLK2",
        "gene_name": "DCLK2",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein kinase DCLK2 isoform a",
        "refseq_ac": "NP_001035350",
        "gene_names_uniprotkb": "DCLK2; DCAMKL2; DCDC3B; DCK2",
        "gene_names_refseq": "CL2; CLICK-II; CLICK2; CLIK2; DCAMKL2; DCDC3B; DCDC3; DCK2; DCLK2",
        "protein_names_uniprotkb": "Serine/threonine-protein kinase DCLK2; 2.7.11.1; CL2; CLICK-II; CLICK2; CaMK-like CREB regulatory kinase 2; Doublecortin domain-containing protein 3B; Doublecortin-like and CAM kinase-like 2; Doublecortin-like kinase 2",
        "protein_names_refseq": "CaMK-like CREB regulatory kinase 2; doublecortin and CaM kinase-like 2; doublecortin domain-containing protein 3B; doublecortin-like and CAM kinase-like 2; serine/threonine-protein kinase DCLK2 isoform a; serine/threonine-protein kinase DCLK2",
        "tax_id": 9606,
        "disease": "dyslexia (Disease Ontology:DOID:4428)",
        "pathway": " (hsa:166614)",
        "pathway_count": 1,
        "publication_count": 39,
        "publication_id_list": "11237011;16869982;17344846;18075264;19413330;20236041;23186163;24715725;25512093;25576301;27600516;28832583;29242379;29557506;29632711;29786170;30429286;30524438;30779550;31844290;32157095;32357974;32387766;32897882;32938616;33141586;33298915;33592498;33936100;33968037;33981976;34087483;34171305;34509645;35051231;35561310;36010968;36284347;38211588",
        "class_list": "",
        "function": "Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma., [RefSeq, PubMed]; Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity)., [UniProtKB]; This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9J5Q9;Q59GC8;Q8N399",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007417 central nervous system development;GO:0000226 microtubule cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q8N568-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NCG7-1",
        "uniprot_id": "DGLB_HUMAN",
        "mass": 73732.0,
        "length": 672,
        "protein_name": "Diacylglycerol lipase-beta",
        "gene_name": "DAGLB",
        "organism": "Human",
        "refseq_name": "diacylglycerol lipase-beta isoform 2",
        "refseq_ac": "NP_001136408",
        "gene_names_uniprotkb": "DAGLB",
        "gene_names_refseq": "DAGLBETA; DAGLB; KCCR13L",
        "protein_names_uniprotkb": "Diacylglycerol lipase-beta; 3.1.1.116; 3.1.1.3; DAGL-beta; DGL-beta; KCCR13L; PUFA-specific triacylglycerol lipase; Sn1-specific diacylglycerol lipase beta",
        "protein_names_refseq": "DAGL-beta; DGL-beta; PUFA-specific triacylglycerol lipase; diacylglycerol lipase-beta isoform 2; sn1-specific diacylglycerol lipase beta",
        "tax_id": 9606,
        "disease": "alcohol use disorder (Disease Ontology:DOID:1574)",
        "pathway": " (hsa:221955);  (R-HSA-426048)",
        "pathway_count": 2,
        "publication_count": 55,
        "publication_id_list": "10348910;11237011;14610053;16303743;18096503;18669648;18691976;19126434;19664994;19690332;20058876;20068231;21418147;22969151;23186163;23481700;24714562;25576301;25892735;27115711;28228285;28467828;28832583;28904123;29242379;29393594;29476167;29493099;29557506;29786170;30315122;31844290;31848261;32157095;32350084;32357974;32387766;32897882;32938616;32983136;33392160;33968037;33981976;34171305;34357683;34405274;34433824;34509645;35051231;35154160;35251023;35580925;36010968;36284347;7295321",
        "class_list": "",
        "function": "Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; The purified DAGLbeta catalytic domain assay described here provides the basis for a relatively clean and convenient assay with the potential to be adapted for high-throughput drug discovery efforts., [RefSeq, PubMed]; This gene has been functionally characterized as a diacylglycerol-lipase (DAGL), referred to as DAGL beta.  These enzymes may have a role in the biosynthesis of the endocannabinoid 2-arachidnoyl glycerol (2-AG)., [RefSeq, PubMed]; We identified a novel HDL-C-associated variant which explained nearly half of the expression variance of DAGLB., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D2P3;B3KV90;B4DQU0;Q6PIX3;Q8N2N2;Q8N9S1;Q8TED3;Q8WXE6",
        "ec_number_list": "3.1.1.-;3.1.1.3;3.1.1.32;3.1.1.34;3.1.1.23;3.1.1.79;3.1.1.6;3.1.1.5;3.1.1.13;3.1.1.4;3.1.1.26;3.1.1.116;2.3.1.51",
        "go_molecular_function": "GO:0016298 lipase activity;GO:0046872 metal ion binding;GO:0047372 monoacylglycerol lipase activity;GO:0004806 triacylglycerol lipase activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane",
        "go_biological_process": "GO:0010898 positive regulation of triglyceride catabolic process;GO:0050727 regulation of inflammatory response;GO:0046340 diacylglycerol catabolic process;GO:0022008 neurogenesis;GO:0019369 arachidonate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "Q8NCG7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NFT6-1",
        "uniprot_id": "DBF4B_HUMAN",
        "mass": 67243.0,
        "length": 615,
        "protein_name": "Protein DBF4 homolog B",
        "gene_name": "DBF4B",
        "organism": "Human",
        "refseq_name": "protein DBF4 homolog B isoform 2",
        "refseq_ac": "NP_079380",
        "gene_names_uniprotkb": "DBF4B; ASKL1; DRF1",
        "gene_names_refseq": "ASKL1; CHIFB; DBF4B; DRF1; ZDBF1B",
        "protein_names_uniprotkb": "Protein DBF4 homolog B; ASK-like protein 1; Activator of S phase kinase-like protein 1; Chiffon homolog B; Dbf4-related factor 1",
        "protein_names_refseq": "ASK-like protein 1; DBF4 homolog B; DBF4 zinc finger B; Dbf4-related factor 1; activator of S-phase kinase-like protein 1; chiffon homolog B; protein DBF4 homolog B isoform 2; zinc finger, DBF-type containing 1B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80174)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "12065429;15668232;17062569;19111665;29262322;30379171;31217245;31530632;31844290;32157095;32357974;32387766;32938616;33298915;33912179;33968037;34185709;34509645;35051231;38865090",
        "class_list": "",
        "function": "ASKL1 in a complex with Cdc7 may play a role in normal progression of both S and M phases, [RefSeq, PubMed]; DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks., [RefSeq, PubMed]; Knockdown of the exon6-containing isoform (DBF4B-FL) significantly inhibits the tumorigenic potential of colon cancer. Overexpression of DBF4B-FL protects against DNA damage induced by SRSF1 knockdown., [RefSeq, PubMed]; Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle., [UniProtKB, PubMed, PubMed, PubMed]; Results describe a novel human protein, Drf1, related to both human and yeast Dbf4. Drf1 is a nuclear cell cycle-regulated protein which binds to Cdc7 and activates the kinase., [RefSeq, PubMed]; These results indicate that Ddk functions as an upstream regulator to monitor S-phase checkpoint signaling., [RefSeq, PubMed]; This gene encodes a regulator of the cell division cycle 7 homolog (S. cerevisiae) protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and, in complex with the cell division cycle 7 homolog (S. cerevisiae) protein, may facilitate M phase progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DX56;Q8TEX0;Q96B19;Q9H912",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0030295 protein kinase activator activity;GO:0003676 nucleic acid binding;GO:0043539 protein serine/threonine kinase activator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031431 Dbf4-dependent protein kinase complex",
        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:1901987 regulation of cell cycle phase transition;GO:0010571 positive regulation of nuclear cell cycle DNA replication",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q8NFT6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TF63-1",
        "uniprot_id": "DCNP1_HUMAN",
        "mass": 26704.0,
        "length": 244,
        "protein_name": "Dendritic cell nuclear protein 1",
        "gene_name": "DCANP1",
        "organism": "Human",
        "refseq_name": "dendritic cell nuclear protein 1",
        "refseq_ac": "NP_570900",
        "gene_names_uniprotkb": "DCANP1; C5orf20; DCNP1",
        "gene_names_refseq": "C5orf20; DCANP1; DCNP1",
        "protein_names_uniprotkb": "Dendritic cell nuclear protein 1; Dendritic cell nuclear protein-1; Dendritic cell-associated nuclear protein",
        "protein_names_refseq": "dendritic cell nuclear protein 1; dendritic cell-associated nuclear protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:140947)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11798177;16189510;17460725;20351714;20693543;23619526;29219947;36215666",
        "class_list": "",
        "function": "Binds with and transactivates the corticotropin-releasing hormone (CRH) promoter., [UniProtKB, PubMed]; In the Han Chinese population, common DCNP1 polymorphisms are unlikely to be important in the genetic susceptibility to MDD., [RefSeq, PubMed]; Marker rs12520799, in dendritic cell nuclear protein 1 on chromosome 5, yielded a significant association with lifetime major depression., [RefSeq, PubMed]; Molecular cloning and immunocytochemical analysis, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Our study reveals a connection between the major depression candidate protein DCNP1, circadian system and melatonin biosynthesis, which may contribute to the pathogenesis of depression., [RefSeq, PubMed]; The genetic polymorphism of DCNP1 may influence production of specific IgE by altering DC (Dendritic Cells)functions in the mite allergen presenting and/or processing. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans. [provided by RefSeq, Jul 2008]., [RefSeq]; We propose that full-length dendritic cell nucleus protein-1 may play a role in the pathogenesis of depressive disorders by enhancing corticotropin-releasing hormone expression in the hypothalamic paraventricular nucleus., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0048806 genitalia development;GO:0030432 peristalsis;GO:0031223 auditory behavior;GO:0048634 regulation of muscle organ development;GO:0071626 mastication",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q8TF63-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92564-1",
        "uniprot_id": "DCNL4_HUMAN",
        "mass": 34068.0,
        "length": 292,
        "protein_name": "DCN1-like protein 4",
        "gene_name": "DCUN1D4",
        "organism": "Human",
        "refseq_name": "DCN1-like protein 4 isoform 1",
        "refseq_ac": "NP_001035492",
        "gene_names_uniprotkb": "DCUN1D4; KIAA0276",
        "gene_names_refseq": "DCNL4; DCUN1D4",
        "protein_names_uniprotkb": "DCN1-like protein 4; DCNL4; DCUN1 domain-containing protein 4; Defective in cullin neddylation protein 1-like protein 4",
        "protein_names_refseq": "DCN1, defective in cullin neddylation 1, domain containing 4; DCN1-like protein 4 isoform 1; DCN1-like protein 4; DCUN1 domain-containing protein 4; defective in cullin neddylation protein 1-like protein 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23142);  (R-HSA-8951664)",
        "pathway_count": 2,
        "publication_count": 137,
        "publication_id_list": "10.1101/2023.09.13.557529;10535940;10597293;10811609;10878807;10973499;11069780;11237011;11259415;11292861;11292862;11454738;11585840;11733065;11961546;12101228;12186903;12504025;12504026;12526791;12538644;12609982;12682069;12759363;12816948;14690597;14757770;15282312;15361859;15367669;15537541;15572695;15574592;15601839;15652483;15688063;15694336;15799966;16171779;16401342;16547496;16647857;16707496;16790436;16943200;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18093314;18206966;18775313;18776931;18805092;18826954;18851830;18926707;19250909;19321346;19617556;19748355;21447816;21463634;21778237;21863050;21940857;22306028;22466964;22537386;22959436;23201271;23333871;23401859;23453757;23535662;23535663;23563313;23583660;23912815;23986495;24076655;24366543;24636985;24793695;24793696;25218447;25314029;25349211;25355947;25531226;26344709;26375851;26460955;26632597;26906416;27030794;27222660;27565346;27600516;27846572;27920218;28115426;28218747;28228285;28514659;28581483;28832583;29153394;29242379;29437277;29557506;29786170;30315122;30379171;30610225;30833945;31154438;31844290;32005965;32157095;32284348;32938616;33444648;33592498;33912179;33968037;34171305;35051231;35561310;36241641;36284347;9790970;9887101;9891082",
        "class_list": "",
        "function": "Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which are necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs)., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DH25;Q7Z3F3;Q7Z6B8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0032182 ubiquitin-like protein binding;GO:0097602 cullin family protein binding;GO:0031624 ubiquitin conjugating enzyme binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000151 ubiquitin ligase complex",
        "go_biological_process": "GO:0045116 protein neddylation;GO:2000436 positive regulation of protein neddylation",
        "synthesized_glycan_count": 0,
        "hit_score": 14.2,
        "record_id": "Q92564-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92904-1",
        "uniprot_id": "DAZL_HUMAN",
        "mass": 33178.0,
        "length": 295,
        "protein_name": "Deleted in azoospermia-like",
        "gene_name": "DAZL",
        "organism": "Human",
        "refseq_name": "deleted in azoospermia-like isoform 1",
        "refseq_ac": "NP_001177740",
        "gene_names_uniprotkb": "DAZL; DAZH; DAZL1; DAZLA; SPGYLA",
        "gene_names_refseq": "DAZH; DAZL1; DAZLA; DAZL; SPGYLA",
        "protein_names_uniprotkb": "Deleted in azoospermia-like; DAZ homolog; DAZ-like autosomal; Deleted in azoospermia-like 1; SPGY-like-autosomal",
        "protein_names_refseq": "DAZ homolog; DAZ-like autosomal; SPGY-like-autosomal; deleted in azoospermia-like 1; deleted in azoospermia-like isoform 1; germline specific RNA binding protein; spermatogenesis gene on the Y-like autosomal; testis secretory sperm-binding protein Li 204a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:1618)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "10857750;11237011;11390979;12414900;12511597;22021443;27280388;31429579;32157095;33542261;33912179;34653405;36273819;36434389;38588931;8896558;8968755;8968756;9294855",
        "class_list": "",
        "function": "A novel cancer-germline gene DAZL promotes progression and cisplatin resistance of non-small cell lung cancer by upregulating JAK2 and MCM8., [RefSeq, PubMed]; Association of DAZL polymorphisms and DAZ deletion with male infertility: a systematic review and meta-analysis., [RefSeq, PubMed]; DAZL regulates proliferation of human primordial germ cells by direct binding to precursor miRNAs and enhances DICER processing activity., [RefSeq, PubMed]; Direct reprogramming of human Sertoli cells into male germline stem cells with the self-renewal and differentiation potentials via overexpressing DAZL/DAZ2/BOULE genes., [RefSeq, PubMed]; RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity)., [UniProtKB]; The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]., [RefSeq]; The marker of alkyl DNA base damage, N7-methylguanine, is associated with semen quality in men. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O15396;Q5HYB4;Q92909",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0008494 translation activator activity;GO:0003730 mRNA 3'-UTR binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005840 ribosome;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0007281 germ cell development;GO:0070935 3'-UTR-mediated mRNA stabilization;GO:0045948 positive regulation of translational initiation;GO:0030154 cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q92904-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96C86-1",
        "uniprot_id": "DCPS_HUMAN",
        "mass": 38609.0,
        "length": 337,
        "protein_name": "m7GpppX diphosphatase",
        "gene_name": "DCPS",
        "organism": "Human",
        "refseq_name": "m7GpppX diphosphatase isoform 2",
        "refseq_ac": "NP_054745",
        "gene_names_uniprotkb": "DCPS; DCS1; HINT5; HSPC015",
        "gene_names_refseq": "ARS; DCPS; DCS1; HINT-5; HINT5; HSL1; HSPC015",
        "protein_names_uniprotkb": "m7GpppX diphosphatase; 3.6.1.59; DCS-1; Decapping scavenger enzyme; HINT-5; Hint-related 7meGMP-directed hydrolase; Histidine triad nucleotide-binding protein 5; Histidine triad protein member 5; Scavenger mRNA-decapping enzyme DcpS",
        "protein_names_refseq": "5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase; decapping scavenger enzyme; epididymis secretory sperm binding protein; heat shock-like protein 1; hint-related 7meGMP-directed hydrolase; histidine triad nucleotide-binding protein 5; histidine triad protein member 5; homolog of C. elegans 7meGMP-directed hydrolase dcs-1; m7GpppX diphosphatase isoform 2; m7GpppX diphosphatase; mRNA decapping enzyme; scavenger mRNA-decapping enzyme DcpS",
        "tax_id": 9606,
        "disease": "Al-Raqad syndrome (MONDO:MONDO:0014648)",
        "pathway": " (hsa:28960);  (R-HSA-429958)",
        "pathway_count": 2,
        "publication_count": 90,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11283721;11747811;12198172;12871939;14523240;14749774;15068804;15231747;15273322;15383679;15475613;15769464;16140270;16141059;17174896;17245413;17545563;18426921;18441014;18725266;18839960;19060886;19225159;19239894;19608861;22223895;22985415;23186163;23223233;23301498;24714562;24715725;25576301;25645385;25701870;25712129;25892735;26154972;26992070;27600516;27846572;27862975;27920218;28218747;28228285;28510447;28649982;28832583;29242379;29493099;29508533;29557506;29632711;29769354;30315122;30410026;31217245;31844290;32157095;32357974;32387766;32488085;32502341;32723815;32770650;32938616;32983136;33123756;33141586;33298915;33592498;33717175;33912179;33968037;33981976;34087483;34185709;34509645;35051231;35154160;35580925;35705054;36010968;36215666;36241641;36284347;40307207;40914422",
        "class_list": "",
        "function": "Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Leukoencephalopathy in Al-Raqad syndrome: Expanding the clinical and neuroimaging features caused by a biallelic novel missense variant in DCPS., [RefSeq, PubMed]; M7GDP breakdown by DcpS should prevent misincorporation of methylated nucleotides in nucleic acids and could generate a unique indicator allowing the cell to monitor mRNA decay., [RefSeq, PubMed]; Molecular basis of the selective processing of short mRNA substrates by the DcpS mRNA decapping enzyme., [RefSeq, PubMed]; Structural and biochemical analysis suggests an autoregulatory mechanism whereby premature decapping mRNA is prevented by blocking the conformational changes that are required to form a closed productive active site capable of cap hydrolysis., [RefSeq, PubMed]; The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function., [RefSeq, PubMed]; This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5' mRNA cap structure, which appear in the 3' -> 5' mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 33,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NHL8;Q9Y2S5",
        "ec_number_list": "3.6.1.59;3.6.1.52;3.6.1.62;3.6.1.10;3.6.1.61",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0004532 RNA exonuclease activity;GO:0140932 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0045292 mRNA cis splicing, via spliceosome;GO:0110156 mRNA methylguanosine-cap decapping",
        "synthesized_glycan_count": 0,
        "hit_score": 9.5,
        "record_id": "Q96C86-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96EP5-1",
        "uniprot_id": "DAZP1_HUMAN",
        "mass": 43383.0,
        "length": 407,
        "protein_name": "DAZ-associated protein 1",
        "gene_name": "DAZAP1",
        "organism": "Human",
        "refseq_name": "DAZ-associated protein 1 isoform b",
        "refseq_ac": "NP_061832",
        "gene_names_uniprotkb": "DAZAP1",
        "gene_names_refseq": "DAZAP1",
        "protein_names_uniprotkb": "DAZ-associated protein 1; Deleted in azoospermia-associated protein 1",
        "protein_names_refseq": "DAZ-associated protein 1 isoform b; deleted in azoospermia-associated protein 1; testicular tissue protein Li 50",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); gamma-glutamyl transpeptidase deficiency (Disease Ontology:DOID:0111257); gestational diabetes (Disease Ontology:DOID:11714); biliary atresia (Disease Ontology:DOID:13608); melanoma (Disease Ontology:DOID:1909); aflatoxins-related hepatocellular carcinoma (Disease Ontology:DOID:5022); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); diabetic neuropathy (Disease Ontology:DOID:9743)",
        "pathway": " (hsa:26528)",
        "pathway_count": 1,
        "publication_count": 79,
        "publication_id_list": "10857750;11237011;14654843;15744350;16209998;16848763;16959974;17525332;22001406;22223895;24129315;24452013;24715725;25645385;25880248;25892735;26154972;26992070;27600516;27846572;27862975;27920218;28218747;28228285;28510447;28514659;28649982;28832583;28834231;29242379;29314611;29393594;29437277;29493099;29508533;29557506;29632711;29769354;29786170;30315122;30833945;31154438;31217245;31222486;31530632;31844290;32157095;32308763;32350084;32357974;32502341;32897882;32938616;32983136;33141586;33214551;33358859;33592498;33717175;33912179;33936100;33968037;33981976;34019948;34171305;34185709;34211107;34932366;35051231;35091997;35154160;35251023;35318648;35580925;36242590;36284347;36581221;37349114;38665916",
        "class_list": "",
        "function": "DAZAP1 facilitates the alternative splicing of KITLG to promote multiple myeloma cell proliferation via ERK signaling pathway., [RefSeq, PubMed]; DAZAP1 overexpression promotes growth of HCC cell lines: a primary study using CEUS., [RefSeq, PubMed]; Data suggest that MEF2D/DAZAP1 and/or DAZAP1/MEF2D contribute to leukemogenesis by altering signaling pathways normally regulated by wild-type MEF2D and DAZAP1, [RefSeq, PubMed]; In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with PXR to Negatively Regulate CYP3A4 Induction., [RefSeq, PubMed]; RNA binding protein DAZAP1 promotes HCC progression and regulates ferroptosis by interacting with SLC7A11 mRNA. Erratum:[Exp Cell Res. 2021 Nov 15;408(2):112867. doi: 10.1016/j.yexcr.2021.112867. PMID: 34648845], [RefSeq, PubMed]; RNA-binding protein, which may be required during spermatogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Starvation-induced suppression of DAZAP1 by miR-10b integrates splicing control into TSC2-regulated oncogenic autophagy in esophageal squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; This study shows expression patterns of DAZAP1 in human corpus luteum cells and demonstrates the in vivo interaction of DAZ-like protein (DAZL) with DAZAP1., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 14,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96MJ3;Q9NRR9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0008266 poly(U) RNA binding;GO:0034046 poly(G) binding;GO:0035613 RNA stem-loop binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0007283 spermatogenesis;GO:0030154 cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 8.2,
        "record_id": "Q96EP5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96JK2-1",
        "uniprot_id": "DCAF5_HUMAN",
        "mass": 103963.0,
        "length": 942,
        "protein_name": "DDB1- and CUL4-associated factor 5",
        "gene_name": "DCAF5",
        "organism": "Human",
        "refseq_name": "DDB1- and CUL4-associated factor 5 isoform 2",
        "refseq_ac": "NP_001271135",
        "gene_names_uniprotkb": "DCAF5; BCRG2; KIAA1824; WDR22",
        "gene_names_refseq": "BCRG2; BCRP2; D14S1461E; DCAF5; WDR22",
        "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 5; BCRP2; Breakpoint cluster region protein 2; WD repeat-containing protein 22",
        "protein_names_refseq": "DDB1- and CUL4-associated factor 5 isoform 2; WD repeat-containing protein 22; breakpoint cluster region protein, uterine leiomyoma, 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8816);  (R-HSA-8951664)",
        "pathway_count": 2,
        "publication_count": 165,
        "publication_id_list": "10535940;10597293;10811609;10878807;10973499;11069780;11237011;11259415;11292861;11292862;11454738;11585840;11733065;11961546;12101228;12186903;12504025;12504026;12526791;12538644;12609982;12682069;12759363;12816948;14690597;14757770;15282312;15361859;15367669;15537541;15572695;15574592;15601839;15652483;15688063;15694336;15799966;16171779;16401342;16547496;16647857;16707496;16790436;16943200;16949367;16964240;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18093314;18206966;18452278;18775313;18776931;18805092;18826954;18851830;18926707;19250909;19321346;19617556;19664994;19690332;19748355;21447816;21463634;21778237;21863050;21940857;22306028;22466964;22537386;22959436;23186163;23201271;23333871;23401859;23453757;23481700;23535662;23535663;23563313;23583660;23912815;23986495;24076655;24275569;24366543;24636985;24715725;24793695;24793696;25314029;25349211;25355947;25418920;25531226;25576301;26344709;26460955;26632597;26811146;26906416;26992070;27030794;27222660;27565346;27862975;27920218;28063628;28115426;28218747;28228285;28649982;28832583;28834231;28904123;29153394;29242379;29393594;29437277;29493099;29557506;29632046;29691401;29786170;29789417;30315122;30410026;30429286;30442713;30610225;31844290;32005965;32157095;32265295;32284348;32357974;32387766;32488085;32938616;32983136;33444648;33537174;33592498;33691108;33912179;33968037;33981976;34087483;34171305;34932366;35051231;35580925;36010968;37938771;38538798;9740667;9790970;9887101;9891082",
        "class_list": "",
        "function": "Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) (PubMed:29691401, PubMed:30442713). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 (PubMed:29691401, PubMed:30442713)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Erratum:[Nature. 2024 May;629(8012):E12. doi: 10.1038/s41586-024-07402-3. PMID: 38684813], [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RN31;G3V4J7;O60559;Q8N3V3;Q8N3V5",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0080008 Cul4-RING E3 ubiquitin ligase complex",
        "go_biological_process": "GO:0045717 negative regulation of fatty acid biosynthetic process;GO:0016567 protein ubiquitination;GO:2000036 regulation of stem cell population maintenance",
        "synthesized_glycan_count": 0,
        "hit_score": 16.6,
        "record_id": "Q96JK2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96SD1-1",
        "uniprot_id": "DCR1C_HUMAN",
        "mass": 78436.0,
        "length": 692,
        "protein_name": "Protein artemis",
        "gene_name": "DCLRE1C",
        "organism": "Human",
        "refseq_name": "protein artemis isoform a",
        "refseq_ac": "NP_001029027",
        "gene_names_uniprotkb": "DCLRE1C; ARTEMIS; ASCID; SCIDA; SNM1C",
        "gene_names_refseq": "A-SCID; DCLRE1C; DCLREC1C; RS-SCID; SCIDA; SNM1C",
        "protein_names_uniprotkb": "Protein artemis; 3.1.-.-; DNA cross-link repair 1C protein; Protein A-SCID; SNM1 homolog C; SNM1-like protein; hSNM1C",
        "protein_names_refseq": "DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae); SNM1 homolog C; SNM1-like protein; protein artemis isoform a; protein artemis; severe combined immunodeficiency, type a (Athabascan)",
        "tax_id": 9606,
        "disease": "Omenn syndrome (Disease Ontology:DOID:0060010); severe combined immunodeficiency with sensitivity to ionizing radiation (Disease Ontology:DOID:0090012); common variable immunodeficiency (Disease Ontology:DOID:12177); severe combined immunodeficiency (Disease Ontology:DOID:627)",
        "pathway": " (hsa:64421);  (R-HSA-5693571)",
        "pathway_count": 2,
        "publication_count": 125,
        "publication_id_list": "10572166;10757784;11237011;11336668;11493912;11604075;11702069;11955432;12023295;12055248;12077346;12177301;12186630;12231622;12406895;12509254;12569164;12592555;12897153;12921762;12947387;14561766;14744996;15071507;15177042;15451442;15456891;15468306;15574326;15574327;15723659;15731174;15811628;15936993;16061182;16093244;16439204;16439205;1660029;16600297;16874298;16914548;17290226;17470781;18046455;18397950;19505854;22179609;22529269;22544926;23219551;23306437;23333306;23505375;23523427;23727112;24236237;25418920;25512557;25576301;25645385;25818648;25841101;25880248;26154972;26375851;26992070;27600516;27846572;28218747;28228285;28832583;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632711;30059200;30315122;30779550;31154438;31530632;31844290;31848261;31998317;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33091337;33109704;33141586;33592498;33691108;33717175;33912179;33936100;33968037;34171305;34210101;34405274;34509645;34932366;35051231;35318648;35561310;35580925;35801871;36241641;36270581;36546626;37938771;8422676;9259561;9430729;9512523;9826654",
        "class_list": "",
        "function": "A nonsense founder mutation discovered in exon 8 of Artemis results in the truncation of the deduced protein product and indicates that the SNM1-like gene (Artemis) is the gene responsible for SCID in Athabascan-speaking Native Americans., [RefSeq, PubMed]; DNA-PKcs regulates Artemis by both phosphorylation and complex formation to permit enzymatic activities that are critical for the hairpin-opening step of V(D)J recombination and for the 5' and 3' overhang processing in nonhomologous DNA end joining., [RefSeq, PubMed]; Dynamics of the Artemis and DNA-PKcs Complex in the Repair of Double-Strand Breaks. Review article, [RefSeq, PubMed]; Lentiviral Gene Therapy for Artemis-Deficient SCID., [RefSeq, PubMed]; Nuclease involved in DNA non-homologous end joining (NHEJ); required for double-strand break repair and V(D)J recombination (PubMed:11336668, PubMed:11955432, PubMed:12055248, PubMed:14744996, PubMed:15071507, PubMed:15574326, PubMed:15936993). Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments (PubMed:11336668, PubMed:11955432, PubMed:14744996). V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs) (PubMed:11336668, PubMed:11955432, PubMed:14744996). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends (PubMed:11336668, PubMed:11955432, PubMed:14744996). These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively (PubMed:11336668, PubMed:11955432, PubMed:14744996). This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC (PubMed:11955432, PubMed:15071507, PubMed:15574326, PubMed:15936993). The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint (PubMed:11955432). Also required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (PubMed:15456891, PubMed:15468306, PubMed:15574327, PubMed:15811628)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Staring at the Naked Goddess: Unraveling the Structure and Reactivity of Artemis Endonuclease Interacting with a DNA Double Strand. Publication Status: Online-Only, [RefSeq, PubMed]; Structural analysis of the basal state of the Artemis:DNA-PKcs complex., [RefSeq, PubMed]; This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 20,
        "reported_mutagensis": 20,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DRT6;Q1HCL2;Q5JSR4;Q5JSR5;Q5JSR7;Q5JSR8;Q5JSR9;Q5JSS0;Q5JSS7;Q6PK14;Q8N101;Q8N132;Q8TBW9;Q9BVW9;Q9HAM4",
        "ec_number_list": "2.3.2.27;3.1.4.-;2.3.2.26;2.1.1.357;4.2.99.18;5.6.2.4;6.5.1.1;3.1.-.-;2.3.2.23;2.7.11.1;3.6.-.-;2.3.1.48;2.3.1.-;2.7.7.7;4.2.99.-",
        "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0004519 endonuclease activity;GO:0000014 single-stranded DNA endodeoxyribonuclease activity;GO:0035312 5'-3' DNA exonuclease activity;GO:0008409 5'-3' exonuclease activity",
        "go_cellular_component": "GO:0070419 nonhomologous end joining complex;GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0006310 DNA recombination;GO:0000723 telomere maintenance;GO:0002250 adaptive immune response;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0036297 interstrand cross-link repair",
        "synthesized_glycan_count": 0,
        "hit_score": 12.8,
        "record_id": "Q96SD1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BYW3-1",
        "uniprot_id": "DB126_HUMAN",
        "mass": 12174.0,
        "length": 111,
        "protein_name": "Beta-defensin 126",
        "gene_name": "DEFB126",
        "organism": "Human",
        "refseq_name": "beta-defensin 126 isoform 1 preproprotein",
        "refseq_ac": "NP_112193",
        "gene_names_uniprotkb": "DEFB126; C20orf8; DEFB26",
        "gene_names_refseq": "C20orf8; DEFB-26; DEFB126; DEFB26; HBD26; bA530N10.1; hBD-26",
        "protein_names_uniprotkb": "Beta-defensin 126; Beta-defensin 26; DEFB-26; Defensin, beta 126; ESP13.2; Epididymal secretory protein 13.2; HBD26",
        "protein_names_refseq": "beta-defensin 126 isoform 1 preproprotein; epididymal secretory protein ESP13.2; epididymis secretory sperm binding protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81623);  (R-HSA-1461957);  (R-HSA-1461973)",
        "pathway_count": 3,
        "publication_count": 26,
        "publication_id_list": "10491631;10521347;10914484;11085990;11702237;11854508;11934878;12620395;12949495;17928628;18006661;19373462;20214904;20385753;20483750;21122132;21775668;23229569;25721098;26832966;30529003;31474436;31504198;35381696;39894887;9541493",
        "class_list": "",
        "function": "<i>DEFB126</i> polymorphisms and association with idiopathic asthenozoospermia in China., [RefSeq, PubMed]; Beta-defensin126 is correlated with sperm motility in fertile and infertile mendagger., [RefSeq, PubMed]; Data indicate a significant contribution of the frame-shift polymorphism of defensin beta 126 (DEFB126) rs11467497 to male infertility., [RefSeq, PubMed]; Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. The encoded protein is highly similar to an epididymal-specific secretory protein (ESP13.2) from cynomolgus monkey. Mutation of this gene is associated with impaired sperm function. [provided by RefSeq, Nov 2014]., [RefSeq]; Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte (By similarity). In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation (PubMed:19373462, PubMed:23229569)., [UniProtKB, PubMed, UniProtKB, PubMed]; It is a immune component extensively expressed in mucosa and epidermis, which are responsible for the first line of host defense., [RefSeq, PubMed]; The role of DEFB126 variation in male infertility and medically assisted reproduction technique outcome., [RefSeq, PubMed]; These results demonstrate that the DEFB126 core peptide has critical functions in parallel to its C-terminal tail by showing LPS-binding activity, anti-inflammatory effects and intracellular regulatory function. In addition, DEFB126 displays antimicrobial activity against E. coli, S. aureus, and C. elegans., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q562G3;Q9H1M5",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0007338 single fertilization",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q9BYW3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9HBH1-1",
        "uniprot_id": "DEFM_HUMAN",
        "mass": 27013.0,
        "length": 243,
        "protein_name": "Peptide deformylase, mitochondrial",
        "gene_name": "PDF",
        "organism": "Human",
        "refseq_name": "peptide deformylase, mitochondrial precursor",
        "refseq_ac": "NP_071736",
        "gene_names_uniprotkb": "PDF; PDF1A",
        "gene_names_refseq": "PDF",
        "protein_names_uniprotkb": "Peptide deformylase, mitochondrial; 3.5.1.88; Polypeptide deformylase",
        "protein_names_refseq": "peptide deformylase, mitochondrial precursor; peptide deformylase-like protein; polypeptide deformylase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64146)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "11060042;14532271;14637138;15489958;19236878;22554513;23481700;23815882;24675470;26154972;26375851;26811146;27023495;27846572;27920218;28904123;29393594;31844290;31848261;31937595;32157095;32161166;32350084;32387766;32502341;32897882;32938616;33141586;33912179;33936100;34357683;35251023;36010968",
        "class_list": "",
        "function": "C-myc regulated the expression of human PDF. Publication Status: Online-Only, [RefSeq, PubMed]; Compound M7594_0037 exhibited potent anticancer activities against HeLa, A549 and MCF-7 cell lines with IC50s of 35.26, 29.63 and 24.63 muM, respectively. Molecular docking studies suggested that M7594_0037 and its three derivatives could interact with Human peptide deformylase by several conserved hydrogen bonds. Publication Status: Online-Only, [RefSeq, PubMed]; Protein synthesis proceeds after formylation of methionine by methionyl-tRNA formyl transferase (FMT) and transfer of the charged initiator f-met tRNA to the ribosome. In eubacteria and eukaryotic organelles the product of this gene, peptide deformylase (PDF), removes the formyl group from the initiating methionine of nascent peptides. In eubacteria, deformylation of nascent peptides is required for subsequent cleavage of initiating methionines by methionine aminopeptidase. The discovery that a natural inhibitor of PDF, actinonin, acts as an antimicrobial agent in some bacteria has spurred intensive research into the design of bacterial-specific PDF inhibitors. In human cells, only mitochondrial proteins have N-formylation of initiating methionines. Protein inhibitors of PDF or siRNAs of PDF block the growth of cancer cell lines but have no effect on normal cell growth. In humans, PDF function may therefore be restricted to rapidly growing cells. [provided by RefSeq, Nov 2008]., [RefSeq]; Removes the formyl group from the N-terminal Met of newly synthesized proteins., [UniProtKB, PubMed, PubMed, PubMed]; The inhibition of HsPDF may provide an explanation for the mechanism by which actinonin is cytotoxic against various human tumor cell lines., [RefSeq, PubMed]; These data reveals that PDF has several transcription start sites, the most important of which only 18 bp from the initiation codon., [RefSeq, PubMed]; This is the first report showing that PDF is over-expressed in breast, colon, and lung cancers Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8WUN6",
        "ec_number_list": "3.5.1.88",
        "go_molecular_function": "GO:0042586 peptide deformylase activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005739 mitochondrion",
        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043687 post-translational protein modification;GO:0006412 translation;GO:0018206 peptidyl-methionine modification",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q9HBH1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NQZ3-1",
        "uniprot_id": "DAZ1_HUMAN",
        "mass": 82764.0,
        "length": 744,
        "protein_name": "Deleted in azoospermia protein 1",
        "gene_name": "DAZ1",
        "organism": "Human",
        "refseq_name": "deleted in azoospermia protein 1 isoform 1",
        "refseq_ac": "NP_004072",
        "gene_names_uniprotkb": "DAZ1; DAZ; SPGY",
        "gene_names_refseq": "DAZ1; DAZ; SPGY",
        "protein_names_uniprotkb": "Deleted in azoospermia protein 1",
        "protein_names_refseq": "deleted in azoospermia protein 1 isoform 1; deleted in azoospermia protein 1; testicular tissue protein Li 49",
        "tax_id": 9606,
        "disease": "Y-linked spermatogenic failure 2 (Disease Ontology:DOID:0070187)",
        "pathway": " (hsa:1617)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "10857750;10903443;10936047;11058556;11095434;11237011;11390979;11870237;12511597;12752250;12801575;16275261;18385127;19223287;19865085;31429579;33034826;36434389;36591797;37586075",
        "class_list": "",
        "function": "Association of DAZL polymorphisms and DAZ deletion with male infertility: a systematic review and meta-analysis. Review article, [RefSeq, PubMed]; CXCL10 Recruitment of gammadelta T Cells into the Hypoxic Bone Marrow Environment Leads to IL17 Expression and Multiple Myeloma Progression., [RefSeq, PubMed]; Partial-AZFc deletions in Chilean men with primary spermatogenic impairment: gene dosage and Y-chromosome haplogroups., [RefSeq, PubMed]; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells., [UniProtKB, PubMed]; This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains three copies of the 10.8 kb repeat. However, no transcripts containing three copies of the RRM domain have been described; thus the RefSeq for this gene contains only two RRM domains. [provided by RefSeq, Jul 2008]., [RefSeq]; Y-chromosome haplogroups and Azoospermia Factor (AZF) analysis in Tunisian infertile male., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q1RMF9;Q9NQZ4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008494 translation activator activity;GO:0003730 mRNA 3'-UTR binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0070935 3'-UTR-mediated mRNA stabilization;GO:0045948 positive regulation of translational initiation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q9NQZ3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NRG7-2",
        "uniprot_id": "D39U1_HUMAN",
        "mass": 31077.0,
        "length": 293,
        "protein_name": "Epimerase family protein SDR39U1",
        "gene_name": "SDR39U1",
        "organism": "Human",
        "refseq_name": "epimerase family protein SDR39U1 isoform 1",
        "refseq_ac": "NP_064580",
        "gene_names_uniprotkb": "SDR39U1; C14orf124; HCDI",
        "gene_names_refseq": "C14orf124; HCDI; SDR39U1",
        "protein_names_uniprotkb": "Epimerase family protein SDR39U1; 1.1.1.-; Short-chain dehydrogenase/reductase family 39U member 1",
        "protein_names_refseq": "epimerase family protein SDR39U1 isoform 1; epimerase family protein SDR39U1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:56948)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "19027726;20068231;28228285;29632046;32387766;33141586;33298915;33968037;34171305;34509645;35051231;36010968;36241641",
        "class_list": "",
        "function": "Putative NADP-dependent oxidoreductase., [UniProtKB]; This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) superfamily, which includes both classical and extended types. The encoded protein represents an extended type, with similarity to epimerases. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ZW71;Q9BVQ3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0016491 oxidoreductase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q9NRG7-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P80217-1",
        "uniprot_id": "IN35_HUMAN",
        "mass": 31546.0,
        "length": 286,
        "protein_name": "Interferon-induced 35 kDa protein",
        "gene_name": "IFI35",
        "organism": "Human",
        "refseq_name": "interferon-induced 35 kDa protein isoform 2",
        "refseq_ac": "NP_001317159",
        "gene_names_uniprotkb": "IFI35; IFP35",
        "gene_names_refseq": "IFI35; IFP35",
        "protein_names_uniprotkb": "Interferon-induced 35 kDa protein; IFP 35; Ifi-35",
        "protein_names_refseq": "IFP 35; ifi-35; interferon-induced 35 kDa protein isoform 2; interferon-induced 35 kDa protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3430);  (R-HSA-909733)",
        "pathway_count": 2,
        "publication_count": 121,
        "publication_id_list": "10395669;10542297;10779520;10950963;10982844;11092454;11337497;11377645;11404376;11585831;11911807;12029096;12665801;12766484;12842042;14769151;15047845;15312780;15449939;15778442;16009940;16171819;16987978;17251292;1730654;17351669;17969444;18035202;18575461;20130243;20363976;20643137;2211721;23061660;23121362;23481700;24417533;25371710;25418920;25645385;26154972;26342464;26375851;27452731;27846572;27920218;28228285;28510447;28514659;28832583;28904123;29038465;29242379;29331515;29350881;29393594;29508533;29557506;29632046;29786170;30315122;30429286;30485383;31844290;32032529;32113509;32157095;32350084;32387766;32488085;32502341;32511913;32574262;32661006;32758689;32781067;32862111;32938616;32983136;33117408;33189161;33193462;33298915;33396578;33592498;33691108;33968037;34171305;34357683;34362845;34509645;35051231;35154160;35318648;35580925;36241641;36284347;37938771;40914422;6162102;6548414;688397;7510216;7526154;7537377;7540766;8197134;8232552;8288566;8605876;8621447;8702790;8938427;8954125;9096384;9121453;9242679;9334213;9660177;9847332;9861020",
        "class_list": "",
        "function": "Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (PubMed:10779520, PubMed:10950963). In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production (PubMed:26342464). In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (PubMed:29038465). Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Dissociation of the IFN-induced protein IFP35 from NMI is a newly defined specific cytoplasmic event occurring during apoptosis., [RefSeq, PubMed]; IFI35 as a biomolecular marker of neuroinflammation and treatment response in multiple sclerosis., [RefSeq, PubMed]; IFP35 family proteins promote neuroinflammation and multiple sclerosis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JGX1;Q92984;Q99537;Q9BV98",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0045087 innate immune response;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0050729 positive regulation of inflammatory response;GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 12.4,
        "record_id": "P80217-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5T7B8-1",
        "uniprot_id": "KIF24_HUMAN",
        "mass": 151903.0,
        "length": 1368,
        "protein_name": "Kinesin-like protein KIF24",
        "gene_name": "KIF24",
        "organism": "Human",
        "refseq_name": "kinesin-like protein KIF24",
        "refseq_ac": "NP_919289",
        "gene_names_uniprotkb": "KIF24; C9orf48",
        "gene_names_refseq": "C9orf48; KIF24; bA571F15.4",
        "protein_names_uniprotkb": "Kinesin-like protein KIF24",
        "protein_names_refseq": "kinesin-like protein KIF24",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:347240);  (R-HSA-5620912)",
        "pathway_count": 2,
        "publication_count": 81,
        "publication_id_list": "11237011;16357211;17574030;17646400;17719545;18037885;18491316;18691976;18694559;18801063;19004860;19081074;19369195;19940019;20058876;20230748;20308558;20399632;20558667;20670673;21273506;21422230;21548880;21565611;21620453;21725307;21792235;22179047;22433857;22653444;23141531;23141541;23186163;23253480;23348840;23400999;23530209;23747070;23769972;23789104;24053599;24089205;24231678;24421332;24469809;24714562;24715725;24982133;25047611;25313408;25576301;26290419;26992070;28832583;28834231;28904123;29242379;29331515;29393594;29493099;29557506;29786170;30375385;31844290;32157095;32387766;32897882;32938616;32983136;33298915;33592498;33691108;33717175;34087483;34171305;35051231;35580925;35748595;36010968;36241641;39894887",
        "class_list": "",
        "function": "Biallelic KIF24 Variants Are Responsible for a Spectrum of Skeletal Disorders Ranging From Lethal Skeletal Ciliopathy to Severe Acromesomelic Dysplasia., [RefSeq, PubMed]; KIF24 rs17350674 polymorphism likely acts as a risk factor for sporadic Lobar Degeneration GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385)., [UniProtKB, PubMed, PubMed, PubMed]; Study found that loss of Kif24 leads to the disappearance of CP110 from mother centrioles in cycling cells able to form cilia; thus, identifying a centriolar kinesin that specifically remodels a subset of microtubules, thereby regulating cilia assembly., [RefSeq, PubMed]; This gene encodes a member of the kinesin superfamily of microtubule-based motor proteins which are involved in the intracellular transport of membranous organelles, protein complexes, and mRNAs. They also play critical roles in mitosis, morphogenesis, and signal transduction. The encoded protein contains an N-terminal sterile alpha motif (SAM) domain and an ATP-binding kinesin motor domain. It binds centriolar coiled coil protein 110 and centrosomal protein 97 and localizes to the mother centriole to regulate ciliogenesis by controlling microtubule polymerization. [provided by RefSeq, Mar 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 34,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2TB93;Q5T7B5;Q5T7B7;Q6ZU97;Q6ZUZ2;Q86XZ0;Q9NV43",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0003777 microtubule motor activity",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005814 centriole;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0060271 cilium assembly;GO:0007018 microtubule-based movement;GO:0007019 microtubule depolymerization",
        "synthesized_glycan_count": 0,
        "hit_score": 8.4,
        "record_id": "Q5T7B8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WXW3-1",
        "uniprot_id": "PIBF1_HUMAN",
        "mass": 89805.0,
        "length": 757,
        "protein_name": "Progesterone-induced-blocking factor 1",
        "gene_name": "PIBF1",
        "organism": "Human",
        "refseq_name": "progesterone-induced-blocking factor 1 isoform 2",
        "refseq_ac": "NP_006337",
        "gene_names_uniprotkb": "PIBF1; C13orf24; PIBF",
        "gene_names_refseq": "C13orf24; CEP90; JBTS33; PIBF1; PIBF",
        "protein_names_uniprotkb": "Progesterone-induced-blocking factor 1; CEP90; Centrosomal protein of 90 kDa; PIBF",
        "protein_names_refseq": "centrosomal protein of 90 kDa; progesterone-induced-blocking factor 1 isoform 2; progesterone-induced-blocking factor 1",
        "tax_id": 9606,
        "disease": "Joubert syndrome 33 (Disease Ontology:DOID:0080279)",
        "pathway": " (hsa:10464)",
        "pathway_count": 1,
        "publication_count": 62,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11407300;11935316;12516630;12733588;14634107;14654843;15269099;15305375;16393965;18452278;18817979;20112406;21224392;23110211;25218441;25576301;25645385;25880248;26154972;26167768;26297806;26538025;26992070;27846572;28228285;28904123;29557506;30315122;30429286;31217245;31530632;31844290;32157095;32161166;32265295;32350084;32357974;32387766;32938616;32983136;33141586;33298915;33691108;33912179;33936100;33968037;33981976;34241634;34357683;34509645;34554496;34932366;35051231;35251023;35561310;36010968;37182685;37938771;38374152;3863495",
        "class_list": "",
        "function": "A ciliopathy complex builds distal appendages to initiate ciliogenesis., [RefSeq, PubMed]; Biologia futura: embryo-maternal communication via progesterone-induced blocking factor (PIBF) positive embryo-derived extracellular vesicles. Their role in maternal immunomodulation. Review article, [RefSeq, PubMed]; PIBF1 regulates multiple gene expression via impeding long-range chromatin interaction to drive the malignant transformation of HPV16 integration epithelial cells., [RefSeq, PubMed]; PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. Publication Status: Online-Only, [RefSeq, PubMed]; Pericentriolar protein required to maintain mitotic spindle pole integrity (PubMed:21224392). Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation (PubMed:23110211). Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (PubMed:26297806)., [UniProtKB, PubMed, PubMed, PubMed]; Plays a role in ciliogenesis., [UniProtKB, PubMed]; The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual natural killer cells (NK) activity exerts an anti-abortive effect (PubMed:12516630, PubMed:14634107, PubMed:3863495). Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein (PubMed:16393965, PubMed:25218441)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a protein that is induced by the steroid hormone progesterone and plays a role in the maintenance of pregnancy. The encoded protein regulates multiple facets of the immune system to promote normal pregnancy including cytokine synthesis, natural killer (NK) cell activity, and arachidonic acid metabolism. Low serum levels of this protein have been associated with spontaneous pre-term labor in humans. This protein may promote the proliferation, migration and invasion of glioma. [provided by RefSeq, Mar 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 9835,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O95664;Q6U9V2;Q6UG50;Q86V07;Q96SF4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005136 interleukin-4 receptor binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005815 microtubule organizing center",
        "go_biological_process": "GO:0031393 negative regulation of prostaglandin biosynthetic process;GO:0090307 mitotic spindle assembly;GO:0060271 cilium assembly;GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein;GO:0007080 mitotic metaphase chromosome alignment",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "Q8WXW3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NRY2-1",
        "uniprot_id": "SOSSC_HUMAN",
        "mass": 11425.0,
        "length": 104,
        "protein_name": "SOSS complex subunit C",
        "gene_name": "INIP",
        "organism": "Human",
        "refseq_name": "SOSS complex subunit C isoform a",
        "refseq_ac": "NP_067041",
        "gene_names_uniprotkb": "INIP; C9orf80; HSPC043; HSPC291; SSBIP1",
        "gene_names_refseq": "C9orf80; HSPC043; INIP; MISE; SOSSC; SSBIP1; hSSBIP1",
        "protein_names_uniprotkb": "SOSS complex subunit C; INTS3- and NABP-interacting protein; SOSS-C; SSB-interacting protein 1; Sensor of single-strand DNA complex subunit C; Sensor of ssDNA subunit C; Single-stranded DNA-binding protein-interacting protein 1; hSSBIP1",
        "protein_names_refseq": "SOSS complex subunit C isoform a; SOSS complex subunit C; SSB-interacting protein 1; hSSB-interacting protein 1; minute INTS3/hSSB-associated element; sensor of single-strand DNA complex subunit C; sensor of ssDNA subunit C; single-stranded DNA-binding protein-interacting protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:58493)",
        "pathway_count": 1,
        "publication_count": 30,
        "publication_id_list": "11237011;19605351;19683501;19786574;23186163;23481700;24714562;25576301;26728094;27397612;27893789;29150435;29557506;31844290;32350084;32387766;32488085;32983136;33141586;33392160;33968037;34357683;34509645;34932366;35251023;36215666;36241641;37217939;37938771;39894887",
        "class_list": "",
        "function": "Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; HSSBIP1 forms complexes with INTS3/hSSB1 and INTS3/hSSB2 and participates in the DNA damage response, [RefSeq, PubMed]; INTS3, but not C9ORF80, affects the nucleic acid-binding ability of hNABP1 and hNABP2, indicating that INTS3 might regulate hNABP1/hNABP2 biological function, while the role of C9ORF80 remains unknown. Publication Status: Online-Only, [RefSeq, PubMed]; MISE is part of the INTS3/MISE/hSSB1 (IMS1) complex, which controls the DNA damage response, [RefSeq, PubMed]; SOSS-C is part of an ssDNA-binding heterotrimeric complex, SOSS which is involved in the maintenance of genome stability., [RefSeq, PubMed]; The protein encoded by this gene is a subunit of single-stranded DNA binding complexes that are important for maintaining genome stability. These complexes are involved in G2/M checkpoint control and homologous recombination repair. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VWJ7;Q96E04;Q9P090",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break;GO:0070876 SOSS complex",
        "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0010212 response to ionizing radiation;GO:0000724 double-strand break repair via homologous recombination;GO:0044818 mitotic G2/M transition checkpoint",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q9NRY2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5HYN5-1",
        "uniprot_id": "CT451_HUMAN",
        "mass": 21273.0,
        "length": 189,
        "protein_name": "Cancer/testis antigen family 45 member A1",
        "gene_name": "CT45A1",
        "organism": "Human",
        "refseq_name": "cancer/testis antigen family 45 member A1",
        "refseq_ac": "NP_001017417",
        "gene_names_uniprotkb": "CT45A1; CT45-1",
        "gene_names_refseq": "CT45-1; CT45.1; CT45A1; CT45",
        "protein_names_uniprotkb": "Cancer/testis antigen family 45 member A1; Cancer/testis antigen 45-1; Cancer/testis antigen 45A1",
        "protein_names_refseq": "cancer/testis antigen 45-1; cancer/testis antigen 45A1; cancer/testis antigen CT45-1; cancer/testis antigen family 45 member A1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:541466)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "15905330;19296537;20133697;24190977;24901056;26098711;31429579;32938616;33602962;34172717;34503444;37924456",
        "class_list": "",
        "function": "CT45A1 functions as a novel proto-oncogene to trigger oncogenesis and metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; CT45A1 promotes the metastasis of osteosarcoma cells in vitro and in vivo through beta-catenin. Publication Status: Online-Only, [RefSeq, PubMed]; Cancer/testis-45A1 promotes cervical cancer cell tumorigenesis and drug resistance by activating oncogenic SRC and downstream signaling pathways., [RefSeq, PubMed]; Hodgkin lymphoma has the highest CT45 expression among all malignancies tested, in diffuse large B-cell lymphomas it is similar to that seen in epithelial cancers, and not present in low-grade non-Hodgkin B-cell lymphomas., [RefSeq, PubMed]; Over-expression of CT45 is associated with cancer., [RefSeq, PubMed]; These data verify CT45 expression and promoter hypomethylation as possible prognostic biomarkers, and suggest CT45 as an immunological or therapeutic target in Epithelial ovarian cancer, [RefSeq, PubMed]; Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway. Publication Status: Online-Only, [RefSeq, PubMed]; YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EIR8",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q5HYN5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P60002-1",
        "uniprot_id": "ELOF1_HUMAN",
        "mass": 9462.0,
        "length": 83,
        "protein_name": "Transcription elongation factor 1 homolog",
        "gene_name": "ELOF1",
        "organism": "Human",
        "refseq_name": "transcription elongation factor 1 homolog",
        "refseq_ac": "NP_115753",
        "gene_names_uniprotkb": "ELOF1",
        "gene_names_refseq": "ELF1; ELOF1",
        "protein_names_uniprotkb": "Transcription elongation factor 1 homolog",
        "protein_names_refseq": "ELF1 homolog, elongation factor 1; elongation factor 1 homolog (ELF1, S. cerevisiae); transcription elongation factor 1 homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84337)",
        "pathway_count": 1,
        "publication_count": 29,
        "publication_id_list": "11237011;25576301;28832583;29242379;29508533;29557506;29786170;30779550;30833945;31154438;31222486;32157095;32502341;32897882;32983136;33717175;33912179;33981976;34087483;34108662;34108663;34171305;34932366;35051231;35318648;35561310;35580925;36241641;38316879",
        "class_list": "",
        "function": "ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation., [RefSeq, PubMed]; Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability. Erratum:[Nat Cell Biol. 2021 Jul;23(7):809. doi: 10.1038/s41556-021-00720-y. PMID: 34163038], [RefSeq, PubMed]; Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes (PubMed:34108662, PubMed:34108663, PubMed:38316879). Acts as a key adapter required to anchor TC-NER factors to RNA polymerase II: stably positions UVSSA and the DCX(ERCC8) complex (also named CSA complex) on arrested RNA polymerase II, leading to neddylation and activation of the DCX(ERCC8) complex and ubiquitination of RNA polymerase II (PubMed:38316879)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8R1J7;Q96II4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0000993 RNA polymerase II complex binding;GO:0046872 metal ion binding;GO:0003746 translation elongation factor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0008023 transcription elongation factor complex;GO:0005694 chromosome",
        "go_biological_process": "GO:0006368 transcription elongation by RNA polymerase II;GO:0006283 transcription-coupled nucleotide-excision repair",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "P60002-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13347-1",
        "uniprot_id": "EIF3I_HUMAN",
        "mass": 36502.0,
        "length": 325,
        "protein_name": "Eukaryotic translation initiation factor 3 subunit I",
        "gene_name": "EIF3I",
        "organism": "Human",
        "refseq_name": "eukaryotic translation initiation factor 3 subunit I isoform 1",
        "refseq_ac": "NP_003748",
        "gene_names_uniprotkb": "EIF3I; EIF3S2; TRIP1",
        "gene_names_refseq": "EIF3I; EIF3S2; PRO2242; TRIP-1; TRIP1; eIF3-beta; eIF3-p36",
        "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit I; Eukaryotic translation initiation factor 3 subunit 2; TGF-beta receptor-interacting protein 1; TRIP-1; eIF-3-beta; eIF3 p36; eIF3i",
        "protein_names_refseq": "TGF-beta receptor-interacting protein 1; TGFbeta receptor-interacting protein 1; eukaryotic translation initiation factor 3 subunit 2; eukaryotic translation initiation factor 3 subunit I isoform 1; eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD); eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa; predicted protein of HQ2242",
        "tax_id": 9606,
        "disease": "proprotein convertase 1/3 deficiency (Disease Ontology:DOID:0111698); hypothyroidism (Disease Ontology:DOID:1459); islet cell tumor (Disease Ontology:DOID:1799); endocrine system disease (Disease Ontology:DOID:28); hyperglycemia (Disease Ontology:DOID:4195); hyperthyroidism (Disease Ontology:DOID:7998); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:8668);  (R-HSA-156827);  (R-HSA-72649);  (R-HSA-72689);  (R-HSA-72695);  (R-HSA-72702);  (R-HSA-72706)",
        "pathway_count": 7,
        "publication_count": 147,
        "publication_id_list": "10364207;10659855;1095581;11018020;1104615;11237011;12493757;12588972;14519125;14567916;14688252;15592455;15703437;16322461;16766523;17322308;17581632;18083107;1856230;18599441;18991276;19608861;20068231;20305658;22645359;23186163;23481700;23783831;24366607;24397554;24714562;25418920;25576301;25645385;25810538;25849773;25880248;26024233;26154972;26375851;26728094;26811146;26992070;27090790;27462815;27600516;27846572;27920218;28218747;28228285;28446606;28510447;28514659;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;29930882;30315122;30410026;30429286;30524438;30573663;30779550;30833945;31154438;31217245;31222486;31530632;31844290;31848261;31998317;32119511;32157095;32161166;32265295;32350084;32357974;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33214551;33298915;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34087483;34171305;34185709;34229054;34357683;34561969;34725712;34932366;35008409;35051231;35138101;35318648;35561310;35580925;36010968;36241641;36284347;36580660;36979349;37611825;37689715;37938771;38374407;38665916;40914422;429297;592398;592399;641056;6853548;6901506;7000367;7566156;8943342;8995409;9045610;9732867;9857202",
        "class_list": "",
        "function": "CircEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-beta signalling pathway-mediated activation of MMPs in pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)., [UniProtKB, PubMed, HAMAP, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; EIF3i promotes colorectal cancer cell survival via augmenting PHGDH translation., [RefSeq, PubMed]; Insights into the Structure and Function of TRIP-1, a Newly Identified Member in Calcified Tissues. Publication Status: Online-Only, [RefSeq, PubMed]; METTL3-mediated m[6]A modification of lncRNA TSPAN12 promotes metastasis of hepatocellular carcinoma through SENP1-depentent deSUMOylation of EIF3I., [RefSeq, PubMed]; VALIDATED REFSEQ: This record has undergone validation or preliminary review. This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from AL049795.21 and AL121991.50., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0045202 synapse;GO:0070062 extracellular exosome;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex",
        "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex",
        "synthesized_glycan_count": 0,
        "hit_score": 15.0,
        "record_id": "Q13347-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q15599-1",
        "uniprot_id": "NHRF2_HUMAN",
        "mass": 37414.0,
        "length": 337,
        "protein_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF2",
        "gene_name": "NHERF2",
        "organism": "Human",
        "refseq_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform a",
        "refseq_ac": "NP_001123484",
        "gene_names_uniprotkb": "NHERF2; SLC9A3R2",
        "gene_names_refseq": "E3KARP; NHE3RF2; NHERF-2; NHERF2; OCTS2; SIP-1; SIP1; SLC9A3R2; TKA-1",
        "protein_names_uniprotkb": "Na(+)/H(+) exchange regulatory cofactor NHE-RF2; NHE3 kinase A regulatory protein E3KARP; NHERF-2; SIP-1; SRY-interacting protein 1; Sodium-hydrogen exchanger regulatory factor 2; Solute carrier family 9 isoform A3 regulatory factor 2; TKA-1; Tyrosine kinase activator protein 1",
        "protein_names_refseq": "NHE3 kinase A regulatory protein E3KARP; NHE3 regulatory factor 2; Na(+)/H(+) exchange regulatory cofactor 2; Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform a; Na(+)/H(+) exchange regulatory cofactor NHE-RF2; SLC9A3 regulator 2; SRY-interacting protein 1; sodium/hydrogen exchanger 3 kinase A regulatory protein; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2; tyrosine kinase activator protein 1",
        "tax_id": 9606,
        "disease": "hypophosphatemic nephrolithiasis/osteoporosis 2 (Disease Ontology:DOID:0080078); hypertension (Disease Ontology:DOID:10763)",
        "pathway": " (hsa:9351)",
        "pathway_count": 1,
        "publication_count": 46,
        "publication_id_list": "10455146;11237011;12444019;14623317;15143197;15642748;16615918;18669648;18829453;19555689;23186163;24275569;25576301;26310448;26992070;28510447;28514659;28834231;29557506;30429286;30524438;31154438;31848261;32157095;32350084;32387766;32488085;32897882;32938616;33592498;33968037;33981976;34019948;34087483;34171305;34509645;35051231;35251023;35318648;35580925;36010968;9054412;9096337;9314537;9671706;9831664",
        "class_list": "",
        "function": "Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DU84;D3DU85;H3BSV6;O00272;O00556;Q3KQY7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031800 type 3 metabotropic glutamate receptor binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0070062 extracellular exosome;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0065003 protein-containing complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "Q15599-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NPJ4-1",
        "uniprot_id": "PNRC2_HUMAN",
        "mass": 15591.0,
        "length": 139,
        "protein_name": "Proline-rich nuclear receptor coactivator 2",
        "gene_name": "PNRC2",
        "organism": "Human",
        "refseq_name": "proline-rich nuclear receptor coactivator 2",
        "refseq_ac": "NP_060231",
        "gene_names_uniprotkb": "PNRC2; HSPC208",
        "gene_names_refseq": "PNRC2",
        "protein_names_uniprotkb": "Proline-rich nuclear receptor coactivator 2",
        "protein_names_refseq": "proline-rich nuclear receptor coactivator 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55629);  (R-HSA-975957)",
        "pathway_count": 2,
        "publication_count": 72,
        "publication_id_list": "11237011;11331269;11532962;11544179;11546874;11551508;11574675;12417715;12554878;12718880;12832468;14527413;14636577;14651967;14742663;14973490;15034551;15546618;15721257;16186820;16209946;16284618;16452507;16601204;17053788;17352659;17363904;17803942;17893241;18066079;18256688;18423202;18524595;18657639;18974281;19060897;19150429;19359157;19417104;19478851;19503078;19556969;19859661;19909264;20023408;20479275;20691628;20817927;20930030;21145460;21419344;23085078;23234702;25576301;25775514;25892735;26154972;26992070;28218747;28228285;29242379;29348139;29437277;29557506;29632711;29769354;30410026;30429286;31844290;31848261;32157095;33912179",
        "class_list": "",
        "function": "Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Not only PNRC2 but also the corepressor TLE1 functioned as ERRgamma coactivator in a reporter gene analysis., [RefSeq, PubMed]; PNRC2 acts in synergy with Dcp1a to stimulate the decapping activity of Dcp2 by bridging the interaction between Dcp1a and Dcp2., [RefSeq, PubMed]; PNRC2 plays an essential role in mammalian Nonsense-mediated mRNA decay (NMD), mediating the interaction between the NMD machinery and the decapping complex., [RefSeq, PubMed]; UPF1 interacts with PNRC2 and that it triggers 5'-3' exonucleolytic decay of reporter transcripts in tethering assays. PNRC2 is probably an important mRNA decapping factor but that it does not appear to be required for nonsense-mediated mRNA decay., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DU72",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000932 P-body",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA",
        "synthesized_glycan_count": 0,
        "hit_score": 7.3,
        "record_id": "Q9NPJ4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96RN1-1",
        "uniprot_id": "S26A8_HUMAN",
        "mass": 109006.0,
        "length": 970,
        "protein_name": "Testis anion transporter 1",
        "gene_name": "SLC26A8",
        "organism": "Human",
        "refseq_name": "testis anion transporter 1 isoform a",
        "refseq_ac": "NP_001180405",
        "gene_names_uniprotkb": "SLC26A8; TAT1",
        "gene_names_refseq": "AZON; SLC26A8; SPGF3; TAT1",
        "protein_names_uniprotkb": "Testis anion transporter 1; Anion exchange transporter; Solute carrier family 26 member 8",
        "protein_names_refseq": "anion transporter/exchanger-8; solute carrier family 26 (anion exchanger), member 8; testis anion transporter 1 isoform a; testis anion transporter 1",
        "tax_id": 9606,
        "disease": "spermatogenic failure 3 (Disease Ontology:DOID:0070168)",
        "pathway": " (hsa:116369)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11278976;11834742;15579655;17517695;18452278;22121115;23481700;23582645;24715725;25645385;29557506;30484775;32387766;32938616;33392160;34509645;34923715;35051231;35181959;37217939;39894887",
        "class_list": "glycogene",
        "function": "Antiporter that mediates the exchange of sulfate and oxalate against chloride ions across a membrane (PubMed:11278976, PubMed:11834742). Stimulates anion transport activity of CFTR (PubMed:22121115, PubMed:23582645). May cooperate with CFTR in the regulation of chloride and bicarbonate ions fluxes required for activation of the ADCY10/PKA pathway during sperm motility and sperm capacitation (By similarity). May play a role in sperm tail differentiation and motility and hence male fertility (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia., [RefSeq, PubMed]; Novel biallelic mutations in SLC26A8 cause severe asthenozoospermia in humans owing to midpiece defects: Insights into a putative dominant genetic disease., [RefSeq, PubMed]; SLC26A8 mutations are not a common cause of male infertility. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The heterozygous mutations of SLC26A8 are not the main actors for male infertility., [RefSeq, PubMed]; This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 1112,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5JVR5;Q812C7;Q8TC65;Q96MA0;Q96PK8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005254 chloride channel activity;GO:0019531 oxalate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity;GO:0140900 chloride:bicarbonate antiporter activity;GO:0160044 sulfate:chloride antiporter activity",
        "go_cellular_component": "GO:0097227 sperm annulus;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0019532 oxalate transport;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q96RN1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IWB6-1",
        "uniprot_id": "TEX14_HUMAN",
        "mass": 167901.0,
        "length": 1497,
        "protein_name": "Inactive serine/threonine-protein kinase TEX14",
        "gene_name": "TEX14",
        "organism": "Human",
        "refseq_name": "inactive serine/threonine-protein kinase TEX14 isoform c",
        "refseq_ac": "NP_001188386",
        "gene_names_uniprotkb": "TEX14; SGK307",
        "gene_names_refseq": "CT113; SPGF23; SgK307; TEX14",
        "protein_names_uniprotkb": "Inactive serine/threonine-protein kinase TEX14; Protein kinase-like protein SgK307; Sugen kinase 307; Testis-expressed sequence 14 protein; Testis-expressed sequence 14",
        "protein_names_refseq": "cancer/testis antigen 113; inactive serine/threonine-protein kinase TEX14 isoform c; inactive serine/threonine-protein kinase TEX14; protein kinase-like protein SgK307; sugen kinase 307; testis-expressed protein 14; testis-expressed sequence 14 protein",
        "tax_id": 9606,
        "disease": "spermatogenic failure 23 (Disease Ontology:DOID:0070181)",
        "pathway": " (hsa:56155)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "11237011;11279525;12471243;12711554;17344846;20056645;20176808;22405274;28206990;28228285;29557506;30379171;32157095;32741963;33141586;33728612;34561969;35051231;36215666;37409705",
        "class_list": "",
        "function": "Inhibition mechanism of testis-expressed gene 14 (TEX14) in cytokinetic abscission: Well-tempered metadynamics simulation studies., [RefSeq, PubMed]; Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator), [RefSeq, PubMed]; Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity)., [UniProtKB]; TEX14 is specifically expressed in testis, [RefSeq, PubMed]; TEX14, also known as SgK307, contains a variant and probably inactive protein kinase domain and N-terminal ankyrin repeats. Review article, [RefSeq, PubMed]; Targeted next-generation sequencing panel screening of 668 Chinese patients with non-obstructive azoospermia., [RefSeq, PubMed]; The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NH19;Q7RTP3;Q8ND97;Q9BXT9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0070062 extracellular exosome;GO:0045171 intercellular bridge;GO:0000776 kinetochore;GO:0030496 midbody",
        "go_biological_process": "GO:0043063 intercellular bridge organization;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0051306 mitotic sister chromatid separation;GO:0007094 mitotic spindle assembly checkpoint signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q8IWB6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6RSH7-1",
        "uniprot_id": "VHLL_HUMAN",
        "mass": 15781.0,
        "length": 139,
        "protein_name": "von Hippel-Lindau-like protein",
        "gene_name": "VHLL",
        "organism": "Human",
        "refseq_name": "von Hippel-Lindau-like protein",
        "refseq_ac": "NP_001004319",
        "gene_names_uniprotkb": "VHLL; VLP",
        "gene_names_refseq": "VHLL; VHLP; VLP",
        "protein_names_uniprotkb": "von Hippel-Lindau-like protein; VHL-like protein; VLP",
        "protein_names_refseq": "VHL pseudogene; VHL-like protein; von Hippel-Lindau tumor suppressor like; von Hippel-Lindau-like protein",
        "tax_id": 9606,
        "disease": "familial erythrocytosis 2 (Disease Ontology:DOID:0060474); von Hippel-Lindau disease (Disease Ontology:DOID:14175); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)",
        "pathway": " (hsa:391104)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "14757845;20934997;31485743",
        "class_list": "",
        "function": "Functions as a dominant-negative VHL to serve as a protector of HIFalpha., [UniProtKB, PubMed]; Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha. [provided by RefSeq, Jan 2010]., [RefSeq]; Von Hippel-Lindau-like protein (VLP) is conserved in upper mammals and specifically expressed in brain and testis. Structural analysis and molecular dynamics simulations show VLP to be similar to von Hippel-Lindau tumor suppressor protein (pVHL) three-dimensional organization and binding dynamics. Conservation of elements at the protein interfaces suggests VLP to be a functional pVHL homolog possessing multiple functions., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L4M4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q6RSH7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15062-1",
        "uniprot_id": "ZBTB5_HUMAN",
        "mass": 74278.0,
        "length": 677,
        "protein_name": "Zinc finger and BTB domain-containing protein 5",
        "gene_name": "ZBTB5",
        "organism": "Human",
        "refseq_name": "zinc finger and BTB domain-containing protein 5",
        "refseq_ac": "NP_055687",
        "gene_names_uniprotkb": "ZBTB5; KIAA0354",
        "gene_names_refseq": "ZBTB5",
        "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 5",
        "protein_names_refseq": "zinc finger and BTB domain-containing protein 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9925)",
        "pathway_count": 1,
        "publication_count": 36,
        "publication_id_list": "19491398;19690332;23186163;24714562;25418920;25576301;25755297;26375851;26728094;26992070;27846572;27920218;28063628;28832583;28834231;28904123;29393594;29632046;30833945;31530632;31844290;32265295;32357974;32387766;32502341;32897882;32938616;32983136;33051058;33912179;33968037;34171305;35051231;35580925;36010968;37938771",
        "class_list": "",
        "function": "Cell fate decisions by c-Myc depend on ZBTB5 and p53., [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB]; ZBTB5 directly repressed transcription of cell cycle arrest gene p21 by binding to the proximal GC-box 5/6 elements and the two distal p53-responsive elements (bp -2323 to -2299; bp -1416 to -1392), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "O15062-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TAQ2-1",
        "uniprot_id": "SMRC2_HUMAN",
        "mass": 132879.0,
        "length": 1214,
        "protein_name": "SWI/SNF complex subunit SMARCC2",
        "gene_name": "SMARCC2",
        "organism": "Human",
        "refseq_name": "SWI/SNF complex subunit SMARCC2 isoform c",
        "refseq_ac": "NP_001123892",
        "gene_names_uniprotkb": "SMARCC2; BAF170",
        "gene_names_refseq": "BAF170; CRACC2; CSS8; Rsc8; SMARCC2",
        "protein_names_uniprotkb": "SWI/SNF complex subunit SMARCC2; BAF170; BRG1-associated factor 170; SWI/SNF complex 170 kDa subunit; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2",
        "protein_names_refseq": "SWI/SNF complex 170 kDa subunit; SWI/SNF complex subunit SMARCC2 isoform c; SWI/SNF complex subunit SMARCC2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2; SWI3-like protein; chromatin remodeling complex BAF170 subunit; mammalian chromatin remodeling complex BRG1-associated factor 170",
        "tax_id": 9606,
        "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340); Coffin-Siris syndrome 8 (Disease Ontology:DOID:0112367); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); Coffin-Siris syndrome (Disease Ontology:DOID:1925)",
        "pathway": " (hsa:6601);  (R-HSA-3214858);  (R-HSA-8939243);  (R-HSA-9824585);  (R-HSA-9845323);  (R-HSA-9933939);  (R-HSA-9933946);  (R-HSA-9933947);  (R-HSA-9934037)",
        "pathway_count": 9,
        "publication_count": 193,
        "publication_id_list": "10078207;10587587;11018012;11237011;11238380;11341840;11448779;11532965;11747826;11751582;11756452;11856727;11964381;12062444;12192000;12368262;12917342;1321344;15302935;1537333;1537334;15485929;15543135;15640446;15695812;15729346;15985610;16265664;16303920;16917507;17081983;17182843;17215844;17322306;17498659;17640523;17898714;17924679;17952075;18079182;18404153;18452278;18483556;18669648;18695000;18697795;18707149;18765789;18809673;18812475;19007248;19234465;19389701;19413330;19525936;19608861;19651622;19664994;19664995;19690332;19691289;19717472;20058876;20068231;20166139;20506188;20951943;21316606;21406692;21555454;21740066;21774791;22121020;22231400;22325351;22424782;22464331;22952240;23186163;23481700;23644491;23785148;24267888;24275569;24366607;24714562;24715725;24874740;25418920;25576301;25645385;25755297;25772364;25892735;26154972;26365797;26375851;26601204;26694611;26728094;26811146;26992070;27600516;27655845;27846572;27862975;27920218;28218747;28228285;28533407;28832583;28834231;28904123;29242379;29374058;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30410026;30429286;30484775;30515787;30524438;30580808;30833945;31092671;31154438;31217245;31222486;31530632;31844290;31848261;31998317;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33100333;33141586;33214551;33298915;33392160;33592498;33912179;33936100;33968037;33981976;34019948;34105348;34171305;34465901;34509645;34725712;34932366;35051231;35138101;35154160;35251023;35580127;35580925;36010968;36215666;36241641;36284347;36418306;37348029;37551667;37938771;38359823;38665916;39531497;40914422;7813420;8306979;8804307;8921401;9642256;9758418",
        "class_list": "",
        "function": "Elucidating the clinical and molecular spectrum of SMARCC2-associated NDD in a cohort of 65 affected individuals., [RefSeq, PubMed]; FBXO28 promotes proliferation, invasion, and metastasis of pancreatic cancer cells through regulation of SMARCC2 ubiquitination. Erratum:[Aging (Albany NY). 2023 Sep 14;15(17):9230-9232. doi: 10.18632/aging.205071. PMID: 37708091], [RefSeq, PubMed]; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; SMARCC2 mediates the regulation of DKK1 by the transcription factor EGR1 through chromatin remodeling to reduce the proliferative capacity of glioblastoma. Erratum:[Cell Death Dis. 2022 Dec 12;13(12):1033. doi: 10.1038/s41419-022-05498-x. PMID: 36509739] Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 4,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 22,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F8VTJ5;Q59GV3;Q92923;Q96E12;Q96GY4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042393 histone binding;GO:0003682 chromatin binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0071564 npBAF complex;GO:0016363 nuclear matrix;GO:0071565 nBAF complex",
        "go_biological_process": "GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 19.7,
        "record_id": "Q8TAQ2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96JQ5-1",
        "uniprot_id": "M4A4A_HUMAN",
        "mass": 25441.0,
        "length": 239,
        "protein_name": "Membrane-spanning 4-domains subfamily A member 4A",
        "gene_name": "MS4A4A",
        "organism": "Human",
        "refseq_name": "membrane-spanning 4-domains subfamily A member 4A isoform 3",
        "refseq_ac": "NP_001230195",
        "gene_names_uniprotkb": "MS4A4A; 4SPAN1; CD20L1; HDCME31P; MS4A4",
        "gene_names_refseq": "4SPAN1; CD20-L1; CD20L1; HDCME31P; MS4A4A; MS4A4; MS4A7",
        "protein_names_uniprotkb": "Membrane-spanning 4-domains subfamily A member 4A; CD20 antigen-like 1; Four-span transmembrane protein 1",
        "protein_names_refseq": "CD20 antigen-like 1; Fc epsilon receptor beta subunit homolog; epididymis secretory sperm binding protein; four-span transmembrane protein 1; membrane-spanning 4-domains subfamily A member 4A isoform 3; membrane-spanning 4-domains subfamily A member 4A; membrane-spanning 4-domains, subfamily A, member 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51338)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "11237011;11245982;11401424;11486273;21460841;23573206;29557506;31154438;31263276;31848261;32240745;32387766;33043033;33123756;35051231;35251023;35580925",
        "class_list": "",
        "function": "Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease., [RefSeq, PubMed]; MS4A4A is a tetraspan molecule selectively expressed in macrophages during differentiation and polarization, essential for dectin-1-dependent activation of natural killer cell-mediated resistance to metastasis., [RefSeq, PubMed]; May be involved in signal transduction as a component of a multimeric receptor complex., [UniProtKB]; Single nucleotide polymorphisms in APOE-epsilon4, CLU and MS4A4A influence both Alzheimer disease risk and cerebrospinal fluid Amyloid-beta1-42 levels., [RefSeq, PubMed]; The FcepsilonRIbeta homologue, MS4A4A, promotes FcepsilonRI signal transduction and store-operated Ca(2+) entry in human mast cells., [RefSeq, PubMed]; This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features, similar intron/exon splice boundaries, and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8TEZ6;Q96PG7;Q9BY18;Q9H3V3;Q9P1S3",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0044853 plasma membrane raft;GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q96JQ5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UH03-1",
        "uniprot_id": "SEPT3_HUMAN",
        "mass": 40704.0,
        "length": 358,
        "protein_name": "Neuronal-specific septin-3",
        "gene_name": "SEPTIN3",
        "organism": "Human",
        "refseq_name": "neuronal-specific septin-3 isoform B",
        "refseq_ac": "NP_061979",
        "gene_names_uniprotkb": "SEPTIN3; SEP3; SEPT3",
        "gene_names_refseq": "SEP3; SEPT3; SEPTIN3; bK250D10.3",
        "protein_names_uniprotkb": "Neuronal-specific septin-3",
        "protein_names_refseq": "neuronal-specific septin-3 isoform B; neuronal-specific septin-3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55964)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "11237011;11322766;15107017;15200238;15915442;18477386;23163726;23481700;26992070;29557506;30410026;31844290;32157095;32938616;32983136;33912179;33968037;35051231;35580925;36010968",
        "class_list": "",
        "function": "Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)., [UniProtKB]; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis., [UniProtKB, UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene belongs to the septin family of GTPases. Members of this family are required for cytokinesis. Expression is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not been determined. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, May 2018]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AHR0;Q2NKJ7;Q59GF7;Q6IBZ6;Q8N3P3;Q9HD35",
        "ec_number_list": "",
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005940 septin ring;GO:0015630 microtubule cytoskeleton;GO:0098793 presynapse;GO:0031105 septin complex;GO:0032153 cell division site",
        "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q9UH03-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y371-1",
        "uniprot_id": "SHLB1_HUMAN",
        "mass": 40796.0,
        "length": 365,
        "protein_name": "Endophilin-B1",
        "gene_name": "SH3GLB1",
        "organism": "Human",
        "refseq_name": "endophilin-B1 isoform 3",
        "refseq_ac": "NP_001193581",
        "gene_names_uniprotkb": "SH3GLB1; CGI-61; KIAA0491",
        "gene_names_refseq": "Bif-1; CGI-61; PPP1R70; SH3GLB1; dJ612B15.2",
        "protein_names_uniprotkb": "Endophilin-B1; Bax-interacting factor 1; Bif-1; SH3 domain-containing GRB2-like protein B1",
        "protein_names_refseq": "Bax-interacting factor 1; SH3 domain-containing GRB2-like protein B1; SH3-containing protein SH3GLB1; SH3-domain GRB2 like endophilin B1; endophilin-B1 isoform 3; protein phosphatase 1, regulatory subunit 70; testicular tissue protein Li 172",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51100)",
        "pathway_count": 1,
        "publication_count": 76,
        "publication_id_list": "10.1101/2023.09.13.557529;11161816;11237011;11259440;11604418;12456676;15452144;16227588;17891140;20068231;20643123;21068542;21499257;23301498;25418920;25576301;25645385;25880248;26154972;26811146;26992070;27846572;27920218;28063628;28228285;28832583;28834231;28904123;29242379;29331515;29393594;29557506;29632046;30315122;30429286;30779550;30833945;31154438;31844290;31848261;31998317;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33123756;33298915;33592498;33691108;33912179;33968037;33981976;34019948;34087483;34357683;34405274;34432728;34509645;34561969;34725712;34932366;35051231;35154160;35580925;36010968;36284347;37938771;38665916;40914422",
        "class_list": "",
        "function": "Double knockdown of endophilin B1 and Drp1 leads to a mitochondrial phenotype identical to that of the Drp1 single knockdown, a result consistent with Drp1 acting upstream of endophilin B1 in the maintenance of morphological dynamics of mitochondria., [RefSeq, PubMed]; May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E182;Q5H8U5;Q9H3Z0;Q9NR47;Q9NYA9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005504 fatty acid binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0042803 protein homodimerization activity;GO:0045296 cadherin binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol",
        "go_biological_process": "GO:0006897 endocytosis;GO:1903955 positive regulation of protein targeting to mitochondrion;GO:0006915 apoptotic process;GO:0016241 regulation of macroautophagy;GO:0061024 membrane organization",
        "synthesized_glycan_count": 0,
        "hit_score": 8.1,
        "record_id": "Q9Y371-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9HBW0-1",
        "uniprot_id": "LPAR2_HUMAN",
        "mass": 38741.0,
        "length": 348,
        "protein_name": "Lysophosphatidic acid receptor 2",
        "gene_name": "LPAR2",
        "organism": "Human",
        "refseq_name": "lysophosphatidic acid receptor 2",
        "refseq_ac": "NP_001382589",
        "gene_names_uniprotkb": "LPAR2; EDG4; LPA2",
        "gene_names_refseq": "EDG-4; EDG4; LPA-2; LPA2; LPAR2",
        "protein_names_uniprotkb": "Lysophosphatidic acid receptor 2; LPA receptor 2; LPA-2; Lysophosphatidic acid receptor Edg-4",
        "protein_names_refseq": "G protein-coupled receptor; LPA receptor 2; LPA receptor EDG4; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4; lysophosphatidic acid receptor 2; lysophosphatidic acid receptor EDG4; lysophosphatidic acid receptor Edg-4",
        "tax_id": 9606,
        "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); spinal neurofibromatosis (Disease Ontology:DOID:0070482); Watson syndrome (Disease Ontology:DOID:0070483); colorectal carcinoma (Disease Ontology:DOID:0080199); neurofibromatosis 1 (Disease Ontology:DOID:0111253); neurofibromatosis-Noonan syndrome (Disease Ontology:DOID:0111683); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); sciatic neuropathy (Disease Ontology:DOID:11446); autistic disorder (Disease Ontology:DOID:12849); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); lung non-small cell carcinoma (Disease Ontology:DOID:3908); optic nerve glioma (Disease Ontology:DOID:4992); plexiform neurofibroma (Disease Ontology:DOID:5151); sleep disorder (Disease Ontology:DOID:535); neurofibromatosis (Disease Ontology:DOID:8712); acute myeloid leukemia (Disease Ontology:DOID:9119)",
        "pathway": " (hsa:9170);  (R-HSA-416476);  (R-HSA-418594);  (R-HSA-419408)",
        "pathway_count": 4,
        "publication_count": 69,
        "publication_id_list": "10191087;10488065;10488122;10567430;10617617;10727522;10727532;10729222;10753843;10799507;10861009;10922489;11007482;11015615;11093753;11237011;11742120;11753430;12120503;12427546;12730698;15143197;15951850;16182515;16268778;16339447;16634148;16754659;16904289;16923326;18434541;18515384;18577758;18936096;1905813;19306925;19366702;20061941;2160972;23388400;24900670;25002680;2534964;26990079;2748346;27920218;28063628;28228285;2834384;2841328;29632046;29735753;3086311;32265295;35241179;35799024;35857125;38986295;7937899;8015379;8406495;8626678;8664309;8878560;9070858;9305846;9525886;9770463;9804623",
        "class_list": "",
        "function": "Circ_0007611 modulates the miR-34c-5p/LPAR2 cascade to suppress proliferation and enhance apoptosis of HTR-8/SVneo cells., [RefSeq, PubMed]; Estrogen-increased SGK1 Promotes Endometrial Stromal Cell Invasion in Adenomyosis by Regulating with LPAR2., [RefSeq, PubMed]; LPAR2 correlated with different prognosis and immune cell infiltration in head and neck squamous cell carcinoma and kidney renal clear cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; LPAR2-mediated action promotes human renal cell carcinoma via MAPK/NF-kappaB signaling to regulate cytokine network., [RefSeq, PubMed]; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation., [UniProtKB, PubMed, PubMed]; This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 19,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O00543;O43431",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008289 lipid binding;GO:0030165 PDZ domain binding;GO:0070915 lysophosphatidic acid receptor activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q9HBW0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BY27-1",
        "uniprot_id": "DGC6L_HUMAN",
        "mass": 24932.0,
        "length": 220,
        "protein_name": "Protein DGCR6L",
        "gene_name": "DGCR6L",
        "organism": "Human",
        "refseq_name": "protein DGCR6L",
        "refseq_ac": "NP_150282",
        "gene_names_uniprotkb": "DGCR6L",
        "gene_names_refseq": "DGCR6L; DGCR6",
        "protein_names_uniprotkb": "Protein DGCR6L; DiGeorge syndrome critical region 6-like protein",
        "protein_names_refseq": "diGeorge syndrome critical region 6-like protein; protein DGCR6L",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:85359)",
        "pathway_count": 1,
        "publication_count": 28,
        "publication_id_list": "11157784;11237011;15821931;18477386;19778628;22832905;23481700;25576301;25645385;27543614;28832583;28904123;29242379;29485866;29786170;30379171;30429286;31844290;32157095;32161166;32938616;32983136;33592498;34087483;34171305;34211107;36010968;36241641",
        "class_list": "",
        "function": "DGCR6L, a novel PAK4 interacting protein, regulated PAK4-mediated migration of human gastric cancer cells via LIMK1., [RefSeq, PubMed]; Further studies are now needed to test the usefulness of DGCR6 and DGCR6L expression and alterations in the epigenome at these loci in predicting childhood anxiety and associated adult-onset pathologies in 22q11DS subjects. Erratum:[Transl Psychiatry. 2012;2:e124. Chakraborty, D [corrected to Das Chakraborty, R]] Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches., [UniProtKB]; This gene, the result of a duplication at this locus, is one of two functional genes encoding nearly identical proteins that have similar expression patterns. The product of this gene is a protein that shares homology with the Drosophila gonadal protein, expressed in gonadal tissues and germ cells, and with the human laminin gamma-1 chain that functions in cell attachment and migration. This gene is located in a region of chromosome 22 implicated in the DiGeorge syndrome, one facet of a broader collection of anomalies referred to as the CATCH 22 syndrome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K1N7;B3KMC0;D3DX29;Q9BW33",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "Q9BY27-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5SQN1-1",
        "uniprot_id": "SNP47_HUMAN",
        "mass": 52562.0,
        "length": 464,
        "protein_name": "Synaptosomal-associated protein 47",
        "gene_name": "SNAP47",
        "organism": "Human",
        "refseq_name": "synaptosomal-associated protein 47 isoform c",
        "refseq_ac": "NP_001310864",
        "gene_names_uniprotkb": "SNAP47; C1orf142; HEL170; SVAP1",
        "gene_names_refseq": "C1orf142; ESFI5812; HEL-S-290; HEL170; SNAP-47; SNAP47; SVAP1",
        "protein_names_uniprotkb": "Synaptosomal-associated protein 47; Epididymis luminal protein 170; SNAP-47; Synaptosomal-associated 47 kDa protein",
        "protein_names_refseq": "epididymis luminal protein 170; epididymis secretory protein Li 290; synaptosomal-associated 47 kDa protein; synaptosomal-associated protein 47 isoform c; synaptosomal-associated protein 47; synaptosomal-associated protein, 47kDa; synaptosome associated protein 47kDa",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:116841)",
        "pathway_count": 1,
        "publication_count": 37,
        "publication_id_list": "11237011;19546860;22373659;24715725;26992070;27846572;28228285;28467828;28657654;28832583;28834231;28904123;29242379;29485866;29557506;30315122;30484775;30524438;31844290;32157095;32387766;32488085;32502341;33141586;33298915;33592498;33936100;33968037;34087483;34171305;34440910;34509645;34932366;35900666;38182888;38253038;40307207",
        "class_list": "",
        "function": "A novel identified circular RNA, circSnap47, promotes heart failure progression via regulation of miR-223-3p/MAPK axis., [RefSeq, PubMed]; Plays a role in intracellular membrane fusion., [UniProtKB]; SNAP47 Interacts with ATG14 to Promote VP1 Conjugation and CVB3 Propagation. Publication Status: Online-Only, [RefSeq, PubMed]; The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion., [RefSeq, PubMed]; Three proteins are identified: PAI-RBP1, C1orf142, and COTL1, which are differentially expressed in non-small cell lung cancer cell lines with different metastatic potential., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B6EDE0;Q5HYB5;Q5TBZ3;Q8N558;Q8TB31;Q8TCW8;Q8WV46;Q96CQ3;Q96FE1;Q96I66;Q96NU3;Q9BT10;Q9BVB2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity",
        "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005765 lysosomal membrane;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0016236 macroautophagy;GO:0009267 cellular response to starvation;GO:0006887 exocytosis;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane;GO:0006906 vesicle fusion",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "Q5SQN1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N3F0-1",
        "uniprot_id": "MTURN_HUMAN",
        "mass": 14925.0,
        "length": 131,
        "protein_name": "Maturin",
        "gene_name": "MTURN",
        "organism": "Human",
        "refseq_name": "maturin",
        "refseq_ac": "NP_690006",
        "gene_names_uniprotkb": "MTURN; C7orf41",
        "gene_names_refseq": "C7orf41; Ells1; MTURN",
        "protein_names_uniprotkb": "Maturin; Maturin neural progenitor differentiation regulator protein homolog; Protein Ells1",
        "protein_names_refseq": "UPF0452 protein C7orf41; maturin neural progenitor differentiation regulator protein homolog; maturin; protein Ells1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:222166)",
        "pathway_count": 1,
        "publication_count": 30,
        "publication_id_list": "11237011;23301498;24681962;25576301;25892735;27600516;27846572;27862975;28832583;29242379;29493099;29508533;29557506;29632711;30429286;30779550;31154438;31222486;31552488;31844290;31848261;32157095;33506033;33528492;33592498;33691108;33981976;35580925;36241641;36284347",
        "class_list": "",
        "function": "C7ORF41 Regulates Inflammation by Inhibiting NF-kappaB Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; High MTURN expression is associated with lung cancer., [RefSeq, PubMed]; PKCalpha/ERK/C7ORF41 axis regulates epidermal keratinocyte differentiation through the IKKalpha nuclear translocation., [RefSeq, PubMed]; Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression (PubMed:24681962). Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser-536' (PubMed:24681962). May be involved in early neuronal development (By similarity)., [UniProtKB, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B8ZZW9;Q8N791;Q8N8M4;Q8NEX2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0045654 positive regulation of megakaryocyte differentiation;GO:0023051 regulation of signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q8N3F0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BS16-1",
        "uniprot_id": "CENPK_HUMAN",
        "mass": 31655.0,
        "length": 269,
        "protein_name": "Centromere protein K",
        "gene_name": "CENPK",
        "organism": "Human",
        "refseq_name": "centromere protein K isoform 1",
        "refseq_ac": "NP_001253967",
        "gene_names_uniprotkb": "CENPK; FKSG14; ICEN37",
        "gene_names_refseq": "AF5alpha; CENP-K; CENPK; FKSG14; P33; Solt",
        "protein_names_uniprotkb": "Centromere protein K; CENP-K; Interphase centromere complex protein 37; Protein AF-5alpha; p33",
        "protein_names_refseq": "SoxLZ/Sox6-binding protein Solt; centromere protein K isoform 1; interphase centromere complex protein 37; leucine zipper protein FKSG14; protein AF-5alpha",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64105);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-5663220);  (R-HSA-606279);  (R-HSA-68877);  (R-HSA-9648025)",
        "pathway_count": 9,
        "publication_count": 129,
        "publication_id_list": "10411507;10600384;10678165;10958683;11081627;11181178;11237011;11371342;11509732;11535616;11804586;12006501;12194817;12429848;12577064;12679384;12732141;12805219;12852857;14730319;15006353;15085137;15339662;15369671;15507212;15723797;15737063;15864301;15866170;15944396;16292343;16439214;16541025;16622419;16622420;16682347;16716197;16890222;16943183;17030981;17112726;17113138;17129783;17196341;17198702;17199038;17339379;1737036;18001770;18045986;18097444;18716626;18923426;19350017;19381461;19398759;19410544;19410545;19696148;19815554;19965387;20030946;20068231;20080577;20101212;20566683;20591975;21111234;21148482;21397845;21576392;21768289;21868368;21878504;21987589;22094460;22275430;22608513;22790947;22885700;23222643;23301498;23481700;23801653;24366607;24714562;24914801;25576301;25740311;25789526;26728094;26992070;27893789;27920218;28218747;28228285;28834231;28904123;29242379;29393594;29437277;31409757;31844290;32157095;32387766;32502341;32938616;32983136;33141586;33298915;33592498;33691108;33717175;33968037;34087483;34171305;34260926;34509645;34932366;35051231;35715658;36010968;36284347;36312839;38670220;8950979;9649308;9649503;9892021",
        "class_list": "",
        "function": "CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]., [RefSeq]; CENPK orchestrates ovarian cancer progression via GOLPH3-Mediated activation of mTOR signaling., [RefSeq, PubMed]; Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5., [RefSeq, PubMed]; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore., [UniProtKB, PubMed, PubMed, PubMed]; Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9H4L0",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000776 kinetochore;GO:0000775 chromosome, centromeric region",
        "go_biological_process": "GO:0051382 kinetochore assembly;GO:0007059 chromosome segregation;GO:0000070 mitotic sister chromatid segregation",
        "synthesized_glycan_count": 0,
        "hit_score": 13.2,
        "record_id": "Q9BS16-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q15561-1",
        "uniprot_id": "TEAD4_HUMAN",
        "mass": 48329.0,
        "length": 434,
        "protein_name": "Transcriptional enhancer factor TEF-3",
        "gene_name": "TEAD4",
        "organism": "Human",
        "refseq_name": "transcriptional enhancer factor TEF-3 isoform 1",
        "refseq_ac": "NP_003204",
        "gene_names_uniprotkb": "TEAD4; RTEF1; TCF13L1; TEF3",
        "gene_names_refseq": "EFTR-2; RTEF1; TCF13L1; TEAD4; TEF-3; TEF3; TEFR-1; hRTEF-1B",
        "protein_names_uniprotkb": "Transcriptional enhancer factor TEF-3; TEA domain family member 4; TEAD-4; Transcription factor 13-like 1; Transcription factor RTEF-1",
        "protein_names_refseq": "TEA domain family member 4; related transcription enhancer factor 1B; transcription factor 13-like 1; transcription factor RTEF-1; transcriptional enhancer factor 1-related; transcriptional enhancer factor 3; transcriptional enhancer factor TEF-3 isoform 1; transcriptional enhancer factor TEF-3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7004);  (R-HSA-2032785);  (R-HSA-8951671);  (R-HSA-9796292);  (R-HSA-9819196);  (R-HSA-9909649)",
        "pathway_count": 6,
        "publication_count": 65,
        "publication_id_list": "10228168;10441331;10587520;11237011;15944288;16332960;17652751;18579750;19088198;19324876;19324877;20110263;20123908;21741376;22209328;23934149;24278031;25418920;25645385;26360614;26364597;26951377;27062923;27600516;27846572;28459456;28459457;28904123;29393594;29632046;30315122;30385408;30429286;30779550;30833945;31630170;31840817;31844290;32157095;32161166;32183950;32357974;32488085;32860047;32938616;33592498;33912179;34019948;34267371;34932366;35051231;35402882;35513511;35580925;36010968;36074823;36284347;38830870;39129034;39232805;39534244;8702974;8921372;9584153;9651244",
        "class_list": "",
        "function": "KAT6A/YAP/TEAD4 pathway modulates osteoclastogenesis by regulating the RANKL/OPG ratio on the compression side during orthodontic tooth movement. Publication Status: Online-Only, [RefSeq, PubMed]; Novel RTEF-1 transcripts are present within human ocular vascular endothelial cells and mouse neural retina during normal and retinopathy of prematurity development, and alternatively spliced products are produced under hyperoxic and hypoxic conditions, [RefSeq, PubMed]; RBM8A, a new target of TEAD4, promotes breast cancer progression by regulating IGF1R and IRS-2. Publication Status: Online-Only, [RefSeq, PubMed]; The paper described several reasons to designate the putative translation initiation codon as the leucine (TTG) codon, which is 7 codons upstream from the isoleucine (ATT) codon., [RefSeq, PubMed]; The paper described that the ORF of TEF-3 initiates with an ATT codon encoding isoleucine., [RefSeq, PubMed]; This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "H0Y308;Q6MZR9;Q8NEV5;Q92883;Q96BK2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0035329 hippo signaling;GO:0001501 skeletal system development;GO:0007517 muscle organ development",
        "synthesized_glycan_count": 0,
        "hit_score": 7.1,
        "record_id": "Q15561-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z4W1-1",
        "uniprot_id": "DCXR_HUMAN",
        "mass": 25913.0,
        "length": 244,
        "protein_name": "L-xylulose reductase",
        "gene_name": "DCXR",
        "organism": "Human",
        "refseq_name": "L-xylulose reductase isoform 2",
        "refseq_ac": "NP_001182147",
        "gene_names_uniprotkb": "DCXR; SDR20C1",
        "gene_names_refseq": "DCR; DCXR; HCR2; HCRII; KIDCR; P34H; PNTSU; SDR20C1; XR",
        "protein_names_uniprotkb": "L-xylulose reductase; 1.1.1.10; DCXR; Dicarbonyl/L-xylulose reductase; Kidney dicarbonyl reductase; Short chain dehydrogenase/reductase family 20C member 1; Sperm surface protein P34H; XR; kiDCR",
        "protein_names_refseq": "L-xylulose reductase isoform 2; carbonyl reductase 2; carbonyl reductase II; dicarbonyl/L-xylulose reductase; epididymis secretory sperm binding protein; human carbonyl reductase 2; kidney dicarbonyl reductase; short chain dehydrogenase/reductase family 20C member 1; sperm surface protein P34H",
        "tax_id": 9606,
        "disease": "pentosuria (Disease Ontology:DOID:0111258)",
        "pathway": " (hsa:51181);  (R-HSA-5661270);  (R-HSA-5662853)",
        "pathway_count": 3,
        "publication_count": 94,
        "publication_id_list": "10385429;11237011;11882650;12136162;12665801;12680326;12962626;15103634;15809331;15906319;18083107;19337691;22042873;22223895;23179721;23555621;24129315;24275569;24366607;24715725;25418920;25576301;26768311;2691249;26992070;27600516;27920218;28063628;28218747;28228285;28514659;28595002;28832583;28834231;28904123;29242379;29314611;29508533;29557506;29632046;29789417;30315122;30410026;30429286;30484775;30524438;30573663;30779550;31154438;31217245;31530632;31844290;31848261;31998317;32157095;32161166;32350084;32357974;32488085;32897882;32938616;32983136;33298915;33537174;33592498;3365415;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34229054;34357683;34405274;34561969;35051231;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36562355;38665916;40737316;40914422;4392213;7669785;8487505;8722620",
        "class_list": "",
        "function": "Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose (PubMed:11882650, PubMed:19337691, PubMed:40737316). Can use both NAD and NADP as cosubstrate but shows higher activity with NADP (PubMed:11882650). Participates in the uronate cycle of glucose metabolism (PubMed:11882650). May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules (PubMed:11882650)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Crystallization and preliminary crystallographic analysis, [RefSeq, PubMed]; DCXR promotes cell proliferation by promoting the activity of aerobic glycolysis in breast cancer., [RefSeq, PubMed]; Highly expressed in kidney and liver, [RefSeq, PubMed]; Identification of DCXR as an enzyme activity mediating chemical redox cycling suggests that it may be important in generating cytotoxic reactive oxygen species in the lung, [RefSeq, PubMed]; The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BTZ3;Q9UHY9",
        "ec_number_list": "1.1.1.300;1.1.1.-;1.1.1.64;1.1.1.54;1.1.1.216;1.1.1.10",
        "go_molecular_function": "GO:0050038 L-xylulose reductase (NADPH) activity;GO:0042802 identical protein binding;GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0004090 carbonyl reductase (NADPH) activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005903 brush border",
        "go_biological_process": "GO:0005997 xylulose metabolic process;GO:0042732 D-xylose metabolic process;GO:0006006 glucose metabolic process;GO:2000379 positive regulation of reactive oxygen species metabolic process;GO:0019640 D-glucuronate catabolic process to D-xylulose 5-phosphate",
        "synthesized_glycan_count": 0,
        "hit_score": 9.7,
        "record_id": "Q7Z4W1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WV99-1",
        "uniprot_id": "ZFN2B_HUMAN",
        "mass": 28023.0,
        "length": 257,
        "protein_name": "AN1-type zinc finger protein 2B",
        "gene_name": "ZFAND2B",
        "organism": "Human",
        "refseq_name": "AN1-type zinc finger protein 2B isoform 2",
        "refseq_ac": "NP_001257928",
        "gene_names_uniprotkb": "ZFAND2B; AIRAPL",
        "gene_names_refseq": "AIRAPL; ZFAND2B",
        "protein_names_uniprotkb": "AN1-type zinc finger protein 2B; AIRAP-like protein; Arsenite-inducible RNA-associated protein-like protein",
        "protein_names_refseq": "AIRAP-like protein; AN1-type zinc finger protein 2B isoform 2; AN1-type zinc finger protein 2B; arsenite-inducible RNA-associated protein-like protein; zinc finger, AN1-type domain 2B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:130617)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "11237011;19414486;21896481;23301498;24160817;24215362;26337389;26692333;26992070;28657654;28832583;31373491;31492838;32157095;32574038;32938750;32983136;33592498;35132862;35254053;35318648;35705054;40307207",
        "class_list": "",
        "function": "AIRAPL binds to p97 and forms a complex in the endoplasmic reticulum membrane., [RefSeq, PubMed]; An AIP-1 human homologue, ZFAND2B, has a similar protective effect against Abeta toxicity., [RefSeq, PubMed]; Consistent with its proposed role as a tumor suppressor of myeloid transformation, AIRAPL expression is widely abrogated in human myeloproliferative disorders., [RefSeq, PubMed]; Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333)., [UniProtKB, UniProtKB, PubMed]; Results demonstrate that on specific translocation inhibition, a p97-AIRAPL complex directly binds and regulates the efficient processing of polyubiquitinated pQC substrates by the UPS. Results also demonstrate p97's role in pQC processing of preproinsulin in cases of naturally occurring mutations within the signal sequence of insulin., [RefSeq, PubMed]; This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]., [RefSeq]; Zinc finger proteins may be associated with pathophysiology of severe dry eye syndrome., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NB98",
        "ec_number_list": "",
        "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0008270 zinc ion binding;GO:0043130 ubiquitin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0000502 proteasome complex",
        "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045047 protein targeting to ER;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0043567 regulation of insulin-like growth factor receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "Q8WV99-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96K30-1",
        "uniprot_id": "RITA1_HUMAN",
        "mass": 28619.0,
        "length": 269,
        "protein_name": "RBPJ-interacting and tubulin-associated protein 1",
        "gene_name": "RITA1",
        "organism": "Human",
        "refseq_name": "RBPJ-interacting and tubulin-associated protein 1 isoform 2",
        "refseq_ac": "NP_001273144",
        "gene_names_uniprotkb": "RITA1; C12orf52; PSEC0043; RITA",
        "gene_names_refseq": "C12orf52; RITA1; RITA",
        "protein_names_uniprotkb": "RBPJ-interacting and tubulin-associated protein 1; RBPJ-interacting and tubulin-associated protein",
        "protein_names_refseq": "RBPJ-interacting and tubulin-associated protein 1 isoform 2; RBPJ-interacting and tubulin-associated protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84934)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;21102556;24308154;25445601;25588307;31353815;31766533;31844290;31848261;32157095;32161166;32897882;34171305;35701858",
        "class_list": "",
        "function": "Human RITA, binding to Drosophila Su(H) and tubulin, cannot influence the Notch signalling pathway in the fly, [RefSeq, PubMed]; RITA Is Expressed in Trophoblastic Cells and Is Involved in Differentiation Processes of the Placenta. Publication Status: Online-Only, [RefSeq, PubMed]; RITA might suppress tumor growth and induce apoptosis in hepatocellular carcinoma., [RefSeq, PubMed]; RITA overexpression increased expression of p53 and Fbxw7 and downregulated expression of cyclin D1, cyclin E, CDK2, Hes-1 and NF-kappaB p65. These changes led to growth inhibition and induced G0/G1 cell cycle arrest and apoptosis in SMMC7721 and HepG2 cells., [RefSeq, PubMed]; RITA1 drives the growth of bladder cancer cells by recruiting TRIM25 to facilitate the proteasomal degradation of RBPJ., [RefSeq, PubMed]; This study identifies RITA as a novel crucial player in cell migration and invasion by affecting the turnover of focal adhesions through its interference with the dynamics of actin filaments and microtubules. Its deregulation may contribute to malignant progression., [RefSeq, PubMed]; Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis., [UniProtKB, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KVZ4;C9JIN1;F8VRG5;Q53GM3;Q96K25",
        "ec_number_list": "",
        "go_molecular_function": "GO:0015631 tubulin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway;GO:0051168 nuclear export;GO:0022008 neurogenesis;GO:0045746 negative regulation of Notch signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q96K30-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UHC7-1",
        "uniprot_id": "MKRN1_HUMAN",
        "mass": 53349.0,
        "length": 482,
        "protein_name": "E3 ubiquitin-protein ligase makorin-1",
        "gene_name": "MKRN1",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase makorin-1 isoform 2",
        "refseq_ac": "NP_001138597",
        "gene_names_uniprotkb": "MKRN1; RNF61",
        "gene_names_refseq": "MKRN1; RNF61",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase makorin-1; 2.3.2.27; RING finger protein 61; RING-type E3 ubiquitin transferase makorin-1",
        "protein_names_refseq": "E3 ubiquitin-protein ligase makorin-1 isoform 2; E3 ubiquitin-protein ligase makorin-1; RING finger protein 61; RING-type E3 ubiquitin transferase makorin-1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23608);  (R-HSA-198323);  (R-HSA-8948751);  (R-HSA-983168)",
        "pathway_count": 4,
        "publication_count": 110,
        "publication_id_list": "10485710;10843807;10931946;11035045;11062501;11230166;11231573;11237011;11350924;11504915;11715018;12150915;12172553;12244303;12297295;12524439;12646216;14734113;15169778;15183529;15224091;15224092;15527798;15571818;15805468;16595681;16785614;16849449;16954532;17218260;18662542;19028597;19345329;19352404;19452197;19473982;19489725;19536131;19604354;19729658;19851334;19874575;19940261;21532586;22427670;2261476;23419514;24270891;24366607;24367090;24714562;24715725;25547115;25576301;25645385;26154972;26183061;26280536;26375851;26728094;26992070;27600516;27846572;27920218;28218747;28228285;28832583;28834231;29242379;29393594;29493099;29508533;29557506;29632711;29786170;29789417;30429286;31844290;32157095;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33592498;33691108;33717175;33936100;33968037;34087483;34211107;34398495;35051231;35318648;35561310;35580925;36241641;36284347;36938725;37217939;37620897;38480859;39098847;9346240;9380723;9381178;9668046;9812896",
        "class_list": "",
        "function": "CircVPS8 promotes the malignant phenotype and inhibits ferroptosis of glioma stem cells by acting as a scaffold for MKRN1, SOX15 and HNF4A., [RefSeq, PubMed]; Data indicate that MKRN1 is a novel modulator of p53 and p21, preferentially leading cells to p53-dependent apoptosis by suppressing p21., [RefSeq, PubMed]; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription., [UniProtKB, PubMed, PubMed]; Gastrointestinal stromal tumors with BRAF gene fusions. A report of two cases showing low or absent KIT expression resulting in diagnostic pitfalls., [RefSeq, PubMed]; MKRN1 may represent a nuclear protein with multiple nuclear functions, including regulating RNA polymerase II-catalyzed transcription., [RefSeq, PubMed]; MKRN1 promotes colorectal cancer metastasis by activating the TGF-beta signalling pathway through SNIP1 protein degradation. Erratum:[J Exp Clin Cancer Res. 2023 Sep 15;42(1):240. doi: 10.1186/s13046-023-02825-8. PMID: 37710340] Publication Status: Online-Only, [RefSeq, PubMed]; MKRN1 regulates the expression profiles and transcription factor activity in HeLa cells inhibition suppresses cervical cancer cell progression. Publication Status: Online-Only, [RefSeq, PubMed]; MKRN1/2 serve as tumor suppressors in renal clear cell carcinoma by regulating the expression of p53., [RefSeq, PubMed]; This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D1T7;B3KXB4;Q256Y7;Q59G11;Q6GSF1;Q9H0G0;Q9UEZ7;Q9UHW2",
        "ec_number_list": "2.3.2.24;2.3.2.23;2.3.2.26;2.3.2.27;2.3.2.31;2.3.2.-;2.7.11.1;6.2.1.-;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;2.3.2.34;2.3.2.32;3.6.4.-;2.3.2.25;2.3.2.36",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 11.3,
        "record_id": "Q9UHC7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TDR4-1",
        "uniprot_id": "TCP1L_HUMAN",
        "mass": 23863.0,
        "length": 215,
        "protein_name": "T-complex protein 10A homolog 1",
        "gene_name": "TCP10L",
        "organism": "Human",
        "refseq_name": "T-complex protein 10A homolog 1",
        "refseq_ac": "NP_653260",
        "gene_names_uniprotkb": "TCP10L; PRED77",
        "gene_names_refseq": "C21orf77; LINC00846; PRED77; TCP10A-1; TCP10A-2; TCP10L",
        "protein_names_uniprotkb": "T-complex protein 10A homolog 1; T-complex protein 10A-1; TCP10-like; TCP10A-1",
        "protein_names_refseq": "T-complex protein 10A homolog 1; T-complex protein 10A homolog 2; T-complex protein 10A-1; T-complex protein 10A-2; TCP10-like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:140290)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;14586771;15469726;15910542;17377852;24565846;26992070;28834231;32157095;32438969;34171305",
        "class_list": "",
        "function": "Data suggest that the biological function of the interaction between T-complex protein 10-like and MAD4 may be to maintain the differentiation state in liver cells., [RefSeq, PubMed]; May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells., [UniProtKB, PubMed, PubMed]; TCP10L negatively regulates alpha-fetoprotein expression in hepatocellular carcinoma., [RefSeq, PubMed]; The result revealed that TCP10L expressed specifically in the human liver and testis, [RefSeq, PubMed]; The specific expression pattern of TCP10L and interaction with DAPK-3 implies that TCP10L might play crucially important roles in spermatogenesis through its interaction with DAPK-3., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53EW0;Q96LN5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity;GO:0140297 DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q8TDR4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92966-1",
        "uniprot_id": "SNPC3_HUMAN",
        "mass": 46753.0,
        "length": 411,
        "protein_name": "snRNA-activating protein complex subunit 3",
        "gene_name": "SNAPC3",
        "organism": "Human",
        "refseq_name": "snRNA-activating protein complex subunit 3 isoform 1",
        "refseq_ac": "NP_001034786",
        "gene_names_uniprotkb": "SNAPC3; SNAP50",
        "gene_names_refseq": "PTFbeta; SNAP50; SNAPC3",
        "protein_names_uniprotkb": "snRNA-activating protein complex subunit 3; PSE-binding factor subunit beta; PTF subunit beta; Proximal sequence element-binding transcription factor subunit beta; SNAPc 50 kDa subunit; SNAPc subunit 3; Small nuclear RNA-activating complex polypeptide 3; snRNA-activating protein complex 50 kDa subunit",
        "protein_names_refseq": "PSE-binding factor subunit beta; PTF subunit beta; SNAPc 50 kDa subunit; SNAPc subunit 3; proximal sequence element-binding transcription factor subunit beta; small nuclear RNA activating complex, polypeptide 3, 50kDa; small nuclear RNA activating complex, polypeptide 3, 50kD; snRNA-activating protein complex 50 kDa subunit; snRNA-activating protein complex subunit 3 isoform 1; snRNA-activating protein complex subunit 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6619);  (R-HSA-6807505);  (R-HSA-749476);  (R-HSA-76071)",
        "pathway_count": 4,
        "publication_count": 78,
        "publication_id_list": "10022900;10421633;11056176;11237011;11463379;11856838;12414730;12574128;12621023;14701755;1535687;16239144;16308568;16901896;1739980;17525332;18079403;1829677;19667075;20457598;2125285;22137580;22231121;22252320;22441827;23166507;23481700;23932780;24097444;24270878;24715725;24997600;25418920;25576301;25675981;25892735;26154972;26929215;26992070;27846572;27920218;28218747;28228285;28832583;28834231;28904123;29242379;29437277;2944599;30410026;30779550;31844290;31848261;32157095;32357974;33141586;33298915;33717175;33912179;33936100;34932366;35051231;7715707;7891697;8253082;8339931;8628262;8668525;8816454;9003788;9009278;9153304;9188510;9234698;9407024;9418884;9705341;9832505",
        "class_list": "",
        "function": "Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DRI8;Q2VPI6;Q5T285",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003681 bent DNA binding;GO:0003677 DNA binding;GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding;GO:0000995 RNA polymerase III general transcription initiation factor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0019185 snRNA-activating protein complex",
        "go_biological_process": "GO:0009301 snRNA transcription;GO:0006366 transcription by RNA polymerase II;GO:0006383 transcription by RNA polymerase III;GO:0042795 snRNA transcription by RNA polymerase II;GO:0042796 snRNA transcription by RNA polymerase III",
        "synthesized_glycan_count": 0,
        "hit_score": 7.9,
        "record_id": "Q92966-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P84090-1",
        "uniprot_id": "ERH_HUMAN",
        "mass": 12259.0,
        "length": 104,
        "protein_name": "Enhancer of rudimentary homolog",
        "gene_name": "ERH",
        "organism": "Human",
        "refseq_name": "enhancer of rudimentary homolog",
        "refseq_ac": "NP_004441",
        "gene_names_uniprotkb": "ERH",
        "gene_names_refseq": "DROER; ERH",
        "protein_names_uniprotkb": "Enhancer of rudimentary homolog",
        "protein_names_refseq": "enhancer of rudimentary homolog",
        "tax_id": 9606,
        "disease": "disease of metabolism (Disease Ontology:DOID:0014667); juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); hepatocellular adenoma (Disease Ontology:DOID:0050868); idiopathic scoliosis (Disease Ontology:DOID:0060250); Noonan syndrome 1 (Disease Ontology:DOID:0060578); Noonan syndrome with multiple lentigines 1 (Disease Ontology:DOID:0080548); metachondromatosis (Disease Ontology:DOID:0111512); stomach cancer (Disease Ontology:DOID:10534); anogenital venereal wart (Disease Ontology:DOID:11168); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); leukemia (Disease Ontology:DOID:1240); dilated cardiomyopathy (Disease Ontology:DOID:12930); Noonan syndrome with multiple lentigines (Disease Ontology:DOID:14291); glaucoma (Disease Ontology:DOID:1686); chondroma (Disease Ontology:DOID:2602); Noonan syndrome (Disease Ontology:DOID:3490); cervical cancer (Disease Ontology:DOID:4362); tetralogy of Fallot (Disease Ontology:DOID:6419); atrophic gastritis (Disease Ontology:DOID:8929)",
        "pathway": " (hsa:2079)",
        "pathway_count": 1,
        "publication_count": 91,
        "publication_id_list": "11237011;15794639;16984396;19615748;20068231;22121020;22223895;23145069;23186163;23481700;24714562;24715725;25284789;25418920;25469497;25502872;25576301;25755297;25880248;25892735;26154972;26375851;26728094;26758079;26768311;26811146;26992070;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28510447;28649982;28832583;28834231;28860189;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29769354;29786170;30315122;30410026;30429286;30484775;30779550;31154438;31217245;31844290;31848261;31998317;32157095;32161166;32265295;32350084;32387766;32897882;32983136;33214551;33392160;33592498;33691108;33717175;33912179;33968037;34019948;34087483;34433824;34509645;34932366;35051231;35561310;35580925;36047590;36241641;36284347;36334004;36581221;37938771;37997813;38665916;8786099;9029102;9074495",
        "class_list": "",
        "function": "ERH: a plug-and-play protein important for gene silencing and cell cycle progression., [RefSeq, PubMed]; May have a role in the cell cycle., [UniProtKB, UniProtKB, UniProtKB]; Molecular basis for the recognition of CIZ1 by ERH., [RefSeq, PubMed]; Upregulated enhancer of rudimentary homolog promotes epithelial-mesenchymal transition and cancer cell migration in lung adenocarcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 19,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5H2;P70659;Q14259",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0008327 methyl-CpG binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0030496 midbody;GO:0034709 methylosome",
        "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0006213 pyrimidine nucleoside metabolic process;GO:0006139 nucleobase-containing compound metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.4,
        "record_id": "P84090-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q969G2-1",
        "uniprot_id": "LHX4_HUMAN",
        "mass": 43124.0,
        "length": 390,
        "protein_name": "LIM/homeobox protein Lhx4",
        "gene_name": "LHX4",
        "organism": "Human",
        "refseq_name": "LIM/homeobox protein Lhx4",
        "refseq_ac": "NP_203129",
        "gene_names_uniprotkb": "LHX4",
        "gene_names_refseq": "CPHD4; LHX4",
        "protein_names_uniprotkb": "LIM/homeobox protein Lhx4; LIM homeobox protein 4",
        "protein_names_refseq": "LIM homeobox protein 4; LIM/homeobox protein Lhx4",
        "tax_id": 9606,
        "disease": "combined pituitary hormone deficiency 4 (Disease Ontology:DOID:0061017); combined pituitary hormone deficiency (Disease Ontology:DOID:9410)",
        "pathway": " (hsa:89884);  (R-HSA-9010553)",
        "pathway_count": 2,
        "publication_count": 17,
        "publication_id_list": "11237011;11567216;12118377;15567726;17527005;18073311;19706539;22544926;23217742;23481700;23746841;25242263;28473536;33968037;34171305;37948564;7913017",
        "class_list": "",
        "function": "Genetic diagnosis of congenital hypopituitarism in Turkish patients by a target gene panel: novel pathogenic variants in GHRHR, GLI2, LHX4 and POU1F1 genes., [RefSeq, PubMed]; Germline mutations; phenotype characterized by short stature and by pituitary, hindbrain, and skull abnormalities, [RefSeq, PubMed]; In mice, a similar protein plays a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung., [RefSeq, PubMed]; LHX4 expression is transient, and, at 6 weeks of development, is stronger at the caudal than at the cervical level., [RefSeq, PubMed]; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (PubMed:28473536)., [UniProtKB, PubMed]; This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NHE0;Q8NHM1;Q8TCJ1;Q8WWX2;Q969W2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0008327 methyl-CpG binding;GO:0043565 sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030182 neuron differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q969G2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P45974-1",
        "uniprot_id": "UBP5_HUMAN",
        "mass": 95786.0,
        "length": 858,
        "protein_name": "Ubiquitin carboxyl-terminal hydrolase 5",
        "gene_name": "USP5",
        "organism": "Human",
        "refseq_name": "ubiquitin carboxyl-terminal hydrolase 5 isoform 1",
        "refseq_ac": "NP_001092006",
        "gene_names_uniprotkb": "USP5; ISOT",
        "gene_names_refseq": "ISOT; USP5",
        "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 5; 3.4.19.12; Deubiquitinating enzyme 5; Isopeptidase T; Ubiquitin thioesterase 5; Ubiquitin-specific-processing protease 5",
        "protein_names_refseq": "deubiquitinating enzyme 5; testicular tissue protein Li 218; ubiquitin carboxyl-terminal hydrolase 5 isoform 1; ubiquitin carboxyl-terminal hydrolase 5; ubiquitin specific protease 5 (isopeptidase T); ubiquitin thioesterase 5; ubiquitin thiolesterase 5; ubiquitin-specific protease-5 (ubiquitin isopeptidase T); ubiquitin-specific-processing protease 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8078);  (R-HSA-5689880);  (R-HSA-8866652)",
        "pathway_count": 3,
        "publication_count": 160,
        "publication_id_list": "10444327;10982817;11237011;11566882;11923872;12917689;12917691;14661020;15053880;15916963;16142244;16214042;16408927;16564012;16901786;16964243;16964248;17290220;17443180;17580310;17597759;17873522;17924679;17980597;17981138;18172164;18212344;18353650;18467330;18482987;18510355;18632802;18636086;18669648;18767875;19015242;19098288;19135894;19188362;19363159;19398555;19424180;19690332;19838211;19874889;19910467;20058876;20068231;20096447;20166139;20228808;20368735;20501646;21239494;21362556;21571647;21596315;21659512;21849505;21962518;22029577;22085928;22128162;22216260;22223895;22967762;23159851;23186163;23301498;23395819;23486064;23824326;23825189;24056413;24260525;24275569;24493797;24896179;25197364;25305019;25578727;26235645;26853435;26912724;26992070;27133717;28218747;28228285;28467828;28510447;28832583;28834231;28855257;28904123;29242379;29393594;29437277;29557506;29567855;29632046;29769354;30315122;30379171;30429286;30524438;31844290;32119511;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33214551;33298915;33592498;33717175;33912179;33936100;33968037;33981976;34019948;34171305;34185709;34357683;34561969;34725712;35008409;35051231;35154160;35251023;35580925;36010968;36215666;36241641;37208329;37534934;37607937;37938771;38665916;38692507;38772301;39032648;39761299;39900921;40914422;6277905;6305978;7498549;7578059;7851534;8010951;8723724;9074930;9521656",
        "class_list": "",
        "function": "Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The deubiquitinase USP5 promotes cholangiocarcinoma progression by stabilizing YBX1., [RefSeq, PubMed]; USP5 negatively regulates the activation of NLRP3 inflammasomes and participates in the pathological and physiological processes of Sjogren's syndrome., [RefSeq, PubMed]; Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DUS7;D3DUS8;Q96J22",
        "ec_number_list": "3.4.19.12",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043130 ubiquitin binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0101005 deubiquitinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005764 lysosome;GO:0010494 cytoplasmic stress granule",
        "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0016567 protein ubiquitination;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 16.3,
        "record_id": "P45974-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6UXS0-1",
        "uniprot_id": "CL19A_HUMAN",
        "mass": 21431.0,
        "length": 186,
        "protein_name": "C-type lectin domain family 19 member A",
        "gene_name": "CLEC19A",
        "organism": "Human",
        "refseq_name": "C-type lectin domain family 19 member A precursor",
        "refseq_ac": "NP_001243649",
        "gene_names_uniprotkb": "CLEC19A; PRO19627",
        "gene_names_refseq": "CLEC19A",
        "protein_names_uniprotkb": "C-type lectin domain family 19 member A",
        "protein_names_refseq": "C-type lectin domain family 19 member A precursor; C-type lectin domain family 19 member A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:728276)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "11237011;12975309;38167030",
        "class_list": "",
        "function": "CLEC19A overexpression inhibits tumor cell proliferation/migration and promotes apoptosis concomitant suppression of PI3K/AKT/NF-kappaB signaling pathway in glioblastoma multiforme. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A1B0GV53;Q0VF32",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030246 carbohydrate binding",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q6UXS0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IWF6-1",
        "uniprot_id": "DEN6A_HUMAN",
        "mass": 69575.0,
        "length": 608,
        "protein_name": "Protein DENND6A",
        "gene_name": "DENND6A",
        "organism": "Human",
        "refseq_name": "protein DENND6A",
        "refseq_ac": "NP_689891",
        "gene_names_uniprotkb": "DENND6A; FAM116A",
        "gene_names_refseq": "AFI1A; DENND6A; FAM116A",
        "protein_names_uniprotkb": "Protein DENND6A; DENN domain-containing protein 6A",
        "protein_names_refseq": "DENN domain-containing protein 6A; DENN/MADD domain containing 6A; family with sequence similarity 116, member A; protein DENND6A; protein FAM116A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:201627);  (R-HSA-8876198)",
        "pathway_count": 2,
        "publication_count": 213,
        "publication_id_list": "10818110;10990452;11038176;11179213;11237011;11516400;11689439;11703925;11746448;11784320;11917121;12058051;12221131;12244319;12364329;12427552;12475894;12684051;12944476;12972505;15096524;15138286;1516130;15247254;15388334;15528189;15561770;15692570;15878329;15914536;15958533;16207721;16373702;16410077;16525024;16525121;16571673;16641372;16754960;16880209;16950109;17043139;17132146;17189207;17208202;17239822;17287728;17488286;17562788;17574030;17646400;17671165;17678623;18076383;18094055;18354496;18367545;1845915;18477474;18559336;18585354;18664496;18701652;18779367;18804435;1900457;19109890;19345684;19403694;19490898;19620288;19656848;19725050;19729655;19745841;20008558;20068231;20154091;20159109;20159556;20305638;20308558;20404108;20434987;20592283;20797862;20851765;20937701;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21951725;22013193;22065758;22072793;22171327;22365832;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23481700;23645161;23678941;23684622;23713133;23839779;24129315;24296415;24644286;24694596;24715725;24719330;24891604;24917561;24967941;25074980;25341920;25343031;25472813;25576301;25645385;25648148;25713415;25925668;26055712;26154972;26177209;26245486;26434594;26538022;26925400;26936971;27041585;27044746;27103185;27246931;27329675;29557506;31844290;32157095;32357974;32387766;32488085;32897882;32938616;33141586;33298915;33392160;33592498;33691108;33912179;33968037;33981976;34087483;34171305;34405274;34509645;35051231;36010968;36215666;36241641;7688123;7911226;8144603;8408203;8522602;8863739;9020086;9020161;9030515;9136770;9323142;9590177;9733780",
        "class_list": "",
        "function": "FAM116 and Rab14 therefore define an endocytic recycling pathway needed for ADAM protease trafficking and regulation of cell-cell junctions., [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7Z5T4;Q8N235;Q8TEG8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0055037 recycling endosome",
        "go_biological_process": "GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin",
        "synthesized_glycan_count": 0,
        "hit_score": 21.4,
        "record_id": "Q8IWF6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13573-1",
        "uniprot_id": "SNW1_HUMAN",
        "mass": 61494.0,
        "length": 536,
        "protein_name": "SNW domain-containing protein 1",
        "gene_name": "SNW1",
        "organism": "Human",
        "refseq_name": "SNW domain-containing protein 1 isoform 2",
        "refseq_ac": "NP_036377",
        "gene_names_uniprotkb": "SNW1; SKIIP; SKIP",
        "gene_names_refseq": "Bx42; FUN20; NCOA-62; PRPF45; Prp45; SKIIP; SKIP1; SKIP; SNW1",
        "protein_names_uniprotkb": "SNW domain-containing protein 1; Nuclear protein SkiP; Nuclear receptor coactivator NCoA-62; Ski-interacting protein",
        "protein_names_refseq": "SKI interacting protein; SNW domain-containing protein 1 isoform 2; SNW domain-containing protein 1; homolog of Drosophila BX42; nuclear protein SkiP; nuclear receptor coactivator NCoA-62; nuclear receptor coactivator, 62-kD; ski-interacting protein",
        "tax_id": 9606,
        "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); breast carcinoma (Disease Ontology:DOID:3459); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:22938);  (R-HSA-1912408);  (R-HSA-210744);  (R-HSA-2122947);  (R-HSA-2173795);  (R-HSA-2644606);  (R-HSA-2894862);  (R-HSA-350054);  (R-HSA-72163);  (R-HSA-8941856);  (R-HSA-9013508);  (R-HSA-9013695);  (R-HSA-9793380);  (R-HSA-9918481);  (R-HSA-9976102)",
        "pathway_count": 15,
        "publication_count": 332,
        "publication_id_list": "10197981;10199400;10206645;10485843;10531062;10535941;10549282;10587642;10587654;10644367;10713164;10879540;10882063;10882114;10964718;11006133;11014198;11044625;11101529;11112321;11233976;11237011;11278756;11371506;11389444;11427533;11461910;11514567;11585921;11740940;11747608;11753645;11866432;11991638;12050117;12176931;12209127;12354787;12374742;12386158;12391150;12411573;12414731;12466551;12477934;12529369;12530964;12840015;14519844;14625303;14672936;14713954;14762106;14980219;14985122;14991602;15084397;15107403;15194481;15316101;15472075;15531924;15546612;15574878;15684396;15760269;15820681;15824097;15829515;15878163;15905409;16083285;16093323;16102918;16156666;16256737;16314458;16530044;16530045;16595688;16612405;16738328;16751101;16751102;16751179;16809785;17003037;17081983;17095540;17114293;17157496;17287340;17332742;17344417;17401372;17438144;17510063;17540598;17540599;17554337;17591695;17592128;17606899;17646408;17646409;17685488;17823410;18043734;18077452;18094723;18212344;18239137;18296446;1831692;18322460;18374649;18568018;18593880;18669648;18767875;18794151;18824583;18824585;18974129;19103666;19135894;19150886;19151708;19165350;19413330;19415658;19524514;19536130;19651622;19664995;19714243;19723635;19726682;19773441;19800882;19818711;19917253;20007319;20068231;20080834;20090754;20166139;20230923;20351093;20368803;20423332;20442293;20442780;20495621;20801121;20804727;20805998;20972443;20980672;21095583;21245387;21280156;21402699;21406692;21460037;21536652;21551231;21602795;21637926;2176635;21875955;21911577;22045334;22110043;22110129;22223895;22365833;22396495;22959432;22961380;23186163;23222130;23236153;23301498;23345524;24196718;24275569;24304693;24448447;24714562;24737827;24914973;25218447;25417103;25418920;25555158;25576301;2558966;25772364;25810538;26092250;26154972;26385511;26387946;26420826;26801977;26969736;26977885;26992070;27108190;27153775;27377154;27459055;27683217;27749937;27841855;27846572;27862975;28062851;28076346;28178531;28502770;28510447;28781166;28904123;29101237;29146722;29301961;29351928;29360106;29361316;29437277;29493099;29557506;29577978;2963332;29902443;30315277;30379171;30410026;30429286;30599162;30705154;30728453;30765414;30833945;30975767;30995481;31217245;31373491;31409651;31492838;31844290;32157095;32161166;32179686;32265295;32329775;32350084;32387766;32488085;32494006;32502341;32897882;32938616;32983136;33141586;33177556;33214551;33220177;33243851;33392160;33446560;33465208;33509932;33592498;33633747;33691108;33717175;33912179;33968037;33981976;34019948;34087483;34171305;34185709;34229054;34301950;34405274;34822310;34932366;35051231;35215846;35318648;35385551;35561310;35580925;35818332;36010968;36284347;37217939;3757028;37938771;40596516;7566092;7588063;8001118;8566756;8608946;8649374;8687460;8878478;8973337;9016565;9242493;9244301;9315665;9462510;9512519;9524131;9539711;9569025;9604939;9620803;9632709;9651681;9671485;9693032;9694793;9701291;9731529;9819428",
        "class_list": "",
        "function": "(Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter., [UniProtKB, PubMed, PubMed]; (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters., [UniProtKB, PubMed]; Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Involved in pre-mRNA splicing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K8A9;Q13483;Q32N03;Q5D0D6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0019899 enzyme binding;GO:0003714 transcription corepressor activity;GO:0005112 Notch binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0016363 nuclear matrix",
        "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 33.8,
        "record_id": "Q13573-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H7T3-1",
        "uniprot_id": "CJ095_HUMAN",
        "mass": 26270.0,
        "length": 257,
        "protein_name": "Uncharacterized protein C10orf95",
        "gene_name": "C10orf95",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "C10orf95",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Uncharacterized protein C10orf95",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79946)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "11237011;24715725;39894887",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AVQ7",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q9H7T3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q69YU5-1",
        "uniprot_id": "UQCC6_HUMAN",
        "mass": 8023.0,
        "length": 71,
        "protein_name": "Ubiquinol-cytochrome c reductase complex assembly factor 6",
        "gene_name": "UQCC6",
        "organism": "Human",
        "refseq_name": "ubiquinol-cytochrome c reductase complex assembly factor 6",
        "refseq_ac": "NP_001129042",
        "gene_names_uniprotkb": "UQCC6; BRAWNIN; BR; C12orf73",
        "gene_names_refseq": "BRAWNIN; BR; C12orf73; UQCC6",
        "protein_names_uniprotkb": "Ubiquinol-cytochrome c reductase complex assembly factor 6; Protein BRAWNIN",
        "protein_names_refseq": "protein BRAWNIN; ubiquinol-cytochrome c reductase complex assembly factor 6; uncharacterized protein C12orf73",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:728568);  (R-HSA-9865881)",
        "pathway_count": 2,
        "publication_count": 27,
        "publication_id_list": "11237011;21278747;23168492;24385928;25008109;25605331;28380382;28467828;28673544;28844695;28904123;29242379;29243944;31092671;31844290;32157095;32161166;32161263;32929120;33392160;33691108;34357683;34969438;35251023;36241641;36581221;37769950",
        "class_list": "",
        "function": "Knockdown of BRAWNIN minimally affect mitochondrial complex III assembly in human cells., [RefSeq, PubMed]; Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (PubMed:32161263). Mediates early complex III biogenesis (By similarity). Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (By similarity). Also required for cytochrome c oxidase complex (complex IV) assembly (PubMed:34969438)., [UniProtKB, PubMed, PubMed, UniProtKB]; Study demonstrate that BRAWNIN, a 71 a.a. peptide encoded by C12orf73, is essential for respiratory chain complex III (CIII) assembly. In human cells, BRAWNIN is induced by the energy-sensing AMPK pathway, and its depletion impairs mitochondrial ATP production. Findings demonstrate that BRAWNIN is essential for vertebrate oxidative phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane",
        "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0034551 mitochondrial respiratory chain complex III assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q69YU5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NZD2-1",
        "uniprot_id": "GLTP_HUMAN",
        "mass": 23850.0,
        "length": 209,
        "protein_name": "Glycolipid transfer protein",
        "gene_name": "GLTP",
        "organism": "Human",
        "refseq_name": "glycolipid transfer protein",
        "refseq_ac": "NP_057517",
        "gene_names_uniprotkb": "GLTP",
        "gene_names_refseq": "GLTP",
        "protein_names_uniprotkb": "Glycolipid transfer protein; GLTP",
        "protein_names_refseq": "glycolipid transfer protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51228);  (R-HSA-9845576)",
        "pathway_count": 2,
        "publication_count": 71,
        "publication_id_list": "10671554;11237011;15107860;15287756;15329726;15504043;16103222;17105344;17687330;17980653;18261224;18317235;19940249;20068231;2190982;23290777;23481700;23791178;23863933;24397554;24715725;25576301;26202220;26375851;26811146;27397612;27862975;27920218;28218747;28228285;28832583;28904123;29164996;29242379;29331515;29393594;29437277;29493099;29557506;30206120;30315122;30429286;30779550;31568712;31844290;31848261;32157095;32161166;32339554;32350084;32357974;32488085;32983136;33141586;33298915;33537174;33592498;33717175;33912179;33936100;33968037;34185709;34357683;34499882;35051231;35580925;36010968;36284347;36924944;37191854;37938771",
        "class_list": "glycogene",
        "function": "Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Crystal structures of apo-GLTP (1.65 A resolution) and lactosylceramide-bound (1.95 A) GLTP, in which the bound glycosphingolipid is sandwiched, after adaptive recognition, within a previously unknown two-layer all-alpha-helical topology, [RefSeq, PubMed]; Emerging roles for human glycolipid transfer protein superfamily members in the regulation of autophagy, inflammation, and cell death. Review article, [RefSeq, PubMed]; First insights into human GLTP structural dynamics by fluorescence spectroscopy, including global conformational changes that accompany GLTP folding into an active conformational state., [RefSeq, PubMed]; Four bulky, conserved hydrophobic residues involved in 'sensor-like' interactions with lipid chains in protein hydrophobic pockets and FF motifs in GLTP and FAPP2., [RefSeq, PubMed]; Glycolipid transfer protein knockout disrupts vesicle trafficking to the plasma membrane., [RefSeq, PubMed]; Role of Gltp in Maturation of Oligodendrocytes Under the Regulation of Nkx2.2., [RefSeq, PubMed]; The paper describes the complete primary amino acid sequence of glycolipid transfer protein (GLTP) from porcine brain. The sequence was determined by Edman degradation., [RefSeq, PubMed]; The protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids and glyceroglycolipids between membranes. It is thought to be a cytoplasmic protein. [provided by RefSeq, Jul 2008]., [RefSeq]; The rate-limiting step for glycolipid transfer protein (GLTP) action appears to be the surface processes leading to the GLTP-glycosphingolipid complex formation and release associated with a shuttle/carrier mode of action., [RefSeq, PubMed]; This paper describes the first cloning of the cDNAs encoding the glycolipid transfer proteins of bovine and porcine brain.  The cDNAs are highly homologous to the human cDNA (AF209704)., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 247,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53Z13;Q96J68",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0008289 lipid binding;GO:1902387 ceramide 1-phosphate binding;GO:1902388 ceramide 1-phosphate transfer activity;GO:0017089 glycolipid transfer activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0035627 ceramide transport;GO:0035902 response to immobilization stress;GO:0120009 intermembrane lipid transfer;GO:0046317 regulation of glucosylceramide biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q9NZD2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q3KR16-1",
        "uniprot_id": "PKHG6_HUMAN",
        "mass": 88960.0,
        "length": 790,
        "protein_name": "Pleckstrin homology domain-containing family G member 6",
        "gene_name": "PLEKHG6",
        "organism": "Human",
        "refseq_name": "pleckstrin homology domain-containing family G member 6 isoform a",
        "refseq_ac": "NP_001138328",
        "gene_names_uniprotkb": "PLEKHG6",
        "gene_names_refseq": "ARHGEF46; MyoGEF; PLEKHG6",
        "protein_names_uniprotkb": "Pleckstrin homology domain-containing family G member 6; MyoGEF; Myosin-interacting guanine nucleotide exchange factor; PH domain-containing family G member 6",
        "protein_names_refseq": "PH domain-containing family G member 6; myosin II interacting GEF; myosin interacting guanine nucleotide exchange factor; pleckstrin homology domain containing, family G (with RhoGef domain) member 6; pleckstrin homology domain-containing family G member 6 isoform a; pleckstrin homology domain-containing family G member 6",
        "tax_id": 9606,
        "disease": "cystic fibrosis (Disease Ontology:DOID:1485)",
        "pathway": " (hsa:55200);  (R-HSA-8980692);  (R-HSA-9013149)",
        "pathway_count": 3,
        "publication_count": 286,
        "publication_id_list": "10037681;10232922;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10619026;10699171;10699464;10873388;10873802;10958683;11007481;11058585;11085924;11149925;11207612;11237011;11373293;11396949;11431473;11432776;11584276;11606631;11672528;11680691;11689693;11704860;11707441;11756552;11773441;11803464;11804587;11804589;11804590;11884391;11912491;11961559;12071859;12093360;12096337;12195014;12221077;12221096;12351724;12432077;12531887;12546821;12547822;12650940;12665586;12857875;12877655;12923183;14512443;14514689;1464587;14675773;14718541;15023524;15033976;15064355;15107133;15133129;15147912;15302923;15339924;15342493;15485661;15498874;15507211;15579468;15601624;15611138;15728722;15850391;15858067;15866170;15897194;16002401;16112081;16116428;16184169;16217026;16243036;16467373;16473593;16492808;16507994;16519628;16630611;16636067;16702231;16721066;16762923;16776779;16777452;16777849;16862148;16896804;16914516;16968698;17077126;17145773;17196961;17214551;17244649;17562871;17583407;17599059;17702745;17765681;17804252;17881735;17932950;17942708;17976533;18006505;18045877;18158243;18218625;18249095;18347018;18396277;18426980;18653540;18694934;18829452;18838382;19129481;19269969;19421144;19494238;19605563;19635168;19673492;19713215;19934221;20030946;20101212;20400958;20460433;20591975;20628200;20660154;20679435;20810653;21148482;21351730;21454492;21542010;21565175;21613211;21699497;21730051;21865595;21936715;21989057;22004470;22096251;22298643;22305756;22407364;22475431;22608513;22673745;22734669;22911862;22970203;22992742;23200924;23209303;23255595;23288169;23434736;23572525;23707487;23718289;23870313;23940355;24086303;24128008;24259668;24335996;24352656;24482237;24715725;24859002;24933155;24960694;25024229;25211221;25428919;25704760;25721503;25795300;25862245;26129894;26371245;26529257;26887924;27117132;27145964;27216196;27481945;27555588;27566826;27713499;27806292;27862975;27986909;28112683;28114311;28196833;28584191;28904123;29089502;29146911;29242379;29321250;29358323;29382922;29508533;30379171;30517861;30853411;31105010;31844290;31871319;31988071;32203420;32488085;33592498;34932366;35051231;7479768;7512369;7559638;7673236;7721814;7753201;7835339;8021274;8107774;8537347;8543060;8571126;8617235;8643598;8645157;8649427;8662891;8756646;8769096;8798539;8805223;8807639;8810315;8816443;8939998;8990121;8994827;9013646;9099726;9111050;9113980;9305890;9418861;9438849;9490638;9497316;9535835;9548756;9582072;9659915;9670022;9792683;9822598;9822605;9829970;9843499;9988689",
        "class_list": "",
        "function": "Ezrin allows the local activation of RhoG at the apical pole of epithelial cells by recruiting upstream and downstream regulators of RhoG and that both PLEKHG6 and ezrin are required for efficient macropinocytosis, [RefSeq, PubMed]; Ezrin interacts with MYOGEF and recruits it to retracting blebs, where MYOGEF activates RhoA and promotes the reassembly of the cortical actomyosin network at the bleb membrane, thus contributing to the regulation of bleb retraction., [RefSeq, PubMed]; Genetic Predisposition to Colon and Rectal Adenocarcinoma Is Mediated by a Super-enhancer Polymorphism Coactivating CD9 and PLEKHG6., [RefSeq, PubMed]; Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis., [UniProtKB, PubMed, PubMed]; MyoGEF cooperates with nonmuscle myosin IIA to regulate the polarity and invasion activity of breast cancer cells through activation of RhoA and RhoC., [RefSeq, PubMed]; PLEKHG6 isoform is an example of a primate-specific genomic element supporting brain development., [RefSeq, PubMed]; Plk1 can regulate MyoGEF activity and localization, contributing to the regulation of cytokinesis, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3SWR1;Q8N1P1;Q8WYY1;Q9H8F4;Q9NVK9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005829 cytosol;GO:0030054 cell junction;GO:0032154 cleavage furrow;GO:0005902 microvillus",
        "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 28.9,
        "record_id": "Q3KR16-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96GF1-1",
        "uniprot_id": "RN185_HUMAN",
        "mass": 20459.0,
        "length": 192,
        "protein_name": "E3 ubiquitin-protein ligase RNF185",
        "gene_name": "RNF185",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase RNF185 isoform 2",
        "refseq_ac": "NP_001129297",
        "gene_names_uniprotkb": "RNF185",
        "gene_names_refseq": "RNF185",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF185; 2.3.2.27; RING finger protein 185",
        "protein_names_refseq": "BSK65-MONO1; BSK65-MONO2; BSK65-PANC1; BSK65-PANC2; BSK65-TEST1; BSK65-TEST2; BSK65-TEST3; E3 ubiquitin-protein ligase RNF185 isoform 2; E3 ubiquitin-protein ligase RNF185; RING-type E3 ubiquitin transferase RNF185",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91445);  (R-HSA-382556);  (R-HSA-5678895);  (R-HSA-901032);  (R-HSA-9931269)",
        "pathway_count": 5,
        "publication_count": 97,
        "publication_id_list": "10409699;10484077;10665657;10694380;10748049;11146634;11504826;11562789;11812794;12379217;12379510;12403779;12604685;12913004;1352877;1356264;1359686;1377674;14661924;15175422;15472518;15611333;15713668;15863492;15899824;16431915;16816140;16901789;1695717;17523162;17855752;17894550;17977821;18003979;18264092;18282684;18417469;18426978;18434309;18716059;19002207;19084021;19447222;19570978;1968359;19862647;1998343;20583968;20621639;21083385;2135388;21652558;21931693;22047557;2210768;22178883;22318583;2236053;23063411;23232094;24019521;24685677;24727453;2475911;25092655;25133187;25584290;2570070;2570460;26208431;27485036;28132103;28273161;2898143;29055231;30118680;30334692;30334693;31217245;31679946;31844290;32350084;32357974;32981041;34357683;3457471;3472246;35183197;37831068;7523390;7529176;7553863;7553864;7865904;9652413;9816258;9831708",
        "class_list": "",
        "function": "CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587. Publication Status: Online-Only, [RefSeq, PubMed]; Data thus identify RNF185 and RNF5 as a novel E3 ligase module that is central to the control of CFTR degradation., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (PubMed:21931693). Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (PubMed:27485036). Protects cells from ER stress-induced apoptosis (PubMed:27485036). Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (PubMed:24019521). Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS at 'Lys-173' and 'Lys-384', thereby promoting CGAS cyclic GMP-AMP synthase activity (PubMed:28273161). Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Human BNIP1 colocalizes with RNF185 at mitochondria and is polyubiquitinated by RNF185 through K63-based ubiquitin linkage in vivo., [RefSeq, PubMed]; RNF185 Control of COL3A1 Expression Limits Prostate Cancer Migration and Metastatic Potential., [RefSeq, PubMed]; These results indicate that RNF185 negatively regulates osteogenesis through the degradation of Dvl2 and down-regulation of canonical Wnt signaling pathway and suggest a possible therapeutic target in osteoporosis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5C1;A9X3T8;Q8N900",
        "ec_number_list": "2.3.2.27;5.6.1.6;3.6.4.6;2.3.2.36",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding;GO:0061630 ubiquitin protein ligase activity;GO:0043130 ubiquitin binding;GO:0044390 ubiquitin-like protein conjugating enzyme binding",
        "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0044322 endoplasmic reticulum quality control compartment",
        "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0055085 transmembrane transport;GO:0006914 autophagy;GO:0006511 ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.8,
        "record_id": "Q96GF1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H0X6-1",
        "uniprot_id": "RN208_HUMAN",
        "mass": 27964.0,
        "length": 261,
        "protein_name": "RING finger protein 208",
        "gene_name": "RNF208",
        "organism": "Human",
        "refseq_name": "RING finger protein 208 isoform 1",
        "refseq_ac": "NP_112587",
        "gene_names_uniprotkb": "RNF208",
        "gene_names_refseq": "RNF208",
        "protein_names_uniprotkb": "RING finger protein 208",
        "protein_names_refseq": "RING finger protein 208 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:727800)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "11230166;19690332;31154438;31862882;35580925",
        "class_list": "",
        "function": "RING finger protein 208 (RNF208) decreases the stability of soluble Vimentin protein through a polyubiquitin-mediated proteasomal degradation pathway, thereby suppressing metastasis of triple-negative breast cancer (TNBC) cells. RNF208 was significantly lower in TNBC than the luminal type, and low expression of RNF208 was strongly associated with poor clinical outcomes. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2BFA0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0016567 protein ubiquitination;GO:0051865 protein autoubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q9H0X6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NW64-1",
        "uniprot_id": "RBM22_HUMAN",
        "mass": 46896.0,
        "length": 420,
        "protein_name": "Pre-mRNA-splicing factor RBM22",
        "gene_name": "RBM22",
        "organism": "Human",
        "refseq_name": "pre-mRNA-splicing factor RBM22",
        "refseq_ac": "NP_060517",
        "gene_names_uniprotkb": "RBM22; 199G4; ZC3H16",
        "gene_names_refseq": "Cwc2; RBM22; ZC3H16; fSAP47",
        "protein_names_uniprotkb": "Pre-mRNA-splicing factor RBM22; RNA-binding motif protein 22; Zinc finger CCCH domain-containing protein 16",
        "protein_names_refseq": "functional spliceosome-associated protein 47; pre-mRNA-splicing factor RBM22; zinc finger CCCH domain-containing protein 16",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55696);  (R-HSA-72163);  (R-HSA-9918481)",
        "pathway_count": 3,
        "publication_count": 192,
        "publication_id_list": "10882114;11014198;11101529;11230166;11233976;11237011;11747608;11991638;12176931;12411573;12414731;12477934;14519844;14625303;14713954;14762106;15084397;16314458;16809785;17045351;17095540;17332742;17606899;18322460;18593880;18991276;19103666;19133299;19165350;19536130;19608861;20068231;20423332;20980672;21122810;21536652;2176635;21872626;21911577;22110043;22223895;22246180;22365833;22959432;22961380;23186163;23222130;23236153;23345524;23481700;23783831;24196718;24304693;24366607;24448447;24714562;24737827;24914973;25218447;25418920;25555158;25576301;2558966;25645385;25880248;25892735;26092250;26154972;26375851;26385511;26420826;26728094;26811146;26969736;26992070;27108190;27377154;27459055;27543614;27600516;27683217;27846572;27862975;27920218;28062851;28063628;28076346;28228285;28502770;28510447;28781166;28832583;28834231;28855257;29242379;29301961;29360106;29361316;29393594;29493099;29508533;29557506;29632046;29632711;2963332;29769354;29786170;29902443;30315122;30315277;30379171;30410026;30429286;30524438;30599162;30705154;30728453;30765414;30779550;30833945;30975767;31154438;31217245;31222486;31373491;31409651;31530632;31844290;31848261;32157095;32161166;32179686;32265295;32329775;32357974;32387766;32494006;32502341;32897882;32938616;32983136;33123756;33177556;33220177;33243851;33298915;33392160;33446560;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34087483;34171305;34301950;34509645;34561969;34822310;34932366;35051231;35215846;35318648;35385551;35580925;36010968;36089245;36215666;36241641;36284347;3757028;37938771;38641822;38665916;40268057;40596516;40914422;8566756;8608946;8681136;9016565;9242493;9512519;9524131;9539711;9671485;9701291;9731529",
        "class_list": "",
        "function": "ALG-2 alone evenly distributed within the cell, whereas in the presence of RBM22 the two proteins co-localized within the nucleus., [RefSeq, PubMed]; RBM22 is implicated in cell cycle progression, [RefSeq, PubMed]; RBM22 regulates RNA polymerase II 5' pausing, elongation rate, and termination by coordinating 7SK-P-TEFb complex and SPT5. Publication Status: Online-Only, [RefSeq, PubMed]; Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154). Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X. [provided by RefSeq, Mar 2009]., [RefSeq]; Tumor suppressor role of RBM22 in prostate cancer acting as a dual-factor regulating alternative splicing and transcription of key oncogenic genes., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NDM5;B4DLI9;O95607",
        "ec_number_list": "",
        "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0048306 calcium-dependent protein binding;GO:0017070 U6 snRNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0071013 catalytic step 2 spliceosome;GO:0071006 U2-type catalytic step 1 spliceosome",
        "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0033120 positive regulation of RNA splicing;GO:0046827 positive regulation of protein export from nucleus;GO:0071466 cellular response to xenobiotic stimulus;GO:0000398 mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 19.6,
        "record_id": "Q9NW64-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UNS1-1",
        "uniprot_id": "TIM_HUMAN",
        "mass": 138658.0,
        "length": 1208,
        "protein_name": "Protein timeless homolog",
        "gene_name": "TIMELESS",
        "organism": "Human",
        "refseq_name": "protein timeless homolog isoform 2",
        "refseq_ac": "NP_001317224",
        "gene_names_uniprotkb": "TIMELESS; TIM1; TIMELESS1; TIM",
        "gene_names_refseq": "FASPS4; TIM1; TIMELESS; TIM; hTIM",
        "protein_names_uniprotkb": "Protein timeless homolog; hTIM",
        "protein_names_refseq": "Tof1 homolog; protein timeless homolog isoform 2; protein timeless homolog; timeless circadian clock 1",
        "tax_id": 9606,
        "disease": "advanced sleep phase syndrome 4 (Disease Ontology:DOID:0061006); alcohol use disorder (Disease Ontology:DOID:1574)",
        "pathway": " (hsa:8914);  (R-HSA-5693607)",
        "pathway_count": 2,
        "publication_count": 165,
        "publication_id_list": "10859164;11080452;11139606;11301010;11376695;11382904;11390642;12152085;12545175;12578958;12791985;14576433;15189136;15190204;15302935;15707391;15798197;16148040;16153896;16327781;16360315;16530042;16885023;16959974;16964243;17081983;17102137;17116885;17141802;17296725;17547437;17575048;17924679;17928296;17965729;18171670;18452278;18669648;18691976;18767875;18805091;18923075;18971343;19357644;19413330;19419957;19651622;19664994;19690332;19691289;20068231;20124417;20139726;20154705;20233725;21052091;21240188;21263215;21325134;21335604;21406692;21659603;21670590;21680713;21777809;22021381;22024395;22231403;22424782;22635276;22661229;22661230;22792074;22977173;23186163;23345434;23359676;23418588;23468639;23481700;24366607;24397554;25113031;25122754;25418920;25558984;25576301;25645385;25659039;25880248;25892735;26154972;26344098;26503245;26992070;27600516;27846572;27862975;27920218;28228285;28334766;28514659;28832583;28834231;28904123;29242379;29393594;29557506;29632046;29769354;29786170;30315122;30356214;30429286;30524438;30833945;31138685;31154438;31217245;31222486;31530632;31844290;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32705708;32938616;33141586;33298915;33392160;33592498;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34405274;34509645;34694004;34700328;34932366;35051231;35251023;35561310;35585232;36010968;36172813;36241641;36581221;37074911;38178094;38261568;38354174;38751015;38801073;9705271;9856465;9891984",
        "class_list": "",
        "function": "M6A-mediated hsa_circ_0061179 inhibits DNA damage in ovarian cancer cells via miR-143-3p/TIMELESS., [RefSeq, PubMed]; NcRNAs-mediated TIMELESS overexpression in lung adenocarcinoma correlates with reduced tumor immune cell infiltration and poor prognosis. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:23418588, PubMed:26344098, PubMed:31138685, PubMed:32705708, PubMed:35585232, PubMed:9856465). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:35585232). During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (PubMed:23359676). TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX11 (PubMed:32705708). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214, PubMed:31138685). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588, PubMed:31138685). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:31138685, PubMed:9856465). May play a role as destabilizer of the PER2-CRY2 complex (PubMed:31138685). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; SP3-induced Timeless transcription contributes to cell growth of lung adenocarcinoma cells. Publication Status: Online-Only, [RefSeq, PubMed]; TIMELESS promotes reprogramming of glucose metabolism in oral squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; The TIMELESS and PARP1 interaction suppresses replication-associated DNA gap accumulation., [RefSeq, PubMed]; The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 9641,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2ZAV0;O94802;Q86VM1;Q8IWH3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008047 enzyme activator activity;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0031298 replication fork protection complex;GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0051301 cell division;GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 16.8,
        "record_id": "Q9UNS1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UL33-1",
        "uniprot_id": "TPC2L_HUMAN",
        "mass": 16146.0,
        "length": 140,
        "protein_name": "Trafficking protein particle complex subunit 2-like protein",
        "gene_name": "TRAPPC2L",
        "organism": "Human",
        "refseq_name": "trafficking protein particle complex subunit 2-like protein isoform 1",
        "refseq_ac": "NP_001305453",
        "gene_names_uniprotkb": "TRAPPC2L; HSPC126",
        "gene_names_refseq": "HSPC176; PERRB; TRAPPC2L",
        "protein_names_uniprotkb": "Trafficking protein particle complex subunit 2-like protein",
        "protein_names_refseq": "hematopoietic stem/progenitor cells 176; trafficking protein particle complex 2 like; trafficking protein particle complex subunit 2-like protein isoform 1; trafficking protein particle complex subunit 2-like protein",
        "tax_id": 9606,
        "disease": "encephalopathy, progressive, early-onset, with episodic rhabdomyolysis (MONDO:MONDO:0032681)",
        "pathway": " (hsa:51693);  (R-HSA-204005);  (R-HSA-8876198)",
        "pathway_count": 3,
        "publication_count": 308,
        "publication_id_list": "10445031;10559959;10679020;10747087;10788476;10818110;10825291;10903204;10982397;10990452;11035026;11038176;11179213;11237011;11285137;11306556;11516400;11689439;11703925;11746448;11784320;11917121;11927603;12058051;12070132;12221131;12235121;12244319;12364329;12427552;12475894;12684051;12944476;12972505;15037235;15096524;15138286;1516130;15247254;15388334;15528189;15561770;15692570;15878329;15914536;15958533;16207721;16303754;16373702;16410077;16495487;16525024;16525121;16571673;16624868;16641372;16754960;16880209;16912714;16950109;17005010;17038314;17043139;17132146;17189207;17192411;17208202;17239822;17287728;17316621;17488286;17562788;17574030;17646400;17671165;17678623;17684057;18076383;18094055;18354496;18367545;1845915;18477474;18559336;18585354;18664496;18701652;18779367;18804435;18843296;1900457;19109890;19164740;19345684;19403694;19416478;19490898;19620288;19638414;19656848;19725050;19729655;19745841;20008558;20154091;20159109;20159556;20305638;20308558;20404108;20434987;20545907;20592283;20679433;20797862;20851765;20937701;20966969;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21478858;21525244;21532587;21554507;21586568;21683469;21689688;21706022;21718402;21776405;21951725;22013193;22065758;22072793;22157747;22171327;22365832;22424782;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22675024;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23479643;23481700;23645161;23678941;23684622;23698585;23713133;23839779;23864707;24119662;24296415;24397554;24644286;24694596;24714562;24715725;24719330;24891604;24917561;24967941;25074980;25202031;25341920;25343031;25406594;25472813;25492864;25576301;25586378;25619252;25645385;25648148;25713415;25925668;26055712;26154972;26177209;26245486;26375851;26434594;26538022;26728094;26758079;26811146;26925400;26936971;26992070;27041585;27044746;27103185;27246931;27329675;27600516;27862975;27920218;28228285;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29786170;29789417;30120216;30315122;30429286;30524438;30779550;31217245;31844290;31848261;31937595;31998317;32157095;32350084;32357974;32387766;32488085;32502341;32843486;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34405274;34509645;34932366;35051231;35318648;35561310;35580925;36010968;36241641;36284347;36849228;37938771;7688123;7911226;8144603;8221884;8408203;8522602;8620540;8663406;8863739;9020086;9020161;9030515;9094723;9136770;9150144;9177194;9307973;9323142;9590177;9647643;9733780",
        "class_list": "",
        "function": "A novel homozygous variant in TRAPPC2L results in a neurodevelopmental disorder and disrupts TRAPP complex function., [RefSeq, PubMed]; Plays a role in vesicular transport from endoplasmic reticulum to Golgi., [UniProtKB, PubMed, PubMed]; TRAPPC2L-related disorder: first homozygous protein-truncating variant and further delineation of the phenotype., [RefSeq, PubMed]; This gene encodes a protein that interacts with the tethering factor trafficking protein particle (TRAPP complex). TRAPP complexes mediate the contact between vescicles and target membranes, and thus, are involved in vescicle-mediated transport of proteins and lipids. The encoded protein is related to the X-linked trafficking protein particle complex 2. A related pseudogene is located on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R4M9;Q6ZTA7;Q9NZZ4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol",
        "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048208 COPII vesicle coating;GO:0006901 vesicle coating;GO:0099022 vesicle tethering",
        "synthesized_glycan_count": 0,
        "hit_score": 30.9,
        "record_id": "Q9UL33-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P59665-1",
        "uniprot_id": "DEF1_HUMAN",
        "mass": 10201.0,
        "length": 94,
        "protein_name": "Neutrophil defensin 1",
        "gene_name": "DEFA1B; DEFA1",
        "organism": "Human",
        "refseq_name": "neutrophil defensin 1 isoform 2 preproprotein",
        "refseq_ac": "NP_001035965",
        "gene_names_uniprotkb": "DEFA1B; DEFA1; DEF1; DEFA2; MRS",
        "gene_names_refseq": "DEFA1B; HNP-1; HP-1; HP1",
        "protein_names_uniprotkb": "Neutrophil defensin 1; Defensin, alpha 1; HNP-1; HNP-2; HP-1; HP-2; HP1; HP2",
        "protein_names_refseq": "neutrophil defensin 1 isoform 2 preproprotein; neutrophil defensin 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:1667);  (hsa:728358);  (R-HSA-1461973);  (R-HSA-1462054);  (R-HSA-6798695)",
        "pathway_count": 5,
        "publication_count": 51,
        "publication_id_list": "10618521;12021776;12060767;12949495;1302183;1339298;1445872;1445873;15064728;15210812;15246937;15340161;1547345;15616305;17088326;17142766;17452329;18191790;18973303;2006422;2019582;20214904;20220136;20385753;21904558;23650620;24236072;2500436;26154972;2668334;27031443;2917986;2918759;29557506;29683978;29738776;2997278;31471397;3174637;31844290;3370315;34171305;34185709;35080426;4056036;7833799;8329717;8477861;8530462;8692836;9169779",
        "class_list": "",
        "function": "DEFA1B encodes an antibacterial peptide that is bacteriocidal against S. aureus, E. coli, and P. aeruginosa., [RefSeq, PubMed]; Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]., [RefSeq]; Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses or by promoting the activation and maturation of some APCs (PubMed:15616305, PubMed:17142766, PubMed:20220136, PubMed:24236072). Interacts with the essential precursor of cell wall synthesis lipid II to inhibit bacterial cell wall synthesis (PubMed:20214904). Inhibits adenovirus infection via inhibition of viral disassembly at the vertex region, thereby restricting the release of internal capsid protein pVI, which is required for endosomal membrane penetration during cell entry (PubMed:18191790). In addition, interaction with adenovirus capsid leads to the redirection of viral particles to TLR4 thereby promoting a NLRP3-mediated inflammasome response and interleukin 1-beta (IL-1beta) release (PubMed:35080426). Induces the production of proinflammatory cytokines including type I interferon (IFN) in plasmacytoid dendritic cells (pDCs) by triggering the degradation of NFKBIA and nuclear translocation of IRF1, both of which are required for activation of pDCs (PubMed:27031443)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Human Neutrophil Peptide 1 directly binds and neutralizes Exotoxin A of Pseudomonas aeruginosa., [RefSeq, PubMed]; Inflammatory regulation of defensin alpha 1 (human neutrophil peptide 1; HNP-1) in pancreatic ductal adenocarcinoma (PDAC) tissue and cells indicates that HNP-1 may be a link between chronic inflammation and malignant transformation in the pancreas., [RefSeq, PubMed]; Our findings suggest that DEFA1B and NLRP3 gene expression levels can be used as valuable biologic markers for estimation of disease activity in NBD and as potential targets for future therapeutic trials for inflammatory disorders., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P11479;Q14125;Q6EZF6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0140911 pore-forming activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005796 Golgi lumen;GO:0070062 extracellular exosome;GO:0035578 azurophil granule lumen",
        "go_biological_process": "GO:0006935 chemotaxis;GO:0006955 immune response;GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium",
        "synthesized_glycan_count": 0,
        "hit_score": 5.2,
        "record_id": "P59665-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BSL1-1",
        "uniprot_id": "UBAC1_HUMAN",
        "mass": 45338.0,
        "length": 405,
        "protein_name": "Ubiquitin-associated domain-containing protein 1",
        "gene_name": "UBAC1",
        "organism": "Human",
        "refseq_name": "ubiquitin-associated domain-containing protein 1",
        "refseq_ac": "NP_057256",
        "gene_names_uniprotkb": "UBAC1; GBDR1; KPC2; UBADC1",
        "gene_names_refseq": "GBDR1; KPC2; UBAC1; UBADC1",
        "protein_names_uniprotkb": "Ubiquitin-associated domain-containing protein 1; Glialblastoma cell differentiation-related protein 1; Kip1 ubiquitination-promoting complex protein 2; UBA domain-containing protein 1",
        "protein_names_refseq": "E3 ubiquitin-protein ligase subunit KPC2; Kip1 ubiquitination-promoting complex subunit 2; UBA domain-containing protein 1; glialblastoma cell differentiation-related protein 1; kip1 ubiquitination-promoting complex protein 2; putative glialblastoma cell differentiation-related protein; testicular secretory protein Li 64; ubiquitin associated domain containing 1; ubiquitin-associated domain-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10422);  (R-HSA-983168)",
        "pathway_count": 2,
        "publication_count": 68,
        "publication_id_list": "10.1101/2023.09.13.557529;10857748;11062501;11350924;12646216;14734113;15224091;15224092;15531880;15571818;15746103;16227581;16595681;16849449;16954532;18662542;19028597;19352404;19452197;19489725;19651622;19851334;19874575;19940261;20068231;20166139;2261476;23301498;23481700;25418920;25860612;27920218;28228285;28904123;29242379;29314611;29789417;30315122;31020640;31154438;31844290;31937595;31998317;32157095;32161166;32350084;32387766;32897882;32938616;32983136;33298915;33316896;33717175;33912179;33968037;34087483;34171305;34357683;34509645;34932366;35051231;35154160;35251023;35580925;36215666;37316325;9380723;9668046",
        "class_list": "",
        "function": "Non-catalytic component of the KPC complex, a E3 ubiquitin-protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1 (PubMed:15531880, PubMed:15746103, PubMed:16227581, PubMed:25860612). The KPC complex catalyzes polyubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (PubMed:15531880, PubMed:15746103). The KPC complex also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B by catalyzing ubiquitination of the NFKB1 p105 precursor (PubMed:25860612). Within the KPC complex, UBAC1 acts as an adapter that promotes the transfer of target proteins that have been polyubiquitinated by RNF123/KPC1 to the 26S proteasome (PubMed:16227581)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; UBAC1/KPC2 Regulates TLR3 Signaling in Human Keratinocytes through Functional Interaction with the CARD14/CARMA2sh-TANK Complex. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75500;Q9UMW7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding;GO:0070628 proteasome binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0000151 ubiquitin ligase complex",
        "go_biological_process": "GO:0016567 protein ubiquitination;GO:0051604 protein maturation;GO:0019941 modification-dependent protein catabolic process;GO:0051726 regulation of cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 7.3,
        "record_id": "Q9BSL1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P62987-1",
        "uniprot_id": "RL40_HUMAN",
        "mass": 14728.0,
        "length": 128,
        "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein",
        "gene_name": "UBA52",
        "organism": "Human",
        "refseq_name": "ubiquitin-ribosomal protein eL40 fusion protein isoform 1 precursor",
        "refseq_ac": "NP_001029102",
        "gene_names_uniprotkb": "UBA52; UBCEP2",
        "gene_names_refseq": "CEP52; HUBCEP52; L40; RPL40; UBA52",
        "protein_names_uniprotkb": "Ubiquitin-ribosomal protein eL40 fusion protein; 60S ribosomal protein L40; CEP52; Ubiquitin A-52 residue ribosomal protein fusion product 1; rpL40",
        "protein_names_refseq": "ubiquitin carboxyl extension protein 52; ubiquitin-52 amino acid fusion protein; ubiquitin-60S ribosomal protein L40; ubiquitin-CEP52; ubiquitin-ribosomal protein eL40 fusion protein isoform 1 precursor; ubiquitin-ribosomal protein eL40 fusion protein",
        "tax_id": 9606,
        "disease": "colon carcinoma (Disease Ontology:DOID:1520)",
        "pathway": " (hsa:7311);  (R-HSA-110312);  (R-HSA-110314);  (R-HSA-110320);  (R-HSA-1169091);  (R-HSA-1169408);  (R-HSA-1234176);  (R-HSA-1236382);  (R-HSA-1236974);  (R-HSA-1253288);  (R-HSA-1295596);  (R-HSA-1358803);  (R-HSA-156827);  (R-HSA-156902);  (R-HSA-162588);  (R-HSA-168638);  (R-HSA-168927);  (R-HSA-168928);  (R-HSA-174048);  (R-HSA-174084);  (R-HSA-174113);  (R-HSA-174154);  (R-HSA-174178);  (R-HSA-174184);  (R-HSA-174490);  (R-HSA-175474);  (R-HSA-179409);  (R-HSA-1799339);  (R-HSA-180534);  (R-HSA-180585);  (R-HSA-182971);  (R-HSA-187577);  (R-HSA-192823);  (R-HSA-195253);  (R-HSA-201681);  (R-HSA-202424);  (R-HSA-205043);  (R-HSA-209543);  (R-HSA-209560);  (R-HSA-211733);  (R-HSA-2122947);  (R-HSA-2122948);  (R-HSA-2173788);  (R-HSA-2173791);  (R-HSA-2173795);  (R-HSA-2173796);  (R-HSA-2408557);  (R-HSA-2467813);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559585);  (R-HSA-2565942);  (R-HSA-2644606);  (R-HSA-2672351);  (R-HSA-2691232);  (R-HSA-2871837);  (R-HSA-2894862);  (R-HSA-2979096);  (R-HSA-3134975);  (R-HSA-3322077);  (R-HSA-349425);  (R-HSA-3769402);  (R-HSA-3785653);  (R-HSA-382556);  (R-HSA-445989);  (R-HSA-450302);  (R-HSA-450321);  (R-HSA-450408);  (R-HSA-4608870);  (R-HSA-4641257);  (R-HSA-4641258);  (R-HSA-4641263);  (R-HSA-5205685);  (R-HSA-532668);  (R-HSA-5357905);  (R-HSA-5357956);  (R-HSA-5358346);  (R-HSA-5362768);  (R-HSA-5607761);  (R-HSA-5607764);  (R-HSA-5610780);  (R-HSA-5610783);  (R-HSA-5610785);  (R-HSA-5632684);  (R-HSA-5654726);  (R-HSA-5654727);  (R-HSA-5654732);  (R-HSA-5654733);  (R-HSA-5655862);  (R-HSA-5656121);  (R-HSA-5656169);  (R-HSA-5658442);  (R-HSA-5668541);  (R-HSA-5675221);  (R-HSA-5675482);  (R-HSA-5676590);  (R-HSA-5678895);  (R-HSA-5684264);  (R-HSA-5685942);  (R-HSA-5687128);  (R-HSA-5689603);  (R-HSA-5689877);  (R-HSA-5689880);  (R-HSA-5689896);  (R-HSA-5689901);  (R-HSA-5693537);  (R-HSA-5693565);  (R-HSA-5693607);  (R-HSA-5696394);  (R-HSA-5696395);  (R-HSA-5696397);  (R-HSA-5696400);  (R-HSA-6781823);  (R-HSA-6781827);  (R-HSA-6782135);  (R-HSA-6782210);  (R-HSA-6783310);  (R-HSA-6791226);  (R-HSA-6804756);  (R-HSA-6804757);  (R-HSA-6804760);  (R-HSA-6807004);  (R-HSA-68867);  (R-HSA-68949);  (R-HSA-69017);  (R-HSA-69231);  (R-HSA-69481);  (R-HSA-69541);  (R-HSA-69601);  (R-HSA-72689);  (R-HSA-72706);  (R-HSA-72764);  (R-HSA-75815);  (R-HSA-8849469);  (R-HSA-8852276);  (R-HSA-8854050);  (R-HSA-8856825);  (R-HSA-8856828);  (R-HSA-8863795);  (R-HSA-8866427);  (R-HSA-8866652);  (R-HSA-8866654);  (R-HSA-8875360);  (R-HSA-8876493);  (R-HSA-8939236);  (R-HSA-8939902);  (R-HSA-8941858);  (R-HSA-8948747);  (R-HSA-8948751);  (R-HSA-8951664);  (R-HSA-901032);  (R-HSA-9010553);  (R-HSA-9013507);  (R-HSA-9013973);  (R-HSA-9014325);  (R-HSA-9020702);  (R-HSA-9033241);  (R-HSA-909733);  (R-HSA-912631);  (R-HSA-917729);  (R-HSA-917937);  (R-HSA-936440);  (R-HSA-936964);  (R-HSA-937039);  (R-HSA-937041);  (R-HSA-937042);  (R-HSA-937072);  (R-HSA-9604323);  (R-HSA-9613829);  (R-HSA-9615710);  (R-HSA-9633012);  (R-HSA-9636383);  (R-HSA-9637628);  (R-HSA-9645460);  (R-HSA-9646399);  (R-HSA-9648002);  (R-HSA-9664873);  (R-HSA-9680350);  (R-HSA-9683683);  (R-HSA-9692916);  (R-HSA-9694493);  (R-HSA-9705462);  (R-HSA-9705671);  (R-HSA-9706369);  (R-HSA-9706377);  (R-HSA-9708530);  (R-HSA-9725370);  (R-HSA-975110);  (R-HSA-975144);  (R-HSA-975163);  (R-HSA-9755511);  (R-HSA-9758274);  (R-HSA-975956);  (R-HSA-975957);  (R-HSA-9762114);  (R-HSA-9766229);  (R-HSA-9770562);  (R-HSA-977225);  (R-HSA-9824878);  (R-HSA-9828211);  (R-HSA-983168);  (R-HSA-9833109);  (R-HSA-9861718);  (R-HSA-9918432);  (R-HSA-9918487);  (R-HSA-9929356);  (R-HSA-9929491);  (R-HSA-9931269);  (R-HSA-9931295);  (R-HSA-9932298);  (R-HSA-9954709);  (R-HSA-9954714);  (R-HSA-9954716);  (R-HSA-9956593);  (R-HSA-9958810);  (R-HSA-9958825)",
        "pathway_count": 216,
        "publication_count": 3453,
        "publication_id_list": "10022869;10022904;10022913;10023660;10066435;10075690;10079256;10085068;10085069;10089880;10092233;10097102;10097139;10187770;10196136;10197981;10198061;10199400;10205060;10206645;10206983;10207050;10215629;10216106;10224040;10228156;10230406;10319874;10321728;10323868;10329646;10339564;10347217;10358005;10358095;10375532;10383417;10385526;10385618;10391242;10391953;10395669;10406800;10409699;10411507;10411933;10415025;10421629;10432220;10433824;10435622;10436022;10444327;10470034;10484077;10485843;10490027;10491388;10499802;10500146;10514377;10514424;10514433;10518217;10519551;10521396;10526214;10531062;10535736;10535940;10535941;10536157;10542231;10542297;10548110;10549281;10549282;10550055;10551863;10556217;10559216;10559856;10559861;10559916;10559924;10562279;10564087;10564661;10567358;10570149;10572046;10581160;10583407;10587642;10587654;10593898;10597293;10604467;10608892;10613896;10625686;10642508;10652316;10659855;10660610;10665657;10667208;10669729;10673331;10673500;10673501;10679238;10693759;10694380;10698680;10702308;10702393;10702794;10706082;10706887;10710310;10713164;10716940;10720933;10722742;10723127;10724175;10733526;10734143;10747026;10748049;10757792;10757800;10760286;10766245;10766823;10767424;10769163;10772813;10779524;10788335;10797013;10801132;10802669;10811609;10823831;10827953;10830164;10831586;10831588;10837247;10838074;10854325;10856253;10859164;10866324;10871633;10877843;10878807;10879540;10882063;10882101;10884341;10884347;10887153;10887178;10898789;10911365;10915768;10918611;10921920;10929008;10934142;10934472;10944113;10944529;10944533;10953014;1095581;10956649;10958687;10959836;10964718;10966113;10970870;10973490;10973499;10975528;10980695;10980696;10982817;10982836;10982844;10983987;10984056;10984059;10995389;11006133;11006276;11007478;11007770;11013220;11018020;11018027;11024059;11025670;11027307;11029007;11032757;11035045;11038283;11044625;11046155;11053425;11053437;11057907;11058110;11060040;11062501;11069780;11071885;11073976;11073981;11076969;11080452;11081627;11081636;11082038;11082044;11087742;11090634;11092454;11094434;11095724;11098060;11101887;11110708;11112487;11114305;11114888;11120601;11125146;11139606;11141066;11146634;11157743;11157749;11158290;11158580;11163210;11171333;11181075;11182090;11196150;11226752;11231140;11231573;11231585;11234019;11237011;11238463;11239454;11239457;11239468;11239472;11244088;11247302;11248027;11259415;11262391;11265756;11274402;11278251;11278841;11278856;11279012;11279143;11280786;11285280;1128706;11292861;11292862;11297579;11298456;11301010;11310834;11323407;11323434;11325957;11331269;11337497;11340163;11350924;11357136;11358837;11358993;11359766;11371342;11376695;11377645;11389444;11390408;11390642;11401442;11404376;11416152;11424093;11427533;11427719;11447115;11447225;11448771;11454738;11454741;11460167;11461910;11463333;11463336;11467836;11470803;11485998;11486055;11487608;11493532;11493923;11504826;11504915;11504942;11509732;11511361;11511362;11511374;11516654;11517213;11518718;11520989;11527981;11532962;11532990;11544179;11546806;11546814;11546874;11551508;11551930;11562349;11562789;11563910;11564866;11566882;11571274;11573085;11577081;11577110;11584266;11585831;11585840;11585916;11585921;11588175;11588219;11590439;11598268;11606584;11677247;11687798;11691915;11691921;11698404;11719808;11726970;11733065;11734858;11739726;11739732;11740489;11740563;11740940;11741535;11742988;11751994;11772397;11780126;11781871;11782450;11784855;11788588;11804587;11812794;11823422;11823423;11842200;11842292;11847229;11850821;11861489;11877457;11877461;118839;11883935;11884229;11884610;11889126;11893489;11894095;11894096;11904382;11904445;11917024;11919637;11922599;11923872;11927540;11927591;11931631;11931757;11934988;11943732;11956057;11960000;11960013;11961546;11964406;11970895;11983168;11988742;11988758;11997436;12000792;12019269;12024036;12024216;12029096;12050117;12050670;12057195;12064478;12068298;12068309;12070128;12070292;12072436;12080057;12086608;12101228;12112524;12114544;12118249;12123571;12133942;12134156;12136087;12138125;12145188;12145297;12150911;12150994;12151385;12152085;12167698;12171911;12185581;12186903;12189133;12193592;12194817;12198130;12205098;12207013;12208738;12209127;12213833;12218189;12221107;12223464;12226657;12234920;12234927;12234931;12239347;12242293;12244174;12297295;12351678;12353037;12354787;12364337;12364621;12379217;12379510;12391150;12391162;12393854;12393879;12399544;12403779;12408824;12408825;12411582;12417715;12419216;12421820;12424201;12426310;12429842;12433685;12435631;12435635;12444249;12444543;12446569;12446674;12447390;12447393;12451172;12453412;12454989;12456682;12464600;12473183;12473184;12475979;12482991;12485996;12493757;12496252;12504025;12504026;12514169;12519765;12525615;12526791;12527755;12530964;12538644;12538665;12545175;12546821;12551915;12554650;12554878;12559034;12578380;12578958;12582176;12583813;12584190;12588972;12593795;12593796;12600938;12604685;12607003;12607005;12609980;12609982;12615973;12627230;12646216;12646235;12660172;12660731;12663786;12667451;12676583;12676925;12682069;12686592;12692549;12697768;12700136;12702766;1270801;12709429;12712206;12717447;12717448;12718880;12724779;12727204;12732143;12738770;12750159;12750368;12750467;12759351;12759363;12759408;12766484;12773400;12787671;12788921;12791267;12791687;12791985;12791997;12792649;12796777;12800156;12808055;12808096;12815057;12815074;12816948;12819195;12820959;12821933;12832462;12832467;12832468;12832489;12842042;12847086;12851404;12853446;12853463;12860405;12881521;12882960;12885776;12890688;12893276;12907679;12912907;12913004;12914926;12915405;12917425;12917689;12917691;12920229;12923053;12934099;12944386;12944396;12952891;12952949;12953056;12958161;12958364;12958597;12963847;12974390;13130464;1317852;1334462;1352877;1356264;1359686;13678582;1377674;1379744;1400365;1423597;14505571;14506261;14507994;14512302;14514672;14517266;14517278;14517290;14517297;14517306;14527413;14528300;14528312;14532106;14532330;14555962;14555995;14560035;14561760;14564014;14567678;14567914;14567916;14576433;14576842;14581451;14584882;14585973;14597415;14600025;14603323;14611647;14617351;14622578;14622579;14624836;14625308;14630918;14633987;14634667;14636577;14636582;14657019;14657033;14657501;14660603;14660651;14661020;14661924;14662753;14672932;14673179;14675537;14676825;14679213;14681206;14684739;14685266;14688281;14690597;14695475;14701756;14702041;14703513;14707141;14716293;14718169;14718519;14724641;14726597;14729966;14734113;14742321;14742663;14749727;14757770;14764894;14769151;14960584;14962911;14966563;14973490;14980219;14981260;14985334;15001581;15010458;15014503;15021893;15024054;15029244;15031289;15034551;15037765;15044468;15044642;15047845;15053879;15053880;15064394;15064416;15064760;15075231;15075292;15084453;15084608;15100235;15104674;15105418;15107403;15107455;15115751;15117950;15118073;15118125;15122200;15123609;15125833;15131269;15132997;15134832;15138260;15140882;15145317;15147738;15147878;15149598;15150273;15163793;15169778;15169888;15175422;15189136;15189446;15190204;15198976;15199127;15199159;15201052;15201865;15208624;15208637;15208656;15210742;15215855;15215856;15218037;15220921;15224091;15224092;15226418;15247232;15252009;15254543;15257295;15258597;15260957;15279782;15280044;15282312;15284455;15287722;15292211;15300262;15312780;15317934;15318163;15318165;15324302;15327769;15327770;15329413;15334086;15339664;15340381;1535555;1535557;15358861;15361859;15361868;15362974;15367669;15371334;15374880;15385533;15389287;15448695;15449939;15451670;15454084;15459103;15465037;15465819;15466860;15469821;15469984;15472518;15473838;15473846;15474027;15475003;15475561;15485925;15492225;15492226;15496141;15496460;15502812;15502813;15504734;15505377;15509564;15525529;15525938;15531878;15533827;15534230;15537541;15538386;15539407;15541657;15545321;15546612;15546618;15548653;15563468;15564375;15565158;15569487;15571818;15572677;15572695;15572696;15574592;15574878;15577943;15579463;15588951;15590680;15601820;15601839;15611333;15613341;15620648;15637081;15649145;15652348;15652483;15652751;15657443;15659645;15664191;15664193;15671180;15678106;15678131;15683364;15688063;15694336;1570011;15701692;15702989;15703179;15703209;15707391;15713668;15721257;15728179;15735151;15735756;15737063;15760269;15761148;15767370;15774718;15775988;15778223;15778442;15781252;15781449;15781469;15788536;15799966;15802264;15811629;15814722;15820681;15821744;15824097;15828871;15829515;15837794;15845454;15851477;15855052;15858711;15863492;15866171;15866172;15870263;15882621;15895073;15895077;15899824;15916532;15916957;15916959;15916963;15917222;15917247;15919655;15930137;15937478;15962011;15962837;15964821;15965470;15983046;15987702;16000296;16009940;16024644;16026328;16027725;16030353;16037817;16043511;16043514;16055502;16056267;16061177;16061793;16093323;16103228;16109882;16112642;16113677;16115867;16115877;16116452;16122702;16125763;16127453;16136078;16139798;16140942;16142244;16143108;1614537;16148040;16150728;16153455;16153868;16153896;16155214;16156666;16159959;16161041;16163388;16168377;16170336;16171779;16171819;16174740;16186820;16186825;16187797;16195327;16209941;16209946;16211008;16214042;16215232;16219661;16223728;16227611;16246722;16252004;16252010;16256737;16260493;16260783;16274220;16278212;16280981;16282325;16282375;16284618;16284625;16286508;16289117;16301747;16303288;16306936;16306937;16307923;16319104;16322561;16326391;16327781;16335952;16337592;16337601;16341139;16344468;16352599;16356853;16356855;16356856;16357261;16357527;16359182;16360315;16360641;16371348;16371461;16371649;16377563;16377569;16394098;16401342;16402859;16407072;16407192;16407834;16410077;16413484;16415881;16421188;16421275;16427009;16428300;16431915;16436515;16443603;16446366;16452507;16459297;16459298;16459302;16460808;16469117;16473935;16474402;16478641;16479008;16483930;16491090;16510471;16510874;16516836;16530042;16530044;16531995;16543144;16547496;16547521;16547522;16551619;16554443;16556936;16595681;16601204;16603398;16611729;16611981;16611994;16612002;16622410;16626623;16630668;16630834;16647857;16648845;16651405;16651542;16678110;16682944;16684964;16687519;16699525;16705181;16707488;16707496;16715065;16723543;16723738;16728642;16732330;16738141;16738327;16738328;16740475;16751101;16751102;16751180;16753179;16764984;16773578;16775314;16777603;16782892;16790436;16798879;16799559;16806191;16813530;16815975;16816140;16819516;16824194;16825495;16826196;16829951;16829952;16831874;16845383;16849430;16849449;16849543;16850186;16854980;16868077;16871283;16872604;16880396;16884355;16884718;16885023;16890155;16892053;1689311;16893902;16901786;16901789;16903783;16906146;16914094;16916645;16931761;16939498;16943200;16943440;16953218;16953224;16954532;1695717;16962933;16964248;16969069;16971168;16971392;16973552;16973613;16978534;16980583;16987978;16989641;17000769;17003037;17007944;17018281;17028573;17035307;17035995;17043239;17047224;17053788;17072321;17081101;17086210;17092340;17097642;17108083;17108107;17108971;17110436;17114293;17115028;17121812;17126548;17128255;17130289;17132228;17135271;17139257;17141195;17142313;17157040;17158449;17158794;17161475;17170761;17177598;17178829;17182618;17183061;17183367;17187060;17189298;17202354;17204608;17210635;17210787;17218260;17218261;17218525;17220875;17234765;17234884;17251292;17254966;17254967;17254968;17255097;17255109;17267404;17267500;17270291;17283082;17289582;17289916;17290000;17290220;17303577;1730654;17314102;17318175;17327220;17332328;17332741;17344414;17349580;17349958;17351669;17352659;17353269;17353907;17360967;17363902;17363904;17363905;17372273;17376915;17381423;17392790;17395714;17395884;17400545;17401372;17412287;17412408;17412698;17412707;17416736;17425515;17428801;17434750;17438144;17442700;17443180;17446348;17448995;17452316;17456551;17460694;17463226;17466625;17466626;17468049;17475912;17483340;17485488;17486091;17494869;17496917;17497243;17507369;17507410;17510063;17510365;17512409;17512459;17517887;17522231;17523162;17525332;17525340;17526488;17540576;17548359;17553757;17562858;1756723;17575048;17580304;17580310;17591690;17591695;17592128;17596301;17597759;17599067;17600090;17609109;17625570;17627624;17636564;17641202;17644308;17646408;17646409;17646646;17652161;17662939;17675297;17681183;17681954;17686471;17696782;17698607;17699613;17699773;17702576;17707232;17707234;17712310;17713526;17720710;17724343;17726030;17726049;17728103;17728323;17761676;17762867;17765224;17765681;17785452;17785525;17786208;17803942;17804805;17823124;17825402;17846173;17848578;17855752;17873522;17875931;17875933;17878161;17881003;17882165;17890055;17893241;17894550;17908796;17928296;17938197;17947239;17948050;17948053;17965729;17969444;17977821;17978091;17979524;17980597;17981138;17981804;17991829;17993263;17997719;18000046;18001824;18001825;18003979;18006705;18031682;18032517;18035202;18039658;18040046;18043734;18057259;18063579;18065403;18065497;18066079;18070875;18070888;18070982;18077395;18077452;18077588;18079694;18079701;18082604;18093314;18093523;18094723;18097461;18162290;18166647;18166656;18167338;18171670;18172164;18174376;18178551;18180283;18182391;18184961;18192505;18194661;18199536;18199683;18200010;18206966;18230761;18235225;18237417;18238777;18242152;18248330;18256688;18264092;18267069;18273910;18280240;1828071;18281465;18282684;1828392;1828393;1828394;18285520;18287095;18288197;18294816;18296446;18305167;18307765;18310267;18316726;18327259;1833184;18332145;18337469;18342608;18347055;18353650;18359941;18365017;1837051;18374639;18374649;18378692;18378770;18387606;18388313;18400985;1840698;18411265;18414028;18417469;18418349;18423202;18423204;18426978;18434309;18438411;18438418;18443292;18447580;18447585;18449172;18449189;18452557;18455985;18455992;18456656;18462684;18462924;18467330;18467591;18469519;18474358;18477460;1847920;18480045;18484335;18485873;18490454;1849145;18497258;18497827;18502753;18502828;1850507;18508966;18515281;18521620;18524595;18524852;18534984;18539146;18541707;18547165;18555777;18555778;1856230;18566290;18568018;18570872;18573886;18573912;18575461;18583345;18591409;18593892;18593949;18594010;18598779;18599482;18614043;18615013;1861871;18624796;18628966;18632802;18632848;18635759;18636086;18644861;18644862;18644871;18653540;18657639;18662336;18662542;18692471;18698078;18700817;18701132;18701449;18710948;18710949;18711132;18712838;18716059;18716620;18719096;18719106;18720373;18724359;18724360;18724939;18758443;18772140;18775313;18775314;18776931;18790740;18793328;18805091;18805092;18819912;18819921;18819930;18824583;18824585;18826954;18827223;18827403;18832070;18833288;18851830;18923075;18923523;18923524;18923525;18926707;18931676;18971343;18974281;18981233;18985070;18997792;18997794;19000840;19000841;19001859;19002207;19011241;19011621;19015242;19017631;19022706;19028597;19047045;19047365;19054389;19056373;19056823;19060897;19061640;19066035;19073728;19074197;19075005;19081070;19084021;19091743;19092055;19092802;19106111;19109251;19109893;19111657;19112497;19117993;19121998;19122653;19125153;19125156;19135894;19140243;19150429;19151708;19153159;19153606;19158341;19166925;19170759;19176521;19188362;19188440;19193720;19193793;19197237;19202061;19203578;19203579;19208625;19208626;19208840;19217269;19217410;19234442;19250909;19250911;19261749;19264966;19270716;19276253;19278658;19279666;19287005;19289468;19296720;19305393;19307298;19321346;19332556;19345329;19346256;19351884;19352404;19357644;19359157;19359218;19363159;19364920;19368795;19371734;19379695;19380580;19380724;19383985;19387438;19398035;19398555;19398892;19410543;19416807;19417104;19419957;19424180;19432818;19447222;19451217;19451218;19452197;19453968;19456272;19458076;19458185;19459784;19462008;1946430;19464428;19473979;19473982;19478851;19484123;19487459;19487573;19489725;19492058;19503078;19513348;19520913;19524514;19527882;19528227;19531363;19533801;19535145;19536138;19549984;19556969;19560417;19561358;19564402;19567869;19570978;19573811;19575674;19584060;19589784;19590513;19592253;19593530;19596236;19603039;19603532;19608861;19608919;19609301;19617556;19619488;19620632;19622347;19632994;19652666;19658395;19661379;19666503;19675569;1968060;1968359;19684112;19690147;19696444;19696796;19696798;19699667;19706539;19713939;19713942;19723507;19726682;19729658;19732400;19734889;19748355;19754430;19756449;19758997;19759537;19762596;19762597;19776351;19782031;19801658;19805069;19808967;19808995;19809571;19814798;19815541;19815555;19816404;19818707;19818708;19828817;19838211;19851334;19852954;19853559;19859661;19862647;19874575;19874889;19878745;19881509;19893624;19896182;19897490;19898473;19900460;19903815;19909264;19909372;19910467;19914168;19917253;19928349;19933325;19934406;19935683;19940019;19940136;19940261;19941824;19941829;19953639;19955409;19965871;1998343;19995904;19996094;19996169;20004982;20005846;20008555;20014402;20016067;20016603;20018861;20023408;20023648;20033049;20033059;20038530;20038579;20047764;20056613;20059951;20061380;2006156;20080666;20096447;20098737;20100835;20102227;20104595;20107323;20117945;20118233;20126261;20129061;20129063;20130243;20133869;20154143;20154705;20156974;20159558;20159559;20164194;20178365;20185725;20193029;20211604;20219915;20219937;20223231;20227366;20227374;20228808;20231386;20233725;20236090;20300203;20304918;20308324;20332238;20347428;20347429;20348946;20351096;20351172;20351173;20357282;20360384;20361218;20363976;20368362;20368735;20378532;20385093;20385554;20385878;20388639;20388916;20403326;20409569;20416930;20418879;20427281;20428113;20434986;20436459;20438709;20444697;20448150;20449947;20452968;20452972;20454865;20460306;20466723;20479275;20487519;20489731;20495340;20495530;20501646;20501935;20512148;20525693;20531386;20534573;20536836;20538596;20538597;20538786;20541997;20543837;20550936;20553488;20554524;20577264;20583968;20585641;20595680;20603015;20603016;20603073;20606012;20621639;20622895;20628368;20643137;20643644;20660785;20663872;20670894;20671156;20676056;20685844;20691628;20695905;20712405;20713061;20734105;20797626;20798176;20802526;20805244;20805357;20807650;20817927;20818436;20819938;20826345;20843055;20844016;20849292;20855601;20858899;20870725;20876134;20887958;20889716;20930030;20937913;20940148;20946875;20952260;20952511;20956384;20959462;20966255;20966921;20972443;21029861;21036871;21040849;21049007;21052091;21063389;21070792;21072051;21074459;21081755;21083385;21091114;21095583;21097556;21102408;21115803;21134980;21135142;21143968;21145460;2115402;21164297;21170358;21177870;2118650;21187331;21194381;21203937;21213368;2121370;21220506;21235526;21238931;21239494;21240188;21245377;21252624;21257310;21258369;21262971;21263215;21273557;21278753;21282113;21282463;21282471;21289126;21293379;21295486;21316588;21317288;21317932;21325134;21329875;21329877;21329882;21335549;21335604;2135388;21356517;21357747;21362556;21372320;21376233;21383061;21388382;21391649;2139180;21396873;21408173;21415216;21419344;21423214;21445324;21447816;21463634;21464321;21478859;2147937;21482805;21494621;21499258;21525931;21527911;21532586;2154449;21554508;21571218;21571647;21596315;21596819;21613550;21617041;21625555;21628590;21632553;21632562;21652558;21656749;21659512;21659603;21661760;21680713;21693646;21695114;21701511;21703539;21715330;21727895;21730132;21730163;21734303;21734707;21737330;21757351;21764741;21777809;21778237;21779028;21779496;21779505;21791603;21799911;21801010;2183031;21838707;21841790;21847362;21849505;21862579;21862588;21863050;21875946;21878643;21883765;21905185;21905186;21909076;21921029;21927000;21927001;21931591;21931630;21940857;2195544;2196173;21962517;21962518;21966355;21976670;21979375;21980954;21983142;21984732;21986495;21995445;22000013;22000856;22002062;22002721;22002868;22007132;22012064;22014570;22020331;22021381;22021426;22024395;22029577;22036506;2204156;22045334;22046132;22047557;22057399;22065755;22069318;22072790;22081108;22085928;22099461;22101459;2210768;2211721;22117219;22118460;22118466;22124327;22128162;22131221;22142471;22144181;22153078;22153499;22162134;22178396;22178883;22179043;22179575;22190735;22195017;22195972;22216260;22231403;22233676;22234877;22248338;22249260;22253733;22258451;22265677;22267219;22275377;22279049;22286099;22287633;22297296;22304967;22306028;22306998;22312431;22318583;22323579;22325352;22327622;22336108;22344298;22347464;22357968;2236053;22362889;22365832;22371489;22373579;22374676;22383950;22388039;22391301;22396592;22411803;22422618;22427670;22435550;22438257;22440753;22466610;22466611;22466612;22466964;22483114;22484487;22499340;22505454;22505844;22508508;22508986;22510687;22510808;22537386;22570254;22575959;2257624;22589270;22589545;2261476;22634325;22635276;22641346;22645359;22653731;22658521;22658935;22658936;22661229;22661230;22681887;22683641;22692201;22700975;22718757;22721435;22721555;22729708;22730326;22745133;22747494;22751498;22751928;22761442;22762019;22772988;22773843;22773952;22789539;22792074;22798961;22800433;22802525;22813749;22815132;22815487;22848449;22859295;22859296;22863004;22872865;22885700;22897851;22902626;22902628;22908299;22916032;22936343;22941947;22942183;22942912;22946059;22952242;22959436;22964642;22977173;22980979;22982193;2298749;22988300;23000554;23000965;23007395;23038248;23042605;23042607;23045548;23061660;23063411;23069990;23085078;23104988;23105109;23112049;23112050;23121362;23139213;23140627;23143872;23144924;23159851;23169626;23201271;23201355;23208509;2321095;23217742;23222971;23230144;23232094;23234702;23236459;23239810;23246432;23256519;23266279;23269699;23274085;23297414;23300935;23305486;23313255;23319653;23325218;23332756;23333304;23333871;23345434;23352614;23352696;23395819;23401859;23403054;23419514;23439679;23443682;23452856;23453757;23453969;23453971;23453972;23468639;23482395;23483519;23485397;23486064;23514631;23515720;23516580;23535009;23535662;23535663;23536704;23548639;23563313;23579495;23583660;23593430;23603117;23613522;23615448;23616951;23622515;23636399;23661334;23661552;23663739;23676219;23685075;23686288;23698361;23698467;23707526;23719536;23723247;23725801;23731732;23737759;23746841;23746843;23751493;23791946;23813966;23823722;23824326;23825189;23827681;23846687;23847203;23851460;23856247;23861397;23867461;23874216;23878308;2388630;23891661;23906714;23912815;23943595;23943869;23955340;23957430;23963456;23973375;23986495;24011591;24019521;24033119;24035498;2405250;24056413;24060861;24072710;24074955;24076191;24076221;24076655;2409350;24098568;24127601;24130457;24145406;24149845;24186068;24200693;24235149;24246475;24260525;24270891;24291232;24298019;24302888;24309468;24323043;24366543;24367090;24384571;24389026;24402227;24417533;24424021;24445538;24449906;24475247;24485656;24493797;24496003;24509444;24515438;24518094;24523872;24524803;24550520;24581490;24582806;24585635;24610782;24613930;24622840;24623813;24636985;24648516;24660806;24662292;24667604;24680432;24685677;24705897;24706756;2472219;24725411;24726323;24726325;24726327;24736082;24746795;24751536;24755855;2475911;24768535;24784582;24784881;24789820;24793695;24793696;24807418;24814062;24828152;24833601;24842903;24845016;24854014;24854174;24865970;24874608;24876129;24890514;24893886;24896179;24905007;24925320;24966051;24971579;24979766;25016021;25019382;25030448;25040165;25043025;25081058;25083866;25092655;25107275;25113031;25122754;25125655;25132172;25133187;25135833;25152365;25154395;25170678;25197364;25231993;25242263;25253721;25260729;25263444;25301780;25301781;25303366;25305019;2530630;25314029;25314968;25339975;25341920;25342631;25349211;25355947;25356553;25356737;25359607;2536303;25371710;25393796;25394790;25416783;25421750;25430771;25435140;25440060;25474007;25500724;25502872;25505266;25523424;25525153;25527291;25527497;25531226;25538220;25538232;25538239;25544560;25547115;25550383;25558984;25565632;25576301;25578727;25578875;25584290;25597358;25642820;25654763;25659039;2570070;2570460;25713064;25733683;25740432;25752573;25752577;25759176;25764917;25781681;25793262;25813404;25852146;25854684;25904330;25907116;25921060;25921531;25936802;25961502;25969445;25996294;26001147;26018760;26029847;26042225;26042670;26062823;26085527;26086376;26091038;26116755;26117325;26118642;26138649;26151477;26154972;26166760;26183061;26208004;26208431;26210183;26216881;26216882;26220973;26222030;26235028;26235645;26237581;26240016;26280083;26280536;26301689;26308771;26320399;26344099;26344566;26344709;26350214;26359375;26365381;26378163;26389808;26403691;26417681;26460955;26562072;26583321;26590425;2661017;26611529;26620909;26632597;26668317;26686862;26701913;26706195;26711259;26735137;26771141;26775703;26778333;26807092;2682646;26829388;26866270;26900751;26906416;26933192;26942676;26992070;26997266;27030794;27035970;27068951;27094677;27137657;27153775;27164085;27203180;27222660;27245569;27247382;27249176;27307491;27383988;27396271;27397612;27410739;27426725;27458164;27458237;27466718;27526673;27538435;27545878;27552911;27565346;27569044;27572267;27573755;27591049;27597759;27666490;27697864;27701768;27791178;27798111;27862975;27874193;279930;2799391;28065601;28071645;28086240;28096519;28115426;28132103;28132843;28148787;28154142;28167504;28228593;28278510;28317937;28380357;28404650;28467828;28506461;28521612;28525742;28593173;28611190;28611990;28630138;28659337;28661484;28666118;28685749;28741662;28765278;28778966;28787099;28790369;28904123;2890644;28911096;28920952;28920954;2898143;2900981;29024643;29055231;29117567;29144452;29153394;29186539;29233872;29274231;29294448;29311131;29356040;29394115;29413899;29424242;29450944;29455642;2946959;29526543;29557506;29577978;29626215;29632312;29642005;29717933;29765039;29856954;29856955;29873274;29880609;29883609;29883610;29911972;29930286;29995846;30111836;30118680;30131584;30139799;30146158;30185776;30244831;30257008;30293783;30315122;30334692;30334693;3035556;30361438;3037496;30397120;30410026;30420664;30455202;30484775;30485383;3053705;30558248;30610225;30692217;30700497;30711375;30728908;30770249;30804176;3080684;30833945;3094007;30988283;31011209;31031142;31034780;31066629;31131315;31138766;31216343;31217245;31231549;3129195;31305264;31356149;31358971;31366041;31366726;3142462;31511692;3153318;31543423;31546975;31679946;31735643;31826938;31844290;31848261;31850239;31936902;32005965;32032529;32099016;32113509;32119511;32157095;32161166;32265295;32284348;32293500;32296703;32320653;32330457;32350084;32353859;32355176;32357974;32387766;32428392;32502341;32511913;32574262;32579943;32589897;32640524;32661006;32669547;32672401;32726803;32728199;32758689;32816001;32862111;32877642;32890404;32897882;32938616;32953130;32979938;32981041;32983136;33009401;33024073;33043033;33060197;33091337;33097660;33110251;33117408;33123756;33141586;33189161;33193462;33298915;33349665;33360543;33372174;33372854;33392160;33396578;33396605;33402344;33406423;33440148;33444648;33462636;33469115;33479219;33495715;33514628;33537174;33567255;33592498;33654074;33691108;33717175;33718825;33723219;33723527;33727702;33791708;33801464;33807682;33849972;33859744;33895773;33909987;33912179;33936100;33963333;33968037;33981976;33989516;33990585;34021074;34054808;34084167;34087483;34093574;34110168;34162724;34166398;34171305;3417785;34215617;34239064;34239127;34290717;34315872;34341353;34357683;34363755;34375313;34400613;34439781;34452305;34471099;34502139;34509645;34561969;3457471;34597346;34671164;34696522;3472246;34876703;34932366;34999730;35008409;35051231;35102342;35154160;35177536;35215835;35251023;35318648;35385574;35561310;35580925;35585045;35643212;35941131;36010968;36172813;36198437;36215666;36241641;36302773;36624349;36719382;3675579;36936901;37051252;37217939;37340703;37371478;37451480;37676773;38177122;38287189;38445807;38793607;39048817;39103523;3941892;40596516;429297;4829444;5348606;5427280;592398;592399;6146630;6162102;6277905;6305978;641056;6548414;6568109;688397;6901506;7479848;7479976;7499357;7510216;7512451;7523390;7526154;7529176;7531702;7535770;7537377;7537740;7540766;7541030;7542744;7544915;7553863;7553864;7559382;7559393;7559638;7566092;7569928;7575604;7578059;7588063;7588608;7588633;7588753;7597091;7612269;7628694;7639698;7657591;7665160;7667287;7681396;7686617;7700386;7719337;7737969;7757881;7784084;7790377;7795595;7797074;7799959;7809113;7816143;7822302;7824924;7831327;7851534;7859739;7862124;7865904;7877694;7885476;7902568;7954814;7957050;7957109;7983023;7985023;7990965;8001118;8001816;8010951;803282;8033412;8041726;8041788;8078588;8078911;8097946;8107774;8112288;8114739;8114934;8139570;8140422;8159701;8168482;8197134;8232552;8234276;8246996;8259215;8313469;8319905;8327496;8332913;8336704;8336711;8355686;8383669;8384717;8387275;8407925;8413215;8413306;8464497;8479525;8490014;8493579;8497257;8521496;8524399;8533096;8533761;8544406;8550590;8552081;8552632;8553074;8563751;8599092;8601309;8601315;8605876;8613547;8617720;8621447;8621719;8622669;8622688;8625414;8626374;8626462;8626543;8626550;8631325;8633037;8638164;8649374;8649859;8658138;8662539;8662591;8662795;8670417;8672527;8687460;8688489;8689684;8692841;8695634;8702708;8702790;8706131;8741839;8751446;8774846;8809036;8824192;8824437;8837778;8837779;8846784;8858165;8870004;8876179;8884985;8887688;8890909;8896571;8921937;8939459;8944023;8954786;8972730;8974401;8981370;8991089;8995358;9006323;9030721;9037075;9038169;9042862;9049422;9054935;9065443;9090381;9090382;9090383;9092476;9096384;9100026;9106657;9108479;9121453;9122164;9130708;9135132;9135156;9136925;9144196;9151685;9162092;9168116;9169477;9190208;9195981;9200440;9207787;9207788;9211906;9215638;9219684;9225065;9230313;9233797;9242679;9244301;9247583;9252186;9259313;9302992;9303539;9315665;9315679;9325318;9326587;9334213;9335507;9346238;9346484;9346895;9362451;9371760;9372967;9380723;9384573;9391096;9395096;9427626;9428629;9430229;9430721;9431993;9436858;9447971;9448290;9461599;9462510;9482734;9482744;9488723;9501980;9506952;9508775;9520446;9521656;9525617;9525940;9528852;9529249;9535855;9535861;9539740;9544839;9564042;9566918;9571199;9575168;9590251;9590294;9593755;9601642;9604939;9620803;9628874;9631292;9635431;9635433;9637248;9651681;9652413;9653144;9659921;9660177;9660940;9662395;9668046;9668159;9674432;9687533;9691087;9694793;9699634;9700209;9705271;9712840;9716411;9719863;9721103;9723620;9730987;9736607;9742107;9744806;9744859;9747882;9768359;9771710;9771713;9790970;9810004;9812899;9816258;9819383;9819428;9822558;9824166;9831708;9837948;9844631;9847332;9851253;9856985;9859996;9861020;9862427;9864362;9865693;9874371;9875289;9885206;9887101;9891082;9892021;9914500;9915784;9925639;9931343;9950430;9989503;9990852;9990853",
        "class_list": "",
        "function": "Component of the 60S subunit of the ribosome (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Component of the 60S subunit of the ribosome., [UniProtKB, UniProtKB]; Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling., [UniProtKB, PubMed, PubMed, PubMed]; Inhibition of UBA52 induces autophagy via EMC6 to suppress hepatocellular carcinoma tumorigenesis and progression., [RefSeq, PubMed]; RPS27a and RPL40, Which Are Produced as Ubiquitin Fusion Proteins, Are Not Essential for p53 Signalling. Publication Status: Online-Only, [RefSeq, PubMed]; SMYD5 methylation of rpL40 links ribosomal output to gastric cancer., [RefSeq, PubMed]; UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair., [RefSeq, PubMed]; Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P02248;P02249;P02250;P14793;P62988;Q29120;Q6LBL4;Q6LDU5;Q8WYN8;Q91887;Q91888;Q9BWD6;Q9BX98;Q9UEF2;Q9UEG1;Q9UEK8;Q9UPK7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane",
        "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0036211 protein modification process;GO:0007283 spermatogenesis;GO:0016567 protein ubiquitination;GO:0006941 striated muscle contraction",
        "synthesized_glycan_count": 0,
        "hit_score": 345.6,
        "record_id": "P62987-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96E22-1",
        "uniprot_id": "NGBR_HUMAN",
        "mass": 33224.0,
        "length": 293,
        "protein_name": "Dehydrodolichyl diphosphate synthase complex subunit NUS1",
        "gene_name": "NUS1",
        "organism": "Human",
        "refseq_name": "dehydrodolichyl diphosphate synthase complex subunit NUS1",
        "refseq_ac": "NP_612468",
        "gene_names_uniprotkb": "NUS1; C6orf68; NGBR",
        "gene_names_refseq": "C6orf68; CDG1AA; MGC:7199; MRD55; NUS1; NgBR; TANGO14",
        "protein_names_uniprotkb": "Dehydrodolichyl diphosphate synthase complex subunit NUS1; 2.5.1.87; Cis-prenyltransferase subunit NgBR; NgBR; Nogo-B receptor; Nuclear undecaprenyl pyrophosphate synthase 1 homolog",
        "protein_names_refseq": "Nogo-B receptor; cis-prenyltransferase subunit NgBR; dehydrodolichyl diphosphate syntase complex subunit NUS1; dehydrodolichyl diphosphate synthase complex subunit NUS1; di-trans,poly-cis-decaprenylcistransferase; nuclear undecaprenyl pyrophosphate synthase 1 homolog; transport and golgi organization 14 homolog",
        "tax_id": 9606,
        "disease": "autosomal dominant intellectual developmental disorder 55 (Disease Ontology:DOID:0080227); congenital disorder of glycosylation Iaa (Disease Ontology:DOID:0080553); Parkinson's disease (Disease Ontology:DOID:14330); epilepsy (Disease Ontology:DOID:1826); congenital disorder of glycosylation (Disease Ontology:DOID:5212)",
        "pathway": " (hsa:116150);  (R-HSA-446199);  (R-HSA-4755609)",
        "pathway_count": 3,
        "publication_count": 80,
        "publication_id_list": "12213788;12591616;14652022;16835300;17273964;17764014;19723497;20637498;20700148;21295282;21295283;21572394;22240719;22424782;24714562;25066056;25576301;26154972;26375851;26992070;27600516;27846572;28218747;28228285;28832583;28834231;28842490;28904123;29100083;29242379;29393594;29437277;29493099;29508533;29557506;29632711;30315122;30410026;30429286;31154438;31844290;31848261;31998317;32157095;32161166;32387766;32488085;32817466;32897882;32983136;33077723;33392160;33592498;33633747;33717175;33798445;33912179;33968037;34211107;34326813;34357683;34509645;34561969;34635350;34932366;35051231;35580925;35584224;36010968;36241702;36284347;37249665;37938771;38520610;38821050;39894887;6243292;7374371;8626466;9294218",
        "class_list": "",
        "function": "Common Variants in NUS1 and GP2 Genes Contributed to the Risk of Gestational Diabetes Mellitus. Publication Status: Online-Only, [RefSeq, PubMed]; Identify a previously uncharacterized Nogo-B receptor specific for the amino terminus of Nogo-B, [RefSeq, PubMed]; In s-IBM muscle the Nogo-B increase may represent an attempt by muscle fiber to decrease A beta production. However, the increase of Nogo-B seems insufficient because A beta continues to accumulate and the disease progresses., [RefSeq, PubMed]; Low-frequency and rare coding variants of NUS1 contribute to susceptibility and phenotype of Parkinson's disease., [RefSeq, PubMed]; NUS1 Variants Cause Lennox-Gastaut Syndrome Related to Unfolded Protein Reaction Activation., [RefSeq, PubMed]; Nogo-B receptor (NgBR) is an essential component of the dolichol monophosophate (Dol-P) biosynthetic machinery. Loss of NgBR results in a robust deficit in cis-isoprenyltransferase (IPTase) activity and Dol-P production. Publication Status: Online-Only, [RefSeq, PubMed]; Nogo-B receptor increases glycolysis and the paclitaxel resistance of estrogen receptor-positive breast cancer via the HIF-1alpha-dependent pathway. Erratum:[Cancer Gene Ther. 2023 May;30(5):766. doi: 10.1038/s41417-022-00553-3. PMID: 36376422], [RefSeq, PubMed]; Novel NUS1 variant in a Chinese patient with progressive myoclonus epilepsy: a case report and systematic review., [RefSeq, PubMed]; The Nogo-B receptor localizes primarily to the endoplasmic reticulum and regulates the stability of nascent Niemann-Pick type C2 protein., [RefSeq, PubMed]; This gene encodes a type I single transmembrane domain receptor, which is a subunit of cis-prenyltransferase, and serves as a specific receptor for the neural and cardiovascular regulator Nogo-B. The encoded protein is essential for dolichol synthesis and protein glycosylation. This gene is highly expressed in non-small cell lung carcinomas as well as estrogen receptor-alpha positive breast cancer cells where it promotes epithelial mesenchymal transition. This gene is associated with the poor prognosis of human hepatocellular carcinoma patients. Naturally occurring mutations in this gene cause a congenital disorder of glycosylation and are associated with epilepsy. A knockout of the orthologous gene in mice causes embryonic lethality before day 6.5. Pseudogenes of this gene have been defined on chromosomes 13 and X. [provided by RefSeq, May 2017]., [RefSeq]; With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394). Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (PubMed:16835300)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RWQ4;O00251",
        "ec_number_list": "2.5.1.87;2.5.1.-",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0045547 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity",
        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:1904423 dehydrodolichyl diphosphate synthase complex",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0030154 cell differentiation;GO:0032383 regulation of intracellular cholesterol transport;GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis;GO:0038084 vascular endothelial growth factor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "Q96E22-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96KP6-1",
        "uniprot_id": "TNIP3_HUMAN",
        "mass": 38943.0,
        "length": 325,
        "protein_name": "TNFAIP3-interacting protein 3",
        "gene_name": "TNIP3",
        "organism": "Human",
        "refseq_name": "TNFAIP3-interacting protein 3 isoform 2",
        "refseq_ac": "NP_001122315",
        "gene_names_uniprotkb": "TNIP3; ABIN3; LIND",
        "gene_names_refseq": "ABIN-3; LIND; TNIP3",
        "protein_names_uniprotkb": "TNFAIP3-interacting protein 3; A20-binding inhibitor of NF-kappa-B activation 3; ABIN-3; Listeria-induced gene protein",
        "protein_names_refseq": "A20-binding inhibitor of NF-kappa-B activation 3; ABIN-3 beta; Listeria induced; TNFAIP3-interacting protein 3 beta; TNFAIP3-interacting protein 3 isoform 2; TNIP3 beta; listeria-induced gene protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79931);  (R-HSA-5689896)",
        "pathway_count": 2,
        "publication_count": 28,
        "publication_id_list": "10385526;11237011;11345586;11463333;14661020;15258597;15334086;17088249;17485448;18081698;18212736;19383985;19464428;19818707;19996094;20553488;22124327;23827681;24610782;25904330;26280536;29242379;29493099;31307045;31844290;32268115;32983136;33592498",
        "class_list": "",
        "function": "ABIN-3 is a novel negative feedback regulator of LPS-induced NF-kappaB activation, [RefSeq, PubMed]; ABIN-3 is, thus, an IL-10-induced gene product capable of attenuating NF-kappaB in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions., [RefSeq, PubMed]; Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding., [UniProtKB, PubMed]; Elevated TNIP3 mRNA Expression in TNF-alpha-Secreting Cells from Patients with Major Depressive Disorder., [RefSeq, PubMed]; Enhanced expression of ABIN-3 in monocytes is associated with sepsis, [RefSeq, PubMed]; TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1A574;A8K2Z4;B4DVF5;B4E023;Q96PQ3;Q9H780",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0071222 cellular response to lipopolysaccharide;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0034142 toll-like receptor 4 signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q96KP6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZSC3-1",
        "uniprot_id": "RBM43_HUMAN",
        "mass": 40666.0,
        "length": 357,
        "protein_name": "RNA-binding protein 43",
        "gene_name": "RBM43",
        "organism": "Human",
        "refseq_name": "RNA-binding protein 43",
        "refseq_ac": "NP_940959",
        "gene_names_uniprotkb": "RBM43; C2orf38",
        "gene_names_refseq": "C2orf38; RBM43",
        "protein_names_uniprotkb": "RNA-binding protein 43; RNA-binding motif protein 43",
        "protein_names_refseq": "RNA-binding protein 43",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:375287)",
        "pathway_count": 1,
        "publication_count": 34,
        "publication_id_list": "11237011;19413330;24714562;25576301;26375851;26728094;26992070;27397612;27600516;27846572;27862975;28218747;28832583;29242379;29437277;29493099;29557506;30429286;31154438;31530632;31844290;31848261;32157095;32350084;32387766;32632220;32983136;33592498;33717175;34171305;34357683;35051231;35580925;36284347",
        "class_list": "",
        "function": "RNA-binding motif protein 43 (RBM43) suppresses hepatocellular carcinoma progression through modulation of cyclin B1 expression., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RMT5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q6ZSC3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P49638-1",
        "uniprot_id": "TTPA_HUMAN",
        "mass": 31750.0,
        "length": 278,
        "protein_name": "Alpha-tocopherol transfer protein",
        "gene_name": "TTPA",
        "organism": "Human",
        "refseq_name": "alpha-tocopherol transfer protein isoform 1",
        "refseq_ac": "NP_000361",
        "gene_names_uniprotkb": "TTPA; TPP1",
        "gene_names_refseq": "ATTP; AVED; TTP1; TTPA; alphaTTP",
        "protein_names_uniprotkb": "Alpha-tocopherol transfer protein; Alpha-TTP",
        "protein_names_refseq": "alpha-TTP; alpha-tocopherol transfer protein isoform 1; tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E deficiency)",
        "tax_id": 9606,
        "disease": "familial isolated deficiency of vitamin E (Disease Ontology:DOID:0090028); liver benign neoplasm (Disease Ontology:DOID:916)",
        "pathway": " (hsa:7274);  (R-HSA-8877627)",
        "pathway_count": 2,
        "publication_count": 21,
        "publication_id_list": "12899840;14657365;15065857;15300460;16024914;25262571;26981194;29557506;32157095;34561969;34563650;35051231;35150738;38109176;7566022;7719340;7832785;7887897;7937827;8602747;9463307",
        "class_list": "",
        "function": "Alpha-Tocopherol transfer protein (alpha-TTP). Review article, [RefSeq, PubMed]; Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897). Binds both phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity)., [UniProtKB, PubMed]; Genetic heterogeneity within a consanguineous family involving TTPA and SETX genes., [RefSeq, PubMed]; The tocopherol transfer protein mediates vitamin E trafficking between cerebellar astrocytes and neurons., [RefSeq, PubMed]; This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa. [provided by RefSeq, Nov 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q71V64",
        "ec_number_list": "",
        "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0008431 vitamin E binding;GO:0120013 lipid transfer activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005770 late endosome",
        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009636 response to toxic substance;GO:0051180 vitamin transport;GO:0120009 intermembrane lipid transfer;GO:0042360 vitamin E metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "P49638-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IVU9-1",
        "uniprot_id": "CBCO1_HUMAN",
        "mass": 23883.0,
        "length": 208,
        "protein_name": "Ciliary-associated calcium-binding coiled-coil protein 1",
        "gene_name": "CABCOCO1",
        "organism": "Human",
        "refseq_name": "ciliary-associated calcium-binding coiled-coil protein 1 isoform 1",
        "refseq_ac": "NP_775825",
        "gene_names_uniprotkb": "CABCOCO1; C10orf107",
        "gene_names_refseq": "ARIEL; C10orf107; CABCOCO1",
        "protein_names_uniprotkb": "Ciliary-associated calcium-binding coiled-coil protein 1",
        "protein_names_refseq": "ARID5B-inducing enhancer associated long noncoding RNA; ciliary-associated calcium-binding coiled-coil protein 1 isoform 1; ciliary-associated calcium-binding coiled-coil protein 1; uncharacterized protein C10orf107",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:219621)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11237011;19430483;20542020;20852445;21045733;29557506;33141586",
        "class_list": "",
        "function": "Calcium-binding protein. May be involved in the control of sperm flagellar movement., [UniProtKB, UniProtKB]; Observational study and meta-analysis of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T1B8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0036126 sperm flagellum",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q8IVU9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P11926-1",
        "uniprot_id": "DCOR_HUMAN",
        "mass": 51148.0,
        "length": 461,
        "protein_name": "Ornithine decarboxylase",
        "gene_name": "ODC1",
        "organism": "Human",
        "refseq_name": "ornithine decarboxylase isoform 1",
        "refseq_ac": "NP_001274118",
        "gene_names_uniprotkb": "ODC1",
        "gene_names_refseq": "BABS; NEDBA; NEDBIA; ODC1; ODC",
        "protein_names_uniprotkb": "Ornithine decarboxylase; 4.1.1.17; ODC",
        "protein_names_refseq": "ornithine decarboxylase isoform 1",
        "tax_id": 9606,
        "disease": "atrichia with papular lesions (Disease Ontology:DOID:0060689); neurodevelopmental disorder with alopecia and brain abnormalities (MONDO:MONDO:0033642)",
        "pathway": " (hsa:4953);  (R-HSA-350562);  (R-HSA-351202)",
        "pathway_count": 3,
        "publication_count": 125,
        "publication_id_list": "10462479;10623504;10807784;11237011;11461922;11583147;12359729;12660156;15116427;15118850;15749015;1598217;16548883;17407445;17585781;17900240;18367445;1872802;2026163;2069720;2227439;22424782;22544926;22898188;2317811;2318872;23481700;24366607;24386364;24397554;24714562;24715725;25505266;25576301;25645385;2587220;25880248;26154972;26305948;26375851;26443277;26768311;26811146;2693021;26992070;27397612;27600516;27846572;27862975;28228285;28832583;28860189;28904123;29242379;29331515;29493099;29508533;29557506;29632711;29786170;30239107;30315122;30410026;30429286;30475435;30524438;30779550;31092671;31154438;31217245;31222486;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;3308908;33123756;33141586;33298915;33392160;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34405274;34509645;34796899;34932366;35051231;35318648;35561310;35580925;35735188;3595418;36010968;36215666;36241641;36284347;37938771;38473716;38648079;38743820;7506728;7546290;7811704;8486633;8519686",
        "class_list": "",
        "function": "Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis., [UniProtKB, PubMed]; Effects of Spermine Synthase Deficiency in Mesenchymal Stromal Cells Are Rescued by Upstream Inhibition of Ornithine Decarboxylase. Publication Status: Online-Only, [RefSeq, PubMed]; Evaluation of the Influence of Biosurface Design on the Interaction between the Regulatory Peptide RS1-reg and ODC1 Reveals a Membrane-Dependent Affinity Increase., [RefSeq, PubMed]; FOXA1 co-activates circODC1 and ODC1 in HPV-positive cervical cancer cell growth., [RefSeq, PubMed]; Pirin Promotes the Progression of Non-Small-Cell Lung Cancer by Increasing ODC1 to Suppress Autophagy., [RefSeq, PubMed]; Structural basis of binding and inhibition of ornithine decarboxylase by 1-amino-oxy-3-aminopropane., [RefSeq, PubMed]; This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "diagnostic",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53TU3;Q6LDS9",
        "ec_number_list": "3.4.19.12;4.1.1.17;1.6.5.2;3.4.25.1",
        "go_molecular_function": "GO:0004586 ornithine decarboxylase activity;GO:0042803 protein homodimerization activity;GO:0042978 ornithine decarboxylase activator activity;GO:0003824 catalytic activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0009615 response to virus;GO:0006597 spermine biosynthetic process;GO:0008295 spermidine biosynthetic process;GO:0033387 putrescine biosynthetic process from arginine, via ornithine;GO:0042176 regulation of protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 12.6,
        "record_id": "P11926-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P35663-1",
        "uniprot_id": "CYLC1_HUMAN",
        "mass": 74242.0,
        "length": 651,
        "protein_name": "Cylicin-1",
        "gene_name": "CYLC1",
        "organism": "Human",
        "refseq_name": "cylicin-1 isoform 1",
        "refseq_ac": "NP_066941",
        "gene_names_uniprotkb": "CYLC1; CYL1; CYL",
        "gene_names_refseq": "CYCL1; CYLC1; SPGFX8",
        "protein_names_uniprotkb": "Cylicin-1; Cylicin I; Multiple-band polypeptide I",
        "protein_names_refseq": "cylicin I; cylicin, basic protein of sperm head cytoskeleton 1; cylicin-1 isoform 1; multiple-band polypeptide I",
        "tax_id": 9606,
        "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); X-linked spermatogenic failure 8 (Disease Ontology:DOID:0070599); ovarian dysgenesis 8 (Disease Ontology:DOID:0080500); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); hypospadias (Disease Ontology:DOID:10892); urinary bladder cancer (Disease Ontology:DOID:11054); osteoporosis (Disease Ontology:DOID:11476); male infertility (Disease Ontology:DOID:12336); Graves' disease (Disease Ontology:DOID:12361); Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); cystitis (Disease Ontology:DOID:1679); aortic valve stenosis (Disease Ontology:DOID:1712); melanoma (Disease Ontology:DOID:1909); anxiety disorder (Disease Ontology:DOID:2030); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); coronary artery disease (Disease Ontology:DOID:3393); myasthenia gravis (Disease Ontology:DOID:437); pulmonary hypertension (Disease Ontology:DOID:6432); adenoma (Disease Ontology:DOID:657); rheumatoid arthritis (Disease Ontology:DOID:7148); peritonitis (Disease Ontology:DOID:8283); osteoarthritis (Disease Ontology:DOID:8398); ulcerative colitis (Disease Ontology:DOID:8577); prostate carcinoma in situ (Disease Ontology:DOID:8634); in situ carcinoma (Disease Ontology:DOID:8719); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256); alopecia (Disease Ontology:DOID:987); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:1538)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "11237011;19679225;23481700;26992070;29557506;30379171;32488085;35051231;37217939;38013430;38573307;8354692",
        "class_list": "",
        "function": "Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Plays a role in the establishment of normal sperm morphology during spermatogenesis and is required for acrosome attachment to the nuclear envelope., [UniProtKB, PubMed]; This gene encodes a sperm head cytoskeletal protein. The encoded protein is associated with the calyx of spermatozoa and spermatids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 37,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 41,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AVQ8;Q5JQQ9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005198 structural molecule activity",
        "go_cellular_component": "GO:0061827 sperm head;GO:0005634 nucleus;GO:0043159 acrosomal matrix;GO:0033150 cytoskeletal calyx;GO:0033011 perinuclear theca",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0001675 acrosome assembly;GO:0030154 cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "P35663-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96EH3-1",
        "uniprot_id": "MASU1_HUMAN",
        "mass": 26170.0,
        "length": 234,
        "protein_name": "Mitochondrial assembly of ribosomal large subunit protein 1",
        "gene_name": "MALSU1",
        "organism": "Human",
        "refseq_name": "mitochondrial assembly of ribosomal large subunit protein 1",
        "refseq_ac": "NP_612455",
        "gene_names_uniprotkb": "MALSU1; C7orf30",
        "gene_names_refseq": "C7orf30; MALSU1; mtRsfA",
        "protein_names_uniprotkb": "Mitochondrial assembly of ribosomal large subunit protein 1",
        "protein_names_refseq": "mitochondrial assembly of ribosomal large subunit protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:115416);  (R-HSA-9937383)",
        "pathway_count": 2,
        "publication_count": 41,
        "publication_id_list": "16548050;20186120;22238375;22238376;22829778;23171548;25418920;26154972;26811146;26929215;26992070;27029019;27846572;27920218;28063628;28218747;28228285;28649982;28832583;28892042;28904123;29393594;29557506;29632046;29789417;30215512;30315122;31666358;31844290;32265295;32387766;32938616;32983136;33243891;33298915;33878294;33912179;33968037;35051231;35177605;36241641",
        "class_list": "",
        "function": "C7orf30 is a novel human gene indispensable for mitochondrial translation, most probably via its contribution to the biogenesis of the large subunit of the mitochondrial ribosome. Erratum:[Nucleic Acids Res. 2016 Jan 29;44(2):992. doi: 10.1093/nar/gkv1125. PMID: 26487634], [RefSeq, PubMed]; C7orf30 is proposed to be involved in ribosomal large subunit function., [RefSeq, PubMed]; Required for normal mitochondrial ribosome function and mitochondrial translation (PubMed:22238375, PubMed:23171548). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits (Probable). Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes (Probable). May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome (PubMed:22238376, PubMed:23171548). May function as a ribosomal silencing factor (Probable)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D154",
        "ec_number_list": "",
        "go_molecular_function": "GO:0043023 ribosomal large subunit binding;GO:0140978 mitochondrial large ribosomal subunit binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0017148 negative regulation of translation;GO:1902775 mitochondrial large ribosomal subunit assembly;GO:0070130 negative regulation of mitochondrial translation;GO:0090071 negative regulation of ribosome biogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "Q96EH3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N0V3-1",
        "uniprot_id": "RBFA_HUMAN",
        "mass": 38359.0,
        "length": 343,
        "protein_name": "Putative ribosome-binding factor A, mitochondrial",
        "gene_name": "RBFA",
        "organism": "Human",
        "refseq_name": "putative ribosome-binding factor A, mitochondrial isoform 2 precursor",
        "refseq_ac": "NP_001165438",
        "gene_names_uniprotkb": "RBFA; C18orf22",
        "gene_names_refseq": "C18orf22; HsT169; RBFA",
        "protein_names_uniprotkb": "Putative ribosome-binding factor A, mitochondrial",
        "protein_names_refseq": "putative ribosome-binding factor A, mitochondrial isoform 2 precursor; putative ribosome-binding factor A, mitochondrial; ribosome binding factor A (putative)",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79863)",
        "pathway_count": 1,
        "publication_count": 27,
        "publication_id_list": "25576301;25645385;26992070;27600516;27846572;27920218;28834231;28904123;29242379;29632046;29632711;30429286;30779550;31844290;31848261;32387766;32938616;33141586;33298915;33717175;33981976;34357683;34932366;35051231;35580925;35666428;36620886",
        "class_list": "",
        "function": "(1)H, (13)C, and (15)N resonance assignments and solution structures of the KH domain of human ribosome binding factor A, mtRbfA, involved in mitochondrial ribosome biogenesis., [RefSeq, PubMed]; The recognition mode between hsRBFA and mitoribosome 12S rRNA during mitoribosomal biogenesis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6PF07;Q8WZ65;Q9H776",
        "ec_number_list": "",
        "go_molecular_function": "GO:0043024 ribosomal small subunit binding;GO:0019843 rRNA binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0006364 rRNA processing;GO:0180026 mitochondrial small ribosomal subunit assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q8N0V3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P01909-1",
        "uniprot_id": "DQA1_HUMAN",
        "mass": 27805.0,
        "length": 254,
        "protein_name": "HLA class II histocompatibility antigen, DQ alpha 1 chain",
        "gene_name": "HLA-DQA1",
        "organism": "Human",
        "refseq_name": "HLA class II histocompatibility antigen, DQ alpha 1 chain precursor",
        "refseq_ac": "NP_002113",
        "gene_names_uniprotkb": "HLA-DQA1",
        "gene_names_refseq": "CELIAC1; DQ-A1; DQA1; HLA-DQA1*; HLA-DQA1; HLA-DQA",
        "protein_names_uniprotkb": "HLA class II histocompatibility antigen, DQ alpha 1 chain; DC-1 alpha chain; DC-alpha; HLA-DCA; MHC class II DQA1",
        "protein_names_refseq": "DC-1 alpha chain; DC-alpha; HLA class II histocompatibility antigen DQ alpha chain; HLA class II histocompatibility antigen, DQ alpha 1 chain precursor; HLA class II histocompatibility antigen, DQ alpha 1 chain; MHC HLA-DQ alpha; MHC class II DQ alpha chain; MHC class II DQA1; MHC class II HLA-DQ-alpha-1; MHC class II antigen DQA1; MHC class II protein",
        "tax_id": 9606,
        "disease": "autoimmune polyendocrine syndrome type 2 (Disease Ontology:DOID:0050168); marginal zone lymphoma (Disease Ontology:DOID:0050748); rheumatic heart disease (Disease Ontology:DOID:0050827); extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (Disease Ontology:DOID:0050909); stroke (Disease Ontology:DOID:0051061); paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); lupus nephritis (Disease Ontology:DOID:0080162); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); stomach cancer (Disease Ontology:DOID:10534); glucose intolerance (Disease Ontology:DOID:10603); celiac disease (Disease Ontology:DOID:10608); hypertension (Disease Ontology:DOID:10763); lepromatous leprosy (Disease Ontology:DOID:10887); membranous glomerulonephritis (Disease Ontology:DOID:10976); IgA vasculitis (Disease Ontology:DOID:11123); rhinoscleroma (Disease Ontology:DOID:11336); onchocerciasis (Disease Ontology:DOID:11678); allergic disease (Disease Ontology:DOID:1205); factor VIII deficiency (Disease Ontology:DOID:12134); primary biliary cholangitis (Disease Ontology:DOID:12236); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); aplastic anemia (Disease Ontology:DOID:12449); choreatic disease (Disease Ontology:DOID:12859); Sjogren's syndrome (Disease Ontology:DOID:12894); uveitis (Disease Ontology:DOID:13141); congenital toxoplasmosis (Disease Ontology:DOID:13336); autoimmune polyendocrine syndrome (Disease Ontology:DOID:14040); colon carcinoma (Disease Ontology:DOID:1520); diffuse scleroderma (Disease Ontology:DOID:1580); rheumatic fever (Disease Ontology:DOID:1586); breast cancer (Disease Ontology:DOID:1612); hepatitis C (Disease Ontology:DOID:1883); melanoma (Disease Ontology:DOID:1909); hepatitis B (Disease Ontology:DOID:2043); multiple sclerosis (Disease Ontology:DOID:2377); thrombophilia (Disease Ontology:DOID:2452); asthma (Disease Ontology:DOID:2841); antiphospholipid syndrome (Disease Ontology:DOID:2988); brain infarction (Disease Ontology:DOID:3454); gastric adenocarcinoma (Disease Ontology:DOID:3717); autoimmune disease (Disease Ontology:DOID:417); systemic scleroderma (Disease Ontology:DOID:418); myasthenia gravis (Disease Ontology:DOID:437); rhinitis (Disease Ontology:DOID:4483); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myositis (Disease Ontology:DOID:633); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); autoimmune thyroiditis (Disease Ontology:DOID:7188); abdominal aortic aneurysm (Disease Ontology:DOID:7693); arthritis (Disease Ontology:DOID:848); chronic fatigue syndrome (Disease Ontology:DOID:8544); chronic myeloid leukemia (Disease Ontology:DOID:8552); psoriasis (Disease Ontology:DOID:8893); visceral leishmaniasis (Disease Ontology:DOID:9146); achalasia (Disease Ontology:DOID:9164); pemphigus (Disease Ontology:DOID:9182); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)",
        "pathway": " (hsa:3117);  (R-HSA-202424);  (R-HSA-202427);  (R-HSA-202430);  (R-HSA-202433);  (R-HSA-2132295);  (R-HSA-389948);  (R-HSA-877300)",
        "pathway_count": 8,
        "publication_count": 269,
        "publication_id_list": "10036229;10064083;10067896;10072072;10395113;10480952;10540230;10593899;10631941;10631952;10639150;10671560;10698680;10716940;10747096;10748235;10790433;10809954;10811803;10986460;11048639;11237011;11358993;11376336;11390650;11529500;11607830;11684289;11752630;11790530;11813165;11827988;11853874;11884229;11972023;12040185;12078484;12198549;12438563;12446674;12473184;12485116;12660731;12742663;12748383;12893276;12915721;12938237;12947224;1362295;1396683;14510693;14514672;14586410;14722222;14731593;14769912;15020763;15084594;1508672;15122200;15125833;15143187;15145317;15322115;15358536;15371334;15388922;15489910;15489916;15530433;15541657;15749704;15853899;15911768;16056267;16140993;16181339;16237089;16242130;16356853;16356855;16364187;16461343;16467876;16612002;16618111;16824007;16866887;16978534;17047224;17072321;17125875;17135271;17142755;17241953;17283181;17363905;17468049;17496917;17548359;17629515;17652306;17728323;18046453;18173375;18292509;18362138;18591661;18759926;19092054;19533806;1956401;19564404;20049711;20130243;20304997;20346773;20363976;21116285;21154117;2121367;21441454;21543337;21654843;2190094;22426112;23061660;23302904;23481700;23580664;23719902;2391366;24190977;24366607;24417533;24714562;2493052;2513578;2530588;25502872;25505266;25645385;25880248;25892735;26154972;26375851;26811146;27846572;27920218;28165004;28218747;28265006;28832583;2888727;28904123;29242379;29393594;29557506;29632046;29632711;29741879;29786170;29863979;30315122;3036828;30429286;30522017;31020640;3129499;31313098;31844290;32157095;32350084;32357974;32387766;32502341;3259543;32897882;32983136;33091337;33239784;33298915;33592498;33633747;33717175;3372263;33912179;33936100;34357683;34433824;34509645;34932366;35051231;35154160;35580925;3584986;36581221;37074911;37460671;37958966;38012279;38182727;3879967;39041300;6415485;6576979;6584734;6585297;6815651;7479848;7481823;7510216;7514165;7530745;7565724;7592972;7615558;7617032;7650016;7657660;7667286;7673114;7690989;7796299;8046351;8134367;8145819;8148318;8156998;8176225;8313912;8397411;8415765;8483949;8520027;8530158;8550590;8550631;8598037;8601309;8631301;8642258;8687433;8798379;8824201;8849454;8909537;8929711;8939989;8947036;9075930;9111318;9115214;9143706;9202021;9252186;9271631;9311912;9312039;9362451;9497313;9539769;9545226;9606180;9687533;9846482;9850860;9990853",
        "class_list": "",
        "function": "A web-based genome-wide association study reveals the susceptibility loci of common adverse events following COVID-19 vaccination in the Japanese population. Publication Status: Online-Only, [RefSeq, PubMed]; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading., [UniProtKB]; Candidate Genes for IgA Nephropathy in Pediatric Patients: Exome-Wide Association Study. Publication Status: Online-Only, [RefSeq, PubMed]; HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]., [RefSeq]; HLA-DQA1*01:03 and DQB1*06:01 are risk factors for severe COVID-19 pneumonia., [RefSeq, PubMed]; HLA-DQA1*05 and upstream variants of PPARGC1B are associated with infliximab persistence in Japanese Crohn's disease patients., [RefSeq, PubMed]; Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 9015,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 67,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O19630;O19706;P01907;P01908;P04225;P04226;P05536;P79553;Q06751;Q29876;Q29994;Q2Q6Y6;Q2Q6Y7;Q2Q6Y8;Q2WCM3;Q30064;Q30067;Q30068;Q30070;Q30071;Q30072;Q30073;Q30086;Q30101;Q5Y7D5;Q5Y7F5;Q6ICU6;Q6PR46;Q6QDB1;Q860W2;Q860W4;Q9BD37;Q9TPM3;Q9UM31",
        "ec_number_list": "",
        "go_molecular_function": "GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding;GO:0032395 MHC class II receptor activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032588 trans-Golgi network membrane;GO:0005765 lysosomal membrane",
        "go_biological_process": "GO:0006955 immune response;GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0002250 adaptive immune response;GO:0050870 positive regulation of T cell activation",
        "synthesized_glycan_count": 0,
        "hit_score": 28.2,
        "record_id": "P01909-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NZJ0-1",
        "uniprot_id": "DTL_HUMAN",
        "mass": 79468.0,
        "length": 730,
        "protein_name": "Denticleless protein homolog",
        "gene_name": "DTL",
        "organism": "Human",
        "refseq_name": "denticleless protein homolog isoform 1",
        "refseq_ac": "NP_057532",
        "gene_names_uniprotkb": "DTL; CDT2; CDW1; DCAF2; L2DTL; RAMP",
        "gene_names_refseq": "CDT2; DCAF2; DTL; L2DTL; RAMP",
        "protein_names_uniprotkb": "Denticleless protein homolog; DDB1- and CUL4-associated factor 2; Lethal(2) denticleless protein homolog; Retinoic acid-regulated nuclear matrix-associated protein",
        "protein_names_refseq": "DDB1- and CUL4-associated factor 2; RA-regulated nuclear matrix-associated protein; denticleless E3 ubiquitin protein ligase homolog; denticleless protein homolog isoform 1; denticleless protein homolog; lethal(2) denticleless protein homolog; retinoic acid-regulated nuclear matrix-associated protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51514);  (R-HSA-110314);  (R-HSA-8951664)",
        "pathway_count": 3,
        "publication_count": 201,
        "publication_id_list": "10.1101/2023.09.13.557529;10535940;10597293;10811609;10878807;10973499;11069780;11237011;11259415;11278750;11292861;11292862;11454738;11585840;11733065;11961546;12101228;12186903;12226657;12504025;12504026;12526791;12538644;12609982;12682069;12759363;12816948;14690597;14757770;15282312;15361859;15367669;15537541;15572695;15574592;15601839;15652483;15688063;15694336;15799966;15916957;16171779;16401342;16531995;16547496;16647857;16707496;16790436;16861890;16861906;16943200;16949367;16964240;17041588;17081101;17085480;17106265;17132228;17183367;17220875;17332328;17497243;17720710;17785452;18093314;18206966;18342608;18669648;18703516;18775313;18776931;18794347;18794348;18805092;18826954;18851830;18926707;19250909;19321346;19332548;19617556;19690332;19748355;20068231;20129063;21406692;21447816;21463634;21778237;21863050;21940857;22223895;22306028;22466964;22537386;22959436;23000965;23186163;23201271;23213251;23333871;23401859;23453757;23478441;23478445;23481700;23535662;23535663;23563313;23583660;23677613;23892434;23912815;23986495;24076655;24366543;24636985;24714562;24715725;24768535;24793695;24793696;25314029;25349211;25355947;25531226;25576301;26154972;26344709;26375851;26431207;26460955;26632597;26728094;26811146;26906416;26992070;27030794;27222660;27565346;27600516;27846572;27906959;27920218;28115426;28218747;28228285;28411811;28514659;28832583;28834231;28904123;29153394;29242379;29393594;29437277;29493099;29508533;29557506;29632046;30315122;30410026;30524438;30610225;31217245;31844290;32005965;32157095;32284348;32357974;32387766;32488085;32502341;32897882;33141586;33298915;33392160;33444648;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34509645;35051231;35561310;36010968;36215666;36284347;37171007;37522575;37968553;37968554;38253038;9790970;9887101;9891082",
        "class_list": "",
        "function": "Circ-DTL sponges miR-758-3p to accelerate cervical cancer malignant progression by regulating DCUN1D1 expression., [RefSeq, PubMed]; DTL is a Novel Downstream Gene of E2F1 that Promotes the Progression of Hepatocellular Carcinoma., [RefSeq, PubMed]; Epithelial CRL4[DCAF2] Is Critical for Maintaining Intestinal Homeostasis Against DSS-Induced Colitis by Regulating the Proliferation and Repair of Intestinal Epithelial Cells., [RefSeq, PubMed]; L2DTL and PCNA interact with CUL4/DDB1 complexes and are involved in CDT1 degradation after DNA damage., [RefSeq, PubMed]; PCNA, L2DTL and the DDB1-CUL4A complex play critical and differential roles in regulating the protein stability of p53 and MDM2/HDM2 in unstressed and stressed cells., [RefSeq, PubMed]; Regular or DCAF2: How CRL4[DCAF2] Affects IBD-Related Mucosal Injury., [RefSeq, PubMed]; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; These studies uncover diverse substrate receptors for Cul4 and identify Cdt2 as a conserved component of the Cul4-Ddb1 E3 that is essential to destroy Cdt1 and ensure proper cell cycle regulation of DNA replication., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 15,
        "reported_mutagensis": 16,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K8H8;D3DT98;Q5VT77;Q96SN0;Q9NW03;Q9NW34;Q9NWM5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity",
        "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0031965 nuclear membrane",
        "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0009411 response to UV",
        "synthesized_glycan_count": 0,
        "hit_score": 20.6,
        "record_id": "Q9NZJ0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A4FU69-1",
        "uniprot_id": "EFCB5_HUMAN",
        "mass": 173404.0,
        "length": 1503,
        "protein_name": "EF-hand calcium-binding domain-containing protein 5",
        "gene_name": "EFCAB5",
        "organism": "Human",
        "refseq_name": "EF-hand calcium-binding domain-containing protein 5 isoform b",
        "refseq_ac": "NP_001138525",
        "gene_names_uniprotkb": "EFCAB5",
        "gene_names_refseq": "EFCAB5",
        "protein_names_uniprotkb": "EF-hand calcium-binding domain-containing protein 5",
        "protein_names_refseq": "EF-hand calcium-binding domain-containing protein 5 isoform b; EF-hand calcium-binding domain-containing protein 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:374786)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11237011;18669648;21509594;24715725;25576301;28467828;30379171;32488085;33592498;34087483;34509645;35051231;35494241",
        "class_list": "",
        "function": "EFCAB5 gene expression is decreased in papillary thyroid carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RPN0;B4DS75;B4DZR5;F5GYL2;Q0VD68;Q6ZRM6;Q8NDG9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "A4FU69-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14574-1",
        "uniprot_id": "DSC3_HUMAN",
        "mass": 99969.0,
        "length": 896,
        "protein_name": "Desmocollin-3",
        "gene_name": "DSC3",
        "organism": "Human",
        "refseq_name": "desmocollin-3 isoform Dsc3a preproprotein",
        "refseq_ac": "NP_001932",
        "gene_names_uniprotkb": "DSC3; CDHF3; DSC4",
        "gene_names_refseq": "CDHF3; DSC1; DSC2; DSC3; DSC4; DSC; HT-CP",
        "protein_names_uniprotkb": "Desmocollin-3; Cadherin family member 3; Desmocollin-4; HT-CP",
        "protein_names_refseq": "cadherin family member 3; desmocollin-3 isoform Dsc3a preproprotein; desmocollin-4",
        "tax_id": 9606,
        "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); metachromatic leukodystrophy (Disease Ontology:DOID:10581); hereditary hypotrichosis with recurrent skin vesicles (MONDO:MONDO:0013136)",
        "pathway": " (hsa:1825);  (R-HSA-6805567);  (R-HSA-6809371)",
        "pathway_count": 3,
        "publication_count": 86,
        "publication_id_list": "10.1101/2023.09.13.557529;10066784;10196183;10231017;10411887;10588656;10771479;11027496;11237011;11350120;11380615;11590230;12902340;15033990;15337775;15373777;15797384;15803139;16061697;16382671;16639001;1691188;1694855;1714783;17322306;17515931;17521629;17562024;17596512;18292551;18843291;19190773;19194479;19717567;19765682;20068231;20179351;20657595;20667819;20940292;21439340;21654840;21654843;21997417;23090970;23481192;23629652;2414304;24190977;24715725;25208914;25502872;25926655;26374642;26375851;26390218;26992070;27920218;28467828;28514659;28855257;29242379;29314611;29393594;29508533;30857973;31092671;31154438;31844290;32350084;32983136;33766509;34171305;35051231;35154160;36305887;38651843;38665916;7543090;7665906;7929347;8824274;8999895;9395522;9468612;9565599",
        "class_list": "",
        "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function (PubMed:19717567). Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage (By similarity). Essential for successful completion of embryo compaction and embryo development (By similarity)., [UniProtKB, PubMed, UniProtKB]; Autoantibodies to DSC3 in Pemphigus Exclusively Recognize Calcium-Dependent Epitope in Extracellular Domain 2., [RefSeq, PubMed]; DSC3 suppresses colorectal cancer cell growth through inhibition of AKT pathway and regulation of E-cadherin, [RefSeq, PubMed]; The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]., [RefSeq]; Two cases of Hallopeau-type pemphigus vegetans with anti-desmoglein 1 and anti-desmocollin 3 antibodies without mucosal involvement., [RefSeq, PubMed]; Upregulation of Anti-Desmocollin 3 Antibodies in Pemphigus Diseases: A Case-control Study., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 40,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 3,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NN35;Q14200;Q9HAZ9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045295 gamma-catenin binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0098609 cell-cell adhesion;GO:0050821 protein stabilization;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules",
        "synthesized_glycan_count": 0,
        "hit_score": 9.4,
        "record_id": "Q14574-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0CV98-1",
        "uniprot_id": "TSPY3_HUMAN",
        "mass": 35101.0,
        "length": 308,
        "protein_name": "Testis-specific Y-encoded protein 3",
        "gene_name": "TSPY10; TSPY3; TSPY4",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "TSPY10; TSPY3; TSPY4; TSPY3; TSPY4",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Testis-specific Y-encoded protein 3",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100289087);  (hsa:728137)",
        "pathway_count": 2,
        "publication_count": 1,
        "publication_id_list": "11237011",
        "class_list": "",
        "function": "May be involved in sperm differentiation and proliferation., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006334 nucleosome assembly;GO:0007506 gonadal mesoderm development",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "P0CV98-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P51808-1",
        "uniprot_id": "DYLT3_HUMAN",
        "mass": 13062.0,
        "length": 116,
        "protein_name": "Dynein light chain Tctex-type 3",
        "gene_name": "DYNLT3",
        "organism": "Human",
        "refseq_name": "dynein light chain Tctex-type 3",
        "refseq_ac": "NP_006511",
        "gene_names_uniprotkb": "DYNLT3; TCTE1L; TCTE1XL",
        "gene_names_refseq": "DYNLT3; RP3; TCTE1L; TCTEX1L",
        "protein_names_uniprotkb": "Dynein light chain Tctex-type 3; Protein 91/23; T-complex-associated testis-expressed 1-like",
        "protein_names_refseq": "dynein light chain Tctex-type 3; protein 91/23",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6990)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11237011;16079286;17289665;28510447;28832583;29242379;31154438;31844290;32488085;33912179;35580925;37260179;8004092",
        "class_list": "",
        "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The role of DYNLT3 in breast cancer proliferation, migration, and invasion via epithelial-to-mesenchymal transition., [RefSeq, PubMed]; This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ICS3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0045505 dynein intermediate chain binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium;GO:0001673 male germ cell nucleus;GO:0000776 kinetochore;GO:0005868 cytoplasmic dynein complex",
        "go_biological_process": "GO:0045931 positive regulation of mitotic cell cycle;GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle;GO:0007018 microtubule-based movement;GO:0032388 positive regulation of intracellular transport",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "P51808-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NEJ0-1",
        "uniprot_id": "DUS18_HUMAN",
        "mass": 21066.0,
        "length": 188,
        "protein_name": "Dual specificity protein phosphatase 18",
        "gene_name": "DUSP18",
        "organism": "Human",
        "refseq_name": "dual specificity protein phosphatase 18 isoform a",
        "refseq_ac": "NP_001291723",
        "gene_names_uniprotkb": "DUSP18; LMWDSP20",
        "gene_names_refseq": "DSP18; DUSP18; DUSP20; LMWDSP20",
        "protein_names_uniprotkb": "Dual specificity protein phosphatase 18; 3.1.3.16; 3.1.3.48; LMW-DSP20; Low molecular weight dual specificity phosphatase 20",
        "protein_names_refseq": "dual specificity protein phosphatase 18 isoform a; dual specificity protein phosphatase 18; low molecular weight dual specificity phosphatase 20",
        "tax_id": 9606,
        "disease": "chromosome 17q12 deletion syndrome (Disease Ontology:DOID:0060404)",
        "pathway": " (hsa:150290)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11237011;12408986;12591617;16699184;16720344;18477386;28218747;29437277;29852174;31844290;35841693;37217939;38346942",
        "class_list": "",
        "function": "Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). In bone tissue, upon activation of the G(q)-dependent KISS1/KISS1R signaling pathway, DUSP18 is recruited to the KISS1R C-terminus where it dephosphorylates SRC, resulting in down-regulation of osteoclast differentiation and activity, and consequently suppression of bone resorption (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; DUSP18 appears to serve an important role by regulation of SAPK/JNK pathway Publication Status: Online-Only, [RefSeq, PubMed]; Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]., [RefSeq]; Hypoxia-induced HIF1A activates DUSP18-mediated MAPK14 dephosphorylation to promote hepatocellular carcinoma cell migration and invasion., [RefSeq, PubMed]; JNK and DUSP18 reciprocally modulate the SUMOylation, which plays a regulatory role in the aggregation of ataxin-1., [RefSeq, PubMed]; Molecular cloning, base sequence and amino acid sequence, [RefSeq, PubMed]; The crystal structure of human DSP18 (official symbol DUSP18) has been determined at 2.0 A resolution., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KPA4",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.21;3.1.3.18;3.1.3.-;3.1.3.5;3.1.3.2;2.7.10.1;3.1.3.67;3.1.3.53;3.1.3.52;3.1.3.27;3.1.3.86;3.1.3.36;3.1.3.74",
        "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0016791 phosphatase activity;GO:0004725 protein tyrosine phosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane",
        "go_biological_process": "GO:0016311 dephosphorylation;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0045671 negative regulation of osteoclast differentiation;GO:0045779 negative regulation of bone resorption;GO:0035970 peptidyl-threonine dephosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q8NEJ0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WW22-1",
        "uniprot_id": "DNJA4_HUMAN",
        "mass": 44798.0,
        "length": 397,
        "protein_name": "DnaJ homolog subfamily A member 4",
        "gene_name": "DNAJA4",
        "organism": "Human",
        "refseq_name": "dnaJ homolog subfamily A member 4 isoform 2",
        "refseq_ac": "NP_001123654",
        "gene_names_uniprotkb": "DNAJA4",
        "gene_names_refseq": "DNAJA4; MST104; MSTP104; PRO1472",
        "protein_names_uniprotkb": "DnaJ homolog subfamily A member 4",
        "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily A, member 4; dnaJ homolog subfamily A member 4 isoform 2; dnaJ homolog subfamily A member 4",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)",
        "pathway": " (hsa:55466);  (R-HSA-3371497)",
        "pathway_count": 2,
        "publication_count": 86,
        "publication_id_list": "10747884;11237011;11589254;11701661;11751894;12781197;13486053;1493716;15159550;15381148;15591061;16403413;17591767;17804755;18215318;18243712;18254226;18635947;19359544;20006655;20038533;20072699;21158691;21183720;21376746;21700222;21796517;22011577;22266222;22318716;22433123;22791416;23186163;24012426;24694367;25576301;25645385;26073023;26203193;26313416;27462449;27663436;28083797;28301631;28755533;28919297;29242379;29493099;29557506;29632046;29807809;30197098;30429286;31110491;31141847;31154438;31731497;31826031;32016915;32157095;32320027;32350084;32387766;32448030;32488085;32544881;32938616;32982970;32983136;33968037;33981976;34509645;34932366;35051231;35580925;36420716;36672799;37875476;6645495;6891012;8157723;8282004;8560673;9464360;9464361;9667968",
        "class_list": "",
        "function": "DNA methylation status of DNAJA4 is essential for human erythropoiesis., [RefSeq, PubMed]; DNAJA4 Promotes the Replication of the Chinese Giant Salamander Iridovirus. Publication Status: Online-Only, [RefSeq, PubMed]; DNAJA4 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation. Publication Status: Online-Only, [RefSeq, PubMed]; Hyperthermia reduced HaCaT cell proliferation and promoted cytokine expressions responsible for anti-viral activity, mainly through a NF-kB dependent pathway. DNAJA4-deficiency enhanced the activation of NF-kB by hyperthermia in HaCaT cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PDM9;Q6AW87;Q8N5Z4;Q8N7P2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0001671 ATPase activator activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0090084 negative regulation of inclusion body assembly;GO:0010628 positive regulation of gene expression;GO:0034605 cellular response to heat;GO:0010596 negative regulation of endothelial cell migration;GO:0042026 protein refolding",
        "synthesized_glycan_count": 0,
        "hit_score": 8.7,
        "record_id": "Q8WW22-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UNA4-1",
        "uniprot_id": "POLI_HUMAN",
        "mass": 83006.0,
        "length": 740,
        "protein_name": "DNA polymerase iota",
        "gene_name": "POLI",
        "organism": "Human",
        "refseq_name": "DNA polymerase iota isoform a (long)",
        "refseq_ac": "NP_009126",
        "gene_names_uniprotkb": "POLI; RAD30B",
        "gene_names_refseq": "POLI; RAD30B; RAD3OB; eta2",
        "protein_names_uniprotkb": "DNA polymerase iota; 2.7.7.7; Eta2; RAD30 homolog B",
        "protein_names_refseq": "DNA polymerase iota isoform a (long); RAD30 homolog B; polymerase (DNA directed) iota; polymerase (DNA) iota; polymerase (DNA-directed), iota",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11201);  (R-HSA-5656121);  (R-HSA-5656169)",
        "pathway_count": 3,
        "publication_count": 59,
        "publication_id_list": "10458907;10801132;10856253;10984059;11006276;11013228;11230166;11237011;11251121;11387224;12410315;12444249;12584190;12606586;14630940;14657033;15189446;15199127;15254543;15657443;16357261;16819516;17043239;17322306;18242152;19153606;20159559;20388628;21143968;21628590;22700975;22859295;23000965;23143872;23593430;24449906;24768535;26370087;27555320;28832583;29485866;30429286;31217245;31844290;32157095;32387766;32938616;33087280;33166398;33298915;33376220;33912179;33968037;34165573;34509645;34645785;35051231;8658138;8751446",
        "class_list": "",
        "function": "DNA polymerase iota compensates for Fanconi anemia pathway deficiency by countering DNA replication stress., [RefSeq, PubMed]; Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11013228, PubMed:11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11013228, PubMed:11387224, PubMed:14630940, PubMed:15199127, PubMed:20388628). Favors Hoogsteen base-pairing in the active site (PubMed:15254543). Inserts the correct base with high-fidelity opposite an adenosine template (PubMed:15254543). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed:11013228). May play a role in hypermutation of immunoglobulin genes (PubMed:12410315). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (PubMed:11251121, PubMed:14630940)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices., [RefSeq, PubMed]; Mass spectrometry analysis of monoubiquitinated poliota revealed that it is ubiquitinated at over 27 unique sites. Many of these sites are localized in different functional domains of the protein., [RefSeq, PubMed]; Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance., [RefSeq, PubMed]; Mysterious and fascinating: DNA polymerase i remains enigmatic 20 years after its discovery. Review article, [RefSeq, PubMed]; P53 isoforms differentially impact on the POLiota dependent DNA damage tolerance pathway. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is an error-prone DNA polymerase involved in DNA repair. The encoded protein promotes DNA synthesis across lesions in the template DNA, which other polymerases cannot do. The encoded polymerase inserts deoxynucleotides across lesions and then relies on DNA polymerase zeta to extend the nascent DNA strand to bypass the lesion. [provided by RefSeq, May 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N590;Q9H0S1;Q9NYH6",
        "ec_number_list": "2.7.7.49;3.1.21.-;2.3.2.23;2.7.7.7;5.6.2.4;2.7.7.31;4.2.99.18;4.2.99.-;3.1.26.4;3.4.23.50;3.1.11.-;6.2.1.-;2.3.2.27;6.3.2.n3;3.4.19.12;2.7.7.102;2.7.7.-",
        "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0046872 metal ion binding;GO:0003684 damaged DNA binding;GO:0016740 transferase activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0006281 DNA repair;GO:0019985 translesion synthesis;GO:0042276 error-prone translesion synthesis;GO:0071897 DNA biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "Q9UNA4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H2R5-1",
        "uniprot_id": "KLK15_HUMAN",
        "mass": 28087.0,
        "length": 256,
        "protein_name": "Kallikrein-15",
        "gene_name": "KLK15",
        "organism": "Human",
        "refseq_name": "kallikrein-15 isoform 6 preproprotein",
        "refseq_ac": "NP_001264011",
        "gene_names_uniprotkb": "KLK15",
        "gene_names_refseq": "ACO; HSRNASPH; KLK15",
        "protein_names_uniprotkb": "Kallikrein-15; 3.4.21.-; ACO protease",
        "protein_names_refseq": "ACO protease; kallikrein-15 isoform 6 preproprotein; kallikrein-like serine protease; prostinogen",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55554)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11010966;11054574;11237011;14759258;16959974;29928903;29958881;32334022;8018728",
        "class_list": "",
        "function": "Data provide insights into the localization and possible role of KLK15 in human physiology., [RefSeq, PubMed]; Identification and characterization of novel KLK15 alternative splice variants and their expression patterns in a wide panel of human cancer and normal cell lines, [RefSeq, PubMed]; KLK15 may be able to cleave many ECM components, similar to several members of the KLK family. Thus the protease could potentially be linked to tumorigenesis by promoting metastasis via this mechanism., [RefSeq, PubMed]; Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]; Protease whose physiological substrate is not yet known., [UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AUY8;Q15358;Q6ISI0;Q9H2R3;Q9H2R4;Q9H2R6;Q9HBG9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0005576 extracellular region",
        "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q9H2R5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14117-1",
        "uniprot_id": "DPYS_HUMAN",
        "mass": 56630.0,
        "length": 519,
        "protein_name": "Dihydropyrimidinase",
        "gene_name": "DPYS",
        "organism": "Human",
        "refseq_name": "dihydropyrimidinase",
        "refseq_ac": "NP_001376",
        "gene_names_uniprotkb": "DPYS",
        "gene_names_refseq": "DHPase; DHP; DPYS",
        "protein_names_uniprotkb": "Dihydropyrimidinase; 3.5.2.2; DHPase; DHP; Dihydropyrimidine amidohydrolase; Hydantoinase",
        "protein_names_refseq": "dihydropyrimidinase; dihydropyrimidine amidohydrolase; hydantoinase",
        "tax_id": 9606,
        "disease": "dihydropyrimidinase deficiency (Disease Ontology:DOID:0111629); purine-pyrimidine metabolic disorder (Disease Ontology:DOID:653)",
        "pathway": " (hsa:1807);  (R-HSA-73621)",
        "pathway_count": 2,
        "publication_count": 41,
        "publication_id_list": "10364222;10681516;10899995;10989446;11083867;11133996;11237011;12124385;12352955;12849978;12947102;14725767;15385443;1590793;16377327;19291308;20018850;2129526;2157703;2344353;24275569;27846572;2826576;29557506;31154438;31844290;31848261;31853544;32161166;32938616;33392160;35051231;35580925;36284347;36414408;37946254;7284378;7488099;8083224;8973361;9718352",
        "class_list": "",
        "function": "Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate., [UniProtKB]; Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]., [RefSeq]; Functional Characterization of 12 Dihydropyrimidinase Allelic Variants in Japanese Individuals for the Prediction of 5-Fluorouracil Treatment-Related Toxicity., [RefSeq, PubMed]; The burden of rare variants in DPYS gene is a novel predictor of the risk of developing severe fluoropyrimidine-related toxicity. Publication Status: Online-Only, [RefSeq, PubMed]; This study defines dihydropyrimidines as potentially cytotoxic metabolites that may offer an opportunity for therapeutic-targeting of dihydropyrimidinase activity in solid tumors., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "3.5.2.2",
        "go_molecular_function": "GO:0004157 dihydropyrimidinase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0051219 phosphoprotein binding;GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds",
        "go_cellular_component": "GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0046079 dUMP catabolic process;GO:0006208 pyrimidine nucleobase catabolic process;GO:0006210 thymine catabolic process;GO:0006212 uracil catabolic process;GO:0006248 CMP catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "Q14117-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6P1R4-1",
        "uniprot_id": "DUS1L_HUMAN",
        "mass": 53230.0,
        "length": 473,
        "protein_name": "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like",
        "gene_name": "DUS1L",
        "organism": "Human",
        "refseq_name": "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like",
        "refseq_ac": "NP_071439",
        "gene_names_uniprotkb": "DUS1L; DUS1",
        "gene_names_refseq": "DUS1L; DUS1; PP3111",
        "protein_names_uniprotkb": "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like; 1.3.1.88; tRNA-dihydrouridine synthase 1-like",
        "protein_names_refseq": "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64118)",
        "pathway_count": 1,
        "publication_count": 34,
        "publication_id_list": "11237011;19413330;23481700;25576301;26992070;28832583;28904123;29242379;29632046;29786170;30524438;31844290;32157095;32357974;32387766;32488085;32502341;32897882;32938616;33141586;33298915;33717175;33968037;33981976;34087483;34171305;34357683;34509645;34798057;35051231;35561310;36010968;36215666;39354220",
        "class_list": "",
        "function": "Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:34798057, PubMed:39354220). Specifically modifies U16 and U17 in cytoplasmic tRNAs (PubMed:39354220). Affects the level of some mature tRNA and thereby the total cellular translation (PubMed:39354220)., [UniProtKB, PubMed, PubMed]; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U16 and U17 in cytoplasmic tRNAs. Affects the level of some mature tRNA and thereby the total cellular translation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Human DUS1L catalyzes dihydrouridine modification at tRNA positions 16/17, and DUS1L overexpression perturbs translation. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NHV4;Q96AI3",
        "ec_number_list": "1.3.1.88",
        "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0017150 tRNA dihydrouridine synthase activity;GO:0102262 tRNA-dihydrouridine16 synthase activity;GO:0102263 tRNA-dihydrouridine17 synthase activity;GO:0016491 oxidoreductase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0002943 tRNA dihydrouridine synthesis;GO:0008033 tRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q6P1R4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P52429-1",
        "uniprot_id": "DGKE_HUMAN",
        "mass": 63927.0,
        "length": 567,
        "protein_name": "Diacylglycerol kinase epsilon",
        "gene_name": "DGKE",
        "organism": "Human",
        "refseq_name": "diacylglycerol kinase epsilon",
        "refseq_ac": "NP_003638",
        "gene_names_uniprotkb": "DGKE; DAGK5",
        "gene_names_refseq": "AHUS7; DAGK5; DAGK6; DGKE; DGK; NPHS7",
        "protein_names_uniprotkb": "Diacylglycerol kinase epsilon; 2.7.1.107; DAG kinase epsilon; DGK-epsilon; Diglyceride kinase epsilon",
        "protein_names_refseq": "DAG kinase epsilon; DGK-epsilon; diacylglycerol kinase epsilon; diacylglycerol kinase, epsilon 64kDa; diglyceride kinase epsilon",
        "tax_id": 9606,
        "disease": "nephrotic syndrome type 7 (Disease Ontology:DOID:0080388)",
        "pathway": " (hsa:8526);  (R-HSA-114508)",
        "pathway_count": 2,
        "publication_count": 45,
        "publication_id_list": "10571048;11080611;11237011;11413485;11805119;15544348;16959974;18004883;19033211;19744926;21477596;2175712;22108654;23274426;23542698;23949095;25880248;25892735;26992070;28904123;29493099;29557506;29769354;30315122;31844290;32157095;32357974;32387766;32413569;32983136;33298915;33912179;33986189;34171305;34509645;34932366;35051231;35580925;36010968;36113832;36241641;38008259;8626589;9601053;9930701",
        "class_list": "",
        "function": "An intact zinc finger motif of the C1B domain is critical for stability and activity of diacylglycerol kinase-epsilon., [RefSeq, PubMed]; Diacylglycerol kinase-epsilon is S-palmitoylated on cysteine in the cytoplasmic end of its N-terminal transmembrane fragment., [RefSeq, PubMed]; Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. [provided by RefSeq, Jul 2008]., [RefSeq]; Loss of diacylglycerol kinase epsilon causes thrombotic microangiopathy by impairing endothelial VEGFA signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle. Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Various phenotypes of disease associated with mutated DGKE gene., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8TBM4;Q9UKQ3",
        "ec_number_list": "2.7.1.107;2.7.1.93;2.7.1.94;2.7.1.138",
        "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016301 kinase activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0046834 lipid phosphorylation;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction;GO:0030168 platelet activation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.6,
        "record_id": "P52429-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q01628-1",
        "uniprot_id": "IFM3_HUMAN",
        "mass": 14632.0,
        "length": 133,
        "protein_name": "Interferon-induced transmembrane protein 3",
        "gene_name": "IFITM3",
        "organism": "Human",
        "refseq_name": "interferon-induced transmembrane protein 3",
        "refseq_ac": "NP_066362",
        "gene_names_uniprotkb": "IFITM3",
        "gene_names_refseq": "1-8U; DSPA2b; IFITM3; IP15",
        "protein_names_uniprotkb": "Interferon-induced transmembrane protein 3; DSPA2b; Dispanin subfamily A member 2b; Interferon-inducible protein 1-8U",
        "protein_names_refseq": "dispanin subfamily A member 2b; interferon-induced transmembrane protein 3; interferon-inducible protein 1-8U",
        "tax_id": 9606,
        "disease": "COVID-19 (Disease Ontology:DOID:0080600); influenza, severe, susceptibility to (MONDO:MONDO:0013855)",
        "pathway": " (hsa:10410);  (R-HSA-909733)",
        "pathway_count": 2,
        "publication_count": 132,
        "publication_id_list": "10395669;10542297;10982844;11092454;11237011;11337497;11377645;11404376;11585831;12029096;12766484;12842042;14769151;15047845;15312780;15449939;15778442;16009940;16171819;16987978;17251292;1730654;17351669;17969444;18035202;18177740;18575461;18578522;1906403;19901966;20064371;20068231;20130243;20363976;20534863;20601941;20643137;20943977;21166591;21177806;21253575;22046135;2211721;22363774;22446628;22479637;22511783;23061660;23121362;23601107;23783831;24417533;24627473;25371710;25576301;26354436;27452731;28510447;29493099;29508533;30315122;30410026;30485383;30524438;30573663;30626607;30779550;30833945;30983867;31154438;31222486;31848261;32032529;32113509;32157095;32161166;32511913;32574262;32661006;32758689;32862111;32897882;32938616;32983136;33117408;33149299;33189161;33193462;33239446;33270927;33298915;33396578;33592498;33968037;34087483;34171305;34357683;34932366;35051231;35154160;35251023;35318648;35561310;35580925;36010968;36241641;37938771;38400050;38402626;38462163;38717821;38760017;6162102;6548414;688397;7510216;7526154;7537377;7540766;8197134;8232552;8605876;8621447;8702790;9096384;9121453;9242679;9334213;9660177;9842927;9847332;9861020",
        "class_list": "",
        "function": "Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB-dependent IFITM3 expression., [RefSeq, PubMed]; IFITM3 inhibits severe fever with thrombocytopenia syndrome virus entry and interacts with viral Gc protein., [RefSeq, PubMed]; IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed:26354436, PubMed:33239446, PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed:33270927). Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). Exerts opposing activities on SARS-CoV-2, including amphipathicity-dependent restriction of virus at endosomes and amphipathicity-independent enhancement of infection at the plasma membrane (PubMed:33270927)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Inflammatory Polymorphisms (IL-6 rs1800796, IL-10 rs1800896, TNF-alpha rs1800629, and IFITM3 rs12252) Are Not Associated with Post-COVID Symptoms in Previously Hospitalized COVID-19 Survivors. Publication Status: Online-Only, [RefSeq, PubMed]; Interferon-Induced Transmembrane Protein-3 Rs12252-G Variant Increases COVID-19 Mortality Potential in Egyptian Population., [RefSeq, PubMed]; Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]., [RefSeq]; Regulation of IFITM3 by TEF-1 demonstrates that TEF-1 dependent regulation is more widespread than its previously established role in the expression of muscle specific genes, [RefSeq, PubMed]; TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among severe COVID-19 ICU patients in Morocco., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53Y76;Q96HK8;Q96J15",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane",
        "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0006955 immune response;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0060337 type I interferon-mediated signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 13.5,
        "record_id": "Q01628-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14249-1",
        "uniprot_id": "NUCG_HUMAN",
        "mass": 32620.0,
        "length": 297,
        "protein_name": "Endonuclease G, mitochondrial",
        "gene_name": "ENDOG",
        "organism": "Human",
        "refseq_name": "endonuclease G, mitochondrial precursor",
        "refseq_ac": "NP_004426",
        "gene_names_uniprotkb": "ENDOG",
        "gene_names_refseq": "ENDOG",
        "protein_names_uniprotkb": "Endonuclease G, mitochondrial; 3.1.30.-; Endo G",
        "protein_names_refseq": "endo G; endonuclease G, mitochondrial precursor; endonuclease G, mitochondrial; mitochondrial endonuclease G",
        "tax_id": 9606,
        "disease": "nonsyndromic congenital nail disorder 3 (Disease Ontology:DOID:0080081); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); brain ischemia (Disease Ontology:DOID:2316); congestive heart failure (Disease Ontology:DOID:6000); muscular atrophy (Disease Ontology:DOID:767)",
        "pathway": " (hsa:2021)",
        "pathway_count": 1,
        "publication_count": 60,
        "publication_id_list": "12444964;15182854;22645359;23481700;24715725;25355512;25576301;26375851;26992070;27600516;27862975;28228285;28832583;28834231;29242379;29508533;29557506;29632711;29719607;29769354;29786170;30429286;31020640;31092671;31217245;31844290;31848261;32157095;32161166;32387766;32488085;32502341;32897882;32938616;33141586;33298915;33392160;33473107;33592498;33691108;33912179;33936100;33968037;34087483;34211107;34357683;34509645;34561969;34932366;35051231;35318648;35477840;35561310;35580925;36010968;36284347;36394256;36852641;39239896;7789991",
        "class_list": "",
        "function": "Apoptotic endonuclease EndoG induces alternative splicing of Caspase-2. Review article, [RefSeq, PubMed]; Assessment of the Role of Nuclear ENDOG Gene and mtDNA Variations on Paternal Mitochondrial Elimination (PME) in Infertile Men: An Experimental Study. Erratum:[Reprod Sci. 2022 Aug;29(8):2223. doi: 10.1007/s43032-022-00963-6. PMID: 35508586], [RefSeq, PubMed]; Endonuclease G and apoptosis-inducing factor are relocated and have roles in calcium induced signaling and oxidative stress-related impairment of mitochondria, [RefSeq, PubMed]; Endonuclease G promotes preeclampsia by regulating the Wnt signaling pathway., [RefSeq, PubMed]; Endonuclease that preferentially catalyzes the cleavage of double-stranded 5-hydroxymethylcytosine (5hmC)-modified DNA (PubMed:25355512). The 5hmC-modified nucleotide does not increase the binding affinity, but instead increases the efficiency of cutting and specifies the site of cleavage for the modified DNAs (By similarity). Shows significantly higher affinity for four-stranded Holliday junction over duplex and single-stranded DNAs (By similarity). Promotes conservative recombination when the DNA is 5hmC-modified (PubMed:25355512). Promotes autophagy through the suppression of mTOR by its phosphorylation-mediated interaction with YWHAG and its endonuclease activity-mediated DNA damage response (PubMed:33473107). GSK3-beta mediated phosphorylation of ENDOG enhances its interaction with YWHAG, leading to the release of TSC2 and PIK3C3 from YWHAG resulting in mTOR pathway suppression and autophagy initiation (PubMed:33473107). Promotes cleavage of mtDNA in response to oxidative and nitrosative stress, in turn inducing compensatory mtDNA replication (PubMed:29719607)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Examination of submitochondrial localization and its ability to cleave R-loops in order to clarify role in mtDNA replication, [RefSeq, PubMed]; REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC016351.1, X79444.1 and BC004922.2. This sequence is a reference standard in the RefSeqGene project. The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]., [RefSeq]; Unleashing a novel function of Endonuclease G in mitochondrial genome instability. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 6,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T281;Q9BSP2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042803 protein homodimerization activity;GO:0003676 nucleic acid binding;GO:0004520 DNA endonuclease activity;GO:0004521 RNA endonuclease activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0043204 perikaryon;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death;GO:0090297 positive regulation of mitochondrial DNA replication;GO:0006310 DNA recombination;GO:0071333 cellular response to glucose stimulus;GO:0071277 cellular response to calcium ion",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "Q14249-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TBM8-1",
        "uniprot_id": "DJB14_HUMAN",
        "mass": 42516.0,
        "length": 379,
        "protein_name": "DnaJ homolog subfamily B member 14",
        "gene_name": "DNAJB14",
        "organism": "Human",
        "refseq_name": "dnaJ homolog subfamily B member 14 isoform 1",
        "refseq_ac": "NP_001026893",
        "gene_names_uniprotkb": "DNAJB14; PRO34683",
        "gene_names_refseq": "DNAJB14; EGNR9427; PRO34683",
        "protein_names_uniprotkb": "DnaJ homolog subfamily B member 14",
        "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 14; dnaJ homolog subfamily B member 14 isoform 1; dnaJ homolog subfamily B member 14",
        "tax_id": 9606,
        "disease": "Huntington's disease (Disease Ontology:DOID:12858)",
        "pathway": " (hsa:79982)",
        "pathway_count": 1,
        "publication_count": 67,
        "publication_id_list": "11237011;12975309;21673190;23018488;23481700;24675744;24714562;24715725;24732912;25576301;25631089;25645385;25880248;26154972;26375851;26728094;26992070;27600516;27846572;27862975;27916661;27920218;28228285;28832583;28834231;29242379;29331515;29393594;29493099;29508533;29557506;29632711;29786170;29789417;30315122;30429286;30779550;31530632;31844290;31848261;32157095;32350084;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34932366;35051231;35318648;35561310;35580925;36010968;36241641;36284347;37925033;37938771",
        "class_list": "",
        "function": "(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744)., [UniProtKB, PubMed, PubMed]; Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912)., [UniProtKB, PubMed, PubMed, PubMed]; DNAJB12 and DNJB14 are non-redundant Hsp40 redox chaperones involved in endoplasmic reticulum protein reflux., [RefSeq, PubMed]; ER-located J-protein chaperones were identified as key regulators for the iogenesis and physiological function of ERG K+ channels. They regulate two distinct aspects of K+ channel biogenesis, the stabilization and assembly of channel subunits., [RefSeq, PubMed]; Over-expression of DNAJB12 or DNAJB14 causes the formation of elaborate membranous structures within cell nuclei, designated DJANGOS for DNAJ-associated nuclear globular structures. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6UXN1;Q7Z3P0;Q86TA7;Q86TM0;Q9GZU9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030544 Hsp70 protein binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006457 protein folding;GO:0071218 cellular response to misfolded protein;GO:0065003 protein-containing complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 6.8,
        "record_id": "Q8TBM8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H9Q4-1",
        "uniprot_id": "NHEJ1_HUMAN",
        "mass": 33337.0,
        "length": 299,
        "protein_name": "Non-homologous end-joining factor 1",
        "gene_name": "NHEJ1",
        "organism": "Human",
        "refseq_name": "non-homologous end-joining factor 1 isoform 1",
        "refseq_ac": "NP_079058",
        "gene_names_uniprotkb": "NHEJ1; XLF",
        "gene_names_refseq": "IMD124; MCOPCB13; NHEJ1; XLF",
        "protein_names_uniprotkb": "Non-homologous end-joining factor 1; Protein cernunnos; XRCC4-like factor",
        "protein_names_refseq": "XRCC4-like factor; non-homologous end-joining factor 1 isoform 1; nonhomologous end-joining factor 1; protein cernunnos",
        "tax_id": 9606,
        "disease": "severe combined immunodeficiency 124 (Disease Ontology:DOID:0061090); microphthalmia/coloboma 13 (MONDO:MONDO:0975809)",
        "pathway": " (hsa:79840);  (R-HSA-5693571)",
        "pathway_count": 2,
        "publication_count": 120,
        "publication_id_list": "10572166;10757784;11237011;11493912;11604075;11702069;11955432;12023295;12077346;12186630;12231622;12509254;12604777;12897153;12947387;14561766;15177042;15451442;15468306;15574327;15723659;16061182;16093244;16439204;16439205;16571728;16600297;16828027;16874298;16914548;17191205;17290226;17317666;17470781;17567543;17717001;18046455;18064046;18158905;18397950;18644470;19056826;19505854;20558749;20597108;21768349;21775435;21936820;22102241;22179609;22228831;22287571;22529269;22658747;23186163;23301498;23306437;23333306;23481700;23505375;23727112;24236237;24511403;25512557;25574025;25576301;25670504;25818648;25841101;25941166;26100018;26154972;26992070;27063109;27397612;27437582;27846572;27862975;28218747;28228285;28369633;28500754;28832583;28834231;29242379;29437277;29493099;29557506;29632711;29786170;30177755;30250067;30315122;30410026;30429286;30524438;31217245;31844290;31848261;31998317;32157095;32938616;32983136;33717175;33854234;34171305;34244791;34352203;35051231;35812385;36010968;36241641;37256950;37580330;37703920;8422676;9259561;9430729;9512523;9826654",
        "class_list": "",
        "function": "Cernunnos physically interacts with the XRCC4 x DNA-ligase IV complex, [RefSeq, PubMed]; Cernunnos-XLF is a new Non-homologous End Joining pathway protein, which if mutated results in several conditions -immunodeficiency and developmental anomalies and other conditions, which likely result from inability to repair spontaneous DNA damage., [RefSeq, PubMed]; Cernunnos/XRCC4-like factor promotes a mismatched end (MEnd) DNA ligase activity to facilitate joining and to preserve DNA sequence., [RefSeq, PubMed]; Cryo-EM of NHEJ supercomplexes provides insights into DNA repair., [RefSeq, PubMed]; DNA repair protein involved in DNA non-homologous end joining (NHEJ); it is required for double-strand break (DSB) repair and V(D)J recombination and is also involved in telomere maintenance (PubMed:16439204, PubMed:16439205, PubMed:17317666, PubMed:17470781, PubMed:17717001, PubMed:18158905, PubMed:18644470, PubMed:20558749, PubMed:26100018, PubMed:28369633). Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends (PubMed:17470781, PubMed:17717001, PubMed:19056826). Together with PAXX, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (PubMed:25670504, PubMed:30250067). May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary (PubMed:16439204, PubMed:16439205, PubMed:17317666, PubMed:17470781). In some studies, has been shown to associate with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:21768349, PubMed:21775435, PubMed:22228831, PubMed:22287571, PubMed:26100018, PubMed:27437582, PubMed:28500754). Alternatively, it has also been shown that rather than forming filaments, a single NHEJ1 dimer interacts through both head domains with XRCC4 to promote the close alignment of DNA ends (By similarity). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582, PubMed:28500754). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Binds DNA in a length-dependent manner (PubMed:17317666, PubMed:18158905)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; DNA repair protein involved in lymphocyte activation and cell division., [RefSeq, PubMed]; Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSeq, Jul 2008]., [RefSeq]; Mutational analysis of XLF and XRCC4 reveals a potential interaction interface, suggesting a mechanism for how XLF stimulates the ligation of mismatched ends., [RefSeq, PubMed]; PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Erratum:[Sci Adv. 2023 Sep 29;9(39):eadj8489. doi: 10.1126/sciadv.adj8489. PMID: 37774037], [RefSeq, PubMed]; Studies on the binding of XLF and its role in DNA repair. GeneRIF: The XLF-encoded protein (XRRC4 like factor, FLJ12610) is involved in DNA double-strand break repair via nonhomologous end-joining and associates with the Ligase IV-XRCC4 complex. XLF is mutated in a number of radiosensitive and immuno-deficient patients., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 51,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B8ZZA4;Q4ZFW7;Q6IA64;Q96JS9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0070182 DNA polymerase binding;GO:0045027 DNA end binding",
        "go_cellular_component": "GO:0070419 nonhomologous end joining complex;GO:0032807 DNA ligase IV complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center",
        "go_biological_process": "GO:0007417 central nervous system development;GO:0000723 telomere maintenance;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0010212 response to ionizing radiation;GO:0030183 B cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 12.3,
        "record_id": "Q9H9Q4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NV06-1",
        "uniprot_id": "DCA13_HUMAN",
        "mass": 51402.0,
        "length": 445,
        "protein_name": "DDB1- and CUL4-associated factor 13",
        "gene_name": "DCAF13",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DCAF13; HSPC064; WDSOF1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 13; WD repeat and SOF domain-containing protein 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:25879);  (R-HSA-6790901);  (R-HSA-6791226);  (R-HSA-8951664)",
        "pathway_count": 4,
        "publication_count": 250,
        "publication_id_list": "10.1101/2023.09.13.557529;10535940;10597293;10606270;10811609;10878807;10973499;11069780;11081632;11237011;11259415;11292861;11292862;11454738;11585840;11733065;11922599;11935223;11961546;11978965;12068309;12101228;12150911;12186903;12417735;12504025;12504026;12526791;12538644;12609982;12682069;12759363;12816948;14690597;14757770;15199136;15282312;15361859;15367669;15537541;15572695;15574592;15601839;15652483;15688063;15694336;15799966;16037817;16043514;16171779;16381836;16401342;16547496;16647857;16707496;16738141;16782898;16790436;16943200;16949367;17081101;17132228;17183367;17189298;17220875;17332328;17353269;17412707;17497243;17636026;17785452;18065403;18093314;18206966;18438418;18775313;18776931;18805092;18826954;18851830;18926707;18991276;19033376;19106111;19250909;19321346;19332556;19463982;19564402;19608861;19617556;19748355;19801658;20038530;20047967;20056613;20531386;20798176;20805244;20819938;21036871;21063389;21097556;21447816;21463634;21778237;21863050;21940857;22072790;22190735;22195017;22306028;22466964;22537386;22645359;22916032;22959436;23201271;23333871;23391857;23401859;23439679;23453757;23482395;23535662;23535663;23563313;23583660;2388630;23912815;23986495;24076655;24086612;24366543;24397554;24424021;24550520;24636985;24714562;24715725;24754225;24793695;24793696;25314029;25349211;25355947;25411247;25525153;25531226;25576301;25645385;25653167;25851604;25880248;25969445;26085946;26154972;26196125;26237581;26344709;26375851;26460955;26632597;26811146;26906416;26992070;27030794;27084949;27222660;27565346;27846572;27862975;27920218;28068668;28115426;28218747;28228285;28446606;28832583;28834231;28904123;29153394;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30111536;30283081;30315122;30379171;30410026;30429286;30524438;30610225;30779550;31217245;31492966;31530632;31844290;32005965;32157095;32284348;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33444648;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34105348;34171305;34185709;34211107;34516797;34725712;34932366;35051231;35083852;35318648;35561310;35580925;35932979;36241641;36284347;37938771;9211966;9482744;9512526;9790970;9887101;9891082",
        "class_list": "",
        "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Participates in the 18S rRNA processing in growing oocytes, being essential for oocyte nonsurrounded nucleolus (NSN) to surrounded nucleolus (SN) transition., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex that plays a key role in embryo preimplantation and is required for normal meiotic cycle progression in oocytes (PubMed:16949367, PubMed:30111536, PubMed:31492966). Acts as a maternal factor that regulates oocyte and zygotic chromatin tightness during maternal to zygotic transition (By similarity). Also involved in the transformation of the endometrium into the decidua, known as decidualization, providing a solid foundation for implantation of blastocysts (PubMed:35932979). Recognizes the histone methyltransferases SUV39H1 and SUV39H2 and directs them to polyubiquitination and proteasomal degradation, which facilitates the H3K9me3 removal and early zygotic gene expression, essential steps for progressive genome reprogramming and the establishment of pluripotency during preimplantation embryonic development (PubMed:30111536). Supports the spindle assembly and chromosome condensation during oocyte meiotic division by targeting the polyubiquitination and degradation of PTEN, a lipid phosphatase that inhibits PI3K pathway as well as oocyte growth and maturation (PubMed:31492966). Targets PMP22 for polyubiquitination and proteasomal degradation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3MII9;Q8NCH8;Q8TC51;Q96JY7;Q9NZX3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0030331 nuclear estrogen receptor binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0032040 small-subunit processome;GO:0080008 Cul4-RING E3 ubiquitin ligase complex;GO:1990904 ribonucleoprotein complex",
        "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006364 rRNA processing;GO:0040029 epigenetic regulation of gene expression;GO:0046697 decidualization",
        "synthesized_glycan_count": 0,
        "hit_score": 25.6,
        "record_id": "Q9NV06-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P10074-1",
        "uniprot_id": "ZBT48_HUMAN",
        "mass": 77054.0,
        "length": 688,
        "protein_name": "Zinc finger and BTB domain-containing protein 48",
        "gene_name": "ZBTB48",
        "organism": "Human",
        "refseq_name": "zinc finger and BTB domain-containing protein 48",
        "refseq_ac": "NP_001265576",
        "gene_names_uniprotkb": "ZBTB48; HKR3; TZAP; ZNF855",
        "gene_names_refseq": "HKR3; TZAP; ZBTB48; ZNF855; pp9964",
        "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 48; Krueppel-related zinc finger protein 3; TZAP; Telomere zinc finger-associated protein; Telomere-binding protein and transcriptional activator ZBTB48; Zinc finger protein 855; hKR3",
        "protein_names_refseq": "GLI-Kruppel family member HKR3; krueppel-related zinc finger protein 3; telomere zinc finger-associated protein; telomere-binding protein and transcriptional activator ZBTB48; telomeric zinc finger-associated protein; zinc finger and BTB domain-containing protein 48; zinc finger protein 855",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3104)",
        "pathway_count": 1,
        "publication_count": 36,
        "publication_id_list": "11237011;23481700;24275569;24382891;26375851;26992070;27920218;28082411;28500257;2850480;28832583;28834231;28904123;29242379;29393594;29493099;29632711;30524438;31154438;31844290;32157095;32938616;33592498;34833441;34932366;35051231;35318648;35561310;35580925;36556980;37217939;38253038;39300486;39562739;7969177;9516840",
        "class_list": "",
        "function": "Clinical Characteristics of TZAP (ZBTB48) in Hepatocellular Carcinomas from Tissue, Cell Line, and TCGA. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length (PubMed:28082411, PubMed:28500257). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28082411, PubMed:28500257). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:24382891, PubMed:28500257, PubMed:7969177). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891). Acts as a transcription regulator of CIITA, the major factor regulating MHC class II gene expression (PubMed:39562739). In addition, regulates cellular m6A/m6Am methylation on RNA by facilitating the recruitment of the RNA demethylase, FTO, to target mRNAs (PubMed:39300486)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Prognostic Value of Telomeric Zinc Finger-Associated Protein Expression in Adenocarcinoma and Squamous Cell Carcinoma of Lung. Publication Status: Online-Only, [RefSeq, PubMed]; Recruitment of the m[6]A/m6Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5SY19",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000976 transcription cis-regulatory region binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000781 chromosome, telomeric region",
        "go_biological_process": "GO:0051252 regulation of RNA metabolic process;GO:0010833 telomere maintenance via telomere lengthening;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "P10074-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P04440-1",
        "uniprot_id": "DPB1_HUMAN",
        "mass": 29159.0,
        "length": 258,
        "protein_name": "HLA class II histocompatibility antigen, DP beta 1 chain",
        "gene_name": "HLA-DPB1",
        "organism": "Human",
        "refseq_name": "HLA class II histocompatibility antigen, DP beta 1 chain precursor",
        "refseq_ac": "NP_002112",
        "gene_names_uniprotkb": "HLA-DPB1; HLA-DP1B",
        "gene_names_refseq": "DPB1; HLA-DP1B; HLA-DPB1; HLA-DPB; HLA-DP",
        "protein_names_uniprotkb": "HLA class II histocompatibility antigen, DP beta 1 chain; HLA class II histocompatibility antigen, DP(W4) beta chain; MHC class II antigen DPB1",
        "protein_names_refseq": "HLA class II histocompatibility antigen, DP beta 1 chain precursor; HLA class II histocompatibility antigen, DP beta 1 chain; HLA class II histocompatibility antigen, DP(W4) beta chain; HLA-DP histocompatibility type, beta-1 subunit; MHC HLA DPB1; MHC class II HLA-DP-beta-1; MHC class II antigen DPB1",
        "tax_id": 9606,
        "disease": "occupational asthma (Disease Ontology:DOID:0080820); graft-versus-host disease (Disease Ontology:DOID:0081267); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); pulmonary tuberculosis (Disease Ontology:DOID:2957); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); myelitis (Disease Ontology:DOID:322); liver disease (Disease Ontology:DOID:409); cervical cancer (Disease Ontology:DOID:4362); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); lung disease (Disease Ontology:DOID:850); narcolepsy (Disease Ontology:DOID:8986); allergic asthma (Disease Ontology:DOID:9415); type 1 diabetes mellitus (Disease Ontology:DOID:9744)",
        "pathway": " (hsa:3115);  (R-HSA-202424);  (R-HSA-202427);  (R-HSA-202430);  (R-HSA-202433);  (R-HSA-2132295);  (R-HSA-389948);  (R-HSA-877300)",
        "pathway_count": 8,
        "publication_count": 296,
        "publication_id_list": "10.1101/2023.09.13.557529;10036229;10064083;10067896;10072072;10090623;10480952;10540230;10593899;10631941;10631952;10639150;10671560;10698680;10716940;10747096;10748235;10790433;10809954;10811803;10958363;10986460;11048639;11169249;11237011;11358993;11390650;11529500;11556983;11607830;11684289;11752630;11782281;11790530;11813165;11827988;11853874;11884229;11972023;12040185;12078484;12135440;12198549;12438563;12446674;12473184;12485116;12660731;12694578;12742663;12748383;12890000;12890001;12893276;12915721;12938237;12947224;1358867;1396683;1412421;1440570;14510693;14514672;14586410;14722222;14731593;1481203;15084594;1508672;15122200;15125833;15140044;15143187;15145317;1529429;15322115;15358536;15361132;15371334;15388922;15489910;15489916;15530433;15541657;15749704;15911768;15982263;16056267;16147881;16181339;16189666;16237089;16242130;16356853;16356855;16364187;16461343;16467876;16612002;16618111;16824007;16866899;16978534;17047224;17072321;17125875;17135271;17142755;17241953;17283181;17363905;17468049;17496917;17548359;17652306;17728323;18046453;18173375;18292509;18362138;18591661;18759926;19092054;19533806;1956401;19564404;19775376;20049711;20130243;20304997;20346773;20363976;21116285;21154117;2121367;21441454;21543337;2190094;22426112;2242906;23061660;23302904;23328677;23580664;2391366;24190977;24417533;2460556;24715725;2530588;25502872;25505266;25880248;26154972;26992070;2714855;27846572;28165004;28265006;2838415;28467828;28904123;29557506;29741879;29863979;2987832;2998758;30315122;3036829;30522017;30573663;31217245;31313098;31844290;32157095;32162841;32265295;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33043033;33091337;33141586;33239784;33298915;33392160;33592498;33633747;33912179;33936100;33968037;34078123;34087483;34171305;34185709;34211107;34357683;34433824;34509645;34932366;35051231;35154160;35561310;35580925;36074540;36394166;36411507;37074911;37938771;37980631;38040271;6098459;6310612;6330724;7479848;7481823;7510216;7514165;7530745;7565724;7592972;7615558;7617032;7638863;7650016;7657660;7667286;7673114;7690989;7743181;7744621;7796299;7806296;7817379;7839356;7901923;7912859;8046351;8085260;8134367;8145819;8148318;8156998;8176225;8313912;8344726;8360479;8397411;8415765;8483949;8520027;8525482;8530158;8550590;8550631;8598037;8601309;8631301;8642258;8687433;8773318;8781129;8798379;8824162;8824201;8849454;8851734;8896187;8909537;8939989;8947036;9075930;9111318;9115214;9143706;9174146;9202021;9252186;9311912;9312039;9362451;9497313;9539769;9545226;9606180;9687533;9694359;9756410;9756411;9846482;9850860;9990853",
        "class_list": "",
        "function": "Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading., [UniProtKB]; Characterization of the novel HLA-DPB1*11:01:06 allele by sequencing-based typing., [RefSeq, PubMed]; Characterization of the novel HLA-DPB1*1348:01 allele by sequencing-based typing., [RefSeq, PubMed]; HLA sequencing identifies novel associations and suggests clinical relevance of DPB1*04:01 in ANCA-associated Granulomatosis with polyangiitis., [RefSeq, PubMed]; HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]., [RefSeq]; The effect of HLA-DP gene polymorphisms in Plasmodium Vivax-induced malaria susceptibility., [RefSeq, PubMed]; The novel HLA-DPB1 allele, HLA-DPB1*1344:01, first identified in Korean individuals by next-generation sequencing., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 8796,
        "biomarker_type": "",
        "glycan_count": 44,
        "disease_count": 18,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0PFJ7;A5I886;A8YPB3;B5U8B4;B7VF80;B7VF87;B8ZX68;B8ZYT0;B9W5S8;B9W6F7;B9W6F9;C0MPP5;C0MPQ2;C0MPQ3;C0MPQ5;C0MPQ6;C0MPQ7;C4R9J5;C5IZL1;O00259;O19698;O19700;O19702;O19749;O46884;O77952;O98215;O98216;O98217;O98218;O98219;O98222;O98223;P01916;P04232;P13763;P79493;P79608;Q0P0L4;Q0ZFN3;Q14279;Q27S71;Q29682;Q29684;Q29698;Q29714;Q29775;Q29776;Q29778;Q29779;Q29781;Q29827;Q29828;Q29879;Q29880;Q29898;Q29977;Q2MGW3;Q30015;Q30031;Q30032;Q30033;Q30034;Q30050;Q30051;Q30052;Q30053;Q30054;Q30055;Q30174;Q4GY31;Q4JHD8;Q5ENE0;Q5ENE1;Q5ENW3;Q5EP46;Q5EP47;Q5EP49;Q5EP51;Q5EP52;Q5EP53;Q5EP56;Q5I4H8;Q5I4H9;Q5ISH4;Q5ISH5;Q5SQ73;Q5STP2;Q5YLA6;Q6IVX1;Q6LBX2;Q6LBX3;Q6LBX4;Q6LBX5;Q6LBX6;Q6LBX7;Q6PWX6;Q6TAS4;Q714U1;Q714U2;Q7YQ10;Q860Z7;Q8HWL7;Q8HWT5;Q8SNC4;Q95HC1;Q95IT7;Q95IT8;Q9BD13;Q9GIM2;Q9GIM4;Q9GIX6;Q9GJ41;Q9MY67;Q9TNT7;Q9TQE2;Q9XS11;Q9XS12",
        "ec_number_list": "",
        "go_molecular_function": "GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030054 cell junction",
        "go_biological_process": "GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0050852 T cell receptor signaling pathway;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0002250 adaptive immune response;GO:0032729 positive regulation of type II interferon production",
        "synthesized_glycan_count": 0,
        "hit_score": 34.2,
        "record_id": "P04440-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P49184-1",
        "uniprot_id": "DNSL1_HUMAN",
        "mass": 33893.0,
        "length": 302,
        "protein_name": "Deoxyribonuclease-1-like 1",
        "gene_name": "DNASE1L1",
        "organism": "Human",
        "refseq_name": "deoxyribonuclease-1-like 1 precursor",
        "refseq_ac": "NP_001009932",
        "gene_names_uniprotkb": "DNASE1L1; DNAS1L1; DNL1L",
        "gene_names_refseq": "DNAS1L1; DNASE1L1; DNASEX; DNL1L; G4.8; XIB",
        "protein_names_uniprotkb": "Deoxyribonuclease-1-like 1; 3.1.21.-; DNase I-like 1; DNase X; Deoxyribonuclease I-like 1; Muscle-specific DNase I-like; XIB",
        "protein_names_refseq": "DNase I, lysosomal-like; DNase I-like 1; DNase I-like, muscle-specific; deoxyribonuclease I-like 1; deoxyribonuclease-1-like 1 precursor",
        "tax_id": 9606,
        "disease": "Bartter disease type 2 (Disease Ontology:DOID:0110143); nephrotic syndrome (Disease Ontology:DOID:1184)",
        "pathway": " (hsa:1774);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 33,
        "publication_id_list": "11237011;16107205;17180083;23650620;24715725;26154972;26992070;27846572;29557506;30429286;30779550;31092671;31154438;31844290;31848261;32350084;32387766;32488085;32897882;32938616;33592498;33968037;34171305;34185709;35251023;35580925;36241641;36284347;36628843;8541839;8654957;8692836;8733135",
        "class_list": "",
        "function": "Analysis of tafazzin and deoxyribonuclease 1 like 1 transcripts and X chromosome sequencing in the evaluation of the effect of mosaicism in the TAZ gene on phenotypes in a family affected by Barth syndrome., [RefSeq, PubMed]; This gene encodes a deoxyribonuclease protein that shows high sequence similarity to DNase I. The encoded protein is localized to the endoplasmic reticulum and modified by N-linked glycosylation. Alternate transcriptional splice variants encoding the same protein have been observed. [provided by RefSeq, Jan 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DWW7;Q5HY41",
        "ec_number_list": "1.8.3.2;2.7.1.35;3.4.21.-;3.5.3.1;3.4.23.5;3.4.21.37;2.3.1.16;2.3.1.9;2.3.1.155;1.4.3.22;1.4.3.-;3.4.24.34;3.1.3.48;2.7.10.2;3.1.21.-;3.6.5.2;3.2.1.17;3.2.1.14;2.3.2.5;3.6.1.6;3.4.19.9;3.2.1.18;3.5.1.3;3.4.18.1;3.2.1.166",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0004536 DNA nuclease activity;GO:0004530 deoxyribonuclease I activity;GO:0016787 hydrolase activity;GO:0004519 endonuclease activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0035580 specific granule lumen",
        "go_biological_process": "GO:0006259 DNA metabolic process;GO:0006308 DNA catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "P49184-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9P219-1",
        "uniprot_id": "DAPLE_HUMAN",
        "mass": 228230.0,
        "length": 2028,
        "protein_name": "Protein Daple",
        "gene_name": "CCDC88C",
        "organism": "Human",
        "refseq_name": "protein Daple",
        "refseq_ac": "NP_001073883",
        "gene_names_uniprotkb": "CCDC88C; DAPLE; KIAA1509",
        "gene_names_refseq": "CCDC88C; DAPLE; HKRP2; HYC1; KIAA1509; SCA40",
        "protein_names_uniprotkb": "Protein Daple; Coiled-coil domain-containing protein 88C; Dvl-associating protein with a high frequency of leucine residues; HkRP2; Hook-related protein 2; hDaple",
        "protein_names_refseq": "Dvl-associating protein with a high frequency of leucine residues; coiled-coil domain containing 88C; hook-related protein 2; protein Daple; spinocerebellar ataxia 40",
        "tax_id": 9606,
        "disease": "spinocerebellar ataxia 40 (Disease Ontology:DOID:0050986); congenital hydrocephalus (Disease Ontology:DOID:0070681); congenital hydrocephalus 1 (Disease Ontology:DOID:0070682); hydrocephalus (Disease Ontology:DOID:10908)",
        "pathway": " (hsa:440193);  (R-HSA-5368598)",
        "pathway_count": 2,
        "publication_count": 98,
        "publication_id_list": "10944533;11237011;14750955;15108311;15882442;18452278;18669648;19651622;19690332;20068231;21031079;22544926;22643886;23042809;23186163;23481700;24714562;24715725;25062847;25576301;26126266;26154972;26375851;26811146;26992070;27846572;27862975;27920218;28063628;28228285;28832583;28834231;28904123;29021338;29237092;29242379;29331515;29393594;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30059200;30194280;30315122;30379171;30429286;30524438;30948426;31217245;31492838;31844290;32058970;32157095;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32938750;32983136;33123756;33141586;33298915;33392160;33592498;33691108;33912179;33936100;33968037;33981976;34019948;34087483;34092257;34171305;34211107;34509645;34932366;35051231;35254053;35513511;35561310;35580925;36010968;36241641;36284347;36768938;37317935;37340703;37899026;37938771;38173219;39531497",
        "class_list": "",
        "function": "A Novel c.3636-4 A>G Mutation in the CCDC88C Plays a Causative Role in Familial Spinocerebellar Ataxia., [RefSeq, PubMed]; CCDC88C variants are associated with focal epilepsy and genotype-phenotype correlation., [RefSeq, PubMed]; Confirmation of the Pathogenetic Role of the CCDC88C Gene in Early-Onset Pure Spastic Paraplegia., [RefSeq, PubMed]; Neuropathological hallmarks of fetal hydrocephalus linked to CCDC88C pathogenic variants. Publication Status: Online-Only, [RefSeq, PubMed]; Our data validate CCDC88C as causing autosomal recessive, primary non-syndromic congenital hydrocephalus, suggesting this gene may be an important cause of congenital hydrocephalus., [RefSeq, PubMed]; Required for activation of guanine nucleotide-binding proteins (G proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426)., [UniProtKB, PubMed, PubMed]; Spinocerebellar Ataxia in a Hungarian Female Patient with a Novel Variant of Unknown Significance in the CCDC88C Gene. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. The protein encoded by this gene has a PDZ-domain binding motif in its C-terminus with which it interacts with the dishevelled protein. Dishevelled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus; a condition characterized by excessive accumulation of cerebrospinal fluid in the ventricles of the brain. [provided by RefSeq, Jan 2013]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 17,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 57,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q69YK1;Q7L1M2;Q86SX7;Q8IYG8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005109 frizzled binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0001965 G-protein alpha-subunit binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0030054 cell junction;GO:0043296 apical junction complex",
        "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0007264 small GTPase-mediated signal transduction;GO:0031648 protein destabilization;GO:0030705 cytoskeleton-dependent intracellular transport",
        "synthesized_glycan_count": 0,
        "hit_score": 10.7,
        "record_id": "Q9P219-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H069-1",
        "uniprot_id": "DRC3_HUMAN",
        "mass": 61054.0,
        "length": 523,
        "protein_name": "Dynein regulatory complex subunit 3",
        "gene_name": "DRC3",
        "organism": "Human",
        "refseq_name": "dynein regulatory complex subunit 3 isoform a",
        "refseq_ac": "NP_001123562",
        "gene_names_uniprotkb": "DRC3; LRRC48",
        "gene_names_refseq": "CFAP134; DRC3; LRRC48",
        "protein_names_uniprotkb": "Dynein regulatory complex subunit 3; Leucine-rich repeat-containing protein 48",
        "protein_names_refseq": "dynein regulatory complex subunit 3 isoform a; leucine rich repeat containing 48; leucine-rich repeat-containing protein 48",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:83450)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11230166;11237011;23354437;24715725;27120127;29351928;29557506;30379171;31844290;34087483;34169321;35051231;35580925;36627292",
        "class_list": "",
        "function": "Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes., [UniProtKB, UniProtKB]; DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KAE6;Q86SF9;Q86W73;Q8IWG0",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0097545 axonemal doublet microtubule",
        "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0003341 cilium movement",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q9H069-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P05538-1",
        "uniprot_id": "DQB2_HUMAN",
        "mass": 30387.0,
        "length": 268,
        "protein_name": "HLA class II histocompatibility antigen, DQ beta 2 chain",
        "gene_name": "HLA-DQB2",
        "organism": "Human",
        "refseq_name": "HLA class II histocompatibility antigen, DQ beta 2 chain isoform 2 precursor",
        "refseq_ac": "NP_001185787",
        "gene_names_uniprotkb": "HLA-DQB2; HLA-DXB",
        "gene_names_refseq": "DQB2; HLA-DQB1; HLA-DQB2; HLA-DXB",
        "protein_names_uniprotkb": "HLA class II histocompatibility antigen, DQ beta 2 chain; HLA class II histocompatibility antigen, DX beta chain; MHC class II antigen DQB2",
        "protein_names_refseq": "DV19.1 (major histocompatibility complex, class II, DQ beta 2 (HLA-DXB)); HLA class II histocompatibility antigen, DQ beta 2 chain isoform 2 precursor; HLA class II histocompatibility antigen, DQ beta 2 chain; HLA class II histocompatibility antigen, DX beta chain; MHC class II antigen DQB2",
        "tax_id": 9606,
        "disease": "pneumocystosis (Disease Ontology:DOID:11339); uveitis (Disease Ontology:DOID:13141)",
        "pathway": " (hsa:3120);  (R-HSA-202424);  (R-HSA-202427);  (R-HSA-202430);  (R-HSA-202433);  (R-HSA-2132295);  (R-HSA-389948);  (R-HSA-877300)",
        "pathway_count": 8,
        "publication_count": 218,
        "publication_id_list": "10.1101/2023.09.13.557529;10036229;10064083;10067896;10072072;10480952;10540230;10593899;10631941;10631952;10639150;10671560;10698680;10716940;10747096;10748235;10790433;10809954;10811803;10986460;11048639;11237011;11334674;11358993;11390650;11529500;11607830;11684289;11752630;11790530;11813165;11827988;11853874;11884229;11972023;12040185;12078484;12198549;12438563;12446674;12473184;12485116;12660731;12742663;12748383;12893276;12915721;12938237;12947224;1396683;14510693;14514672;14586410;14722222;14731593;15084594;1508672;15122200;15125833;15143187;15145317;15322115;15358536;15371334;15388922;15489910;15489916;15530433;15541657;15749704;15911768;16056267;16181339;16237089;16242130;16356853;16356855;16364187;16461343;16467876;16612002;16618111;16824007;16978534;17047224;17072321;17125875;17135271;17142755;17241953;17283181;17363905;17468049;17496917;17548359;17652306;17728323;18046453;18173375;18292509;18362138;18591661;18759926;19092054;19533806;1956401;19564404;20049711;20130243;20304997;20346773;20363976;21116285;21154117;2121367;21441454;21543337;2190094;22407913;22426112;23061660;23302904;23580664;2391366;24190977;24417533;2530588;25418920;2564844;26811146;27394003;28165004;28265006;28613373;28904123;29493099;29557506;29863979;3036828;30522017;30600606;31217245;31313098;31844290;32350084;32897882;32938616;32983136;33141586;33239784;33592498;33691108;33936100;33968037;34509645;35051231;35154160;35580925;3858830;7479848;7481823;7510216;7514165;7530745;7565724;7592972;7615558;7617032;7650016;7657660;7667286;7673114;7690989;7796299;8046351;8134367;8145819;8148318;8156998;8176225;8313912;8397411;8415765;8483949;8520027;8530158;8550590;8550631;8568858;8598037;8601309;8631301;8642258;8687433;8798379;8824201;8849454;8909537;8939989;8947036;9036956;9075930;9111318;9115214;9143706;9202021;9252186;9311912;9312039;9362451;9497313;9539769;9545226;9606180;9687533;9846482;9850860;9990853",
        "class_list": "",
        "function": "Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading., [UniProtKB, PubMed]; HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus. [provided by RefSeq, Oct 2010]., [RefSeq]; No statistically significant association was found between rs7453920 SNP and chronic hepatitis B. Publication Status: Online-Only, [RefSeq, PubMed]; The functional HLA-DQB2 rs7453920 G>A polymorphism may contribute to the genetic susceptibility to pulmonary tuberculosis in the Chinese Uygur population., [RefSeq, PubMed]; This study shows that HLA-DQ gene polymorphisms are associated with ankylosing spondylitis in Southwest China, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NIA5;Q29826;Q29870;Q29871;Q29872;Q29873;Q5SR06",
        "ec_number_list": "",
        "go_molecular_function": "GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding;GO:0032395 MHC class II receptor activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane;GO:0005765 lysosomal membrane;GO:0030658 transport vesicle membrane",
        "go_biological_process": "GO:0006955 immune response;GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0002250 adaptive immune response;GO:0050870 positive regulation of T cell activation",
        "synthesized_glycan_count": 0,
        "hit_score": 22.1,
        "record_id": "P05538-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14186-1",
        "uniprot_id": "TFDP1_HUMAN",
        "mass": 45070.0,
        "length": 410,
        "protein_name": "Transcription factor Dp-1",
        "gene_name": "TFDP1",
        "organism": "Human",
        "refseq_name": "transcription factor Dp-1",
        "refseq_ac": "NP_009042",
        "gene_names_uniprotkb": "TFDP1; DP1",
        "gene_names_refseq": "DILC; DP1; DRTF1; Dp-1; TFDP1",
        "protein_names_uniprotkb": "Transcription factor Dp-1; DRTF1-polypeptide 1; DRTF1; E2F dimerization partner 1",
        "protein_names_refseq": "DRTF1-polypeptide 1; E2F dimerization partner 1; E2F-related transcription factor; down-regulated in liver cancer stem cells; transcription factor Dp-1",
        "tax_id": 9606,
        "disease": "mismatch repair cancer syndrome (Disease Ontology:DOID:0112182)",
        "pathway": " (hsa:7027);  (R-HSA-111448);  (R-HSA-113501);  (R-HSA-1362277);  (R-HSA-1362300);  (R-HSA-139915);  (R-HSA-1538133);  (R-HSA-1912408);  (R-HSA-2173796);  (R-HSA-2559580);  (R-HSA-2559585);  (R-HSA-6804114);  (R-HSA-69202);  (R-HSA-69205);  (R-HSA-69231);  (R-HSA-69656);  (R-HSA-8953750);  (R-HSA-9616222);  (R-HSA-9661069)",
        "pathway_count": 19,
        "publication_count": 368,
        "publication_id_list": "10022869;10199400;10207050;10228158;10233885;10323868;10330422;10347217;10358095;10375532;10385618;10454565;10454584;10499802;10524633;10597240;10692433;10722742;10772813;10807576;10831586;10871633;11003670;11007770;11013220;11032757;11073976;11157749;11171983;11231573;11231585;11234019;11237011;11242107;11274402;11340171;11369759;11416152;11424093;11427533;11463392;11564866;11572983;11574543;11585773;11684017;11719808;11782450;11867521;11883935;11884610;11907280;11959842;11988738;12004135;12134156;12150994;12189133;12193592;12242300;12421820;12435631;12435635;12444543;12446674;12702500;12730199;12782299;12808055;12869508;12909625;12917425;1312467;13130464;1396589;1423597;14507994;14517214;14517297;14527418;14532106;14597415;14657019;14684737;14729966;14729977;14766746;14990995;14991602;15014447;15100235;15150273;15186775;15287722;15469821;15472075;15510213;15536069;15563468;15572696;15574328;15579463;15684396;15866172;16186825;16195327;16211008;16278212;16319104;16337592;16436515;16582612;16612405;16751774;16772293;16782892;16826196;17001316;17063141;17092340;17172876;17210787;17254966;17254967;17254968;17255097;17322306;17332741;17344414;17344417;17395714;17438144;17531812;17540598;17540599;17554337;17562868;17600109;17685488;17699597;17719541;17765224;17823410;17825402;17875933;17908796;17991896;1826560;1828392;1828393;1828394;1831692;18365017;18414028;18562691;18568018;18669648;18676979;18710949;18767875;18776924;18793328;18827403;19007248;19075005;19150886;19413330;19451217;19451218;19458076;19462008;19487459;19528227;19608861;19651622;19661920;19664994;19664995;19690332;19714243;19723635;19773441;19896182;19914168;20058876;20068231;20080834;20090754;20107323;20176812;20351093;20442293;20442780;20460379;20495621;20534573;20595680;20661648;20663872;20801121;20805998;20843055;20952511;21280156;21402699;21406692;21423214;21471526;21498570;21551231;21596310;21602795;21715330;21875955;21986495;21993314;22020331;22110129;22275377;22325352;22336108;22371011;22474248;22683641;23001182;23007395;23186163;23365256;23481700;23485469;23622515;23737759;23954429;24096481;24366607;24379003;24515438;24584857;24627085;24714562;24715725;24876129;2524830;25418920;25469497;25576301;25733683;25784653;26154972;26728094;26977885;26992070;2721961;27846572;27920218;28218747;28228285;28832583;28904123;29101237;29242379;29431622;29508533;29557506;29632711;29786170;30484775;30711375;31543423;31844290;31936902;32157095;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33691108;33717175;33912179;33936100;34171305;34211107;35051231;36010968;36215666;36284347;37715794;38614125;7535770;7588608;7588633;7623816;7629134;7739537;7743995;7784094;7797074;7799941;7816143;7859739;7862113;7929342;7954814;7973727;8001816;8039504;8050359;8078588;8114698;8114739;8139570;8246996;8259215;8288595;8319905;8336704;8405995;8413249;8497257;8552081;8618861;8622669;8622688;8626550;8695841;8700224;8741839;8774846;8846784;8846917;8878478;8943353;8974401;9020173;9030721;9042862;9106657;9144196;9162092;9177240;9190208;9195981;9199292;9325318;9342358;9447971;9448290;9482921;9501179;9508775;9520412;9529249;9564042;9628874;9632134;9659898;9662327;9689056;9693032;9704927;9724731;9768359;9778043;9824166;9891042",
        "class_list": "",
        "function": "Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:7739537, PubMed:8405995). The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812)., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]., [RefSeq]; Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer. Publication Status: Online-Only, [RefSeq, PubMed]; ZNF146 regulates cell cycle progression via TFDP1 and DEPDC1B in ovarian cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DLQ9;Q5JSB4;Q8IZL5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0140297 DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex",
        "go_biological_process": "GO:0070345 negative regulation of fat cell proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 36.9,
        "record_id": "Q14186-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NX74-1",
        "uniprot_id": "DUS2_HUMAN",
        "mass": 55050.0,
        "length": 493,
        "protein_name": "tRNA-dihydrouridine(20) synthase [NAD(P)+]-like",
        "gene_name": "DUS2",
        "organism": "Human",
        "refseq_name": "tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 1",
        "refseq_ac": "NP_001258691",
        "gene_names_uniprotkb": "DUS2; DUS2L",
        "gene_names_refseq": "DUS2L; DUS2; SMM1; URLC8",
        "protein_names_uniprotkb": "tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; 1.3.1.91; Dihydrouridine synthase 2; URLC8; Up-regulated in lung cancer protein 8; hDUS2; tRNA-dihydrouridine synthase 2-like",
        "protein_names_refseq": "dihydrouridine synthase 2-like, SMM1 homolog; tRNA-dihydrouridine(20) synthase (NAD(P)(+)); tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 1; up-regulated in lung cancer protein 8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54920);  (R-HSA-6782315);  (R-HSA-9833482)",
        "pathway_count": 3,
        "publication_count": 249,
        "publication_id_list": "10082513;10348343;10400669;10430867;10620360;10626894;10648614;10848580;10866685;10982862;11027153;11096080;11111046;11134010;11152499;11156368;11237011;11238103;11238927;11278865;11313968;11337501;11350938;11438540;11500375;11781817;11909525;11939789;11985496;12231563;12397061;12403464;12882984;1373135;14585331;15229216;15299030;15737233;15752359;15861136;15870694;15907845;15994936;16043508;16179258;16179259;16373505;16424344;16431927;16600570;16717090;1695551;16982605;17071714;17079286;17196820;17322306;18096616;18567810;18669648;18835251;18957415;19017811;19229320;19413330;19414587;19416861;19710021;19733181;19804757;19838063;20068231;20123966;20308323;20354154;20395957;20519500;20584901;20685959;21059936;21072047;21123651;21131277;21294215;21518807;21636578;21937648;21978664;21994559;22214662;22344696;22424782;22442237;2247437;22591353;22986343;22995836;23042678;23048041;23084476;23186163;23229543;23381944;23481700;23604283;23732991;24126054;24204302;24347309;24366607;24623135;24659800;24714562;24715725;24753571;24901367;25261850;25404562;25576301;25653431;25848059;25916855;26143927;26154972;26160102;26310293;26375851;26429968;26432638;26446704;26488609;26716879;26728094;26817845;26992070;27055666;27208315;27269119;27423063;27600516;27846572;27893789;27920218;27974558;28063628;28069888;28167698;28228285;28281686;28514659;28765891;28832583;28834231;28904123;29170442;29175459;29231267;29242379;29348664;29393594;29394925;29395325;29440070;29501855;29508533;29557506;29632046;29632711;30149704;30174290;30315122;30524438;30605527;30770398;30779550;30833945;31031002;31217245;31222486;31481669;31844290;31937595;31998317;32093270;32157095;32161166;32357974;32387766;32488085;32502341;32716602;32801355;32897882;32938616;32983136;33141586;33298915;33392160;33717175;33808629;33911136;33912179;33936100;33968037;33981976;34087483;34171305;34174402;34211107;34357683;34405274;34509645;34798057;34974812;35051231;35318648;35685460;35947956;36010968;36215666;36241641;36284347;36610787;36712380;37127961;38680565;7491766;7515177;7545299;7565688;7693978;7737357;7903669;8576172;8576179;8661426;8810342;8910500;9034343;9079663;9430663;9442054;9521856;9528799;9687506;9737981;9819388;9851972;9920933",
        "class_list": "",
        "function": "Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:15994936, PubMed:26429968, PubMed:30149704, PubMed:34798057, PubMed:38680565). Specifically modifies U20 in cytoplasmic tRNAs (PubMed:38680565). Activity depends on the presence of guanosine at position 19 in the tRNA substrate (PubMed:38680565). Negatively regulates the activation of EIF2AK2/PKR (PubMed:18096616)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Crystals belonged to space group P2(1) and contained a single molecule of HsDus2L in the asymmetric unit, [RefSeq, PubMed]; HDUS2 interacts with protein kinase PKR through its dsRNA binding/dimerization domain and inhibits its kinase activity., [RefSeq, PubMed]; This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]., [RefSeq]; This is the first reported case of a tRNA-modifying enzyme (dihydrouridine synthase 2) carrying a dsRNA binding domain used to bind tRNAs., [RefSeq, PubMed]; We establish that while hDus2 dsRBD retains a conventional dsRNA recognition capability, the presence of an N-terminal extension appended to the canonical domain provides additional residues for binding tRNA in a structure-specific mode of action., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K3G3;Q4H4D9",
        "ec_number_list": "3.6.4.10;2.7.10.2;2.7.11.1;3.5.4.37;3.6.4.13;2.3.2.27;1.3.1.91;2.7.1.91;2.3.1.-",
        "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0000049 tRNA binding;GO:0004860 protein kinase inhibitor activity;GO:0003725 double-stranded RNA binding;GO:0070402 NADPH binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol",
        "go_biological_process": "GO:0002943 tRNA dihydrouridine synthesis;GO:0140374 antiviral innate immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 25.0,
        "record_id": "Q9NX74-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96II8-1",
        "uniprot_id": "LRCH3_HUMAN",
        "mass": 86083.0,
        "length": 777,
        "protein_name": "DISP complex protein LRCH3",
        "gene_name": "LRCH3",
        "organism": "Human",
        "refseq_name": "DISP complex protein LRCH3 isoform 2",
        "refseq_ac": "NP_116162",
        "gene_names_uniprotkb": "LRCH3",
        "gene_names_refseq": "LRCH3",
        "protein_names_uniprotkb": "DISP complex protein LRCH3; Leucine-rich repeat and calponin homology domain-containing protein 3",
        "protein_names_refseq": "DISP complex protein LRCH3 isoform 2; DISP complex protein LRCH3; leucine-rich repeat and calponin homology domain-containing protein 3; leucine-rich repeats and calponin homology (CH) domain containing 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84859)",
        "pathway_count": 1,
        "publication_count": 62,
        "publication_id_list": "11237011;18669648;19367720;19690332;20068231;23186163;23481700;24275569;24366607;24715725;25505266;25576301;25645385;26154972;26992070;27600516;27846572;28228285;28832583;28860189;28904123;29242379;29467281;29508533;29557506;29786170;30429286;30524438;31217245;31611695;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33691108;33717175;33912179;33968037;33981976;34087483;34171305;34211107;34357683;34405274;34509645;34561969;35051231;35318648;35580925;36010968;36241641;36284347;37938771",
        "class_list": "",
        "function": "As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E0T7;Q96FP9;Q9NT52",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0032185 septin cytoskeleton organization;GO:0031106 septin ring organization",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "Q96II8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P48730-1",
        "uniprot_id": "KC1D_HUMAN",
        "mass": 47330.0,
        "length": 415,
        "protein_name": "Casein kinase I isoform delta",
        "gene_name": "CSNK1D",
        "organism": "Human",
        "refseq_name": "casein kinase I isoform delta isoform 1",
        "refseq_ac": "NP_001884",
        "gene_names_uniprotkb": "CSNK1D; HCKID",
        "gene_names_refseq": "ASPS; CKI-delta; CKIdelta; CKId; CSNK1D; FASPS2; HCKID",
        "protein_names_uniprotkb": "Casein kinase I isoform delta; 2.7.11.1; 2.7.11.26; CKI-delta; CKId; Tau-protein kinase CSNK1D",
        "protein_names_refseq": "casein kinase I isoform delta isoform 1; tau-protein kinase CSNK1D",
        "tax_id": 9606,
        "disease": "syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); advanced sleep phase syndrome 2 (Disease Ontology:DOID:0110012); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); thrombocytopenia (Disease Ontology:DOID:1588); colon cancer (Disease Ontology:DOID:219); hyperglycemia (Disease Ontology:DOID:4195)",
        "pathway": " (hsa:1453);  (R-HSA-204005);  (R-HSA-2565942);  (R-HSA-380259);  (R-HSA-380270);  (R-HSA-380284);  (R-HSA-380320);  (R-HSA-5620912);  (R-HSA-6791226);  (R-HSA-8854518);  (R-HSA-9931521);  (R-HSA-9931530)",
        "pathway_count": 12,
        "publication_count": 284,
        "publication_id_list": "10445031;10559959;10606744;10679020;10747087;10788476;10790862;10825291;10826492;10903204;10982397;11035026;11076968;11161704;11165242;11232563;11237011;11285137;11306556;11922599;11927603;11956313;12068309;12070132;12150911;12207013;12221128;12235121;12270714;12270943;12364337;12852856;13678582;14580337;14654843;14750904;14761950;15037235;15070676;15498487;15705883;15800623;16027726;16037817;16043514;16303754;16357211;16462731;16495487;16618118;16624868;16738141;16890155;16912714;16959974;17005010;17038314;17081983;17189298;17192257;17192411;17287728;17316621;17344846;17353269;17412707;17562708;17562788;17574030;17594292;17646400;17684057;17719545;17962809;18037885;18065403;18220336;18378770;18438418;18477460;18521620;18566290;18615013;18669648;18691976;18694559;18801063;18843296;18991276;19004860;19043076;19081074;19106111;19164740;19332556;19339517;19369195;19564402;19591487;19638414;19656848;19664995;19690332;19801658;19805222;19940019;20038530;20041275;20048001;20056613;20068231;20230748;20308558;20399632;20407760;20531386;20545907;20558667;20637175;20679433;20696890;20699359;20798176;20805244;20819938;20966969;21036871;21063389;21084295;21097556;21145983;21258417;21273506;21347367;21422228;21422230;21478858;21532587;21548880;21565611;21620453;21689688;21725307;21792235;22013193;22072790;22094468;22157747;22168824;22179047;22190735;22195017;22299025;22365832;22424782;22433857;22641346;22653444;22675024;22916032;23106386;23141531;23141541;23186163;23253480;23348840;23378591;23400999;23439679;23479643;23481700;23482395;23530209;23636092;23698585;23747070;23769972;23789104;23864707;2388630;23921553;24053599;24089205;24119662;24231678;24424021;24469809;24550520;24715725;24917561;24982133;25047611;25202031;25313408;25406594;25492864;25525153;25532896;25586378;25619252;25645385;25969445;26154972;26237581;26929215;26992070;27600516;27920218;28063628;28228285;28467828;28649982;28832583;28834231;29242379;29314611;29331515;29393594;29557506;29632046;29632711;29769354;29784789;29786170;30315122;30429286;30484775;30524438;30779550;31154438;31530632;31844290;31848261;32157095;32265295;32357974;32387766;32488085;32897882;32938616;32983136;33298915;33392160;33402344;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34357683;34405274;34509645;34561969;34932366;35051231;35154160;35580925;36010968;36241641;36284347;36641675;37208565;37688771;38665916;7769006;7790358;8221884;8620540;8663406;8786104;8838651;9094723;9150144;9177194;9307973;9482744;9632646;9647643;9761932",
        "class_list": "",
        "function": "CSNK1D-mediated phosphorylation of HNRNPA2B1 induces miR-25-3p/miR-93-5p maturation to promote prostate cancer cell proliferation and migration through m[6]A-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]; Casein Kinase 1delta Phosphorylates TDP-43 and Suppresses Its Function in Tau mRNA Processing., [RefSeq, PubMed]; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Prognostic value and immunological role of CSNK1D in human cancers., [RefSeq, PubMed]; This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 23,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 7,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2I2P2;Q96KZ6;Q9BTN5",
        "ec_number_list": "3.6.5.-;2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.3.1.-;2.3.1.48;2.7.11.25;2.7.10.2;2.1.1.-;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;3.6.4.10;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;4.2.99.18;3.1.3.16;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;3.4.14.1;2.7.11.31;3.6.5.2;3.1.3.53;2.1.1.364;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;3.4.18.1;3.1.-.-;2.7.1.150",
        "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0045296 cadherin binding;GO:0050321 tau-protein kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome",
        "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0048208 COPII vesicle coating;GO:0016055 Wnt signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 28.7,
        "record_id": "P48730-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6Y2X3-1",
        "uniprot_id": "DJC14_HUMAN",
        "mass": 78569.0,
        "length": 702,
        "protein_name": "DnaJ homolog subfamily C member 14",
        "gene_name": "DNAJC14",
        "organism": "Human",
        "refseq_name": "dnaJ homolog subfamily C member 14 isoform 1",
        "refseq_ac": "NP_115740",
        "gene_names_uniprotkb": "DNAJC14; DRIP78; HDJ3",
        "gene_names_refseq": "DNAJC14; DNAJ; DRIP78; HDJ3; LIP6",
        "protein_names_uniprotkb": "DnaJ homolog subfamily C member 14; DRIP78; DnaJ protein homolog 3; Dopamine receptor-interacting protein of 78 kDa; Human DnaJ protein 3; hDj-3",
        "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 14; LYST-interacting protein LIP6; dnaJ homolog subfamily C member 14 isoform 1; dnaJ homolog subfamily C member 14; dnaJ protein homolog 3; dopamine receptor interacting protein; dopamine receptor-interacting protein of 78 kDa; human DnaJ protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:85406)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "11237011;11331877;12768437;22915803;23481700;25502872;26739057;26992070;27109633;28904123;29351928;29437277;29557506;31844290;32938616;39894887",
        "class_list": "",
        "function": "Hsc70 and DNAJC14 are required for the unconventional trafficking of H723R-pendrin. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface., [UniProtKB]; These findings support a novel model of DNAJC14 action that includes specific membrane targeting of both DNAJC14 and yellow fever virus replication proteins., [RefSeq, PubMed]; This suggests that DNAJC14's folding activity normally modulates yellow fever virus NS3/4A/2K cleavage events to liberate appropriate levels of NS3 and NS4A and promote replication complex formation. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5YM67;Q17RY2;Q66K17;Q96N59;Q96T63",
        "ec_number_list": "",
        "go_molecular_function": "GO:0050780 dopamine receptor binding",
        "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0015031 protein transport",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q6Y2X3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60568-1",
        "uniprot_id": "PLOD3_HUMAN",
        "mass": 84785.0,
        "length": 738,
        "protein_name": "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3",
        "gene_name": "PLOD3",
        "organism": "Human",
        "refseq_name": "multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 precursor",
        "refseq_ac": "NP_001075",
        "gene_names_uniprotkb": "PLOD3",
        "gene_names_refseq": "BCARD; LH3; PLOD3",
        "protein_names_uniprotkb": "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3; Galactosylhydroxylysine-glucosyltransferase; LH3; Lysyl hydroxylase 3; Procollagen galactosyltransferase; Procollagen glucosyltransferase",
        "protein_names_refseq": "lysine hydroxylase 3; lysyl hydroxlase 3; lysyl hydroxylase 3; multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 precursor; multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3",
        "tax_id": 9606,
        "disease": "BCARD syndrome (Disease Ontology:DOID:0061197); hypothyroidism (Disease Ontology:DOID:1459); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:8985);  (R-HSA-1650814)",
        "pathway_count": 2,
        "publication_count": 123,
        "publication_id_list": "37268159;10.1007/s00018-021-03863-1;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10479448;10686427;10934207;11237011;11896059;11956192;12473679;12475640;12646579;1323838;14500733;15044469;1577494;16591531;18298658;18487197;18834968;19075007;19693541;20470363;21465473;21878990;21967573;23090970;24190977;24397554;25418920;25419660;2543975;25576301;25645385;25813380;25892735;26154972;26992070;27600516;27846572;27920218;28218747;28467828;28834231;28904123;29242379;29314611;29317506;29393594;29437277;29493099;29557506;29632046;29632711;29741879;29769354;29786170;30089812;30237576;30315122;30410026;30573663;31154438;31222486;3173483;31844290;31848261;32157095;32161166;32350084;32488085;32897882;32938616;32983136;33043033;33214551;33298915;33392160;33465208;33592498;33633747;33717175;33912179;33936100;34019948;34089345;34171305;34185709;34357683;34561969;34576068;34646265;34725712;35008409;35039611;35051231;35138101;35154160;35251023;35254053;35318648;35580925;36010968;36241641;36284347;36403858;36581221;37074911;37938771;38184566;38665916;3905801;3938630;40596516;6307276;6809411;710450;9054364;9545296;9560306;9582318;9724729",
        "class_list": "glycogene;glycosyltransferase",
        "function": "A Human Pan-Cancer System Analysis of Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3). Publication Status: Online-Only, [RefSeq, PubMed]; Integrated Profiling Identifies PLOD3 as a Potential Prognostic and Immunotherapy Relevant Biomarker in Colorectal Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Lysyl hydroxylase 3-mediated post-translational modifications are required for proper biosynthesis of collagen alpha1alpha1alpha2(IV)., [RefSeq, PubMed]; Multifunctional enzyme that catalyzes a series of essential post-translational modifications on Lys residues in procollagen (PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812). Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812, PubMed:9582318, PubMed:9724729). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:10934207, PubMed:11896059, PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812). Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:25419660). Essential for normal biosynthesis and secretion of type IV collagens (Probable) (PubMed:18834968). Essential for normal formation of basement membranes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; PLOD3 facilitated T cell activation in the colorectal tumor microenvironment and liver metastasis by the TNF-alpha/ NF-kappaB pathway. Publication Status: Online-Only, [RefSeq, PubMed]; PLOD3 regulates the expression of YAP1 to affect the progression of non-small cell lung cancer via the PKCdelta/CDK1/LIMD1 signaling pathway., [RefSeq, PubMed]; The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 1051,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 47,
        "disease_count": 3,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6W6;Q540C3",
        "ec_number_list": "1.14.11.4;2.4.1.50;2.4.1.66",
        "go_molecular_function": "GO:0005506 iron ion binding;GO:0046872 metal ion binding;GO:0031418 L-ascorbic acid binding;GO:0036094 small molecule binding;GO:0008475 procollagen-lysine 5-dioxygenase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005791 rough endoplasmic reticulum;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0030199 collagen fibril organization;GO:0032964 collagen biosynthetic process;GO:0046947 hydroxylysine biosynthetic process;GO:0180062 protein O-linked glycosylation via galactose",
        "synthesized_glycan_count": 0,
        "hit_score": 17.7,
        "record_id": "O60568-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q05193-1",
        "uniprot_id": "DYN1_HUMAN",
        "mass": 97408.0,
        "length": 864,
        "protein_name": "Dynamin-1",
        "gene_name": "DNM1",
        "organism": "Human",
        "refseq_name": "dynamin-1 isoform 2",
        "refseq_ac": "NP_001005336",
        "gene_names_uniprotkb": "DNM1; DNM",
        "gene_names_refseq": "DEE31A; DEE31B; DEE31; DNM1; DNM; EIEE31",
        "protein_names_uniprotkb": "Dynamin-1; 3.6.5.5; Dynamin I; Dynamin",
        "protein_names_refseq": "dynamin I; dynamin-1 isoform 2",
        "tax_id": 9606,
        "disease": "developmental and epileptic encephalopathy 31B (Disease Ontology:DOID:0070376); developmental and epileptic encephalopathy 31A (Disease Ontology:DOID:0080437); Alzheimer's disease (Disease Ontology:DOID:10652); adult respiratory distress syndrome (Disease Ontology:DOID:11394); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); cystic fibrosis (Disease Ontology:DOID:1485); generalized epilepsy (Disease Ontology:DOID:1827); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung adenocarcinoma (Disease Ontology:DOID:3910); collagen disease (Disease Ontology:DOID:854); vasculitis (Disease Ontology:DOID:865)",
        "pathway": " (hsa:1759);  (R-HSA-166016);  (R-HSA-177504);  (R-HSA-190873);  (R-HSA-196025);  (R-HSA-2132295);  (R-HSA-3928665);  (R-HSA-437239);  (R-HSA-8856828)",
        "pathway_count": 9,
        "publication_count": 306,
        "publication_id_list": "10036229;10064083;10072072;10074457;10201950;10480952;10535736;10540230;10542231;10559856;10559861;10559924;10593899;10608864;10625686;10631941;10631952;10639150;10747093;10748235;10766777;10766823;10804209;10809954;10818153;11082044;11157096;11231140;11237011;11239472;11274165;11448999;11470803;11516654;11517213;11529500;11532990;11577110;11684289;11790530;11813165;11853874;11877457;11877461;11889126;12011079;12057195;12078484;12082080;12198492;12198549;12213833;12447393;12471095;12742663;12748383;12791276;12847086;12855954;12942088;12952949;12973357;14555962;14556004;14581451;14617351;14622578;14622579;14731593;15252009;15260957;15276183;15287745;15318165;15339664;15351694;15502812;15502813;15596121;15649145;15703209;15749704;15802264;15848800;15895077;15911768;15916959;16103228;16181339;16215232;16242130;16303959;16326391;16330023;16410077;16467847;16511561;16516836;16618111;16707488;16751103;16757566;16798879;16824007;16880396;16903783;17018281;17035995;17081983;17108328;17142755;17158794;17257598;17283181;17376771;17428795;17494869;17512409;17540576;17609109;17681954;17762867;17765681;17978091;18046453;18088087;18093523;18222170;18233961;18292509;18297073;18353773;18388313;18478542;1847920;18491316;18713744;18790740;18981233;19084269;19092055;19278660;19287005;19296720;19458185;19536138;1956401;19564404;19575674;19603039;19651622;19696796;19713939;19776351;19809571;20033059;20059951;20211604;20231386;20428113;20448150;20496116;20826345;20946875;21116285;2115402;21187331;21195118;2121367;21278753;21316588;21441454;21445324;21482805;21499258;21613550;21779028;21841790;21883765;2190094;21927000;21927001;21962517;22078883;22099461;22158869;22233676;22484487;22505844;22815487;22857010;22863004;23297414;23325789;23536704;23823722;23861397;23891661;23908769;2391366;24130457;24186068;2448316;24581490;2462607;2477488;24789820;24966051;25107275;25262651;25303366;25341920;25533962;25825441;26042225;26154972;26375851;26403691;26612256;27476654;27600516;27862975;28832583;29242379;29508533;29557506;29668686;29786170;30069048;30379171;30429286;30779550;30833945;31154438;31844290;31848261;31998317;32157095;32161166;32350084;32387766;32938616;33392160;33592498;33912179;33936100;33968037;33981976;34171305;34172529;34509645;34518553;34725712;35051231;3537192;35580925;36010968;36413998;6146630;7481823;7493978;7592972;7634088;7650016;7667286;7850421;7877694;7954789;8046351;8101525;8134367;8145819;8148318;8313912;8397411;8415765;8524399;8552632;8642258;8687433;8849454;8909537;8910402;8939989;8947036;9075930;9092476;9100026;9202021;9311912;9312039;9362482;9427626;9428629;9497313;9539769;9545226;9606180;9635431;9651214;9665271;9721721;9736607;9765310;9880482;9922133",
        "class_list": "",
        "function": "A recurrent de novo splice site variant involving DNM1 exon 10a causes developmental and epileptic encephalopathy through a dominant-negative mechanism., [RefSeq, PubMed]; Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE) (PubMed:15703209, PubMed:20428113, PubMed:29668686, PubMed:8101525, PubMed:8910402, PubMed:9362482). Associates to the membrane, through lipid binding, and self-assembles into rings and stacks of interconnected rings through oligomerization to form a helical polymer around the vesicle membrane leading to constriction of invaginated coated pits around their necks (PubMed:30069048, PubMed:7877694, PubMed:9922133). Self-assembly of the helical polymer induces membrane tubules narrowing until the polymer reaches a length sufficient to trigger GTP hydrolysis (PubMed:19084269). Depending on the curvature imposed on the tubules, membrane detachment from the helical polymer upon GTP hydrolysis can cause spontaneous hemifission followed by complete fission (PubMed:19084269). May play a role in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through its activation by dephosphorylation via the signaling downstream of EGFR (PubMed:29668686). Controls vesicle size at a step before fission, during formation of membrane pits, at hippocampal synapses (By similarity). Controls plastic adaptation of the synaptic vesicle recycling machinery to high levels of activity (By similarity). Mediates rapid endocytosis (RE), a Ca(2+)-dependent and clathrin- and K(+)-independent process in chromaffin cells (By similarity). Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP (By similarity). Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation (PubMed:12791276)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; CryoEM structure of the super-constricted two-start dynamin 1 filament. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 22,
        "reported_mutagensis": 19,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 12,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NLM6;Q5SYX0;Q5SYX2;Q6P3T6;Q86VD2",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;2.7.11.1;3.1.3.-;3.6.1.5;2.7.10.1;3.6.4.10;5.6.1.6;3.1.4.11;2.3.2.27;3.6.1.-;3.6.4.-;3.6.5.4;3.1.3.86;3.1.3.56;3.1.3.36;3.6.-.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0045202 synapse",
        "go_biological_process": "GO:0006897 endocytosis;GO:0051260 protein homooligomerization;GO:0051289 protein homotetramerization;GO:0007032 endosome organization;GO:0006898 receptor-mediated endocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 30.9,
        "record_id": "Q05193-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P43246-1",
        "uniprot_id": "MSH2_HUMAN",
        "mass": 104743.0,
        "length": 934,
        "protein_name": "DNA mismatch repair protein Msh2",
        "gene_name": "MSH2",
        "organism": "Human",
        "refseq_name": "DNA mismatch repair protein Msh2 isoform 1",
        "refseq_ac": "NP_000242",
        "gene_names_uniprotkb": "MSH2",
        "gene_names_refseq": "COCA1; FCC1; HNPCC1; HNPCC; LCFS2; LYNCH1; MMRCS2; MSH-2; MSH2; hMSH2",
        "protein_names_uniprotkb": "DNA mismatch repair protein Msh2; MutS protein homolog 2; hMSH2",
        "protein_names_refseq": "DNA mismatch repair protein Msh2 isoform 1; DNA mismatch repair protein Msh2 transcript; MutS-like 2; mutS homolog 2, colon cancer, nonpolyposis type 1",
        "tax_id": 9606,
        "disease": "Muir-Torre syndrome (Disease Ontology:DOID:0050465); colitis (Disease Ontology:DOID:0060180); hereditary nonpolyposis colorectal cancer type 8 (Disease Ontology:DOID:0070270); Lynch syndrome 1 (Disease Ontology:DOID:0070271); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); colon cancer (Disease Ontology:DOID:219); transitional cell carcinoma (Disease Ontology:DOID:2671); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); osteosarcoma (Disease Ontology:DOID:3347); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Lynch syndrome (Disease Ontology:DOID:3883); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); primary ovarian insufficiency (Disease Ontology:DOID:5426); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256); mismatch repair cancer syndrome 2 (MONDO:MONDO:0030840)",
        "pathway": " (hsa:4436);  (R-HSA-5358565);  (R-HSA-5358606);  (R-HSA-5632927);  (R-HSA-5632928);  (R-HSA-5632968);  (R-HSA-6796648)",
        "pathway_count": 7,
        "publication_count": 281,
        "publication_id_list": "10.1101/2023.09.13.557529;10023327;10078208;10375096;10386556;10469597;10473346;10528862;10573010;10612836;10660545;10713887;10777691;10783165;10829038;10856833;10938287;10984493;11005803;11237011;11274057;11306449;11350971;11427529;11429708;11441019;11555625;11698410;11726306;11809679;11809771;11809883;11839723;11870161;11884592;11920458;11971958;11988847;12112654;12124176;12132870;12200596;12362047;12373605;12414623;12549480;12655564;12655568;12658575;12792735;14504054;14635101;14636568;14657349;14676842;15046096;15064730;15225546;15300854;15342696;15365995;15613555;15781865;15808853;15837969;15870828;15896463;15991316;15996210;16143102;16188885;16252083;16372347;16451135;16464020;16793375;16855289;16873062;17080293;17101317;17128465;17414604;17426132;17525332;17531815;17555131;17611581;17697703;17984070;18033691;18326858;18561205;18625694;18674656;18675275;18781619;18822302;18951462;19228687;19562805;19596235;19608861;20068231;20112406;20154325;20160730;20571119;20713735;20970388;21120944;21419771;21496642;21561855;21642682;21926548;21937421;22012619;22102614;22118461;22179786;22277660;22371642;22581703;22988298;23065663;23186163;23301498;23391514;23481700;23622243;23646949;23840062;24366607;24554720;24662513;24714562;24715725;24882211;25134804;25418920;25429106;25469497;25561469;25576301;25645385;25712099;25978431;26154972;26300262;26375851;26728094;26768311;26811146;26929215;26992070;27600516;27846572;27893789;27920218;28228285;2842325;28494185;28832583;28834231;28904123;29242379;29437277;29493099;29508533;29557506;29632711;3004351;30315122;30397120;30429286;30484775;30524438;30779550;30833945;31092671;31154438;31217245;31222486;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32522876;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34357683;34405274;34509645;34725712;34932366;35008409;35051231;35083852;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37642881;37657688;37914149;37919876;37938771;38870667;40914422;7604266;7713503;7726159;7874129;7923193;8036718;8128251;8252616;8261515;8505312;8566964;8690195;8700523;8769132;8782829;8797773;8805365;8872463;8942985;8993976;9048925;9063748;9087566;9099749;9240418;9259192;9294177;9298827;9311737;9419403;9428522;9430682;9469823;9559627;9564049;9621522;9677427;9718327;9777949;9788596;9822679;9822680;9882630;9889267",
        "class_list": "",
        "function": "Assessing the role of MSH2 and MSH6 gene expression deficiency in prostate cancer progression, a cross-sectional study., [RefSeq, PubMed]; Component of the post-replicative DNA mismatch repair system (MMR)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand (PubMed:26300262). ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; LINC01232 targeting miR-1250-3p/MSH2 axis attenuates mesangial cell proliferation and fibrosis in diabetic nephropathy., [RefSeq, PubMed]; Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma., [RefSeq, PubMed]; Rare single-nucleotide variants of MLH1 and MSH2 genes in patients with Lynch syndrome., [RefSeq, PubMed]; Role of MLH1 and MSH2 deficiency in the development of tumorigenesis and chemo-tolerance of cervical Carcinoma: Clinical implications., [RefSeq, PubMed]; This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 89,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 25,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E2Z2;O75488",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0008047 enzyme activator activity;GO:0042803 protein homodimerization activity",
        "go_cellular_component": "GO:0032301 MutSalpha complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016020 membrane;GO:0032302 MutSbeta complex",
        "go_biological_process": "GO:0006312 mitotic recombination;GO:0006281 DNA repair;GO:0043524 negative regulation of neuron apoptotic process;GO:0008584 male gonad development;GO:0006298 mismatch repair",
        "synthesized_glycan_count": 0,
        "hit_score": 28.8,
        "record_id": "P43246-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N7U6-1",
        "uniprot_id": "EFHB_HUMAN",
        "mass": 93802.0,
        "length": 833,
        "protein_name": "EF-hand domain-containing family member B",
        "gene_name": "EFHB",
        "organism": "Human",
        "refseq_name": "EF-hand domain-containing family member B isoform 2",
        "refseq_ac": "NP_001317617",
        "gene_names_uniprotkb": "EFHB; CFAP21",
        "gene_names_refseq": "CFAP21; EFHB",
        "protein_names_uniprotkb": "EF-hand domain-containing family member B; Cilia- and flagella-associated protein 21",
        "protein_names_refseq": "EF-hand domain-containing family member B isoform 2; EF-hand domain-containing family member B; cilia and flagella associated protein 21",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:151651)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11237011;30481768;32387766;34171305;35051231;36191189",
        "class_list": "",
        "function": "EFHB is a new store-operated Ca2+ entry regulator that modulates STIM1-SARAF interaction. GeneRIF: EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction, [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion and the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus (PubMed:30481768)., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6ND25;A8MPR3;Q6ZWK9;Q8IV58;Q96LQ6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0061891 calcium ion sensor activity",
        "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0070884 regulation of calcineurin-NFAT signaling cascade;GO:0006816 calcium ion transport;GO:0030317 flagellated sperm motility;GO:0032091 negative regulation of protein binding;GO:2001256 regulation of store-operated calcium entry",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q8N7U6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7RTS9-1",
        "uniprot_id": "DYM_HUMAN",
        "mass": 75935.0,
        "length": 669,
        "protein_name": "Dymeclin",
        "gene_name": "DYM",
        "organism": "Human",
        "refseq_name": "dymeclin isoform 1",
        "refseq_ac": "NP_060123",
        "gene_names_uniprotkb": "DYM",
        "gene_names_refseq": "DMC; DYM; SMC",
        "protein_names_uniprotkb": "Dymeclin; Dyggve-Melchior-Clausen syndrome protein",
        "protein_names_refseq": "dyggve-Melchior-Clausen syndrome protein; dymeclin isoform 1",
        "tax_id": 9606,
        "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Smith-McCort dysplasia 1 (Disease Ontology:DOID:0081270); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167); osteochondrodysplasia (Disease Ontology:DOID:2256)",
        "pathway": " (hsa:54808)",
        "pathway_count": 1,
        "publication_count": 74,
        "publication_id_list": "10.1038/emboj.2013.79;11237011;12491225;12554689;18996921;19005420;21280149;23481700;23584533;24300288;24715725;25255805;25418920;25505266;25576301;25652408;25892735;26154972;26375851;26992070;27600516;27846572;27862975;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29351928;29393594;29437277;29493099;29508533;29557506;29632711;29786170;30315122;30429286;30484775;30524438;31217245;31844290;32157095;32350084;32387766;32502341;32886330;32897882;32938616;32983136;33141586;33298915;33592498;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34509645;34932366;35051231;35318648;35561310;35580925;36241641;36284347;37074911",
        "class_list": "",
        "function": "A homozygous nonsense variant in DYM underlies Dyggve-Melchior-Clausen syndrome associated with ectodermal features., [RefSeq, PubMed]; Dymeclin is crucial for proper myelination and anterograde neuronal trafficking, two processes that are highly active during postnatal brain maturation., [RefSeq, PubMed]; Gene mutations in a novel, evolutionarily conserved gene are identified in both rare autosomal recessive osteochondrodysplasias (DMC and SMC)., [RefSeq, PubMed]; Mutations cause Dyggve-Melchior-Clausen syndrome.  Normal function may be in process of intracellular digestion of proteins., [RefSeq, PubMed]; Necessary for correct organization of Golgi apparatus. Involved in bone development., [UniProtKB, PubMed]; The clinical diagnosis was confirmed with molecular analysis of DYM with a known mutation at c.580C>T (p.R194X)., [RefSeq, PubMed]; This gene encodes a protein which regulates Golgi-associated secretory pathways that are essential to endochondral bone formation during early development. This gene is also believed to play a role in early brain development. This gene is widely expressed in embryos and is particularly abundant in chodrocytes and brain tissues. It encodes a peripheral membrane protein which shuttles between the cytosol and Golgi complex. Mutations in this gene are associated with two types of recessive osteochondrodysplasia: Dyggve-Melchior-Clausen (DMC) dysplasia and Smith-McCort (SMC) dysplasia. [provided by RefSeq, Jun 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 4,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5I8;B2RCF9;B4DKI7;Q3ZTS8;Q6P2P5;Q8N2M0;Q9BVE9;Q9NPU7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019899 enzyme binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0016020 membrane",
        "go_biological_process": "GO:0060348 bone development;GO:0007030 Golgi organization",
        "synthesized_glycan_count": 0,
        "hit_score": 8.6,
        "record_id": "Q7RTS9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IV61-1",
        "uniprot_id": "GRP3_HUMAN",
        "mass": 78332.0,
        "length": 690,
        "protein_name": "Ras guanyl-releasing protein 3",
        "gene_name": "RASGRP3",
        "organism": "Human",
        "refseq_name": "ras guanyl-releasing protein 3 isoform 1",
        "refseq_ac": "NP_001132960",
        "gene_names_uniprotkb": "RASGRP3; GRP3; KIAA0846",
        "gene_names_refseq": "GRP3; RASGRP3",
        "protein_names_uniprotkb": "Ras guanyl-releasing protein 3; Calcium and DAG-regulated guanine nucleotide exchange factor III; Guanine nucleotide exchange factor for Rap1",
        "protein_names_refseq": "CalDAG-GEFIII; RAS guanyl releasing protein 3 (calcium and DAG-regulated); calcium and DAG-regulated guanine nucleotide exchange factor III; calcium- and diacylglycerol-regulated guanine nucleotide exchange factor III; guanine nucleotide exchange factor for Rap1; ras guanyl-releasing protein 3 isoform 1; ras guanyl-releasing protein 3",
        "tax_id": 9606,
        "disease": "hypertension (Disease Ontology:DOID:10763)",
        "pathway": " (hsa:25780);  (R-HSA-1169092);  (R-HSA-5673001)",
        "pathway_count": 3,
        "publication_count": 104,
        "publication_id_list": "10222061;10508167;10777492;10835426;10869344;10934204;11027663;11090077;11136978;11221888;11237011;11313946;11546808;11702783;12032311;12094235;12121613;12730099;14506247;14707138;15356145;1545823;15545601;15546878;15657177;16301621;16627759;16684964;1716764;17283063;17998941;18775330;1898771;19279408;19920141;20478380;21102635;21372320;21779497;21779505;21993244;22424782;22569528;22589270;22750304;23103841;23303910;23443682;23481700;23575685;23991094;24715725;24897931;24937142;25219551;25469497;25781681;25892735;26085527;26992070;27846572;27869121;27920218;28228285;28778966;28832583;28834231;28864115;28904123;28912101;29048643;29242379;29393594;29461644;29557506;29632046;30315122;30429286;30779550;31135801;31844290;32157095;32350084;32357974;32938616;33691108;33717175;33936100;34357683;34932366;35051231;36241641;6148751;7809086;7935463;7972015;8052307;8394845;8493579;8665852;8710374;8939933;9604935;9927426",
        "class_list": "",
        "function": "Guanine nucleotide exchange factor (GEF) for Ras and Rap1., [UniProtKB, PubMed]; In conclusion, these findings provide a new insight into the upregulation of RasGRP3 involved in Notch pathway activation in the development of esophageal squamous cell carcinoma , especially under nutrient deprivation., [RefSeq, PubMed]; RasGRP3, a Ras guanyl releasing protein 3 that contributes to malignant proliferation and aggressiveness in human esophageal squamous cell carcinoma, [RefSeq, PubMed]; The marked differences between RasGRP3 and RasGRP1 in membrane interaction necessarily will contribute to their different behavior in cells., [RefSeq, PubMed]; The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017]., [RefSeq]; These data show that RasGRP3 exerts its oncogenic effect in papillary thyroid cancer through Akt-mediated MDM2 activation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D6W583;O94931;Q53SD7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0019900 kinase binding;GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0032045 guanyl-nucleotide exchange factor complex",
        "go_biological_process": "GO:0000165 MAPK cascade;GO:0007265 Ras protein signal transduction;GO:0007264 small GTPase-mediated signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 10.5,
        "record_id": "Q8IV61-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14183-1",
        "uniprot_id": "DOC2A_HUMAN",
        "mass": 43959.0,
        "length": 400,
        "protein_name": "Double C2-like domain-containing protein alpha",
        "gene_name": "DOC2A",
        "organism": "Human",
        "refseq_name": "double C2-like domain-containing protein alpha",
        "refseq_ac": "NP_001268991",
        "gene_names_uniprotkb": "DOC2A",
        "gene_names_refseq": "DOC2A; Doc2",
        "protein_names_uniprotkb": "Double C2-like domain-containing protein alpha; Doc2-alpha; Doc2",
        "protein_names_refseq": "doc2-alpha; double C2-like domain-containing protein alpha; double C2-like domains, alpha",
        "tax_id": 9606,
        "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)",
        "pathway": " (hsa:8448)",
        "pathway_count": 1,
        "publication_count": 22,
        "publication_id_list": "11237011;18354201;23783831;25576301;27869121;28228285;28539418;28832583;29331515;29557506;30315122;30844661;31092671;31154438;31844290;32161166;33592498;33981976;7826360;8554557;9736751;9804756",
        "class_list": "",
        "function": "Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells., [UniProtKB, PubMed, PubMed, PubMed]; There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]., [RefSeq]; This study demonstrated that the DOCA2 increase expression in temporal lobe in temporal lobe epilepsy., [RefSeq, PubMed]; This study, members of the Doc2 family of presynaptic proteins were eliminated, which caused a reduction in spontaneous neurotransmission, whereas action potential-evoked neurotransmission remained relatively normal., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DEJ2;H3BNH6;Q6P4G4;Q7Z5G0;Q8IVX0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0045202 synapse;GO:0005764 lysosome;GO:0043005 neuron projection",
        "go_biological_process": "GO:0007399 nervous system development;GO:0007268 chemical synaptic transmission;GO:0045956 positive regulation of calcium ion-dependent exocytosis;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:0099502 calcium-dependent activation of synaptic vesicle fusion",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q14183-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NYC9-1",
        "uniprot_id": "DYH9_HUMAN",
        "mass": 511877.0,
        "length": 4486,
        "protein_name": "Dynein axonemal heavy chain 9",
        "gene_name": "DNAH9",
        "organism": "Human",
        "refseq_name": "dynein axonemal heavy chain 9 isoform 2",
        "refseq_ac": "NP_001363",
        "gene_names_uniprotkb": "DNAH9; DNAH17L; DNEL1; KIAA0357",
        "gene_names_refseq": "CILD40; DNAH17L; DNAH9; DNEL1; DYH9; Dnahc9; HL-20; HL20",
        "protein_names_uniprotkb": "Dynein axonemal heavy chain 9; Axonemal beta dynein heavy chain 9; Ciliary dynein heavy chain 9",
        "protein_names_refseq": "DNAH9 variant protein; axonemal beta dynein heavy chain 9; ciliary dynein heavy chain 9; dynein axonemal heavy chain 9 isoform 2; dynein, axonemal, heavy polypeptide 9",
        "tax_id": 9606,
        "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); episodic ataxia type 1 (Disease Ontology:DOID:0050989); primary ciliary dyskinesia 40 (Disease Ontology:DOID:0111853); sensorineural hearing loss (Disease Ontology:DOID:10003); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); epilepsy (Disease Ontology:DOID:1826); pulmonary hypertension (Disease Ontology:DOID:6432)",
        "pathway": " (hsa:1770)",
        "pathway_count": 1,
        "publication_count": 47,
        "publication_id_list": "11104725;11237011;11247663;14978097;16959974;18452278;20068231;23481700;24715725;26768311;27846572;27920218;28218747;28832583;28904123;29242379;29393594;29557506;29786170;30315122;30379171;30471717;30471718;31092671;31178125;31217245;31222486;31324691;31530632;31844290;32157095;32357974;32387766;32938616;33968037;34008076;34087483;34211107;34405274;34561969;35050399;35051231;35318648;36140829;36215666;37217939;37486510",
        "class_list": "",
        "function": "Biallelic DNAH9 mutations are identified in Chinese patients with defective left-right patterning and cilia-related complex congenital heart disease., [RefSeq, PubMed]; Clustering of Genetic Anomalies of Cilia Outer Dynein Arm and Central Apparatus in Patients with Transposition of the Great Arteries. Publication Status: Online-Only, [RefSeq, PubMed]; Force generating protein required for cilia beating in respiratory epithelia (PubMed:30471717, PubMed:30471718). Produces force towards the minus ends of microtubules (PubMed:30471717, PubMed:30471718). Key component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (PubMed:30471717, PubMed:30471718). Required for structural and functional integrity of cilia (PubMed:30471717, PubMed:30471718)., [UniProtKB, PubMed, PubMed, UniProtKB]; Force generating protein required for cilia beating in respiratory epithelia. Produces force towards the minus ends of microtubules. Key component of dynein, a family of motor proteins essential for movement along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of cilia., [UniProtKB, UniProtKB]; Meta-analysis of Transcriptomic Data from Lung Autopsy and Cellular Models of SARS-CoV-2 Infection., [RefSeq, PubMed]; This gene encodes the heavy chain subunit of axonemal dynein, a large multi-subunit molecular motor. Axonemal dynein attaches to microtubules and hydrolyzes ATP to mediate the movement of cilia and flagella. The gene expresses at least two transcript variants; additional variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]; Whole-exome sequencing reveals a combination of extremely rare single-nucleotide polymorphism of DNAH9 and RSPH1 genes in a Japanese fetus with situs viscerum inversus., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 141,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2VCQ8;O15064;O95494;Q9NQ28",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding",
        "go_cellular_component": "GO:0097229 sperm end piece;GO:0005874 microtubule;GO:0031514 motile cilium;GO:0036126 sperm flagellum;GO:0005814 centriole",
        "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0030030 cell projection organization;GO:0003341 cilium movement;GO:0007018 microtubule-based movement",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "Q9NYC9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y2X8-1",
        "uniprot_id": "UB2D4_HUMAN",
        "mass": 16649.0,
        "length": 147,
        "protein_name": "Ubiquitin-conjugating enzyme E2 D4",
        "gene_name": "UBE2D4",
        "organism": "Human",
        "refseq_name": "ubiquitin-conjugating enzyme E2 D4",
        "refseq_ac": "NP_057067",
        "gene_names_uniprotkb": "UBE2D4; UBCH5D",
        "gene_names_refseq": "HBUCE1; UBE2D4",
        "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 D4; 2.3.2.23; E2 ubiquitin-conjugating enzyme D4; HBUCE1; Ubiquitin carrier protein D4; Ubiquitin-protein ligase D4",
        "protein_names_refseq": "E2 ubiquitin-conjugating enzyme D4; ubiquitin carrier protein D4; ubiquitin conjugating enzyme E2 D4 (putative); ubiquitin conjugating enzyme E2D 4 (putative); ubiquitin-conjugating enzyme E2 D4; ubiquitin-conjugating enzyme HBUCE1; ubiquitin-protein ligase D4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51619);  (R-HSA-983168)",
        "pathway_count": 2,
        "publication_count": 39,
        "publication_id_list": "11062501;11237011;11350924;12646216;14734113;15224091;15224092;15571818;16595681;16849449;16954532;18446792;18662542;19028597;19352404;19452197;19489725;19851334;19874575;19940261;20061386;2261476;27920218;28218747;28228285;28832583;28834231;28904123;29242379;29331515;29437277;29508533;29632711;29786170;30315122;32502341;33141586;9380723;9668046",
        "class_list": "",
        "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D1V0",
        "ec_number_list": "6.2.1.45;2.3.2.24;2.3.2.23;2.3.2.26;2.3.2.27;2.3.2.31;2.3.2.-;6.2.1.-;2.3.2.34;2.3.2.32;3.6.4.-;6.2.1.64;2.3.2.25;2.3.2.36;2.7.11.1",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0016567 protein ubiquitination;GO:0070979 protein K11-linked ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination;GO:0070534 protein K63-linked ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q9Y2X8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P09110-1",
        "uniprot_id": "THIK_HUMAN",
        "mass": 44292.0,
        "length": 424,
        "protein_name": "3-ketoacyl-CoA thiolase, peroxisomal",
        "gene_name": "ACAA1",
        "organism": "Human",
        "refseq_name": "3-ketoacyl-CoA thiolase, peroxisomal isoform b",
        "refseq_ac": "NP_001123882",
        "gene_names_uniprotkb": "ACAA1; ACAA; PTHIO",
        "gene_names_refseq": "ACAA1; ACAA; Lnc-Myd88; PTHIO; THIO",
        "protein_names_uniprotkb": "3-ketoacyl-CoA thiolase, peroxisomal; 2.3.1.155; 2.3.1.16; 2.3.1.9; Acetyl-CoA C-myristoyltransferase; Acetyl-CoA acyltransferase; Beta-ketothiolase; Peroxisomal 3-oxoacyl-CoA thiolase",
        "protein_names_refseq": "3-ketoacyl-CoA thiolase, peroxisomal isoform b; 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA C-myristoyltransferase; acetyl-Coenzyme A acyltransferase 1; beta-ketothiolase; epididymis secretory sperm binding protein; peroxisomal 3-oxoacyl-CoA thiolase; peroxisomal 3-oxoacyl-Coenzyme A thiolase; testicular tissue protein Li 197",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:30);  (R-HSA-2046106);  (R-HSA-390247);  (R-HSA-6798695);  (R-HSA-9033241);  (R-HSA-9033500)",
        "pathway_count": 6,
        "publication_count": 134,
        "publication_id_list": "10.1101/2023.09.13.557529;10022913;10198260;10562279;10601301;10673331;10899997;10903473;11101887;11237011;11500517;11514237;11546814;11673457;11734571;11781871;11931631;11988075;12323085;12323090;12456682;12559034;12562861;12578380;12713571;12716664;12717447;12885776;12897190;1346092;14636670;15060085;15545321;15858711;16385454;1651711;16766224;1679347;16854980;16940157;17007944;17726030;1834642;18359941;18538142;18712838;19056654;19197237;19208625;19584060;19632994;19690332;20178365;21145416;21554508;21976670;21980954;22002062;22057399;22151743;22371489;22493507;22534643;22745130;22747494;23650620;23963456;24235149;24865970;25016021;25538232;25854684;26086376;26138649;26220973;26344566;26992070;2726492;27597759;28521612;28611990;28765278;28787099;2882519;28832583;29242379;29557506;30429286;30484775;31217245;31844290;3194209;32157095;32502341;32938616;33500543;33592498;33717175;33912179;33968037;34171305;34465723;35051231;35318648;35580925;35951481;36010968;36215666;36241641;36284347;37129951;38154980;486181;6798973;7061494;7685190;7719337;7790377;8096621;8656081;8692836;8824437;8832760;8858165;8902629;8991089;9089413;9090381;9090382;9090383;9539740;9653144;9668159;9837948",
        "class_list": "",
        "function": "A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-beta pathology and cognitive decline. Publication Status: Online-Only, [RefSeq, PubMed]; Findings suggest that protective effects of endotoxin exposure on asthma may vary depending upon the presence or absence of a polymorphism in ACAA1. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of ACAA1 Restrains Proliferation and Potentiates the Response to CDK4/6 Inhibitors in Triple-Negative Breast Cancer., [RefSeq, PubMed]; Responsible for the thiolytic cleavage of straight chain 3-keto fatty acyl-CoAs (3-oxoacyl-CoAs) (PubMed:11734571, PubMed:2882519). Plays an important role in fatty acid peroxisomal beta-oxidation (PubMed:11734571, PubMed:2882519). Catalyzes the cleavage of short, medium, long, and very long straight chain 3-oxoacyl-CoAs (PubMed:11734571, PubMed:2882519). May play a role in peroxisomal beta-oxidation step in polyunsaturated fatty acids (PUFAs) biosynthesis. Possibly regulates systemic levels of docosahexaenoic acid (DHA, C22:6n-3) through a process involving endoplasmic reticulum desaturation and elongation of alpha-linolenic acid (ALA, C18:3n-3) to form tetracosahexaenoic acid (THA, C24:6n-3), which is then beta-oxidized to DHA in peroxisomes., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]., [RefSeq]; [Clinical phenotypic and genotypic analysis of 5 pediatric patients with beta-ketothiolase deficiency]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 9803,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "G5E935;Q96CA6",
        "ec_number_list": "2.5.1.26;1.8.3.2;2.7.1.35;1.14.11.18;2.3.2.27;3.4.21.-;3.5.3.1;3.4.23.5;3.4.21.37;2.3.1.16;2.3.1.9;2.3.1.155;1.4.3.22;1.4.3.-;2.3.1.176;3.4.24.34;2.3.2.36;3.1.3.48;2.7.10.2;3.1.2.-;3.1.2.2;3.1.2.1;3.1.21.-;3.6.5.2;3.2.1.17;3.2.1.14;2.3.2.5;3.6.1.6;3.4.19.9;3.2.1.18;3.5.1.3;3.4.18.1;3.2.1.166",
        "go_molecular_function": "GO:0003988 acetyl-CoA C-acyltransferase activity;GO:0003985 acetyl-CoA C-acetyltransferase activity;GO:0008775 acetate CoA-transferase activity;GO:0050633 acetyl-CoA C-myristoyltransferase activity;GO:0120524 long-chain fatty acyl-CoA oxidase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0010124 phenylacetate catabolic process;GO:0000038 very long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase;GO:0036109 alpha-linolenic acid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 13.7,
        "record_id": "P09110-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86TI2-1",
        "uniprot_id": "DPP9_HUMAN",
        "mass": 98263.0,
        "length": 863,
        "protein_name": "Dipeptidyl peptidase 9",
        "gene_name": "DPP9",
        "organism": "Human",
        "refseq_name": "dipeptidyl peptidase 9 isoform 1",
        "refseq_ac": "NP_631898",
        "gene_names_uniprotkb": "DPP9; DPRP2",
        "gene_names_refseq": "DP9; DPLP9; DPP IX; DPP9; DPRP-2; DPRP2; HATIS; IMD111",
        "protein_names_uniprotkb": "Dipeptidyl peptidase 9; 3.4.14.5; DP9; DPLP9; DPP IX; DPRP-2; Dipeptidyl peptidase IV-related protein 2; Dipeptidyl peptidase IX; Dipeptidyl peptidase-like protein 9",
        "protein_names_refseq": "dipeptidyl peptidase 9 isoform 1; dipeptidyl peptidase IV-related protein-2; dipeptidyl peptidase IX; dipeptidyl peptidase-like protein 9",
        "tax_id": 9606,
        "disease": "primary immunodeficiency disease (Disease Ontology:DOID:612); hatipoglu immunodeficiency syndrome (MONDO:MONDO:0957229)",
        "pathway": " (hsa:91039)",
        "pathway_count": 1,
        "publication_count": 105,
        "publication_id_list": "11237011;12459266;12662155;15245913;16475979;19667070;21209280;22645359;23481700;24397554;24562348;24714562;25418920;25576301;25645385;26154972;26375851;26728094;26811146;26929215;26992070;27600516;27820798;27846572;27920218;28063628;28218747;28228285;28649982;28832583;28834231;28904123;29242379;29331515;29382749;29393594;29493099;29557506;29632046;29632711;29786170;29789417;29967349;30291141;30315122;30429286;30484775;30779550;30833945;31092671;31217245;31525884;31530632;31844290;31848261;31937595;32157095;32350084;32357974;32387766;32488085;32502341;32796818;32897882;32938616;32983136;33123756;33141586;33298915;33537174;33592498;33633747;33691108;33731929;33731932;33912179;33936100;33968037;33981976;34019797;34087483;34171305;34185709;34357683;34405274;34509645;34932366;35051231;35154160;35318648;35494241;35561310;35580925;36010968;36112693;36215666;36241641;36284347;36357533;37544411;37713596;37938771;38458339;38531482;39094401",
        "class_list": "",
        "function": "DPP8/9 inhibition attenuates the TGF-beta1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways., [RefSeq, PubMed]; DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma., [RefSeq, PubMed]; DPP9 regulates NQO1 and ROS to promote resistance to chemotherapy in liver cancer cells., [RefSeq, PubMed]; Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:29382749, PubMed:30291141, PubMed:33731929, PubMed:36112693). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:30291141, PubMed:31525884, PubMed:32796818, PubMed:36112693, PubMed:36357533). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:33731929, PubMed:33731932, PubMed:34019797). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (PubMed:33731929)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and metastasis in breast cancer., [RefSeq, PubMed]; Hemophagocytic lymphohistiocytosis-like hyperinflammation due to a de novo mutation in DPP9. Erratum:[J Allergy Clin Immunol. 2025 Oct;156(4):1124. doi: 10.1016/j.jaci.2025.08.002. PMID: 40864024], [RefSeq, PubMed]; Identification of two forms, their tissue distribution, cytoplasmic localization, [RefSeq, PubMed]; This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75273;O75868;Q1ZZB8;Q6AI37;Q6UAL0;Q6ZMT2;Q6ZNJ5;Q8N2J7;Q8N3F5;Q8WXD8;Q96NT8;Q9BVR3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0042802 identical protein binding;GO:0004177 aminopeptidase activity;GO:0008236 serine-type peptidase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005874 microtubule;GO:0031252 cell leading edge",
        "go_biological_process": "GO:0006508 proteolysis;GO:0043069 negative regulation of programmed cell death;GO:0070269 pyroptotic inflammatory response",
        "synthesized_glycan_count": 0,
        "hit_score": 10.6,
        "record_id": "Q86TI2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NUI1-1",
        "uniprot_id": "DECR2_HUMAN",
        "mass": 30778.0,
        "length": 292,
        "protein_name": "Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]",
        "gene_name": "DECR2",
        "organism": "Human",
        "refseq_name": "peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]",
        "refseq_ac": "NP_065715",
        "gene_names_uniprotkb": "DECR2; PDCR; SDR17C1",
        "gene_names_refseq": "DECR2; PDCR; SDR17C1",
        "protein_names_uniprotkb": "Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]; 1.3.1.124; 2,4-dienoyl-CoA reductase 2; Short chain dehydrogenase/reductase family 17C member 1; pDCR",
        "protein_names_refseq": "2,4-dienoyl-CoA reductase 2, peroxisomal; peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]; peroxisomal 2,4-dienoyl-CoA reductase; short chain dehydrogenase/reductase family 17C member 1",
        "tax_id": 9606,
        "disease": "ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841)",
        "pathway": " (hsa:26063);  (R-HSA-390247);  (R-HSA-9033241)",
        "pathway_count": 3,
        "publication_count": 107,
        "publication_id_list": "10.1101/2023.09.13.557529;10022913;10198260;10562279;10673331;11101887;11237011;11514237;11546814;11673457;11781871;11931631;12456682;12559034;12578380;12717447;12885776;15060085;15545321;15858711;16385454;1651711;1679347;16854980;16940157;17007944;17081983;17726030;18359941;18712838;19197237;19208625;19584060;19608861;19632994;20068231;20178365;21145416;21554508;21976670;21980954;22002062;22057399;22371489;22493507;22534643;22745130;22747494;23186163;23481700;23963456;24235149;24366607;24865970;25016021;25538232;25576301;25854684;26086376;26138649;26220973;26344566;27597759;27920218;28510447;28521612;28611990;28765278;28787099;28832583;28834231;29242379;29393594;29557506;30315122;31217245;31844290;31848261;32938616;33500543;33592498;33691108;33717175;33912179;33968037;35051231;35561310;36241641;38216720;38253038;40596516;486181;6798973;7719337;7790377;8824437;8858165;8902629;8991089;9089413;9090381;9090382;9090383;9539740;9653144;9668159;9837948",
        "class_list": "",
        "function": "Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Peroxisomal beta-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ZRS7;Q96ET0",
        "ec_number_list": "3.6.1.-;3.6.1.77;3.1.2.2;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;2.3.1.42;1.3.3.6;2.3.2.27;1.1.1.42;1.11.1.6;3.4.24.56;1.4.3.3;2.6.1.51;2.6.1.44;2.3.1.176;2.3.1.16;2.3.1.155;2.3.2.36;1.14.13.39;4.1.3.4;2.3.1.137;2.3.1.7;5.3.3.21;2.3.1.65;1.3.1.124;3.4.21.-;1.5.3.13;3.4.21.53;1.4.3.1;1.1.1.184;1.3.1.38;1.1.3.15;1.5.3.1;1.5.3.7;5.1.99.4;4.1.2.63;1.2.3.5;2.5.1.18",
        "go_molecular_function": "GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity;GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity",
        "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005829 cytosol",
        "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0009062 fatty acid catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 11.3,
        "record_id": "Q9NUI1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NX09-1",
        "uniprot_id": "DDIT4_HUMAN",
        "mass": 25371.0,
        "length": 232,
        "protein_name": "DNA damage-inducible transcript 4 protein",
        "gene_name": "DDIT4",
        "organism": "Human",
        "refseq_name": "DNA damage-inducible transcript 4 protein",
        "refseq_ac": "NP_061931",
        "gene_names_uniprotkb": "DDIT4; REDD1; RTP801",
        "gene_names_refseq": "DDIT4; Dig2; REDD-1; REDD1",
        "protein_names_uniprotkb": "DNA damage-inducible transcript 4 protein; HIF-1 responsive protein RTP801; Protein regulated in development and DNA damage response 1; REDD-1",
        "protein_names_refseq": "DNA damage-inducible transcript 4 protein; HIF-1 responsive protein RTP801; protein regulated in development and DNA damage response 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54541);  (R-HSA-5628897)",
        "pathway_count": 2,
        "publication_count": 152,
        "publication_id_list": "10329961;10716435;10745013;10980602;11029283;11034341;11230166;11237011;11340051;11486029;11545734;11884613;11959846;12161445;12203114;12438239;12453409;12714747;12869586;12906785;13298683;13538944;14646594;14651849;15105503;15180327;15223;15545625;15589136;15592522;15632201;15751966;15988001;16140933;16413492;16636147;16728594;16760263;16839880;17005863;17298220;17379067;17486094;17540029;18198340;18344994;18692468;19113821;19439913;19487573;19557001;19822145;20080666;20112406;20166753;20182617;20351271;20378837;21460850;21750704;21958598;22363791;22424782;22898188;23717519;23775793;24066844;24366874;24383451;24714562;24715725;24718924;25418920;25576301;25579166;26154972;26375851;26652033;26811146;26992070;27600516;27846572;27920218;28063628;28218747;28228285;28514659;28832583;28904123;29093164;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29786170;29789417;30315122;30410026;30429286;30524438;30779550;30784271;30833945;31154438;31217245;31222486;31844290;31848261;31937595;31998317;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33537174;33592498;33691108;33717175;33968037;33981976;34171305;34405274;34509645;34932366;35051231;35318648;35580925;36010968;36215666;36241641;37483165;37938616;37938771;38507057;38546584;39268577;5666113;7979252;7989588;8119488;9926927",
        "class_list": "",
        "function": "Co-transfection with antisense Sp1 oligonucleotide suggests that hypoxia induction of the RTP801 promoter is mediated by Sp1, [RefSeq, PubMed]; NLRP3 Inflammasome Priming in the Retina of Diabetic Mice Requires REDD1-Dependent Activation of GSK3beta., [RefSeq, PubMed]; Nuclear overexpression of DNA damage-inducible transcript 4 (DDIT4) is associated with aggressive tumor behavior in patients with pancreatic tumors. Publication Status: Online-Only, [RefSeq, PubMed]; Pan-cancer analysis of DDIT4 identifying its prognostic value and function in acute myeloid leukemia. Publication Status: Online-Only, [RefSeq, PubMed]; REDD1 (regulated in development and DNA damage 1) modulates the glucocorticoid receptor function in keratinocytes., [RefSeq, PubMed]; RTP801 interacts with the tRNA ligase complex and dysregulates its RNA ligase activity in Alzheimer's disease., [RefSeq, PubMed]; RTP801 might play important roles in Abeta toxicity and the pathogenesis of Alzheimer's disease, [RefSeq, PubMed]; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9H0S3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0071889 14-3-3 protein binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0051607 defense response to virus;GO:0001666 response to hypoxia;GO:0001764 neuron migration;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 15.3,
        "record_id": "Q9NX09-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UHG0-1",
        "uniprot_id": "DCDC2_HUMAN",
        "mass": 52834.0,
        "length": 476,
        "protein_name": "Doublecortin domain-containing protein 2",
        "gene_name": "DCDC2",
        "organism": "Human",
        "refseq_name": "doublecortin domain-containing protein 2",
        "refseq_ac": "NP_001182539",
        "gene_names_uniprotkb": "DCDC2; KIAA1154; RU2",
        "gene_names_refseq": "DCDC2A; DCDC2; DFNB66; NPHP19; NSC; RU2S; RU2",
        "protein_names_uniprotkb": "Doublecortin domain-containing protein 2; Protein RU2S",
        "protein_names_refseq": "doublecortin domain-containing protein 2; nephronophthisis 19",
        "tax_id": 9606,
        "disease": "autosomal recessive nonsyndromic deafness 66 (Disease Ontology:DOID:0110517); nephronophthisis 19 (Disease Ontology:DOID:0111126); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); sclerosing cholangitis (Disease Ontology:DOID:14268); dyslexia (Disease Ontology:DOID:4428); isolated neonatal sclerosing cholangitis (MONDO:MONDO:0018816)",
        "pathway": " (hsa:51473)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "10601354;11237011;16278297;16385449;19664994;21698230;25557784;25601850;27319779;27469900;29242379;29557506;29786170;31844290;33537174;34087483;36010968;36938759;38610086;38658618",
        "class_list": "",
        "function": "Biallelic known and novel DCDC2 variants in cholestatic liver disease: Phenotype-genotype observations in four children., [RefSeq, PubMed]; DCDC2 inhibits hepatic stellate cell activation and ameliorates CCl4-induced liver fibrosis by suppressing Wnt/beta-catenin signaling. Publication Status: Online-Only, [RefSeq, PubMed]; DCDC2 is proposed as a candidate gene for reading disability. Erratum:[Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18763], [RefSeq, PubMed]; DCDC2 overexpression in C. elegans causes an abnormal neuronal phenotype that can only be seen in ciliated neurons. Together our results suggest a potential role for DCDC2 in the structure and function of primary cilia, [RefSeq, PubMed]; Developmental dyslexia susceptibility genes DNAAF4, DCDC2, and NRSN1 are associated with brain function in fluently reading adolescents and young adults., [RefSeq, PubMed]; Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 6,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VTR8;Q5VTR9;Q86W35;Q9UFD1;Q9UHG1;Q9ULR6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019894 kinesin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005929 cilium;GO:0005815 microtubule organizing center;GO:0005930 axoneme",
        "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0035556 intracellular signal transduction;GO:0001764 neuron migration;GO:0006968 cellular defense response;GO:0060271 cilium assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q9UHG0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UI36-1",
        "uniprot_id": "DACH1_HUMAN",
        "mass": 78562.0,
        "length": 758,
        "protein_name": "Dachshund homolog 1",
        "gene_name": "DACH1",
        "organism": "Human",
        "refseq_name": "dachshund homolog 1 isoform c",
        "refseq_ac": "NP_004383",
        "gene_names_uniprotkb": "DACH1; DACH",
        "gene_names_refseq": "DACH1; DACH",
        "protein_names_uniprotkb": "Dachshund homolog 1; Dach1",
        "protein_names_refseq": "dac homolog; dachshund homolog 1 isoform c; dachshund homolog 1",
        "tax_id": 9606,
        "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); congenital nonspherocytic hemolytic anemia 9 (Disease Ontology:DOID:0051008); transient myeloproliferative syndrome (Disease Ontology:DOID:0060888); myeloid leukemia associated with Down Syndrome (Disease Ontology:DOID:0080798); X-linked thrombocytopenia with beta-thalassemia (Disease Ontology:DOID:0111767); X-linked dyserythropoietic anemia (Disease Ontology:DOID:0112156); beta thalassemia (Disease Ontology:DOID:12241); lung cancer (Disease Ontology:DOID:1324); major depressive disorder (Disease Ontology:DOID:1470); thrombocytopenia (Disease Ontology:DOID:1588); depressive disorder (Disease Ontology:DOID:1596); colon adenocarcinoma (Disease Ontology:DOID:234); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); myelofibrosis (Disease Ontology:DOID:4971); polycythemia (Disease Ontology:DOID:8432); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:1602)",
        "pathway_count": 1,
        "publication_count": 27,
        "publication_id_list": "10502110;11237011;11543628;12057194;14525983;25645385;26992070;27862975;28834231;31848261;32119511;32387766;32897882;33592498;33968037;34171305;34509645;34846842;35051231;35138101;35580925;36240223;36754276;37243970;38147289;38542074;9651501",
        "class_list": "",
        "function": "DACH1 attenuated PA-induced renal tubular injury through TLR4/MyD88/NF-kappaB and TGF-beta/Smad signalling pathway., [RefSeq, PubMed]; DACH1 regulates macrophage activation and tumour progression in hypopharyngeal squamous cell carcinoma., [RefSeq, PubMed]; Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity., [RefSeq, PubMed]; Dachshund Homolog 1: Unveiling Its Potential Role in Megakaryopoiesis and Bacillus anthracis Lethal Toxin-Induced Thrombocytopenia. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]., [RefSeq]; Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation also seems to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity)., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 17,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A087WZP2;D0FY35;D0FY36;O75523;O75687;Q5VYY3;Q5VYY4;Q96SG3;Q96SG4;Q9H524;Q9UMH4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex",
        "go_biological_process": "GO:0033262 regulation of nuclear cell cycle DNA replication;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030336 negative regulation of cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "Q9UI36-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UK59-1",
        "uniprot_id": "DBR1_HUMAN",
        "mass": 61555.0,
        "length": 544,
        "protein_name": "Lariat debranching enzyme",
        "gene_name": "DBR1",
        "organism": "Human",
        "refseq_name": "lariat debranching enzyme",
        "refseq_ac": "NP_057300",
        "gene_names_uniprotkb": "DBR1",
        "gene_names_refseq": "DBR1; XGIP",
        "protein_names_uniprotkb": "Lariat debranching enzyme; 3.1.4.-",
        "protein_names_refseq": "RNA lariat debranching enzyme; debranching enzyme homolog 1; lariat debranching enzyme",
        "tax_id": 9606,
        "disease": "brain disease (Disease Ontology:DOID:936); encephalitis, acute, infection (viral)-induced, susceptibility to, 11 (MONDO:MONDO:0030334); xerosis and growth failure with immune and pulmonary dysfunction syndrome (MONDO:MONDO:0957786)",
        "pathway": " (hsa:51163)",
        "pathway_count": 1,
        "publication_count": 77,
        "publication_id_list": "10982890;11237011;16232320;17081983;17322306;1850323;18669648;18691976;19608861;19651622;20068231;21406692;23186163;23301498;23481700;24275569;2435736;24672043;24715725;25418920;25505266;25576301;25645385;26154972;26768311;26811146;26992070;27600516;27846572;27920218;28063628;28218747;28228285;28510447;28904123;29242379;29393594;29437277;29474921;29493099;29557506;29632046;29786170;30315122;30379171;30429286;31154438;31844290;31998317;32157095;32161166;32265295;32387766;32897882;32938616;32983136;33298915;33392160;33537174;33592498;33691108;33912179;33968037;34087483;34405274;35051231;35318648;35561310;35580925;36215666;36241641;37656279;37800682;37938771;38665916;38816363;40914422",
        "class_list": "",
        "function": "A founder DBR1 variant causes a lethal form of congenital ichthyosis., [RefSeq, PubMed]; Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover (PubMed:10982890, PubMed:16232320, PubMed:2435736). Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis and have an antiviral cell-intrinsic defense function in the brainstem (PubMed:16232320, PubMed:29474921)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Dbr1 protein cleaves the 2'-5' phosphodiester bond of intron lariats, necessary for subsequent intron degradation that follows pre-mRNA splicing., [RefSeq, PubMed]; Inhibition of DBR1 caused a significant reduction in the formation of intermediate and full-length HIV-1 cDNA., [RefSeq, PubMed]; The debranching enzyme Dbr1 regulates lariat turnover and intron splicing. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication. [provided by RefSeq, Nov 2011]., [RefSeq]; Trichothiodystrophy-associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96GH0;Q9NXQ6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008419 RNA lariat debranching enzyme activity;GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0016787 hydrolase activity;GO:0016788 hydrolase activity, acting on ester bonds",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0000375 RNA splicing, via transesterification reactions;GO:0050821 protein stabilization;GO:0000398 mRNA splicing, via spliceosome;GO:0000292 RNA fragment catabolic process;GO:0006397 mRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 8.0,
        "record_id": "Q9UK59-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9ULE3-1",
        "uniprot_id": "DEN2A_HUMAN",
        "mass": 113853.0,
        "length": 1009,
        "protein_name": "DENN domain-containing protein 2A",
        "gene_name": "DENND2A",
        "organism": "Human",
        "refseq_name": "DENN domain-containing protein 2A isoform a",
        "refseq_ac": "NP_001304981",
        "gene_names_uniprotkb": "DENND2A; KIAA1277",
        "gene_names_refseq": "DENND2A; FAM31D; KIAA1277",
        "protein_names_uniprotkb": "DENN domain-containing protein 2A",
        "protein_names_refseq": "DENN domain-containing protein 2A isoform a; DENN domain-containing protein 2A; DENN/MADD domain containing 2A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:27147);  (R-HSA-8876198)",
        "pathway_count": 2,
        "publication_count": 208,
        "publication_id_list": "10818110;10990452;11038176;11179213;11237011;11516400;11689439;11703925;11746448;11784320;11917121;12058051;12221131;12244319;12364329;12427552;12475894;12684051;12944476;12972505;15096524;15138286;1516130;15247254;15388334;15528189;15561770;15692570;15878329;15914536;15958533;16207721;16373702;16410077;16525024;16525121;16571673;16641372;16754960;16880209;16950109;17043139;17132146;17189207;17208202;17239822;17287728;17488286;17562788;17574030;17646400;17671165;17678623;18076383;18077418;18094055;18354496;18367545;1845915;18477474;18559336;18585354;18664496;18701652;18779367;18804435;1900457;19109890;19345684;19403694;19490898;19620288;19656848;19725050;19729655;19745841;20008558;20154091;20159109;20159556;20305638;20308558;20404108;20434987;20592283;20797862;20851765;20937701;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21951725;22013193;22065758;22072793;22171327;22365832;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23645161;23678941;23684622;23713133;23839779;24296415;24644286;24694596;24719330;24891604;24917561;24967941;25074980;25341920;25343031;25472813;25648148;25713415;25925668;26055712;26177209;26245486;26434594;26538022;26811146;26925400;26936971;26992070;27041585;27044746;27103185;27246931;27329675;27920218;28218747;28228285;28904123;29437277;29557506;30192525;30315122;30429286;31154438;31844290;32350084;32387766;33392160;33539396;33912179;33936100;33968037;34509645;35051231;36010968;36215666;38253038;7688123;7911226;8144603;8408203;8522602;8863739;9020086;9020161;9030515;9136770;9323142;9590177;9733780",
        "class_list": "",
        "function": "DOCK11 and DENND2A play pivotal roles in the maintenance of hepatitis B virus in host cells. Publication Status: Online-Only, [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport., [UniProtKB, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 39,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JUI3;Q1RMD5;Q86XY0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0015629 actin cytoskeleton",
        "go_biological_process": "GO:0015031 protein transport;GO:0042147 retrograde transport, endosome to Golgi",
        "synthesized_glycan_count": 0,
        "hit_score": 21.2,
        "record_id": "Q9ULE3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96IM9-1",
        "uniprot_id": "DYDC2_HUMAN",
        "mass": 20586.0,
        "length": 177,
        "protein_name": "DPY30 domain-containing protein 2",
        "gene_name": "DYDC2",
        "organism": "Human",
        "refseq_name": "DPY30 domain-containing protein 2 isoform 1",
        "refseq_ac": "NP_001256970",
        "gene_names_uniprotkb": "DYDC2",
        "gene_names_refseq": "DYDC2",
        "protein_names_uniprotkb": "DPY30 domain-containing protein 2",
        "protein_names_refseq": "DPY30 domain-containing protein 2 isoform 1; DPY30 domain-containing protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84332)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "11237011;18491316;31844290;35051231;35580925",
        "class_list": "",
        "function": "This gene encodes a member of a family of proteins that contains a DPY30 domain. This gene locus overlaps with a closely related gene on the opposite strand. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DWD6;Q5QP07;Q5QP11",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005930 axoneme;GO:0048188 Set1C/COMPASS complex",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q96IM9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P13762-1",
        "uniprot_id": "DRB4_HUMAN",
        "mass": 29941.0,
        "length": 266,
        "protein_name": "HLA class II histocompatibility antigen, DR beta 4 chain",
        "gene_name": "HLA-DRB4",
        "organism": "Human",
        "refseq_name": "major histocompatibility complex, class II, DR beta 4 precursor",
        "refseq_ac": "NP_068818",
        "gene_names_uniprotkb": "HLA-DRB4",
        "gene_names_refseq": "DR4; DRB4; HLA-DR4B; HLA-DRB4*; HLA-DRB4; HLA-DRB",
        "protein_names_uniprotkb": "HLA class II histocompatibility antigen, DR beta 4 chain; MHC class II antigen DRB4",
        "protein_names_refseq": "HLA class II histocompatibility antigen, DR beta 4 chain; MHC class II antigen DRB4; major histocompatibility complex, class II, DR beta 4 precursor",
        "tax_id": 9606,
        "disease": "aspirin-induced respiratory disease (Disease Ontology:DOID:0080822)",
        "pathway": " (hsa:3126);  (R-HSA-202424);  (R-HSA-202427);  (R-HSA-202430);  (R-HSA-202433);  (R-HSA-2132295);  (R-HSA-389948);  (R-HSA-877300)",
        "pathway_count": 8,
        "publication_count": 224,
        "publication_id_list": "10036229;10064083;10067896;10072072;10480952;10540230;10593899;10631941;10631952;10639150;10671560;10698680;10716940;10747096;10748235;10790433;10809954;10811803;10986460;11048639;11358993;11390650;11529500;11607830;11684289;11752630;11790530;11813165;11827988;11853874;11884229;11972023;11972878;12040185;12078484;12198549;12438563;12446674;12473184;12485116;12660731;12742663;12748383;12893276;12915721;12938237;12947224;1396683;14510693;14514672;14586410;14722222;14731593;15084594;1508672;15122200;15125833;15143187;15145317;15322115;15358536;15371334;15388922;15489910;15489916;15530433;15541657;15749704;15911768;16056267;16181339;16237089;16242130;16356853;16356855;16364187;16461343;16467876;16612002;16618111;16824007;16978534;17047224;17072321;17125875;17135271;17142755;17241953;17283181;17363905;17468049;17496917;17548359;17652306;17728323;18046453;18173375;18292509;18305173;18362138;18591661;18759926;19092054;19117940;19533806;1956401;19564404;20049711;20130243;20304997;20346773;20363976;21116285;21154117;2121367;21441454;21543337;2190094;22426112;23061660;23302904;23580664;2391366;24190977;24417533;2530588;25502872;28026046;28165004;28265006;28431892;29242379;29557506;29863979;3036826;30429286;30522017;3110774;31313098;31576671;31844290;31848261;32350084;32357974;32387766;32488085;32502341;32693207;32938616;32983136;33043033;33091337;33239784;33592498;33968037;34078123;34357683;34433824;34509645;3467350;34686989;35051231;35561310;35580925;36215666;37074911;7479848;7481823;7510216;7514165;7530745;7565724;7592972;7615558;7617032;7650016;7657660;7667286;7673114;7690989;7796299;8046351;8134367;8145819;8148318;8156998;8176225;8313912;8397411;8415765;8483949;8520027;8530158;8550590;8550631;8598037;8601309;8631301;8642258;8687433;8798379;8824201;8849454;8909537;8939989;8947036;9075930;9111318;9115214;9143706;9202021;9234493;9252186;9311912;9312039;9362451;9497313;9539769;9545226;9606180;9687533;9846482;9850860;9990853",
        "class_list": "",
        "function": "Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading., [UniProtKB]; Contribution of HLA class II genes, DRB4*01:01, DRB1*07:01, and DQB1*03:03:2 to clinical features of Vitiligo disease in Iranian population., [RefSeq, PubMed]; HLA-DR53 (DRB4 *01) associates with nickel sensitization., [RefSeq, PubMed]; HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020]., [RefSeq]; HLA-DRB4*01:14 is a null allele, and renamed HLA-DRB4*01:14N., [RefSeq, PubMed]; Strong association of nontumor anti-LGI1 encephalitis with HLA-DRB4., [RefSeq, PubMed]; We developed an human cardiac alpha-myosin -induced myocarditis model in human HLA-DR4 transgenic mice that lack all mouse MHCII genes., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 9562,
        "biomarker_type": "",
        "glycan_count": 11,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0S863;O78042;P79664;Q29889;Q30163;Q6TLK6;Q860N4;Q861F3;Q8WLT9;Q9BS54",
        "ec_number_list": "",
        "go_molecular_function": "GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane;GO:0005765 lysosomal membrane;GO:0030658 transport vesicle membrane",
        "go_biological_process": "GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0002250 adaptive immune response;GO:0050870 positive regulation of T cell activation;GO:0050778 positive regulation of immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 23.7,
        "record_id": "P13762-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A6NC42-1",
        "uniprot_id": "DPPA5_HUMAN",
        "mass": 13498.0,
        "length": 116,
        "protein_name": "Developmental pluripotency-associated 5 protein",
        "gene_name": "DPPA5",
        "organism": "Human",
        "refseq_name": "developmental pluripotency-associated 5 protein",
        "refseq_ac": "NP_001020461",
        "gene_names_uniprotkb": "DPPA5; ESG1",
        "gene_names_refseq": "DPPA5; ESG1",
        "protein_names_uniprotkb": "Developmental pluripotency-associated 5 protein; ESG-1; Embryonal stem cell-specific gene 1 protein; hDPPA5",
        "protein_names_refseq": "developmental pluripotency-associated 5 protein; embryonal stem cell specific gene 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:340168)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "15790765;17913455;26661329",
        "class_list": "",
        "function": "Dppa5 is specifically and differentially expressed in human cells that have pluripotency and can be used as a marker of pluripotent stem cells., [RefSeq, PubMed]; Involved in the maintenance of embryonic stem (ES) cell pluripotency. Dispensable for self-renewal of pluripotent ES cells and establishment of germ cells. Associates with specific target mRNAs (By similarity)., [UniProtKB]; Our study provides new insight into the function of DPPA5 and NANOG regulation in human pluripotent stem cell ., [RefSeq, PubMed]; This gene encodes a protein that may function in the control of cell pluripotency and early embryogenesis. Expression of this gene is a specific marker for pluripotent stem cells. Pseudogenes of this gene are located on the short arm of chromosome 10 and the long arm of chromosomes 14 and 19. [provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RPQ7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003729 mRNA binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0010468 regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "A6NC42-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A6NFQ7-1",
        "uniprot_id": "DPRX_HUMAN",
        "mass": 21648.0,
        "length": 191,
        "protein_name": "Divergent paired-related homeobox",
        "gene_name": "DPRX",
        "organism": "Human",
        "refseq_name": "divergent paired-related homeobox",
        "refseq_ac": "NP_001012746",
        "gene_names_uniprotkb": "DPRX",
        "gene_names_refseq": "DPRX",
        "protein_names_uniprotkb": "Divergent paired-related homeobox",
        "protein_names_refseq": "divergent paired-related homeobox",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:503834)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "17005330;27412763;28228285;34019948",
        "class_list": "",
        "function": "Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DPRX homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor that acts as a repressor., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "A6NFQ7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P09884-1",
        "uniprot_id": "DPOLA_HUMAN",
        "mass": 165913.0,
        "length": 1462,
        "protein_name": "DNA polymerase alpha catalytic subunit",
        "gene_name": "POLA1",
        "organism": "Human",
        "refseq_name": "DNA polymerase alpha catalytic subunit isoform 2",
        "refseq_ac": "NP_058633",
        "gene_names_uniprotkb": "POLA1; POLA",
        "gene_names_refseq": "NSX; PDR; POLA1; POLA; VEODS; p180",
        "protein_names_uniprotkb": "DNA polymerase alpha catalytic subunit; 2.7.7.7; DNA polymerase alpha catalytic subunit p180",
        "protein_names_refseq": "DNA polymerase alpha catalytic subunit isoform 2; DNA polymerase alpha catalytic subunit p180; polymerase (DNA directed), alpha 1, catalytic subunit; polymerase (DNA) alpha 1, catalytic subunit; polymerase (DNA-directed), alpha (70kD)",
        "tax_id": 9606,
        "disease": "X-linked reticulate pigmentary disorder (Disease Ontology:DOID:0111834); Van Esch-O'Driscoll syndrome (Disease Ontology:DOID:0111840)",
        "pathway": " (hsa:5422);  (R-HSA-113501);  (R-HSA-174411);  (R-HSA-174430);  (R-HSA-68952);  (R-HSA-68962);  (R-HSA-69091);  (R-HSA-69166);  (R-HSA-69183);  (R-HSA-69205);  (R-HSA-9710421)",
        "pathway_count": 11,
        "publication_count": 173,
        "publication_id_list": "10.1101/2023.09.13.557529;10228158;10329413;10373557;10454584;10518787;10523313;10597240;10656791;10656792;10692433;10751307;10757793;10846177;10882098;11003670;11095689;11125146;11237011;11473323;11724925;11959842;11988738;12045100;12766176;12782299;12930902;1328683;14499601;14527418;14766746;14990995;15014447;15066120;15510213;16314528;1671046;1682322;17699597;17991896;18223688;18346456;18669648;19007248;19413330;19608746;19651622;19661920;19690332;1974050;19854130;19896182;2005899;20068231;20639858;21406692;2165567;2243771;22544926;22645359;22871736;23186163;24038470;24115439;24366607;24714562;24715725;25231993;25505266;25576301;25645385;25810538;25880248;25892735;26024233;26811146;26975377;26992070;27019227;27600516;27846572;28334750;28352266;28371302;28404884;28904123;29437277;29493099;29555682;29557506;29774655;30026550;3025630;30315122;30379171;30484775;30993897;31006512;31217245;31844290;32157095;32188940;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;3359994;33633747;33691108;33717175;33731801;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34357683;34376693;34405274;34509645;34561969;34932366;35051231;35318648;35561310;35580925;36010968;36215666;36241641;36581221;37074911;37938771;6094569;6693436;7378348;7623816;7644508;7711022;7713898;7876218;7929342;8104944;8114698;8131753;8144677;8288595;8618861;893425;8943353;8954124;9020173;9081985;9191022;9214288;9518481;9520412;9660172;9660782;9662327;9705292;9778043;9822671",
        "class_list": "",
        "function": "Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses (PubMed:27019227)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Defective DNA Polymerase alpha-Primase Leads to X-Linked Intellectual Disability Associated with Severe Growth Retardation, Microcephaly, and Hypogonadism., [RefSeq, PubMed]; Detailed structural comparison of Polalpha with other replicative DNA polymerases disclosed common features and some differences, which may reflect the specialization of each polymerase in genome replication, [RefSeq, PubMed]; Pol alpha-primase dependent nuclear localization of the mammalian CST complex. Publication Status: Online-Only, [RefSeq, PubMed]; Small tandem DNA duplications result from CST-guided Pol alpha-primase action at DNA break termini. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010]., [RefSeq]; We propose that completely skewed XCI favoring the normal X chromosome resulted from death of cells with an active derivative X that was caused by a non-functional POLA1 gene. In summary, we conclude that functional monosomy of 6q27-qter and functional disomy of Xpter-p22.11 are responsible for the clinical phenotype of the patient, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86UQ7",
        "ec_number_list": "2.7.11.1;2.7.7.49;3.1.21.-;2.7.7.7;5.6.2.4;2.7.7.31;4.2.99.18;4.2.99.-;3.1.26.4;3.4.23.50;2.7.11.22;3.6.4.12;3.1.11.-;3.1.-.-;2.7.7.-;2.7.7.102",
        "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003887 DNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005658 alpha DNA polymerase:primase complex;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005730 nucleolus",
        "go_biological_process": "GO:0006271 DNA strand elongation involved in DNA replication;GO:0006272 leading strand elongation;GO:0006273 lagging strand elongation;GO:0006281 DNA repair;GO:0006260 DNA replication",
        "synthesized_glycan_count": 0,
        "hit_score": 18.3,
        "record_id": "P09884-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A6NNS2-1",
        "uniprot_id": "DRS7C_HUMAN",
        "mass": 34878.0,
        "length": 312,
        "protein_name": "Dehydrogenase/reductase SDR family member 7C",
        "gene_name": "DHRS7C",
        "organism": "Human",
        "refseq_name": "dehydrogenase/reductase SDR family member 7C isoform 2 precursor",
        "refseq_ac": "NP_001099041",
        "gene_names_uniprotkb": "DHRS7C; SDR32C2",
        "gene_names_refseq": "DHRS7C; SDR32C2",
        "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 7C; 1.1.1.105; Protein SDR32C2; Protein SRP-35; Sarcoplasmic reticulum protein of 35 kDa; Short-chain dehydrogenase/reductase family 32C member 2",
        "protein_names_refseq": "dehydrogenase/reductase (SDR family) member 7C; dehydrogenase/reductase SDR family member 7C isoform 2 precursor; sarcoplasmic reticulum protein of 35 kDa; short-chain dehydrogenase/reductase family 32C member 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:201140)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11237011;19027726;22143674;24715725;27397612;29393594;29557506",
        "class_list": "",
        "function": "NADH-dependent oxidoreductase which catalyzes the oxidation of all-trans-retinol to all-trans-retinal. Plays a role in the regulation of cardiac and skeletal muscle metabolic functions. Maintains Ca(2+) intracellular homeostasis by repressing Ca(2+) release from the sarcoplasmic reticulum (SR) in myotubes, possibly through local alternations in NAD/NADH or retinol/retinal. Also plays a role in Ca(2+) homeostasis by controlling Ca(2+) overload in the cytosol and the SR in myotubes. Involved in glucose uptake into skeletal muscles and muscle performance by activating PI3K and mTORC2-mediated AKT1 phosphorylation signaling pathways, possibly through the action of its downstream catalytic product all-trans-retinoic acid., [UniProtKB, UniProtKB]; The expression of DHRS7c, a novel endo/sarcoplasmic reticulum-localized a short chain dehydrogenase/reductase, is inversely correlated with adrenergic stimulation and heart failure development., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZW74;B9EJH3",
        "ec_number_list": "1.1.1.105;1.1.1.62;1.1.1.239;1.1.1.209;1.1.1.53;1.1.1.315;1.1.1.1;1.1.1.66;1.1.1.-",
        "go_molecular_function": "GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0016491 oxidoreductase activity",
        "go_cellular_component": "GO:0033017 sarcoplasmic reticulum membrane;GO:0014801 longitudinal sarcoplasmic reticulum",
        "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0098708 D-glucose import across plasma membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "A6NNS2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "C9JQL5-1",
        "uniprot_id": "DSA2D_HUMAN",
        "mass": 14796.0,
        "length": 133,
        "protein_name": "Putative dispanin subfamily A member 2d",
        "gene_name": "",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative dispanin subfamily A member 2d; DSPA2d",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "22363774;25880248;28510447;31611695;32350084",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0060337 type I interferon-mediated signaling pathway;GO:0034341 response to type II interferon;GO:0035455 response to interferon-alpha",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "C9JQL5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y485-1",
        "uniprot_id": "DMXL1_HUMAN",
        "mass": 337839.0,
        "length": 3027,
        "protein_name": "DmX-like protein 1",
        "gene_name": "DMXL1",
        "organism": "Human",
        "refseq_name": "dmX-like protein 1 isoform 1",
        "refseq_ac": "NP_001277250",
        "gene_names_uniprotkb": "DMXL1; XL1",
        "gene_names_refseq": "DMXL1",
        "protein_names_uniprotkb": "DmX-like protein 1; X-like 1 protein",
        "protein_names_refseq": "dmX-like protein 1 isoform 1; dmX-like protein 1",
        "tax_id": 9606,
        "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); dilated cardiomyopathy (Disease Ontology:DOID:12930); temporal arteritis (Disease Ontology:DOID:13375); congenital heart disease (Disease Ontology:DOID:1682); multiple sclerosis (Disease Ontology:DOID:2377); pulmonary fibrosis (Disease Ontology:DOID:3770); tetralogy of Fallot (Disease Ontology:DOID:6419); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398); Alagille syndrome (Disease Ontology:DOID:9245)",
        "pathway": " (hsa:1657)",
        "pathway_count": 1,
        "publication_count": 92,
        "publication_id_list": "10708522;11237011;18452278;18669648;19413330;19651622;19664994;19690332;20068231;21406692;23186163;23481700;24275569;24366607;24714562;24715725;25418920;25548167;25576301;25645385;25880248;25892735;26154972;26375851;26929215;26992070;27846572;27862975;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29351928;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30379171;30410026;30429286;30484775;30524438;31154438;31217245;31530632;31844290;31848261;31998317;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33717175;33912179;33968037;33981976;34087483;34171305;34357683;34509645;34561969;34932366;35051231;35154160;35494241;35580925;36010968;36241641;36284347;36581221;37217939;38253038",
        "class_list": "",
        "function": "The protein encoded by this gene is a member of the WD repeat superfamily of proteins, which have regulatory functions. This gene is expressed in many tissue types including several types of eye tissue, and it has been associated with ocular phenotypes. In addition, it is upregulated in cultured cells that overexpress growth factor independence 1B, a transcription factor that is essential for hematopoietic cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 75,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 11,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0043291 RAVE complex",
        "go_biological_process": "GO:0007035 vacuolar acidification",
        "synthesized_glycan_count": 0,
        "hit_score": 9.9,
        "record_id": "Q9Y485-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14531-1",
        "uniprot_id": "DPYL4_HUMAN",
        "mass": 61878.0,
        "length": 572,
        "protein_name": "Dihydropyrimidinase-related protein 4",
        "gene_name": "DPYSL4",
        "organism": "Human",
        "refseq_name": "dihydropyrimidinase-related protein 4",
        "refseq_ac": "NP_006417",
        "gene_names_uniprotkb": "DPYSL4; CRMP3; ULIP4",
        "gene_names_refseq": "CRMP3; DPYSL4; DRP-4; ULIP4",
        "protein_names_uniprotkb": "Dihydropyrimidinase-related protein 4; CRMP-3; Collapsin response mediator protein 3; DRP-4; ULIP-4; UNC33-like phosphoprotein 4",
        "protein_names_refseq": "CRMP-3; ULIP-4; UNC33-like phosphoprotein 4; collapsin response mediator protein 3; dihydropyrimidinase-related protein 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10570);  (R-HSA-399956)",
        "pathway_count": 2,
        "publication_count": 31,
        "publication_id_list": "11237011;12093729;12372285;14685275;15652488;15676027;17525332;17607942;17607944;25358863;27846572;28467828;28514659;28834231;28855257;29242379;29485866;29493099;29557506;30061407;31154438;31844290;31848261;32350084;32938616;33592498;33968037;35051231;35318648;35877019;9652388",
        "class_list": "",
        "function": "DPYSL4 plays a key role in the tumor-suppressor function of p53 by regulating oxidative phosphorylation and the cellular energy supply via its association with mitochondrial supercomplexes, possibly linking to the pathophysiology of both cancer and obesity., [RefSeq, PubMed]; Identification of Metabolic Syndrome-Related miRNA-mRNA Regulatory Networks and Key Genes Based on Bioinformatics Analysis., [RefSeq, PubMed]; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity)., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RMQ1;D3DRG5;O00240;Q5T0Q7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031005 filamin binding;GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0007399 nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "O14531-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75417-1",
        "uniprot_id": "DPOLQ_HUMAN",
        "mass": 289619.0,
        "length": 2590,
        "protein_name": "DNA polymerase theta",
        "gene_name": "POLQ",
        "organism": "Human",
        "refseq_name": "DNA polymerase theta",
        "refseq_ac": "NP_955452",
        "gene_names_uniprotkb": "POLQ; POLH",
        "gene_names_refseq": "POLQ; PRO0327",
        "protein_names_uniprotkb": "DNA polymerase theta; 2.7.7.49; DNA polymerase eta; RNA-directed DNA polymerase POLQ",
        "protein_names_refseq": "DNA polymerase theta; epididymis secretory sperm binding protein; polymerase (DNA directed), theta; polymerase (DNA) theta",
        "tax_id": 9606,
        "disease": "breast cancer (Disease Ontology:DOID:1612)",
        "pathway": " (hsa:10721);  (R-HSA-5685939)",
        "pathway_count": 2,
        "publication_count": 115,
        "publication_id_list": "10395804;11237011;11340072;11440997;12051913;14576298;14735462;15135726;15561706;15944288;16012167;18452278;18503084;18691976;19007248;19188258;19357644;19608861;20483915;20624954;20647759;20700469;21050863;21816818;22135286;23481700;24648516;24715725;24989122;25201414;25409685;25418920;25576301;25642960;25642963;25643323;25775267;25789972;25880248;26154972;26375851;26636256;26758079;26811146;26929215;26992070;27311885;27591252;27846572;27920218;28063628;28218747;28228285;28514659;28695890;28832583;28834231;28855257;28904123;29133916;29208956;29242379;29393594;29437277;29444826;29493099;29632046;30315122;30379171;30655289;31530632;31562312;31844290;31937595;31998317;32157095;32234782;32350084;32357974;32387766;32502341;32873648;32897882;32938616;33141586;33298915;33577776;33912179;33936100;33968037;34087483;34117057;34140467;34171305;34179826;34211107;34616022;35051231;35251023;35580925;36010968;36215666;36241641;36455556;37217939;37440612;37674080;38575587;38640889;38640897;38671548;38782541;38876299;8003475;9214649",
        "class_list": "",
        "function": "DNA Pol theta has a specialized function in lymphocytes and in tumor progression, [RefSeq, PubMed]; DNA polymerase theta purified from human cells is a high-fidelity enzyme., [RefSeq, PubMed]; Dynamic stem-loop extension by Pol theta; and templated insertion during DNA repair., [RefSeq, PubMed]; Exosomal circPOLQ promotes macrophage M2 polarization via activating IL-10/STAT3 axis in a colorectal cancer model. Publication Status: Online-Only, [RefSeq, PubMed]; Human DNA polymerase theta; does not harbor intrinsic nuclease activity., [RefSeq, PubMed]; Low-fidelity DNA polymerase with a putative helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery required to repair double-strand breaks in DNA during mitosis (PubMed:14576298, PubMed:18503084, PubMed:24648516, PubMed:25642963, PubMed:25643323, PubMed:25775267, PubMed:26636256, PubMed:27311885, PubMed:27591252, PubMed:30655289, PubMed:31562312, PubMed:32873648, PubMed:34140467, PubMed:34179826, PubMed:36455556, PubMed:37440612, PubMed:37674080). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252, PubMed:31562312, PubMed:32873648). MMEJ is required during mitosis to repair persistent double-strand breaks that originate in S-phase (PubMed:37440612, PubMed:37674080). Although error-prone, MMEJ protects against chromosomal instability and tumorigenesis (By similarity). The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). It then extends each strand from the base-paired region using the opposing overhang as a template (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). The polymerase lacks proofreading activity and is highly promiscuous: unlike most polymerases, promotes extension of ssDNA and partial ssDNA (pssDNA) substrates (PubMed:18503084, PubMed:21050863, PubMed:22135286). When the ends of a break do not contain terminal microhomology must identify embedded complementary sequences through a scanning step (PubMed:32234782). Promotes dissociation of the replication protein A complex (RPA/RP-A), composed of RPA1, RPA2 and RPA3, from resected double-strand breaks to allow their annealing and subsequent joining by MMEJ (PubMed:36455556). Removal of RPA/RP-A complex proteins prevents RAD51 accumulation at resected ends, thereby inhibiting homology-recombination repair (HR) pathway (PubMed:25642963, PubMed:28695890). Also shows RNA-directed DNA polymerase activity to mediate DNA repair in vitro; however this activity needs additional evidence in vivo (PubMed:34117057). May also have lyase activity (PubMed:19188258). Involved in somatic hypermutation of immunoglobulin genes, a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (By similarity). POLQ-mediated end joining activity is involved in random integration of exogenous DNA hampers (PubMed:28695890). DNA helicase activity has been examined and has (PubMed:29444826) and has not (PubMed:14576298, PubMed:36455556) been demonstrated (PubMed:14576298, PubMed:29444826, PubMed:36455556)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Melanoma-Derived DNA Polymerase Theta Variants Exhibit Altered DNA Polymerase Activity., [RefSeq, PubMed]; POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase. Publication Status: Online-Only, [RefSeq, PubMed]; The isolation of the full-length human DNA POLQ gene, and an initial characterization of its gene product, DNA polymerase theta, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 76,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O95160;Q6VMB5",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;2.7.7.49;3.1.21.-;2.7.7.7;3.6.4.6;3.6.1.5;3.6.4.10;2.7.7.31;3.1.3.1;3.9.1.1;4.2.99.18;4.2.99.-;3.1.26.4;3.4.23.50;5.6.1.6;5.6.2.3;3.6.4.12;3.1.11.-;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;2.7.7.102;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0000287 magnesium ion binding;GO:0003682 chromatin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0042645 mitochondrial nucleoid;GO:0035861 site of double-strand break;GO:0090734 site of DNA damage",
        "go_biological_process": "GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006281 DNA repair;GO:0051260 protein homooligomerization;GO:0006284 base-excision repair",
        "synthesized_glycan_count": 0,
        "hit_score": 11.9,
        "record_id": "O75417-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95147-1",
        "uniprot_id": "DUS14_HUMAN",
        "mass": 22255.0,
        "length": 198,
        "protein_name": "Dual specificity protein phosphatase 14",
        "gene_name": "DUSP14",
        "organism": "Human",
        "refseq_name": "dual specificity protein phosphatase 14",
        "refseq_ac": "NP_008957",
        "gene_names_uniprotkb": "DUSP14; MKP6",
        "gene_names_refseq": "DUSP14; MKP-L; MKP6",
        "protein_names_uniprotkb": "Dual specificity protein phosphatase 14; 3.1.3.16; 3.1.3.48; MAP kinase phosphatase 6; MKP-1-like protein tyrosine phosphatase; MKP-6; MKP-L; Mitogen-activated protein kinase phosphatase 6",
        "protein_names_refseq": "MAP kinase phosphatase 6; MKP-1-like protein tyrosine phosphatase; MKP-6; dual specificity protein phosphatase 14; mitogen-activated protein kinase phosphatase 6",
        "tax_id": 9606,
        "disease": "chromosome 17q12 deletion syndrome (Disease Ontology:DOID:0060404); pulmonary tuberculosis (Disease Ontology:DOID:2957)",
        "pathway": " (hsa:11072)",
        "pathway_count": 1,
        "publication_count": 77,
        "publication_id_list": "11123293;17178844;18201568;18669648;19770498;21136679;22424782;22544926;24403530;24715725;25576301;25645385;26154972;26521044;26811146;26891723;26938665;26992070;27600516;27862975;28218747;28228285;28832583;28834231;28855257;28904123;29077210;29242379;29437277;29493099;29508533;29557506;29786170;30315122;30335891;30379171;30410026;30429286;30484775;30524438;30779550;31154438;31222486;31844290;31848261;31937595;31998317;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33936100;33968037;33981976;34087483;34171305;34211107;34405274;34509645;35051231;35561310;35580925;36010968;36215666;36241641;36284347;40596516",
        "class_list": "",
        "function": "Activation of ATM by radiation down-regulates phospho-ERK1/2 and its downstream signaling via increased expression of mitogen-activated protein kinase phosphatase MKP-1., [RefSeq, PubMed]; Bioinformatic studies showed that these two miRNAs target PTEN and DUSP14 tumor suppressor genes. Quantitative Real-time PCR confirmed the overexpression of the miRNAs and downregulation of their targets. Luciferase assay confirmed that the miRNAs target PTEN and DUSP14., [RefSeq, PubMed]; Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]., [RefSeq]; Hepatocyte DUSP14 is required for maintaining hepatic metabolic homeostasis and for suppressing inflammation, a novel function that relies on constraining TAK1 hyperactivation, [RefSeq, PubMed]; Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases. Plays a negative role in TCR signaling by dephosphorylating MAP3K7 adapter TAB1 leading to its inactivation (PubMed:24403530)., [UniProtKB, PubMed]; Levels significantly decreased in failing hearts, [RefSeq, PubMed]; The AA genotype was associated with protection against active TB.  Among disease-free individuals, T-helper type-1 related genes, IFNGR2 and STAT1 mRNA levels significantly increased as the number of A alleles of rs1051838 increased., [RefSeq, PubMed]; The binding of Lipomannan to TLR2 triggers MAPK activation, followed by an up-regulation of MKP-1 expression, which in turn may act as a negative regulator of MAPK activation., [RefSeq, PubMed]; The overproduction, purification and crystal structure at 1.88 A resolution of human dual-specificity phosphatase 14, DUSP14 (MKP6), are reported., [RefSeq, PubMed]; These findings reveal a novel mechanism by which TRAF2 mediates Lys63-linked ubiquitination of DUSP14, leading to DUSP14 activation in T cells, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.21;3.1.3.18;3.1.3.-;3.1.3.5;3.1.3.2;2.7.10.1;3.1.3.67;3.1.3.53;3.1.3.52;3.1.3.27;3.1.3.86;3.1.3.36;3.1.3.74",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 8.0,
        "record_id": "O95147-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0CJ86-1",
        "uniprot_id": "DU4L3_HUMAN",
        "mass": 44926.0,
        "length": 424,
        "protein_name": "Double homeobox protein 4-like protein 3",
        "gene_name": "DUX4L3",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DUX4L3",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Double homeobox protein 4-like protein 3",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "P0CJ86-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0CJ88-1",
        "uniprot_id": "DU4L5_HUMAN",
        "mass": 44926.0,
        "length": 424,
        "protein_name": "Double homeobox protein 4-like protein 5",
        "gene_name": "DUX4L5",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DUX4L5",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Double homeobox protein 4-like protein 5",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "P0CJ88-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P33316-3",
        "uniprot_id": "DUT_HUMAN",
        "mass": 26563.0,
        "length": 252,
        "protein_name": "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial",
        "gene_name": "DUT",
        "organism": "Human",
        "refseq_name": "deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform 1 precursor",
        "refseq_ac": "NP_001020419",
        "gene_names_uniprotkb": "DUT",
        "gene_names_refseq": "BMFDMS; DUT; dUTPase",
        "protein_names_uniprotkb": "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; 3.6.1.23; dUTP pyrophosphatase; dUTPase",
        "protein_names_refseq": "dUTP diphosphatase; dUTP nucleotidohydrolase; dUTP pyrophosphatase; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform 1 precursor; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial",
        "tax_id": 9606,
        "disease": "multiple endocrine neoplasia type 1 (Disease Ontology:DOID:10017); hyperparathyroidism (Disease Ontology:DOID:13543); cancer (Disease Ontology:DOID:162); congenital heart disease (Disease Ontology:DOID:1682); pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); prolactinoma (Disease Ontology:DOID:5394); gastrinoma (Disease Ontology:DOID:5577); growth hormone secreting pituitary adenoma (Disease Ontology:DOID:6255); duodenal gastrinoma (Disease Ontology:DOID:7959); bone marrow failure and diabetes mellitus syndrome (MONDO:MONDO:0859288)",
        "pathway": " (hsa:1854)",
        "pathway_count": 1,
        "publication_count": 106,
        "publication_id_list": "10.1038/emboj.2013.79;10203015;11875071;1325640;15104674;16964243;17081983;17145369;17880943;18669648;19615748;20068231;23186163;23301498;23481700;23584533;24275569;24714562;24715725;25418920;25469497;25505266;25576301;25810538;25880248;26154972;26375851;26728094;26929215;26992070;27846572;27869121;27920218;28063628;28073829;28218747;28228285;28649982;28832583;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30192525;30315122;30379171;30410026;30779550;30833945;31154438;31217245;31530632;31611695;31844290;31848261;31998317;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32983136;33141586;33298915;33633747;33912179;33936100;34019948;34087483;34171305;34211107;34229054;34357683;34433824;34509645;34584184;34932366;35051231;35083852;35251023;35318648;35494241;35580925;35611808;35931051;36241641;36426924;37173337;37938771;38665916;39477983;8389461;8631816;8631817;8805593;9070952;9228092",
        "class_list": "",
        "function": "Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (PubMed:17880943, PubMed:8631816, PubMed:8805593). Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]; DUT enhances drug resistance to proteasome inhibitors via promoting mitochondrial function in multiple myeloma., [RefSeq, PubMed]; Discovery of two new isoforms of the human DUT gene. Publication Status: Online-Only, [RefSeq, PubMed]; Redox status of cysteines does not alter functional properties of human dUTPase but the Y54C mutation involved in monogenic diabetes decreases protein stability. Erratum:[Sci Rep. 2021 Oct 29;11(1):21666. doi: 10.1038/s41598-021-01241-2. PMID: 34716399] Publication Status: Online-Only, [RefSeq, PubMed]; Structural dynamics of human deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase). Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 6,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 11,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K650;B4DPR5;O14785;Q16708;Q16860;Q6FHN1;Q6NSA3;Q96Q81",
        "ec_number_list": "3.6.1.23",
        "go_molecular_function": "GO:0030547 signaling receptor inhibitor activity;GO:0032556 pyrimidine deoxyribonucleotide binding;GO:0000287 magnesium ion binding;GO:0003723 RNA binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006226 dUMP biosynthetic process;GO:0006231 dTMP biosynthetic process;GO:0046081 dUTP catabolic process;GO:0001889 liver development;GO:0006260 DNA replication",
        "synthesized_glycan_count": 0,
        "hit_score": 11.3,
        "record_id": "P33316-3",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P35462-1",
        "uniprot_id": "DRD3_HUMAN",
        "mass": 44195.0,
        "length": 400,
        "protein_name": "D(3) dopamine receptor",
        "gene_name": "DRD3",
        "organism": "Human",
        "refseq_name": "D(3) dopamine receptor isoform a",
        "refseq_ac": "NP_000787",
        "gene_names_uniprotkb": "DRD3",
        "gene_names_refseq": "D3DR; DRD3; ETM1; FET1",
        "protein_names_uniprotkb": "D(3) dopamine receptor; Dopamine D3 receptor",
        "protein_names_refseq": "D(3) dopamine receptor isoform a; essential tremor 1",
        "tax_id": 9606,
        "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); nicotine dependence (Disease Ontology:DOID:0050742); absence epilepsy (Disease Ontology:DOID:0070309); Parkinsonism (Disease Ontology:DOID:0080855); essential tremor 1 (Disease Ontology:DOID:0111428); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); amnestic disorder (Disease Ontology:DOID:10914); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); essential tremor (Disease Ontology:DOID:4990); schizophrenia (Disease Ontology:DOID:5419); heroin dependence (Disease Ontology:DOID:9976)",
        "pathway": " (hsa:1814);  (R-HSA-390651);  (R-HSA-418594)",
        "pathway_count": 3,
        "publication_count": 46,
        "publication_id_list": "10391209;10578130;10739409;11007482;11237011;12120503;1362221;14060771;15951850;16386234;16634148;16650084;16809426;16923326;1826762;1840645;18434541;18577758;19217379;19520868;20068231;21097933;2129115;2144334;2532362;2534964;26460884;2748346;27659709;2834384;29242379;31538542;35494241;38363619;38431040;38927672;39187246;39300138;39984436;7937899;7961889;8015379;8406495;8415635;9034004;9514583",
        "class_list": "",
        "function": "A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities. Erratum:[Commun Biol. 2025 Feb 23;8(1):293. doi: 10.1038/s42003-025-07723-7. PMID: 39988590] Publication Status: Online-Only, [RefSeq, PubMed]; Association Study Between DRD2, DRD3 Genetic Polymorphisms and Adverse Reactions in Chinese Patients on Amisulpride Treatment., [RefSeq, PubMed]; Association of dopamine receptor D3 polymorphism with Levodopa-induced Dyskinesia: A study on Parkinson's disease patients from India., [RefSeq, PubMed]; DRD3 Predicts Cognitive Impairment and Anxiety in Parkinson's Disease: Susceptibility and Protective Effects., [RefSeq, PubMed]; Dopamine receptor that is primarily expressed in limbic areas of the brain and is involved in the modulation of cognitive, emotional, and endocrine functions (PubMed:39984436). Plays a key role in regulating neuronal signaling pathways associated with motivation, reward, and behavior (PubMed:39984436). Coupled to G(i)/G(o) proteins; activation leads to inhibition of adenylate cyclase and decreased intracellular cAMP levels (PubMed:10578130). Involved in the control of locomotor activity and implicated in several neuropsychiatric disorders, including schizophrenia and substance use disorders (PubMed:39984436). Promotes cell proliferation through MAP kinase signaling (PubMed:19520868). Also involved in autophagy regulation: receptor activation stimulates AMPK, which phosphorylates RPTOR and enhances its interaction with MTOR, thereby inhibiting MTORC1 signaling and its downstream target RPS6KB1. This leads to activation of ULK1 and initiation of the autophagy cascade (PubMed:31538542). Forms heterotetramers with DRD1 to potentiate beta-arrestin recruitment and mediate locomotor activity (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Polymorphisms in the Dopaminergic Receptor D3 Gene Correlate with Disease Progression Rate in Relapsing-Remitting Multiple Sclerosis Patients. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 31,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 13,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1A4V5;Q4VBM8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go;GO:0004930 G protein-coupled receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse",
        "go_biological_process": "GO:0034776 response to histamine;GO:0046717 acid secretion;GO:0050709 negative regulation of protein secretion;GO:0051584 regulation of dopamine uptake involved in synaptic transmission;GO:0060158 phospholipase C-activating dopamine receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "P35462-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P56177-1",
        "uniprot_id": "DLX1_HUMAN",
        "mass": 27320.0,
        "length": 255,
        "protein_name": "Homeobox protein DLX-1",
        "gene_name": "DLX1",
        "organism": "Human",
        "refseq_name": "homeobox protein DLX-1 isoform 2",
        "refseq_ac": "NP_001033582",
        "gene_names_uniprotkb": "DLX1",
        "gene_names_refseq": "DLX1",
        "protein_names_uniprotkb": "Homeobox protein DLX-1",
        "protein_names_refseq": "distal-less homeo box 1; homeobox protein DLX-1 isoform 2; homeobox protein DLX-1",
        "tax_id": 9606,
        "disease": "Paget's disease of bone (Disease Ontology:DOID:5408); systemic lupus erythematosus (Disease Ontology:DOID:9074)",
        "pathway": " (hsa:1745)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11237011;14671321;29393594;29485866;30379171;30833945;31026217;32350084;32681273;34472106;34493733;38317839;7907794",
        "class_list": "",
        "function": "DLX1 acts as a novel prognostic biomarker involved in immune cell infiltration and tumor progression in lung adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; DLX1 may function as a regulator of multiple signals from TGF-beta superfamily members in broad biological contexts during blood production, [RefSeq, PubMed]; MiR-129-5p/DLX1 signalling axis mediates functions of prostate cancer during malignant progression., [RefSeq, PubMed]; Plays a role as a transcriptional activator or repressor (PubMed:14671321). Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (PubMed:14671321). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity). Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity)., [UniProtKB, PubMed, UniProtKB]; Prospective assessment of two-gene urinary test with multiparametric magnetic resonance imaging of the prostate for men undergoing primary prostate biopsy., [RefSeq, PubMed]; This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; Urinary DLX1 mRNA levels were quantified and RNA results were then combined with other risk factors in a clinical model optimized to detect International Society of Urological Pathology Grade Group 2 or greater prostate cancer in men with prostate specific antigen less than 10 ng/ml., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DPD7;Q53ZU4;Q7Z724;Q8IYB2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus;GO:0046533 negative regulation of photoreceptor cell differentiation;GO:1902871 positive regulation of amacrine cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "P56177-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P59022-1",
        "uniprot_id": "DSC10_HUMAN",
        "mass": 9286.0,
        "length": 87,
        "protein_name": "Down syndrome critical region protein 10",
        "gene_name": "DSCR10",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DSCR10",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Down syndrome critical region protein 10",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "12168953;25892735",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q52LN2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "P59022-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P59910-1",
        "uniprot_id": "DJB13_HUMAN",
        "mass": 36118.0,
        "length": 316,
        "protein_name": "DnaJ homolog subfamily B member 13",
        "gene_name": "DNAJB13",
        "organism": "Human",
        "refseq_name": "dnaJ homolog subfamily B member 13 isoform 1",
        "refseq_ac": "NP_705842",
        "gene_names_uniprotkb": "DNAJB13; TSARG3; TSARG6",
        "gene_names_refseq": "CILD34; DNAJB13; RSPH16A; TSARG5; TSARG6",
        "protein_names_uniprotkb": "DnaJ homolog subfamily B member 13; Testis and spermatogenesis cell-related protein 6; Testis spermatocyte apoptosis-related gene 6 protein; Testis spermatogenesis apoptosis-related gene 3 protein; Testis spermatogenesis apoptosis-related gene 6 protein",
        "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 13; DnaJ (Hsp40) related, subfamily B, member 13; DnaJ-like protein; dnaJ homolog subfamily B member 13 isoform 1; dnaJ homolog subfamily B member 13; radial spoke 16 homolog A; testis and spermatogenesis cell-related protein 6; testis spermatocyte apoptosis-related gene 6 protein; testis spermatogenesis apoptosis-related gene 3 protein; testis spermatogenesis apoptosis-related gene 6 protein",
        "tax_id": 9606,
        "disease": "congenital myopathy 21 (Disease Ontology:DOID:0081353); autosomal dominant limb-girdle muscular dystrophy type 1 (Disease Ontology:DOID:0110305); primary ciliary dyskinesia 34 (Disease Ontology:DOID:0110610)",
        "pathway": " (hsa:374407)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11237011;12673577;14970903;27486783;29393594;31342671;35166991;35494241;37217939;39894887",
        "class_list": "",
        "function": "A novel homozygous mutation in DNAJB13-a gene associated with the sperm axoneme-leads to teratozoospermia., [RefSeq, PubMed]; Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia., [UniProtKB, PubMed]; Missense mutation in DNAJB13 gene correlated with male fertility in asthenozoospermia., [RefSeq, PubMed]; TSARG6 is specifically expressed in adult testis with a transcript of 1.8 kb, which has a role in spermatogenesis and apoptosis, [RefSeq, PubMed]; This gene encodes a member of the heat shock protein 40 co-chaperone family which is produced in large amounts in the testis and is located on the radial spokes of the axoneme in human sperm flagella and other flagellar structures. The encoded protein associates with the sperm annulus, as part of the septin complex, through direct interaction with septin 4, during sperm terminal differentiation. Naturally occurring mutations in this gene are associated with primary ciliary dyskinesia and male infertility. [provided by RefSeq, Apr 2017]., [RefSeq]; This study, which establishes mutations in DNAJB13 as a cause of PCD, unveils the key role played by DNAJB13 in the proper formation and function of ciliary and flagellar axonemes in humans, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3LEP4;Q8IZW5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding",
        "go_cellular_component": "GO:0097229 sperm end piece;GO:0001534 radial spoke;GO:0005829 cytosol;GO:0005929 cilium;GO:0031514 motile cilium",
        "go_biological_process": "GO:1904158 axonemal central apparatus assembly;GO:0030317 flagellated sperm motility;GO:0006457 protein folding;GO:0003341 cilium movement",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "P59910-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q02413-1",
        "uniprot_id": "DSG1_HUMAN",
        "mass": 113748.0,
        "length": 1049,
        "protein_name": "Desmoglein-1",
        "gene_name": "DSG1",
        "organism": "Human",
        "refseq_name": "desmoglein-1 preproprotein",
        "refseq_ac": "NP_001933",
        "gene_names_uniprotkb": "DSG1; CDHF4",
        "gene_names_refseq": "CDHF4; DG1; DSG1; DSG; EPKHE; EPKHIA; PPKS1; SPPK1",
        "protein_names_uniprotkb": "Desmoglein-1; Cadherin family member 4; DG1; DGI; Desmosomal glycoprotein 1; Pemphigus foliaceus antigen",
        "protein_names_refseq": "cadherin family member 4; desmoglein-1 preproprotein; desmosomal glycoprotein 1; pemphigus foliaceus antigen",
        "tax_id": 9606,
        "disease": "alpha-methylacyl-CoA racemase deficiency (Disease Ontology:DOID:0060602); keratosis palmoplantaris striata 1 (Disease Ontology:DOID:0081108); congenital bile acid synthesis defect 4 (Disease Ontology:DOID:0111068); urinary bladder cancer (Disease Ontology:DOID:11054); breast carcinoma (Disease Ontology:DOID:3459); renal cell carcinoma (Disease Ontology:DOID:4450); prostate carcinoma in situ (Disease Ontology:DOID:8634); severe dermatitis-multiple allergies-metabolic wasting syndrome (MONDO:MONDO:0014218)",
        "pathway": " (hsa:1828);  (R-HSA-351906);  (R-HSA-6798695);  (R-HSA-6805567);  (R-HSA-6809371);  (R-HSA-9696264);  (R-HSA-9696270)",
        "pathway_count": 7,
        "publication_count": 149,
        "publication_id_list": "10.1101/2023.09.13.557529;10066784;10196183;10231017;10332028;10411887;10588656;10664463;10748026;10771479;11076937;11350120;11380615;11500511;11590230;11790773;11940653;12093888;12244061;12842009;12902340;14732713;15033990;15054114;15337775;15373777;15738000;15797384;15803139;16061697;16286477;16382671;16481321;16639001;16740002;1691188;1694855;17056584;1711210;1714783;17515931;17521629;17559062;17562024;17596512;1770008;18691976;18843291;18996843;19136556;19190773;19194479;19717567;19759396;20068231;20179351;20657595;20667819;20811643;20940292;21439340;21654840;21997417;22544926;23090970;23481192;23481700;23524970;23629652;23650620;23719902;23974871;2414304;24190977;24220297;24594668;24690281;24715725;25208914;25502872;25888806;25926655;26154972;26374642;26375851;26390218;26604139;26924733;26969432;27452731;28832583;28891468;29242379;29307589;29314611;29393594;30397120;30524438;30833945;31020640;31092671;31154438;31222486;31611695;31844290;31871319;31998317;32157095;32162841;32350084;32373127;32938616;32983136;33043033;33141586;33158670;33537174;33592498;33968037;34019948;34078123;34087483;34171305;34211107;34368962;34561969;34657339;35051231;35154160;35561310;35580925;36241641;36284347;36305887;36495876;37217939;37733372;37938771;38253038;38665916;40596516;7543090;8649376;8692836;8824274;8999895;9395522;9468612;9565599",
        "class_list": "",
        "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:19717567). Promotes differentiation of keratinocytes via interaction with ERBIN. Reduces activation of RAS/ERK signaling pathways in keratinocytes via promoting ERBIN localization to the cell membrane and its interaction with SHOC2, this competitively reduces the formation of RAS-SHOC2 ERK-activating complexes (PubMed:23524970). Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (PubMed:28891468). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (PubMed:28891468). Critical for epidermal integrity and barrier function of the skin (By similarity). Required for esophageal epithelial barrier integrity and correct intercellular spacing in differentiated esophageal epithelium (PubMed:24220297). Required for recovery of epidermal architecture and correct expression of differentiation markers following UVB exposure (PubMed:24594668). May also be required for OCLN involvement in tight junctions (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; DSG1 deficiency was associated with increased expression of a number of genes encoding allergy-related cytokines, [RefSeq, PubMed]; Epidermal stratification requires retromer-mediated desmoglein-1 recycling., [RefSeq, PubMed]; Melanoma cells repress Desmoglein 1 in keratinocytes to promote tumor cell migration., [RefSeq, PubMed]; This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]., [RefSeq]; Two cases of Hallopeau-type pemphigus vegetans with anti-desmoglein 1 and anti-desmocollin 3 antibodies without mucosal involvement., [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 42,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 8,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z845",
        "ec_number_list": "",
        "go_molecular_function": "GO:0015643 toxic substance binding;GO:0005509 calcium ion binding;GO:0045295 gamma-catenin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0032570 response to progesterone;GO:0050821 protein stabilization;GO:0060135 maternal process involved in female pregnancy;GO:0007043 cell-cell junction assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 15.5,
        "record_id": "Q02413-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q09013-9",
        "uniprot_id": "DMPK_HUMAN",
        "mass": 69385.0,
        "length": 629,
        "protein_name": "Myotonin-protein kinase",
        "gene_name": "DMPK",
        "organism": "Human",
        "refseq_name": "myotonin-protein kinase isoform 3",
        "refseq_ac": "NP_001075029",
        "gene_names_uniprotkb": "DMPK; DM1PK; MDPK",
        "gene_names_refseq": "DM1PK; DM1; DMK; DMPK; DM; MDPK; MT-PK",
        "protein_names_uniprotkb": "Myotonin-protein kinase; 2.7.11.1; DM-kinase; DM1 protein kinase; DMK; DMPK; MT-PK; Myotonic dystrophy protein kinase",
        "protein_names_refseq": "DM protein kinase; dystrophia myotonica protein kinase; myotonic dystrophy associated protein kinase; myotonin protein kinase A; myotonin-protein kinase isoform 3; thymopoietin homolog",
        "tax_id": 9606,
        "disease": "spinocerebellar ataxia 15 (Disease Ontology:DOID:0050965); spinocerebellar ataxia 29 (Disease Ontology:DOID:0050978); cardiac arrest (Disease Ontology:DOID:0060319); Gillespie syndrome (Disease Ontology:DOID:0111578); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); gestational diabetes (Disease Ontology:DOID:11714); myotonic dystrophy type 1 (Disease Ontology:DOID:11722); Huntington's disease (Disease Ontology:DOID:12858); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441); congenital heart disease (Disease Ontology:DOID:1682); transient cerebral ischemia (Disease Ontology:DOID:224); asthma (Disease Ontology:DOID:2841); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:1760);  (R-HSA-5578775)",
        "pathway_count": 2,
        "publication_count": 82,
        "publication_id_list": "10220561;10699184;10811636;10869570;10913253;11062458;11287000;11904675;12119109;12832055;12953268;1302022;1310900;15174025;15260953;1546326;15583383;15598648;15684391;15754088;16754674;16770013;1693919;17224452;17344846;17357072;17486119;18995841;19278978;19309729;19514047;19751721;20388710;20843780;21108950;21457715;21949239;22210847;2226863;22427649;22707725;22972900;23362265;23549614;23610579;2430951;24722188;2477373;2559024;25994790;2838329;28645727;2953725;29557506;31154438;31844290;32157095;32938616;33497365;33968037;34171305;34561969;34776509;35051231;35054778;35741732;36241641;36284347;36883684;39894887;6328127;7488138;7702581;7905855;7929371;8076686;8469976;8499920;8798450;8918259;9346285;9490724",
        "class_list": "",
        "function": "DM1 Transgenic Mice Exhibit Abnormal Neurotransmitter Homeostasis and Synaptic Plasticity in Association with RNA Foci and Mis-Splicing in the Hippocampus. Publication Status: Online-Only, [RefSeq, PubMed]; DMPK hypermethylation in sperm cells of myotonic dystrophy type 1 patients., [RefSeq, PubMed]; Diaphragmatic hernia in a term newborn with congenital myotonic dystrophy: case report. Publication Status: Online-Only, [RefSeq, PubMed]; High Resolution Analysis of DMPK Hypermethylation and Repeat Interruptions in Myotonic Dystrophy Type 1. Publication Status: Online-Only, [RefSeq, PubMed]; Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Reversible cardiac disease features in an inducible CUG repeat RNA-expressing mouse model of myotonic dystrophy. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 14,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E5KR08;Q16205;Q6P5Z6",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0017020 myosin phosphatase regulator activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0010657 muscle cell apoptotic process;GO:0010830 regulation of myotube differentiation;GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling;GO:0006468 protein phosphorylation;GO:0006874 intracellular calcium ion homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "Q09013-9",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q12882-1",
        "uniprot_id": "DPYD_HUMAN",
        "mass": 111401.0,
        "length": 1025,
        "protein_name": "Dihydropyrimidine dehydrogenase [NADP(+)]",
        "gene_name": "DPYD",
        "organism": "Human",
        "refseq_name": "dihydropyrimidine dehydrogenase [NADP(+)] isoform 1",
        "refseq_ac": "NP_000101",
        "gene_names_uniprotkb": "DPYD",
        "gene_names_refseq": "DHPDHASE; DHP; DPD; DPYD; DYPD",
        "protein_names_uniprotkb": "Dihydropyrimidine dehydrogenase [NADP(+)]; 1.3.1.2; DHPDHase; DPD; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase",
        "protein_names_refseq": "dihydropyrimidine dehydrogenase [NADP(+)] isoform 1; dihydrothymine dehydrogenase; dihydrouracil dehydrogenase",
        "tax_id": 9606,
        "disease": "brain cancer (Disease Ontology:DOID:1319); dihydropyrimidine dehydrogenase deficiency (Disease Ontology:DOID:14218); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); kidney cancer (Disease Ontology:DOID:263); carcinoma (Disease Ontology:DOID:305); gallbladder cancer (Disease Ontology:DOID:3121); liver disease (Disease Ontology:DOID:409); neuroblastoma (Disease Ontology:DOID:769); colorectal cancer (Disease Ontology:DOID:9256); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)",
        "pathway": " (hsa:1806);  (R-HSA-73621)",
        "pathway_count": 2,
        "publication_count": 110,
        "publication_id_list": "10364222;10681516;10899995;10989446;11083867;11133996;12124385;12352955;12849978;12947102;14725767;1512248;15385443;1590793;16377327;18987736;19291308;19608861;20018850;2129526;2157703;23186163;2344353;23481700;24714562;24715725;25418920;25576301;25645385;25880248;26154972;26375851;26992070;27846572;27862975;27920218;28218747;28228285;2826576;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29786170;29789417;30315122;30379171;30410026;30429286;30833945;31154438;31222486;31492838;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33298915;33392160;33592498;33912179;33936100;33968037;33981976;34171305;34185709;34357683;34932366;35051231;35154160;35254053;35318648;35561310;35580925;35705054;36010968;36241641;36284347;37938771;38686795;38709992;38886557;39126072;40307207;7284378;7488099;8083224;8892022;9135003;9170156;9266349;9439663;9464498;9472650;9718352;9723824",
        "class_list": "",
        "function": "DPYD genetic polymorphisms in non-European patients with severe fluoropyrimidine-related toxicity: a systematic review., [RefSeq, PubMed]; Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD). Publication Status: Online-Only, [RefSeq, PubMed]; Involved in pyrimidine base degradation (PubMed:1512248). Catalyzes the reduction of uracil and thymine (PubMed:1512248). Also involved the degradation of the chemotherapeutic drug 5-fluorouracil (PubMed:1512248)., [UniProtKB, PubMed]; Lethal Capecitabine Toxicity in Patients With Complete Dihydropyrimidine Dehydrogenase Deficiency Due to Ultra-Rare DPYD Variants., [RefSeq, PubMed]; MIR27A Gene Polymorphism Modifies the Effect of Common DPYD Gene Variants on Severe Toxicity in Patients with Gastrointestinal Tumors Treated with Fluoropyrimidine-Based Anticancer Therapy. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 63,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 11,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RRQ2;A2RRQ3;A8K5A2;A8MWG9;B1AN21;E9PFN1;Q16694;Q16761;Q32NB0;Q96HL6;Q96TH1",
        "ec_number_list": "1.3.1.2",
        "go_molecular_function": "GO:0002058 uracil binding;GO:0017113 dihydropyrimidine dehydrogenase (NADP+) activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0050660 flavin adenine dinucleotide binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0046079 dUMP catabolic process;GO:0006145 purine nucleobase catabolic process;GO:0006208 pyrimidine nucleobase catabolic process;GO:0006210 thymine catabolic process;GO:0006212 uracil catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 11.6,
        "record_id": "Q12882-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13202-1",
        "uniprot_id": "DUS8_HUMAN",
        "mass": 65827.0,
        "length": 625,
        "protein_name": "Dual specificity protein phosphatase 8",
        "gene_name": "DUSP8",
        "organism": "Human",
        "refseq_name": "dual specificity protein phosphatase 8",
        "refseq_ac": "NP_004411",
        "gene_names_uniprotkb": "DUSP8; C11orf81; VH5",
        "gene_names_refseq": "C11orf81; DUSP8; HB5; HVH-5; HVH8",
        "protein_names_uniprotkb": "Dual specificity protein phosphatase 8; 3.1.3.16; 3.1.3.48; Dual specificity protein phosphatase hVH-5",
        "protein_names_refseq": "H1 phosphatase, vaccinia virus homolog; dual specificity protein phosphatase 8; dual specificity protein phosphatase hVH-5; serine/threonine specific protein phosphatase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:1850);  (R-HSA-112409);  (R-HSA-5675221);  (R-HSA-9652817)",
        "pathway_count": 4,
        "publication_count": 45,
        "publication_id_list": "10206983;10415025;10490027;10702794;10757792;12583813;13129832;14724641;15664191;15851477;15899389;16892053;17097642;17208316;17724343;18294816;18332145;18515281;18547165;19091743;19158341;20332238;20463170;21779496;22569528;22730326;23105109;24390348;24531476;25314968;25597358;25631445;27760319;28121444;29242379;31154438;31844290;33131190;33981976;35051231;35428675;36241641;37909329;38396293;7561881",
        "class_list": "",
        "function": "Because this variant of hVH-5 lacked intronic sequences in its genomic structure, we suggest it might be a processed pseudogene of hVH-5., [RefSeq, PubMed]; DUSP8 induces TGF-beta-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-alpha. Publication Status: Online-Only, [RefSeq, PubMed]; DUSP8 is genetically linked to alcohol dependence and was found on chromosome 11p15.5, [RefSeq, PubMed]; Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans., [RefSeq, PubMed]; Dual-specificity phosphatase 8 (DUSP8) induces drug resistance in breast cancer by regulating MAPK pathways., [RefSeq, PubMed]; Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues., [UniProtKB, UniProtKB]; MiR-147b mediated suppression of DUSP8 promotes lung cancer progression., [RefSeq, PubMed]; The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86SS8",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.21;3.1.3.18;3.1.3.-;3.1.3.5;3.1.3.2;2.7.11.24;2.7.10.1;3.1.3.67;3.1.3.53;3.1.3.52;3.1.3.27;3.1.3.86;3.1.3.36;3.1.3.74",
        "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0016791 phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity;GO:0033550 MAP kinase tyrosine phosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0016311 dephosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.6,
        "record_id": "Q13202-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13316-1",
        "uniprot_id": "DMP1_HUMAN",
        "mass": 55782.0,
        "length": 513,
        "protein_name": "Dentin matrix acidic phosphoprotein 1",
        "gene_name": "DMP1",
        "organism": "Human",
        "refseq_name": "dentin matrix acidic phosphoprotein 1 isoform 2 precursor",
        "refseq_ac": "NP_001073380",
        "gene_names_uniprotkb": "DMP1",
        "gene_names_refseq": "ARHP; ARHR; DMP-1; DMP1",
        "protein_names_uniprotkb": "Dentin matrix acidic phosphoprotein 1; DMP-1; Dentin matrix protein 1",
        "protein_names_refseq": "dentin matrix acidic phosphoprotein 1 isoform 2 precursor; dentin matrix protein 1",
        "tax_id": 9606,
        "disease": "autosomal recessive hypophosphatemic rickets (Disease Ontology:DOID:0050949)",
        "pathway": " (hsa:1758);  (R-HSA-3000178);  (R-HSA-381426);  (R-HSA-8957275)",
        "pathway_count": 4,
        "publication_count": 115,
        "publication_id_list": "10022829;10026136;10077652;10218588;10339611;10512690;10614670;10673326;10681634;10810289;10898936;10912521;10951195;10990447;11084047;11158056;11237011;11250653;11259413;11264294;11316783;11522292;11606061;11739083;11751371;11788658;11825898;12225811;12241545;12379487;12466191;12615915;12810533;12904166;1370451;1376317;1383255;14715956;15075323;15126567;15296743;15308688;1544908;15469690;15485880;15525596;15642270;16293224;16493581;17033621;17033625;17047378;17249697;17312271;17588949;17985932;2059554;21642437;21789315;22134916;22582013;2364322;2412224;2420006;2430969;24715725;2476804;2479552;26091039;29557506;33420898;35981698;36315908;36482408;6193777;6439184;7499434;7519608;7523391;7525263;7525634;7525824;7527058;7527330;7538844;7542669;7543116;7559467;7588299;7683646;7685013;7689487;7693733;7852349;8002934;8440685;8586437;8781553;8798654;8817670;8894645;8943283;8964575;9177774;9252349;9294172;9341124;9346959;9497324;9685393;9709957;9733769;9786878;9922210;9949188",
        "class_list": "",
        "function": "DMP-1 promoter-associated antisense strand non-coding RNA, panRNA-DMP-1, physically associates with EGFR to repress EGF-induced squamous cell carcinoma migration., [RefSeq, PubMed]; Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; First report in Argentina of a pathogenic DMP1 variant associated with autosomal recessive hypophosphatemic rickets., [RefSeq, PubMed]; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite., [UniProtKB, PubMed]; Mettl3 regulates hypertrophic differentiation of chondrocytes through modulating Dmp1 mRNA via Ythdf1-mediated m(6)A modification., [RefSeq, PubMed]; Three SIBLINGs (small integrin-binding ligand, N-linked glycoproteins) enhance factor H's cofactor activity enabling MCP-like cellular evasion of complement-mediated attack., [RefSeq, PubMed]; Whole exome sequencing identifies two novel variants in PHEX and DMP1 in Malaysian children with hypophosphatemic rickets. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 9,
        "predicted_n_glycosites": 8,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 53,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L4L3;O43265",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005178 integrin binding;GO:0005509 calcium ion binding;GO:0050840 extracellular matrix binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005788 endoplasmic reticulum lumen;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0031214 biomineral tissue development;GO:0001503 ossification",
        "synthesized_glycan_count": 0,
        "hit_score": 11.6,
        "record_id": "Q13316-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13474-1",
        "uniprot_id": "DRP2_HUMAN",
        "mass": 107962.0,
        "length": 957,
        "protein_name": "Dystrophin-related protein 2",
        "gene_name": "DRP2",
        "organism": "Human",
        "refseq_name": "dystrophin-related protein 2 isoform 2",
        "refseq_ac": "NP_001164655",
        "gene_names_uniprotkb": "DRP2",
        "gene_names_refseq": "DRP-2; DRP2",
        "protein_names_uniprotkb": "Dystrophin-related protein 2; DRP-2",
        "protein_names_refseq": "dystrophin-related protein 2 isoform 2",
        "tax_id": 9606,
        "disease": "pre-malignant neoplasm (Disease Ontology:DOID:0060071); Loeys-Dietz syndrome 3 (Disease Ontology:DOID:0070237); prostate cancer (Disease Ontology:DOID:10283); hypospadias (Disease Ontology:DOID:10892); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); alcoholic cardiomyopathy (Disease Ontology:DOID:12935); endometrial cancer (Disease Ontology:DOID:1380); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); pancreatic cancer (Disease Ontology:DOID:1793); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); Lynch syndrome (Disease Ontology:DOID:3883); lung non-small cell carcinoma (Disease Ontology:DOID:3908); osteoarthritis (Disease Ontology:DOID:8398); muscular dystrophy (Disease Ontology:DOID:9884); cocaine dependence (Disease Ontology:DOID:9975)",
        "pathway": " (hsa:1821);  (R-HSA-9619665);  (R-HSA-9913351)",
        "pathway_count": 3,
        "publication_count": 143,
        "publication_id_list": "10022829;10189375;10203854;10220111;10400691;10441321;10545507;10727776;10757804;10856243;10893187;10932245;10942431;11115854;11133365;11157804;11237011;11352924;11356866;11394999;11430795;11430802;11495720;11734543;11782409;12056842;12145339;12189167;12198163;12782656;12799134;1319059;14512514;14522948;14664827;15150276;15175026;15189448;15356632;15610069;15695336;15836632;15907797;16136673;16311519;16319321;16373334;16524571;16923174;1704008;17325040;17699610;17905726;17959798;18634568;18764929;18803322;19143832;19156870;19321787;19346169;19745155;1975954;19922439;19946898;20044576;20149798;20213556;20625412;20832498;21044070;21326363;21411665;21423190;21423191;21613327;21653862;22053691;22159078;22180461;22223806;22333914;22492709;22764250;22814607;23695165;23747866;23874858;23999528;24191038;24227709;24646194;24675079;24715725;25974668;26423937;26441514;27220739;27288457;27859941;28852375;29557506;29748249;29786170;31844290;32387766;3282674;32938616;34561969;35051231;36215666;36240223;38513194;7527495;7547961;7592992;7844150;7925941;7935840;8043271;8138712;8268918;8349731;8576247;8607994;8619637;8627307;8640231;8647822;8662541;8798547;8842374;8845841;9214383;9405466;9412493;9418958;9482253;9652404;9705348;9748295;9858769;9864373",
        "class_list": "",
        "function": "Among the genes found disrupted in this study, there is evidence suggesting that YWHAZ and also the X-linked DRP2 may be considered as novel autism candidate genes., [RefSeq, PubMed]; Expanding the Clinical Spectrum of DRP2-Associated Charcot-Marie-Tooth Disease., [RefSeq, PubMed]; Members of the dystrophin family of proteins perform a critical role in the maintenance of membrane-associated complexes at points of intercellular contact in vertebrate cells. The protein encoded by this gene is predicted to resemble certain short C-terminal isoforms of dystrophin and dystrophin-related protein 1 (DRP1 or utrophin). DRP2 is expressed principally in the brain and spinal cord. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]., [RefSeq]; Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 15,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6ZKI5;A8K1B0;B1B1F3;B4DIZ0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0043204 perikaryon",
        "go_biological_process": "GO:0050808 synapse organization;GO:0007417 central nervous system development;GO:0099536 synaptic signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 14.9,
        "record_id": "Q13474-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q155Q3-1",
        "uniprot_id": "DIXC1_HUMAN",
        "mass": 77478.0,
        "length": 683,
        "protein_name": "Dixin",
        "gene_name": "DIXDC1",
        "organism": "Human",
        "refseq_name": "dixin isoform a",
        "refseq_ac": "NP_001033043",
        "gene_names_uniprotkb": "DIXDC1; CCD1; KIAA1735",
        "gene_names_refseq": "CCD1; DIXDC1",
        "protein_names_uniprotkb": "Dixin; Coiled-coil protein DIX1; Coiled-coil-DIX1; DIX domain-containing protein 1",
        "protein_names_refseq": "coiled-coil protein DIX1; dixin isoform a; dixin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:85458)",
        "pathway_count": 1,
        "publication_count": 22,
        "publication_id_list": "11237011;12792787;15262978;16814745;18629627;18669648;19375513;20068231;20085589;20213681;21189423;24275569;29242379;30429286;32387766;32495922;32938616;33592498;34087483;34898351;35051231;35580925",
        "class_list": "",
        "function": "Ccd1 inhibits Axin-mediated JNK activation by simultaneously adopting two distinct mechanisms, one through conformational changes that disallow MEKK1 binding and the other via direct sequestration of MEKK4., [RefSeq, PubMed]; Circular RNA circ_0000423 promotes gastric cancer cell proliferation, migration and invasion via the microR-582-3p/Disheveled-Axin domain containing 1 axis., [RefSeq, PubMed]; DIXDC1 might play an important role during neurogenesis, overexpression of DIXDC1 in embryonic carcinoma P19 cells promoted neuronal differentiation, and inhibited gliogenesis induced by retinoic acid., [RefSeq, PubMed]; KIAA1735 maps to human chromosome 11q23.1 and encodes a novel protein with a myosine-tail homologous domain and C-terminal DIX domain GeneRIF: MTHDIX (KIAA1735) protein consists of Myosine-tail homologous (MTH) domain and C-terminal DIX domain., [RefSeq, PubMed]; LncRNA SNHG20 enhances the progression of oral squamous cell carcinoma by regulating the miR-29a/DIXDC1/Wnt regulatory axis., [RefSeq, PubMed]; Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2., [UniProtKB, PubMed, PubMed]; The GFP-tag fused DIXDC1 exogenously expressed co-localize with gamma-tubulin both at interphase and mitotic phase in the centrosomes., [RefSeq, PubMed]; The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]., [RefSeq]; Thus, our data provide the first evidence that l-DIXDC1 may act as a novel branching component in the Wnt signaling pathway targeting both beta-catenin-TCF complex for gene expression and cytoskeleton for regulating dynamics of actin filaments., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1A5D8;E9PRV4;Q6P2J8;Q6PIK4;Q86SR7;Q8IVY4;Q96N69;Q9C0C8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0019904 protein domain specific binding;GO:0043015 gamma-tubulin binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0098794 postsynapse;GO:0001725 stress fiber",
        "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0021799 cerebral cortex radially oriented cell migration;GO:0021869 forebrain ventricular zone progenitor cell division;GO:0032956 regulation of actin cytoskeleton organization;GO:0045665 negative regulation of neuron differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q155Q3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q16555-1",
        "uniprot_id": "DPYL2_HUMAN",
        "mass": 62294.0,
        "length": 572,
        "protein_name": "Dihydropyrimidinase-related protein 2",
        "gene_name": "DPYSL2",
        "organism": "Human",
        "refseq_name": "dihydropyrimidinase-related protein 2 isoform 1",
        "refseq_ac": "NP_001184222",
        "gene_names_uniprotkb": "DPYSL2; CRMP2; ULIP2",
        "gene_names_refseq": "CRMP-2; CRMP2; DHPRP2; DPYSL2; DRP-2; DRP2; N2A3; ULIP-2; ULIP2",
        "protein_names_uniprotkb": "Dihydropyrimidinase-related protein 2; CRMP-2; Collapsin response mediator protein 2; DRP-2; N2A3; ULIP-2; Unc-33-like phosphoprotein 2",
        "protein_names_refseq": "collapsin response mediator protein hCRMP-2; dihydropyrimidinase-related protein 2 isoform 1; dihydropyrimidinase-related protein 2; unc-33-like phosphoprotein 2",
        "tax_id": 9606,
        "disease": "hypothyroidism (Disease Ontology:DOID:1459); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316)",
        "pathway": " (hsa:1808);  (R-HSA-399956);  (R-HSA-437239)",
        "pathway_count": 3,
        "publication_count": 171,
        "publication_id_list": "10.1101/2023.09.13.557529;10574455;10608864;10747093;10757975;10804209;10818093;10818153;11237011;11477421;12082080;12093729;12372285;12942088;14685275;15466863;15483118;15652488;15676027;16190365;16260607;16330023;16595691;16611631;16959974;16964243;17250651;17322306;17607942;17607944;17902168;18212344;18478542;18491316;18669648;18767875;19235893;19278660;19413330;19415658;19531498;19651622;19652227;19664994;19664995;20068231;20166139;20801876;20831597;21406692;22905912;23023514;23186163;23481700;24366607;2448316;24715725;24904280;25040932;25104922;25147500;25418920;25505266;25576301;25645385;25880248;25995380;26375851;26389656;26555036;26804001;26952865;27397612;27452731;27543614;27609071;27726376;27846572;27862975;28218747;28228285;28510447;28514659;28649982;28657654;28808029;28832583;28855257;28904123;29066950;29242379;29393594;29396402;29437277;29493099;29508533;29557506;29632046;29632711;29786170;29789417;29926835;30315122;30397120;30429286;30484775;30524438;30816227;30833945;31020640;31024297;31154438;31217245;31373491;31561361;31637018;31844290;31848261;32094324;32157095;32161166;32162841;32350084;32357974;32387766;32502341;32778769;32897882;32938616;32983136;33043033;33214551;33298915;33401710;33592498;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34229054;34725712;34931806;34975828;35051231;35132862;35251023;35580925;35705054;36010968;36215666;36241641;36284347;37074911;37217939;37479784;37938771;38583951;38665916;38830696;40307207;40596516;40914422;7493978;7637782;8973361;9651214;9721721",
        "class_list": "",
        "function": "DPYSL2/CRMP2 isoform B knockout in human iPSC-derived glutamatergic neurons confirms its role in mTOR signaling and neurodevelopmental disorders., [RefSeq, PubMed]; Forebrain commissure formation in zebrafish embryo requires the binding of KLC1 to CRMP2., [RefSeq, PubMed]; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]., [RefSeq]; Zinc Deficiency Decreases Neurite Extension via CRMP2 Signal Pathway., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 8,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 8,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 9,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 26,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 34,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 3,
        "glyco_site_count": 13,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5H2;B4DR31;D3DSS7;O00424",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004157 dihydropyrimidinase activity;GO:0042802 identical protein binding;GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0019901 protein kinase binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge",
        "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0007010 cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 18.8,
        "record_id": "Q16555-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q16854-1",
        "uniprot_id": "DGUOK_HUMAN",
        "mass": 32056.0,
        "length": 277,
        "protein_name": "Deoxyguanosine kinase, mitochondrial",
        "gene_name": "DGUOK",
        "organism": "Human",
        "refseq_name": "deoxyguanosine kinase, mitochondrial isoform c precursor",
        "refseq_ac": "NP_001305788",
        "gene_names_uniprotkb": "DGUOK; DGK",
        "gene_names_refseq": "DGUOK; MTDPS3; NCPH1; NCPH; PEOB4; dGK",
        "protein_names_uniprotkb": "Deoxyguanosine kinase, mitochondrial; 2.7.1.113; 2.7.1.76; Deoxyadenosine kinase, mitochondrial",
        "protein_names_refseq": "deoxyadenosine kinase, mitochondrial; deoxyguanosine kinase, mitochondrial isoform c precursor; deoxyguanosine kinase, mitochondrial",
        "tax_id": 9606,
        "disease": "mitochondrial DNA depletion syndrome 3 (Disease Ontology:DOID:0080121); autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4 (Disease Ontology:DOID:0111516); portal hypertension (Disease Ontology:DOID:10762); cholestasis (Disease Ontology:DOID:13580); primary pulmonary hypertension (Disease Ontology:DOID:14557); glaucoma (Disease Ontology:DOID:1686); pulmonary hypertension (Disease Ontology:DOID:6432); mitochondrial metabolism disease (Disease Ontology:DOID:700); portal hypertension, noncirrhotic, 1 (MONDO:MONDO:8000013)",
        "pathway": " (hsa:1716);  (R-HSA-74217)",
        "pathway_count": 2,
        "publication_count": 76,
        "publication_id_list": "11427893;11687801;12009299;12205643;1429593;15639197;16359702;17073823;18399692;19608861;2104852;21755941;218932;227870;23043144;23481700;2539852;25418920;25576301;25645385;25880248;26874653;26992070;28218747;28228285;2844225;2845866;28493820;28514659;28832583;28834231;29242379;29437277;29493099;29508533;29557506;2999129;3029074;30315122;30429286;30779550;31154438;31217245;3182793;31844290;31848261;32144205;32157095;32357974;32387766;32938616;32983136;33141586;33298915;33392160;33592498;33912179;33968037;34185709;34357683;34561969;34932366;35051231;35580925;36010968;38027095;40307207;457664;6281270;6300847;6771276;8692979;8706825;9804782;9843365;9857047",
        "class_list": "",
        "function": "Case report: Two unexpected cases of DGUOK-related mitochondrial DNA depletion syndrome presenting with hyperinsulinemic hypoglycemia. Publication Status: Online-Only, [RefSeq, PubMed]; DGUOK deficiency and mutation is associated with mitochondrial DNA depletion syndromes., [RefSeq, PubMed]; In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine (PubMed:11687801, PubMed:17073823, PubMed:23043144, PubMed:8692979, PubMed:8706825). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (By similarity). Widely used as target of antiviral and chemotherapeutic agents., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 9,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P78532;Q16759;Q4ZG09;Q7L1W9;Q96BC1",
        "ec_number_list": "2.7.1.113;2.7.1.76;2.7.1.74",
        "go_molecular_function": "GO:0004138 deoxyguanosine kinase activity;GO:0005524 ATP binding;GO:0004136 deoxyadenosine kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol",
        "go_biological_process": "GO:0008617 guanosine metabolic process;GO:0046122 purine deoxyribonucleoside metabolic process;GO:0010977 negative regulation of neuron projection development;GO:0042775 mitochondrial ATP synthesis coupled electron transport;GO:0106383 dAMP salvage",
        "synthesized_glycan_count": 0,
        "hit_score": 7.9,
        "record_id": "Q16854-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q30154-1",
        "uniprot_id": "DRB5_HUMAN",
        "mass": 30056.0,
        "length": 266,
        "protein_name": "HLA class II histocompatibility antigen, DR beta 5 chain",
        "gene_name": "HLA-DRB5",
        "organism": "Human",
        "refseq_name": "major histocompatibility complex, class II, DR beta 5 precursor",
        "refseq_ac": "NP_002116",
        "gene_names_uniprotkb": "HLA-DRB5",
        "gene_names_refseq": "DRB5; HLA-DRB5*; HLA-DRB5",
        "protein_names_uniprotkb": "HLA class II histocompatibility antigen, DR beta 5 chain; DR beta-5; DR2-beta-2; Dw2; MHC class II antigen DRB5",
        "protein_names_refseq": "DR beta-5; HLA class II histocompatibility antigen, DR-5 beta chain; MHC class II antigen DRB5; major histocompatibility complex, class II, DR beta 5 precursor",
        "tax_id": 9606,
        "disease": "Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); acute disseminated encephalomyelitis (Disease Ontology:DOID:639)",
        "pathway": " (hsa:3127);  (R-HSA-202424);  (R-HSA-202427);  (R-HSA-202430);  (R-HSA-202433);  (R-HSA-2132295);  (R-HSA-389948);  (R-HSA-877300)",
        "pathway_count": 8,
        "publication_count": 254,
        "publication_id_list": "10.1101/2023.09.13.557529;10036229;10064083;10067896;10072072;10480952;10540230;10593899;10631941;10631952;10639150;10671560;10698680;10716940;10747096;10748235;10790433;10809954;10811803;10986460;11048639;11080454;11163233;11237011;11358993;11390650;11529500;11607830;11684289;11752630;11790530;11813165;11827988;11853874;11884229;11972023;12040185;12078484;12198549;12244309;12438563;12446674;12473184;12485116;12660731;12742663;12748383;12893276;12915721;12938237;12947224;1396683;1399720;14510693;14514672;14586410;14617041;1471145;14722222;14731593;15084594;1508672;15122200;15125833;15143187;15145317;15322115;15358536;15371334;15388922;15489910;15489916;15530433;15541657;15749704;15911768;16056267;16079912;16181339;16237089;16242130;16356853;16356855;16364187;16461343;16467876;16612002;16618111;16671952;16824007;16978534;17047224;17072321;17125875;17135271;17142755;17241953;17283181;17363905;17468049;17496917;17548359;17652306;17728323;18046453;18173375;18292509;18305173;18362138;18591661;18759926;19092054;19159218;19533806;1956401;19564404;2001975;20049711;20130243;20304997;20346773;20363976;21116285;21154117;2121367;21441454;21543337;2190094;22426112;23061660;23302904;23580664;23739916;2391366;24190977;24417533;24714562;2530588;25645385;26375851;26992070;27726376;27846572;27862975;28165004;28265006;28467828;2885840;29493099;29557506;29632711;29741879;29863979;30522017;3099214;31313098;31611695;31844290;31882398;32157095;32162841;32350084;32387766;32502341;3259543;32938616;32983136;33043033;33091337;33141586;33239784;33392160;33592498;33633747;33717175;33912179;33936100;33968037;34087483;34357683;34433824;3476943;35051231;35154160;3571980;36215666;36284347;36658707;37074911;37688529;38104778;6576979;7479848;7481823;7510216;7514165;7530745;7565724;7592972;7615558;7617032;7650016;7657660;7667286;7673114;7690989;7796299;8046351;8134367;8145819;8148318;8156998;8176225;8313912;8397411;8415765;8483949;8520027;8530158;8550590;8550631;8598037;8601309;8631301;8642258;8687433;8773325;8798379;8824201;8849454;8909537;8939989;8947036;9075930;9111318;9115214;9143706;9162096;9202021;9226128;9252186;9311912;9312039;9362451;9458128;9497313;9539769;9545226;9606180;9687533;9694360;9846482;9850860;9990853",
        "class_list": "",
        "function": "Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading., [UniProtKB]; Epigenome-wide methylation haplotype association analysis identified HLA-DRB1, HLA-DRB5 and HLA-DQB1 as risk factors for rheumatoid arthritis., [RefSeq, PubMed]; HLA DRB5 *01:01 is associated with pruritus in individuals with Fitzpatrick skin type IV-VI., [RefSeq, PubMed]; HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020]., [RefSeq]; Increased HLA-DR expression and cortical demyelination in MS links with HLA-DR15. Publication Status: Online-Only, [RefSeq, PubMed]; Whole Exome Sequencing Identified Two Single Nucleotide Polymorphisms of Human Leukocyte Antigen-DRB5 in Familial Sarcoidosis in China., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 8796,
        "biomarker_type": "",
        "glycan_count": 40,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RBV6;C7C4X3;O00157;O00283;O46700;Q29703;Q29787;Q29788;Q30126;Q30150;Q30199;Q6SJR2;Q7M2H9;Q8HWS7;Q8WLR5;Q9MY54;Q9XRX6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane;GO:0070062 extracellular exosome;GO:0005765 lysosomal membrane",
        "go_biological_process": "GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0002250 adaptive immune response;GO:0050870 positive regulation of T cell activation;GO:0050778 positive regulation of immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 29.6,
        "record_id": "Q30154-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5HYR2-1",
        "uniprot_id": "DMRTC_HUMAN",
        "mass": 20139.0,
        "length": 192,
        "protein_name": "Doublesex- and mab-3-related transcription factor C1",
        "gene_name": "DMRTC1B; DMRTC1",
        "organism": "Human",
        "refseq_name": "doublesex- and mab-3-related transcription factor C1 isoform 1",
        "refseq_ac": "NP_001074320",
        "gene_names_uniprotkb": "DMRTC1B; DMRTC1; DMRTC1B",
        "gene_names_refseq": "DMRTC1B",
        "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor C1",
        "protein_names_refseq": "DMRT-like family C1; doublesex- and mab-3-related transcription factor C1 isoform 1; doublesex- and mab-3-related transcription factor C1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:63947);  (hsa:728656)",
        "pathway_count": 2,
        "publication_count": 3,
        "publication_id_list": "11237011;11863363;24715725",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5HYR0;Q5U5K2;Q8N6L3;Q96SD3",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q5HYR2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5T2R2-1",
        "uniprot_id": "DPS1_HUMAN",
        "mass": 46261.0,
        "length": 415,
        "protein_name": "All trans-polyprenyl-diphosphate synthase PDSS1",
        "gene_name": "PDSS1",
        "organism": "Human",
        "refseq_name": "all trans-polyprenyl-diphosphate synthase PDSS1 isoform 2",
        "refseq_ac": "NP_001308907",
        "gene_names_uniprotkb": "PDSS1; DPS1; TPRT",
        "gene_names_refseq": "COQ10D2; COQ1A; COQ1; DPS; PDSS1; SPS; TPRT; TPT 1; TPT; hDPS1",
        "protein_names_uniprotkb": "All trans-polyprenyl-diphosphate synthase PDSS1; 2.5.1.91; All-trans-decaprenyl-diphosphate synthase subunit 1; Decaprenyl pyrophosphate synthase subunit 1; Decaprenyl-diphosphate synthase subunit 1; Solanesyl-diphosphate synthase subunit 1; TPT 1; Trans-prenyltransferase 1",
        "protein_names_refseq": "all trans-polyprenyl-diphosphate synthase PDSS1 isoform 2; all trans-polyprenyl-diphosphate synthase PDSS1; all-trans-decaprenyl-diphosphate synthase subunit 1; coenzyme Q1 homolog; decaprenyl pyrophosphate synthase subunit 1; polyprenyl pyrophosphate synthetase; prenyl (decaprenyl) diphosphate synthase, subunit 1; solanesyl-diphosphate synthase subunit 1; subunit 1 of decaprenyl diphosphate synthase; trans-prenyltransferase (TPT); trans-prenyltransferase 1",
        "tax_id": 9606,
        "disease": "primary coenzyme Q10 deficiency 2 (Disease Ontology:DOID:0070239)",
        "pathway": " (hsa:23590);  (R-HSA-2142789)",
        "pathway_count": 2,
        "publication_count": 47,
        "publication_id_list": "10501970;10777520;10972372;11237011;12721307;15153069;16262699;16624818;17332895;17374725;17916383;21540551;21944752;23354120;24270420;24714562;25152161;25339443;25892735;26728094;27155576;27499296;28832583;28904123;29242379;29557506;29769354;29789417;31217245;31844290;32157095;32232919;32707086;32983136;33285023;33298915;33912179;33936100;34408002;34471290;34800366;36306796;36581221;36658222;38425362;8621692;9083049",
        "class_list": "",
        "function": "Genetic variants in PDSS1 and SLC16A6 of the ketone body metabolic pathway predict cutaneous melanoma-specific survival., [RefSeq, PubMed]; Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone (PubMed:16262699). Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9)and ubiquinone-10 (Q10) respectively (PubMed:16262699). The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry (PubMed:16262699)., [UniProtKB, PubMed]; Missense PDSS1 mutations in CoenzymeQ10 synthesis cause optic atrophy and sensorineural deafness., [RefSeq, PubMed]; PDSS1-Mediated Activation of CAMK2A-STAT3 Signaling Promotes Metastasis in Triple-Negative Breast Cancer., [RefSeq, PubMed]; The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in this gene are a cause of coenzyme Q10 deficiency. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53F75;Q6P473;Q86WQ8;Q9Y2W5",
        "ec_number_list": "2.5.1.91",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0004659 prenyltransferase activity;GO:0097269 all-trans-decaprenyl-diphosphate synthase activity;GO:0052923 all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0032478 heterotetrameric polyprenyl diphosphate synthase complex;GO:0032476 polyprenyl diphosphate synthase complex",
        "go_biological_process": "GO:0006744 ubiquinone biosynthetic process;GO:0008299 isoprenoid biosynthetic process;GO:1901663 quinone biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q5T2R2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5VZP5-1",
        "uniprot_id": "STYL2_HUMAN",
        "mass": 130176.0,
        "length": 1158,
        "protein_name": "Serine/threonine/tyrosine-interacting-like protein 2",
        "gene_name": "STYXL2",
        "organism": "Human",
        "refseq_name": "serine/threonine/tyrosine-interacting-like protein 2",
        "refseq_ac": "NP_001073895",
        "gene_names_uniprotkb": "STYXL2; DUSP27",
        "gene_names_refseq": "DUSP27; STYXL2",
        "protein_names_uniprotkb": "Serine/threonine/tyrosine-interacting-like protein 2; Inactive dual specificity phosphatase 27",
        "protein_names_refseq": "dual specificity phosphatase 27 (putative); dual specificity phosphatase 27, atypical; inactive dual specificity phosphatase 27; serine/threonine/tyrosine-interacting-like protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:92235)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "20520587;25880248;27862975;30429286;31844290;32157095;32357974;32938616;35051231;35580925;36010968",
        "class_list": "",
        "function": "May be required for myofiber maturation., [UniProtKB, UniProtKB]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AUM4;Q9C074",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0033549 MAP kinase phosphatase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0030017 sarcomere",
        "go_biological_process": "GO:0043409 negative regulation of MAPK cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q5VZP5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6PGQ1-1",
        "uniprot_id": "DRIC1_HUMAN",
        "mass": 25064.0,
        "length": 229,
        "protein_name": "Aspartate-rich protein 1",
        "gene_name": "DRICH1",
        "organism": "Human",
        "refseq_name": "aspartate-rich protein 1",
        "refseq_ac": "NP_057533",
        "gene_names_uniprotkb": "DRICH1; C22orf43",
        "gene_names_refseq": "C22orf43; DRICH1; KB-208E9.1",
        "protein_names_uniprotkb": "Aspartate-rich protein 1",
        "protein_names_refseq": "aspartate-rich protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51233)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "20237496;29242379;29485866;34087483",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ICJ8;Q6P4I3;Q9NU31",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q6PGQ1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZS02-1",
        "uniprot_id": "DMP46_HUMAN",
        "mass": 23740.0,
        "length": 220,
        "protein_name": "Putative GED domain-containing protein DNM1P46",
        "gene_name": "DNM1P46",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DNM1P46; C15orf51",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative GED domain-containing protein DNM1P46; DNM1 pseudogene 46",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "38253038",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3ZCN3",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q6ZS02-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z7J5-1",
        "uniprot_id": "DPPA2_HUMAN",
        "mass": 33784.0,
        "length": 298,
        "protein_name": "Developmental pluripotency-associated protein 2",
        "gene_name": "DPPA2",
        "organism": "Human",
        "refseq_name": "developmental pluripotency-associated protein 2",
        "refseq_ac": "NP_620170",
        "gene_names_uniprotkb": "DPPA2; PESCRG1",
        "gene_names_refseq": "CT100; DPPA2; ECAT15-2; PESCRG1",
        "protein_names_uniprotkb": "Developmental pluripotency-associated protein 2; Pluripotent embryonic stem cell-related gene 1 protein",
        "protein_names_refseq": "cancer/testis antigen 100; developmental pluripotency-associated protein 2; embryonic stem cell (ESC) associated transcript 15-2; pluripotent embryonic stem cell-related gene 1 protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:151871);  (R-HSA-9819196)",
        "pathway_count": 2,
        "publication_count": 22,
        "publication_id_list": "15583978;18467432;18519755;19705800;22209328;23934149;24278031;26360614;26951377;27062923;28459456;28459457;29093164;31630170;33316032;33862460;34267371;34721660;35051231;35402882;35580925;36074823",
        "class_list": "",
        "function": "Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes., [UniProtKB]; Differential expression of the embryo/cancer gene ECSA(DPPA2) in human preimplantation development., [RefSeq, PubMed]; Dppa2/4 as a trigger of signaling pathways to promote zygote genome activation by binding to CG-rich region., [RefSeq, PubMed]; ECSA/DPPA2 is a promising target for antigen-specific immunotherapy in non-small cell lung cancers, [RefSeq, PubMed]; In normal tissues, PLAC1 expression was restricted to the placenta while DPPA2 expression was restricted to the placenta and testis. Publication Status: Online-Only, [RefSeq, PubMed]; SPOP suppresses testicular germ cell tumors progression through ubiquitination and degradation of DPPA2., [RefSeq, PubMed]; Transcription Factor CTCFL Promotes Cell Proliferation, Migration, and Invasion in Gastric Cancer via Activating DPPA2. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8WVF0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0048731 system development;GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q7Z7J5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86SJ6-1",
        "uniprot_id": "DSG4_HUMAN",
        "mass": 113824.0,
        "length": 1040,
        "protein_name": "Desmoglein-4",
        "gene_name": "DSG4",
        "organism": "Human",
        "refseq_name": "desmoglein-4 isoform 1 precursor",
        "refseq_ac": "NP_001127925",
        "gene_names_uniprotkb": "DSG4; CDHF13",
        "gene_names_refseq": "CDGF13; CDHF13; DSG4; HYPT6; LAH",
        "protein_names_uniprotkb": "Desmoglein-4; Cadherin family member 13",
        "protein_names_refseq": "cadherin family member 13; desmoglein-4 isoform 1 precursor",
        "tax_id": 9606,
        "disease": "hypotrichosis 6 (Disease Ontology:DOID:0110703); hypotrichosis (Disease Ontology:DOID:4535); alopecia (Disease Ontology:DOID:987)",
        "pathway": " (hsa:147409);  (R-HSA-6805567);  (R-HSA-6809371)",
        "pathway_count": 3,
        "publication_count": 70,
        "publication_id_list": "10066784;10196183;10231017;10411887;10588656;10771479;11350120;11380615;11590230;12648213;12705872;12902340;15033990;15191570;15337775;15373777;15545999;15797384;15803139;16061697;16297213;16382671;16543896;16639001;1691188;1694855;1714783;17515931;17521629;17562024;17596512;17924679;18843291;19190773;19194479;20068231;20179351;20657595;20667819;20940292;21439340;21495994;21654840;21997417;23481192;23629652;2414304;24220297;24715725;25208914;25892735;25926655;26173648;26390218;29796690;31217245;31844290;32387766;32938616;33158670;33995349;35051231;35146972;35494241;7543090;8824274;8999895;9395522;9468612;9565599",
        "class_list": "",
        "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity). Plays a role in moderating lymphocyte migration to inflamed skin and maintaining homeostasis of the epidermal inflammatory response (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Autosomal recessive monilethrix: Novel variants of the DSG4 gene in three Chinese families., [RefSeq, PubMed]; Case Report: autosomal recessive keratosis pilaris atrophicans caused by mutation in DSG4., [RefSeq, PubMed]; DSG4 is pathogenic in pemphigus and staphylococcal scalded skin syndrome., [RefSeq, PubMed]; Desmoglein-4 Deficiency Exacerbates Psoriasiform Dermatitis in Rats While Psoriasis Patients Displayed a Decreased Gene Expression of DSG4. Publication Status: Online-Only, [RefSeq, PubMed]; The essential role of desmoglein 4 in skin was established by identifying mutations in families with inherited hypotrichosis, as well as in the lanceolate hair mouse. We also show that DSG4 is an autoantigen in pemphigus vulgaris., [RefSeq, PubMed]; The human desmoglein 4 gene (DSG4) demonstrates that it is composed of 16 exons spanning approximately 37 kb of 18q12 and is situated between DSG1 and DSG3., [RefSeq, PubMed]; This gene encodes a member of the desmoglein subgroup of desmosomal cadherins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a transmembrane component of desmosomes and may play a role in cell-cell adhesion in epithelial cells. Mutations in the gene are associated with localized autosomal recessive hypotrichosis and monilethrix, characterized by impaired hair growth. [provided by RefSeq, May 2016]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 41,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RUI1;Q6Y9L9;Q8IXV4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0001533 cornified envelope;GO:0030057 desmosome",
        "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules",
        "synthesized_glycan_count": 0,
        "hit_score": 7.1,
        "record_id": "Q86SJ6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IXB1-1",
        "uniprot_id": "DJC10_HUMAN",
        "mass": 91080.0,
        "length": 793,
        "protein_name": "Endoplasmic reticulum disulfide reductase DNAJC10",
        "gene_name": "DNAJC10",
        "organism": "Human",
        "refseq_name": "endoplasmic reticulum disulfide reductase DNAJC10 isoform 2",
        "refseq_ac": "NP_001258510",
        "gene_names_uniprotkb": "DNAJC10; ERDJ5; PRO1012",
        "gene_names_refseq": "DNAJC10; ERdj5; JPDI; MTHr; PDIA19",
        "protein_names_uniprotkb": "Endoplasmic reticulum disulfide reductase DNAJC10; 1.8.4.2; DnaJ homolog subfamily C member 10; ER-resident protein ERdj5; Endoplasmic reticulum DNA J domain-containing protein 5; MTHr; Macrothioredoxin",
        "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 10; ER-resident protein ERdj5; J-domain-containing protein disulfide isomerase-like protein; dnaJ homolog subfamily C member 10; endoplasmic reticulum DNA J domain-containing protein 5; endoplasmic reticulum disulfide reductase DNAJC10 isoform 2; endoplasmic reticulum disulfide reductase DNAJC10; macrothioredoxin; protein disulfide isomerase family A, member 19",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54431);  (R-HSA-9918432)",
        "pathway_count": 2,
        "publication_count": 98,
        "publication_id_list": "10228156;11237011;12411443;12446677;12975309;14587667;16303743;18400946;19122239;23481700;23769672;24714562;24715725;25576301;26154972;26208004;26375851;26992070;27383988;27862975;28218747;28228285;28228593;28510447;28649982;28832583;28834231;28855257;28904123;29242379;29437277;29493099;29557506;29632046;29786170;30315122;30410026;30429286;30484775;30524438;30573663;30779550;30833945;31154438;31217245;31222486;31530632;31844290;31848261;31937595;32157095;32161166;32196553;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33043033;33123756;33141586;33298915;33392160;33592498;33633747;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34357683;34405274;34509645;34561969;34725712;34932366;34988580;35051231;35215835;35251023;35561310;35580925;36010968;36215666;36241641;36284347;37496439;37739037;37938771;38665916;38793607;39031896;40914422",
        "class_list": "",
        "function": "AAV-mediated ERdj5 overexpression protects against P23H rhodopsin toxicity., [RefSeq, PubMed]; DNAJC10 correlates with tumor immune characteristics and predicts the prognosis of glioma patients., [RefSeq, PubMed]; DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response. Publication Status: Online-Only, [RefSeq, PubMed]; ERdj4 and ERdj5 promote turnover of misfolded SP-C and this activity is dependent on their ability to stimulate BiP ATPase activity., [RefSeq, PubMed]; ERdj5 is a ubiquitous protein localized in the ER and is particularly abundant in secretory cells. Its transcription is induced during ER stress, suggesting potential roles for ERdj5 in protein folding and translocation across the ER membrane., [RefSeq, PubMed]; Endoplasmic reticulum disulfide reductase that collaborates directly with the chaperone BIP/HSPA5 (GRP78) to maintain protein quality control by facilitating either the correct folding or the targeted degradation of misfolded proteins. Essential for efficient maturation of newly synthesized polypeptides in the endoplasmic reticulum, binds to substrate proteins and specifically catalyzes the reduction and removal of improper (non-native) disulfide bonds during the folding process. In endoplasmic reticulum-associated degradation (ERAD), DNAJC10 reduces incorrect disulfide bonds specifically in misfolded glycoproteins that have been recognized by EDEM1, a key component of the ERAD pathway, thereby enabling their retrotranslocation and degradation. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; JPDI may have roles in folding of some proteins in the ER, chaperoning by BiP and formation of proper disulfide bonds, [RefSeq, PubMed]; MCM8 promotes lung cancer progression through upregulating DNAJC10., [RefSeq, PubMed]; Mechanistic characterization of disulfide bond reduction of an ERAD substrate mediated by cooperation between ERdj5 and BiP., [RefSeq, PubMed]; The organization of the functional motifs of hMTHr suggests that the protein might be a member of a molecular chaperone family., [RefSeq, PubMed]; This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q17RJ6;Q3B7W8;Q4ZG06;Q53QT7;Q6UWZ6;Q86T61;Q8NC82;Q8TD87;Q96K38;Q96K44;Q96K54;Q9NSY6",
        "ec_number_list": "1.8.4.2;3.6.4.10",
        "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity;GO:0019153 protein-disulfide reductase (glutathione) activity;GO:0051087 protein-folding chaperone binding;GO:0051117 ATPase binding;GO:0001671 ATPase activator activity",
        "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0016020 membrane",
        "go_biological_process": "GO:0036498 IRE1-mediated unfolded protein response;GO:0036503 ERAD pathway;GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0034976 response to endoplasmic reticulum stress;GO:0034975 protein folding in endoplasmic reticulum",
        "synthesized_glycan_count": 0,
        "hit_score": 10.1,
        "record_id": "Q8IXB1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IXT2-1",
        "uniprot_id": "DMRTD_HUMAN",
        "mass": 39124.0,
        "length": 367,
        "protein_name": "Doublesex- and mab-3-related transcription factor C2",
        "gene_name": "DMRTC2",
        "organism": "Human",
        "refseq_name": "doublesex- and mab-3-related transcription factor C2",
        "refseq_ac": "NP_001035373",
        "gene_names_uniprotkb": "DMRTC2",
        "gene_names_refseq": "DMRT7; DMRTC2",
        "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor C2",
        "protein_names_refseq": "doublesex- and mab-3-related transcription factor C2",
        "tax_id": 9606,
        "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)",
        "pathway": " (hsa:63946)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "11237011;11863363;32488085",
        "class_list": "",
        "function": "May be involved in sexual development., [UniProtKB, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N6Q2;Q96M39;Q96SD4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0043565 sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0001741 XY body",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0007548 sex differentiation;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q8IXT2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IY82-1",
        "uniprot_id": "DRC7_HUMAN",
        "mass": 103497.0,
        "length": 874,
        "protein_name": "Dynein regulatory complex subunit 7",
        "gene_name": "DRC7",
        "organism": "Human",
        "refseq_name": "dynein regulatory complex subunit 7 isoform a",
        "refseq_ac": "NP_001276091",
        "gene_names_uniprotkb": "DRC7; C16orf50; CCDC135",
        "gene_names_refseq": "C16orf50; CCDC135; CFAP50; DRC7; FAP50",
        "protein_names_uniprotkb": "Dynein regulatory complex subunit 7; Coiled-coil domain-containing protein 135; Coiled-coil domain-containing protein lobo homolog",
        "protein_names_refseq": "coiled-coil domain containing 135; coiled-coil domain-containing protein 135; coiled-coil domain-containing protein lobo homolog; dynein regulatory complex subunit 7 isoform a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84229)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11230166;11237011;26992070;27920218;28832583;29393594;29557506;31844290;32357974;32387766;32502341;33968037;34509645;35051231;35494241;36010968;37217939;39894887",
        "class_list": "",
        "function": "Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Involved in the regulation of flagellar motility (By similarity). Essential for male fertility, sperm head morphogenesis and sperm flagellum formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K943;Q8NAA0;Q9H080",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0031514 motile cilium;GO:0005930 axoneme;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0003341 cilium movement;GO:0007288 sperm axoneme assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q8IY82-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N608-1",
        "uniprot_id": "DPP10_HUMAN",
        "mass": 90888.0,
        "length": 796,
        "protein_name": "Inactive dipeptidyl peptidase 10",
        "gene_name": "DPP10",
        "organism": "Human",
        "refseq_name": "inactive dipeptidyl peptidase 10 isoform c",
        "refseq_ac": "NP_001171505",
        "gene_names_uniprotkb": "DPP10; DPRP3; KIAA1492",
        "gene_names_refseq": "DPL2; DPP10; DPPY; DPRP-3; DPRP3",
        "protein_names_uniprotkb": "Inactive dipeptidyl peptidase 10; DPL2; DPP X; DPRP-3; Dipeptidyl peptidase IV-related protein 3; Dipeptidyl peptidase X; Dipeptidyl peptidase-like protein 2",
        "protein_names_refseq": "DPP X; dipeptidyl peptidase IV-related protein 3; dipeptidyl peptidase X; dipeptidyl peptidase-like protein 2; dipeptidyl-peptidase 10 (inactive); dipeptidyl-peptidase 10 (non-functional); inactive dipeptidyl peptidase 10 isoform c; inactive dipeptidyl peptidase 10",
        "tax_id": 9606,
        "disease": "asthma (Disease Ontology:DOID:2841)",
        "pathway": " (hsa:57628)",
        "pathway_count": 1,
        "publication_count": 22,
        "publication_id_list": "11237011;12662155;12675227;14566338;15454437;15671030;16899223;17081983;18669648;19237393;22387313;29361513;29557506;29671580;30199657;30638748;31844290;32387766;34019948;34431147;35051231;37242299",
        "class_list": "glycogene",
        "function": "Cloning, characterization and mapping to chromosome 2, [RefSeq, PubMed]; Contribution of dipeptidyl peptidase 10 to airway dysfunction in patients with NSAID-exacerbated respiratory disease., [RefSeq, PubMed]; Increased ventricular DPP10 expression in heart failure might promote arrhythmias by decreasing peak Na(+) current, while increasing window Na(+) current and channel re-openings due to accelerated recovery from inactivation, [RefSeq, PubMed]; Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy. Publication Status: Online-Only, [RefSeq, PubMed]; Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155)., [UniProtKB, PubMed, PubMed, PubMed]; SNP rs11693320 associated with pulmonary function when incorporating an interaction with docosahexaenoic acid, [RefSeq, PubMed]; These results show that a Dpp10 point mutation leads to increased airway responsiveness following allergen challenge. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 7,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 7,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 6,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 1057,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 1,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K1Q2;J3KPP2;J3KQ46;Q0GLB8;Q53QT3;Q53S86;Q53SL8;Q53SS4;Q6TTV4;Q86YR9;Q9P236",
        "ec_number_list": "",
        "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0008236 serine-type peptidase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex",
        "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0006508 proteolysis;GO:0072659 protein localization to plasma membrane;GO:1903078 positive regulation of protein localization to plasma membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q8N608-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TE96-1",
        "uniprot_id": "DQX1_HUMAN",
        "mass": 79476.0,
        "length": 717,
        "protein_name": "ATP-dependent RNA helicase homolog DQX1",
        "gene_name": "DQX1",
        "organism": "Human",
        "refseq_name": "ATP-dependent RNA helicase homolog DQX1",
        "refseq_ac": "NP_598376",
        "gene_names_uniprotkb": "DQX1",
        "gene_names_refseq": "DQX1",
        "protein_names_uniprotkb": "ATP-dependent RNA helicase homolog DQX1; DEAQ box polypeptide 1",
        "protein_names_refseq": "ATP-dependent RNA helicase DQX1; ATP-dependent RNA helicase homolog DQX1; DEAQ RNA-dependent ATPase DQX1; DEAQ box polypeptide 1 (RNA-dependent ATPase)",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:165545)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "11237011;11353393;23481700;25576301;29557506;32218699;33141586;33392160;34171305;34185709;35051231;37217939",
        "class_list": "",
        "function": "Integrative analysis of DNA methylation-driven genes for the prognosis of lung squamous cell carcinoma using MethylMix. Publication Status: Online-Only, [RefSeq, PubMed]; Might be involved in RNA metabolism; it is missing helicase motif III and may not have helicase activity (PubMed:11353393)., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6B017;Q8NAM8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0004386 helicase activity",
        "go_cellular_component": "GO:0005681 spliceosomal complex",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q8TE96-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TEA8-1",
        "uniprot_id": "DTD1_HUMAN",
        "mass": 23424.0,
        "length": 209,
        "protein_name": "D-aminoacyl-tRNA deacylase 1",
        "gene_name": "DTD1",
        "organism": "Human",
        "refseq_name": "D-aminoacyl-tRNA deacylase 1 isoform 1",
        "refseq_ac": "NP_001304972",
        "gene_names_uniprotkb": "DTD1; C20orf88; DUEB; HARS2",
        "gene_names_refseq": "C20orf88; DTD1; DTD; DUE-B; DUEB; HARS2; pqn-68",
        "protein_names_uniprotkb": "D-aminoacyl-tRNA deacylase 1; 3.1.1.96; DNA-unwinding element-binding protein B; DTD; DUE-B; Gly-tRNA(Ala) deacylase; Histidyl-tRNA synthase-related",
        "protein_names_refseq": "D-aminoacyl-tRNA deacylase 1 isoform 1; D-tyrosyl-tRNA deacylase 1 homolog; D-tyrosyl-tRNA(Tyr) deacylase 1; DNA-unwinding element-binding protein B; gly-tRNA(Ala) deacylase; histidyl-tRNA synthase-related; histidyl-tRNA synthetase 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:92675)",
        "pathway_count": 1,
        "publication_count": 47,
        "publication_id_list": "11237011;12392168;15653697;17264083;17287340;18088087;18491316;18669648;19413330;19415658;19651622;19664994;19690332;20065034;20068231;20166139;21406692;21479357;22645359;23186163;24772479;25258324;26024233;26154972;28904123;29437277;29493099;29557506;30037903;30410026;30429286;31844290;32157095;32350084;32387766;32938616;32983136;33592498;33633747;33968037;34357683;34433824;34509645;35051231;35318648;35580925;37938771",
        "class_list": "",
        "function": "An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Cloning and identification of novel cDNA which may be associated with FKBP25, [RefSeq, PubMed]; DTD1 variants do not affect the abnormalities of the upper airways in aspirin-intolerant asthma patients, [RefSeq, PubMed]; DUE-B, a c-myc DNA-unwinding element-binding protein, plays an important role in replication in vivo., [RefSeq, PubMed]; LDI-PCR revealed a fusion between DTD1 exon 4 and PDGFRB exon 12 in the cases with t(5;14)(q33;q32) and t(5;20)(q33;p11)., [RefSeq, PubMed]; Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034)., [UniProtKB, PubMed, PubMed]; Results suggest that DUE-B acts to identify origins by MCM binding and serves as a node for replication protein recruitment and Cdc45 transfer to the prereplication complex, [RefSeq, PubMed]; The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]., [RefSeq]; The state of DUE-B phosphorylation is maintained by the equilibrium between Cdc7-dependent phosphorylation and PP2A-dependent dephosphorylation., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5X5;D3DW37;Q496D1;Q5W184;Q8WXU8;Q9BW67;Q9H464;Q9H474",
        "ec_number_list": "3.1.1.96",
        "go_molecular_function": "GO:0051500 D-tyrosyl-tRNA(Tyr) deacylase activity;GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0000049 tRNA binding;GO:0106026 Gly-tRNA(Ala) deacylase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion",
        "go_biological_process": "GO:0006399 tRNA metabolic process;GO:0006260 DNA replication",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q8TEA8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WTR2-1",
        "uniprot_id": "DUS19_HUMAN",
        "mass": 24194.0,
        "length": 217,
        "protein_name": "Dual specificity protein phosphatase 19",
        "gene_name": "DUSP19",
        "organism": "Human",
        "refseq_name": "dual specificity protein phosphatase 19 isoform 2",
        "refseq_ac": "NP_001135786",
        "gene_names_uniprotkb": "DUSP19; DUSP17; LMWDSP3; SKRP1",
        "gene_names_refseq": "DUSP17; DUSP19; LMWDSP3; SKRP1; TS-DSP1",
        "protein_names_uniprotkb": "Dual specificity protein phosphatase 19; 3.1.3.16; 3.1.3.48; Dual specificity phosphatase TS-DSP1; LMW-DSP3; Low molecular weight dual specificity phosphatase 3; Protein phosphatase SKRP1; SAPK pathway-regulating phosphatase 1; Stress-activated protein kinase pathway-regulating phosphatase 1",
        "protein_names_refseq": "SAPK pathway-regulating phosphatase 1; dual specificity phosphatase TS-DSP1; dual specificity protein phosphatase 19 isoform 2; dual specificity protein phosphatase 19; low molecular weight dual specificity phosphatase 3; protein phosphatase SKRP1; stress-activated protein kinase pathway-regulating phosphatase 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:142679)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11959862;12479873;21989941;27600516;30379171;31154438;31813339;32488085;33770577;36336681",
        "class_list": "",
        "function": "Circ_HIPK3 alleviates CoCl2-induced apoptotic injury in neuronal cells by depending on the regulation of the miR-222-3p/DUSP19 axis., [RefSeq, PubMed]; DUSP19 mediates spinal cord injury-induced apoptosis and inflammation in mouse primary microglia cells via the NF-kB signaling pathway., [RefSeq, PubMed]; Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]., [RefSeq]; Has a dual specificity toward Ser/Thr and Tyr-containing proteins., [UniProtKB, PubMed]; LMW-DSP3 was expressed in the heart, lung, liver, and pancreas, and the expression level in the pancreas was highest. The LMW-DSP3 gene was located in human chromosome 2q32, and consisted of five exons spanning 21kb of human genomic DNA[LMW-DSP3], [RefSeq, PubMed]; PTEN regulates invasiveness in pancreatic neuroendocrine tumors through DUSP19-mediated VEGFR3 dephosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RA79;Q547H4;Q8WYN4",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.21;3.1.3.18;3.1.3.-;3.1.3.5;3.1.3.2;2.7.10.1;3.1.3.67;3.1.3.53;3.1.3.52;3.1.3.27;3.1.3.86;3.1.3.36;3.1.3.74",
        "go_molecular_function": "GO:0008579 JUN kinase phosphatase activity;GO:0030295 protein kinase activator activity;GO:0004722 protein serine/threonine phosphatase activity;GO:0004860 protein kinase inhibitor activity;GO:0005078 MAP-kinase scaffold activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0046330 positive regulation of JNK cascade;GO:0046329 negative regulation of JNK cascade;GO:0046328 regulation of JNK cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q8WTR2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96MA1-1",
        "uniprot_id": "DMRTB_HUMAN",
        "mass": 36205.0,
        "length": 342,
        "protein_name": "Doublesex- and mab-3-related transcription factor B1",
        "gene_name": "DMRTB1",
        "organism": "Human",
        "refseq_name": "doublesex- and mab-3-related transcription factor B1",
        "refseq_ac": "NP_149056",
        "gene_names_uniprotkb": "DMRTB1",
        "gene_names_refseq": "DMRT6; DMRTB1",
        "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor B1",
        "protein_names_refseq": "doublesex- and mab-3-related transcription factor B1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:63948)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11863363;30192525;30920770;31844290;33912179;35051231",
        "class_list": "",
        "function": "Role in the entry of spermatogonia into meiosis, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96SD2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007548 sex differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q96MA1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96PT3-1",
        "uniprot_id": "DUX5_HUMAN",
        "mass": 22164.0,
        "length": 197,
        "protein_name": "Double homeobox protein 5",
        "gene_name": "DUX5",
        "organism": "Human",
        "refseq_name": "double homeobox protein 5",
        "refseq_ac": "NP_036281",
        "gene_names_uniprotkb": "DUX5",
        "gene_names_refseq": "DUX1; DUX5",
        "protein_names_uniprotkb": "Double homeobox protein 5",
        "protein_names_refseq": "double homeobox protein 1; double homeobox protein 5; epididymis secretory sperm binding protein",
        "tax_id": 9606,
        "disease": "temporal arteritis (Disease Ontology:DOID:13375)",
        "pathway": " (hsa:26581);  (hsa:26584)",
        "pathway_count": 2,
        "publication_count": 1,
        "publication_id_list": "11245978",
        "class_list": "",
        "function": "The human genome contains hundreds of repeats of the 3.3-kb family in regions associated with heterochromatin. The DUX gene family, including DUX5, resides within these 3.3-kb repeated elements (Beckers et al., 2001 [PubMed 11245978]). See DUX4 (MIM 606009).[supplied by OMIM, Mar 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "Q96PT3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96SC8-1",
        "uniprot_id": "DMTA2_HUMAN",
        "mass": 53356.0,
        "length": 542,
        "protein_name": "Doublesex- and mab-3-related transcription factor A2",
        "gene_name": "DMRTA2",
        "organism": "Human",
        "refseq_name": "doublesex- and mab-3-related transcription factor A2",
        "refseq_ac": "NP_115486",
        "gene_names_uniprotkb": "DMRTA2; DMRT5",
        "gene_names_refseq": "DMRT5; DMRTA2",
        "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor A2; Doublesex- and mab-3-related transcription factor 5",
        "protein_names_refseq": "doublesex- and mab-3-related transcription factor 5; doublesex- and mab-3-related transcription factor A2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:63950)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11863363;25082981;26757254;32350084;32387766;32938616;35051231;35251023;38509074",
        "class_list": "",
        "function": "DMRTA2 supports glioma stem-cell mediated neovascularization in glioblastoma. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that loss of function of doublesex and mab-3-related transcription factor a2 (DMRTA2) leads to disorder of cortical development., [RefSeq, PubMed]; May be involved in sexual development., [UniProtKB]; This study reveals, for the first time, the requirement of DMRTA2 for normal human female embryonic germ cell development. Erratum:[Mol Hum Reprod. 2015 Jul;21(7):615. doi: 10.1093/molehr/gav029. Mucsynski, Vincent [Corrected to Muczynski, Vincent]. PMID: 26134375], [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5TFQ3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007548 sex differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q96SC8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BTV6-1",
        "uniprot_id": "DPH7_HUMAN",
        "mass": 50575.0,
        "length": 452,
        "protein_name": "Diphthine methyltransferase",
        "gene_name": "DPH7",
        "organism": "Human",
        "refseq_name": "diphthine methyltransferase isoform a",
        "refseq_ac": "NP_620133",
        "gene_names_uniprotkb": "DPH7; C9orf112; WDR85",
        "gene_names_refseq": "C9orf112; DPH7; RRT2; WDR85",
        "protein_names_uniprotkb": "Diphthine methyltransferase; 3.1.1.97; Diphthamide biosynthesis protein 7; WD repeat-containing protein 85",
        "protein_names_refseq": "WD repeat-containing protein 85; diphthine methyltransferase isoform a; diphthine methyltransferase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:92715);  (R-HSA-5358493)",
        "pathway_count": 2,
        "publication_count": 26,
        "publication_id_list": "1508200;15485916;18627462;19965467;20559380;21750715;23169644;23186163;23468660;23486472;23645155;23971743;24422557;24739148;25352115;26992070;28904123;29437277;30410026;30444036;31844290;32387766;32938616;3346227;33968037;35051231",
        "class_list": "",
        "function": "Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta)., [UniProtKB, PubMed, UniProtKB, PubMed]; Diphthamide is a post-translationally modified histidine residue present in elongation factor 2, and is the target of diphtheria toxin. This gene encodes a protein that contains a WD-40 domain, and is thought to be involved in diphthamide biosynthesis. A similar protein in yeast functions as a methylesterase, converting methylated diphthine to diphthine, which can then undergo amidation to produce diphthamide. [provided by RefSeq, Oct 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96AB7",
        "ec_number_list": "3.6.5.-;3.1.1.97",
        "go_molecular_function": "GO:0061685 diphthine methylesterase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0017183 protein histidyl modification to diphthamide",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q9BTV6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BTZ2-1",
        "uniprot_id": "DHRS4_HUMAN",
        "mass": 29537.0,
        "length": 278,
        "protein_name": "Dehydrogenase/reductase SDR family member 4",
        "gene_name": "DHRS4",
        "organism": "Human",
        "refseq_name": "dehydrogenase/reductase SDR family member 4 isoform 2",
        "refseq_ac": "NP_001269916",
        "gene_names_uniprotkb": "DHRS4; PRO1800; SDR25C2",
        "gene_names_refseq": "CR; DHRS4; NRDR; PHCR; PSCD; SCAD-SRL; SDR-SRL; SDR25C1; SDR25C2",
        "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 4; 1.1.1.184; CR; NADPH-dependent carbonyl reductase; NADPH-dependent retinol dehydrogenase/reductase; NRDR; PSCD; Peroxisomal short-chain alcohol dehydrogenase; Protein SDR25C2; SCAD-SRL; Short chain dehydrogenase/reductase family 25C member 2; Short-chain dehydrogenase/reductase family member 4; humNRDR",
        "protein_names_refseq": "NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; NADPH-dependent carbonyl reductase; NADPH-dependent retinol dehydrogenase/reductase; dehydrogenase/reductase (SDR family) member 4 like 2A; dehydrogenase/reductase SDR family member 4 isoform 2; peroxisomal short-chain alcohol dehydrogenase; short chain dehydrogenase/reductase family 25C member 2; short chain dehydrogenase/reductase family 25C, member 1; short-chain dehydrogenase/reductase family member 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10901);  (R-HSA-5365859);  (R-HSA-9033241)",
        "pathway_count": 3,
        "publication_count": 119,
        "publication_id_list": "10022913;10329026;10333503;10369264;10562279;10673331;10839978;11007799;11101887;11237011;11245473;11546814;11781871;11931631;12036956;12226107;12456682;12559034;12578380;12680773;12717447;12885776;12975309;14532297;14596915;15473316;15545321;15858711;16854980;17007944;17230527;17726030;18039331;18359941;18571493;18712838;18805086;1889753;19027726;19056333;19197237;19208625;19413330;19584060;19632994;20178365;20801113;21529158;21554508;21621639;21851338;21976670;21980954;22002062;22019272;22057399;22227495;22371489;22747494;23128527;23220587;23963456;24235149;24865970;25016021;25538232;25854684;26086376;26138649;26220973;26344566;26864944;27323117;27597759;27846572;27920218;28521612;28611990;28765278;28787099;28834231;28904123;2935875;29557506;29786170;29789417;3013304;31154438;31217245;31530632;31844290;31848261;31937595;32157095;32350084;32938616;33298915;33592498;33968037;34087483;34171305;34666613;35051231;7719337;7790377;8493914;8824437;8858165;8991089;9090381;9090382;9090383;9228021;9539740;9653144;9668159;9677409;9705317;9837948",
        "class_list": "",
        "function": "AS1eRNA-driven DNA looping and activating histone modifications promote the expression of DHRS4-AS1 to economically control the DHRS4 gene cluster. Publication Status: Online-Only, [RefSeq, PubMed]; Alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 is associated with cervical squamous carcinoma, [RefSeq, PubMed]; An analysis of the relationship between the promoter characteristics and RNA expression of the DHRS4 gene cluster indicated that the development of CpG islands, in addition to the promoter sequence, during mammalian evolution could modulate the dose compensatory regulation of the copy number-varied DHRS4 gene cluster Publication Status: Online-Only, [RefSeq, PubMed]; LncRNA DHRS4-AS1 ameliorates hepatocellular carcinoma by suppressing proliferation and promoting apoptosis via miR-522-3p/SOCS5 axis., [RefSeq, PubMed]; NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Involved in the metabolism of 3beta-hydroxysteroids, isatin and xenobiotic carbonyl compounds. Has a higher catalytic activity for xenobiotic alpha-dicarbonyl compounds, sucha as benzil, than isoform 1 and is involved in benzil detoxification., [UniProtKB, PubMed, PubMed, PubMed]; NRDRB1, an alternatively spliced isoform of NRDR in vivo functions better than NRDR as a dicarbonyl reductase for xenobiotics containing reactive carbonyls., [RefSeq, PubMed]; No detected catalytic activity in vitro, possibly due to the lack of catalytic site., [UniProtKB, PubMed]; Results suggest a novel mechanism of cold inactivation and role of the inducible human DHRS4 in 3beta-hydroxysteroid synthesis and xenobiotic carbonyl metabolism, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RB10;B7WNS9;D3YTB8;E2QRL8;O95162;Q20CR0;Q2LC19;Q2LE81;Q58IU4;Q6E0Y1;Q6UWU3;Q71UQ6;Q8TD03;Q9H3N5;Q9NV08",
        "ec_number_list": "3.6.1.-;3.6.1.77;3.1.2.2;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;2.3.1.42;1.3.3.6;2.3.2.27;1.1.1.184;1.6.5.10;1.1.1.42;1.1.1.300;1.11.1.6;3.4.24.56;1.4.3.3;1.1.1.189;1.1.1.197;1.1.1.196;1.1.1.71;2.6.1.51;2.6.1.44;2.3.1.176;2.3.1.16;2.3.1.155;2.3.2.36;1.14.13.39;4.1.3.4;2.3.1.137;2.3.1.7;1.1.1.270;1.1.1.-;1.1.1.357;1.1.1.62;1.1.1.112;1.1.1.149;1.3.1.20;1.1.1.209;1.1.1.51;1.1.1.210;1.1.1.53;5.3.3.21;2.3.1.65;3.4.21.-;1.5.3.13;3.4.21.53;1.4.3.1;1.3.1.38;1.3.1.124;1.1.3.15;1.5.3.1;1.5.3.7;5.1.99.4;4.1.2.63;1.2.3.5;2.5.1.18",
        "go_molecular_function": "GO:0018455 alcohol dehydrogenase [NAD(P)+] activity;GO:0042802 identical protein binding;GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity;GO:0000253 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005782 peroxisomal matrix",
        "go_biological_process": "GO:0042180 ketone metabolic process;GO:0006066 alcohol metabolic process;GO:0042574 retinal metabolic process;GO:2000379 positive regulation of reactive oxygen species metabolic process;GO:0008202 steroid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 12.0,
        "record_id": "Q9BTZ2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BY84-1",
        "uniprot_id": "DUS16_HUMAN",
        "mass": 73102.0,
        "length": 665,
        "protein_name": "Dual specificity protein phosphatase 16",
        "gene_name": "DUSP16",
        "organism": "Human",
        "refseq_name": "dual specificity protein phosphatase 16",
        "refseq_ac": "NP_085143",
        "gene_names_uniprotkb": "DUSP16; KIAA1700; MKP7",
        "gene_names_refseq": "DUSP16; MKP-7; MKP7",
        "protein_names_uniprotkb": "Dual specificity protein phosphatase 16; 3.1.3.16; 3.1.3.48; MAP kinase phosphatase 7; MKP-7; Mitogen-activated protein kinase phosphatase 7",
        "protein_names_refseq": "MAP kinase phosphatase 7; MAPK phosphatase-7; dual specificity protein phosphatase 16; mitogen-activated protein kinase phosphatase 7",
        "tax_id": 9606,
        "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)",
        "pathway": " (hsa:80824);  (R-HSA-112409);  (R-HSA-5675221);  (R-HSA-9636569);  (R-HSA-9652817)",
        "pathway_count": 5,
        "publication_count": 82,
        "publication_id_list": "10.1101/2023.09.13.557529;10206983;10415025;10490027;10702794;10757792;11237011;11489891;12583813;12794087;14586399;14724641;15664191;15689616;15851477;15888437;16892053;17097642;17208316;17724343;18294816;18332145;18515281;18547165;18669648;19091743;19158341;20122898;20332238;20463170;21779496;22547814;22569528;22730326;23105109;24390348;24714562;24715725;25314968;25576301;25597358;25631445;25880248;25896765;26154972;27760319;28904123;29557506;30315122;30410026;30429286;30484775;30779550;30833945;31154438;31217245;31844290;31848261;31998317;32157095;32357974;32502341;32897882;32938616;32983136;33298915;33592498;33717175;33863904;33912179;33936100;33968037;33981976;34171305;34932366;35051231;35318648;35561310;35580925;36272649;36581221;37217939",
        "class_list": "",
        "function": "A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding., [RefSeq, PubMed]; Activation of the ERK pathway strongly blocks JNK activation through stabilization of MKP-7 mediated by phosphorylation, [RefSeq, PubMed]; Context-dependent role for DUSP16 on cell transformation and apoptosis., [RefSeq, PubMed]; DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death. Publication Status: Online-Only, [RefSeq, PubMed]; Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2., [UniProtKB, PubMed, PubMed]; This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q547C7;Q96QS2;Q9C0G3",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.21;3.1.3.18;3.1.3.-;3.1.3.5;3.1.3.2;2.7.11.24;2.7.10.1;3.1.3.67;3.1.3.53;3.1.3.52;3.1.3.27;3.1.3.86;3.1.3.36;3.1.3.74",
        "go_molecular_function": "GO:0051019 mitogen-activated protein kinase binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0048273 mitogen-activated protein kinase p38 binding;GO:0004721 phosphoprotein phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle",
        "go_biological_process": "GO:0016311 dephosphorylation;GO:0043409 negative regulation of MAPK cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 8.9,
        "record_id": "Q9BY84-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BZ29-1",
        "uniprot_id": "DOCK9_HUMAN",
        "mass": 236446.0,
        "length": 2069,
        "protein_name": "Dedicator of cytokinesis protein 9",
        "gene_name": "DOCK9",
        "organism": "Human",
        "refseq_name": "dedicator of cytokinesis protein 9 isoform b",
        "refseq_ac": "NP_001123520",
        "gene_names_uniprotkb": "DOCK9; KIAA1058; ZIZ1",
        "gene_names_refseq": "DOCK9; ZIZ1; ZIZIMIN1",
        "protein_names_uniprotkb": "Dedicator of cytokinesis protein 9; Cdc42 guanine nucleotide exchange factor zizimin-1; Zizimin-1",
        "protein_names_refseq": "cdc42 guanine nucleotide exchange factor zizimin-1; dedicator of cytokinesis protein 9 isoform b; dedicator of cytokinesis protein 9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23348);  (R-HSA-9013148);  (R-HSA-9013149);  (R-HSA-983231)",
        "pathway_count": 4,
        "publication_count": 345,
        "publication_id_list": "10232922;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10699171;10699464;10724160;10873802;10958683;11007481;11042108;11058585;11062261;11085924;11149925;11237011;11242053;11306516;11373293;11396949;11431473;11432776;11584276;11606631;11672528;11696321;11704860;11707441;11744692;11751636;11756552;11773441;11803464;11804587;11804589;11804590;11884391;11895428;11912491;11948177;11950885;11961559;12032298;12071859;12093360;12096337;12134158;12172552;12195014;12221096;12351724;12427746;12432077;12464619;12531887;12546821;12547822;12650940;12665586;12773384;12857875;12860998;12877655;12907671;12923183;14506234;14512443;14514689;1464587;14675773;14718541;15020713;15023524;15033976;15064355;15107133;15133129;15147912;15157669;15247287;15260990;15302923;15304341;15339924;15342493;15485661;15507211;15579468;15601624;15611138;15710388;15728722;15850391;15858067;15897194;16002401;16054028;16112081;16116428;16184169;16217026;16243036;1630448;16473593;16492808;16507994;16519628;16630611;16636067;16702231;16714282;16762923;16777452;16777849;16862148;16896804;16914516;16964243;16968698;17027967;17064668;17077126;17145773;17196961;17214551;17244649;17583407;17599059;17702745;17728666;17765681;17804252;17932950;17935486;17976533;18006505;18045877;18056264;18218625;18249095;18347018;18363964;18396277;18426980;18491316;18653540;18669648;18691976;18786931;18835169;18838382;18929667;19269969;19293402;19494238;19605563;19664994;19673492;19713215;19745154;19809089;19934221;20068231;20400958;20460433;20530532;20627800;20679435;20810653;21148482;21454492;21542010;21565175;21613211;21685891;21730051;21865595;218813;21989057;22004470;22096251;22298643;22407364;22461490;22475431;22571869;22608513;22734669;22970203;23186163;23200924;23209303;23255595;23271734;23288169;23406282;23434736;23572525;23707487;23718289;23940355;24086303;24259668;24275569;24335996;24352656;24584464;24715725;24859002;24933155;24960694;24996924;25024229;25211221;25428919;25576301;25704760;25721503;25795300;25862245;25963737;26129894;26154972;26299518;26529257;26598554;26641546;26845023;26887924;26992070;27096001;27117132;27145964;27216196;27397612;27481945;27555588;27566826;27600516;27713499;27798618;27806292;28028151;28114311;28196833;28825699;28860633;29089502;29242379;29358323;29382922;29493099;29557506;29786170;30061681;30192525;30315122;30779550;30853411;31154438;31217245;31530632;31844290;31848261;31871319;31998317;32157095;32161166;32203420;32357974;32488085;32502341;32938616;32983136;33298915;33592498;33717175;33912179;33968037;33981976;3409321;34509645;34561969;34741163;35051231;35580925;36241641;36284347;37938771;7479768;7512369;7559638;7673236;7721814;7753201;7835339;8021274;8107774;8537347;8543060;8643598;8645157;8649427;8662638;8662891;8670801;8756646;8769096;8798539;8805223;8810315;8816443;8816476;8939998;8990121;8994827;9013646;9065479;9099726;9113980;9230307;9268338;9305890;9326583;9331217;9405671;9422515;9438849;9490638;9497316;9582072;9659915;9670022;9792683;9822598;9829970;9843499;9846874;9927674;9988689",
        "class_list": "",
        "function": "C.2262A>C substitution in DOCK9 leads to a splicing aberration. However, because the mutation effect was observed in vitro, a definitive relationship between DOCK9 and KTCN phenotype could not be established., [RefSeq, PubMed]; DOCK9 contributes to both risk and increased illness severity in bipolar disorder. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders., [RefSeq, PubMed]; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation., [UniProtKB, PubMed, PubMed]; Novel functions for the N-terminal region of zizimin1., [RefSeq, PubMed]; Sequence comparison combined with mutational analysis identified a new domain, which we named CZH2, that mediates direct interaction with Cdc42, [RefSeq, PubMed]; Studies indicate that that many of the mechanistic principles of the exchange process are conserved in the DOCK9-catalyzed reaction. Publication Status: Online-Only, [RefSeq, PubMed]; Through structural analysis of DOCK9-Cdc42 complexes, we identify a nucleotide sensor within the alpha10 helix of the DHR2 domain that contributes to release of guanine diphosphate (GDP) and then to discharge of the activated GTP-bound Cdc42, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 24,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KX25;E9PFM9;Q5JUD4;Q5JUD6;Q5T2Q1;Q5TAN8;Q9BZ25;Q9BZ26;Q9BZ27;Q9BZ28;Q9UPU4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0045296 cadherin binding;GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0043547 positive regulation of GTPase activity;GO:0007264 small GTPase-mediated signal transduction;GO:0035023 regulation of Rho protein signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 34.8,
        "record_id": "Q9BZ29-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H4G8-1",
        "uniprot_id": "DPH3B_HUMAN",
        "mass": 8721.0,
        "length": 78,
        "protein_name": "Putative DPH3 homolog B",
        "gene_name": "DPH3P1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DPH3P1; C20orf143; DPH3B; ZCSL1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative DPH3 homolog B; CSL-type zinc finger-containing protein 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005506 iron ion binding",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0017183 protein histidyl modification to diphthamide",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "Q9H4G8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NRD8-1",
        "uniprot_id": "DUOX2_HUMAN",
        "mass": 175364.0,
        "length": 1548,
        "protein_name": "Dual oxidase 2",
        "gene_name": "DUOX2",
        "organism": "Human",
        "refseq_name": "dual oxidase 2 isoform 1 precursor",
        "refseq_ac": "NP_054799",
        "gene_names_uniprotkb": "DUOX2; LNOX2; THOX2",
        "gene_names_refseq": "DUOX2; LNOX2; NOXEF2; P138-TOX; TDH6; THOX2",
        "protein_names_uniprotkb": "Dual oxidase 2; 1.-.-.-; 1.11.1.-; 1.6.3.1; Large NOX 2; Long NOX 2; NADH/NADPH thyroid oxidase p138-tox; NADPH oxidase/peroxidase DUOX2; NADPH thyroid oxidase 2; Thyroid oxidase 2; p138 thyroid oxidase",
        "protein_names_refseq": "NADH/NADPH thyroid oxidase p138-tox; NADPH oxidase/peroxidase DUOX2; NADPH thyroid oxidase 2; dual oxidase 2 isoform 1 precursor; dual oxidase-like domains 2; flavoprotein NADPH oxidase; large NOX 2; long NOX 2; nicotinamide adenine dinucleotide phosphate oxidase; p138 thyroid oxidase",
        "tax_id": 9606,
        "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); primary bacterial infectious disease (Disease Ontology:DOID:0050338); thyroid dyshormonogenesis 6 (Disease Ontology:DOID:0112189); hypothyroidism (Disease Ontology:DOID:1459); cholera (Disease Ontology:DOID:1498); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); phenylketonuria (Disease Ontology:DOID:9281)",
        "pathway": " (hsa:50506);  (R-HSA-209968)",
        "pathway_count": 2,
        "publication_count": 41,
        "publication_id_list": "10601291;10806195;11237011;11514595;11822874;12110737;12824283;15210697;15561711;15591162;15972824;16134168;16322276;16651268;16910871;1722671;19144650;20187165;24715725;25761904;25892735;26301257;29557506;29769354;29786170;29789417;30620550;31154438;31217245;32502341;34185709;34784249;35051231;36284347;36607642;37517801;38757580;39126042;39126279;67547;8806637",
        "class_list": "",
        "function": "Another Breach in the Wall: Impaired Epithelial DUOX2 Activity Fuels Metabolic Syndrome., [RefSeq, PubMed]; DUOX2 regulates secreted factors in virus-infected respiratory epithelial cells that contribute to neutrophil attraction and activation., [RefSeq, PubMed]; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO (PubMed:15972824). Plays a role in thyroid hormone synthesis. Also required for lactoperoxidase-mediated antimicrobial defense at the surface of mucosa (PubMed:12824283). Synthesizes NAADP from its reduced NAADPH form which promotes Ca(2+) signaling during T cell activation (PubMed:34784249). May have its own peroxidase activity through its N-terminal peroxidase-like domain., [UniProtKB, PubMed, PubMed, PubMed]; Molecular and Clinical Features of Congenital Hypothyroidism Due to Multiple DUOX2 Variants., [RefSeq, PubMed]; Patients with Thyroid Dyshormonogenesis and DUOX2 Variants: Molecular and Clinical Description and Genotype-Phenotype Correlation. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 45,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MQ13;D2XI64;Q9NR02;Q9UHF9",
        "ec_number_list": "1.11.1.8;1.14.13.-;1.6.3.1;1.14.13.8;1.-.-.-;1.14.13.225;1.6.99.1;1.11.1.-",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0020037 heme binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0004601 peroxidase activity;GO:0016175 superoxide-generating NAD(P)H oxidase activity",
        "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface",
        "go_biological_process": "GO:0042335 cuticle development;GO:0006952 defense response;GO:0006979 response to oxidative stress;GO:0009615 response to virus;GO:0090303 positive regulation of wound healing",
        "synthesized_glycan_count": 0,
        "hit_score": 4.4,
        "record_id": "Q9NRD8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NX36-1",
        "uniprot_id": "DJC28_HUMAN",
        "mass": 45806.0,
        "length": 388,
        "protein_name": "DnaJ homolog subfamily C member 28",
        "gene_name": "DNAJC28",
        "organism": "Human",
        "refseq_name": "dnaJ homolog subfamily C member 28",
        "refseq_ac": "NP_001035282",
        "gene_names_uniprotkb": "DNAJC28; C21orf55; C21orf78",
        "gene_names_refseq": "C21orf55; C21orf78; DNAJC28",
        "protein_names_uniprotkb": "DnaJ homolog subfamily C member 28",
        "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 28; dnaJ homolog subfamily C member 28",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54943)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "12036298;17693683;28649982;30779550;32350084;32387766;32938616;33968037;34509645;35251023",
        "class_list": "",
        "function": "May have a role in protein folding or as a chaperone., [UniProtKB]; This gene encodes a member of the DnaJ heat shock protein family. The encoded protein, which contains a conserved N-terminal DnaJ domain, is thought to play a role in protein folding or act as a molecular chaperone protein. [provided by RefSeq, Oct 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DSF2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "GO:0001659 temperature homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q9NX36-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NY33-1",
        "uniprot_id": "DPP3_HUMAN",
        "mass": 82589.0,
        "length": 737,
        "protein_name": "Dipeptidyl peptidase 3",
        "gene_name": "DPP3",
        "organism": "Human",
        "refseq_name": "dipeptidyl peptidase 3 isoform 2",
        "refseq_ac": "NP_001243599",
        "gene_names_uniprotkb": "DPP3",
        "gene_names_refseq": "DPP3; DPPIII",
        "protein_names_uniprotkb": "Dipeptidyl peptidase 3; 3.4.14.4; DPP III; Dipeptidyl aminopeptidase III; Dipeptidyl arylamidase III; Dipeptidyl peptidase III; Enkephalinase B",
        "protein_names_refseq": "DPP III; dipeptidyl aminopeptidase III; dipeptidyl arylamidase III; dipeptidyl peptidase 3 isoform 2; dipeptidyl peptidase III; enkephalinase B",
        "tax_id": 9606,
        "disease": "lysosomal acid lipase deficiency (Disease Ontology:DOID:0080217); Wolman disease (Disease Ontology:DOID:14497); cholesterol ester storage disease (Disease Ontology:DOID:14502)",
        "pathway": " (hsa:10072);  (R-HSA-8951664);  (R-HSA-9755511)",
        "pathway_count": 3,
        "publication_count": 207,
        "publication_id_list": "10.1101/2023.09.13.557529;10535940;10597293;10811609;10878807;10973499;11069780;11209758;11237011;11259415;11292861;11292862;11454738;11585840;11733065;11961546;12101228;12186903;12198130;12504025;12504026;12526791;12538644;12609982;12682069;12700136;12759363;12816948;14517290;14585973;14688281;14690597;14757770;14759258;14764894;1515063;15282312;15361859;15367669;15537541;15572695;15574592;15601839;15652483;15688063;15694336;15799966;15983046;16171779;16286508;16359182;16401342;16547496;16647857;16707496;16790436;16943200;16962933;17081101;17132228;17183367;17220875;17332328;17497243;17512459;17785452;17979524;18093314;18206966;18238777;18273910;18775313;18776931;18805092;18826954;18851830;18926707;19250909;19321346;19617556;19748355;20378532;20452972;20495340;21220506;21391649;21447816;21463634;21734707;21778237;21863050;21940857;22223895;22306028;22466964;22493238;22537386;22789539;22872865;22959436;23201271;23274085;23333871;23401859;23453757;23535662;23535663;23563313;23583660;23912815;23986495;24011591;24076655;24298019;24366543;24636985;24715725;24793695;24793696;25040165;25314029;25349211;25355947;25505266;25531226;25793262;25810538;25880248;25921531;26117325;26344709;26460955;26583321;26632597;26906416;26942676;27030794;27222660;27565346;27920218;28115426;28228285;28380357;28510447;28514659;28832583;28904123;29153394;29233872;29242379;29314611;29450944;29526543;29557506;30379171;30610225;30779550;30833945;31020640;31217245;31530632;31546975;31844290;32005965;32157095;32161166;32284348;32293500;3233187;32350084;32357974;32387766;32502341;32640524;32672401;32983136;33009401;33043033;33444648;33592498;33791708;33859744;33912179;33936100;33968037;34087483;34171305;34229054;34357683;34725712;35051231;35154160;35251023;35561310;35580925;36241641;37531267;37628928;37733154;38655619;38665916;39442988;40914422;9425109;9790970;9887101;9891082",
        "class_list": "",
        "function": "Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and promoting lipid synthesis., [RefSeq, PubMed]; Dipeptidyl-peptidase 3 and IL-6: potential biomarkers for diagnostics in COVID-19 and association with pulmonary infiltrates., [RefSeq, PubMed]; Identification of an Additional Metal-Binding Site in Human Dipeptidyl Peptidase III. Publication Status: Online-Only, [RefSeq, PubMed]; Involvement of DPP3 in modulating oncological features and oxidative stress response in esophageal squamous cell carcinoma., [RefSeq, PubMed]; This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]., [RefSeq]; [Dipeptidyl peptidase 3 (DPP3) inhibits immune escape of gastric cancer cells through down-regulation of major histocompatibility complex class I chain-related gene B (MICB) expression]., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDB5;B4DLX4;F5H8L6;O95748;Q969H2;Q9BV67;Q9HAL6",
        "ec_number_list": "2.3.2.27;2.3.2.32;3.4.14.4",
        "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0008235 metalloexopeptidase activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 21.2,
        "record_id": "Q9NY33-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9P1J3-1",
        "uniprot_id": "DHAS1_HUMAN",
        "mass": 7343.0,
        "length": 65,
        "protein_name": "Putative uncharacterized protein DHRS4-AS1",
        "gene_name": "DHRS4-AS1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DHRS4-AS1; C14orf167; PRO1488",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative uncharacterized protein DHRS4-AS1; DHRS4 antisense RNA 1; DHRS4 antisense gene protein 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "Q9P1J3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9P2K9-1",
        "uniprot_id": "DISP3_HUMAN",
        "mass": 153048.0,
        "length": 1392,
        "protein_name": "Protein dispatched homolog 3",
        "gene_name": "DISP3",
        "organism": "Human",
        "refseq_name": "protein dispatched homolog 3",
        "refseq_ac": "NP_065831",
        "gene_names_uniprotkb": "DISP3; KIAA1337; PTCHD2",
        "gene_names_refseq": "DISP3; PTCHD2",
        "protein_names_uniprotkb": "Protein dispatched homolog 3; Patched domain-containing protein 2",
        "protein_names_refseq": "dispatched 3; dispatched homolog 3; patched domain containing 2; patched domain-containing protein 2; protein dispatched homolog 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57540)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "10.1101/2023.09.13.557529;15645143;19179482;25041255;25281927;28134287;28904123;29557506;30379171;32387766;32938616;35051231;35580925",
        "class_list": "",
        "function": "Impact of DISP3 on the proliferation and differentiation of neural precursors, [RefSeq, PubMed]; Our findings imply that DISP3 may help dictate the NSC cell fate to either undergo self-renewal or switch to the terminal differentiation cell program. Publication Status: Online-Only, [RefSeq, PubMed]; Patched domain containing 2 (PTCHD2), yielded a statistically significant P-value of 2.5 x 10(-6) (OR = 0.27) with fewer individuals classified as exhibiting symptoms of dependence to ultraviolet light, a known carcinogen, in the context of tanning, [RefSeq, PubMed]; Plays a role in neuronal proliferation and differentiation (PubMed:25281927). Plays a role in the accumulation of cellular cholesterol (By similarity). Involved in intracellular lipid droplet formation (PubMed:25281927). May contribute to cholesterol homeostasis in neuronal cells (By similarity)., [UniProtKB, PubMed, UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 61,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VTU9;Q9UJD6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0032368 regulation of lipid transport;GO:0045834 positive regulation of lipid metabolic process;GO:0008203 cholesterol metabolic process;GO:0030154 cell differentiation;GO:0045665 negative regulation of neuron differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q9P2K9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UI46-1",
        "uniprot_id": "DNAI1_HUMAN",
        "mass": 79283.0,
        "length": 699,
        "protein_name": "Dynein axonemal intermediate chain 1",
        "gene_name": "DNAI1",
        "organism": "Human",
        "refseq_name": "dynein axonemal intermediate chain 1 isoform 2",
        "refseq_ac": "NP_001268357",
        "gene_names_uniprotkb": "DNAI1",
        "gene_names_refseq": "CILD1; DIC1; DNAI1; ICS1; PCD; oda6",
        "protein_names_uniprotkb": "Dynein axonemal intermediate chain 1; Axonemal dynein intermediate chain 1",
        "protein_names_refseq": "dynein axonemal intermediate chain 1 isoform 2; dynein, axonemal, intermediate polypeptide 1; immotile cilia syndrome 1; testis tissue sperm-binding protein Li 87P",
        "tax_id": 9606,
        "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); developmental and epileptic encephalopathy 26 (Disease Ontology:DOID:0080461); primary ciliary dyskinesia 1 (Disease Ontology:DOID:0110594); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); epilepsy (Disease Ontology:DOID:1826); primary ciliary dyskinesia (Disease Ontology:DOID:9562)",
        "pathway": " (hsa:27019)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "10577904;11231901;11237011;12509440;23664119;25186273;27120127;28939216;29393594;29557506;31772028;33139725;34445527;35051231;35580925;37217939;39894887",
        "class_list": "",
        "function": "A novel mutation causing primary ciliary dyskinesia was found in Japanese patients., [RefSeq, PubMed]; Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Part of the dynein complex of respiratory cilia., [UniProtKB, UniProtKB]; Component of dynein, a family of motor proteins essential for movement along microtubules. Required for structural and functional integrity of cilia. Part of the dynein complex of respiratory cilia., [UniProtKB, UniProtKB]; Deep phenotyping, including quantitative ciliary beating parameters, and extensive genotyping in primary ciliary dyskinesia., [RefSeq, PubMed]; Identification and Classification of Novel Genetic Variants: En Route to the Diagnosis of Primary Ciliary Dyskinesia. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 7,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z7U1;Q5T8G7;Q8NHQ7;Q9UEZ8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003774 cytoskeletal motor activity;GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005856 cytoskeleton;GO:0005874 microtubule;GO:0005929 cilium;GO:0036126 sperm flagellum",
        "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0008286 insulin receptor signaling pathway;GO:0007368 determination of left/right symmetry;GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q9UI46-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y2E6-1",
        "uniprot_id": "DTX4_HUMAN",
        "mass": 67258.0,
        "length": 619,
        "protein_name": "E3 ubiquitin-protein ligase DTX4",
        "gene_name": "DTX4",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase DTX4 isoform 2",
        "refseq_ac": "NP_001287656",
        "gene_names_uniprotkb": "DTX4; KIAA0937; RNF155",
        "gene_names_refseq": "DTX4; RNF155",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase DTX4; 2.3.2.27; Deltex4; Protein deltex-4; RING finger protein 155; RING-type E3 ubiquitin transferase DTX4",
        "protein_names_refseq": "E3 ubiquitin-protein ligase DTX4 isoform 2; E3 ubiquitin-protein ligase DTX4; RING finger protein 155; RING-type E3 ubiquitin transferase DTX4; deltex 4 homolog; deltex 4, E3 ubiquitin ligase; deltex homolog 4; deltex4; protein deltex-4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23220);  (R-HSA-1606341);  (R-HSA-2122948);  (R-HSA-3134975);  (R-HSA-3270619)",
        "pathway_count": 5,
        "publication_count": 99,
        "publication_id_list": "10.1074/mcp.M114.046862;10206645;10879540;10882063;11006133;11035028;11226752;11740940;11839743;12133833;12209127;12354787;12530964;12692549;14567914;15210742;15574878;15652348;15684394;15760269;15824097;15829515;15965470;16093323;16281057;16284625;16306936;17003037;17028573;17401372;17483521;17526488;17618271;18043734;18077452;18237417;18296446;18628966;18700817;18818105;18824583;18824585;19000840;19151708;19307177;19433799;19524514;19567869;19726682;19776740;19926846;21074459;21862588;22162134;22388039;22394562;22579474;22619329;22745133;23222971;23396211;23481700;24560620;24715725;25813380;26154972;27920218;28228285;28467828;28611181;28832583;29242379;29331515;29557506;29632046;29789417;30573663;30779550;31844290;31848261;31998317;32157095;32350084;32502341;33141586;33936100;34357683;35051231;37612343;8313469;9244301;9315665;9462510;9463386;9590294;9604939;9620803;9651681;9819428",
        "class_list": "",
        "function": "Deltex E3 ubiquitin ligase 4 promotes thyroid cancer progression through stearoyl-CoA desaturase 1. Publication Status: Online-Only, [RefSeq, PubMed]; Notch is ligand activated and undergoes DTX4-mediated ubiquitylation and bilateral endocytosis before ADAM10 processing Publication Status: Online-Only, [RefSeq, PubMed]; Our results provide molecular insight into the mechanisms by which NLRP4-DTX4 targets TBK1 for degradation. Publication Status: Online-Only, [RefSeq, PubMed]; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q0VF38",
        "ec_number_list": "3.4.23.-;2.3.2.27;2.3.2.26;2.7.11.1",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol",
        "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0010498 proteasomal protein catabolic process;GO:0070936 protein K48-linked ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 10.3,
        "record_id": "Q9Y2E6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y5R5-1",
        "uniprot_id": "DMRT2_HUMAN",
        "mass": 61814.0,
        "length": 561,
        "protein_name": "Doublesex- and mab-3-related transcription factor 2",
        "gene_name": "DMRT2",
        "organism": "Human",
        "refseq_name": "doublesex- and mab-3-related transcription factor 2 isoform 1",
        "refseq_ac": "NP_001124337",
        "gene_names_uniprotkb": "DMRT2; DSXL2",
        "gene_names_refseq": "DMRT2; DSXL-2; SCDO7",
        "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor 2; DSXL-2; Doublesex-like 2 protein",
        "protein_names_refseq": "doublesex- and mab-3-related transcription factor 2 isoform 1; doublesex-like 2 protein; terra-like protein",
        "tax_id": 9606,
        "disease": "intellectual disability (Disease Ontology:DOID:1059); azoospermia (Disease Ontology:DOID:14227)",
        "pathway": " (hsa:10655)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "10332030;10729224;10857744;11237011;29331515;29557506;31350341;31844290;31846834;32938616;33082515;33392160;34933911;35051231;35494241;37217939",
        "class_list": "",
        "function": "Long interspersed element-1 ribonucleoprotein particles protect telomeric ends in alternative lengthening of telomeres dependent cells., [RefSeq, PubMed]; Protein Phosphatase 2A-Dependent Mitotic hnRNPA1 Dephosphorylation and TERRA Formation Facilitate Telomere Capping., [RefSeq, PubMed]; Study confirms that TERRA corresponds to a large gene family transcribed from multiple chromosome ends where we identified two types of TERRA promoters, only one of which is regulated by DNA methylation, [RefSeq, PubMed]; TRF2 recruits nucleolar protein TCOF1 to coordinate telomere transcription and replication., [RefSeq, PubMed]; The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. [provided by RefSeq, Apr 2010]., [RefSeq]; Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1ANC0;B9EGJ1;Q9NPG6;Q9NQR6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007548 sex differentiation;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q9Y5R5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14184-1",
        "uniprot_id": "DOC2B_HUMAN",
        "mass": 45922.0,
        "length": 412,
        "protein_name": "Double C2-like domain-containing protein beta",
        "gene_name": "DOC2B",
        "organism": "Human",
        "refseq_name": "double C2-like domain-containing protein beta",
        "refseq_ac": "NP_003576",
        "gene_names_uniprotkb": "DOC2B; DOC2BL",
        "gene_names_refseq": "DOC2BL; DOC2B",
        "protein_names_uniprotkb": "Double C2-like domain-containing protein beta; Doc2-beta",
        "protein_names_refseq": "doc2-beta; double C2-like domain-containing protein beta; double C2-like domains, beta",
        "tax_id": 9606,
        "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)",
        "pathway": " (hsa:8447)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "11237011;17548353;21220648;22036572;24570007;27434670;27862975;29506054;29557506;30379171;30779550;31154438;32157095;35051231;35377441;36241641;36913987;37938771;8554557;9804756",
        "class_list": "",
        "function": "Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity)., [UniProtKB, PubMed]; Double C-2 like domain beta (DOC2B) induces calcium dependent oxidative stress to promote lipotoxicity and mitochondrial dysfunction for its tumor suppressive function., [RefSeq, PubMed]; Here the authors report that analogous ring-like oligomers assemble from the C2AB domains of other Syt isoforms (Syt2, Syt7, Syt9) as well as related C2 domain containing protein, Doc2B and extended Synaptotagmins (E-Syts). Publication Status: Online-Only, [RefSeq, PubMed]; Promoter hypermethylation and silencing of the DOC2B gene is an early and frequent event during cervical carcinogenesis and whose reduced expression due to DNA promoter methylation may lead to selective cervical tumor growth, [RefSeq, PubMed]; Reduction of DOC2B is an early feature of T1 diabetes (T1D), and DOC2B abundance may serve as a valuable in vivo indicator of beta-cell mass and an early biomarker of T1D., [RefSeq, PubMed]; Study analyzed Doc2alpha and Doc2beta and found that Doc2 responds to changes in [Ca2+], with markedly slower kinetics as compared to the cytosolic domain of syt I (syt), and operates on a timescale consistent with asynchronous neurotransmitter release., [RefSeq, PubMed]; There are at least two protein isoforms of the Double C2 protein,  namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains.  DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A087WZX8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0019905 syntaxin binding;GO:0005544 calcium-dependent phospholipid binding;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0098793 presynapse;GO:0016020 membrane",
        "go_biological_process": "GO:0032024 positive regulation of insulin secretion;GO:0008104 intracellular protein localization;GO:0031340 positive regulation of vesicle fusion;GO:0045956 positive regulation of calcium ion-dependent exocytosis;GO:0048791 calcium ion-regulated exocytosis of neurotransmitter",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q14184-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P01903-1",
        "uniprot_id": "DRA_HUMAN",
        "mass": 28621.0,
        "length": 254,
        "protein_name": "HLA class II histocompatibility antigen, DR alpha chain",
        "gene_name": "HLA-DRA",
        "organism": "Human",
        "refseq_name": "HLA class II histocompatibility antigen, DR alpha chain precursor",
        "refseq_ac": "NP_061984",
        "gene_names_uniprotkb": "HLA-DRA; HLA-DRA1",
        "gene_names_refseq": "HLA-DRA1; HLA-DRA",
        "protein_names_uniprotkb": "HLA class II histocompatibility antigen, DR alpha chain; MHC class II antigen DRA",
        "protein_names_refseq": "HLA class II histocompatibility antigen, DR alpha chain precursor; HLA class II histocompatibility antigen, DR alpha chain; MHC class II antigen DRA; histocompatibility antigen HLA-DR alpha",
        "tax_id": 9606,
        "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); prediabetes syndrome (Disease Ontology:DOID:11716); allergic disease (Disease Ontology:DOID:1205); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); bipolar disorder (Disease Ontology:DOID:3312); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); autoimmune thyroiditis (Disease Ontology:DOID:7188); hepatitis B virus, susceptibility to (MONDO:MONDO:0012488)",
        "pathway": " (hsa:3122);  (R-HSA-202424);  (R-HSA-202427);  (R-HSA-202430);  (R-HSA-202433);  (R-HSA-2132295);  (R-HSA-389948);  (R-HSA-877300)",
        "pathway_count": 8,
        "publication_count": 313,
        "publication_id_list": "10036229;10064083;10067896;10072072;10480952;10540230;10593899;10631941;10631952;10639150;10671560;10698680;10716940;10747096;10748235;10790433;10809954;10811803;10986460;11048639;11070170;11080454;11163233;11358993;11390650;11432818;11529500;11607830;11684289;11752630;11790530;11813165;11827988;11853874;11864610;11884229;11972023;12040185;12078484;12198549;12244309;12438563;12445311;12446674;12473184;12485116;12660731;12742663;12748383;12893276;12915721;12938237;12947224;1396683;14510693;14514672;14586410;14722222;14731593;14978097;15084594;1508672;15122200;15125833;15143187;15145317;15265931;15322115;15322540;15358536;15371334;15388922;15489910;15489916;15530433;15541657;15565337;15749704;15777939;15911768;16056267;16079912;16181339;16237089;16242130;16356853;16356855;16364187;16461343;16467876;16612002;16618111;16824007;16978534;17047224;17072321;17125875;17135271;17142755;17182262;17283181;17334368;17363905;17468049;17496917;17548359;17583734;17652306;17728323;18046453;18173375;18292509;18305173;18362138;18507432;18591661;18697946;18759926;18991276;19117940;19159218;1956401;19564404;20049711;20130243;20304997;20346773;20363976;21081917;21115828;21116285;21154117;2121367;21441454;21543337;2190094;21972290;2210803;2212658;22299025;22327072;22426112;23061660;23260142;23302904;23580664;23783831;2391366;24190431;24190977;24417533;2530588;25413013;25418920;25576301;25645385;25892735;2658055;26740625;27114505;27452731;27591323;27600516;27920218;28165004;28218747;28228285;28265006;28649982;28832583;28834231;28860189;28871256;29242379;29314611;29317506;29393594;29508533;29632046;29632711;29741879;29774024;29786170;29789417;29863979;29884618;30315122;30429286;30522017;30524438;30573663;30626607;31092671;31154438;31313098;31495665;31530632;31619516;31844290;31848261;31937595;31998317;32157095;32162841;32350084;32488085;32668259;32897882;32938616;32983136;33043033;33239784;33298915;33592498;33691108;33717175;33912179;33936100;33968037;34078123;34087483;34211107;34357683;34433824;34561969;34858413;34932366;35051231;35154160;35318648;35543859;35561310;35580925;35794593;35895219;36215666;36284347;37074911;37938771;38942763;6304715;6324094;6416803;6600932;6811954;6812963;6821129;6955253;7477400;7479848;7479981;7481823;7510216;7514165;7530745;7565724;7592972;7615558;7617032;7650016;7657660;7667286;7673114;7690989;7796299;8046351;8134367;8145819;8148318;8152483;8156998;8176225;8313912;8315383;8316295;8397411;8415765;8483949;8520027;8530158;8550590;8550631;8601309;8606061;8631301;8642258;8687433;8798379;8824201;8849454;8909537;8939989;8947036;9075930;9111318;9115214;9143706;9202021;9252186;9311912;9312039;9321428;9354468;9362451;9497313;9539769;9545226;9606180;9687533;9782128;9846482;9850860;9990853",
        "class_list": "",
        "function": "An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells (PubMed:15265931, PubMed:15322540, PubMed:17334368, PubMed:22327072, PubMed:24190431, PubMed:27591323, PubMed:29884618, PubMed:31495665, PubMed:8145819, PubMed:9075930). Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:8145819). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (PubMed:31495665). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (PubMed:17182262, PubMed:23783831). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides (PubMed:25413013). The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (PubMed:8145819)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with APOE E4 to alter risk for late onset Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Combination of HLA-DR on Mycobacterium tuberculosis-Specific Cells and Tuberculosis Antigen/Phytohemagglutinin Ratio for Discriminating Active Tuberculosis From Latent Tuberculosis Infection. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer., [RefSeq, PubMed]; Genetic polymorphism of HLA-DRA and alcohol consumption affect hepatitis development in the Korean population., [RefSeq, PubMed]; HLA class II molecule HLA-DRA identifies immuno-hot tumors and predicts the therapeutic response to anti-PD-1 immunotherapy in NSCLC. Publication Status: Online-Only, [RefSeq, PubMed]; HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by presenting peptides derived from extracellular proteins, in particular, pathogen-derived peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Aug 2020]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 3,
        "reported_phosphosites": 0,
        "reported_mutagensis": 20,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 88,
        "disease_count": 12,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2BET4;Q30160;Q6IAZ1;Q861I2;Q9TP70",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding;GO:0042608 T cell receptor binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0032588 trans-Golgi network membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0045622 regulation of T-helper cell differentiation;GO:0006955 immune response;GO:0050890 cognition;GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II",
        "synthesized_glycan_count": 0,
        "hit_score": 40.6,
        "record_id": "P01903-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P13765-1",
        "uniprot_id": "DOB_HUMAN",
        "mass": 30822.0,
        "length": 273,
        "protein_name": "HLA class II histocompatibility antigen, DO beta chain",
        "gene_name": "HLA-DOB",
        "organism": "Human",
        "refseq_name": "HLA class II histocompatibility antigen, DO beta chain precursor",
        "refseq_ac": "NP_002111",
        "gene_names_uniprotkb": "HLA-DOB",
        "gene_names_refseq": "DOB; HLA-DOB; HLA_DOB",
        "protein_names_uniprotkb": "HLA class II histocompatibility antigen, DO beta chain; MHC class II antigen DOB",
        "protein_names_refseq": "HLA class II histocompatibility antigen, DO beta chain precursor; HLA class II histocompatibility antigen, DO beta chain; MHC class II antigen DOB",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3112);  (R-HSA-2132295)",
        "pathway_count": 2,
        "publication_count": 120,
        "publication_id_list": "10036229;10064083;10072072;10480952;10540230;10593899;10631941;10631952;10639150;10748235;10809954;10837054;11237011;11529500;11684289;11790530;11813165;11853874;12078484;12198549;12445321;12742663;12748383;1453454;14731593;15749704;15911768;16181339;16242130;16618111;16824007;17142755;17283181;18046453;18292509;1956401;19564404;21116285;2121367;21441454;21654843;2190094;23400868;23481700;23783831;2391366;24190977;2499532;25418920;25502872;25548167;25645385;25874709;26375851;26992070;27846572;27920218;28218747;28228285;28813660;28832583;28834231;29242379;29393594;29508533;29557506;29632046;29632711;29786170;29789417;2998758;30315122;3036827;31154438;31844290;32157095;32350084;32357974;32502341;32938616;32983136;33043033;33592498;33691108;33717175;33936100;34185709;34433824;35051231;35154160;35561310;35580925;36389712;37855981;7481823;7592972;7650016;7667286;8046351;8134367;8145819;8148318;8313912;8397411;8415765;8568858;8642258;8687433;8849454;8909537;8939989;8947036;9075930;9202021;9311912;9312039;9497313;9539769;9545226;9606180",
        "class_list": "",
        "function": "HLA-DO beta-chain antigens are ubiquitinated by MARCH family E3 ligases 1, 8, and 9., [RefSeq, PubMed]; HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]., [RefSeq]; Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM., [UniProtKB]; MUC22, HLA-A, and HLA-DOB variants and COVID-19 in resilient super-agers from Brazil. Publication Status: Online-Only, [RefSeq, PubMed]; Potential role of SNP rs2071475 in rheumatoid arthritis and inflammatory bowel disease in the East Asian population: a Mendelian randomization study., [RefSeq, PubMed]; Results indicate that HLA-DOB is co-inherited with DQA2-B2 genes and thus may contribute to HCV and HBV persistence, [RefSeq, PubMed]; TAP2, HLA-DOA, HLA-DOB, and tapasin loci are novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0V0Y0;Q29746;Q29825;Q6FHC2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding;GO:0032395 MHC class II receptor activity",
        "go_cellular_component": "GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0042613 MHC class II protein complex;GO:0010008 endosome membrane",
        "go_biological_process": "GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0002250 adaptive immune response;GO:0050870 positive regulation of T cell activation;GO:0050778 positive regulation of immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 12.2,
        "record_id": "P13765-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0AVK6-1",
        "uniprot_id": "E2F8_HUMAN",
        "mass": 94166.0,
        "length": 867,
        "protein_name": "Transcription factor E2F8",
        "gene_name": "E2F8",
        "organism": "Human",
        "refseq_name": "transcription factor E2F8",
        "refseq_ac": "NP_001243300",
        "gene_names_uniprotkb": "E2F8",
        "gene_names_refseq": "E2F-8; E2F8",
        "protein_names_uniprotkb": "Transcription factor E2F8; E2F-8",
        "protein_names_refseq": "E2F family member 8; transcription factor E2F8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79733);  (R-HSA-6804116)",
        "pathway_count": 2,
        "publication_count": 77,
        "publication_id_list": "10891498;11237011;11812999;12692263;14580351;14633988;15133492;15722552;15897886;16179649;17719541;18194653;18202719;18220336;20817677;22172947;22802528;22802529;22903062;23064264;23186163;23481700;24715725;25576301;26992070;27452520;27920218;28063628;28228285;28446606;28832583;29242379;29393594;29485866;29493099;29508533;29632046;29769354;29786170;31092671;31217245;31844290;31995441;32157095;32502341;32897882;32938616;32938750;33141586;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34357683;35051231;35132862;35254053;35561310;35580925;36010968;36241641;37635486;37863324;37888771;38661062;38795825;39531497;39534244;8242752;9780002",
        "class_list": "",
        "function": "Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK-dependent manner., [RefSeq, PubMed]; E2F7 and E2F8 act upstream of E2F1, and influence the ability of cells to undergo a DNA-damage response., [RefSeq, PubMed]; E2F8 exerts cancer-promoting effects by transcriptionally activating RRM2 and E2F8 knockdown synergizes with WEE1 inhibition in suppressing lung adenocarcinoma., [RefSeq, PubMed]; E2F8 knockdown suppresses cell proliferation and induces cell cycle arrest via Wnt/beta-Catenin pathway in ovarian cancer., [RefSeq, PubMed]; E2F8 may have an important role in repressing the expression of E2F-target genes in the S-phase of the cell cycle. Publication Status: Online-Only, [RefSeq, PubMed]; ENO1 promotes trophoblast invasion regulated by E2F8 in recurrent miscarriage., [RefSeq, PubMed]; TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta., [RefSeq, PubMed]; The similarities between E2F-7 and E2F-8 define a new subgroup of the E2F family, and further imply that E2F-7 and E2F-8 may act through overlapping mechanisms in mediating cell cycle control., [RefSeq, PubMed]; This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 42,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K9H3;Q2VPJ3;Q3C1U6;Q5BKY4;Q8N340;Q9H5M0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex",
        "go_biological_process": "GO:0032877 positive regulation of DNA endoreduplication;GO:0033301 cell cycle comprising mitosis without cytokinesis;GO:0060718 chorionic trophoblast cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "A0AVK6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A8MZ26-1",
        "uniprot_id": "EFCB9_HUMAN",
        "mass": 23937.0,
        "length": 197,
        "protein_name": "EF-hand calcium-binding domain-containing protein 9",
        "gene_name": "EFCAB9",
        "organism": "Human",
        "refseq_name": "EF-hand calcium-binding domain-containing protein 9",
        "refseq_ac": "NP_001164654",
        "gene_names_uniprotkb": "EFCAB9",
        "gene_names_refseq": "EFCAB9",
        "protein_names_uniprotkb": "EF-hand calcium-binding domain-containing protein 9",
        "protein_names_refseq": "EF-hand calcium-binding domain-containing protein 9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:285588)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "29557506",
        "class_list": "",
        "function": "Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. pH-dependent Ca(2+) sensor required to activate the CatSper channel. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Associates with the CatSper complex via direct interaction with CATSPERZ, and senses intracellular Ca(2+). Together with CATSPERZ, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel., [UniProtKB, UniProtKB]; This gene encodes a protein with a C-terminal EF-hand calcium-binding domain similar to that found in penta-EF-hand (PEF) protein family members. The EF-hand is a helix-loop-helix structure with a canonical twelve-residue sequence that coordinates a calcium molecule with pentagonal bipyramidal symmetry. [provided by RefSeq, Jul 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0061891 calcium ion sensor activity",
        "go_cellular_component": "GO:0036128 CatSper complex;GO:0005737 cytoplasm;GO:0097228 sperm principal piece",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0048240 sperm capacitation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "A8MZ26-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86XF0-1",
        "uniprot_id": "DYR2_HUMAN",
        "mass": 21620.0,
        "length": 187,
        "protein_name": "Dihydrofolate reductase 2, mitochondrial",
        "gene_name": "DHFR2",
        "organism": "Human",
        "refseq_name": "dihydrofolate reductase 2, mitochondrial",
        "refseq_ac": "NP_001182572",
        "gene_names_uniprotkb": "DHFR2; DHFRL1; DHFRP4",
        "gene_names_refseq": "DHFR2; DHFRL1; DHFRP4",
        "protein_names_uniprotkb": "Dihydrofolate reductase 2, mitochondrial; 1.5.1.3; Dihydrofolate reductase, mitochondrial; Dihydrofolate reductase-like protein 1",
        "protein_names_refseq": "dihydrofolate reductase 2, mitochondrial; dihydrofolate reductase like 1; dihydrofolate reductase pseudogene 4; dihydrofolate reductase, mitochondrial; dihydrofolate reductase-like protein 1; hDHFR-psi 4",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:200895);  (R-HSA-196757)",
        "pathway_count": 2,
        "publication_count": 87,
        "publication_id_list": "10091649;10347183;10978331;11237011;12937168;16171773;17129779;17308042;17962486;18447718;19424049;19948730;20498374;21163947;21238436;21876184;21876188;2248959;23409799;23934049;24122410;24733394;25576301;25645385;25880248;25980602;2605182;26375851;27600516;27846572;27862975;28228285;28832583;28834231;28904123;29242379;29393594;29493099;29557506;29632046;30315122;30429286;30524438;3053686;30779550;30833945;31092671;31154438;31222486;31530632;31844290;31848261;32157095;32265295;32357974;32423175;32658475;32897882;32983136;33053560;33163492;33544972;33592498;33691108;33912179;33968037;33981976;34171305;34185709;34509645;34932366;35051231;35580925;36010968;36241641;36284347;3801490;38224738;3871768;4066659;6323448;7726158;7852378;8218174;8522195;8662720;9753690",
        "class_list": "",
        "function": "A dihydrofolate reductase 2 (DHFR2) variant is associated with risk of neural tube defects in an Irish cohort but not in a United Kingdom cohort., [RefSeq, PubMed]; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR., [UniProtKB, PubMed, PubMed]; The DHFRP4, or dihydrofolate reductase-like 1 (DHFRL1), gene is expressed and shares some commonalities with DHFR., [RefSeq, PubMed]; The Differential Translation Capabilities of the Human DHFR2 Gene Indicates a Developmental and Tissue-Specific Endogenous Protein of Low Abundance., [RefSeq, PubMed]; The results of this study suggest that genetic variants of methionine metabolism are associated with meningioma formation, [RefSeq, PubMed]; We hope this work will be useful to understand the general characteristics of DHFRL1., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DN30;Q6P4I9",
        "ec_number_list": "1.5.1.3",
        "go_molecular_function": "GO:0004146 dihydrofolate reductase activity;GO:0003729 mRNA binding;GO:0050661 NADP binding;GO:0033560 folate reductase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005829 cytosol",
        "go_biological_process": "GO:0046105 thymidine biosynthetic process;GO:0046654 tetrahydrofolate biosynthetic process;GO:0006730 one-carbon metabolic process;GO:0046655 folic acid metabolic process;GO:0046653 tetrahydrofolate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 8.8,
        "record_id": "Q86XF0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00418-1",
        "uniprot_id": "EF2K_HUMAN",
        "mass": 82144.0,
        "length": 725,
        "protein_name": "Eukaryotic elongation factor 2 kinase",
        "gene_name": "EEF2K",
        "organism": "Human",
        "refseq_name": "eukaryotic elongation factor 2 kinase",
        "refseq_ac": "NP_037434",
        "gene_names_uniprotkb": "EEF2K",
        "gene_names_refseq": "CaMKIII; EEF2K; HSU93850; eEF-2K",
        "protein_names_uniprotkb": "Eukaryotic elongation factor 2 kinase; 2.7.11.20; Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; eEF-2 kinase; eEF-2K",
        "protein_names_refseq": "alternative protein EEF2K; calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase; calmodulin-dependent protein kinase III; eEF-2 kinase; elongation factor-2 kinase; eukaroytic elongation factor 2 kinase; eukaryotic elongation factor 2 kinase",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); lung adenocarcinoma (Disease Ontology:DOID:3910)",
        "pathway": " (hsa:29904);  (R-HSA-166208)",
        "pathway_count": 2,
        "publication_count": 106,
        "publication_id_list": "10654941;11015200;11171059;11237011;11500363;11500364;12150926;12171600;12742462;14684180;14709557;15024086;15144186;15314020;15809305;16964243;17081983;1715244;17287340;17322306;17344846;18337751;18669648;18767875;19413330;19415658;19651622;19664994;19664995;19690332;20068231;20472894;20837011;21112387;21406692;21602892;22115317;22216903;22223895;22329831;22669845;22749997;23182879;23186163;23301498;23481700;24275569;24714562;24715725;25576301;25670349;25880248;26154972;26375851;26728094;26992070;27846572;27920218;27956550;28218747;28228285;28649982;28832583;28834231;28904123;29242379;29437277;29493099;29508533;29557506;29632711;29769354;30315122;30410026;30429286;30524438;31217245;31844290;32054489;32157095;32357974;32387766;32502341;32897882;32938616;33141586;33298915;33717175;33912179;33936100;33981976;34087483;34211107;34352439;34796967;34932366;35051231;35318648;35347072;35580925;35718922;36010968;36241641;37172726;9144159;9721431",
        "class_list": "",
        "function": "EEF2K as a novel metastatic and prognostic biomarker in gastric cancer patients., [RefSeq, PubMed]; EEF2K promotes PD-L1 stabilization through inactivating GSK3beta in melanoma., [RefSeq, PubMed]; MiRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K., [RefSeq, PubMed]; Roles of eukaryotic elongation factor 2 kinase (eEF2K) in neuronal plasticity, cognition, and Alzheimer disease. Review article, [RefSeq, PubMed]; Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor., [RefSeq, PubMed]; This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]., [RefSeq]; Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 64,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N588",
        "ec_number_list": "2.7.11.20",
        "go_molecular_function": "GO:0004686 elongation factor-2 kinase activity;GO:0004672 protein kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0043197 dendritic spine",
        "go_biological_process": "GO:0071454 cellular response to anoxia;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:1990637 response to prolactin;GO:0002931 response to ischemia;GO:0032869 cellular response to insulin stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 10.9,
        "record_id": "O00418-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P13639-1",
        "uniprot_id": "EF2_HUMAN",
        "mass": 95338.0,
        "length": 858,
        "protein_name": "Elongation factor 2",
        "gene_name": "EEF2",
        "organism": "Human",
        "refseq_name": "elongation factor 2",
        "refseq_ac": "NP_001952",
        "gene_names_uniprotkb": "EEF2; EF2",
        "gene_names_refseq": "EEF-2; EEF2; EF-2; EF2; SCA26",
        "protein_names_uniprotkb": "Elongation factor 2; 3.6.5.-; EF-2",
        "protein_names_refseq": "elongation factor 2; epididymis secretory sperm binding protein; polypeptidyl-tRNA translocase",
        "tax_id": 9606,
        "disease": "spinocerebellar ataxia 26 (Disease Ontology:DOID:0050975); adenoid cystic carcinoma (Disease Ontology:DOID:0080202); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); glaucoma (Disease Ontology:DOID:1686); rectum adenocarcinoma (Disease Ontology:DOID:1996); colon adenocarcinoma (Disease Ontology:DOID:234); invasive ductal carcinoma (Disease Ontology:DOID:3008); brain glioblastoma multiforme (Disease Ontology:DOID:3073); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); borna disease (Disease Ontology:DOID:5154); lung small cell carcinoma (Disease Ontology:DOID:5409); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:1938);  (R-HSA-156902);  (R-HSA-5336415);  (R-HSA-5358493);  (R-HSA-6798695);  (R-HSA-8876725)",
        "pathway_count": 6,
        "publication_count": 260,
        "publication_id_list": "10.1101/2023.09.13.557529;10380706;10501844;10513815;10958351;11237011;11466336;11500363;12171600;12194824;12668662;12750860;14654843;1508200;15104674;15116427;15302935;15485916;15592455;1596361;16118227;16139798;16408927;164179;16901746;16964243;17074750;17081983;17287340;17322306;18188169;18212344;18369606;18614030;18627462;18669648;18767875;18991276;1922338;19413330;19417104;19608861;19651622;19664994;20068231;20166139;20305658;20559380;21136679;21209280;21406692;22069710;221484;22223895;22424782;22544926;2261989;22645359;22869377;22898188;23001565;23169644;23184662;23186163;23301498;23349634;23468660;23481700;23486472;23555621;23636399;23645155;23650620;23971743;24029068;24366607;24397554;24422557;24589652;24648518;24714562;24715725;24739148;25064856;25114211;25144183;25231979;25352115;25367160;25416781;25418920;25469497;25502872;25505266;25576301;25645385;25802875;25810538;25880248;25892735;2610926;26154972;26304717;26375851;26545399;26552660;26593721;26728094;26758079;26768311;26811146;26853435;26929215;26992070;27115996;27397612;27543614;27600516;27846572;27862975;27920218;27956550;28063628;28218747;28228285;2840927;28446606;28467828;28514659;2862151;28649982;28832583;28834231;28855257;28860189;28904123;29242379;29314611;29317506;29331515;29371260;29393594;29435015;29437277;29493099;29508533;29557506;29632046;29632711;29731959;29769354;29786170;29789417;29930882;30001391;30315122;30355441;30397120;30410026;30429286;30484775;30524438;30573663;30779550;30833945;31020640;31092671;31154438;31217245;31222486;31530632;31611695;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32687489;32897882;32938616;32983136;33043033;33123756;33141586;33214551;33298915;33392160;3346227;33465208;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34087483;34093574;34171305;34185709;34211107;34357683;34405274;34433824;34509645;34561969;34705524;34725712;34932366;35008409;35051231;35083852;35132862;35138101;35154160;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36520140;36581221;37084140;37209825;37217939;37938771;38665916;39990658;40596516;40914422;4326212;5022429;5545092;6568109;7000782;7430147;7462325;7672826;8194524;8367482;8386634;8407925;8692836;9133370;9634482",
        "class_list": "",
        "function": "Analysis of senescence-responsive stress fiber proteome reveals reorganization of stress fibers mediated by elongation factor eEF2 in HFF-1 cells., [RefSeq, PubMed]; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721)., [UniProtKB, PubMed]; EEF2 improves dense connective tissue repair and healing outcome by regulating cellular death, autophagy, apoptosis, proliferation and migration. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of a novel recurrent EEF2 gene amplification in familial prostate tumors., [RefSeq, PubMed]; The FAM86 domain of FAM86A confers substrate specificity to promote EEF2-Lys525 methylation., [RefSeq, PubMed]; This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 16,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A384N6H1;B2RMP5;D6W618;Q58J86",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;3.4.19.12;3.6.4.13;2.7.1.35;3.6.1.5;1.1.1.42;2.4.2.1;3.4.21.46;1.16.3.1;1.11.1.6;4.1.2.13;2.4.1.1;5.3.1.9;5.1.3.-;3.4.23.5;3.4.22.52;2.4.2.7;3.4.22.1;3.6.4.10;3.2.1.31;2.5.1.18;2.7.10.2;1.13.11.-;1.13.11.34;3.3.2.6;3.4.11.4;1.11.1.7;1.1.1.205;4.2.99.18;5.6.2.4;4.2.1.24;3.4.19.1;5.3.2.1;5.3.3.12;2.7.11.1;2.7.1.40;3.4.24.35;3.1.6.14;3.1.6.12;3.2.1.23;2.7.1.11;5.4.2.11;5.4.2.4;2.7.4.6;2.7.13.3;3.4.22.27;2.7.11.24;3.5.4.5;3.6.1.-;5.4.2.2;2.4.1.186;2.7.1.1;2.7.1.-;2.3.3.8;3.6.4.6;3.6.5.4;5.2.1.8;3.1.1.47;3.1.1.-;3.5.4.6;1.11.1.24;2.7.11.39;3.5.1.23;3.5.1.-;3.5.1.109;2.7.11.22;2.7.11.23;2.3.2.5;6.3.1.14;2.3.2.26;3.6.-.-;3.6.1.6;5.4.2.7;2.1.1.-;3.4.25.1;3.6.1.15;3.1.1.97;2.5.1.108;2.1.1.314;2.3.2.27;3.4.18.1;3.6.1.42;4.1.2.4",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0051015 actin filament binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:2000767 positive regulation of cytoplasmic translation;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0002931 response to ischemia;GO:0003009 skeletal muscle contraction;GO:0045471 response to ethanol",
        "synthesized_glycan_count": 0,
        "hit_score": 26.9,
        "record_id": "P13639-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00148-1",
        "uniprot_id": "DX39A_HUMAN",
        "mass": 49130.0,
        "length": 427,
        "protein_name": "ATP-dependent RNA helicase DDX39A",
        "gene_name": "DDX39A",
        "organism": "Human",
        "refseq_name": "ATP-dependent RNA helicase DDX39A",
        "refseq_ac": "NP_005795",
        "gene_names_uniprotkb": "DDX39A; DDX39",
        "gene_names_refseq": "BAT1L; BAT1; DDX39A; DDX39; DDXL; URH49",
        "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX39A; 3.6.4.13; DEAD box protein 39; Nuclear RNA helicase URH49",
        "protein_names_refseq": "ATP-dependent RNA helicase DDX39A; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A; DEAD box protein 39; DEAD-box helicase 39A; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 39; UAP56-related helicase, 49 kDa; nuclear RNA helicase URH49; nuclear RNA helicase, DECD variant of DEAD box family",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10212);  (R-HSA-159236);  (R-HSA-72187)",
        "pathway_count": 3,
        "publication_count": 127,
        "publication_id_list": "10228171;10323864;10489353;10668806;11073998;11237011;11256625;11259411;11259602;11579093;11739738;11756420;11979277;12093754;12871933;14667819;15047853;15998806;16314397;16478985;17000901;17190602;17196963;17548965;17984224;18364396;18411249;18423201;18669648;18957205;19415658;19608861;19836239;20068231;20129943;20573985;20844015;21859714;21947206;22119546;22207203;22223895;22424782;22893130;22928037;22967762;23186163;23222130;23299939;23301498;23481700;23652018;23826332;24244187;24714562;25218447;25576301;25645385;25662211;25802875;25836925;25892735;26154972;26375851;26992070;27846572;27920218;28228285;28514659;28832583;28834231;28904123;29242379;29493099;29508533;29557506;29632711;29769354;29786170;29789417;30315122;30410026;30429286;30484775;30833945;31154438;31217245;31222486;31530632;31844290;31848261;31998317;32119511;32157095;32161166;32357974;32387766;32393512;32488085;32502341;32522876;32938616;33141586;33537174;33633747;33691108;33936100;33941617;33968037;34019948;34357683;34433824;34725712;35083852;35318648;35580925;36010968;36284347;37949067;38225262;38377942;38801080;39018261;39107495;40914422;9618489;9660949",
        "class_list": "",
        "function": "-dependent RNA helicase DDX39 has a role in poor prognosis of patients with gastrointestinal stromal tumor, [RefSeq, PubMed]; Data show that the two closely related RNA helicases UAP56 and URH49 have evolved to form distinct mRNA export machineries, which regulate mitosis at different steps., [RefSeq, PubMed]; Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing (PubMed:33941617, PubMed:38801080). Regulates nuclear mRNA export to the cytoplasm through association with ECD (PubMed:33941617). Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX (PubMed:39011894). Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression (PubMed:32393512). Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA (PubMed:37949067)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Intron Retention of DDX39A Driven by SNRPD2 is a Crucial Splicing Axis for Oncogenic MYC/Spliceosome Program in Hepatocellular Carcinoma., [RefSeq, PubMed]; Novel role for Ddx39 in differentiation and telomere length regulation of embryonic stem cells., [RefSeq, PubMed]; Parsing the roles of DExD-box proteins DDX39A and DDX39B in alternative RNA splicing., [RefSeq, PubMed]; RNA helicase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Regulation of URH49 mRNA expression and comparison with the related UAP56 RNA helicase. Publication Status: Online-Only, [RefSeq, PubMed]; Terminal regions of UAP56 and URH49 are required for their distinct complex formation functioning to an essential role in mRNA processing and export., [RefSeq, PubMed]; This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is thought to play a role in the prognosis of patients with gastrointestinal stromal tumors. A pseudogene of this gene is present on chromosome 13. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1Q2N1;Q8N5M0;Q9BVP6;Q9H5W0",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;2.7.7.19;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;2.7.1.78;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;3.1.27.-;2.7.4.3",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane",
        "go_biological_process": "GO:0046832 negative regulation of RNA export from nucleus;GO:0006406 mRNA export from nucleus;GO:0000398 mRNA splicing, via spliceosome;GO:0045824 negative regulation of innate immune response;GO:0006405 RNA export from nucleus",
        "synthesized_glycan_count": 0,
        "hit_score": 13.0,
        "record_id": "O00148-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00341-1",
        "uniprot_id": "EAA5_HUMAN",
        "mass": 60658.0,
        "length": 560,
        "protein_name": "Excitatory amino acid transporter 5",
        "gene_name": "SLC1A7",
        "organism": "Human",
        "refseq_name": "excitatory amino acid transporter 5 isoform 2",
        "refseq_ac": "NP_001274525",
        "gene_names_uniprotkb": "SLC1A7; EAAT5",
        "gene_names_refseq": "AAAT; EAAT5; SLC1A7",
        "protein_names_uniprotkb": "Excitatory amino acid transporter 5; Retinal glutamate transporter; Solute carrier family 1 member 7",
        "protein_names_refseq": "excitatory amino acid transporter 5 (retinal glutamate transporter); excitatory amino acid transporter 5 isoform 2; solute carrier family 1 (glutamate transporter), member 7",
        "tax_id": 9606,
        "disease": "episodic ataxia type 6 (Disease Ontology:DOID:0050994); neurodegenerative disease (Disease Ontology:DOID:1289); epilepsy (Disease Ontology:DOID:1826)",
        "pathway": " (hsa:6512);  (R-HSA-210500);  (R-HSA-9958863)",
        "pathway_count": 3,
        "publication_count": 30,
        "publication_id_list": "10440375;10620514;11001057;11015561;11237011;11242046;11756489;12519779;15737648;15935055;16116111;16616430;16959974;17478680;17891149;17989281;18215623;19086053;19913121;24578174;31154438;3214421;32173860;33968037;35051231;7521911;7791878;7859077;9108121;9701566",
        "class_list": "",
        "function": "Human brain neurons express a novel splice variant of excitatory amino acid transporter 5 (hEAAT5v)., [RefSeq, PubMed]; In conclusion, the kinases SGK1 and SGK3 increase EAAT5 activity by increasing cell surface abundance of the carrier., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:9108121). Acts primarily as an inhibitory glutamate-gated chloride channel being a major inhibitory presynaptic receptor at mammalian rod bipolar cell axon terminals. Glutamate binding gates a large Cl(-) conductance that mediates inhibition, affecting visual processing in the retina (By similarity)., [UniProtKB, PubMed, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VVZ0;Q969Z8;Q9BW45",
        "ec_number_list": "",
        "go_molecular_function": "GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0005314 high-affinity L-glutamate transmembrane transporter activity;GO:0015501 glutamate:sodium symporter activity;GO:0008068 extracellularly glutamate-gated chloride channel activity;GO:0005313 L-glutamate transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0098794 postsynapse;GO:0097060 synaptic membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0006865 amino acid transport;GO:1902476 chloride transmembrane transport;GO:0001504 neurotransmitter uptake;GO:0006836 neurotransmitter transport;GO:0015813 L-glutamate transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "O00341-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00716-1",
        "uniprot_id": "E2F3_HUMAN",
        "mass": 49162.0,
        "length": 465,
        "protein_name": "Transcription factor E2F3",
        "gene_name": "E2F3",
        "organism": "Human",
        "refseq_name": "transcription factor E2F3 isoform 2",
        "refseq_ac": "NP_001230005",
        "gene_names_uniprotkb": "E2F3; KIAA0075",
        "gene_names_refseq": "E2F-3; E2F3",
        "protein_names_uniprotkb": "Transcription factor E2F3; E2F-3",
        "protein_names_refseq": "transcription factor E2F3 isoform 2; transcription factor E2F3",
        "tax_id": 9606,
        "disease": "vertebral hypersegmentation and orofacial anomalies (Disease Ontology:DOID:0070418); myostatin-related muscle hypertrophy (Disease Ontology:DOID:0111072); prostate cancer (Disease Ontology:DOID:10283); hypothyroidism (Disease Ontology:DOID:1459); high grade glioma (Disease Ontology:DOID:3070); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); peripheral vascular disease (Disease Ontology:DOID:341); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); uremia (Disease Ontology:DOID:4676); congestive heart failure (Disease Ontology:DOID:6000); muscular atrophy (Disease Ontology:DOID:767)",
        "pathway": " (hsa:1871);  (R-HSA-1912408);  (R-HSA-2559580);  (R-HSA-2559585);  (R-HSA-68911);  (R-HSA-69231);  (R-HSA-9661069)",
        "pathway_count": 7,
        "publication_count": 219,
        "publication_id_list": "10207050;10347217;10358095;10385618;10499802;10722742;10772813;10831586;10871633;11032757;11073976;11157749;11231573;11234019;11416152;11564866;11719808;11782450;11883935;11884610;12134156;12189133;12193592;12421820;12435631;12435635;12444543;12808055;13130464;1423597;14507994;14517297;14532106;14597415;14729966;14991602;15287722;15469821;15472075;15563468;15572696;15579463;15684396;15716352;15866172;16186825;16195327;16211008;16337592;16436515;16612405;16782892;16826196;17092340;17210787;17254966;17254967;17254968;17255097;17332741;17344414;17344417;17395714;17540598;17540599;17554337;17685488;17765224;17823410;17825402;17875933;17908796;1826560;1828392;1828393;1828394;1831692;18365017;18414028;18710949;18793328;18827403;19075005;19150886;19451217;19451218;19458076;19462008;19487459;19528227;19714243;19723635;19773441;19917728;20080834;20090754;20107323;20351093;20442293;20442780;20495621;20534573;20663872;20801121;20805998;20843055;20952511;21280156;21402699;21423214;21551231;21602795;21715330;21875955;21986495;22020331;22110129;22325352;22336108;22683641;23007395;23622515;23737759;24515438;24876129;25576301;25645385;25733683;26768311;26921499;26977885;26992070;27846572;28832583;29101237;29242379;29508533;29557506;29786170;30429286;30484775;30524438;30711375;31154438;31543423;31844290;31848261;32157095;32161166;32357974;32387766;32488085;32938616;32983136;33298915;33537174;33592498;33691108;33912179;33968037;33981976;34087483;34171305;34509645;34932366;35051231;35580925;36010968;36241641;37775619;37938771;38194158;38380957;7535770;7588608;7588633;7797074;7816143;7859739;7954814;7958856;8001816;8033208;8078588;8114739;8139570;8246996;8259215;8319905;8336704;8413249;8497257;8552081;8622669;8622688;8626550;8741839;8774846;8846784;8878478;8974401;9030721;9042862;9106657;9144196;9162092;9190208;9195981;9325318;9342358;9447971;9448290;9508775;9529249;9564042;9628874;9693032;9768359;9824166",
        "class_list": "",
        "function": "FTO promotes the progression of retinoblastoma through YTHDF2-dependent N6-methyladenosine modification in E2F3., [RefSeq, PubMed]; MiR-210-3p enhances intermittent hypoxia-induced tumor progression via inhibition of E2F3., [RefSeq, PubMed]; This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]., [RefSeq]; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity)., [UniProtKB, UniProtKB]; Transcription factor E2F3 activates CDC25B to regulate DNA damage and promote mitoxantrone resistance in stomach adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 13,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q15000;Q68DT0;Q9BZ44",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex",
        "go_biological_process": "GO:0070345 negative regulation of fat cell proliferation;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000082 G1/S transition of mitotic cell cycle;GO:0006367 transcription initiation at RNA polymerase II promoter",
        "synthesized_glycan_count": 0,
        "hit_score": 22.0,
        "record_id": "O00716-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0CJ85-1",
        "uniprot_id": "DU4L2_HUMAN",
        "mass": 44926.0,
        "length": 424,
        "protein_name": "Double homeobox protein 4-like protein 2",
        "gene_name": "DUX4L2",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DUX4L2",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Double homeobox protein 4-like protein 2",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "P0CJ85-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0CJ90-1",
        "uniprot_id": "DU4L7_HUMAN",
        "mass": 44926.0,
        "length": 424,
        "protein_name": "Double homeobox protein 4-like protein 7",
        "gene_name": "DUX4L7",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DUX4L7",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Double homeobox protein 4-like protein 7",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "P0CJ90-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P12724-1",
        "uniprot_id": "ECP_HUMAN",
        "mass": 18385.0,
        "length": 160,
        "protein_name": "Eosinophil cationic protein",
        "gene_name": "RNASE3",
        "organism": "Human",
        "refseq_name": "eosinophil cationic protein precursor",
        "refseq_ac": "NP_002926",
        "gene_names_uniprotkb": "RNASE3; ECP; RNS3",
        "gene_names_refseq": "ECP; RAF1; RNASE3; RNS3",
        "protein_names_uniprotkb": "Eosinophil cationic protein; 3.1.27.-; ECP; RNase 3; Ribonuclease 3",
        "protein_names_refseq": "RNase 3; cytotoxic ribonuclease; eosinophil cationic protein precursor; eosinophil cationic protein; ribonuclease 3; ribonuclease, RNase A family, 3",
        "tax_id": 9606,
        "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156)",
        "pathway": " (hsa:6037);  (R-HSA-6798695);  (R-HSA-6803157)",
        "pathway_count": 3,
        "publication_count": 88,
        "publication_id_list": "37639587;10606511;10903870;11102386;11120840;11313366;11389039;11971875;12356310;12493837;13816;14506276;14739326;1522221;15229136;15778384;15826377;15956276;16054449;16215847;16336202;16354652;16354654;16374474;16799473;16931762;16940129;17363965;17502600;17567961;17964057;18021746;18160480;18185531;18673279;18694936;19095652;19179970;19254208;19450231;19818633;20103720;20180804;20382864;20395631;20510021;20690710;20845358;21787330;22262861;22327069;22455996;22701042;23302724;23426625;23650620;23716047;2387583;24219363;24256734;2473157;2501794;25075772;25461571;25596890;26148048;27089320;2745977;27893789;29557506;29789417;30315122;3286634;32983136;33091337;34515456;3458170;34615736;35051231;37938771;38033168;38563171;39259079;39894887;8692836;9523110;9665269;9756476",
        "class_list": "",
        "function": "Blood eosinophil cationic protein and eosinophil-derived neurotoxin are associated with different asthma expression and evolution in adults., [RefSeq, PubMed]; Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content., [UniProtKB, PubMed, PubMed]; Eosinophilic cationic protein (ECP) in the clinical work-up of chronic cough., [RefSeq, PubMed]; Exploring the role of eosinophil cationic protein (ECP) in schizophrenia: Insights and implications. Review article, [RefSeq, PubMed]; The antimicrobial protein, Rnase 3, contributes to the host immune response against mycobacteria., [RefSeq, PubMed]; The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]., [RefSeq]; Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are associated with Schistosoma mansoni worm burden in the Albert Nile region of Uganda. Publication Status: Online-Only, [RefSeq, PubMed]; [The auxiliary diagnostic value of ECP and MPO expression in nasal secretions in different types of rhinitis]., [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4VBC1;Q8WTP7;Q8WZ62;Q9GZN9",
        "ec_number_list": "4.6.1.19;3.2.1.24;1.6.2.2;3.2.1.51;3.5.3.1;1.11.2.2;3.2.1.-;3.2.1.22;3.4.21.4;3.2.1.52;3.2.1.31;3.4.21.37;3.4.21.20;4.6.1.18;3.4.16.5;3.4.16.-;2.4.1.1;3.1.27.-;3.1.6.8;3.1.6.14;3.1.6.12;3.2.1.23;1.1.1.205;3.5.1.26;3.4.21.76;2.7.11.24;1.11.1.27;3.1.1.4;2.3.1.23;3.1.6.4;2.7.10.2;3.6.1.-;2.3.3.8;3.4.14.1;3.6.4.6;3.2.1.17;2.7.11.13;6.3.4.21;1.8.4.-;5.3.4.1;3.4.19.9;1.6.5.5;3.1.3.16;5.3.99.3;3.5.4.4;3.4.14.2;3.5.3.15",
        "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0004519 endonuclease activity;GO:0004540 RNA nuclease activity;GO:0001530 lipopolysaccharide binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0035578 azurophil granule lumen",
        "go_biological_process": "GO:0006935 chemotaxis;GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium",
        "synthesized_glycan_count": 0,
        "hit_score": 9.3,
        "record_id": "P12724-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P21728-1",
        "uniprot_id": "DRD1_HUMAN",
        "mass": 49293.0,
        "length": 446,
        "protein_name": "D(1A) dopamine receptor",
        "gene_name": "DRD1",
        "organism": "Human",
        "refseq_name": "D(1A) dopamine receptor",
        "refseq_ac": "NP_000785",
        "gene_names_uniprotkb": "DRD1",
        "gene_names_refseq": "D1R; DADR; DRD1A; DRD1",
        "protein_names_uniprotkb": "D(1A) dopamine receptor; Dopamine D1 receptor",
        "protein_names_refseq": "D(1A) dopamine receptor; dopamine D1 receptor",
        "tax_id": 9606,
        "disease": "sinusitis (Disease Ontology:DOID:0050127); chorioamnionitis (Disease Ontology:DOID:0050697); alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); erythema nodosum (Disease Ontology:DOID:0080750); traumatic brain injury (Disease Ontology:DOID:0081292); leprosy (Disease Ontology:DOID:1024); bacterial infectious disease (Disease Ontology:DOID:104); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); hypertension (Disease Ontology:DOID:10763); adult respiratory distress syndrome (Disease Ontology:DOID:11394); allergic disease (Disease Ontology:DOID:1205); Graves' disease (Disease Ontology:DOID:12361); Huntington's disease (Disease Ontology:DOID:12858); Sjogren's syndrome (Disease Ontology:DOID:12894); typhoid fever (Disease Ontology:DOID:13258); pulmonary sarcoidosis (Disease Ontology:DOID:13406); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); cystitis (Disease Ontology:DOID:1679); melanoma (Disease Ontology:DOID:1909); hyperinsulinism (Disease Ontology:DOID:2018); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); high grade glioma (Disease Ontology:DOID:3070); tracheal stenosis (Disease Ontology:DOID:3227); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); cerebral infarction (Disease Ontology:DOID:3526); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); hyperglycemia (Disease Ontology:DOID:4195); pustulosis of palm and sole (Disease Ontology:DOID:4398); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); dermatitis herpetiformis (Disease Ontology:DOID:8505); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); psoriatic arthritis (Disease Ontology:DOID:9008); visceral leishmaniasis (Disease Ontology:DOID:9146); mucocutaneous leishmaniasis (Disease Ontology:DOID:9155); type 2 diabetes mellitus (Disease Ontology:DOID:9352); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)",
        "pathway": " (hsa:1812);  (R-HSA-390651);  (R-HSA-418555)",
        "pathway_count": 3,
        "publication_count": 73,
        "publication_id_list": "10618483;10739409;11007482;11773080;12036966;12058044;12106601;12180353;12860470;13549488;14060771;14671004;1517224;15765929;15769620;15951850;16313925;16687412;16923326;17168849;18044684;1826762;1840645;18577758;19105585;1975640;19876791;19929708;20381629;21036126;21179162;2129115;2144334;2163110;2168520;23936473;2417744;24687066;2491850;2532362;2553411;2553705;26182404;26417854;2871555;29443750;29557506;29602314;30833991;3127824;31279028;31399091;31844290;31983287;32226383;32497535;32540603;32618402;32715661;33049737;35051231;37024146;37252844;38302439;38572507;6085243;8340388;8471124;8514797;8672451;9263355;9417641;9651336",
        "class_list": "",
        "function": "DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons., [RefSeq, PubMed]; DRD1 suppresses cell proliferation and reduces EGFR activation and PD-L1 expression in NSCLC., [RefSeq, PubMed]; Dopamine D1-Receptor Organization Contributes to Functional Brain Architecture. Publication Status: Online-Only, [RefSeq, PubMed]; Dopamine Receptor D1 Is Exempt from Transforming Growth Factor beta-Mediated Antifibrotic G Protein-Coupled Receptor Landscape Tampering in Lung Fibroblasts., [RefSeq, PubMed]; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Forms heterotetramers with DRD3 to potentiate beta-arrestin recruitment and mediate locomotor activity., [UniProtKB, UniProtKB]; This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 52,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RA44;Q4QRJ0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004952 dopamine neurotransmitter receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0032795 heterotrimeric G-protein binding;GO:1990763 arrestin family protein binding;GO:0001965 G-protein alpha-subunit binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0005929 cilium",
        "go_biological_process": "GO:0051584 regulation of dopamine uptake involved in synaptic transmission;GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007617 mating behavior;GO:0008542 visual learning",
        "synthesized_glycan_count": 0,
        "hit_score": 7.4,
        "record_id": "P21728-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P60507-1",
        "uniprot_id": "EFC1_HUMAN",
        "mass": 65248.0,
        "length": 584,
        "protein_name": "Endogenous retrovirus group FC1 Env polyprotein",
        "gene_name": "ERVFC1",
        "organism": "Human",
        "refseq_name": "endogenous retrovirus group FC1 Env polyprotein",
        "refseq_ac": "XP_011529387",
        "gene_names_uniprotkb": "ERVFC1",
        "gene_names_refseq": "ERVFC1",
        "protein_names_uniprotkb": "Endogenous retrovirus group FC1 Env polyprotein; Envelope polyprotein; Fc1env; HERV-F(c)1_Xq21.33 provirus ancestral Env polyprotein; HERV-Fc1env",
        "protein_names_refseq": "endogenous retrovirus group FC1 Env polyprotein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:105373297)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11689652;12890629;12970426;14557543;23481700;28467828;31530632;35051231",
        "class_list": "",
        "function": "Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties., [UniProtKB, PubMed]; SU mediates receptor recognition., [UniProtKB]; TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity)., [UniProtKB]",
        "predicted_glycosites": 11,
        "predicted_n_glycosites": 11,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5JTS0",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "P60507-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q0D2K5-1",
        "uniprot_id": "EGFEM_HUMAN",
        "mass": 21632.0,
        "length": 195,
        "protein_name": "Putative EGF-like and EMI domain-containing protein 1",
        "gene_name": "EGFEM1P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "EGFEM1P; C3orf50; NCRNA00259",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative EGF-like and EMI domain-containing protein 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005044 scavenger receptor activity",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "Q0D2K5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13115-1",
        "uniprot_id": "DUS4_HUMAN",
        "mass": 42953.0,
        "length": 394,
        "protein_name": "Dual specificity protein phosphatase 4",
        "gene_name": "DUSP4",
        "organism": "Human",
        "refseq_name": "dual specificity protein phosphatase 4 isoform 1",
        "refseq_ac": "NP_001385",
        "gene_names_uniprotkb": "DUSP4; MKP2; VH2",
        "gene_names_refseq": "DUSP4; HVH2; MKP-2; MKP2; TYP",
        "protein_names_uniprotkb": "Dual specificity protein phosphatase 4; 3.1.3.16; 3.1.3.48; Dual specificity protein phosphatase hVH2; MAP kinase phosphatase 2; MKP-2; Mitogen-activated protein kinase phosphatase 2",
        "protein_names_refseq": "MAP kinase phosphatase 2; VH1 homologous phosphatase 2; dual specificity protein phosphatase 4 isoform 1; dual specificity protein phosphatase 4; dual specificity protein phosphatase hVH2; mitogen-activated protein kinase phosphatase 2; serine/threonine specific protein phosphatase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:1846);  (R-HSA-112409);  (R-HSA-202670);  (R-HSA-5675221)",
        "pathway_count": 4,
        "publication_count": 88,
        "publication_id_list": "10206983;10415025;10490027;10702794;10757792;12583813;14724641;15664191;15851477;16892053;17097642;17208316;17322878;17724343;18294816;18332145;18515281;18547165;19091743;19158341;19415758;19843478;20332238;20463170;21084841;21779496;22569528;22730326;23105109;23783831;24714562;24715725;25314968;25418920;25489052;25576301;25597358;25645385;25892735;26929215;27600516;27846572;27920218;28063628;28228285;28467828;28832583;28860189;29242379;29331515;29393594;29485866;29493099;29557506;29632046;29632711;29769354;29786170;30315122;30484775;31154438;31844290;31848261;32157095;32387766;32488085;32502341;32938616;33043033;33592498;33717175;33912179;33936100;33968037;34171305;34932366;35051231;35318648;35580925;36241641;36284347;38071325;38254666;38262246;38286920;38824257;7535768;8626452",
        "class_list": "",
        "function": "ARID1A loss activates MAPK signaling via DUSP4 downregulation. Publication Status: Online-Only, [RefSeq, PubMed]; DUSP4 maintains the survival and LSD1 protein stability in esophageal squamous cell carcinoma cells by inhibiting JNK signaling-dependent autophagy., [RefSeq, PubMed]; Dual specific phosphatase 4 suppresses ferroptosis and enhances sorafenib resistance in hepatocellular carcinoma., [RefSeq, PubMed]; Dual-Specificity Phosphatase 4 Promotes Malignant Features in Colorectal Cancer Through Cyclic-AMP Response Element Binding Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta Activation., [RefSeq, PubMed]; Proteomic Signaling of Dual-Specificity Phosphatase 4 (DUSP4) in Alzheimer's Disease. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2., [UniProtKB, PubMed]; The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RBU5;D3DSU4;G5E930;Q13524",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.21;3.1.3.18;3.1.3.-;3.1.3.5;3.1.3.2;2.7.11.24;2.7.10.1;3.1.3.67;3.1.3.53;2.7.11.22;3.1.3.52;3.1.3.27;3.1.3.86;3.1.3.36;3.1.3.74",
        "go_molecular_function": "GO:1990439 MAP kinase serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0016791 phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0016311 dephosphorylation;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0001706 endoderm formation",
        "synthesized_glycan_count": 0,
        "hit_score": 9.1,
        "record_id": "Q13115-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13217-1",
        "uniprot_id": "DNJC3_HUMAN",
        "mass": 57580.0,
        "length": 504,
        "protein_name": "DnaJ homolog subfamily C member 3",
        "gene_name": "DNAJC3",
        "organism": "Human",
        "refseq_name": "dnaJ homolog subfamily C member 3 isoform 1 precursor",
        "refseq_ac": "NP_006251",
        "gene_names_uniprotkb": "DNAJC3; P58IPK; PRKRI",
        "gene_names_refseq": "ACPHD; DNAJC3; ERdj6; HP58; P58IPK; P58; PRKRI; p58(IPK)",
        "protein_names_uniprotkb": "DnaJ homolog subfamily C member 3; ER-resident protein ERdj6; ERdj6; Endoplasmic reticulum DNA J domain-containing protein 6; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58",
        "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 3; ER-resident protein ERdj6; dnaJ homolog subfamily C member 3 isoform 1 precursor; endoplasmic reticulum DNA J domain-containing protein 6; interferon-induced, double-stranded RNA-activated protein kinase inhibitor; protein kinase inhibitor of 58 kDa; protein kinase inhibitor p58; protein-kinase, interferon-inducible double stranded RNA dependent inhibitor",
        "tax_id": 9606,
        "disease": "juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome (MONDO:MONDO:0014523)",
        "pathway": " (hsa:5611);  (R-HSA-192823);  (R-HSA-381038);  (R-HSA-381426);  (R-HSA-6798695);  (R-HSA-8957275);  (R-HSA-9833482);  (R-HSA-9918432)",
        "pathway_count": 8,
        "publication_count": 297,
        "publication_id_list": "10.1074/mcp.M114.046862;10026136;10077652;10082513;10218588;10228156;10348343;10400669;10512690;10601334;10614670;10620360;10626894;10648614;10681634;10810289;10827079;10848580;10866685;10898936;10912521;10951195;10990447;11096080;11134010;11152499;11156368;11158056;11237011;11238103;11238927;11250653;11264294;11278865;11313968;11316783;11337501;11350938;11438540;11500375;11522292;11606061;11726970;11739083;11751371;11781817;11788658;11909525;11939789;11985496;12204115;12231563;12241545;12379487;12397061;12466191;12601012;12810533;12882984;12904166;1370451;1373135;1383255;14585331;15126567;15229216;15299030;15308688;15466936;15469690;15485880;15525596;15642270;15737233;15752359;15907845;16179258;16179259;16373505;16431927;16461360;16539657;16600570;16630668;16717090;1695551;16982605;17047378;17079286;17196820;17249697;17312271;17985932;18096616;18664523;18835251;18957415;19229320;19416861;19710021;19733181;19804757;19838063;20395957;20519500;20685959;21072047;21123651;21282569;21294215;21518807;21636578;21799829;21937648;21978664;21994559;22214662;2247437;22986343;23084476;23229543;23481700;23555621;23650620;23732991;24347309;24623135;24659800;24715725;24753571;2476804;2479552;25418920;25466870;25469497;25505266;25645385;25653431;25813380;25848059;25880248;25892735;26091039;26208004;26375851;26432638;26446704;26488609;26716879;26817845;26992070;27208315;27269119;27383988;27423063;27543614;27600516;27846572;27862975;27920218;27974558;28063628;28069888;28167698;28228285;28228593;28281686;28765891;28832583;28904123;29170442;29175459;29231267;29242379;29331515;29348664;29393594;29394925;29395325;29440070;29501855;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30174290;30315122;30770398;30779550;30833945;31020640;31031002;31154438;31530632;31844290;31848261;32093270;32157095;32161166;32350084;32357974;32387766;32502341;32716602;32801355;32938616;32983136;33091337;33123756;33298915;33392160;33486469;33592498;33691108;33717175;33808629;33911136;33912179;33968037;33981976;34171305;34174402;34357683;34561969;34654017;34932366;34974812;35051231;35054769;35154160;35215835;35251023;35318648;35580925;35685460;35947956;36010968;36215666;36284347;36581221;36712380;37127961;37217939;37938771;38793607;40914422;7491766;7515177;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7545299;7565688;7588299;7590364;7683646;7689487;7693978;7737357;7903669;8576172;8576179;8661426;8666242;8692836;8781553;8810342;8817670;8894645;8910500;8964575;9034343;9037597;9079663;9442054;9447982;9450183;9473480;9497324;9521856;9528799;9687506;9709957;9733769;9737981;9786878;9819388;9920933;9922210",
        "class_list": "",
        "function": "Biallelic DNAJC3 variants in a neuroendocrine developmental disorder with insulin dysregulation., [RefSeq, PubMed]; DNAJC3 deficiency induces beta-cell mitochondrial apoptosis and causes syndromic young-onset diabetes., [RefSeq, PubMed]; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; P58(IPK) is an important component of a negative feedback loop used by the cell to inhibit eIF2alpha signaling, and thus attenuate the unfolded protein response., [RefSeq, PubMed]; Reduced DNAJC3 Expression Affects Protein Translocation across the ER Membrane and Attenuates the Down-Modulating Effect of the Translocation Inhibitor Cyclotriazadisulfonamide. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86WT9;Q8N4N2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051087 protein-folding chaperone binding;GO:0004860 protein kinase inhibitor activity;GO:0051787 misfolded protein binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005829 cytosol",
        "go_biological_process": "GO:0036494 positive regulation of translation initiation in response to endoplasmic reticulum stress;GO:0070417 cellular response to cold;GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation;GO:0043066 negative regulation of apoptotic process;GO:0051607 defense response to virus",
        "synthesized_glycan_count": 0,
        "hit_score": 30.2,
        "record_id": "Q13217-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14209-1",
        "uniprot_id": "E2F2_HUMAN",
        "mass": 47506.0,
        "length": 437,
        "protein_name": "Transcription factor E2F2",
        "gene_name": "E2F2",
        "organism": "Human",
        "refseq_name": "transcription factor E2F2",
        "refseq_ac": "NP_004082",
        "gene_names_uniprotkb": "E2F2",
        "gene_names_refseq": "E2F-2; E2F2",
        "protein_names_uniprotkb": "Transcription factor E2F2; E2F-2",
        "protein_names_refseq": "transcription factor E2F2",
        "tax_id": 9606,
        "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); prostate cancer (Disease Ontology:DOID:10283)",
        "pathway": " (hsa:1870);  (R-HSA-2559580);  (R-HSA-2559585);  (R-HSA-69231);  (R-HSA-9661069)",
        "pathway_count": 5,
        "publication_count": 167,
        "publication_id_list": "10207050;10347217;10358095;10385618;10499802;10722742;10772813;10831586;10871633;11032757;11073976;11157749;11231573;11234019;11416152;11564866;11719808;11782450;11883935;11884610;12134156;12189133;12193592;12421820;12435631;12435635;12444543;12502741;12808055;13130464;1423597;14507994;14517297;14532106;14597415;14729966;15287722;15469821;15563468;15572696;15579463;15716352;15866172;16186825;16195327;16211008;16337592;16360038;16436515;16782892;16826196;17092340;17210787;17254966;17254967;17254968;17255097;17332741;17344414;17395714;17765224;17825402;17875933;17908796;1826560;1828392;1828393;1828394;18365017;18414028;18669648;18710949;18793328;18827403;19075005;19451217;19451218;19458076;19462008;19487459;19528227;20107323;20534573;20663872;20843055;20952511;21423214;21715330;21986495;22020331;22325352;22336108;22683641;23007395;23622515;23737759;24515438;24876129;25733683;26992070;28228285;28832583;29242379;30315122;30711375;31092671;31543423;31844290;32157095;32488085;32502341;32938616;33298915;33592498;33717175;33912179;33981976;34171305;36291740;36375317;36766839;38152068;38253038;38360622;7535770;7588608;7588633;7797074;7816143;7859739;7954814;8001816;8078588;8114739;8139570;8246995;8246996;8259215;8319905;8336704;8413249;8497257;8552081;8622669;8622688;8626550;8741839;8774846;8846784;8974401;9030721;9042862;9106657;9144196;9162092;9190208;9195981;9325318;9342358;9447971;9448290;9508775;9529249;9564042;9628874;9768359;9824166",
        "class_list": "",
        "function": "Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy., [RefSeq, PubMed]; C/EBPbeta Coupled with E2F2 Promoted the Proliferation of hESC-Derived Hepatocytes through Direct Binding to the Promoter Regions of Cell-Cycle-Related Genes. Publication Status: Online-Only, [RefSeq, PubMed]; DNM3OS Enhances the Apoptosis and Senescence of Spermatogonia Associated with Nonobstructive Azoospermia by Providing miR-214-5p and Decreasing E2F2 Expression. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular Regulation of Heme Oxygenase-1 Expression by E2F Transcription Factor 2 in Lung Fibroblast Cells: Relevance to Idiopathic Pulmonary Fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; The association of E2F1 and E2F2 single nucleotide polymorphisms with laryngeal squamous cell carcinoma pathomorphological features. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R9W1;Q7Z6H1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:1903671 negative regulation of sprouting angiogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 17.0,
        "record_id": "Q14209-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q15768-1",
        "uniprot_id": "EFNB3_HUMAN",
        "mass": 35835.0,
        "length": 340,
        "protein_name": "Ephrin-B3",
        "gene_name": "EFNB3",
        "organism": "Human",
        "refseq_name": "ephrin-B3 precursor",
        "refseq_ac": "NP_001397",
        "gene_names_uniprotkb": "EFNB3; EPLG8; LERK8",
        "gene_names_refseq": "EFL6; EFNB3; EPLG8; LERK8",
        "protein_names_uniprotkb": "Ephrin-B3; EPH-related receptor transmembrane ligand ELK-L3; EPH-related receptor tyrosine kinase ligand 8; LERK-8",
        "protein_names_refseq": "EPH-related receptor transmembrane ligand ELK-L3; eph-related receptor tyrosine kinase ligand 8; ephrin-B3 precursor",
        "tax_id": 9606,
        "disease": "movement disease (Disease Ontology:DOID:480)",
        "pathway": " (hsa:1949);  (R-HSA-2682334);  (R-HSA-3928662);  (R-HSA-3928664);  (R-HSA-3928665)",
        "pathway_count": 5,
        "publication_count": 60,
        "publication_id_list": "10.1101/2023.09.13.557529;10047984;10197531;10219243;10848605;10995436;11058585;11134074;11448999;11557983;11580899;11747816;11780069;11804587;11983165;12084815;12495863;12546821;12676796;12695502;12702722;12973357;14988728;15340161;15351694;15378065;15548136;15721239;15800193;15848800;16298995;16477309;16511561;17310244;17322526;17376907;17428795;17440041;17548511;17928214;18713744;19525919;19553453;19915143;20496116;2201922;24275569;25505266;25892735;26479588;29557506;30262919;31011859;32387766;35051231;38142837;7478585;8808709;9126477;9499402",
        "class_list": "",
        "function": "(Microbial infection) Acts as a receptor for nipah virus and hendra virus., [UniProtKB, PubMed, PubMed]; Analysis of the association of EPHB6, EFNB1 and EFNB3 variants with hypertension risks in males with hypogonadism. Publication Status: Online-Only, [RefSeq, PubMed]; Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling., [RefSeq, PubMed]; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity)., [UniProtKB]; EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function.  The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]., [RefSeq]; Ephrin B3 exacerbates colitis and colitis-associated colorectal cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RBW2;D3DTQ6;O00680;Q8TBH7;Q92875",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046875 ephrin receptor binding;GO:0001618 virus receptor activity;GO:0005005 transmembrane-ephrin receptor activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:0098686 hippocampal mossy fiber to CA3 synapse",
        "go_biological_process": "GO:0007267 cell-cell signaling;GO:0007399 nervous system development;GO:0048013 ephrin receptor signaling pathway;GO:0007411 axon guidance;GO:0050771 negative regulation of axonogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "Q15768-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q16828-1",
        "uniprot_id": "DUS6_HUMAN",
        "mass": 42320.0,
        "length": 381,
        "protein_name": "Dual specificity protein phosphatase 6",
        "gene_name": "DUSP6",
        "organism": "Human",
        "refseq_name": "dual specificity protein phosphatase 6 isoform a",
        "refseq_ac": "NP_001937",
        "gene_names_uniprotkb": "DUSP6; MKP3; PYST1",
        "gene_names_refseq": "DUSP6; HH19; MKP3; PYST1",
        "protein_names_uniprotkb": "Dual specificity protein phosphatase 6; 3.1.3.16; 3.1.3.48; Dual specificity protein phosphatase PYST1; MAP kinase phosphatase 3; MKP-3; Mitogen-activated protein kinase phosphatase 3",
        "protein_names_refseq": "MAP kinase phosphatase 3; dual specificity protein phosphatase 6 isoform a; dual specificity protein phosphatase PYST1; mitogen-activated protein kinase phosphatase 3; serine/threonine specific protein phosphatase",
        "tax_id": 9606,
        "disease": "hypogonadotropic hypogonadism 19 with or without anosmia (Disease Ontology:DOID:0090090); developmental and epileptic encephalopathy 88 (Disease Ontology:DOID:0112222); breast cancer (Disease Ontology:DOID:1612); brain ischemia (Disease Ontology:DOID:2316); pancreatitis (Disease Ontology:DOID:4989)",
        "pathway": " (hsa:1848);  (R-HSA-112409);  (R-HSA-202670);  (R-HSA-5675221);  (R-HSA-9652817)",
        "pathway_count": 5,
        "publication_count": 82,
        "publication_id_list": "10048930;10206983;10415025;10490027;10702794;10757792;11237011;12583813;14724641;15632084;15664191;15851477;16892053;17097642;17208316;17322878;17724343;18294816;18332145;18452278;18515281;18547165;18669648;19091743;19106095;19158341;19413330;19664994;20230923;20332238;20463170;21779496;22569528;22730326;23105109;23643382;24390348;25314968;25597358;25631445;26992070;27600516;27760319;28832583;29043977;29242379;29331515;29375309;29393594;29557506;29769354;29789417;30429286;30524438;30779550;31154438;31844290;31848261;32157095;32387766;32488085;32721402;32897882;32983136;33392160;33537174;33592498;33968037;34185709;34686346;35051231;35318648;35580925;36284347;36462498;36806557;37029196;37938771;38678784;38821599;8670865;9858808",
        "class_list": "",
        "function": "DUSP6 is a memory retention feedback regulator of ERK signaling for cellular resilience of human pluripotent stem cells in response to dissociation. Publication Status: Online-Only, [RefSeq, PubMed]; Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases (PubMed:8670865). Has a specificity for the ERK family (PubMed:8670865). Plays an important role in alleviating chronic postoperative pain (By similarity). Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977)., [UniProtKB, UniProtKB, PubMed, PubMed]; Functional Role of DUSP6 in the EGFR-mediated Progression of Head and Neck Squamous Cell Carcinoma., [RefSeq, PubMed]; Long non-coding RNA NORAD regulates megakaryocyte differentiation and proplatelet formation via the DUSP6/ERK signaling pathway., [RefSeq, PubMed]; N6-methyadenosine modified SUV39H2 regulates homologous recombination through epigenetic repression of DUSP6 in gastric cancer., [RefSeq, PubMed]; SKA1 promotes tumor metastasis via SAFB-mediated transcription repression of DUSP6 in clear cell renal cell carcinoma., [RefSeq, PubMed]; The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75109;Q53Y75;Q9BSH6",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.21;3.1.3.18;3.1.3.-;3.1.3.5;3.1.3.2;2.7.11.24;2.7.10.1;3.1.3.67;3.1.3.53;2.7.11.22;3.1.3.52;3.1.3.27;3.1.3.86;3.1.3.36;3.1.3.74",
        "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0060420 regulation of heart growth;GO:0030154 cell differentiation;GO:0043065 positive regulation of apoptotic process;GO:0051409 response to nitrosative stress",
        "synthesized_glycan_count": 0,
        "hit_score": 8.3,
        "record_id": "Q16828-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5VZB9-1",
        "uniprot_id": "DMRTA_HUMAN",
        "mass": 53125.0,
        "length": 504,
        "protein_name": "Doublesex- and mab-3-related transcription factor A1",
        "gene_name": "DMRTA1",
        "organism": "Human",
        "refseq_name": "doublesex- and mab-3-related transcription factor A1",
        "refseq_ac": "NP_071443",
        "gene_names_uniprotkb": "DMRTA1; DMO",
        "gene_names_refseq": "DMO; DMRT4; DMRTA1",
        "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor A1",
        "protein_names_refseq": "doublesex- and mab-3-related transcription factor A1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:63951)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11863363;16959974;19664994;25865352;32387766;35051231;37744275",
        "class_list": "",
        "function": "A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis, XIRP2 and DMRTA1., [RefSeq, PubMed]; The DMRTA1-SOX2 positive feedback loop promotes progression and chemotherapy resistance of esophageal squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L481;Q8N8Y9;Q9H4B9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007548 sex differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q5VZB9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6PKH6-1",
        "uniprot_id": "DR4L2_HUMAN",
        "mass": 24863.0,
        "length": 232,
        "protein_name": "Dehydrogenase/reductase SDR family member 4-like 2",
        "gene_name": "DHRS4L2",
        "organism": "Human",
        "refseq_name": "dehydrogenase/reductase SDR family member 4-like 2 isoform 1 precursor",
        "refseq_ac": "NP_932349",
        "gene_names_uniprotkb": "DHRS4L2; SDR25C3",
        "gene_names_refseq": "DHRS4L2; SDR25C3",
        "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 4-like 2; 1.1.-.-; Protein SDR25C3; Short chain dehydrogenase/reductase family 25C member 3",
        "protein_names_refseq": "NADPH-dependent retinol dehydrogenase/reductase-like protein 2; dehydrogenase/reductase (SDR family) member 4 like 2A3; dehydrogenase/reductase SDR family member 4-like 2 isoform 1 precursor; short chain dehydrogenase/reductase family 25C member 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:317749)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11237011;16204458;19027726;23036705;28228285;28832583;29242379;32265295",
        "class_list": "",
        "function": "DHRS4L2 is a duplicate syntenic form of the human DHRS4 gene., [RefSeq, PubMed]; Probable oxidoreductase., [UniProtKB]; This gene encodes a member of the short chain dehydrogenase reductase family. The encoded protein may be an NADPH dependent retinol oxidoreductase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "H0YN69;Q3YLD4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004090 carbonyl reductase (NADPH) activity;GO:0016491 oxidoreductase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005739 mitochondrion;GO:0005777 peroxisome",
        "go_biological_process": "GO:0042574 retinal metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q6PKH6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6V1X1-1",
        "uniprot_id": "DPP8_HUMAN",
        "mass": 103358.0,
        "length": 898,
        "protein_name": "Dipeptidyl peptidase 8",
        "gene_name": "DPP8",
        "organism": "Human",
        "refseq_name": "dipeptidyl peptidase 8 isoform 3",
        "refseq_ac": "NP_001307804",
        "gene_names_uniprotkb": "DPP8; DPRP1; MSTP097; MSTP135; MSTP141",
        "gene_names_refseq": "DP8; DPP8; DPRP-1; DPRP1; MST097; MSTP097; MSTP135; MSTP141",
        "protein_names_uniprotkb": "Dipeptidyl peptidase 8; 3.4.14.5; DP8; DPP VIII; DPRP-1; Dipeptidyl peptidase IV-related protein 1; Dipeptidyl peptidase VIII; Prolyl dipeptidase DPP8",
        "protein_names_refseq": "DPP VIII; dipeptidyl peptidase 8 isoform 3; dipeptidyl peptidase IV-related protein 1; dipeptidyl peptidase VIII; prolyl dipeptidase DPP8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54878)",
        "pathway_count": 1,
        "publication_count": 79,
        "publication_id_list": "11012666;11237011;12534281;12662155;14729942;15039077;15664838;17924679;20112406;20536396;22544926;23481700;24366607;24714562;24715725;25418920;25505266;25576301;25645385;25880248;26375851;26811146;26992070;27820798;27862975;27920218;28063628;28228285;28832583;28834231;28855257;28904123;29242379;29382749;29393594;29493099;29557506;29632046;29786170;29967349;30315122;30429286;30524438;31092671;31530632;31844290;31848261;31937595;31998317;32157095;32265295;32357974;32387766;32488085;32502341;32796818;32897882;32938616;32983136;33141586;33298915;33592498;33731929;33731932;33912179;33932609;33936100;33968037;34019797;34171305;34357683;34509645;34561969;34932366;35051231;35580925;36010968;37938771;38458339",
        "class_list": "",
        "function": "DPP8/9 inhibition attenuates the TGF-beta1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways., [RefSeq, PubMed]; Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396, PubMed:29382749). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:32796818). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:33731929, PubMed:33731932, PubMed:34019797). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the proximal renal tubule epithelial cells., [RefSeq, PubMed]; This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7Z4C8;Q7Z4D3;Q7Z4E1;Q8IWG7;Q8NEM5;Q96JX1;Q9HBM2;Q9HBM3;Q9HBM4;Q9HBM5;Q9NXF4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0004177 aminopeptidase activity;GO:0008236 serine-type peptidase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006508 proteolysis;GO:0006955 immune response;GO:0006915 apoptotic process;GO:0043069 negative regulation of programmed cell death",
        "synthesized_glycan_count": 0,
        "hit_score": 8.0,
        "record_id": "Q6V1X1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZN92-1",
        "uniprot_id": "DUTL_HUMAN",
        "mass": 15492.0,
        "length": 141,
        "protein_name": "Putative inactive deoxyuridine 5'-triphosphate nucleotidohydrolase-like protein FLJ16323",
        "gene_name": "",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative inactive deoxyuridine 5'-triphosphate nucleotidohydrolase-like protein FLJ16323; dUTPase-like protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004170 dUTP diphosphatase activity",
        "go_cellular_component": "",
        "go_biological_process": "GO:0006226 dUMP biosynthetic process;GO:0046081 dUTP catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "Q6ZN92-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IZD9-1",
        "uniprot_id": "DOCK3_HUMAN",
        "mass": 233103.0,
        "length": 2030,
        "protein_name": "Dedicator of cytokinesis protein 3",
        "gene_name": "DOCK3",
        "organism": "Human",
        "refseq_name": "dedicator of cytokinesis protein 3",
        "refseq_ac": "NP_004938",
        "gene_names_uniprotkb": "DOCK3; KIAA0299; MOCA",
        "gene_names_refseq": "DOCK3; MOCA; NEDIDHA; PBP",
        "protein_names_uniprotkb": "Dedicator of cytokinesis protein 3; Modifier of cell adhesion; PBP; PS binding protein; Presenilin-binding protein",
        "protein_names_refseq": "PS binding protein; dedicator of cytokinesis protein 3; modifier of cell adhesion; presenilin-binding protein",
        "tax_id": 9606,
        "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); neurodevelopmental disorder with impaired intellectual development, hypotonia, and ataxia (MONDO:MONDO:0032661)",
        "pathway": " (hsa:1795);  (R-HSA-9013149);  (R-HSA-9013404);  (R-HSA-9013408);  (R-HSA-9032759);  (R-HSA-983231)",
        "pathway_count": 6,
        "publication_count": 313,
        "publication_id_list": "10.1101/2023.09.13.557529;10232922;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10652265;10699171;10699464;10847683;10854253;10873802;10958683;11007481;11042108;11058585;11062261;11085924;11145705;11149925;11242053;11373293;11396949;11431473;11432776;11584276;11672528;11689693;11696419;11704860;11707441;11744692;11751636;11756552;11773441;11803464;11804587;11804589;11804590;11864571;11884391;11895428;11912491;11919634;11950885;11961559;11967128;12032298;12071859;12093360;12096337;12134158;12177196;12195014;12221096;12351724;12376551;12427746;12432077;12531887;12546821;12547822;12650940;12665586;12857875;12877655;12923183;14512443;14514689;14569117;1464587;14675773;14718541;15020713;15023524;15033976;15064355;15107133;15133129;15147912;15169870;15247287;15302923;15339924;15342493;15485661;15507211;15542837;15579468;15601624;15611138;15710388;15728722;15814684;15850391;15858067;15897194;16002401;16054028;16081809;16112081;16116428;16184169;16243035;16243036;1630448;16339170;16473593;16492808;16507994;16519628;1660188;16636067;16702231;16762923;16777452;16777849;16862148;16896804;16914516;16968698;17027967;17060455;17077126;17145773;17158234;17196961;17214551;17244649;17269730;17583407;17599059;17698854;17702745;17765681;17804252;17976533;18006505;18045877;18056264;18191593;18218625;18249095;18347018;18396277;18426980;18653540;18662984;18838382;19269969;19293402;19494238;19581409;19605563;19651622;19673492;19713215;19934221;20368433;20400958;20460433;20530532;20627800;20679435;20810653;21148482;21151158;21378159;21542010;21565175;21613211;21621533;21730051;21865595;218813;21989057;22004470;22096251;22298643;22407364;22475431;22608513;22734669;22970203;23209303;23255595;23288169;23434736;23481700;23572525;23707487;23718289;23757206;23870057;23940355;24086303;24259668;24335996;24352656;24623723;24659802;24715725;24859002;24933155;24960694;25024229;25211221;25428919;25704760;25721503;25795300;25862245;25892735;26016997;26129894;26529257;26845023;26887924;27117132;27145964;27216196;27481945;27555588;27566826;27713499;27806292;28114311;28195318;28196833;28411811;28832583;29089502;29130632;29358323;29382922;29557506;29769354;30377343;30379171;30779550;30853411;30976111;31154438;31389670;31848261;31871319;32157095;32203420;32357974;32766788;32983136;33392160;33592498;33968037;3409321;34185709;35051231;35580925;36010968;37217939;37938771;7476457;7479768;7512369;7559638;7673236;7721814;7753201;7835339;8021274;8107774;8537347;8543060;8643598;8645157;8662638;8662891;8756646;8769096;8798539;8805223;8810315;8816443;8816476;8939998;8990121;8994827;9013646;9065479;9099726;9113980;9230307;9305890;9326583;9331217;9422515;9438849;9490638;9497316;9582072;9659915;9670022;9705280;9792683;9822598;9822605;9843499;9927674;9988689",
        "class_list": "",
        "function": "DOCK3 is a dosage-sensitive regulator of skeletal muscle and Duchenne muscular dystrophy-associated pathologies., [RefSeq, PubMed]; Hree patients with genetic variants in the dedicator of cytokinesis 3 (DOCK3) who presented with global developmental delay (GDD), hypotonia, and wide-based or uncoordinated gait., [RefSeq, PubMed]; Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity)., [UniProtKB]; This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 60,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O15017",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0017124 SH3 domain binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0048011 neurotrophin TRK receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 31.8,
        "record_id": "Q8IZD9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IZU8-1",
        "uniprot_id": "DSEL_HUMAN",
        "mass": 139238.0,
        "length": 1212,
        "protein_name": "Dermatan-sulfate epimerase-like protein",
        "gene_name": "DSEL",
        "organism": "Human",
        "refseq_name": "dermatan-sulfate epimerase-like protein precursor",
        "refseq_ac": "NP_115536",
        "gene_names_uniprotkb": "DSEL; C18orf4; NCAG1",
        "gene_names_refseq": "C18orf4; DE-epi2; DSEL",
        "protein_names_uniprotkb": "Dermatan-sulfate epimerase-like protein; 5.1.-.-",
        "protein_names_refseq": "NCAG1; dermatan-sulfate epimerase-like protein precursor; dermatan-sulfate epimerase-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:92126);  (R-HSA-2022923)",
        "pathway_count": 2,
        "publication_count": 28,
        "publication_id_list": "10187838;11414686;11470797;12512856;12556911;12874280;16505484;16959974;19188366;19661164;20358601;20533528;23704329;24714562;26375851;27846572;29393594;29557506;30429286;31844290;32938616;33392160;33592498;34105348;36010968;36241641;37217939;38253038",
        "class_list": "glycogene",
        "function": "DSEL was selected for study in 125 patients with diaphragmatic hernias, as it is involved in the synthesis of decorin, a protein that is required for normal collagen formation and that is upregulated during myogenesis., [RefSeq, PubMed]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1403,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q17RH1;Q6P5Z3",
        "ec_number_list": "5.1.-.-;5.1.3.19",
        "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0047757 chondroitin-glucuronate 5-epimerase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane",
        "go_biological_process": "GO:0050655 dermatan sulfate proteoglycan metabolic process;GO:0050651 dermatan sulfate proteoglycan biosynthetic process;GO:0050654 chondroitin sulfate proteoglycan metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q8IZU8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N7B9-1",
        "uniprot_id": "EFCB3_HUMAN",
        "mass": 50147.0,
        "length": 438,
        "protein_name": "EF-hand calcium-binding domain-containing protein 3",
        "gene_name": "EFCAB3",
        "organism": "Human",
        "refseq_name": "EF-hand calcium-binding domain-containing protein 3 isoform a",
        "refseq_ac": "NP_001138405",
        "gene_names_uniprotkb": "EFCAB3",
        "gene_names_refseq": "EFCAB3",
        "protein_names_uniprotkb": "EF-hand calcium-binding domain-containing protein 3",
        "protein_names_refseq": "EF-hand calcium-binding domain-containing protein 3 isoform a; EF-hand calcium-binding domain-containing protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:146779)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "11237011;16964243;29393594;31222486;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "J3KQM8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q8N7B9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TDB6-1",
        "uniprot_id": "DTX3L_HUMAN",
        "mass": 83554.0,
        "length": 740,
        "protein_name": "E3 ubiquitin-protein ligase DTX3L",
        "gene_name": "DTX3L",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase DTX3L",
        "refseq_ac": "NP_612144",
        "gene_names_uniprotkb": "DTX3L; BBAP",
        "gene_names_refseq": "BBAP; DTX3L; RNF143",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase DTX3L; 2.3.2.27; B-lymphoma- and BAL-associated protein; Protein deltex-3-like; RING-type E3 ubiquitin transferase DTX3L; Rhysin-2; Rhysin2",
        "protein_names_refseq": "B-lymphoma- and BAL-associated protein; E3 ubiquitin-protein ligase DTX3L; RING-type E3 ubiquitin transferase DTX3L; deltex 3 like, E3 ubiquitin ligase; deltex 3-like; rhysin-2; rhysin2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:151636);  (R-HSA-983168)",
        "pathway_count": 2,
        "publication_count": 136,
        "publication_id_list": "11062501;11350924;12646216;12670957;14734113;15224091;15224092;15571818;16595681;16809771;16849449;16954532;16959974;16964243;18452278;18618715;18662542;18669648;18691976;19028597;19352404;19369195;19452197;19489725;19818714;19851334;19874575;19940261;20058876;20068231;20112406;20166139;22411408;22424782;2261476;23186163;23230272;23481700;23783831;24275569;24366607;24714562;24715725;24790097;25418920;25469497;25576301;25880248;25892735;26154972;26375851;26479788;26728094;26811146;26929215;26992070;27600516;27846572;27862975;27893789;27920218;28218747;28228285;28467828;28514659;28525742;28832583;28834231;28904123;29242379;29331515;29351928;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30315122;30410026;30429286;30484775;30524438;30833945;31154438;31217245;31530632;31844290;31848261;31998317;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33717175;33912179;33936100;33968037;33981976;34087483;34105348;34171305;34290406;34357683;34509645;34725712;34932366;35051231;35154160;35318648;35580925;36241641;36284347;36581221;37460862;37774567;37938771;38000390;39242775;40914422;9380723;9668046",
        "class_list": "",
        "function": "BAL1 and BBAP are located on chromosome 3q21 in a head-to-head orientation and are regulated by a IFN-gamma-responsive bidirectional promoter., [RefSeq, PubMed]; DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on nucleic acids., [RefSeq, PubMed]; DTX3L Accelerates Pancreatic cancer Progression via FAK/PI3K/AKT Axis., [RefSeq, PubMed]; DTX3L mediated ubiquitination of cGAS suppresses antitumor immunity in pancreatic cancer., [RefSeq, PubMed]; Data directly implicate BBAP in the monoubiquitylation and additional posttranslational modification of histone H4 and an associated DNA damage response., [RefSeq, PubMed]; E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:23230272, PubMed:26479788). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteasomal-mediated degradation (PubMed:26479788)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; It is reported that BBAP and the human family of DTX proteins (DTX1, DTX2, and DTX3) function as E3 ligases based on their capacity for self-ubiquitination., [RefSeq, PubMed]; Overexpression of DTX3L, PIK3R4, ATP2C1, and SLC25A36, all located at 3q21.1-23 are associated with cervical cancer., [RefSeq, PubMed]; Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KWH6;Q53ZZ3;Q5MJP7",
        "ec_number_list": "2.3.2.24;2.3.2.23;2.3.2.26;2.3.2.27;2.3.2.31;2.3.2.-;6.2.1.-;2.3.2.34;2.3.2.32;3.6.4.-;2.3.2.25;2.3.2.36;2.7.11.1",
        "go_molecular_function": "GO:0097677 STAT family protein binding;GO:0004857 enzyme inhibitor activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0061630 ubiquitin protein ligase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005764 lysosome",
        "go_biological_process": "GO:0035563 positive regulation of chromatin binding;GO:1902966 positive regulation of protein localization to early endosome;GO:2000646 positive regulation of receptor catabolic process;GO:0007219 Notch signaling pathway;GO:0015031 protein transport",
        "synthesized_glycan_count": 0,
        "hit_score": 14.2,
        "record_id": "Q8TDB6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WWZ3-1",
        "uniprot_id": "EDAD_HUMAN",
        "mass": 24802.0,
        "length": 215,
        "protein_name": "Ectodysplasin-A receptor-associated adapter protein",
        "gene_name": "EDARADD",
        "organism": "Human",
        "refseq_name": "ectodysplasin-A receptor-associated adapter protein isoform B",
        "refseq_ac": "NP_542776",
        "gene_names_uniprotkb": "EDARADD",
        "gene_names_refseq": "CR; ECTD11A; ECTD11B; ED3; EDA3; EDARADD",
        "protein_names_uniprotkb": "Ectodysplasin-A receptor-associated adapter protein; EDAR-associated death domain protein; Protein crinkled homolog",
        "protein_names_refseq": "EDAR associated death domain; EDAR-associated death domain protein; crinkled homolog; ectodysplasia A receptor associated death domain; ectodysplasin-A receptor-associated adapter protein isoform B; ectodysplasin-A receptor-associated adapter protein",
        "tax_id": 9606,
        "disease": "ectodermal dysplasia 11A (Disease Ontology:DOID:0111653); ectodermal dysplasia 11B (Disease Ontology:DOID:0111654); otitis media (Disease Ontology:DOID:10754); hypohidrotic ectodermal dysplasia (Disease Ontology:DOID:14793)",
        "pathway": " (hsa:128178);  (R-HSA-5669034)",
        "pathway_count": 2,
        "publication_count": 46,
        "publication_id_list": "10074428;10359578;10398604;10484778;10597252;10615125;11237011;11571266;11780064;11882293;11911831;12189164;12949498;14656435;15356117;15470070;16501042;1655907;17354266;17632511;18231121;18571443;18606301;20032458;20222921;20307208;20510730;20979233;21300286;22197273;22664871;22801960;24070496;29242379;29493099;29632046;32488085;34219261;34573371;35637063;37673591;37838280;7913952;8120384;8871664;9878548",
        "class_list": "",
        "function": "A new variant of the ectodysplasin A receptor death domain gene associated with anhidrotic ectodermal dysplasia in a Turkish family and its simple diagnosis by restriction fragment length polymorphism., [RefSeq, PubMed]; Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Characterization of EDARADD gene mutations responsible for hypohidrotic ectodermal dysplasia., [RefSeq, PubMed]; Crinkled binds EDAR through a homotypic death domain interaction and mediates engagement of the NF-kappaB pathway, possibly by recruiting TRAF2 to the receptor-signaling complex, [RefSeq, PubMed]; EDARADD promotes colon cancer progression by suppressing E3 ligase Trim21-mediated ubiquitination and degradation of Snail., [RefSeq, PubMed]; EDARADD silencing suppresses the proliferation and migration of bladder cancer cells., [RefSeq, PubMed]; Gene Mutations of the Three Ectodysplasin Pathway Key Players (EDA, EDAR, and EDARADD) Account for More than 60% of Egyptian Ectodermal Dysplasia: A Report of Seven Novel Mutations. Publication Status: Online-Only, [RefSeq, PubMed]; Interacts with the death domain of Edar and links the receptor to downstream signalling pathways, [RefSeq, PubMed]; This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2VCK5;A8K7B5;B1AL54;B9ZVW5;Q5VYJ7",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0007165 signal transduction;GO:0030154 cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "Q8WWZ3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96AV8-1",
        "uniprot_id": "E2F7_HUMAN",
        "mass": 99888.0,
        "length": 911,
        "protein_name": "Transcription factor E2F7",
        "gene_name": "E2F7",
        "organism": "Human",
        "refseq_name": "transcription factor E2F7",
        "refseq_ac": "NP_976328",
        "gene_names_uniprotkb": "E2F7",
        "gene_names_refseq": "E2F7",
        "protein_names_uniprotkb": "Transcription factor E2F7; E2F-7",
        "protein_names_refseq": "E2F-7; transcription factor E2F7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:144455);  (R-HSA-6804116)",
        "pathway_count": 2,
        "publication_count": 68,
        "publication_id_list": "10891498;11237011;11812999;12692263;14580351;14633988;15133492;15722552;15897886;17200349;17719541;18194653;18202719;18669648;19223542;19651622;20068231;20817677;21248772;22172947;22802528;22802529;22903062;23064264;23186163;24366607;24715725;25576301;26154972;26375851;27452520;27600516;27920218;28832583;28834231;29242379;30620550;31217245;31530632;31839203;31844290;32157095;32161166;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33592498;33717175;33968037;34087483;34171305;34561969;35051231;35580925;36010968;36215666;36241641;37615745;38073330;38241554;38454344;39192374;8242752;9780002",
        "class_list": "",
        "function": "Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; CISD2 transcriptional activated by transcription factor E2F7 promotes the malignant progression of cervical cancer., [RefSeq, PubMed]; Down-regulation of E2F7 may contribute to mechanisms underlying platinum resistance in ovarian neoplasms, [RefSeq, PubMed]; E2F7 serves as a potential prognostic biomarker for lung adenocarcinoma., [RefSeq, PubMed]; P53/E2F7 axis promotes temozolomide chemoresistance in glioblastoma multiforme. Publication Status: Online-Only, [RefSeq, PubMed]; Plays an essential role in the regulation of cell cycle progression., [RefSeq, PubMed]; The novel circFKBP8/miR-432-5p/E2F7 cascade functions as a regulatory network in breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The similarities between E2F-7 and E2F-8 define a new subgroup of the E2F family, and further imply that E2F-7 and E2F-8 may act through overlapping mechanisms in mediating cell cycle control., [RefSeq, PubMed]; Transcription Factor E2F7 Hampers the Killing Effect of NK Cells against Colorectal Cancer Cells via Activating RAD18 Transcription., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NC74;B2RMR7;B3KTZ5;B3KUP8;B5MED9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex;GO:0005634 nucleus;GO:0005667 transcription regulator complex",
        "go_biological_process": "GO:0032877 positive regulation of DNA endoreduplication;GO:0060718 chorionic trophoblast cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 7.1,
        "record_id": "Q96AV8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y6I3-2",
        "uniprot_id": "EPN1_HUMAN",
        "mass": 60293.0,
        "length": 576,
        "protein_name": "Epsin-1",
        "gene_name": "EPN1",
        "organism": "Human",
        "refseq_name": "epsin-1 isoform a",
        "refseq_ac": "NP_001123543",
        "gene_names_uniprotkb": "EPN1",
        "gene_names_refseq": "EPN1",
        "protein_names_uniprotkb": "Epsin-1; EH domain-binding mitotic phosphoprotein; EPS-15-interacting protein 1",
        "protein_names_refseq": "EH domain-binding mitotic phosphoprotein; EPS-15-interacting protein 1; epsin-1 isoform a",
        "tax_id": 9606,
        "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)",
        "pathway": " (hsa:29924);  (R-HSA-182971);  (R-HSA-8856825);  (R-HSA-8856828)",
        "pathway_count": 4,
        "publication_count": 286,
        "publication_id_list": "10097102;10393179;10436022;10514377;10535736;10542231;10557078;10559856;10559861;10559924;10567358;10613896;10625686;10652316;10764745;10766823;10769163;10953014;10983987;11071885;11076969;11082044;11231140;11239472;11247302;11454741;11470803;11516654;11517213;11532990;11577110;11588219;11823423;11877457;11877461;11889126;11894095;11919637;11927540;11988742;12057195;12072436;12086608;12213833;12218189;12221107;12234920;12234931;12429842;12447393;12451172;12464600;12593795;12593796;12717448;12775724;12836669;12847086;12944396;12952949;12958364;1317852;14505571;14555962;14581451;14617351;14622578;14622579;14662753;14726597;14985334;15021893;15117950;15134832;15252009;15260957;15318165;15339664;1535555;15465819;15473838;15475003;15502812;15502813;15649145;15671180;15701692;15703209;15728179;15802264;15895077;15916959;15962011;16103228;16159959;16215232;16326391;16407834;16410077;16459302;16460808;16516836;16707488;16723738;16798879;16880396;16903783;16964243;17018281;17035995;17081983;17158794;17267500;17360967;17456551;17494869;17512409;17522231;17540576;17609109;17681954;17713526;17762867;17765681;17978091;18032517;18093523;18166656;18199683;18388313;1847920;18669648;18775314;18790740;18819912;18981233;19054389;19092055;19140243;19287005;19296720;19367720;19458185;19536138;19575674;19603039;1968060;19690332;19696796;19696798;19713939;19732400;19776351;19809571;19814798;19853559;20033059;20059951;20068231;20211604;20231386;20351096;20428113;20448150;20826345;20946875;21102408;2115402;21187331;21278753;21316588;21376233;21445324;21482805;21499258;21613550;21779028;21841790;21883765;21927000;21927001;21962517;21995445;22099461;22118466;22233676;22357968;22484487;22505844;2257624;22815487;22863004;22942912;23186163;23297414;23536704;23823722;23861397;23891661;24130457;24186068;24275569;24384571;24581490;24680432;24714562;24715725;24746795;24789820;24966051;25107275;25263444;25303366;25341920;26042225;26154972;26403691;26829388;27846572;27869121;27920218;28657654;2890644;29242379;29393594;29557506;30429286;30459171;30524438;30779550;30833945;31154438;31222486;31373491;31844290;31848261;32157095;32387766;32488085;32502341;32897882;32938616;32997199;33968037;33981976;34019948;34087483;34171305;3417785;34357683;34509645;34561969;34927784;35051231;35254053;35318648;35561310;35580925;36010968;36240223;36241641;36284347;37938771;38665916;6146630;7541030;7542744;7569928;7657591;7822302;7877694;8524399;8552632;8553074;8621719;8837779;9092476;9100026;9169477;9303539;9427626;9428629;9635431;9723620;9736607;9812899",
        "class_list": "",
        "function": "Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078)., [UniProtKB, PubMed, UniProtKB, PubMed]; Cooperativity of membrane-protein and protein-protein interactions control membrane remodeling by epsin 1 and affects clathrin-mediated endocytosis., [RefSeq, PubMed]; This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 6,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86ST3;Q9HA18",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005543 phospholipid binding;GO:0030276 clathrin binding;GO:0140313 molecular sequestering activity",
        "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005634 nucleus;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006897 endocytosis;GO:1903671 negative regulation of sprouting angiogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 29.3,
        "record_id": "Q9Y6I3-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P01275-1",
        "uniprot_id": "GLUC_HUMAN",
        "mass": 20909.0,
        "length": 180,
        "protein_name": "Pro-glucagon",
        "gene_name": "GCG",
        "organism": "Human",
        "refseq_name": "pro-glucagon preproprotein",
        "refseq_ac": "NP_002045",
        "gene_names_uniprotkb": "GCG",
        "gene_names_refseq": "GCG; GLP-1; GLP1; GLP2; GRPP",
        "protein_names_uniprotkb": "Pro-glucagon; Incretin hormone",
        "protein_names_refseq": "glicentin-related polypeptide; glucagon-like peptide 1; glucagon-like peptide 2; incretin; preproglucagon; pro-glucagon preproprotein; pro-glucagon",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); prediabetes syndrome (Disease Ontology:DOID:11716)",
        "pathway": " (hsa:2641);  (R-HSA-163359);  (R-HSA-381676);  (R-HSA-381771);  (R-HSA-416476);  (R-HSA-418555);  (R-HSA-420092);  (R-HSA-422085)",
        "pathway_count": 8,
        "publication_count": 190,
        "publication_id_list": "10191087;10318832;10322410;10567430;10604470;10605628;10698200;10727532;10861009;11007482;11015615;11060443;11071853;11089560;11564718;11600536;11742120;11753430;11756331;11943215;11946536;11978683;12034449;12036966;12050285;12058044;12106601;12120503;12180353;12180908;12354137;12401793;12410638;12414809;12475787;12496249;12540594;12553549;12554744;12626323;12627948;12651102;12810581;12860470;12938160;1333056;13549488;13680124;14557443;14599721;14632334;14671004;14719035;14719797;14988243;1499644;15126524;15126574;15142980;1517224;15256494;15464082;15471943;15569269;15584901;15604212;15619630;15765929;15769620;15951850;15955806;15995848;16182515;16219666;16268778;16313925;16339447;16613879;16687412;16728727;16754659;16923326;16973695;17065399;17095603;17168849;17289852;17306374;1739432;17444618;17595255;17681422;17900700;18044684;18202100;18287102;18396350;18412318;18434541;18443287;18515384;18519800;18577758;18936096;19001044;1905813;19105585;19280057;19327128;19628676;19859570;19861722;19876791;19929708;20381629;21036126;2163110;22037645;23863937;2417744;24687066;2491850;2553411;2553705;26308095;26417854;2753890;2826231;2841328;2871555;2901414;29443750;29557506;29602314;29789417;30828317;30833991;3086311;3127824;31279028;31399091;31983287;32193322;32226383;32497535;32540603;32618402;32715661;33049737;36284347;3725587;3841689;3899557;3900195;40446798;6085243;6192430;6745415;6877358;7589426;7589461;7680413;7700244;7811244;7883856;7902709;7937899;8100523;8138058;8144028;8340388;8390245;8404634;8405712;8482423;8514797;8664309;8672451;8798518;8830891;9263355;9287128;9305846;9417641;9488697;9651336;9667960;9770463;9920805;9990065",
        "class_list": "",
        "function": "May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life., [UniProtKB, PubMed, PubMed]; Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Binds to and activates the glucagon receptor GCGR, which couples to the G(s) G protein and elevates intracellular cAMP, triggering downstream metabolic responses (PubMed:32193322)., [UniProtKB, PubMed, PubMed, PubMed]; Potent stimulator of glucose-dependent insulin release (PubMed:22037645, PubMed:40446798). Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels (PubMed:10605628, PubMed:14719035, PubMed:12554744). May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin (PubMed:10605628, PubMed:14719035, PubMed:12554744). Has growth-promoting activities on intestinal epithelium (PubMed:10605628, PubMed:14719035, PubMed:12554744). May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion (PubMed:10605628, PubMed:14719035, PubMed:12554744). Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation (PubMed:10605628, PubMed:14719035, PubMed:12554744). Inhibits beta cell apoptosis (PubMed:10605628, PubMed:14719035, PubMed:12554744)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness., [UniProtKB, PubMed, PubMed]; Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene is a proglucagon precursor that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis in the liver. In addition, glucagon promotes lipolysis and ketone body formation during prolonged fasting or stress. Glucagon secretion is stimulated by low blood glucose and inhibited by high glucose or insulin. Glucagon is a ligand for a specific G-protein linked receptor called glucagon receptor, which activates the Gs protein-adenylate cyclase-cAMP-protein kinase A signaling pathway to regulate carbohydrate and lipid metabolism. Two of the other peptides, glucagon-like peptide-1 and glucagon-like peptide-2, are produced by the intestinal L-cells and secreted in response to nutrient ingestion, where they function as important regulators of glucose metabolism and intestinal physiology. Glucagon-like peptide-1 enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety, making it a key incretin hormone for maintaining postprandial glucose levels. Glucagon-like peptide-2 primarily acts on the gut, promoting intestinal growth, enhancing nutrient absorption, and supporting mucosal integrity. Both peptides exert their effects through specific G-protein-coupled receptors, glucagon-like peptide-1 receptor and glucagon-like peptide-2 receptor, respectively, and analogs of glucagon-like peptide-1 are used clinically for the treatment of type 2 diabetes and obesity. The fourth peptide is similar to glicentin, an active enteroglucagon produced in the intestinal L-cells. This peptide is thought to have multiple roles in gastrointestinal physiology, including stimulating intestinal growth, modulating gut motility, and influencing the secretion of other gut hormones. Although its precise functions are less well-characterized than those of glucagon, glucagon-like peptide-1, or glucagon-like peptide-2, glicentin-like peptides may contribute to postprandial digestive processes and the coordination of nutrient absorption. [provided by RefSeq, Mar 2026]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NN65;Q53TP6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031769 glucagon receptor binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0005179 hormone activity;GO:0048018 receptor ligand activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0005886 plasma membrane;GO:0034774 secretory granule lumen",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0032024 positive regulation of insulin secretion;GO:0043066 negative regulation of apoptotic process;GO:0070374 positive regulation of ERK1 and ERK2 cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 19.1,
        "record_id": "P01275-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6P1K8-1",
        "uniprot_id": "T2H2L_HUMAN",
        "mass": 44452.0,
        "length": 395,
        "protein_name": "General transcription factor IIH subunit 2-like protein",
        "gene_name": "GTF2H2C_2; GTF2H2C",
        "organism": "Human",
        "refseq_name": "general transcription factor IIH subunit 2-like protein isoform 1",
        "refseq_ac": "NP_001035955",
        "gene_names_uniprotkb": "GTF2H2C_2; GTF2H2C; GTF2H2D",
        "gene_names_refseq": "GTF2H2C_2; GTF2H2D",
        "protein_names_uniprotkb": "General transcription factor IIH subunit 2-like protein; General transcription factor IIH polypeptide 2-like protein",
        "protein_names_refseq": "general transcription factor IIH polypeptide 2-like protein; general transcription factor IIH subunit 2-like protein isoform 1; general transcription factor IIH subunit 2-like protein; general transcription factor IIH, polypeptide 2D",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:728340);  (hsa:730394)",
        "pathway_count": 2,
        "publication_count": 28,
        "publication_id_list": "18991276;22645359;24714562;26154972;26992070;28904123;29437277;29557506;30379171;30410026;31844290;32157095;32502341;32938616;32983136;33141586;33298915;33392160;33691108;33968037;33981976;34211107;34357683;34932366;35051231;35318648;35580925;36241641",
        "class_list": "",
        "function": "Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II., [UniProtKB]; VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC138827.3., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NED9;A8K8J6;B2RCU4;B7ZW39",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0016607 nuclear speck;GO:0005675 transcription factor TFIIH holo complex;GO:0000439 transcription factor TFIIH core complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006289 nucleotide-excision repair",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "Q6P1K8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P42658-1",
        "uniprot_id": "DPP6_HUMAN",
        "mass": 97588.0,
        "length": 865,
        "protein_name": "A-type potassium channel modulatory protein DPP6",
        "gene_name": "DPP6",
        "organism": "Human",
        "refseq_name": "A-type potassium channel modulatory protein DPP6 isoform 1",
        "refseq_ac": "NP_570629",
        "gene_names_uniprotkb": "DPP6",
        "gene_names_refseq": "DPL1; DPP6; DPPX; MRD33; VF2",
        "protein_names_uniprotkb": "A-type potassium channel modulatory protein DPP6; DPP VI; DPPX; Dipeptidyl aminopeptidase-like protein 6; Dipeptidyl aminopeptidase-related protein; Dipeptidyl peptidase 6; Dipeptidyl peptidase IV-like protein; Dipeptidyl peptidase VI",
        "protein_names_refseq": "A-type potassium channel modulatory protein DPP6 isoform 1; A-type potassium channel modulatory protein DPP6; DPP VI; dipeptidyl aminopeptidase IV-related protein; dipeptidyl aminopeptidase-like protein 6; dipeptidyl peptidase IV-related protein; dipeptidyl peptidase VI; dipeptidyl-peptidase 6",
        "tax_id": 9606,
        "disease": "autosomal dominant intellectual developmental disorder 33 (Disease Ontology:DOID:0070063); familial partial lipodystrophy type 6 (Disease Ontology:DOID:0070206); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); spinal muscular atrophy (Disease Ontology:DOID:12377); arteriosclerosis (Disease Ontology:DOID:2349); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); ventricular fibrillation, paroxysmal familial, 2 (MONDO:MONDO:0013063)",
        "pathway": " (hsa:1804)",
        "pathway_count": 1,
        "publication_count": 22,
        "publication_id_list": "11237011;15454437;15476821;1729689;18084291;18174402;18364354;19285295;19441798;23832105;29351928;29557506;30874922;31154438;31476289;31844290;32701143;33143549;35051231;37074911;38381392;8103397",
        "class_list": "",
        "function": "Analysis of the differential expression of two distinct forms of mRNA for the cow and rat orthologs. Names the variants S and L., [RefSeq, PubMed]; Association between DPP6 gene rs10260404 polymorphism and increased risk of sporadic amyotrophic lateral sclerosis (sALS): a meta-analysis., [RefSeq, PubMed]; Dipeptidyl peptidase like 6 promoter methylation is a potential prognostic biomarker for pancreatic ductal adenocarcinoma., [RefSeq, PubMed]; In an unresolved autosomal dominant dementia family significantly linked to 7q36, there was a chromosomal inversion of ca. 4 Mb, segregating on the disease haplotype and disrupting the coding sequence of DPP6. The missense variants found in patients destabilize DPP6 and reduce its membrane expression. DPP6 loss plays a in dementia., [RefSeq, PubMed]; Neuronal Differentiation of Induced Pluripotent Stem Cells from Schizophrenia Patients in Two-Dimensional and in Three-Dimensional Cultures Reveals Increased Expression of the Kv4.2 Subunit DPP6 That Contributes to Decreased Neuronal Activity., [RefSeq, PubMed]; Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:15476821, PubMed:8103397)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The slope of the activation curve of DPP6-L747P was slightly decreased., [RefSeq, PubMed]; This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 63,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 10,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0008236 serine-type peptidase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex",
        "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0006508 proteolysis;GO:0072659 protein localization to plasma membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "P42658-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96T88-1",
        "uniprot_id": "UHRF1_HUMAN",
        "mass": 89814.0,
        "length": 793,
        "protein_name": "E3 ubiquitin-protein ligase UHRF1",
        "gene_name": "UHRF1",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase UHRF1 isoform 1",
        "refseq_ac": "NP_001041666",
        "gene_names_uniprotkb": "UHRF1; ICBP90; NP95; RNF106",
        "gene_names_refseq": "ICBP90; Np95; RNF106; TDRD22; UHRF1; hNP95; hUHRF1; huNp95",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase UHRF1; 2.3.2.27; HuNp95; Inverted CCAAT box-binding protein of 90 kDa; Nuclear protein 95; Nuclear zinc finger protein Np95; RING finger protein 106; Transcription factor ICBP90; Ubiquitin-like PHD and RING finger domain-containing protein 1; hNp95; hUHRF1",
        "protein_names_refseq": "E3 ubiquitin-protein ligase UHRF1 isoform 1; E3 ubiquitin-protein ligase UHRF1; RING finger protein 106; RING-type E3 ubiquitin transferase UHRF1; inverted CCAAT box binding protein 90; inverted CCAAT box-binding protein of 90 kDa; nuclear phosphoprotein 95; nuclear protein 95; nuclear zinc finger protein Np95; transcription factor ICBP90; ubiquitin-like PHD and RING finger domain-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:29128);  (R-HSA-5334118);  (R-HSA-9821002)",
        "pathway_count": 3,
        "publication_count": 192,
        "publication_id_list": "10551868;10646863;11237011;12481029;12838312;15009091;15105426;15178447;15361834;15861382;16829525;16964243;17067204;17081983;17320160;17320161;17320163;17363312;17673620;17687327;17713478;17851529;17967883;18003914;18220336;18302924;18446792;18452278;18669648;18767875;18772889;18931436;18945682;19056828;19491893;19608861;19651622;19690332;19834512;20026581;20068231;20112406;20630873;20838592;20841325;21163962;21378119;21406692;21489993;21706000;21731699;21745816;21777816;21808299;21808300;21979949;22064703;22072796;22096602;22100450;22286757;22330138;22348533;22411829;22420752;22424782;22544926;22645359;22837395;22945642;23022729;23161542;23186163;23297342;23301498;23481700;23752590;23783831;24013172;24134914;24366607;24368767;24714562;24715725;25218447;25418920;25576301;25645385;25802875;25810538;25880248;25892735;26024233;26154972;26375851;26768311;26811146;26929215;26992070;27045799;27543614;27595565;27600516;27862975;27920218;28063628;28218747;28228285;28510447;28832583;28834231;28855257;28860189;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30104358;30315122;30335751;30357346;30392929;30392931;30410026;30484775;30524438;30779550;31154438;31217245;31222486;31530632;31575892;31844290;31848261;31937595;31998317;32051553;32157095;32161166;32357974;32387766;32428527;32488085;32502341;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33592498;33633747;33691108;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34405274;34509645;34561969;34932366;35051231;35083852;35314832;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37728657;37938771;38665916;38868925;38898124;39362877;39607687;39631394",
        "class_list": "",
        "function": "Aberrant cytoplasmic expression of UHRF1 restrains the MHC-I-mediated anti-tumor immune response. Publication Status: Online-Only, [RefSeq, PubMed]; E3 ubiquitin-protein ligase that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification (PubMed:10646863, PubMed:15009091, PubMed:19056828, PubMed:23022729, PubMed:24013172, PubMed:27595565, PubMed:30104358, PubMed:30392929, PubMed:30392931, PubMed:39607687). Plays a key role in DNA methylation inheritance by promoting recruitment of DNMT1 to hemimethylated DNA and ensure faithful propagation of the DNA methylation patterns through DNA replication (PubMed:23022729, PubMed:24013172, PubMed:27595565, PubMed:30104358, PubMed:30392929, PubMed:30392931, PubMed:39607687). Acts both as a histone reader and writer: specifically recognizes and binds (1) hemimethylated DNA at replication forks and (2) histone H3 trimethylated at 'Lys-9' and unmethylated at 'Arg-2' (H3K9me3 and H3R2me0, respectively), thereby activating its E3 ubiquitin-protein ligase activity (PubMed:15361834, PubMed:17673620, PubMed:17967883, PubMed:18772889, PubMed:21745816, PubMed:21777816, PubMed:22100450, PubMed:22837395, PubMed:23022729, PubMed:27595565, PubMed:30104358). UHRF1 then mediates histone H3 'Lys-18' monoubiquitination (H3K18ub), a docking site for DNMT1, leading to DNMT1 recruitment and replication-coupled DNA methylation maintenance (PubMed:27595565). Also mediates histone H3 'Lys-14' and 'Lys-23' ubiquitination (H3K14ub and H3K23ub) at lower level (PubMed:24013172, PubMed:27595565). Histone ubiquitin ligase activity also stimulates the methyltransferase activity of SUV39H1 and/or SUV39H2, promoting accumulation of H3K9me3 histone mark to reinformce heterochromatin state (PubMed:39631394). Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications (PubMed:21777816). Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation (PubMed:30335751). Also ubiquitinates non-histone proteins, such as histone H3, KIF11 and PML (PubMed:22945642, PubMed:37728657). Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; ICBP90 expression altered in cancer cell lines and upregulated by E2F-1 overexpression, with efficiency depending on cancer status of cell line, [RefSeq, PubMed]; Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Reviews the principles how UHRF1 acts as an epigenetic reader and discusses the properties of UHRF1 to be a biomarker as well as a therapeutic target Review article, [RefSeq, PubMed]; Structure of human DPPA3 bound to the UHRF1 PHD finger reveals its functional and structural differences from mouse DPPA3. Publication Status: Online-Only, [RefSeq, PubMed]; The maternal protein NLRP5 stabilizes UHRF1 in the cytoplasm: implication for the pathogenesis of multilocus imprinting disturbance., [RefSeq, PubMed]; These findings collectively indicate that the human NP95 gene is the functional orthologue of the murine Np95 gene., [RefSeq, PubMed]; This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 21,
        "reported_mutagensis": 42,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0JBR2;A8K024;B2RBA9;Q2HIX7;Q8J022;Q9H6S6;Q9P115;Q9P1U7",
        "ec_number_list": "2.1.1.37;2.3.2.27",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003676 nucleic acid binding;GO:0061630 ubiquitin protein ligase activity;GO:0000987 cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005819 spindle;GO:0016363 nuclear matrix;GO:0000785 chromatin",
        "go_biological_process": "GO:0050678 regulation of epithelial cell proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051247 positive regulation of protein metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 19.5,
        "record_id": "Q96T88-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P49810-1",
        "uniprot_id": "PSN2_HUMAN",
        "mass": 50140.0,
        "length": 448,
        "protein_name": "Presenilin-2",
        "gene_name": "PSEN2",
        "organism": "Human",
        "refseq_name": "presenilin-2 isoform 1",
        "refseq_ac": "NP_000438",
        "gene_names_uniprotkb": "PSEN2; AD4; PS2; PSNL2; STM2",
        "gene_names_refseq": "AD3L; AD4; CMD1V; PS2; PSEN2; STM2",
        "protein_names_uniprotkb": "Presenilin-2; 3.4.23.-; AD3LP; AD5; E5-1; PS-2; STM-2",
        "protein_names_refseq": "AD3LP; AD5; Alzheimer disease 3-like; Alzheimer disease 4; E5-1; PS-2; STM-2; presenilin-2 isoform 1",
        "tax_id": 9606,
        "disease": "early-onset Parkinson's disease (Disease Ontology:DOID:0060894); Alzheimer's disease 4 (Disease Ontology:DOID:0110040); Alzheimer's disease 3 (Disease Ontology:DOID:0110042); dilated cardiomyopathy 1V (Disease Ontology:DOID:0110427); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); dilated cardiomyopathy (Disease Ontology:DOID:12930); breast cancer (Disease Ontology:DOID:1612)",
        "pathway": " (hsa:5664);  (R-HSA-1251985);  (R-HSA-193692);  (R-HSA-205043);  (R-HSA-2122948);  (R-HSA-2644606);  (R-HSA-2894862);  (R-HSA-2979096);  (R-HSA-3928665);  (R-HSA-9013507);  (R-HSA-9013700);  (R-HSA-9017802);  (R-HSA-9839383)",
        "pathway_count": 13,
        "publication_count": 196,
        "publication_id_list": "10079256;10206645;10497236;10551863;10631141;10652302;10713164;10732806;10854253;10879540;10882063;10934472;10958687;10964718;11006133;11044625;11171333;11226752;11237011;11448999;11518718;11679632;11740940;11799129;11823422;11861489;12050117;12209127;12214059;12354787;12391150;12530964;12807903;12843241;12913006;12973357;14567914;14681895;14960584;14980219;15023535;15107403;15274632;15351694;15533827;15534001;15546612;15569487;15574878;15652348;15701642;15760269;15824097;15829515;15848800;15965470;16061658;16093323;16252010;16284625;16474849;16511561;16530044;16630834;16738328;16752394;16773578;16912174;16959576;17003037;17018285;17028573;17114293;17186461;17401372;17428795;17646408;17646409;18043734;18077452;18237417;18296446;18374649;1840698;18418349;18469519;18578522;18628966;18653779;18669648;18700817;18713744;18767875;18824583;18824585;19000840;19047365;19151708;19208840;19413330;19415658;19524514;19567869;19596786;19640841;19651622;19726682;20068231;20156974;20496116;20972443;21285369;21544564;21632553;22162134;22503161;22658935;22658936;23186163;23230144;24308844;24715725;24829397;24838186;24842903;24844686;25125655;25356737;25645385;25740432;25880248;26992070;27293189;27600516;28218747;28467828;28832583;28834231;29242379;29557506;29856954;29856955;30429286;3153318;31844290;32157095;32350084;32357974;32488085;32938616;32983136;33592498;33912179;33936100;33968037;33981976;34171305;34357683;35051231;35154160;35318648;35580925;36241641;36272978;37864790;37938771;38156414;38227890;38946496;7566092;7588063;7638622;7651536;803282;8313469;8574969;8618867;8661049;8972483;9207787;9207788;9244301;9315665;9384573;9384602;9437013;9462510;9521418;9558331;9590294;9604939;9620803;9651681;9694793;9819428;9990034",
        "class_list": "",
        "function": "Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]., [RefSeq]; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular amyloid beta that contains longer amyloid beta. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development., [RefSeq, PubMed]; Presenilin Gene Mutation-associated Psychosis: Phenotypic Characteristics and Clinical Implications. Review article, [RefSeq, PubMed]; Presenilin deficiency enhances tau phosphorylation and its secretion., [RefSeq, PubMed]; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Quantitative comparison of presenilin protein expression reveals greater activity of PS2-gamma-secretase., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 19,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 8,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K8D4;B1AP21;Q96P32",
        "ec_number_list": "2.7.10.1;3.4.23.-;2.3.2.27",
        "go_molecular_function": "GO:0042500 aspartic endopeptidase activity, intramembrane cleaving",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005813 centrosome",
        "go_biological_process": "GO:0035333 Notch receptor processing, ligand-dependent;GO:0006509 membrane protein ectodomain proteolysis;GO:0007219 Notch signaling pathway;GO:0007220 Notch receptor processing;GO:0016485 protein processing",
        "synthesized_glycan_count": 0,
        "hit_score": 19.7,
        "record_id": "P49810-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q08554-1",
        "uniprot_id": "DSC1_HUMAN",
        "mass": 99987.0,
        "length": 894,
        "protein_name": "Desmocollin-1",
        "gene_name": "DSC1",
        "organism": "Human",
        "refseq_name": "desmocollin-1 isoform Dsc1b precursor",
        "refseq_ac": "NP_004939",
        "gene_names_uniprotkb": "DSC1; CDHF1",
        "gene_names_refseq": "CDHF1; DG2/DG3; DSC1",
        "protein_names_uniprotkb": "Desmocollin-1; Cadherin family member 1; DG2/DG3; Desmosomal glycoprotein 2/3",
        "protein_names_refseq": "cadherin family member 1; desmocollin-1 isoform Dsc1b precursor; desmosomal glycoprotein 2/3",
        "tax_id": 9606,
        "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); hereditary spastic paraplegia 75 (Disease Ontology:DOID:0110820); sciatic neuropathy (Disease Ontology:DOID:11446); multiple sclerosis (Disease Ontology:DOID:2377); middle cerebral artery infarction (Disease Ontology:DOID:3525); nerve compression syndrome (Disease Ontology:DOID:573)",
        "pathway": " (hsa:1823);  (R-HSA-6798695);  (R-HSA-6805567);  (R-HSA-6809371)",
        "pathway_count": 4,
        "publication_count": 97,
        "publication_id_list": "10066784;10196183;10231017;10411887;10588656;10771479;11027496;11350120;11380615;11590230;12902340;15033990;15337775;15373777;15797384;15803139;16061697;16382671;16639001;1691188;1694855;1713860;1714783;17487921;17515931;17521629;17562024;17596512;17924679;18452278;18843291;19190773;19194479;19759396;20179351;20657595;20667819;20940292;21439340;21654840;21997417;23481192;23629652;23650620;2414304;24715725;25208914;25576301;25880248;25926655;26374642;26375851;26390218;26811146;27452731;28218747;28855257;29314611;29317506;29393594;30397120;30524438;30833945;31092671;31154438;31222486;31617665;31844290;32350084;32488085;32983136;33043033;33592498;33637694;33968037;34078123;34171305;34211107;34454985;35051231;35251023;35561310;36010968;36215666;37217939;37620794;37938771;38665916;7543090;8288219;8507556;8692836;8824274;8999895;9395522;9468612;9565599",
        "class_list": "",
        "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for desmosome adhesion strength between the granular layers of the epidermis, as a result moderates epidermal proliferation and differentiation (By similarity). Is therefore required to maintain postnatal epidermal barrier function and normal hair follicle morphology into adulthood (By similarity)., [UniProtKB, UniProtKB]; CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129. Publication Status: Online-Only, [RefSeq, PubMed]; Desmocollin-1 (DSC1) is validated as a protein connected with lymph node status of luminal A breast cancer, tumor grade, and Her-2 status and catechol-O-methyltransferase is successfully verified as a protein associated with lymph node metastasis of triple negative breast cancer., [RefSeq, PubMed]; Desmocollin-1 is associated with pro-metastatic phenotype of luminal A breast cancer cells and is modulated by parthenolide. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein. [provided by RefSeq, Nov 2015]., [RefSeq]; Uniting biobank resources reveals novel genetic pathways modulating susceptibility for atopic dermatitis., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 6,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 42,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9HB01",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0101003 ficolin-1-rich granule membrane;GO:0001533 cornified envelope",
        "go_biological_process": "GO:0061436 establishment of skin barrier;GO:0050680 negative regulation of epithelial cell proliferation;GO:0098609 cell-cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0031069 hair follicle morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 10.7,
        "record_id": "Q08554-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0CAP1-1",
        "uniprot_id": "MYZAP_HUMAN",
        "mass": 54206.0,
        "length": 466,
        "protein_name": "Myocardial zonula adherens protein",
        "gene_name": "MYZAP",
        "organism": "Human",
        "refseq_name": "GRINL1A combined protein isoform 1",
        "refseq_ac": "NP_001018100",
        "gene_names_uniprotkb": "MYZAP; MYOZAP",
        "gene_names_refseq": "GCOM1; GRINL1A; Gcom2; MYZAP-POLR2M; gcom",
        "protein_names_uniprotkb": "Myocardial zonula adherens protein; GRINL1A upstream protein; Gup",
        "protein_names_refseq": "DNA-directed RNA polymerase II subunit GRINL1A; DNA-directed RNA polymerase II subunit M; GRINL1A combined protein Gcom12; GRINL1A combined protein isoform 1; GRINL1A complex locus 1; Glutamate receptor-like protein 1A; MYZAP-POLR2M readthrough; NMDAR1 subunit-interacting protein; glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A combined protein; myocardial zonula adherens protein",
        "tax_id": 9606,
        "disease": "cardiomyopathy, dilated, 2K (MONDO:MONDO:0971175)",
        "pathway": " (hsa:100820829);  (hsa:145781)",
        "pathway_count": 2,
        "publication_count": 20,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;15233991;18849881;20093627;20412299;21240187;29034528;29242379;29339073;29557506;31154438;33592498;33968037;34899865;35051231;35580925;35840178;37217939;38436102",
        "class_list": "",
        "function": "Genetic and transcriptional organization of gene, [RefSeq, PubMed]; Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity)., [UniProtKB]; Reveal myozap as a previously unrecognized component of a Rho-dependent signaling pathway that links the intercalated disc to cardiac gene regulation., [RefSeq, PubMed]; This locus represents naturally occurring readthrough transcription between the neighboring MYZAP (myocardial zonula adherens protein) and POLR2M (polymerase (RNA) II (DNA directed) polypeptide M) genes on chromosome 15. Alternative splicing results in multiple readthrough transcript variants. Readthrough variants may encode proteins that share sequence identity with the upstream gene product or with both the upstream and downstream gene products. Some readthrough transcript variants are also expected to be candidates for nonsense-mediated decay (NMD). [provided by RefSeq, Oct 2013]., [RefSeq]; Yeast two-hybrid (Y2H) screens indicate 27 novel GRINL1A complex locus 1 (GCOM1) interacting genes, many of which are synaptic proteins and/or play roles in neurologic diseases., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D2E9U7;Q6EER8;Q6EES2;Q6EEV3;Q6EF00;Q6EF01;Q6EF02;Q6EF46;Q6EFN8;Q6EM48;Q6K046;Q6K050;Q6K051;Q6ZQZ3;Q8NC58;Q8NCF3;Q96DI5;Q96JB7;Q96NF5",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0031674 I band;GO:0009898 cytoplasmic side of plasma membrane;GO:0030018 Z disc;GO:0030864 cortical actin cytoskeleton;GO:0005665 RNA polymerase II, core complex",
        "go_biological_process": "GO:0035556 intracellular signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "P0CAP1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5T5U3-1",
        "uniprot_id": "RHG21_HUMAN",
        "mass": 217462.0,
        "length": 1958,
        "protein_name": "Rho GTPase-activating protein 21",
        "gene_name": "ARHGAP21",
        "organism": "Human",
        "refseq_name": "rho GTPase-activating protein 21 isoform a",
        "refseq_ac": "NP_065875",
        "gene_names_uniprotkb": "ARHGAP21; ARHGAP10; KIAA1424",
        "gene_names_refseq": "ARHGAP10; ARHGAP21",
        "protein_names_uniprotkb": "Rho GTPase-activating protein 21; Rho GTPase-activating protein 10; Rho-type GTPase-activating protein 21",
        "protein_names_refseq": "Rho-GTPase activating protein 10; rho GTPase-activating protein 10; rho GTPase-activating protein 21 isoform a; rho GTPase-activating protein 21; rho-type GTPase-activating protein 21",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57584);  (R-HSA-8980692);  (R-HSA-9013026);  (R-HSA-9013106);  (R-HSA-9013148);  (R-HSA-9013149);  (R-HSA-9013404);  (R-HSA-9013405);  (R-HSA-9013406);  (R-HSA-9013408);  (R-HSA-9013409);  (R-HSA-9013423);  (R-HSA-9035034);  (R-HSA-9696264)",
        "pathway_count": 14,
        "publication_count": 459,
        "publication_id_list": "10037681;10232922;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10618392;10619026;10652265;10699171;10699464;10724160;10847683;10873388;10873802;10958683;10967094;11007481;11058585;11085924;11145705;11149925;11185749;11207612;11237011;11306516;11373293;11396949;11431473;11432776;11584276;11606631;11672528;11680691;11689693;11696321;11704860;11707441;11756552;11773441;11784792;11803464;11804587;11804589;11804590;11864571;11884391;11912491;11919634;11940653;11948177;11956649;11961559;11967128;12056806;12071859;12093360;12096337;12172552;12177196;12195014;12221077;12221096;12242347;12351724;12376551;12432077;12456725;12464619;12473120;12531887;12546821;12547822;12577064;12650940;12665586;12773384;12842009;12857875;12860998;12877655;12907671;12923183;14506234;14512443;14514689;1464587;14675773;14718541;15023524;15033976;15064355;15107133;15133129;15147912;15157669;15169870;15260990;15302923;15304341;15339924;15342493;15375573;15485661;15507211;15542837;15546864;15579468;15601624;15611138;15710388;15728722;15738000;15793564;15814684;15850391;15858067;15866170;15897194;15944396;16002401;16081809;16112081;16116428;16184169;16217026;16243035;16243036;16261155;16339170;16467373;16473593;16492808;16507994;16519628;16527809;1660188;16630611;16636067;16702231;16714282;16762923;16776779;16777452;16777849;16862148;16896804;16914516;16917499;16968698;17027967;17060455;17064668;17077126;17081983;17145773;17158234;17196961;17198702;17214551;17244649;17269730;17347647;17562871;17583407;17599059;17698854;17702745;17765681;17804252;17916560;17932950;17942708;17976533;18006505;18045877;18056264;18158243;18191593;18212344;18218625;18220336;18249095;18347018;18363964;18396277;18426980;18452278;18653540;18662984;18669648;18697831;18767875;18786931;18802007;18829452;18835169;18838382;18929667;18996843;19258391;19269969;19413330;19494238;19534724;19581409;19605563;19635168;19651622;19664994;19673492;19691289;19713215;19934221;20030946;20068231;20101212;20233848;20400958;20460433;20591975;20628200;20660154;20679435;20810653;20811643;21119010;21148482;21151158;21351730;21373644;21378159;21454492;21542010;21565175;21576392;21613211;21621533;21685891;21699497;21730051;21757538;21865595;21936715;21989057;22004470;22096251;22298643;22305756;22407364;22461490;22475431;22571869;22608513;22665057;22673745;22734669;22790947;22911862;22922005;22970203;22971344;22992742;23029280;23087206;23096567;23186163;23200924;23209303;23255595;23288169;23406282;23434736;23481700;23572525;23707487;23718289;23757206;23870057;23870313;23940355;24086303;24102721;24128008;24129315;24259668;24275569;24297911;24335996;24352656;24355937;24584464;24623723;24659802;24859002;24933155;24960694;24996924;25024229;25211221;25425145;25428919;25576301;25645385;25668492;25673874;25678704;25704760;25721503;25746724;25795300;25862245;25963737;26016997;26129894;26299518;26371245;26375851;26529257;26598554;26628301;26887924;26969432;27096001;27117132;27145964;27216196;27278019;27481945;27555588;27566826;27713499;27798618;27806292;27852748;27986909;28028151;28112683;28114311;28196833;28218747;28356423;28486133;28584191;28825699;28832583;28860633;28947137;29089502;29146911;29237092;29242379;29358323;29382922;29393594;29493099;29557506;29632046;29776664;29786170;30059200;30061681;30379171;30524438;30853411;31105010;31217245;31389670;31492838;31844290;31871319;32157095;32203420;32302585;32350084;32897882;32938616;32938750;32983136;33592498;33912179;33968037;33981976;35051231;35254053;35318648;35494241;35580925;36010968;36241641;36676763;36764390;37340703;37541260;37712268;38665916;39531497;39534244;7476457;7479768;7512369;7559638;7673236;7721814;7753201;7835339;8021274;8107774;8537347;8543060;8571126;8617235;8643598;8645157;8649376;8649427;8662891;8670801;8756646;8769096;8798539;8805223;8807639;8810315;8816443;8939998;8945468;8990121;8994827;9013646;9099726;9111050;9113980;9252344;9268338;9305890;9405671;9418861;9438849;9490638;9497316;9535835;9548756;9582072;9659915;9670022;9705280;9792683;9822598;9822605;9829970;9843499;9846874;9857026;9988689",
        "class_list": "",
        "function": "ARHGAP10 gene is highly expressed in muscle and brain, which are highly differentiated tissues. It supports the hypothesis that ARHGAP10 is important for cell differentiation, [RefSeq, PubMed]; ARHGAP21 Is Involved in the Carcinogenic Mechanism of Cholangiocarcinoma: A Study Based on Bioinformatic Analyses and Experimental Validation. Publication Status: Online-Only, [RefSeq, PubMed]; ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]., [RefSeq]; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Silencing of ARHGAP21, a Rho GTPase activating protein (RhoGAP), reduces the growth of prostate cancer xenografts in NOD/SCID mice., [RefSeq, PubMed]; The ARHGAP10 protein is a novel Rho GTPase-activating protein (Rho-GAP) that is recruited to Golgi membranes through binding to GTP-ARF1., [RefSeq, PubMed]; The crystal structure of the activated GTP-bound form of ARF1 in a complex with the Arf-binding domain (ArfBD) of ARHGAP21 at 2.1 A resolution, is presented., [RefSeq, PubMed]; [ARHGAP21 inhibits epithelial-mesenchymal transition by inactivating the WNT signaling pathway in non-small cell lung cancer]., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 54,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 58,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q0VF98;Q7Z3P7;Q8N3A2;Q8NI19;Q8TBV5;Q9P2C3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005096 GTPase activator activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton",
        "go_biological_process": "GO:0051684 maintenance of Golgi location;GO:0007165 signal transduction;GO:0051056 regulation of small GTPase mediated signal transduction;GO:0051683 establishment of Golgi localization;GO:0007030 Golgi organization",
        "synthesized_glycan_count": 0,
        "hit_score": 46.8,
        "record_id": "Q5T5U3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y4L5-1",
        "uniprot_id": "RN115_HUMAN",
        "mass": 33703.0,
        "length": 304,
        "protein_name": "E3 ubiquitin-protein ligase RNF115",
        "gene_name": "RNF115",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase RNF115",
        "refseq_ac": "NP_055270",
        "gene_names_uniprotkb": "RNF115; ZNF364",
        "gene_names_refseq": "BCA2; RABRING7; RNF115; ZFP364; ZNF364",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF115; 2.3.2.27; RING finger protein 115; RING-type E3 ubiquitin transferase RNF115; Rab7-interacting RING finger protein; Rabring 7; Zinc finger protein 364",
        "protein_names_refseq": "Breast cancer-associated gene 2; E3 ubiquitin-protein ligase RNF115; RING-type E3 ubiquitin transferase RNF115; rab7-interacting RING finger protein; rabring 7; zinc finger protein 364",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:27246);  (R-HSA-983168)",
        "pathway_count": 2,
        "publication_count": 62,
        "publication_id_list": "11062501;11350924;12646216;14734113;15224091;15224092;15571818;16288031;16595681;16849449;16925951;16954532;18662542;18819927;19028597;19352404;19452197;19489725;19851334;19874575;19940261;20019814;2261476;23418353;24714562;24715725;24852021;25576301;26154972;26992070;27846572;27862975;27920218;28218747;28228285;28832583;28834231;29242379;29437277;29557506;30315122;30410026;30429286;30689267;31844290;32157095;32980859;32983136;33139700;33298915;33633747;33912179;34357683;35051231;35343654;36215666;36241641;36284347;38376606;38725852;9380723;9668046",
        "class_list": "",
        "function": "BCA2 E3 ligase is coregulated with estrogen receptor and plays a role in the regulation of epidermal growth factor receptor (EGF-R) trafficking Review article, [RefSeq, PubMed]; E3 ubiquitin ligase BCA2 promotes breast cancer stemness by up-regulation of SOX9 by LPS. Publication Status: Online-Only, [RefSeq, PubMed]; E3 ubiquitin-protein ligase that catalyzes the 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of various substrates and thereby plays a role in a number of signaling pathways including autophagy, innate immunity, cell proliferation and cell death (PubMed:20019814, PubMed:30689267). Plays a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4 through their polyubiquitination. Participates together with BST2 in antiviral immunity by facilitating the internalization of HIV-1 virions into intracellular vesicles leading to their lysosomal degradation (PubMed:20019814). Also possesses an antiviral activity independently of BST2 by promoting retroviral GAG proteins ubiquitination, redistribution to endo-lysosomal compartments and, ultimately, lysosomal degradation (PubMed:24852021). Catalyzes distinct types of ubiquitination on MAVS and STING1 at different phases of viral infection to promote innate antiviral response (PubMed:33139700). Mediates the 'Lys-48'-linked ubiquitination of MAVS leading to its proteasomal degradation and ubiquitinates STING1 via 'Lys-63'-linked polyubiquitination, critical for its oligomerization and the subsequent recruitment of TBK1 (PubMed:33139700). Plays a positive role in the autophagosome-lysosome fusion by interacting with STX17 and enhancing its stability without affecting 'Lys-48'- or 'Lys-63'-linked polyubiquitination levels, which in turn promotes autophagosome maturation (PubMed:32980859). Negatively regulates TLR-induced expression of proinflammatory cytokines by catalyzing 'Lys-11'-linked ubiquitination of RAB1A and RAB13 to inhibit post-ER trafficking of TLRs to the Golgi by RAB1A and subsequently from the Golgi apparatus to the cell surface by RAB13 (PubMed:35343654)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; RNF115 aggravates tumor progression through regulation of CDK10 degradation in thyroid carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; The autoubiquitination activity of BCA2 indicates that it is a novel RING-type E3 ligase., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K3Y4;Q5T2V9;Q7Z2J2",
        "ec_number_list": "2.3.2.24;2.3.2.23;2.3.2.26;2.3.2.27;2.3.2.31;2.3.2.-;6.2.1.-;2.3.2.34;2.3.2.32;3.6.4.-;2.3.2.25;2.3.2.36;2.7.11.1",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol",
        "go_biological_process": "GO:0016567 protein ubiquitination;GO:0070979 protein K11-linked ubiquitination;GO:0051865 protein autoubiquitination;GO:0070936 protein K48-linked ubiquitination;GO:0034122 negative regulation of toll-like receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "Q9Y4L5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q93073-1",
        "uniprot_id": "SBP2L_HUMAN",
        "mass": 121776.0,
        "length": 1101,
        "protein_name": "Selenocysteine insertion sequence-binding protein 2-like",
        "gene_name": "SECISBP2L",
        "organism": "Human",
        "refseq_name": "selenocysteine insertion sequence-binding protein 2-like isoform 1",
        "refseq_ac": "NP_001180418",
        "gene_names_uniprotkb": "SECISBP2L; KIAA0256",
        "gene_names_refseq": "SBP2L; SECISBP2L; SLAN",
        "protein_names_uniprotkb": "Selenocysteine insertion sequence-binding protein 2-like; SECIS-binding protein 2-like",
        "protein_names_refseq": "selenocysteine insertion sequence-binding protein 2-like isoform 1; selenocysteine insertion sequence-binding protein 2-like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9728)",
        "pathway_count": 1,
        "publication_count": 68,
        "publication_id_list": "11237011;21566536;22530054;23481700;24714562;24715725;25576301;25880248;25892735;26154972;26992070;27600516;27846572;27920218;28228285;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632711;29769354;29786170;30315122;30410026;30429286;30779550;30833945;31154438;31222486;31314582;31324691;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33592498;33691108;33717175;33912179;33968037;33981976;34171305;34211107;34509645;34932366;35051231;35318648;35580925;36010968;36241641;36284347;37938771;38253038",
        "class_list": "",
        "function": "Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro., [UniProtKB]; SECISBP2L (SBP2L) interacts with all known human SECIS RNAs in vitro and selenoprotein mRNAs co-immunoprecipitate with endogenous SBP2L, suggesting a role in regulating selenoprotein expression., [RefSeq, PubMed]; SLAN mediates the Aurora-A-triggered cytokinesis bypass and SLAN plays dual roles in that process depending on its phosphorylation status., [RefSeq, PubMed]; SLAN, also known as KIAA0256. The novel protein suppressed in lung cancer down-regulated in lung cancer tissues retards cell proliferation and inhibits the oncokinase Aurora-A., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N767",
        "ec_number_list": "",
        "go_molecular_function": "GO:0035368 selenocysteine insertion sequence binding;GO:0003723 RNA binding;GO:0043021 ribonucleoprotein complex binding;GO:0003730 mRNA 3'-UTR binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:1990904 ribonucleoprotein complex",
        "go_biological_process": "GO:0001514 selenocysteine incorporation",
        "synthesized_glycan_count": 0,
        "hit_score": 7.1,
        "record_id": "Q93073-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WVP5-1",
        "uniprot_id": "TP8L1_HUMAN",
        "mass": 20827.0,
        "length": 186,
        "protein_name": "Tumor necrosis factor alpha-induced protein 8-like protein 1",
        "gene_name": "TNFAIP8L1",
        "organism": "Human",
        "refseq_name": "tumor necrosis factor alpha-induced protein 8-like protein 1",
        "refseq_ac": "NP_001161414",
        "gene_names_uniprotkb": "TNFAIP8L1",
        "gene_names_refseq": "TIPE1; TNFAIP8L1",
        "protein_names_uniprotkb": "Tumor necrosis factor alpha-induced protein 8-like protein 1; Oxidative stress-regulated gene-beta; Oxy-beta; TIPE1; TNF alpha-induced protein 8-like protein 1; TNFAIP8-like protein 1",
        "protein_names_refseq": "TNF alpha-induced protein 8-like protein 1; TNFAIP8-like protein 1; oxidative stress-regulated gene-beta; oxy-beta; tumor necrosis factor alpha-induced protein 8-like protein 1; tumor necrosis factor, alpha induced protein 8 like 1; tumor necrosis factor, alpha-induced protein 8-like protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:126282);  (R-HSA-1483255)",
        "pathway_count": 2,
        "publication_count": 47,
        "publication_id_list": "21600655;21924498;24444419;25043299;25242044;25314070;25479791;26154972;26375851;26728094;26992070;27846572;27862975;27920218;28063628;28832583;28994231;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30429286;31154438;31844290;31848261;31998317;32157095;32265295;32387766;32502341;32897882;32938616;32983136;33895911;33912179;34932366;35051231;35135809;35580925;36151091;36495466;37938771;38065896",
        "class_list": "",
        "function": "A pan-cancer analysis of TNFAIP8L1 in human tumors., [RefSeq, PubMed]; Acts as a negative regulator of mTOR activity., [UniProtKB, UniProtKB]; High levels of TIPE1 (TNFAIP8-like 1) mRNA were detected in most human carcinoma cell lines, especially in cells transformed with viral genomes, [RefSeq, PubMed]; Human tumor necrosis factor alpha-induced protein eight-like 1 exhibited potent anti-tumor effect through modulation of proliferation, survival, migration and invasion of lung cancer cells., [RefSeq, PubMed]; Oxidative stress induces Tnfaip8 l1/Oxi-beta, which results in increased autophagy by its exclusive binding with FBXW5 to stabilize TSC2, [RefSeq, PubMed]; Phosphoinositide-Binding Protein TIPE1 Promotes Alternative Activation of Macrophages and Tumor Progression via PIP3/Akt/TGFbeta Axis., [RefSeq, PubMed]; TIPE1 induced apoptosis in HCC cells by negatively regulating Rac1 pathway, [RefSeq, PubMed]; TIPE1 inhibits osteosarcoma tumorigenesis and progression by regulating PRMT1 mediated STAT3 arginine methylation. Publication Status: Online-Only, [RefSeq, PubMed]; TIPE1 inhibits the growth of Ewing's sarcoma cells by suppressing Wnt/beta-catenin signaling., [RefSeq, PubMed]; The levels of TIPE1 were significantly reduced and inversely correlated with differentiation status and distant metastasis in primary gastric cancer tissues., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D6W627",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0032007 negative regulation of TOR signaling;GO:0042981 regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q8WVP5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P01282-1",
        "uniprot_id": "VIP_HUMAN",
        "mass": 19169.0,
        "length": 170,
        "protein_name": "VIP peptides",
        "gene_name": "VIP",
        "organism": "Human",
        "refseq_name": "VIP peptides isoform 1 preproprotein",
        "refseq_ac": "NP_003372",
        "gene_names_uniprotkb": "VIP",
        "gene_names_refseq": "PHM27; VIP",
        "protein_names_uniprotkb": "VIP peptides; PHM-27; PHV-42; Peptide histidine methioninamide 27; Peptide histidine valine 42; Vasoactive intestinal polypeptide",
        "protein_names_refseq": "VIP peptides isoform 1 preproprotein; VIP peptides; prepro-VIP",
        "tax_id": 9606,
        "disease": "Parkinsonism (Disease Ontology:DOID:0080855); uveitis (Disease Ontology:DOID:13141); pulmonary sarcoidosis (Disease Ontology:DOID:13406); Parkinson's disease (Disease Ontology:DOID:14330); primary pulmonary hypertension (Disease Ontology:DOID:14557); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); pulmonary hypertension (Disease Ontology:DOID:6432); ankylosing spondylitis (Disease Ontology:DOID:7147); periodontitis (Disease Ontology:DOID:824); ulcerative colitis (Disease Ontology:DOID:8577)",
        "pathway": " (hsa:7432);  (R-HSA-418555);  (R-HSA-420092)",
        "pathway_count": 3,
        "publication_count": 97,
        "publication_id_list": "10322410;10698200;11007482;11060443;11237011;11946536;12036966;12058044;12106601;12180353;12860470;1318039;1333056;13549488;1377678;14671004;15013843;1517224;15464082;15471943;15765929;15769620;15951850;16313925;16687412;16923326;17168849;1739432;18044684;18577758;18603306;1863695;19105585;19615748;19876791;19929708;20381629;21036126;2163110;2417744;2434617;24687066;2491850;2553411;2553705;26417854;2826231;2839091;2871555;29443750;29557506;29602314;29789417;2995945;3025882;30833991;3127824;31279028;31399091;31983287;32226383;32497535;32540603;32618402;32715661;33049737;34185709;3456568;35051231;35216459;35443019;36385145;3654650;36768369;3748844;38674298;3899557;6085243;6139527;6192430;6571696;6745415;7589426;7680413;7700244;7811244;7902709;8144028;8340388;8390245;8514797;8672451;8933357;9263355;9417641;9651336;9990065",
        "class_list": "",
        "function": "Bioactive forms that cause vasodilation (PubMed:15013843, PubMed:3654650)., [UniProtKB, PubMed, PubMed]; Bioactive forms that cause vasodilation (PubMed:15013843, PubMed:3654650). PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin (PubMed:15013843)., [UniProtKB, PubMed, PubMed]; Donor plasmacytoid dendritic cells limit graft-versus-host disease through vasoactive intestinal polypeptide expression., [RefSeq, PubMed]; Effects of the Neuropeptides Pituitary Adenylate Cyclase Activating Polypeptide and Vasoactive Intestinal Peptide in Male Fertility. Publication Status: Online-Only, [RefSeq, PubMed]; Human CD4(+)CD45RA(+) T Cells Behavior after In Vitro Activation: Modulatory Role of Vasoactive Intestinal Peptide. Publication Status: Online-Only, [RefSeq, PubMed]; Sympathetic System in Wound Healing: Multistage Control in Normal and Diabetic Skin. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The antimicrobial peptide, VIP is a neuropeptide with activity against a range of microorganisms from skin, oral, respiratory and gastrointestinal tract sites., [RefSeq, PubMed]; The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2014]., [RefSeq]; VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles. Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 13,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5TCY8;Q5TCY9;Q96QK3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding;GO:0031891 type 1 vasoactive intestinal polypeptide receptor binding;GO:0031892 type 2 vasoactive intestinal polypeptide receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0043005 neuron projection",
        "go_biological_process": "GO:0048242 epinephrine secretion;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0048255 mRNA stabilization",
        "synthesized_glycan_count": 0,
        "hit_score": 9.8,
        "record_id": "P01282-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7L2R6-1",
        "uniprot_id": "ZN765_HUMAN",
        "mass": 61633.0,
        "length": 523,
        "protein_name": "Zinc finger protein 765",
        "gene_name": "ZNF765",
        "organism": "Human",
        "refseq_name": "zinc finger protein 765 isoform 1",
        "refseq_ac": "NP_001035275",
        "gene_names_uniprotkb": "ZNF765",
        "gene_names_refseq": "ZNF765",
        "protein_names_uniprotkb": "Zinc finger protein 765",
        "protein_names_refseq": "zinc finger protein 765 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91661);  (R-HSA-9843940)",
        "pathway_count": 2,
        "publication_count": 33,
        "publication_id_list": "10330177;11237011;11959841;12869583;14536086;15882967;16567619;16954381;18082607;2028256;25274305;26813693;28273063;28832583;28834231;29242379;29493099;30379171;30429286;31154438;31289231;31427381;31844290;31848261;32157095;32387766;32713259;32938616;34932366;36010968;39894887;8769649;9016654",
        "class_list": "",
        "function": "IGF2BP2 stabilized FBXL19-AS1 regulates the blood-tumour barrier permeability by negatively regulating ZNF765 by STAU1-mediated mRNA decay., [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MYG0;B4DF18;B7ZAI5;B9EIL1;Q9BV49",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0031981 nuclear lumen;GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "Q7L2R6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95402-1",
        "uniprot_id": "MED26_HUMAN",
        "mass": 65446.0,
        "length": 600,
        "protein_name": "Mediator of RNA polymerase II transcription subunit 26",
        "gene_name": "MED26",
        "organism": "Human",
        "refseq_name": "mediator of RNA polymerase II transcription subunit 26",
        "refseq_ac": "NP_004822",
        "gene_names_uniprotkb": "MED26; ARC70; CRSP7",
        "gene_names_refseq": "CRSP70; CRSP7; MED26",
        "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 26; ARC70; Activator-recruited cofactor 70 kDa component; CRSP complex subunit 7; Cofactor required for Sp1 transcriptional activation subunit 7; Mediator complex subunit 26; Transcriptional coactivator CRSP70",
        "protein_names_refseq": "ARC70; CRSP complex subunit 7; activator-recruited cofactor 70 kDa component; cofactor required for Sp1 transcriptional activation subunit 7; cofactor required for Sp1 transcriptional activation, subunit 7 (70kD); cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa; mediator of RNA polymerase II transcription subunit 26; transcriptional coactivator CRSP70",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9441);  (R-HSA-1989781);  (R-HSA-212436);  (R-HSA-381340);  (R-HSA-9833110)",
        "pathway_count": 5,
        "publication_count": 126,
        "publication_id_list": "10075656;10235266;10235267;10330177;10425206;10777541;11095972;11237011;11267664;11395415;11607032;11872672;12050112;12118000;12177166;12213831;12505311;12582161;12829629;14519192;14976261;15067378;15130092;15175151;15175163;15273253;15635043;15850785;15896744;15919796;15989967;16380219;16606702;16719718;16972786;17011499;17081983;17980149;18420935;18452278;18540824;18669648;18719978;18848529;18931025;19043829;19088433;19115207;19172745;19710929;19934321;20068231;20101261;20110263;20111005;20410276;2163759;22090124;23186163;23239344;23481700;24196956;24397554;24715725;25854864;26154972;26811146;26861138;26992070;27600516;27846572;27862975;27920218;28352266;28832583;28834231;28893534;28904123;29242379;29393594;29557506;29632046;29789417;30315122;30779550;30833945;31530632;31844290;31848261;32157095;32265295;32357974;32387766;32488085;32502341;32983136;33141586;33298915;33392160;33537174;33912179;34171305;34932366;35051231;35318648;35561310;35580925;36102648;7685352;7892212;8183939;8325954;8643605;8647822;8706692;8769649;8770873;8970730;9012850;9065481;9454824;9637681;9653119;9748239;9836620;9989412",
        "class_list": "",
        "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB, UniProtKB]; EAF1 (239-268) and TAF7 (205-235) peptide interactions were both mapped to the same groove formed by H3 and H4 helices of MED26 N-terminal domain., [RefSeq, PubMed]; Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation, [RefSeq, PubMed]; The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1A4S3;Q0VGB6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003712 transcription coregulator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016592 mediator complex;GO:0070847 core mediator complex",
        "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0032968 positive regulation of transcription elongation by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 12.7,
        "record_id": "O95402-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UIA0-1",
        "uniprot_id": "CYH4_HUMAN",
        "mass": 45672.0,
        "length": 394,
        "protein_name": "Cytohesin-4",
        "gene_name": "CYTH4",
        "organism": "Human",
        "refseq_name": "cytohesin-4 isoform 2",
        "refseq_ac": "NP_001304953",
        "gene_names_uniprotkb": "CYTH4; CYT4; PSCD4",
        "gene_names_refseq": "CYT4; CYTH4; DJ63G5.1; PSCD4; cytohesin-4",
        "protein_names_uniprotkb": "Cytohesin-4; PH, SEC7 and coiled-coil domain-containing protein 4",
        "protein_names_refseq": "PH, SEC7 and coiled-coil domain-containing protein 4; cytohesin-4 isoform 2; pleckstrin homology, Sec7 and coiled/coil domains 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:27128);  (R-HSA-6811438)",
        "pathway_count": 2,
        "publication_count": 79,
        "publication_id_list": "10189370;10652308;10652516;11237011;11718716;11748249;12011112;12383348;12429822;15302935;15504911;15718469;15728195;15758030;17274799;17398095;18086915;18256213;18451304;18477386;19164740;19536132;19715559;20163571;20874812;21807881;22013193;22188167;23091056;23239882;23378023;23462996;23839779;23936529;23940353;24119662;25240857;25418920;25708460;25880248;25892735;26929215;26992070;27846572;27920218;28218747;28514659;28723299;28832583;29242379;29393594;29437277;29493099;29632046;29769354;29786170;30315122;30429286;31844290;31848261;32357974;32387766;32983136;33912179;33968037;34509645;35051231;35580925;36010968;37938771;40914422;8636227;8945478;9244307;9476900;9510256;9653114;9707577;9915833",
        "class_list": "",
        "function": "Novel alleles were detected at the long extreme of the GTTT-repeat, at 10- and 11-repeats, in the Schizophrenia cases and controls.Three genotypes consisting of the 11-repeat allele (i.e., 11/11, 10/11, and 7/11) were detected only in the Schizophrenia patients. The frequency of the 11-repeat allele was estimated at 0.02 and 0.006 in the Schizophrenia patients and controls, respectively, [RefSeq, PubMed]; Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP., [UniProtKB, PubMed]; This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]., [RefSeq]; This is the first evidence of a link between a primate-specific short tandem repeat of promoter of CYTH4 and a major psychiatric disorder in human, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5R3F9;Q9UGT6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008289 lipid binding;GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0032012 regulation of ARF protein signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 8.2,
        "record_id": "Q9UIA0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UBE8-1",
        "uniprot_id": "NLK_HUMAN",
        "mass": 58283.0,
        "length": 527,
        "protein_name": "Serine/threonine-protein kinase NLK",
        "gene_name": "NLK",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein kinase NLK",
        "refseq_ac": "NP_057315",
        "gene_names_uniprotkb": "NLK; LAK1",
        "gene_names_refseq": "NLK",
        "protein_names_uniprotkb": "Serine/threonine-protein kinase NLK; 2.7.11.24; Nemo-like kinase; Protein LAK1",
        "protein_names_refseq": "serine/threonine-protein kinase NLK",
        "tax_id": 9606,
        "disease": "myocardial infarction (Disease Ontology:DOID:5844)",
        "pathway": " (hsa:51701);  (R-HSA-4086398)",
        "pathway_count": 2,
        "publication_count": 94,
        "publication_id_list": "10380924;10391246;10391247;10395542;10488343;10588714;10777564;10858654;10863097;11015615;11030334;11237011;11563835;12015605;12086864;12471263;12482967;12556497;12729560;12975316;14704854;14960582;14977528;15004007;15082531;15494017;15545263;15611108;15764709;16714285;16880514;16920709;17344846;17426020;17684012;17952062;18077418;18456304;18488142;19177143;19369195;19536106;19651622;19690332;19851316;20061393;20118921;20874444;21118996;21454679;21903638;22941947;23151663;23186163;23256519;23416699;23632248;23904219;25512613;25880248;25892735;26588989;26590425;26992070;27397612;27600516;27846572;27862975;2841328;28832583;28904123;29242379;29557506;29769354;31844290;31848261;32157095;32357974;32488085;32502341;32620751;32938616;32983136;33717175;33968037;33981976;34171305;34932366;35051231;36010968;37384409;39110129;9073455;9389482",
        "class_list": "",
        "function": "Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase. Publication Status: Online-Only, [RefSeq, PubMed]; Nemo-like kinase blocks myeloid differentiation by targeting tumor suppressor C/EBPalpha in AML., [RefSeq, PubMed]; Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination (PubMed:12482967, PubMed:14960582, PubMed:15004007, PubMed:15764709, PubMed:20061393, PubMed:20874444, PubMed:21454679). Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2 (PubMed:15004007, PubMed:15764709). Negative regulator of the canonical Wnt/beta-catenin signaling pathway (PubMed:12482967). Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1 (PubMed:21454679). Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes (PubMed:12482967, PubMed:21454679). Negative regulator of the Notch signaling pathway (PubMed:20118921). Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1 (PubMed:20118921). Negative regulator of the MYB family of transcription factors (PubMed:15082531). Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP (PubMed:15082531). Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself (PubMed:15082531). Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1 (PubMed:15004007, PubMed:15764709). Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (PubMed:25512613). Acts as an inhibitor of the mTORC1 complex in response to osmotic stress by mediating phosphorylation of RPTOR, thereby preventing recruitment of the mTORC1 complex to lysosomes (PubMed:26588989)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCX1;Q2PNI9;Q6P2A3",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;3.1.26.n2;3.6.4.13;5.6.2.5;2.7.1.150",
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0006355 regulation of DNA-templated transcription;GO:0007179 transforming growth factor beta receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 9.5,
        "record_id": "Q9UBE8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UHL9-1",
        "uniprot_id": "GT2D1_HUMAN",
        "mass": 106057.0,
        "length": 959,
        "protein_name": "General transcription factor II-I repeat domain-containing protein 1",
        "gene_name": "GTF2IRD1",
        "organism": "Human",
        "refseq_name": "general transcription factor II-I repeat domain-containing protein 1 isoform 3",
        "refseq_ac": "NP_001186136",
        "gene_names_uniprotkb": "GTF2IRD1; CREAM1; GTF3; MUSTRD1; RBAP2; WBSCR11; WBSCR12",
        "gene_names_refseq": "BEN; CREAM1; GTF2IRD1; GTF3; MUSTRD1; RBAP2; WBSCR11; WBSCR12; WBS; hMusTRD1alpha1",
        "protein_names_uniprotkb": "General transcription factor II-I repeat domain-containing protein 1; GTF2I repeat domain-containing protein 1; General transcription factor III; MusTRD1/BEN; Muscle TFII-I repeat domain-containing protein 1; Slow-muscle-fiber enhancer-binding protein; USE B1-binding protein; Williams-Beuren syndrome chromosomal region 11 protein; Williams-Beuren syndrome chromosomal region 12 protein",
        "protein_names_refseq": "USE B1-binding protein; Williams-Beuren syndrome chromosome region 11; binding factor for early enhancer; general transcription factor 3; general transcription factor II-I repeat domain-containing protein 1 isoform 3; general transcription factor II-I repeat domain-containing protein 1; general transcription factor III; muscle TFII-I repeat domain-containing protein 1 alpha 1; slow-muscle-fiber enhancer-binding protein; williams-Beuren syndrome chromosomal region 12 protein",
        "tax_id": 9606,
        "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)",
        "pathway": " (hsa:9569)",
        "pathway_count": 1,
        "publication_count": 53,
        "publication_id_list": "10198167;10573005;10575229;10642537;11237011;11438732;15302935;17081983;17525332;18452278;18669648;20068231;20112406;23186163;25114211;25218447;25576301;25755297;25772364;26992070;27600516;27920218;28834231;29393594;29508533;29557506;29786170;29884845;30429286;30524438;31758608;31844290;31848261;32157095;32161166;32350084;32502341;32897882;32936232;32938616;32983136;33592498;33936100;33968037;34171305;34211107;34932366;35051231;35318648;36010968;36241641;39534244;9774679",
        "class_list": "",
        "function": "Among 110 SNPs within the 7q11.23 William's Syndrome (WS) chromosomal region, we found one associated locus located at GTF2IRD1, which has been implicated in animal models of WS. Publication Status: Online-Only, [RefSeq, PubMed]; GTF2IRD1 overexpression promotes tumor progression and correlates with less CD8+ T cells infiltration in pancreatic cancer., [RefSeq, PubMed]; May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Study showed that GTF2IRD1 was overexpressed due to copy number amplification at Ch.7q in colorectal cancer (CRC). The expression of GTF2IRD1 was positively associated with the malignant pathological phenotype. Furthermore, high expression of GTF2IRD1 was an independent poor prognostic factor in CRC. Mechanistically, GTF2IRD1 promoted cell cycle progression by downregulation of TGFbetaR2 in CRC., [RefSeq, PubMed]; The protein encoded by this gene contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene plays a role in craniofacial and cognitive development and mutations have been associated with Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O95444;Q6DSU6;Q75MX7;Q86UM3;Q8WVC4;Q9UHK8;Q9UI91",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0006366 transcription by RNA polymerase II;GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "Q9UHL9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96HP0-1",
        "uniprot_id": "DOCK6_HUMAN",
        "mass": 229558.0,
        "length": 2047,
        "protein_name": "Dedicator of cytokinesis protein 6",
        "gene_name": "DOCK6",
        "organism": "Human",
        "refseq_name": "dedicator of cytokinesis protein 6 isoform 1",
        "refseq_ac": "NP_065863",
        "gene_names_uniprotkb": "DOCK6; KIAA1395",
        "gene_names_refseq": "AOS2; DOCK6; ZIR1",
        "protein_names_uniprotkb": "Dedicator of cytokinesis protein 6",
        "protein_names_refseq": "dedicator of cytokinesis protein 6 isoform 1; dedicator of cytokinesis protein 6",
        "tax_id": 9606,
        "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); Adams-Oliver syndrome (Disease Ontology:DOID:0060227); stomach cancer (Disease Ontology:DOID:10534)",
        "pathway": " (hsa:57572);  (R-HSA-9013148);  (R-HSA-9013149);  (R-HSA-983231)",
        "pathway_count": 4,
        "publication_count": 347,
        "publication_id_list": "10.1101/2023.09.13.557529;10232922;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10699171;10699464;10724160;10873802;10958683;11007481;11042108;11058585;11062261;11085924;11149925;11237011;11242053;11306516;11373293;11396949;11431473;11432776;11584276;11606631;11672528;11696321;11704860;11707441;11744692;11751636;11756552;11773441;11803464;11804587;11804589;11804590;11884391;11895428;11912491;11948177;11950885;11961559;12032298;12071859;12093360;12096337;12134158;12172552;12195014;12221096;12351724;12427746;12432077;12464619;12531887;12546821;12547822;12650940;12665586;12773384;12857875;12860998;12877655;12907671;12923183;14506234;14512443;14514689;1464587;14675773;14718541;15020713;15023524;15033976;15064355;15107133;15133129;15147912;15157669;15247287;15260990;15302923;15304341;15339924;15342493;15485661;15507211;15579468;15601624;15611138;15710388;15728722;15850391;15858067;15897194;16002401;16054028;16112081;16116428;16184169;16217026;16243036;1630448;16473593;16492808;16507994;16519628;16630611;16636067;16702231;16714282;16762923;16777452;16777849;16862148;16896804;16914516;16968698;17027967;17064668;17077126;17145773;17196961;17214551;17244649;17583407;17599059;17702745;17765681;17804252;17924679;17932950;17976533;18006505;18045877;18056264;18218625;18220336;18249095;18347018;18363964;18396277;18426980;18653540;18669648;18786931;18835169;18838382;18929667;19269969;19293402;19413330;19494238;19605563;19673492;19713215;19934221;20400958;20460433;20530532;20627800;20679435;20810653;21148482;21454492;21542010;21565175;21613211;21685891;21730051;21820096;21865595;218813;21989057;22004470;22096251;22298643;22407364;22461490;22475431;22571869;22608513;22734669;22970203;23186163;23200924;23209303;23255595;23288169;23406282;23434736;23481700;23572525;23707487;23718289;23940355;24086303;24259668;24275569;24335996;24352656;24584464;24859002;24933155;24960694;24996924;25024229;25211221;25418920;25428919;25645385;25704760;25721503;25795300;25862245;25880248;25963737;26129894;26154972;26299518;26529257;26598554;26811146;26845023;26887924;26992070;27096001;27117132;27145964;27216196;27481945;27555588;27566826;27713499;27798618;27806292;27846572;27862975;27920218;28028151;28114311;28196833;28218747;28825699;28860633;28904123;29089502;29242379;29358323;29382922;29508533;29557506;29769354;29786170;30061681;30315122;30429286;30524438;30853411;31844290;31871319;32157095;32203420;32357974;32387766;32502341;32938616;33091337;33298915;33392160;33592498;33633747;33912179;33936100;33968037;33981976;3409321;34171305;34185709;34211107;34357683;34405274;34742001;35051231;35241069;35254053;35580925;36010968;36601873;37938771;7479768;7512369;7559638;7673236;7721814;7753201;7835339;8021274;8107774;8537347;8543060;8643598;8645157;8649427;8662638;8662891;8670801;8756646;8769096;8798539;8805223;8810315;8816443;8816476;8939998;8990121;8994827;9013646;9065479;9099726;9113980;9230307;9268338;9305890;9326583;9331217;9405671;9422515;9438849;9490638;9497316;9582072;9659915;9670022;9792683;9822598;9829970;9843499;9846874;9927674;9988689",
        "class_list": "",
        "function": "A homozygous truncating mutation in dedicator of cytokinesis 6 gene (DOCK6) which encodes an atypical guanidine exchange factor (GEF) known to activate two members of the Rho GTPase family: Cdc42 and Rac1, was identified., [RefSeq, PubMed]; Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity)., [UniProtKB, PubMed]; Associations of ANGPTL6, DOCK6, FABP1, and PCSK9 single-nucleotide variants with hypercholesterolemia in the Polish population: a cross-sectional study., [RefSeq, PubMed]; Attenuated clinical and osteoclastic phenotypes of Paget's disease of bone linked to the p.Pro392Leu/SQSTM1 mutation by a rare variant in the DOCK6 gene. Publication Status: Online-Only, [RefSeq, PubMed]; Overexpression of DOCK6 in oral squamous cell cancer promotes cellular migration and invasion and is associated with poor prognosis., [RefSeq, PubMed]; This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 46,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6H8X5;Q7Z7P4;Q9P2F2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0035023 regulation of Rho protein signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 35.2,
        "record_id": "Q96HP0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WTS6-1",
        "uniprot_id": "SETD7_HUMAN",
        "mass": 40721.0,
        "length": 366,
        "protein_name": "Histone-lysine N-methyltransferase SETD7",
        "gene_name": "SETD7",
        "organism": "Human",
        "refseq_name": "histone-lysine N-methyltransferase SETD7 isoform 2",
        "refseq_ac": "NP_001293128",
        "gene_names_uniprotkb": "SETD7; KIAA1717; KMT7; SET7; SET9",
        "gene_names_refseq": "KMT7; SET7/9; SET7; SET9; SETD7",
        "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SETD7; 2.1.1.364; H3-K4-HMTase SETD7; Histone H3-K4 methyltransferase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7/9",
        "protein_names_refseq": "H3-K4-HMTase SETD7; SET domain containing 7, lysine methyltransferase; SET domain containing lysine methyltransferase 7; SET domain-containing protein 7; histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; histone-lysine N-methyltransferase SETD7 isoform 2; histone-lysine N-methyltransferase SETD7; lysine N-methyltransferase 7",
        "tax_id": 9606,
        "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); extrahepatic cholestasis (Disease Ontology:DOID:13619)",
        "pathway": " (hsa:80854);  (R-HSA-3214841)",
        "pathway_count": 2,
        "publication_count": 97,
        "publication_id_list": "10949293;11237011;11779497;11850410;11959841;12123582;12130538;12372304;12389038;12453418;12514135;12540855;12588998;12670868;14536086;14690610;14992727;15099517;15145825;15235609;15525938;15964846;16118227;16141209;16199523;16292313;16415881;16433545;16519522;16682010;16805913;17021013;17108971;17500065;17544230;17707229;18172012;19808676;21131967;21196496;21779408;21832073;22099308;22939622;23301498;25576301;26154972;26992070;27146893;27600516;27846572;28218747;28832583;28834231;28904123;29242379;29393594;29437277;29508533;29557506;29632711;29786170;29789417;30429286;30833945;31154438;31844290;31848261;32157095;32387766;32488085;32502341;32897882;32938616;32983136;33537174;33592498;33912179;33936100;33968037;33981976;34171305;34357683;35051231;35210392;35580925;36241641;36284347;37938771;38018874;38043199;38253038;38520914;38602631;38665916;38904013;40596516",
        "class_list": "",
        "function": "Combined SET7/9 and CDK4 inhibition act synergistically against osteosarcoma., [RefSeq, PubMed]; Crystal structure of human SET7/9 shows residues essential for catalytic activity with histone H3, [RefSeq, PubMed]; Epigenetic mechanism of SET7/9-mediated histone methylation modification in high glucose-induced ferroptosis in retinal pigment epithelial cells., [RefSeq, PubMed]; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (PubMed:11779497, PubMed:11850410, PubMed:12540855, PubMed:12588998, PubMed:16141209). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:12540855, PubMed:12588998, PubMed:16141209). Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed:12588998, PubMed:16141209). Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (PubMed:16141209). Also has methyltransferase activity toward non-histone proteins such as CGAS, GLI3, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins (PubMed:15099517, PubMed:15525938, PubMed:16415881, PubMed:27146893, PubMed:35210392). Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II (PubMed:15099517, PubMed:16415881). Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation (PubMed:15525938, PubMed:16415881, PubMed:17108971). Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (By similarity). Acts as a positive regulator of smoothened signaling by mediating methylation of full-length GLI3, increasing GLI3 ability to bind DNA (PubMed:27146893)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS., [UniProtKB, UniProtKB]; Methyltransferase Set7/9 controls PARP1 expression and regulates cisplatin response of breast cancer cells., [RefSeq, PubMed]; Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase, [RefSeq, PubMed]; SETD7 Promotes Cell Proliferation and Migration via Methylation-mediated TAF7 in Clear Cell Renal Cell Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote metastasis in pancreatic ductal adenocarcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5WWL3;Q0VAH3;Q4W5A9;Q9C0E6",
        "ec_number_list": "2.1.1.364;2.1.1.-;2.1.1.85;2.1.1.359;2.1.1.370;2.1.1.371;2.1.1.361;2.1.1.355;2.1.1.354;2.1.1.362",
        "go_molecular_function": "GO:0042054 histone methyltransferase activity;GO:0002039 p53 binding;GO:0016279 protein-lysine N-methyltransferase activity;GO:0140945 histone H3K4 monomethyltransferase activity;GO:0140938 histone H3 methyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005694 chromosome",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006974 DNA damage response;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0018026 peptidyl-lysine monomethylation",
        "synthesized_glycan_count": 0,
        "hit_score": 10.0,
        "record_id": "Q8WTS6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6P3W7-1",
        "uniprot_id": "SCYL2_HUMAN",
        "mass": 103709.0,
        "length": 929,
        "protein_name": "SCY1-like protein 2",
        "gene_name": "SCYL2",
        "organism": "Human",
        "refseq_name": "SCY1-like protein 2 isoform 1",
        "refseq_ac": "NP_001304713",
        "gene_names_uniprotkb": "SCYL2; CVAK104; KIAA1360",
        "gene_names_refseq": "AMC4; AMCNACC; CVAK104; SCYL2",
        "protein_names_uniprotkb": "SCY1-like protein 2; Coated vesicle-associated kinase of 104 kDa",
        "protein_names_refseq": "SCY1-like 2; SCY1-like protein 2 isoform 1; SCY1-like protein 2; SCY1-like, kinase-like 2; coated vesicle-associated kinase of 104 kDa",
        "tax_id": 9606,
        "disease": "arthrogryposis multiplex congenita-4 (Disease Ontology:DOID:0080980)",
        "pathway": " (hsa:55681)",
        "pathway_count": 1,
        "publication_count": 100,
        "publication_id_list": "11237011;15809293;16903783;16914521;17344846;17587408;18669648;19643732;20068231;23047923;23186163;23301498;24029068;24397554;24714562;25576301;25880248;26154972;26375851;26811146;26992070;27600516;27862975;27920218;28218747;28228285;28657654;28832583;28834231;28904123;29242379;29351928;29393594;29437277;29485866;29557506;29786170;29789417;30059200;30315122;30410026;30429286;30484775;30620550;30779550;30833945;31092671;31154438;31217245;31530632;31844290;31848261;31960134;31998317;32119511;32157095;32161166;32350084;32357974;32387766;32488085;32897882;32938616;32938750;32983136;33141586;33214551;33298915;33392160;33592498;33691108;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34357683;34509645;34725712;34932366;35051231;35132862;35138101;35318648;35513511;35580925;35705054;36010968;36241641;36284347;37938771;38665916;39302247;39531497;39534244;40307207;40596516;40914422",
        "class_list": "",
        "function": "CVAK104 binds ATP and functions in vitro as a poly-L-lysine-stimulated kinase that is capable of autophosphorylation and phosphorylating the beta2-adaptin subunit of AP2., [RefSeq, PubMed]; CVAK104 is an evolutionarily conserved protein involved in SNARE sorting that is essential for normal embryonic development, [RefSeq, PubMed]; Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system (Probable). A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed (PubMed:15809293, PubMed:16914521). By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Results suggest that SCYL2 serves as a regulatory factor for Vpu, reducing the extent of Vpu phosphorylation and consequently enhancing BST2-mediated viral restriction. Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that severe neurogenic arthrogryposis with brain malformation is the human phenotypic consequence of SCYL2 loss of function mutations., [RefSeq, PubMed]; Studies identify CVAK104 as a novel binding partner of Dishevelled (Dvl) and that CVAK104 also interacts with Fzd5., [RefSeq, PubMed]; The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]., [RefSeq]; Together, our data suggest a function for CVAK104 in clathrin-dependent pathways between the trans-Golgi network and the endosomal system., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 13,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 13,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 13,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 41,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 13,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KAB5;Q96EF4;Q96ST4;Q9H7V5;Q9NVH3;Q9P2I7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0010008 endosome membrane;GO:0030136 clathrin-coated vesicle",
        "go_biological_process": "GO:0031623 receptor internalization;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0007420 brain development;GO:0008333 endosome to lysosome transport;GO:0072583 clathrin-dependent endocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "Q6P3W7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00472-1",
        "uniprot_id": "ELL2_HUMAN",
        "mass": 72324.0,
        "length": 640,
        "protein_name": "RNA polymerase II elongation factor ELL2",
        "gene_name": "ELL2",
        "organism": "Human",
        "refseq_name": "RNA polymerase II elongation factor ELL2",
        "refseq_ac": "NP_036213",
        "gene_names_uniprotkb": "ELL2",
        "gene_names_refseq": "ELL2; MRCCAT1",
        "protein_names_uniprotkb": "RNA polymerase II elongation factor ELL2",
        "protein_names_refseq": "ELL-related RNA polymerase II, elongation factor; RNA polymerase II elongation factor ELL2; elongation factor RNA for polymerase II 2; elongation factor, RNA polymerase II, 2; metastatic renal cell carcinoma-associated transcript 1",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:22936);  (R-HSA-6807505)",
        "pathway_count": 2,
        "publication_count": 106,
        "publication_id_list": "10022900;11237011;11418481;11856838;12414730;12446457;12574128;14701755;1535687;16239144;16308568;16901896;1739980;18079403;1829677;18452278;18669648;18691976;19651622;19667075;19749764;20068231;20159561;20457598;20471948;2125285;21406692;22137580;22195968;22231121;22252320;22441827;22483617;22895430;23166507;23251033;23481700;23932780;24097444;24270878;24715725;24997600;25418920;25576301;25675981;26154972;26375851;26992070;27397612;27600516;27846572;27920218;28228285;28446606;28832583;28904123;29242379;29331515;29393594;2944599;29493099;29557506;29741879;30315122;31154438;31217245;31844290;31848261;31937595;32157095;32161166;32357974;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33691108;33717175;33912179;33968037;34265249;34561969;34932366;34948391;35051231;35318648;35580925;36010968;36241641;36284347;7715707;8253082;8339931;8628262;8668525;9009278;9108030;9153304;9188510;9407024;9705341;9832505",
        "class_list": "",
        "function": "Allosteric transcription stimulation by RNA polymerase II super elongation complex., [RefSeq, PubMed]; Characterizing the Interaction between the HTLV-1 Transactivator Tax-1 with Transcription Elongation Factor ELL2 and Its Impact on Viral Transactivation. Publication Status: Online-Only, [RefSeq, PubMed]; ELL2 addition regulates mRNA processing by enhancing poly(A) site choice and exon splice-site skipping, [RefSeq, PubMed]; Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 8796,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DNK7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000987 cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0008023 transcription elongation factor complex",
        "go_biological_process": "GO:1905382 positive regulation of snRNA transcription by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0042795 snRNA transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 11.1,
        "record_id": "O00472-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00487-1",
        "uniprot_id": "PSDE_HUMAN",
        "mass": 34577.0,
        "length": 310,
        "protein_name": "Ubiquitin C-terminal hydrolase PSMD14",
        "gene_name": "PSMD14",
        "organism": "Human",
        "refseq_name": "ubiquitin C-terminal hydrolase PSMD14",
        "refseq_ac": "NP_005796",
        "gene_names_uniprotkb": "PSMD14; POH1",
        "gene_names_refseq": "PAD1; POH1; PSMD14; RPN11",
        "protein_names_uniprotkb": "Ubiquitin C-terminal hydrolase PSMD14; 26S proteasome non-ATPase regulatory subunit 14; 26S proteasome regulatory subunit RPN11; 26S proteasome-associated PAD1 homolog 1; 3.4.19.12",
        "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 14; 26S proteasome regulatory subunit rpn11; 26S proteasome-associated PAD1 homolog 1; proteasome (prosome, macropain) 26S subunit, non-ATPase, 14; testis tissue sperm-binding protein Li 69n; ubiquitin C-terminal hydrolase PSMD14",
        "tax_id": 9606,
        "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658)",
        "pathway": " (hsa:10213);  (R-HSA-1169091);  (R-HSA-1234176);  (R-HSA-1236974);  (R-HSA-1236978);  (R-HSA-174084);  (R-HSA-174113);  (R-HSA-174154);  (R-HSA-174178);  (R-HSA-174184);  (R-HSA-180534);  (R-HSA-180585);  (R-HSA-187577);  (R-HSA-195253);  (R-HSA-202424);  (R-HSA-211733);  (R-HSA-2467813);  (R-HSA-2871837);  (R-HSA-349425);  (R-HSA-350562);  (R-HSA-382556);  (R-HSA-450408);  (R-HSA-4608870);  (R-HSA-4641257);  (R-HSA-4641258);  (R-HSA-5358346);  (R-HSA-5362768);  (R-HSA-5607761);  (R-HSA-5607764);  (R-HSA-5610780);  (R-HSA-5610783);  (R-HSA-5610785);  (R-HSA-5632684);  (R-HSA-5658442);  (R-HSA-5668541);  (R-HSA-5676590);  (R-HSA-5678895);  (R-HSA-5687128);  (R-HSA-5689603);  (R-HSA-5689880);  (R-HSA-5689901);  (R-HSA-6798695);  (R-HSA-68867);  (R-HSA-68949);  (R-HSA-69017);  (R-HSA-69481);  (R-HSA-69601);  (R-HSA-75815);  (R-HSA-8852276);  (R-HSA-8854050);  (R-HSA-8939236);  (R-HSA-8939902);  (R-HSA-8941858);  (R-HSA-8948751);  (R-HSA-8951664);  (R-HSA-9010553);  (R-HSA-9020702);  (R-HSA-9604323);  (R-HSA-9755511);  (R-HSA-9762114);  (R-HSA-9766229);  (R-HSA-9824272);  (R-HSA-983168);  (R-HSA-9907900);  (R-HSA-9929356);  (R-HSA-9929491);  (R-HSA-9931269);  (R-HSA-9932298);  (R-HSA-9954709);  (R-HSA-9958825)",
        "pathway_count": 70,
        "publication_count": 1087,
        "publication_id_list": "10023660;10066435;10075690;10092233;10187770;10196136;10205060;10215629;10230406;10321728;10323868;10339564;10375532;10383417;10411507;10421629;10433824;10444327;10470034;10484077;10514424;10514433;10535940;10559216;10559916;10564661;10572046;10581160;10593898;10597293;10665657;10679238;10693759;10698680;10702308;10716940;10733526;10748049;10779524;10797013;10811609;10823831;10827953;10838074;10854325;10878807;10882101;10884341;10911365;10918611;10944113;10966113;10973495;10973499;10975528;10982817;10984056;10995389;11024059;11027307;11035045;11046155;11053425;11057907;11062501;11069780;11081627;11090634;11094434;11125146;11146634;11231585;11237011;11239468;11248027;11259415;11262391;11285280;11292861;11292862;11298456;11325957;11350924;11358837;11358993;11371342;11454738;11460167;11486055;11493923;11504826;11504942;11509732;11520989;11562349;11562789;11566882;11584266;11585840;11598268;11606584;11733065;11739726;11772397;11804587;11812794;11842200;11847229;11884229;11923872;11931757;11960000;11960013;11961546;11970895;12000792;12050670;12061891;12068298;12070128;12070292;12101228;12118249;12123571;12136087;12138125;12186903;12194817;12198130;12234927;12297295;12351678;12353037;12359729;12379217;12379510;12399544;12403779;12426310;12446569;12473183;12473184;12496252;12504025;12504026;12526791;12538644;12538665;12546821;12554650;12600938;12604685;12609982;12615973;12646216;12646235;12660156;12660731;12676583;12676925;12682069;12700136;12724779;12738770;12750368;12759351;12759363;12787671;12788921;12791267;12791687;12808096;12816948;12819195;12820959;12821933;12853446;12860405;12912907;12915405;12917689;12917691;12923053;12963847;1317798;1352877;1356264;1359686;1377674;14514672;14517290;14517306;14528300;14528312;14564014;14585973;14603323;14611647;14625308;14661020;14661924;14672932;14676825;14681206;14684739;14688281;14690597;14695475;14707141;14734113;14757770;14764894;15014503;15029244;15053880;15075292;15084608;15105418;15115751;15122200;15125833;15138260;15140882;15145317;15163793;15175422;15198976;15199159;15224091;15224092;15226418;15247232;15257295;15282312;15292211;15300262;15327769;15327770;15340381;15361859;15367669;15371334;15469821;15469984;15472518;15474027;15537541;15538386;15541657;15571818;15572695;15574592;15577943;15592455;15592474;15601839;15611333;15652483;15652751;15664193;15678106;15678131;15683364;15688063;15694336;1570011;15703179;15735151;15735756;15737063;15749015;15781449;15799966;15831487;15845454;15863492;15899824;15916963;15917222;15917247;15937478;15983046;15987702;16056267;16061793;16115867;16136078;16140942;16155214;16171779;16186825;16209941;16214042;16251969;16252004;16282375;16286508;16301747;16303288;16335952;16341139;16356853;16356855;16356856;16359182;16360641;16371461;16371649;16401342;16413484;16421188;16421275;16446366;16459297;16459298;16478641;16547496;16547521;16551619;16556936;16595681;16611729;16611981;16612002;16647857;16651542;16687519;16705181;16707496;16728642;16732330;16738327;16740475;16753179;16790436;16816140;16818754;16824194;16831874;16849449;16884355;16901786;16901789;16906146;16931761;16943200;16954532;1695717;16962933;16964248;16971392;16973613;16978534;16980583;16990800;17047224;17072321;17081101;17115028;17126548;17132228;17135271;17139257;17141195;17158449;17161475;17182618;17183061;17183367;17187060;17189198;17204608;17218260;17220875;17234884;17254968;17283082;17290220;17318175;17323924;17332328;17363905;17395884;17428801;17434750;17442700;17443180;17468049;17485488;17496917;17497243;17507369;17507410;17510365;17512459;17523162;17540904;17548359;1756723;17636564;17641202;17675297;17693683;17707232;17728103;17728323;17785452;17786208;17855752;17873522;17890055;17894550;17900240;17947239;17948026;17948050;17977821;17979524;17980597;17981138;17997719;18031682;18070982;18093314;18162290;18167338;18172164;18180283;18184961;18206966;18235225;18238777;18248330;18249105;18264092;18273910;18280240;1828071;18281465;18282684;1833184;18337469;18434309;18438411;18455992;18462924;18467330;18480045;18485873;18497258;18497827;18502753;18534984;18541707;18555777;18573886;18593949;18632802;18632848;18635759;18636086;18644862;18662542;18692471;18701449;18711132;18716059;18719096;18720373;18758443;18772140;18775313;18776931;18805092;18826954;18827223;18832070;18851830;18926707;18997792;18997794;19002207;19015242;19028597;19056373;19061640;19066035;19081070;19122653;19125156;19135894;19166925;19188362;19188440;19202061;19208626;19214193;19217269;19250909;19264966;19305393;19317650;19321346;19345329;19346256;19349277;19352404;19359218;19363159;19368795;19371734;19379695;19398555;19424180;19447222;19452197;19473979;19473982;19489725;19490896;19513348;19533801;19549984;19570978;19573811;19592253;19593530;19603532;19617556;19622347;19666503;1968359;19684112;19706539;19729658;19734889;19748355;19759537;19808967;19815541;19815555;19818708;19838211;19851334;19852954;19862647;19874575;19874889;19878745;19896182;19903815;19909372;19910467;19934406;19940261;19955409;1998343;19996169;20014402;20016067;20018861;20028659;20038579;20068231;20096447;20100835;20104595;20154143;20193029;20227366;20228808;20236090;20300203;20348946;20360384;20368735;20378532;20436459;20449947;20452972;20460306;20471946;20487519;20495340;20501646;20501935;20512148;20536836;20538596;20543837;20577264;20583968;20585641;20621639;20643644;20685844;20707881;20734105;20805357;20818436;20844016;20849292;20858899;20887958;20889716;20956384;21081755;21083385;21091114;21177870;21209280;2121370;21220506;21239494;21245377;21252624;21257310;21317288;21329875;21329882;21335549;2135388;21357747;21362556;21372320;21391649;2139180;21447816;21463634;21478859;2147937;21525931;21532586;21571218;21571647;21596315;21652558;21659512;21695114;21734707;21778237;21799911;21801010;2183031;21849505;21863050;21878643;21921029;21931630;21940857;21962518;21966355;21983142;22007132;22012064;22029577;22036506;22047557;22069318;22085928;22101459;2210768;22117219;22128162;22142471;22153078;22178883;22216260;22265677;22267219;22279049;22286099;22306028;22306998;22318583;2236053;22391301;22422618;22424782;22427670;22440753;22466964;22505454;22508986;22537386;22544926;2261476;22718757;22751498;22751928;22761442;22789539;22798961;22800433;22802525;22869377;22872865;22885700;22897851;22898188;22909820;22959436;22964642;22982193;23063411;23069990;23112049;23140627;23144924;23159851;23186163;23201271;23217742;23236459;23246432;23256519;23274085;23301498;23332756;23333304;23333871;23395819;23401859;23403054;23419514;23443682;23452856;23453757;23481700;23486064;23535009;23535662;23535663;23563313;23579495;23583660;23603117;23613522;23650620;23661552;23685075;23719536;23725801;23746841;23824326;23825189;23851460;23867461;23878308;23912815;23943595;23955340;23986495;24011591;24019521;2405250;24056413;24072710;24074955;24076655;24260525;24270891;24275569;24298019;24302888;24309468;24366543;24366607;24367090;24397554;24493797;24582806;24585635;24636985;24685677;24714562;24715725;2475911;24784881;24793695;24793696;24814062;24845016;24854174;24896179;24925320;25040165;25043025;25083866;25132172;25133187;25152365;25197364;25231993;25242263;25253721;25260729;25305019;2530630;25314029;25339975;25349211;25355947;25394790;25418920;25531226;25547115;25576301;25578727;25578875;25584290;25645385;25654763;2570070;2570460;25733683;25740432;25793262;25810538;25892735;25921531;26091038;26117325;26154972;26183061;26208431;26222030;26280083;26280536;26344709;26375851;26443277;26460955;26583321;26632597;26728094;26768311;26778333;26906416;26929215;26942676;26992070;27030794;27137657;27222660;27249176;27342858;27397612;27428775;27466718;27565346;27572267;27600516;27846572;27862975;27893789;27920218;28115426;28132103;28178531;28218747;28228285;28263418;28317937;28380357;28442575;28446606;28510447;28514659;28598414;28832583;28834231;28904123;2898143;29055231;29153394;29233872;29242379;29314611;29351928;29356040;29393594;29437277;29450944;2946959;29493099;29508533;29526543;29557506;29632046;29632312;29632711;29717933;29769354;29786170;29789417;30118680;30192525;30244831;30315122;30334692;30334693;30379171;30410026;30429286;30524438;30610225;30728908;30779550;30833945;31011209;31020640;31154438;31217245;31222486;3129195;31530632;31546975;31611695;31679946;31844290;31848261;31937595;31998317;32005965;32157095;32161166;32210007;32265295;32284348;32293500;32350084;32357974;32387766;32488085;32502341;32640524;32672401;32897882;32938616;32981041;32983136;33009401;33043033;33123756;33141586;33298915;33392160;33406423;33444648;33537174;33592498;33691108;33717175;33791708;33859744;33909987;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34215617;34229054;34315872;34357683;34405274;34509645;3457471;3472246;34932366;35008409;35051231;35154160;35318648;35385574;35580925;36010968;36198437;36215666;36241641;36284347;37676773;37844756;37938771;37975230;38017133;38061486;38665916;40596516;40914422;7479848;7479976;7499357;7510216;7512451;7523390;7529176;7544915;7553863;7553864;7559638;7575604;7578059;7612269;7628694;7639698;7799959;7809113;7811704;7831327;7862124;7865904;7885476;7957109;7985023;8107774;8140422;8234276;8327496;8332913;8387275;8521496;8550590;8563751;8599092;8601309;8626374;8662591;8662795;8670417;8689684;8692836;8702708;8706131;8824192;8837778;8896571;8921937;8972730;9122164;9135156;9136925;9219684;9230313;9247583;9252186;9302992;9315679;9346238;9346484;9362451;9371760;9372967;9374539;9380723;9430229;9482734;9520446;9528852;9535855;9593755;9601642;9628874;9635433;9652413;9660940;9668046;9674432;9687533;9721103;9742107;9747882;9790970;9816258;9831708;9844631;9859996;9874371;9887101;9891082;9892021;9914500;9990852;9990853",
        "class_list": "",
        "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:9374539, PubMed:1317798). The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex (PubMed:22909820). Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation (PubMed:22909820). Also involved in homologous recombination repair by promoting RAD51 loading (PubMed:22909820). Regulates macroautophagy by ensuring Golgi-to-ER retrograde transport through its deubiquitinating activity on K63-linked ubiquitin chains. This activity prevents the retention of essential autophagy proteins at the Golgi, enabling their trafficking to autophagosome formation sites and supporting Golgi-ER membrane recycling critical for effective autophagy (PubMed:32210007)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; POH1 facilitates pancreatic carcinogenesis through MYC-driven acinar-to-ductal metaplasia and is a potential therapeutic target., [RefSeq, PubMed]; POH1 induces Smad3 deubiquitination and promotes lung cancer metastasis., [RefSeq, PubMed]; PSMD14 stabilizes estrogen signaling and facilitates breast cancer progression via deubiquitinating ERalpha., [RefSeq, PubMed]; Regulation of Drp1 and enhancement of mitochondrial fission by the deubiquitinating enzyme PSMD14 facilitates the proliferation of bladder cancer cells., [RefSeq, PubMed]; This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KNW2;O00176",
        "ec_number_list": "3.4.19.12;3.6.4.13;2.3.2.24;2.3.2.23;2.7.1.35;2.7.11.1;3.1.-.-;1.1.1.42;2.3.2.27;2.4.2.-;2.4.2.30;2.4.2.1;3.4.21.46;1.16.3.1;1.11.1.6;4.1.2.13;2.7.11.22;2.7.11.23;2.4.1.1;5.3.1.9;5.1.3.-;3.4.23.5;3.4.22.52;2.4.2.7;3.4.22.1;3.6.4.10;3.2.1.31;2.5.1.18;2.7.10.2;1.13.11.-;1.13.11.34;3.3.2.6;3.4.11.4;1.11.1.7;4.1.1.17;1.1.1.205;4.2.99.18;5.6.2.4;5.6.1.6;3.6.5.-;4.2.1.24;3.4.19.1;5.3.2.1;5.3.3.12;2.7.1.40;3.4.24.35;3.1.6.14;3.1.6.12;3.2.1.23;2.7.1.11;5.4.2.11;5.4.2.4;2.7.4.6;2.7.13.3;3.4.22.27;3.4.25.1;2.7.11.24;3.1.3.48;3.5.4.5;5.4.2.2;2.4.1.186;2.7.11.26;3.6.1.-;2.7.1.1;2.7.1.-;2.7.11.21;2.3.3.8;3.6.4.6;3.1.3.67;3.1.3.-;3.1.3.16;3.6.5.2;2.3.2.32;5.2.1.8;3.1.1.47;3.1.1.-;3.5.4.6;1.11.1.24;2.7.11.39;3.5.1.23;3.5.1.-;3.5.1.109;2.3.2.5;2.3.2.26;3.6.1.6;5.4.2.7;2.7.11.25;1.14.11.29;1.14.11.-;3.4.18.1;4.1.2.4",
        "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding;GO:0061133 endopeptidase activator activity;GO:0070628 proteasome binding;GO:0004843 cysteine-type deubiquitinase activity",
        "go_cellular_component": "GO:0031597 cytosolic proteasome complex;GO:0022624 proteasome accessory complex;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0071357 cellular response to type I interferon;GO:0006979 response to oxidative stress;GO:0016579 protein deubiquitination;GO:0045471 response to ethanol;GO:0070536 protein K63-linked deubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 109.1,
        "record_id": "O00487-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q00872-1",
        "uniprot_id": "MYPC1_HUMAN",
        "mass": 128294.0,
        "length": 1141,
        "protein_name": "Myosin-binding protein C, slow-type",
        "gene_name": "MYBPC1",
        "organism": "Human",
        "refseq_name": "myosin-binding protein C, slow-type isoform 7",
        "refseq_ac": "NP_001241649",
        "gene_names_uniprotkb": "MYBPC1; MYBPCS",
        "gene_names_refseq": "CMYO16; CMYP16; LCCS4; MYBPC1; MYBPCC; MYBPCS; MYOTREM; ssMyBP-C",
        "protein_names_uniprotkb": "Myosin-binding protein C, slow-type; C-protein, skeletal muscle slow isoform; Slow MyBP-C",
        "protein_names_refseq": "myosin binding protein C, slow type; myosin-binding protein C, slow-type isoform 7; skeletal muscle C-protein; slow MyBP-C; slow skeletal-type muscle myosin-binding-protein C",
        "tax_id": 9606,
        "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); lethal congenital contracture syndrome 4 (Disease Ontology:DOID:0060654); congenital myopathy (Disease Ontology:DOID:0081337); congenital myopathy 16 (Disease Ontology:DOID:0081348); distal arthrogryposis type 1B (Disease Ontology:DOID:0111598); congenital heart disease (Disease Ontology:DOID:1682)",
        "pathway": " (hsa:4604);  (R-HSA-390522)",
        "pathway_count": 2,
        "publication_count": 22,
        "publication_id_list": "10747208;11237011;1429890;16501887;20045868;20068231;22610851;24715725;26661508;30379171;31025394;31154438;31264822;32387766;33592498;35051231;35580925;36539363;37217939;37392669;38185014;8375400",
        "class_list": "",
        "function": "A Case Series of Patients With MYBPC1 Gene Variants Featuring Undulating Tongue Movements as Myogenic Tremor., [RefSeq, PubMed]; Congenital tremor and myopathy secondary to novel MYBPC1 variant., [RefSeq, PubMed]; Data substantiate that damaging variants in MYBPC1 are associated with a new form of an early-onset myopathy with tremor, which is a defining and consistent characteristic in all affected individuals, with no contractures. Recognition of this expanded myopathic phenotype can enable identification of individuals with MYBPC1 variants without arthrogryposis., [RefSeq, PubMed]; MYBPC1 is a key regulator for laryngeal carcinoma formation., [RefSeq, PubMed]; These findings reveal that the MYBPC1 is a novel gene responsible for DA1, though the mechanism of disease may differ from how some cardiac MYBPC3 mutations cause hypertrophic cardiomyopathy., [RefSeq, PubMed]; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin. In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; This gene encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DKR5;B7Z8G8;B7ZL02;B7ZL09;B7ZL10;E7ESM5;E7EWS6;G3XAE8;Q15497;Q17RR7;Q569K7;Q86T48;Q86TC8;Q8N3L2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0017022 myosin binding;GO:0008307 structural constituent of muscle;GO:0031432 titin binding;GO:0005198 structural molecule activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0032982 myosin filament;GO:0031430 M band;GO:0030016 myofibril",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0045214 sarcomere organization",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "Q00872-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P82979-1",
        "uniprot_id": "SARNP_HUMAN",
        "mass": 23671.0,
        "length": 210,
        "protein_name": "SAP domain-containing ribonucleoprotein",
        "gene_name": "SARNP",
        "organism": "Human",
        "refseq_name": "SAP domain-containing ribonucleoprotein",
        "refseq_ac": "NP_149073",
        "gene_names_uniprotkb": "SARNP; HCC1; HSPC316",
        "gene_names_refseq": "CIP29; HCC1; HSPC316; SARNP; THO1",
        "protein_names_uniprotkb": "SAP domain-containing ribonucleoprotein; Cytokine-induced protein of 29 kDa; Nuclear protein Hcc-1; Proliferation-associated cytokine-inducible protein CIP29",
        "protein_names_refseq": "SAP domain-containing ribonucleoprotein; cytokine induced protein 29 kDa; cytokine-induced protein of 29 kDa; hepatocellular carcinoma 1; nuclear protein Hcc-1; proliferation associated cytokine-inducible protein CIP29",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84324);  (R-HSA-159236);  (R-HSA-72187)",
        "pathway_count": 3,
        "publication_count": 124,
        "publication_id_list": "10.1101/2023.09.13.557529;10228171;10323864;10489353;10668806;11073998;11237011;11256625;11259411;11259602;11356193;11579093;11739738;11756420;11922608;11979277;12093754;12871933;15338056;15998806;16314397;17000901;17190602;17196963;17984224;18212344;18364396;18411249;18423201;18669648;18957205;19836239;20068231;20129943;20573985;20844015;21947206;22207203;22223895;22893130;22928037;23222130;23299939;23481700;23826332;24190977;24244187;24366607;24714562;25418920;25502872;25576301;25662211;25836925;25892735;26154972;26728094;26811146;26929215;26992070;27397612;27600516;27862975;27920218;28352266;28649982;28657654;28832583;28834231;28904123;29237092;29242379;29393594;29508533;29557506;29632046;29632711;29786170;29789417;30059200;30315122;30410026;30429286;30620550;31154438;31217245;31373491;31492838;31611695;31844290;32157095;32265295;32350084;32387766;32502341;32938616;32983136;33214551;33298915;33691108;33968037;34019948;34087483;34211107;34405274;34846842;35051231;35132862;35251023;35289036;35513511;35580925;36241641;36284347;37578863;38665916;39302247;39531497;39534244;40136647;40307207;40596516;9618489;9660949",
        "class_list": "",
        "function": "Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; CIP29 appears to be a new cytokine regulated protein involved in normal and cancer cell proliferation., [RefSeq, PubMed]; CIP29 physically and functionally associates with DDX39, suggesting their cooperation in the RNA metabolism., [RefSeq, PubMed]; Hcc-1 plays a role in growth regulation and nucleic acids metabolism., [RefSeq, PubMed]; Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly., [RefSeq, PubMed]; This gene encodes a protein that is upregulated in response to various cytokines. The encoded protein may play a role in cell cycle progression. A translocation between this gene and the myeloid/lymphoid leukemia gene, resulting in expression of a chimeric protein, has been associated with acute myelomonocytic leukemia. Pseudogenes exist on chromosomes 7 and 8. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 9,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 9,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 9,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K393;Q9P066",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0000346 transcription export complex",
        "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006351 DNA-templated transcription;GO:0006406 mRNA export from nucleus;GO:0006417 regulation of translation;GO:0051028 mRNA transport",
        "synthesized_glycan_count": 0,
        "hit_score": 13.7,
        "record_id": "P82979-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O77932-1",
        "uniprot_id": "DXO_HUMAN",
        "mass": 44929.0,
        "length": 396,
        "protein_name": "Decapping and exoribonuclease protein",
        "gene_name": "DXO",
        "organism": "Human",
        "refseq_name": "decapping and exoribonuclease protein isoform 2",
        "refseq_ac": "NP_005501",
        "gene_names_uniprotkb": "DXO; DOM3L; DOM3Z; NG6",
        "gene_names_refseq": "DOM3L; DOM3Z; DXO; NG6",
        "protein_names_uniprotkb": "Decapping and exoribonuclease protein; 3.1.13.-; 3.6.1.-; 5'-3' exoribonuclease DXO; DXO; DeNADding enzyme DXO; Dom-3 homolog Z; NAD-capped RNA hydrolase DXO",
        "protein_names_refseq": "5'-3' exoribonuclease DXO; NAD-capped RNA hydrolase DXO; deNADding enzyme DXO; decapping and exoribonuclease protein isoform 2; decapping and exoribonuclease protein; protein Dom3Z",
        "tax_id": 9606,
        "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:1797);  (R-HSA-9930044)",
        "pathway_count": 2,
        "publication_count": 52,
        "publication_id_list": "10686478;11237011;14656967;17174896;17412707;20112406;21705430;21750099;21855801;23481700;25418920;25578728;25645385;25892735;26811146;26929215;26992070;27434818;27846572;27871484;27920218;28063628;28218747;28283058;28860189;28904123;29242379;29298432;29393594;29437277;29557506;29601584;29632046;29672716;29769354;29786170;29906447;31101919;31844290;31950173;32265295;32374864;32387766;32488085;32938616;33392160;33767452;33913806;33936100;33968037;37875486;9799600",
        "class_list": "",
        "function": "DOM3Z limits both miR-122-dependent and miR-122-independent Hepatitis C RNA accumulation., [RefSeq, PubMed]; Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Study showed that DXO is a multifunctional enzyme that possesses both decapping and 5'-3' exoribonuclease activities toward non-2'-O-methylated RNA transcripts. DXO is directly involved in the mRNA quality control mechanism by degrading mRNAs with abnormal cap structures. Erratum:[PLoS One. 2018 Aug 9;13(8):e0202308. doi: 10.1371/journal.pone.0202308. PMID: 30092053] Publication Status: Online-Only, [RefSeq, PubMed]; This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2CER3;B0UZ80;O15004;O78127;O78128;Q5ST60;Q6IPZ2;Q9NPK4",
        "ec_number_list": "3.1.13.-;3.6.1.-",
        "go_molecular_function": "GO:0034353 mRNA 5'-diphosphatase activity;GO:0000287 magnesium ion binding;GO:0003729 mRNA binding;GO:0000166 nucleotide binding;GO:0008409 5'-3' exonuclease activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0050779 RNA destabilization;GO:0071028 nuclear mRNA surveillance;GO:0006402 mRNA catabolic process;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0110155 NAD-cap decapping",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "O77932-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6IAN0-1",
        "uniprot_id": "PEXRP_HUMAN",
        "mass": 35119.0,
        "length": 325,
        "protein_name": "Peroxisomal reductase activating PPAR-gamma",
        "gene_name": "DHRS7B",
        "organism": "Human",
        "refseq_name": "peroxisomal reductase activating PPAR-gamma isoform 1",
        "refseq_ac": "NP_056325",
        "gene_names_uniprotkb": "DHRS7B; CGI-93; PRO238; SDR32C1",
        "gene_names_refseq": "CGI-93; DHRS7B; PexRAP; SDR32C1",
        "protein_names_uniprotkb": "Peroxisomal reductase activating PPAR-gamma; 1.1.1.101; Dehydrogenase/reductase SDR family member 7B; PexRAP; Protein SDR32C1; Short-chain dehydrogenase/reductase family 32C member 1",
        "protein_names_refseq": "dehydrogenase/reductase (SDR family) member 7B; peroxisomal reductase activating PPAR-gamma isoform 1; peroxisomal reductase activating PPAR-gamma; short-chain dehydrogenase/reductase family 32C member 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:25979);  (R-HSA-75896)",
        "pathway_count": 2,
        "publication_count": 30,
        "publication_id_list": "10215861;10415121;10692424;11230166;11237011;11237722;12975309;19027726;22863804;2335525;26154972;26992070;28063628;28228285;28904123;29557506;29632046;31611695;31844290;32350084;32387766;32502341;32938616;33912179;33968037;35051231;35580925;37938771;8186247;9536089",
        "class_list": "",
        "function": "Reductase required for adipogenesis and activation of PPARG nuclear receptor. Can convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively, synthesizing ether-linked phospholipids that act as agonists for PPARG. Also regulates adipogenesis by preventing adipocyte browning: following import into the nucleus, interacts with PRDM16, inhibiting the interaction between PRDM16 and PPARG and preventing differentiation of brown adipocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5MEF4;Q6UX59;Q9BTF9;Q9UFM6;Q9Y3A1",
        "ec_number_list": "1.1.1.101",
        "go_molecular_function": "GO:0000140 acylglycerone-phosphate reductase (NADP+) activity;GO:0016491 oxidoreductase activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005778 peroxisomal membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0008611 ether lipid biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "Q6IAN0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P56555-1",
        "uniprot_id": "DSCR4_HUMAN",
        "mass": 12955.0,
        "length": 118,
        "protein_name": "Down syndrome critical region protein 4",
        "gene_name": "DSCR4",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DSCR4; DCRB; DSCRB",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Down syndrome critical region protein 4; Down syndrome critical region protein B",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "Parkinson's disease (Disease Ontology:DOID:14330)",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "9455479",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4VB31",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "P56555-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TD19-1",
        "uniprot_id": "NEK9_HUMAN",
        "mass": 107168.0,
        "length": 979,
        "protein_name": "Serine/threonine-protein kinase Nek9",
        "gene_name": "NEK9",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein kinase Nek9 isoform 1",
        "refseq_ac": "NP_001316166",
        "gene_names_uniprotkb": "NEK9; KIAA1995; NEK8; NERCC",
        "gene_names_refseq": "APUG; LCCS10; NC; NEK9; NERCC1; NERCC",
        "protein_names_uniprotkb": "Serine/threonine-protein kinase Nek9; 2.7.11.38; Nek8; Nercc1 kinase; Never in mitosis A-related kinase 9; NimA-related kinase 8; NimA-related protein kinase 9",
        "protein_names_refseq": "NIMA (never in mitosis gene a)- related kinase 9; nercc1 kinase; nimA-related protein kinase 9; serine/threonine-protein kinase Nek9 isoform 1; serine/threonine-protein kinase Nek9",
        "tax_id": 9606,
        "disease": "lethal congenital contracture syndrome (Disease Ontology:DOID:0060558); lethal congenital contracture syndrome 10 (Disease Ontology:DOID:0061266); amyotrophic lateral sclerosis type 24 (Disease Ontology:DOID:0081378); arthrogryposis, Perthes disease, and upward gaze palsy (MONDO:MONDO:0013660); nevus comedonicus syndrome (MONDO:MONDO:0014873)",
        "pathway": " (hsa:91754);  (R-HSA-2980767);  (R-HSA-3301854);  (R-HSA-9648025)",
        "pathway_count": 4,
        "publication_count": 122,
        "publication_id_list": "11237011;11864968;12056414;12101123;12589057;12679384;12840024;12852857;14660563;16079175;16890222;16964243;17081983;17192257;17196341;17344846;17698605;18669648;18691976;18767875;19001501;19369195;19413330;19651622;19690332;19941817;20068231;20166139;21335236;21454704;21642957;22223895;23186163;23301498;23481700;23482567;24275569;24366607;24714562;24715725;25418920;25576301;25740311;25789526;26154972;26522158;26633546;26728094;26811146;26908619;26929215;26992070;27153399;27543614;27600516;27846572;27920218;28121444;28218747;28228285;28467828;28657654;28832583;28834231;28855257;28904123;29242379;29314611;29317506;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30410026;30429286;30484775;30524438;31154438;31217245;31409757;31844290;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34171305;34185709;34229054;34357683;34932366;35051231;35154160;35318648;35561310;35580925;35935324;36215666;36241641;36266340;36284347;37938771;38665916;40307207",
        "class_list": "",
        "function": "Activated in mitosis, and activates nek6 and nek7 kinase., [RefSeq, PubMed]; Binds the Ran GTPase and regulates mitotic progression, [RefSeq, PubMed]; NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart. Publication Status: Online-Only, [RefSeq, PubMed]; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Study on the Expression of lncRNA ATB and Nek9 in Breast Cancer Patients Based on Q-PCR Technology and Its Relationship with the Disease. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 47,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q52LK6;Q8NCN0;Q8TCY4;Q9UPI4;Q9Y6S4;Q9Y6S5;Q9Y6S6",
        "ec_number_list": "3.6.5.-;2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.3.2.-;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 12.5,
        "record_id": "Q8TD19-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y5J3-1",
        "uniprot_id": "HEY1_HUMAN",
        "mass": 32613.0,
        "length": 304,
        "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 1",
        "gene_name": "HEY1",
        "organism": "Human",
        "refseq_name": "hairy/enhancer-of-split related with YRPW motif protein 1 isoform b",
        "refseq_ac": "NP_001035798",
        "gene_names_uniprotkb": "HEY1; BHLHB31; CHF2; HERP2; HESR1; HRT1",
        "gene_names_refseq": "BHLHb31; CHF2; HERP2; HESR1; HEY1; HRT-1; NERP2; OAF1; hHRT1",
        "protein_names_uniprotkb": "Hairy/enhancer-of-split related with YRPW motif protein 1; CHF-2; Cardiovascular helix-loop-helix factor 2; Class B basic helix-loop-helix protein 31; HES-related repressor protein 1; HESR-1; HRT-1; Hairy and enhancer of split-related protein 1; Hairy-related transcription factor 1; bHLHb31; hHRT1",
        "protein_names_refseq": "HES-related repressor protein 1; HES-related repressor protein 2; basic helix-loop-helix protein OAF1; cardiovascular helix-loop-helix factor 2; class B basic helix-loop-helix protein 31; hairy and enhancer of split-related protein 1; hairy-related transcription factor 1; hairy/enhancer-of-split related with YRPW motif 1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform b; hairy/enhancer-of-split related with YRPW motif protein 1",
        "tax_id": 9606,
        "disease": "hemangiopericytoma (Disease Ontology:DOID:264); hemangioblastoma (Disease Ontology:DOID:5241); diabetes mellitus (Disease Ontology:DOID:9351)",
        "pathway": " (hsa:23462);  (R-HSA-2122947);  (R-HSA-2644606);  (R-HSA-2894862);  (R-HSA-8940973);  (R-HSA-9013508);  (R-HSA-9013695);  (R-HSA-9733709)",
        "pathway_count": 8,
        "publication_count": 131,
        "publication_id_list": "10206645;10403790;10415358;10692439;10713164;10860664;10879540;10882063;10964718;11006133;11044625;11095750;11106645;11237011;11461910;11545733;11585921;11740940;11866432;12050117;12209127;12231506;12354787;12386158;12391150;12391164;12529404;12530964;14672936;14765127;14980219;15095414;15107403;15485867;15531924;15546612;15574878;15760269;15824097;15829515;16025100;16093323;16099986;16256737;16530044;16738328;16751105;17003037;17114293;17401372;17646408;17646409;18043734;18077452;18094723;18239137;18296446;18374649;18477452;18824583;18824585;18974129;19151708;19389811;19413330;19479054;19524514;19726682;19801668;20686481;20804727;20877012;20972443;21173110;22396495;24715725;25187301;25417103;25865393;25892735;25985737;26068074;26387946;26783251;26801977;26967290;26992070;27129302;27749937;27797343;27841855;28832583;28834231;28904123;29146722;29242379;29557506;29636455;29769354;31154438;31217245;31844290;31848261;32157095;32161166;32488085;33054971;34002044;34171305;34932366;35051231;35580925;36396748;37217939;37541260;38166414;7566092;7588063;7891679;8001118;8649374;8687460;9182762;9244301;9315665;9462510;9604939;9620803;9651681;9694793;9819428",
        "class_list": "",
        "function": "HEY1-mediated cisplatin resistance in lung adenocarcinoma via epithelial-mesenchymal transition. Publication Status: Online-Only, [RefSeq, PubMed]; LncRNA MAGI2-AS3 inhibits tumor progression and angiogenesis by regulating ACY1 via interacting with transcription factor HEY1 in clear cell renal cell carcinoma., [RefSeq, PubMed]; SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis., [RefSeq, PubMed]; This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R883;Q5TZS3;Q8NAM2;Q9NYP4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0072359 circulatory system development;GO:0003208 cardiac ventricle morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 13.5,
        "record_id": "Q9Y5J3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14204-1",
        "uniprot_id": "DYHC1_HUMAN",
        "mass": 532408.0,
        "length": 4646,
        "protein_name": "Cytoplasmic dynein 1 heavy chain 1",
        "gene_name": "DYNC1H1",
        "organism": "Human",
        "refseq_name": "cytoplasmic dynein 1 heavy chain 1",
        "refseq_ac": "NP_001367",
        "gene_names_uniprotkb": "DYNC1H1; DHC1; DNCH1; DNCL; DNECL; DYHC; KIAA0325",
        "gene_names_refseq": "CDCBM13; CMT2O; DHC1a; DHC1; DNCH1; DNCL; DNECL; DYHC; DYNC1H1; Dnchc1; HL-3; SMALED1; p22",
        "protein_names_uniprotkb": "Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein heavy chain 1; Dynein heavy chain, cytosolic",
        "protein_names_refseq": "cytoplasmic dynein 1 heavy chain 1; dynein heavy chain, cytosolic; dynein, cytoplasmic, heavy polypeptide 1",
        "tax_id": 9606,
        "disease": "lissencephaly (Disease Ontology:DOID:0050453); congenital muscular dystrophy (Disease Ontology:DOID:0050557); complex cortical dysplasia with other brain malformations 13 (Disease Ontology:DOID:0061144); autosomal dominant intellectual developmental disorder 13 (Disease Ontology:DOID:0070043); spinal muscular atrophy with lower extremity predominant (Disease Ontology:DOID:0070348); spinal muscular atrophy with lower extremity predominant 1 (Disease Ontology:DOID:0070351); Charcot-Marie-Tooth disease axonal type 2O (Disease Ontology:DOID:0110175); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); neurodegenerative disease (Disease Ontology:DOID:1289); epilepsy (Disease Ontology:DOID:1826); nervous system disease (Disease Ontology:DOID:863); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:1778);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-2132295);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-2565942);  (R-HSA-3371497);  (R-HSA-380259);  (R-HSA-380270);  (R-HSA-380284);  (R-HSA-380320);  (R-HSA-5620912);  (R-HSA-5663220);  (R-HSA-6798695);  (R-HSA-6807878);  (R-HSA-6811436);  (R-HSA-68877);  (R-HSA-8854518);  (R-HSA-9609690);  (R-HSA-9646399);  (R-HSA-9648025)",
        "pathway_count": 22,
        "publication_count": 576,
        "publication_id_list": "10036229;10052452;10064083;10072072;10089880;10318838;10359595;10411507;10445031;10480952;10491388;10540230;10559959;10559986;10562278;10593899;10600384;10631941;10631952;10639150;10678165;10679020;10747884;10748235;10761932;10809954;10903204;10921873;10958683;11035033;11076968;11080672;11081627;11172815;11181178;11237011;11285137;11306556;11371342;11461920;11483508;11509732;11529500;11535616;11589254;11684289;11689559;11701661;11703931;11726511;11748249;11751894;11790530;11804586;11813165;11853874;11956313;12006501;12024216;12047556;12070132;12078484;12194817;12198549;12207013;12221128;12364337;12388752;12401177;12429848;12432908;12447383;12577064;12634853;12679384;12732141;12742663;12748383;12781197;12805219;12852856;12852857;12857923;12925777;13486053;13678582;14580337;14654841;14654843;14675537;14730319;14731593;14742712;1493716;15006353;15037235;15085137;15159550;15339662;15381148;15483056;15498487;15507212;15591061;15616190;15632110;15705883;15723797;15728195;15737063;15749704;15813748;15864301;15866170;15878873;15911768;15914536;15944396;16030262;16140760;16181339;16207721;16242130;16292343;1631136;16314391;16357211;16403413;16408927;16439214;16462731;16541025;16618111;16622419;16622420;16633337;16682347;16723730;1680566;16824007;16890155;16890222;16912714;16926190;16940185;16943183;17030981;17081983;17112726;17113138;17129783;17142755;17196341;17198702;17253781;17274799;17283181;17322306;17360540;1737036;17429068;17451557;17488286;17574030;17591767;17646400;17719545;17760859;17785525;17804755;17827179;17846173;17927562;17956946;18001770;18037885;18046453;18086915;18097444;18182008;18203656;18215318;18243712;18254226;18283113;18292509;18378770;18452278;18477460;18491316;18521620;18524849;18535146;18566290;18615013;18635947;18641641;18664496;18669648;18691976;18694559;18716626;18801063;18809720;18923426;1898986;19004860;19015319;19081074;19109418;19164740;19296914;19350017;19359544;19415658;1956401;19564404;1957170;19608861;19631211;19635840;19651622;19682613;19696148;19753100;19758564;19815554;19940019;19965387;20006655;20030946;20038533;20068231;20072699;20101212;20112406;20230748;20308558;20357002;20399632;20420828;20427317;20558667;20591975;20637885;21076407;21111234;21116285;21148482;21158691;21173190;21183720;2121367;21219331;21273506;21347367;21376746;21397845;21422230;21441454;21548880;21565611;21576392;21620453;21689688;21690215;21700222;21725307;21792235;21796517;21820100;21844168;21868368;21878504;2190094;21987589;22011577;22013193;22094269;22094460;22094468;22130221;22174689;22179047;22223895;22266222;22275430;22304919;22318716;22365832;22368300;22433123;22433857;22459677;22562055;22608513;22641346;22645359;22653444;22790947;22791416;22847149;22869377;22885700;23033978;23141531;23141541;23186163;23222643;23253480;23301498;23333653;23348840;23400999;23481700;23515720;23530209;23603762;23650620;23747070;23769972;23783758;23789104;23801653;23839779;2391366;23921553;24012426;24053599;24089205;24119662;24200693;24231678;24307404;24366607;24397554;24469809;24694367;24714562;24715725;24806965;24891604;24914801;24982133;25047611;25233431;25313408;25418920;25436559;25453831;25484024;25492864;25512093;25532896;25576301;25645385;25740311;25789526;25810538;25880248;25892735;26073023;26154972;26203193;26313416;26374642;26375851;26572645;26728094;26811146;26846447;26929215;26992070;27397612;27452731;27462074;27462449;27501258;27600516;27663436;27726376;27846572;27862975;27920218;28063628;28083797;28193117;28218747;28228285;28301631;28415052;28514659;28649982;28755533;28832583;28834231;28855257;28860189;28904123;28919297;29237092;29242379;29331515;29351928;29393594;29420470;29437277;29493099;29508533;29557506;29605689;29632046;29632711;29769354;29786170;29789417;30197098;30315122;30360396;30379171;30410026;30429286;30484775;30524438;30761409;30779550;30833945;31092558;31092671;31110491;31141847;31154438;31217245;31222486;31409757;31530632;31731497;31826031;31844290;31848261;31998317;32016915;32119511;32157095;32161166;32265295;32320027;32350084;32357974;32387766;32448030;32488085;32502341;32544881;32897882;32938616;32982970;32983136;33043033;33141586;33214551;33298915;33392160;33402344;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34229054;34260926;34357683;34405274;34509645;34561969;34725712;34932366;35051231;35138101;35154160;35251023;35318648;35561310;35580925;36010968;36071160;36215666;36241641;36284347;36581221;37217939;37903666;37938771;38253038;38665916;38806879;40596516;40914422;6645495;6891012;7481823;7592972;7650016;7667286;7691276;7769006;7790358;8001155;8046351;8128252;8132710;8134367;8145819;8148318;8157723;8221884;8227145;8253837;8282004;8313912;8397411;8415765;8505331;8560673;8620540;8636227;8642258;8666668;8687433;8692836;8838651;8849454;8909537;8939989;8947036;8991093;9030515;9050864;9075930;9114004;9150144;9177194;9202021;9244307;9288971;9311912;9312039;9323141;9380700;9382863;9405360;9464360;9464361;9490716;9497313;9539769;9545226;9606180;9649308;9649503;9667968;9671725;9671731;9733780;9751720;9864362;9892021;9990005",
        "class_list": "",
        "function": "Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; DYNC1H1 variants associated with infant-onset epilepsy without neurodevelopmental disorders., [RefSeq, PubMed]; Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]., [RefSeq]; Multidisciplinary approach on divergent outcomes in spinal muscular atrophies: comparing DYNC1H1 and SMN1 gene mutations., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 28,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 84,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 13,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0I1R0;Q6DKQ7;Q8WU28;Q92814;Q9Y4G5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005938 cell cortex",
        "go_biological_process": "GO:0051293 establishment of spindle localization;GO:0090235 regulation of metaphase plate congression;GO:1905832 positive regulation of spindle assembly;GO:0008090 retrograde axonal transport;GO:0051301 cell division",
        "synthesized_glycan_count": 0,
        "hit_score": 58.6,
        "record_id": "Q14204-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13144-1",
        "uniprot_id": "EI2BE_HUMAN",
        "mass": 80380.0,
        "length": 721,
        "protein_name": "Translation initiation factor eIF2B subunit epsilon",
        "gene_name": "EIF2B5",
        "organism": "Human",
        "refseq_name": "translation initiation factor eIF2B subunit epsilon",
        "refseq_ac": "NP_003898",
        "gene_names_uniprotkb": "EIF2B5; EIF2BE",
        "gene_names_refseq": "CACH; CLE; EIF-2B; EIF2B5; EIF2Bepsilon; LVWM; VWM5",
        "protein_names_uniprotkb": "Translation initiation factor eIF2B subunit epsilon; eIF2B GDP-GTP exchange factor subunit epsilon",
        "protein_names_refseq": "eIF-2B GDP-GTP exchange factor subunit epsilon; eIF2B GDP-GTP exchange factor subunit epsilon; eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa; translation initiation factor eIF-2B subunit epsilon; translation initiation factor eIF2B subunit epsilon",
        "tax_id": 9606,
        "disease": "leukoencephalopathy with vanishing white matter (Disease Ontology:DOID:0060868); leukoencephalopathy with vanishing white matter 5 (Disease Ontology:DOID:0070367)",
        "pathway": " (hsa:8893);  (R-HSA-72731)",
        "pathway_count": 2,
        "publication_count": 118,
        "publication_id_list": "11237011;11311121;11500362;11704758;12133000;12325082;12707859;15302935;15776425;17081983;18088087;18452278;18669648;18691976;18701453;18707149;19007248;19158808;19413330;19651622;19664994;19690332;19736320;20068231;20166139;21406692;21484434;22223895;22544926;23186163;23481700;24275569;24714562;24715725;2491852;25418920;25505266;25576301;25645385;25858979;25880248;26154972;26375851;26728094;26811146;26929215;26992070;27023709;27846572;27920218;28063628;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29485866;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30192525;30315122;30410026;30779550;30784271;30833945;31048492;31530632;31844290;31848261;31937595;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33300869;33392160;3356695;33592498;33691108;33717175;33912179;33936100;33968037;34357683;34509645;34561969;34725712;35051231;35318648;35580925;35710311;36010968;36241641;36581221;37674283;38665916;40914422;8397507;8688466;9468292",
        "class_list": "",
        "function": "A novel missense variant in EIF2B5 identified in a consanguineous Iranian family with vanishing white matter disease and a brief review of the literature. Review article, [RefSeq, PubMed]; Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; CircAHNAK upregulates EIF2B5 expression to inhibit the progression of ovarian cancer by modulating the JAK2/STAT3 signaling pathway., [RefSeq, PubMed]; This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009]., [RefSeq]; Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 27,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q541Z1;Q96D04",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005851 eukaryotic translation initiation factor 2B complex",
        "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0002183 cytoplasmic translational initiation;GO:0043065 positive regulation of apoptotic process;GO:0021766 hippocampus development;GO:0042552 myelination",
        "synthesized_glycan_count": 0,
        "hit_score": 12.1,
        "record_id": "Q13144-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15353-1",
        "uniprot_id": "FOXN1_HUMAN",
        "mass": 68925.0,
        "length": 648,
        "protein_name": "Forkhead box protein N1",
        "gene_name": "FOXN1",
        "organism": "Human",
        "refseq_name": "forkhead box protein N1",
        "refseq_ac": "NP_003584",
        "gene_names_uniprotkb": "FOXN1; RONU; WHN",
        "gene_names_refseq": "FKHL20; FOXN1; RONU; TIDAND; TIDTA; TLIND; WHN",
        "protein_names_uniprotkb": "Forkhead box protein N1; Winged-helix transcription factor nude",
        "protein_names_refseq": "Rowett nude; forkhead box protein N1; winged-helix nude; winged-helix transcription factor nude",
        "tax_id": 9606,
        "disease": "T-cell immunodeficiency, congenital alopecia, and nail dystrophy (Disease Ontology:DOID:0060769); DiGeorge syndrome (Disease Ontology:DOID:11198); Nezelof syndrome (Disease Ontology:DOID:2012); nail disease (Disease Ontology:DOID:4123); primary immunodeficiency disease (Disease Ontology:DOID:612); alopecia (Disease Ontology:DOID:987); T-cell lymphopenia, infantile, with or without nail dystrophy, autosomal dominant (MONDO:MONDO:0032928)",
        "pathway": " (hsa:8456)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "10206641;11237011;15180707;20978268;21507891;23874334;24432845;25173801;28636882;29557506;29769354;31447097;31566583;32938616;33464451;35051231;35527675;36631020;37419334;9321431",
        "class_list": "",
        "function": "Comprehensive phenotypic analysis of diverse FOXN1 variants., [RefSeq, PubMed]; Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations., [RefSeq, PubMed]; Expression of BMP4 and FOXN1 in orthokeratinized odontogenic cyst compared to odontogenic keratocyst suggests an epidermal phenotype., [RefSeq, PubMed]; Mutation of the FOXN1 gene is associated with congenital severe combined immunodeficiency associated with alopecia, [RefSeq, PubMed]; Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny (PubMed:21507891)., [UniProtKB, PubMed, UniProtKB]; [Effects of FoxN1, p63 and AIRE on the process of age-related thymus involution: An update]. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 7,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R9Q7;O15352",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0002360 T cell lineage commitment;GO:0030858 positive regulation of epithelial cell differentiation;GO:1902232 regulation of positive thymic T cell selection;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "O15353-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IWF2-1",
        "uniprot_id": "FXRD2_HUMAN",
        "mass": 77791.0,
        "length": 684,
        "protein_name": "FAD-dependent oxidoreductase domain-containing protein 2",
        "gene_name": "FOXRED2",
        "organism": "Human",
        "refseq_name": "FAD-dependent oxidoreductase domain-containing protein 2 isoform 1 precursor",
        "refseq_ac": "NP_001095841",
        "gene_names_uniprotkb": "FOXRED2; ERFAD",
        "gene_names_refseq": "ERFAD; FOXRED2",
        "protein_names_uniprotkb": "FAD-dependent oxidoreductase domain-containing protein 2; Endoplasmic reticulum flavoprotein associated with degradation",
        "protein_names_refseq": "ER flavoprotein associated with degradation; FAD-dependent oxidoreductase domain-containing protein 2 isoform 1 precursor; FAD-dependent oxidoreductase domain-containing protein 2; endoplasmic reticulum flavoprotein associated with degradation",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80020)",
        "pathway_count": 1,
        "publication_count": 56,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;18477386;19159218;19706418;21359175;23481700;24190977;24632291;25418920;25576301;25802875;25892735;26154972;26992070;27600516;27920218;28228285;28834231;28904123;29242379;29393594;29557506;29632046;29769354;29786170;30315122;30429286;30484775;31154438;31530632;31844290;31848261;32157095;32161166;32265295;32357974;32387766;32502341;32897882;32938616;33298915;33537174;33717175;33912179;33936100;33968037;34171305;35051231;35251023;35580925;36010968;36215666;36241641;36581221;37074911",
        "class_list": "",
        "function": "ERFAD facilitates the dislocation of certain endoplasmic reticulum-associated degradation substrates to the cytosol., [RefSeq, PubMed]; Expression of FOXRED2 increases activity of hypoxia-targeted prodrugs., [RefSeq, PubMed]; Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 9606,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDI4;Q8N378;Q96BD1;Q9H5L5;Q9H6M8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0004497 monooxygenase activity;GO:0016491 oxidoreductase activity",
        "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen",
        "go_biological_process": "GO:0036503 ERAD pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "Q8IWF2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UHL0-1",
        "uniprot_id": "DDX25_HUMAN",
        "mass": 54692.0,
        "length": 483,
        "protein_name": "ATP-dependent RNA helicase DDX25",
        "gene_name": "DDX25",
        "organism": "Human",
        "refseq_name": "ATP-dependent RNA helicase DDX25 isoform 2",
        "refseq_ac": "NP_001317367",
        "gene_names_uniprotkb": "DDX25; GRTH",
        "gene_names_refseq": "DDX25; GRTH",
        "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX25; 3.6.4.13; DEAD box protein 25; Gonadotropin-regulated testicular RNA helicase",
        "protein_names_refseq": "ATP-dependent RNA helicase DDX25 isoform 2; ATP-dependent RNA helicase DDX25; DEAD (Asp-Glu-Ala-Asp) box helicase 25; DEAD (Asp-Glu-Ala-Asp) box polypeptide 25; DEAD box protein 25; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 25; epididymis secretory sperm binding protein; gonadotropin-regulated testicular RNA helicase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:29118)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "10608860;11237011;16293649;17848414;20378615;20941364;24168058;28832583;29242379;29393594;31009948;31040297;31844290;32157095;33592498;34171305;35051231",
        "class_list": "",
        "function": "ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity)., [UniProtKB, PubMed]; Analysed the association of GRTH gene IVS6+55G/T and c.852C/T polymorphisms with male infertility. The c.852 T allele was associated with an increased risk of male infertility (OR: 3.16, P = 0.008), whereas IVS6+55G/T allele conferred no risk., [RefSeq, PubMed]; Characterization of the Phosphorylation Site of GRTH/DDX25 and Protein Kinase A Binding Interface Provides Structural Basis for the Design of a Non-Hormonal Male Contraceptive. Publication Status: Online-Only, [RefSeq, PubMed]; DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis. [provided by RefSeq, Jul 2008]., [RefSeq]; Data show that the Arg(242)His missense mutation of the GRTH/DDX25 gene associated with expression of a protein with reduced basicity, and the absence of the phospho-GRTH species, could impact on germ cell development and/or function. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; RNA helicase., [UniProtKB, UniProtKB]; SNP IVS6+55G-->T and c.852C-->T of GRTH gene may be associated with male infertility with azoospermia or severe oligozoospermia. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Targeted knock-in mice with a human mutation in GRTH/DDX25 reveals the essential role of phosphorylated GRTH in spermatid development during spermatogenesis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6Z0;Q5XVN2;Q86W81;Q8IYP1",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule;GO:0033391 chromatoid body",
        "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006406 mRNA export from nucleus;GO:0006417 regulation of translation;GO:0007286 spermatid development",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q9UHL0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P79483-1",
        "uniprot_id": "DRB3_HUMAN",
        "mass": 29962.0,
        "length": 266,
        "protein_name": "HLA class II histocompatibility antigen, DR beta 3 chain",
        "gene_name": "HLA-DRB3",
        "organism": "Human",
        "refseq_name": "major histocompatibility complex, class II, DR beta 3 precursor",
        "refseq_ac": "NP_072049",
        "gene_names_uniprotkb": "HLA-DRB3",
        "gene_names_refseq": "DRB3; HLA DRB3; HLA-DR3B; HLA-DRB3*; HLA-DRB3",
        "protein_names_uniprotkb": "HLA class II histocompatibility antigen, DR beta 3 chain; MHC class II antigen DRB3",
        "protein_names_refseq": "HLA class II histocompatibility antigen, DR beta 3 chain; MHC class II DR beta chain; MHC class II HLA-DR beta 3 chain; MHC class II antigen DR beta 3 chain; MHC class II antigen DRB3; MHC class II protein; human leucocyte antigen DRB3; major histocompatibility complex, class II, DR beta 3 precursor; major histocompatibility complex, class II, DRB3",
        "tax_id": 9606,
        "disease": "aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); Graves' disease (Disease Ontology:DOID:12361); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841)",
        "pathway": " (hsa:3125);  (R-HSA-202424);  (R-HSA-202427);  (R-HSA-202430);  (R-HSA-202433);  (R-HSA-2132295);  (R-HSA-389948);  (R-HSA-877300)",
        "pathway_count": 8,
        "publication_count": 272,
        "publication_id_list": "10036229;10064083;10067896;10072072;10480952;10540230;10593899;10599892;10631941;10631952;10639150;10671560;10698680;10716940;10747096;10748235;10790433;10809954;10811803;10902611;10958362;10986460;11048639;11098940;11358993;11380956;11390650;11529500;11607830;11684289;11752630;11790530;11813165;11827988;11853874;11884229;11894954;11972023;11972885;12040185;12078484;12198549;12438563;12446674;12473184;12485116;12660731;12742663;12748383;12893276;12915721;12938237;12944060;12947224;1396683;14510693;14514672;14586410;14722222;14731593;15084594;1508672;15104685;15122200;15125833;15140047;15143187;15145317;15322115;15358536;15371334;15388922;15489910;15489916;15496209;15530433;15541657;15749704;15911768;16056267;16148104;16181339;16237089;16242130;16356853;16356855;16364187;16461343;16467876;16612002;16618111;16824007;16978534;17047224;17072321;17125875;17135271;17142755;17283181;17363905;17468049;17496917;17548359;17583734;17652306;17728323;18046453;18173375;18292509;18305173;18362138;18566446;18591661;18697946;18759926;18764810;19000136;19494351;19531622;19535639;1956401;19564404;19706888;19830726;20049711;20130243;20304997;20346773;20363976;20368442;21116285;21154117;2121367;21441454;21543337;2190094;22426112;22929521;23061660;23302904;23510415;23569328;23580664;2391366;24190977;24417533;2463305;24715725;2471740;2530588;25502872;26154972;26992070;27862975;2788702;28165004;28265006;28904123;29557506;29741879;29863979;30282837;30429286;30522017;31020640;31154438;31308093;31313098;31333679;31611695;31844290;32157095;32162841;32265295;32341563;32350084;32357974;32462780;32488085;32897882;32983136;33043033;33091337;33123756;33141586;33239784;33298915;33565267;33592498;33912179;33936100;33968037;33981976;34087483;34211107;34357683;34433824;3459965;3476943;34932366;35051231;35154160;35318648;35580925;36241641;36284347;36286990;37074911;37938771;6414998;7479848;7481823;7510216;7514165;7530745;7565724;7592972;7615558;7617032;7650016;7657660;7667286;7673114;7690989;7796299;8046351;8134367;8145819;8148318;8156998;8176225;8313912;8397411;8415765;8483949;8520027;8530158;8550590;8550631;8601309;8631301;8642258;8687433;8798379;8824201;8849454;8909537;8939989;8947036;9075930;9111318;9115214;9143706;9162096;9202021;9234492;9234494;9243765;9252186;9311912;9312039;9362451;9389331;9497313;9539769;9545226;9606180;9687533;9802612;9846482;9850860;9990853",
        "class_list": "",
        "function": "A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB3-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells. Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:16148104, PubMed:19531622, PubMed:19830726, PubMed:20368442, PubMed:22929521, PubMed:23569328, PubMed:2463305, PubMed:2788702, PubMed:30282837, PubMed:31020640, PubMed:31308093, PubMed:31333679). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (By similarity). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (By similarity). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides. The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; ALLELE DRB3*01:01: Exclusively presents several immunogenic epitopes derived from C.tetani neurotoxin tetX, playing a significant role in immune recognition and long-term protection (PubMed:19830726, PubMed:2463305, PubMed:2788702). Presents viral epitopes derived from HHV-6B U11, TRX2/U56 and U85 antigens to polyfunctional CD4-positive T cells with cytotoxic activity implicated in control of HHV-6B infection (PubMed:31020640)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; ALLELE DRB3*02:02 Exclusively presents several immunogenic epitopes derived from C.tetani neurotoxin tetX, playing a significant role in immune recognition and long-term protection (PubMed:19830726, PubMed:2788702). Upon EBV infection, presents to CD4-positive T cells latent antigen EBNA2 (PRSPTVFYNIPPMPLPPSQL) and lytic antigen BZLF1 (LTAYHVSTAPTGSWF) peptides, driving oligoclonal expansion and selection of virus-specific memory T cell subsets with cytotoxic potential to directly eliminate virus-infected B cells (PubMed:23569328, PubMed:31308093). Presents viral epitopes derived from HHV-6B U11, gB/U39 and gH/U48 antigens to polyfunctional CD4-positive T cells with cytotoxic activity implicated in control of HHV-6B infection (PubMed:31020640). Plays a minor role in CD4-positive T cell immune response against Dengue virus by presenting conserved peptides from capsid and non-structural NS3 proteins (PubMed:31333679). Displays peptides derived from IAV matrix protein M, implying a role in protection against IAV infection (PubMed:19830726). In the context of tumor immunesurveillance, may present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (KRYFKLSHLQMHSRKH), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies (PubMed:22929521). Presents to Vbeta2-positive T-helper 1 cells specifically an immunodominant peptide derived from tumor antigen CTAG1A/NY-ESO-1(PGVLLKEFTVSGNILTIRLTAADHR) and confers protective memory response (PubMed:19531622, PubMed:20368442). In metastatic epithelial tumors, presents to intratumoral CD4-positive T cells a TP53 neoantigen (HYNYMCNSSCMGSMNRRPILTIITL) carrying G245S hotspot driver mutation and may mediate tumor regression (PubMed:30282837)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; ALLELE DRB3*03:01: Presents a series of conserved peptides derived from the M.tuberculosis PPE family of proteins, in particular PPE29 and PPE33, known to be highly immunogenic (PubMed:32341563). Presents immunogenic epitopes derived from C.tetani neurotoxin tetX, playing a role in immune recognition and long-term protection (PubMed:2788702). Displays immunodominant viral peptides from HCV non-structural protein NS2, as part of a broad range T-helper response to resolve infection (PubMed:16148104)., [UniProtKB, PubMed, PubMed, PubMed]; Characterization of the novel HLA-DRB3*02:02:25 allele by sequencing-based typing., [RefSeq, PubMed]; Characterization of the novel HLA-DRB3*03:49 allele by sequencing-based typing., [RefSeq, PubMed]; Full genomic sequence of the HLA-DRB3*02:32 allele by Single Molecule Real-time Sequencing Technology., [RefSeq, PubMed]; HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 8836,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0ZXY9;A7MA46;B5AU12;B5AU13;B5AU14;B8YAC6;C6H115;C6H116;O02875;O19590;O46701;O46794;O78049;O78162;P01913;P79663;Q29721;Q29809;Q2PPD0;Q30144;Q507L8;Q5SP44;Q5STE0;Q6YJU6;Q70M87;Q7YQ62;Q860I9;Q8SP69;Q8WLT7;Q8WLT8;Q95359;Q95HM8;Q95IE5;Q96H16;Q9BCP3;Q9BD18;Q9MYA4;Q9MYH3;Q9MYH4;Q9TP01;Q9TP02;Q9TPB5;Q9TQ21;Q9UIN3;Q9UIN5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding;GO:0032395 MHC class II receptor activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032588 trans-Golgi network membrane;GO:0005765 lysosomal membrane",
        "go_biological_process": "GO:0002842 positive regulation of T cell mediated immune response to tumor cell;GO:0007165 signal transduction;GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0050852 T cell receptor signaling pathway;GO:0002503 peptide antigen assembly with MHC class II protein complex",
        "synthesized_glycan_count": 0,
        "hit_score": 27.9,
        "record_id": "P79483-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IY81-1",
        "uniprot_id": "SPB1_HUMAN",
        "mass": 96558.0,
        "length": 847,
        "protein_name": "pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3",
        "gene_name": "FTSJ3",
        "organism": "Human",
        "refseq_name": "pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3",
        "refseq_ac": "NP_060117",
        "gene_names_uniprotkb": "FTSJ3; SB92",
        "gene_names_refseq": "EPCS3; FTSJ3; SPB1",
        "protein_names_uniprotkb": "pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; 2.1.1.-; Protein ftsJ homolog 3; Putative rRNA methyltransferase 3",
        "protein_names_refseq": "2'-O-ribose RNA methyltransferase SPB1 homolog; FtsJ RNA methyltransferase homolog 3; FtsJ homolog 3; SPB1 RNA methyltransferase homolog; pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; pre-rRNA processing protein FTSJ3; protein ftsJ homolog 3; putative rRNA methyltransferase 3; rRNA (uridine-2'-O-)-methyltransferase 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:117246);  (R-HSA-6791226)",
        "pathway_count": 2,
        "publication_count": 138,
        "publication_id_list": "11237011;11922599;12068309;12150911;12429849;16037817;16043514;16565220;16738141;16964243;17081983;17189298;17322306;17353269;17412707;17924679;18065403;18438418;18452278;18669648;18691976;18767875;19007248;19106111;19332556;19413330;19415658;19564402;19608861;19651622;19664994;19664995;19690332;19691289;19801658;20038530;20056613;20058876;20068231;20531386;20798176;20805244;20819938;21036871;21063389;21097556;21406692;21740066;22072790;22190735;22195017;22916032;23186163;23301498;23439679;23482395;2388630;24275569;24424021;24550520;25418920;25525153;25576301;25645385;25810538;25892735;25969445;26154972;26237581;26768311;26929215;26992070;27846572;27920218;28063628;28218747;28228285;28510447;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29769354;29786170;30315122;30379171;30429286;30484775;30626973;30779550;30833945;31154438;31222486;31530632;31844290;31848261;31957540;32119511;32157095;32161166;32265295;32350084;32357974;32502341;32897882;32938616;32983136;33214551;33592498;33717175;33912179;33968037;33981976;34019948;34087483;34171305;34185709;34229054;34932366;35051231;35083852;35318648;35580925;35705054;36010968;36241641;37217939;37963197;38665916;39534244;40914422;9482744",
        "class_list": "",
        "function": "(Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973)., [UniProtKB, PubMed]; Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis. [provided by RefSeq, Jul 2008]., [RefSeq]; Pan-cancer analysis of RNA methyltransferases identifies FTSJ3 as a potential regulator of breast cancer progression., [RefSeq, PubMed]; RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation., [UniProtKB, PubMed, HAMAP]; RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 32,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCA5;D3DU22;Q8N3A3;Q8WXX1;Q9BWM4;Q9NXT6",
        "ec_number_list": "2.1.1.-;3.6.5.-;3.6.4.13",
        "go_molecular_function": "GO:0016435 rRNA (guanine) methyltransferase activity;GO:0003723 RNA binding;GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity;GO:0062105 RNA 2'-O-methyltransferase activity;GO:0008168 methyltransferase activity",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0030688 preribosome, small subunit precursor",
        "go_biological_process": "GO:0031167 rRNA methylation;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0001510 RNA methylation;GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006364 rRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 14.3,
        "record_id": "Q8IY81-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P51148-1",
        "uniprot_id": "RAB5C_HUMAN",
        "mass": 23483.0,
        "length": 216,
        "protein_name": "Ras-related protein Rab-5C",
        "gene_name": "RAB5C",
        "organism": "Human",
        "refseq_name": "ras-related protein Rab-5C isoform b",
        "refseq_ac": "NP_001238968",
        "gene_names_uniprotkb": "RAB5C; RABL",
        "gene_names_refseq": "L1880; RAB5CL; RAB5C; RAB5L; RABL",
        "protein_names_uniprotkb": "Ras-related protein Rab-5C; 3.6.5.2; L1880; RAB5L",
        "protein_names_refseq": "RAB5C, member of RAS oncogene family; ras-related protein Rab-5C isoform b; ras-related protein Rab-5C",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557)",
        "pathway": " (hsa:5878);  (R-HSA-432722);  (R-HSA-6798695);  (R-HSA-8854214);  (R-HSA-8856828);  (R-HSA-8873719);  (R-HSA-8876198);  (R-HSA-9820960)",
        "pathway_count": 8,
        "publication_count": 436,
        "publication_id_list": "10202141;10394364;10535736;10542231;10559856;10559861;10559924;10625686;10766823;10768959;10818110;10990452;11038176;11082044;11141079;11179213;11231140;11237011;11239472;11389151;11447212;11470803;11477410;11516400;11516654;11517213;11532990;11577110;11590181;11604418;11675392;11689439;11694590;11703925;11746448;11784320;11877457;11877461;11889126;11917121;11994746;12057195;12058051;12213833;12221131;12244319;12364329;12427552;12447393;12475894;12493736;12684051;12847086;12944476;12952949;12972505;14555962;14581451;14617351;14622578;14622579;15096524;15102850;15138286;1516130;15247254;15252009;15260957;15318165;15339664;15388334;15502812;15502813;15528189;15561770;15649145;15692570;15703209;15802264;15878329;15895077;15914536;15916959;15958533;16055087;16086013;16103228;16155256;16207721;16215232;16326391;16373702;16395330;16401880;16410077;1648736;16516836;16525024;16525121;16571673;16641372;16707488;16754960;16798879;16880209;16880396;16903783;16950109;16959974;17018281;17035995;17043139;17081065;17114793;17116749;17132146;17158794;17189207;17208202;17239822;17287728;17411337;17488286;17494869;17512409;17540576;17562788;17574030;17609109;17646400;17658474;17671165;17678623;17681954;17762867;17765681;17901050;17978091;18076383;18093523;18094055;18199687;18319245;18354496;18367545;18388313;1845915;18466115;18477474;1847920;18512783;18532927;18559336;18585354;18664496;18701652;18779367;18790740;18804435;18981233;1900457;19092055;19109890;19287005;19296720;19345684;19403694;19458185;19490898;19536138;19575674;19603039;19620288;19656848;19696796;19713939;19725050;19729655;19745841;19776351;19809571;20008558;20033059;20059951;20095038;20116244;20154091;20159109;20159556;20211604;20231386;20305638;20308558;20363736;20404108;20428113;20434987;20448150;20592283;20797862;20826345;20851765;20937701;20946875;21041651;2115402;21183348;21187289;21187331;21216617;21273506;21278753;21316588;21330364;21383079;21421921;21445324;21458671;21482805;21499258;21532587;21554507;21586568;21613550;21683469;21706022;21718402;21750715;21776405;21779028;21841790;21883765;21927000;21927001;21951725;21962517;22013193;22065758;22072793;22099461;22171327;22219378;22233676;22365832;22433857;22484487;22505844;22511774;22581368;22595670;22613832;22622570;22648168;22653444;22694141;22705394;22762500;22795129;22815487;22854040;22863004;22908308;22983554;23019362;23084991;23091056;23147242;23176487;23176493;23220125;23239882;23247405;23263280;23295650;23297414;23301498;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23536704;23562278;23645161;23650620;23678941;23684622;23713133;23719902;23823722;23839779;23861397;23891661;24023390;24130457;24186068;24296415;24581490;24644286;24694596;24719330;24789820;24891604;24917561;24966051;24967941;25074980;25107275;25303366;25341920;25343031;25472813;25648148;25713415;25925668;26042225;26055712;26177209;26245486;26403691;26434594;26538022;26925400;26936971;26969162;27041585;27044746;27090790;27103185;27246931;27329675;27452731;27862975;28218747;28467828;28832583;28871256;28904123;29125462;29242379;29314611;29393594;29427996;29493099;29557506;29632711;30315122;30429286;30524438;30573663;30626607;30779550;30833945;31092671;31154438;31217245;31373491;31530632;31844290;31848261;32157095;32350084;32502341;32897882;32974215;32983136;33043033;33091337;33392160;33592498;33912179;33936100;33968037;33981976;34019948;34078123;34171305;34357683;34433824;34725712;35051231;35083852;35154160;35251023;35561310;35580925;36215666;36241641;36284347;36657426;37074911;37213158;37552066;37938771;38242290;38665916;40596516;6146630;7688123;7877694;7911226;7951316;7957092;7991565;8144603;8164745;8349690;8374173;8375503;8408203;8513495;8522602;8524399;8552632;8631982;8646882;8662963;8670264;8692836;8836150;8863739;9020086;9020161;9030515;9092476;9100026;9136770;9323142;9427626;9428629;9590177;9635431;9733780;9736607",
        "class_list": "",
        "function": "Effects of miR-145 targeting rab5c and regulating MAPK / ERK signaling pathway on proliferation and invasion of thyroid papillary carcinoma cells. Publication Status: Online-Only, [RefSeq, PubMed]; Long Non-Coding RNA BCAR4 Promotes Oxaliplatin Resistance in Colorectal Cancer by Modulating miR-484-3p/RAB5C Expression., [RefSeq, PubMed]; Macrocephaly and developmental delay caused by missense variants in RAB5C., [RefSeq, PubMed]; Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]).[supplied by OMIM, Nov 2010]., [RefSeq]; Rab5c promotes RSV and ADV replication by autophagy in respiratory epithelial cells., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:16086013, PubMed:17562788). Involved in early endocytic trafficking (PubMed:16086013, PubMed:17562788). Required for EEA1 recruitment to early endosomes (PubMed:16086013, PubMed:17562788). Required for EGF and transferrin endocytosis and trafficking through early endosomes (PubMed:16086013, PubMed:17562788)., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F8W1H5;Q6FH55;Q9P0Y5",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;2.7.1.153;2.7.1.137;2.7.1.154;3.2.1.25;2.7.11.1;3.1.3.-;3.6.1.5;3.4.17.22;3.5.1.92;2.7.10.1;3.2.1.20;2.5.1.18;3.6.4.10;5.6.1.6;2.4.1.-;2.4.1.275;2.4.1.22;2.4.1.38;2.4.1.90;3.1.3.5;3.1.3.2;3.1.3.48;2.3.2.27;3.6.1.-;3.4.16.2;3.4.23.-;2.5.1.60;3.6.4.-;3.6.5.4;3.1.3.86;3.1.3.56;3.1.3.36;7.6.2.-;3.6.-.-;2.3.1.51;2.3.1.23;2.3.1.67;2.3.1.25;3.6.1.15;3.6.1.6;3.6.1.42;7.6.2.1",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity",
        "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0016197 endosomal transport;GO:0048227 plasma membrane to endosome transport",
        "synthesized_glycan_count": 0,
        "hit_score": 44.2,
        "record_id": "P51148-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BPU6-1",
        "uniprot_id": "DPYL5_HUMAN",
        "mass": 61421.0,
        "length": 564,
        "protein_name": "Dihydropyrimidinase-related protein 5",
        "gene_name": "DPYSL5",
        "organism": "Human",
        "refseq_name": "dihydropyrimidinase-related protein 5",
        "refseq_ac": "NP_001240652",
        "gene_names_uniprotkb": "DPYSL5; CRMP5; ULIP6",
        "gene_names_refseq": "CRAM; CRMP-5; CRMP5; CV2; DPYSL5; RTSC4; Ulip6",
        "protein_names_uniprotkb": "Dihydropyrimidinase-related protein 5; CRAM; CRMP-5; CRMP3-associated molecule; Collapsin response mediator protein 5; DRP-5; ULIP-6; UNC33-like phosphoprotein 6",
        "protein_names_refseq": "CRMP3-associated molecule; DRP-5; ULIP-6; UNC33-like phosphoprotein 6; collapsin response mediator protein-5; dihydropyrimidinase-related protein 5",
        "tax_id": 9606,
        "disease": "Ritscher-Schinzel syndrome (Disease Ontology:DOID:0060565); Ritscher-Schinzel syndrome 4 (MONDO:MONDO:0030331)",
        "pathway": " (hsa:56896);  (R-HSA-399956)",
        "pathway_count": 2,
        "publication_count": 21,
        "publication_id_list": "11034345;11220734;11237011;12093729;12372285;14685275;15652488;15676027;17287340;17607942;17607944;25040932;29393594;29485866;31092671;31154438;31844290;32157095;33894126;35051231;37938771",
        "class_list": "",
        "function": "Involved in the negative regulation of dendrite outgrowth., [UniProtKB, PubMed]; Missense variants in DPYSL5 cause a neurodevelopmental disorder with corpus callosum agenesis and cerebellar abnormalities., [RefSeq, PubMed]; This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8TCL6;Q9NQC4;Q9NRY9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0050774 negative regulation of dendrite morphogenesis;GO:0007411 axon guidance",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q9BPU6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q02487-1",
        "uniprot_id": "DSC2_HUMAN",
        "mass": 99962.0,
        "length": 901,
        "protein_name": "Desmocollin-2",
        "gene_name": "DSC2",
        "organism": "Human",
        "refseq_name": "desmocollin-2 isoform Dsc2b preproprotein",
        "refseq_ac": "NP_004940",
        "gene_names_uniprotkb": "DSC2; CDHF2; DSC3",
        "gene_names_refseq": "ARVD11; CDHF2; DG2; DGII/III; DSC2; DSC3",
        "protein_names_uniprotkb": "Desmocollin-2; Cadherin family member 2; Desmocollin-3; Desmosomal glycoprotein III; Desmosomal glycoprotein II",
        "protein_names_refseq": "cadherin family member 2; desmocollin-2 isoform Dsc2b preproprotein; desmosomal glycoprotein II/III",
        "tax_id": 9606,
        "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); arrhythmogenic right ventricular dysplasia 11 (Disease Ontology:DOID:0110082); retinitis pigmentosa 62 (Disease Ontology:DOID:0110380); dilated cardiomyopathy (Disease Ontology:DOID:12930); acute myocardial infarction (Disease Ontology:DOID:9408)",
        "pathway": " (hsa:1824);  (R-HSA-6805567);  (R-HSA-6809371)",
        "pathway_count": 3,
        "publication_count": 108,
        "publication_id_list": "37268159;10.1101/2023.09.13.557529;10066784;10196183;10231017;10411887;10588656;10771479;11237011;11350120;11380615;11590230;12902340;15033990;15337775;15373777;15797384;15803139;15951569;16061697;16335952;16382671;16639001;16740002;1691188;1694855;17016520;17033975;1714783;17515931;17521629;17562024;17596512;17963498;18678517;18843291;19139490;19190773;19194479;19863551;20031617;20179351;2037591;20657595;20667819;20940292;21062920;21439340;21654840;21997417;23090970;23481192;23629652;23863954;2414304;24190977;24275569;24793512;25208567;25208914;25502872;25926655;26310507;26375851;26390218;26992070;27846572;28256248;28467828;28855257;29242379;29317506;29391424;29508533;29557506;29671580;29741879;29789417;31154438;31217245;31611695;31844290;31967937;32125861;32350084;32387766;32502341;33158670;33537174;33596089;33784018;33968037;34171305;35051231;35251023;35580925;36010968;36284347;36768812;37074911;37421607;38671389;7543090;8824274;8999895;9395522;9468612;9565599",
        "class_list": "",
        "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; DSC2 suppresses the growth of gastric cancer through the inhibition of nuclear translocation of gamma-catenin and PTEN/PI3K/AKT signaling pathway., [RefSeq, PubMed]; Desmoglein 2 and desmocollin 2 depletions promote malignancy through distinct mechanisms in triple-negative and luminal breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 4,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 6,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 72,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 70,
        "disease_count": 5,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0070062 extracellular exosome;GO:0014704 intercalated disc;GO:0031410 cytoplasmic vesicle",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0086091 regulation of heart rate by cardiac conduction;GO:0098609 cell-cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:1900745 positive regulation of p38MAPK cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 18.9,
        "record_id": "Q02487-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TAE8-1",
        "uniprot_id": "G45IP_HUMAN",
        "mass": 25384.0,
        "length": 222,
        "protein_name": "Large ribosomal subunit protein mL64",
        "gene_name": "GADD45GIP1",
        "organism": "Human",
        "refseq_name": "large ribosomal subunit protein mL64",
        "refseq_ac": "NP_443082",
        "gene_names_uniprotkb": "GADD45GIP1; MRPL59; PLINP1; PRG6",
        "gene_names_refseq": "CKBBP2; CKbetaBP2; CRIF1; GADD45GIP1; MRP-L59; PLINP-1; PLINP; PRG6; Plinp1; mL64",
        "protein_names_uniprotkb": "Large ribosomal subunit protein mL64; 39S ribosomal protein L59, mitochondrial; CKII beta-associating protein; CR6-interacting factor 1; CRIF1; Growth arrest and DNA damage-inducible proteins-interacting protein 1; MRP-L59; PLINP-1; PLINP; Papillomavirus L2-interacting nuclear protein 1; p53-responsive gene 6 protein",
        "protein_names_refseq": "39S ribosomal protein L59, mitochondrial; CKII beta binding protein 2; CKII beta-associating protein; CR6 interacting factor 1; growth arrest and DNA damage-inducible proteins-interacting protein 1; growth arrest and DNA-damage-inducible, gamma interacting protein 1; growth arrest- and DNA damage-inducible GADD45G-interacting protein; large ribosomal subunit protein mL64; mitochondrial large ribosomal subunit protein CRIF1; mitochondrial large ribosomal subunit protein mL64; p53-responsive gene 6 protein; papillomavirus L2 interacting nuclear protein 1",
        "tax_id": 9606,
        "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:90480);  (R-HSA-5368286);  (R-HSA-5389840);  (R-HSA-5419276);  (R-HSA-9937383)",
        "pathway_count": 5,
        "publication_count": 65,
        "publication_id_list": "10441517;12482659;12716909;15358359;15459248;17069992;17803939;18429816;18782833;19524667;19716793;20068231;20186120;21907147;22172991;22453275;2250005;23481700;23908630;25233460;25278503;25576301;25838379;26154972;26375851;27023846;27029019;27846572;28510447;28832583;28892042;29242379;29437277;29557506;30192525;31217245;31844290;32157095;32350084;32387766;32502341;32938616;32983136;33141586;33243891;33392160;33878294;33912179;33968037;34211107;34405274;34509645;35051231;35177605;35251023;35561310;35716330;36215666;36241641;36302763;36596788;37141370;37648779;38536932;38665916",
        "class_list": "",
        "function": "Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis., [UniProtKB]; CRIF1 deficiency induces FOXP3[LOW] inflammatory non-suppressive regulatory T cells, thereby promoting antitumor immunity., [RefSeq, PubMed]; CRIF1 promotes the progression of non-small-cell lung cancer by SIRT3- mediated deacetylation of PYCR1., [RefSeq, PubMed]; Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism. Erratum:[Mol Psychiatry. 2023 Oct;28(10):4485. doi: 10.1038/s41380-023-02254-1. PMID: 37783789], [RefSeq, PubMed]; Phosphorylation of serine-221 in CKBBP2/CRIF1 promotes proliferation of green monkey COS7 cells., [RefSeq, PubMed]; Results suggest that CRIF1 is a novel nuclear protein that interacts with Gadd45 and may play a role in negative regulation of cell cycle progression and cell growth, [RefSeq, PubMed]; This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IVM3;Q8TE51;Q969P9;Q9BSM6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003735 structural constituent of ribosome",
        "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0032543 mitochondrial translation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.8,
        "record_id": "Q8TAE8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P02008-1",
        "uniprot_id": "HBAZ_HUMAN",
        "mass": 15637.0,
        "length": 142,
        "protein_name": "Hemoglobin subunit zeta",
        "gene_name": "HBZ",
        "organism": "Human",
        "refseq_name": "hemoglobin subunit zeta",
        "refseq_ac": "NP_005323",
        "gene_names_uniprotkb": "HBZ; HBZ2",
        "gene_names_refseq": "HBAZ; HBZ-T1; HBZ1; HBZ",
        "protein_names_uniprotkb": "Hemoglobin subunit zeta; HBAZ; Hemoglobin zeta chain; Zeta-globin",
        "protein_names_refseq": "hemoglobin subunit zeta; hemoglobin zeta chain; hemoglobin, zeta; zeta-globin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3050)",
        "pathway_count": 1,
        "publication_count": 32,
        "publication_id_list": "11237011;11747442;1939469;19664994;20925047;22898188;23186163;24100324;24751163;25469497;26154972;27893789;29557506;30418433;31844290;32350084;32357974;32387766;33091337;33392160;33592498;35251023;36215666;36284347;37565279;6171809;6172357;6179844;6297773;6539334;6963223;9054936",
        "class_list": "",
        "function": "Assessment of Bcl-xL, TAX, and HBZ Gene Expression in Adult T cell Leukemia/Lymphoma Patients., [RefSeq, PubMed]; Data indicate a tetranucleotide 3'UTR motif that is required for the high-level accumulation of zeta-globin transcripts in cultured cells, and demonstrate that it prolongs their cytoplasmic half-lives. Publication Status: Online-Only, [RefSeq, PubMed]; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin., [UniProtKB, UniProtKB, UniProtKB]; Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'. [provided by RefSeq, Nov 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IBF6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex",
        "go_biological_process": "GO:0015670 carbon dioxide transport;GO:0048821 erythrocyte development;GO:0015671 oxygen transport",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "P02008-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P86480-1",
        "uniprot_id": "PR20D_HUMAN",
        "mass": 23262.0,
        "length": 221,
        "protein_name": "Proline-rich protein 20D",
        "gene_name": "PRR20D",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "PRR20D",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Proline-rich protein 20D",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:122183);  (hsa:729233);  (hsa:729240);  (hsa:729246);  (hsa:729250)",
        "pathway_count": 5,
        "publication_count": 1,
        "publication_id_list": "34087483",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N7V5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "P86480-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13882-1",
        "uniprot_id": "PTK6_HUMAN",
        "mass": 51834.0,
        "length": 451,
        "protein_name": "Protein-tyrosine kinase 6",
        "gene_name": "PTK6",
        "organism": "Human",
        "refseq_name": "protein-tyrosine kinase 6 isoform 2",
        "refseq_ac": "NP_001243287",
        "gene_names_uniprotkb": "PTK6; BRK",
        "gene_names_refseq": "BRK; PTK6",
        "protein_names_uniprotkb": "Protein-tyrosine kinase 6; 2.7.10.2; Breast tumor kinase; Tyrosine-protein kinase BRK",
        "protein_names_refseq": "PTK6 protein tyrosine kinase 6; breast tumor kinase; protein-tyrosine kinase 6 isoform 2; protein-tyrosine kinase BRK; tyrosine-protein kinase BRK",
        "tax_id": 9606,
        "disease": "intestinal cancer (Disease Ontology:DOID:10155); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:5753);  (R-HSA-187577);  (R-HSA-69231);  (R-HSA-8847993);  (R-HSA-8849468);  (R-HSA-8849469);  (R-HSA-8849470);  (R-HSA-8849471);  (R-HSA-8849472);  (R-HSA-8849473);  (R-HSA-8849474);  (R-HSA-8857538);  (R-HSA-9707564)",
        "pathway_count": 13,
        "publication_count": 153,
        "publication_id_list": "10207050;10323868;10375532;10385618;10499802;10559916;10831586;10913193;10980601;11032757;11073976;11114724;11157749;11231573;11231585;11416152;11719808;11884610;12121988;12435635;12444543;12482964;12540842;12787671;12833144;12969439;1423597;14517297;14597415;15056653;15199159;15471878;15509496;15539407;15572663;15579463;15870689;15961400;16179349;16195327;16209941;16300827;16308318;16568091;16651629;16782892;17016520;17092340;17254966;17254967;17264172;17344846;17389395;17822667;17908796;17997837;1828392;1828393;1828394;18296648;18414028;18691976;18710949;18719096;18827403;18829532;19075005;19393627;19439179;19458076;19487459;19690164;19968714;20026641;20107323;20193745;20554524;20606012;20663872;20843055;20929863;20952511;21098664;21423214;21479203;21715330;22084245;22231447;22311708;22427940;22547065;23007395;23352614;23443682;23552639;23622515;23737759;23814047;23928995;24515438;24523872;24876129;25019382;25153721;25733683;25897081;25938342;26751287;26825173;27480927;27993680;28698372;29142193;29879184;30711375;31543423;32938616;33592498;33912179;33968037;3427020;3475708;35051231;36284347;36690663;36854171;37216999;37217939;39098513;6094553;7797074;7954814;8036022;8114739;8139570;8246996;8336704;8497257;8940083;9042862;9106657;9144196;9185712;9190208;9219684;9302992;9325318;9333026;9407060;9447971;9448290;9508775;9749526",
        "class_list": "",
        "function": "Alternative transcript-PTK6 is able to negatively regulate growth and modulate PTK6 activity, protein-protein associations and/or subcellular localization. Publication Status: Online-Only, [RefSeq, PubMed]; BRK confers tamoxifen-resistance in breast cancer via regulation of tyrosine phosphorylation of CDK1., [RefSeq, PubMed]; Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk., [RefSeq, PubMed]; Circular RNA hsa_circ_0001610 promotes prostate cancer progression by sponging miR-1324 and upregulating PTK6., [RefSeq, PubMed]; Inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins., [UniProtKB]; Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Phosphorylates the GTPase-activating protein ARAP1 following EGF stimulation which enhances EGFR signaling by delaying EGFR down-regulation (PubMed:20554524). Also associates with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways., [UniProtKB, PubMed]; PTK6 inhibits autophagy to promote uveal melanoma tumorigenesis by binding to SOCS3 and regulating mTOR phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 16,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCR3;B4DW46;Q58F01",
        "ec_number_list": "2.7.12.2;2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;1.14.14.18;2.7.11.22;2.7.1.40;3.1.3.48;2.3.2.27;2.7.1.32;2.7.1.82;2.7.10.4;2.7.11.13;2.7.11.23;3.6.5.-",
        "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010976 positive regulation of neuron projection development;GO:0016477 cell migration;GO:0030154 cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 15.6,
        "record_id": "Q13882-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UL26-1",
        "uniprot_id": "RB22A_HUMAN",
        "mass": 21855.0,
        "length": 194,
        "protein_name": "Ras-related protein Rab-22A",
        "gene_name": "RAB22A",
        "organism": "Human",
        "refseq_name": "ras-related protein Rab-22A",
        "refseq_ac": "NP_065724",
        "gene_names_uniprotkb": "RAB22A; RAB22",
        "gene_names_refseq": "RAB22A",
        "protein_names_uniprotkb": "Ras-related protein Rab-22A; 3.6.5.2; Rab-22",
        "protein_names_refseq": "GTP-binding protein RAB22A; rab-22; ras-related protein Rab-22A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57403);  (R-HSA-8873719)",
        "pathway_count": 2,
        "publication_count": 46,
        "publication_id_list": "10887961;11141079;11389151;11447212;11675392;11870209;16401880;1648736;16537905;17114793;17411337;18532927;19603039;21255211;21419809;21849477;22694141;24023390;25341920;26969162;29242379;29317506;31217245;31844290;32350084;32357974;32475639;32897882;32938616;33968037;34357683;35251023;36762583;36892682;38431306;38647725;39206796;7957092;7991565;8164745;8349690;8375503;8513495;8631982;8662963;8836150",
        "class_list": "",
        "function": "Circ-C16orf62 Regulates Oxidized low-density Lipoprotein-induced Apoptosis, Inflammation, Oxidative Stress and Cholesterol Accumulation of Macrophages via Mediating RAB22A Expression by Targeting miR-377., [RefSeq, PubMed]; Genomic Amplification of TBC1D31 Promotes Hepatocellular Carcinoma Through Reducing the Rab22A-Mediated Endolysosomal Trafficking and Degradation of EGFR., [RefSeq, PubMed]; RAB22A as a predictor of exosome secretion in the progression and relapse of multiple myeloma., [RefSeq, PubMed]; Rab22a may regulate the dynamic interactions of endosomal compartments and it may be involved in the communication between the biosynthetic and early endocytic pathways., [RefSeq, PubMed]; The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. [provided by RefSeq, Jul 2008]., [RefSeq]; The ras-related protein RAB22A interacts with hypoxia-inducible factor 1-alpha (HIF-1alpha) in MDA-MB-231 breast cancer cells in hypoxia. Publication Status: Online-Only, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:16537905, PubMed:21849477). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:16537905). RAB22A plays a role in endocytosis and intracellular protein transport. Mediates trafficking of transferrin/TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Has low GTPase activity (PubMed:16537905)., [UniProtKB, PubMed, PubMed]; Vps9d1 regulates tubular endosome formation through specific activation of Rab22A., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KR86;E1P605;Q8TF12;Q9H4E6",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.1.-;2.5.1.60;3.6.5.4;2.7.11.1;3.6.-.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity",
        "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0070062 extracellular exosome;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0007032 endosome organization;GO:0097494 regulation of vesicle size",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "Q9UL26-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q01959-1",
        "uniprot_id": "SC6A3_HUMAN",
        "mass": 68495.0,
        "length": 620,
        "protein_name": "Sodium-dependent dopamine transporter",
        "gene_name": "SLC6A3",
        "organism": "Human",
        "refseq_name": "sodium-dependent dopamine transporter",
        "refseq_ac": "NP_001035",
        "gene_names_uniprotkb": "SLC6A3; DAT1",
        "gene_names_refseq": "DAT1; DAT; PKDYS1; PKDYS; SLC6A3",
        "protein_names_uniprotkb": "Sodium-dependent dopamine transporter; DA transporter; DAT; Solute carrier family 6 member 3",
        "protein_names_refseq": "DA transporter; dopamine transporter 1; sodium-dependent dopamine transporter; solute carrier family 6 (neurotransmitter transporter), member 3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3",
        "tax_id": 9606,
        "disease": "nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041); classic dopamine transporter deficiency syndrome (Disease Ontology:DOID:0070489); mild cognitive impairment (Disease Ontology:DOID:0080832); Parkinsonism (Disease Ontology:DOID:0080855); dopamine beta-hydroxylase deficiency (Disease Ontology:DOID:0090145); hypertension (Disease Ontology:DOID:10763); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); hyperprolactinemia (Disease Ontology:DOID:12700); high grade glioma (Disease Ontology:DOID:3070); schizophrenia (Disease Ontology:DOID:5419); amphetamine abuse (Disease Ontology:DOID:670); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)",
        "pathway": " (hsa:6531);  (R-HSA-379397);  (R-HSA-379398);  (R-HSA-379401);  (R-HSA-442660);  (R-HSA-5619081);  (R-HSA-5660724)",
        "pathway_count": 7,
        "publication_count": 71,
        "publication_id_list": "10375632;10391209;10446133;10684912;10889531;10973981;11093780;11237011;11304827;11343649;11357798;11698620;11897791;12115694;12151341;12177201;13416264;1353885;1359373;1406597;15286787;15286788;15505207;15592994;15632147;16226721;16751771;16959974;17296554;17502375;17726476;17934207;18599538;18794526;18953341;19146407;19478460;2008212;20976142;21112253;21179162;22514303;23161550;2387399;24847974;24880859;26442590;28571709;29557506;30315122;31844290;33592498;33912179;37726104;39112701;39112703;39112705;4398930;6408492;7637582;7651355;7703232;7874447;8125921;8183239;8302271;8515683;8632143;9300814;9537821;9845349",
        "class_list": "",
        "function": "Association between longitudinal changes in striatal dopamine transporter uptake and clinical features of dementia with Lewy bodies., [RefSeq, PubMed]; Mediates sodium- and chloride-dependent transport of dopamine (PubMed:10375632, PubMed:11093780, PubMed:1406597, PubMed:15505207, PubMed:19478460, PubMed:39112701, PubMed:39112703, PubMed:39112705, PubMed:8302271). Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Mediates sodium- and chloride-dependent transport of dopamine. Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Structure of the human dopamine transporter in complex with cocaine. Erratum:[Nature. 2025 May;641(8062):E3. doi: 10.1038/s41586-025-08976-2. PMID: 40263454], [RefSeq, PubMed]; This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 17,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 15,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RUN4;Q14996",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0005334 norepinephrine:sodium symporter activity;GO:0002020 protease binding;GO:0005102 signaling receptor binding;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030424 axon",
        "go_biological_process": "GO:0015844 monoamine transport;GO:1990384 hyaloid vascular plexus regression;GO:0035094 response to nicotine;GO:0045471 response to ethanol;GO:0006865 amino acid transport",
        "synthesized_glycan_count": 0,
        "hit_score": 7.4,
        "record_id": "Q01959-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43805-1",
        "uniprot_id": "SSNA1_HUMAN",
        "mass": 13596.0,
        "length": 119,
        "protein_name": "Microtubule nucleation factor SSNA1",
        "gene_name": "SSNA1",
        "organism": "Human",
        "refseq_name": "microtubule nucleation factor SSNA1",
        "refseq_ac": "NP_003722",
        "gene_names_uniprotkb": "SSNA1; NA14",
        "gene_names_refseq": "N14; NA-14; NA14; SSNA1",
        "protein_names_uniprotkb": "Microtubule nucleation factor SSNA1; Nuclear autoantigen of 14 kDa; Sjoegren syndrome nuclear autoantigen 1",
        "protein_names_refseq": "Sjogren syndrome nuclear autoantigen 1; Sjogren's syndrome nuclear autoantigen 1; microtubule nucleation factor SSNA1; nuclear autoantigen of 14 kDa; sjoegren syndrome nuclear autoantigen 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8636);  (R-HSA-2565942);  (R-HSA-380259);  (R-HSA-380270);  (R-HSA-380284);  (R-HSA-380320);  (R-HSA-5620912);  (R-HSA-8854518)",
        "pathway_count": 8,
        "publication_count": 102,
        "publication_id_list": "11076968;11237011;11956313;12207013;12221128;12364337;12640030;12852856;13678582;14580337;14654843;15269182;15498487;15705883;16357211;16462731;16890155;16959974;17574030;17646400;17719545;18037885;1820200;18378770;18477460;18521620;18566290;18615013;18694559;18801063;19004860;19081074;19940019;20230748;20308558;20399632;20558667;21273506;21347367;21422230;21548880;21565611;21620453;21725307;21792235;22008182;22094468;22179047;22365832;22433857;22641346;22653444;23141531;23141541;23253480;23348840;23400999;23530209;23747070;23769972;23789104;23921553;24053599;24089205;24231678;24469809;24982133;25047611;25313408;25390646;25532896;25576301;28832583;29242379;29393594;29557506;30779550;30833945;31154438;31844290;31848261;32157095;32387766;32488085;32897882;32938616;33298915;33402344;33912179;33968037;33981976;34087483;34171305;34509645;34970964;35051231;36010968;37500134;7769006;7790358;8838651;9430706",
        "class_list": "",
        "function": "Microtubule-binding protein which stabilizes dynamic microtubules by slowing growth and shrinkage at both plus and minus ends and serves as a sensor of microtubule damage, protecting microtubules from the microtubule-severing enzyme SPAST (PubMed:34970964). Induces microtubule branching which is mediated by the formation of long SSNA1 fibrils which guide microtubule protofilaments to split apart from the mother microtubule and form daughter microtubules (By similarity). Plays a role in axon outgrowth and branching (PubMed:25390646). Required for cell division (PubMed:25390646)., [UniProtKB, PubMed, PubMed, UniProtKB]; SSNA1 Promotes Hepatocellular Carcinoma Metastasis Via STAT3/EMT Induction., [RefSeq, PubMed]; SSNA1 stabilizes dynamic microtubules and detects microtubule damage. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VSG0;Q6FG70;Q9BVW8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0099512 supramolecular fiber;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0030424 axon",
        "go_biological_process": "GO:0007409 axonogenesis;GO:0051301 cell division;GO:0007020 microtubule nucleation;GO:0000226 microtubule cytoskeleton organization;GO:0048675 axon extension",
        "synthesized_glycan_count": 0,
        "hit_score": 10.3,
        "record_id": "O43805-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y2L9-1",
        "uniprot_id": "LRCH1_HUMAN",
        "mass": 80875.0,
        "length": 728,
        "protein_name": "Leucine-rich repeat and calponin homology domain-containing protein 1",
        "gene_name": "LRCH1",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat and calponin homology domain-containing protein 1 isoform 1",
        "refseq_ac": "NP_001157683",
        "gene_names_uniprotkb": "LRCH1; CHDC1; KIAA1016",
        "gene_names_refseq": "CHDC1; LRCH1; NP81",
        "protein_names_uniprotkb": "Leucine-rich repeat and calponin homology domain-containing protein 1; Calponin homology domain-containing protein 1; NP81; Neuronal protein 81",
        "protein_names_refseq": "leucine-rich repeat and calponin homology domain-containing protein 1 isoform 1; leucine-rich repeat and calponin homology domain-containing protein 1; leucine-rich repeats and calponin homology (CH) domain containing 1; neuronal protein 81",
        "tax_id": 9606,
        "disease": "multiple sclerosis (Disease Ontology:DOID:2377)",
        "pathway": " (hsa:23143)",
        "pathway_count": 1,
        "publication_count": 51,
        "publication_id_list": "11237011;16447229;16891653;18049793;18669648;19664994;20068231;20237151;23186163;24275569;24714562;25645385;25880248;26375851;27869121;27920218;28028151;28063628;28228285;28832583;28904123;29242379;29508533;29557506;29786170;29789417;30315122;30429286;31844290;31848261;31998317;32157095;32161166;32350084;32357974;32387766;32488085;32727906;32938616;33298915;33392160;33912179;33968037;34087483;34357683;34561969;34932366;35051231;35154160;35318648;38665916",
        "class_list": "",
        "function": "A genetic variant in LRCH1 was consistently associated with knee osteoarthritis in 3 samples from 2 populations. GeneRIF: Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration., [UniProtKB, PubMed]; LRCH1 deficiency enhances LAT signalosome formation and CD8(+) T cell responses against tumors and pathogens., [RefSeq, PubMed]; Meta-analysis and HuGE review of gene-disease association. (HuGE Navigator) Review article, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Results suggest that there is no association between LRCH1 and knee osteoarthritis susceptibility, [RefSeq, PubMed]; This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2010]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZLL5;F8W6F0;Q17R43;Q2KHR1;Q5TBU9;Q7Z5F6;Q7Z5F7",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:1990869 cellular response to chemokine;GO:0034260 negative regulation of GTPase activity;GO:2000405 negative regulation of T cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q9Y2L9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N1N2-1",
        "uniprot_id": "DYNAP_HUMAN",
        "mass": 19573.0,
        "length": 184,
        "protein_name": "Dynactin-associated protein",
        "gene_name": "DYNAP",
        "organism": "Human",
        "refseq_name": "dynactin-associated protein isoform 1",
        "refseq_ac": "NP_775900",
        "gene_names_uniprotkb": "DYNAP; C18orf26",
        "gene_names_refseq": "C18orf26; DYNAP",
        "protein_names_uniprotkb": "Dynactin-associated protein; Full",
        "protein_names_refseq": "dynactin-associated protein isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:284254)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "11237011;20978158",
        "class_list": "",
        "function": "DynAP, which promotes activation of Akt, can be a new target for cancer therapy., [RefSeq, PubMed]; Plays a role in the regulation of cell proliferation. Promotes activation of the AKT1 signaling pathway. Promotes phosphorylation of AKT1 at 'Ser-473'., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A3B3IRJ4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane",
        "go_biological_process": "GO:1901625 cellular response to ergosterol;GO:0008284 positive regulation of cell population proliferation;GO:0032148 activation of protein kinase B activity;GO:0042981 regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q8N1N2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P52179-1",
        "uniprot_id": "MYOM1_HUMAN",
        "mass": 187627.0,
        "length": 1685,
        "protein_name": "Myomesin-1",
        "gene_name": "MYOM1",
        "organism": "Human",
        "refseq_name": "myomesin-1 isoform a",
        "refseq_ac": "NP_003794",
        "gene_names_uniprotkb": "MYOM1",
        "gene_names_refseq": "MYOM1; SKELEMIN",
        "protein_names_uniprotkb": "Myomesin-1; 190 kDa connectin-associated protein; 190 kDa titin-associated protein; Myomesin family member 1",
        "protein_names_refseq": "190 kDa connectin-associated protein; 190 kDa titin-associated protein; EH-myomesin; myomesin (M-protein) 1 (190kD); myomesin 1 (skelemin) 185kDa; myomesin 1, 185kDa; myomesin family member 1; myomesin-1 isoform a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8736)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "11237011;15188056;23481700;25152160;25548167;26154972;27862975;27989621;28832583;29557506;30379171;30429286;31844290;32157095;32488085;32502341;32938616;33452765;35051231;35580925;36010968;36284347;37217939;38253038;39531497;7505783",
        "class_list": "",
        "function": "Crystal structure of the obscurin(-like-1):myomesin complex reveals a trans-complementation mechanism whereby an incomplete immunoglobulin-like domain assimilates an isoform-specific myomesin interdomain sequence., [RefSeq, PubMed]; Individual subfragments of titin and myomesin composed of Fn type III and Ig-like domains can activate expression of two IGF-1 splice forms in cultured myoblasts, [RefSeq, PubMed]; Knockout of MYOM1 in human cardiomyocytes leads to myocardial atrophy via impairing calcium homeostasis., [RefSeq, PubMed]; Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent., [UniProtKB]; The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 52,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14BD6;Q6H969;Q6ZUU0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0019900 kinase binding;GO:0008307 structural constituent of muscle",
        "go_cellular_component": "GO:0031430 M band;GO:0005863 striated muscle myosin thick filament",
        "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0045214 sarcomere organization;GO:0002074 extraocular skeletal muscle development;GO:0141163 positive regulation of cAMP/PKA signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "P52179-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q99836-1",
        "uniprot_id": "MYD88_HUMAN",
        "mass": 33233.0,
        "length": 296,
        "protein_name": "Myeloid differentiation primary response protein MyD88",
        "gene_name": "MYD88",
        "organism": "Human",
        "refseq_name": "myeloid differentiation primary response protein MyD88 isoform 5",
        "refseq_ac": "NP_001166037",
        "gene_names_uniprotkb": "MYD88",
        "gene_names_refseq": "IMD68; MYD88D; MYD88; WM1",
        "protein_names_uniprotkb": "Myeloid differentiation primary response protein MyD88",
        "protein_names_refseq": "TLR adaptor MYD88; mutant myeloid differentiation primary response 88; myeloid differentiation primary response 88; myeloid differentiation primary response gene (88); myeloid differentiation primary response protein MyD88 isoform 5; myeloid differentiation primary response protein MyD88",
        "tax_id": 9606,
        "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); lymphoplasmacytic lymphoma (Disease Ontology:DOID:0060901); colorectal carcinoma (Disease Ontology:DOID:0080199); Coronavirus infectious disease (Disease Ontology:DOID:0080599); anogenital venereal wart (Disease Ontology:DOID:11168); testicular lymphoma (Disease Ontology:DOID:12253); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); hepatitis B (Disease Ontology:DOID:2043); colon adenocarcinoma (Disease Ontology:DOID:234); central nervous system lymphoma (Disease Ontology:DOID:3234); lung non-small cell carcinoma (Disease Ontology:DOID:3908); esophageal cancer (Disease Ontology:DOID:5041); primary immunodeficiency disease (Disease Ontology:DOID:612); hepatocellular carcinoma (Disease Ontology:DOID:684); monoclonal gammopathy of uncertain significance (Disease Ontology:DOID:7442); colorectal cancer (Disease Ontology:DOID:9256); pyogenic bacterial infections due to MyD88 deficiency (MONDO:MONDO:0012839)",
        "pathway": " (hsa:4615);  (R-HSA-1236974);  (R-HSA-1257604);  (R-HSA-166058);  (R-HSA-1810476);  (R-HSA-209543);  (R-HSA-3134963);  (R-HSA-5602498);  (R-HSA-5602680);  (R-HSA-5603037);  (R-HSA-5603041);  (R-HSA-6811558);  (R-HSA-9020702);  (R-HSA-975110);  (R-HSA-975138);  (R-HSA-975155);  (R-HSA-975871)",
        "pathway_count": 17,
        "publication_count": 199,
        "publication_id_list": "10075690;10191262;10465784;10514433;10702308;10723127;10747026;10854325;10882101;10918611;11073981;11094434;11147812;11237011;11244088;11487608;11544529;11803464;11960013;12138165;12140561;12167717;12221085;12297423;12447441;12447442;12496252;12538665;12637671;12724322;12767043;12791687;12860405;1325671;14625308;15145317;15361868;15465037;15492225;15585605;15718470;15767370;15917247;15944945;16024789;16056267;16115877;16286015;16286016;16439361;16456541;16751103;16951688;17047224;17135271;17141195;17200115;17322885;17485511;17507369;17675297;17726518;17878161;17878374;17890055;17893200;17997719;18070880;18070982;18180283;1828071;18292575;1833184;18438411;18669862;18692471;18710948;18794297;18810425;18829464;18925875;18941233;19217269;19224918;19264966;19265123;19498957;19506249;19509286;19576174;19590578;19592493;19592497;19666475;19805105;19903815;19948740;20043992;20338997;20485341;20696886;20855887;20966070;21057262;21179087;2139180;2147937;21606490;21827948;22153078;22155231;22424782;22454496;22931316;23186163;23453969;23481700;23569230;23613522;24265315;24316379;24366360;24618691;24714562;24715725;24840642;25083866;25320320;25369374;25418920;25576301;26154972;26375851;26728094;27466718;27701768;28228285;28832583;28904123;29242379;29395066;29437277;2946959;29493099;29557506;29632046;29789417;30115681;30315122;30524438;30620550;31844290;32157095;32350084;32387766;32502341;32897882;32938616;32983136;33592498;33691108;33717175;33718825;33936100;33968037;34171305;34357683;34509645;35051231;35251023;35318648;35580925;36284347;37971847;39111613;39190378;40596516;40638072;7628694;7637810;7744773;8327496;8332913;8599092;8645157;8837778;8957090;9008162;9013863;9346484;9371760;9430229;9575168;9736715;9859996;9895304;9915784;9990852;9990853",
        "class_list": "",
        "function": "Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; MiR-21 attenuated inflammation targeting MyD88 in human chondrocytes stimulated with Hyaluronan oligosaccharides., [RefSeq, PubMed]; TNFAIP3 Overexpression Inhibits Diffuse Large B-Cell Lymphoma Progression by Promoting Autophagy through TLR4/MyD88/NF-kappaB Signaling Pathway., [RefSeq, PubMed]; This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 19,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DKH8;B4DKU4;B4DQ60;B4DQ72;J3KPU4;J3KQ87;J3KQJ6;P78397;Q53XS7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0035591 signaling adaptor activity;GO:0035325 Toll-like receptor binding;GO:0005149 interleukin-1 receptor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface",
        "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0032747 positive regulation of interleukin-23 production;GO:0032740 positive regulation of interleukin-17 production;GO:0044546 NLRP3 inflammasome complex assembly;GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 20.2,
        "record_id": "Q99836-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P57682-1",
        "uniprot_id": "KLF3_HUMAN",
        "mass": 38829.0,
        "length": 345,
        "protein_name": "Krueppel-like factor 3",
        "gene_name": "KLF3",
        "organism": "Human",
        "refseq_name": "Krueppel-like factor 3",
        "refseq_ac": "NP_057615",
        "gene_names_uniprotkb": "KLF3; BKLF",
        "gene_names_refseq": "BKLF; KLF3",
        "protein_names_uniprotkb": "Krueppel-like factor 3; Basic krueppel-like factor; CACCC-box-binding protein BKLF; TEF-2",
        "protein_names_refseq": "CACCC-box-binding protein BKLF; Krueppel-like factor 3; Kruppel like factor 3; Kruppel-like factor 3 (basic); TEF-2; basic Kruppel-like factor; basic krueppel-like factor; basic kruppel like factor; transcript ch138",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51274)",
        "pathway_count": 1,
        "publication_count": 55,
        "publication_id_list": "12812068;15684403;17081983;18452278;18669648;19413330;19651622;20068231;23186163;25218447;25576301;25645385;25892735;26154972;26992070;28832583;28904123;29242379;29485866;29493099;29557506;29632046;29632711;29769354;29786170;30410026;30429286;30779550;31154438;31222486;31375868;31844290;31848261;32157095;32161166;32897882;32938616;32983136;33123756;33592498;33968037;33981976;34087483;34171305;34185709;34932366;35051231;35318648;35580925;36241641;36827869;37597242;37600783;37945021;38073441",
        "class_list": "",
        "function": "Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity)., [UniProtKB]; Decreased KLF3 Expression via miR-660-5p Targeting Suppresses Gastric Cancer Cell Progression., [RefSeq, PubMed]; KLF3 Transcription Activates WNT1 and Promotes the Growth and Metastasis of Gastric Cancer via Activation of the WNT/beta-Catenin Signaling Pathway., [RefSeq, PubMed]; MicroRNA-92b-3p augments colon cancer development through inhibiting KLF3., [RefSeq, PubMed]; Molecular Expression and Prognostic Implications of Kruppel-Like Factor 3 (KLF3) in Clear Cell Renal Cell Carcinoma., [RefSeq, PubMed]; Pan-cancer analysis of Kruppel-like factor 3 and its carcinogenesis in pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The recruitment of CtBP and sumoylation are required for full repression by BKLF., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6PIR1;Q86TN0;Q9P2X6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:1990859 cellular response to endothelin;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030097 hemopoiesis",
        "synthesized_glycan_count": 0,
        "hit_score": 5.8,
        "record_id": "P57682-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BYS1-1",
        "uniprot_id": "KRA15_HUMAN",
        "mass": 18010.0,
        "length": 174,
        "protein_name": "Keratin-associated protein 1-5",
        "gene_name": "KRTAP1-5",
        "organism": "Human",
        "refseq_name": "keratin-associated protein 1-5",
        "refseq_ac": "NP_114163",
        "gene_names_uniprotkb": "KRTAP1-5; KAP1.5; KRTAP1.5",
        "gene_names_refseq": "KAP1.5; KRTAP1-5; KRTAP1.5",
        "protein_names_uniprotkb": "Keratin-associated protein 1-5; High sulfur keratin-associated protein 1.5; Keratin-associated protein 1.5",
        "protein_names_refseq": "high sulfur keratin-associated protein 1.5; keratin associated protein 1.5; keratin-associated protein 1-5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:83895);  (R-HSA-6805567)",
        "pathway_count": 2,
        "publication_count": 12,
        "publication_id_list": "11279113;12228244;15373777;16382671;1691188;1694855;1714783;17521629;23481192;2414304;25208914;9468612",
        "class_list": "",
        "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]; No polymorphic alleles were found for the hKAP1.4 and hKAP1.5 genes in Japanese and Caucasian individuals, [RefSeq, PubMed]; This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NJW6;A6NLZ6;B6ZDR1;Q52LP6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q9BYS1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y4D2-1",
        "uniprot_id": "DGLA_HUMAN",
        "mass": 114952.0,
        "length": 1042,
        "protein_name": "Diacylglycerol lipase-alpha",
        "gene_name": "DAGLA",
        "organism": "Human",
        "refseq_name": "diacylglycerol lipase-alpha",
        "refseq_ac": "NP_006124",
        "gene_names_uniprotkb": "DAGLA; C11orf11; KIAA0659; NSDDR",
        "gene_names_refseq": "C11orf11; DAGL(ALPHA); DAGLALPHA; DAGLA; NOC2; NSDDR",
        "protein_names_uniprotkb": "Diacylglycerol lipase-alpha; 3.1.1.116; DAGL-alpha; DGL-alpha; Neural stem cell-derived dendrite regulator; Sn1-specific diacylglycerol lipase alpha",
        "protein_names_refseq": "DAGL-alpha; DGL-alpha; diacylglycerol lipase-alpha; neural stem cell-derived dendrite regulator; sn1-specific diacylglycerol lipase alpha",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); spinocerebellar ataxia 20 (Disease Ontology:DOID:0050971); lung cancer (Disease Ontology:DOID:1324); alcohol use disorder (Disease Ontology:DOID:1574); cocaine dependence (Disease Ontology:DOID:9975); benign paroxysmal tonic upgaze of childhood with ataxia (MONDO:MONDO:0008206)",
        "pathway": " (hsa:747);  (R-HSA-426048)",
        "pathway_count": 2,
        "publication_count": 26,
        "publication_id_list": "10348910;11237011;14610053;16051747;18096503;18801880;19126434;21418147;22969151;23502535;26668358;27595600;29145497;29477030;29614312;30429286;32387766;32983136;33592498;33968037;35051231;35580925;35737950;36215666;37414748;7295321",
        "class_list": "",
        "function": "Diacylglycerol lipase alpha promotes hepatocellular carcinoma progression and induces lenvatinib resistance by enhancing YAP activity. Publication Status: Online-Only, [RefSeq, PubMed]; Our findings indicated the involvement of DAGLA in alcoholism, possibly by its genetic dysfunction and also by the influence of stress, [RefSeq, PubMed]; Overexpression of DAGLA in human oral squamous cell carcinomas cells controlled cell proliferation through cell-cycle progression., [RefSeq, PubMed]; Phenotypes associated with rare CNR1 variants are reminiscent of those implicated in the theory of clinical endocannabinoid deficiency syndrome. The severe phenotypes associated with rare DAGLA variants underscore the critical role of rapid 2-AG synthesis and the endocannabinoid system in regulating neurological function and development Publication Status: Online-Only, [RefSeq, PubMed]; Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:23502535, PubMed:26668358). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:23502535, PubMed:26668358). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Also regulates neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]., [RefSeq]; This gene was functionally characterized as a diacylglycerol-lipase (DAGL), specifically referred to as DAGL alpha.  This enzyme may play a role in the biosynthesis of the endocannbinoid 2-arachidonoylglycerol (2-AG)., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 12,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 6,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A024R517;A7E233;Q6WQJ0",
        "ec_number_list": "3.1.1.32;3.1.1.3;3.1.1.5;3.1.1.116",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0047372 monoacylglycerol lipase activity;GO:0004465 lipoprotein lipase activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0031901 early endosome membrane;GO:0032590 dendrite membrane;GO:0043196 varicosity",
        "go_biological_process": "GO:0098921 retrograde trans-synaptic signaling by endocannabinoid;GO:0045471 response to ethanol;GO:0046340 diacylglycerol catabolic process;GO:0022008 neurogenesis;GO:0019369 arachidonate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "Q9Y4D2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y250-1",
        "uniprot_id": "LZTS1_HUMAN",
        "mass": 66613.0,
        "length": 596,
        "protein_name": "Leucine zipper putative tumor suppressor 1",
        "gene_name": "LZTS1",
        "organism": "Human",
        "refseq_name": "leucine zipper putative tumor suppressor 1",
        "refseq_ac": "NP_066300",
        "gene_names_uniprotkb": "LZTS1; FEZ1",
        "gene_names_refseq": "F37; FEZ1; LZTS1",
        "protein_names_uniprotkb": "Leucine zipper putative tumor suppressor 1; F37/esophageal cancer-related gene-coding leucine-zipper motif; Fez1",
        "protein_names_refseq": "F37/Esophageal cancer-related gene-coding leucine-zipper motif; leucine zipper putative tumor suppressor 1; leucine zipper, putative tumor suppressor 1",
        "tax_id": 9606,
        "disease": "squamous cell carcinoma (Disease Ontology:DOID:1749); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); esophageal cancer (Disease Ontology:DOID:5041)",
        "pathway": " (hsa:11178)",
        "pathway_count": 1,
        "publication_count": 29,
        "publication_id_list": "10097140;11464283;11504921;12377406;12851677;16484223;22299025;22424782;25576301;25645385;25938461;26504261;26653561;26992070;29242379;29557506;29769354;30429286;30568303;31844290;32157095;32387766;32488085;32983136;33592498;36010968;37217939;39023696;39039081",
        "class_list": "",
        "function": "Compared with the normal hepatocyte cells, LZTS1 expression in hepatocellular carcinoma cells was significantly lower, [RefSeq, PubMed]; Down-regulation of FEZ1/LZTS1 gene with frequent loss of heterozygosity is associated with oral squamous cell carcinomas, [RefSeq, PubMed]; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor., [UniProtKB, PubMed, PubMed, PubMed]; MiR-135b expression inversely correlated with LZTS1 staining intensity and the Cutaneous Squamous Cell Carcinoma grade. Publication Status: Online-Only, [RefSeq, PubMed]; Missense variant in the LZTS1 gene was identified in two Ehlers-Danlos syndrome patients in an extended family., [RefSeq, PubMed]; This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]., [RefSeq]; Unveiling the oncogenic role of LZTS1 in colorectal cancer., [RefSeq, PubMed]; Variation in the germline sequence is associated with prostate cancer risk GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DSQ6;Q9Y5V7;Q9Y5V8;Q9Y5V9;Q9Y5W0;Q9Y5W1;Q9Y5W2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine",
        "go_biological_process": "GO:0048814 regulation of dendrite morphogenesis;GO:0048167 regulation of synaptic plasticity;GO:0016242 negative regulation of macroautophagy;GO:0150052 regulation of postsynapse assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q9Y250-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q15849-1",
        "uniprot_id": "UT2_HUMAN",
        "mass": 101209.0,
        "length": 920,
        "protein_name": "Urea transporter 2",
        "gene_name": "SLC14A2",
        "organism": "Human",
        "refseq_name": "urea transporter 2",
        "refseq_ac": "NP_001229621",
        "gene_names_uniprotkb": "SLC14A2; HUT2; UT2",
        "gene_names_refseq": "HUT2; SLC14A2; UT-A2; UT2; UTA; UTR; hUT-A6",
        "protein_names_uniprotkb": "Urea transporter 2; Solute carrier family 14 member 2; Urea transporter, kidney",
        "protein_names_refseq": "solute carrier family 14 (urea transporter), member 2; urea transporter 2; urea transporter, kidney",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8170);  (R-HSA-549127)",
        "pathway_count": 2,
        "publication_count": 45,
        "publication_id_list": "10072434;10196521;10966924;11237011;11502588;12089149;12372408;12384147;14608356;14674884;15107849;15184985;15795384;16330770;16788146;16807400;17509534;17702749;23481700;25298340;25298341;25418920;25892735;26522469;26927669;28218747;28904123;29242379;29279852;29437277;29493099;30315122;32938616;33912179;34357683;35051231;36010968;7989337;8647271;8997401;9260930;9520460;9655880;9685390;9744804",
        "class_list": "",
        "function": "Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism., [UniProtKB, PubMed, PubMed]; Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism., [UniProtKB, PubMed, PubMed]; Studies indicate that osmotic diuresis, where urea concentrations are low, can prompt an increase in urea transporter abundance. Review article, [RefSeq, PubMed]; Studies indicate that the cell signaling pathway for vasopressin-mediated urea transporters phosphorylation and activity involves two cAMP-dependent signaling pathways. Review article, [RefSeq, PubMed]; The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]., [RefSeq]; The urea transporter subtypes, UT-A1 and UT-B1, were expressed in the skin basal cell layer and exocrine sweat glands. The abundance of UT-A1 and UT-B1 in uremic sweat glands was significantly increased in UP, while the expression of AQP5 was decreased., [RefSeq, PubMed]; UT2 is a negative regulator shared across STAT3 and mTORC2 signaling cascades, functioning as a tumor suppressor in hematologic malignancies driven by those pathways., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K8Q7;Q2TBD6;Q96PH5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0015204 urea transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0071918 urea transmembrane transport;GO:0015837 amine transport;GO:0015840 urea transport",
        "synthesized_glycan_count": 0,
        "hit_score": 4.6,
        "record_id": "Q15849-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NVP1-1",
        "uniprot_id": "DDX18_HUMAN",
        "mass": 75407.0,
        "length": 670,
        "protein_name": "ATP-dependent RNA helicase DDX18",
        "gene_name": "DDX18",
        "organism": "Human",
        "refseq_name": "ATP-dependent RNA helicase DDX18",
        "refseq_ac": "NP_006764",
        "gene_names_uniprotkb": "DDX18; cPERP-D",
        "gene_names_refseq": "DDX18; Has1; MrDb",
        "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX18; 3.6.4.13; DEAD box protein 18; MrDb; Myc-regulated DEAD box protein",
        "protein_names_refseq": "ATP-dependent RNA helicase DDX18; DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; DEAD box protein 18; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 18 (Myc-regulated); Helicase Associated with Set1 homolog; Myc-regulated DEAD box protein",
        "tax_id": 9606,
        "disease": "sinusitis (Disease Ontology:DOID:0050127); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); obstructive sleep apnea (Disease Ontology:DOID:0050848); stroke (Disease Ontology:DOID:0051061); withdrawal disorder (Disease Ontology:DOID:0060001); lupus nephritis (Disease Ontology:DOID:0080162); nephrotic syndrome type 2 (Disease Ontology:DOID:0080379); graft-versus-host disease (Disease Ontology:DOID:0081267); traumatic brain injury (Disease Ontology:DOID:0081292); hypertension (Disease Ontology:DOID:10763); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); lipoid nephrosis (Disease Ontology:DOID:10966); opioid abuse (Disease Ontology:DOID:11206); polycystic ovary syndrome (Disease Ontology:DOID:11612); nephrotic syndrome (Disease Ontology:DOID:1184); primary biliary cholangitis (Disease Ontology:DOID:12236); uveitis (Disease Ontology:DOID:13141); pulmonary sarcoidosis (Disease Ontology:DOID:13406); alcoholic neuropathy (Disease Ontology:DOID:14183); generalized anxiety disorder (Disease Ontology:DOID:14320); major depressive disorder (Disease Ontology:DOID:1470); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); post-traumatic stress disorder (Disease Ontology:DOID:2055); brain ischemia (Disease Ontology:DOID:2316); morphine dependence (Disease Ontology:DOID:2560); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); mood disorder (Disease Ontology:DOID:3324); coronary artery disease (Disease Ontology:DOID:3393); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); primary hyperaldosteronism (Disease Ontology:DOID:446); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); muscular atrophy (Disease Ontology:DOID:767); end stage renal disease (Disease Ontology:DOID:783); cocaine abuse (Disease Ontology:DOID:809); cataract (Disease Ontology:DOID:83); lung disease (Disease Ontology:DOID:850); anorexia nervosa (Disease Ontology:DOID:8689); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)",
        "pathway": " (hsa:8886)",
        "pathway_count": 1,
        "publication_count": 102,
        "publication_id_list": "11237011;12665801;16150497;16959974;16963496;18077418;18351129;18491316;18991276;19608861;20068231;20813266;20934997;20941364;23481700;24366607;24715725;25284587;25418920;25576301;25645385;26154972;26992070;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29314611;29393594;29437277;29493099;29508533;29557506;29605689;29632046;29632711;29769354;29786170;30315122;30410026;30429286;30484775;30833945;31154438;31530632;31844290;31848261;31937595;31998317;32119511;32157095;32350084;32357974;32387766;32502341;32522876;32870666;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33633747;33717175;33912179;33936100;33968037;34019948;34087483;34171305;34229054;34357683;34509645;34561969;34725712;34932366;35051231;35083852;35251023;35494241;35561310;35580925;35858569;36241641;36284347;36976498;37217939;37938771;38665916;38732173;40914422;8861962",
        "class_list": "",
        "function": "ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the formation of R-loop during transcription and prevent the interference of R-loop with DNA-replication machinery. Also participates in the removal of DNA-lesion-associated R-loop (PubMed:35858569). Plays an essential role for establishing pluripotency during embryogenesis and for pluripotency maintenance in embryonic stem cells. Mechanistically, prevents the polycomb repressive complex 2 (PRC2) from accessing rDNA loci and protects the active chromatin status in nucleolus (By similarity)., [UniProtKB, UniProtKB, PubMed]; DDX18 Facilitates the Tumorigenesis of Lung Adenocarcinoma by Promoting Cell Cycle Progression through the Upregulation of CDK4. Publication Status: Online-Only, [RefSeq, PubMed]; DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein. [provided by RefSeq, Jul 2008]., [RefSeq]; DNA 6mA demethylase ALKBH1 regulates DDX18 expression to promote proliferation of human head and neck squamous cell carcinoma., [RefSeq, PubMed]; Data show that odulation of RNA helicase DDX18 directly affects growth of tamoxifen-resistant cells, suggesting that it may be a critical downstream effector of the estrogen receptors (ERs) and high mobility group box 2 (HMGB2) complex., [RefSeq, PubMed]; Findings suggest that MrDb is important for cell proliferation and that its inhibition could prevent tumor cell proliferation., [RefSeq, PubMed]; RNA helicase., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 50,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6GTZ9;Q6IAU4;Q92732;Q9BQB7",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0016020 membrane;GO:0005694 chromosome",
        "go_biological_process": "GO:0071392 cellular response to estradiol stimulus;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)",
        "synthesized_glycan_count": 0,
        "hit_score": 10.5,
        "record_id": "Q9NVP1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BS40-1",
        "uniprot_id": "LXN_HUMAN",
        "mass": 25750.0,
        "length": 222,
        "protein_name": "Latexin",
        "gene_name": "LXN",
        "organism": "Human",
        "refseq_name": "latexin",
        "refseq_ac": "NP_064554",
        "gene_names_uniprotkb": "LXN",
        "gene_names_refseq": "ECI; LXN; TCI",
        "protein_names_uniprotkb": "Latexin; ECI; Endogenous carboxypeptidase inhibitor; Protein MUM; TCI; Tissue carboxypeptidase inhibitor",
        "protein_names_refseq": "MUM; endogenous carboxypeptidase inhibitor; latexin; tissue carboxypeptidase inhibitor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:56925)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;11455960;15738388;21466706;21567403;23028717;28087740;28510447;29608488;30914656;31844290;36284347;36949500;38665916",
        "class_list": "",
        "function": "Circ_0002715 promotes the development of osteoarthritis through regulating LXN by sponging miR-127-5p. Publication Status: Online-Only, [RefSeq, PubMed]; Deletion of latexin in vivo increases HSC repopulation capacity and survival, expands the entire hematopoietic system, and mitigates myelosuppression. Latexin inactivation downregulates thrombospondin 1 (Thbs1). It inhibits nuclear translocation of ribosomal protein subunit 3 (Rps3), a novel latexin-binding protein, and sensitizes hematopoietic cells to radiation-induced cell death. Review article, [RefSeq, PubMed]; Downregulated expression in gastric carcinomas; tumor suppressor Publication Status: Online-Only, [RefSeq, PubMed]; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation., [UniProtKB, PubMed]; Latexin expression is lost or greatly reduced in approximately 50% of human leukemia/lymphoma cell lines., [RefSeq, PubMed]; Results identified that LXN expression inversely modulates taxane-chemoresistance in the PC-3 prostate cancer cell line. Inhibition of LXN expression in the bone microenvironment promotes chemoresistance, in part through a methylation-dependent mechanism., [RefSeq, PubMed]; The putative tumour suppressor protein Latexin is secreted by prostate luminal cells and is downregulated in malignancy. Publication Status: Online-Only, [RefSeq, PubMed]; These results are consistent with a tumor suppressor role for latexin., [RefSeq, PubMed]; This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. The encoded protein, latexin, downregulates the population size of hematopoietic stem cells. This protein is found to be downregulated in cancer cells because of promoter hypermethylation. [provided by RefSeq, Jul 2020]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96PN2;Q9NQS6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008201 heparin binding;GO:0008191 metalloendopeptidase inhibitor activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006954 inflammatory response",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q9BS40-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96HR3-1",
        "uniprot_id": "MED30_HUMAN",
        "mass": 20277.0,
        "length": 178,
        "protein_name": "Mediator of RNA polymerase II transcription subunit 30",
        "gene_name": "MED30",
        "organism": "Human",
        "refseq_name": "mediator of RNA polymerase II transcription subunit 30 isoform 2",
        "refseq_ac": "NP_001269915",
        "gene_names_uniprotkb": "MED30; THRAP6; TRAP25",
        "gene_names_refseq": "MED30S; MED30; THRAP6; TRAP25",
        "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 30; Mediator complex subunit 30; TRAP/Mediator complex component TRAP25; Thyroid hormone receptor-associated protein 6; Thyroid hormone receptor-associated protein complex 25 kDa component; Trap25",
        "protein_names_refseq": "TRAP/Mediator complex component TRAP25; mediator of RNA polymerase II transcription subunit 30 isoform 2; mediator of RNA polymerase II transcription subunit 30; putative mediator of RNA polymerase II transcription subunit 30; thyroid hormone receptor-associated protein 6; thyroid hormone receptor-associated protein complex 25 kDa component",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:90390);  (R-HSA-1989781);  (R-HSA-212436);  (R-HSA-381340);  (R-HSA-9833110);  (R-HSA-9841922)",
        "pathway_count": 6,
        "publication_count": 132,
        "publication_id_list": "10075656;10235266;10330177;10425206;10558993;10777541;10835357;10882139;11027271;11095972;11267664;11395415;11607032;11872672;11909976;12118000;12177166;12213831;12505311;12582161;12584197;12829629;1310260;14519192;14976261;15067378;15130092;15175151;15175163;15273253;15635043;15850785;15896744;15919796;15989967;16380219;16595664;16606702;16719718;16972786;17011499;17761950;17980149;18420935;18540824;18691976;18719978;18848529;18931025;19043829;19088433;19115207;19172745;19413330;19710929;19934321;20068231;20101261;20110263;20410276;2163759;22090124;23239344;23301498;23481700;24196956;24714562;25418920;25576301;25854864;26375851;26728094;26811146;26992070;27862975;27920218;28063628;28832583;28904123;29242379;29331515;29393594;29508533;29557506;29632046;29786170;30429286;30524438;31844290;32157095;32265295;32357974;32387766;32502341;32705436;32897882;32938616;32983136;33329381;33592498;33912179;33968037;34019948;34509645;34561969;35051231;35318648;35580925;36010968;36102648;37938771;7685352;7892212;8183939;8325954;8521497;8521498;8643605;8647822;8706692;8769649;8770873;8970730;9012850;9065481;9171241;9454824;9637681;9653119;9744270;9748239;9836620",
        "class_list": "",
        "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, PubMed, PubMed]; HIF1alpha and p53 Regulated MED30, a Mediator Complex Subunit, is Involved in Regulation of Glioblastoma Pathogenesis and Temozolomide Resistance., [RefSeq, PubMed]; The multiprotein TRAP/Mediator complex facilitates gene expression through a wide variety of transcriptional activators. MED30 is a component of this complex that appears to be metazoan specific (Baek et al., 2002 [PubMed 11909976]).[supplied by OMIM, Nov 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C6GKU9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0061630 ubiquitin protein ligase activity;GO:0046966 nuclear thyroid hormone receptor binding;GO:0003712 transcription coregulator activity;GO:0042809 nuclear vitamin D receptor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000151 ubiquitin ligase complex;GO:0016592 mediator complex",
        "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 13.5,
        "record_id": "Q96HR3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P56597-1",
        "uniprot_id": "NDK5_HUMAN",
        "mass": 24236.0,
        "length": 212,
        "protein_name": "Nucleoside diphosphate kinase 5",
        "gene_name": "NME5",
        "organism": "Human",
        "refseq_name": "nucleoside diphosphate kinase 5",
        "refseq_ac": "NP_003542",
        "gene_names_uniprotkb": "NME5; RSPH23",
        "gene_names_refseq": "CILD48; NDK5; NM23-H5; NM23H5; NME5; RSPH23",
        "protein_names_uniprotkb": "Nucleoside diphosphate kinase 5; 3.1.11.-; IPIA-beta; Inhibitor of p53-induced apoptosis-beta; NDK5; Putative 3'-5'-DNA exonuclease NDK5; Radial spoke head protein 23 homolog; Testis-specific nm23 homolog; nm23-H5",
        "protein_names_refseq": "3'-5' exonuclease NME5; IPIA-beta; NDK-H 5; NDP kinase homolog 5; inhibitor of p53-induced apoptosis-beta; non-metastatic cells 5 protein expressed in; non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase); nucleoside diphosphate kinase 5; nucleoside diphosphate kinase homolog 5; putative 3'-5'-DNA exonuclease NDK5; radial spoke 23 homolog; radial spoke head protein 23 homolog; testis-specific nm23 homolog",
        "tax_id": 9606,
        "disease": "hydrocephalus (Disease Ontology:DOID:10908); primary ciliary dyskinesia (Disease Ontology:DOID:9562); ciliary dyskinesia, primary, 48, without situs inversus (MONDO:MONDO:0031054)",
        "pathway": " (hsa:8382)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "14499630;16313181;18083107;27600516;30429286;31154438;32185794;32950024;35051231;36215666;9742940",
        "class_list": "",
        "function": "A nonsense variant in NME5 causes human primary ciliary dyskinesia with radial spoke defects., [RefSeq, PubMed]; Found that Nm23-H5 and NDP kinases A and B are differently distributed in spermatids and mature spermatozoa and could therefore be involved at various levels of sperm differentiation and function, [RefSeq, PubMed]; Functions as part of axonemal radial spoke complexes, which play an important part in the motility of sperm and cilia (By similarity). In vitro, does not display nucleoside diphosphate kinase (NDPK) activity (Probable) (PubMed:16313181, PubMed:9742940). Exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, possibly participating in DNA nucleolytic processing (PubMed:16313181). Confers protection from cell death mediated by BAX and alters the cellular levels of several antioxidant enzymes, including GPX5 (By similarity). Might be involved in spermiogenesis by enhancing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5G7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity",
        "go_cellular_component": "GO:0001534 radial spoke;GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0097729 9+2 motile cilium",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0007286 spermatid development;GO:0009116 nucleoside metabolic process;GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "P56597-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BQS6-1",
        "uniprot_id": "HSPB9_HUMAN",
        "mass": 17486.0,
        "length": 159,
        "protein_name": "Heat shock protein beta-9",
        "gene_name": "HSPB9",
        "organism": "Human",
        "refseq_name": "heat shock protein beta-9",
        "refseq_ac": "NP_149971",
        "gene_names_uniprotkb": "HSPB9",
        "gene_names_refseq": "CT51; HSPB9",
        "protein_names_uniprotkb": "Heat shock protein beta-9; CT51; Cancer/testis antigen 51; Heat shock protein family B member 9; HspB9",
        "protein_names_refseq": "cancer/testis antigen 51; heat shock protein beta-9; heat shock protein family B member 9; heat shock protein, alpha-crystallin-related, B9; small heat shock protein B9",
        "tax_id": 9606,
        "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)",
        "pathway": " (hsa:94086)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "11470154;19464326;32488085",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KSG6;Q52LB4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q9BQS6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NPL8-1",
        "uniprot_id": "TIDC1_HUMAN",
        "mass": 32178.0,
        "length": 285,
        "protein_name": "Complex I assembly factor TIMMDC1, mitochondrial",
        "gene_name": "TIMMDC1",
        "organism": "Human",
        "refseq_name": "complex I assembly factor TIMMDC1, mitochondrial isoform 1 precursor",
        "refseq_ac": "NP_057673",
        "gene_names_uniprotkb": "TIMMDC1; C3orf1; PRO284",
        "gene_names_refseq": "C3orf1; MC1DN31; TIMMDC1",
        "protein_names_uniprotkb": "Complex I assembly factor TIMMDC1, mitochondrial; Protein M5-14; TIMM domain containing protein 1; Translocase of inner mitochondrial membrane domain-containing protein 1",
        "protein_names_refseq": "M5-14 protein; TIMM domain containing-protein 1; complex I assembly factor TIMMDC1, mitochondrial isoform 1 precursor; complex I assembly factor TIMMDC1, mitochondrial; translocase of inner mitochondrial membrane domain-containing protein 1; transmembrane protein C3orf1",
        "tax_id": 9606,
        "disease": "nuclear type mitochondrial complex I deficiency 31 (Disease Ontology:DOID:0112071)",
        "pathway": " (hsa:51300);  (R-HSA-6799198)",
        "pathway_count": 2,
        "publication_count": 89,
        "publication_id_list": "11092749;11220739;11230166;11237011;12975309;17936786;19664994;19752196;20406883;20552642;20858599;21924235;23553477;24191001;24275569;24715725;25418920;25576301;25645385;25678554;26154972;26992070;27452731;27499296;27600516;27626371;28218747;28228285;28604674;28832583;29242379;29331515;29393594;29437277;29557506;29632046;29786170;29789417;30315122;30429286;30524438;31154438;31217245;31222486;31324691;31666358;31717259;31844290;31848261;31866046;31937595;32157095;32161166;32320651;32350084;32357974;32387766;32488085;32502341;32897882;32938616;33043033;33141586;33278652;33537174;33592498;33691108;33852835;33879611;33882309;33912179;33936100;33968037;34087483;34185709;34357683;34561969;35051231;35251023;35318648;35333655;35580925;35614220;36010968;36215666;36241641;37938771;38199007;9571201",
        "class_list": "",
        "function": "A membrane arm of mitochondrial complex I sufficient to promote respirasome formation., [RefSeq, PubMed]; Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Deep intronic TIMMDC1 variant delays diagnosis of rapidly progressive complex I deficiency., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DN81;Q6IAJ7;Q6UWU6;Q9NPR3;Q9NPS5;Q9P0Y6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 9.0,
        "record_id": "Q9NPL8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14674-1",
        "uniprot_id": "ESPL1_HUMAN",
        "mass": 233175.0,
        "length": 2120,
        "protein_name": "Separin",
        "gene_name": "ESPL1",
        "organism": "Human",
        "refseq_name": "separin",
        "refseq_ac": "NP_036423",
        "gene_names_uniprotkb": "ESPL1; ESP1; KIAA0165",
        "gene_names_refseq": "ESP1; ESPL1; SEPA",
        "protein_names_uniprotkb": "Separin; 3.4.22.49; Caspase-like protein ESPL1; Extra spindle poles-like 1 protein; Separase",
        "protein_names_refseq": "caspase-like protein ESPL1; extra spindle pole bodies 1, separase; extra spindle pole bodies homolog 1; extra spindle poles like 1; extra spindle poles-like 1 protein; separin, cysteine protease; separin",
        "tax_id": 9606,
        "disease": "breast cancer (Disease Ontology:DOID:1612)",
        "pathway": " (hsa:9700);  (R-HSA-2467813)",
        "pathway_count": 2,
        "publication_count": 91,
        "publication_id_list": "10411507;11081627;11237011;11371342;11509732;11747808;12194817;12297314;12771378;15302935;15737063;17322306;17484111;18669648;18691976;18767875;19413330;19690332;20068231;22870341;22885700;23186163;23481700;24366607;24715725;25418920;25576301;25576336;25880248;26154972;26992070;27600516;27846572;27920218;28218747;28228285;28649982;28832583;28834231;28904123;29242379;29371260;29393594;29437277;29493099;29632046;29786170;30315122;30524438;30779550;30833945;31092671;31217245;31530632;31844290;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34180834;34290405;34509645;34932366;35051231;35318648;35561310;35580925;36010968;36241641;37140261;38568742;9892021",
        "class_list": "",
        "function": "Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms., [UniProtKB, PubMed, PubMed]; Data suggest that separase is required for sister chromatid separation during mitosis in human cells, and that securin inhibits separase by blocking the access of substrates to the active site of separase., [RefSeq, PubMed]; Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]., [RefSeq]; Structural basis of human separase regulation by securin and CDK1-cyclin B1., [RefSeq, PubMed]; The molecular mechanisms of human separase regulation. Review article, [RefSeq, PubMed]; Upregulation of ESPL1 is associated with poor prognostic outcomes in endometrial cancer., [RefSeq, PubMed]; [Separase, a key-player of mitosis: A new target for cancer therapy?]', trans 'La separase, proteine-cle de la mitose - Une nouvelle cible therapeutique anti-cancereuse ?, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 13,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "3.6.5.-;2.7.11.1;3.1.3.16;2.3.2.-;2.7.11.21;3.4.22.49;3.6.4.12",
        "go_molecular_function": "GO:0003824 catalytic activity;GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol",
        "go_biological_process": "GO:0045875 negative regulation of sister chromatid cohesion;GO:0051307 meiotic chromosome separation;GO:0006508 proteolysis;GO:0006915 apoptotic process;GO:0051306 mitotic sister chromatid separation",
        "synthesized_glycan_count": 0,
        "hit_score": 9.2,
        "record_id": "Q14674-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96HI0-1",
        "uniprot_id": "SENP5_HUMAN",
        "mass": 86693.0,
        "length": 755,
        "protein_name": "Sentrin-specific protease 5",
        "gene_name": "SENP5",
        "organism": "Human",
        "refseq_name": "sentrin-specific protease 5 isoform 2",
        "refseq_ac": "NP_001294974",
        "gene_names_uniprotkb": "SENP5; FKSG45",
        "gene_names_refseq": "SENP5",
        "protein_names_uniprotkb": "Sentrin-specific protease 5; 3.4.22.-; Sentrin/SUMO-specific protease SENP5",
        "protein_names_refseq": "SUMO1/sentrin specific peptidase 5; SUMO1/sentrin specific protease 5; sentrin-specific protease 5 isoform 2; sentrin-specific protease 5; sentrin/SUMO-specific protease SENP5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:205564);  (R-HSA-3065679)",
        "pathway_count": 2,
        "publication_count": 66,
        "publication_id_list": "10806345;11237011;11896061;12192048;14563852;15487983;16253240;16608850;16738315;16738331;17591783;18949399;20068231;23481700;24397554;24714562;25406032;25418920;25576301;25645385;25880248;26288249;26728094;26811146;26992070;27600516;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29331515;29393594;29493099;29508533;29557506;29632046;30315122;30410026;30429286;31844290;31848261;32157095;32161166;32357974;32387766;32488085;32502341;32938616;32983136;33211757;33298915;33592498;33633747;33912179;33968037;34313310;35561310;35580925;36241641;37684630;39433793;39531497",
        "class_list": "",
        "function": "Altered subcellular localization of SENP5 in oral squamous cell carcinoma (OSCC) cells and the correlation between SENP5 expression and the differentiation of OSCC., [RefSeq, PubMed]; Knockdown of SENP5 resulted in increased levels of SUMO-1 and SUMO-2/3, inhibition of cell proliferation, defects in nuclear morphology, and appearance of binucleate cells, revealing an essential role for SENP5 in mitosis and/or cytokinesis., [RefSeq, PubMed]; Peptidylprolyl isomerase A guides SENP5/GAU1 DNA-lncRNA triplex generation for driving tumorigenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division., [UniProtKB, PubMed, PubMed]; Results from a study on gene expression variability markers in early-stage human embryos shows that SENP5 is a putative expression variability marker for the 3-day, 8-cell embryo stage. Publication Status: Online-Only, [RefSeq, PubMed]; SENP5 promotes homologous recombination-mediated DNA damage repair in colorectal cancer cells through H2AZ deSUMOylation. Publication Status: Online-Only, [RefSeq, PubMed]; SUMO proteases SENP3 and SENP5 spatiotemporally regulate the kinase activity of Aurora A., [RefSeq, PubMed]; The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]., [RefSeq]; Zinc deficiency induces abnormal development of the myocardium by promoting SENP5 overexpression. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DY82;Q96SA5",
        "ec_number_list": "3.4.22.-",
        "go_molecular_function": "GO:0016929 deSUMOylase activity;GO:0070139 SUMO-specific endopeptidase activity;GO:0008234 cysteine-type peptidase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0099523 presynaptic cytosol;GO:0099524 postsynaptic cytosol",
        "go_biological_process": "GO:0006508 proteolysis;GO:0016925 protein sumoylation;GO:0051301 cell division;GO:0016926 protein desumoylation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "Q96HI0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9HB65-1",
        "uniprot_id": "ELL3_HUMAN",
        "mass": 45361.0,
        "length": 397,
        "protein_name": "RNA polymerase II elongation factor ELL3",
        "gene_name": "ELL3",
        "organism": "Human",
        "refseq_name": "RNA polymerase II elongation factor ELL3",
        "refseq_ac": "NP_079441",
        "gene_names_uniprotkb": "ELL3",
        "gene_names_refseq": "ELL3",
        "protein_names_uniprotkb": "RNA polymerase II elongation factor ELL3",
        "protein_names_refseq": "RNA polymerase II elongation factor ELL3; elongation factor RNA polymerase II-like 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80237);  (R-HSA-6807505)",
        "pathway_count": 2,
        "publication_count": 68,
        "publication_id_list": "10022900;10882741;11237011;11856838;12414730;12574128;14701755;1535687;16239144;16308568;16901896;1739980;18079403;1829677;19667075;20457598;2125285;21872626;22137580;22195968;22231121;22252320;22441827;22895430;23166507;23850691;23932780;24097444;24270878;24997600;25418920;25675981;26811146;26992070;27862975;27920218;28218747;28514659;28832583;28858629;28904123;29242379;29437277;2944599;29557506;29632046;29789417;30315122;30524438;30654843;31217245;31844290;32357974;32897882;33392160;33912179;34171305;7715707;8253082;8339931;8628262;8668525;9009278;9153304;9188510;9407024;9705341;9832505",
        "class_list": "",
        "function": "Ell3 may play a critical role in promoting oncogenesis in breast cancer by regulating cell proliferation and cancer stem cell properties via the ERK1/2 signaling pathway, [RefSeq, PubMed]; Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968)., [UniProtKB, PubMed, PubMed]; Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival, [RefSeq, PubMed]; Suppression of Ell3 expression induced senescence in stem cells by increasing Bcl-2 expression. Unlike the effect of Ell3 suppression, the ectopic expression of Ell3 induces apoptosis of stem cells and induces apoptosis of adjacent cells. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KQ66;B3KX08;Q6I9Z7;Q9H634",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000987 cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0008023 transcription elongation factor complex",
        "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:1905382 positive regulation of snRNA transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048863 stem cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "Q9HB65-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q56NI9-1",
        "uniprot_id": "ESCO2_HUMAN",
        "mass": 68307.0,
        "length": 601,
        "protein_name": "N-acetyltransferase ESCO2",
        "gene_name": "ESCO2",
        "organism": "Human",
        "refseq_name": "N-acetyltransferase ESCO2",
        "refseq_ac": "NP_001017420",
        "gene_names_uniprotkb": "ESCO2",
        "gene_names_refseq": "2410004I17Rik; EFO2p; EFO2; ESCO2; JHS; RBS; hEFO2",
        "protein_names_uniprotkb": "N-acetyltransferase ESCO2; 2.3.1.-; ECO1 homolog 2; EFO2p; EFO2; Establishment factor-like protein 2; Establishment of cohesion 1 homolog 2; hEFO2",
        "protein_names_refseq": "ECO1 homolog 2; N-acetyltransferase ESCO2; establishment factor-like protein 2",
        "tax_id": 9606,
        "disease": "lung cancer (Disease Ontology:DOID:1324); lung adenocarcinoma (Disease Ontology:DOID:3910); Roberts syndrome (Disease Ontology:DOID:5325); rheumatoid arthritis (Disease Ontology:DOID:7148); Juberg-Hayward syndrome (MONDO:MONDO:0008992)",
        "pathway": " (hsa:157570);  (R-HSA-2468052)",
        "pathway_count": 2,
        "publication_count": 84,
        "publication_id_list": "11237011;15821733;15837422;15958495;16380922;17081983;18220336;18411254;18614053;18669648;19413330;19664995;19907496;20068231;21111234;22101327;22885700;23186163;23481700;24397554;24714562;24715725;25418920;25576301;26154972;26811146;26929215;26992070;27846572;27862975;27920218;28218747;28228285;28832583;28904123;29242379;29393594;29437277;29493099;29557506;29632046;30315122;30779550;30833945;31217245;31530632;31844290;31937595;32157095;32161166;32255174;32357974;32387766;32488085;32502341;32897882;32938616;32977150;33141586;33298915;33592498;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34405274;34509645;34932366;35051231;35258173;35561310;35580925;36010968;36104638;36215666;36241641;36912084;37074911;37715994;38605349;8291532",
        "class_list": "",
        "function": "Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Circular RNA METTL15/miR-374a-5p/ESCO2 axis induces colorectal cancer development., [RefSeq, PubMed]; EFO1 and EFO2 are targeted to different chromosome structures to help establish or maintain sister-chromatid cohesion, [RefSeq, PubMed]; ESCO2's oncogenic role in human tumors: a pan-cancer analysis and experimental validation. Publication Status: Online-Only, [RefSeq, PubMed]; Long noncoding RNA ZFPM2-AS1 regulates renal cell carcinoma progression via miR-130a-3p/ESCO2., [RefSeq, PubMed]; Required for the establishment of sister chromatid cohesion during S phase, [RefSeq, PubMed]; Symmetric control of sister chromatid cohesion establishment., [RefSeq, PubMed]; This gene encodes a protein that may have acetyltransferase activity and may be required for the establishment of sister chromatid cohesion during the S phase of mitosis. Mutations in this gene have been associated with Roberts syndrome. [provided by RefSeq, Jul 2008]., [RefSeq]; Upregulation of KAT2B and ESCO2 gene expression level in patients with rheumatoid arthritis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 9641,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 5,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KW59;Q49AP4",
        "ec_number_list": "2.3.1.48;2.3.1.-;2.7.11.1;2.3.1.57;2.3.1.259;2.3.1.80",
        "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0008270 zinc ion binding;GO:0016407 acetyltransferase activity;GO:0004468 L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor;GO:0008080 N-acetyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0035861 site of double-strand break;GO:0005694 chromosome",
        "go_biological_process": "GO:0006275 regulation of DNA replication;GO:0007064 mitotic sister chromatid cohesion;GO:0007062 sister chromatid cohesion;GO:0034421 post-translational protein acetylation",
        "synthesized_glycan_count": 0,
        "hit_score": 9.0,
        "record_id": "Q56NI9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0C5J1-1",
        "uniprot_id": "F86B2_HUMAN",
        "mass": 36771.0,
        "length": 330,
        "protein_name": "Putative protein N-methyltransferase FAM86B2",
        "gene_name": "FAM86B1; FAM86B2",
        "organism": "Human",
        "refseq_name": "putative protein N-methyltransferase FAM86B2",
        "refseq_ac": "NP_001131082",
        "gene_names_uniprotkb": "FAM86B1; FAM86B2; FAM86B1; FAM86B2",
        "gene_names_refseq": "FAM86B2",
        "protein_names_uniprotkb": "Putative protein N-methyltransferase FAM86B2; 2.1.1.-",
        "protein_names_refseq": "protein FAM86B2; putative protein N-methyltransferase FAM86B2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:653333)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11237011;19718026;23349634;25418920;26992070;28510447;31844290;33298915;33592498;33717175;33936100;34171305;35051231",
        "class_list": "",
        "function": "Identifies FAM86B2 as being one of 30 genes with the most variable copy numbers in three human genomes., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0016279 protein-lysine N-methyltransferase activity;GO:0008168 methyltransferase activity",
        "go_cellular_component": "GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0032259 methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "P0C5J1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15360-1",
        "uniprot_id": "FANCA_HUMAN",
        "mass": 162775.0,
        "length": 1455,
        "protein_name": "Fanconi anemia group A protein",
        "gene_name": "FANCA",
        "organism": "Human",
        "refseq_name": "Fanconi anemia group A protein isoform a",
        "refseq_ac": "NP_000126",
        "gene_names_uniprotkb": "FANCA; FAA; FACA; FANCH",
        "gene_names_refseq": "FA-H; FA1; FAA; FACA; FAH; FANCA; FANCH; FA",
        "protein_names_uniprotkb": "Fanconi anemia group A protein; Protein FACA",
        "protein_names_refseq": "Fanconi anemia complementation group A; Fanconi anemia group A protein isoform a; Fanconi anemia, complementation group H; Fanconi anemia, type 1; fanconi anemia group A protein",
        "tax_id": 9606,
        "disease": "Fanconi anemia complementation group A (Disease Ontology:DOID:0111095); urinary bladder cancer (Disease Ontology:DOID:11054); Fanconi anemia (Disease Ontology:DOID:13636); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); cervical cancer (Disease Ontology:DOID:4362); primary ovarian insufficiency (Disease Ontology:DOID:5426); skin melanoma (Disease Ontology:DOID:8923); acute myeloid leukemia (Disease Ontology:DOID:9119)",
        "pathway": " (hsa:2175);  (R-HSA-6783310);  (R-HSA-9833482)",
        "pathway_count": 3,
        "publication_count": 270,
        "publication_id_list": "10082513;10094191;10210316;10348343;10400669;10521298;10620360;10626894;10648614;10807541;10848580;10866685;11091222;11096080;11134010;11152499;11156368;11237011;11238103;11238927;11239454;11278865;11313968;11337501;11350938;11438540;11500375;11781817;11855836;11909525;11939789;11985496;12231563;12397061;12724401;12882984;1373135;14585331;15229216;15299030;15502827;15572677;15737233;15752359;15907845;16116422;16179258;16179259;16373505;16431927;16600570;16717090;16916645;16943440;1695551;16982605;17079286;17196820;17289582;17412408;17460694;17525332;17924555;17924679;17938197;18077418;18082604;18096616;18174376;18550849;18691976;18835251;18931676;18957415;18987736;19109555;19111657;19229320;19416861;19561358;19589784;19596236;19710021;19733181;19804757;19838063;19995904;20102227;20347428;20347429;20385554;20395957;20519500;20603015;20603016;20603073;20670894;20671156;20685959;21072047;21123651;21294215;21464321;21518807;21636578;21701511;21764741;21937648;21978664;21994559;22214662;22258451;22266823;22287633;22343915;22396592;22424782;2247437;22510687;22692201;22705371;22986343;23084476;23186163;23229543;23325218;23481700;23698467;23723247;23732991;23806870;24076221;24347309;24389026;24623135;24623813;24659800;24715725;24726325;24753571;24905007;25418920;25430771;25500724;25576301;25653431;25848059;25892735;26154972;26432638;26446704;26488609;26716879;26817845;26992070;27208315;27269119;27398318;27423063;27449087;27600516;27846572;27893789;27974558;28069888;28167698;28218747;28228285;28281686;28514659;28765891;28832583;28834231;28904123;29170442;29175459;29231267;29242379;29331515;29348664;29393594;29394925;29395325;29440070;29501855;29508533;29769354;29786170;30174290;30315122;30524438;30770398;31031002;31217245;31530632;31844290;31937595;31998317;32093270;32157095;32161166;32357974;32387766;32488085;32502341;32716602;32801355;32897882;32938616;33141586;33298915;33392160;33592498;33691108;33717175;33808629;33911136;33912179;33936100;33968037;33981976;34019948;34171305;34174402;34211107;34405274;34509645;34561969;34932366;34974812;35051231;35494241;35685460;35947956;36010968;36241641;36712380;37127961;37549632;38191666;7491766;7515177;7545299;7565688;7693978;7737357;7903669;8576172;8576179;8661426;8810342;8896563;8910500;9034343;9079663;9169126;9371798;9399890;9442054;9521856;9528799;9687506;9711872;9721219;9737981;9742112;9789045;9819388;9920933;9929978",
        "class_list": "",
        "function": "BRCA-deficient metastatic prostate cancer has an adverse prognosis and distinct genomic phenotype., [RefSeq, PubMed]; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability., [UniProtKB]; FANCA c.3624C>T (p.Ser1208=) is a hypomorphic splice variant associated with delayed onset of Fanconi anemia., [RefSeq, PubMed]; The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 31,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 11,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5D923;B4DRI7;H3BSR5;O75266;Q6PL10;Q92497;Q96H18;Q9UEA5;Q9UEL8;Q9UEL9;Q9UPK3;Q9Y6M2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006281 DNA repair;GO:0036297 interstrand cross-link repair;GO:0045589 regulation of regulatory T cell differentiation;GO:0065003 protein-containing complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 27.3,
        "record_id": "O15360-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "B1AK53-1",
        "uniprot_id": "ESPN_HUMAN",
        "mass": 91733.0,
        "length": 854,
        "protein_name": "Espin",
        "gene_name": "ESPN",
        "organism": "Human",
        "refseq_name": "espin isoform 1",
        "refseq_ac": "NP_113663",
        "gene_names_uniprotkb": "ESPN; DFNB36; LP2654",
        "gene_names_refseq": "DFNA91; DFNB36; ESPN; LP2654; USH1M",
        "protein_names_uniprotkb": "Espin; Autosomal recessive deafness type 36 protein; Ectoplasmic specialization protein",
        "protein_names_refseq": "autosomal recessive deafness type 36 protein; ectoplasmic specialization protein; espin isoform 1",
        "tax_id": 9606,
        "disease": "autosomal recessive nonsyndromic deafness 36 (Disease Ontology:DOID:0110494); Usher syndrome, type 1M (MONDO:MONDO:0032841)",
        "pathway": " (hsa:83715);  (R-HSA-9662360);  (R-HSA-9662361)",
        "pathway_count": 3,
        "publication_count": 24,
        "publication_id_list": "10025409;10821263;11163272;11230166;11237011;15286153;15498874;15930085;18991276;25576301;26785147;26886463;28281779;28832583;29385671;29557506;29572253;31638198;32387766;32938616;33968037;33981976;35051231;35318648",
        "class_list": "",
        "function": "A significant inverse correlation was observed between miR-612 and Espin protein expression in melanoma tissues., [RefSeq, PubMed]; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells (PubMed:29572253). Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia (By similarity). Involved in the elongation of actin in stereocilia (PubMed:29572253). In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; The structures of Myo3 in complex with Espin1 not only elucidate the mechanism of the binding, but also reveal a Myo3-induced release of Espin1 auto-inhibition mechanism. Publication Status: Online-Only, [RefSeq, PubMed]; The utricles were then treated with a gamma-secretase inhibitor, followed by espin or control transduction and histochemistry. Although gamma-secretase inhibition increased the number of HCs, few had stereociliary arrays. In contrast, 46 h after espin1 transduction, a significant increase in hair-bundle-like structures was observed, [RefSeq, PubMed]; This gene encodes a multifunctional actin-bundling protein. It plays a major role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in various mechanosensory and chemosensory cells. Mutations in this gene are associated with autosomal recessive neurosensory deafness, and autosomal dominant sensorineural deafness without vestibular involvement. [provided by RefSeq, Nov 2009]., [RefSeq]; Ur study uncovers an additional USH gene, assigns the USH1 phenotype to a variant of ESPN and provides a 12th molecular component to the USH proteome, [RefSeq, PubMed]; Whirlin-espin interaction is important for the architecture of the USH2 complex and actin bundles cross-linked by espin. Our demonstration of whirlin N-terminal fragment interaction with espin, is significantly novel, providing insight into how these two proteins interact to form the USH2 complex., [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6XYB2;Q9H0A2;Q9Y329",
        "ec_number_list": "",
        "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0051015 actin filament binding;GO:0003779 actin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005903 brush border;GO:0031941 filamentous actin;GO:0005902 microvillus;GO:0032426 stereocilium tip",
        "go_biological_process": "GO:0051017 actin filament bundle assembly;GO:0007605 sensory perception of sound;GO:0030034 microvillar actin bundle assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "B1AK53-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BQ04-1",
        "uniprot_id": "RBM4B_HUMAN",
        "mass": 40150.0,
        "length": 359,
        "protein_name": "RNA-binding protein 4B",
        "gene_name": "RBM4B",
        "organism": "Human",
        "refseq_name": "RNA-binding protein 4B isoform 1",
        "refseq_ac": "NP_113680",
        "gene_names_uniprotkb": "RBM4B; RBM30",
        "gene_names_refseq": "RBM30; RBM4B; RBM4L; ZCCHC15; ZCCHC21B; ZCRB3B",
        "protein_names_uniprotkb": "RNA-binding protein 4B; RNA-binding motif protein 30; RNA-binding motif protein 4B; RNA-binding protein 30",
        "protein_names_refseq": "RNA-binding motif protein 30; RNA-binding protein 4B isoform 1; RNA-binding protein 4B; zinc finger CCHC-type and RNA binding motif 3B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:83759)",
        "pathway_count": 1,
        "publication_count": 84,
        "publication_id_list": "11237011;12429849;12628928;17074750;17081983;18446792;18708123;20068231;21248752;22424782;22544926;23481700;24714562;25576301;25645385;26154972;26375851;26992070;27543614;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28446606;28832583;28860189;28904123;29242379;29331515;29393594;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30429286;30524438;30779550;30833945;31154438;31222486;31844290;31848261;31937595;31998317;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34405274;34561969;34932366;35051231;35318648;35561310;35580925;36215666;36241641;36284347;39534244",
        "class_list": "",
        "function": "Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KT83",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0016607 nuclear speck;GO:0032991 protein-containing complex;GO:0005634 nucleus",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0006417 regulation of translation;GO:0007623 circadian rhythm;GO:0008380 RNA splicing;GO:0032922 circadian regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 8.8,
        "record_id": "Q9BQ04-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P35555-1",
        "uniprot_id": "FBN1_HUMAN",
        "mass": 312298.0,
        "length": 2871,
        "protein_name": "Fibrillin-1",
        "gene_name": "FBN1",
        "organism": "Human",
        "refseq_name": "fibrillin-1 isoform a preproprotein",
        "refseq_ac": "NP_000129",
        "gene_names_uniprotkb": "FBN1; FBN",
        "gene_names_refseq": "ACMICD; ECTOL1; FBN1; FBN; GPHYSD2; MASS; MFLS; MFS1; OCTD; SGS; SSKS; WMS2; WMS",
        "protein_names_uniprotkb": "Fibrillin-1",
        "protein_names_refseq": "asprosin; epididymis secretory sperm binding protein; fibrillin 15; fibrillin-1 isoform a preproprotein; fibrillin-1 preproprotein",
        "tax_id": 9606,
        "disease": "Weill-Marchesani syndrome (Disease Ontology:DOID:0050475); CREST syndrome (Disease Ontology:DOID:0060218); scoliosis (Disease Ontology:DOID:0060249); Weill-Marchesani syndrome 2 (Disease Ontology:DOID:0061274); aortic dissection (Disease Ontology:DOID:0080685); autosomal dominant isolated ectopia lentis 1 (Disease Ontology:DOID:0111150); acromicric dysplasia (Disease Ontology:DOID:0111243); stiff skin syndrome (Disease Ontology:DOID:0111561); geleophysic dysplasia 2 (Disease Ontology:DOID:0111726); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); Marfan syndrome (Disease Ontology:DOID:14323); glomerulonephritis (Disease Ontology:DOID:2921); mixed connective tissue disease (Disease Ontology:DOID:3492); aortic aneurysm (Disease Ontology:DOID:3627); systemic scleroderma (Disease Ontology:DOID:418); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); liver cirrhosis (Disease Ontology:DOID:5082); type 2 diabetes mellitus (Disease Ontology:DOID:9352); refractive error (Disease Ontology:DOID:9835); mitral valve prolapse (Disease Ontology:DOID:988); MASS syndrome (MONDO:MONDO:0011431); progeroid and marfanoid aspect-lipodystrophy syndrome (MONDO:MONDO:0014831)",
        "pathway": " (hsa:2200);  (R-HSA-1474228);  (R-HSA-1566948);  (R-HSA-2129379);  (R-HSA-216083);  (R-HSA-2173789);  (R-HSA-381426);  (R-HSA-8957275)",
        "pathway_count": 8,
        "publication_count": 368,
        "publication_id_list": "10.1101/2023.09.13.557529;10025398;10026136;10077652;10198291;10209034;10218588;10229672;10366422;10386589;10424889;10425041;10438935;10441597;10512690;10543983;10544250;10593924;10605720;10614670;10633129;10636927;10640428;10646116;10673366;10681634;10694921;10706100;10713152;10809722;10810289;10811134;10898936;10912521;10930463;10936461;10951195;10982388;10986281;10990447;11100470;11141505;11158056;11158588;11237011;11250653;11264294;11316783;11375993;11390472;11461921;11481325;11518510;11522292;11572855;11606061;11700157;11713259;11739083;11751371;11788658;11826022;11872628;11970960;11980922;12161601;12203987;12203992;12241545;12358597;12379487;12402346;12415008;12429738;12446365;12466191;12482908;12496264;12511552;12525539;12585966;12682293;12727852;12807887;12810533;12837131;12843408;12904166;1301946;1333888;1370451;1383255;1400330;14695540;14701737;14973287;15054843;15062093;15126567;15131124;15161917;15165854;15221638;15234972;15240572;15308688;15330449;15345499;15350224;15383545;15469690;15485880;15525596;15564041;15591058;15642270;1569206;15713743;15790312;1588291;15899827;15958533;15980072;16002701;16051604;16133547;16220557;16222657;16239428;1649600;16631740;16731529;16754661;16825321;16906757;16933105;1698775;17047378;1707285;1708799;17158881;17249697;17255108;17293099;17312271;17324935;17332331;17339034;17354228;17608959;17657824;17701892;17968485;17985932;18339631;18434311;18435798;18469808;1852206;1852207;1852208;1860873;18658137;18710925;18775695;19010778;19159218;19293843;19349279;19446531;19502598;19533785;19570982;19571574;19657146;19714641;19720988;19941982;20033473;2010551;20142769;20375004;20547088;20625381;20705068;20803651;20979188;21030783;21034599;21297635;21402694;21441952;21542060;21594992;21594993;21646718;21670566;21683322;21784848;21864727;22159414;22539938;22772377;22884367;23010571;23035980;23090970;23278365;23290524;23374253;23845380;24035709;24039054;24039232;24190977;24275569;24613577;24665001;24715725;2476804;2479552;24982166;25418920;25863307;25979247;26091039;26154972;26601954;26860060;27026396;27087445;2739055;27846572;27920218;28514659;28832583;28904123;29104036;29242379;29391424;29508533;29557506;29741879;30237853;30315122;30459171;30524438;30853600;31154438;31230984;31775140;31844290;31848261;32387766;32502341;32938616;33298915;33592498;33717175;33968037;34211107;34411563;34561969;34932366;35051231;35254053;35289036;36010968;36241641;37074911;37217939;38665916;39219382;6123066;7075587;7500359;7505120;7519608;7523391;7525263;7525578;7525634;7525824;7527330;7534784;7538844;7541634;7542249;7543116;7547873;7559467;7588299;7611299;7683646;7685013;7689487;7691719;7693660;7737999;7738200;7762551;7802039;7870075;7911051;7951214;7977366;8004112;8040326;8047140;8071963;8118028;8136837;8188302;8226919;8242743;8281141;8344274;8364578;8406497;8430317;8504310;8560266;8568869;8594563;8617364;8626565;8653794;8781553;8798654;8817670;8838667;8863159;8882780;8894645;8910476;8947046;8964575;8980228;8988160;9016526;9065415;9115292;9148753;9150726;9233797;9251239;9254848;9311995;9338581;9338588;9346966;9362480;9401003;9443892;9452085;9461298;9497324;9565552;9709957;9725916;9733769;9786878;9817919;9837823;9852107;9858236;9865696;9922210",
        "class_list": "",
        "function": "A Novel Heterozygous Intronic FBN1 Variant Contributes to Aberrant RNA Splicing in Marfan Syndrome., [RefSeq, PubMed]; Adipokine secreted by white adipose tissue that plays an important regulatory role in the glucose metabolism of liver, muscle and pancreas (PubMed:27087445, PubMed:30853600). Hormone that targets the liver in response to fasting to increase plasma glucose levels (PubMed:27087445). Binds the olfactory receptor OR4M1 at the surface of hepatocytes and promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation (PubMed:27087445, PubMed:31230984). May act as a regulator of adaptive thermogenesis by inhibiting browning and energy consumption, while increasing lipid deposition in white adipose tissue (By similarity). Also acts as an orexigenic hormone that increases appetite: crosses the blood brain barrier and exerts effects on the hypothalamus (By similarity). In the arcuate nucleus of the hypothalamus, asprosin directly activates orexigenic AgRP neurons and indirectly inhibits anorexigenic POMC neurons, resulting in appetite stimulation (By similarity). Activates orexigenic AgRP neurons via binding to the olfactory receptor OR4M1 (By similarity). May also play a role in sperm motility in testis via interaction with OR4M1 receptor (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Authors discovered a protein hormone that regulates glucose homeostasis. It is the C-terminal cleavage product of profibrillin (encoded by FBN1). Its absence in humans results in a unique pattern of metabolic dysregulation that includes partial lipodystrophy, accompanied by reduced plasma insulin, while maintaining euglycemia., [RefSeq, PubMed]; Progressive pathological aortic root enlargement as the result of degeneration of microfibril architecture and consequential loss of extracellular matrix integrity due to fibrillin-1 (FBN1) mutations are commonly diagnosed clinical manifestations of MFS. Review article, [RefSeq, PubMed]; Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues (PubMed:15062093, PubMed:1860873). Fibrillin-1-containing microfibrils provide long-term force bearing structural support (PubMed:27026396). In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin (PubMed:27026396). In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles (PubMed:27026396). Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (PubMed:27026396). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11 (PubMed:24039232). This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1 (PubMed:12807887, PubMed:17158881). Binds heparin and this interaction has an important role in the assembly of microfibrils (PubMed:11461921)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate two proteins including the extracellular matrix component fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. These microfibrils provide force-bearing structural support in elastic and nonelastic connective tissue throughout the body. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis. Mutations in this gene are associated with Marfan syndrome and the related MASS phenotype, as well as ectopia lentis syndrome, Weill-Marchesani syndrome, Shprintzen-Goldberg syndrome and neonatal progeroid syndrome. [provided by RefSeq, Apr 2016]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 12,
        "reported_o_glycosites": 27,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 14,
        "reported_o_glycosites_with_glycan": 30,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 15,
        "total_reported_o_glycosites": 30,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 15,
        "total_o_glycosites": 30,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 2,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 283,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 111,
        "disease_count": 23,
        "glyco_site_count": 48,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RUU0;D2JYH6;Q15972;Q75N87",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0031012 extracellular matrix;GO:0005604 basement membrane",
        "go_biological_process": "GO:0007507 heart development;GO:0033627 cell adhesion mediated by integrin;GO:0001501 skeletal system development;GO:0042593 glucose homeostasis;GO:0006006 glucose metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 52.5,
        "record_id": "P35555-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WUF5-1",
        "uniprot_id": "IASPP_HUMAN",
        "mass": 89091.0,
        "length": 828,
        "protein_name": "RelA-associated inhibitor",
        "gene_name": "PPP1R13L",
        "organism": "Human",
        "refseq_name": "relA-associated inhibitor",
        "refseq_ac": "NP_001135974",
        "gene_names_uniprotkb": "PPP1R13L; IASPP; NKIP1; PPP1R13BL; RAI",
        "gene_names_refseq": "ARCME; CMAEA; IASPP; NKIP1; PPP1R13L; RAI4; RAI",
        "protein_names_uniprotkb": "RelA-associated inhibitor; Inhibitor of ASPP protein; NFkB-interacting protein 1; PPP1R13B-like protein; Protein iASPP",
        "protein_names_refseq": "NFkB interacting protein 1; PPP1R13B-like protein; inhibitor of ASPP protein; inhibitor of apoptosis stimulating protein of p53; protein iASPP; protein phosphatase 1, regulatory (inhibitor) subunit 13 like; relA-associated inhibitor; retinoic acid induced 4",
        "tax_id": 9606,
        "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); autosomal recessive disease (Disease Ontology:DOID:0050737); arrhythmogenic cardiomyopathy with variable ectodermal abnormalities (MONDO:MONDO:0957795)",
        "pathway": " (hsa:10848);  (R-HSA-6804759)",
        "pathway_count": 2,
        "publication_count": 80,
        "publication_id_list": "10329733;10336463;11237011;11684014;12134007;12203124;12494467;12524540;14729977;15489900;15598651;16382142;16964243;17081983;17145718;17719541;18212344;18275817;18452278;18669648;18676979;18691976;19303885;19651622;19664995;19690332;20068231;20075864;22538442;22864287;22975685;23186163;23481700;24129315;24714389;25356872;25576301;27503676;27846572;27862975;27920218;28069640;28228285;28904123;29242379;29393594;29557506;30105797;30315122;30429286;30484775;30779550;31154438;31217245;31492838;31844290;31848261;32157095;32161166;32357974;32502341;32666529;32938616;33298915;33592498;33912179;33968037;33981976;34087483;34171305;35051231;35254053;35580925;35717675;35924320;35933355;36010968;37147350;37698259;40136647",
        "class_list": "",
        "function": "Chitosan-Gelatin-EGCG Nanoparticle-Meditated LncRNA TMEM44-AS1 Silencing to Activate the P53 Signaling Pathway for the Synergistic Reversal of 5-FU Resistance in Gastric Cancer., [RefSeq, PubMed]; Common variants of pro-inflammatory gene IL1B and interactions with PPP1R13L and POLR1G in relation to lung cancer among Northeast Chinese. Publication Status: Online-Only, [RefSeq, PubMed]; Effect of RAI on transcription and replication of human immunodeficiency virus type 1 (HIV-1)., [RefSeq, PubMed]; IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]., [RefSeq]; Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Variable phenotype of a null PPP1R13L allele in children with dilated cardiomyopathy., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 37,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2PNZ9;Q5DU71;Q5I1X4;Q6P1R7;Q6PKF8;Q9Y290",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity;GO:0045296 cadherin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0050728 negative regulation of inflammatory response;GO:0045597 positive regulation of cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "Q8WUF5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q95460-1",
        "uniprot_id": "HMR1_HUMAN",
        "mass": 39366.0,
        "length": 341,
        "protein_name": "Major histocompatibility complex class I-related protein 1",
        "gene_name": "MR1",
        "organism": "Human",
        "refseq_name": "major histocompatibility complex class I-related protein 1 isoform 2 precursor",
        "refseq_ac": "NP_001181928",
        "gene_names_uniprotkb": "MR1",
        "gene_names_refseq": "HLALS; MR1",
        "protein_names_uniprotkb": "Major histocompatibility complex class I-related protein 1; Class I histocompatibility antigen-like protein; MHC class I-related protein 1",
        "protein_names_refseq": "MHC class I-like antigen MR-1; MHC class I-related protein 1; MHC class-I related-gene protein; major histocompatibility complex class I-related gene protein; major histocompatibility complex class I-related protein 1 isoform 2 precursor; major histocompatibility complex class I-related protein 1; major histocompatibility complex, class I-like sequence",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3140)",
        "pathway_count": 1,
        "publication_count": 96,
        "publication_id_list": "10.1101/2023.09.13.557529;11019920;11237011;12794138;18068122;19416870;19760593;20581831;22645359;22692454;23051753;23457030;23481700;23846752;24101382;24190977;24695216;24715725;25418920;25505266;25576301;25880248;25892735;26154972;26795251;26992070;27043408;27452731;27527800;27846572;27920218;28166217;28218747;28228285;28832583;28904123;29242379;29437277;29493099;29508533;29557506;29632046;30315122;30410026;30429286;31092671;31113973;31154438;31530632;31844290;31848261;31959982;32130899;32157095;32350084;32357974;32488085;32502341;32709702;32938616;32958637;32983136;33123756;33141586;33298915;33592498;33633747;33912179;33968037;34087483;34211107;34351076;34357683;34433824;34509645;34932366;35051231;35154160;35251023;35318648;35580925;35725941;36010968;36241641;36284347;36845106;36944969;37773272;38017021;38157945;39445059;39589872;39701104;7624800;9780177;9784382",
        "class_list": "",
        "function": "Allele MR1*01: Presents microbial-derived metabolite 5-OP-RU to semi-invariant TRAV1.2-TRAJ33-TRBV6.1 (A-F7) TCR on MAIT cells (PubMed:39589872). Presents nucleobase carbonyl adducts generated during oxidative stress. Captures M3Ade, a nucleobase adduct composed of one adenine modified by a malondialdehyde trimer, for recognition by MR1-restricted T cell clones expressing a polyclonal TCR repertoire (PubMed:39701104). Displays moderate binding affinity toward tumor-enriched pyridoxal and pyridoxal 5'-phosphate antigens (PubMed:39589872)., [UniProtKB, PubMed, PubMed]; Allele MR1*04: Presents tumor-enriched metabolite pyridoxal to pan-cancer 7.G5 TCR on T cells enabling preferential recognition of cancer cells. May act as an alloantigen., [UniProtKB, PubMed, PubMed]; Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells (PubMed:19416870, PubMed:23457030, PubMed:22692454, PubMed:23051753, PubMed:24101382, PubMed:23846752, PubMed:26795251). In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TRAV1.2 TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (PubMed:20581831, PubMed:24101382, PubMed:24695216, PubMed:26795251). Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively (PubMed:24695216, PubMed:32958637, PubMed:32709702). May present microbial antigens to various TRAV1-2-negative MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin (PubMed:27527800, PubMed:31113973). Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells (PubMed:23846752, PubMed:24695216, PubMed:27527800). During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (By similarity). Acts as an immune sensor of cancer cell metabolome (PubMed:31959982). May present a tumor-specific or -associated metabolite essential for cancer cell survival to a 'pan-cancer' TCR consisting of TRAV38.2-DV8*TRAJ31 alpha chain paired with a TRBV25.1*TRBJ2.3 beta chain on a non-MAIT CD8-positive T cell clone (MC.7.G5), triggering T cell-mediated killing of a wide range of cancer cell types (PubMed:31959982)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Characterization of the TCRbeta repertoire of peripheral MR1-restricted MAIT cells in psoriasis vulgaris patients. Publication Status: Online-Only, [RefSeq, PubMed]; Control of the temporal development of Alzheimer's disease pathology by the MR1/MAIT cell axis. Publication Status: Online-Only, [RefSeq, PubMed]; MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. [provided by RefSeq, Jul 2015]., [RefSeq]; MR1 antigen presentation to MAIT cells and other MR1-restricted T cells. Review article, [RefSeq, PubMed]; Suppression of MR1 by human cytomegalovirus inhibits MAIT cell activation. Publication Status: Online-Only, [RefSeq, PubMed]; The MR1/MAIT cell axis in CNS diseases. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2V9;B4E3B1;O97985;O97986;Q53GM1;Q95HB8;Q9MY23;Q9NPL2;Q9TQB3;Q9TQB9;Q9TQK3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030881 beta-2-microglobulin binding;GO:0042608 T cell receptor binding;GO:0032393 MHC class I receptor activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006955 immune response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0002474 antigen processing and presentation of peptide antigen via MHC class I",
        "synthesized_glycan_count": 0,
        "hit_score": 9.9,
        "record_id": "Q95460-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P26367-1",
        "uniprot_id": "PAX6_HUMAN",
        "mass": 46683.0,
        "length": 422,
        "protein_name": "Paired box protein Pax-6",
        "gene_name": "PAX6",
        "organism": "Human",
        "refseq_name": "paired box protein Pax-6 isoform a",
        "refseq_ac": "NP_000271",
        "gene_names_uniprotkb": "PAX6; AN2",
        "gene_names_refseq": "AN1; AN2; AN; ASGD5; D11S812E; FVH1; MGDA; PAX6; WAGR",
        "protein_names_uniprotkb": "Paired box protein Pax-6; Aniridia type II protein; Oculorhombin",
        "protein_names_refseq": "Aniridia 1; Aniridia 2; alternative protein PAX6; aniridia type II protein; oculorhombin; paired box 6 PAX6-12a isoform; paired box 6 PAX6A-ASdel6 isoform; paired box 6 PAX6A-ASdel6-AS7 isoform; paired box 6 PAX6A-del6 isoform; paired box 6 PAX6B-ASdel6 isoform; paired box 6 PAX6D isoform; paired box homeotic gene-6; paired box protein Pax-6 isoform a",
        "tax_id": 9606,
        "disease": "Peters anomaly (Disease Ontology:DOID:0060673); foveal hypoplasia 1 (Disease Ontology:DOID:0070530); aniridia 1 (Disease Ontology:DOID:0070532); anterior segment dysgenesis 5 (Disease Ontology:DOID:0080610); cataract 27 (Disease Ontology:DOID:0110233); autosomal dominant keratitis (Disease Ontology:DOID:0111383); bilateral optic nerve hypoplasia (Disease Ontology:DOID:0111531); glucose intolerance (Disease Ontology:DOID:10603); microphthalmia (Disease Ontology:DOID:10629); juvenile glaucoma (Disease Ontology:DOID:1068); coloboma of optic nerve (Disease Ontology:DOID:11975); coloboma (Disease Ontology:DOID:12270); aniridia (Disease Ontology:DOID:12271); paranoid schizophrenia (Disease Ontology:DOID:1229); autistic disorder (Disease Ontology:DOID:12849); Smith-Lemli-Opitz syndrome (Disease Ontology:DOID:14692); transient cerebral ischemia (Disease Ontology:DOID:224); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); cataract (Disease Ontology:DOID:83); type 2 diabetes mellitus (Disease Ontology:DOID:9352); congenital nystagmus (Disease Ontology:DOID:9649); aniridia 2 (MONDO:MONDO:0014937)",
        "pathway": " (hsa:5080);  (R-HSA-210745);  (R-HSA-381771);  (R-HSA-400511);  (R-HSA-5617472);  (R-HSA-9823739)",
        "pathway_count": 6,
        "publication_count": 124,
        "publication_id_list": "10234503;10346815;10366038;10441571;10737978;10777502;10955655;11237011;11309364;11553050;11564718;11826019;11978683;12540594;12552561;12634864;12651102;12721955;12810581;1345175;14719035;14719797;1499644;15126524;15584901;15619630;15867264;16079151;16219666;16407227;16493447;16549775;16728727;1684738;17065399;17185360;17428788;1756725;17595013;17660710;17681422;17713478;17761849;17851529;18202141;18467663;18519800;18593849;18669648;18781158;19001044;19115252;19232136;19414065;19747919;1975088;19782034;19854132;19917615;20068231;20074535;20085832;21850189;22569366;22705304;22879880;23219899;23534758;23630040;24033328;24174538;24290376;24312487;24586203;25101834;25135475;2570724;25913784;27052315;2890159;29557506;29914532;30429286;30524438;30828317;31154438;32119511;32157095;33214551;33592498;33981976;34019948;34171305;35138101;35318648;36581221;3841689;3900195;7488013;7501971;7668281;7831296;7883856;7906964;7908827;7958875;8100523;8162071;8364574;8428636;8640214;8674428;8759021;8798518;9147640;9218805;9272954;9281415;9482572;9482740;9538891;9792406;9856761;9931324",
        "class_list": "",
        "function": "In the presence of Pax6(S), calcium channel beta(3) subunit is translocated from the cytoplasm to the nucleus, [RefSeq, PubMed]; Pax6 is a multifunctional player regulating proliferation and differentiation through the control of expression of different downstream molecules in a highly context-dependent manner [review] Review article, [RefSeq, PubMed]; This gene encodes paired box protein Pax-6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to a conserved paired box domain, a hallmark feature of this gene family, the encoded protein also contains a homeobox domain. Both domains are known to bind DNA and function as regulators of gene transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing results in multiple transcript variants encoding different isoforms. Interestingly, inclusion of a particular alternate coding exon has been shown to increase the length of the paired box domain and alter its DNA binding specificity. Consequently, isoforms that carry the shorter paired box domain regulate a different set of genes compared to the isoforms carrying the longer paired box domain. [provided by RefSeq, Mar 2019]., [RefSeq]; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1-mediated gene expression (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 22,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6N006;Q99413",
        "ec_number_list": "",
        "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003723 RNA binding;GO:0019901 protein kinase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0003322 pancreatic A cell development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 12.7,
        "record_id": "P26367-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14713-1",
        "uniprot_id": "ITBP1_HUMAN",
        "mass": 21782.0,
        "length": 200,
        "protein_name": "Integrin beta-1-binding protein 1",
        "gene_name": "ITGB1BP1",
        "organism": "Human",
        "refseq_name": "integrin beta-1-binding protein 1 isoform 1",
        "refseq_ac": "NP_001305995",
        "gene_names_uniprotkb": "ITGB1BP1; ICAP1",
        "gene_names_refseq": "ICAP-1A; ICAP-1B; ICAP-1alpha; ICAP1A; ICAP1B; ICAP1; ITGB1BP1",
        "protein_names_uniprotkb": "Integrin beta-1-binding protein 1; ICAP-1; Integrin cytoplasmic domain-associated protein 1",
        "protein_names_refseq": "bodenin; integrin beta-1-binding protein 1 isoform 1; integrin beta-1-binding protein 1; integrin cytoplasmic domain-associated protein 1-alpha; integrin cytoplasmic domain-associated protein 1-beta",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9270)",
        "pathway_count": 1,
        "publication_count": 34,
        "publication_id_list": "11237011;11741838;11741908;11807099;11854171;11919189;12473654;14759258;15703214;17916086;20616313;21768292;25418920;26929215;28049720;28063628;29242379;29393594;29437277;29557506;29632046;31844290;32005669;32157095;32357974;32387766;32502341;33592498;34171305;35494241;36010968;9281591;9813144;9867804",
        "class_list": "",
        "function": "ICAP-1 monoubiquitylation helps in switching from ROCK2-mediated to MRCKalpha-mediated cell contractility. Erratum:[J Cell Sci. 2017 Mar 15;130(6):1195. doi: 10.1242/jcs.202218. PMID: 28298614], [RefSeq, PubMed]; Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Serine phosphorylation of the small phosphoprotein ICAP1 inhibits its nuclear accumulation., [RefSeq, PubMed]; Site-directed mutagenesis showed that Leu(135), Ile(138), and Ile(139) of Icap1 alpha, and Leu(82) and Tyr(144), are required for the Icap1 alpha-beta(1) integrin interaction, [RefSeq, PubMed]; The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 16,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D6W4Y9;O14714;Q53RS0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0005092 GDP-dissociation inhibitor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:0010764 negative regulation of fibroblast migration;GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "O14713-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P02810-1",
        "uniprot_id": "PRPC_HUMAN",
        "mass": 17015.0,
        "length": 166,
        "protein_name": "Salivary acidic proline-rich phosphoprotein 1/2",
        "gene_name": "PRH1; PRH2; PRR4",
        "organism": "Human",
        "refseq_name": "salivary acidic proline-rich phosphoprotein 1/2 preproprotein",
        "refseq_ac": "NP_001103683",
        "gene_names_uniprotkb": "PRH1; PRH2; PRR4; PRH1",
        "gene_names_refseq": "PRH2; PRP-1/PRP-2; Pr; pr1/Pr2",
        "protein_names_uniprotkb": "Salivary acidic proline-rich phosphoprotein 1/2; Db-F; Db-s; PIF-F; PIF-S; PRP-1/PRP-2; PRP-3/PRP-4; Parotid acidic protein; Parotid double-band protein; Parotid isoelectric focusing variant protein; Parotid proline-rich protein 1/2; Pa; Pr1/Pr2; Protein A; Protein C",
        "protein_names_refseq": "acidic salivary proline-rich protein, HaeIII type, 2; parotid acidic protein; parotid double-band protein; parotid proline-rich protein 1/2; protein C; salivary acidic proline-rich phosphoprotein 1/2 preproprotein; salivary acidic proline-rich phosphoprotein 1/2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5554);  (hsa:5555)",
        "pathway_count": 2,
        "publication_count": 30,
        "publication_id_list": "10627138;10684652;10858503;11237011;15693058;18463091;1849422;20879038;26091039;27452731;27920218;28649982;29191562;29242379;29314611;29393594;29632046;29786170;2993301;3009472;30524438;31092671;3196309;3687941;3710693;38364699;438215;7228490;7380845;7390979",
        "class_list": "",
        "function": "Human PRH1, PRH2 susceptibility and resistance and Streptococcus mutans virulence phenotypes specify different microbial profiles in caries., [RefSeq, PubMed]; PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth., [UniProtKB]; This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. In western population this locus is commonly biallelic and encodes proline-rich protein (PRP) isoforms, PRP-1 and PRP-2. The reference genome encodes the PRP-1 allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Oct 2015]., [RefSeq]; We investigated whether PRH1 and PRH2 polymorphisms in saliva acidic proline-rich protein (PRP) receptors for indigenous bacteria match and predict individual differences in the development of caries..They instead developed 3.9-fold more caries than P1 children from plaque accumulation in general when treated with orthodontic multibrackets; and had basic PRP polymorphisms and low DMBT1-mediated S. mutans adhesion, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 2,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2VCM0;A3KN66;A5D902;B2RMW2;Q4VBP2;Q53XA2;Q6P2F6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "P02810-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P42226-1",
        "uniprot_id": "STAT6_HUMAN",
        "mass": 94135.0,
        "length": 847,
        "protein_name": "Signal transducer and activator of transcription 6",
        "gene_name": "STAT6",
        "organism": "Human",
        "refseq_name": "signal transducer and activator of transcription 6 isoform 1",
        "refseq_ac": "NP_001171549",
        "gene_names_uniprotkb": "STAT6",
        "gene_names_refseq": "D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C; STAT6",
        "protein_names_uniprotkb": "Signal transducer and activator of transcription 6; IL-4 Stat",
        "protein_names_refseq": "STAT, interleukin4-induced; signal transducer and activator of transcription 6 isoform 1; signal transducer and activator of transcription 6, interleukin-4 induced; transcription factor IL-4 STAT",
        "tax_id": 9606,
        "disease": "renal fibrosis (Disease Ontology:DOID:0050855); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); lipoid nephrosis (Disease Ontology:DOID:10966); urinary schistosomiasis (Disease Ontology:DOID:1394); rectum adenocarcinoma (Disease Ontology:DOID:1996); colon adenocarcinoma (Disease Ontology:DOID:234); asthma (Disease Ontology:DOID:2841); gastric adenocarcinoma (Disease Ontology:DOID:3717); myocarditis (Disease Ontology:DOID:820); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); hyper-IgE syndrome 6, autosomal dominant, with recurrent infections (MONDO:MONDO:0957807)",
        "pathway": " (hsa:6778);  (R-HSA-186763);  (R-HSA-3249367);  (R-HSA-6785807);  (R-HSA-9976102)",
        "pathway_count": 5,
        "publication_count": 248,
        "publication_id_list": "10023775;10219247;10369418;10508235;10510379;10579907;10586089;10867011;11058569;11084045;11104795;11120780;11237011;11278437;11278729;11356008;11404481;11463377;11839743;11944890;11960372;12093868;12138096;12223527;12242343;12600988;12832402;1314164;1374684;1375321;1396585;14634100;14712222;14757047;15069079;15116091;15261459;15584925;15805299;15869882;15950906;16007214;16048438;16107692;16181056;16205632;16236134;16397018;16451196;16510571;16540365;16606674;17210636;17427945;17458857;17572495;18243101;18353781;18447642;18494930;18644974;19124156;19185846;19307177;19367337;19397496;20068231;20493732;20668749;21102457;21123173;21252155;21689689;21730069;21937440;21994466;22000020;22046235;22142941;22205702;22223895;22383755;22394562;22424782;22544926;22619329;22693070;22706990;22851691;22869377;22898188;23086340;23124025;23172665;23455323;23481700;23555662;23845085;23967200;24097101;24366607;2466336;24714562;24715725;2472219;24743777;25234944;25418920;25428220;25576301;25645385;25802875;26154972;26208975;26375851;26728094;26758199;26768311;26951976;26992070;27317770;27397612;27600516;27796300;27846572;27862975;27920218;28099521;28218747;28228285;28414040;28430601;28514659;28649982;28832583;28834231;28904123;29242379;29331515;29371260;29393594;29437277;29485045;29485866;29493099;29508533;29557506;29632046;29632711;29769354;29771943;29786170;30315122;30379171;30429286;30524438;30532138;30573663;30779550;30833945;31154438;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34171305;34185709;34211107;34357683;34405274;34509645;34561969;34932366;35051231;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36758835;36884218;37316763;37938771;38285120;38459596;38523251;39188021;39405377;39894887;7510216;7512451;7529288;7685273;7691811;7692233;7795521;7796300;7898939;7907877;7935391;8085155;8388543;8443409;8602263;8621622;8647855;8657151;8663118;8668165;8797861;8816495;8940081;9013879;9484840;9488729;9546424;9651359;9723655;9736340;9739761;9782085;9822675;9874564",
        "class_list": "",
        "function": "Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; NAB2::STAT6 fusions and genome-wide DNA methylation profiling: Predictors of patient outcomes in meningeal solitary fibrous tumors., [RefSeq, PubMed]; STAT4 and STAT6, their role in cellular and humoral immunity and in diverse human diseases. Review article, [RefSeq, PubMed]; STAT6 mutations enriched at diffuse large B-cell lymphoma relapse reshape the tumor microenvironment., [RefSeq, PubMed]; The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters., [RefSeq, PubMed]; The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 12,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K316;B7ZA27;F5GXI9;Q5FBW5;Q71UP4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin",
        "go_biological_process": "GO:0035771 interleukin-4-mediated signaling pathway;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006952 defense response;GO:0042127 regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 25.1,
        "record_id": "P42226-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q0JRZ9-1",
        "uniprot_id": "FCHO2_HUMAN",
        "mass": 88924.0,
        "length": 810,
        "protein_name": "F-BAR domain only protein 2",
        "gene_name": "FCHO2",
        "organism": "Human",
        "refseq_name": "F-BAR domain only protein 2 isoform b",
        "refseq_ac": "NP_001139504",
        "gene_names_uniprotkb": "FCHO2",
        "gene_names_refseq": "FCHO2",
        "protein_names_uniprotkb": "F-BAR domain only protein 2",
        "protein_names_refseq": "F-BAR domain only protein 2 isoform b; F-BAR domain only protein 2; FCH domain only 2; FCH domain only protein 2",
        "tax_id": 9606,
        "disease": "early-onset Parkinson's disease (Disease Ontology:DOID:0060894)",
        "pathway": " (hsa:115548);  (R-HSA-8856825);  (R-HSA-8856828)",
        "pathway_count": 3,
        "publication_count": 255,
        "publication_id_list": "10097102;10436022;10535736;10542231;10559856;10559861;10559924;10567358;10613896;10625686;10766823;10769163;10983987;11071885;11076969;11082044;11231140;11237011;11239472;11247302;11454741;11470803;11516654;11517213;11532990;11577110;11588219;11877457;11877461;11889126;11919637;11927540;11988742;12057195;12086608;12213833;12221107;12234931;12429842;12447393;12451172;12464600;12717448;12847086;12944396;12952949;12958364;1317852;14555962;14581451;14617351;14622578;14622579;14662753;14726597;15134832;15252009;15260957;15318165;15339664;1535555;15473838;15502812;15502813;15649145;15671180;15703209;15728179;15802264;15895077;15916959;16103228;16159959;16215232;16326391;16410077;16459302;16460808;16516836;16707488;16723738;16798879;16880396;16903783;16964243;17018281;17035995;17081983;17158794;17267500;17360967;17456551;17494869;17512409;17522231;17540576;17609109;17681954;17713526;17762867;17765681;17978091;18032517;18093523;18166656;18199683;18388313;18452278;1847920;18669648;18767875;18775314;18790740;18819912;18981233;19092055;19140243;19287005;19296720;19413330;19458185;19536138;19575674;19603039;19651622;19664994;1968060;19696796;19696798;19713939;19732400;19776351;19809571;19853559;20033059;20059951;20068231;20211604;20231386;20351096;20428113;20448150;20826345;20946875;21102408;2115402;21187331;21278753;21316588;21406692;21445324;21482805;21499258;21613550;21762413;21779028;21841790;21883765;21927000;21927001;21962517;21995445;22099461;22118466;22233676;22323290;22357968;22484487;22505844;2257624;22815487;22863004;22942912;23186163;23297414;23536704;23823722;23861397;23891661;24130457;24186068;24275569;24384571;24581490;24680432;24715725;24746795;24789820;24966051;25107275;25303366;25341920;25576301;26042225;26403691;26829388;26992070;27600516;27846572;27862975;28218747;28834231;2890644;29242379;29393594;29557506;29632711;29786170;29789417;30379171;30429286;30620550;31844290;32157095;32387766;32488085;32897882;32938616;32983136;33592498;33820972;33968037;33981976;34087483;34171305;3417785;34509645;35044298;35051231;35254053;35580925;35708677;36010968;36241641;36284347;37938771;38311675;6146630;7569928;7822302;7877694;8524399;8552632;8553074;8837779;9092476;9100026;9169477;9303539;9427626;9428629;9635431;9723620;9736607;9812899",
        "class_list": "",
        "function": "CircFCHO2 promotes gastric cancer progression by activating the JAK1/STAT3 pathway via sponging miR-194-5p. Erratum:[Cell Cycle. 2024 Feb;23(3):338. doi: 10.1080/15384101.2024.2317629. PMID: 38526078], [RefSeq, PubMed]; Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1. Publication Status: Online-Only, [RefSeq, PubMed]; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Liquid-like protein interactions catalyse assembly of endocytic vesicles., [RefSeq, PubMed]; Structural organization and dynamics of FCHo2 docking on membranes. Publication Status: Online-Only, [RefSeq, PubMed]; This structure shows a distant relationship to curvature-sensing BAR modules, and suggests how similar coiled-coil architectures in the BAR superfamily have evolved to expand the repertoire of membrane-sculpting possibilities, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 21,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K6W7;B2RNQ9;B4DHK0;E9PG79;Q0JTJ3;Q96CF5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0001786 phosphatidylserine binding;GO:0035091 phosphatidylinositol binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0030136 clathrin-coated vesicle",
        "go_biological_process": "GO:0010324 membrane invagination;GO:0072659 protein localization to plasma membrane;GO:0048268 clathrin coat assembly;GO:0072583 clathrin-dependent endocytosis;GO:0048488 synaptic vesicle endocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 26.2,
        "record_id": "Q0JRZ9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P11474-1",
        "uniprot_id": "ERR1_HUMAN",
        "mass": 45510.0,
        "length": 423,
        "protein_name": "Steroid hormone receptor ERR1",
        "gene_name": "ESRRA",
        "organism": "Human",
        "refseq_name": "steroid hormone receptor ERR1 isoform 1",
        "refseq_ac": "NP_001269379",
        "gene_names_uniprotkb": "ESRRA; ERR1; ESRL1; NR3B1",
        "gene_names_refseq": "ERR1; ERRalpha; ERRa; ESRL1; ESRRA; NR3B1",
        "protein_names_uniprotkb": "Steroid hormone receptor ERR1; ERR-alpha; Estrogen receptor-like 1; Estrogen-related receptor alpha; Nuclear receptor subfamily 3 group B member 1",
        "protein_names_refseq": "ERR-alpha; estrogen receptor-like 1; estrogen-related nuclear receptor alpha; nuclear receptor subfamily 3 group B member 1; steroid hormone receptor ERR1 isoform 1; steroid hormone receptor ERR1",
        "tax_id": 9606,
        "disease": "azoospermia (Disease Ontology:DOID:14227); cancer (Disease Ontology:DOID:162); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:2101);  (R-HSA-1989781);  (R-HSA-2151201);  (R-HSA-383280);  (R-HSA-8939902)",
        "pathway_count": 5,
        "publication_count": 144,
        "publication_id_list": "10215629;10235266;10412986;10542397;10572046;10643692;10713165;10777541;10911365;11237011;11267664;11340167;11809803;11865025;12000792;12118000;12177166;12374852;12505311;12522104;12563009;12582161;12738770;12745923;12923053;15067378;15130092;15175151;15302935;15337744;15635043;15684387;15703179;15896744;16079181;16079853;16115867;16150865;16380219;16421188;16728642;16751179;16788062;16890199;16908542;16911507;16972786;17031457;17437997;17676930;17715127;17786208;17923681;18063693;18215119;18343819;18441008;18452278;18540824;18541707;18669648;18680753;18719978;18848529;19001277;19088433;19356719;19413330;19417006;19710929;19934321;19951946;20068231;20110263;20484414;21190936;21931630;22422618;23403054;23836911;23943595;24196956;24366607;24715725;25260729;25576301;25755297;25772364;25892735;26091038;26154972;26778333;27600516;27846572;27920218;28228285;28832583;29557506;29632046;29769354;29786170;29789417;30315122;30429286;31844290;32157095;32387766;32488085;32502341;3267207;32938616;32983136;33141586;33298915;33592498;33912179;33968037;34171305;34211107;34932366;35051231;35318648;35580925;37938771;38393411;38447458;38937602;39231208;39450559;7629110;7685352;7799916;7892212;8108407;8224847;8333869;8621448;8647822;9012850;9178750;9271417;9286700;9653119;9748239",
        "class_list": "",
        "function": "Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; ERRalpha and ERRgamma coordinate expression of genes associated with Alzheimer's disease, inhibiting DKK1 to suppress tau phosphorylation., [RefSeq, PubMed]; Estrogen related receptor alpha: Potential modulator of age-related macular degeneration. Review article, [RefSeq, PubMed]; Estrogen-related receptor alpha (ERRalpha) promotes the migration, invasion and angiogenesis of breast cancer stem cell-like cells. Publication Status: Online-Only, [RefSeq, PubMed]; Estrogen-related receptor alpha promotes thyroid tumor cell survival via a tumor subtype-specific regulation of target gene networks., [RefSeq, PubMed]; Silencing of ERRalpha gene represses cell proliferation and induces apoptosis in human skin fibroblasts., [RefSeq, PubMed]; The protein encoded by this gene is a nuclear receptor that is most closely related to the estrogen receptor. This protein acts as a site-specific transcription factor and interacts with members of the PGC-1 family of transcription cofactors to regulate the expression of most genes involved in cellular energy production as well as in the process of mitochondrial biogenesis. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq, Jun 2019]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 22,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14514",
        "ec_number_list": "",
        "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0003707 nuclear steroid receptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001650 fibrillar center;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0010468 regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 14.5,
        "record_id": "P11474-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UQ16-1",
        "uniprot_id": "DYN3_HUMAN",
        "mass": 97746.0,
        "length": 869,
        "protein_name": "Dynamin-3",
        "gene_name": "DNM3",
        "organism": "Human",
        "refseq_name": "dynamin-3 isoform b",
        "refseq_ac": "NP_001129599",
        "gene_names_uniprotkb": "DNM3; KIAA0820",
        "gene_names_refseq": "DNM3; Dyna III",
        "protein_names_uniprotkb": "Dynamin-3; 3.6.5.5; Dynamin, testicular; T-dynamin",
        "protein_names_refseq": "T-dynamin; dynamin family member; dynamin, testicular; dynamin-3 isoform b",
        "tax_id": 9606,
        "disease": "collagen disease (Disease Ontology:DOID:854)",
        "pathway": " (hsa:26052);  (R-HSA-166016);  (R-HSA-177504);  (R-HSA-2132295);  (R-HSA-437239);  (R-HSA-8856828)",
        "pathway_count": 6,
        "publication_count": 263,
        "publication_id_list": "10036229;10064083;10072072;10201950;10480952;10535736;10540230;10542231;10559856;10559861;10559924;10593899;10608864;10625686;10631941;10631952;10639150;10747093;10748235;10766823;10804209;10809954;10818153;11082044;11157096;11230166;11231140;11237011;11239472;11274165;11470803;11516654;11517213;11529500;11532990;11577110;11684289;11790530;11813165;11853874;11877457;11877461;11889126;12057195;12078484;12082080;12198549;12213833;12447393;12471095;12742663;12748383;12847086;12942088;12952949;14555962;14556004;14581451;14617351;14622578;14622579;14731593;15252009;15260957;15276183;15318165;15339664;15502812;15502813;15596121;15649145;15703209;15749704;15802264;15895077;15911768;15916959;16103228;16181339;16215232;16242130;16303959;16326391;16330023;16410077;16467847;16516836;16618111;16707488;16751103;16757566;16798879;16824007;16880396;16903783;17018281;17035995;17142755;17158794;17283181;17494869;17512409;17540576;17609109;17681954;17762867;17765681;17978091;18046453;18093523;18160138;18222170;18233961;18292509;18297073;18388313;18478542;1847920;18790740;18981233;19092055;19278660;19287005;19296720;19458185;19536138;1956401;19564404;19575674;19603039;19696796;19713939;19776351;19809571;20033059;20059951;20211604;20231386;20428113;20448150;20826345;20946875;21116285;2115402;21187331;2121367;21278753;21316588;21441454;21445324;21482805;21499258;21613550;21779028;21841790;21883765;2190094;21927000;21927001;21962517;22078883;22099461;22158869;22233676;22424782;22484487;22505844;22815487;22863004;23297414;23536704;23823722;23861397;23891661;2391366;24130457;24186068;2448316;24581490;2462607;24715725;2477488;24789820;24966051;25107275;25303366;25341920;25825441;26042225;26154972;26403691;28228285;28832583;28834231;29493099;29557506;30340792;31844290;32157095;32387766;32502341;32573516;32873436;32897882;32938616;32983136;33141586;33537174;33622874;33691108;33912179;33968037;34509645;34561969;34932366;35051231;35251023;35318648;3537192;35580925;36010968;36241641;36528667;37938771;6146630;7481823;7493978;7592972;7650016;7667286;7877694;8046351;8134367;8145819;8148318;8313912;8397411;8415765;8524399;8552632;8642258;8687433;8849454;8909537;8939989;8947036;9075930;9092476;9100026;9202021;9311912;9312039;9427626;9428629;9497313;9539769;9545226;9606180;9635431;9651214;9665271;9721721;9736607",
        "class_list": "",
        "function": "Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2 Parkinson's disease., [RefSeq, PubMed]; Integrated multi-omic analysis of low-grade ovarian serous carcinoma collected from short and long-term survivors. Publication Status: Online-Only, [RefSeq, PubMed]; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TBX15 rs98422, DNM3 rs1011731, RAD51B rs8017304, and rs2588809 Gene Polymorphisms and Associations With Pituitary Adenoma., [RefSeq, PubMed]; The Expression of Dynamin 1, 2, and 3 in Human Hepatocellular Carcinoma and Patient Prognosis. Publication Status: Online-Only, [RefSeq, PubMed]; There is no evidence of an association between DNM3 variants and age at onset in idiopathic Parkinson's disease., [RefSeq, PubMed]; This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A9Z1Y1;O14982;O95555;Q1MTM8;Q5W129;Q6P2G1;Q9H0P3;Q9H548;Q9NQ68;Q9NQN6",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;2.7.11.1;3.1.3.-;3.6.1.5;2.7.10.1;3.6.4.10;5.6.1.6;3.1.4.11;2.3.2.27;3.6.1.-;3.6.4.-;3.6.5.4;3.1.3.86;3.1.3.56;3.1.3.36;3.6.-.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine",
        "go_biological_process": "GO:0006897 endocytosis;GO:0046847 filopodium assembly;GO:0007416 synapse assembly;GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 26.4,
        "record_id": "Q9UQ16-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "B3EWF7-1",
        "uniprot_id": "EP2A2_HUMAN",
        "mass": 35169.0,
        "length": 344,
        "protein_name": "Laforin, isoform 9",
        "gene_name": "EPM2A",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "EPM2A",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Laforin, isoform 9",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "Lafora disease 1 (Disease Ontology:DOID:0070660); Lafora disease (Disease Ontology:DOID:3534); progressive myoclonus epilepsy (Disease Ontology:DOID:891)",
        "pathway": " (hsa:7957);  (R-HSA-3322077);  (R-HSA-3785653)",
        "pathway_count": 3,
        "publication_count": 62,
        "publication_id_list": "11001928;11175283;11220751;11237011;11735300;11739371;11883934;12019207;12560877;12782127;12915448;12958597;14532330;14706656;14722920;15009235;15102711;15930137;16021330;16901901;16971387;17908927;18040046;18070875;18311786;18617530;19036738;19542233;19699667;20357282;20453062;20538597;21356517;21728993;22036712;22248338;22815132;22961547;23624058;23663739;23922729;25416783;25538239;25544560;26216881;26231210;29242379;29393594;29557506;29786170;33141586;35051231;4829444;5348606;5427280;7902568;8613547;8631325;9346895;9691087;9771710;9931343",
        "class_list": "glycogene",
        "function": "Does not bind to glycogen (PubMed:18617530). Lacks phosphatase activity and might function as a dominant-negative regulator for the phosphatase activity of isoform 1 and isoform 7 (PubMed:18617530, PubMed:22036712)., [UniProtKB, PubMed, PubMed]; Has phosphatase activity (in vitro)., [UniProtKB, PubMed]; Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates (PubMed:16901901, PubMed:23922729, PubMed:25538239, PubMed:25544560, PubMed:26231210). Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro) (PubMed:11001928, PubMed:11220751, PubMed:11739371, PubMed:14532330, PubMed:14722920, PubMed:16971387, PubMed:18617530, PubMed:22036712, PubMed:23922729). Has been shown to dephosphorylate MAPT (By similarity). Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin (PubMed:23922729). Also promotes proteasome-independent protein degradation through the macroautophagy pathway (PubMed:20453062)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 28,
        "reported_glycation": 0,
        "reported_snv": 50,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.21;3.1.3.18;3.1.3.-;2.4.1.186;2.4.1.11;3.1.3.5;3.1.3.2;2.7.10.1;3.1.3.67;3.1.3.53;2.3.2.27;3.1.3.52;3.1.3.27;3.1.3.86;3.1.3.36;3.1.3.74",
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046983 protein dimerization activity;GO:0004722 protein serine/threonine phosphatase activity;GO:0030246 carbohydrate binding;GO:0004373 alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0016311 dephosphorylation;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0005977 glycogen metabolic process;GO:0006914 autophagy;GO:0005978 glycogen biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "B3EWF7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P00742-1",
        "uniprot_id": "FA10_HUMAN",
        "mass": 54732.0,
        "length": 488,
        "protein_name": "Coagulation factor X",
        "gene_name": "F10",
        "organism": "Human",
        "refseq_name": "coagulation factor X isoform 1 preproprotein",
        "refseq_ac": "NP_000495",
        "gene_names_uniprotkb": "F10",
        "gene_names_refseq": "F10; FXA; FX",
        "protein_names_uniprotkb": "Coagulation factor X; 3.4.21.6; Stuart factor; Stuart-Prower factor",
        "protein_names_refseq": "Stuart-Prower factor; coagulation factor X isoform 1 preproprotein; factor Xa; prothrombinase",
        "tax_id": 9606,
        "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); epilepsy (Disease Ontology:DOID:1826); factor X deficiency (Disease Ontology:DOID:2222); hyperhomocysteinemia (Disease Ontology:DOID:9279)",
        "pathway": " (hsa:2159);  (R-HSA-159740);  (R-HSA-159763);  (R-HSA-159782);  (R-HSA-9672383);  (R-HSA-9672396);  (R-HSA-9673202);  (R-HSA-9769735);  (R-HSA-9769739);  (R-HSA-9769743)",
        "pathway_count": 10,
        "publication_count": 181,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10026158;10068650;10391209;10468875;10468877;10739379;10746568;10917896;11035113;11237011;11238108;11248282;11252894;11342438;11513608;11728527;11833835;11986214;12052963;12091341;12574802;12907439;12945883;1346975;14982929;15075089;15650540;16161994;1618828;16619025;16807644;17227710;17393015;17506785;17598008;17635713;18042685;18202198;1874730;1902434;1902833;19135706;19297154;1930190;1958666;1973167;19846852;1985698;20004170;2019570;2040636;20427285;2104832;2105717;2110473;21107324;21673107;21932952;22144186;22171320;22383955;22409427;2248955;22618708;22652793;2271516;22786881;22961984;23006890;23021219;2303434;23584533;23621622;23677006;23683607;2384594;24041930;24554904;2502206;2505252;25313940;2538457;25576301;25713144;25753038;2582420;25855704;26023895;2612918;26222694;26473492;2664828;2704749;271951;2738071;2790181;29223926;29419409;29437578;29557506;3011603;3017409;30459171;3052293;30568593;3082357;30918026;31003762;31133602;31262782;3129422;3134349;31439947;31844290;32488085;3275472;34019948;34502392;34831181;3524673;3527261;35738824;36951953;37024459;37074911;3733688;3744129;37469515;3768336;37726033;37842794;37925034;3863104;38742661;39002733;39528527;3965513;39880037;6323392;6334516;6438527;6587384;6871167;6967872;6980899;7499257;7620335;7669671;7727775;7756647;7803238;7860069;8144529;8148489;8243461;8336730;8338946;8355279;8473289;8529633;8530480;8578528;8598903;8626656;8639673;8639781;8845463;8910490;8920993;9218519;9427707;9459334;9469622;9607108;9618463;9774404;9780208;9834200;9888880",
        "class_list": "",
        "function": "Activated factor X stimulates atrial endothelial cells and tissues to promote remodelling responses through AT1R/NADPH oxidases/SGLT1/2., [RefSeq, PubMed]; Conformation of factor Xa in solution revealed by single-molecule spectroscopy., [RefSeq, PubMed]; Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection. Publication Status: Online-Only, [RefSeq, PubMed]; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (PubMed:22409427, PubMed:39880037). Factor Xa activates pro-inflammatory signaling pathways in a protease-activated receptor (PAR)-dependent manner (PubMed:24041930, PubMed:30568593, PubMed:34831181, PubMed:18202198). Up-regulates expression of protease-activated receptors (PARs) F2R, F2RL1 and F2RL2 in dermal microvascular endothelial cells (PubMed:35738824). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, in cardiac fibroblasts and umbilical vein endothelial cells in PAR-1/F2R-dependent manner (PubMed:30568593, PubMed:34831181). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2, IL6, TNF/TNF, IL-1beta/IL1B, IL8/CXCL8 and IL18, in endothelial cells and atrial tissues (PubMed:24041930, PubMed:35738824, PubMed:9780208). Induces expression of adhesion molecules, such as ICAM1, VCAM1 and SELE, in endothelial cells and atrial tissues (PubMed:24041930, PubMed:35738824, PubMed:9780208). Increases expression of phosphorylated ERK1/2 in dermal microvascular endothelial cells and atrial tissues (PubMed:24041930, PubMed:35738824). Triggers activation of the transcription factor NF-kappa-B in dermal microvascular endothelial cells and atrial tissues (PubMed:24041930, PubMed:35738824). Activates pro-inflammatory and pro-fibrotic responses in dermal fibroblasts and enhances wound healing probably via PAR-2/F2RL1-dependent mechanism (PubMed:18202198). Activates barrier protective signaling responses in endothelial cells in PAR-2/F2RL1-dependent manner; the activity depends on the cleavage of PAR-2/F2RL1 by factor Xa (PubMed:22409427). Up-regulates expression of plasminogen activator inhibitor 1 (SERPINE1) in atrial tissues (PubMed:24041930)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Five new F10 variants in hereditary factor x deficiency detected by high-throughput sequencing., [RefSeq, PubMed]; This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 2,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 12,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 13,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 13,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 10,
        "reported_phosphosites": 0,
        "reported_mutagensis": 14,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 35,
        "disease_count": 7,
        "glyco_site_count": 14,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14340",
        "ec_number_list": "3.4.21.5;3.4.21.22;3.4.21.6;3.4.21.21;3.4.21.75;4.1.1.90",
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005543 phospholipid binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0005796 Golgi lumen;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006508 proteolysis;GO:0030335 positive regulation of cell migration;GO:0007596 blood coagulation;GO:0032008 positive regulation of TOR signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 23.2,
        "record_id": "P00742-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O94855-1",
        "uniprot_id": "SC24D_HUMAN",
        "mass": 113010.0,
        "length": 1032,
        "protein_name": "Protein transport protein Sec24D",
        "gene_name": "SEC24D",
        "organism": "Human",
        "refseq_name": "protein transport protein Sec24D isoform 2",
        "refseq_ac": "NP_001304995",
        "gene_names_uniprotkb": "SEC24D; KIAA0755",
        "gene_names_refseq": "CLCRP2; SEC24D",
        "protein_names_uniprotkb": "Protein transport protein Sec24D; SEC24-related protein D",
        "protein_names_refseq": "SEC24 homolog D, COPII coat complex component; SEC24 related gene family, member D; SEC24-related protein D; protein transport protein Sec24D isoform 2; protein transport protein Sec24D",
        "tax_id": 9606,
        "disease": "Cole-Carpenter syndrome (Disease Ontology:DOID:0060438)",
        "pathway": " (hsa:9871);  (R-HSA-1655829);  (R-HSA-204005);  (R-HSA-2132295);  (R-HSA-5694530);  (R-HSA-9705671);  (R-HSA-983170)",
        "pathway_count": 7,
        "publication_count": 326,
        "publication_id_list": "10.1101/2023.09.13.557529;10036229;10064069;10064083;10072072;10329445;10397761;10428864;10445031;10480952;10540230;10559958;10559959;10593899;10600378;10631941;10631952;10639150;10644685;10652252;10679020;10747087;10748235;10777614;10788476;10805775;10809954;10825291;10903204;10982397;11035026;11160214;11163199;11237011;11283257;11285137;11306556;11514579;11529500;11684289;11790530;11813165;11853874;11927603;12019269;12070132;12078484;12198549;12235121;12237308;12436109;12436110;12645939;12692549;12742663;12748383;12759408;14645851;14681859;14718384;14731593;15037235;15208624;15286279;15550381;15749704;15911768;15927284;16129679;16181339;16242130;16303754;16465444;16473882;16495487;16618111;16624868;16824007;16912714;17005010;17010120;17038314;17056546;17088086;17142755;17192411;17210573;17283181;17287728;17316621;17449569;17499046;17562788;17607000;17656363;17684057;18025080;18046453;18283111;18287528;18292509;18452278;18843296;19119025;19164740;19193869;19261456;19265014;19269366;19342655;19361863;19426129;1956401;19564404;19566487;19575639;19638414;19656848;19851281;2038058;20427317;20477988;20533886;20545907;20605430;20679433;20805473;20966969;21050182;21116285;2121367;21441454;21478858;21525241;21532587;21689688;21878990;2190094;22013193;22157747;22299025;22675024;22941947;23186163;23301498;23378591;23479643;23481700;23698585;23852824;23864707;2391366;24119662;24405750;2450918;24714562;24917561;25202031;25406594;25418920;25492864;25576301;25586378;25619252;25619253;25683121;26758079;26992070;27551091;27802162;27846572;27869121;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29493099;29557506;29786170;30315122;30397120;30429286;30524438;31154438;31217245;31530632;31844290;31848261;31850239;31875875;32119511;32157095;32161166;32353859;32357974;32387766;32428392;32502341;32589897;32726803;32728199;32897882;32938616;32953130;32979938;32983136;33024073;33060197;33097660;33110251;33214551;33298915;33349665;33360543;33372174;33372854;33392160;33396605;33440148;33479219;33495715;33514628;33567255;33592498;33717175;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33912179;33963333;33968037;33981976;33989516;33990585;34019948;34021074;34054808;34084167;34110168;34142147;34166398;34185709;34239064;34290717;34341353;34357683;34375313;34400613;34439781;34452305;34471099;34502139;34561969;34597346;34725712;34932366;35051231;35102342;35138101;35154160;35289036;35318648;35580925;35643212;36010968;36241641;36284347;37051252;37676273;37938771;38665916;39302247;39531497;39534244;7481823;7592972;7642652;7650016;7667286;7876241;8046351;8134367;8145819;8148318;8156598;8221884;8313912;8342042;8397411;8415765;8620540;8642258;8663406;8674110;8687433;8849454;8909537;8939989;8947036;9075930;9094723;9150144;9177194;9202021;9307973;9311912;9312039;9395526;9472029;9488713;9497313;9539769;9545226;9605141;9606180;9634703;9647643;9659902",
        "class_list": "",
        "function": "Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296)., [UniProtKB, PubMed, PubMed, PubMed]; Concentrative endoplasmic reticulum-export is contingent on a direct interaction of GAT1 with Sec24D., [RefSeq, PubMed]; Rare variant modifier analysis identifies variants in SEC24D associated with orofacial cleft subtypes., [RefSeq, PubMed]; The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. This gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration. Mutations in this gene have been associated with Cole-Carpenter syndrome, a disorder affecting bone formation, resulting in craniofacial malformations and bones that break easily. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]., [RefSeq]; Three mutant SEC24D alleles in a rare autosomal-recessively inherited skeletal disorder characterized by pre- and postnatal bone fragility, skull ossification defects, craniofacial dysmorphism, and short stature, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 35,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 1,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IYI7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000149 SNARE binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0012507 ER to Golgi transport vesicle membrane;GO:0070971 endoplasmic reticulum exit site",
        "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport;GO:0070863 positive regulation of protein exit from endoplasmic reticulum",
        "synthesized_glycan_count": 0,
        "hit_score": 33.9,
        "record_id": "O94855-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60427-1",
        "uniprot_id": "FADS1_HUMAN",
        "mass": 51964.0,
        "length": 444,
        "protein_name": "Acyl-CoA (8-3)-desaturase",
        "gene_name": "FADS1",
        "organism": "Human",
        "refseq_name": "acyl-CoA (8-3)-desaturase isoform X2",
        "refseq_ac": "XP_047282891",
        "gene_names_uniprotkb": "FADS1; FADSD5",
        "gene_names_refseq": "D5D; FADS1; FADS6; FADSD5; LLCDL1; TU12",
        "protein_names_uniprotkb": "Acyl-CoA (8-3)-desaturase; 1.14.19.44; D5D; Delta(5) desaturase; Delta(5) fatty acid desaturase; Delta-5 desaturase; Fatty acid desaturase 1",
        "protein_names_refseq": "acyl-CoA (8-3)-desaturase isoform X2",
        "tax_id": 9606,
        "disease": "hypertension (Disease Ontology:DOID:10763); alcohol use disorder (Disease Ontology:DOID:1574); lipid metabolism disorder (Disease Ontology:DOID:3146); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:3992);  (R-HSA-1989781);  (R-HSA-2046105);  (R-HSA-2046106)",
        "pathway_count": 4,
        "publication_count": 110,
        "publication_id_list": "10601301;10769175;10777541;10860662;10899997;10970790;11237011;11267664;11500517;11734571;11988075;12118000;12177166;12323085;12323090;12505311;12562861;12582161;12713571;12716664;12897190;1346092;14636670;15067378;15130092;15635043;16380219;16972786;1834642;18538142;18540824;18719978;18848529;19056654;19088433;19710929;19934321;20110263;22619218;23481700;24196956;24714562;24715725;25576301;25732826;25892735;26154972;26728094;26992070;27600516;27846572;27893789;27920218;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29557506;29769354;29786170;30315122;30484775;30524438;30833945;31154438;31217245;31844290;31848261;32157095;32161166;32357974;32387766;32897882;32938616;33141586;33298915;33392160;33717175;33912179;33936100;33968037;34171305;34211107;34509645;34932366;35051231;35580925;36010968;36215666;36241641;36284347;36581221;38665916;5411545;7061494;7685352;7892212;8096621;8609415;8647822;8656081;8832760;9012850;9684854;9704073;9732298;9748239",
        "class_list": "",
        "function": "Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively (PubMed:10601301, PubMed:10769175). As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (By similarity). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K0I7;B2RAI0;Q53GM5;Q8N3A6;Q8NCC7;Q8NCG0;Q96I39;Q96SV3;Q96T10;Q9NRP8;Q9NYX1",
        "ec_number_list": "1.14.19.44;2.3.1.48;3.6.4.-;2.1.1.319;2.3.1.-;2.1.1.-;3.1.13.1;5.6.2.6;3.6.4.13",
        "go_molecular_function": "GO:0000248 C-5 sterol desaturase activity;GO:0045485 omega-6 fatty acid desaturase activity;GO:0016491 oxidoreductase activity;GO:0016213 acyl-CoA 6-desaturase activity;GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane;GO:0043231 intracellular membrane-bounded organelle;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0046456 icosanoid biosynthetic process;GO:0006629 lipid metabolic process;GO:0007267 cell-cell signaling;GO:0036109 alpha-linolenic acid metabolic process;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 11.3,
        "record_id": "O60427-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5RHP9-1",
        "uniprot_id": "ERIC3_HUMAN",
        "mass": 168466.0,
        "length": 1530,
        "protein_name": "Glutamate-rich protein 3",
        "gene_name": "ERICH3",
        "organism": "Human",
        "refseq_name": "glutamate-rich protein 3",
        "refseq_ac": "NP_001002912",
        "gene_names_uniprotkb": "ERICH3; C1orf173",
        "gene_names_refseq": "C1orf173; ERICH3",
        "protein_names_uniprotkb": "Glutamate-rich protein 3",
        "protein_names_refseq": "RP11-653A5.1; glutamate-rich protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:127254)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "11237011;23481700;24029068;24715725;28228285;28282151;28832583;29557506;30379171;31712586;32897882;32938616;33230203;33298915;33912179;33968037;35051231;35660571;35878676",
        "class_list": "",
        "function": "Component of the primary cilium that controls cilium formation and length (PubMed:31712586). May function within retrograde intraflagellar transport (IFT)-associated pathways to remove signaling proteins from primary cilia (PubMed:31712586). Also involved in neuronal vesicle biogenesis and neurotransmitter vesicular function (PubMed:33230203)., [UniProtKB, PubMed, PubMed]; Enterovirus 71 VP1 promotes 5-HT release by upregulating the expression of ERICH3 and methyltransferase ZC3H13., [RefSeq, PubMed]; The ERICH3 rs11580409 polymorphism is associated with 6-month antidepressant response in depressed patients., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 32,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q68DL8;Q6GMR8;Q6ZSF9;Q8ND41",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium;GO:0005930 axoneme;GO:0097730 non-motile cilium",
        "go_biological_process": "GO:0060271 cilium assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q5RHP9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6V0I7-1",
        "uniprot_id": "FAT4_HUMAN",
        "mass": 542687.0,
        "length": 4981,
        "protein_name": "Protocadherin Fat 4",
        "gene_name": "FAT4",
        "organism": "Human",
        "refseq_name": "protocadherin Fat 4 isoform 2 precursor",
        "refseq_ac": "NP_001278214",
        "gene_names_uniprotkb": "FAT4; CDHF14; FATJ; Nbla00548",
        "gene_names_refseq": "CDHF14; CDHR11; FAT-J; FAT4; FATJ; HKLLS2; NBLA00548; VMLDS2",
        "protein_names_uniprotkb": "Protocadherin Fat 4; Cadherin family member 14; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J; hFat4",
        "protein_names_refseq": "FAT tumor suppressor homolog 4; cadherin family member 14; cadherin-related family member 11; fat-like cadherin protein FAT-J; protocadherin Fat 4 isoform 2 precursor; protocadherin Fat 4; putative protein product of Nbla00548",
        "tax_id": 9606,
        "disease": "Hennekam syndrome (Disease Ontology:DOID:0060366); Van Maldergem syndrome 2 (Disease Ontology:DOID:0080586); neurodegenerative disease (Disease Ontology:DOID:1289); carcinoma (Disease Ontology:DOID:305); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:79633)",
        "pathway_count": 1,
        "publication_count": 56,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;12880961;15003449;15345747;16865240;18452278;19048595;20934997;23090970;23319386;23481700;24056717;24190977;24715725;24913602;27600516;27862975;28467828;28904123;29242379;29393594;29508533;29557506;30429286;30620550;31154438;31217245;31844290;31848261;32157095;32162841;32387766;32502341;32938616;33043033;33392160;33592498;33912179;33968037;33981976;34087483;35051231;35494241;35580925;36010968;36241641;36581221;36797229;36811800;37074911;37751246;38055646;38253038;38665916;39178518",
        "class_list": "",
        "function": "Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity)., [UniProtKB]; FAT4 loss initiates hepatocarcinogenesis through the switching of canonical to noncanonical WNT signaling pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Fat4 may be a breast tumor suppressor gene, [RefSeq, PubMed]; IL-32 aggravates metabolic disturbance in human nucleus pulposus cells by activating FAT4-mediated Hippo/YAP signaling. Erratum:[Int Immunopharmacol. 2024 Dec 5;142(Pt A):113049. doi: 10.1016/j.intimp.2024.113049. PMID: 39294029], [RefSeq, PubMed]; Identification of FAT4 as a positive prognostic biomarker in DLBCL by comprehensive genomic analysis., [RefSeq, PubMed]; Prognostic Impact of FSTL3, ADAM12, and FAT4 in Patients of Colon Cancer: Clinicopathologic Study., [RefSeq, PubMed]; Structure of the planar cell polarity cadherins Fat4 and Dachsous1. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP). Studies in mice suggest that loss of PCP signaling may cause cystic kidney disease, and mutations in this gene have been associated with Van Maldergem Syndrome 2. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Mar 2014]., [RefSeq]",
        "predicted_glycosites": 24,
        "predicted_n_glycosites": 22,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 16,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 15,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 16,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 16,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 283,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 13,
        "disease_count": 5,
        "glyco_site_count": 45,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5Z6;B5MDG4;Q3LIA6;Q8TCK7;Q9H5T6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0070062 extracellular exosome;GO:0045177 apical part of cell",
        "go_biological_process": "GO:0007409 axonogenesis;GO:0030855 epithelial cell differentiation;GO:0021987 cerebral cortex development;GO:0035329 hippo signaling;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules",
        "synthesized_glycan_count": 0,
        "hit_score": 9.1,
        "record_id": "Q6V0I7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q99623-1",
        "uniprot_id": "PHB2_HUMAN",
        "mass": 33296.0,
        "length": 299,
        "protein_name": "Prohibitin-2",
        "gene_name": "PHB2",
        "organism": "Human",
        "refseq_name": "prohibitin-2 isoform 1",
        "refseq_ac": "NP_001138303",
        "gene_names_uniprotkb": "PHB2; BAP; REA",
        "gene_names_refseq": "BAP; BCAP37; Bap37; PHB2; PNAS-141; REA; hBAP; p22",
        "protein_names_uniprotkb": "Prohibitin-2; B-cell receptor-associated protein BAP37; D-prohibitin; Repressor of estrogen receptor activity",
        "protein_names_refseq": "B cell receptor associated protein 37; B-cell associated protein; B-cell receptor-associated protein BAP37; D-prohibitin; prohibitin-2 isoform 1; repressor of estrogen receptor activity",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11331);  (R-HSA-8949664);  (R-HSA-9840373)",
        "pathway_count": 3,
        "publication_count": 125,
        "publication_id_list": "10.1101/2023.09.13.557529;10359819;10931946;11237011;11302691;14654843;15592455;17565718;18691976;19496786;19608861;19640993;19906925;20959514;21328542;21689744;21746876;22997079;23186163;23481700;24003225;24522204;24714562;24715725;25418920;25433032;25502872;25576301;25645385;25904163;26154972;26728094;26811146;26923599;26992070;27452731;27642048;27737933;27846572;27862975;27920218;28017329;28063628;28218747;28228285;28555617;28832583;28834231;28855257;28904123;29242379;29393594;29508533;29557506;29632046;29632711;29774024;29786170;30315122;30379171;30410026;30429286;30444036;30484775;30833945;31154438;31165762;31217245;31222486;31522117;31611695;31844290;31848261;32132706;32132707;32157095;32161166;32276428;32350084;32387766;32502341;32870666;32938616;32983136;33141586;33214551;33298915;33592498;33691108;33717175;33820826;33912179;33936100;33968037;34171305;34211107;34357683;34561969;34725712;34932366;35051231;35154160;35163244;35251023;35388015;35561310;35580925;36010968;36215666;36241641;36284347;37217939;37327776;37550454;37587393;37796696;37938771;38142736;38200519;38665916;39181433;39990658;40596516;41398051;9074930",
        "class_list": "",
        "function": "(Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection., [UniProtKB, PubMed]; Blockade of the lncRNA-PART1-PHB2 axis confers resistance to PARP inhibitor and promotes cellular senescence in ovarian cancer., [RefSeq, PubMed]; In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan. The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner. Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity. Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In the mitochondria, together with PHB1, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration (PubMed:11302691, PubMed:20959514). Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:11302691, PubMed:20959514). Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity)., [UniProtKB, UniProtKB, PubMed]; In the nucleus, serves as transcriptional co-regulator. Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In the plasma membrane, is involved in IGFBP6-induced cell migration (PubMed:24003225). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity)., [UniProtKB, UniProtKB, PubMed]; In the plasma membrane, is involved in IGFBP6-induced cell migration. Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Prohibitin 2: A key regulator of cell function. Review article, [RefSeq, PubMed]; Prohibitin2/PHB2, Transcriptionally Regulated by GABPA, Inhibits Cell Growth via PRKN/Parkin-dependent Mitophagy in Endometriosis., [RefSeq, PubMed]; Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The Role of Prohibitin-2 in Diseases. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DP75;Q2YDA4;Q7KYU3;Q92978",
        "ec_number_list": "",
        "go_molecular_function": "GO:0033218 amide binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0030331 nuclear estrogen receptor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016477 cell migration;GO:0043066 negative regulation of apoptotic process;GO:0070374 positive regulation of ERK1 and ERK2 cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 13.3,
        "record_id": "Q99623-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UN36-1",
        "uniprot_id": "NDRG2_HUMAN",
        "mass": 40798.0,
        "length": 371,
        "protein_name": "Protein NDRG2",
        "gene_name": "NDRG2",
        "organism": "Human",
        "refseq_name": "protein NDRG2 isoform c",
        "refseq_ac": "NP_001269140",
        "gene_names_uniprotkb": "NDRG2; KIAA1248; SYLD",
        "gene_names_refseq": "NDRG2; SYLD",
        "protein_names_uniprotkb": "Protein NDRG2; N-myc downstream-regulated gene 2 protein; Protein Syld709613",
        "protein_names_refseq": "N-myc downstream regulator 2; N-myc downstream-regulated gene 2 protein; NDR1-related protein NDR2; cytoplasmic protein Ndr1; protein NDRG2 isoform c; protein NDRG2; syld709613 protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57447)",
        "pathway_count": 1,
        "publication_count": 39,
        "publication_id_list": "11230166;11237011;11352569;11936845;12845671;14572661;15207261;15461589;15526377;16103061;18077418;18669648;19413330;19562805;19651622;19664994;19690332;20166139;21247902;22223895;23186163;23558861;24275569;26500492;28141794;28953854;29557506;29786170;31844290;32157095;32350084;33912179;35251023;35580925;36651243;36989575;38241776;38474089;38842567",
        "class_list": "",
        "function": "Cloning and expression of the gene; highly expressed in adult skeletal muscle and brain, [RefSeq, PubMed]; Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Down-Regulation of N-Myc downstream-regulated gene 2 is associated with glioblastoma Erratum:[Int J Cancer. 2003 Oct 10;106(6):984], [RefSeq, PubMed]; Inhibition of PRMT5/MEP50 Arginine Methyltransferase Activity Causes Cancer Vulnerability in NDRG2[low] Adult T-Cell Leukemia/Lymphoma. Publication Status: Online-Only, [RefSeq, PubMed]; Low NDRG2, regulated by the MYC/MIZ-1 complex and methylation, predicts poor outcomes in DLBCL patients., [RefSeq, PubMed]; ROS promote hyper-methylation of NDRG2 promoters in a DNMTS-dependent manner: Contributes to the progression of renal fibrosis., [RefSeq, PubMed]; The effect of p53 on the activity of NRF2 and NDRG2 genes through apoptotic pathway in IDH-wildtype glioblastoma., [RefSeq, PubMed]; This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]., [RefSeq]; [NDRG2 inhibits tumorigenesis of hepatocellular carcinoma by regulating metabolism of phospholipids and triglyceride: a metabonomic analysis]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 22,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "diagnostic",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KUE3;B4DE86;B7WP11;B7WPD5;D3DS07;D3DS10;Q567T1;Q68DW2;Q86U08;Q86U46;Q96FD3;Q96FT0;Q96JU0;Q96PN0;Q9BQH5;Q9ULH2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030426 growth cone",
        "go_biological_process": "GO:0007165 signal transduction;GO:0030154 cell differentiation;GO:0021762 substantia nigra development;GO:0016055 Wnt signaling pathway;GO:0007399 nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q9UN36-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y3R0-1",
        "uniprot_id": "GRIP1_HUMAN",
        "mass": 122422.0,
        "length": 1128,
        "protein_name": "Glutamate receptor-interacting protein 1",
        "gene_name": "GRIP1",
        "organism": "Human",
        "refseq_name": "glutamate receptor-interacting protein 1 isoform 2",
        "refseq_ac": "NP_001171545",
        "gene_names_uniprotkb": "GRIP1",
        "gene_names_refseq": "FRASRS3; GRIP1; GRIP",
        "protein_names_uniprotkb": "Glutamate receptor-interacting protein 1; GRIP-1",
        "protein_names_refseq": "glutamate receptor-interacting protein 1 isoform 2",
        "tax_id": 9606,
        "disease": "recessive dystrophic epidermolysis bullosa (Disease Ontology:DOID:0060642); Fraser syndrome (Disease Ontology:DOID:0090001); Fraser syndrome 3 (Disease Ontology:DOID:0111406); clubfoot (Disease Ontology:DOID:11836)",
        "pathway": " (hsa:23426);  (R-HSA-416993)",
        "pathway_count": 2,
        "publication_count": 25,
        "publication_id_list": "10197531;11237011;11641419;12011465;15226318;16055064;22510445;23271734;24488492;28832583;29242379;29557506;30524438;30620550;30779550;31844290;31848261;32157095;32938616;33298915;33912179;33968037;34509645;35051231;38253038",
        "class_list": "",
        "function": "After regulated endocytosis, binding to GRIP/ABP stabilizes the internalized receptors in an intracellular pool and prevents them from being recycled back to the plasma membrane or entering a degradative pathway., [RefSeq, PubMed]; GRIP1c 4-7 plays a role not only in glutamatergic synapses but also in GABAergic synapses, [RefSeq, PubMed]; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 51,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JT59;Q1RLM0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008013 beta-catenin binding;GO:0030159 signaling receptor complex adaptor activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0043204 perikaryon",
        "go_biological_process": "GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0035556 intracellular signal transduction;GO:0150012 positive regulation of neuron projection arborization",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "Q9Y3R0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UL40-1",
        "uniprot_id": "ZN346_HUMAN",
        "mass": 32933.0,
        "length": 294,
        "protein_name": "Zinc finger protein 346",
        "gene_name": "ZNF346",
        "organism": "Human",
        "refseq_name": "zinc finger protein 346 isoform b",
        "refseq_ac": "NP_001295142",
        "gene_names_uniprotkb": "ZNF346; JAZ",
        "gene_names_refseq": "JAZ; ZNF346; Zfp346",
        "protein_names_uniprotkb": "Zinc finger protein 346; Just another zinc finger protein",
        "protein_names_refseq": "double-stranded RNA-binding zinc finger protein JAZ; just another zinc finger protein; zinc finger protein 346 isoform b",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23567)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "10488071;11237011;15254228;21715977;23301498;24521053;25576301;25880248;26992070;28431233;28832583;28904123;29242379;31844290;32157095;32357974;33141586;33592498;33717175;35580925;36834567;37217939;38665916",
        "class_list": "",
        "function": "Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (PubMed:24521053). May bind to specific miRNA hairpins (PubMed:28431233)., [UniProtKB, PubMed, PubMed]; JAZ directly binds E2F1 in vitro in a dsRNA-independent manner, and JAZ's dsRNA binding ZF domains, which are necessary for localizing JAZ to the nucleus, are required for repression of transcriptional activity in vivo., [RefSeq, PubMed]; JAZ is exported by exportin-5 but translocates back into nuclei by a facilitated diffusion mechanism, [RefSeq, PubMed]; The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]; ZNF385A and ZNF346 Serve as Prognostic Biomarkers Associated with an Inflamed Immunosuppressive Tumor Microenvironment in Hepatocellular Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z367;Q68CV9;Q6ZMW1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0003725 double-stranded RNA binding;GO:0035198 miRNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q9UL40-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43759-1",
        "uniprot_id": "SNG1_HUMAN",
        "mass": 25456.0,
        "length": 233,
        "protein_name": "Synaptogyrin-1",
        "gene_name": "SYNGR1",
        "organism": "Human",
        "refseq_name": "synaptogyrin-1 isoform 1a",
        "refseq_ac": "NP_004702",
        "gene_names_uniprotkb": "SYNGR1",
        "gene_names_refseq": "SYNGR1",
        "protein_names_uniprotkb": "Synaptogyrin-1",
        "protein_names_refseq": "synaptogyrin-1 isoform 1a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9145);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 20,
        "publication_id_list": "11237011;14732601;17049558;17081065;18477386;21850230;23650620;29557506;30429286;31154438;31844290;32157095;32161166;32350084;32387766;32502341;34725712;36010968;8692836;9760194",
        "class_list": "",
        "function": "May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short-term and long-term synaptic plasticity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified. [provided by RefSeq, Jul 2008]., [RefSeq]; This research found a novel nonsense mutation (Trp27Ter) in exon 2 of the SYNGR1 gene in a family multiply affected with schizophrenia. And expressed in the brain., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NP69;A8K0E2;O43757;O43758;Q53Y02;Q96J56;Q9UGZ4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031594 neuromuscular junction;GO:0042470 melanosome",
        "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0045055 regulated exocytosis;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0048499 synaptic vesicle membrane organization",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "O43759-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95259-1",
        "uniprot_id": "KCNH1_HUMAN",
        "mass": 111423.0,
        "length": 989,
        "protein_name": "Voltage-gated delayed rectifier potassium channel KCNH1",
        "gene_name": "KCNH1",
        "organism": "Human",
        "refseq_name": "voltage-gated delayed rectifier potassium channel KCNH1 isoform 2",
        "refseq_ac": "NP_002229",
        "gene_names_uniprotkb": "KCNH1; EAG1; EAG",
        "gene_names_refseq": "EAG1; EAG; K(V)10.1; KCNH1; Kv10.1; TMBTS; ZLS1; h-eag; hEAG1; hEAG",
        "protein_names_uniprotkb": "Voltage-gated delayed rectifier potassium channel KCNH1; EAG channel 1; Ether-a-go-go potassium channel 1; Potassium voltage-gated channel subfamily H member 1; Voltage-gated potassium channel subunit Kv10.1; h-eag; hEAG1",
        "protein_names_refseq": "EAG channel 1; ether-a-go-go 1; ether-a-go-go potassium channel 1; ether-a-go-go, Drosophila, homolog of; potassium channel, voltage gated eag related subfamily H, member 1; potassium voltage-gated channel, subfamily H (eag-related), member 1; voltage-gated delayed rectifier potassium channel KCNH1 isoform 2; voltage-gated delayed rectifier potassium channel KCNH1; voltage-gated potassium channel subunit Kv10.1",
        "tax_id": 9606,
        "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); epilepsy (Disease Ontology:DOID:1826); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); Temple-Baraitser syndrome (MONDO:MONDO:0012735); Zimmermann-Laband syndrome 1 (MONDO:MONDO:0024526)",
        "pathway": " (hsa:3756);  (R-HSA-1296072)",
        "pathway_count": 2,
        "publication_count": 36,
        "publication_id_list": "10523298;10880439;11237011;11943152;20393197;20683999;21231794;21559285;22732247;22841712;23144454;23881642;24587194;25420144;25556795;25915598;27005320;27325704;27487920;27618660;28657654;29557506;30149017;30379171;33592498;33936100;34445705;35051231;35396394;35639255;36215666;36241641;36285361;38253038;38764027;9738473",
        "class_list": "",
        "function": "Hysteretic hERG channel gating current recorded at physiological temperature. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular Dynamics-Derived Pharmacophore Model Explaining the Nonselective Aspect of KV10.1 Pore Blockers. Publication Status: Online-Only, [RefSeq, PubMed]; Phenotypic and genetic analysis of children with unexplained neurodevelopmental delay and neurodevelopmental comorbidities in a Chinese cohort using trio-based whole-exome sequencing. Publication Status: Online-Only, [RefSeq, PubMed]; Phenotypic expansion of KCNH1-associated disorders to include isolated epilepsy and its associations with genotypes and molecular sub-regional locations., [RefSeq, PubMed]; Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate (PubMed:10880439, PubMed:11943152, PubMed:22732247, PubMed:25420144, PubMed:25556795, PubMed:25915598, PubMed:27005320, PubMed:27325704, PubMed:27618660, PubMed:30149017, PubMed:9738473). The activation kinetics depend on the prepulse potential and external divalent cation concentration (PubMed:11943152). With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation (PubMed:11943152). The time course of activation is biphasic with a fast and a slowly activating current component (PubMed:11943152). Activates at more positive membrane potentials and exhibit a steeper activation curve (PubMed:11943152). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Potassium Channel KCNH1 Activating Variants Cause Altered Functional and Morphological Ciliogenesis., [RefSeq, PubMed]; Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 57,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AQ26;O76035;Q14CL3",
        "ec_number_list": "1.8.-.-",
        "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:1902936 phosphatidylinositol bisphosphate binding;GO:0005516 calmodulin binding;GO:0005249 voltage-gated potassium channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0031901 early endosome membrane",
        "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0042391 regulation of membrane potential;GO:0071277 cellular response to calcium ion;GO:0006813 potassium ion transport;GO:0007520 myoblast fusion",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "O95259-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q02447-1",
        "uniprot_id": "SP3_HUMAN",
        "mass": 81925.0,
        "length": 781,
        "protein_name": "Transcription factor Sp3",
        "gene_name": "SP3",
        "organism": "Human",
        "refseq_name": "transcription factor Sp3 isoform 2",
        "refseq_ac": "NP_001017371",
        "gene_names_uniprotkb": "SP3",
        "gene_names_refseq": "SP3; SPR2",
        "protein_names_uniprotkb": "Transcription factor Sp3; SPR-2",
        "protein_names_refseq": "GC-binding transcription factor Sp3; specificity protein 3; transcription factor Sp3 isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6670);  (R-HSA-3232118)",
        "pathway_count": 2,
        "publication_count": 112,
        "publication_id_list": "10391891;11237011;11812829;12072434;12176973;12297010;12356736;12411611;12419227;12837748;1341900;1454515;15247228;15474306;15494207;15507434;15554904;16781829;17283066;17548428;17685427;18187045;18374648;18452278;18617891;18669648;19690332;19744555;20016603;20068231;20209145;20547755;21098080;21375726;21746878;21900752;21965678;22022399;23186163;23417673;23481700;24275569;24390485;24782567;24835590;25114211;25218447;25576301;25645385;25755297;25772364;26073453;26154972;26431879;26992070;27920218;27935866;28063628;28218747;28228285;28446606;28649982;28832583;28834231;28904123;29242379;29351928;29393594;29437277;29557506;29632046;29632711;29786170;30192525;30397120;30410026;31375868;31844290;32157095;32488085;32897882;32938616;32938750;32983136;33214551;33298915;33592498;33691108;33934099;33936100;33981976;34019948;34087483;34171305;34932366;35019687;35051231;35138101;35251023;35254053;35289036;35318648;35580925;36010968;36241641;36284347;38354174;38665916;38829410;39531497;40596516;9278495",
        "class_list": "",
        "function": "A novel Lnc408 maintains breast cancer stem cell stemness by recruiting SP3 to suppress CBY1 transcription and increasing nuclear beta-catenin levels. Publication Status: Online-Only, [RefSeq, PubMed]; Caspase-Mediated Cleavage of the Transcription Factor Sp3: Possible Relevance to Cancer and the Lytic Cycle of Kaposi's Sarcoma-Associated Herpesvirus., [RefSeq, PubMed]; Four isoforms derive from alternative translational start sites at positions 1, 37, 856, and 907; the transcriptional activity of all the Sp3 isoforms is regulated by SUMO modification, [RefSeq, PubMed]; SP3-induced Timeless transcription contributes to cell growth of lung adenocarcinoma cells. Publication Status: Online-Only, [RefSeq, PubMed]; Specificity protein 1/3 regulate T-cell acute lymphoblastic leukemia cell proliferation and apoptosis through beta-catenin by acting as targets of miR-495-3p., [RefSeq, PubMed]; This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010]., [RefSeq]; Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Use of non-AUG (AUA) translation initiation site and alternate downstream start sites, results in multiple SP3 isoforms., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 15,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 15,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 15,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 35,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 16,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AVL9;B4E2B7;Q69B26;Q69B27;Q8TD56;Q8WWU4;Q9BQR1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0016605 PML body;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 13.0,
        "record_id": "Q02447-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q16877-1",
        "uniprot_id": "F264_HUMAN",
        "mass": 54040.0,
        "length": 469,
        "protein_name": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4",
        "gene_name": "PFKFB4",
        "organism": "Human",
        "refseq_name": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform a",
        "refseq_ac": "NP_001304063",
        "gene_names_uniprotkb": "PFKFB4",
        "gene_names_refseq": "PFKFB4",
        "protein_names_uniprotkb": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4; 6PF-2-K/Fru-2,6-P2ase 4; 6PF-2-K/Fru-2,6-P2ase testis-type isozyme; PFK/FBPase 4",
        "protein_names_refseq": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform a; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4; 6PF-2-K/Fru-2,6-P2ase 4; 6PF-2-K/Fru-2,6-P2ase testis-type isozyme; PFK/FBPase 4; bifunctional enzyme with kinase and biphosphatase activities",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5210);  (R-HSA-9634600)",
        "pathway_count": 2,
        "publication_count": 70,
        "publication_id_list": "10095107;11237011;12721358;15474002;15642344;15896703;16959974;22544926;23481700;24714562;24715725;25576301;25645385;26154972;26375851;27920218;28228285;2837207;28832583;28855257;28860189;29242379;29493099;29557506;29632711;3052289;30524438;31154438;31217245;31530632;31844290;31998317;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33717175;33912179;33968037;33981976;34087483;34171305;34211107;34405274;34509645;34561969;35051231;35494241;35561310;35580925;35705054;36010968;36109523;36284347;36581221;37500615;37707291;39097875;39097893;39182558;7574501;8830046;9464277",
        "class_list": "",
        "function": "Expression and prognostic analysis of PFKFB4 in oral squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Fibrillarin reprograms glucose metabolism by driving the enhancer-mediated transcription of PFKFB4 in liver cancer., [RefSeq, PubMed]; MiR-3195 inhibits non-small cell lung cancer malignant behaviors along with cisplatin resistance through targeting PFKFB4. Publication Status: Online-Only, [RefSeq, PubMed]; Synthesis and degradation of fructose 2,6-bisphosphate., [UniProtKB, UniProtKB]; THOC3 interacts with YBX1 to promote lung squamous cell carcinoma progression through PFKFB4 mRNA modification. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]., [RefSeq]; Transforming growth factor beta1 upregulates 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-4 expression in A549 and MCF-10A cells., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5S3G5;Q5XLC2;Q64EX5",
        "ec_number_list": "2.7.1.105;3.1.3.46",
        "go_molecular_function": "GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524 ATP binding;GO:0003873 6-phosphofructo-2-kinase activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0006094 gluconeogenesis;GO:0006000 fructose metabolic process;GO:0006096 glycolytic process;GO:0006003 fructose 2,6-bisphosphate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.3,
        "record_id": "Q16877-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14534-1",
        "uniprot_id": "ERG1_HUMAN",
        "mass": 63923.0,
        "length": 574,
        "protein_name": "Squalene monooxygenase",
        "gene_name": "SQLE",
        "organism": "Human",
        "refseq_name": "squalene monooxygenase",
        "refseq_ac": "NP_003120",
        "gene_names_uniprotkb": "SQLE; ERG1",
        "gene_names_refseq": "SQLE",
        "protein_names_uniprotkb": "Squalene monooxygenase; 1.14.14.17; SE; Squalene epoxidase",
        "protein_names_refseq": "SE; squalene monooxygenase",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:6713);  (R-HSA-2426168);  (R-HSA-9969896)",
        "pathway_count": 3,
        "publication_count": 149,
        "publication_id_list": "10026212;10400691;10620343;10666321;10759542;10896663;11160603;11237011;11414710;12083769;12177166;12764144;1377680;14729858;14730012;14766201;16464866;16519518;16684881;17449569;17925399;18327899;18559965;18654640;18682402;18726356;18937434;18991276;1968462;20138239;20394422;20450493;20719759;20937905;21420384;22634312;22645359;23481700;24366607;24449766;24714562;24715725;25576301;25645385;25892735;26154972;26375851;26434806;26728094;26992070;27600516;27846572;27893789;27920218;28063628;28218747;28228285;28514659;28649982;28832583;28834231;28855257;28904123;28972164;29242379;29331515;29393594;29437277;29493099;29557506;29632046;29765154;29769354;30315122;30410026;30524438;30626872;30779550;31154438;31217245;31530632;31844290;31848261;31998317;32157095;32161166;32265295;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33246356;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34357683;34405274;34509645;34561969;34932366;35051231;35318648;35561310;35580925;36010968;36241641;36284347;36581221;37938771;38084535;38280406;38372422;38517197;38612682;5918048;7567999;7592729;7732023;7909540;7911016;7913309;8020941;8593458;8619637;8626466;8626488;8647822;8663599;8798690;8806705;8976377;9099716;9286711;9380443;9604010;9634533;9741684;9748295",
        "class_list": "",
        "function": "Age-related cholesterol and colorectal cancer progression: Validating squalene epoxidase for high-risk cases., [RefSeq, PubMed]; Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Functional promotor regions involved in transcription was determined, [RefSeq, PubMed]; Identifying squalene epoxidase as a metabolic vulnerability in high-risk osteosarcoma using an artificial intelligence-derived prognostic index., [RefSeq, PubMed]; Squalene Epoxidase: Its Regulations and Links with Cancers. Publication Status: Online-Only, [RefSeq, PubMed]; Squalene monooxygenase facilitates bladder cancer development in part by regulating PCNA., [RefSeq, PubMed]; The expression of squalene epoxidase in human gastric cancer and its clinical significance., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UEK6;Q9UNR6",
        "ec_number_list": "1.14.14.17",
        "go_molecular_function": "GO:0071949 FAD binding;GO:0004506 squalene monooxygenase activity;GO:0050660 flavin adenine dinucleotide binding",
        "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0043231 intracellular membrane-bounded organelle;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0016126 sterol biosynthetic process;GO:0006695 cholesterol biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol;GO:0033490 cholesterol biosynthetic process via lathosterol",
        "synthesized_glycan_count": 0,
        "hit_score": 15.0,
        "record_id": "Q14534-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P42566-1",
        "uniprot_id": "EPS15_HUMAN",
        "mass": 98656.0,
        "length": 896,
        "protein_name": "Epidermal growth factor receptor substrate 15",
        "gene_name": "EPS15",
        "organism": "Human",
        "refseq_name": "epidermal growth factor receptor substrate 15 isoform B",
        "refseq_ac": "NP_001153441",
        "gene_names_uniprotkb": "EPS15; AF1P",
        "gene_names_refseq": "AF-1P; AF1P; EPS15; MLLT5",
        "protein_names_uniprotkb": "Epidermal growth factor receptor substrate 15; Protein AF-1p; Protein Eps15",
        "protein_names_refseq": "ALL1 fused gene from chromosome 1; epidermal growth factor receptor substrate 15 isoform B; epidermal growth factor receptor substrate 15; protein AF-1p",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); Lewy body dementia (Disease Ontology:DOID:12217); Parkinson's disease (Disease Ontology:DOID:14330); ovarian cancer (Disease Ontology:DOID:2394); demyelinating disease (Disease Ontology:DOID:3213); breast carcinoma (Disease Ontology:DOID:3459); renal cell carcinoma (Disease Ontology:DOID:4450); multiple system atrophy (Disease Ontology:DOID:4752)",
        "pathway": " (hsa:2060);  (R-HSA-182971);  (R-HSA-6807004);  (R-HSA-8856825);  (R-HSA-8856828);  (R-HSA-8875360);  (R-HSA-9766229)",
        "pathway_count": 7,
        "publication_count": 362,
        "publication_id_list": "10097102;10393179;10436022;10514377;10535736;10542231;10559856;10559861;10559924;10567358;10613896;10625686;10652316;10757979;10766823;10769163;10953014;10983987;11062555;11071885;11076969;11081636;11082044;11231140;11237011;11239472;11247302;11454741;11470803;11516654;11517213;11532990;11577110;11588219;11741535;11823423;11877457;11877461;11889126;11894095;11894096;11919637;11927540;11988742;12057195;12072436;12086608;12213833;12218189;12221107;12234920;12234931;12244174;12429842;12447393;12451172;12464600;12475979;12551915;12593795;12593796;12686592;12717448;12847086;12944396;12952949;12958364;1317852;14505571;14517306;14555962;14581451;14617351;14622578;14622579;14662753;14726597;14985334;15021893;15117950;15123609;15134832;15252009;15260957;15318165;15339664;1535555;15465819;15473838;15475003;15502812;15502813;15649145;15671180;15701692;15703209;15728179;15802264;15828871;15895077;15916959;15962011;16103228;16113677;16159959;16215232;16227611;16314522;16325581;16326391;16407834;16410077;16459302;16460808;16516836;16707488;16723738;16798879;16880396;16903783;16964243;17016520;17018281;17035995;17158794;17178829;17267500;17322306;17360967;17389395;17456551;17494869;17512409;17522231;17525332;17540576;17609109;17662939;17681954;17713526;17762867;17765681;17978091;18032517;18088087;18093523;18166656;18199683;18200045;18362181;18388313;1847920;18669648;18691976;18767875;18775314;18790740;18819912;18819921;18981233;19054389;19092055;19109251;19140243;19287005;19296720;19413330;19458185;19536138;19575674;19603039;19651622;19664994;19664995;1968060;19690332;19696796;19696798;19713939;19732400;19776351;19809571;19814798;19853559;19900460;20033059;20058876;20059951;20068231;20166139;20211604;20231386;20351096;20428113;20448150;20826345;20946875;21102408;2115402;21187331;21278753;21316588;21376233;21406692;21445324;21482805;21499258;21613550;21762413;21779028;21841790;21883765;21927000;21927001;21962517;21995445;22099461;22118466;22223895;22233676;22357968;22484487;22505844;22544926;2257624;22648170;22815487;22863004;22869377;22942912;23186163;23208509;23297414;23301498;23481700;23536704;23823722;23861397;23891661;24130457;24186068;24269888;24275569;24366607;24384571;24581490;24680432;24714562;24715725;24746795;24768539;24789820;24828152;24966051;25107275;25253721;25263444;25303366;25341920;25576301;25645385;26042225;26154972;26280083;26375851;26403691;26728094;26822536;26829388;26992070;27397612;27670116;27846572;27920218;28218747;28228285;28832583;28834231;2890644;29242379;29356040;29393594;29437277;29493099;29508533;29557506;29632711;29786170;30315122;30429286;30779550;31154438;31217245;31222486;31530632;31844290;31848261;31998317;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32938616;32938750;32983136;33037466;33091337;33298915;33592498;33717175;33912179;33936100;33968037;34087483;3417785;34357683;34433824;34509645;34932366;35051231;35154160;35254053;35318648;35580925;36010968;36215666;36241641;36284347;37217939;37827695;37938771;40307207;40914422;6146630;7541030;7542744;7569928;7657591;7822302;7877694;8134107;8183552;8524399;8552632;8553074;8621719;8662907;8837779;9092476;9100026;9169477;9303539;9427626;9428629;9635431;9721102;9723620;9736607;9812899",
        "class_list": "",
        "function": "EPS15-NTRK1: a novel NTRK1 oncogenic fusion in patient with lung adenocarcinoma., [RefSeq, PubMed]; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Modified iPOND revealed the role of mutant p53 in promoting helicase function and telomere maintenance., [RefSeq, PubMed]; This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 21,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 9,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R8J7;D3DPJ2;Q5SRH4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0030674 protein-macromolecule adaptor activity;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit",
        "go_biological_process": "GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:0006897 endocytosis;GO:0042127 regulation of cell population proliferation;GO:0016197 endosomal transport;GO:0046718 symbiont entry into host cell",
        "synthesized_glycan_count": 0,
        "hit_score": 36.6,
        "record_id": "P42566-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95677-1",
        "uniprot_id": "EYA4_HUMAN",
        "mass": 69505.0,
        "length": 639,
        "protein_name": "Protein phosphatase EYA4",
        "gene_name": "EYA4",
        "organism": "Human",
        "refseq_name": "protein phosphatase EYA4 isoform e",
        "refseq_ac": "NP_001287941",
        "gene_names_uniprotkb": "EYA4",
        "gene_names_refseq": "CMD1J; DFNA10; EYA4",
        "protein_names_uniprotkb": "Protein phosphatase EYA4; 3.1.3.48; Eyes absent homolog 4",
        "protein_names_refseq": "dJ78N10.1 (eyes absent); eyes absent homolog 4; eyes absent-like protein 4; protein phosphatase EYA4 isoform e; protein phosphatase EYA4",
        "tax_id": 9606,
        "disease": "dilated cardiomyopathy 1J (Disease Ontology:DOID:0110440); autosomal dominant nonsyndromic deafness 10 (Disease Ontology:DOID:0110542); sensorineural hearing loss (Disease Ontology:DOID:10003); otitis media (Disease Ontology:DOID:10754); dilated cardiomyopathy (Disease Ontology:DOID:12930); branchiootorenal syndrome (Disease Ontology:DOID:14702); eye disease (Disease Ontology:DOID:5614); congestive heart failure (Disease Ontology:DOID:6000)",
        "pathway": " (hsa:2070);  (R-HSA-5693565)",
        "pathway_count": 2,
        "publication_count": 112,
        "publication_id_list": "10550055;10724175;10766245;10802669;10866324;10959836;10973490;11025670;11114888;11159937;11237011;11390408;11571274;11573085;11893489;11927591;11934988;12364621;12447390;12485996;12607003;12607005;12697768;12773400;12792649;12832489;12890688;14560035;15064416;15201865;15279782;15735644;16150728;16377563;16427009;16651405;16959974;16964243;17525332;17525340;17553757;17848578;18001824;18001825;18006705;18077395;18443292;18644861;18669648;18691976;19001859;19092802;19117993;19176521;19203578;19203579;19234442;19261749;19351884;19606496;19651622;19782031;20016603;20023648;20068231;20351172;21282113;21293379;22234877;22373579;22508508;22589545;22908299;22938506;22980979;23186163;23301498;24667604;25809937;25961296;26992070;28834231;29242379;30379171;30484775;30620550;30833945;31154438;31217245;31844290;32157095;32897882;32983136;33592498;33859130;33968037;34019948;34087483;34171305;35051231;35138101;35254053;35578334;36010968;36453428;37541260;37777742;38665916;8944023;9168116;9488723;9887327",
        "class_list": "",
        "function": "Aberrant DNA methylation and expression of EYA4 in gastric cardia intestinal metaplasia., [RefSeq, PubMed]; EYA4 promotes breast cancer progression and metastasis through its role in replication stress avoidance. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of a Novel Copy Number Variation of EYA4 Causing Autosomal Dominant Non-syndromic Hearing Loss., [RefSeq, PubMed]; Identification of a novel CNV at the EYA4 gene in a Chinese family with autosomal dominant nonsyndromic hearing loss. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]., [RefSeq]; Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity)., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 45,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z7F7;O95464;O95679;Q8IW39;Q9NTR7",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.21;3.1.3.18;3.1.3.-;3.1.3.5;3.1.3.2;2.7.10.1;3.1.-.-;3.1.3.67;2.7.11.1;3.1.3.27;3.6.-.-;2.3.1.48;2.3.1.-",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0004725 protein tyrosine phosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0007601 visual perception;GO:0045739 positive regulation of DNA repair",
        "synthesized_glycan_count": 0,
        "hit_score": 12.1,
        "record_id": "O95677-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95208-1",
        "uniprot_id": "EPN2_HUMAN",
        "mass": 68482.0,
        "length": 641,
        "protein_name": "Epsin-2",
        "gene_name": "EPN2",
        "organism": "Human",
        "refseq_name": "epsin-2 isoform c",
        "refseq_ac": "NP_001096134",
        "gene_names_uniprotkb": "EPN2; KIAA1065",
        "gene_names_refseq": "EHB21; EPN2",
        "protein_names_uniprotkb": "Epsin-2; EPS-15-interacting protein 2",
        "protein_names_refseq": "EPS-15-interacting protein 2; Eps15 binding protein; epsin-2 isoform c",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:22905);  (R-HSA-8856825);  (R-HSA-8856828)",
        "pathway_count": 3,
        "publication_count": 243,
        "publication_id_list": "10097102;10436022;10535736;10542231;10559856;10559861;10559924;10567358;10613896;10625686;10766823;10769163;10983987;11071885;11076969;11082044;11231140;11237011;11239472;11247302;11454741;11470803;11516654;11517213;11532990;11577110;11588219;11877457;11877461;11889126;11919637;11927540;11988742;12057195;12086608;12213833;12221107;12234931;12429842;12447393;12451172;12464600;12717448;12847086;12944396;12952949;12958364;1317852;14555962;14581451;14617351;14622578;14622579;14662753;14726597;15134832;15252009;15260957;15318165;15339664;15345747;1535555;15473838;15502812;15502813;15649145;15671180;15703209;15728179;15802264;15895077;15916959;16103228;16159959;16215232;16326391;16410077;16459302;16460808;16516836;16707488;16723738;16798879;16880396;16903783;17018281;17035995;17081983;17158794;17267500;17360967;17456551;17494869;17512409;17522231;17540576;17609109;17681954;17713526;17762867;17765681;17978091;18032517;18093523;18166656;18199683;18388313;18452278;1847920;18775314;18790740;18819912;18981233;19092055;19140243;19287005;19296720;19413330;19458185;19536138;19575674;19603039;1968060;19696796;19696798;19713939;19732400;19776351;19809571;19853559;20033059;20059951;20068231;20211604;20231386;20351096;20428113;20448150;20826345;20946875;21102408;2115402;21187331;21278753;21316588;21406692;21445324;21482805;21499258;21613550;21779028;21841790;21883765;21927000;21927001;21962517;21995445;22099461;22118466;22233676;22357968;22484487;22505844;2257624;22815487;22863004;22942912;23186163;23297414;23481700;23536704;23823722;23861397;23891661;24130457;24186068;24275569;24384571;24581490;24680432;24715725;24746795;24789820;24966051;25107275;25303366;25341920;25576301;25645385;25871009;26042225;26154972;26403691;26829388;27846572;27862975;28717225;28834231;2890644;29393594;29508533;29557506;29632711;29786170;29789417;30459171;31154438;31844290;31848261;31998317;32157095;32350084;32502341;33968037;33981976;34019948;3417785;35051231;35251023;35318648;35580925;36241641;36284347;38253038;40596516;6146630;7569928;7822302;7877694;8524399;8552632;8553074;8837779;9092476;9100026;9169477;9303539;9427626;9428629;9635431;9723620;9736607;9812899",
        "class_list": "",
        "function": "EPN2 mRNA is a direct target of miR-1224. Publication Status: Online-Only, [RefSeq, PubMed]; Epsins are required for Dishevelled stability and Wnt signalling activation in colon cancer development. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the formation of clathrin-coated invaginations and endocytosis., [UniProtKB, PubMed]; This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MTV8;B3KRX8;E9PBC2;O95207;Q52LD0;Q9H7Z2;Q9UPT7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005543 phospholipid binding;GO:0045296 cadherin binding;GO:0030276 clathrin binding;GO:0008289 lipid binding",
        "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006897 endocytosis;GO:0045747 positive regulation of Notch signaling pathway;GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:1903671 negative regulation of sprouting angiogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 24.8,
        "record_id": "O95208-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NQX3-1",
        "uniprot_id": "GEPH_HUMAN",
        "mass": 79748.0,
        "length": 736,
        "protein_name": "Gephyrin",
        "gene_name": "GPHN",
        "organism": "Human",
        "refseq_name": "gephyrin isoform 2",
        "refseq_ac": "NP_001019389",
        "gene_names_uniprotkb": "GPHN; GPH; KIAA1385",
        "gene_names_refseq": "GEPH; GPHN; GPHRYN; GPH; HKPX1; MOCODC",
        "protein_names_uniprotkb": "Gephyrin; Domain E; Domain G; Mo insertase",
        "protein_names_refseq": "gephyrin isoform 2",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); molybdenum cofactor deficiency type C (Disease Ontology:DOID:0111166); inherited metabolic disorder (Disease Ontology:DOID:655)",
        "pathway": " (hsa:10243);  (R-HSA-947581)",
        "pathway_count": 2,
        "publication_count": 88,
        "publication_id_list": "10839351;11095995;11237011;11302742;11418245;11554796;12571226;12684523;12732628;16964243;17081983;17322306;18491316;18510355;18650437;18669648;19413330;19651622;19690332;20068231;20166139;21173228;21406692;22040219;22270318;22778260;23408424;23481700;24165455;24275569;24715725;25025157;25093719;25576301;25645385;26154972;26375851;26613940;27600516;27846572;27920218;28228285;28514659;28657654;28832583;29242379;29314611;29331515;29493099;29508533;29557506;30192525;30315122;30573663;30779550;30833945;31154438;31373491;31844290;31848261;31998317;32119511;32157095;32161166;32350084;32357974;32488085;32502341;32938616;33141586;33298915;33592498;33796945;33968037;34171305;34357683;34932366;35051231;35154160;35254053;35580925;35717442;36010968;36215666;36284347;38665916;40307207;9990024",
        "class_list": "",
        "function": "Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released., [UniProtKB, UniProtKB, UniProtKB]; Complex regulation of Gephyrin splicing is a determinant of inhibitory postsynaptic diversity. Publication Status: Online-Only, [RefSeq, PubMed]; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 21,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96KU4;Q9H4E9;Q9P2G2",
        "ec_number_list": "2.10.1.1;2.7.7.75",
        "go_molecular_function": "GO:0008940 nitrate reductase activity;GO:0061598 molybdopterin adenylyltransferase activity;GO:0061599 molybdopterin molybdotransferase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding",
        "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0072579 glycine receptor clustering;GO:0097112 gamma-aminobutyric acid receptor clustering;GO:0007529 establishment of synaptic specificity at neuromuscular junction;GO:0007416 synapse assembly;GO:0045184 establishment of protein localization",
        "synthesized_glycan_count": 0,
        "hit_score": 9.4,
        "record_id": "Q9NQX3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UDV6-1",
        "uniprot_id": "ZN212_HUMAN",
        "mass": 55447.0,
        "length": 495,
        "protein_name": "Zinc finger protein 212",
        "gene_name": "ZNF212",
        "organism": "Human",
        "refseq_name": "zinc finger protein 212",
        "refseq_ac": "NP_036388",
        "gene_names_uniprotkb": "ZNF212; ZNFC150",
        "gene_names_refseq": "C2H2-150; ZNF182; ZNF212; ZNFC150",
        "protein_names_uniprotkb": "Zinc finger protein 212; Zinc finger protein C2H2-150",
        "protein_names_refseq": "Zinc finger protein C2H2-150; zinc finger protein 212",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7988);  (R-HSA-212436)",
        "pathway_count": 2,
        "publication_count": 27,
        "publication_id_list": "10235266;10330177;11237011;11395415;14519192;15175151;15896744;16606702;16719718;2163759;27600516;28832583;29493099;29632046;31844290;32387766;32938616;33592498;33968037;34171305;36594163;7633419;8183939;8769649;9169157;9637681;9653119",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB]; This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions. [provided by RefSeq, Jul 2008]., [RefSeq]; ZNF212 promotes genomic integrity through direct interaction with TRAIP., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCF4;Q13396;Q8N664",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051402 neuron apoptotic process;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q9UDV6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92889-1",
        "uniprot_id": "XPF_HUMAN",
        "mass": 104486.0,
        "length": 916,
        "protein_name": "DNA repair endonuclease XPF",
        "gene_name": "ERCC4",
        "organism": "Human",
        "refseq_name": "DNA repair endonuclease XPF",
        "refseq_ac": "NP_005227",
        "gene_names_uniprotkb": "ERCC4; ERCC11; XPF",
        "gene_names_refseq": "ERCC11; ERCC4; FANCQ; RAD1; XFEPS; XPF",
        "protein_names_uniprotkb": "DNA repair endonuclease XPF; 3.1.-.-; DNA excision repair protein ERCC-4; DNA repair protein complementing XP-F cells; Xeroderma pigmentosum group F-complementing protein",
        "protein_names_refseq": "DNA excision repair protein ERCC-4; DNA repair endonuclease XPF; DNA repair protein complementing XP-F cells; excision repair cross-complementation group 4; excision repair cross-complementing rodent repair deficiency, complementation group 4; excision-repair, complementing defective, in Chinese hamster; xeroderma pigmentosum group F-complementing protein; xeroderma pigmentosum, complementation group F",
        "tax_id": 9606,
        "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); XFE progeroid syndrome (Disease Ontology:DOID:0060590); xeroderma pigmentosum group A (Disease Ontology:DOID:0110843); xeroderma pigmentosum group F (Disease Ontology:DOID:0110848); Fanconi anemia complementation group Q (Disease Ontology:DOID:0111093); Fanconi anemia (Disease Ontology:DOID:13636); polyneuropathy due to drug (Disease Ontology:DOID:14184); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); Cockayne syndrome (Disease Ontology:DOID:2962); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:2072);  (R-HSA-5685938);  (R-HSA-5696395);  (R-HSA-5696400);  (R-HSA-6782135);  (R-HSA-6783310)",
        "pathway_count": 6,
        "publication_count": 191,
        "publication_id_list": "10212258;10413517;10438626;10447254;10479728;10526214;10734143;10744977;10921897;11007478;11141066;11237011;11239454;11278856;11511374;11571269;11698410;11790111;12080057;12139939;12191481;12226092;12370410;12379650;12750383;14517266;14652281;14734547;15220921;15485900;15572677;15590680;16030353;16076955;16246722;16338413;16491090;16916645;16943440;17000769;17081983;17183314;17289582;17412408;17460694;17466625;17466626;17682675;17938197;17948053;17962301;18079701;18082604;18174376;18539610;18541667;18614043;18701435;18757400;18931676;19056823;19111657;19279666;19561358;19589784;19595721;19595722;19596235;19596236;19608861;19661379;19713942;19940136;19941824;19995904;20102227;20227374;20347428;20347429;20368362;20385554;20603015;20603016;20603073;20670894;20671156;20876134;20965415;21282463;21424776;21464321;21701511;21764741;21804533;22081108;22258451;22287633;22396592;22510687;22692201;22706990;23038248;23045548;23325218;23352696;23481700;23619551;23623386;23623389;23698467;23723247;23751493;24027083;24076221;24366607;24389026;24402227;24623813;24726325;24905007;25023197;25154395;25418920;25430771;25500724;25538220;25576301;26042670;26146099;26151477;26154972;26375851;26811146;26992070;27600516;27846572;27862975;27920218;28228285;28514659;28832583;28855257;28904123;29242379;29331515;29393594;29557506;30315122;30410026;30429286;31217245;31844290;32034146;32157095;32357974;32387766;32897882;32938616;33141586;33298915;33392160;33592498;33717175;33912179;33968037;34087483;34171305;34509645;34633654;34837148;35051231;35580925;35780063;36070459;37217939;37938771;7559382;7700386;8078911;8692841;8702565;8797827;8887684;9130708;9485007;9579555;9580660;9699634;9716411;9771713;9837724",
        "class_list": "",
        "function": "Association of ERCC1 and XPF polymorphisms with pediatric glioma susceptibility. Publication Status: Online-Only, [RefSeq, PubMed]; Association of nonsynonymous SNPs of nucleotide excision repair genes ERCC4 rs1800067 (G/A) and ERCC5 rs17655 (G/C) as predisposing risk factors for gallbladder cancer., [RefSeq, PubMed]; Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; F-circEA1 regulates cell proliferation and apoptosis through ALK downstream signaling pathway in non-small cell lung cancer., [RefSeq, PubMed]; The link of ERCC2 rs13181 and ERCC4 rs2276466 polymorphisms with breast cancer in the Bangladeshi population., [RefSeq, PubMed]; The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 11,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5PKV6;A8K111;O00140;Q8TD83",
        "ec_number_list": "3.6.4.13;3.4.19.12;2.4.2.-;2.4.2.30;5.6.2.3;6.5.1.1;5.6.2.4;3.1.13.-;2.7.7.48;2.7.7.6;2.7.7.7;3.1.11.-;3.1.-.-;2.3.2.27;2.7.11.22;2.7.11.23;2.7.11.24;2.3.2.32;3.6.4.-;2.7.11.1;5.6.2.1;3.5.2.6;3.6.-.-;2.3.1.48;2.3.1.-;3.1.22.-;3.1.11.2;5.2.1.8;3.1.21.-;3.1.4.1",
        "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0003684 damaged DNA binding;GO:0004520 DNA endonuclease activity;GO:0001094 TFIID-class transcription factor complex binding",
        "go_cellular_component": "GO:0000110 nucleotide-excision repair factor 1 complex;GO:0070522 ERCC4-ERCC1 complex;GO:0000109 nucleotide-excision repair complex;GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0032205 negative regulation of telomere maintenance;GO:0061819 telomeric DNA-containing double minutes formation;GO:1905765 negative regulation of protection from non-homologous end joining at telomere;GO:0006281 DNA repair",
        "synthesized_glycan_count": 0,
        "hit_score": 19.4,
        "record_id": "Q92889-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P35637-1",
        "uniprot_id": "FUS_HUMAN",
        "mass": 53426.0,
        "length": 526,
        "protein_name": "RNA-binding protein FUS",
        "gene_name": "FUS",
        "organism": "Human",
        "refseq_name": "RNA-binding protein FUS isoform 2",
        "refseq_ac": "NP_001164105",
        "gene_names_uniprotkb": "FUS; TLS",
        "gene_names_refseq": "ALS6; ETM4; FUS1; FUS; HNRNPP2; POMP75; TLS; altFUS",
        "protein_names_uniprotkb": "RNA-binding protein FUS; 75 kDa DNA-pairing protein; Oncogene FUS; Oncogene TLS; POMp75; Translocated in liposarcoma protein",
        "protein_names_refseq": "75 kDa DNA-pairing protein; RNA-binding protein FUS isoform 2; RNA-binding protein FUS; fus-like protein; fused in sarcoma; fusion gene in myxoid liposarcoma; heterogeneous nuclear ribonucleoprotein P2; oncogene FUS; oncogene TLS; translocated in liposarcoma protein",
        "tax_id": 9606,
        "disease": "amyotrophic lateral sclerosis type 6 (Disease Ontology:DOID:0060198); essential tremor 4 (Disease Ontology:DOID:0111431); sarcoma (Disease Ontology:DOID:1115); neurodegenerative disease (Disease Ontology:DOID:1289); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); liposarcoma (Disease Ontology:DOID:3382); frontotemporal dementia (Disease Ontology:DOID:9255); histiocytoma, Angiomatoid fibrous (MONDO:MONDO:0012809)",
        "pathway": " (hsa:2521);  (R-HSA-72163);  (R-HSA-72203);  (R-HSA-9770562);  (R-HSA-9918481)",
        "pathway_count": 5,
        "publication_count": 241,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10442642;10567410;10669729;10882114;11014198;11060040;11063792;11101529;11233976;11237011;11747608;11991638;12176931;12411573;12414731;12477934;12964758;14519844;14625303;14713954;14749727;14762106;15037765;15084397;15565158;16314458;16809785;16959974;17095540;17128255;17196963;17332742;17606899;18288197;18322460;18452278;18593880;18620545;18632687;19103666;19165350;19217410;19251627;19251628;19536130;19651622;19690332;19861302;20068231;20124201;20423332;20579074;20695905;20980672;21256132;21295486;21406692;21536652;21740066;2176635;21911577;22110043;22365833;22813749;22863194;22959432;22961380;23186163;23222130;23236153;23345524;23555621;23584533;23874216;24076191;24129315;24149845;24196718;24204307;24304693;24316715;24407421;24448447;24715725;24737827;24914973;24981863;25301780;25301781;25453086;25555158;2558966;25810538;25880248;26092250;26124092;26154972;26385511;26403203;26420826;26969736;26992070;27108190;27377154;27459055;27543614;27600516;27604643;27615052;27683217;27731383;27846572;27920218;28062851;28076346;28096519;28121444;28502770;28514659;28649982;28781166;28790177;28832583;28904123;28911096;29186539;29242379;29274231;29301961;29331515;29351928;29360106;29361316;29393594;29493099;29508533;29557506;2963332;29769354;29786170;29789417;29897835;29902443;29930882;30139799;30192525;30257008;30315122;30315277;30354839;30397120;30429286;30599162;30705154;30728453;30765414;30975767;31154438;31217245;31409651;31844290;32119511;32157095;32179686;32329775;32357974;32387766;32488085;32494006;32502341;32816001;32897882;32938616;32983136;33091337;33141586;33177556;33214551;33243851;33392160;33446560;33592498;33691108;33912179;33968037;33981976;34019948;34087483;34171305;34229054;34301950;34509645;34725712;34822310;34932366;35008409;35051231;35138101;35154160;35177536;35215846;35318648;35385551;35561310;35580925;36215666;36241641;36284347;36581221;36963488;37217939;3757028;37938771;38593618;38632300;38665916;38671504;38862967;39456230;40596516;7503811;8187069;8352591;8510758;8566756;8608946;9016565;9242493;9409616;9512519;9524131;9539711;9659921;9660765;9671485;9701291;9731529;9774382;9795213",
        "class_list": "",
        "function": "A dynamic regulatory switch for phase separation of FUS protein: Zinc ions and zinc finger domain., [RefSeq, PubMed]; An aberrant fused in sarcoma liquid droplet of amyotrophic lateral sclerosis pathological variant, R495X, accelerates liquid-solid phase transition. Publication Status: Online-Only, [RefSeq, PubMed]; DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair. In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Deciphering the role of FUS::DDIT3 expression and tumor microenvironment in myxoid liposarcoma development. Publication Status: Online-Only, [RefSeq, PubMed]; FUS::DDIT3 Fusion Protein in the Development of Myxoid Liposarcoma and Possible Implications for Therapy. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 12,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 12,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 12,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 21,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 8,
        "glyco_site_count": 13,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9H4A8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0099523 presynaptic cytosol",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0048255 mRNA stabilization;GO:0051260 protein homooligomerization;GO:1990000 amyloid fibril formation;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 25.9,
        "record_id": "P35637-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BWW4-1",
        "uniprot_id": "SSBP3_HUMAN",
        "mass": 40421.0,
        "length": 388,
        "protein_name": "Single-stranded DNA-binding protein 3",
        "gene_name": "SSBP3",
        "organism": "Human",
        "refseq_name": "single-stranded DNA-binding protein 3 isoform c",
        "refseq_ac": "NP_001009955",
        "gene_names_uniprotkb": "SSBP3; SSDP1; SSDP",
        "gene_names_refseq": "CSDP; SSBP3; SSDP1; SSDP",
        "protein_names_uniprotkb": "Single-stranded DNA-binding protein 3; Sequence-specific single-stranded-DNA-binding protein",
        "protein_names_refseq": "sequence-specific single-stranded-DNA-binding protein; single-stranded DNA-binding protein 3 isoform c",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)",
        "pathway": " (hsa:23648)",
        "pathway_count": 1,
        "publication_count": 58,
        "publication_id_list": "11237011;12079286;12381786;16325762;17322306;18080319;18220336;18669648;19413330;19651622;19664994;19664995;19690332;20068231;21406692;22028470;23186163;24129315;24275569;24715725;29351928;29437277;29485866;29493099;29557506;31844290;32157095;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33691108;33717175;33912179;33936100;33968037;34087483;34211107;34357683;34405274;34509645;34932366;35051231;35254053;35561310;35580925;36010968;36284347;37536498;37541260;37938771;38665916;40307207;40596516",
        "class_list": "",
        "function": "May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region., [UniProtKB]; Phosphorylation involving N-terminal tyrosine residues of Ssdp1 is a means of regulating its nuclear localization and subsequent transcriptional activation of LIM-HD complexes., [RefSeq, PubMed]; Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development, [RefSeq, PubMed]; The SSBP3 co-regulator is required for glucose homeostasis, pancreatic islet architecture, and beta-cell identity., [RefSeq, PubMed]; Thus, biochemical data of SSDP1 presented by this study provides biochemical evidence for a better understanding of transcriptional regulation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K0A9;Q5T860;Q5T861;Q9BTM0;Q9BWW3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003697 single-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex",
        "go_biological_process": "GO:0060323 head morphogenesis;GO:0021501 prechordal plate formation;GO:0021547 midbrain-hindbrain boundary initiation;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "Q9BWW4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y256-1",
        "uniprot_id": "FACE2_HUMAN",
        "mass": 35833.0,
        "length": 329,
        "protein_name": "CAAX prenyl protease 2",
        "gene_name": "RCE1",
        "organism": "Human",
        "refseq_name": "CAAX prenyl protease 2 isoform 2",
        "refseq_ac": "NP_001027450",
        "gene_names_uniprotkb": "RCE1; FACE2; RCE1A; RCE1B",
        "gene_names_refseq": "FACE2; RCE1A; RCE1B; RCE1",
        "protein_names_uniprotkb": "CAAX prenyl protease 2; 3.4.26.1; FACE-2; Farnesylated proteins-converting enzyme 2; Prenyl protein-specific endoprotease 2; RCE1 homolog; hRCE1",
        "protein_names_refseq": "CAAX prenyl protease 2 isoform 2; CAAX prenyl protease 2; RCE1 homolog, prenyl protein peptidase; farnesylated protein-converting enzyme 2; farnesylated proteins-converting enzyme 2; prenyl protein-specific endoprotease 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9986);  (R-HSA-5689880);  (R-HSA-9648002)",
        "pathway_count": 3,
        "publication_count": 165,
        "publication_id_list": "10085068;10085069;10373325;10444327;10667208;10982817;11038283;11120601;11196150;11237011;11566882;11585916;11739732;11923872;12433685;12727204;12750467;12818187;12917689;12917691;14504265;14561760;14660603;14661020;14966563;15053880;15451670;15659645;15916963;16000296;16043511;16214042;16483930;16901786;16959974;16964248;17290220;17443180;17873522;17980597;17981138;18172164;18182391;18467330;18502828;18632802;18636086;19015242;19135894;19188362;19363159;19398555;19424180;19838211;19874889;19910467;20096447;20228808;20368735;20416930;20418879;20501646;20622895;20802526;21170358;21239494;21362556;21571647;21596315;21659512;21661760;21779505;21849505;21905185;21905186;21962518;22002721;22029577;22085928;22128162;22144181;22179043;22195972;22216260;22589270;22721555;23159851;23395819;23486064;23514631;23698361;23824326;23825189;23943869;24033119;24056413;24134311;24260525;24493797;24715725;24725411;24896179;24971579;25197364;25305019;25550383;25578727;25713064;25759176;25781681;25892735;26085527;26546252;26590425;2661017;26701913;26706195;26771141;2682646;26992070;27094677;27396271;27410739;27697864;27791178;27920218;28159979;28167504;28615075;28630138;28666118;28778966;28832583;28834231;28904123;29242379;29311131;29424242;30315122;31092671;31506952;31844290;32157095;32161166;32387766;32877642;32897882;32938616;32983136;33298915;33537174;33691108;34171305;34185709;34509645;34932366;35051231;35580925;36010968;36284347;7578059;9436858;9810004;9822558;9851253",
        "class_list": "",
        "function": "A novel RCE1 isoform is required for H-Ras plasma membrane localization regulated by ubiquitin specific peptidase (USP)17., [RefSeq, PubMed]; CAAX endoprotease Rce1 is required for lamin B1 endoproteolysis, [RefSeq, PubMed]; High expression of Rce1 is associated with renal cell carcinoma., [RefSeq, PubMed]; Protease involved in the processing of a variety of prenylated proteins containing the C-terminal CAAX motif, where C is a cysteine modified with an isoprenoid lipid, A is an aliphatic amino acid and X is any C-terminal amino acid. Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins, leaving the prenylated cysteine as the new C-terminus. Is able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068)., [UniProtKB, PubMed, PubMed, PubMed]; RCE1 acts as a tumor suppressor in CRC, as its reduced expression may increase CRC cell invasion and independently predict an unsatisfactory prognosis in CRC patients. Publication Status: Online-Only, [RefSeq, PubMed]; Rce1 suppresses invasion and metastasis of hepatocellular carcinoma via epithelial-mesenchymal transition induced by the TGF-beta1/H-Ras signaling pathway. Erratum:[J Cell Physiol. 2026 Jan;241(1):e70132. doi: 10.1002/jcp.70132. PMID: 41566797], [RefSeq, PubMed]; Suggests that expression of Rce1 can serve as an independent biomarker for the prognosis of prostate carcinoma patients., [RefSeq, PubMed]; This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family.  This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins. [provided by RefSeq, Jul 2008]., [RefSeq]; We found that an 8-aa K-Ras-derived 'CAA' peptide, KSKTKC(farnesyl)VI, was a better substrate for hRCE1 than a KSKTKC(f)VIM 'CAAX' peptide, hRCE1 has important interaction with the P2' and P3' substrate positions in addition to the farnesylated cysteine, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q52LZ9",
        "ec_number_list": "3.4.19.12;3.6.4.13;3.6.5.2;3.1.3.48;3.4.26.1",
        "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008238 exopeptidase activity;GO:0004197 cysteine-type endopeptidase activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0071586 CAAX-box protein processing;GO:0000165 MAPK cascade;GO:0018342 protein prenylation",
        "synthesized_glycan_count": 0,
        "hit_score": 16.6,
        "record_id": "Q9Y256-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P61019-1",
        "uniprot_id": "RAB2A_HUMAN",
        "mass": 23546.0,
        "length": 212,
        "protein_name": "Ras-related protein Rab-2A",
        "gene_name": "RAB2A",
        "organism": "Human",
        "refseq_name": "ras-related protein Rab-2A isoform b",
        "refseq_ac": "NP_001229573",
        "gene_names_uniprotkb": "RAB2A; RAB2",
        "gene_names_refseq": "LHX; RAB2A; RAB2",
        "protein_names_uniprotkb": "Ras-related protein Rab-2A; 3.6.5.2",
        "protein_names_refseq": "RAB2, member RAS oncogene family; ras-related protein Rab-2A isoform b; ras-related protein Rab-2A; small GTP binding protein RAB2A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5862);  (R-HSA-162658);  (R-HSA-8873719)",
        "pathway_count": 3,
        "publication_count": 101,
        "publication_id_list": "10.1101/2023.09.13.557529;10679020;11141079;11237011;11238451;11285137;11306556;11389151;11408587;11447212;11447294;11675392;11739401;12695496;12839990;14570876;15678101;16034420;16401880;1648736;16533948;17081065;17114793;17182854;17411337;18167358;18385516;18434598;18532927;18578522;1902553;19603039;19651986;20068231;20083603;20214750;20937827;22694141;22726585;24023390;2501306;25341920;25367160;25473115;25502872;26209634;26969162;26992070;28483915;29242379;29493099;29557506;29774024;30573663;3057444;30833945;31020640;31217245;31844290;31848261;32157095;32350084;32488085;32938616;32983136;33043033;33592498;33717175;33912179;33968037;34019948;34078123;34171305;34433824;34932366;35051231;35154160;35251023;35343109;35561310;35580925;36215666;36284347;37217939;37821429;37932299;38665916;40307207;40596516;7737117;7957092;7991565;8164745;8349690;8375503;8513495;8631982;8662963;8836150;9150144;9753325",
        "class_list": "",
        "function": "Integration of risk variants from GWAS with SARS-CoV-2 RNA interactome prioritizes FUBP1 and RAB2A as risk genes for COVID-19. Publication Status: Online-Only, [RefSeq, PubMed]; RAB2A promotes cervical cancer progression as revealed by comprehensive analysis of HPV integration and proteome in longitudinal cervical samples., [RefSeq, PubMed]; The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]., [RefSeq]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (PubMed:37821429). RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion (PubMed:37821429). Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with RAB2B, redundantly required for efficient autophagic flux (PubMed:28483915)., [UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5W8;B4DMQ5;P08886",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;2.7.11.24;3.6.1.-;2.7.11.21;2.5.1.60;3.6.5.4;2.7.11.1;3.6.-.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005829 cytosol",
        "go_biological_process": "GO:0015031 protein transport;GO:0016236 macroautophagy;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0016192 vesicle-mediated transport;GO:0007030 Golgi organization",
        "synthesized_glycan_count": 0,
        "hit_score": 10.7,
        "record_id": "P61019-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q0VG06-1",
        "uniprot_id": "FP100_HUMAN",
        "mass": 93433.0,
        "length": 881,
        "protein_name": "Fanconi anemia core complex-associated protein 100",
        "gene_name": "FAAP100",
        "organism": "Human",
        "refseq_name": "Fanconi anemia core complex-associated protein 100 isoform b",
        "refseq_ac": "NP_079437",
        "gene_names_uniprotkb": "FAAP100; C17orf70",
        "gene_names_refseq": "C17orf70; FAAP100; FANCX",
        "protein_names_uniprotkb": "Fanconi anemia core complex-associated protein 100; Fanconi anemia-associated protein of 100 kDa",
        "protein_names_refseq": "Fanconi anemia associated protein 100 kDa subunit; Fanconi anemia core complex 100 kDa subunit; Fanconi anemia core complex associated protein 100; Fanconi anemia core complex-associated protein 100 isoform b; Fanconi anemia-associated protein, 100kDa; fanconi anemia-associated protein of 100 kDa",
        "tax_id": 9606,
        "disease": "fanconi anemia, complementation group 10 (MONDO:MONDO:0979241)",
        "pathway": " (hsa:80233);  (R-HSA-6783310);  (R-HSA-9833482)",
        "pathway_count": 3,
        "publication_count": 205,
        "publication_id_list": "10082513;10348343;10400669;10620360;10626894;10648614;10848580;10866685;11096080;11134010;11152499;11156368;11237011;11238103;11238927;11239454;11278865;11313968;11337501;11350938;11438540;11500375;11781817;11909525;11939789;11985496;12231563;12397061;12882984;1373135;14585331;15229216;15299030;15572677;15737233;15752359;15907845;16179258;16179259;16373505;16431927;16600570;16717090;16916645;16943440;1695551;16982605;17079286;17196820;17289582;17396147;17412408;17460694;17938197;18082604;18096616;18174376;18669648;18835251;18931676;18957415;19111657;19229320;19416861;19561358;19589784;19596236;19710021;19733181;19804757;19838063;19995904;20102227;20347428;20347429;20385554;20395957;20519500;20603015;20603016;20603073;20670894;20671156;20685959;21072047;21123651;21294215;21464321;21518807;21636578;21701511;21764741;21937648;21978664;21994559;22214662;22258451;22287633;22396592;2247437;22510687;22692201;22986343;23084476;23186163;23229543;23325218;23481700;23698467;23723247;23732991;24076221;24275569;24347309;24389026;24623135;24623813;24659800;24715725;24726325;24753571;24905007;25430771;25500724;25505266;25653431;25848059;26432638;26446704;26488609;26716879;26817845;27208315;27269119;27423063;27846572;27974558;28069888;28167698;28281686;28765891;28904123;29170442;29175459;29231267;29348664;29394925;29395325;29440070;29501855;30174290;30379171;30770398;31031002;31217245;31844290;31848261;32093270;32157095;32387766;32502341;32716602;32801355;32897882;32938616;33141586;33298915;33808629;33911136;33968037;34087483;34174402;34509645;34974812;35051231;35580925;35685460;35947956;36240223;36241641;36712380;37127961;40232843;40244696;7491766;7515177;7545299;7565688;7693978;7737357;7903669;8576172;8576179;8661426;8810342;8910500;9034343;9079663;9442054;9521856;9528799;9687506;9737981;9819388;9920933",
        "class_list": "",
        "function": "FAAP100 as a new critical component of the FA-BRCA DNA damage response network., [RefSeq, PubMed]; FAAP100 is a component of the Fanconi anemia (FA; MIM 277650) core complex and is required for core complex stability and FANCD2 (see MIM 227646) monoubiquitination (Ling et al., 2007 [PubMed 17396147]).[supplied by OMIM, Mar 2008]., [RefSeq]; Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NNM1;Q8N3F7;Q9BV13;Q9H6K7;Q9H7E8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding",
        "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin",
        "go_biological_process": "GO:0036297 interstrand cross-link repair",
        "synthesized_glycan_count": 0,
        "hit_score": 20.8,
        "record_id": "Q0VG06-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q17RC7-1",
        "uniprot_id": "EX3L4_HUMAN",
        "mass": 79896.0,
        "length": 722,
        "protein_name": "Exocyst complex component 3-like protein 4",
        "gene_name": "EXOC3L4",
        "organism": "Human",
        "refseq_name": "exocyst complex component 3-like protein 4",
        "refseq_ac": "NP_001071062",
        "gene_names_uniprotkb": "EXOC3L4; C14orf73",
        "gene_names_refseq": "C14orf73; EXOC3L4",
        "protein_names_uniprotkb": "Exocyst complex component 3-like protein 4",
        "protein_names_refseq": "SEC6-like protein C14orf73; exocyst complex component 3-like protein 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91828)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11237011;23186163;24275569;29351928;29557506;30255815;30379171;31844290;32387766;32938616;33141586;33592498;35051231",
        "class_list": "",
        "function": "Rare variants in the splicing regulatory elements of EXOC3L4 are associated with Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14CR2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000149 SNARE binding",
        "go_cellular_component": "GO:0000145 exocyst",
        "go_biological_process": "GO:0051601 exocyst localization;GO:0006887 exocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q17RC7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96MC2-1",
        "uniprot_id": "DRC1_HUMAN",
        "mass": 87134.0,
        "length": 740,
        "protein_name": "Dynein regulatory complex protein 1",
        "gene_name": "DRC1",
        "organism": "Human",
        "refseq_name": "dynein regulatory complex protein 1",
        "refseq_ac": "NP_659475",
        "gene_names_uniprotkb": "DRC1; C2orf39; CCDC164",
        "gene_names_refseq": "C2orf39; CCDC164; CILD21; DRC1; SPGF80",
        "protein_names_uniprotkb": "Dynein regulatory complex protein 1; Coiled-coil domain-containing protein 164",
        "protein_names_refseq": "coiled-coil domain-containing protein 164; dynein regulatory complex protein 1",
        "tax_id": 9606,
        "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); spermatogenic failure 80 (Disease Ontology:DOID:0070579); primary ciliary dyskinesia 21 (Disease Ontology:DOID:0110596)",
        "pathway": " (hsa:92749)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;23354437;24715725;25186273;29237092;31960620;32502341;34169321;34815526;35051231;35580925;35873463;36747106;36864285",
        "class_list": "",
        "function": "Characteristic genetic spectrum of primary ciliary dyskinesia in Japanese patients and global ethnic heterogeneity: population-based genomic variation database analysis., [RefSeq, PubMed]; Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes (PubMed:23354437, PubMed:34169321). Coassembles with DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:23354437)., [UniProtKB, PubMed, UniProtKB, PubMed]; Copy number variation in DRC1 is the major cause of primary ciliary dyskinesia in the Japanese population., [RefSeq, PubMed]; Loss of DRC1 function leads to multiple morphological abnormalities of the sperm flagella and male infertility in human and mouse., [RefSeq, PubMed]; Loss-of-function mutations disrupting DRC1 result in severe defects in assembly of the N-DRC structure and defective ciliary movement in Chlamydomonas reinhardtii and humans, [RefSeq, PubMed]; Prevalence and founder effect of DRC1 exon 1-4 deletion in Korean patients with primary ciliary dyskinesia., [RefSeq, PubMed]; This gene encodes a central component of the nexin-dynein complex (N-DRC), which regulates the assembly of ciliary dynein. Mutations in this gene can cause ciliary dyskinesia. [provided by RefSeq, Aug 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K1N8;Q53R91;Q53TA3;Q8NDI5",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0005858 axonemal dynein complex",
        "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0003341 cilium movement;GO:0060285 cilium-dependent cell motility;GO:0070286 axonemal dynein complex assembly;GO:0003352 regulation of cilium movement",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q96MC2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96C19-1",
        "uniprot_id": "EFHD2_HUMAN",
        "mass": 26697.0,
        "length": 240,
        "protein_name": "EF-hand domain-containing protein D2",
        "gene_name": "EFHD2",
        "organism": "Human",
        "refseq_name": "EF-hand domain-containing protein D2",
        "refseq_ac": "NP_077305",
        "gene_names_uniprotkb": "EFHD2; SWS1",
        "gene_names_refseq": "EFHD2; SWS1",
        "protein_names_uniprotkb": "EF-hand domain-containing protein D2; Swiprosin-1",
        "protein_names_refseq": "EF hand domain containing 2; EF-hand domain-containing protein D2; swiprosin 1; testicular tissue protein Li 62",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79180);  (R-HSA-9013405)",
        "pathway_count": 2,
        "publication_count": 94,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11784792;11788997;12577064;15274114;16964243;17064668;17081983;17287340;17322306;17916560;17924679;18212344;18669648;18691976;18767875;19118655;19165527;19413330;19415658;19608861;19664994;19690332;20058876;20068231;21993680;22665057;23087206;23096567;23186163;23301498;23481700;24102721;24275569;25418920;25505266;25548167;25576301;25746724;26375851;26768311;26811146;26992070;27481945;27852748;27862975;28011271;28486133;28649982;28832583;28904123;28947137;29242379;29331515;29393594;29493099;29508533;29557506;29632046;29776664;30429286;30833945;31217245;31665741;31844290;31871319;31998317;32157095;32265295;32350084;32446175;32488085;32502341;32567430;32938616;32983136;33043033;33123756;33592498;33717175;33968037;34171305;34357683;34509645;35051231;35276221;35580925;36010968;36284347;38665916;39302247;39990658;8945468",
        "class_list": "",
        "function": "Association between EFHD2 gene polymorphisms and schizophrenia among the Han population in northern China., [RefSeq, PubMed]; EFHD2 contributes to non-small cell lung cancer cisplatin resistance by the activation of NOX4-ROS-ABCC1 axis., [RefSeq, PubMed]; Its predominant presence in CD8 lymphocytes suggests that swiprosin-1 may be involved in functions that are important for cytotoxic lymphocytes., [RefSeq, PubMed]; May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance., [UniProtKB]; Our study uncovers a protein complex, which consists of SWS1, SWSAP1, SPIDR and PDS5B, involved in DNA repair and provides insight into Shu complex function and composition, [RefSeq, PubMed]; Role of Swiprosin-1/EFHD2 as a biomarker in the development of chronic diseases. Review article, [RefSeq, PubMed]; Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5JYW9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0051015 actin filament binding;GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0061891 calcium ion sensor activity",
        "go_cellular_component": "GO:0030027 lamellipodium;GO:0045121 membrane raft",
        "go_biological_process": "GO:0051764 actin crosslink formation",
        "synthesized_glycan_count": 0,
        "hit_score": 9.9,
        "record_id": "Q96C19-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q99848-1",
        "uniprot_id": "EBP2_HUMAN",
        "mass": 34852.0,
        "length": 306,
        "protein_name": "Probable rRNA-processing protein EBP2",
        "gene_name": "EBNA1BP2",
        "organism": "Human",
        "refseq_name": "probable rRNA-processing protein EBP2 isoform 1",
        "refseq_ac": "NP_001153408",
        "gene_names_uniprotkb": "EBNA1BP2; EBP2",
        "gene_names_refseq": "EBNA1BP2; EBP2; NOBP; P40",
        "protein_names_uniprotkb": "Probable rRNA-processing protein EBP2; EBNA1-binding protein 2; Nucleolar protein p40",
        "protein_names_refseq": "homolog of yeast EBNA1-binding protein; nuclear FGF3 binding protein; nucleolar protein p40; probable rRNA-processing protein EBP2 isoform 1; probable rRNA-processing protein EBP2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10969);  (R-HSA-6791226)",
        "pathway_count": 2,
        "publication_count": 103,
        "publication_id_list": "10074103;11237011;11327720;11922599;12068309;12150911;16037817;16043514;16738141;17081983;17189298;17353269;17412707;18065403;18438418;18452278;18669648;19106111;19170763;19332556;19564402;19651622;19691289;19801658;20038530;20056613;20068231;20531386;20798176;20805244;20819938;21036871;21063389;21097556;22072790;22121020;22190735;22195017;22916032;23186163;23439679;23482395;23848194;2388630;24424021;24550520;24715725;25525153;25576301;25969445;26237581;26992070;27920218;28228285;28411811;2879624;28832583;28834231;29242379;29393594;29632046;30224479;30315122;30379171;30410026;30444036;30484775;30524438;31154438;31222486;31530632;31844290;31848261;32157095;32350084;32387766;32488085;32502341;32938616;33040459;33141586;33214551;33592498;33691108;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34229054;34405274;34509645;34561969;35051231;35251023;35318648;35580925;36241641;37217939;38665916;9482744",
        "class_list": "",
        "function": "EBP2, a novel NPM-ALK-interacting protein in the nucleolus, contributes to the proliferation of ALCL cells by regulating tumor suppressor p53., [RefSeq, PubMed]; Required for the processing of the 27S pre-rRNA., [UniProtKB, UniProtKB, UniProtKB]; Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96A66",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0005694 chromosome;GO:0034399 nuclear periphery",
        "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0006364 rRNA processing;GO:0042254 ribosome biogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 10.6,
        "record_id": "Q99848-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96PT4-1",
        "uniprot_id": "DUX3_HUMAN",
        "mass": 22130.0,
        "length": 197,
        "protein_name": "Putative double homeobox protein 3",
        "gene_name": "DUX3",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DUX3",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative double homeobox protein 3",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283)",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "11245978",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UND2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "Q96PT4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q99956-1",
        "uniprot_id": "DUS9_HUMAN",
        "mass": 41868.0,
        "length": 384,
        "protein_name": "Dual specificity protein phosphatase 9",
        "gene_name": "DUSP9",
        "organism": "Human",
        "refseq_name": "dual specificity protein phosphatase 9",
        "refseq_ac": "NP_001305432",
        "gene_names_uniprotkb": "DUSP9; MKP4",
        "gene_names_refseq": "DUSP9; MKP-4; MKP4",
        "protein_names_uniprotkb": "Dual specificity protein phosphatase 9; 3.1.3.16; 3.1.3.48; MAP kinase phosphatase 4; MKP-4; Mitogen-activated protein kinase phosphatase 4",
        "protein_names_refseq": "dual specificity protein phosphatase 9; map kinase phosphatase 4; mitogen-activated protein kinase phosphatase 4; serine/threonine specific protein phosphatase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:1852);  (R-HSA-112409);  (R-HSA-5675221);  (R-HSA-9652817)",
        "pathway_count": 4,
        "publication_count": 49,
        "publication_id_list": "10206983;10415025;10490027;10702794;10757792;12583813;14724641;15664191;15851477;16892053;17097642;17208316;17724343;18006813;18058037;18294816;18332145;18515281;18547165;18669648;19091743;19158341;20068231;20112406;20332238;20463170;21206059;21779496;21908610;22569528;22730326;23105109;23186163;24390348;25314968;25597358;25631445;26992070;27760319;29557506;32157095;32387766;33968037;34171305;34509645;34768967;35051231;36980809;9030581",
        "class_list": "",
        "function": "2.7 A resolution crystal structure of the catalytic domain of MKP-4 (MKP-4C) is presented, [RefSeq, PubMed]; DUSP9, a Dual-Specificity Phosphatase with a Key Role in Cell Biology and Human Diseases. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Genetic Variants of HNF4A, WFS1, DUSP9, FTO, and ZFAND6 Genes Are Associated with Prediabetes Susceptibility and Inflammatory Markers in the Saudi Arabian Population. Publication Status: Online-Only, [RefSeq, PubMed]; Inactivates MAP kinases. Has a specificity for the ERK family., [UniProtKB]; Microtubule disruption by MKP4 provides a novel mechanism for tumor suppression by a cytosolic MKP, [RefSeq, PubMed]; The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DWU5",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.21;3.1.3.18;3.1.3.-;3.1.3.5;3.1.3.2;2.7.11.24;2.7.10.1;3.1.3.67;3.1.3.53;3.1.3.52;3.1.3.27;3.1.3.86;3.1.3.36;3.1.3.74",
        "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0000165 MAPK cascade;GO:0007254 JNK cascade;GO:0070371 ERK1 and ERK2 cascade;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0006470 protein dephosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "Q99956-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BU89-1",
        "uniprot_id": "DOHH_HUMAN",
        "mass": 32904.0,
        "length": 302,
        "protein_name": "Deoxyhypusine hydroxylase",
        "gene_name": "DOHH",
        "organism": "Human",
        "refseq_name": "deoxyhypusine hydroxylase",
        "refseq_ac": "NP_001138637",
        "gene_names_uniprotkb": "DOHH; HLRC1",
        "gene_names_refseq": "DOHH; HLRC1; NEDMVIC; hDOHH",
        "protein_names_uniprotkb": "Deoxyhypusine hydroxylase; 1.14.99.29; Deoxyhypusine dioxygenase; Deoxyhypusine monooxygenase; HEAT-like repeat-containing protein 1; hDOHH",
        "protein_names_refseq": "HEAT-like (PBS lyase) repeat containing 1; HEAT-like repeat-containing protein 1; deoxyhypusine dioxygenase; deoxyhypusine hydroxylase/monooxygenase; deoxyhypusine hydroxylase; deoxyhypusine monooxygenase",
        "tax_id": 9606,
        "disease": "pulmonary hypertension (Disease Ontology:DOID:6432); neurodevelopmental disorder with microcephaly, cerebral atrophy, and visual impairment (MONDO:MONDO:0859293)",
        "pathway": " (hsa:83475);  (R-HSA-204626)",
        "pathway_count": 2,
        "publication_count": 52,
        "publication_id_list": "11237011;12788913;14622290;16371467;16452303;16533814;17213197;19706422;22223895;23301498;23481700;25418920;25576301;25865244;25880248;26375851;26992070;27920218;28228285;28514659;28649982;28832583;28834231;28904123;29242379;29393594;30429286;31844290;31848261;32157095;32488085;32502341;32897882;32938616;32983136;33592498;33912179;33936100;33968037;33981976;34087483;34171305;35007708;35051231;35561310;35580925;35858628;36010968;37141410;40136647;7673224;9188485",
        "class_list": "",
        "function": "Analysis of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction, [RefSeq, PubMed]; Bi-allelic variants in DOHH, catalyzing the last step of hypusine biosynthesis, are associated with a neurodevelopmental disorder., [RefSeq, PubMed]; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine (PubMed:16371467, PubMed:16533814, PubMed:19706422). Hypusination is unique to mature eIF-5A factor and is essential for its function (By similarity)., [UniProtKB, PubMed, PubMed, HAMAP, PubMed, UniProtKB, UniProtKB, UniProtKB]; Data describes 3-D structure of hDOHH in two states, hDOHHperoxo (POX) and a complex of the diiron core with glycerol (GLC) providing an explanation for the extreme longevity of POX and illustrate its substrate specificity for deoxyhypusine-eIF-5A., [RefSeq, PubMed]; Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification., [RefSeq, PubMed]; Deoxyhypusine hydroxylase: A novel therapeutic target differentially expressed in short-term vs long-term survivors of glioblastoma., [RefSeq, PubMed]; The structure and function of DOHH are reported. Erratum:[J Biol Chem. 2007 Apr 6;282(14):10840], [RefSeq, PubMed]; This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75265",
        "ec_number_list": "1.14.99.29",
        "go_molecular_function": "GO:0019135 deoxyhypusine monooxygenase activity;GO:0005506 iron ion binding",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0008612 peptidyl-lysine modification to peptidyl-hypusine",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "Q9BU89-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BUY7-1",
        "uniprot_id": "EFC11_HUMAN",
        "mass": 19225.0,
        "length": 163,
        "protein_name": "EF-hand calcium-binding domain-containing protein 11",
        "gene_name": "EFCAB11",
        "organism": "Human",
        "refseq_name": "EF-hand calcium-binding domain-containing protein 11 isoform 2",
        "refseq_ac": "NP_001271195",
        "gene_names_uniprotkb": "EFCAB11; C14orf143",
        "gene_names_refseq": "C14orf143; EFCAB11",
        "protein_names_uniprotkb": "EF-hand calcium-binding domain-containing protein 11",
        "protein_names_refseq": "EF-hand calcium-binding domain-containing protein 11 isoform 2; EF-hand calcium-binding domain-containing protein 11; EF-hand domain-containing protein C14orf143",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:90141)",
        "pathway_count": 1,
        "publication_count": 31,
        "publication_id_list": "11237011;25576301;25645385;25665738;25892735;26992070;27846572;27920218;28218747;29242379;29331515;29437277;29557506;29769354;29789417;30315122;30779550;31154438;31844290;32157095;32161166;32357974;33298915;33717175;33912179;33968037;33981976;34171305;35580925;36010968;37938771",
        "class_list": "",
        "function": "This work reported the association of 14q32.11 (EFCAB11) with Hepatocellular carcinoma in Chinese Han population and revealed the genetic interaction between STAT4 (2q32.2-q32.3) and EFCAB11 (14q32.11) in Hepatocellular carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KT10;B7Z5G9;G3V5G1;Q86T09;Q86TV7;Q8NDQ1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030234 enzyme regulator activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0000226 microtubule cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q9BUY7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NR50-1",
        "uniprot_id": "EI2BG_HUMAN",
        "mass": 50240.0,
        "length": 452,
        "protein_name": "Translation initiation factor eIF2B subunit gamma",
        "gene_name": "EIF2B3",
        "organism": "Human",
        "refseq_name": "translation initiation factor eIF2B subunit gamma isoform 2",
        "refseq_ac": "NP_001160060",
        "gene_names_uniprotkb": "EIF2B3",
        "gene_names_refseq": "EIF-2B; EIF2B3; EIF2Bgamma; VWM3",
        "protein_names_uniprotkb": "Translation initiation factor eIF2B subunit gamma; eIF2B GDP-GTP exchange factor subunit gamma",
        "protein_names_refseq": "eIF-2B GDP-GTP exchange factor subunit gamma; eIF2B GDP-GTP exchange factor subunit gamma; eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa; translation initiation factor eIF-2B subunit gamma; translation initiation factor eIF2B subunit gamma isoform 2; translation initiation factor eIF2B subunit gamma",
        "tax_id": 9606,
        "disease": "leukoencephalopathy with vanishing white matter (Disease Ontology:DOID:0060868); leukoencephalopathy with vanishing white matter 3 (Disease Ontology:DOID:0070372)",
        "pathway": " (hsa:8891);  (R-HSA-72731)",
        "pathway_count": 2,
        "publication_count": 52,
        "publication_id_list": "10900014;11237011;11835386;19158808;21484434;22223895;23186163;23301498;23481700;2491852;25576301;25858979;25892735;26992070;27023709;27600516;28228285;28510447;28832583;28834231;28904123;29242379;29393594;29786170;30315122;30429286;31048492;31530632;31844290;32157095;32350084;32357974;32502341;32938616;33141586;33298915;33517449;3356695;33592498;33717175;33912179;33968037;34171305;34357683;34725712;34932366;35051231;35251023;36010968;37938771;39531497;40914422",
        "class_list": "",
        "function": "Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Eif2b3 mutants recapitulate phenotypes of vanishing white matter disease and validate novel disease alleles in zebrafish., [RefSeq, PubMed]; The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RBH8;D3DPZ2;Q5QP89;Q5QP90;Q8NDB5;Q8WV57;Q9H850",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003743 translation initiation factor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005851 eukaryotic translation initiation factor 2B complex",
        "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0050852 T cell receptor signaling pathway;GO:0006413 translational initiation;GO:0009749 response to glucose;GO:0043434 response to peptide hormone",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "Q9NR50-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A1L162-1",
        "uniprot_id": "ERIC2_HUMAN",
        "mass": 17672.0,
        "length": 156,
        "protein_name": "Glutamate-rich protein 2",
        "gene_name": "ERICH2",
        "organism": "Human",
        "refseq_name": "glutamate-rich protein 2 isoform 2",
        "refseq_ac": "NP_001276876",
        "gene_names_uniprotkb": "ERICH2",
        "gene_names_refseq": "ERICH2",
        "protein_names_uniprotkb": "Glutamate-rich protein 2",
        "protein_names_refseq": "glutamate-rich protein 2 isoform 2; glutamate-rich protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:285141)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "11237011;29557506;34087483;39894887",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7E2T7",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "A1L162-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A6NHQ4-1",
        "uniprot_id": "EPOP_HUMAN",
        "mass": 39322.0,
        "length": 379,
        "protein_name": "Elongin BC and Polycomb repressive complex 2-associated protein",
        "gene_name": "EPOP",
        "organism": "Human",
        "refseq_name": "elongin BC and Polycomb repressive complex 2-associated protein",
        "refseq_ac": "NP_001124149",
        "gene_names_uniprotkb": "EPOP; C17orf96; PRR28",
        "gene_names_refseq": "C17orf96; EPOP; PRR28",
        "protein_names_uniprotkb": "Elongin BC and Polycomb repressive complex 2-associated protein; Proline-rich protein 28",
        "protein_names_refseq": "elongin BC and Polycomb repressive complex 2-associated protein; proline rich 28; proline-rich protein 28; uncharacterized protein C17orf96",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100170841);  (R-HSA-212300)",
        "pathway_count": 2,
        "publication_count": 30,
        "publication_id_list": "12351676;12435631;15099518;16357870;16431907;18669648;18974356;19026781;19571010;20075857;20123894;20937877;20974918;21170310;22323599;22466170;23326524;23431328;23679895;24074865;24129315;24550272;29499137;30779550;30923826;31086175;33298915;33912179;35051231;37217939",
        "class_list": "",
        "function": "Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0044877 protein-containing complex binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005694 chromosome;GO:0035098 ESC/E(Z) complex;GO:0070449 elongin complex",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0048863 stem cell differentiation;GO:0048663 neuron fate commitment;GO:0031507 heterochromatin formation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "A6NHQ4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A8MTA8-1",
        "uniprot_id": "CMI2B_HUMAN",
        "mass": 30575.0,
        "length": 275,
        "protein_name": "Ciliary microtubule inner protein 2B",
        "gene_name": "CIMIP2B",
        "organism": "Human",
        "refseq_name": "ciliary microtubule inner protein 2B isoform 2",
        "refseq_ac": "NP_001093421",
        "gene_names_uniprotkb": "CIMIP2B; FAM166B",
        "gene_names_refseq": "CIMIP2B; FAM166B",
        "protein_names_uniprotkb": "Ciliary microtubule inner protein 2B",
        "protein_names_refseq": "ciliary microtubule inner protein 2B isoform 2; family with sequence similarity 166 member B; protein FAM166B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:730112)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "11237011;35051231;35580925;36191189;39894887",
        "class_list": "",
        "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L3B2;B7ZBJ0",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005879 axonemal microtubule",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "A8MTA8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A8MX19-1",
        "uniprot_id": "F90AC_HUMAN",
        "mass": 49786.0,
        "length": 464,
        "protein_name": "Protein FAM90A12",
        "gene_name": "FAM90A12",
        "organism": "Human",
        "refseq_name": "protein FAM90A12",
        "refseq_ac": "NP_001410460",
        "gene_names_uniprotkb": "FAM90A12; FAM90A12P",
        "gene_names_refseq": "FAM90A12P; FAM90A12",
        "protein_names_uniprotkb": "Protein FAM90A12; Protein FAM90A12P",
        "protein_names_refseq": "Putative protein FAM90A12; family with sequence similarity 90 member A12, pseudogene; protein FAM90A12; putative protein FAM90A12P",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:645879)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "17684299;22299025",
        "class_list": "",
        "function": "FAM90A12 belongs to subfamily II of the primate-specific FAM90A gene family, which originated from multiple duplications and rearrangements (Bosch et al., 2007 [PubMed 17684299]). For background information on the FAM90A gene family, as well as information on the evolution of FAM90A genes, see FAM90A1 (MIM 613041).[supplied by OMIM, Jul 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "A8MX19-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A8MXJ8-1",
        "uniprot_id": "F90A5_HUMAN",
        "mass": 49840.0,
        "length": 464,
        "protein_name": "Protein FAM90A5",
        "gene_name": "FAM90A5",
        "organism": "Human",
        "refseq_name": "protein FAM90A5",
        "refseq_ac": "NP_001410458",
        "gene_names_uniprotkb": "FAM90A5; FAM90A5P",
        "gene_names_refseq": "FAM90A5P; FAM90A5",
        "protein_names_uniprotkb": "Protein FAM90A5",
        "protein_names_refseq": "family with sequence similarity 90 member A5, pseudogene; protein FAM90A5; putative protein FAM90A5P; putative protein FAM90A5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:441315)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "17684299",
        "class_list": "",
        "function": "FAM90A5 belongs to subfamily II of the primate-specific FAM90A gene family, which originated from multiple duplications and rearrangements (Bosch et al., 2007 [PubMed 17684299]). For background information on the FAM90A gene family, as well as information on the evolution of FAM90A genes, see FAM90A1 (MIM 613041).[supplied by OMIM, May 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "A8MXJ8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "B6SEH8-1",
        "uniprot_id": "ERVV1_HUMAN",
        "mass": 52557.0,
        "length": 477,
        "protein_name": "Endogenous retrovirus group V member 1 Env polyprotein",
        "gene_name": "ERVV-1",
        "organism": "Human",
        "refseq_name": "endogenous retrovirus group V member 1 Env polyprotein precursor",
        "refseq_ac": "NP_689686",
        "gene_names_uniprotkb": "ERVV-1; ENVV1",
        "gene_names_refseq": "ENVV1; ERVV-1; HERV-V1",
        "protein_names_uniprotkb": "Endogenous retrovirus group V member 1 Env polyprotein; HERV-V_19q13.41 provirus ancestral Env polyprotein 1",
        "protein_names_refseq": "HERV-V_19q13.41 provirus ancestral Env polyprotein 1; endogenous retrovirus group V member 1 Env polyprotein precursor; endogenous retrovirus group V member 1 Env polyprotein; endogenous retrovirus group V, member 1; endogenous retrovirus group V, member 2; envelope glycoprotein ENVV1; envelope protein ENVV1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:147664)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "18826608;23555306;31092671;31844290;32161166;32387766;33392160;35051231;37217939;38253038",
        "class_list": "",
        "function": "In the Old World monkeys, we show that envV is both specifically expressed at the level of the placental syncytiotrophoblast and fusogenic., [RefSeq, PubMed]; Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on human chromosome 19 that has inactivating mutations in the gag and pol genes. The gene's envelope protein is expressed in the human placenta but is truncated at its C-terminus. [provided by RefSeq, Oct 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "B6SEH8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "B6SEH9-1",
        "uniprot_id": "ERVV2_HUMAN",
        "mass": 59317.0,
        "length": 535,
        "protein_name": "Endogenous retrovirus group V member 2 Env polyprotein",
        "gene_name": "ERVV-2",
        "organism": "Human",
        "refseq_name": "endogenous retrovirus group V member 2 Env polyprotein precursor",
        "refseq_ac": "NP_001177984",
        "gene_names_uniprotkb": "ERVV-2; ENVV2",
        "gene_names_refseq": "ENVV2; ERVV-2; HERV-V2",
        "protein_names_uniprotkb": "Endogenous retrovirus group V member 2 Env polyprotein; HERV-V_19q13.41 provirus ancestral Env polyprotein 2",
        "protein_names_refseq": "HERV-V_19q13.41 provirus ancestral Env polyprotein 2; endogenous retrovirus HSV2; endogenous retrovirus group V member 2 Env polyprotein precursor; endogenous retrovirus group V member 2 Env polyprotein; endogenous retrovirus group V, member 2; envelope glycoprotein ENVV2; envelope protein ENVV2; mac-syncytin-3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100271846)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "18826608;26758079;28228285;30315122;33968037;35051231",
        "class_list": "",
        "function": "Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on human chromosome 19 that has inactivating mutations in the gag and pol genes. This envelope glycoprotein gene appears to have been selectively preserved. The gene's protein product is expressed in the placenta and acts as a syncytin in Old World monkeys, but has lost the fusogenic activity in humans and other primate lineages. [provided by RefSeq, Jun 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "B6SEH9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NYQ8-1",
        "uniprot_id": "FAT2_HUMAN",
        "mass": 479317.0,
        "length": 4349,
        "protein_name": "Protocadherin Fat 2",
        "gene_name": "FAT2",
        "organism": "Human",
        "refseq_name": "protocadherin Fat 2 precursor",
        "refseq_ac": "NP_001438",
        "gene_names_uniprotkb": "FAT2; CDHF8; KIAA0811; MEGF1",
        "gene_names_refseq": "CDHF8; CDHR9; FAT2; HFAT2; MEGF1; SCA45",
        "protein_names_uniprotkb": "Protocadherin Fat 2; Cadherin family member 8; Multiple EGF-like domains protein 1; Multiple epidermal growth factor-like domains protein 1; hFat2",
        "protein_names_refseq": "FAT tumor suppressor homolog 2; cadherin family member 8; cadherin-related family member 9; multiple EGF like domains 1; multiple EGF-like domains protein 1; multiple epidermal growth factor-like domains 1; multiple epidermal growth factor-like domains protein 1; protocadherin FAT2; protocadherin Fat 2 precursor",
        "tax_id": 9606,
        "disease": "spinocerebellar ataxia 45 (Disease Ontology:DOID:0080287); Diamond-Blackfan anemia 13 (Disease Ontology:DOID:0111889)",
        "pathway": " (hsa:2196)",
        "pathway_count": 1,
        "publication_count": 41,
        "publication_id_list": "10.1038/emboj.2013.79;10716726;11237011;16335952;16865240;17900869;18534823;20068231;23090970;23481700;23584533;24190977;25576301;25645385;27081041;27600516;28411811;28832583;29053796;29557506;29786170;30429286;31092671;31222486;31398327;31844290;32157095;32161166;32387766;32488085;32502341;33108146;33392160;33592498;34185709;34308747;35051231;35389803;35580925;36010968;9693030",
        "class_list": "",
        "function": "DeltaNp63alpha (TP63) is co-expressed with FAT2 and Slug in patient tumors and the elevated expression of DeltaNp63alpha, FAT2 and Slug correlated with poor patient outcome., [RefSeq, PubMed]; Identification of the RP11-21C4.1/SVEP1 gene pair associated with FAT2 mutations as a potential biomarker in gastric cancer., [RefSeq, PubMed]; Involved in the regulation of cell migration (PubMed:18534823). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity)., [UniProtKB, PubMed, UniProtKB]; Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 27,
        "predicted_n_glycosites": 24,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 14,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 14,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 14,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 285,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 43,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75091;Q9NSR7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0010631 epithelial cell migration;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0031589 cell-substrate adhesion;GO:0044331 cell-cell adhesion mediated by cadherin",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "Q9NYQ8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZRV2-1",
        "uniprot_id": "FA83H_HUMAN",
        "mass": 127122.0,
        "length": 1179,
        "protein_name": "Protein FAM83H",
        "gene_name": "FAM83H",
        "organism": "Human",
        "refseq_name": "protein FAM83H",
        "refseq_ac": "NP_940890",
        "gene_names_uniprotkb": "FAM83H",
        "gene_names_refseq": "AI3A; AI3; FAM83H; SACK1H",
        "protein_names_uniprotkb": "Protein FAM83H",
        "protein_names_refseq": "family with sequence similarity 83 member H; protein FAM83H",
        "tax_id": 9606,
        "disease": "amelogenesis imperfecta type 3A (Disease Ontology:DOID:0110055)",
        "pathway": " (hsa:286077)",
        "pathway_count": 1,
        "publication_count": 54,
        "publication_id_list": "11237011;17081983;18252228;18452278;18484629;18669648;18691976;19220331;19369195;19407157;19415658;19651622;19664995;19691289;20068231;20112406;20166139;20230923;22544926;23186163;23902688;24275569;25576301;25645385;26142250;26992070;29242379;29393594;29493099;29557506;29789297;29789417;30484775;32157095;32161166;32387766;32488085;32938616;33537174;33968037;33981976;34087483;34171305;34185709;35051231;35580925;36010968;36171592;36215666;36241641;36284347;36318336;37615776;37659852",
        "class_list": "",
        "function": "Affected individuals having truncating FAMH3H mutations of 677 or fewer amino acids presented a generalized autosomal-dominant hypocalcified amelogenesis imperfecta phenotype. A unique and previously unreported phenotype is also described., [RefSeq, PubMed]; Amelogenesis imperfecta in a Chinese family resulting from a FAM83H variation and the effect of FAM83H on the secretion of enamel matrix proteins., [RefSeq, PubMed]; FAM83H mutations in families with autosomal-dominant hypocalcified amelogenesis imperfecta demonstrate that FAM83H is required for proper dental-enamel calcification., [RefSeq, PubMed]; Identified FAM83H nonsense mutations in all eight families with autosomal dominant hypocalcified amelogenesis imperfecta, [RefSeq, PubMed]; LncRNA FAM83H-AS1 promotes the malignant progression of pancreatic ductal adenocarcinoma by stabilizing FAM83H mRNA to protect beta-catenin from degradation. Publication Status: Online-Only, [RefSeq, PubMed]; May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688)., [UniProtKB, PubMed, PubMed]; The C-terminal portion of FAM83H is required for tooth enamel calcification, [RefSeq, PubMed]; The protein encoded by this gene plays an important role in the structural development and calcification of tooth enamel. Defects in this gene are a cause of amelogenesis imperfecta type 3 (AI3). [provided by RefSeq, Mar 2010]., [RefSeq]; Tooth ultrastructure changes induced by a nonsense mutation in the FAM83H gene: insights into the diversity of amelogenesis imperfecta., [RefSeq, PubMed]; [Analysis of amelogenesis imperfecta with abnormal tooth eruption caused by FAM83H mutation]., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 53,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0JLS2;Q8N4W0",
        "ec_number_list": "",
        "go_molecular_function": "GO:1990254 keratin filament binding;GO:0019901 protein kinase binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0007165 signal transduction;GO:0030335 positive regulation of cell migration;GO:0044380 protein localization to cytoskeleton;GO:0031214 biomineral tissue development;GO:0045104 intermediate filament cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "Q6ZRV2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O76042-1",
        "uniprot_id": "ERIT1_HUMAN",
        "mass": 14968.0,
        "length": 136,
        "protein_name": "Putative uncharacterized protein encoded by ERC2-IT1",
        "gene_name": "ERC2-IT1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "ERC2-IT1; C1orf1; C3orf51",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative uncharacterized protein encoded by ERC2-IT1; ERC2 intronic transcript protein 1; PO42",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "9653645",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6NT35",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "O76042-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95718-3",
        "uniprot_id": "ERR2_HUMAN",
        "mass": 48054.0,
        "length": 433,
        "protein_name": "Steroid hormone receptor ERR2",
        "gene_name": "ESRRB",
        "organism": "Human",
        "refseq_name": "steroid hormone receptor ERR2 isoform 1",
        "refseq_ac": "NP_004443",
        "gene_names_uniprotkb": "ESRRB; ERRB2; ESRL2; NR3B2",
        "gene_names_refseq": "DFNB35; ERR beta-2; ERR2; ERRbeta2; ERRb; ESRL2; ESRRB; NR3B2",
        "protein_names_uniprotkb": "Steroid hormone receptor ERR2; ERR beta-2; ERR-beta; Estrogen receptor-like 2; Estrogen-related receptor beta; Nuclear receptor subfamily 3 group B member 2",
        "protein_names_refseq": "estrogen receptor-like 2; estrogen-related nuclear receptor beta; nuclear receptor ERRB2; nuclear receptor subfamily 3 group B member 2; orphan nuclear receptor; steroid hormone receptor ERR2 isoform 1; steroid hormone receptor ERR2",
        "tax_id": 9606,
        "disease": "autosomal recessive nonsyndromic deafness 35 (Disease Ontology:DOID:0110493); dilated cardiomyopathy (Disease Ontology:DOID:12930); azoospermia (Disease Ontology:DOID:14227); cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:2103);  (R-HSA-383280)",
        "pathway_count": 2,
        "publication_count": 27,
        "publication_id_list": "10072763;10235266;10542397;11865025;12654265;15175151;15896744;16332939;16751179;17920186;18179891;18775884;19755138;20484414;23836911;27363015;31848261;32938616;33968037;35051231;35101039;35580925;37222961;37350664;38421553;39261511;9653119",
        "class_list": "",
        "function": "A novel missense variant in ESRRB gene causing autosomal recessive non-syndromic hearing loss: in silico analysis of a case. Publication Status: Online-Only, [RefSeq, PubMed]; ESRRB Inhibits the TGFbeta Signaling Pathway to Drive Cell Proliferation in Cervical Cancer., [RefSeq, PubMed]; Functional pathogenicity of ESRRB variant of uncertain significance contributes to hearing loss (DFNB35). Publication Status: Online-Only, [RefSeq, PubMed]; Long Noncoding RNA ACTA2-AS1 Inhibits Cell Growth and Facilitates Apoptosis in Gastric Cancer by Binding with miR-6720-5p to Regulate ESRRB., [RefSeq, PubMed]; SIRT1 mediates breast cancer development and tumorigenesis controlled by estrogen-related receptor beta., [RefSeq, PubMed]; This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity. Positively regulates ESR1 transcriptional activity upon E2 stimulation., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2VDJ2;B6ZGU4;Q5F0P7;Q5F0P8;Q9HCB4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000793 condensed chromosome;GO:0000785 chromatin",
        "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008283 cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "O95718-3",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95925-1",
        "uniprot_id": "EPPI_HUMAN",
        "mass": 15284.0,
        "length": 133,
        "protein_name": "Eppin",
        "gene_name": "EPPIN-WFDC6; EPPIN; WFDC6",
        "organism": "Human",
        "refseq_name": "eppin isoform 2 precursor",
        "refseq_ac": "NP_001289790",
        "gene_names_uniprotkb": "EPPIN-WFDC6; EPPIN; WFDC6; C20orf171; SPINLW1; WAP6; WAP7; WFDC7",
        "gene_names_refseq": "CT71; CT72; EPPIN; SPINLW1; WAP7; WFDC7; dJ461P17.2",
        "protein_names_uniprotkb": "Eppin; CT71; Cancer/testis antigen 71; Epididymal protease inhibitor; Protease inhibitor WAP7; Serine protease inhibitor-like with Kunitz and WAP domains 1; WAP four-disulfide core domain protein 7",
        "protein_names_refseq": "WAP four-disulfide core domain protein 7; cancer/testis antigen 71; cancer/testis antigen 72; epididymal protease inhibitor; epididymis secretory sperm binding protein; eppin isoform 2 precursor; protease inhibitor WAP7; serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100526773);  (hsa:140870);  (hsa:57119);  (R-HSA-6803157)",
        "pathway_count": 4,
        "publication_count": 70,
        "publication_id_list": "11120840;11237011;11313366;11389039;11404006;11971875;12206714;12493837;13816;14506276;14739326;1522221;15229136;15590901;15778384;15826377;15956276;16054449;16215847;16336202;16354652;16354654;16374474;16799473;16931762;16940129;17363965;17502600;17567961;17644992;17964057;18021746;18160480;18185531;18331357;18673279;19095652;19179970;19254208;19818633;20005859;20103720;20180804;20382864;20395631;20510021;20845358;21461566;21787330;22262861;22327069;22455996;22699487;22701042;23302724;23426625;24219363;24256734;24312623;24358212;25075772;25461571;25596890;26148048;27089320;28705940;3286634;9523110;9665269;9756476",
        "class_list": "",
        "function": "EPPIN and SEMG1 rapidly co-evolved in primates Publication Status: Online-Only, [RefSeq, PubMed]; Eppin and Fibronectin bind to each other in human semen and on human ejaculated spermatozoa. Publication Status: Online-Only, [RefSeq, PubMed]; Eppin plays a role outside of the reproductive tract; eppin may have a role in the innate immune response in the lung Publication Status: Online-Only, [RefSeq, PubMed]; In seminal plasma and on spermatozoa following ejaculation, Eppin is bound to semenogelin I, [RefSeq, PubMed]; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; This antimicrobial peptide permeabilized outer and inner membranes of E. coli, consistent with its ability to induce striking morphological alterations of E. coli membranes. Has role in innate immune system of human epididymis., [RefSeq, PubMed]; This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility and exhibits antimicrobial activity against E. coli, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6PVD6;Q86TP9;Q96SD7;Q9HD30",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0001669 acrosomal vesicle;GO:0097524 sperm plasma membrane;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0090281 negative regulation of calcium ion import;GO:1901318 negative regulation of flagellated sperm motility;GO:0010466 negative regulation of peptidase activity;GO:0042742 defense response to bacterium",
        "synthesized_glycan_count": 0,
        "hit_score": 7.1,
        "record_id": "O95925-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95936-1",
        "uniprot_id": "EOMES_HUMAN",
        "mass": 72732.0,
        "length": 686,
        "protein_name": "Eomesodermin homolog",
        "gene_name": "EOMES",
        "organism": "Human",
        "refseq_name": "eomesodermin homolog isoform 1",
        "refseq_ac": "NP_001265111",
        "gene_names_uniprotkb": "EOMES; TBR2",
        "gene_names_refseq": "EOMES; TBR2",
        "protein_names_uniprotkb": "Eomesodermin homolog; T-box brain protein 2; T-brain-2; TBR-2",
        "protein_names_refseq": "T-box brain protein 2; eomesodermin homolog isoform 1; eomesodermin homolog",
        "tax_id": 9606,
        "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); Bell's palsy (Disease Ontology:DOID:12506); aggressive periodontitis (Disease Ontology:DOID:1474); epilepsy (Disease Ontology:DOID:1826); cholangiocarcinoma (Disease Ontology:DOID:4947); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); nasopharynx carcinoma (Disease Ontology:DOID:9261)",
        "pathway": " (hsa:8320);  (R-HSA-9733709);  (R-HSA-9754189);  (R-HSA-9758919);  (R-HSA-9823730);  (R-HSA-9827857)",
        "pathway_count": 6,
        "publication_count": 75,
        "publication_id_list": "10407135;10655587;15095414;15110706;16273099;16959974;17068183;17204604;17353897;17566017;18042803;18316326;18550259;18729794;19479054;19564924;21245162;21630377;21855631;25187301;25543152;25693565;25843708;25921273;25936800;26015544;26189426;26783251;27705785;27846572;27862975;28218747;28649982;28832583;28985527;29091993;29234012;29242379;29493099;29508533;29557506;29632711;29636455;29713018;29729076;29786170;30590035;30629940;30705751;31154438;31217245;31844290;32127035;32448362;32502341;32795420;32983136;33054971;33470497;33488348;33608411;33633747;34065661;34630413;34986510;35051231;35411086;35580925;35734162;37074911;37279078;38189779;40914422;9417125;9888994",
        "class_list": "",
        "function": "A key transcription factor that links the long-term renewal of memory CD8+ T cells to their characteristic effector potency. Erratum:[Nat Immunol. 2006 Jan;7(1):113], [RefSeq, PubMed]; Breakpoint on chromosome 3 silences the eomesodermin transcript (EOMES) leading to malformative microcephaly syndromes., [RefSeq, PubMed]; Describes cloning of the human TBR2 gene and compares the human and mouse protein sequences., [RefSeq, PubMed]; Eomes-dependent mitochondrial regulation promotes survival of pathogenic CD4+ T cells during inflammation., [RefSeq, PubMed]; Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex (PubMed:17353897). Required for differentiation and migration of unipolar dendritic brush cells (PubMed:33488348). Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes (PubMed:17566017)., [UniProtKB, PubMed, PubMed, PubMed]; T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells. Publication Status: Online-Only, [RefSeq, PubMed]; T-BET and EOMES sustain mature human NK cell identity and antitumor function. Publication Status: Online-Only, [RefSeq, PubMed]; The transcription factor Eomes promotes expression of inhibitory receptors on hepatic CD8(+) T cells during HBV persistence., [RefSeq, PubMed]; This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]., [RefSeq]; Transcriptional Pattern Analysis of Virus-Specific CD8+ T Cells in Hepatitis C Infection: Increased Expression of TOX and Eomesodermin During and After Persistent Antigen Recognition. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 7,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z4I2;B7ZA51;G3XAI5;Q8TAZ2;Q9UPM7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003714 transcription corepressor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0031490 chromatin DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0001714 endodermal cell fate specification;GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response;GO:0060706 cell differentiation involved in embryonic placenta development;GO:0060809 mesodermal to mesenchymal transition involved in gastrulation",
        "synthesized_glycan_count": 0,
        "hit_score": 8.0,
        "record_id": "O95936-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95990-1",
        "uniprot_id": "F107A_HUMAN",
        "mass": 17455.0,
        "length": 144,
        "protein_name": "Actin-associated protein FAM107A",
        "gene_name": "FAM107A",
        "organism": "Human",
        "refseq_name": "actin-associated protein FAM107A isoform a",
        "refseq_ac": "NP_001070246",
        "gene_names_uniprotkb": "FAM107A; DRR1; TU3A",
        "gene_names_refseq": "DRR1; FAM107A; TU3A",
        "protein_names_uniprotkb": "Actin-associated protein FAM107A; Down-regulated in renal cell carcinoma 1; Protein TU3A",
        "protein_names_refseq": "actin-associated protein FAM107A isoform a; actin-associated protein FAM107A; down-regulated in renal cell carcinoma 1; protein FAM107A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11170)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "10564580;10702698;11230166;11237011;11256614;16432833;18813805;20543869;21969592;28604741;30446454;31154438;31848261;33831429;35414505;37977035",
        "class_list": "",
        "function": "Both IQGAP3/BMP4 and IQGAP3/FAM107A ratios in ucfDNA were significantly higher in patients with BC than in those with hematuria., [RefSeq, PubMed]; Expression of the down-regulated in renal cell carcinoma gene (DRR1) gene at 3p14.2 was lost in 7 and down regulated in 2 'chr3+' tumours., [RefSeq, PubMed]; FAM107A as a Tumor Suppressor in Bladder Cancer Inhibits Cell Proliferation, Migration, and Invasion., [RefSeq, PubMed]; FAM107A as a tumor suppressor in esophageal squamous carcinoma inhibits growth and metastasis., [RefSeq, PubMed]; Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner (PubMed:20543869). Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner (PubMed:10564580, PubMed:28604741). May play a role in tumor development (PubMed:10564580)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; TU3A is epigenetically inactivated in human cancer, [RefSeq, PubMed]; Transcription factor SP1-induced microRNA-146b-3p facilitates the progression and metastasis of colorectal cancer via regulating FAM107A., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KNQ4;B7ZAY5;J3KR61;Q96NH4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0032956 regulation of actin cytoskeleton organization;GO:0050890 cognition;GO:1900272 negative regulation of long-term synaptic potentiation;GO:0051017 actin filament bundle assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "O95990-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0CH98-1",
        "uniprot_id": "F106C_HUMAN",
        "mass": 18676.0,
        "length": 169,
        "protein_name": "Protein FAM106C",
        "gene_name": "FAM106C",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "FAM106C; FAM106CP",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Protein FAM106C; FAM106C pseudogene",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "29557506;32488085",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "P0CH98-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0DI81-1",
        "uniprot_id": "TPC2A_HUMAN",
        "mass": 16445.0,
        "length": 140,
        "protein_name": "Trafficking protein particle complex subunit 2",
        "gene_name": "TRAPPC2",
        "organism": "Human",
        "refseq_name": "trafficking protein particle complex subunit 2 isoform 1",
        "refseq_ac": "NP_001011658",
        "gene_names_uniprotkb": "TRAPPC2; SEDL",
        "gene_names_refseq": "MIP2A; SEDL; SEDT; TRAPPC2P1; TRAPPC2; TRS20; ZNF547L; hYP38334",
        "protein_names_uniprotkb": "Trafficking protein particle complex subunit 2; Sedlin",
        "protein_names_refseq": "sedlin; trafficking protein particle complex 2; trafficking protein particle complex subunit 2 isoform 1",
        "tax_id": 9606,
        "disease": "X-linked spondyloepiphyseal dysplasia tarda (Disease Ontology:DOID:0080362); spondyloepiphyseal dysplasia congenita (Disease Ontology:DOID:14789)",
        "pathway": " (hsa:6399);  (R-HSA-204005);  (R-HSA-8876198)",
        "pathway_count": 3,
        "publication_count": 266,
        "publication_id_list": "10431248;10445031;10559959;10679020;10747087;10788476;10818110;10825291;10903204;10982397;10990452;11031107;11035026;11038176;11179213;11237011;11285137;11306556;11349230;11424925;11516400;11689439;11703925;11746448;11784320;11805826;11917121;11927603;12058051;12070132;12221131;12235121;12244319;12364329;12427552;12475894;12684051;12944476;12972505;14597397;15037235;15096524;15138286;1516130;15247254;15388334;15528189;15561770;15692570;15878329;15914536;15958533;16207721;16303754;16373702;16410077;16495487;16525024;16525121;16571673;16624868;16641372;16754960;16880209;16912714;16950109;17005010;17038314;17043139;17132146;17189207;17192411;17208202;17239822;17287728;17316621;17488286;17562788;17574030;17646400;17671165;17678623;17684057;18076383;18094055;18354496;18367545;1845915;18477474;18559336;18585354;18664496;18701652;18779367;18804435;18843296;1900457;19109890;19164740;19345684;19403694;19416478;19490898;19620288;19638414;19656848;19725050;19729655;19745841;20008558;20154091;20159109;20159556;20305638;20308558;20404108;20434987;20498720;20545907;20592283;20679433;20797862;20851765;20937701;20966969;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21478858;21525244;21532587;21554507;21586568;21683469;21689688;21706022;21718402;21776405;21951725;22013193;22065758;22072793;22157747;22171327;22365832;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22675024;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23186163;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23479643;23645161;23678941;23684622;23698585;23713133;23839779;23864707;24119662;24296415;24644286;24694596;24715725;24719330;24891604;24917561;24967941;25074980;25202031;25341920;25343031;25406594;25472813;25492864;25586378;25619252;25645385;25648148;25713415;25918224;25925668;26055712;26177209;26245486;26252088;26434594;26538022;26925400;26936971;27041585;27044746;27103185;27246931;27329675;27397612;27862975;28904123;29769354;30410026;30429286;30833945;31053099;31154438;31217245;31844290;32157095;32357974;32897882;34185709;35051231;35318648;35580925;36010968;7688123;7911226;8144603;8221884;8408203;8522602;8620540;8663406;8863739;9020086;9020161;9030515;9094723;9136770;9150144;9177194;9307973;9323142;9590177;9647643;9733780",
        "class_list": "",
        "function": "C.93+5G>A mutation in the TRAPPC2 gene is associated with X-linked spondyloepiphyseal dysplasia in a Chinese family., [RefSeq, PubMed]; Novel loss-of-function variants of TRAPPC2 manifesting X-linked spondyloepiphyseal dysplasia tarda: report of two cases Publication Status: Online-Only, [RefSeq, PubMed]; Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi., [UniProtKB]; Prevents transcriptional repression and induction of cell death by ENO1. May play a role in vesicular transport from endoplasmic reticulum to Golgi., [UniProtKB, UniProtKB]; The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NEG0;O14582;Q9HD16",
        "ec_number_list": "",
        "go_molecular_function": "GO:0044325 transmembrane transporter binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0001501 skeletal system development;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048208 COPII vesicle coating;GO:0006901 vesicle coating",
        "synthesized_glycan_count": 0,
        "hit_score": 26.7,
        "record_id": "P0DI81-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P15170-1",
        "uniprot_id": "ERF3A_HUMAN",
        "mass": 55756.0,
        "length": 499,
        "protein_name": "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A",
        "gene_name": "GSPT1",
        "organism": "Human",
        "refseq_name": "eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 3",
        "refseq_ac": "NP_001123479",
        "gene_names_uniprotkb": "GSPT1; ERF3A",
        "gene_names_refseq": "551G9.2; ETF3A; GSPT1; GST1; eRF3a",
        "protein_names_uniprotkb": "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A; 3.6.5.-; Eukaryotic peptide chain release factor subunit 3a; G1 to S phase transition protein 1 homolog; eRF3a",
        "protein_names_refseq": "G1 to S phase transition protein 1 homolog; eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 3; eukaryotic peptide chain release factor GTP-binding subunit ERF3A; eukaryotic peptide chain release factor subunit 3a; eukaryotic release factor 3a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2935);  (R-HSA-72764);  (R-HSA-9010553);  (R-HSA-975956);  (R-HSA-975957)",
        "pathway_count": 5,
        "publication_count": 134,
        "publication_id_list": "10358005;11237011;11331269;11532962;11544179;11546874;11551508;12417715;12554878;12718880;12832468;14527413;14636577;14742663;14973490;15034551;15546618;15721257;15987998;16186820;16209946;16284618;16452507;16601204;16622410;16777602;17053788;17352659;17363904;17803942;17893241;18066079;18230761;18256688;18423202;18447580;18447585;18524595;18539146;1861871;18657639;18974281;19060897;19150429;19359157;19417104;19417105;19478851;19503078;19556969;19706539;19859661;19909264;20023408;2006156;20418951;20479275;20691628;20817927;20930030;21029861;21145460;21419344;22424782;23085078;23217742;23234702;23301498;23746841;24486019;2511002;25242263;25502872;25576301;26154972;26992070;27846572;27863242;28510447;28832583;28904123;29557506;30379171;30484775;30682371;30779550;30833945;31154438;31217245;31530632;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33214551;33298915;33592498;33691108;33912179;33968037;34019948;34078123;34087483;34171305;34185709;34405274;34509645;34561969;34932366;35051231;35138101;35154160;35251023;35318648;35580925;35839920;36241641;36284347;36459303;38099479;38665916;39117611;40596516;40914422;7990965;9712840",
        "class_list": "",
        "function": "GSPT1 Functions as a Tumor Promoter in Human Liver Cancer., [RefSeq, PubMed]; GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:15987998, PubMed:19417105, PubMed:2511002, PubMed:27863242). GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:27863242). GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site (PubMed:16777602, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MicroRNA-508-3p regulates the proliferation of human lung cancer cells by targeting G1 to S phase transition 1 (GSPT1) protein., [RefSeq, PubMed]; Potential of GSPT1 as a novel target for glioblastoma therapy. Publication Status: Online-Only, [RefSeq, PubMed]; Vimentin binds to a novel tumor suppressor protein, GSPT1-238aa, encoded by circGSPT1 with a selective encoding priority to halt autophagy in gastric carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "J3KQG6;Q96GF2",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;4.2.99.18;3.6.1.-;3.6.4.13;3.6.5.4;3.1.3.16;2.7.11.1;3.1.-.-;3.6.-.-;5.6.2.3;5.6.2.5;3.6.1.15;3.6.1.62;3.6.1.6;3.6.1.42;2.1.1.-",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003747 translation release factor activity",
        "go_cellular_component": "GO:0018444 translation release factor complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome",
        "go_biological_process": "GO:0006449 regulation of translational termination;GO:0006415 translational termination;GO:0000082 G1/S transition of mitotic cell cycle;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006412 translation",
        "synthesized_glycan_count": 0,
        "hit_score": 13.7,
        "record_id": "P15170-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P22794-1",
        "uniprot_id": "EVI2A_HUMAN",
        "mass": 26213.0,
        "length": 236,
        "protein_name": "Protein EVI2A",
        "gene_name": "EVI2A",
        "organism": "Human",
        "refseq_name": "protein EVI2A isoform 1",
        "refseq_ac": "NP_001003927",
        "gene_names_uniprotkb": "EVI2A; EVDA; EVI2",
        "gene_names_refseq": "EVDA; EVI-2A; EVI2A; EVI2",
        "protein_names_uniprotkb": "Protein EVI2A; EVI-2A; Ecotropic viral integration site 2A protein homolog",
        "protein_names_refseq": "ecotropic viral integration site 2A protein homolog; protein EVI2A isoform 1; protein EVI2A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2123)",
        "pathway_count": 1,
        "publication_count": 36,
        "publication_id_list": "2117566;24190977;25880248;25892735;26154972;26992070;27846572;27862975;28832583;29242379;29493099;29508533;29557506;29632711;30429286;31154438;31217245;31774019;31844290;31848261;32157095;32357974;32387766;32488085;32502341;32733620;32983136;33298915;33592498;33691108;34509645;34932366;35051231;35580925;36284347;37812330",
        "class_list": "",
        "function": "Increased expression of ecotropic viral integration site 2A promotes osteosarcoma evolution through activating MEK/ERK pathway., [RefSeq, PubMed]; May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor., [UniProtKB]; Prognostic Value of DNA Methylation-Driven Genes in Clear Cell Renal Cell Carcinoma: A Study Based on Methylation and Transcriptome Analyses. Publication Status: Online-Only, [RefSeq, PubMed]; SMYD2 Imparts Gemcitabine Resistance to Pancreatic Adenocarcinoma Cells by Upregulating EVI2A., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5X2;B4DHX8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.8,
        "record_id": "P22794-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P49640-1",
        "uniprot_id": "EVX1_HUMAN",
        "mass": 42440.0,
        "length": 407,
        "protein_name": "Homeobox even-skipped homolog protein 1",
        "gene_name": "EVX1",
        "organism": "Human",
        "refseq_name": "homeobox even-skipped homolog protein 1 isoform 2",
        "refseq_ac": "NP_001291448",
        "gene_names_uniprotkb": "EVX1",
        "gene_names_refseq": "EVX-1; EVX1",
        "protein_names_uniprotkb": "Homeobox even-skipped homolog protein 1; EVX-1",
        "protein_names_refseq": "eve, even-skipped homeo box homolog 1; eve, even-skipped homeobox homolog 1; even-skipped homeo box 1 (homolog of Drosophila); homeobox even-skipped homolog protein 1 isoform 2; homeobox even-skipped homolog protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2128)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11237011;1684419;22178155;26552663;35051231;35580925;7499236",
        "class_list": "",
        "function": "Even-skipped homeobox 1 controls human embryonic stem cell differentiation by directly repressing Goosecoid expression., [RefSeq, PubMed]; Low EVX1 expression is Correlated with Aggressiveness of Esophageal Squamous Cell Carcinoma., [RefSeq, PubMed]; May play a role in the specification of neuronal cell types., [UniProtKB]; This gene encodes a member of the even-skipped homeobox family characterized by the presence of a homeodomain closely related to the Drosophila even-skipped (eve) segmentation gene of the pair-rule class. The encoded protein may play an important role as a transcriptional repressor during embryogenesis. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D199;B4DQJ0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0030424 axon;GO:0044297 cell body;GO:0000785 chromatin",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "P49640-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P58499-1",
        "uniprot_id": "FAM3B_HUMAN",
        "mass": 25982.0,
        "length": 235,
        "protein_name": "Protein FAM3B",
        "gene_name": "FAM3B",
        "organism": "Human",
        "refseq_name": "protein FAM3B isoform a precursor",
        "refseq_ac": "NP_478066",
        "gene_names_uniprotkb": "FAM3B; C21orf11; C21orf76; PRED44; PRO365",
        "gene_names_refseq": "2-21; C21orf11; C21orf76; FAM3B; ORF9; PANDER; PRED44",
        "protein_names_uniprotkb": "Protein FAM3B; Cytokine-like protein 2-21; PANDER; Pancreatic-derived factor",
        "protein_names_refseq": "D21M16SJHU19e; cytokine-like protein 2-21; family with sequence similarity 3 member B; pancreatic derived factor; protein FAM3B isoform a precursor; protein FAM3B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54097)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11237011;11707072;12160727;12975309;16114871;16249448;31844290;32442162;37105387;37847647",
        "class_list": "",
        "function": "Helices B and C and the second disulfide bond of PANDER are essential for PANDER-induced beta-cell death., [RefSeq, PubMed]; Identification of rare loss-of-function variants in FAM3B associated with non-syndromic orofacial clefts., [RefSeq, PubMed]; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner., [UniProtKB, PubMed]; Localized to the islets of Langerhans., [RefSeq, PubMed]; Loss of feedback regulation between FAM3B and androgen receptor driving prostate cancer progression., [RefSeq, PubMed]; PANDER is secreted from 2 types of pancreatic cells, glucose stimulates its secretion in beta cell and primary islets but not in alpha-cells, it is likely cosecreted with insulin, and structure and conformation is vital for PANDER secretion., [RefSeq, PubMed]; Upregulation of FAM3B Promotes Cisplatin Resistance in Gastric Cancer by Inducing Epithelial-Mesenchymal Transition. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005125 cytokine activity;GO:0030246 carbohydrate binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0007165 signal transduction;GO:0006915 apoptotic process;GO:0030073 insulin secretion",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "P58499-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P60509-1",
        "uniprot_id": "ERB1_HUMAN",
        "mass": 58521.0,
        "length": 514,
        "protein_name": "Endogenous retrovirus group PABLB member 1 Env polyprotein",
        "gene_name": "ERVPABLB-1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "ERVPABLB-1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Endogenous retrovirus group PABLB member 1 Env polyprotein; Endogenous retrovirus group PABLB member 1; Envelope polyprotein; HERV-R(b) Env protein; HERV-R(b)_3p24.3 provirus ancestral Env polyprotein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 4,
        "publication_id_list": "12970426;14557543;35051231;35580925",
        "class_list": "",
        "function": "Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties., [UniProtKB, PubMed]",
        "predicted_glycosites": 11,
        "predicted_n_glycosites": 11,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "P60509-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P61565-1",
        "uniprot_id": "ENK21_HUMAN",
        "mass": 79236.0,
        "length": 698,
        "protein_name": "Endogenous retrovirus group K member 21 Env polyprotein",
        "gene_name": "ERVK-21",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "ERVK-21",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Endogenous retrovirus group K member 21 Env polyprotein; EnvK1 protein; Envelope polyprotein; HERV-K_12q14.1 provirus ancestral Env polyprotein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 9,
        "publication_id_list": "12629516;12970426;14557543;15063128;30379171;33968037;35051231;35580925;7983737",
        "class_list": "",
        "function": "Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties., [UniProtKB, PubMed]; Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution., [UniProtKB]; Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity)., [UniProtKB]; SU mediates receptor recognition., [UniProtKB]; TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity)., [UniProtKB]; The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution., [UniProtKB]",
        "predicted_glycosites": 12,
        "predicted_n_glycosites": 11,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005198 structural molecule activity;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0004190 aspartic-type endopeptidase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005730 nucleolus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0051028 mRNA transport;GO:0075523 viral translational frameshifting;GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "P61565-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P61568-1",
        "uniprot_id": "ENK11_HUMAN",
        "mass": 21462.0,
        "length": 191,
        "protein_name": "Putative endogenous retrovirus group K member 11-1 Env polyprotein",
        "gene_name": "ERVK11-1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "ERVK11-1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative endogenous retrovirus group K member 11-1 Env polyprotein; Envelope polyprotein; HERV-K_1p13.3 provirus ancestral Env polyprotein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "P61568-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P62495-1",
        "uniprot_id": "ERF1_HUMAN",
        "mass": 49031.0,
        "length": 437,
        "protein_name": "Eukaryotic peptide chain release factor subunit 1",
        "gene_name": "ETF1",
        "organism": "Human",
        "refseq_name": "eukaryotic peptide chain release factor subunit 1 isoform 2",
        "refseq_ac": "NP_001243231",
        "gene_names_uniprotkb": "ETF1; ERF1; RF1; SUP45L1",
        "gene_names_refseq": "D5S1995; ERF1; ERF; ETF1; RF1; SUP45L1; TB3-1",
        "protein_names_uniprotkb": "Eukaryotic peptide chain release factor subunit 1; Eukaryotic release factor 1; Protein Cl1; TB3-1; eRF1",
        "protein_names_refseq": "eukaryotic peptide chain release factor subunit 1 isoform 2; eukaryotic peptide chain release factor subunit 1; polypeptide chain release factor 1; protein Cl1; sup45 (yeast omnipotent suppressor 45) homolog-like 1",
        "tax_id": 9606,
        "disease": "occupational asthma (Disease Ontology:DOID:0080820)",
        "pathway": " (hsa:2107);  (R-HSA-72764);  (R-HSA-9010553);  (R-HSA-9629569);  (R-HSA-975956);  (R-HSA-975957)",
        "pathway_count": 6,
        "publication_count": 190,
        "publication_id_list": "10.1101/2023.09.13.557529;10358005;10413110;10445876;10676813;11237011;11331269;11532962;11544179;11546874;11551508;12417715;12554878;12665801;12718880;12832468;1378441;14527413;14636577;14742663;14973490;15034551;1537561;15546618;15676025;15721257;16186820;16209946;16284618;16452507;16601204;16622410;16777602;17053788;17352659;17363904;17651434;17803942;17893241;17947579;18066079;18230761;18256688;18423202;18447580;18447585;18524595;18539146;1856229;1861871;18657639;18974281;19060897;19150429;19359157;19417104;19417105;19478851;19503078;19556969;19574390;19706539;19819225;19859661;19909264;20023408;2006156;20068231;20479275;20606008;20684070;20691628;20817927;20930030;21029861;21060799;21145460;21419344;22851697;23085078;23103944;23186163;23217742;23234702;23303181;23746841;24100311;24366607;24486019;24550447;24550462;24550463;24715725;25242263;25367160;25576301;25728928;25880248;26154972;26245381;26797129;26992070;27090790;27600516;27863242;27920218;28063628;28218747;28228285;28467828;28510447;28514659;28649982;28832583;28834231;28855257;28860189;28904123;29242379;29314611;29317506;29393594;29437277;29557506;29563586;29605689;29632046;29632711;29786170;29789417;29914368;29915238;30315122;30379171;30410026;30524438;30682371;31217245;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33214551;33298915;33592498;33633747;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34229054;34357683;34405274;34509645;34725712;34932366;35051231;35138101;35154160;35251023;35580925;36010968;36215666;36241641;36284347;36581221;36638793;37651229;38665916;39063238;39302247;40596516;40914422;6688526;7990965;9003791;9029102;9712840",
        "class_list": "",
        "function": "Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons (PubMed:10676813, PubMed:16777602, PubMed:24486019, PubMed:26245381, PubMed:27863242, PubMed:36638793, PubMed:7990965). The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:26245381, PubMed:27863242, PubMed:36638793). ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA (PubMed:26245381, PubMed:27863242, PubMed:36638793). Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site and mediate hydrolysis of peptidyl-tRNA (PubMed:10676813, PubMed:16777602, PubMed:26245381, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Functional Activity of Isoform 2 of Human eRF1. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 1,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6B4;D3DQC1;P46055;Q5M7Z7;Q96CG1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004045 peptidyl-tRNA hydrolase activity;GO:1990825 sequence-specific mRNA binding;GO:0008079 translation termination factor activity;GO:0003723 RNA binding;GO:0043022 ribosome binding",
        "go_cellular_component": "GO:0018444 translation release factor complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome",
        "go_biological_process": "GO:0006449 regulation of translational termination;GO:0002184 cytoplasmic translational termination;GO:0006415 translational termination;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006479 protein methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 19.8,
        "record_id": "P62495-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q03828-1",
        "uniprot_id": "EVX2_HUMAN",
        "mass": 47800.0,
        "length": 476,
        "protein_name": "Homeobox even-skipped homolog protein 2",
        "gene_name": "EVX2",
        "organism": "Human",
        "refseq_name": "homeobox even-skipped homolog protein 2",
        "refseq_ac": "NP_001073927",
        "gene_names_uniprotkb": "EVX2",
        "gene_names_refseq": "EVX-2; EVX2",
        "protein_names_uniprotkb": "Homeobox even-skipped homolog protein 2; EVX-2",
        "protein_names_refseq": "eve, even-skipped homeo box homolog 2; even-skipped homeo box 2 (homolog of Drosophila eve); homeobox even-skipped homolog protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:344191)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "1675198;25645385;29242379;35051231;38907278",
        "class_list": "",
        "function": "Amplifications of EVX2 and HOXD9-HOXD13 on 2q31 in mature cystic teratomas of the ovary identified by array comparative genomic hybridization may explain teratoma characteristics in chondrogenesis and osteogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is located at the 5' end of the HOXD gene cluster on chromosome 2. The encoded protein is a homeobox transcription factor that is related to the protein encoded by the Drosophila even-skipped (eve) gene, a member of the pair-rule class of segmentation genes. A 117 kb microdeletion at the 5' end of the HOXD gene cluster, which includes this gene and the HOXD9-HOXD13 genes, causes synpolydactyly, a dominantly inherited disease resulting in limb malformation. [provided by RefSeq, Sep 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q03828-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q04741-1",
        "uniprot_id": "EMX1_HUMAN",
        "mass": 31295.0,
        "length": 290,
        "protein_name": "Homeobox protein EMX1",
        "gene_name": "EMX1",
        "organism": "Human",
        "refseq_name": "homeobox protein EMX1",
        "refseq_ac": "NP_004088",
        "gene_names_uniprotkb": "EMX1",
        "gene_names_refseq": "EMX1",
        "protein_names_uniprotkb": "Homeobox protein EMX1; Empty spiracles homolog 1; Empty spiracles-like protein 1",
        "protein_names_refseq": "empty spiracles homolog 1; empty spiracles-like protein 1; homeobox protein EMX1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2016)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11237011;1352754;20887964;29263200;34016958;34171305;34364391;35051231;35849030;38446849",
        "class_list": "",
        "function": "EMX1 functions as a tumor inhibitor in spinal cord glioma through transcriptional suppression of WASF2 and inactivation of the Wnt/beta-catenin axis., [RefSeq, PubMed]; Empty spiracles homeobox genes EMX1 and EMX2 regulate WNT pathway activation in sarcomagenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Generation of human excitatory forebrain neurons by cooperative binding of proneural NGN2 and homeobox factor EMX1., [RefSeq, PubMed]; Regulation of sarcomagenesis by the empty spiracles homeobox genes EMX1 and EMX2. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q0D2P0;Q53T30;Q86XB0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development;GO:0007420 brain development;GO:0030182 neuron differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q04741-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q05BV3-1",
        "uniprot_id": "EMAL5_HUMAN",
        "mass": 219427.0,
        "length": 1969,
        "protein_name": "Echinoderm microtubule-associated protein-like 5",
        "gene_name": "EML5",
        "organism": "Human",
        "refseq_name": "echinoderm microtubule-associated protein-like 5 isoform 1",
        "refseq_ac": "NP_899243",
        "gene_names_uniprotkb": "EML5",
        "gene_names_refseq": "EMAP-2; EMAP-5; EML5; FAP16",
        "protein_names_uniprotkb": "Echinoderm microtubule-associated protein-like 5; EMAP-5",
        "protein_names_refseq": "echinoderm microtubule associated protein like 5; echinoderm microtubule-associated protein-like 5 isoform 1",
        "tax_id": 9606,
        "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723)",
        "pathway": " (hsa:161436)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "11237011;19531498;23481700;27600516;29557506;30379171;31844290;31848261;32387766;32897882;32938616;33968037;33981976;34087483;34171305;34509645;35051231;36010968;36241641;37938771",
        "class_list": "",
        "function": "May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EK59;Q5H9N6;Q6UYC9;Q6ZRP3;Q6ZT03",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008017 microtubule binding",
        "go_cellular_component": "GO:0005874 microtubule;GO:0005929 cilium;GO:0070062 extracellular exosome",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q05BV3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13822-1",
        "uniprot_id": "ENPP2_HUMAN",
        "mass": 98994.0,
        "length": 863,
        "protein_name": "Autotaxin",
        "gene_name": "ENPP2",
        "organism": "Human",
        "refseq_name": "autotaxin isoform 2 preproprotein",
        "refseq_ac": "NP_001035181",
        "gene_names_uniprotkb": "ENPP2; ATX; PDNP2",
        "gene_names_refseq": "ATX-X; ATX; AUTOTAXIN; ENPP2; LysoPLD; NPP2; PD-IALPHA; PDNP2",
        "protein_names_uniprotkb": "Autotaxin; 3.1.4.39; 3.1.4.4; E-NPP 2; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; Extracellular lysophospholipase D; LysoPLD",
        "protein_names_refseq": "E-NPP 2; autotaxin isoform 2 preproprotein; autotaxin-t; ectonucleotide pyrophosphatase/phosphodiesterase family member 2; extracellular lysophospholipase D; phosphodiesterase I/nucleotide pyrophosphatase 2; plasma lysophospholipase D",
        "tax_id": 9606,
        "disease": "proliferative diabetic retinopathy (Disease Ontology:DOID:13207)",
        "pathway": " (hsa:5168);  (R-HSA-199220)",
        "pathway_count": 2,
        "publication_count": 69,
        "publication_id_list": "10.1101/2023.09.13.557529;10329687;10334869;10567687;11158296;11237011;11559573;12176993;12354767;12757929;12815048;14500380;15700135;15769751;17242360;17307740;1733949;18175805;19429682;21183659;21240271;21393252;21505238;23481700;25502872;25645385;25880248;26371182;26375851;26992070;27322068;27754931;27846572;28414242;29391424;29493099;29557506;29741879;29789417;30315122;31004344;31154438;31844290;32157095;32234503;32350084;32357974;32502341;32938616;32983136;33123756;33298915;33912179;34357683;35051231;35154160;35580925;36284347;36983025;37074911;37392838;37770812;38095984;39134206;7982964;8579579;8586446;8934567;9516450",
        "class_list": "",
        "function": "Diagnostic value of serum autotaxin level in colorectal cancer., [RefSeq, PubMed]; Dual role of autotaxin as novel biomarker and therapeutic target in pancreatic neuroendocrine neoplasms., [RefSeq, PubMed]; Dysregulation of the LPC-ATX-LPA axis in autoimmune hepatitis is associated with monocyte activation., [RefSeq, PubMed]; Lysophospholipase D activity on oral mucosa cells in whole mixed human saliva involves in production of bioactive lysophosphatidic acid from lysophosphatidylcholine., [RefSeq, PubMed]; Secreted lysophospholipase D that hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:12354767, PubMed:14500380, PubMed:15769751, PubMed:26371182, PubMed:27754931). Its major substrate is lysophosphatidylcholine (PubMed:12176993, PubMed:14500380, PubMed:27754931). Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility (PubMed:14500380). Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:12176993, PubMed:15769751). Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation (PubMed:11559573). Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein (PubMed:1733949). May have a role in induction of parturition (PubMed:12176993). Possible involvement in cell proliferation and adipose tissue development (Probable). Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (PubMed:21393252). Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:21393252)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]., [RefSeq]; X-ray diffraction of autotaxin data were collected to 3.0 A resolution from a monoclinic crystal form belonging to space group C2, with unit-cell parameters a = 311.4, b = 147.9, c = 176.9 A, beta = 122.6 degrees, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 18,
        "disease_count": 1,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8UHA1;E9PHP7;Q13827;Q14555;Q15117;Q9UCQ8;Q9UCR0;Q9UCR1;Q9UCR2;Q9UCR3;Q9UCR4",
        "ec_number_list": "3.6.1.-;3.1.4.1;3.6.1.9;3.1.4.4;3.1.4.39;3.1.4.-",
        "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity;GO:0004630 phospholipase D activity;GO:0005044 scavenger receptor activity;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005576 extracellular region",
        "go_biological_process": "GO:0034638 phosphatidylcholine catabolic process;GO:0030149 sphingolipid catabolic process;GO:0006935 chemotaxis;GO:0006955 immune response;GO:0009395 phospholipid catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.1,
        "record_id": "Q13822-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q1W209-1",
        "uniprot_id": "ESRG_HUMAN",
        "mass": 24186.0,
        "length": 222,
        "protein_name": "Embryonic stem cell-related gene protein",
        "gene_name": "ESRG",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "ESRG; HESRG",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Embryonic stem cell-related gene protein; hES cell-related gene protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 4,
        "publication_id_list": "17803967;23628413;35051231;37217939",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q1W209-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q32P44-1",
        "uniprot_id": "EMAL3_HUMAN",
        "mass": 95197.0,
        "length": 896,
        "protein_name": "Echinoderm microtubule-associated protein-like 3",
        "gene_name": "EML3",
        "organism": "Human",
        "refseq_name": "echinoderm microtubule-associated protein-like 3 isoform 1",
        "refseq_ac": "NP_001287722",
        "gene_names_uniprotkb": "EML3",
        "gene_names_refseq": "ELP95; EMAP3; EMAP95; EML3",
        "protein_names_uniprotkb": "Echinoderm microtubule-associated protein-like 3; EMAP-3",
        "protein_names_refseq": "EMAP-3; echinoderm microtubule associated protein like 3; echinoderm microtubule-associated protein-like 3 isoform 1",
        "tax_id": 9606,
        "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723)",
        "pathway": " (hsa:256364)",
        "pathway_count": 1,
        "publication_count": 62,
        "publication_id_list": "11237011;16964243;18212344;18220336;18445686;18669648;18767875;19651622;19690332;19691289;20068231;20166139;21406692;23186163;23481700;24275569;24715725;25418920;25576301;25645385;25740311;26154972;26992070;27846572;27920218;28063628;28218747;28228285;28832583;28834231;28904123;29242379;29331515;29351928;29393594;29437277;29493099;29557506;29632046;29632711;30524438;30723163;31154438;31217245;31844290;32157095;32387766;32488085;32502341;32897882;32938616;33141586;33298915;33912179;34087483;34405274;34561969;34932366;35051231;35580925;36284347;39302247",
        "class_list": "",
        "function": "Functional analysis of EML3 demonstrates an important role for EML3 in correct metaphase chromosome alignment., [RefSeq, PubMed]; Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Results indicate that EML3 regulates mitotic spindle assembly and the kinetochore-MT connection by regulating MT-based MT nucleation and recruiting Augmin/gamma-TuRC to MTs., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ZQW7;Q8NA55",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008017 microtubule binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0015630 microtubule cytoskeleton;GO:0030496 midbody",
        "go_biological_process": "GO:0051301 cell division;GO:0000226 microtubule cytoskeleton organization;GO:0007080 mitotic metaphase chromosome alignment;GO:1901673 regulation of mitotic spindle assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "Q32P44-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q4KMX7-1",
        "uniprot_id": "F106A_HUMAN",
        "mass": 18795.0,
        "length": 169,
        "protein_name": "Protein FAM106A",
        "gene_name": "FAM106A",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "FAM106A",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Protein FAM106A",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9HAD1",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "Q4KMX7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5FWF5-1",
        "uniprot_id": "ESCO1_HUMAN",
        "mass": 94983.0,
        "length": 840,
        "protein_name": "N-acetyltransferase ESCO1",
        "gene_name": "ESCO1",
        "organism": "Human",
        "refseq_name": "N-acetyltransferase ESCO1",
        "refseq_ac": "NP_443143",
        "gene_names_uniprotkb": "ESCO1; EFO1; KIAA1911",
        "gene_names_refseq": "A930014I12Rik; CTF; ECO1; EFO1; ESCO1; ESO1",
        "protein_names_uniprotkb": "N-acetyltransferase ESCO1; 2.3.1.-; CTF7 homolog 1; ECO1 homolog 1; EFO1p; EFO1; ESO1 homolog 1; Establishment factor-like protein 1; Establishment of cohesion 1 homolog 1; hEFO1",
        "protein_names_refseq": "CTF7 homolog 1; ECO1 homolog 1; EFO1p; ESO1 homolog 1; N-acetyltransferase ESCO1; establishment factor-like protein 1; establishment of cohesion 1 homolog 1; hEFO1",
        "tax_id": 9606,
        "disease": "Roberts syndrome (Disease Ontology:DOID:5325)",
        "pathway": " (hsa:114799);  (R-HSA-2468052)",
        "pathway_count": 2,
        "publication_count": 52,
        "publication_id_list": "11237011;14576321;15821733;15837422;15958495;17525332;18411254;18452278;18614053;18669648;19074885;19907496;20068231;21111234;22101327;22885700;23186163;25772364;27112597;27803161;28218747;28832583;28847955;28904123;29237092;29242379;29393594;29557506;29789417;30379171;30620550;31844290;31935221;32065581;32157095;32357974;32387766;32555289;32938616;32983136;33691108;33912179;33936100;33968037;34171305;35051231;35318648;35580925;36010968;37217939;38253038;8291532",
        "class_list": "",
        "function": "Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Alternative catalytic residues in the active site of Esco acetyltransferases. Publication Status: Online-Only, [RefSeq, PubMed]; DDX11, ESCO1 and ESCO2 control different fractions of cohesin that are spatially and mechanistically separated. Publication Status: Online-Only, [RefSeq, PubMed]; Data indicate that Esco1 and Esco2 contribute to distinct and separable activities of cohesin in vertebrate cells., [RefSeq, PubMed]; EFO1 and EFO2 are targeted to different chromosome structures to help establish or maintain sister-chromatid cohesion, [RefSeq, PubMed]; ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesin(STAG1) from WAPL. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of the first full-length human ortholog of yeast Ctf7p and characterization of its enzymatic activity, localization and novel genetic composition, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; These studies reveal the molecular basis for SMC3 acetylation by ESCO1 and have broader implications for understanding the structure/function of non-histone acetyltransferases., [RefSeq, PubMed]; This study identified a molecular target for the acetyltransferase Eco1 and revealed that Smc3 acetylation is a conserved mechanism in regulating sister chromatid cohesion., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 22,
        "reported_glycation": 0,
        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0YJ11;B0YJ12;Q69YG4;Q69YS3;Q6IMD7;Q8N3Z5;Q8NBG2;Q96PX7",
        "ec_number_list": "2.3.1.48;2.3.1.-;2.7.11.1;2.3.1.57;2.3.1.259;2.3.1.80",
        "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0016407 acetyltransferase activity;GO:0008080 N-acetyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0005694 chromosome",
        "go_biological_process": "GO:0006275 regulation of DNA replication;GO:0007064 mitotic sister chromatid cohesion;GO:0007062 sister chromatid cohesion;GO:0018394 peptidyl-lysine acetylation;GO:0034421 post-translational protein acetylation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.0,
        "record_id": "Q5FWF5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6P6B1-1",
        "uniprot_id": "ERIC5_HUMAN",
        "mass": 39936.0,
        "length": 374,
        "protein_name": "Glutamate-rich protein 5",
        "gene_name": "ERICH5",
        "organism": "Human",
        "refseq_name": "glutamate-rich protein 5 isoform 2",
        "refseq_ac": "NP_001164277",
        "gene_names_uniprotkb": "ERICH5; C8orf47",
        "gene_names_refseq": "C8orf47; ERICH5",
        "protein_names_uniprotkb": "Glutamate-rich protein 5",
        "protein_names_refseq": "glutamate-rich protein 5 isoform 2; glutamate-rich protein 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:203111);  (R-HSA-9925563)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "29242379;30379171;32350084;32938616;33091337;33717175",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "G3V1K4;Q8N1L8",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q6P6B1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6SJ93-1",
        "uniprot_id": "F111B_HUMAN",
        "mass": 84674.0,
        "length": 734,
        "protein_name": "Serine protease FAM111B",
        "gene_name": "FAM111B",
        "organism": "Human",
        "refseq_name": "serine protease FAM111B isoform b",
        "refseq_ac": "NP_001136175",
        "gene_names_uniprotkb": "FAM111B; CANP",
        "gene_names_refseq": "CANP; FAM111B; POIKTMP",
        "protein_names_uniprotkb": "Serine protease FAM111B; 3.4.21.-; Cancer-associated nucleoprotein",
        "protein_names_refseq": "cancer-associated nucleoprotein; family with sequence similarity 111 member B; serine protease FAM111B isoform b; serine protease FAM111B",
        "tax_id": 9606,
        "disease": "hereditary sclerosing poikiloderma with tendon and pulmonary involvement (MONDO:MONDO:0014310)",
        "pathway": " (hsa:374393)",
        "pathway_count": 1,
        "publication_count": 75,
        "publication_id_list": "11237011;22645359;23481700;24268661;24714562;24715725;25418920;25576301;25802875;25880248;25892735;26154972;26375851;26495788;26992070;27600516;27846572;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632711;29769354;29789417;29930882;30315122;30375432;30379171;30524438;30779550;30833945;31217245;31530632;31844290;31848261;32157095;32161166;32357974;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34932366;35051231;35318648;35561310;35580925;36010968;36241641;37270349;37672204;37782700;38474092",
        "class_list": "",
        "function": "Data indicate a heterozygous germline in-frame deletion in the gene FAM111B protein (c.1261_1263delAAG, p.Lys421del) cosegregated with the phenotype., [RefSeq, PubMed]; Family with sequence similarity 111 member B contributes to tumor growth and metastasis by mediating cell proliferation, invasion, and EMT via transforming acidic coiled-coil protein 3/PI3K/AKT signaling pathway in hepatocellular carcinoma., [RefSeq, PubMed]; Mutations in FAM111B cause hereditary fibrosing poikiloderma with tendon contracture, myopathy, and pulmonary fibrosis., [RefSeq, PubMed]; One rare variant was found in a patient with SSc but has no functional or structural impact on the FAM111B gene. In this cohort, FAM111B gene mutations are not associated with SSc. Publication Status: Online-Only, [RefSeq, PubMed]; Overexpressed FAM111B degrades GSDMA to promote esophageal cancer tumorigenesis and cisplatin resistance., [RefSeq, PubMed]; Serine protease., [UniProtKB, UniProtKB]; Silencing of FAM111B inhibited proliferation, migration and invasion of hepatoma cells through activating p53 pathway., [RefSeq, PubMed]; This gene encodes a protein with a trypsin-like cysteine/serine peptidase domain in the C-terminus. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP). Affected individuals display mottled pigmentation, telangiectasia, epidermal atrophy, tendon contractures, and progressive pulmonary fibrosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A paralog of this gene which also has a trypsin&#8208;like peptidase domain, FAM111A, is located only 16 kb from this gene on human chromosome 11q12.1. [provided by RefSeq, Apr 2014]., [RefSeq]; Unravelling the Intricate Roles of FAM111A and FAM111B: From Protease-Mediated Cellular Processes to Disease Implications. Review article Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E2G2;Q6P661",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008236 serine-type peptidase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0005652 nuclear lamina",
        "go_biological_process": "GO:0006508 proteolysis;GO:0031297 replication fork processing;GO:0106300 protein-DNA covalent cross-linking repair",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "Q6SJ93-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6UWT2-1",
        "uniprot_id": "ENHO_HUMAN",
        "mass": 7927.0,
        "length": 76,
        "protein_name": "Adropin",
        "gene_name": "ENHO",
        "organism": "Human",
        "refseq_name": "adropin precursor",
        "refseq_ac": "NP_940975",
        "gene_names_uniprotkb": "ENHO; C9orf165; PRO830",
        "gene_names_refseq": "C9orf165; ENHO; UNQ470",
        "protein_names_uniprotkb": "Adropin; Energy homeostasis-associated protein",
        "protein_names_refseq": "GAAI470; adropin precursor; adropin; energy homeostasis-associated protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:375704)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "12975309;19041763;20837912;22318315;37990897;38348042",
        "class_list": "",
        "function": "A potential endothelial protective role of adropin that is likely mediated via upregulation of endothelial NO synthase expression through the VEGFR2-phosphatidylinositol 3-kinase-Akt and VEGFR2-extracellular signal regulated kinase 1/2 pathways. GeneRIF: Adropin has an endothelial protective function mediated via upregulation of eNOS expression through the VEGFR2-PI3K-Akt and VEGFR2-ERK1/2 pathways. Adropin therapy may thus be useful for limiting diseases characterized by endothelial dysfunction., [RefSeq, PubMed]; Adropin is the name given to the secreted peptide encoded by the ORF in C9orf165. In mice, it is abundant in liver where it is regulated by dietary macronutrients. Adropin regulates expression of genes involved in lipogenesis and adipogenesis., [RefSeq, PubMed]; Development and validation of a new diagnostic prediction model of ENHO and NOX4 for early diagnosis of systemic sclerosis. Publication Status: Online-Only, [RefSeq, PubMed]; High Level of Adropin Promotes the Progression of Pancreatic Ductal Adenocarcinoma., [RefSeq, PubMed]; Involved in the regulation of glucose homeostasis and lipid metabolism., [UniProtKB]; Plasma adropin levels are regulated dietary macronutrients increasing with dietary fat content. Fasting suppresses plasma adropin. Adropin's actions are required for preventing insulin resistance, dyslipidemia and impaired glucose tolerance., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N666",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005179 hormone activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0097009 energy homeostasis;GO:0045747 positive regulation of Notch signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q6UWT2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZMW3-1",
        "uniprot_id": "EMAL6_HUMAN",
        "mass": 217899.0,
        "length": 1958,
        "protein_name": "Echinoderm microtubule-associated protein-like 6",
        "gene_name": "EML6",
        "organism": "Human",
        "refseq_name": "echinoderm microtubule-associated protein-like 6",
        "refseq_ac": "NP_001034842",
        "gene_names_uniprotkb": "EML6; EML5L",
        "gene_names_refseq": "EML6",
        "protein_names_uniprotkb": "Echinoderm microtubule-associated protein-like 6; EMAP-6; Echinoderm microtubule-associated protein-like 5-like",
        "protein_names_refseq": "EMAP-6; echinoderm microtubule associated protein like 6; echinoderm microtubule-associated protein-like 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:400954)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "11237011;18691976;24715725;25645385;27231714;28218747;29437277;29557506;29605689;29786170;30192525;30379171;31217245;33298915;33691108;33912179;35051231;36010968;38253038",
        "class_list": "",
        "function": "Microtubule-associated protein that plays an important role in the regulation of oocyte meiotic progression by maintaining spindle integrity and facilitating proper chromosome alignment., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 53,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MUB5;B6ZDG7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008017 microtubule binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005874 microtubule",
        "go_biological_process": "GO:0051321 meiotic cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q6ZMW3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZT52-1",
        "uniprot_id": "FA43B_HUMAN",
        "mass": 36776.0,
        "length": 329,
        "protein_name": "Protein FAM43B",
        "gene_name": "FAM43B",
        "organism": "Human",
        "refseq_name": "protein FAM43B",
        "refseq_ac": "NP_997217",
        "gene_names_uniprotkb": "FAM43B",
        "gene_names_refseq": "FAM43B",
        "protein_names_uniprotkb": "Protein FAM43B",
        "protein_names_refseq": "protein FAM43B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:163933)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "21461611;30429286;31848261;35051231",
        "class_list": "",
        "function": "Expression of FAM43B, regulated by methylation and epigenetic silencing could contribute to hepatocellular carcinoma tumorigenesis by regulating cell proliferation, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5PKT8;A5PL01",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q6ZT52-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86XD5-1",
        "uniprot_id": "F131B_HUMAN",
        "mass": 35769.0,
        "length": 332,
        "protein_name": "Protein FAM131B",
        "gene_name": "FAM131B",
        "organism": "Human",
        "refseq_name": "protein FAM131B isoform a",
        "refseq_ac": "NP_001026860",
        "gene_names_uniprotkb": "FAM131B; KIAA0773",
        "gene_names_refseq": "FAM131B",
        "protein_names_uniprotkb": "Protein FAM131B",
        "protein_names_refseq": "protein FAM131B isoform a; protein FAM131B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9715);  (R-HSA-6802952)",
        "pathway_count": 2,
        "publication_count": 14,
        "publication_id_list": "11237011;15630448;18510355;18974108;20213681;20526349;21406692;21424530;22745804;23583981;24135138;24345920;25204415;25907612",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D2H6;A6NDW3;A8K605;B8ZZN2;D3DXE3;J3KQX2;Q7L0D6;Q86T97",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q86XD5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N7N1-1",
        "uniprot_id": "F86B1_HUMAN",
        "mass": 36787.0,
        "length": 330,
        "protein_name": "Putative protein N-methyltransferase FAM86B1",
        "gene_name": "FAM86B1",
        "organism": "Human",
        "refseq_name": "putative protein N-methyltransferase FAM86B1",
        "refseq_ac": "NP_001077006",
        "gene_names_uniprotkb": "FAM86B1",
        "gene_names_refseq": "FAM86B1",
        "protein_names_uniprotkb": "Putative protein N-methyltransferase FAM86B1; 2.1.1.-",
        "protein_names_refseq": "family with sequence similarity 86, member B1; protein FAM86B1; putative protein N-methyltransferase FAM86B1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:85002)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "26154972;27600516;28228285;28834231;30315122;33981976",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PN63",
        "ec_number_list": "",
        "go_molecular_function": "GO:0016279 protein-lysine N-methyltransferase activity",
        "go_cellular_component": "GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0032259 methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q8N7N1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N8S7-1",
        "uniprot_id": "ENAH_HUMAN",
        "mass": 66510.0,
        "length": 591,
        "protein_name": "Protein enabled homolog",
        "gene_name": "ENAH",
        "organism": "Human",
        "refseq_name": "protein enabled homolog isoform a",
        "refseq_ac": "NP_001008493",
        "gene_names_uniprotkb": "ENAH; MENA",
        "gene_names_refseq": "ENAH; ENA; MENA; NDPP1",
        "protein_names_uniprotkb": "Protein enabled homolog",
        "protein_names_refseq": "Mena delta 11a; protein enabled homolog isoform a; protein enabled homolog",
        "tax_id": 9606,
        "disease": "stomach cancer (Disease Ontology:DOID:10534); tauopathy (Disease Ontology:DOID:680); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:55740);  (R-HSA-202433);  (R-HSA-376176)",
        "pathway_count": 3,
        "publication_count": 103,
        "publication_id_list": "10.1101/2023.09.13.557529;10102266;10102268;10671560;10747096;10801818;10811803;10892742;11048639;11237011;11375980;11390650;11607830;11696321;11752630;12508280;12941633;14510693;15027125;15063764;15469845;15469846;16964243;17081983;17287340;17525332;17565045;17652306;17686488;18158903;18669648;19664995;20068231;20375348;21278383;21406692;23129656;23186163;24275569;27600516;28510447;28832583;28904123;29237092;29242379;29393594;29493099;29557506;29786170;29789417;30059200;30315122;30379171;30429286;30620550;31020640;31492838;31844290;32119511;32157095;32350084;32357974;32387766;32488085;32574038;32897882;32938616;32983136;33141586;33537174;33592498;33968037;34019948;34185709;34357683;34725712;35051231;35132862;35138101;35251023;35254053;35318648;35513511;35580925;36010968;36241641;36284347;37203597;37541260;37938771;38459605;38477606;38665916;38838015;39265883;39531497;40596516;7565724;8798379;8824201;9115214;9312002;9846482",
        "class_list": "",
        "function": "ENAH transcriptionally activated by YY1 promotes growth and invasion of laryngocarcinoma cells through PI3K/AKT signaling., [RefSeq, PubMed]; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Mammalian enabled protein enhances tamoxifen sensitivity of the hormone receptor-positive breast cancer patients by suppressing the AKT signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Mena as a key enhancer factor of EMT to promote metastasis of human tongue squamous cell carcinoma., [RefSeq, PubMed]; TRIM67 interacts with ENAH to regulate the apoptosis and autophagy of lung cancer cells., [RefSeq, PubMed]; This gene encodes a member of the enabled/ vasodilator-stimulated phosphoprotein. Members of this gene family are involved in actin-based motility. This protein is involved in regulating the assembly of actin filaments and modulates cell adhesion and motility. Alternate splice variants of this gene have been correlated with tumor invasiveness in certain tissues and these variants may serve as prognostic markers. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 3,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D0PQI2;Q502W5;Q5T5M7;Q5VTQ9;Q5VTR0;Q9NVF3;Q9UFB8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0050699 WW domain binding;GO:0005522 profilin binding",
        "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005925 focal adhesion",
        "go_biological_process": "GO:0070358 actin polymerization-dependent cell motility;GO:0008154 actin polymerization or depolymerization;GO:0007411 axon guidance;GO:0099188 postsynaptic cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 11.7,
        "record_id": "Q8N8S7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TAM6-1",
        "uniprot_id": "ERMIN_HUMAN",
        "mass": 32783.0,
        "length": 284,
        "protein_name": "Ermin",
        "gene_name": "ERMN",
        "organism": "Human",
        "refseq_name": "ermin isoform a",
        "refseq_ac": "NP_001009959",
        "gene_names_uniprotkb": "ERMN; KIAA1189",
        "gene_names_refseq": "ERMN; JN; KIAA1189",
        "protein_names_uniprotkb": "Ermin; JN; Juxtanodin",
        "protein_names_refseq": "ermin isoform a; ermin, ERM-like protein; juxtanodin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57471)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "11237011;16421295;19034380;19165527;20468071;20934411;25418920;26154972;28832583;29242379;29393594;29557506;29632046;31123898;31844290;34676516;35580925",
        "class_list": "",
        "function": "Expression Analysis of Ermin and Listerin E3 Ubiquitin Protein Ligase 1 Genes in the Periphery of Patients with Schizophrenia., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity)., [UniProtKB]; The results showed a significant decrease in ERMN expression in patients with relapsing-remitting multiple sclerosis compared with controls. The reduction in ERMN expression in leukocytes could be the cause of demyelinating process in RR-MS patients., [RefSeq, PubMed]; This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia., [RefSeq, PubMed]; This study suggested a role for hErmin as a novel cytoskeleton-related oligodendroglial protein in human brain myelination and human epileptogenesis, and provide new evidence for the relationship between oligodendrocytes and epilepsy., [RefSeq, PubMed]; Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DKA6;Q9ULN1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0051015 actin filament binding",
        "go_cellular_component": "GO:0033269 internode region of axon;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005938 cell cortex;GO:0043025 neuronal cell body",
        "go_biological_process": "GO:0031344 regulation of cell projection organization;GO:0007015 actin filament organization;GO:0008360 regulation of cell shape;GO:0001763 morphogenesis of a branching structure",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q8TAM6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TAY7-1",
        "uniprot_id": "F110D_HUMAN",
        "mass": 28710.0,
        "length": 271,
        "protein_name": "Protein FAM110D",
        "gene_name": "FAM110D",
        "organism": "Human",
        "refseq_name": "protein FAM110D",
        "refseq_ac": "NP_079145",
        "gene_names_uniprotkb": "FAM110D; GRRP1",
        "gene_names_refseq": "FAM110D; GRRP1",
        "protein_names_uniprotkb": "Protein FAM110D",
        "protein_names_refseq": "glycine/arginine-rich protein 1; protein FAM110D",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79927)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "31844290;31848261;33621312",
        "class_list": "",
        "function": "Three Novel Genetic Variants in the FAM110D, CACNA1A, and NLRP12 Genes Are Associated With Susceptibility to Hypertension Among Dai People., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K3V0;Q9H7Z4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q8TAY7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96CN4-1",
        "uniprot_id": "EVI5L_HUMAN",
        "mass": 91376.0,
        "length": 794,
        "protein_name": "EVI5-like protein",
        "gene_name": "EVI5L",
        "organism": "Human",
        "refseq_name": "EVI5-like protein isoform 1",
        "refseq_ac": "NP_001153416",
        "gene_names_uniprotkb": "EVI5L",
        "gene_names_refseq": "EVI5L",
        "protein_names_uniprotkb": "EVI5-like protein; Ecotropic viral integration site 5-like protein",
        "protein_names_refseq": "EVI5-like protein isoform 1; EVI5-like protein; ecotropic viral integration site 5-like protein; epididymis secretory sperm binding protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:115704)",
        "pathway_count": 1,
        "publication_count": 50,
        "publication_id_list": "11237011;16923123;18452278;19077034;23186163;23481700;24715725;25576301;25645385;25880248;27600516;27846572;27956704;28832583;28834231;28904123;29242379;29331515;29393594;29508533;29557506;29632046;29632711;30315122;30429286;30484775;30779550;31154438;31222486;31844290;31848261;31998317;32157095;32357974;32387766;32502341;32897882;32938616;32983136;33592498;33968037;33981976;34087483;34509645;34932366;35051231;35318648;35580925;36010968;36284347",
        "class_list": "",
        "function": "Functions as a GTPase-activating protein (GAP) with a broad specificity., [UniProtKB, PubMed]; Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9A6I9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding",
        "go_cellular_component": "",
        "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0043547 positive regulation of GTPase activity",
        "synthesized_glycan_count": 0,
        "hit_score": 5.1,
        "record_id": "Q96CN4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96J88-1",
        "uniprot_id": "ESIP1_HUMAN",
        "mass": 36793.0,
        "length": 318,
        "protein_name": "Epithelial-stromal interaction protein 1",
        "gene_name": "EPSTI1",
        "organism": "Human",
        "refseq_name": "epithelial-stromal interaction protein 1 isoform 1",
        "refseq_ac": "NP_001002264",
        "gene_names_uniprotkb": "EPSTI1",
        "gene_names_refseq": "BRESI1; EPSTI1",
        "protein_names_uniprotkb": "Epithelial-stromal interaction protein 1",
        "protein_names_refseq": "epithelial stromal interaction 1 (breast); epithelial-stromal interaction protein 1 isoform 1; epithelial-stromal interaction protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:94240);  (R-HSA-9696273)",
        "pathway_count": 2,
        "publication_count": 75,
        "publication_id_list": "10664463;11237011;11784792;11940653;11991720;12842009;15738000;16769699;18996843;19103606;20133812;20811643;21872626;21993680;23481700;24096480;24690281;25418920;25576301;25892735;26375851;26758079;26992070;27397612;27846572;27862975;27920218;28218747;28228285;28832583;28834231;28855257;28904123;29242379;29437277;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30083277;30315122;30379171;30429286;31154438;31217245;31844290;31848261;31871319;31998317;32157095;32387766;32502341;32938616;32983136;33141586;33298915;33392160;33592498;33912179;33936100;33968037;34738627;34932366;35051231;35318648;35527663;35580925;35778487;36284347;36330510;37938771;9531558",
        "class_list": "",
        "function": "A novel KLF8 to EPSTI1 to VCP to NF-kappaB signaling mechanism potentially critical for breast cancer invasion and metastasis., [RefSeq, PubMed]; CircEPSTI1,a significantly upregulated circRNA, which is derived from the EPSTI1 (epithelial stromal interaction 1) gene locus, is an independent prognostic marker for triple-negative breast cancer patient survival. Publication Status: Online-Only, [RefSeq, PubMed]; Contrasting functions of the epithelialstromal interaction 1 gene, in human oral and lung squamous cell cancers., [RefSeq, PubMed]; EPSTI1 as an immune biomarker predicts the prognosis of patients with stage III colon cancer. Publication Status: Online-Only, [RefSeq, PubMed]; EPSTI1 promotes monocyte adhesion to endothelial cells in vitro via upregulating VCAM-1 and ICAM-1 expression., [RefSeq, PubMed]; Knockdown of EPSTI1 alleviates lipopolysaccharide-induced inflammatory injury through regulation of NF-kappaB signaling in a cellular pneumonia model. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation (By similarity). Might play a role in RELA/p65 and STAT1 phosphorylation and nuclear localization upon activation of macrophages (By similarity)., [UniProtKB, UniProtKB]; The protein encoded by this gene has been shown to promote tumor invasion and metastasis in some invasive cancer cells when overexpressed. Expression of this gene has been shown to be upregulated by direct binding of the Kruppel like factor 8 protein to promoter sequences. The translated protein interacts with the amino terminal region of the valosin containing protein gene product, resulting in the nuclear translocation of the nuclear factor kappa B subunit 1 gene product, and activation of target genes. Overexpression of this gene has been observed in some breast cancers and in some individuals with systemic lupus erythematosus (SLE). [provided by RefSeq, Sep 2016]., [RefSeq]; These observations implicate EPSTI1 as a hitherto unappreciated regulator of tumor cell properties., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IVC7;Q8NDQ7",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "Q96J88-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96KD3-1",
        "uniprot_id": "GAR1B_HUMAN",
        "mass": 38946.0,
        "length": 344,
        "protein_name": "Golgi-associated RAB2 interactor protein 1B",
        "gene_name": "GARIN1B",
        "organism": "Human",
        "refseq_name": "Golgi-associated RAB2 interactor protein 1B isoform 2",
        "refseq_ac": "NP_001269717",
        "gene_names_uniprotkb": "GARIN1B; FAM137A; FAM71F1",
        "gene_names_refseq": "FAM137A; FAM71F1; GARI-L1; GARIL1; GARIN1B; NYD-SP18",
        "protein_names_uniprotkb": "Golgi-associated RAB2 interactor protein 1B; Testis development protein NYD-SP18",
        "protein_names_refseq": "Golgi associated RAB2 interactor protein 1B; Golgi-associated RAB2 interactor protein 1B isoform 2; Golgi-associated RAB2B interactor like 1; family with sequence similarity 137, member A; family with sequence similarity 71 member F1; protein FAM71F1; testes development-related NYD-SP18; testicular tissue protein Li 67; testis development protein NYD-SP18",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84691)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "11237011;18317470;26680676;26849538;27237450;27846572;29557506;30341978;31844290;33141586;35051231;36215666",
        "class_list": "",
        "function": "Decreased body weight in overweight/obese children is not significantly influenced by the NYD-SP18 rs6971091 or TMEM18 rs4854344 polymorphisms.  Gene Indexing Project Expand All Collapse All Decreased body weight in overweight/obese children is not significantly influenced by the NYD-SP18 rs6971091 or TMEM18 rs4854344 polymorphisms. Publication Status: Online-Only, [RefSeq, PubMed]; Genetic association studies in populations in Eastern Europe (Czech Republic, Lithuania, Poland, and Russia): Data suggest that an SNP in NYD-SP18 (rs6971091) is not associated with overweight/obesity in the adult populations studied (aged 45-75)., [RefSeq, PubMed]; Genetic variants within NYD-SP18 genes revealed a significant additive effect on BMI values in males., [RefSeq, PubMed]; Overweight/obese female carriers of the NYD-SP18 rs6971091 GG genotype exhibited a more beneficial response to the intensive lifestyle intervention than others., [RefSeq, PubMed]; RAB2B effector protein required for accurate acrosome formation and normal male fertility. In complex with RAB2A/RAB2B, seems to suppress excessive vesicle trafficking during acrosome formation., [UniProtKB, UniProtKB]; The effect of the NYD-SP18 SNP on obesity was larger than the effect of FTO in FHS. The NYD-SP18 gene is described as testes development related, but little is known about the gene's function or the mechanism by which it may influence risk for obesity. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IY75;Q8NA48",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0007340 acrosome reaction;GO:0001675 acrosome assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q96KD3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H6T0-1",
        "uniprot_id": "ESRP2_HUMAN",
        "mass": 78401.0,
        "length": 727,
        "protein_name": "Epithelial splicing regulatory protein 2",
        "gene_name": "ESRP2",
        "organism": "Human",
        "refseq_name": "epithelial splicing regulatory protein 2 isoform 1",
        "refseq_ac": "NP_079215",
        "gene_names_uniprotkb": "ESRP2; PP7059; RBM35B",
        "gene_names_refseq": "ESRP2; RBM35B",
        "protein_names_uniprotkb": "Epithelial splicing regulatory protein 2; RNA-binding motif protein 35B; RNA-binding protein 35B",
        "protein_names_refseq": "RNA binding motif protein 35A; RNA-binding motif protein 35B; RNA-binding protein 35B; epithelial splicing regulatory protein 2 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80004);  (R-HSA-6803529)",
        "pathway_count": 2,
        "publication_count": 33,
        "publication_id_list": "10938105;10982855;11237011;12393912;15498874;15601847;16410617;16449636;16603716;17959601;18573884;1906035;19285943;19829082;20711167;24275569;24715725;25576301;30484775;31844290;32387766;33384439;33968037;34087483;34520622;35051231;35318648;35580925;36241641;36284347;37985644;9271388;9858549",
        "class_list": "",
        "function": "ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]., [RefSeq]; ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing., [RefSeq, PubMed]; ESRP2 coordinates a complex alternative splicing network that adds an important post-transcriptional layer to the changes in gene expression that underlie epithelial-mesenchymal transitions during development and disease., [RefSeq, PubMed]; Genetic information from discordant sibling pairs points to ESRP2 as a candidate trans-acting regulator of the CF modifier gene SCNN1B. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of ESRP2 Activates TAK1-MAPK Signaling through the Fetal RNA-Splicing Program to Promote Hepatocellular Carcinoma Progression., [RefSeq, PubMed]; Results further establish ESRP1 and ESRP2 as global regulators of an epithelial splicing regulatory network., [RefSeq, PubMed]; The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor., [RefSeq, PubMed]; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2., [UniProtKB, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N6H8;Q8WZ15;Q9H6I4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003676 nucleic acid binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:1990904 ribonucleoprotein complex",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q9H6T0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9HC35-1",
        "uniprot_id": "EMAL4_HUMAN",
        "mass": 108916.0,
        "length": 981,
        "protein_name": "Echinoderm microtubule-associated protein-like 4",
        "gene_name": "EML4",
        "organism": "Human",
        "refseq_name": "echinoderm microtubule-associated protein-like 4 isoform b",
        "refseq_ac": "NP_001138548",
        "gene_names_uniprotkb": "EML4; C2orf2; EMAPL4",
        "gene_names_refseq": "C2orf2; ELP120; EMAP-4; EMAPL4; EML4; ROPP120",
        "protein_names_uniprotkb": "Echinoderm microtubule-associated protein-like 4; EMAP-4; Restrictedly overexpressed proliferation-associated protein; Ropp 120",
        "protein_names_refseq": "EML4/ALK fusion protein; echinoderm microtubule associated protein like 4; echinoderm microtubule-associated protein-like 4 isoform b; restrictedly overexpressed proliferation-associated protein; ropp 120",
        "tax_id": 9606,
        "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723)",
        "pathway": " (hsa:27436);  (R-HSA-9648025);  (R-HSA-9700645);  (R-HSA-9725370)",
        "pathway_count": 4,
        "publication_count": 203,
        "publication_id_list": "10216106;10556217;10702393;10706082;10706887;10934142;10995578;11110708;11237011;11280786;11310834;11504915;11751994;11850821;11943732;11988758;12112524;12185581;12424201;12679384;12750159;12800156;12852857;12920229;12934099;14962911;15169778;15208656;15302935;15374880;15588951;15592455;15895073;16153455;16161041;16170336;16825495;16871283;16890222;16939498;17081983;17086210;17185414;17196341;17322306;17353907;17416736;17483340;17625570;18083107;18097461;18166835;18242762;18452557;18491316;18593892;18594010;18669648;18701132;18724359;18923523;18923524;18923525;19007248;19413330;19415658;19456272;19459784;19651622;19664995;19690332;19691289;20068231;20166139;20454865;21134980;21164297;21213368;21406692;21415216;21494621;21502504;21596819;21656749;21838707;21847362;21948233;22249260;22327622;22347464;22570254;22658521;23104988;23139213;23186163;23201355;23239810;23301498;23481700;23661334;23957430;24060861;24275569;24445538;24475247;24496003;24518094;24613930;24675041;24715725;24736082;24842630;25228534;25342631;25393796;25418920;25421750;25576301;25740311;25789526;25813404;25880248;25921060;26001147;26062823;26154972;26301689;26464158;26939704;26992070;27245569;27452731;27573755;27600516;27874193;27920218;28218747;28404650;28510447;28649982;28657654;28659337;28741662;28832583;28834231;28904123;29242379;29393594;29437277;29455642;29493099;29508533;29557506;29632711;29786170;29873274;30131584;30315122;30410026;30429286;30524438;30692217;30779550;30833945;31154438;31217245;31366041;31388026;31409757;31530632;31844290;32157095;32161166;32357974;32488085;32938616;32983136;33214551;33298915;33592498;33912179;33968037;33981976;34087483;34171305;34357683;34561969;34661367;34725712;34783600;34932366;35051231;35074700;35254053;35580925;36010968;36284347;37938771;38665916;39488530;7824924;8633037;9819383",
        "class_list": "",
        "function": "EML4 is part of a fusion protein linked to histological characteristics in a subset of lung neoplasms., [RefSeq, PubMed]; EML4 negative cells showed a completely modified microtubule network, indicating that EML4 is necessary for correct microtubule formation., [RefSeq, PubMed]; EML4-ALK fusion gene product is involved in the carcinogenesis in non-small cell lung carcinomas, [RefSeq, PubMed]; Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526)., [UniProtKB, PubMed, PubMed, PubMed]; Malignant pleural mesothelioma with an EML4-ALK fusion: Expect the unexpected!, [RefSeq, PubMed]; Oncogenic EML4-ALK assemblies suppress growth factor perception and modulate drug tolerance. Publication Status: Online-Only, [RefSeq, PubMed]; Phase-separated foci of EML4-ALK facilitate signalling and depend upon an active kinase conformation., [RefSeq, PubMed]; The impact of the ALK fusion variant on clinical outcomes in EML4-ALK patients with NSCLC: a systematic review and meta-analysis., [RefSeq, PubMed]; This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 37,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6H8Y6;A6P4T4;A6P4V4;B2RBK3;B2RTW7;B5MCW9;Q3SWW0;Q53R29;Q53TW8;Q6PJ45;Q9NV40",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008017 microtubule binding;GO:0048487 beta-tubulin binding;GO:0043014 alpha-tubulin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0016020 membrane;GO:0015630 microtubule cytoskeleton",
        "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0000226 microtubule cytoskeleton organization;GO:0007080 mitotic metaphase chromosome alignment",
        "synthesized_glycan_count": 0,
        "hit_score": 20.7,
        "record_id": "Q9HC35-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9N2K0-1",
        "uniprot_id": "ENH1_HUMAN",
        "mass": 64318.0,
        "length": 584,
        "protein_name": "HERV-H_2q24.3 provirus ancestral Env polyprotein",
        "gene_name": "",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "HERV-H_2q24.3 provirus ancestral Env polyprotein; Env protein HERV-H/p62; Env protein HERV-H19; Env protein HERV-Hcl.3; Envelope polyprotein; HERV-H/env62",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 10,
        "publication_id_list": "10366582;11162811;11562544;12079564;12970426;14557543;24715725;33392160;35051231;36215666",
        "class_list": "",
        "function": "Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties but has immunosuppressive properties in vivo., [UniProtKB, PubMed, PubMed]; SU mediates receptor recognition., [UniProtKB]; TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity)., [UniProtKB]",
        "predicted_glycosites": 9,
        "predicted_n_glycosites": 8,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O00354;Q96L63;Q9UNM3",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q9N2K0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NQ30-1",
        "uniprot_id": "ESM1_HUMAN",
        "mass": 20095.0,
        "length": 184,
        "protein_name": "Endothelial cell-specific molecule 1",
        "gene_name": "ESM1",
        "organism": "Human",
        "refseq_name": "endothelial cell-specific molecule 1 isoform b precursor",
        "refseq_ac": "NP_001129076",
        "gene_names_uniprotkb": "ESM1",
        "gene_names_refseq": "ESM1; endocan",
        "protein_names_uniprotkb": "Endothelial cell-specific molecule 1; ESM-1",
        "protein_names_refseq": "ESM-1; endothelial cell-specific molecule 1 isoform b precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11082)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "11237011;11866539;20581009;20616313;23481700;29557506;31154438;31848261;32099535;32337544;38601985;38626010;38720298;38897128;38954708;8702785",
        "class_list": "glycogene",
        "function": "ESM1 enhances fatty acid synthesis and vascular mimicry in ovarian cancer by utilizing the PKM2-dependent warburg effect within the hypoxic tumor microenvironment. Publication Status: Online-Only, [RefSeq, PubMed]; Endothelial cell specific molecule 1 promotes epithelial-mesenchymal transition of cervical cancer via the E-box binding homeobox 1. Publication Status: Online-Only, [RefSeq, PubMed]; Esm-1 mediates transcriptional polarization associated with diabetic kidney disease., [RefSeq, PubMed]; Functional analysis of ESM1 by shRNA-mediated knockdown of its expression in papillary thyroid cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM., [RefSeq, PubMed]; Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions., [UniProtKB, PubMed]; Lactate drives the ESM1-SCD1 axis to inhibit the antitumor CD8[+] T-cell response by activating the Wnt/beta-catenin pathway in ovarian cancer cells and inducing cisplatin resistance., [RefSeq, PubMed]; This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 229,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R4G3;Q15330;Q3V4E3;Q96ES3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005171 hepatocyte growth factor receptor binding;GO:0005178 integrin binding;GO:0005201 extracellular matrix structural constituent",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:1902204 positive regulation of hepatocyte growth factor receptor signaling pathway;GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0002040 sprouting angiogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q9NQ30-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UKR5-1",
        "uniprot_id": "ERG28_HUMAN",
        "mass": 15864.0,
        "length": 140,
        "protein_name": "Ergosterol biosynthetic protein 28 homolog",
        "gene_name": "ERG28",
        "organism": "Human",
        "refseq_name": "ergosterol biosynthetic protein 28 homolog",
        "refseq_ac": "NP_009107",
        "gene_names_uniprotkb": "ERG28; AD-011; C14orf1; HSPC288; x0006",
        "gene_names_refseq": "C14orf1; ERG28; NET51",
        "protein_names_uniprotkb": "Ergosterol biosynthetic protein 28 homolog",
        "protein_names_refseq": "ergosterol biosynthetic protein 28 homolog; probable ergosterol biosynthetic protein 28",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11161)",
        "pathway_count": 1,
        "publication_count": 36,
        "publication_id_list": "10449901;10931946;11230166;20068231;20112406;21934552;24029068;25418920;25576301;25880248;25892735;26811146;27846572;28218747;28228285;28904123;29242379;29437277;29557506;30410026;31154438;31217245;31844290;31848261;32157095;32161166;32265295;32357974;32938616;33691108;33912179;33968037;34357683;35580925;36241641;36284347",
        "class_list": "",
        "function": "Data indicate that integrin beta6, CD46, tissue factor, and chromosome 14 open reading frame 1 (C14ORF1), were identified as overexpressed on pancreatic cancer cell lines., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9P093;Q9UPI2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030133 transport vesicle",
        "go_biological_process": "GO:0016126 sterol biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "Q9UKR5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UNN5-1",
        "uniprot_id": "FAF1_HUMAN",
        "mass": 73954.0,
        "length": 650,
        "protein_name": "FAS-associated factor 1",
        "gene_name": "FAF1",
        "organism": "Human",
        "refseq_name": "FAS-associated factor 1",
        "refseq_ac": "NP_008982",
        "gene_names_uniprotkb": "FAF1; CGI-03; UBXD12; UBXN3A",
        "gene_names_refseq": "CGI-03; FAF1; HFAF1s; UBXD12; UBXN3A; hFAF1",
        "protein_names_uniprotkb": "FAS-associated factor 1; UBX domain-containing protein 12; UBX domain-containing protein 3A; hFAF1",
        "protein_names_refseq": "FAS-associated factor 1; Fas (TNFRSF6) associated factor 1; TNFRSF6-associated factor 1; UBX domain protein 3A; UBX domain-containing protein 12; UBX domain-containing protein 3A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11124)",
        "pathway_count": 1,
        "publication_count": 84,
        "publication_id_list": "10.1101/2023.09.13.557529;10462485;11243799;11378439;11713579;15592455;18669648;18790738;19651622;19664994;19690332;19722279;20068231;21978668;22544926;23186163;23301498;23481700;23783831;24715725;25576301;25645385;25880248;26154972;26842564;26992070;27600516;27846572;27920218;28218747;28228285;28443643;28510447;28832583;28834231;28904123;29242379;29351928;29437277;29493099;29508533;29557506;29789417;30315122;30410026;30484775;30524438;31844290;32119511;32157095;32357974;32387766;32488085;32502341;32831099;32897882;32938616;32983136;33141586;33298915;33592498;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34255421;34464509;34644576;34932366;35051231;35318648;35561310;35580925;36215666;36241641;36284347;37938771;38665916;40914422",
        "class_list": "",
        "function": "A novel function of FAF1, which induces dopaminergic neuronal death through cell-to-cell transmission. Publication Status: Online-Only, [RefSeq, PubMed]; Association analysis of SNPs in GRHL3, FAF1, and KCNJ2 with NSCPO sub-phenotypes in Han Chinese., [RefSeq, PubMed]; FAF1 downregulation by Toxoplasma gondii enables host IRF3 mobilization and promotes parasite growth., [RefSeq, PubMed]; Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008]., [RefSeq]; USP7 and VCP(FAF1) define the SUMO/Ubiquitin landscape at the DNA replication fork., [RefSeq, PubMed]; Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q549F0;Q9UF34;Q9UNT3;Q9Y2Z3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0051059 NF-kappaB binding",
        "go_cellular_component": "GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum",
        "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0045732 positive regulation of protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.0,
        "record_id": "Q9UNN5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A8MUU1-1",
        "uniprot_id": "FB5L3_HUMAN",
        "mass": 11299.0,
        "length": 101,
        "protein_name": "Putative fatty acid-binding protein 5-like protein 3",
        "gene_name": "FABP5P3",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "FABP5P3; FABP5L3",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative fatty acid-binding protein 5-like protein 3; Fatty acid-binding protein 5 pseudogene 3",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 3,
        "publication_id_list": "29557506;31844290;32350084",
        "class_list": "",
        "function": "High specificity for fatty acids., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005504 fatty acid binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol",
        "go_biological_process": "GO:0015908 fatty acid transport",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "A8MUU1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A8MXZ1-1",
        "uniprot_id": "F90AN_HUMAN",
        "mass": 49910.0,
        "length": 464,
        "protein_name": "Protein FAM90A23",
        "gene_name": "FAM90A23",
        "organism": "Human",
        "refseq_name": "protein FAM90A23",
        "refseq_ac": "NP_001384309",
        "gene_names_uniprotkb": "FAM90A23; FAM90A23P",
        "gene_names_refseq": "FAM90A23P; FAM90A23",
        "protein_names_uniprotkb": "Protein FAM90A23",
        "protein_names_refseq": "family with sequence similarity 90 member A23, pseudogene; protein FAM90A23; putative protein FAM90A23P",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:645572)",
        "pathway_count": 1,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "A8MXZ1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "B1AL88-1",
        "uniprot_id": "NALF1_HUMAN",
        "mass": 51493.0,
        "length": 458,
        "protein_name": "NALCN channel auxiliary factor 1",
        "gene_name": "NALF1",
        "organism": "Human",
        "refseq_name": "NALCN channel auxiliary factor 1",
        "refseq_ac": "NP_001073865",
        "gene_names_uniprotkb": "NALF1; FAM155A; NLF-1",
        "gene_names_refseq": "FAM155A; NALF1; NLF-1; NLF1",
        "protein_names_uniprotkb": "NALCN channel auxiliary factor 1; Transmembrane protein FAM155A",
        "protein_names_refseq": "NALCN channel auxiliary factor 1; family with sequence similarity 155 member A; transmembrane protein FAM155A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:728215)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "29557506;32015353;32494638;32698188;32938616;33203861;33392160;34929720;35387979",
        "class_list": "",
        "function": "Auxilary subunit component of the NALCN channelosome complex, which regulates the resting membrane potential by depolarizing sodium leak currents (PubMed:32494638, PubMed:33203861, PubMed:35387979, PubMed:34929720). The NALCN channelosome complex is a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (PubMed:35387979, PubMed:34929720). The NALCN channelosome is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations (PubMed:32494638)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Common variation in FAM155A is associated with diverticulitis but not diverticulosis. Publication Status: Online-Only, [RefSeq, PubMed]; Structure of the human sodium leak channel NALCN in complex with FAM155A. Publication Status: Online-Only, [RefSeq, PubMed]; Structure of the human sodium leak channel NALCN., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RUV1;B7Z334",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0035725 sodium ion transmembrane transport;GO:0098703 calcium ion import across plasma membrane;GO:0098908 regulation of neuronal action potential",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "B1AL88-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "F5H4B4-1",
        "uniprot_id": "F227A_HUMAN",
        "mass": 66188.0,
        "length": 570,
        "protein_name": "Protein FAM227A",
        "gene_name": "FAM227A",
        "organism": "Human",
        "refseq_name": "protein FAM227A isoform 1",
        "refseq_ac": "NP_001013669",
        "gene_names_uniprotkb": "FAM227A",
        "gene_names_refseq": "FAM227A",
        "protein_names_uniprotkb": "Protein FAM227A",
        "protein_names_refseq": "Protein FAM227A; protein FAM227A isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:646851)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11237011;18477386;18669648;30379171;34087483;39531497",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0QY52;B7Z7C6;Q5TG08",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "F5H4B4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75426-1",
        "uniprot_id": "FBX24_HUMAN",
        "mass": 64889.0,
        "length": 580,
        "protein_name": "F-box only protein 24",
        "gene_name": "FBXO24",
        "organism": "Human",
        "refseq_name": "F-box only protein 24 isoform 4",
        "refseq_ac": "NP_001156971",
        "gene_names_uniprotkb": "FBXO24; FBX24",
        "gene_names_refseq": "FBX24; FBXO24",
        "protein_names_uniprotkb": "F-box only protein 24",
        "protein_names_refseq": "F-box only protein 24 isoform 4; F-box only protein 24; F-box protein Fbx24",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26261)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "10531035;11230166;11237011;25582197;32828318;33392160;35051231;37540490;38470475;38735474;39039092;40136647",
        "class_list": "",
        "function": "FBXO24 Suppresses Breast Cancer Tumorigenesis by Targeting LSD1 for Ubiquitination., [RefSeq, PubMed]; FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and male fertility. Publication Status: Online-Only, [RefSeq, PubMed]; FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration., [RefSeq, PubMed]; Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Specifically recognizes the deacetylated form of nucleoside diphosphate kinase A/NME1 and targets it for ubiquitin-mediated degradation (PubMed:25582197). Functions as a key regulator of cell proliferation by targeting PRMT6 for ubiquitination and proteasomal degradation, leading to cell cycle inhibition (PubMed:32828318). Also mediates 'Lys-6'-linked polyubiquitination of the mitochondrial S-adenosylmethionine transporter SLC25A26, targeting it for degradation and thereby maintaining mitochondrial function during spermiogenesis (By similarity). Promotes ubiquitination and degradation of mitochondrial aspartyl-tRNA synthetase DARS2, contributing to immunosuppressive activity (PubMed:39039092). In the nucleus, targets FOXK2 for ubiquitin-mediated degradation, a process that critically modulates mitochondrial respiration and cellular bioenergetics in lung epithelial cells (PubMed:38735474)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D2D4;B4DX91;B4DY42;Q9H0G1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004842 ubiquitin-protein transferase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0019005 SCF ubiquitin ligase complex;GO:0000151 ubiquitin ligase complex",
        "go_biological_process": "GO:0016567 protein ubiquitination;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "O75426-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O94952-2",
        "uniprot_id": "FBX21_HUMAN",
        "mass": 72270.0,
        "length": 628,
        "protein_name": "F-box only protein 21",
        "gene_name": "FBXO21",
        "organism": "Human",
        "refseq_name": "F-box only protein 21 isoform 2",
        "refseq_ac": "NP_055817",
        "gene_names_uniprotkb": "FBXO21; FBX21; KIAA0875",
        "gene_names_refseq": "FBX21; FBXO21",
        "protein_names_uniprotkb": "F-box only protein 21",
        "protein_names_refseq": "F-box only protein 21 isoform 2; F-box only protein 21",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23014);  (R-HSA-8951664);  (R-HSA-983168)",
        "pathway_count": 3,
        "publication_count": 203,
        "publication_id_list": "10531035;10535940;10597293;10811609;10878807;10973499;11062501;11069780;11230166;11259415;11292861;11292862;11350924;11454738;11585840;11733065;11961546;12101228;12186903;12504025;12504026;12526791;12538644;12609982;12646216;12682069;12759363;12816948;14690597;14734113;14757770;15224091;15224092;15282312;15361859;15367669;15537541;15571818;15572695;15574592;15601839;15652483;15688063;15694336;15799966;16171779;16401342;16547496;16595681;16647857;16707496;16790436;16849449;16943200;16954532;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18093314;18206966;18662542;18775313;18776931;18805092;18826954;18851830;18926707;19028597;19250909;19321346;19352404;19452197;19489725;19617556;19748355;19851334;19874575;19940261;20068231;20112406;21447816;21463634;21778237;21863050;21940857;22306028;22466964;22537386;2261476;22959436;23201271;23333871;23401859;23453757;23481700;23535662;23535663;23563313;23583660;23912815;23986495;24076655;24366543;24636985;24714562;24715725;24793695;24793696;25314029;25349211;25355947;25418920;25531226;25645385;25880248;25892735;26085330;26154972;26299618;26344709;26375851;26460955;26632597;26728094;26906416;27030794;27222660;27397612;27565346;27600516;27846572;27862975;27920218;28063628;28115426;28218747;28228285;28832583;28834231;28904123;29153394;29242379;29393594;29437277;29557506;29632046;29632711;29769354;29786170;30315122;30429286;30484775;30524438;30610225;30779550;30833945;31092671;31154438;31217245;31222486;31844290;31848261;32005965;32157095;32161166;32284348;32350084;32357974;32387766;32488085;32502341;32938616;33141586;33444648;33537174;33592498;33717175;33912179;33968037;33981976;34087483;34171305;35051231;35318648;35580925;36010968;36215666;36241641;36278814;36284347;36580660;36581221;37689825;37938771;9380723;9668046;9790970;9887101;9891082",
        "class_list": "",
        "function": "CircRNA-MSR regulates the expression of FBXO21 to inhibit chondrocyte autophagy by targeting miR-761 in osteoarthritis., [RefSeq, PubMed]; FBXO21 mediated degradation of p85alpha regulates proliferation and survival of acute myeloid leukemia., [RefSeq, PubMed]; Ser291-phosphorylated form of the multifunctional protein and stem cell marker, CD44, inhibits FBXO21-directed degradation of P-gp., [RefSeq, PubMed]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex., [UniProtKB]; The results suggest that EID1 is a bona fide substrate of FBXO21 and that the control of EID1 abundance by SCF(FBXO)(21) might affect the transcriptional repression activity of EID1., [RefSeq, PubMed]; This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KMF0;Q5BJG0;Q9H087",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex",
        "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 20.6,
        "record_id": "O94952-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0C841-1",
        "uniprot_id": "FA66E_HUMAN",
        "mass": 5233.0,
        "length": 47,
        "protein_name": "Putative protein FAM66E",
        "gene_name": "FAM66E",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "FAM66E",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative protein FAM66E",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "P0C841-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0DMU3-1",
        "uniprot_id": "F231L_HUMAN",
        "mass": 18266.0,
        "length": 169,
        "protein_name": "FAM231A/C-like protein LOC102723383",
        "gene_name": "",
        "organism": "Human",
        "refseq_name": "FAM231A/C-like protein LOC102723383",
        "refseq_ac": "XP_047292865",
        "gene_names_uniprotkb": "",
        "gene_names_refseq": "LOC124903857",
        "protein_names_uniprotkb": "FAM231A/C-like protein LOC102723383",
        "protein_names_refseq": "FAM231A/C-like protein LOC102723383",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:124903857);  (hsa:124905556)",
        "pathway_count": 2,
        "publication_count": 1,
        "publication_id_list": "29351928",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "P0DMU3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0DP71-1",
        "uniprot_id": "F236C_HUMAN",
        "mass": 8682.0,
        "length": 79,
        "protein_name": "Protein FAM236C",
        "gene_name": "FAM236C",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "FAM236C",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Protein FAM236C",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:105373251);  (hsa:109729126)",
        "pathway_count": 2,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "P0DP71-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P22455-1",
        "uniprot_id": "FGFR4_HUMAN",
        "mass": 87954.0,
        "length": 802,
        "protein_name": "Fibroblast growth factor receptor 4",
        "gene_name": "FGFR4",
        "organism": "Human",
        "refseq_name": "fibroblast growth factor receptor 4 isoform 3 precursor",
        "refseq_ac": "NP_001278909",
        "gene_names_uniprotkb": "FGFR4; JTK2; TKF",
        "gene_names_refseq": "CD334; FGFR4; JTK2; TKF",
        "protein_names_uniprotkb": "Fibroblast growth factor receptor 4; 2.7.10.1; FGFR-4",
        "protein_names_refseq": "fibroblast growth factor receptor 4 isoform 3 precursor; hydroxyaryl-protein kinase; protein-tyrosine kinase; tyrosine kinase related to fibroblast growth factor receptor; tyrosylprotein kinase",
        "tax_id": 9606,
        "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); bone disease (Disease Ontology:DOID:0080001); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); colon cancer (Disease Ontology:DOID:219); high grade glioma (Disease Ontology:DOID:3070); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); liver cirrhosis (Disease Ontology:DOID:5082); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); nasopharynx carcinoma (Disease Ontology:DOID:9261)",
        "pathway": " (hsa:2264);  (R-HSA-109704);  (R-HSA-1257604);  (R-HSA-1307965);  (R-HSA-1839128);  (R-HSA-190322);  (R-HSA-2219530);  (R-HSA-5654228);  (R-HSA-5654712);  (R-HSA-5654719);  (R-HSA-5654720);  (R-HSA-5654733);  (R-HSA-5655291);  (R-HSA-5673001);  (R-HSA-6811558)",
        "pathway_count": 15,
        "publication_count": 257,
        "publication_id_list": "10.1101/2023.09.13.557529;10191262;10508167;10579907;10629055;10631118;10652257;10869344;10918587;11027663;11090077;11136978;11147812;11157491;11237011;11278860;11294897;11313946;11353842;11429702;11433297;11447289;11546808;11689702;11702783;11739186;11781352;11803464;11830541;11997436;12032311;12094235;12121613;12167717;12419216;12660731;12767043;12815057;12974390;1325671;1379698;1381348;14506247;14534538;14707138;14710228;15094036;15340161;15356145;15448205;1545823;15546878;15718470;15834429;15863029;15863030;16012724;16061909;16091734;16339315;16456541;1656221;16597617;16627759;16647110;16684964;16844695;16847462;17088904;1709094;1716764;17200115;17227708;17311277;17339340;17344846;17505008;17519899;17623664;17626883;17998941;18056464;18079394;18317450;18337450;18373495;18381441;18452557;18480409;18552176;18594509;18606717;18670643;18691976;18754654;18755892;18756523;18757403;18775330;18829560;18840094;18925875;1898771;19063940;19103595;19147536;19185485;19187780;19279408;19296538;19381019;19411071;19438505;19576174;19644473;19652666;19749790;19805105;19809159;19918264;19920141;19946327;19962665;20018895;20066896;20080590;20094046;20127014;20179196;20231295;20338997;20478380;20522708;20638838;20683963;20709759;20713702;20798051;20844967;20876804;21102635;21160078;21188471;21317208;21349172;21368164;21372320;21412156;21478295;21625954;21653700;21666749;21668414;21711248;21779497;21779505;21827948;21882254;21976531;21984976;21993244;22120714;22188813;2247464;22569528;22588880;22589270;22750304;22802530;22986737;23090970;23103841;23186163;23226373;23303910;23443682;23575685;23901234;24190977;24275569;24381107;24897931;24937142;25219551;25548167;25576301;25781681;26085527;26675719;28063628;28467828;28778966;28904123;29221201;29242379;29391424;30459171;30524438;31135801;32161166;32350084;32983136;33968037;34087483;34211107;34357683;34932366;34981854;35003900;35051231;35251023;35318648;35580925;36142417;36215666;36923538;37817227;37945798;38796598;6148751;7518429;7543144;7559490;7637810;7680645;7744773;7809086;7935463;7972015;8052307;8264585;8394845;8493579;8576110;8622701;8645157;8657148;8663044;8665852;8696350;8710374;8780727;8845844;8939933;9045692;9182757;9299490;9438390;9457674;9480847;9604935;9632781;9660748;9736715;9857065;9895304;9927426",
        "class_list": "glycogene",
        "function": "FGF19-mediated ELF4 overexpression promotes colorectal cancer metastasis through transactivating FGFR4 and SRC. Publication Status: Online-Only, [RefSeq, PubMed]; FGFR1-4 RNA-Based Gene Alteration and Expression Analysis in Squamous Non-Small Cell Lung Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Oncofetal SNRPE promotes HCC tumorigenesis by regulating the FGFR4 expression through alternative splicing., [RefSeq, PubMed]; The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression. Publication Status: Online-Only, [RefSeq, PubMed]; The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer., [RefSeq, PubMed]; The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017]., [RefSeq]; Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 5,
        "mined_n_glycosites": 5,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 7,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 7,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 10,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 1801,
        "reported_interactions": 0,
        "missing_score": 8621,
        "biomarker_type": "",
        "glycan_count": 10,
        "disease_count": 14,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "G3JVM2;G3JVM5;G3JVM7;G3JVM9;O43785;Q14309;Q71TW8;Q8TDA0;Q96KE5",
        "ec_number_list": "2.7.1.153;2.7.1.137;2.7.12.2;2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;3.6.5.2;2.7.1.40;3.1.3.48;3.1.4.11;2.3.2.27;2.7.11.24;2.7.1.32;2.7.1.82;2.7.10.4;2.7.1.154;3.2.2.6;2.7.11.13;2.7.11.17;2.7.11.23",
        "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0005524 ATP binding;GO:0008201 heparin binding;GO:0017134 fibroblast growth factor binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0070857 regulation of bile acid biosynthetic process;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0016477 cell migration;GO:0018108 peptidyl-tyrosine phosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 27.6,
        "record_id": "P22455-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P35556-1",
        "uniprot_id": "FBN2_HUMAN",
        "mass": 314775.0,
        "length": 2912,
        "protein_name": "Fibrillin-2",
        "gene_name": "FBN2",
        "organism": "Human",
        "refseq_name": "fibrillin-2 isoform 1 precursor",
        "refseq_ac": "NP_001990",
        "gene_names_uniprotkb": "FBN2",
        "gene_names_refseq": "CCA; DA9; EOMD; FBN2",
        "protein_names_uniprotkb": "Fibrillin-2",
        "protein_names_refseq": "fibrillin 5; fibrillin-2 isoform 1 precursor",
        "tax_id": 9606,
        "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); scoliosis (Disease Ontology:DOID:0060249); congenital contractural arachnodactyly (Disease Ontology:DOID:0111595); Marfan syndrome (Disease Ontology:DOID:14323); macular degeneration, early-onset (MONDO:MONDO:0014501)",
        "pathway": " (hsa:2201);  (R-HSA-1474228);  (R-HSA-1566948);  (R-HSA-2129379)",
        "pathway_count": 4,
        "publication_count": 121,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10025398;10198291;10229672;10386589;10424889;10544250;10646116;10706100;10797416;10809722;10930463;10936461;10986281;11237011;11375993;11481325;11754102;11872628;11970960;12358597;12415008;12429738;12727852;12837131;12843408;1400330;14701737;14973287;15131124;15234972;15591058;15958533;16133547;1649600;16631740;16825321;16906757;1698775;1707285;1708799;17324935;17332331;17354228;17608959;18339631;18434311;1852206;18658137;19006240;19010778;19159218;19571574;19657146;19714641;20142769;20799338;21030783;21248752;21297635;21441952;21646718;21670566;21784848;21864727;22159414;23010571;23035980;23090970;23481700;23584533;23845380;24190977;24899048;25645385;25834781;26154972;26601954;26992070;27196565;29393594;29508533;29741879;32329225;32350084;32387766;32938616;33141586;33392160;34019948;34211107;34411563;34509645;34725712;35051231;35580925;37217939;37337404;38534877;38602424;38665916;38743490;6123066;7075587;7493032;7500359;7534784;7547873;8120105;8226919;8617364;8626565;9065415;9115292;9148753;9461298;9714438;9725916;9737771;9852107",
        "class_list": "",
        "function": "A comprehensive analysis of FBN2 in bladder cancer: A risk factor and the tumour microenvironment influencer., [RefSeq, PubMed]; Effect of Fibrillin-2 on Differentiation into Periodontal Ligament Stem Cell-Like Cells Derived from Human-Induced Pluripotent Stem Cells., [RefSeq, PubMed]; FBN2 pathogenic variants in congenital contractural arachnodactyly with severe cardiovascular manifestations., [RefSeq, PubMed]; Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively., [UniProtKB, UniProtKB]; Fibulin-2 is an extracellular matrix inhibitor of oligodendrocytes relevant to multiple sclerosis. Publication Status: Online-Only, [RefSeq, PubMed]; Hormone secreted by trophoblasts that promotes trophoblast invasiveness (PubMed:32329225). Has glucogenic activity: is able to increase plasma glucose levels (By similarity)., [UniProtKB, UniProtKB, PubMed]; The protein encoded by this gene is a component of connective tissue microfibrils and may be involved in elastic fiber assembly. Mutations in this gene cause congenital contractural arachnodactyly. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 7,
        "reported_o_glycosites": 27,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 7,
        "reported_o_glycosites_with_glycan": 40,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 7,
        "total_reported_o_glycosites": 41,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 7,
        "total_o_glycosites": 41,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 3,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 229,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 22,
        "disease_count": 5,
        "glyco_site_count": 54,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DU01;Q59ES6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005179 hormone activity;GO:0005201 extracellular matrix structural constituent;GO:0030023 extracellular matrix constituent conferring elasticity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0001527 microfibril",
        "go_biological_process": "GO:0042593 glucose homeostasis;GO:0006006 glucose metabolic process;GO:0048048 embryonic eye morphogenesis;GO:0030501 positive regulation of bone mineralization;GO:0045669 positive regulation of osteoblast differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 19.2,
        "record_id": "P35556-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P98173-1",
        "uniprot_id": "FAM3A_HUMAN",
        "mass": 25152.0,
        "length": 230,
        "protein_name": "Protein FAM3A",
        "gene_name": "FAM3A",
        "organism": "Human",
        "refseq_name": "protein FAM3A isoform 1 precursor",
        "refseq_ac": "NP_001164603",
        "gene_names_uniprotkb": "FAM3A; 2-19; 2.19",
        "gene_names_refseq": "2.19; DLD; DXS560S; FAM3A; XAP-7",
        "protein_names_uniprotkb": "Protein FAM3A; Cytokine-like protein 2-19",
        "protein_names_refseq": "cytokine-like protein 2-19; family with sequence similarity 3 member A; protein FAM3A isoform 1 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:60343)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "10.1038/emboj.2013.79;11237011;12160727;18212107;23481700;23562554;23584533;25502872;28834231;28904123;29314611;30573663;31611695;31910817;32350084;34357683;35051231;35132862;35251023;37474885;38875957;38937853;39182087;40307207;8248200;8733135",
        "class_list": "",
        "function": "Circulating extracellular vesicle-derived miR-1299 disrupts hepatic glucose homeostasis by targeting the STAT3/FAM3A axis in gestational diabetes mellitus. Publication Status: Online-Only, [RefSeq, PubMed]; Expressed prominently in the vascular endothelium, particularly capillaries, also in islets of Langerhans., [RefSeq, PubMed]; FAM3A mediates the phenotypic switch of human aortic smooth muscle cells stimulated with oxidised low-density lipoprotein by influencing the PI3K-AKT pathway., [RefSeq, PubMed]; FAM3A plays a key role in protecting against tubular cell pyroptosis and acute kidney injury., [RefSeq, PubMed]; In the present study, we report a putative human homologue of the antimicrobial Drosophila-derived drosomycin, designated drosomycin-like defensin (DLD), with specific antifungal activity., [RefSeq, PubMed]; In this case prenatal ultrasound images were suggestive of a serious but non-lethal skeletal dysplasia. Due to the uncertain prognosis the parents were offered Whole Exome Sequencing (WES), which identified a specific gene mutation in the FAMIIIa gene Publication Status: Online-Only, [RefSeq, PubMed]; May act as a defensin against invading fungal microorganisms., [UniProtKB]; PANX1-mediated ATP release confers FAM3A's suppression effects on hepatic gluconeogenesis and lipogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a cytokine-like protein. The expression of this gene may be regulated by peroxisome proliferator-activated receptor gamma, and the encoded protein may be involved in the regulation of glucose and lipid metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]., [RefSeq]; Upregulation of FAM3A by PPARgamma activation is correlated with increased pAkt level in liver cells, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6QRH6;B2RBI7;B4DFI8;D3DWX4;Q5HY76;Q96H51",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005125 cytokine activity;GO:0030246 carbohydrate binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region",
        "go_biological_process": "GO:1905035 negative regulation of antifungal innate immune response;GO:0007165 signal transduction;GO:0019732 antifungal humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "P98173-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P35557-1",
        "uniprot_id": "HXK4_HUMAN",
        "mass": 52191.0,
        "length": 465,
        "protein_name": "Hexokinase-4",
        "gene_name": "GCK",
        "organism": "Human",
        "refseq_name": "hexokinase-4 isoform 1",
        "refseq_ac": "NP_000153",
        "gene_names_uniprotkb": "GCK",
        "gene_names_refseq": "FGQTL3; GCK; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2; PNDM1",
        "protein_names_uniprotkb": "Hexokinase-4; 2.7.1.1; Glucokinase; HK IV; HK4; Hexokinase type IV; Hexokinase-D",
        "protein_names_refseq": "ATP:D-hexose 6-phosphotransferase; HK IV; glucokinase (hexokinase 4); hexokinase D, pancreatic isozyme; hexokinase type IV; hexokinase-4 isoform 1",
        "tax_id": 9606,
        "disease": "maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); permanent neonatal diabetes mellitus (Disease Ontology:DOID:0060639); familial hyperinsulinemic hypoglycemia 3 (Disease Ontology:DOID:0070216); maturity-onset diabetes of the young type 2 (Disease Ontology:DOID:0111100); hypertension (Disease Ontology:DOID:10763); gestational diabetes (Disease Ontology:DOID:11714); neonatal diabetes mellitus (Disease Ontology:DOID:11717); hyperinsulinemic hypoglycemia (Disease Ontology:DOID:13317); hyperinsulinism (Disease Ontology:DOID:2018); coronary artery disease (Disease Ontology:DOID:3393); glucose metabolism disease (Disease Ontology:DOID:4194); hyperglycemia (Disease Ontology:DOID:4195); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970); hypoglycemia (Disease Ontology:DOID:9993)",
        "pathway": " (hsa:2645);  (R-HSA-170822);  (R-HSA-210745);  (R-HSA-5619073);  (R-HSA-5619107);  (R-HSA-70171);  (R-HSA-9615017)",
        "pathway_count": 7,
        "publication_count": 133,
        "publication_id_list": "10102273;10217147;10358014;10456334;10480625;10588527;10601273;10694920;10714828;10913147;11106831;11237011;11371164;11372010;11506403;11514627;11779849;11780755;11916951;12239572;12616532;1278465;12802065;12941786;12965206;1303265;1349989;13538944;1354840;1360036;1397713;14627435;1464666;15016359;1502186;1511800;15277402;1545870;1570017;15710582;1612194;16511037;16783365;16840535;16965331;17082186;17573900;17804405;18322640;183598;1871135;18910716;18910717;18927083;19146401;19362831;19884385;20375417;21104275;21536589;21604084;22101819;22219026;22611063;23168256;23446454;23957911;24028821;24040102;24187134;2462567;25015100;25576301;25648650;27543614;27547294;2793178;28247534;2846554;29393594;29557506;2960695;30517626;3170585;31844290;3208766;3355497;34171305;3453121;34782236;3529090;35388005;37847371;37938771;37958824;38627865;39215018;4413246;4555506;4827367;5009693;5687724;6434534;6444721;6451249;6696436;6771269;7144574;7150652;7391027;7717389;7742312;7825568;7989588;8094163;8094164;8117307;8168652;8194664;8325892;8433729;8446612;8447317;8454109;8495817;8786021;8878425;9049484;9435328;9438414;9469993;9493266;9662401",
        "class_list": "glycogene",
        "function": "Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively) (PubMed:11916951, PubMed:15277402, PubMed:17082186, PubMed:18322640, PubMed:19146401, PubMed:25015100, PubMed:7742312, PubMed:8325892). Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant (By similarity). Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues (PubMed:11916951, PubMed:15277402, PubMed:18322640, PubMed:25015100, PubMed:8325892). Since insulin secretion parallels glucose metabolism and the low glucose affinity of GCK ensures that it can change its enzymatic activity within the physiological range of glucose concentrations, GCK acts as a glucose sensor in the pancreatic beta cell (By similarity). In pancreas, plays an important role in modulating insulin secretion (By similarity). In liver, helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (By similarity). Required to provide D-glucose 6-phosphate for the synthesis of glycogen (PubMed:8878425). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:7742312)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]; Characterizing glucokinase variant mechanisms using a multiplexed abundance assay. Publication Status: Online-Only, [RefSeq, PubMed]; G-quadruplex forming regions in GCK and TM6SF2 are targets for differential DNA methylation in metabolic disease and hepatocellular carcinoma patients. Publication Status: Online-Only, [RefSeq, PubMed]; Glucokinase Variant Proteins Are Resistant to Fasting-Induced Uridine Diphosphate Glucose-Dependent Degradation in Maturity-Onset Diabetes of the Young Type 2 Patients. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia. [provided by RefSeq, Aug 2017]., [RefSeq]; Two novel GCK mutations in Chinese patients with maturity-onset diabetes of the young., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 1008,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 17,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D2J2;A4D2J3;Q05810",
        "ec_number_list": "2.7.1.1;2.7.1.-;2.3.2.-;3.5.1.-;3.5.1.98",
        "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0019158 mannokinase activity;GO:0005524 ATP binding;GO:0005536 D-glucose binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005634 nucleus",
        "go_biological_process": "GO:0006110 regulation of glycolytic process;GO:0032024 positive regulation of insulin secretion;GO:0032869 cellular response to insulin stimulus;GO:0042593 glucose homeostasis;GO:0050796 regulation of insulin secretion",
        "synthesized_glycan_count": 0,
        "hit_score": 13.4,
        "record_id": "P35557-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15054-2",
        "uniprot_id": "KDM6B_HUMAN",
        "mass": 176632.0,
        "length": 1643,
        "protein_name": "Lysine-specific demethylase 6B",
        "gene_name": "KDM6B",
        "organism": "Human",
        "refseq_name": "lysine-specific demethylase 6B isoform 1",
        "refseq_ac": "NP_001073893",
        "gene_names_uniprotkb": "KDM6B; JMJD3; KIAA0346",
        "gene_names_refseq": "JMJD3; KDM6B; NEDCFSA; NEDSST",
        "protein_names_uniprotkb": "Lysine-specific demethylase 6B; 1.14.11.68; JmjC domain-containing protein 3; Jumonji domain-containing protein 3; Lysine demethylase 6B; [histone H3]-trimethyl-L-lysine(27) demethylase 6B",
        "protein_names_refseq": "[histone H3]-trimethyl-L-lysine(27) demethylase 6B; jmjC domain-containing protein 3; jumonji domain containing 3, histone lysine demethylase; jumonji domain-containing protein 3; lysine (K)-specific demethylase 6B; lysine-specific demethylase 6B isoform 1; lysine-specific demethylase 6B",
        "tax_id": 9606,
        "disease": "Stolerman neurodevelopmental syndrome (Disease Ontology:DOID:0081443); alcohol use disorder (Disease Ontology:DOID:1574); breast carcinoma (Disease Ontology:DOID:3459); renal cell carcinoma (Disease Ontology:DOID:4450)",
        "pathway": " (hsa:23135);  (R-HSA-2559580);  (R-HSA-3214842);  (R-HSA-9821002)",
        "pathway_count": 4,
        "publication_count": 136,
        "publication_id_list": "10347217;10722742;10772813;10871633;11564866;12134156;12189133;12193592;12421820;12435631;12808055;13130464;14507994;14532106;15287722;15563468;15620353;15866172;16186825;16337592;16362057;16436515;16603237;16603238;16732292;16732293;16738407;16826196;17193924;17210787;17254968;17255097;17310255;17320160;17320161;17320163;17332741;17344414;17351631;17363312;17395714;17713478;17765224;17825402;17851529;17875933;17923864;17947579;18003914;18365017;18628393;18793328;19451217;19451218;19462008;19502796;19528227;19727073;19843542;20023638;20084082;20129925;20208542;20457893;20622853;20622854;21532585;21986495;22020331;22325352;22336108;22420752;22615488;22683641;23186163;24714562;24715725;25505266;26154972;26811146;26992070;28218747;28262558;29351928;29437277;29557506;29563586;30779550;31124279;31844290;31848261;31998317;32157095;32357974;32387766;32488085;32897882;32983136;33141586;33298915;33912179;33968037;34171305;35051231;35314832;35580925;36010968;36241641;37917239;37974225;38019914;38218880;38245781;7535770;7588633;7816143;7859739;8001816;8078588;8259215;8319905;8622669;8622688;8626550;8741839;8774846;8846784;8974401;9030721;9162092;9195981;9529249;9564042;9628874;9768359;9824166",
        "class_list": "",
        "function": "Echinococcus granulosus cyst fluid inhibits KDM6B-mediated demethylation of trimethylated histone H3 lysine 27 and interleukin-1beta production in macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; JMJD3 demethylates di- and trimethylated lysine 27 of histone H3 in vitro and in cells., [RefSeq, PubMed]; JMJD3 was identified as a demethylase capable of removing the trimethyl group from histone H3 lysine 27 and upregulated in prostate cancer., [RefSeq, PubMed]; KDM6B drives epigenetic reprogramming associated with lymphoid stromal cell early commitment and immune properties., [RefSeq, PubMed]; MicroRNA-93-5p regulates odontogenic differentiation and dentin formation via KDM6B. Publication Status: Online-Only, [RefSeq, PubMed]; Targeting lysine demethylase 6B ameliorates ASXL1 truncation-mediated myeloid malignancies in preclinical models. Publication Status: Online-Only, [RefSeq, PubMed]; The human JmjC-domain-containing proteins UTX and JMJD3 demethylate tri-methylated Lys 27 on histone H3, [RefSeq, PubMed]; The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]., [RefSeq]; These results indicate that epigenetic derepression by JMJD3 controls mammalian epidermal differentiation., [RefSeq, PubMed]; YAP represses intestinal inflammation through epigenetic silencing of JMJD3. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 6,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 48,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9IZ40;Q96G33",
        "ec_number_list": "2.3.2.-;1.14.11.68;2.3.2.27;1.14.11.65",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0008013 beta-catenin binding;GO:0031490 chromatin DNA binding;GO:0032452 histone demethylase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0044666 MLL3/4 complex",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002437 inflammatory response to antigenic stimulus;GO:0021766 hippocampus development",
        "synthesized_glycan_count": 0,
        "hit_score": 14.3,
        "record_id": "O15054-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9ULS6-1",
        "uniprot_id": "KCNS2_HUMAN",
        "mass": 54237.0,
        "length": 477,
        "protein_name": "Delayed-rectifier potassium channel regulatory subunit KCNS2",
        "gene_name": "KCNS2",
        "organism": "Human",
        "refseq_name": "delayed-rectifier potassium channel regulatory subunit KCNS2",
        "refseq_ac": "NP_065748",
        "gene_names_uniprotkb": "KCNS2; KIAA1144",
        "gene_names_refseq": "KCNS2; KV9.2",
        "protein_names_uniprotkb": "Delayed-rectifier potassium channel regulatory subunit KCNS2; Delayed-rectifier K(+) channel alpha subunit 2; Delayed-rectifier potassium channel subunit Kv9.2; Potassium voltage-gated channel subfamily S member 2",
        "protein_names_refseq": "delayed-rectifier K(+) channel alpha subunit 2; delayed-rectifier potassium channel regulatory subunit KCNS2; delayed-rectifier potassium channel subunit Kv9.2; potassium voltage-gated channel subfamily S member 2; potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2; voltage-gated potassium channel subunit Kv9.2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3788);  (R-HSA-1296072)",
        "pathway_count": 2,
        "publication_count": 5,
        "publication_id_list": "20393197;21231794;29557506;29769701;30779550",
        "class_list": "",
        "function": "KCNS2 mutation is associated with Essential Tremor. Publication Status: Online-Only, [RefSeq, PubMed]; Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values. While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2. Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KAN1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0008076 voltage-gated potassium channel complex",
        "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q9ULS6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00139-3",
        "uniprot_id": "KIF2A_HUMAN",
        "mass": 79955.0,
        "length": 706,
        "protein_name": "Kinesin-like protein KIF2A",
        "gene_name": "KIF2A",
        "organism": "Human",
        "refseq_name": "kinesin-like protein KIF2A isoform 2",
        "refseq_ac": "NP_001091981",
        "gene_names_uniprotkb": "KIF2A; KIF2; KNS2",
        "gene_names_refseq": "CDCBM3; HK2; KIF2A; KIF2",
        "protein_names_uniprotkb": "Kinesin-like protein KIF2A; Kinesin-2; hK2",
        "protein_names_refseq": "Kinesin, heavy chain, 2; kinesin heavy chain member 2A; kinesin-2; kinesin-like protein KIF2A isoform 2; kinesin-like protein KIF2A",
        "tax_id": 9606,
        "disease": "complex cortical dysplasia with other brain malformations 3 (Disease Ontology:DOID:0090134)",
        "pathway": " (hsa:3796);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-2132295);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-5663220);  (R-HSA-6811434);  (R-HSA-68877);  (R-HSA-9648025);  (R-HSA-983189)",
        "pathway_count": 11,
        "publication_count": 329,
        "publication_id_list": "10036229;10052452;10064083;10072072;10318838;10411507;10445031;10480952;10540230;10559959;10593899;10600384;10631941;10631952;10639150;10678165;10748235;10761932;10809954;10921873;10958683;11081627;11172815;11181178;11371342;11493604;11509732;11529500;11535616;11684289;11689559;11703931;11726511;11739780;11748249;11782313;11790530;11804586;11813165;11853874;12006501;12047556;12070132;12078484;12194817;12198549;12368902;12429848;12577064;12679384;12732141;12742663;12748383;12805219;12852857;1406973;14504276;14654841;14730319;14731593;15006353;15029241;15037235;15085137;15272311;15302853;15326200;15339662;15507212;15616190;15632110;15723797;15737063;15749704;15813748;15843429;15864301;15866170;15911768;15944396;16030262;1607388;16181339;16242130;16243029;16262723;16292343;1631136;16439214;16541025;16565220;16571679;16618111;16622419;16622420;16633337;16682347;1680566;16824007;16890222;16912714;16926190;16940185;16943183;17030981;17112726;17113138;17113389;17129783;17142755;17196341;17198702;17253781;17283181;17346968;17360540;1737036;17429068;17451557;17538014;17760859;17927562;17956946;18001770;18046453;18097444;18182008;18287528;18292509;18342609;18411309;18452278;18524849;18716626;18809720;18923426;1898986;19007248;19015319;19109418;19116309;19151722;19164740;19338388;19350017;19351716;19369418;1956401;19564404;1957170;19631211;19651622;19690332;19696148;19758564;19815554;19965387;20005805;20030946;20058876;20068231;20101212;20136777;20357002;20427317;20462495;20534429;20591975;20637885;21111234;21116285;21148482;2121367;21219331;21397845;2142332;21441454;21550981;21576392;21689688;21844168;21868368;21878504;2190094;21987589;22013193;22094269;22094460;22275430;22304919;22608513;22790947;22885700;23186163;23222643;23396477;23481700;23603762;23801653;2391366;23960144;24366607;24714562;24715725;24914801;2521221;2522352;25364732;25418920;25436559;25492864;25576301;25645385;25660017;25740311;25789526;25880248;26154972;26323690;26811146;26992070;27846572;27862975;27920218;28063628;28218747;28228285;28510447;28649982;28832583;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29786170;30379171;30429286;30484775;30785839;3130248;3134048;31409757;31844290;32157095;32265295;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33717175;33797694;33912179;33936100;33968037;34019948;34171305;34211107;34229054;34260926;34932366;35051231;35313389;35580925;36010968;37217939;37615667;38117947;40914422;7481823;7528108;7539720;7592972;7650016;7667286;7822426;7844144;7929562;8001155;8046351;8128252;8132710;8134367;8145819;8148318;8221884;8253837;8313912;8397411;8415765;8505331;8548803;8599929;8602245;8620540;8642258;8687433;8849454;8909537;8939989;8947036;9075930;9114004;9177194;9177777;9202021;9244307;9288971;9311912;9312039;9405360;9497313;9539769;9545226;9606180;9649308;9649503;9751720;9892021;9990005",
        "class_list": "",
        "function": "Clinical significance of kinesin family member 2A as a facilitating biomarker of disease surveillance and prognostication in cervical cancer patients., [RefSeq, PubMed]; Kif2a has a role in bipolar spindle assembly along with MCAK, [RefSeq, PubMed]; Kinesin family member 2A links with advanced tumor stage, reduced chemosensitivity and worse prognosis in gastric cancer., [RefSeq, PubMed]; NuSAP regulates microtubule flux and Kif2A localization to ensure accurate chromosome congression., [RefSeq, PubMed]; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Spindles in human mitotic cells depleted of the kinesin-13 proteins Kif2a and MCAK lack detectable flux and that such cells frequently fail to segregate all chromosomes appropriately at anaphase., [RefSeq, PubMed]; The minus-end depolymerase KIF2A drives flux-like treadmilling of gammaTuRC-uncapped microtubules., [RefSeq, PubMed]; The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5YM42;A5YM54;B4DY54;D3DW97;E9PB70;Q7Z5I3;Q8N5Q7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity;GO:0003774 cytoskeletal motor activity",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle",
        "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0030334 regulation of cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 33.2,
        "record_id": "O00139-3",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96QK8-1",
        "uniprot_id": "SIM14_HUMAN",
        "mass": 10710.0,
        "length": 99,
        "protein_name": "Small integral membrane protein 14",
        "gene_name": "SMIM14",
        "organism": "Human",
        "refseq_name": "small integral membrane protein 14",
        "refseq_ac": "NP_001304825",
        "gene_names_uniprotkb": "SMIM14; C4orf34",
        "gene_names_refseq": "C4orf34; SMIM14",
        "protein_names_uniprotkb": "Small integral membrane protein 14",
        "protein_names_refseq": "small integral membrane protein 14",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:201895)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "11237011;24499674;24715725;27846572;28832583;29242379;29557506;29632711;29789417;30429286;31217245;31844290;31848261;32502341;32897882;32983136;33141586;33298915;33912179;33936100;34211107",
        "class_list": "",
        "function": "HC4orf34 is an endoplasmic reticulum-resident type I transmembrane protein., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q96QK8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N0X7-1",
        "uniprot_id": "SPART_HUMAN",
        "mass": 72833.0,
        "length": 666,
        "protein_name": "Spartin",
        "gene_name": "SPART",
        "organism": "Human",
        "refseq_name": "spartin",
        "refseq_ac": "NP_001135766",
        "gene_names_uniprotkb": "SPART; KIAA0610; SPG20; TAHCCP1",
        "gene_names_refseq": "SPART; SPG20; TAHCCP1",
        "protein_names_uniprotkb": "Spartin; Spastic paraplegia 20 protein; Trans-activated by hepatitis C virus core protein 1",
        "protein_names_refseq": "spartin; spastic paraplegia 20 (Troyer syndrome); trans-activated by hepatitis C virus core protein 1",
        "tax_id": 9606,
        "disease": "Troyer syndrome (Disease Ontology:DOID:0050886)",
        "pathway": " (hsa:23111)",
        "pathway_count": 1,
        "publication_count": 83,
        "publication_id_list": "11466336;12134148;12676568;18669648;19580544;20068231;20719964;23186163;23481700;24366607;24714562;25502872;25645385;25880248;26375851;26992070;27539578;27543614;27846572;27862975;27920218;28228285;28514659;28657654;28832583;28875386;28904123;29237092;29242379;29331515;29508533;29557506;29786170;30059200;30315122;30379171;30429286;30524438;30620550;30833945;31154438;31217245;31222486;31492838;31844290;31848261;32119511;32157095;32387766;32488085;32502341;32897882;32938616;32938750;32983136;33141586;33392160;33592498;33717175;33936100;33968037;34171305;34211107;34357683;34561969;34725712;35051231;35154160;35254053;35318648;35389570;35513511;35580925;36010968;36241641;36284347;37443287;37541260;37938771;38190532;38503285;38665916;39531497",
        "class_list": "",
        "function": "Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons (PubMed:37443287). Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy (PubMed:37443287). Lipid transfer protein required for lipid droplet degradation, including by lipophagy (PubMed:38190532). Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown (PubMed:38190532). May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964)., [UniProtKB, PubMed, PubMed, PubMed]; Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH., [RefSeq, PubMed]; SPG20 is mutated in Troyer syndrome, an hereditary spastic paraplegia.We report mapping of the TRS locus to chromosome 13q12.3 and identify a frameshift mutation in SPG20, encoding spartin, [RefSeq, PubMed]; Spastic Paraplegia 20 and Serine/Threonine Protein Kinase 31 Expression for the Detection of Colorectal Cancer., [RefSeq, PubMed]; This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq, Nov 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60349;Q86Y67;Q9H1T2;Q9H1T3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0008289 lipid binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006869 lipid transport;GO:0051301 cell division;GO:0016042 lipid catabolic process;GO:0051881 regulation of mitochondrial membrane potential;GO:0030514 negative regulation of BMP signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 8.6,
        "record_id": "Q8N0X7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z7N9-1",
        "uniprot_id": "T179B_HUMAN",
        "mass": 23550.0,
        "length": 219,
        "protein_name": "Transmembrane protein 179B",
        "gene_name": "TMEM179B",
        "organism": "Human",
        "refseq_name": "transmembrane protein 179B isoform 1 precursor",
        "refseq_ac": "NP_955369",
        "gene_names_uniprotkb": "TMEM179B",
        "gene_names_refseq": "TMEM179B",
        "protein_names_uniprotkb": "Transmembrane protein 179B",
        "protein_names_refseq": "transmembrane protein 179B isoform 1 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:374395);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 30,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;19690332;23186163;23650620;24190977;25418920;25576301;25892735;26992070;27920218;28218747;28228285;28832583;28834231;29242379;29437277;30484775;30524438;31844290;32157095;32938616;32983136;33298915;33968037;34019948;35051231;35580925;36241641;8692836",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0030667 secretory granule membrane;GO:0101003 ficolin-1-rich granule membrane;GO:0035577 azurophil granule membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "Q7Z7N9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TBG9-1",
        "uniprot_id": "SYNPR_HUMAN",
        "mass": 29166.0,
        "length": 265,
        "protein_name": "Synaptoporin",
        "gene_name": "SYNPR",
        "organism": "Human",
        "refseq_name": "synaptoporin isoform 1",
        "refseq_ac": "NP_001123475",
        "gene_names_uniprotkb": "SYNPR",
        "gene_names_refseq": "SPO; SYNPR",
        "protein_names_uniprotkb": "Synaptoporin",
        "protein_names_refseq": "synaptoporin isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:132204)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11237011;12740598;12974474;25138779;29557506;37074911",
        "class_list": "",
        "function": "Cloning and characterization of the human cDNA that encodes the human homologue of synaptoporin, [RefSeq, PubMed]; Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity)., [UniProtKB]; Results from genome-wide association studies identify synaptoporin gene as one of the three susceptibility loci candidate for congenital left-sided lesions., [RefSeq, PubMed]; Tyrosine nitration of synaptophysin is related to Amyloid beta induced impairment of acetylcholine release., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 9577,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R675;G5E9W4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0043005 neuron projection;GO:0030672 synaptic vesicle membrane;GO:0016020 membrane;GO:0008021 synaptic vesicle",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q8TBG9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13813-1",
        "uniprot_id": "SPTN1_HUMAN",
        "mass": 284539.0,
        "length": 2472,
        "protein_name": "Spectrin alpha chain, non-erythrocytic 1",
        "gene_name": "SPTAN1",
        "organism": "Human",
        "refseq_name": "spectrin alpha chain, non-erythrocytic 1 isoform 1",
        "refseq_ac": "NP_001123910",
        "gene_names_uniprotkb": "SPTAN1; NEAS; SPTA2",
        "gene_names_refseq": "DEE5; DEVEP; EIEE5; HMN11; HMND11; NEAS; SPG91; SPTA2; SPTAN1",
        "protein_names_uniprotkb": "Spectrin alpha chain, non-erythrocytic 1; Alpha-II spectrin; Fodrin alpha chain; Spectrin, non-erythroid alpha subunit",
        "protein_names_refseq": "alpha-II spectrin; alpha-fodrin; epididymis secretory sperm binding protein; fodrin alpha chain; spectrin alpha chain, non-erythrocytic 1 isoform 1; spectrin alpha chain, non-erythrocytic 1; spectrin, non-erythroid alpha chain; spectrin, non-erythroid alpha subunit",
        "tax_id": 9606,
        "disease": "hereditary spastic paraplegia 91 (Disease Ontology:DOID:0070643); developmental and epileptic encephalopathy 5 (Disease Ontology:DOID:0080438); autosomal dominant distal hereditary motor neuronopathy 11 (Disease Ontology:DOID:0081400); developmental delay with or without epilepsy (MONDO:MONDO:0957815)",
        "pathway": " (hsa:6709);  (R-HSA-264870);  (R-HSA-373753);  (R-HSA-375165);  (R-HSA-445095);  (R-HSA-5673001);  (R-HSA-6798695);  (R-HSA-6807878);  (R-HSA-9013420);  (R-HSA-9013424);  (R-HSA-9662360);  (R-HSA-9662361)",
        "pathway_count": 12,
        "publication_count": 365,
        "publication_id_list": "10.1101/2023.09.13.557529;10025409;10052452;10318838;10393930;10445031;10469173;10508167;10541305;10559959;10564664;10611248;10625438;10679020;10761932;10821263;10823823;10869344;10891503;10899937;10903204;10921873;11027663;11035033;11090077;11136978;11163272;11172815;11222639;11237011;11285137;11306556;11313946;11340081;11423904;11459829;11461920;11546808;11562357;11689006;11689559;11702783;11703931;11726511;11733557;11748249;11971983;12032311;12047556;12070132;12094235;12121613;12388752;12446661;12634853;12660326;12668668;12700044;12846735;12865409;14506247;14521508;14570703;14633607;14654841;14707138;14742712;15037235;15302935;15328537;15331416;15350535;15356145;1545823;15545998;15546878;15556869;15579503;15616190;15632110;15634346;15728195;15813748;15843475;15878873;15994232;16030262;1631136;16525419;16543952;16597699;16627759;16630808;16633337;16684964;16723730;1680566;16904324;16912714;16926190;16940185;16945920;16959974;17081983;1716764;17223356;17253781;17274799;17355222;17360540;17429068;17451557;17504809;17760859;17893108;17923684;17927562;17956946;17998941;18033240;18048348;18083107;18086915;18182008;18283113;18452278;18491316;18524849;18621045;18669648;18775330;18809720;1898771;1898986;18991276;19015319;19064640;19109418;19164740;19279408;19296914;19413330;19443634;19531498;1957170;19608861;19631211;19651622;19664994;19664995;19690332;19758564;19920141;20058876;20068231;20166139;20233749;20357002;20427317;20478380;20493457;20547754;20637885;21102635;21219331;21372320;21406692;21508312;21565175;21689688;21779497;21779505;21844168;21993244;22013193;22094269;22121020;22299025;22304919;22339630;22429196;22569528;22589270;22656320;22750304;2307671;23103841;23186163;23303910;23443682;23481700;23575685;23650620;23783831;23839779;24119662;24275569;24366607;24714562;24715725;24806965;24897931;24937142;25219551;25418920;25436559;25492864;25502872;25505266;25576301;25645385;25781681;25880248;25892735;26085527;26154972;26375851;26598620;26728094;26811146;26853435;26929215;26992070;27543614;27600516;27846572;27862975;27864847;27920218;28063628;2809592;28218747;28228285;28514659;28778966;28832583;28834231;28855257;28904123;29050398;29242379;29317506;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30315122;30379171;3038643;30410026;30429286;30524438;30620550;31020640;31135801;31332438;31844290;31871319;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32737221;32897882;32938616;32983136;33043033;33123756;33214551;33298915;33537174;33578420;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34067543;34078123;34087483;34171305;34211107;34405274;34509645;34561969;34725712;34932366;35008409;35051231;35083852;35138101;35150594;35154160;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36331550;36581221;3691949;37938771;38665916;40596516;6148751;7489707;7607240;7691276;7809086;7935463;7972015;7997267;8001155;8052307;8128252;8132710;8221884;8253837;8394845;8493579;8505331;8620540;8636227;8665852;8692836;8710374;8939933;8991093;8993318;9114004;9150144;9177194;9244307;9288971;9323141;9323209;9380700;9382863;9405360;9490716;9604935;9624143;9671725;9687510;9751720;9778532;9927426;9930654;9990005",
        "class_list": "",
        "function": "Alpha-Fodrin in Cytoskeletal Organization and the Activity of Certain Key Microtubule Kinesins. Publication Status: Online-Only, [RefSeq, PubMed]; De Novo and Dominantly Inherited SPTAN1 Mutations Cause Spastic Paraplegia and Cerebellar Ataxia., [RefSeq, PubMed]; Expanding SPTAN1 monoallelic variant associated disorders: From epileptic encephalopathy to pure spastic paraplegia and ataxia., [RefSeq, PubMed]; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 36,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 38,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 4,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q13186;Q15324;Q16606;Q59EF1;Q5VXV5;Q5VXV6;Q7Z6M5;Q9P0V0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0005516 calmodulin binding;GO:0051015 actin filament binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030054 cell junction",
        "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0051693 actin filament capping",
        "synthesized_glycan_count": 0,
        "hit_score": 37.2,
        "record_id": "Q13813-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BRL7-1",
        "uniprot_id": "SC22C_HUMAN",
        "mass": 34269.0,
        "length": 303,
        "protein_name": "Vesicle-trafficking protein SEC22c",
        "gene_name": "SEC22C",
        "organism": "Human",
        "refseq_name": "vesicle-trafficking protein SEC22c isoform b",
        "refseq_ac": "NP_001188501",
        "gene_names_uniprotkb": "SEC22C; PRO784; SEC22L3",
        "gene_names_refseq": "SEC22C; SEC22L3",
        "protein_names_uniprotkb": "Vesicle-trafficking protein SEC22c; SEC22 vesicle-trafficking protein homolog C; SEC22 vesicle-trafficking protein-like 3",
        "protein_names_refseq": "SEC22 vesicle trafficking protein homolog C; SEC22 vesicle trafficking protein-like 3; SEC22 vesicle trafficking protein-like protein C; secretion deficient 22C; vesicle-trafficking protein SEC22c isoform b; vesicle-trafficking protein SEC22c",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9117);  (R-HSA-204005)",
        "pathway_count": 2,
        "publication_count": 89,
        "publication_id_list": "10445031;10559959;10679020;10747087;10788476;10825291;10903204;10982397;11035026;11237011;11285137;11306556;11927603;12070132;12235121;12975309;15037235;16303754;16495487;16624868;16912714;17005010;17038314;17192411;17287728;17316621;17562788;17684057;18843296;19164740;19638414;19656848;20545907;20679433;20966969;21478858;21532587;21689688;22013193;22157747;22675024;23378591;23479643;23481700;23698585;23864707;24119662;24917561;25202031;25406594;25492864;25586378;25619252;25645385;26992070;27846572;27920218;28414125;28904123;29493099;30315122;31844290;32157095;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33717175;33912179;33968037;34171305;34509645;35051231;35561310;36241641;8221884;8620540;8663406;9094723;9150144;9177194;9307973;9501016;9647643",
        "class_list": "",
        "function": "May be involved in vesicle transport between the ER and the Golgi complex., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results indicate that the splicing-dependent changes in the number of TMDs allow Sec22c to regulate the subcellular localization in cooperation with ARF4, implying that Sec22c will function at the Golgi as well as the ER., [RefSeq, PubMed]; This gene encodes a member of the SEC22 family of vesicle trafficking proteins. The encoded protein is localized to the endoplasmic reticulum and may play a role in the early stages of ER-Golgi protein trafficking. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O95152;Q68CX3;Q6UW18",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport",
        "synthesized_glycan_count": 0,
        "hit_score": 9.0,
        "record_id": "Q9BRL7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WWG1-1",
        "uniprot_id": "NRG4_HUMAN",
        "mass": 12722.0,
        "length": 115,
        "protein_name": "Pro-neuregulin-4, membrane-bound isoform",
        "gene_name": "NRG4",
        "organism": "Human",
        "refseq_name": "pro-neuregulin-4, membrane-bound isoform",
        "refseq_ac": "NP_612640",
        "gene_names_uniprotkb": "NRG4",
        "gene_names_refseq": "HRG4; NRG4",
        "protein_names_uniprotkb": "Pro-neuregulin-4, membrane-bound isoform; Pro-NRG4",
        "protein_names_refseq": "heregulin 4; pro-NRG4; pro-neuregulin-4, membrane-bound isoform",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:145957);  (R-HSA-1227986);  (R-HSA-1236394);  (R-HSA-1250196);  (R-HSA-1250342);  (R-HSA-1250347);  (R-HSA-1251985);  (R-HSA-1257604);  (R-HSA-1963640);  (R-HSA-1963642);  (R-HSA-2219530);  (R-HSA-5673001);  (R-HSA-6785631);  (R-HSA-6811558);  (R-HSA-8847993);  (R-HSA-8863795);  (R-HSA-9664565);  (R-HSA-9665686)",
        "pathway_count": 18,
        "publication_count": 203,
        "publication_id_list": "10.1101/2023.09.13.557529;10191262;10508167;10722704;10867024;10869344;10878805;11027663;11071886;11090077;11136978;11147812;11237011;11313946;11432829;11546808;11679632;11702783;11803464;12032311;12052829;12094235;12121613;12167717;12239347;12651161;12767043;12807903;1325671;14506247;14660651;14707138;15023535;15059917;15156151;15356145;1545823;15534001;15546878;15568014;15583696;15643424;15718470;15834429;16061658;16339315;16456541;16627759;16647110;16684964;16843263;1688559;16912174;16978839;17018285;17030621;1706616;1716764;17200115;17311002;17545517;17626883;17652160;17684490;17962208;17998941;18039657;18045866;18079394;18317450;18413839;18594509;18606717;18653779;18719096;18721752;18754654;18755892;18775330;18829560;18925875;18955552;1898771;19047365;19185485;19279408;19411071;19576174;19596786;19644473;1973074;19805105;19920141;19933325;19962665;2022652;20231295;20338997;20478380;20522708;20713702;20937854;21102635;21188471;21317208;21368164;21372320;21376233;21478295;21668414;21779497;21779505;21827948;21840311;21976531;21984976;21993244;22046346;22120714;22188813;22569528;22588880;22589270;22750304;22802530;23103841;23220880;23230144;23303910;23443682;23575685;23843458;23846654;23948973;24308844;24829397;24897931;24937142;24971884;25081058;25219551;2543678;25781681;25853726;25994018;26085527;26375550;26545934;28274957;28778966;29967253;30301790;30314968;30449325;30854046;31135801;33392160;33912179;34159710;34261740;35603674;37369570;38465779;6148751;7478576;7541030;7542744;7556068;7565730;7637810;7744773;7809086;7929212;7929214;7935463;7970720;7972015;8026468;8036006;8052307;8101647;8394845;8493579;8530511;8617201;8617750;8622888;8645157;8657148;8665852;8665853;8710374;8939933;9135143;9168115;9232641;9275162;9461599;9556621;9604935;9736715;9895304;9927426",
        "class_list": "",
        "function": "Describes a novel splice variant of the NRG4 gene, NRG4A2, which encodes a C-terminal region containing a predicted type I PDZ-binding peptide, [RefSeq, PubMed]; Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mutations of NRG4 Contribute to the Pathogenesis of Nonalcoholic Fatty Liver Disease and Related Metabolic Disorders., [RefSeq, PubMed]; NGR4 and ERBB4 as Promising Diagnostic and Therapeutic Targets for Metabolic Disorders. Review article, [RefSeq, PubMed]; NRG4 overexpression is associated with advanced-stage prostate cancer, [RefSeq, PubMed]; NRG4 was positive in almost all breast cancers studied., [RefSeq, PubMed]; Neuregulin 4 (NRG4) - the hormone with clinical significance in gestational diabetes mellitus., [RefSeq, PubMed]; Neuregulin 4 (Nrg4) cooperates with melatonin to regulate the PRL expression via ErbB4/Erk signaling pathway as a potential prolactin (PRL) regulator., [RefSeq, PubMed]; Neuregulin-4 expression is downregulated during urinary bladder cancer progression, [RefSeq, PubMed]; Serum neuregulin 4 (NRG-4) level and non-alcoholic fatty liver disease (NAFLD): A case-control study., [RefSeq, PubMed]; The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NIE8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008083 growth factor activity;GO:0048018 receptor ligand activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0038138 ERBB4-ERBB4 signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 20.6,
        "record_id": "Q8WWG1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95486-1",
        "uniprot_id": "SC24A_HUMAN",
        "mass": 119749.0,
        "length": 1093,
        "protein_name": "Protein transport protein Sec24A",
        "gene_name": "SEC24A",
        "organism": "Human",
        "refseq_name": "protein transport protein Sec24A isoform 2",
        "refseq_ac": "NP_001239160",
        "gene_names_uniprotkb": "SEC24A",
        "gene_names_refseq": "SEC24A",
        "protein_names_uniprotkb": "Protein transport protein Sec24A; SEC24-related protein A",
        "protein_names_refseq": "SEC24 family, member A; SEC24 homolog A, COPII coat complex component; SEC24 related gene family, member A; SEC24-related protein A; protein transport protein Sec24A isoform 2; protein transport protein Sec24A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10802);  (R-HSA-1655829);  (R-HSA-204005);  (R-HSA-2132295);  (R-HSA-5694530);  (R-HSA-9705671);  (R-HSA-983170)",
        "pathway_count": 7,
        "publication_count": 349,
        "publication_id_list": "10036229;10064069;10064083;10072072;10075675;10397761;10428864;10445031;10480952;10540230;10559958;10559959;10593899;10600378;10631941;10631952;10639150;10644685;10652252;10679020;10747087;10748235;10777614;10788476;10805775;10809954;10825291;10903204;10982397;11035026;11160214;11163199;11237011;11283257;11285137;11306556;11514579;11529500;11684289;11790530;11813165;11853874;11927603;12019269;12070132;12078484;12198549;12235121;12237308;12436109;12436110;12645939;12692549;12742663;12748383;12759408;14645851;14681859;14718384;14731593;15037235;15208624;15286279;15550381;15749704;15911768;15927284;16129679;16181339;16242130;16303754;16465444;16473882;16495487;16618111;16624868;16824007;16912714;17005010;17010120;17038314;17056546;17088086;17142755;17192411;17283181;17287728;17316621;17322306;17449569;17499046;17562788;17607000;17656363;17684057;18025080;18046453;18283111;18287528;18292509;18843296;19119025;19164740;19193869;19261456;19265014;19269366;19342655;19361863;19426129;1956401;19564404;19566487;19575639;19638414;19656848;19851281;2038058;20427317;20477988;20533886;20545907;20605430;20679433;20805473;20966969;21050182;21116285;2121367;21441454;21478858;21525241;21532587;21689688;21878990;2190094;22013193;22157747;22424782;22544926;22675024;22941947;23301498;23378591;23479643;23698585;23852824;23864707;2391366;24119662;2450918;24714562;24715725;24917561;25202031;25406594;25418920;25492864;25576301;25586378;25619252;25619253;25645385;25880248;25892735;26154972;26811146;26992070;27846572;27920218;28218747;28228285;28467828;28514659;28832583;28904123;29242379;29351928;29393594;29437277;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30315122;30397120;30410026;30484775;30779550;30833945;31154438;31530632;31844290;31850239;31875875;31937595;31998317;32157095;32161166;32265295;32350084;32353859;32357974;32387766;32428392;32488085;32502341;32574038;32589897;32690950;32726803;32728199;32897882;32938616;32938750;32953130;32979938;32983136;33024073;33043033;33060197;33097660;33110251;33141586;33214551;33298915;33349665;33360543;33372174;33372854;33396605;33440148;33479219;33495715;33514628;33567255;33592498;33717175;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33912179;33936100;33963333;33968037;33981976;33989516;33990585;34019948;34021074;34054808;34084167;34110168;34166398;34171305;34185709;34239064;34290717;34325283;34341353;34357683;34375313;34400613;34439781;34452305;34471099;34502139;34509645;34561969;34597346;34846842;35051231;35102342;35132862;35138101;35154160;35254053;35318648;35513511;35561310;35580925;35643212;35901214;36010968;36240223;36241641;36284347;36581221;37051252;37217939;38665916;38838015;39302247;39531497;39534244;40914422;41350704;7481823;7592972;7642652;7650016;7667286;7876241;8046351;8134367;8145819;8148318;8156598;8221884;8313912;8342042;8397411;8415765;8620540;8642258;8663406;8674110;8687433;8849454;8909537;8939989;8947036;9075930;9094723;9150144;9177194;9202021;9307973;9311912;9312039;9395526;9472029;9488713;9497313;9539769;9545226;9605141;9606180;9634703;9647643;9659902",
        "class_list": "",
        "function": "CircRNA circ_SEC24A upregulates DNMT3A expression by sponging miR-26b-5p to aggravate osteoarthritis progression., [RefSeq, PubMed]; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296)., [UniProtKB, PubMed, PubMed, PubMed]; Selective inhibition of protein secretion by abrogating receptor-coat interactions during ER export., [RefSeq, PubMed]; The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 13,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 13,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 13,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 42,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 14,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MVW3;Q8WUV2;Q96GP7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000149 SNARE binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0012507 ER to Golgi transport vesicle membrane;GO:0070971 endoplasmic reticulum exit site",
        "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport;GO:0070863 positive regulation of protein exit from endoplasmic reticulum",
        "synthesized_glycan_count": 0,
        "hit_score": 36.4,
        "record_id": "O95486-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14151-1",
        "uniprot_id": "SAFB2_HUMAN",
        "mass": 107473.0,
        "length": 953,
        "protein_name": "Scaffold attachment factor B2",
        "gene_name": "SAFB2",
        "organism": "Human",
        "refseq_name": "scaffold attachment factor B2",
        "refseq_ac": "NP_055464",
        "gene_names_uniprotkb": "SAFB2; KIAA0138",
        "gene_names_refseq": "SAFB2",
        "protein_names_uniprotkb": "Scaffold attachment factor B2; SAF-B2",
        "protein_names_refseq": "scaffold attachment factor B2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9667)",
        "pathway_count": 1,
        "publication_count": 84,
        "publication_id_list": "11237011;12660241;14587024;15302935;15345747;17081983;17287340;17924679;18452278;18491316;18669648;19077293;19137425;19367720;19413330;19415658;19608861;19651622;19664995;19674106;19901029;20068231;20166139;21406692;21527249;22028470;22223895;22566185;23186163;23301498;24129315;24275569;24715725;25114211;25218447;25755297;25772364;26273616;26992070;27846572;27862975;27920218;28514659;28832583;28834231;28855257;28904123;29242379;29393594;29493099;29557506;29632046;29632711;30315122;30379171;30429286;31154438;31844290;32157095;32265295;32357974;32387766;32488085;32502341;32502422;32938616;32983136;33141586;33298915;33592498;33691108;33912179;33936100;33968037;34019948;34211107;34509645;35051231;35083852;35251023;35494241;35580925;36652182;40596516",
        "class_list": "",
        "function": "Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation., [UniProtKB]; REVIEW: possibility that SAFB1 and SAFB2 are novel breast tumor suppressor genes, and how they might function in this role, are discussed Review article, [RefSeq, PubMed]; Results indicate that SAFB1 and SAFB2 are crucial repressors for ERalpha dynamics in association with the nuclear matrix and that their synergistic regulation of ERalpha mobility is sufficient for inhibiting ERalpha function., [RefSeq, PubMed]; SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts., [RefSeq, PubMed]; SAFB2 Inhibits the Progression of Breast Cancer by Suppressing the Wnt/beta-Catenin Signaling Pathway via NFAT5., [RefSeq, PubMed]; SAFB2 is not likely to be causative of the hereditary breast cancer syndrome in west Swedish breast cancer families Publication Status: Online-Only, [RefSeq, PubMed]; Single depletion of either SAFB1 or SAFB2 leads to an increase in expression of the other SAFB protein., [RefSeq, PubMed]; Study confirms the primary role of SAFB1/SAFB2 as corepressors and also uncovers a previously unknown role for SAFB1 in the regulation of immune genes and in estrogen-mediated repression of genes., [RefSeq, PubMed]; The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2., [RefSeq, PubMed]; The protein encoded by this gene, along with its paralog (scaffold attachment factor B1), is a repressor of estrogen receptor alpha. The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation, apoptosis, differentiation, the stress response, and regulation of immune genes. [provided by RefSeq, May 2016]., [RefSeq]; This study shows that low SAFB protein levels predict poor prognosis of breast cancer patients, suggesting critical functions of SAFB1 and SAFB2 in breast cancer cells., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 31,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DKG3;Q8TB13",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0070062 extracellular exosome;GO:0016604 nuclear body",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0060765 regulation of androgen receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 8.7,
        "record_id": "Q14151-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UBK9-1",
        "uniprot_id": "UXT_HUMAN",
        "mass": 18246.0,
        "length": 157,
        "protein_name": "Protein UXT",
        "gene_name": "UXT",
        "organism": "Human",
        "refseq_name": "protein UXT isoform 2",
        "refseq_ac": "NP_004173",
        "gene_names_uniprotkb": "UXT; HSPC024",
        "gene_names_refseq": "ART-27; SKP2; STAP1; UXT",
        "protein_names_uniprotkb": "Protein UXT; ART-27; Androgen receptor trapped clone 27 protein; Ubiquitously expressed transcript protein",
        "protein_names_refseq": "SKP2-associated alpha PFD 1; androgen receptor trapped clone 27 protein; protein UXT isoform 2; protein UXT; ubiquitously expressed transcript protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8409);  (R-HSA-8953750)",
        "pathway_count": 2,
        "publication_count": 102,
        "publication_id_list": "10087202;11171983;11237011;11827465;11854421;12004135;12909625;15014447;15536069;16221885;17001316;17554592;17600109;17620405;17635584;18562691;21307340;21596310;21730289;22544926;22933289;23481700;23954429;24627085;24715725;25418920;25576301;25645385;26154972;26375851;26992070;27600516;27846572;27862975;27920218;28106301;28228285;28514659;28832583;28904123;29242379;29331515;29393594;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30315122;30429286;30524438;30779550;31092671;31154438;31217245;31530632;31738558;31844290;31848261;31937595;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33010352;33141586;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;34087483;34171305;34211107;34357683;34433824;34509645;34767964;35051231;35217267;35318648;35561310;35580925;36010968;36215666;37468105;37938771;7623816;9501179;9689056;9704927",
        "class_list": "",
        "function": "HOXD9 transcriptionally induced UXT facilitate breast cancer progression via epigenetic modification of RND3., [RefSeq, PubMed]; Involved in gene transcription regulation (PubMed:21730289, PubMed:28106301). Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription (PubMed:11854421, PubMed:21730289). Together with URI1, associates with chromatin to the NKX3-1 promoter region (PubMed:21730289). Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm (PubMed:28106301). May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity (PubMed:17620405, PubMed:21307340). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:17554592). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MYB regulates the SUMO protease SENP1 and its novel interaction partner UXT, modulating MYB target genes and the SUMO landscape., [RefSeq, PubMed]; Plays a role in protecting cells against TNF-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP., [UniProtKB, PubMed]; Prefoldin and prefoldin-like complex subunits as predictive biomarkers for hepatocellular carcinoma immunotherapy., [RefSeq, PubMed]; The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]., [RefSeq]; UXT was identified in a screen for proteins that interact with the Androgen Receptor N-terminal activation domain.  We termed the protein Androgen Receptor Trapped clone 27 (ART-27).  ART-27 appears to function as a transcriptional coactivator protein., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A0C4DFR8;B2R561;Q5JZG3;Q9Y6E5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0008017 microtubule binding;GO:0003714 transcription corepressor activity;GO:0048487 beta-tubulin binding",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome",
        "go_biological_process": "GO:0047497 mitochondrion transport along microtubule;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 10.3,
        "record_id": "Q9UBK9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NX94-1",
        "uniprot_id": "WBP1L_HUMAN",
        "mass": 37828.0,
        "length": 342,
        "protein_name": "WW domain binding protein 1-like",
        "gene_name": "WBP1L",
        "organism": "Human",
        "refseq_name": "WW domain binding protein 1-like isoform 1 precursor",
        "refseq_ac": "NP_001077382",
        "gene_names_uniprotkb": "WBP1L; C10orf26; OPA1L",
        "gene_names_refseq": "C10orf26; OPA1L; OPAL1; WBP1L",
        "protein_names_uniprotkb": "WW domain binding protein 1-like; Outcome predictor in acute leukemia 1",
        "protein_names_refseq": "WW domain binding protein 1-like isoform 1 precursor; outcome predictor in acute leukemia 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54838)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "11237011;16385451;16709928;23186163;25502872;28467828;29557506;30422892;31840934;33592498;33912179;34171305;34357683;35154160;35251023;36241641",
        "class_list": "",
        "function": "Evaluation of the relationships of the WBP1L gene with schizophrenia and the general psychopathology scale based on a case-control study., [RefSeq, PubMed]; OPAL1 expression may not be an independent prognostic feature in childhood ALL, and its previously reported prognostic impact appears to be treatment dependent., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; WBP1L SNP rs176185 may be associated with hypertension in the Chinese Han population., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KPF4;B7Z6S7;D3DR90;Q1EG70;Q2HIY7;Q5F2G6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "GO:0038160 CXCL12-activated CXCR4 signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q9NX94-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UFB7-1",
        "uniprot_id": "ZBT47_HUMAN",
        "mass": 82760.0,
        "length": 747,
        "protein_name": "Zinc finger and BTB domain-containing protein 47",
        "gene_name": "ZBTB47",
        "organism": "Human",
        "refseq_name": "zinc finger and BTB domain-containing protein 47 isoform 2",
        "refseq_ac": "NP_660149",
        "gene_names_uniprotkb": "ZBTB47; KIAA1190; ZNF651",
        "gene_names_refseq": "ZBTB47; ZNF651",
        "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 47; Zinc finger protein 651",
        "protein_names_refseq": "zinc finger and BTB domain-containing protein 47 isoform 2; zinc finger and BTB domain-containing protein 47; zinc finger protein 651",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:92999)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11237011;20068231;20116376;25576301;28228285;29393594;30192525;30429286;31154438;31844290;32157095;32502341;32938616;34171305;35580925;36010968;37217939;37743782",
        "class_list": "",
        "function": "Data show that ZNF651 is a ZNF652 paralogue that shares a common DNA binding sequence with ZNF652 and represses target gene expression through the formation of a CBFA2T3-ZNF651 corepressor complex., [RefSeq, PubMed]; De novo missense variants in ZBTB47 are associated with developmental delays, hypotonia, seizures, gait abnormalities, and variable movement abnormalities. Erratum:[Am J Med Genet A. 2024 Jun;194(6):e63558. doi: 10.1002/ajmg.a.63558. PMID: 38327012], [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "H7BXD3;Q6ZSY6;Q8WTY8;Q9ULN0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q9UFB7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q06547-1",
        "uniprot_id": "GABP1_HUMAN",
        "mass": 42483.0,
        "length": 395,
        "protein_name": "GA-binding protein subunit beta-1",
        "gene_name": "GABPB1",
        "organism": "Human",
        "refseq_name": "GA-binding protein subunit beta-1 isoform beta 1",
        "refseq_ac": "NP_001307839",
        "gene_names_uniprotkb": "GABPB1; E4TF1B; GABPB2; GABPB",
        "gene_names_refseq": "BABPB2; E4TF1-47; E4TF1-53; E4TF1B; E4TF1; GABPB-1; GABPB1; GABPB2; GABPB; NRF2B1; NRF2B2",
        "protein_names_uniprotkb": "GA-binding protein subunit beta-1; GABP subunit beta-1; GABP subunit beta-2; GABPB-1; GABPB-2; Nuclear respiratory factor 2; Transcription factor E4TF1-47; Transcription factor E4TF1-53",
        "protein_names_refseq": "GA binding protein transcription factor beta subunit 1; GA-binding protein subunit beta-1 isoform beta 1; GABP subunit beta-2; nuclear respiratory factor 2; transcription factor E4TF1-47; transcription factor E4TF1-53",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2553)",
        "pathway_count": 1,
        "publication_count": 51,
        "publication_id_list": "10675337;11237011;16959974;26154972;26992070;27600516;28832583;28834231;28904123;29242379;29351928;29485866;29557506;29632711;30524438;31154438;31844290;32157095;32350084;32357974;32488085;32502341;32897882;32938616;33091337;33298915;33346691;33592498;33758097;33912179;33936100;33968037;34019948;34087483;34932366;35051231;35318648;35343317;35580925;36010968;36284347;37217939;37938771;38665916;39531497;40596516;7799916;7918435;8383622;8441384;8816484",
        "class_list": "",
        "function": "(Microbial infection) Necessary for the expression of the Adenovirus E4 gene., [UniProtKB, PubMed]; Association of single nucleotide polymorphisms in the nuclear respiratory factor-2 beta subunit-encoding the GABPB1 gene within the occupational environment., [RefSeq, PubMed]; Association study of performance-related polymorphisms in Brazilian combat-sport athletes highlights variants in the GABPB1 gene., [RefSeq, PubMed]; Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage., [RefSeq, PubMed]; This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor capable of interacting with purine rich repeats (GA repeats) (PubMed:10675337, PubMed:8441384, PubMed:8816484). Acts as a master regulator of nuclear-encoded mitochondrial genes (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8IE52;Q06545;Q12940;Q12941;Q12942;Q8IYD0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007005 mitochondrion organization",
        "synthesized_glycan_count": 0,
        "hit_score": 5.7,
        "record_id": "Q06547-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q15788-1",
        "uniprot_id": "NCOA1_HUMAN",
        "mass": 156757.0,
        "length": 1441,
        "protein_name": "Nuclear receptor coactivator 1",
        "gene_name": "NCOA1",
        "organism": "Human",
        "refseq_name": "nuclear receptor coactivator 1 isoform 1",
        "refseq_ac": "NP_003734",
        "gene_names_uniprotkb": "NCOA1; BHLHE74; SRC1",
        "gene_names_refseq": "F-SRC-1; KAT13A; NCOA1; RIP160; SRC1; bHLHe42; bHLHe74",
        "protein_names_uniprotkb": "Nuclear receptor coactivator 1; 2.3.1.48; Class E basic helix-loop-helix protein 74; NCoA-1; Protein Hin-2; RIP160; Renal carcinoma antigen NY-REN-52; SRC-1; Steroid receptor coactivator 1; bHLHe74",
        "protein_names_refseq": "Hin-2 protein; class E basic helix-loop-helix protein 74; nuclear receptor coactivator 1 isoform 1; renal carcinoma antigen NY-REN-52; steroid receptor coactivator-1",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); thyroid hormone resistance syndrome (Disease Ontology:DOID:11633); hypothyroidism (Disease Ontology:DOID:1459); endometrial carcinoma (Disease Ontology:DOID:2871); breast carcinoma (Disease Ontology:DOID:3459); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:8648);  (R-HSA-1368108);  (R-HSA-159418);  (R-HSA-192105);  (R-HSA-193368);  (R-HSA-193807);  (R-HSA-1989781);  (R-HSA-211976);  (R-HSA-2151201);  (R-HSA-2426168);  (R-HSA-3214847);  (R-HSA-381340);  (R-HSA-3899300);  (R-HSA-400206);  (R-HSA-9018519);  (R-HSA-9029569);  (R-HSA-9623433);  (R-HSA-9707564);  (R-HSA-9707616);  (R-HSA-9841922);  (R-HSA-9844594);  (R-HSA-9931509);  (R-HSA-9933387)",
        "pathway_count": 23,
        "publication_count": 577,
        "publication_id_list": "10051404;10075656;10092594;10198158;10334992;10334993;10358072;10381560;10400691;10412986;10425206;10449719;10479480;10494028;10500157;10508479;10529898;10558993;10567404;10588945;10594042;10601278;10643692;10655068;10660621;10713165;10722692;10749848;10759542;10777541;10786633;10821277;10828826;10835357;10858438;10873660;10882139;10884298;10987286;11010967;11018023;11027271;11034064;11060344;11067870;11095972;11103799;11136970;11149950;11158055;11159893;11162494;11165043;11226238;11237011;11241162;11250900;11267664;11330046;11340167;11345900;11387216;11387316;11410592;11414710;11452016;11477070;11500512;11555828;11581164;11604492;11673457;11682626;11698662;11773079;11779144;11802775;11809803;11831720;11842083;11864604;11870371;11872672;11875109;11980911;12032151;12039952;12083769;12118000;12130498;12130638;12138096;12150943;12150977;12163482;12177166;12213831;12220224;12356737;12374852;12377782;12393883;12404239;12404240;12406875;12454263;12486725;12498683;12505311;12511571;12529333;12563009;12582161;12612073;12612088;12663868;12679040;12679481;12704183;12718889;12738229;12745923;12764144;12815072;12829629;12917342;12954634;12959972;12969439;1310260;13416382;1377680;1400444;14572640;14631847;14672706;14675539;14699511;14703507;14764426;14980219;15001666;15042513;15067378;15130092;15147902;15175654;15273253;15276198;15282324;15313887;15343269;15345050;15367689;15500444;15514030;15560782;15635043;15665827;15684387;15761026;15766567;15850785;15919796;15958389;15976810;15986123;16009131;16046058;16079181;16079853;16087863;16098147;16113099;1630819;16317684;16380219;16387653;16476485;16503871;16541101;16568091;16606617;16757475;16788062;16857194;16871576;16890199;16908160;16908542;16911507;16957778;16972786;16980581;17007889;17011499;17013392;17031457;17079232;17081986;1708392;17116691;17186944;17264172;17277772;17298944;17306620;17369852;1741400;17428193;17437997;17449569;17463000;17495528;17510434;17525332;17535915;17637753;17650074;17666587;17690249;17715127;17761950;17803295;17923681;17925399;17942393;17980149;18006707;18037887;18077418;18082607;18187655;18211901;18215119;18219272;18256232;18288277;18292238;18322535;18339323;18343819;18358809;18381289;18476782;18488044;18533032;18540824;18559965;18587630;18623064;18654640;18680753;18682402;18690216;18719978;18726356;18762174;18782758;18805503;18848529;18931025;19001277;19001364;19020303;19043829;19088433;19098913;19115207;19172745;19187765;19240082;19274700;19289416;19295514;19321454;19356719;19383337;19413330;19417006;19481530;19596686;19615980;19661213;1968462;19690164;19710360;19710929;1971514;19718048;19786558;19934321;19951946;19968714;19995069;20018852;20047962;20068231;20098713;20101261;20110263;20138239;20149798;20176810;2019602;20219941;20220130;2037576;20450493;20466882;20466885;20494359;20498280;20566875;20570965;20581824;20676127;20682797;20719759;20817722;20855588;20929863;20937905;21106759;21151129;21187453;21310851;21338522;21445275;21479263;21507939;21527249;21550420;21573489;21628546;21636783;2181374;21835891;21878914;21889235;21934649;21940756;22056668;22265404;22381047;22427940;22467880;22492511;22541735;22545144;2256920;22634312;22673513;22704330;22713328;22772592;22898188;23018617;23145106;23172872;23186163;23192763;23239344;23303788;23337244;23403292;23404503;23428468;23435229;23481700;23496987;23519696;23673342;23723241;23790976;23830809;2384150;23906331;24167369;24196956;24209621;24371278;24715725;24735615;24742681;24854081;24885040;24973012;24998469;25114211;25218447;25219498;25296600;25365482;2539258;25433557;25542856;25576301;25633194;25663755;25674852;25728767;25800734;2592361;26056233;26153859;26154972;26204489;26462610;26479350;26715851;26984517;26992070;27062924;27071062;2713875;27600516;27754849;27846572;27886276;27920218;28082258;28111073;28539435;28657654;28698372;28698609;28832583;28842423;28869506;28904123;2919170;29242379;29393594;29508533;29557506;29632711;29772548;29786170;2991279;3024157;3038528;3045126;30784271;30833945;31154438;31222486;31717259;31748741;31844290;31848261;31998317;32157095;32354867;32387766;32488085;32502341;32695117;3281094;32897882;32938616;33141586;33329381;3345742;33912179;33936100;33981976;34087483;34171305;3427020;34272753;34509645;3475708;3487786;3498214;35051231;35137184;35254053;35418691;35580925;36010968;3677090;37217939;37402091;37541260;38506084;39302247;39531497;40307207;6094553;7077161;7481822;7508385;7557095;7559524;7567999;7588781;7592729;7629110;7649182;7685352;7732023;7799916;7892212;7909540;7935485;7937828;7981125;8020941;8034703;8060328;8108407;8132774;8156598;8195246;8197458;8325954;8333869;8386511;8387517;8402897;8415693;8419924;8521497;8521498;8618898;8619637;8622974;8626466;8626488;8643605;8647822;8663599;8706692;8754792;8770873;8798690;8876171;8887638;8902629;8943006;8970730;8976377;9012850;9062340;9065481;9079689;9099716;9144434;9171241;9178750;9201922;9223281;9223431;9286700;9296499;9338790;9388265;9427644;9427757;9454824;9536209;9558366;9575154;9578606;9604010;9611253;9634533;9660774;9671459;9731700;9744270;9748239;9748295;9836620;9852097;9880483",
        "class_list": "",
        "function": "Dynamic interplay between corticosteroid treatment and the role of SRC-1 gene dysregulation in the progression of WHO-Grade 4 Astrocytoma., [RefSeq, PubMed]; Nuclear receptor coactivator SRC-1 promotes colorectal cancer progression through enhancing GLI2-mediated Hedgehog signaling., [RefSeq, PubMed]; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Obesity Due to Steroid Receptor Coactivator-1 Deficiency Is Associated With Endocrine and Metabolic Abnormalities., [RefSeq, PubMed]; PRRX1-NCOA1-rearranged fibroblastic tumour: a clinicopathological, immunohistochemical and molecular genetic study of six cases of a potentially under-recognised, distinctive mesenchymal tumour., [RefSeq, PubMed]; Steroid receptor coactivator 1 promotes human hepatocellular carcinoma invasiveness through enhancing MMP-9., [RefSeq, PubMed]; The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 30,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 57,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O00150;O43792;O43793;Q13071;Q13420;Q2T9G5;Q53SX3;Q6GVI5;Q7KYV3",
        "ec_number_list": "1.14.19.1;2.1.1.364;2.3.1.48;2.3.1.-;2.3.1.51;3.5.1.-;3.5.1.98;1.14.11.68;1.14.19.44;2.4.1.17;1.14.14.26;1.14.14.29;7.6.2.1;1.14.14.1;4.2.1.152;3.1.1.32;3.1.1.34;3.4.23.5;1.3.8.7;2.7.11.22;2.3.1.37;3.6.4.13;2.7.11.1;1.14.14.23;2.3.1.21;6.2.1.3;6.2.1.24;6.2.1.15;4.1.1.32;2.7.11.-;2.5.1.21;1.1.1.40;2.7.11.23;2.3.3.10;2.3.2.-;1.14.14.80;3.1.1.23;3.1.1.79;2.8.2.14;2.8.2.2;3.6.4.-;3.1.3.4;2.7.11.2;1.8.1.9;1.11.1.2;6.2.1.-;2.1.1.319;2.3.1.57;3.1.1.4;3.1.1.3;2.3.1.20;2.3.1.76;2.1.1.-;3.1.13.1;5.6.2.6;6.2.1.1;6.2.1.17;2.3.1.259;2.1.1.367;2.3.1.15;2.3.1.199;2.3.1.80",
        "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0046983 protein dimerization activity;GO:0044877 protein-containing complex binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0060179 male mating behavior;GO:1904179 positive regulation of adipose tissue development;GO:1900076 regulation of cellular response to insulin stimulus;GO:0043065 positive regulation of apoptotic process;GO:0045666 positive regulation of neuron differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 58.5,
        "record_id": "Q15788-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96MT3-1",
        "uniprot_id": "PRIC1_HUMAN",
        "mass": 94300.0,
        "length": 831,
        "protein_name": "Prickle-like protein 1",
        "gene_name": "PRICKLE1",
        "organism": "Human",
        "refseq_name": "prickle-like protein 1",
        "refseq_ac": "NP_001138353",
        "gene_names_uniprotkb": "PRICKLE1; RILP",
        "gene_names_refseq": "EPM1B; PRICKLE1; RILP",
        "protein_names_uniprotkb": "Prickle-like protein 1; REST/NRSF-interacting LIM domain protein 1",
        "protein_names_refseq": "REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein; REST/NRSF interacting LIM domain protein; REST/NRSF-interacting LIM domain protein 1; prickle homolog 1; prickle-like 1; prickle-like protein 1",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive Robinow syndrome (Disease Ontology:DOID:0060764); progressive myoclonus epilepsy 1B (Disease Ontology:DOID:0111448); velocardiofacial syndrome (Disease Ontology:DOID:12583); epilepsy (Disease Ontology:DOID:1826); temporal lobe epilepsy (Disease Ontology:DOID:3328); neural tube defects, susceptibility to (MONDO:MONDO:0020705)",
        "pathway": " (hsa:144165);  (R-HSA-4608870)",
        "pathway_count": 2,
        "publication_count": 39,
        "publication_id_list": "11237011;12525887;12724779;14645515;15937478;16442230;16687519;16764822;17411337;18976727;19379695;21276947;21901791;21983142;22037766;23140627;23481700;23535009;25576301;27862975;28832583;29242379;29557506;29671580;30429286;30564977;30971775;31844290;31848261;32157095;32938616;33592498;33936100;33968037;34001134;34171305;35051231;35580925;9674432",
        "class_list": "",
        "function": "Appears to serve as a nuclear receptor for REST/NRSF, REST4, and possibly other transcription factors, [RefSeq, PubMed]; Authors used a proteomic approach to identify protein complexes associated with PRICKLE1. The mRNA expression levels of the corresponding genes were assessed in 8982 patients with invasive primary breast cancer. AUthors then characterised the molecular interaction between PRICKLE1 and the guanine nucleotide exchange factor ECT2., [RefSeq, PubMed]; Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor., [UniProtKB, PubMed]; NRSF/REST functions as a repressor of TH transcription in NSCs via a mechanism dependent on the TH NRSE/RE1 sites., [RefSeq, PubMed]; PRICKLE1 and PRICKLE2 mRNAs were expressed together in brain, eye and testis., [RefSeq, PubMed]; PRICKLE1, a Wnt/PCP signaling component, is overexpressed and associated with inferior prognosis in acute myeloid leukemia. Publication Status: Online-Only, [RefSeq, PubMed]; Showed that the patient's father (p.Asp760del) and mother (p.Asp201Asn) each had a mutation in prickle1, [RefSeq, PubMed]; This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 9015,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 7,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14C83;Q71QF8;Q96N00",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0031965 nuclear membrane",
        "go_biological_process": "GO:0085029 extracellular matrix assembly;GO:0061326 renal tubule development;GO:0007409 axonogenesis;GO:0016358 dendrite development;GO:0090090 negative regulation of canonical Wnt signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "Q96MT3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P11473-1",
        "uniprot_id": "VDR_HUMAN",
        "mass": 48289.0,
        "length": 427,
        "protein_name": "Vitamin D3 receptor",
        "gene_name": "VDR",
        "organism": "Human",
        "refseq_name": "vitamin D3 receptor isoform VDRA",
        "refseq_ac": "NP_000367",
        "gene_names_uniprotkb": "VDR; NR1I1",
        "gene_names_refseq": "NR1I1; PPP1R163; VDR",
        "protein_names_uniprotkb": "Vitamin D3 receptor; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1; VDR",
        "protein_names_refseq": "1,25-dihydroxyvitamin D3 receptor; nuclear receptor subfamily 1 group I member 1; protein phosphatase 1, regulatory subunit 163; vitamin D (1,25- dihydroxyvitamin D3) receptor; vitamin D3 receptor isoform VDRA; vitamin D3 receptor",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); erythema nodosum (Disease Ontology:DOID:0080750); vitamin D-dependent rickets (Disease Ontology:DOID:0080883); vitamin D-dependent rickets type 2A (Disease Ontology:DOID:0080884); autosomal recessive limb-girdle muscular dystrophy type 2B (Disease Ontology:DOID:0110276); pigmentation disease (Disease Ontology:DOID:10123); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); rickets (Disease Ontology:DOID:10609); primary hyperparathyroidism (Disease Ontology:DOID:11202); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); gestational diabetes (Disease Ontology:DOID:11714); myopia (Disease Ontology:DOID:11830); otosclerosis (Disease Ontology:DOID:12185); primary biliary cholangitis (Disease Ontology:DOID:12236); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); secondary hyperparathyroidism (Disease Ontology:DOID:12466); Behcet's disease (Disease Ontology:DOID:13241); peptic esophagitis (Disease Ontology:DOID:13976); Parkinson's disease (Disease Ontology:DOID:14330); Fabry disease (Disease Ontology:DOID:14499); breast cancer (Disease Ontology:DOID:1612); male breast cancer (Disease Ontology:DOID:1614); aortic valve stenosis (Disease Ontology:DOID:1712); squamous cell carcinoma (Disease Ontology:DOID:1749); melanoma (Disease Ontology:DOID:1909); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); multiple sclerosis (Disease Ontology:DOID:2377); basal cell carcinoma (Disease Ontology:DOID:2513); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); atopic dermatitis (Disease Ontology:DOID:3310); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); Turner syndrome (Disease Ontology:DOID:3491); tuberculosis (Disease Ontology:DOID:399); esophagus adenocarcinoma (Disease Ontology:DOID:4914); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); hematopoietic system disease (Disease Ontology:DOID:74); retinal degeneration (Disease Ontology:DOID:8466); psoriasis (Disease Ontology:DOID:8893); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); Barrett's esophagus (Disease Ontology:DOID:9206); diabetes mellitus (Disease Ontology:DOID:9351); cholangitis (Disease Ontology:DOID:9446); steatotic liver disease (Disease Ontology:DOID:9452); alopecia (Disease Ontology:DOID:987); Mycobacterium tuberculosis, susceptibility (MONDO:MONDO:0000070)",
        "pathway": " (hsa:7421);  (R-HSA-196791);  (R-HSA-383280);  (R-HSA-4090294)",
        "pathway_count": 4,
        "publication_count": 144,
        "publication_id_list": "10052453;10235266;10518789;10542397;10678179;10866662;11012668;11085925;11121022;11234559;11237011;11344298;11717447;11799400;11856765;11865025;11980721;12016314;12077349;12144530;12145331;12177000;12227689;12855575;12867411;1324736;14500761;14665442;15032981;15055995;15175151;15192080;15192092;15225774;15465040;15474498;15647825;15728261;15896744;15923626;15961505;16103106;16207705;16252006;16252240;1652893;1656468;16751179;16912044;16913708;17020914;17105732;17218271;17314004;17368182;17717077;17970811;1850412;19041634;19211567;19473635;19692572;19850744;19864602;19955185;20159957;20719936;21467194;21595846;2177843;21849106;22323358;22564762;22877430;22879719;22918710;22930759;23546875;23857223;24101867;24569127;25114211;25363733;25576301;26154972;26434738;26748501;26992070;27250744;27397612;27913313;28005175;28206978;2835767;2849209;28698609;28832583;28841848;28904123;29242379;29393594;29493099;29557506;29789417;30379171;30468856;31844290;32157095;32354638;32387766;32488085;32938616;32983136;33141586;33298915;33392160;33537174;33912179;33968037;35580925;36284347;37478846;39394075;39419237;39445578;7768901;7828346;8106618;8381803;8384219;8392065;8392085;8506296;8622969;8675579;8679605;8706697;8961271;9005998;9212063;9267036;9632709;9653119;9821970",
        "class_list": "",
        "function": "Assessment of the contribution of VDR and VDBP/GC genes in the pathogenesis of celiac disease., [RefSeq, PubMed]; Association of Vitamin D receptor gene polymorphism with susceptibility and prognosis of Systemic Lupus Erythematosus in Chinese patients., [RefSeq, PubMed]; Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and meta-analysis. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:10678179, PubMed:15728261, PubMed:16913708, PubMed:28698609, PubMed:37478846). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609). Plays a central role in calcium homeostasis (By similarity). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (PubMed:12016314, PubMed:32354638)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 59,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5Q1;G3V1V9;Q5PSV3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0043235 receptor complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0042359 vitamin D metabolic process;GO:0070561 vitamin D receptor signaling pathway;GO:0038185 nuclear receptor-mediated bile acid signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 14.7,
        "record_id": "P11473-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00165-1",
        "uniprot_id": "HAX1_HUMAN",
        "mass": 31621.0,
        "length": 279,
        "protein_name": "HCLS1-associated protein X-1",
        "gene_name": "HAX1",
        "organism": "Human",
        "refseq_name": "HCLS1-associated protein X-1 isoform b",
        "refseq_ac": "NP_001018238",
        "gene_names_uniprotkb": "HAX1; HS1BP1",
        "gene_names_refseq": "HAX1; HCLSBP1; HS1BP1; SCN3",
        "protein_names_uniprotkb": "HCLS1-associated protein X-1; HAX-1; HS1-associating protein X-1; HS1-binding protein 1; HSP1BP-1",
        "protein_names_refseq": "HAX-1; HCLS1 (and PKD2) associated protein; HCLS1-associated protein X-1 isoform b; HS1 binding protein; HS1-associating protein X-1; HS1-binding protein 1; HSP1BP-1",
        "tax_id": 9606,
        "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); severe congenital neutropenia 3 (Disease Ontology:DOID:0112133)",
        "pathway": " (hsa:10456)",
        "pathway_count": 1,
        "publication_count": 82,
        "publication_id_list": "10760273;11237011;12042320;12787133;15104674;15159385;15339924;16857965;17187068;17241641;17545607;18319618;18337561;18472110;18971376;19796188;20112406;20171186;20220065;20665473;22121020;23164465;23186163;23481700;24188827;24714562;24715725;25298122;25418920;25469497;25505266;25576301;26154972;26375851;26527684;26728094;26915802;26992070;26997484;27600516;27846572;27862975;28218747;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29632711;29786170;30315122;30429286;31154438;31217245;31844290;31848261;31998317;32157095;32161166;32502341;32897882;33298915;33691108;33912179;33936100;33968037;34561969;35254053;35561310;35580925;37193639;37488967;37742722;38514606;38769438;40596516;40914422;9058808",
        "class_list": "",
        "function": "Energy stress promotes P-bodies formation via lysine-63-linked polyubiquitination of HAX1., [RefSeq, PubMed]; HAX-1 binds bile salt export protein (BSEP), cortactin, MDR1, and MDR2. HAX-1 and cortactin regulate BSEP abundance in the apical membrane of cells., [RefSeq, PubMed]; HAX1 is a novel binding partner of Che-1/AATF. Implications in oxidative stress cell response., [RefSeq, PubMed]; HAX1-related congenital neutropenia: Long-term observation in paediatric and adult patients enrolled in the European branch of the Severe Chronic Neutropenia International Registry (SCNIR)., [RefSeq, PubMed]; In psoriasis, the epidermal differentiation could be disturbed due to the increased expression of HAX-1 and hence a prolonged resistance to terminal differentiation, [RefSeq, PubMed]; NOD1 cooperates with HAX-1 to promote cell migration in a RIPK2- and NF-kB-independent manner., [RefSeq, PubMed]; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8W4W9;A8W4X0;B4DUJ7;Q5VYD5;Q5VYD7;Q96AU4;Q9BS80",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0019966 interleukin-1 binding;GO:0035591 signaling adaptor activity",
        "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0030854 positive regulation of granulocyte differentiation;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1903146 regulation of autophagy of mitochondrion",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "O00165-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q01105-1",
        "uniprot_id": "SET_HUMAN",
        "mass": 33489.0,
        "length": 290,
        "protein_name": "Protein SET",
        "gene_name": "SET",
        "organism": "Human",
        "refseq_name": "protein SET isoform 4",
        "refseq_ac": "NP_001234930",
        "gene_names_uniprotkb": "SET",
        "gene_names_refseq": "2PP2A; I2PP2A; IGAAD; IPP2A2; MRD58; PHAPII; SET; TAF-IBETA; TAF-I",
        "protein_names_uniprotkb": "Protein SET; HLA-DR-associated protein II; I-2PP2A; IGAAD; Inhibitor of granzyme A-activated DNase; PHAPII; Phosphatase 2A inhibitor I2PP2A; TAF-I; Template-activating factor I",
        "protein_names_refseq": "HLA-DR-associated protein II; SET nuclear oncogene; SET translocation (myeloid leukemia-associated); Template-Activating Factor-I, chromatin remodelling factor; inhibitor of granzyme A-activated DNase; inhibitor-2 of protein phosphatase-2A; phosphatase 2A inhibitor I2PP2A; protein SET isoform 4; protein phosphatase type 2A inhibitor",
        "tax_id": 9606,
        "disease": "autosomal dominant intellectual developmental disorder 58 (Disease Ontology:DOID:0061032)",
        "pathway": " (hsa:6418);  (R-HSA-2299718);  (R-HSA-450520)",
        "pathway_count": 3,
        "publication_count": 143,
        "publication_id_list": "10.1101/2023.09.13.557529;11018049;11163245;11231286;11237011;11555662;11834731;11909973;12086618;12208845;12524539;12628186;12917472;14981256;15257295;15642345;15750587;1630450;16484227;16541025;16818237;17081983;17178712;17360516;17392515;17517897;17924679;18211953;18285462;18367646;18718915;19130553;19343227;19608861;20068231;20086103;20551165;20551166;20622854;20966048;21498573;21515671;21872626;21911480;21993680;22424782;22645359;23186163;23481700;23498719;23783831;24275569;24714562;24715725;25356899;25502872;25576301;25645385;25810538;25880248;25892735;26154972;26375851;26992070;27543614;27600516;27862975;28218747;28228285;28510447;28514659;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29688601;29786170;29789417;30315122;30379171;30410026;30524438;31154438;31217245;31844290;31937595;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33091337;33123756;33141586;33298915;33465208;33592498;33633747;33717175;33912179;33968037;33981976;34019948;34087483;34171305;34211107;34357683;34405274;34509645;34932366;35051231;35138101;35251023;35318648;35580925;36010968;37794134;37938771;38141761;38277454;38355937;38555840;38665916;40596516;40914422;40930100;7753797;8192856;8294483;8626647;9773788",
        "class_list": "",
        "function": "HMGB1/SET/HAT1 complex-mediated SASH1 repression drives glycolysis and metastasis in lung adenocarcinoma., [RefSeq, PubMed]; Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher., [UniProtKB, PubMed, PubMed]; Oncoprotein SET-associated transcription factor ZBTB11 triggers lung cancer metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; PP2A complex disruptor SET prompts widespread hypertranscription of growth-essential genes in the pancreatic cancer cells., [RefSeq, PubMed]; PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells., [RefSeq, PubMed]; The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]., [RefSeq]; USP7 interacts with and destabilizes oncoprotein SET., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5A5H4;A6NGV1;B4DUE2;Q15541;Q5VXV1;Q5VXV2;Q6FHZ5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0019888 protein phosphatase regulator activity;GO:0042393 histone binding;GO:0004864 protein phosphatase inhibitor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet",
        "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription;GO:0043524 negative regulation of neuron apoptotic process;GO:0006260 DNA replication;GO:0006334 nucleosome assembly;GO:0006337 nucleosome disassembly",
        "synthesized_glycan_count": 0,
        "hit_score": 14.8,
        "record_id": "Q01105-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WXE9-1",
        "uniprot_id": "STON2_HUMAN",
        "mass": 101165.0,
        "length": 905,
        "protein_name": "Stonin-2",
        "gene_name": "STON2",
        "organism": "Human",
        "refseq_name": "stonin-2 isoform 2",
        "refseq_ac": "NP_001243359",
        "gene_names_uniprotkb": "STON2; STN2; STNB",
        "gene_names_refseq": "STN2; STNB2; STNB; STON2",
        "protein_names_uniprotkb": "Stonin-2; Stoned B",
        "protein_names_refseq": "stoned B homolog 2; stonin-2 isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:85439);  (R-HSA-8856825);  (R-HSA-8856828)",
        "pathway_count": 3,
        "publication_count": 218,
        "publication_id_list": "10.1101/2023.09.13.557529;10097102;10436022;10535736;10542231;10559856;10559861;10559924;10567358;10613896;10625686;10766823;10769163;10983987;11071885;11076969;11082044;11231140;11237011;11239472;11247302;11381094;11454741;11470803;11516654;11517213;11532990;11577110;11588219;11877457;11877461;11889126;11919637;11927540;11988742;12057195;12086608;12213833;12221107;12234931;12429842;12447393;12451172;12464600;12717448;12847086;12944396;12952949;12958364;1317852;14555962;14581451;14617351;14622578;14622579;14662753;14726597;15134832;15252009;15260957;15318165;15339664;1535555;15473838;15502812;15502813;15649145;15671180;15703209;15728179;15802264;15895077;15916959;16103228;16159959;16215232;16326391;16410077;16459302;16460808;16516836;16707488;16723738;16798879;16880396;16903783;17018281;17035995;17158794;17267500;17360967;17456551;17494869;17512409;17522231;17540576;17609109;17681954;17713526;17762867;17765681;17978091;18032517;18093523;18166656;18199683;18200045;18388313;1847920;18691976;18775314;18790740;18819912;18981233;19092055;19140243;19287005;19296720;19458185;19536138;19575674;19603039;1968060;19696796;19696798;19713939;19732400;19776351;19809571;19853559;20033059;20059951;20112406;20211604;20231386;20351096;20428113;20448150;20826345;20946875;21102408;2115402;21187331;21278753;21316588;21445324;21482805;21499258;21613550;21779028;21841790;21883765;21927000;21927001;21962517;21995445;22099461;22118466;22233676;22357968;22484487;22505844;2257624;22815487;22863004;22942912;23186163;23297414;23536704;23823722;23861397;23891661;24130457;24186068;24384571;24581490;24680432;24746795;24789820;24966051;25107275;25303366;25341920;26042225;26403691;26829388;2890644;29557506;31154438;31844290;31848261;32737415;33091337;33592498;34087483;3417785;35051231;35580925;36702439;38253038;6146630;7569928;7822302;7877694;8524399;8552632;8553074;8837779;9092476;9100026;9169477;9303539;9427626;9428629;9635431;9723620;9736607;9812899",
        "class_list": "",
        "function": "Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Keratoconus-susceptibility gene identification by corneal thickness genome-wide association study and artificial intelligence IBM Watson. Publication Status: Online-Only, [RefSeq, PubMed]; Our data identify the molecular determinants for recognition of synaptotagmin by stonin 2 or its Caenorhabditis elegans orthologue UNC-41B., [RefSeq, PubMed]; Stonin 2 activates lysosomal-mTOR axis for cell survival in oral cancer., [RefSeq, PubMed]; The ability of stonin 2 to facilitate endocytosis of synaptotagmin is dependent on its association with AP-2, an intact mu-homology domain, and functional AP-2 heterotetramers., [RefSeq, PubMed]; This gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific proteins are internalized. The encoded protein has also been shown to participate in synaptic vesicle recycling through interaction with synaptotagmin 1 required for neurotransmission. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "G3V2T7;Q17R24;Q59H11;Q6NT47;Q96RI7;Q96RU6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0035615 clathrin adaptor activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0043005 neuron projection;GO:0030122 AP-2 adaptor complex;GO:0008021 synaptic vesicle;GO:0030121 AP-1 adaptor complex",
        "go_biological_process": "GO:0030100 regulation of endocytosis;GO:0072583 clathrin-dependent endocytosis;GO:0048488 synaptic vesicle endocytosis;GO:0006897 endocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 22.6,
        "record_id": "Q8WXE9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P05060-1",
        "uniprot_id": "SCG1_HUMAN",
        "mass": 78276.0,
        "length": 677,
        "protein_name": "Secretogranin-1",
        "gene_name": "CHGB",
        "organism": "Human",
        "refseq_name": "secretogranin-1 precursor",
        "refseq_ac": "NP_001810",
        "gene_names_uniprotkb": "CHGB; SCG1",
        "gene_names_refseq": "CHGB; SCG1",
        "protein_names_uniprotkb": "Secretogranin-1; CgB; Chromogranin-B; Secretogranin I; SgI",
        "protein_names_refseq": "cgB; secretogranin B; secretogranin I; secretogranin-1 precursor; secretogranin-1; sgI",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:1114);  (R-HSA-381426);  (R-HSA-8957275)",
        "pathway_count": 3,
        "publication_count": 92,
        "publication_id_list": "10.1038/emboj.2013.79;10026136;10077652;10218588;10512690;10614670;10681634;10810289;10898936;10912521;10951195;10990447;11158056;11237011;11250653;11264294;11316783;11522292;11606061;11739083;11751371;11788658;12241545;12379487;12466191;12810533;12904166;1370451;1383255;14997482;15126567;15308688;15469690;15485880;15525596;15642270;16807684;17047378;17249697;17312271;17985932;18702456;1882087;20187088;23234360;23584533;24275569;24715725;2476804;2479552;25326458;26091039;29557506;29741879;30078552;30451732;30887724;31154438;31848261;32928873;33392160;35051231;35251023;35494241;3608978;36095079;36511243;3678488;37453717;37938771;3970711;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7683646;7689487;7784254;8781553;8817670;8894645;8964575;9497324;9709957;9733769;9786878;9922210",
        "class_list": "",
        "function": "Chromogranin B in blood serum of patients with neuroendocrine tumors.', trans 'capital HA, Cyrillicsmall er, Cyrillicsmall o, Cyrillicsmall em, Cyrillicsmall o, Cyrillicsmall ghe, Cyrillicsmall er, Cyrillicsmall a, Cyrillicsmall en, Cyrillicsmall i, Cyrillicsmall en, Cyrillic capital VE, Cyrillic small ve, Cyrillic small es, Cyrillicsmall yeru, Cyrillicsmall ve, Cyrillicsmall o, Cyrillicsmall er, Cyrillicsmall o, Cyril..., [RefSeq, PubMed]; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides., [UniProtKB]; Serum levels of CgA, CgB, and SgII were determined in Parkinson's disease patients and assessed their association with disease severity., [RefSeq, PubMed]; The mechanisms of chromogranin B-regulated Cl- homeostasis., [RefSeq, PubMed]; These data collectively point out CHGB as a possible preoperative and postoperative marker for pheochromocytomas and abdominal paragangliomas with potential for aggressive behavior, [RefSeq, PubMed]; This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 2,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 27,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K021;Q59EU9;Q6IBS6;Q9BQV6;Q9UC25;Q9UJA6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005179 hormone activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0030141 secretory granule;GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 9.9,
        "record_id": "P05060-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q00403-1",
        "uniprot_id": "TF2B_HUMAN",
        "mass": 34833.0,
        "length": 316,
        "protein_name": "Transcription initiation factor IIB",
        "gene_name": "GTF2B",
        "organism": "Human",
        "refseq_name": "transcription initiation factor IIB",
        "refseq_ac": "NP_001505",
        "gene_names_uniprotkb": "GTF2B; TF2B; TFIIB",
        "gene_names_refseq": "GTF2B; TF2B; TFIIB",
        "protein_names_uniprotkb": "Transcription initiation factor IIB; 2.3.1.48; General transcription factor TFIIB; S300-II",
        "protein_names_refseq": "RNA polymerase II transcription factor IIB; S300-II; general transcription factor TFIIB; transcription initiation factor IIB",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2959);  (R-HSA-167161);  (R-HSA-167162);  (R-HSA-167172);  (R-HSA-674695);  (R-HSA-6807505);  (R-HSA-73776);  (R-HSA-73779);  (R-HSA-75953);  (R-HSA-76042)",
        "pathway_count": 10,
        "publication_count": 186,
        "publication_id_list": "10022900;10024882;10199401;10318856;10359081;10619841;10723029;11005381;11045620;11237011;11433015;11486021;11739720;11784853;11856838;11859374;11884399;12414730;12574128;12676794;12931194;1310361;14641108;14701755;1517211;1535687;15489290;15654739;16230532;16239144;16308568;16901896;16959974;1739980;18079403;1829677;18669648;1876184;18991276;19054851;1939271;1946368;19667075;19690332;20226668;20457598;2125285;22137580;22231121;22252320;22441827;2247058;22645359;23115335;23166507;23186163;23932780;24097444;24270878;24366607;24397554;24441171;2449431;24714562;24715725;24997600;25418920;25576301;25675981;26024233;26154972;26758079;26811146;26992070;27193682;27600516;27846572;27862975;27920218;28218747;28228285;28510447;28832583;28904123;29158257;29242379;29331515;29393594;29437277;2944599;29493099;29557506;29632046;29789417;3029109;30315122;30410026;30429286;30484775;30833945;31217245;31222486;31530632;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33123756;33141586;33298915;33392160;33592498;33633747;33691108;33717175;33912179;33936100;33968037;34019948;34078123;34087483;34171305;34932366;34932801;35051231;35251023;35318648;35580925;35947745;36010968;36215666;36241641;36284347;37938771;3818643;39601751;39894887;7151173;7601352;7660122;7660129;7660130;7671313;7675079;7715707;7983760;8156590;8253082;8330735;8339931;8370526;8392607;8413225;8465201;8490964;8504927;8515819;8515820;8516311;8516312;8566795;8628262;8662660;8668525;8800208;8946909;9009278;9153304;9188510;9256425;9353262;9405375;9407024;9420329;9450929;9489704;9609687;9705341;9832505",
        "class_list": "",
        "function": "Differential dependencies of human RNA polymerase II promoters on TBP, TAF1, TFIIB and XPB., [RefSeq, PubMed]; General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:12931194, PubMed:1517211, PubMed:1876184, PubMed:1946368, PubMed:27193682, PubMed:3029109, PubMed:3818643, PubMed:7601352, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:9420329). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8413225, PubMed:8504927, PubMed:8515820, PubMed:8516311, PubMed:8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352). Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:10619841, PubMed:16230532, PubMed:7675079, PubMed:9420329). Modulates transcription start site selection (PubMed:10318856). Also exhibits autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor GTF2B regulates AIP protein expression in growth hormone-secreting pituitary adenomas and influences tumor phenotypes., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 30,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K1A7;Q5JS30",
        "ec_number_list": "2.3.1.48;2.3.1.-;5.6.2.3;5.6.2.4;2.7.11.1;3.1.13.-;2.7.7.48;2.7.7.6;2.7.11.22;2.7.11.23;2.7.11.24;3.1.27.-;3.1.3.16;2.3.1.57;2.3.1.259;2.3.1.80",
        "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0008270 zinc ion binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0000993 RNA polymerase II complex binding;GO:0046966 nuclear thyroid hormone receptor binding",
        "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000776 kinetochore",
        "go_biological_process": "GO:0019083 viral transcription;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006473 protein acetylation;GO:0051225 spindle assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 18.9,
        "record_id": "Q00403-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9P0N8-1",
        "uniprot_id": "MARH2_HUMAN",
        "mass": 26995.0,
        "length": 246,
        "protein_name": "E3 ubiquitin-protein ligase MARCHF2",
        "gene_name": "MARCHF2",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase MARCHF2 isoform 1",
        "refseq_ac": "NP_001005415",
        "gene_names_uniprotkb": "MARCHF2; HSPC240; MARCH2; RNF172",
        "gene_names_refseq": "HSPC240; MARCH-II; MARCH2; MARCHF2; RNF172",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF2; 2.3.2.27; MARCH-II; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; RING finger protein 172; RING-type E3 ubiquitin transferase MARCHF2",
        "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH2; E3 ubiquitin-protein ligase MARCHF2 isoform 1; E3 ubiquitin-protein ligase MARCHF2; RING finger protein 172; RING-type E3 ubiquitin transferase MARCH2; RING-type E3 ubiquitin transferase MARCHF2; membrane associated ring finger 2; membrane-associated RING finger protein 2; membrane-associated RING-CH protein II; membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51257)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "11237011;14722266;15689499;16428329;17980554;23166351;23818989;29573664;31142615;32935379;34357683;38299743;38457262;38722959;38848952",
        "class_list": "",
        "function": "(Microbial infection) Positively regulates the degradation of Vesicular stomatitis virus (VSV) G protein via the lysosomal degradation pathway (PubMed:29573664). Represses HIV-1 viral production and may inhibit the translocation of HIV-1 env to the cell surface, resulting in decreased viral cell-cell transmission (PubMed:29573664)., [UniProtKB, PubMed]; Depletion of MARCH-II by small interfering RNA perturbed the trans-Golgi network (TGN) localization of syntaxin 6 and TGN38/46, [RefSeq, PubMed]; E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:14722266, PubMed:16428329). Together with GOPC/CAL mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Ubiquitinates and therefore mediates the degradation of DLG1 (PubMed:17980554). Regulates the intracellular trafficking and secretion of alpha1-antitrypsin/SERPINA1 and HP/haptoglobin via ubiquitination and degradation of the cargo receptor ERGIC3 (PubMed:31142615). Negatively regulates the antiviral and antibacterial immune response by repression of the NF-kB and type 1 IFN signaling pathways, via MARCHF2-mediated K48-linked polyubiquitination of IKBKG/NEMO, resulting in its proteasomal degradation (PubMed:32935379). May be involved in endosomal trafficking through interaction with STX6 (PubMed:15689499)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Human MARCH1, 2, and 8 block Ebola virus envelope glycoprotein cleavage via targeting furin P domain., [RefSeq, PubMed]; KLF15-activated MARCH2 boosts cell proliferation and epithelial-mesenchymal transition and presents diagnostic significance for hepatocellular carcinoma., [RefSeq, PubMed]; MARCH family E3 ubiquitin ligases selectively target and degrade cadherin family proteins. Publication Status: Online-Only, [RefSeq, PubMed]; MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]., [RefSeq]; MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NP10;Q5H785;Q8N5A3;Q96B78",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane",
        "go_biological_process": "GO:0044790 suppression of viral release by host;GO:1905167 positive regulation of lysosomal protein catabolic process;GO:0006897 endocytosis;GO:0016567 protein ubiquitination;GO:0140374 antiviral innate immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q9P0N8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96BH3-1",
        "uniprot_id": "ESPB1_HUMAN",
        "mass": 26106.0,
        "length": 223,
        "protein_name": "Epididymal sperm-binding protein 1",
        "gene_name": "ELSPBP1",
        "organism": "Human",
        "refseq_name": "epididymal sperm-binding protein 1 precursor",
        "refseq_ac": "NP_071425",
        "gene_names_uniprotkb": "ELSPBP1; E12",
        "gene_names_refseq": "E12; EDDM12; EL149; ELSPBP1; HE12",
        "protein_names_uniprotkb": "Epididymal sperm-binding protein 1; Epididymal secretory protein 12; hE12",
        "protein_names_refseq": "epididymal protein 12; epididymal secretory protein 12; epididymal sperm-binding protein 1 precursor; epididymis luminal secretory protein 149; epididymis secretory sperm binding protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64100)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "10.1101/2023.09.13.557529;11144225;11237011;17307309;17910069;20503194;25817725;29242379",
        "class_list": "",
        "function": "Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity (By similarity)., [UniProtKB]; Characterize the assembly of a five-component complex containing TAL1, LMO2, Ldb1, E12, and DNA. The bHLH domains of TAL1 and E12 alone primarily formed helical homodimers, but together formed heterodimers, to which LMO2 bound with high affinity, [RefSeq, PubMed]; HCV core protein represses E-cadherin expression by upregulating E12/E47 levels to induce EMT in HCV-associated HCC., [RefSeq, PubMed]; Sperm-binding fibronectin type II-module proteins are genetically linked and functionally related., [RefSeq, PubMed]; The protein encoded by this gene belongs to the sperm-coating protein family of epididymal origin. This protein and its canine homolog are the first known examples of proteins with four tandemly arranged fibronectin type 2 (Fn2) domains in the Fn2-module protein family. [provided by RefSeq, Jul 2008]., [RefSeq]; These biochemical and functional data reveal RANBP16 and RANBP17 as novel regulators of E2A protein action, and demonstrate specific interaction of E12 with RANBP17., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96RT0;Q9H4C8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008201 heparin binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface",
        "go_biological_process": "GO:0007338 single fertilization;GO:0048240 sperm capacitation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q96BH3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60645-1",
        "uniprot_id": "EXOC3_HUMAN",
        "mass": 85567.0,
        "length": 745,
        "protein_name": "Exocyst complex component 3",
        "gene_name": "EXOC3",
        "organism": "Human",
        "refseq_name": "exocyst complex component 3",
        "refseq_ac": "NP_009208",
        "gene_names_uniprotkb": "EXOC3; SEC6L1; SEC6",
        "gene_names_refseq": "EXOC3; SEC6L1; SEC6; Sec6p",
        "protein_names_uniprotkb": "Exocyst complex component 3; Exocyst complex component Sec6",
        "protein_names_refseq": "SEC6-like 1; Sec 6 homolog; exocyst complex component 3; exocyst complex component Sec6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11336);  (R-HSA-1445148);  (R-HSA-264876);  (R-HSA-5620916)",
        "pathway_count": 4,
        "publication_count": 155,
        "publication_id_list": "10521251;11237011;11462236;11493706;11707400;11904301;12221131;14617756;14704853;15158452;1528899;15331542;15728366;15878854;15919790;15971998;16038802;16136078;16155582;16158220;16158222;16407158;16431365;16537653;16714477;16782012;16880201;16984975;17007872;17030804;17369524;17574030;17628206;17646400;17956946;17995453;18329369;18685082;18756269;19013499;19017632;19153612;19252894;19297529;19454479;19608861;19664995;20083215;20308425;20308558;20631154;20701589;20736409;20837646;20937701;21091435;21145486;21273506;21308844;21454505;21454690;21550243;21565611;21713314;21775626;21907143;22389062;22420621;22433857;22645359;22983554;23351793;23567335;23945166;24296415;24366607;24715725;25091901;25418920;2550440;25576301;25645385;25880248;26154972;26375851;2669954;26992070;27862975;27920218;28218747;2822027;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29557506;29729335;29786170;30315122;30429286;30484775;30524438;31154438;31184304;31530632;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32723473;32897882;32938616;32983136;33141586;33298915;33485965;33592498;33691108;33717175;33912179;33968037;34087483;34171305;34509645;34561969;34932366;35051231;35318648;35494241;35561310;35580925;36010968;36241641;36284347;37938771;38007759;3896518;7626024;8094051;8664345;8916141;9166668;9207799;9631292;9819391",
        "class_list": "",
        "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB]; Sec6 increased the phosphorylation of p38 MAPK through the activation of MAPK kinase 3/6 (MKK3/6). Moreover, Sec6 knockdown suppressed the phosphorylation of HSP27 at Ser(78) and Ser(82) sites via suppression of activated MK2., [RefSeq, PubMed]; Structural Study of the Exocyst Subunit Human Sec6., [RefSeq, PubMed]; The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6P2E8;Q8TEN6;Q8WUW0;Q96DI4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0045296 cadherin binding;GO:0000149 SNARE binding",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030426 growth cone;GO:0048471 perinuclear region of cytoplasm;GO:0030667 secretory granule membrane",
        "go_biological_process": "GO:0051601 exocyst localization;GO:0015031 protein transport;GO:0000281 mitotic cytokinesis;GO:0006887 exocytosis;GO:0090148 membrane fission",
        "synthesized_glycan_count": 0,
        "hit_score": 15.6,
        "record_id": "O60645-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0CF97-1",
        "uniprot_id": "F200B_HUMAN",
        "mass": 76034.0,
        "length": 657,
        "protein_name": "Protein FAM200B",
        "gene_name": "FAM200B",
        "organism": "Human",
        "refseq_name": "protein FAM200B",
        "refseq_ac": "NP_001138663",
        "gene_names_uniprotkb": "FAM200B; C4orf53",
        "gene_names_refseq": "C4orf53; FAM200B; ZBED11",
        "protein_names_uniprotkb": "Protein FAM200B",
        "protein_names_refseq": "Putative protein FAM200B; family with sequence similarity 200 member B; protein FAM200B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:285550)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11237011;25892735;29557506;29769354;30379171;31844290;35051231;36215666;36241641",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "P0CF97-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14517-1",
        "uniprot_id": "FAT1_HUMAN",
        "mass": 506273.0,
        "length": 4588,
        "protein_name": "Protocadherin Fat 1",
        "gene_name": "FAT1",
        "organism": "Human",
        "refseq_name": "protocadherin Fat 1 isoform 1 precursor",
        "refseq_ac": "NP_005236",
        "gene_names_uniprotkb": "FAT1; CDHF7; FAT",
        "gene_names_refseq": "CDHF7; CDHR8; FAT1; FAT; ME5; hFat1",
        "protein_names_uniprotkb": "Protocadherin Fat 1; Cadherin family member 7; Cadherin-related tumor suppressor homolog; Protein fat homolog",
        "protein_names_refseq": "FAT tumor suppressor 1; cadherin ME5; cadherin family member 7; cadherin-related family member 8; cadherin-related tumor suppressor homolog; protein fat homolog; protocadherin Fat 1 isoform 1 precursor; protocadherin Fat 1",
        "tax_id": 9606,
        "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); facioscapulohumeral muscular dystrophy (Disease Ontology:DOID:11727); nephrotic syndrome (Disease Ontology:DOID:1184); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung small cell carcinoma (Disease Ontology:DOID:5409); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:2195)",
        "pathway_count": 1,
        "publication_count": 90,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;11237011;15922730;17081983;17525332;18220336;18578522;19131340;19159218;19349973;19413330;20068231;20934997;23090970;23481700;23584533;24190977;25576301;25645385;25813380;26154972;26566883;26992070;27600516;27726376;27846572;28228285;28832583;29053796;29093164;29242379;29393594;29508533;29557506;29786170;29789417;30379171;30429286;30484775;30779550;30833945;31154438;31217245;31222486;31530632;31844290;31848261;31937595;32157095;32161166;32350084;32357974;32387766;32488085;32983136;33043033;33141586;33392160;33537174;33592498;33912179;33968037;33981976;34087483;34171305;34185709;34411563;34509645;34932366;35051231;35154160;35318648;35494241;35580925;36010968;36215666;36241641;36284347;37074911;37931687;37938771;37952564;38253038;38364976;38640981;38665916;38986165;8586420",
        "class_list": "",
        "function": "Clinical value of FAT1 mutations to indicate the immune response in colorectal cancer patients., [RefSeq, PubMed]; FAT1 as a tumor mutation burden specific gene affects the immunotherapy effect in head and neck squamous cell cancer., [RefSeq, PubMed]; FAT1 inhibits AML autophagy and proliferation via downregulating ATG4B expression., [RefSeq, PubMed]; Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact., [UniProtKB]; Predictive capacity of FAT1 transcriptional expression in patients with head and neck squamous cell carcinomas treated with radiotherapy., [RefSeq, PubMed]; STAT1 mediated downregulation of the tumor suppressor gene PDCD4, is driven by the atypical cadherin FAT1, in glioblastoma., [RefSeq, PubMed]; This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 17,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 18,
        "reported_o_glycosites_with_glycan": 10,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 18,
        "total_reported_o_glycosites": 10,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 18,
        "total_o_glycosites": 10,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 3,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 657,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 32,
        "disease_count": 7,
        "glyco_site_count": 35,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0005925 focal adhesion",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0007267 cell-cell signaling;GO:0016477 cell migration;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0009653 anatomical structure morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 15.1,
        "record_id": "Q14517-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q15942-1",
        "uniprot_id": "ZYX_HUMAN",
        "mass": 61277.0,
        "length": 572,
        "protein_name": "Zyxin",
        "gene_name": "ZYX",
        "organism": "Human",
        "refseq_name": "zyxin isoform 1",
        "refseq_ac": "NP_001010972",
        "gene_names_uniprotkb": "ZYX",
        "gene_names_refseq": "ESP-2; HED-2; ZYX",
        "protein_names_uniprotkb": "Zyxin; Zyxin-2",
        "protein_names_refseq": "zyxin isoform 1; zyxin-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7791)",
        "pathway_count": 1,
        "publication_count": 117,
        "publication_id_list": "10801818;11237011;11689660;12695497;15302935;16885336;16964243;17081983;17287340;17322306;17572661;17924679;18088087;18158903;18212344;18220336;18297730;18452278;18491316;18578522;18669648;18707149;18767875;19413330;19415658;19608861;19651622;19664994;19664995;20058876;20068231;20166139;21406692;23186163;23233529;23301498;24129315;24275569;25802875;26154972;26992070;27655845;27846572;27862975;28510447;28657654;28832583;29237092;29242379;29314611;29351928;29493099;29557506;30059200;30379171;30459171;30620550;31373491;31492838;31611695;31637018;31844290;32119511;32157095;32350084;32357974;32387766;32488085;32574038;32870666;32938616;32938750;32983136;33123756;33214551;33392160;33592498;33808029;33912179;33968037;34019948;34171305;34185709;34357683;34725712;35051231;35132862;35138101;35227760;35251023;35254053;35289036;35318648;35513511;35561310;35580925;35705054;35740950;36010968;36284347;37215989;37217939;37340703;37541260;37547758;37938771;38605154;38665916;38838015;39302247;39531497;39534244;40136647;40307207;40596516;8917469;8940160",
        "class_list": "",
        "function": "Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Enhancement of Zyxin Promotes Skin Fibrosis by Regulating FAK/PI3K/AKT and TGF-beta Signaling Pathways via Integrins. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of Zyxin in Non-Small Cell Lung Cancer-A Preliminary Study. Publication Status: Online-Only, [RefSeq, PubMed]; Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]., [RefSeq]; Zyxin is important for the stability and function of podocytes, especially during mechanical stretch. Publication Status: Online-Only, [RefSeq, PubMed]; Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 25,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 25,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 25,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 25,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 40,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 25,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D2G6;B4DQX7;Q6I9S4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton",
        "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0007267 cell-cell signaling;GO:0007160 cell-matrix adhesion;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0043149 stress fiber assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 14.6,
        "record_id": "Q15942-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NRZ9-1",
        "uniprot_id": "HELLS_HUMAN",
        "mass": 97074.0,
        "length": 838,
        "protein_name": "Lymphoid-specific helicase",
        "gene_name": "HELLS",
        "organism": "Human",
        "refseq_name": "lymphoid-specific helicase isoform 2",
        "refseq_ac": "NP_001275996",
        "gene_names_uniprotkb": "HELLS; Nbla10143; PASG; SMARCA6",
        "gene_names_refseq": "HELLS; ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6",
        "protein_names_uniprotkb": "Lymphoid-specific helicase; 3.6.4.-; LSH; Proliferation-associated SNF2-like protein; SMARCA6; SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6",
        "protein_names_refseq": "SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 6; Senescence Associated Long Non-coding RNA; lymphoid-specific helicase isoform 2; proliferation-associated SNF2-like protein",
        "tax_id": 9606,
        "disease": "immunodeficiency-centromeric instability-facial anomalies syndrome 4 (Disease Ontology:DOID:0090011); high grade glioma (Disease Ontology:DOID:3070)",
        "pathway": " (hsa:3070);  (R-HSA-9839394)",
        "pathway_count": 2,
        "publication_count": 109,
        "publication_id_list": "10.1101/2023.09.13.557529;10910076;11237011;12880961;15104674;15305370;17697703;18299279;18452278;18691976;19413330;19651622;20068231;21248752;22424782;22645359;22946062;23186163;23481700;24714562;24715725;25418920;25469497;25576301;25810538;25892735;26024233;26154972;26216346;26375851;26758079;26811146;26929215;26992070;27846572;27920218;28063628;28218747;28228285;28411811;28510447;28514659;28649982;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29769354;29786170;30307408;30315122;30410026;30429286;30467960;30484775;31217245;31409900;31802118;31844290;32001511;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32522876;32897882;32938616;32983136;32994405;33141586;33298915;33592498;33633747;33691108;33717175;33912179;33936100;33968037;34019948;34087483;34171305;34211107;34229054;34493821;34509645;34561969;35051231;35311456;35318648;35561310;35580925;35774795;36010968;36012581;36241641;37074911;37222488;37252915;37938771",
        "class_list": "",
        "function": "ATP-dependent chromatin remodeler that regulates chromatin accessibility, DNA methylation, and histone modifications. It facilitates de novo DNA methylation at repetitive sequences and promotes transcriptional silencing via recruitment of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs), contributing to heterochromatin formation and repression of transposable elements (PubMed:30307408). Also involved in DNA repair by recruiting DNA damage response mediators to double-strand breaks in heterochromatin, promoting homologous recombination via RBBP8/CtIP-dependent end resection (PubMed:22946062, PubMed:31802118). During meiosis, it is recruited by PRDM9 to recombination hotspots, aiding chromatin opening (PubMed:32001511). Through these diverse roles, is crucial for processes such as development, differentiation, and genomic stability (PubMed:22946062, PubMed:31802118). Involved in regulation of the expansion or survival of lymphoid cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Diagnostic, Prognostic, and Immunological Roles of HELLS in Pan-Cancer: A Bioinformatics Analysis. Publication Status: Online-Only, [RefSeq, PubMed]; Hsa_circ_0072008 regulates cell proliferation, migration, and invasion in cervical squamous cell carcinoma via miR-1305/helicase, lymphoid specific (HELLS) axis., [RefSeq, PubMed]; Lost in HELLS: Disentangling the mystery of SALNR existence in senescence cellular models. Publication Status: Online-Only, [RefSeq, PubMed]; Lymphoid-specific helicase in epigenetics, DNA repair and cancer. Review article, [RefSeq, PubMed]; The Chromatin Remodeler HELLS: A New Regulator in DNA Repair, Genome Maintenance, and Cancer. Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RB41;Q3LID1;Q6I7N7;Q76H76;Q76H77;Q76H78;Q76H79;Q76H80;Q76H81;Q7Z397;Q7Z5X2;Q8N6P4;Q9H4P5",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.3.1.48;2.3.1.-;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004386 helicase activity;GO:0140463 chromatin-protein adaptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0035861 site of double-strand break;GO:0005721 pericentric heterochromatin",
        "go_biological_process": "GO:0031508 pericentric heterochromatin formation;GO:0006351 DNA-templated transcription;GO:0051301 cell division;GO:0001822 kidney development;GO:0006302 double-strand break repair",
        "synthesized_glycan_count": 0,
        "hit_score": 12.0,
        "record_id": "Q9NRZ9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H501-1",
        "uniprot_id": "ESF1_HUMAN",
        "mass": 98796.0,
        "length": 851,
        "protein_name": "ESF1 homolog",
        "gene_name": "ESF1",
        "organism": "Human",
        "refseq_name": "ESF1 homolog",
        "refseq_ac": "NP_001263309",
        "gene_names_uniprotkb": "ESF1; ABTAP; C20orf6; HDCMC28P",
        "gene_names_refseq": "ABTAP; C20orf6; ESF1; HDCMC28P; bA526K24.1",
        "protein_names_uniprotkb": "ESF1 homolog; ABT1-associated protein",
        "protein_names_refseq": "ABT1-associated protein; ESF1 homolog; ESF1 nucleolar pre-rRNA processing protein homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51575)",
        "pathway_count": 1,
        "publication_count": 63,
        "publication_id_list": "11237011;15302935;15660422;16565220;17081983;17924679;18452278;18669648;19007248;19413330;19415658;19651622;19664995;19690332;19691289;20068231;21406692;22645359;23186163;24275569;24715725;25576301;26992070;27920218;28218747;28228285;28411811;28904123;29242379;29437277;29493099;29557506;30315122;30429286;30524438;30779550;30833945;31154438;31217245;31844290;32157095;32161166;32897882;32938616;33091337;33298915;33592498;33633747;33912179;33968037;33981976;34087483;34171305;34561969;34932366;35051231;35561310;35580925;36241641;36284347;36581221;37938771;38391939",
        "class_list": "",
        "function": "Human RPF1 and ESF1 in Pre-rRNA Processing and the Assembly of Pre-Ribosomal Particles: A Functional Study. Publication Status: Online-Only, [RefSeq, PubMed]; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity)., [UniProtKB]; The Rattus rattus ABT1-associated protein formed a complex with ABT1 and suppressed activation of Pol II-directed transcription in mammalian cells. It binds and negatively regulates ABT1., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 27,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86X92;Q9H9Q5;Q9HA35;Q9NX93;Q9P1S6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005730 nucleolus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006364 rRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "Q9H501-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96DN0-1",
        "uniprot_id": "ERP27_HUMAN",
        "mass": 30480.0,
        "length": 273,
        "protein_name": "Endoplasmic reticulum resident protein 27",
        "gene_name": "ERP27",
        "organism": "Human",
        "refseq_name": "endoplasmic reticulum resident protein 27 isoform 2",
        "refseq_ac": "NP_001287713",
        "gene_names_uniprotkb": "ERP27; C12orf46; PRO1575",
        "gene_names_refseq": "C12orf46; ERP27; PDIA8",
        "protein_names_uniprotkb": "Endoplasmic reticulum resident protein 27; ER protein 27; ERp27; Inactive protein disulfide-isomerase 27",
        "protein_names_refseq": "ER protein 27; endoplasmic reticulum protein 27 kDa; endoplasmic reticulum resident protein 27 isoform 2; endoplasmic reticulum resident protein 27; inactive protein disulfide-isomerase 27; protein disulfide isomerase family A, member 8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:121506)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "11237011;12975309;16940051;23192347;25418920;25880248;27862975;28832583;29242379;29557506;30429286;31844290;31848261;32983136;33912179;35051231;35318648;35580925;36284347",
        "class_list": "",
        "function": "ERp27 is able to distinguish between folded and unfolded substrates, only interacting with the latter and presenting them to for catalysis., [RefSeq, PubMed]; ERp27 is bound by ERp57 both in vitro and in vivo by a similar mechanism by which ERp57 binds calreticulin, [RefSeq, PubMed]; Specifically binds unfolded proteins and may recruit protein disulfide isomerase PDIA3 to unfolded substrates (PubMed:16940051, PubMed:23192347). Binds protein substrates via a hydrophobic pocket in the C-terminal domain (PubMed:16940051, PubMed:23192347). May play a role in the unfolded stress response (PubMed:23192347)., [UniProtKB, PubMed, PubMed]; This gene encodes a noncatalytic member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. The canonical protein has an N-terminal signal sequence, two thioredoxin (TRX)-like domains and a C-terminal ER-retention sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which lack domains present in the canonical protein. [provided by RefSeq, Dec 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen",
        "go_biological_process": "GO:0006457 protein folding;GO:0034976 response to endoplasmic reticulum stress;GO:0006986 response to unfolded protein",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q96DN0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NHP7-1",
        "uniprot_id": "EXD1_HUMAN",
        "mass": 58335.0,
        "length": 514,
        "protein_name": "piRNA biogenesis protein EXD1",
        "gene_name": "EXD1",
        "organism": "Human",
        "refseq_name": "piRNA biogenesis protein EXD1 isoform 1",
        "refseq_ac": "NP_001273370",
        "gene_names_uniprotkb": "EXD1; EXDL1",
        "gene_names_refseq": "EXD1; EXDL1",
        "protein_names_uniprotkb": "piRNA biogenesis protein EXD1; Exonuclease 3'-5' domain-containing protein 1; Exonuclease 3'-5' domain-like-containing protein 1; Inactive exonuclease EXD1",
        "protein_names_refseq": "exonuclease 3'-5' domain-containing protein 1; exonuclease 3'-5' domain-like-containing protein 1; inactive exonuclease EXD1; piRNA biogenesis protein EXD1 isoform 1; piRNA biogenesis protein EXD1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:161829)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "11237011;29557506;32983136;35051231",
        "class_list": "",
        "function": "RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity)., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K909;B7Z839;Q6ZW94",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0042803 protein homodimerization activity",
        "go_cellular_component": "GO:1990923 PET complex;GO:0043186 P granule",
        "go_biological_process": "GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0034587 piRNA processing;GO:0051321 meiotic cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q8NHP7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P08833-1",
        "uniprot_id": "IBP1_HUMAN",
        "mass": 27904.0,
        "length": 259,
        "protein_name": "Insulin-like growth factor-binding protein 1",
        "gene_name": "IGFBP1",
        "organism": "Human",
        "refseq_name": "insulin-like growth factor-binding protein 1 precursor",
        "refseq_ac": "NP_000587",
        "gene_names_uniprotkb": "IGFBP1; IBP1",
        "gene_names_refseq": "AFBP; IBP1; IGF-BP25; IGFBP1; PP12; hIGFBP-1",
        "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1; PP12; Placental protein 12",
        "protein_names_refseq": "IBP-1; IGF-binding protein 1; IGFBP-1; alpha-pregnancy-associated endometrial globulin; amniotic fluid binding protein; binding protein-25; binding protein-26; binding protein-28; growth hormone independent-binding protein; insulin-like growth factor-binding protein 1 precursor; placental protein 12",
        "tax_id": 9606,
        "disease": "diabetic angiopathy (Disease Ontology:DOID:11713); breast cancer (Disease Ontology:DOID:1612)",
        "pathway": " (hsa:3484);  (R-HSA-380994);  (R-HSA-381426);  (R-HSA-8957275);  (R-HSA-9615017)",
        "pathway_count": 5,
        "publication_count": 125,
        "publication_id_list": "10026136;10077652;10102273;10217147;10218588;10329650;10358014;10480625;10512690;10614670;10681634;10810289;10898936;10912521;10913147;10951195;10958673;10990447;11158056;11237011;11250653;11264294;11316783;11397844;11522292;11606061;11739083;11751371;11779849;11788658;12239572;12241545;12379487;12466191;12810533;12904166;1370451;1373120;1383255;14742429;15126567;15308688;15385533;15469690;15485880;15525596;15642270;15972819;16687408;16783365;16840535;16912112;16924115;16931790;16989641;17047378;1718783;17249697;17312271;17985932;18285520;18840095;19765076;20022965;20361218;21536589;21852217;21892205;22802018;22819556;22978410;23269699;24028821;24040102;24275569;2454104;2457513;2458522;2461294;2466665;2474129;2476804;2479552;26091039;2663993;2664463;27547294;2849945;29413899;2971653;32161166;3260265;33091337;33968037;34171305;3419931;35051231;38174331;38246959;38627562;38759370;39126767;7504269;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7678248;7679979;7683646;7689487;8781553;8817670;8894645;8964575;9497324;9709957;9733769;9786878;9922210",
        "class_list": "",
        "function": "Elevated serum IGFBP-1 levels correlate with cognitive deficits in treatment-resistant and chronic medicated schizophrenia patients., [RefSeq, PubMed]; IGFBP1 stabilizes Umod expression through m6A modification to inhibit the occurrence and development of cystitis by blocking NF-kappaB and ERK signaling pathways., [RefSeq, PubMed]; Insulin-like growth factor binding protein-1 and insulin in polycystic ovary syndrome: a systematic review and meta-analysis. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner (PubMed:11397844, PubMed:15972819). Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif (PubMed:7504269). Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:11397844). Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes., [RefSeq, PubMed]; Serum IGFBP-1 as a promising diagnostic and prognostic biomarker for colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 13,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D2F4;D3DVL9;Q8IYP5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005520 insulin-like growth factor binding;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen",
        "go_biological_process": "GO:0007165 signal transduction;GO:0030307 positive regulation of cell growth;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0008286 insulin receptor signaling pathway;GO:0042246 tissue regeneration",
        "synthesized_glycan_count": 0,
        "hit_score": 12.6,
        "record_id": "P08833-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BTK6-1",
        "uniprot_id": "PAGR1_HUMAN",
        "mass": 27716.0,
        "length": 254,
        "protein_name": "PAXIP1-associated glutamate-rich protein 1",
        "gene_name": "PAGR1",
        "organism": "Human",
        "refseq_name": "PAXIP1-associated glutamate-rich protein 1",
        "refseq_ac": "NP_078792",
        "gene_names_uniprotkb": "PAGR1; C16orf53; PA1",
        "gene_names_refseq": "C16orf53; GAS; PA1; PAGR1",
        "protein_names_uniprotkb": "PAXIP1-associated glutamate-rich protein 1; GAS; Glutamate-rich coactivator interacting with SRC1; PAXIP1-associated protein 1; PTIP-associated protein 1",
        "protein_names_refseq": "PAXIP1-associated glutamate-rich protein 1; PAXIP1-associated protein 1; PTIP-associated 1 protein; PTIP-associated protein 1; glutamate-rich coactivator associated with SRC1; glutamate-rich coactivator interacting with SRC1/NCOA1",
        "tax_id": 9606,
        "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)",
        "pathway": " (hsa:79447);  (R-HSA-5617472);  (R-HSA-9772755);  (R-HSA-9818564);  (R-HSA-9841922)",
        "pathway_count": 5,
        "publication_count": 148,
        "publication_id_list": "10425206;10558993;10777502;10835357;10882139;11027271;12393701;12482972;12670868;12829629;1310260;14636557;14992727;15199122;15867264;16079151;16227571;16239140;16380219;16549775;16829959;16878130;16892064;17185360;17287340;17322306;17355966;17428788;17500065;1756725;17612494;17660710;17671196;17693683;17713478;17761849;17761950;17851529;17925232;17998332;18452278;18598942;18669648;18781158;18829457;18829459;18838386;18838538;19039327;19043829;19103755;19115252;19124460;19172745;19187761;19232136;19415658;19556245;19651622;19664994;19664995;19747919;1975088;19782034;19854132;20018852;20068231;20085832;20230923;20575550;20716525;20961854;21106533;21124902;21131905;21135039;21220120;22266653;22327296;22569366;22652693;22665483;22705304;22879880;23161582;23219899;23508102;23534758;23630040;23995757;24174538;24244196;24260416;24312487;24368734;24586203;24680668;25101834;25135475;25418920;25561738;25576301;25593305;2570724;25913784;26324722;26886794;27563068;27698142;27760318;28063628;28182322;28398509;29138278;29242379;29632046;29897600;29937342;30429286;31373491;31400120;31485071;31544921;33329381;33592498;33657400;34012049;34933446;35033534;35190547;35439434;35580925;36240223;7488013;7501971;7831296;7906964;7908827;8521497;8521498;8674428;8759021;9065481;9171241;9218805;9272954;9482740;9744270",
        "class_list": "",
        "function": "GAS is a new transcription cofactor, [RefSeq, PubMed]; Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; PA1 (C16orf53) binds PTIP directly and requires PTIP for interaction with the MLL3- and MLL4-containing histone H3 K4 methyltransferase complex., [RefSeq, PubMed]; PA1 is a new competitive decelerator of GR transactivation and can act at more than one molecularly defined step in a manner that depends upon the specific gene, [RefSeq, PubMed]; PTIP associated protein 1, PA1, is an independent prognostic factor for lymphnode negative breast cancer. GeneRIF: PA1 expression was observed in both nucleus (mainly)and cytoplasm from breast cancer tissue samples. PA1 nuclear expression was correlated with postmenopausal, smaller tumor size, negative Ki67, positive AR and positive ERbeta. PA1 nuclear positive cases seemed to have a longer survival than negative ones for RFS. For those patients without lymphnode metastasis PA1 was found to be an independent prognostic factor for RFS. Publication Status: Online-Only, [RefSeq, PubMed]; Subset of PTIP.PA1 complex is recruited to DNA damage sites via the RNF8-dependent pathway and is required for cell survival in response to DNA damage., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2ICR6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030331 nuclear estrogen receptor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035097 histone methyltransferase complex;GO:0044666 MLL3/4 complex",
        "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 15.4,
        "record_id": "Q9BTK6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P20265-1",
        "uniprot_id": "PO3F2_HUMAN",
        "mass": 46893.0,
        "length": 443,
        "protein_name": "POU domain, class 3, transcription factor 2",
        "gene_name": "POU3F2",
        "organism": "Human",
        "refseq_name": "POU domain, class 3, transcription factor 2",
        "refseq_ac": "NP_005595",
        "gene_names_uniprotkb": "POU3F2; BRN2; OCT7; OTF7",
        "gene_names_refseq": "BRN2; N-Oct3; OCT7; OTF-7; OTF7; POU3F2; POUF3; brn-2; oct-7",
        "protein_names_uniprotkb": "POU domain, class 3, transcription factor 2; Brain-2; Brain-specific homeobox/POU domain protein 2; Brn-2; Nervous system-specific octamer-binding transcription factor N-Oct-3; OTF-7; Oct-7; Octamer-binding protein 7; Octamer-binding transcription factor 7",
        "protein_names_refseq": "POU domain, class 3, transcription factor 2; brain-2; brain-specific homeobox/POU domain protein 2; nervous system-specific octamer-binding transcription factor N-Oct-3; octamer-binding protein 7; octamer-binding transcription factor 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5454);  (R-HSA-9619665);  (R-HSA-9824594);  (R-HSA-9856649)",
        "pathway_count": 4,
        "publication_count": 160,
        "publication_id_list": "10203854;10220111;10332029;10400691;10567402;10611221;10655586;10673502;10727776;10757804;10856243;11027551;11115854;11133365;11157804;11356866;11394999;11430795;11430802;11734543;11782409;11840323;11891324;11912130;11930005;12056842;12145339;12198163;12782656;12799134;14512514;14522948;14664827;14744763;14975237;15118077;15150276;15189448;15226305;15356632;15507434;15610069;15695336;15836632;15907797;16014379;16034366;16136673;16311519;16319321;16373334;16822840;16923174;1698554;1704008;17325040;1748288;17543985;17623675;17699610;17959798;18327259;18634568;18644867;18803322;19143832;19156870;19321787;19413330;19524539;19608861;19690332;19745155;1975954;19922439;20149798;20213556;20460180;20625412;20832498;21044070;21326363;21411665;21423190;21423191;21486943;21613327;21653862;21965087;22053691;22180461;22333914;22492709;22647378;22764250;22814607;23159739;23190890;23207919;23695165;23747866;23874858;24191038;24227709;24646194;24675079;25142731;25248477;25595898;25974668;26423937;26441514;27128622;27220739;27288457;2739723;27859941;28394346;28852375;29295999;29748249;30804224;31844290;32488085;32636443;33744299;34140478;36843258;37207645;37770430;38201271;38386071;5338216;7651733;7925941;7935840;7958932;8138712;8336698;8349731;8441633;8619637;8627307;8647822;8662541;8842374;9199364;9353119;9418958;9440696;9482253;9537257;9560246;9676189;9705348;9748295;9760192;9806836;9858769;9973413",
        "class_list": "",
        "function": "CREB1 Facilitates GABAergic Neural Differentiation of Human Mesenchymal Stem Cells through BRN2 for Pain Alleviation and Locomotion Recovery after Spinal Cord Injury. Publication Status: Online-Only, [RefSeq, PubMed]; Integrin alpha3 Mediates Stemness and Invasion of Glioblastoma by Regulating POU3F2., [RefSeq, PubMed]; Monoallelic intragenic POU3F2 variants lead to neurodevelopmental delay and hyperphagic obesity, confirming the gene's candidacy in 6q16.1 deletions., [RefSeq, PubMed]; RFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]., [RefSeq]; Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14960;Q86V54;Q9UJL0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0008284 positive regulation of cell population proliferation;GO:0010629 negative regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 16.1,
        "record_id": "P20265-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96D59-1",
        "uniprot_id": "RN183_HUMAN",
        "mass": 21617.0,
        "length": 192,
        "protein_name": "E3 ubiquitin-protein ligase RNF183",
        "gene_name": "RNF183",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase RNF183",
        "refseq_ac": "NP_659488",
        "gene_names_uniprotkb": "RNF183",
        "gene_names_refseq": "RNF183",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF183; 2.3.2.27",
        "protein_names_refseq": "E3 ubiquitin-protein ligase RNF183; probable E3 ubiquitin-protein ligase RNF183",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:138065)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "26567849;26818663;28756770;28796265;29300766;29507230;32486221;35121737;37258572",
        "class_list": "",
        "function": "Acts as an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29507230). Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (PubMed:29507230). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849). Mediates the ubiquitination and subsequent lysosomal degradation of ATP1B1 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Cathepsin D as a potential therapeutic target to enhance anticancer drug-induced apoptosis via RNF183-mediated destabilization of Bcl-xL in cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; RNF183 promotes proliferation and metastasis of colorectal cancer cells via activation of NF-kappaB-IL-8 axis Publication Status: Online-Only, [RefSeq, PubMed]; RNF183, which is negatively regulated by miR-7, is a novel regulator promoting intestinal inflammation by increasing the ubiquitination and degradation of IkappaBalpha, thereby inducing NF-kappaB activation. The interaction between RNF183-mediated ubiquitination and miRNA may be an important novel epigenetic mechanism in the pathogenesis of inflammatory bowel disease., [RefSeq, PubMed]; Sec16A also stabilized the interacting ubiquitin ligase RNF152, which localizes to the lysosome and has structural similarity with RNF183 Publication Status: Online-Only, [RefSeq, PubMed]; The RNF183-IL-8 axis is responsible for the resistance of colorectal cancer (CRC)cells to the MEK1/2 inhibitor trametinib and may serve as a candidate target for combined therapy for CRC. Publication Status: Online-Only, [RefSeq, PubMed]; The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0033106 cis-Golgi network membrane",
        "go_biological_process": "GO:0006915 apoptotic process;GO:0016567 protein ubiquitination;GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:0000209 protein polyubiquitination;GO:0051865 protein autoubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q96D59-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y3Z3-1",
        "uniprot_id": "SAMH1_HUMAN",
        "mass": 72201.0,
        "length": 626,
        "protein_name": "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1",
        "gene_name": "SAMHD1",
        "organism": "Human",
        "refseq_name": "deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform 1",
        "refseq_ac": "NP_056289",
        "gene_names_uniprotkb": "SAMHD1; MOP5",
        "gene_names_refseq": "CHBL2; DCIP; HDDC1; MOP-5; SAMHD1; SBBI88; hSAMHD1",
        "protein_names_uniprotkb": "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; 3.1.5.-; DCIP; Dendritic cell-derived IFNG-induced protein; MOP-5; Monocyte protein 5; SAM domain and HD domain-containing protein 1; dNTPase; hSAMHD1",
        "protein_names_refseq": "SAM domain and HD domain 1; SAM domain and HD domain-containing protein 1; dNTPase; dendritic cell-derived IFNG-induced protein; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform 1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1; monocyte protein 5",
        "tax_id": 9606,
        "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629); Chilblain lupus (Disease Ontology:DOID:0060386); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); acute myeloid leukemia (Disease Ontology:DOID:9119)",
        "pathway": " (hsa:25939);  (R-HSA-8956319);  (R-HSA-909733)",
        "pathway_count": 3,
        "publication_count": 208,
        "publication_id_list": "10395669;10542297;10982844;11064105;11092454;11230166;11237011;11337497;11377645;11404376;11585831;12029096;12766484;12842042;14769151;15047845;15312780;15449939;15778442;16009940;16171819;16987978;17081983;17251292;1730654;17351669;17969444;18035202;18546154;18575461;18669648;18691976;19369195;19413330;19525956;19651622;19664994;20068231;20130243;20131292;20166139;20363976;20643137;20842748;21204240;21613998;21720370;22056990;22069334;2211721;23061660;23092512;23121362;23186163;23301498;23364794;23426366;23601106;23602554;23783831;23858451;24035396;24141705;24183309;24217394;24275569;24336198;24417533;24445253;24623419;24714562;25038827;25158827;25267621;25288794;25371710;25576301;25645385;25760601;25847232;25880248;26101257;26121641;26154972;26294762;26431200;26851491;26923586;26992070;27229711;27397612;27452731;27477283;27482511;27511536;27815502;27862975;27920218;28228285;28229507;28321930;28510447;28514659;28649982;28793904;28832583;28834231;28834754;28871089;28904123;29084722;29242379;29321329;29351928;29379009;29493099;29515139;29557506;29587790;29610582;29670289;29698322;29786170;29884836;30039733;30044979;30104243;30315122;30429286;30485383;30833945;31154438;31291580;31375673;31530632;31548682;31797533;31844290;31848261;31950591;32032529;32113509;32157095;32209460;32357974;32387766;32488085;32502341;32511913;32574262;32661006;32758689;32862111;32938616;32983136;33043033;33117408;33123756;33141586;33189161;33193462;33391506;33392160;33396578;33592498;33912179;33968037;33981976;34019948;34171305;34185709;34229054;34321470;34509645;34513928;34932366;35051231;35318648;35561310;35580925;35801923;36284347;36309692;37938771;38041217;38367301;38665916;39162568;39394602;6162102;6548414;688397;7510216;7526154;7537377;7540766;8197134;8232552;8605876;8621447;8702790;9096384;9121453;9242679;9334213;9660177;9847332;9861020",
        "class_list": "",
        "function": "Acetylation of SAMHD1 at lysine 580 is crucial for blocking HIV-1 infection., [RefSeq, PubMed]; Deciphering the role of SAMHD1 in endometrial cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:26294762, PubMed:26431200, PubMed:28229507, PubMed:28834754, PubMed:29670289). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23364794, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:25038827, PubMed:26101257, PubMed:26294762, PubMed:26431200, PubMed:28229507). Likewise, suppresses LINE-1 retrotransposon activity (PubMed:24035396, PubMed:24217394, PubMed:29610582). Not able to restrict infection by HIV-2 virus; because restriction activity is counteracted by HIV-2 viral protein Vpx (PubMed:21613998, PubMed:21720370). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (PubMed:23858451). Phosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (PubMed:23601106, PubMed:23602554, PubMed:29610582, PubMed:29670289). Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (PubMed:29670289). Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (PubMed:27477283, PubMed:29670289). Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (PubMed:29670289). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; SAMHD1 compound heterozygous rare variants associated with moyamoya and mitral valve disease in the absence of other features of Aicardi-Goutieres syndrome., [RefSeq, PubMed]; SAMHD1 dysfunction induces IL-34 expression via NF-kappaB p65 in neuronal SH-SY5Y cells., [RefSeq, PubMed]; SAMHD1 mediates TNF-alpha stimulation of lung fibroblasts., [RefSeq, PubMed]; Study describes mutations in SAMHD1 as the cause of Aicardi-Goutieres syndrome (AGS) at the AGS5 locus and present data to show that SAMHD1 may act as a negative regulator of the cell-intrinsic antiviral response., [RefSeq, PubMed]; This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 55,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E2A5;E1P5V2;Q5JXG8;Q8N491;Q9H004;Q9H005;Q9H3U9",
        "ec_number_list": "2.7.7.84;2.7.10.2;2.7.11.1;3.4.25.1;3.6.5.-;3.5.4.37;3.1.26.-;4.2.-.-;3.1.13.1;2.7.-.-;2.7.4.-;3.1.5.-",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0004540 RNA nuclease activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0097197 tetraspanin-enriched microdomain;GO:0035861 site of double-strand break;GO:0005694 chromosome",
        "go_biological_process": "GO:0006955 immune response;GO:0045087 innate immune response;GO:0051289 protein homotetramerization;GO:0051607 defense response to virus;GO:0006203 dGTP catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 21.4,
        "record_id": "Q9Y3Z3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96NL1-1",
        "uniprot_id": "TMM74_HUMAN",
        "mass": 33338.0,
        "length": 305,
        "protein_name": "Transmembrane protein 74",
        "gene_name": "TMEM74",
        "organism": "Human",
        "refseq_name": "transmembrane protein 74",
        "refseq_ac": "NP_694560",
        "gene_names_uniprotkb": "TMEM74",
        "gene_names_refseq": "NET36; TMEM74",
        "protein_names_uniprotkb": "Transmembrane protein 74",
        "protein_names_refseq": "transmembrane protein 74",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:157753)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "18294959;19029833;28412412;28832583;29048433;29242379;29629952;34132174",
        "class_list": "",
        "function": "Genome-wide association study detected novel susceptibility genes for social cognition impairment in people with schizophrenia., [RefSeq, PubMed]; Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction., [UniProtKB, PubMed, PubMed]; TMEM74 promotes tumor cell survival by inducing autophagy via interactions with ATG16L1 and ATG9A. Publication Status: Online-Only, [RefSeq, PubMed]; The results revealed the autophagy modulator TMEM74 interrelates with apoptosis inducer BIK and inhibits its function., [RefSeq, PubMed]; The results suggested that TMEM74 acts as an oncogene and a potential diagnostic marker and a therapeutic target for liver cancer and lung cancer., [RefSeq, PubMed]; These findings demonstrate that TMEM74 may be involved in promoting functional autophagy during cell starvation and other stress conditions., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0044325 transmembrane transporter binding",
        "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031410 cytoplasmic vesicle",
        "go_biological_process": "GO:0016236 macroautophagy",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q96NL1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BQ69-1",
        "uniprot_id": "MACD1_HUMAN",
        "mass": 35505.0,
        "length": 325,
        "protein_name": "ADP-ribose glycohydrolase MACROD1",
        "gene_name": "MACROD1",
        "organism": "Human",
        "refseq_name": "ADP-ribose glycohydrolase MACROD1 isoform 1",
        "refseq_ac": "NP_054786",
        "gene_names_uniprotkb": "MACROD1; LRP16",
        "gene_names_refseq": "LRP16; MACROD1",
        "protein_names_uniprotkb": "ADP-ribose glycohydrolase MACROD1; 3.1.1.106; 3.2.2.-; MACRO domain-containing protein 1; O-acetyl-ADP-ribose deacetylase MACROD1; Protein LRP16; [Protein ADP-ribosylaspartate] hydrolase MACROD1; [Protein ADP-ribosylglutamate] hydrolase MACROD1",
        "protein_names_refseq": "ADP-ribose glycohydrolase MACROD1 isoform 1; ADP-ribose glycohydrolase MACROD1; MACRO domain containing 1; MACRO domain-containing protein 1; O-acetyl-ADP-ribose deacetylase MACROD1; [Protein ADP-ribosylaspartate] hydrolase MACROD1; [Protein ADP-ribosylglutamate] hydrolase MACROD1; [Protein ADP-ribosylglutamate] hydrolase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:28992)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "10.1074/mcp.M114.046862;11237011;12578638;12790785;15691879;17532767;17893710;17914104;19022849;19403568;21257746;23301498;23474712;23474714;24715725;25813380;26992070;28510447;30484775;31599159;32427867;32683309;32938616;35051231;36215666",
        "class_list": "",
        "function": "Comparative analysis of MACROD1, MACROD2 and TARG1 expression, localisation and interactome. Publication Status: Online-Only, [RefSeq, PubMed]; ERalpha and Sp1 play a role in activation of the promoter, [RefSeq, PubMed]; Molecular basis for the MacroD1-mediated hydrolysis of ADP-ribosylation., [RefSeq, PubMed]; Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474712, PubMed:23474714). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474712, PubMed:23474714). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). Plays a role in estrogen signaling (PubMed:17893710, PubMed:17914104, PubMed:19403568). Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (PubMed:19022849). May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (PubMed:17893710, PubMed:17914104). Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction (PubMed:17914104). Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells (PubMed:17893710). Enhances ESR1-mediated transcription activity (PubMed:17914104)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UH96",
        "ec_number_list": "3.5.1.-;3.2.2.-;3.2.2.19;3.1.1.106;3.2.1.143",
        "go_molecular_function": "GO:0019213 deacetylase activity;GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0061463 O-acetyl-ADP-ribose deacetylase activity;GO:0140293 ADP-ribosylglutamate hydrolase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion",
        "go_biological_process": "GO:0006974 DNA damage response;GO:0051725 protein de-ADP-ribosylation;GO:0042278 purine nucleoside metabolic process;GO:0140291 peptidyl-glutamate ADP-deribosylation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "Q9BQ69-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P60763-1",
        "uniprot_id": "RAC3_HUMAN",
        "mass": 21379.0,
        "length": 192,
        "protein_name": "Ras-related C3 botulinum toxin substrate 3",
        "gene_name": "RAC3",
        "organism": "Human",
        "refseq_name": "ras-related C3 botulinum toxin substrate 3 isoform 1",
        "refseq_ac": "NP_005043",
        "gene_names_uniprotkb": "RAC3",
        "gene_names_refseq": "RAC3",
        "protein_names_uniprotkb": "Ras-related C3 botulinum toxin substrate 3; 3.6.5.2; p21-Rac3",
        "protein_names_refseq": "p21-Rac3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3); ras-related C3 botulinum toxin substrate 3 isoform 1; rho family, small GTP binding protein Rac3",
        "tax_id": 9606,
        "disease": "autosomal dominant intellectual developmental disorder 48 (Disease Ontology:DOID:0080235); alcohol use disorder (Disease Ontology:DOID:1574); kidney disease (Disease Ontology:DOID:557); neurodevelopmental disorder with structural brain anomalies and dysmorphic facies (MONDO:MONDO:0032820)",
        "pathway": " (hsa:5881);  (R-HSA-4086400);  (R-HSA-9013423)",
        "pathway_count": 3,
        "publication_count": 112,
        "publication_id_list": "10618392;10698942;10862746;11101902;11237011;11358862;11704860;11751577;11756406;11779461;11956649;12015986;12134165;12533515;12839624;14636582;14675773;15107133;15143170;15169958;15501440;15608632;15936275;16116452;16280981;16495441;16602827;16723543;16777452;16971168;16982419;17021034;17130287;17373907;17433286;17627283;17765681;18162551;18215320;18256687;18697831;18719708;18798527;19269969;19365405;19523939;19530173;19534724;19589360;20004982;20006983;20803696;20940229;21316585;22773843;23109420;23140633;23144463;23255595;23396967;23821037;24141704;24397554;24684802;24715725;25862245;26628301;26811146;27481945;27713499;27846572;28356423;28904123;29276006;30293988;30315122;30779550;31222486;31844290;31848261;31871319;32157095;32357974;32387766;32488085;32897882;32938616;32983136;33298915;33592498;33912179;33936100;33968037;34087483;34171305;34509645;34561969;35051231;35580925;35851598;35917927;36010968;36241641;36284347;37310098;37938771;38847477;39376007;9252344;9674432;9716412;9852280",
        "class_list": "",
        "function": "Establishment of a prognostic model to predict chemotherapy response and identification of RAC3 as a chemotherapeutic target in bladder cancer., [RefSeq, PubMed]; Hypomethylated gene RAC3 induces cell proliferation and invasion by increasing FASN expression in endometrial cancer., [RefSeq, PubMed]; KLF1 Activates RAC3 to Mediate Fatty Acid Synthesis and Enhance Cisplatin Resistance in Bladder Cancer Cells., [RefSeq, PubMed]; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner., [UniProtKB, PubMed, PubMed]; The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]., [RefSeq]; Unveiling the role of RAC3 in the growth and invasion of cisplatin-resistant bladder cancer cells., [RefSeq, PubMed]; Variant-specific changes in RAC3 function disrupt corticogenesis in neurodevelopmental phenotypes., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O14658;Q5U0M8",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;2.3.1.-;3.6.1.5;2.7.11.1;1.6.3.-;2.7.10.1;3.6.1.-;2.7.10.2;3.6.5.4;3.1.3.86;3.1.3.56;3.1.3.36;1.3.1.70;3.6.-.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0048306 calcium-dependent protein binding;GO:0003925 G protein activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030027 lamellipodium",
        "go_biological_process": "GO:0007015 actin filament organization;GO:0032956 regulation of actin cytoskeleton organization;GO:0035556 intracellular signal transduction;GO:0030036 actin cytoskeleton organization;GO:0033630 positive regulation of cell adhesion mediated by integrin",
        "synthesized_glycan_count": 0,
        "hit_score": 11.4,
        "record_id": "P60763-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IZ57-1",
        "uniprot_id": "NRSN1_HUMAN",
        "mass": 21475.0,
        "length": 195,
        "protein_name": "Neurensin-1",
        "gene_name": "NRSN1",
        "organism": "Human",
        "refseq_name": "neurensin-1",
        "refseq_ac": "NP_542454",
        "gene_names_uniprotkb": "NRSN1; VMP",
        "gene_names_refseq": "NRSN1; VMP; p24",
        "protein_names_uniprotkb": "Neurensin-1; Neuro-p24; Vesicular membrane protein of 24 kDa; Vesicular membrane protein p24",
        "protein_names_refseq": "neurensin-1; neuro-p24; vesicular membrain protein p24; vesicular membrane protein of 24 kDa; vesicular membrane protein p24",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:140767)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11237011;12463420;20807314;29654647;32037595;38610086",
        "class_list": "",
        "function": "Cloning, expression and characterization of VMP gene., [RefSeq, PubMed]; Developmental dyslexia susceptibility genes DNAAF4, DCDC2, and NRSN1 are associated with brain function in fluently reading adolescents and young adults., [RefSeq, PubMed]; Dilysine retrieval signal-containing p24 proteins, p24alpha(2) and p24delta(1), bind with gamma-secretase complexes and collaborate in attenuating gamma-cleavage of beta-amyloid precursor protein, [RefSeq, PubMed]; GAL, GAP43 and NRSN1 single nucleotide polymorphisms and related gene-gene interaction networks might be involved in the altered susceptibility to Hirschsprung disease in the Han Chinese population., [RefSeq, PubMed]; May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension. May play a role in memory consolidation (By similarity)., [UniProtKB, UniProtKB, PubMed]; Neuregulin-1 promotes mitochondrial biogenesis, attenuates mitochondrial dysfunction, and prevents hypoxia/reoxygenation injury in neonatal cardiomyocytes., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RAV4;Q8N8R6;Q96P21",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane;GO:0030426 growth cone;GO:0043025 neuronal cell body;GO:0031410 cytoplasmic vesicle;GO:0043005 neuron projection",
        "go_biological_process": "GO:0007399 nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q8IZ57-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UIQ6-1",
        "uniprot_id": "LCAP_HUMAN",
        "mass": 117349.0,
        "length": 1025,
        "protein_name": "Leucyl-cystinyl aminopeptidase",
        "gene_name": "LNPEP",
        "organism": "Human",
        "refseq_name": "leucyl-cystinyl aminopeptidase isoform 1",
        "refseq_ac": "NP_005566",
        "gene_names_uniprotkb": "LNPEP; OTASE",
        "gene_names_refseq": "CAP; IRAP; LNPEP; P-LAP; PLAP",
        "protein_names_uniprotkb": "Leucyl-cystinyl aminopeptidase; 3.4.11.3; Cystinyl aminopeptidase; IRAP; Insulin-regulated membrane aminopeptidase; Insulin-responsive aminopeptidase; OTase; Oxytocinase; P-LAP; Placental leucine aminopeptidase",
        "protein_names_refseq": "AT (4) receptor; angiotensin IV receptor; insulin-regulated aminopeptidase; insulin-regulated membrane aminopeptidase; insulin-responsive aminopeptidase; leucyl-cystinyl aminopeptidase isoform 1; leucyl-cystinyl aminopeptidase; otase; oxytocinase; placental leucine aminopeptidase; vasopressinase",
        "tax_id": 9606,
        "disease": "leiomyoma (Disease Ontology:DOID:127); severe pre-eclampsia (Disease Ontology:DOID:13129); breast cancer (Disease Ontology:DOID:1612); renal cell carcinoma (Disease Ontology:DOID:4450); polyhydramnios (Disease Ontology:DOID:8488); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:4012);  (R-HSA-1236977);  (R-HSA-1445148);  (R-HSA-983168)",
        "pathway_count": 4,
        "publication_count": 164,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10468607;10759854;11062501;11247303;11350924;11389728;11707427;12646216;14734113;15224091;15224092;15565337;15571818;15919790;15971998;16115862;16595681;16849449;16880201;16954532;1731608;17369524;17995453;18268517;18507432;18662542;18669648;18802471;19013499;19028597;19252894;19349973;19352404;19452197;19489725;19498108;19851334;19874575;19901323;19918052;19940261;20631154;20701589;20837646;20937701;21454505;21454690;21907143;22299025;2261476;23090970;23186163;23584533;24190977;24275569;24714562;24715725;25502872;2550440;25505266;25576301;25645385;25880248;25892735;26154972;26758079;26992070;27397612;27600516;27846572;27920218;28218747;28228285;28328206;28467828;28514659;28649982;28832583;28871256;28904123;29242379;29314611;29317506;29331515;29393594;29437277;29508533;29557506;29632046;29632711;29741879;29769354;29786170;30315122;30410026;30429286;30524438;30573663;30581499;30626607;30779550;31020640;31092671;31154438;31217245;31611695;31844290;31998317;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32619880;32938616;32983136;33043033;33091337;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34171305;34211107;34357683;34433824;34509645;34561969;34932366;35051231;35154160;35251023;35289036;35561310;35580925;36010968;36215666;36241641;36284347;36581221;36716917;37074911;37340703;40914422;8094051;8119729;8550619;8664345;9177475;9380723;9668046",
        "class_list": "",
        "function": "Cell-Specific and Variant-Linked Alterations in Expression of ERAP1, ERAP2, and LNPEP Aminopeptidases in Psoriasis., [RefSeq, PubMed]; LNPEP expression in the left atrium in mitral regurgitation patients significantly differed from those in aortic valve disease patients and normal controls. Publication Status: Online-Only, [RefSeq, PubMed]; Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain., [UniProtKB, PubMed, PubMed, PubMed]; The role of LNPEP and ANPEP gene polymorphisms in the pathogenesis of pre-eclampsia., [RefSeq, PubMed]; This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]; This study describes a crystal structure of insulin-regulated aminopeptidase in complex with a recently developed bioactive and selective inhibitor at 2.53 A resolution., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 18,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 13,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 18,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 18,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 9,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 54,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 65,
        "disease_count": 6,
        "glyco_site_count": 23,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O00769;Q15145;Q59H76;Q9TNQ2;Q9TNQ3;Q9UIQ7",
        "ec_number_list": "3.4.14.10;2.7.11.1;3.6.5.2;3.4.11.-;3.4.11.14;3.4.22.40;3.4.11.3",
        "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0070006 metalloaminopeptidase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0006508 proteolysis;GO:0007267 cell-cell signaling;GO:0008217 regulation of blood pressure;GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0007565 female pregnancy",
        "synthesized_glycan_count": 0,
        "hit_score": 25.1,
        "record_id": "Q9UIQ6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15287-1",
        "uniprot_id": "FANCG_HUMAN",
        "mass": 68554.0,
        "length": 622,
        "protein_name": "Fanconi anemia group G protein",
        "gene_name": "FANCG",
        "organism": "Human",
        "refseq_name": "Fanconi anemia group G protein",
        "refseq_ac": "NP_004620",
        "gene_names_uniprotkb": "FANCG; XRCC9",
        "gene_names_refseq": "FAG; FANCG; XRCC9",
        "protein_names_uniprotkb": "Fanconi anemia group G protein; DNA repair protein XRCC9; Protein FACG",
        "protein_names_refseq": "DNA repair protein XRCC9; Fanconi anemia complementation group G; Fanconi anemia group G protein; X-ray repair complementing defective repair in Chinese hamster cells 9; X-ray repair, complementing defective, in Chinese hamster, 9",
        "tax_id": 9606,
        "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); Fanconi anemia complementation group G (Disease Ontology:DOID:0111086); Fanconi anemia (Disease Ontology:DOID:13636); pancreatic cancer (Disease Ontology:DOID:1793)",
        "pathway": " (hsa:2189);  (R-HSA-6783310);  (R-HSA-9833482)",
        "pathway_count": 3,
        "publication_count": 227,
        "publication_id_list": "10082513;10348343;10373536;10400669;10620360;10626894;10648614;10848580;10866685;11093276;11096080;11134010;11152499;11156368;11237011;11238103;11238927;11239454;11278865;11313968;11337501;11350938;11438540;11500375;11781817;11909525;11939789;11985496;12231563;12397061;12724401;12882984;1373135;14585331;15229216;15299017;15299030;15367677;15502827;15572677;15737233;15752359;15907845;16116422;16179258;16179259;16195237;16373505;16431927;16600570;16643430;16717090;16916645;16943440;1695551;16959974;16982605;17079286;17196820;17289582;17412408;17460694;17938197;18082604;18096616;18174376;18212739;18550849;18835251;18931676;18957415;19111657;19229320;19416861;19561358;19589784;19596236;19710021;19733181;19804757;19838063;19995904;20102227;20347428;20347429;20385554;20395957;20450923;20519500;20603015;20603016;20603073;20670894;20671156;20685959;21072047;21123651;21294215;21464321;21518807;21636578;21701511;21764741;21937648;21978664;21994559;22214662;22258451;22266823;22287633;22343915;22396592;2247437;22510687;22692201;22705371;22986343;23084476;23229543;23325218;23481700;23698467;23723247;23732991;24076221;24347309;24389026;24623135;24623813;24659800;24715725;24726325;24753571;24905007;25430771;25500724;25576301;25653431;25848059;26432638;26446704;26488609;26716879;26817845;26992070;27208315;27269119;27423063;27846572;27974558;28069888;28167698;28281686;28765891;28904123;29170442;29175459;29231267;29348664;29394925;29395325;29440070;29501855;29557506;30174290;30315122;30770398;30779550;31031002;31844290;31937595;32093270;32387766;32502341;32716602;32801355;32938616;33141586;33298915;33392160;33808629;33911136;33936100;33968037;34087483;34174402;34405274;34509645;34864095;34932366;34974812;35051231;35580925;35685460;35947956;36010968;36215666;36241641;36581221;36712380;37127961;38253038;39149814;7491766;7515177;7545299;7565688;7693978;7737357;7903669;8576172;8576179;8661426;8810342;8910500;9034343;9079663;9242535;9256465;9442054;9521856;9528799;9687506;9737981;9806548;9819388;9920933",
        "class_list": "",
        "function": "A comprehensive study evaluating germline FANCG variants in predisposition to breast and ovarian cancer., [RefSeq, PubMed]; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In silico study of missense variants of FANCA, FANCC and FANCG genes reveals high risk deleterious alleles predisposing to Fanconi anemia pathogenesis., [RefSeq, PubMed]; The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003684 damaged DNA binding",
        "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0007005 mitochondrion organization;GO:0036297 interstrand cross-link repair",
        "synthesized_glycan_count": 0,
        "hit_score": 23.0,
        "record_id": "O15287-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A6NFH5-1",
        "uniprot_id": "FBP12_HUMAN",
        "mass": 15565.0,
        "length": 140,
        "protein_name": "Fatty acid-binding protein 12",
        "gene_name": "FABP12",
        "organism": "Human",
        "refseq_name": "fatty acid-binding protein 12",
        "refseq_ac": "NP_001098751",
        "gene_names_uniprotkb": "FABP12",
        "gene_names_refseq": "FABP12",
        "protein_names_uniprotkb": "Fatty acid-binding protein 12",
        "protein_names_refseq": "Probable fatty acid-binding protein ENSP00000353650; fatty acid binding protein ORF; fatty acid-binding protein 12; intracellular fatty acid-binding protein FABP12",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:646486);  (R-HSA-163560)",
        "pathway_count": 2,
        "publication_count": 14,
        "publication_id_list": "10671541;11237011;12832420;15364929;15456755;16741517;17603008;18786628;19181555;21504868;26992070;30379171;30809827;33031638",
        "class_list": "",
        "function": "FABP12 arose as the result of tandem gene duplication, a mechanism that may have been instrumental to the expansion of the FABP family., [RefSeq, PubMed]; May play a role in lipid transport., [UniProtKB]; Study in a large, five-generation Han Chinese family with several patients presenting with Marie Unna hereditary hypotrichosis (MUHH) and multiple familial trichoepithelioma (MFT) revealed that the c.1A>G mutation in HR (U2HR) was present in all MUHH patients. No pathogenic variants were found in EPS8L3 or CYLD in any family members but FABP12 (rs536105592 G>A) was identified in the patients with both MUHH and MFT., [RefSeq, PubMed]; The FABP12/PPARgamma pathway promotes metastatic transformation by inducing epithelial-to-mesenchymal transition and lipid-derived energy production in prostate cancer cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7SUN0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0005504 fatty acid binding;GO:0008289 lipid binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol",
        "go_biological_process": "GO:0015908 fatty acid transport;GO:0019433 triglyceride catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "A6NFH5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96FN9-1",
        "uniprot_id": "DTD2_HUMAN",
        "mass": 18660.0,
        "length": 168,
        "protein_name": "D-aminoacyl-tRNA deacylase 2",
        "gene_name": "DTD2",
        "organism": "Human",
        "refseq_name": "D-aminoacyl-tRNA deacylase 2",
        "refseq_ac": "NP_542395",
        "gene_names_uniprotkb": "DTD2; C14orf126",
        "gene_names_refseq": "ATD; C14orf126; DTD2",
        "protein_names_uniprotkb": "D-aminoacyl-tRNA deacylase 2; 3.1.1.96; ATD; Animalia-specific tRNA deacylase; D-tyrosyl-tRNA(Tyr) deacylase 2; L-alanyl-tRNA deacylase",
        "protein_names_refseq": "D-aminoacyl-tRNA deacylase 2; D-tyrosyl-tRNA deacylase 2 (putative); L-alanyl-tRNA deacylase; animalia-specifc tRNA deacylase; animalia-specific tRNA deacylase; probable D-tyrosyl-tRNA(Tyr) deacylase 2; putative D-tyrosyl-tRNA deacylase 2; putative D-tyrosyl-tRNA(Tyr) deacylase 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:112487)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;25418920;26992070;27846572;27920218;28832583;29410408;30779550;31844290;32157095;33912179;34211107;35561310;35580925",
        "class_list": "",
        "function": "Deacylates mischarged D-aminoacyl-tRNAs (By similarity). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity). Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity). Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS (PubMed:29410408). Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408). Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation (By similarity)., [UniProtKB, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DS87",
        "ec_number_list": "3.1.1.96",
        "go_molecular_function": "GO:0051500 D-tyrosyl-tRNA(Tyr) deacylase activity;GO:0106105 Ala-tRNA(Thr) deacylase activity;GO:0000049 tRNA binding;GO:0106026 Gly-tRNA(Ala) deacylase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006399 tRNA metabolic process;GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q96FN9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BSR8-1",
        "uniprot_id": "YIPF4_HUMAN",
        "mass": 27083.0,
        "length": 244,
        "protein_name": "Protein YIPF4",
        "gene_name": "YIPF4",
        "organism": "Human",
        "refseq_name": "protein YIPF4",
        "refseq_ac": "NP_115688",
        "gene_names_uniprotkb": "YIPF4; Nbla11189",
        "gene_names_refseq": "FinGER4; Nbla11189; YIPF4; YIPFalpha2",
        "protein_names_uniprotkb": "Protein YIPF4; YIP1 family member 4",
        "protein_names_refseq": "YIP1 family member 4; protein YIPF4; putative protein product of Nbla11189",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84272)",
        "pathway_count": 1,
        "publication_count": 47,
        "publication_id_list": "11237011;12880961;21757827;22645359;24715725;25418920;25502872;25645385;26235900;26929215;26992070;27999994;28218747;28228285;28514659;28904123;29242379;29437277;29557506;29632711;29769354;29786170;30315122;30410026;31020640;31217245;31530632;31844290;32157095;32161166;32488085;32938616;33592498;33633747;33936100;33968037;33981976;34171305;34357683;34433824;34561969;34932366;35051231;35154160;36215666;36241641;36284347",
        "class_list": "",
        "function": "Involved in the maintenance of the Golgi structure., [UniProtKB, PubMed]; The significance of YIPF4 protein for the maintenance of the morphology of the Golgi was tested by RNA interference, revealing a number of specific morphological changes to this organelle on their depletion., [RefSeq, PubMed]; YIPF4 is a binding partner of the papillomavirus E5 proteins. Publication Status: Online-Only, [RefSeq, PubMed]; YIPF4 was detected as a single mobility form consistent with its predicted molecular weight, three different mobility forms of YIPF3 were detected by western blotting., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005802 trans-Golgi network",
        "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048280 vesicle fusion with Golgi apparatus",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q9BSR8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P11684-1",
        "uniprot_id": "UTER_HUMAN",
        "mass": 9994.0,
        "length": 91,
        "protein_name": "Uteroglobin",
        "gene_name": "SCGB1A1",
        "organism": "Human",
        "refseq_name": "uteroglobin precursor",
        "refseq_ac": "NP_003348",
        "gene_names_uniprotkb": "SCGB1A1; CC10; CCSP; UGB",
        "gene_names_refseq": "CC10; CC16; CCPBP; CCSP; SCGB1A1; UGB; UP-1; UP1",
        "protein_names_uniprotkb": "Uteroglobin; CC10; CCPBP; Club cell phospholipid-binding protein; Club cells 10 kDa secretory protein; Secretoglobin family 1A member 1; UP-1; UP1; Urinary protein 1; Urine protein 1",
        "protein_names_refseq": "Uteroglobin (club-cell specific 10-kD protein); blastokinin; club cell 10 kDa secretory protein; club cell phospholipid-binding protein; club cell protein 16; club cells 10 kDa secretory protein; club secretory protein 16; secretoglobin, family 1A, member 1 (uteroglobin); urinary protein 1; urine protein 1; uteroglobin precursor",
        "tax_id": 9606,
        "disease": "otitis media (Disease Ontology:DOID:10754); meconium aspiration syndrome (Disease Ontology:DOID:11049); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); pulmonary fibrosis (Disease Ontology:DOID:3770); pulmonary eosinophilia (Disease Ontology:DOID:9498)",
        "pathway": " (hsa:7356)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11237011;11788998;1284526;1395029;1400743;16423471;20058876;23964685;29557506;3167058;35051231;36311771;36352422;37523710;38053993;38110551;7664082;7733299",
        "class_list": "",
        "function": "Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2., [UniProtKB]; Brief Research Report: Serum clara cell 16 kDa protein levels are increased in patients hospitalized for severe SARS-CoV-2 or sepsis infection. Publication Status: Online-Only, [RefSeq, PubMed]; CC16 drives VLA-2-dependent SPLUNC1 expression. Publication Status: Online-Only, [RefSeq, PubMed]; CC16 polymorphisms in asthma, asthma subtypes, and asthma control in adults from the Agricultural Lung Health Study. Erratum:[Respir Res. 2022 Dec 16;23(1):350. doi: 10.1186/s12931-022-02261-w. PMID: 36527017] Publication Status: Online-Only, [RefSeq, PubMed]; Circulating CC16 and Asthma: A Population-based, Multicohort Study from Early Childhood through Adult Life., [RefSeq, PubMed]; Club cell protein (CC16) in serum as an effect marker for small airway epithelial damage caused by diesel exhaust and blasting fumes in potash mining., [RefSeq, PubMed]; This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 11,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5F2;Q6FHH3;Q9UCM2;Q9UCM4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019834 phospholipase A2 inhibitor activity;GO:0097160 polychlorinated biphenyl binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0030141 secretory granule;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0034021 response to silicon dioxide;GO:0007165 signal transduction;GO:0032496 response to lipopolysaccharide;GO:0051384 response to glucocorticoid;GO:0007565 female pregnancy",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "P11684-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q2M2I3-1",
        "uniprot_id": "FA83E_HUMAN",
        "mass": 51780.0,
        "length": 478,
        "protein_name": "Protein FAM83E",
        "gene_name": "FAM83E",
        "organism": "Human",
        "refseq_name": "protein FAM83E",
        "refseq_ac": "NP_060178",
        "gene_names_uniprotkb": "FAM83E",
        "gene_names_refseq": "FAM83E; SACK1E",
        "protein_names_uniprotkb": "Protein FAM83E",
        "protein_names_refseq": "family with sequence similarity 83 member E; protein FAM83E",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54854)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11237011;19913121;20628086;22898188;24736947;26154972;29789297;31611695;39894887",
        "class_list": "",
        "function": "May play a role in MAPK signaling., [UniProtKB, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9NXK1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019901 protein kinase binding",
        "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q2M2I3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NX14-1",
        "uniprot_id": "NDUBB_HUMAN",
        "mass": 17317.0,
        "length": 153,
        "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial",
        "gene_name": "NDUFB11",
        "organism": "Human",
        "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial isoform 2",
        "refseq_ac": "NP_001129470",
        "gene_names_uniprotkb": "NDUFB11; PRO1064",
        "gene_names_refseq": "CI-ESSS; ESSS; MC1DN30; NDUFB11; NP17.3; Np15; P17.3",
        "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial; CI-ESSS; Complex I-ESSS; NADH-ubiquinone oxidoreductase ESSS subunit; Neuronal protein 17.3; Np17.3; p17.3",
        "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial isoform 2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial; NADH-ubiquinone oxidoreductase ESSS subunit; complex I NP17.3 subunit; complex I-ESSS; neuronal protein 17.3",
        "tax_id": 9606,
        "disease": "linear skin defects with multiple congenital anomalies 3 (Disease Ontology:DOID:0111876); nuclear type mitochondrial complex I deficiency 30 (Disease Ontology:DOID:0112098)",
        "pathway": " (hsa:54539);  (R-HSA-611105);  (R-HSA-6799198)",
        "pathway_count": 3,
        "publication_count": 105,
        "publication_id_list": "10327278;10544803;11220739;11237011;11695836;12231006;12611891;12837546;12975309;1327877;14741580;15250827;16230336;17033964;17936786;186667;19752196;20406883;20552642;20858599;21924235;23150584;23270816;23481700;23553477;23564345;23747254;239860;24191001;24714562;25418920;25564869;25645385;25678554;25772934;25921236;26375851;26728094;26741492;26992070;27499296;27626371;27726376;27846572;27920218;28218747;28228285;28489076;28510447;28832583;28834231;29242379;29393594;29493099;29557506;29632046;29632711;29786170;30192525;30379171;30429286;31154438;31206022;31217245;31222486;31530632;31611695;31666358;31844290;31848261;31866046;32157095;32161166;32320651;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33691108;33879611;33882309;33912179;33968037;34087483;34171305;34357683;34561969;35333655;35580925;35614220;36010968;36241641;36675256;37642954;37938771;38199007;40596516;4288886;9571201;9878551",
        "class_list": "",
        "function": "A Novel Mutation Associated with Neonatal Lethal Cardiomyopathy Leads to an Alternative Transcript Expression in the X-Linked Complex I NDUFB11 Gene. Publication Status: Online-Only, [RefSeq, PubMed]; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NDUFB11 and NDUFS3 play a role in atherosclerosis and chronic stress., [RefSeq, PubMed]; The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to ubiquinone. Mutations in the human gene are associated with linear skin defects with multiple congenital anomalies 3 and mitochondrial complex I deficiency. [provided by RefSeq, Dec 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5JRR3;Q5JRR4;Q6IAB6;Q8WZ96;Q9BXX9",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I",
        "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration",
        "synthesized_glycan_count": 0,
        "hit_score": 10.8,
        "record_id": "Q9NX14-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H7V2-1",
        "uniprot_id": "SYNG1_HUMAN",
        "mass": 28551.0,
        "length": 258,
        "protein_name": "Synapse differentiation-inducing gene protein 1",
        "gene_name": "SYNDIG1",
        "organism": "Human",
        "refseq_name": "synapse differentiation-inducing gene protein 1",
        "refseq_ac": "NP_001310535",
        "gene_names_uniprotkb": "SYNDIG1; C20orf39; TMEM90B",
        "gene_names_refseq": "C20orf39; DSPC2; IFITMD5; SYNDIG1; TMEM90B",
        "protein_names_uniprotkb": "Synapse differentiation-inducing gene protein 1; DSPC2; Dispanin subfamily C member 2; SynDIG1; Transmembrane protein 90B",
        "protein_names_refseq": "dispanin subfamily C member 2; interferon induced transmembrane protein domain containing 5; synapse differentiation induced gene 1; synapse differentiation-inducing gene protein 1; transmembrane protein 90B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79953)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "22363774;25505266;30192525;30429286;35051231",
        "class_list": "",
        "function": "May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation., [UniProtKB]; This gene encodes a protein that belongs to the interferon-induced transmembrane family of proteins. A similar protein in rat is thought to regulate the development of excitatory synapses. [provided by RefSeq, Jul 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IA30;Q9H514",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0035254 glutamate receptor binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine;GO:0043198 dendritic shaft",
        "go_biological_process": "GO:0097091 synaptic vesicle clustering;GO:0006886 intracellular protein transport;GO:0051965 positive regulation of synapse assembly;GO:0150052 regulation of postsynapse assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q9H7V2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15164-1",
        "uniprot_id": "TIF1A_HUMAN",
        "mass": 116831.0,
        "length": 1050,
        "protein_name": "Transcription intermediary factor 1-alpha",
        "gene_name": "TRIM24",
        "organism": "Human",
        "refseq_name": "transcription intermediary factor 1-alpha isoform b",
        "refseq_ac": "NP_003843",
        "gene_names_uniprotkb": "TRIM24; RNF82; TIF1A; TIF1",
        "gene_names_refseq": "PTC6; RNF82; TF1A; TIF1ALPHA; TIF1A; TIF1; TRIM24; hTIF1",
        "protein_names_uniprotkb": "Transcription intermediary factor 1-alpha; 2.3.2.27; E3 ubiquitin-protein ligase TRIM24; RING finger protein 82; RING-type E3 ubiquitin transferase TIF1-alpha; TIF1-alpha; Tripartite motif-containing protein 24",
        "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM24; RING finger protein 82; RING-type E3 ubiquitin transferase TIF1-alpha; TIF1-alpha; transcription intermediary factor 1-alpha isoform b; transcriptional intermediary factor 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8805);  (R-HSA-1839117);  (R-HSA-5655302);  (R-HSA-6802952)",
        "pathway_count": 4,
        "publication_count": 176,
        "publication_id_list": "10022127;10439047;10480903;10579907;10652257;10688839;10887137;10918587;10935490;10935545;11157491;11429702;11689702;11739186;12124177;12393597;14534538;14660670;15034873;15050920;15448205;15609342;15630448;15800673;16091734;16322096;16844695;16946300;17081983;17322306;17344846;17505008;17525332;17533378;17698633;18205209;18212344;18337450;18373495;18381441;18412956;18452278;18552176;18669648;18757403;18974108;19103595;19147536;19369959;19381019;19413330;19556538;19651622;19664995;19690332;19749790;19809159;19874848;19909775;19946327;20068231;20094046;20179196;20226962;20526349;20709759;21160078;21164480;21330321;21406692;21424530;21666749;21711248;22629402;22745804;22898188;23186163;23481700;23583981;24135138;24345920;24714562;24715725;24820418;25114211;25204415;25218447;25418920;25576301;25593309;25645385;25755297;25772364;25907612;26154972;26728094;26811146;26929215;26992070;27543614;27600516;27846572;27893789;27920218;28218747;28228285;28446606;28832583;28834231;28904123;29242379;29393594;29437277;29557506;29632711;29786170;29789417;30315122;30429286;30484775;30524438;30620550;31844290;32119511;32157095;32324863;32387766;32488085;32502341;32897882;32938616;32938750;32983136;33141586;33214551;33298915;33392160;33537174;33592498;33691108;33724611;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34405274;34509645;34932366;35051231;35132862;35318648;35580925;36010968;36215666;36241641;36284347;36550358;36690785;37075063;37938771;38514847;38665916;38828688;39302247;39534244;9115274;9425908;9576949;9716603;9857065;9949182",
        "class_list": "",
        "function": "Novel insights into the recognition of acetylated histone H4 tail by the TRIM24 PHD-Bromo module. Erratum:[Biochem J. 2023 May 31;480(10):751. doi: 10.1042/BCJ-2023-0011_COR. PMID: 37255272], [RefSeq, PubMed]; Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer., [RefSeq, PubMed]; TRIM24 Cooperates with Ras Mutation to Drive Glioma Progression through snoRNA Recruitment of PHAX and DNA-PKcs., [RefSeq, PubMed]; TRIM24 controls induction of latent HIV-1 by stimulating transcriptional elongation. Publication Status: Online-Only, [RefSeq, PubMed]; TRIM24 is critical for the cellular response to DNA double-strand breaks through regulating the recruitment of MRN complex., [RefSeq, PubMed]; The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 19,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D1R7;A4D1R8;O95854",
        "ec_number_list": "2.3.2.27;2.7.10.2;3.6.5.2;2.7.11.1;2.7.10.1;3.1.4.11;2.7.11.24;2.7.12.2;2.7.10.4;2.7.1.153;2.7.1.137;3.6.4.-;2.7.11.17;2.7.1.107;2.7.1.94;2.7.1.138;2.7.7.-;2.7.7.19;1.14.11.65;3.1.31.1",
        "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0004672 protein kinase activity;GO:0005102 signaling receptor binding",
        "go_cellular_component": "GO:0005726 perichromatin fibrils;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:0031647 regulation of protein stability;GO:0016567 protein ubiquitination;GO:0006366 transcription by RNA polymerase II;GO:0042981 regulation of apoptotic process;GO:0043434 response to peptide hormone",
        "synthesized_glycan_count": 0,
        "hit_score": 18.5,
        "record_id": "O15164-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96GJ1-1",
        "uniprot_id": "TRM2B_HUMAN",
        "mass": 56476.0,
        "length": 504,
        "protein_name": "tRNA (uracil-5-)-methyltransferase homolog B",
        "gene_name": "TRMT2B",
        "organism": "Human",
        "refseq_name": "tRNA (uracil-5-)-methyltransferase homolog B isoform a",
        "refseq_ac": "NP_001161442",
        "gene_names_uniprotkb": "TRMT2B; CXorf34",
        "gene_names_refseq": "CXorf34; TRMT2B; dJ341D10.3",
        "protein_names_uniprotkb": "tRNA (uracil-5-)-methyltransferase homolog B; 2.1.1.-; 2.1.1.35; TRM2 homolog B; rRNA (uracil-5-)-methyltransferase TRMT2B",
        "protein_names_refseq": "TRM2 homolog B; TRM2 homolog; TRM2 tRNA methyltransferase 2 homolog B; rRNA (uracil-5-)-methyltransferase TRMT2B; tRNA (uracil(54)-C(5))-methyltransferase homolog; tRNA (uracil-5-)-methyltransferase homolog B isoform a; tRNA (uracil-5-)-methyltransferase homolog B; tRNA (uracil-5-)-methyltransferase homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79979)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "24715725;26992070;27184847;29437277;29557506;31948311;32387766;32502341;33968037;34357683;34556860;37874476",
        "class_list": "",
        "function": "Association of TRMT2B gene variants with juvenile amyotrophic lateral sclerosis., [RefSeq, PubMed]; Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and 12S rRNA (PubMed:31948311, PubMed:34556860). Catalyzes the methylation of uridine at position 54 (m5U54) in all tRNAs (PubMed:31948311). Specifically methylates the uridine in position 429 of 12S rRNA (m5U429) (PubMed:31948311). Does not affect RNA stability or mitochondrial translation (PubMed:31948311)., [UniProtKB, PubMed, PubMed]; TRMT2B is responsible for both tRNA and rRNA m(5)U-methylation in human mitochondria., [RefSeq, PubMed]; This gene encodes a homolog of the TRM2 gene in S. cerevisiae. The yeast gene encodes a tRNA methyltransferase that plays a role in tRNA maturation. The yeast protein also has endo-exonuclease activity and may be involved in DNA double strand break repair. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Nov 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NDG5;A6NEI9;A6NMG6;Q5JPF0;Q5JVY6;Q96HU7;Q96IH9;Q9H9K2",
        "ec_number_list": "2.1.1.-;2.1.1.35",
        "go_molecular_function": "GO:0030697 tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent;GO:0070041 rRNA (uridine-C5-)-methyltransferase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0008033 tRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q96GJ1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P23025-1",
        "uniprot_id": "XPA_HUMAN",
        "mass": 31368.0,
        "length": 273,
        "protein_name": "DNA repair protein complementing XP-A cells",
        "gene_name": "XPA",
        "organism": "Human",
        "refseq_name": "DNA repair protein complementing XP-A cells isoform 1",
        "refseq_ac": "NP_000371",
        "gene_names_uniprotkb": "XPA; XPAC",
        "gene_names_refseq": "XP1; XPAC; XPA",
        "protein_names_uniprotkb": "DNA repair protein complementing XP-A cells; Xeroderma pigmentosum group A-complementing protein",
        "protein_names_refseq": "DNA repair protein complementing XP-A cells isoform 1; DNA repair protein complementing XP-A cells; xeroderma pigmentosum group A-complementing protein; xeroderma pigmentosum, complementation group A",
        "tax_id": 9606,
        "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); xeroderma pigmentosum group A (Disease Ontology:DOID:0110843)",
        "pathway": " (hsa:7507);  (R-HSA-5696395);  (R-HSA-5696400);  (R-HSA-6781823);  (R-HSA-6782135)",
        "pathway_count": 5,
        "publication_count": 110,
        "publication_id_list": "10447254;10526214;10563794;10734143;10944529;11007478;11141066;11237011;11278856;11511374;11904382;12080057;12208738;12660172;12732143;1339397;1372103;14517266;15220921;15590680;1601884;16030353;16246722;16491090;16540648;16751180;17000769;17290000;17466625;17466626;17948053;17981804;18079701;18614043;19056823;1918083;19197159;19279666;19661379;19713942;19940136;19941824;20227374;20304803;20368362;20876134;21070792;21282463;22081108;22118460;2234061;22466610;22466611;22466612;22902626;23038248;23045548;23178497;23186163;23352696;23751493;24127601;24402227;25154395;25218447;25435140;25538220;26042670;26151477;26992070;27247238;27600516;27920218;28467828;28832583;29242379;29493099;30327428;30379171;30429286;31253769;31779191;31998317;32157095;32355176;33123756;33298915;33717175;33968037;33981976;35216341;35580925;36284347;36893274;37076618;37510255;7559382;7700386;8078911;8294029;8504220;8543191;8692841;8876179;9130708;9326587;9671271;9699634;9716411;9771713",
        "class_list": "",
        "function": "A Significant Increasing Risk Association between Cigarette Smoking and XPA and XPC Genes Polymorphisms. Publication Status: Online-Only, [RefSeq, PubMed]; A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair., [RefSeq, PubMed]; Involved in DNA nucleotide excision repair (NER). Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation (PubMed:19197159). During NER stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). Connects XPD/ERCC2 and XPB/ERCC3 during NER, retaining DNA near the XPB/ERCC3 active site, and stabilizing the complex in a different conformation than in transcribing TFIIH (PubMed:31253769)., [UniProtKB, PubMed, PubMed]; Lesion recognition by XPC, TFIIH and XPA in DNA excision repair., [RefSeq, PubMed]; This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017]., [RefSeq]; XPA is a key scaffold protein for human nucleotide excision repair. (Review) Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T1U9;Q6LCW7;Q6LD02",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0003684 damaged DNA binding;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0000110 nucleotide-excision repair factor 1 complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body",
        "go_biological_process": "GO:0006281 DNA repair;GO:0006284 base-excision repair;GO:0034504 protein localization to nucleus;GO:0070914 UV-damage excision repair;GO:0000715 nucleotide-excision repair, DNA damage recognition",
        "synthesized_glycan_count": 0,
        "hit_score": 11.3,
        "record_id": "P23025-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P57081-1",
        "uniprot_id": "WDR4_HUMAN",
        "mass": 45490.0,
        "length": 412,
        "protein_name": "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4",
        "gene_name": "WDR4",
        "organism": "Human",
        "refseq_name": "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform 2",
        "refseq_ac": "NP_001247403",
        "gene_names_uniprotkb": "WDR4",
        "gene_names_refseq": "GAMOS6; MIGSB; TRM82; TRMT82; WDR4; Wuho; hWH",
        "protein_names_uniprotkb": "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Protein Wuho homolog; WD repeat-containing protein 4; hWH",
        "protein_names_refseq": "TRM82 tRNA methyltransferase 82 homolog; WD repeat domain 4 METTL1 scaffold protein; WD repeat domain 4; WD repeat-containing protein 4; protein Wuho homolog; tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform 2; tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4",
        "tax_id": 9606,
        "disease": "Seckel syndrome (Disease Ontology:DOID:0050569); Galloway-Mowat syndrome 6 (Disease Ontology:DOID:0061289); Galloway-Mowat syndrome (Disease Ontology:DOID:0080694); microcephaly, growth deficiency, seizures, and brain malformations (Disease Ontology:DOID:0081051)",
        "pathway": " (hsa:10785);  (R-HSA-6782315)",
        "pathway_count": 2,
        "publication_count": 102,
        "publication_id_list": "10430867;10950928;10982862;11027153;11111046;12403464;15861136;15870694;15994936;16043508;16424344;17071714;17322306;18567810;18669648;18767875;19017811;19413330;19414587;19651622;20068231;20123966;20308323;20354154;20584901;21059936;21131277;21406692;22344696;22591353;22995836;23042678;23048041;23186163;23381944;23604283;24126054;24204302;24397554;24714562;24901367;25261850;25404562;25418920;25576301;25916855;26024233;26160102;26310293;26375851;26416026;26728094;26751069;26811146;26992070;27055666;28218747;28228285;28514659;28617965;28832583;28834231;28904123;29242379;29393594;29437277;29597095;29632046;30079490;30315122;30410026;31031083;31031084;31481669;31844290;32157095;32357974;32938616;33298915;33592498;33691108;33912179;33981976;34087483;34352206;34352207;34371184;35051231;35561310;35580925;36599982;36599985;36610787;37217939;37369656;37379838;37821451;38493882;39251572;39894887;9430663;9851972",
        "class_list": "",
        "function": "Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage. Publication Status: Online-Only, [RefSeq, PubMed]; Non-catalytic component of the METTL1-WDR4 methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031083, PubMed:31031084, PubMed:36599982, PubMed:36599985, PubMed:37369656). In the METTL1-WDR4 methyltransferase complex, WDR4 acts as a scaffold for tRNA-binding (PubMed:36599982, PubMed:36599985, PubMed:37369656). Required for the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop (PubMed:12403464, PubMed:34352206, PubMed:34352207, PubMed:36599982, PubMed:36599985, PubMed:37369656). M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay (PubMed:36599982, PubMed:36599985). Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs (PubMed:31031084, PubMed:37379838). Also required for methylation of a specific subset of miRNAs, such as let-7 (PubMed:31031083). Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 (PubMed:26751069)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target. Erratum:[Cell Death Dis. 2024 Jul 2;15(7):468. doi: 10.1038/s41419-024-06747-x. PMID: 38956428] Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]., [RefSeq]; WDR4 promotes HCC pathogenesis through N[7]-methylguanosine by regulating and interacting with METTL1., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KA58;B2RCA3;B4DNQ7;D3DSK3;Q9BVM5;Q9HCR3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008047 enzyme activator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005694 chromosome;GO:0043527 tRNA methyltransferase complex",
        "go_biological_process": "GO:0006400 tRNA modification;GO:0006974 DNA damage response;GO:0106004 tRNA (guanine-N7)-methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 10.5,
        "record_id": "P57081-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P11169-1",
        "uniprot_id": "GTR3_HUMAN",
        "mass": 53924.0,
        "length": 496,
        "protein_name": "Solute carrier family 2, facilitated glucose transporter member 3",
        "gene_name": "SLC2A3",
        "organism": "Human",
        "refseq_name": "solute carrier family 2, facilitated glucose transporter member 3",
        "refseq_ac": "NP_008862",
        "gene_names_uniprotkb": "SLC2A3; GLUT3",
        "gene_names_refseq": "GLUT3; SLC2A3",
        "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 3; GLUT-3; Glucose transporter type 3, brain",
        "protein_names_refseq": "GLUT-3; glucose transporter type 3, brain; solute carrier family 2 (facilitated glucose transporter), member 3; solute carrier family 2, facilitated glucose transporter member 3",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); acanthosis nigricans (Disease Ontology:DOID:3138); cataract (Disease Ontology:DOID:83); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:6515);  (R-HSA-189200);  (R-HSA-196836);  (R-HSA-6798695);  (R-HSA-9022699)",
        "pathway_count": 5,
        "publication_count": 99,
        "publication_id_list": "10471399;10556483;10556521;10783391;10821868;10860667;10862609;10970791;10987651;11133510;11237011;11245466;11247674;11396616;11425315;11583593;11681785;11741323;11780755;11832379;11994746;12504846;12590146;12885248;1415574;14614622;14739288;14997204;15033637;15607332;15902306;15970797;16154905;16550171;17050778;1756912;17635959;18063724;18327257;18452278;18578522;1918382;19413330;19651622;19664994;20616166;21107422;21940664;22212718;22521588;23090970;23650620;24150225;25424712;25502872;26176916;26214522;26375851;2656669;26650681;28510447;28832583;29242379;29493099;30573663;31020640;31611695;3170580;32162841;32265295;32350084;32860739;32938616;32983136;33043033;33592498;33912179;33936100;33968037;34357683;34725712;35051231;35154160;35251023;35810171;36215666;37258572;37721853;37750639;38396757;38625978;7668255;8457197;8513896;8692836;9228080;9354798;9477959;9751501",
        "class_list": "glycogene",
        "function": "Concurrent presence of diabetes affects the GLUT3 programming of glucose metabolism in glioblastoma., [RefSeq, PubMed]; Facilitative glucose transporter (PubMed:26176916, PubMed:32860739, PubMed:9477959). Can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:26176916, PubMed:9477959). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:26176916, PubMed:9477959). Does not mediate fructose transport (PubMed:26176916, PubMed:9477959). Required for mesendoderm differentiation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing. Publication Status: Online-Only, [RefSeq, PubMed]; Glut-3 Gene Knockdown as a Potential Strategy to Overcome Glioblastoma Radioresistance. Publication Status: Online-Only, [RefSeq, PubMed]; SLC2A3 promotes tumor progression through lactic acid-promoted TGF-beta signaling pathway in oral squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 636,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R606;D3DUU6;Q6I9U2;Q9UG15",
        "ec_number_list": "",
        "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0005536 D-glucose binding;GO:0055056 D-glucose transmembrane transporter activity;GO:0005354 galactose transmembrane transporter activity;GO:0022857 transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0035579 specific granule membrane;GO:0043204 perikaryon;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0005975 carbohydrate metabolic process;GO:0019852 L-ascorbic acid metabolic process;GO:0015757 galactose transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 10.3,
        "record_id": "P11169-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZS86-1",
        "uniprot_id": "GLPK5_HUMAN",
        "mass": 59156.0,
        "length": 529,
        "protein_name": "Glycerol kinase 5",
        "gene_name": "GK5",
        "organism": "Human",
        "refseq_name": "glycerol kinase 5",
        "refseq_ac": "NP_001034636",
        "gene_names_uniprotkb": "GK5",
        "gene_names_refseq": "GK5",
        "protein_names_uniprotkb": "Glycerol kinase 5; 2.7.1.30; ATP:glycerol 3-phosphotransferase 5; GK 5; Glycerokinase 5",
        "protein_names_refseq": "ATP:glycerol 3-phosphotransferase 5; GK 5; glycerokinase 5; glycerol kinase 5 (putative); glycerol kinase 5; putative glycerol kinase 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:256356)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11237011;25936394;26992070;28467828;28832583;29242379;29493099;29769354;31844290;32350084;32938616;33592498;33633747;33912179;33968037;34171305;35251023;36241641",
        "class_list": "",
        "function": "MiR-135b may function as an oncogene by inhibiting GK5 in glioblastoma., [RefSeq, PubMed]; Skin-specific kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Involved in skin-specific regulation of sterol regulatory element-binding protein (SREBP) processing and lipid biosynthesis., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R9I2;D3DNG2;Q8N2A7;Q8N5E6",
        "ec_number_list": "2.7.1.30",
        "go_molecular_function": "GO:0004370 glycerol kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0016773 phosphotransferase activity, alcohol group as acceptor",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion",
        "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0046167 glycerol-3-phosphate biosynthetic process;GO:0006641 triglyceride metabolic process;GO:0006071 glycerol metabolic process;GO:0005975 carbohydrate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q6ZS86-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6UWU2-1",
        "uniprot_id": "GLB1L_HUMAN",
        "mass": 74158.0,
        "length": 654,
        "protein_name": "Beta-galactosidase-1-like protein",
        "gene_name": "GLB1L",
        "organism": "Human",
        "refseq_name": "beta-galactosidase-1-like protein isoform 1 precursor",
        "refseq_ac": "NP_001273352",
        "gene_names_uniprotkb": "GLB1L; PRO262",
        "gene_names_refseq": "GLB1L",
        "protein_names_uniprotkb": "Beta-galactosidase-1-like protein; 3.2.1.23",
        "protein_names_refseq": "beta-galactosidase-1-like protein isoform 1 precursor; beta-galactosidase-1-like protein; testicular tissue protein Li 74",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79411);  (R-HSA-2022857);  (R-HSA-2024101);  (R-HSA-9840310)",
        "pathway_count": 4,
        "publication_count": 138,
        "publication_id_list": "10.1101/2023.09.13.557529;10191093;10196694;10339581;10406958;10781797;10823942;10861246;10942779;10993717;11237011;11350180;11489889;11568288;11707436;11784319;12374214;12510003;12518053;12566438;12594539;12662933;12885774;12888274;12909021;12975309;1352293;1352993;1463457;15003450;15213228;1522213;15458386;15647514;15714521;15773042;15845354;16229686;16230343;1634229;16478472;16517606;16595074;16698036;1670590;1678251;17105727;1718266;1720305;1740330;1756715;1794986;1840600;18524657;1889421;1907800;1915858;19224584;1928092;19405096;1946389;19836391;19889881;2001789;20232353;20728381;2122463;22940367;23090970;235289;239890;24190977;2562955;25645385;25892735;2717620;28126847;29393594;29443946;29557506;2960521;2965147;29692406;2970528;2971395;29747811;2976757;29769354;29802621;3014515;3048308;3134052;3136930;31495489;31530632;3158659;3196333;32157095;32350084;32488085;32938616;33912179;33968037;34357683;3456607;3468507;35580925;37074911;39302247;39894887;39940;5135907;5164093;527942;5822067;7213753;738706;7504405;7628016;7730378;7744740;7852280;8213840;8281145;8370580;8399327;8573994;8591035;8663398;8804427;8889578;8955159;8985184;9217013;9223416;9338580;9520418;9521684",
        "class_list": "glycogene;glycosylhydrolase",
        "function": "Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 792,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 12,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96DR0",
        "ec_number_list": "3.2.1.23",
        "go_molecular_function": "GO:0004565 beta-galactosidase activity;GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds",
        "go_cellular_component": "GO:0005773 vacuole",
        "go_biological_process": "GO:0019388 galactose catabolic process;GO:0005975 carbohydrate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 15.6,
        "record_id": "Q6UWU2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P09471-1",
        "uniprot_id": "GNAO_HUMAN",
        "mass": 40051.0,
        "length": 354,
        "protein_name": "Guanine nucleotide-binding protein G(o) subunit alpha",
        "gene_name": "GNAO1",
        "organism": "Human",
        "refseq_name": "guanine nucleotide-binding protein G(o) subunit alpha isoform a",
        "refseq_ac": "NP_066268",
        "gene_names_uniprotkb": "GNAO1",
        "gene_names_refseq": "DEE17; EIEE17; G-ALPHA-o; GNAO1; GNAO; HG1G; NEDIM",
        "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(o) subunit alpha; 3.6.5.-",
        "protein_names_refseq": "GO2-q chimeric G-protein; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; guanine nucleotide-binding protein G(o) subunit alpha isoform a; guanine nucleotide-binding protein G(o) subunit alpha; guanine nucleotide-binding regulatory protein 2; heterotrimeric guanine nucleotide-binding protein 1G",
        "tax_id": 9606,
        "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); developmental and epileptic encephalopathy 17 (Disease Ontology:DOID:0080450); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); neurodevelopmental disorder with involuntary movements (Disease Ontology:DOID:0112276); McCune Albright syndrome (Disease Ontology:DOID:1858)",
        "pathway": " (hsa:2775);  (R-HSA-4086398)",
        "pathway_count": 2,
        "publication_count": 77,
        "publication_id_list": "10330115;10380924;10391246;10391247;10395542;10488343;10588714;10777564;10858654;11015615;11030334;11237011;11563835;12015605;12086864;12471263;12482967;12556497;12729560;12975316;14704854;14977528;15494017;15545263;15611108;16880514;16920709;17426020;17684012;18456304;18488142;1901650;19177143;19536106;19851316;21118996;21903638;22941947;23151663;23256519;23416699;23632248;23904219;23993195;25255805;25576301;25966631;26060304;26485252;26590425;27068059;27476654;27625011;27864847;28357411;2841328;29390993;29557506;29925951;31154438;3124840;31844290;32157095;32938616;33408414;34685729;35580925;36010968;37887313;38866563;38874642;38881224;39098231;39103320;40914422;9073455;9389482",
        "class_list": "",
        "function": "AAV9-Mediated Intrastriatal Delivery of GNAO1 Reduces Hyperlocomotion in Gnao1 Heterozygous R209H Mutant Mice. Publication Status: Online-Only, [RefSeq, PubMed]; CircGNAO1 suppresses hepatocellular carcinoma progression and metastasis via sponging miR-182-5p and regulating FOXO1 expression., [RefSeq, PubMed]; Clinical Cases and the Molecular Profiling of a Novel Childhood Encephalopathy-Causing GNAO1 Mutation P170R. Publication Status: Online-Only, [RefSeq, PubMed]; Clinical and Molecular Profiling in GNAO1 Permits Phenotype-Genotype Correlation., [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Neomorphic Galphao mutations gain interaction with Ric8 proteins in GNAO1 encephalopathies. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P29777;Q8TD72;Q9UMV4",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.1.-;3.6.5.4;2.7.11.1;3.6.-.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0031821 G protein-coupled serotonin receptor binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031683 G-protein beta/gamma-subunit complex binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite",
        "go_biological_process": "GO:0006936 muscle contraction;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007212 G protein-coupled dopamine receptor signaling pathway;GO:0046676 negative regulation of insulin secretion",
        "synthesized_glycan_count": 0,
        "hit_score": 8.0,
        "record_id": "P09471-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14626-1",
        "uniprot_id": "GP171_HUMAN",
        "mass": 36754.0,
        "length": 319,
        "protein_name": "G protein-coupled receptor 171",
        "gene_name": "GPR171",
        "organism": "Human",
        "refseq_name": "G-protein coupled receptor 171",
        "refseq_ac": "NP_037440",
        "gene_names_uniprotkb": "GPR171; H963",
        "gene_names_refseq": "GPR171; H963",
        "protein_names_uniprotkb": "G protein-coupled receptor 171; G protein-coupled receptor H963",
        "protein_names_refseq": "F730001G15Rik; G-protein coupled receptor 171; G-protein coupled receptor H963; platelet activating receptor homolog; probable G-protein coupled receptor 171",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:29909)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11237011;11524702;24190977;24715725;26760963;26992070;28832583;29242379;34615877;9370294",
        "class_list": "",
        "function": "G protein-coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to Big LEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception (By similarity). Acts as a negative regulator T cell function (PubMed:34615877)., [UniProtKB, PubMed, UniProtKB]; High GPR171 expression enhances proliferation and metastasis of lung cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DNJ4;Q8IV06",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity;GO:0045028 G protein-coupled purinergic nucleotide receptor activity;GO:0008188 neuropeptide receptor activity;GO:0042923 neuropeptide binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0051930 regulation of sensory perception of pain;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0060259 regulation of feeding behavior",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "O14626-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P51674-1",
        "uniprot_id": "GPM6A_HUMAN",
        "mass": 31210.0,
        "length": 278,
        "protein_name": "Neuronal membrane glycoprotein M6-a",
        "gene_name": "GPM6A",
        "organism": "Human",
        "refseq_name": "neuronal membrane glycoprotein M6-a isoform 4",
        "refseq_ac": "NP_001248377",
        "gene_names_uniprotkb": "GPM6A; M6A",
        "gene_names_refseq": "GPM6A; GPM6; M6A",
        "protein_names_uniprotkb": "Neuronal membrane glycoprotein M6-a; M6a",
        "protein_names_refseq": "neuronal membrane glycoprotein M6-a isoform 4; neuronal membrane glycoprotein M6-a",
        "tax_id": 9606,
        "disease": "intellectual disability (Disease Ontology:DOID:1059); depressive disorder (Disease Ontology:DOID:1596)",
        "pathway": " (hsa:2823)",
        "pathway_count": 1,
        "publication_count": 22,
        "publication_id_list": "11237011;12359212;18510355;19298174;22223895;24705354;25502872;25892735;28514659;29557506;30573663;31154438;31844290;32248748;32350084;32387766;34357683;37742376;37855702;38317355;8661015;8893821",
        "class_list": "",
        "function": "A comprehensive study on identifying the structural and functional SNPs of human neuronal membrane glycoprotein M6A (GPM6A)., [RefSeq, PubMed]; H3K18 lactylation promotes the progression of arsenite-related idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP., [RefSeq, PubMed]; Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m6A Demethylation., [RefSeq, PubMed]; Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor., [UniProtKB, PubMed]; M6A methylation-regulated autophagy may be a new therapeutic target for intervertebral disc degeneration. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z642;E9PHI5;Q92602",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005262 calcium channel activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043197 dendritic spine",
        "go_biological_process": "GO:0003407 neural retina development;GO:0031175 neuron projection development;GO:0048863 stem cell differentiation;GO:0001764 neuron migration;GO:0048812 neuron projection morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "P51674-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BT04-1",
        "uniprot_id": "FUZZY_HUMAN",
        "mass": 45679.0,
        "length": 418,
        "protein_name": "Protein fuzzy homolog",
        "gene_name": "FUZ",
        "organism": "Human",
        "refseq_name": "protein fuzzy homolog isoform 2",
        "refseq_ac": "NP_001165408",
        "gene_names_uniprotkb": "FUZ; FY",
        "gene_names_refseq": "CPLANE3; FUZ; FY; NTD",
        "protein_names_uniprotkb": "Protein fuzzy homolog",
        "protein_names_refseq": "ciliogenesis and planar polarity effector 3; ciliogenesis and planar polarity effector complex subunit 3; protein fuzzy homolog isoform 2; protein fuzzy homolog",
        "tax_id": 9606,
        "disease": "ciliopathy (Disease Ontology:DOID:0060340); neural tube defect (Disease Ontology:DOID:0080074)",
        "pathway": " (hsa:80199);  (R-HSA-5610787)",
        "pathway_count": 2,
        "publication_count": 94,
        "publication_id_list": "10966113;11237011;11375483;12192414;12435627;14603322;15087129;15930098;16061793;16136078;16229832;16254602;16311594;16339192;16396903;16493421;16707575;17027958;17200122;17442700;17553904;17641202;17762891;17960137;18327258;18455992;18832070;19000668;19196978;19223390;19286674;19365551;19549984;19592253;19666503;19767740;19776033;19877275;19906846;19948480;19996169;20067783;20154143;20207148;20395968;20412786;20460306;20844016;20889716;20956384;2105456;21209331;21695114;21801010;21840926;22007132;22231273;22391300;23209152;23332756;23481700;23719536;24302888;24339784;24715725;24845016;24863049;24917297;24925320;24952464;25576301;25645385;27600516;28832583;28834231;29242379;29351928;29493099;30524438;31844290;32157095;32387766;32502341;32938616;33298915;33592498;33912179;34087483;34171305;35427153;35580925;36010968;38702430;39894887",
        "class_list": "",
        "function": "Biallelic loss of function variants in FUZ result in an orofaciodigital syndrome., [RefSeq, PubMed]; Data propose that mutations in Fuzzy may account for a subset of neural tube defects in humans. Erratum:[Hum Mol Genet. 2015 Jul 1;24(13):3893. doi: 10.1093/hmg/ddv131. PMID: 25954026], [RefSeq, PubMed]; Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia. Binds phosphatidylinositol 3-phosphate with highest affinity, followed by phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate (By similarity)., [UniProtKB, UniProtKB]; This gene encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement. Knockout studies in mice exhibit neural tube defects and defective cilia, and mutations in this gene are associated with neural tube defects in humans. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RD86;B5MDH0;Q6PJY0;Q9H613",
        "ec_number_list": "",
        "go_molecular_function": "GO:0035091 phosphatidylinositol binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005929 cilium;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0010172 embryonic body morphogenesis;GO:0090301 negative regulation of neural crest formation;GO:2000314 negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation;GO:0008285 negative regulation of cell population proliferation;GO:0015031 protein transport",
        "synthesized_glycan_count": 0,
        "hit_score": 9.7,
        "record_id": "Q9BT04-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P10075-1",
        "uniprot_id": "GLI4_HUMAN",
        "mass": 41145.0,
        "length": 376,
        "protein_name": "Zinc finger protein GLI4",
        "gene_name": "GLI4",
        "organism": "Human",
        "refseq_name": "zinc finger protein GLI4",
        "refseq_ac": "NP_612474",
        "gene_names_uniprotkb": "GLI4; HKR4",
        "gene_names_refseq": "GLI4; HKR4; ZNF928",
        "protein_names_uniprotkb": "Zinc finger protein GLI4; Krueppel-related zinc finger protein 4; Protein HKR4",
        "protein_names_refseq": "GLI-Kruppel family member GLI4 (oncogene HKR4); glioma-associated oncogene family zinc finger 4; krueppel-related zinc finger protein 4; zinc finger protein GLI4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2738)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "11237011;17081983;18669648;18691976;19369195;19413330;23186163;2850480;28904123;31217245;31844290;33298915",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96CK9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "P10075-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P09466-1",
        "uniprot_id": "PAEP_HUMAN",
        "mass": 20624.0,
        "length": 180,
        "protein_name": "Glycodelin",
        "gene_name": "PAEP",
        "organism": "Human",
        "refseq_name": "glycodelin isoform 2 precursor",
        "refseq_ac": "NP_001018058",
        "gene_names_uniprotkb": "PAEP",
        "gene_names_refseq": "GD; GdA; GdF; GdS; PAEG; PAEP; PEP; PP14; ZIF-1",
        "protein_names_uniprotkb": "Glycodelin; GD; PAEG; PEG; PP14; Placental protein 14; Pregnancy-associated endometrial alpha-2 globulin; Progestagen-associated endometrial protein; Progesterone-associated endometrial protein; ZIF-1; Zona-binding inhibitory factor-1",
        "protein_names_refseq": "PEG; PP14 protein (placental protein 14); alpha uterine protein; glycodelin isoform 2 precursor; glycodelin-A; glycodelin-F; glycodelin-S; pregnancy-associated endometrial alpha-2 globulin; progestagen-associated endometrial protein (placental protein 14, pregnancy-associated endometrial a; progesterone-associated endometrial protein; zona-binding inhibitory factor-1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5047)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "11237011;11278680;12672671;15883155;17192260;2006183;2206398;25422905;26791533;29557506;31730930;3194393;32120159;32205858;33388716;3569148;3667877;37074911;7531163;7592613;8943270;9239694;9918684",
        "class_list": "",
        "function": "Altered glycosylation of glycodelin in endometrial carcinoma., [RefSeq, PubMed]; Glycodelin is internalized by peripheral monocytes., [RefSeq, PubMed]; Glycodelin regulates the numbers and function of peripheral natural killer cells., [RefSeq, PubMed]; Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:7531163, PubMed:9918684). Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260). Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671). Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Pregnancy Zone Protein (PZP) is significantly upregulated in the decidua of recurrent and spontaneous miscarriage and negatively correlated to Glycodelin A (GdA)., [RefSeq, PubMed]; This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 42,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T6T1;Q9UG92",
        "ec_number_list": "",
        "go_molecular_function": "GO:0036094 small molecule binding",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0006915 apoptotic process;GO:1902491 negative regulation of sperm capacitation;GO:2000359 regulation of binding of sperm to zona pellucida;GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "P09466-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92947-1",
        "uniprot_id": "GCDH_HUMAN",
        "mass": 48127.0,
        "length": 438,
        "protein_name": "Glutaryl-CoA dehydrogenase, mitochondrial",
        "gene_name": "GCDH",
        "organism": "Human",
        "refseq_name": "glutaryl-CoA dehydrogenase, mitochondrial isoform a precursor",
        "refseq_ac": "NP_000150",
        "gene_names_uniprotkb": "GCDH",
        "gene_names_refseq": "ACAD5; GCDH; GCD",
        "protein_names_uniprotkb": "Glutaryl-CoA dehydrogenase, mitochondrial; 1.3.8.6; GCD",
        "protein_names_refseq": "glutaryl-CoA dehydrogenase, mitochondrial isoform a precursor; glutaryl-CoA dehydrogenase, mitochondrial; glutaryl-Coenzyme A dehydrogenase",
        "tax_id": 9606,
        "disease": "glutaric acidemia I (Disease Ontology:DOID:0111254)",
        "pathway": " (hsa:2639);  (R-HSA-71064)",
        "pathway_count": 2,
        "publication_count": 55,
        "publication_id_list": "10642506;10775527;11083877;11237011;12126930;1438360;14707522;15274622;16491085;17176108;17242435;18020372;18056995;18056996;18775954;19885858;20068231;22241472;24043460;24715725;24973495;25931162;26992070;29493099;29557506;30429286;31154438;31217245;31844290;32157095;32897882;32938616;33141586;33298915;33592498;33936100;33968037;34211107;34357683;34561969;34932366;35051231;35561310;35580925;36215666;37496092;37938771;38825017;6423663;6434529;8541831;8900227;8900228;9600243;9711871",
        "class_list": "",
        "function": "Biochemical and molecular features of chinese patients with glutaric acidemia type 1 from Fujian Province, southeastern China. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive., [UniProtKB, PubMed, PubMed, PubMed]; Glutaryl-CoA dehydrogenase suppresses tumor progression and shapes an anti-tumor microenvironment in hepatocellular carcinoma., [RefSeq, PubMed]; The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12. [provided by RefSeq, Mar 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2Z2;O14719",
        "ec_number_list": "1.3.8.6",
        "go_molecular_function": "GO:0004361 glutaryl-CoA dehydrogenase activity;GO:0050660 flavin adenine dinucleotide binding;GO:0000062 fatty-acyl-CoA binding;GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0046949 fatty-acyl-CoA biosynthetic process;GO:0006568 L-tryptophan metabolic process;GO:0033514 L-lysine catabolic process to acetyl-CoA via L-pipecolate",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "Q92947-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q969Y2-1",
        "uniprot_id": "GTPB3_HUMAN",
        "mass": 52058.0,
        "length": 492,
        "protein_name": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial",
        "gene_name": "GTPBP3",
        "organism": "Human",
        "refseq_name": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial isoform III",
        "refseq_ac": "NP_001122327",
        "gene_names_uniprotkb": "GTPBP3; MTGP1",
        "gene_names_refseq": "COXPD23; GTPBG3; GTPBP3; MSS1; MTGP1; THDF1",
        "protein_names_uniprotkb": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial; 3.6.1.-; GTP-binding protein 3; Mitochondrial GTP-binding protein 1; tRNA modification GTPase GTPBP3, mitochondrial",
        "protein_names_refseq": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial isoform III; 5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial; mitochondrial GTP-binding protein 1; tRNA modification GTPase GTPBP3, mitochondrial",
        "tax_id": 9606,
        "disease": "combined oxidative phosphorylation deficiency 23 (Disease Ontology:DOID:0111500); aminoglycoside-induced deafness (Disease Ontology:DOID:0111734); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); mitochondrial metabolism disease (Disease Ontology:DOID:700)",
        "pathway": " (hsa:84705);  (R-HSA-6787450)",
        "pathway_count": 2,
        "publication_count": 44,
        "publication_id_list": "11237011;12370316;12456664;15509579;15542390;16826519;18852288;19732863;21890497;22608499;23042678;23097428;23301498;23481700;23625533;23814040;23929671;24126054;24715725;24901367;25434004;25552653;25925575;26741492;27846572;27920218;29242379;29390138;29557506;29760464;31844290;32047918;32357974;32488085;32897882;32938616;33298915;33392160;33592498;33619562;33968037;36980825;37217939;9512533",
        "class_list": "",
        "function": "Data show that the two most abundant GTPBP3 isoforms exhibit moderate affinity for guanine nucleotides like their bacterial homologue, MnmE, although they hydrolyze GTP at a 100-fold lower rate., [RefSeq, PubMed]; GTPBP3 localizes in the mitochondria and is a deafness-associated homolog of yeast MSS1., [RefSeq, PubMed]; GTPase component of the GTPBP3-MTO1 complex that catalyzes the 5-taurinomethyluridine (taum(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs (mt-tRNAs), which plays a role in mt-tRNA decoding and mitochondrial translation (PubMed:29390138, PubMed:33619562). Taum(5)U formation on mammalian mt-tRNA requires the presence of both GTPBP3-mediated GTPase activity and MTO1 catalytic activity (PubMed:29390138)., [UniProtKB, PubMed, PubMed]; Pathogenicity Analysis of a Novel Variant in GTPBP3 Causing Mitochondrial Disease and Systematic Literature Review. Publication Status: Online-Only, [RefSeq, PubMed]; Phenotype of non-syndromic deafness associated with the mitochondrial A1555G mutation is modulated by mitochondrial RNA modifying enzymes MTO1 and GTPBP3., [RefSeq, PubMed]; The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases., [RefSeq, PubMed]; This locus encodes a GTP-binding protein. The encoded protein is localized to the mitochondria and may play a role in mitochondrial tRNA modification. Polymorphisms at this locus may be associated with severity of aminoglycoside-induced deafness, a disease associated with a mutation in the 12S rRNA. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NFH1;A6NIG5;A6NKR4;A8K7B4;B7Z4V8;Q8TCY6;Q8WUW9;Q969G4;Q9BX61",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.1.-;3.6.5.4;2.7.11.1;3.6.-.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:7770010 GTPBP3-MTO1 complex",
        "go_biological_process": "GO:0002098 tRNA wobble uridine modification;GO:0030488 tRNA methylation;GO:0070899 mitochondrial tRNA wobble uridine modification;GO:0008033 tRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "Q969Y2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P19878-1",
        "uniprot_id": "NCF2_HUMAN",
        "mass": 59762.0,
        "length": 526,
        "protein_name": "Neutrophil cytosol factor 2",
        "gene_name": "NCF2",
        "organism": "Human",
        "refseq_name": "neutrophil cytosol factor 2 isoform 1",
        "refseq_ac": "NP_000424",
        "gene_names_uniprotkb": "NCF2; NOXA2; P67PHOX",
        "gene_names_refseq": "NCF-2; NCF2; NOXA2; P67-PHOX; P67PHOX",
        "protein_names_uniprotkb": "Neutrophil cytosol factor 2; 67 kDa neutrophil oxidase factor; NADPH oxidase activator 2; NCF-2; Neutrophil NADPH oxidase factor 2; p67-phox",
        "protein_names_refseq": "67 kDa neutrophil oxidase factor; NADPH oxidase activator 2; neutrophil NADPH oxidase factor 2; neutrophil cytosol factor 2 isoform 1; neutrophil cytosol factor 2; neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2)",
        "tax_id": 9606,
        "disease": "renal fibrosis (Disease Ontology:DOID:0050855); autosomal recessive chronic granulomatous disease 2 (Disease Ontology:DOID:0070191); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); status epilepticus (Disease Ontology:DOID:1824); proteinuria (Disease Ontology:DOID:576); rheumatoid arthritis (Disease Ontology:DOID:7148); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:4688);  (R-HSA-1222556);  (R-HSA-1236973);  (R-HSA-3299685);  (R-HSA-4420097);  (R-HSA-5668599);  (R-HSA-9013149);  (R-HSA-9013404);  (R-HSA-9013423)",
        "pathway_count": 9,
        "publication_count": 481,
        "publication_id_list": "10029572;10037737;10072071;10075701;10207622;10232922;10358769;10395673;10400704;10455184;10464238;10490598;10498624;10508610;10514471;10521424;10523665;10523675;10526156;10559246;10579713;10598813;10618392;10656833;10677529;10692392;10699171;10699464;10744763;10749680;10833429;10847683;10873802;10919671;10958683;10982;11007481;11018045;11058585;11085924;11090627;11112388;11139407;11145705;11149925;11237011;11237855;11278486;11278853;11373293;11396949;11431473;11432776;11507097;11518528;11584276;11672528;11695992;11696015;11704860;11707441;11756552;11773441;11803464;11804587;11804589;11804590;11884391;11886899;11912491;11912930;11919634;11956649;11961559;11970843;12056906;12071859;12093360;12096337;12134158;12169629;12195014;12207919;12214271;12215529;12221096;12351724;12391143;12432077;12446202;12464388;12531887;12546821;12547822;12650940;12660731;12665586;12716910;12810700;12820653;12829378;12857875;12877655;12887891;12923183;14512443;14514689;14530365;1464587;14675773;14718541;14724572;15023524;15026417;15033976;15044467;15046979;15064355;15064408;15107133;15133129;15147912;15169870;15247219;15280035;15302923;15308668;15317809;15339924;15342493;15485661;15507211;15542837;15579468;15591124;15596429;15601624;15611138;15642721;15688067;15695828;15728722;15814684;15824103;15850391;15858067;15897194;15927447;15962004;16002401;16081809;16112081;16116428;16184169;16243035;16243036;16329988;16336962;16401067;16473593;16492808;16507994;16519628;1660188;16615992;16636067;1668270;16702231;16750198;16760434;16762923;16777452;16777849;16778989;16862148;16880213;16896804;16914516;1692159;16937026;16966330;16968698;17030947;17060455;17077126;17145773;17158234;17196961;17199126;17214551;17237347;17244649;17269730;17275676;17290225;17293873;17351642;17519234;17583407;17599059;1763037;17662945;17686471;17698854;17702745;17707404;17765681;17804252;17976533;18006505;18045877;18056264;18191593;18218625;18249095;18268517;18331591;18347018;18358825;18396277;18426980;18625437;18653540;18662984;18682599;18697831;18703498;18838382;18936159;19089323;19217269;19219623;19230644;19267251;19269969;19372727;19494238;19534724;19542232;19605563;19624736;19673492;19713215;19934221;1999334;20058876;20070187;20134026;20167518;20171863;20367259;20400958;20460433;20658524;20679435;20690882;2071038;20810653;20813901;20956805;21124855;21148482;21151158;21215271;21239714;21378159;21385867;21393238;21445309;21542010;21565175;21613211;21730051;21865595;21967640;21989057;22004470;22096251;22298643;22327215;22407364;22424782;22475431;22493009;22608513;22689825;22734669;22808130;22869735;22910329;22970203;23152058;23164639;23209303;23216836;23255595;23288169;23289851;23434736;23454490;23455484;23481700;23572525;23707487;23718289;23757206;23870057;23875749;23910690;23940355;23980663;24086303;24259668;24335996;24352656;24366607;24623723;24859002;24933155;24960694;25024229;25047527;25211221;25428919;25502872;25576301;25704760;25721503;25795300;25862245;25877926;25892735;26016997;26129894;26154972;26529257;26628301;26887924;27117132;27145964;27216196;27481945;27535533;27543614;27555588;27558335;27566826;27713499;27806292;27846572;27862975;27920218;28114311;28196833;28228285;2825632;28356423;2848506;28514659;28832583;28904123;29089502;29242379;29358323;29382922;29508533;29557506;29769354;29786170;30315122;30410026;30853411;31154438;31389670;31530632;31611695;31844290;31848261;31871319;32203420;32357974;32387766;32502341;32983136;33141586;33298915;33392160;33691108;33717175;33912179;33968037;34171305;34211107;34357683;3457020;35051231;3532102;35580925;3619451;36284347;36581221;3693360;37217939;37612524;38355798;38563173;38654426;5389100;60;6286671;6961438;7021796;7172448;7479768;7487923;7509446;7512369;7559638;7673236;7678924;7721814;7753201;7835339;7903171;7980580;8021274;807573;8089108;8107774;8280052;8286749;8379940;8428933;8452552;8537108;8537347;8543060;8617235;8643598;8645157;8662891;8663465;8756646;8769096;8798539;8805223;8810315;8816443;8939998;8986718;8990121;8994827;9013646;9070911;9099726;9113980;9182576;9252344;9295278;9305890;9369223;9393975;9398617;9438849;9472046;9490638;9497316;9582072;9639555;9659915;9670022;9705280;9726962;9763615;9792683;9804763;9822598;9843499;9923614;9931304;9988689",
        "class_list": "",
        "function": "Clinical and molecular significance of flow cytometric analysis for reactive oxygen species production and residual p67[phox] expression in p67[phox]-deficient chronic granulomatous disease., [RefSeq, PubMed]; M6A-mediated-upregulation of lncRNA BLACAT3 promotes bladder cancer angiogenesis and hematogenous metastasis through YBX3 nuclear shuttling and enhancing NCF2 transcription. Erratum:[Oncogene. 2025 Oct;44(40):3879-3882. doi: 10.1038/s41388-025-03575-x. PMID: 40962859], [RefSeq, PubMed]; Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:12207919, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]., [RefSeq]; [Correlation study of NCF2 in chronic rhinosinusitis with nasal polyps]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6Q1;B4DKQ7;B4DQA7;E9PHJ2;E9PHX3;Q2PP06;Q8NFC7;Q9BV51",
        "ec_number_list": "",
        "go_molecular_function": "GO:0009055 electron transfer activity;GO:0031267 small GTPase binding;GO:0016176 superoxide-generating NADPH oxidase activator activity;GO:0016175 superoxide-generating NAD(P)H oxidase activity",
        "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032010 phagolysosome",
        "go_biological_process": "GO:0045087 innate immune response;GO:0006909 phagocytosis;GO:0006968 cellular defense response;GO:0045730 respiratory burst;GO:0006801 superoxide metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 48.4,
        "record_id": "P19878-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q99435-1",
        "uniprot_id": "NELL2_HUMAN",
        "mass": 91346.0,
        "length": 816,
        "protein_name": "Protein kinase C-binding protein NELL2",
        "gene_name": "NELL2",
        "organism": "Human",
        "refseq_name": "protein kinase C-binding protein NELL2 isoform a",
        "refseq_ac": "NP_001138579",
        "gene_names_uniprotkb": "NELL2; NRP2",
        "gene_names_refseq": "NELL2; NRP2",
        "protein_names_uniprotkb": "Protein kinase C-binding protein NELL2; NEL-like protein 2; Nel-related protein 2",
        "protein_names_refseq": "NEL-like protein 2; NEL-related protein 2; neural epidermal growth factor-like 2; protein kinase C-binding protein NELL2 isoform a; protein kinase C-binding protein NELL2",
        "tax_id": 9606,
        "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)",
        "pathway": " (hsa:4753);  (R-HSA-428542)",
        "pathway_count": 2,
        "publication_count": 20,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;15340161;24190977;24936616;26586761;29237092;29242379;29493099;29557506;32198364;34195782;34238763;34411563;35051231;35318648;35940226;37217939;38665916;8975702",
        "class_list": "",
        "function": "Anoctamin 5 promotes osteosarcoma development by increasing degradation of Nel-like proteins 1 and 2., [RefSeq, PubMed]; Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding., [RefSeq, PubMed]; Epididymal-secreted protein that signals through a ROS1-pathway to regulate the epididymal initial segment (IS) maturation, sperm maturation and male fertility., [UniProtKB, UniProtKB]; NELL2 modulates cell proliferation and apoptosis via ERK pathway in the development of benign prostatic hyperplasia., [RefSeq, PubMed]; Plays multiple roles in neural tissues, regulates neuronal proliferation, survival, differentiation, polarization, as well as axon guidance and synaptic functions. Plays an important role in axon development during neuronal differentiation through the MAPK intracellular signaling pathway (By similarity). Via binding to its receptor ROBO3, plays a role in axon guidance, functioning as a repulsive axon guidance cue that contributes to commissural axon guidance to the midline (PubMed:32198364). Required for neuron survival through the modulation of MAPK signaling pathways too. Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity)., [UniProtKB, UniProtKB, PubMed]; The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis. [provided by RefSeq, Feb 2009]., [RefSeq]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 46,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 1,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z2U7;B7Z5Q4;B7Z9J5;B7Z9U3;Q96JS2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0005080 protein kinase C binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0009566 fertilization;GO:0070050 neuron cellular homeostasis;GO:0071679 commissural neuron axon guidance",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "Q99435-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60234-1",
        "uniprot_id": "GMFG_HUMAN",
        "mass": 16801.0,
        "length": 142,
        "protein_name": "Glia maturation factor gamma",
        "gene_name": "GMFG",
        "organism": "Human",
        "refseq_name": "glia maturation factor gamma isoform 2",
        "refseq_ac": "NP_001287937",
        "gene_names_uniprotkb": "GMFG",
        "gene_names_refseq": "GMF-GAMMA; GMFG",
        "protein_names_uniprotkb": "Glia maturation factor gamma; GMF-gamma",
        "protein_names_refseq": "glia maturation factor gamma isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9535);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 58,
        "publication_id_list": "10541589;11237011;17697703;19608861;23650620;24714562;24715725;24818551;25418920;26154972;26758079;26992070;27397612;27846572;27920218;28228285;28514659;28832583;28904123;29242379;29393594;29493099;29508533;29557506;29786170;30315122;30410026;30811945;31844290;32157095;32350084;32357974;32387766;32502341;32897882;32983136;33123756;33141586;33298915;33392160;33592498;33691108;33717175;33863293;33912179;34509645;34932366;35051231;35103856;35383531;35561310;35580925;36284347;37372337;37938771;8692836;9545571;9653160",
        "class_list": "",
        "function": "Bioinformatics and survival analysis of glia maturation factor-gamma in pan-cancers. Publication Status: Online-Only, [RefSeq, PubMed]; GMFG (glia maturation factor gamma) inhibits lung cancer growth by activating p53 signaling pathway., [RefSeq, PubMed]; GMFgamma phosphorylation by c-Abl has an important role in coordinating lamellipodial and focal adhesion dynamics to regulate cell migration, [RefSeq, PubMed]; High Level of GMFG Correlated to Poor Clinical Outcome and Promoted Cell Migration and Invasion through EMT Pathway in Triple-Negative Breast Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; RNF144A exerts tumor suppressor function in breast cancer through targeting YY1 for proteasomal degradation to downregulate GMFG expression. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IB37",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0008047 enzyme activator activity;GO:0004860 protein kinase inhibitor activity;GO:0008083 growth factor activity;GO:0071933 Arp2/3 complex binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0034774 secretory granule lumen;GO:1904813 ficolin-1-rich granule lumen;GO:0030864 cortical actin cytoskeleton;GO:0005634 nucleus",
        "go_biological_process": "GO:0071846 actin filament debranching;GO:0006468 protein phosphorylation;GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "O60234-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UF11-1",
        "uniprot_id": "PKHB1_HUMAN",
        "mass": 27186.0,
        "length": 243,
        "protein_name": "Pleckstrin homology domain-containing family B member 1",
        "gene_name": "PLEKHB1",
        "organism": "Human",
        "refseq_name": "pleckstrin homology domain-containing family B member 1 isoform c",
        "refseq_ac": "NP_001123505",
        "gene_names_uniprotkb": "PLEKHB1; EVT1; KPL1; PHR1; PHRET1",
        "gene_names_refseq": "KPL1; PHR1; PHRET1; PLEKHB1",
        "protein_names_uniprotkb": "Pleckstrin homology domain-containing family B member 1; Evectin-1; PH domain-containing family B member 1; PH domain-containing protein in retina 1; PHRET1; Pleckstrin homology domain retinal protein 1",
        "protein_names_refseq": "PH domain containing, retinal 1; PH domain-containing family B member 1; PH domain-containing protein in retina 1; evectin-1; pleckstrin homology domain containing, family B (evectins) member 1; pleckstrin homology domain retinal protein 1; pleckstrin homology domain-containing family B member 1 isoform c; pleckstrin homology domain-containing family B member 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:58473)",
        "pathway_count": 1,
        "publication_count": 22,
        "publication_id_list": "10585447;10923244;11237011;19913121;20301200;24715725;26154972;26318175;26375851;26992070;28218747;28834231;29557506;31154438;31844290;32157095;32488085;32983136;33912179;35051231;35580925;36284347",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Phr1 is widely and abundantly expressed throughout mature olfactory neurons and other primary sensory neurons, but its absence does not appear to affect olfactory morphology, regeneration, sensory function, or adaptation., [RefSeq, PubMed]; The human PHR1, a PH domain-containing protein with low expression in the heart and high expression in the brain, interacts with coxsackievirus B3 VP1, a major structural protein of coxsackievirus B3., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K0Q5;B2RBP1;B7Z716;Q9UBF5;Q9UI37;Q9UI44",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane",
        "go_biological_process": "GO:0045595 regulation of cell differentiation;GO:0007602 phototransduction",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q9UF11-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q68CQ7-1",
        "uniprot_id": "GL8D1_HUMAN",
        "mass": 41935.0,
        "length": 371,
        "protein_name": "Glycosyltransferase 8 domain-containing protein 1",
        "gene_name": "GLT8D1",
        "organism": "Human",
        "refseq_name": "glycosyltransferase 8 domain-containing protein 1",
        "refseq_ac": "NP_001010983",
        "gene_names_uniprotkb": "GLT8D1; AD-017; GALA4A; MSTP137; PRO1134",
        "gene_names_refseq": "AD-017; GLT8D1; MSTP139",
        "protein_names_uniprotkb": "Glycosyltransferase 8 domain-containing protein 1; 2.4.1.-",
        "protein_names_refseq": "glycosyltransferase 8 domain-containing protein 1; glycosyltransferase AD-017",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55830)",
        "pathway_count": 1,
        "publication_count": 63,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10931946;11237011;12975309;19159218;20112406;22299025;22461910;23090970;23584533;24190977;25418920;25502872;25548167;27090790;27846572;27920218;28228285;28467828;28904123;29242379;29314611;29351928;29557506;29632046;29632711;29741879;29774024;30315122;30429286;30573663;31020640;31611695;31844290;32157095;32350084;32357974;32387766;32938616;32983136;33043033;33581934;33592498;33714647;33912179;33936100;33963205;33968037;34171305;34357683;34433824;34746377;34932366;35051231;35154160;35251023;36010968;36241641;37074911;37277853;38066107;40596516",
        "class_list": "glycogene;glycosyltransferase",
        "function": "GLT8D1 may not be significant in Chinese sporadic amyotrophic lateral sclerosis patients., [RefSeq, PubMed]; GLT8D1 was found to be differentially methylated and differentially expressed in human squamous cell carcinomas., [RefSeq, PubMed]; Genetic analysis of GLT8D1 and ARPP21 in Australian familial and sporadic amyotrophic lateral sclerosis., [RefSeq, PubMed]; Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a patient with a glomangiopericytal tumor and five different sarcomas over a 10-year period. Publication Status: Online-Only, [RefSeq, PubMed]; Glycosyltransferase 8 domain-containing protein 1 (GLT8D1) is a UDP-dependent galactosyltransferase. Publication Status: Online-Only, [RefSeq, PubMed]; Glycosyltransferase GLT8D1 and GLT8D2 serve as potential prognostic biomarkers correlated with Tumor Immunity in Gastric Cancer. Erratum:[BMC Med Genomics. 2023 Jun 16;16(1):136. doi: 10.1186/s12920-023-01578-9. PMID: 37328741] Publication Status: Online-Only, [RefSeq, PubMed]; In vitro, catalyzes the transfer of a galactose residue from UDP-galactose onto GalNAc and GlcNAc structures., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes a member of the glycosyltransferase family. The specific function of this protein has not been determined. Alternative splicing results in multiple transcript variants of this gene [provided by RefSeq, May 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 385,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 14,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7Z4D1;Q8N2J6;Q9P0I5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 8.6,
        "record_id": "Q68CQ7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P14314-1",
        "uniprot_id": "GLU2B_HUMAN",
        "mass": 59425.0,
        "length": 528,
        "protein_name": "Glucosidase 2 subunit beta",
        "gene_name": "PRKCSH",
        "organism": "Human",
        "refseq_name": "glucosidase 2 subunit beta isoform 2 precursor",
        "refseq_ac": "NP_001001329",
        "gene_names_uniprotkb": "PRKCSH; G19P1",
        "gene_names_refseq": "80K-H; AGE-R2; G19P1; GIIB; GIIbeta; GluIIbeta; PCLD1; PCLD; PKCSH; PLD1; PRKCSH; VASAP-60",
        "protein_names_uniprotkb": "Glucosidase 2 subunit beta; 80K-H protein; Glucosidase II subunit beta; PKCSH; Protein kinase C substrate 60.1 kDa protein heavy chain",
        "protein_names_refseq": "AGE-binding receptor 2; advanced glycation end-product receptor 2; glucosidase 2 subunit beta isoform 2 precursor; glucosidase 2 subunit beta; glucosidase II subunit beta; hepatocystin; protein kinase C substrate 60.1 kDa protein heavy chain; protein kinase C substrate 80K-H; protein kinase C substrate, 80 Kda protein",
        "tax_id": 9606,
        "disease": "polycystic liver disease (Disease Ontology:DOID:0050770); polycystic liver disease 1 (Disease Ontology:DOID:0060980); liver disease (Disease Ontology:DOID:409)",
        "pathway": " (hsa:5589);  (R-HSA-381426);  (R-HSA-532668);  (R-HSA-879415);  (R-HSA-8957275);  (R-HSA-901042);  (R-HSA-9683686);  (R-HSA-9694548);  (R-HSA-9768727)",
        "pathway_count": 9,
        "publication_count": 183,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10026136;10077652;10218588;10512690;10531386;10614670;10681634;10788335;10810289;10898936;10912521;10929008;10951195;10990447;11047756;11158056;11237011;11250653;11264294;11316783;11522292;11606061;11739083;11751371;11788658;12114544;12145188;12241545;12379487;12466191;12470955;12529853;12577059;12665801;12810533;12904166;12935895;1370451;1383255;15126567;15215856;15308688;15358861;15362974;15469690;15485880;15525596;15642270;16055502;16168377;1651976;16940051;17047378;17249697;17261850;17312271;17507649;17985932;18491227;18524852;20129637;21654843;22375065;22661428;22915798;23090970;23301498;23584533;24190977;24681004;2476804;2479552;24966173;25128556;25348530;25502872;25576301;25813380;26091039;26365003;26416966;26611529;26853435;26992070;27114449;27255086;2793184;28218747;28228285;28375157;28467828;28512129;28973524;29038287;29237092;29242379;29314611;29351928;29493099;29557506;29632711;29741879;29786170;30192525;30459171;31217245;31611695;31844290;32119511;32157095;32350084;32363391;32366695;32488085;32502341;32518941;32676595;32938616;32983136;33214551;33310888;33392160;33592498;33912179;33936100;33968037;34019948;34078123;34105348;34117209;34171305;34357683;34428449;34433824;34528721;34599882;34725712;34961524;35051231;35132862;35251023;35254362;35289036;35580925;36240223;36241641;36284347;37074911;37340703;38245572;38665916;38838015;39534244;40914422;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7683646;7689487;7876246;7982500;7986008;8102790;8529130;8781553;8817670;8894645;8964575;9043864;9497324;9709957;9733769;9786878;9922210",
        "class_list": "glycogene",
        "function": "PRKCSH serves as a potential immunological and prognostic biomarker in pan-cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Potential role of PRKCSH in lung cancer: bioinformatics analysis and a case study of Nano ZnO. Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Results suggest that loss of PRKCSH and SEC63 leads to general defects in ciliogenesis, while quenching of the Wnt signaling cascade is cholangiocyte-restricted., [RefSeq, PubMed]; This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]., [RefSeq]; This study demonstrated that Large copy number variations on germline level are not present in patients with a clinical diagnosis of Severe Polycystic Liver Disease., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 11,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 11,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 11,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 700,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 31,
        "disease_count": 3,
        "glyco_site_count": 15,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K318;Q96BU9;Q96D06;Q9P0W9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0051219 phosphoprotein binding;GO:0005080 protein kinase C binding;GO:0005509 calcium ion binding;GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0043231 intracellular membrane-bounded organelle;GO:0017177 glucosidase II complex",
        "go_biological_process": "GO:0001889 liver development;GO:0035556 intracellular signal transduction;GO:0006491 N-glycan processing",
        "synthesized_glycan_count": 0,
        "hit_score": 23.0,
        "record_id": "P14314-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A6NI86-1",
        "uniprot_id": "GG6LA_HUMAN",
        "mass": 60902.0,
        "length": 522,
        "protein_name": "Golgin subfamily A member 6-like protein 10",
        "gene_name": "GOLGA6L10",
        "organism": "Human",
        "refseq_name": "golgin subfamily A member 6-like protein 10 isoform 1",
        "refseq_ac": "NP_001157937",
        "gene_names_uniprotkb": "GOLGA6L10; GOLGA6L18",
        "gene_names_refseq": "GOLGA6L10; GOLGA6L18",
        "protein_names_uniprotkb": "Golgin subfamily A member 6-like protein 10",
        "protein_names_refseq": "golgi autoantigen, golgin subfamily a, 6-like 10; golgin A6 family-like 18; golgin subfamily A member 6-like protein 10 isoform 1; putative golgin subfamily A member 6-like protein 10",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:647042)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;28121444",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 9901,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A087WVD5;D6RB28",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A6NI86-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P51114-1",
        "uniprot_id": "FXR1_HUMAN",
        "mass": 69721.0,
        "length": 621,
        "protein_name": "RNA-binding protein FXR1",
        "gene_name": "FXR1",
        "organism": "Human",
        "refseq_name": "RNA-binding protein FXR1 isoform b",
        "refseq_ac": "NP_001013456",
        "gene_names_uniprotkb": "FXR1",
        "gene_names_refseq": "CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P; FXR1; MYOPMIL; MYORIBF",
        "protein_names_uniprotkb": "RNA-binding protein FXR1; FMR1 autosomal homolog 1; hFXR1p",
        "protein_names_refseq": "FMR1 autosomal protein-like protein 1; RNA-binding protein FXR1 isoform b; RNA-binding protein FXR1",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); congenital myopathy 9A (Disease Ontology:DOID:0081343); congenital myopathy 9B (Disease Ontology:DOID:0081344); fragile X syndrome (Disease Ontology:DOID:14261); glucose metabolism disease (Disease Ontology:DOID:4194); malignant pleural mesothelioma (Disease Ontology:DOID:7474)",
        "pathway": " (hsa:8087);  (R-HSA-6802952)",
        "pathway_count": 2,
        "publication_count": 131,
        "publication_id_list": "11157796;11237011;14532325;15630448;16959974;17081983;17382880;18452278;18664458;18669648;18691976;18974108;19413330;19651622;19664995;19690332;20068231;20417602;20526349;21072162;21406692;21424530;21771594;22121020;22745804;23186163;23301498;23481700;23583981;24135138;24345920;24366607;24714562;24958902;25204415;25225333;25576301;25645385;25810538;25892735;25907612;26154972;26375851;26992070;27397612;27509095;27600516;27846572;27862975;28228285;28510447;28514659;28649982;28832583;28834231;28855257;28904123;29142209;29242379;29331515;29393594;29493099;29557506;29632046;29632711;29769354;29786170;29789417;30059200;30067974;30315122;30429286;30484775;30524438;30770808;30779550;30833945;31154438;31217245;31530632;31844290;31848261;31998317;32157095;32350084;32357974;32387766;32488085;32502341;32706158;32897882;32938616;32983136;33214551;33592498;33633747;33691108;33717175;33936100;33968037;33981976;34019948;34087483;34171305;34229054;34357683;34725712;34731628;34932366;35051231;35083852;35154160;35318648;35580925;35989368;36010968;36215666;36241641;36284347;36306353;37217939;37938771;38238286;38587486;39106863;40596516;40914422;7489725;7781595;8668200;9259278",
        "class_list": "",
        "function": "LLPS of FXR proteins drives replication organelle clustering for beta-coronaviral proliferation., [RefSeq, PubMed]; The FXR1 network acts as a signaling scaffold for actomyosin remodeling., [RefSeq, PubMed]; The multifaceted role of Fragile X-Related Protein 1 (FXR1) in cellular processes: an updated review on cancer and clinical applications. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 22,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K9B8;Q7Z450;Q8N6R8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0042803 protein homodimerization activity;GO:0043021 ribonucleoprotein complex binding;GO:0046982 protein heterodimerization activity;GO:0003730 mRNA 3'-UTR binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005730 nucleolus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0060538 skeletal muscle organ development;GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:1900272 negative regulation of long-term synaptic potentiation;GO:0006915 apoptotic process;GO:0032720 negative regulation of tumor necrosis factor production",
        "synthesized_glycan_count": 0,
        "hit_score": 13.4,
        "record_id": "P51114-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P52306-1",
        "uniprot_id": "GDS1_HUMAN",
        "mass": 66317.0,
        "length": 607,
        "protein_name": "Rap1 GTPase-GDP dissociation stimulator 1",
        "gene_name": "RAP1GDS1",
        "organism": "Human",
        "refseq_name": "rap1 GTPase-GDP dissociation stimulator 1 isoform 1",
        "refseq_ac": "NP_001093896",
        "gene_names_uniprotkb": "RAP1GDS1; SMGGDS",
        "gene_names_refseq": "GDS1; RAP1GDS1; SmgGDS",
        "protein_names_uniprotkb": "Rap1 GTPase-GDP dissociation stimulator 1; Exchange factor smgGDS; SMG GDS protein; SMG P21 stimulatory GDP/GTP exchange protein",
        "protein_names_refseq": "RAP1, GTP-GDP dissociation stimulator 1; SMG GDS protein; SMG P21 stimulatory GDP/GTP exchange protein; exchange factor smgGDS; rap1 GTPase-GDP dissociation stimulator 1 isoform 1",
        "tax_id": 9606,
        "disease": "Alfadhel syndrome (MONDO:MONDO:0958001)",
        "pathway": " (hsa:5910);  (R-HSA-9013419);  (R-HSA-9013425)",
        "pathway_count": 3,
        "publication_count": 87,
        "publication_id_list": "10477737;10929031;11237011;11948427;12551911;1549351;16419055;16630562;19103291;19608861;20709748;21242305;22544926;22706990;23301498;23481700;24349085;24415755;24714562;24715725;25576301;25645385;26154972;26375851;26754738;26768311;26992070;27716788;27846572;27862975;28218747;28228285;28514659;28630045;28832583;28834231;28904123;29242379;29437277;29508533;29557506;29694881;29786170;30111583;30190425;30429286;30484775;30513825;30524438;30779550;31217245;31406347;31479585;31844290;32157095;32350084;32387766;32431071;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33633747;33875846;33936100;33968037;33981976;34087483;34171305;34357683;34509645;35051231;35254053;35318648;35526384;35561310;35580925;36010968;36241641;36284347;37938771;40596516;40914422",
        "class_list": "",
        "function": "Acts as a GEF (guanine nucleotide exchange factor) for prenylated RHOA (PubMed:21242305, PubMed:28630045, PubMed:30190425). Acts as a GEF for RHOC (PubMed:21242305). Chaperones the downstream trafficking and/or processing of small newly prenylated GTPases (PubMed:20709748). Escorts RAC1 to the nucleus (PubMed:12551911)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP (PubMed:11948427, PubMed:1549351, PubMed:20709748, PubMed:28630045, PubMed:30190425). Additionally, appears to chaperone the processing and/or trafficking of small GTPases containing a C-terminal polybasic region independently of GEF activity (PubMed:20709748, PubMed:21242305). Targets include RAP1A/RAP1B, RHOA, RHOB, RHOC, RAC1 and KRAS (PubMed:11948427, PubMed:1549351, PubMed:20709748, PubMed:24415755). Regulates mitochondrial dynamics by controlling RHOT function to promote mitochondrial fission during high calcium conditions (PubMed:27716788). Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake (PubMed:24349085)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Acts as a GEF (guanine nucleotide exchange factor) for unprenylated RHOA (PubMed:24415755, PubMed:28630045, PubMed:30190425). Chaperones the entry and passage of small GTPases through the prenylation pathway (PubMed:20709748). Recognizes the last amino acid in the GTPase C-terminal CAAX motif with a preference for 'Leu' over 'Met', indicating involvement in the geranylgeranylation pathway (PubMed:24415755)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PH06;G5E9P9;Q499L7;Q4KMV2;Q4QQI8;Q9BUW9;Q9BUX6;Q9NYM2;Q9NZA8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0031034 myosin filament assembly;GO:0014829 vascular associated smooth muscle contraction;GO:0034504 protein localization to nucleus;GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration;GO:0010821 regulation of mitochondrion organization",
        "synthesized_glycan_count": 0,
        "hit_score": 9.0,
        "record_id": "P52306-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P21217-1",
        "uniprot_id": "FUT3_HUMAN",
        "mass": 42117.0,
        "length": 361,
        "protein_name": "3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3",
        "gene_name": "FUT3",
        "organism": "Human",
        "refseq_name": "3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3",
        "refseq_ac": "NP_000140",
        "gene_names_uniprotkb": "FUT3; FT3B; LE",
        "gene_names_refseq": "CD174; FT3B; FUT3; FucT-III; LE; Les",
        "protein_names_uniprotkb": "3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3; 2.4.1.-; 2.4.1.152; 2.4.1.65; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase; Alpha-3-fucosyltransferase FUT3; Blood group Lewis alpha-4-fucosyltransferase; FucT-III; Fucosyltransferase 3; Fucosyltransferase III; Lewis FT",
        "protein_names_refseq": "3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase 3; 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase; Lewis FT; alpha-(1,3/1,4)-fucosyltransferase; alpha-3-fucosyltransferase FUT3; blood group Lewis alpha-4-fucosyltransferase; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); fucosyltransferase III",
        "tax_id": 9606,
        "disease": "candidiasis (Disease Ontology:DOID:1508); obsolete blood group, lewis system (MONDO:MONDO:0033552)",
        "pathway": " (hsa:2525);  (R-HSA-9037629);  (R-HSA-975578)",
        "pathway_count": 3,
        "publication_count": 60,
        "publication_id_list": "10094192;10206952;10211701;10212226;10343104;10464296;10814706;10988254;10988300;11058871;11237011;11445554;12107078;12222957;12417412;12527108;12668675;12678917;14688233;15158662;1520296;16754854;1702034;17123352;1716630;17175120;1740457;17466984;18431515;1977660;23090970;24190977;24953560;27453266;29593094;36335265;37342060;37946130;39108208;7635144;7650030;7721776;7876235;7961897;8063716;8207002;8219240;8240322;8240337;8288606;8333853;8524845;8801770;8808595;9219535;9268337;9478973;9582303;9703429;9949196",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to both the subterminal N-acetyl glucosamine (GlcNAc) of type 1 chain (beta-D-Gal-(1->3)-beta-D-GlcNAc) glycolipids and oligosaccharides via an alpha(1,4) linkage, and the subterminal glucose (Glc) or GlcNAc of type 2 chain (beta-D-Gal-(1->4)-beta-D-GlcNAc) oligosaccharides via an alpha(1,3) linkage, independently of the presence of terminal alpha-L-fucosyl-(1,2) moieties on the terminal galactose of these acceptors (PubMed:11058871, PubMed:12668675, PubMed:1977660). Through its catalytic activity, participates in the synthesis of antigens of the Lewis blood group system, i.e. Lewis a (Le(a)), lewis b (Le(b)), Lewis x/SSEA-1 (Le(x)) and lewis y (Le(y)) antigens (PubMed:11058871, PubMed:12668675, PubMed:1977660). Also catalyzes the transfer of L-fucose to subterminal GlcNAc of sialyl- and disialyl-lactotetraosylceramide to produce sialyl Lewis a (sLe(a)) and disialyl Lewis a via an alpha(1,4) linkage and therefore may regulate cell surface sLe(a) expression and consequently regulates adhesive properties to E-selectin, cell proliferation and migration (PubMed:11058871, PubMed:12668675, PubMed:27453266). Catalyzes the transfer of an L-fucose to 3'-sialyl-N-acetyllactosamine by an alpha(1,3) linkage, which allows the formation of sialyl-Lewis x structure and therefore may regulate the sialyl-Lewis x surface antigen expression and consequently adhesive properties to E-selectin (PubMed:11058871, PubMed:29593094). Prefers type 1 chain over type 2 acceptors (PubMed:7721776). Type 1 tetrasaccharide is a better acceptor than type 1 disaccharide suggesting that a beta anomeric configuration of GlcNAc in the substrate is preferred (PubMed:7721776). Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme (PubMed:1977660)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Correlation of FUT3 and FUT6 Gene Polymorphisms With Helicobacter pylori Infection., [RefSeq, PubMed]; FUT3 facilitates glucose metabolism of lung adenocarcinoma via activation of NF-kappaB pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Maternal and child FUT2 and FUT3 status demonstrate relationship with gut health, body composition and growth of children in Bangladesh. Publication Status: Online-Only, [RefSeq, PubMed]; Relationship between ABO Blood Group Alleles and Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen (FUT3) Genotype., [RefSeq, PubMed]; The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral infection. [provided by RefSeq, Aug 2020]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 2,
        "mined_n_glycosites": 2,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 515,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5U7U9;B5U7V0;Q32NE7;Q99448;Q99449",
        "ec_number_list": "2.4.1.-;2.4.1.65;2.4.1.152",
        "go_molecular_function": "GO:0008417 fucosyltransferase activity;GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity;GO:0046920 alpha-(1->3)-fucosyltransferase activity;GO:0017083 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0032580 Golgi cisterna membrane",
        "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0042127 regulation of cell population proliferation;GO:0006493 protein O-linked glycosylation;GO:0006672 ceramide metabolic process;GO:0030334 regulation of cell migration",
        "synthesized_glycan_count": 816,
        "hit_score": 6.3,
        "record_id": "P21217-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9HAV0-1",
        "uniprot_id": "GBB4_HUMAN",
        "mass": 37567.0,
        "length": 340,
        "protein_name": "Guanine nucleotide-binding protein subunit beta-4",
        "gene_name": "GNB4",
        "organism": "Human",
        "refseq_name": "guanine nucleotide-binding protein subunit beta-4",
        "refseq_ac": "NP_067642",
        "gene_names_uniprotkb": "GNB4",
        "gene_names_refseq": "CMTD1F; GNB4; HG2B",
        "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit beta-4; Transducin beta chain 4",
        "protein_names_refseq": "G protein beta-4 subunit; guanine nucleotide binding protein (G protein), beta polypeptide 4; guanine nucleotide-binding protein subunit beta-4; heterotrimeric guanine nucleotide-binding protein 2B; transducin beta chain 4",
        "tax_id": 9606,
        "disease": "Charcot-Marie-Tooth disease dominant intermediate F (Disease Ontology:DOID:0110206)",
        "pathway": " (hsa:59345);  (R-HSA-1296041);  (R-HSA-163359);  (R-HSA-202040);  (R-HSA-381676);  (R-HSA-392170);  (R-HSA-392451);  (R-HSA-392851);  (R-HSA-400042);  (R-HSA-4086398);  (R-HSA-416476);  (R-HSA-416482);  (R-HSA-418217);  (R-HSA-418555);  (R-HSA-418592);  (R-HSA-418594);  (R-HSA-418597);  (R-HSA-420092);  (R-HSA-428930);  (R-HSA-432040);  (R-HSA-456926);  (R-HSA-500657);  (R-HSA-6814122);  (R-HSA-8964315);  (R-HSA-8964616);  (R-HSA-9009391);  (R-HSA-9634597);  (R-HSA-9660821);  (R-HSA-9856530);  (R-HSA-997272)",
        "pathway_count": 30,
        "publication_count": 496,
        "publication_id_list": "10191087;10215864;10318832;10319328;10322410;10376603;10380924;10391246;10391247;10395542;10427092;10449730;10488343;10496952;10567430;10588714;10634944;10639123;10649434;10698200;10714768;10727532;10749889;10759852;10764742;10777564;10806474;10858654;10861009;10948191;10954748;11007482;11015615;11029009;11029403;11030334;11034202;11043579;11044445;11060443;11071853;11076974;11185956;11196645;11237011;11283606;11294240;11313909;11313914;11369763;11563835;11689445;11698416;11742120;11753430;11773440;11773442;11773443;11786497;11825873;11842130;11853546;11946536;11968001;11981029;12015605;12034449;12036966;12048194;12058044;12086864;12101119;12106601;12120503;12123608;12167717;12176338;12180353;12180908;12194985;12388769;12401793;12410638;12421825;12431978;12433842;12446735;12471263;12475787;12482967;12496249;12507995;12511868;12515866;12556497;12560222;12588983;12682286;12724311;12729560;12801959;12808053;12860470;12881510;12887923;12938160;12975316;1325798;1333056;1347957;13549488;13680124;1373524;1378832;14514350;14514735;14573771;14592814;14671004;14675202;14701836;14704854;14742685;14764897;14977528;14988243;15033483;15044318;15090535;1510932;1517224;15231873;15245432;15304325;15314172;1534149;15464082;15467163;15471943;15494017;15496458;15539556;15545263;15569269;15569929;15611108;15657067;15699075;15703994;15705661;15705806;15718470;15749160;15765929;15769620;15889144;15951850;15955806;15956360;15980156;15995848;16102047;16120822;16182515;16212421;16212495;16239258;16268778;16274718;16313925;16339447;16352729;16371464;16373322;16407073;16407156;16415903;16418336;1645720;16460020;16580177;16613879;16634148;16636149;16645038;16687412;16702223;16717095;1672265;16754659;16780920;16835357;16880514;16892066;16920709;16923326;16973695;17037979;17095603;17156409;17168849;17178220;17185339;17306374;17379646;1739432;17424910;17426020;17444618;17525128;17535799;17545310;17684012;17900700;17916740;17921256;18044684;18162464;18202100;18202181;18206197;1825698;18287102;18374420;18412318;18434541;18456304;18488142;1849000;18511455;1851174;18515384;18566127;18577758;18657504;18678926;18710921;18936096;19020623;1905813;19105585;19138696;19144687;19170255;19177143;19212140;19258039;19342380;19342448;19376773;19383790;1939224;19536106;19574955;19715408;19723632;19741198;19851316;19859570;19861722;19876791;19879889;19929708;19931550;20007474;20381629;20439495;20453851;20650261;20655490;20670195;20861220;21036126;21118996;21172430;2163110;21680538;21844907;21851428;21903638;22028449;22031296;22266855;22446104;22480736;22495674;22661716;22941947;23151663;23256519;23416699;23434117;23632248;23637185;23863937;23904219;24039841;2417744;24273487;24530924;24687066;2474350;2491850;24962572;2534964;25414122;2553411;2553705;25576301;25587652;25645385;25659125;25675501;26190834;26308095;26417854;26590425;26987903;27072905;27288742;27392633;2748346;27566546;27797339;2826231;2834384;2841328;28450397;28502923;28539435;28595943;2871555;28904123;29242379;29351928;29443750;29493099;29557506;29602314;29738483;2991279;30007591;3049610;30833945;30833991;3086311;3104109;31205027;3127824;31279028;31399091;3141418;31844290;31848261;31983287;32157095;32226383;32296767;32350084;32357974;32387766;32488085;32497535;32540603;32618402;32639031;32715661;32938616;32983136;33049737;33298915;33592498;33633747;33691108;33717175;33936100;33968037;34171305;34357683;34398348;34405274;34433824;34499618;34509645;35051231;35154160;35251023;35580925;35756485;36010968;37016382;38154055;38665916;3899557;40596516;4065330;6085243;6192430;6745415;7503232;7510718;7512962;7514139;7526388;7526779;7532011;7535000;7538665;7559455;7567982;7568118;7589426;7589461;7595566;7624799;7641683;7651538;7678419;7680413;7700244;7750475;7811244;7876172;7902709;7937899;8007951;8015379;8063828;8073283;8099279;8138058;8140421;8144028;8208289;8277227;8290554;8340388;8390245;8404634;8405712;8406495;8514797;8521505;8522976;8527267;8554519;8598224;8617235;8621513;8662784;8664309;8672451;8683474;8700127;8702633;8733591;8778232;8782602;8816443;8830891;8855281;8876252;8910365;8982657;8997178;9073455;9087410;9152406;9153422;9173876;9227644;9263355;9305846;9308960;9369468;9374639;9374640;9389482;9395517;9417641;9488697;9544801;9565625;9616126;9618465;9620797;9651336;9707174;9756892;9760042;9770463;9796816;9829975;9920805;9924018;9990065",
        "class_list": "",
        "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Helicobacter pylori-induced aberrant demethylation and expression of GNB4 promotes gastric carcinogenesis via the Hippo-YAP1 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. [provided by RefSeq, Jul 2008]., [RefSeq]; High G protein subunit beta 4 protein level is correlated to poor prognosis of urothelial carcinoma., [RefSeq, PubMed]; Plasma methylated GNB4 and Riplet as a novel dual-marker panel for the detection of hepatocellular carcinoma., [RefSeq, PubMed]; Prognostic and Immunological Value of GNB4 in Gastric Cancer by Analyzing TCGA Database. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KMH5;D3DNR8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0030159 signaling receptor complex adaptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0070062 extracellular exosome;GO:0005765 lysosomal membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0021762 substantia nigra development;GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 49.9,
        "record_id": "Q9HAV0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5VT40-1",
        "uniprot_id": "FA78B_HUMAN",
        "mass": 29835.0,
        "length": 261,
        "protein_name": "Protein FAM78B",
        "gene_name": "FAM78B",
        "organism": "Human",
        "refseq_name": "protein FAM78B isoform 1",
        "refseq_ac": "NP_001017961",
        "gene_names_uniprotkb": "FAM78B",
        "gene_names_refseq": "FAM78B",
        "protein_names_uniprotkb": "Protein FAM78B",
        "protein_names_refseq": "protein FAM78B isoform 1; protein FAM78B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:149297)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "11237011;19064610;19536175;31844290;37217939",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z693",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q5VT40-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P11168-1",
        "uniprot_id": "GTR2_HUMAN",
        "mass": 57490.0,
        "length": 524,
        "protein_name": "Solute carrier family 2, facilitated glucose transporter member 2",
        "gene_name": "SLC2A2",
        "organism": "Human",
        "refseq_name": "solute carrier family 2, facilitated glucose transporter member 2 isoform 1",
        "refseq_ac": "NP_000331",
        "gene_names_uniprotkb": "SLC2A2; GLUT2",
        "gene_names_refseq": "GLUT2; SLC2A2",
        "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 2; GLUT-2; Glucose transporter type 2, liver",
        "protein_names_refseq": "glucose transporter type 2, liver; solute carrier family 2 (facilitated glucose transporter), member 2; solute carrier family 2, facilitated glucose transporter member 2 isoform 1",
        "tax_id": 9606,
        "disease": "Fanconi-Bickel syndrome (Disease Ontology:DOID:0070562); glycogen storage disease (Disease Ontology:DOID:2747); insulinoma (Disease Ontology:DOID:3892); gastrinoma (Disease Ontology:DOID:5577); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:6514);  (R-HSA-189200);  (R-HSA-210745);  (R-HSA-422356);  (R-HSA-5619098);  (R-HSA-8981373)",
        "pathway_count": 6,
        "publication_count": 152,
        "publication_id_list": "10194514;10206966;10342826;10424882;10526167;10697967;10773014;10821868;10860667;10866047;10868950;10970791;10987651;11044475;11078440;11078469;11133510;11237011;11245466;11247674;11264248;11425315;11577798;11583593;11681785;11716850;11741323;11780755;11810292;11815450;11815460;11815462;11815463;11832379;11873862;11978637;11994746;12196472;12403834;12475777;12504846;12590146;12684222;12764427;12885248;12887316;1309948;13459201;13480676;1415574;14514350;14614622;14739288;14997204;15000528;15033637;15305887;15397919;1550217;15504896;15546855;15572341;15585596;15607332;15678092;15902306;16154905;16186102;16332676;1634504;16443778;16513675;16550171;16556766;16714477;16788146;16868246;1701966;17021801;17050778;17259518;17380317;1756912;17635959;17660294;17900700;17919183;18063724;18162464;18327257;18346985;18596924;1918382;19587354;20086079;20616166;21107422;21940664;22212718;22521588;23396969;23992284;24275569;24715725;26517901;2656669;26650681;28083649;28832583;29108130;29548810;29557506;30459171;31067468;3399500;34828390;35051231;3517644;36465606;37257183;37884694;3839598;3923453;40209957;6019353;6424440;6435940;7564233;7589840;7593414;7593639;7632512;7641683;7929812;8027028;8063045;8362811;8457197;8563765;8626492;8675920;8922363;8987985;8997178;9266402;9350615;9354798;9686354;9726229;9739505;9751501;9914469",
        "class_list": "glycogene",
        "function": "Association Between the SLC2A2 Gene rs1499821 Polymorphism and Caries Susceptibility., [RefSeq, PubMed]; Decreased expression of Glucagon-like peptide-1 receptor and Sodium-glucose co-transporter 2 in patients with proliferative diabetic retinopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Evidence for a Genotype-Phenotype Correlation in Patients with Pathogenic GLUT2 (SLC2A2) Variants. Publication Status: Online-Only, [RefSeq, PubMed]; Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8027028, PubMed:8457197). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of beta cells (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate and urate (PubMed:23396969, PubMed:40209957)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter., [RefSeq, PubMed]; The glucose transporter 2 regulates CD8[+] T cell function via environment sensing. Erratum:[Nat Metab. 2025 Mar;7(3):634. doi: 10.1038/s42255-025-01256-3. PMID: 40000839], [RefSeq, PubMed]; This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 647,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K481;B2R936;B7Z547;F8W8V8;Q9UCW9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0015149 hexose transmembrane transporter activity;GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0005353 fructose transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity;GO:0005354 galactose transmembrane transporter activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005911 cell-cell junction;GO:0016020 membrane",
        "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0005975 carbohydrate metabolic process;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0015755 fructose transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 15.5,
        "record_id": "P11168-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "H0YM25-1",
        "uniprot_id": "GG6LV_HUMAN",
        "mass": 107774.0,
        "length": 854,
        "protein_name": "Golgin subfamily A member 6-like protein 22",
        "gene_name": "GOLGA6L22",
        "organism": "Human",
        "refseq_name": "golgin subfamily A member 6-like protein 22 isoform 1",
        "refseq_ac": "NP_001383885",
        "gene_names_uniprotkb": "GOLGA6L22",
        "gene_names_refseq": "GOLGA6L22",
        "protein_names_uniprotkb": "Golgin subfamily A member 6-like protein 22",
        "protein_names_refseq": "golgin subfamily A member 6-like protein 22 isoform 1; golgin subfamily A member 6-like protein 22",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:440243)",
        "pathway_count": 1,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A087X0V3",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "H0YM25-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96LP2-1",
        "uniprot_id": "FA81B_HUMAN",
        "mass": 52022.0,
        "length": 452,
        "protein_name": "Protein FAM81B",
        "gene_name": "FAM81B",
        "organism": "Human",
        "refseq_name": "protein FAM81B",
        "refseq_ac": "NP_689761",
        "gene_names_uniprotkb": "FAM81B",
        "gene_names_refseq": "FAM81B",
        "protein_names_uniprotkb": "Protein FAM81B",
        "protein_names_refseq": "protein FAM81B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:153643)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "11237011;29557506;35580925",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q96LP2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N0W3-1",
        "uniprot_id": "FCSK_HUMAN",
        "mass": 117623.0,
        "length": 1084,
        "protein_name": "L-fucose kinase",
        "gene_name": "FCSK",
        "organism": "Human",
        "refseq_name": "L-fucose kinase",
        "refseq_ac": "NP_659496",
        "gene_names_uniprotkb": "FCSK; FUK",
        "gene_names_refseq": "1110046B12Rik; CDGF2; FCSK; FUK",
        "protein_names_uniprotkb": "L-fucose kinase; 2.7.1.52; Fucokinase",
        "protein_names_refseq": "L-fucose kinase; fucokinase",
        "tax_id": 9606,
        "disease": "congenital disorder of glycosylation with defective fucosylation 2 (MONDO:MONDO:0020777)",
        "pathway": " (hsa:197258);  (R-HSA-6787639)",
        "pathway_count": 2,
        "publication_count": 45,
        "publication_id_list": "11237011;11326280;12056818;12753898;16086588;23774504;23922970;24715725;25576301;25892735;27543614;27738779;27846572;28228285;28832583;28904123;29242379;29769354;29924834;30315122;30503518;31844290;32157095;32357974;32387766;32488085;32897882;32983136;33141586;33298915;33537174;33592498;33912179;34078123;34087483;34185709;35051231;35494241;35580925;36010968;36241641;38722107;8910301;9525924;9603974",
        "class_list": "glycogene",
        "function": "Ectopic expression of FUK inhibits the formation and the proteolytic activities of invadopodia, suggesting that the fucose salvage pathway might control melanoma invasion through invadopodium-mediated ECM remodeling. FUK depletion in WM793 melanoma cells at least partially abrogated the L-fucose-mediated inhibition of invadopodium formation. Publication Status: Online-Only, [RefSeq, PubMed]; Novel insight into FCSK-congenital disorder of glycosylation through a CRISPR-generated cell model., [RefSeq, PubMed]; Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1443,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5PSM3;Q5XKL6;Q6ZRA0;Q96MT9",
        "ec_number_list": "2.7.1.52",
        "go_molecular_function": "GO:0050201 fucokinase activity;GO:0005524 ATP binding;GO:0000166 nucleotide binding;GO:0016301 kinase activity",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0042352 GDP-L-fucose salvage;GO:0046835 carbohydrate phosphorylation;GO:0042350 GDP-L-fucose biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.6,
        "record_id": "Q8N0W3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P82094-1",
        "uniprot_id": "TMF1_HUMAN",
        "mass": 122842.0,
        "length": 1093,
        "protein_name": "TATA element modulatory factor",
        "gene_name": "TMF1",
        "organism": "Human",
        "refseq_name": "TATA element modulatory factor isoform 1",
        "refseq_ac": "NP_009045",
        "gene_names_uniprotkb": "TMF1; ARA160",
        "gene_names_refseq": "ARA160; TMF1; TMF",
        "protein_names_uniprotkb": "TATA element modulatory factor; Androgen receptor coactivator 160 kDa protein; Androgen receptor-associated protein of 160 kDa; TMF",
        "protein_names_refseq": "TATA element modulatory factor isoform 1; androgen receptor coactivator 160 kDa protein; androgen receptor-associated protein of 160 kDa",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7110);  (R-HSA-6811440)",
        "pathway_count": 2,
        "publication_count": 150,
        "publication_id_list": "10209123;10428808;10445031;10559959;10637310;10865125;10990452;11237011;11303027;11346801;11359012;11689439;11827983;11839770;12044884;12070132;12377769;12620188;12620189;1409643;14580338;14718928;15029241;15037235;15077113;15077114;15128430;15269279;15467733;15483056;15654769;15758030;15870108;15878329;16042553;16129887;16571679;16885419;16912714;16936697;16964243;17081983;17451557;17488291;17562788;17684057;17698061;18195106;18243103;18256213;18367545;18664496;18669648;18691976;18767875;18946081;19007248;19164740;19413330;19415658;19490898;19620288;19651622;19664994;19664995;19690332;20068231;20685960;21183348;21406692;21421921;21436057;21689688;21807881;22335553;22354037;22581368;22717455;23091056;23186163;23239882;23301498;23437303;23481700;24275569;24478191;24794632;25343031;25418920;25576301;25880248;26154972;26992070;27600516;27920218;28228285;28832583;28904123;29242379;29314611;29393594;29493099;29508533;29545370;29557506;29632711;29786170;30315122;30379171;30429286;30573663;30833945;31154438;31217245;31530632;31844290;31848261;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33592498;33912179;33968037;33981976;34171305;34509645;34561969;35051231;35154160;35318648;35580925;36215666;36241641;40307207;7909812;8221884;8440258;8620540;8636227;8670882;9050864;9177194;9230071;9590177",
        "class_list": "",
        "function": "COG complex interacts with two different Rabs in addition to each end of the golgin 'TATA element modulatory factor' (TMF)., [RefSeq, PubMed]; In patient with chronic granulomatous disease, a 5.8-kb, incomplete and partly exonized TMF1 transcript was identified in intron 1 of CYBB, in opposite orientation to the host gene., [RefSeq, PubMed]; In the nucleus, PDGFRbeta formed ligand-inducible complexes with the tyrosine kinase Fer and its substrate, TATA element-modifying factor 1 (TMF-1)., [RefSeq, PubMed]; Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 32,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZLJ2;Q17R87;Q59GK0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0050681 nuclear androgen receptor binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030521 androgen receptor signaling pathway;GO:0061136 regulation of proteasomal protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 15.3,
        "record_id": "P82094-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NYY8-1",
        "uniprot_id": "FAKD2_HUMAN",
        "mass": 81463.0,
        "length": 710,
        "protein_name": "FAST kinase domain-containing protein 2, mitochondrial",
        "gene_name": "FASTKD2",
        "organism": "Human",
        "refseq_name": "FAST kinase domain-containing protein 2, mitochondrial",
        "refseq_ac": "NP_001129665",
        "gene_names_uniprotkb": "FASTKD2; KIAA0971",
        "gene_names_refseq": "COXPD44; FASTKD2; KIAA0971",
        "protein_names_uniprotkb": "FAST kinase domain-containing protein 2, mitochondrial",
        "protein_names_refseq": "FAST kinase domain-containing protein 2, mitochondrial",
        "tax_id": 9606,
        "disease": "combined oxidative phosphorylation deficiency (Disease Ontology:DOID:0060286); combined oxidative phosphorylation deficiency 44 (Disease Ontology:DOID:0070424)",
        "pathway": " (hsa:22868);  (R-HSA-6793080);  (R-HSA-9837092);  (R-HSA-9937008)",
        "pathway_count": 4,
        "publication_count": 103,
        "publication_id_list": "10931946;11237011;11809803;12496758;15110318;15769737;18083837;18669648;18771761;19356719;19417006;20869947;20877624;21292163;21531335;22341444;22949673;23022348;23186163;23303773;23481700;23804760;24036117;24275569;24746820;25008111;25009282;25074936;25418920;25576301;25645385;25683715;26154972;26370583;26375851;26464487;26929215;26992070;27600516;27667664;27846572;27862975;27920218;27974379;28082677;28218747;28228285;28335001;28499982;28514659;28832583;28834231;28855257;28904123;29107537;29393594;29437277;29493099;29557506;29632046;29786170;30315122;30410026;30429286;30524438;30833945;31154438;31217245;31477916;31844290;31848261;31937595;31944455;32157095;32161166;32357974;32387766;32897882;32938616;32983136;33141586;33298915;33592498;33633747;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34405274;34509645;34748562;34932366;35051231;35729327;36010968;36215666;36241641;36284347",
        "class_list": "",
        "function": "A novel homozygous missense mutation in the FASTKD2 gene leads to Lennox-Gastaut syndrome., [RefSeq, PubMed]; Mutation in a gene segregating with a peculiar mitochondrial encephalomyopathy associated with COX deficiency in skeletal muscle. FASTKD2 is localized in the mitochondrial inner compartment., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Plays an important role in assembly of the mitochondrial large ribosomal subunit (PubMed:25683715). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:25683715, PubMed:26370583, PubMed:27667664). May play a role in mitochondrial apoptosis., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a protein that is localized in the mitochondrial inner compartment and that may play a role in mitochondrial apoptosis. Nonsense mutations have been reported to result in cytochrome c oxidase deficiency. [provided by RefSeq, Oct 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9NVX6;Q9Y2H7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0019843 rRNA binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:0035770 ribonucleoprotein granule",
        "go_biological_process": "GO:0000963 mitochondrial RNA processing;GO:0006396 RNA processing;GO:0006915 apoptotic process;GO:1902775 mitochondrial large ribosomal subunit assembly;GO:0032543 mitochondrial translation",
        "synthesized_glycan_count": 0,
        "hit_score": 10.4,
        "record_id": "Q9NYY8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P20718-1",
        "uniprot_id": "GRAH_HUMAN",
        "mass": 27315.0,
        "length": 246,
        "protein_name": "Granzyme H",
        "gene_name": "GZMH",
        "organism": "Human",
        "refseq_name": "granzyme H isoform 3 precursor",
        "refseq_ac": "NP_001257710",
        "gene_names_uniprotkb": "GZMH; CGL2; CTSGL2",
        "gene_names_refseq": "CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2; GZMH",
        "protein_names_uniprotkb": "Granzyme H; 3.4.21.-; CCP-X; CSP-C; CTSGL2; Cathepsin G-like 2; Cytotoxic T-lymphocyte proteinase; Cytotoxic serine protease C",
        "protein_names_refseq": "cathepsin G-like 2, protein h-CCPX; cytotoxic T-lymphocyte proteinase; cytotoxic T-lymphocyte-associated serine esterase 1; cytotoxin serine protease-C; granzyme H isoform 3 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2999);  (R-HSA-2022377);  (R-HSA-381426)",
        "pathway_count": 3,
        "publication_count": 124,
        "publication_id_list": "10026136;10077652;10218588;10512690;10536878;10614670;10681634;10810289;10898936;10899625;10912521;10924499;10951195;10969042;10990447;11158056;11237011;11250653;11264294;11316783;11502696;11522292;11606061;11739083;11751371;11788658;11815627;12045255;12241545;12379487;12466191;12540854;12810533;12904166;12927775;1370451;1383255;14747736;15126567;15283675;15308688;15469690;15485880;15525596;15642270;1668266;16790432;17047378;17138938;17249697;17312271;17704566;17985932;1848554;1851160;19039329;19800993;20380117;2049336;20889553;2193684;22156497;22193701;2266130;23269243;23446738;2402757;24141856;2443571;2476804;2479552;2558510;26091039;2708524;2846041;28832583;29242379;29557506;29632711;29741879;3017438;30379171;31844290;32157095;32350084;33737344;33912179;35051231;35580925;36006802;37074911;383475;40914422;4289389;4322712;4330891;4360430;6269175;6270633;6303766;6807977;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7683646;7689487;7980644;8781553;8817670;8894645;8964575;9169443;9497324;9570564;9709957;9733769;9786878;9922210",
        "class_list": "",
        "function": "An unusual RKR motif (Arg39-Lys40-Arg41), conserved only in GzmH, helps define the S3' and S4' binding regions, indicating the preference for acidic residues at the P3' and P4' sites., [RefSeq, PubMed]; Cleavage of La protein by granzyme H generates a COOH-terminal truncated form of La protein that loses nuclear localization and decreases hepatitis C virus-internal ribosome entry site-mediated translational activity., [RefSeq, PubMed]; Copy number loss in granzyme genes confers resistance to immune checkpoint inhibitor in nasopharyngeal carcinoma., [RefSeq, PubMed]; Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication., [UniProtKB, PubMed, PubMed]; Natural Killer Cells Disrupt Nerve Fibers by Granzyme H in Atheriosclerotic Cerebral Small Vessel Disease., [RefSeq, PubMed]; This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "G3V2C5;Q6XGZ0;Q6XGZ1",
        "ec_number_list": "3.4.21.20;3.4.21.-",
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0044194 cytolytic granule",
        "go_biological_process": "GO:0006508 proteolysis;GO:0006915 apoptotic process;GO:0031640 killing of cells of another organism;GO:0051604 protein maturation",
        "synthesized_glycan_count": 0,
        "hit_score": 13.5,
        "record_id": "P20718-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6PIW4-1",
        "uniprot_id": "FIGL1_HUMAN",
        "mass": 74077.0,
        "length": 674,
        "protein_name": "Fidgetin-like protein 1",
        "gene_name": "FIGNL1",
        "organism": "Human",
        "refseq_name": "fidgetin-like protein 1 isoform 1",
        "refseq_ac": "NP_001036227",
        "gene_names_uniprotkb": "FIGNL1",
        "gene_names_refseq": "FIGNL1",
        "protein_names_uniprotkb": "Fidgetin-like protein 1; 3.6.4.-",
        "protein_names_refseq": "fidgetin-like protein 1 isoform 1; fidgetin-like protein 1",
        "tax_id": 9606,
        "disease": "nicotine dependence (Disease Ontology:DOID:0050742)",
        "pathway": " (hsa:63979);  (R-HSA-5693568);  (R-HSA-912446)",
        "pathway_count": 3,
        "publication_count": 114,
        "publication_id_list": "10029069;10438626;10562567;10728666;10734115;10928988;11237011;11292842;12686547;12721304;14527420;15164066;15304223;15707573;16123081;16292313;16322221;17289582;17525332;17541404;17965729;17977839;17981954;18256600;18535008;19058789;19596236;19608861;20044539;20044541;20062530;20068231;20818382;20965415;22645308;23186163;23301498;23509288;23754376;24076221;24371268;24509834;24714562;24715725;24831703;25576301;25645385;25880248;25892735;26154972;26811146;26992070;27397612;27600516;27846572;27920218;28063628;28218747;28228285;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29557506;29608566;29632046;29632711;29769354;29786170;29789417;30315122;30410026;30429286;30926776;31844290;31848261;32157095;32161166;32265295;32357974;32387766;32488085;32983136;33298915;33592498;33633747;33691108;33912179;33968037;34171305;34932366;35051231;35580925;36010968;37256941;37347663;37515771;37556550;37740949;37929733;37938771;38286805;38597669;39636933;41166468;8929543;9008167;9311981;9450758;9781043;9826763",
        "class_list": "",
        "function": "ATPase that maintains genome stability by acting as a key regulator of DNA double-strand break (DSB) repair via homologous recombination (HR) (PubMed:23754376, PubMed:37256941, PubMed:37347663, PubMed:37515771, PubMed:37556550, PubMed:38286805, PubMed:38597669, PubMed:39636933, PubMed:41166468). Regulates HR by mediating disassembly of RAD51 filaments from DNA and chromatin, thereby preventing DNA damage-independent RAD51 loading and persistent DNA accumulation of RAD51 recombinases (PubMed:37256941, PubMed:37347663, PubMed:37515771, PubMed:37556550, PubMed:38286805, PubMed:38597669, PubMed:39636933, PubMed:41166468). Also regulates HR during meiosis by mediating dissociation of DMC1 filaments from DNA (By similarity). May regulate osteoblast proliferation and differentiation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; FIGNL1 Promotes Hepatocellular Carcinoma Formation via Remodeling ECM-receptor Interaction Pathway Mediated by HMMR., [RefSeq, PubMed]; FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress. Publication Status: Online-Only, [RefSeq, PubMed]; Human AAA+ ATPase FIGNL1 suppresses RAD51-mediated ultra-fine bridge formation., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; RAD51-binding protein fidgetin-like 1 (FIGNL1) is identified; FIGNL1 specifically interacts with RAD51 through its conserved RAD51 binding domain. Cells depleted of FIGNL1 show defective homologous recombination repair., [RefSeq, PubMed]; This gene encodes a member of the AAA ATPase family of proteins. The encoded protein is recruited to sites of DNA damage where it plays a role in DNA double-strand break repair via homologous recombination. This protein has also been shown to localize to the centrosome and inhibit ciliogenesis, and may regulate the proliferation and differentiation of osteoblasts. [provided by RefSeq, Oct 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DVM6;Q86V18;Q8ND59;Q9H8P1;Q9H917",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;2.3.2.27;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.7.11.1;5.6.2.1;7.2.2.-;5.6.2.-;2.3.2.-;3.6.1.15;3.1.4.-;3.6.-.-;2.3.1.48;2.3.1.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0016887 ATP hydrolysis activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0033687 osteoblast proliferation;GO:0051013 microtubule severing;GO:0043066 negative regulation of apoptotic process;GO:0001649 osteoblast differentiation;GO:0007140 male meiotic nuclear division",
        "synthesized_glycan_count": 0,
        "hit_score": 11.7,
        "record_id": "Q6PIW4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6PJ61-1",
        "uniprot_id": "FBX46_HUMAN",
        "mass": 64631.0,
        "length": 603,
        "protein_name": "F-box only protein 46",
        "gene_name": "FBXO46",
        "organism": "Human",
        "refseq_name": "F-box only protein 46",
        "refseq_ac": "NP_001073938",
        "gene_names_uniprotkb": "FBXO46; FBX46; FBXO34L",
        "gene_names_refseq": "20D7-FC4; FBXO34L; FBXO46; Fbx46",
        "protein_names_uniprotkb": "F-box only protein 46; F-box only protein 34-like",
        "protein_names_refseq": "F-box only protein 46",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23403)",
        "pathway_count": 1,
        "publication_count": 47,
        "publication_id_list": "11237011;17081983;17322306;18669648;20068231;22544926;23186163;23481700;24714562;25645385;26375851;26728094;26992070;27846572;27920218;28514659;28649982;28832583;28834231;28904123;29242379;29393594;29493099;29557506;29632046;30171069;30779550;31530632;31844290;32265295;32387766;32502341;32938616;32983136;33633747;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34932366;35051231;35561310;35580925;36241641",
        "class_list": "",
        "function": "Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]., [RefSeq]; Reveal that FBXO46 is a crucial proteasomal regulator of FBXO31 and thereby prevents senescence in normal growth conditions, [RefSeq, PubMed]; Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31 (PubMed:30171069)., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex",
        "go_biological_process": "GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q6PJ61-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P17643-1",
        "uniprot_id": "TYRP1_HUMAN",
        "mass": 60724.0,
        "length": 537,
        "protein_name": "5,6-dihydroxyindole-2-carboxylic acid oxidase",
        "gene_name": "TYRP1",
        "organism": "Human",
        "refseq_name": "5,6-dihydroxyindole-2-carboxylic acid oxidase precursor",
        "refseq_ac": "NP_000541",
        "gene_names_uniprotkb": "TYRP1; CAS2; TYRP; TYRRP",
        "gene_names_refseq": "CAS2; CATB; GP75; OCA3; TRP1; TRP; TYRP1; TYRP; b-PROTEIN",
        "protein_names_uniprotkb": "5,6-dihydroxyindole-2-carboxylic acid oxidase; 1.14.18.-; Catalase B; DHICA oxidase; Glycoprotein 75; Melanoma antigen gp75; TRP-1; TRP1; TRP; Tyrosinase-related protein 1",
        "protein_names_refseq": "5,6-dihydroxyindole-2-carboxylic acid oxidase precursor; 5,6-dihydroxyindole-2-carboxylic acid oxidase; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75",
        "tax_id": 9606,
        "disease": "oculocutaneous albinism (Disease Ontology:DOID:0050632); oculocutaneous albinism type III (Disease Ontology:DOID:0070097); pigmentation disease (Disease Ontology:DOID:10123); obsolete skin/hair/eye pigmentation, variation in, 11 (MONDO:MONDO:0044276)",
        "pathway": " (hsa:7306);  (R-HSA-5662702);  (R-HSA-9824585)",
        "pathway_count": 3,
        "publication_count": 66,
        "publication_id_list": "10587587;11171088;11237011;11481264;11532965;11856727;11964381;12028586;12062444;12643545;1321344;1537333;1537334;15543135;15695812;15729346;1575733;15980237;16303920;16704458;1693779;17081065;17083485;17182843;17952075;18483556;18697795;18812475;1906272;19297406;19389701;1945866;19717472;2111010;21677667;22556244;2324688;23504663;24267888;25093188;25645385;26694611;27869121;28661582;30429286;30515787;31844290;32157095;32488085;33100333;33314655;33392160;33811629;34107850;34638544;35580127;4853153;6766744;7813420;8048919;8306979;8530077;8921401;9434945;9758418;9770375",
        "class_list": "",
        "function": "Association of TYRP1 with hypoxia and its correlation with patient outcome in uveal melanoma., [RefSeq, PubMed]; Evaluation of the effect of narrow band-ultraviolet B on the expression of tyrosinase, TYRP-1, and TYRP-2 mRNA in vitiligo skin and their correlations with clinical improvement: A retrospective study., [RefSeq, PubMed]; Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies., [RefSeq, PubMed]; Plays a role in melanin biosynthesis (PubMed:16704458, PubMed:22556244, PubMed:23504663). Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+) (PubMed:28661582). May regulate or influence the type of melanin synthesized (PubMed:16704458, PubMed:22556244). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]., [RefSeq]; Tyrp1 Mutant Variants Associated with OCA3: Computational Characterization of Protein Stability and Ligand Binding. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 7,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 7,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 7,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 6,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 37,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 4,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P78468;P78469;Q13721;Q15679",
        "ec_number_list": "1.14.18.1;1.14.18.-;3.6.4.-",
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0004503 tyrosinase activity;GO:0004097 catechol oxidase activity;GO:0004497 monooxygenase activity",
        "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0005737 cytoplasm;GO:0030669 clathrin-coated endocytic vesicle membrane;GO:0042470 melanosome;GO:0010008 endosome membrane",
        "go_biological_process": "GO:0032438 melanosome organization;GO:0042438 melanin biosynthetic process;GO:0048023 positive regulation of melanin biosynthetic process;GO:0030318 melanocyte differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 8.0,
        "record_id": "P17643-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96PS1-1",
        "uniprot_id": "FACOS_HUMAN",
        "mass": 20188.0,
        "length": 177,
        "protein_name": "FANCD2 opposite strand protein",
        "gene_name": "FANCD2OS",
        "organism": "Human",
        "refseq_name": "FANCD2 opposite strand protein",
        "refseq_ac": "NP_001158311",
        "gene_names_uniprotkb": "FANCD2OS; C3orf24; HSD19",
        "gene_names_refseq": "C3orf24; FANCD2OS",
        "protein_names_uniprotkb": "FANCD2 opposite strand protein; Fanconi anemia group D2 protein opposite strand transcript protein",
        "protein_names_refseq": "FANCD2 opposite strand protein; Fanconi anemia group D2 protein opposite strand transcript protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:115795)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "11237011;35051231",
        "class_list": "",
        "function": "Reduces testosterone levels by inhibiting steroidogenic enzymes and by promoting apoptosis in Leydig cells., [UniProtKB, UniProtKB]; This gene encodes a conserved protein of unknown function. [provided by RefSeq, Jan 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:2000225 negative regulation of testosterone biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q96PS1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q75N90-1",
        "uniprot_id": "FBN3_HUMAN",
        "mass": 300356.0,
        "length": 2809,
        "protein_name": "Fibrillin-3",
        "gene_name": "FBN3",
        "organism": "Human",
        "refseq_name": "fibrillin-3 precursor",
        "refseq_ac": "NP_001308360",
        "gene_names_uniprotkb": "FBN3; KIAA1776",
        "gene_names_refseq": "FBN3",
        "protein_names_uniprotkb": "Fibrillin-3",
        "protein_names_refseq": "fibrillin-3 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84467);  (R-HSA-1474228);  (R-HSA-1566948);  (R-HSA-2129379)",
        "pathway_count": 4,
        "publication_count": 94,
        "publication_id_list": "10.1101/2023.09.13.557529;10025398;10198291;10229672;10386589;10424889;10544250;10646116;10706100;10809722;10930463;10936461;10986281;11237011;11375993;11481325;11872628;11970960;12358597;12415008;12429738;12727852;12843408;1400330;14701737;14962672;14973287;15221638;15234972;15591058;15958533;16133547;1649600;16631740;16825321;16906757;1698775;1707285;1708799;17324935;17332331;17354228;17608959;17785364;18339631;18434311;18658137;19010778;19571574;19657146;19714641;20142769;20220067;21030783;21297635;21441952;21646718;21670566;21784848;21864727;22159414;22301903;23035980;23265956;23481700;23845380;24715725;27600516;29557506;29741879;29786170;30429286;31154438;31222486;32488085;33592498;34411563;35051231;35141985;39064490;6123066;7075587;7500359;7534784;7547873;8226919;8617364;8626565;9065415;9115292;9148753;9461298;9725916;9852107",
        "class_list": "",
        "function": "An association study showed a potential association of the D19S884 marker with PCOS in Chinese Han women and the meta-analysis identified that the A8 allele may increase susceptibility to PCOS, [RefSeq, PubMed]; Fibrillin-3 gene showed the strongest evidence for association with Polycystic ovary syndrome GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-containing microfibrils provide long-term force bearing structural support., [UniProtKB, PubMed]; Further delineation of familial polycystic ovary syndrome (PCOS) via whole-exome sequencing: PCOS-related rare FBN3 and FN1 gene variants are identified., [RefSeq, PubMed]; Genetic Insights into Skeletal Malocclusion: The Role of the FBN3 rs7351083 SNP in the Romanian Population. Publication Status: Online-Only, [RefSeq, PubMed]; The FBN3 risk allele may be associated with changes in basal glucose homeostasis in PCOS., [RefSeq, PubMed]; This gene encodes a memebr of the fibrillin protein family. Fibrillins are extracellular matrix molecules that assemble into microfibrils in many connective tissues. This gene is most highly expressed in fetal tissues and its protein product is localized to extracellular microfibrils of developing skeletal elements, skin, lung, kidney, and skeletal muscle. This gene is potentially involved in Weill-Marchesani syndrome. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 9,
        "predicted_n_glycosites": 8,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 16,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 16,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 16,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 149,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 15,
        "disease_count": 0,
        "glyco_site_count": 27,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q75N91;Q75N92;Q75N93;Q86SJ5;Q96JP8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005179 hormone activity;GO:0005201 extracellular matrix structural constituent;GO:0030023 extracellular matrix constituent conferring elasticity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0001527 microfibril",
        "go_biological_process": "GO:0042593 glucose homeostasis;GO:0006006 glucose metabolic process;GO:0048048 embryonic eye morphogenesis;GO:0043010 camera-type eye development",
        "synthesized_glycan_count": 0,
        "hit_score": 12.8,
        "record_id": "Q75N90-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q2V2M9-1",
        "uniprot_id": "FHOD3_HUMAN",
        "mass": 158613.0,
        "length": 1422,
        "protein_name": "FH1/FH2 domain-containing protein 3",
        "gene_name": "FHOD3",
        "organism": "Human",
        "refseq_name": "FH1/FH2 domain-containing protein 3 isoform 2",
        "refseq_ac": "NP_001268668",
        "gene_names_uniprotkb": "FHOD3; FHOS2; KIAA1695",
        "gene_names_refseq": "CMH28; FHOD3; FHOS2; Formactin2",
        "protein_names_uniprotkb": "FH1/FH2 domain-containing protein 3; Formactin-2; Formin homolog overexpressed in spleen 2; hFHOS2",
        "protein_names_refseq": "FH1/FH2 domain-containing protein 3 isoform 2; FH1/FH2 domain-containing protein 3; formactin-2; formin homolog overexpressed in spleen 2",
        "tax_id": 9606,
        "disease": "familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); cardiomyopathy, familial hypertrophic, 28 (MONDO:MONDO:0030317)",
        "pathway": " (hsa:80206)",
        "pathway_count": 1,
        "publication_count": 40,
        "publication_id_list": "11237011;15966898;19066393;19706596;21149568;23052206;23481700;24088304;25576301;25892735;28228285;28855257;29508533;29557506;29769354;30315122;30379171;30442288;31092671;31154438;31530632;31742804;31844290;32157095;32161166;32938616;33141586;33392160;33586461;33633747;33968037;34561969;35051231;35580925;36010968;38051749;38160043;38838015;39302247;39894887",
        "class_list": "",
        "function": "A novel splice-site FHOD3 founder variant is a common cause of hypertrophic cardiomyopathy in the population of the Balkans-A cohort study. Publication Status: Online-Only, [RefSeq, PubMed]; Actin dynamics regulated by Fhod3 are critical for sarcomere organization in striated muscle cells., [RefSeq, PubMed]; Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes., [UniProtKB, PubMed]; C-terminal phosphorylation by ROCK1 is sufficient for FHOD3 activation as evidenced by an increase in F-actin in HeLa cells., [RefSeq, PubMed]; DCM-associated FHOD3 variant may cause DCM by interfering with actin filament assembly., [RefSeq, PubMed]; Intermediate-effect size p.Arg637Gln in FHOD3 increases risk of HCM and is associated with an aggressive phenotype in homozygous carriers. Publication Status: Online-Only, [RefSeq, PubMed]; Single nucleotide polymorphism in FHOD3 gene is associated with acute lymphoblastic leukemia., [RefSeq, PubMed]; The protein encoded by this gene is a member of the diaphanous-related formins (DRF), and contains multiple domains, including GBD (GTPase-binding domain), DID (diaphanous inhibitory domain), FH1 (formin homology 1), FH2 (formin homology 2), and DAD (diaphanous auto-regulatory domain) domains. This protein is thought to play a role in actin filament polymerization in cardiomyocytes. Mutations in this gene have been associated with dilated cardiomyopathy (DCM), characterized by dilation of the ventricular chamber, leading to impairment of systolic pump function and subsequent heart failure. Increased levels of the protein encoded by this gene have been observed in individuals with hypertrophic cardiomyopathy (HCM). Alternative splicing results in multiple transcript variants encoding different isoforms. A muscle-specific isoform has been shown to possess a casein kinase 2 (CK2) phosphorylation site at the C-terminal end of the FH2 domain. Phosphorylation of this site alters its interaction with sequestosome 1 (SQSTM1), and targets this isoform to myofibrils, while other isoforms form cytoplasmic aggregates. [provided by RefSeq, Aug 2015]., [RefSeq]; Variant Spectrum of Formin Homology 2 Domain-Containing 3 Gene in Chinese Patients With Hypertrophic Cardiomyopathy., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 50,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MQT4;E5F5Q0;Q642I2;Q6ZRQ7;Q86TF9;Q8N3A5;Q9C0G8;Q9H604;Q9H6G7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0030018 Z disc",
        "go_biological_process": "GO:0007015 actin filament organization;GO:0051496 positive regulation of stress fiber assembly;GO:0055003 cardiac myofibril assembly;GO:0045214 sarcomere organization",
        "synthesized_glycan_count": 0,
        "hit_score": 4.4,
        "record_id": "Q2V2M9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q4G0N7-1",
        "uniprot_id": "F229B_HUMAN",
        "mass": 8717.0,
        "length": 80,
        "protein_name": "Protein FAM229B",
        "gene_name": "FAM229B",
        "organism": "Human",
        "refseq_name": "protein FAM229B",
        "refseq_ac": "NP_001028736",
        "gene_names_uniprotkb": "FAM229B; C6orf225",
        "gene_names_refseq": "C6orf225; FAM229B",
        "protein_names_uniprotkb": "Protein FAM229B",
        "protein_names_refseq": "UPF0731 protein C6orf225; protein FAM229B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:619208)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "24366607;25576301;27869121;27920218;30429286;31844290;31848261;32157095;32357974;32897882;33592498;33912179;33981976;36241641",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B8ZZ33",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q4G0N7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5T1H1-3",
        "uniprot_id": "EYS_HUMAN",
        "mass": 350796.0,
        "length": 3165,
        "protein_name": "Protein eyes shut homolog",
        "gene_name": "EYS",
        "organism": "Human",
        "refseq_name": "protein eyes shut homolog isoform 1 precursor",
        "refseq_ac": "NP_001136272",
        "gene_names_uniprotkb": "EYS; C6orf178; C6orf179; C6orf180; EGFL10; EGFL11; PRO34591; SPAM",
        "gene_names_refseq": "C6orf178; C6orf179; C6orf180; EGFL10; EGFL11; EYS; RP25; SPAM; bA166P24.2; bA307F22.3; bA74E24.1; dJ1018A4.2; dJ22I17.2; dJ303F19.1",
        "protein_names_uniprotkb": "Protein eyes shut homolog; EGF-like protein 10; EGF-like protein 11; Epidermal growth factor-like protein 10; Epidermal growth factor-like protein 11; Protein spacemaker homolog",
        "protein_names_refseq": "EGF-like-domain, multiple 10; EGF-like-domain, multiple 11; epidermal growth factor-like protein 10; epidermal growth factor-like protein 11; eyes shut homolog; protein eyes shut homolog isoform 1 precursor; protein spacemaker homolog",
        "tax_id": 9606,
        "disease": "cone-rod dystrophy (Disease Ontology:DOID:0050572); retinitis pigmentosa 25 (Disease Ontology:DOID:0110384); retinitis pigmentosa (Disease Ontology:DOID:10584); retinal degeneration (Disease Ontology:DOID:8466)",
        "pathway": " (hsa:346007)",
        "pathway_count": 1,
        "publication_count": 29,
        "publication_id_list": "12975309;18510646;18510647;18836446;18976725;20333770;20696082;21069908;26593283;26758079;27737822;27846257;29557506;30484775;30779550;31154438;32387766;32938616;33141586;34019948;34509645;35051231;35580925;36010968;36513702;37217939;37418643;38253038;38646933",
        "class_list": "",
        "function": "EYS is identified as a human ortholog of Drosopbhila eys, which is mutated in patients with retinitis pigmentosa., [RefSeq, PubMed]; Genotypic and phenotypic profiles of EYS gene-related retinitis pigmentosa: a retrospective study. Publication Status: Online-Only, [RefSeq, PubMed]; In order to validate the original linkage of RP25, study undertook a total genome scan using the 10K GeneChip mapping array on 3 of the previously linked families; data obtained supported the initial findings of linkage., [RefSeq, PubMed]; Phototoxicity avoidance is a potential therapeutic approach for retinal dystrophy caused by EYS dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]; RETINITIS PIGMENTOSA ASSOCIATED WITH THE EYS C2139Y VARIANT : An Important Cause of Blindness in East Asian Populations., [RefSeq, PubMed]; Required to maintain the integrity of photoreceptor cells (PubMed:18836446). Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone (By similarity)., [UniProtKB, PubMed, UniProtKB]; The product of this gene contains multiple epidermal growth factor (EGF)-like and LamG domains. The protein is expressed in the photoreceptor layer of the retina, and the gene is mutated in autosomal recessive retinitis pigmentosa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]., [RefSeq]; To study if copy number variation exists within RP25, comparative genomic hybridization analysis on a consanguineous family revealed a clone, chr6tp-19C7, spanning 100-Kb was deleted in all affected members of the family. Erratum:[Ann Hum Genet. 2015 Jan;79(1):83], [RefSeq, PubMed]",
        "predicted_glycosites": 9,
        "predicted_n_glycosites": 8,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 73,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RUR2;A8MVE7;B7TYK8;B7UUQ3;B7ZBE7;B7ZBE8;B7ZBR3;B9ZVD2;Q5SZM4;Q5T3C8;Q5T669;Q5TEL3;Q5TEL4;Q5VVG4;Q6UY05;Q9H557;Q9NQ15",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005201 extracellular matrix structural constituent",
        "go_cellular_component": "GO:0033165 interphotoreceptor matrix;GO:0005615 extracellular space;GO:0005813 centrosome;GO:0070062 extracellular exosome;GO:0005814 centriole",
        "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0050908 detection of light stimulus involved in visual perception",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q5T1H1-3",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5TYM5-1",
        "uniprot_id": "FA72A_HUMAN",
        "mass": 16619.0,
        "length": 149,
        "protein_name": "Protein FAM72A",
        "gene_name": "FAM72A",
        "organism": "Human",
        "refseq_name": "protein FAM72A isoform 1",
        "refseq_ac": "NP_001116640",
        "gene_names_uniprotkb": "FAM72A; UGENE",
        "gene_names_refseq": "FAM72A; LMPIP; Ugene; p17",
        "protein_names_uniprotkb": "Protein FAM72A; LMP1-induced protein; LMPIP; Latent membrane protein 1-induced protein",
        "protein_names_refseq": "LMP1-induced protein; Protein FAM72A; latent membrane protein 1-induced protein; protein FAM72A isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:729533)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "11237011;18676834;19755123;21317926;23900679;26154972;31844290;32938616;33392160;33936100;33968037;33981976;34087483;34171305;34211107;34819670;36215666;36613817;36757015;36868233",
        "class_list": "",
        "function": "Data indicate that p17 (p17 amyloid-beta peptide-induced protein; known as Ugene, LMPIP, or FAM72A/B) drives the cell cycle into the G0/G1 phase and enhances survival of proliferating cells., [RefSeq, PubMed]; FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation., [RefSeq, PubMed]; Fam72a functions as a cell-cycle-controlled gene during proliferation and antagonizes apoptosis through reprogramming PP2A substrates., [RefSeq, PubMed]; It was found that Ugene, designated herein as LMP1-induced protein (LMPIP), was induced, in a time-dependent manner, in EBV-infected peripheral blood mononuclear cells and LMP1-transfected 293 cells., [RefSeq, PubMed]; May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation., [UniProtKB, PubMed]; Prognostic and Immunological Implications of FAM72A in Pan-Cancer and Functional Validations. Publication Status: Online-Only, [RefSeq, PubMed]; The pan-cancer analysis of the oncogenic role of FAM72A as a BRCA prognostic biomarker and immunotherapeutic target., [RefSeq, PubMed]; This study provides an additional possible mechanism of neurotoxicity in Alzheimer's disease, the induction of p17(FAM72B), through which Abeta acts to induce apoptosis and exhibit other Alzheimer's disease characteristics., [RefSeq, PubMed]; Using deletion constructs, the authors find that Ugene binds to the first 25 amino acids of the UNG2 NH(2) terminus. They suggest that Ugene induction in cancer may contribute to the cancer phenotype by interacting with the BER pathway., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RV15;Q5TYM4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q5TYM5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6GMR7-1",
        "uniprot_id": "FAAH2_HUMAN",
        "mass": 58304.0,
        "length": 532,
        "protein_name": "Fatty-acid amide hydrolase 2",
        "gene_name": "FAAH2",
        "organism": "Human",
        "refseq_name": "fatty-acid amide hydrolase 2 isoform 1",
        "refseq_ac": "NP_777572",
        "gene_names_uniprotkb": "FAAH2; AMDD",
        "gene_names_refseq": "AMDD; FAAH2",
        "protein_names_uniprotkb": "Fatty-acid amide hydrolase 2; 3.5.1.99; Amidase domain-containing protein; Anandamide amidohydrolase 2; Oleamide hydrolase 2",
        "protein_names_refseq": "amidase domain containing; amidase domain-containing protein; anandamide amidohydrolase 2; fatty-acid amide hydrolase 2 isoform 1; oleamide hydrolase 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:158584);  (R-HSA-2142753)",
        "pathway_count": 2,
        "publication_count": 20,
        "publication_id_list": "15671038;15897321;17015445;19095868;19926788;21247147;21746768;23481700;25885783;27920218;28832583;29242379;33141586;33298915;34087483;35051231;35580925;36010968;6810878;7954810",
        "class_list": "",
        "function": "A male patient with neuropsychiatric disorders attributed to a FAAH2 missense mutation is described. Publication Status: Online-Only, [RefSeq, PubMed]; Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase., [RefSeq, PubMed]; Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:17015445, PubMed:19926788). Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates., [UniProtKB, PubMed, PubMed]; FAAH2 is the second membrane-associated AS enzyme in humans that displays FAAH activity, [RefSeq, PubMed]; Results establish FAAH-2 as a bone fide N-acylethanolamine-catabolizing enzyme and suggest that inactivation is spatially separated in cells of higher mammals, [RefSeq, PubMed]; This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86VT2;Q96N98",
        "ec_number_list": "3.5.1.99;3.1.1.-;3.5.1.23;3.5.1.60",
        "go_molecular_function": "GO:0017064 fatty acid amide hydrolase activity",
        "go_cellular_component": "GO:0005811 lipid droplet;GO:0016020 membrane",
        "go_biological_process": "GO:0016042 lipid catabolic process;GO:0019369 arachidonate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q6GMR7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6NZ36-1",
        "uniprot_id": "FAP20_HUMAN",
        "mass": 19869.0,
        "length": 180,
        "protein_name": "Fanconi anemia core complex-associated protein 20",
        "gene_name": "FAAP20",
        "organism": "Human",
        "refseq_name": "Fanconi anemia core complex-associated protein 20 isoform 6",
        "refseq_ac": "NP_001269599",
        "gene_names_uniprotkb": "FAAP20; C1orf86; FP7162",
        "gene_names_refseq": "C1orf86; FAAP20; FP7162",
        "protein_names_uniprotkb": "Fanconi anemia core complex-associated protein 20; FANCA-associated protein of 20 kDa; Fanconi anemia-associated protein of 20 kDa",
        "protein_names_refseq": "FANCA-associated protein of 20 kDa; Fanconi anemia core complex associated protein 20; Fanconi anemia core complex-associated protein 20 isoform 6; Fanconi anemia-associated protein of 20 kDa",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:199990);  (R-HSA-6783310);  (R-HSA-9833482)",
        "pathway_count": 3,
        "publication_count": 215,
        "publication_id_list": "10082513;10348343;10400669;10620360;10626894;10648614;10848580;10866685;11096080;11134010;11152499;11156368;11237011;11238103;11238927;11239454;11278865;11313968;11337501;11350938;11438540;11500375;11781817;11909525;11939789;11985496;12231563;12397061;12882984;1373135;14585331;15229216;15299030;15498874;15572677;15737233;15752359;15907845;16179258;16179259;16373505;16431927;16600570;16717090;16916645;16943440;1695551;16982605;17079286;17196820;17289582;17412408;17460694;17938197;18082604;18096616;18174376;18835251;18931676;18957415;19111657;19229320;19416861;19561358;19589784;19596236;19710021;19733181;19804757;19838063;19995904;20102227;20347428;20347429;20385554;20395957;20519500;20603015;20603016;20603073;20670894;20671156;20685959;21072047;21123651;21294215;21464321;21518807;21636578;21701511;21764741;21937648;21978664;21994559;22214662;22258451;22266823;22287633;22343915;22396592;2247437;22510687;22692201;22705371;22986343;23084476;23186163;23229543;23325218;23698467;23723247;23732991;24076221;24347309;24389026;24623135;24623813;24659800;24715725;24726325;24753571;24905007;25430771;25500724;25653431;25848059;26432638;26446704;26488609;26716879;26817845;27208315;27232758;27269119;27423063;27920218;27974558;28069888;28167698;28218747;28228285;28281686;28765891;28832583;29170442;29175459;29231267;29242379;29348664;29394925;29395325;29437277;29440070;29501855;29557506;29632711;29786170;30174290;30410026;30770398;30789902;31031002;31222486;31844290;32093270;32157095;32357974;32387766;32488085;32502341;32716602;32763975;32801355;32897882;32938616;33537174;33808629;33911136;33912179;33968037;34171305;34174402;34509645;34932366;34974812;35051231;35580925;35685460;35947956;36010968;36284347;36712380;37127961;37620397;7491766;7515177;7545299;7565688;7693978;7737357;7903669;8576172;8576179;8661426;8810342;8910500;9034343;9079663;9442054;9521856;9528799;9687506;9737981;9819388;9920933",
        "class_list": "",
        "function": "Acetylation modulates the Fanconi anemia pathway by protecting FAAP20 from ubiquitin-mediated proteasomal degradation., [RefSeq, PubMed]; Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; FAAP20 contains a conserved ubiquitin-binding zinc-finger domain and binds K-63-linked ubiquitin chains in vitro. The FAAP20-UBZ domain is not required for interaction with FANCA, but is required for DNA-damage-induced chromatin loading of FANCA and the functional integrity of the Fanconi anemia pathway., [RefSeq, PubMed]; FAAP20 is an important player involved in the Fanconi anemia pathway, [RefSeq, PubMed]; Fanconi anemia associated protein 20 (FAAP20) plays an essential role in homology-directed repair of DNA double-strand breaks. Publication Status: Online-Only, [RefSeq, PubMed]; Study identify SCF-FBW7 as a ubiquitin E3 ligase that regulates the cellular FAAP20 levels and Fanconi anemia (FA) pathway. Deregulation of the GSK3beta- and FBW7-dependent FAAP20 degradation leads to a defect in the FA pathway, establishing a direct link between FBW7 and DNA repair., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6PW39;A6PW40;A6PW41;A8MQT6;F2Z2L4;Q6ZT64;Q71M24;Q96ND7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0008270 zinc ion binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0043130 ubiquitin binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding",
        "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0000785 chromatin",
        "go_biological_process": "GO:0006974 DNA damage response;GO:0036297 interstrand cross-link repair;GO:0019985 translesion synthesis",
        "synthesized_glycan_count": 0,
        "hit_score": 21.6,
        "record_id": "Q6NZ36-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6P2I3-1",
        "uniprot_id": "FAH2B_HUMAN",
        "mass": 34613.0,
        "length": 314,
        "protein_name": "Oxaloacetate tautomerase FAHD2B, mitochondrial",
        "gene_name": "FAHD2B",
        "organism": "Human",
        "refseq_name": "oxaloacetate tautomerase FAHD2B, mitochondrial isoform a",
        "refseq_ac": "NP_001307777",
        "gene_names_uniprotkb": "FAHD2B",
        "gene_names_refseq": "FAHD2B",
        "protein_names_uniprotkb": "Oxaloacetate tautomerase FAHD2B, mitochondrial; 5.3.2.2; Fumarylacetoacetate hydrolase domain-containing protein 2B",
        "protein_names_refseq": "fumarylacetoacetate hydrolase domain-containing protein 2B; oxaloacetate tautomerase FAHD2B, mitochondrial isoform a; oxaloacetate tautomerase FAHD2B, mitochondrial",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:151313)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "11237011;23481700;24715725;26154972;26375851;27846572;27920218;28063628;28228285;28649982;28904123;29242379;29493099;29632046;31844290;32357974;32387766;32502341;33141586;38287013",
        "class_list": "",
        "function": "Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate (PubMed:38287013). It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition (PubMed:38287013)., [UniProtKB, PubMed, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DXH7;Q8NDK1",
        "ec_number_list": "5.3.2.2;3.7.1.5;4.1.1.112",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0050163 oxaloacetate tautomerase activity",
        "go_cellular_component": "GO:0005739 mitochondrion",
        "go_biological_process": "GO:0006107 oxaloacetate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q6P2I3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6P587-4",
        "uniprot_id": "FAHD1_HUMAN",
        "mass": 24542.0,
        "length": 221,
        "protein_name": "Oxaloacetate tautomerase FAHD1, mitochondrial",
        "gene_name": "FAHD1",
        "organism": "Human",
        "refseq_name": "oxaloacetate tautomerase FAHD1, mitochondrial isoform 1",
        "refseq_ac": "NP_001018114",
        "gene_names_uniprotkb": "FAHD1; C16orf36; YISKL",
        "gene_names_refseq": "C16orf36; FAHD1; ODx; YISKL",
        "protein_names_uniprotkb": "Oxaloacetate tautomerase FAHD1, mitochondrial; 3.7.1.5; 4.1.1.112; 5.3.2.2; Acylpyruvase FAHD1; FAH domain-containing protein 1; Fumarylacetoacetate hydrolase domain-containing protein 1; OAA decarboxylase; ODx; Oxaloacetate decarboxylase; YisK-like protein",
        "protein_names_refseq": "FAH domain-containing protein 1; OAA decarboxylase; YISK like/RJD15; acylpyruvase FAHD1, mitochondrial; acylpyruvate hydrolase; fumarylacetoacetate hydrolase domain containing 1; fumarylacetoacetate hydrolase domain-containing protein 1; oxaloacetate decarboxylase, mitochondrial; oxaloacetate decarboxylase; oxaloacetate tautomerase FAHD1, mitochondrial isoform 1; oxaloacetate tautomerase FAHD1, mitochondrial; yisK-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81889);  (R-HSA-70268)",
        "pathway_count": 2,
        "publication_count": 44,
        "publication_id_list": "11230166;11276087;11377399;11863375;11945601;12121650;12962632;14596586;15551868;15870898;18351441;1931970;1935931;19679512;1993674;1996957;20237496;21156174;21878618;22628558;23284632;2440048;24998673;25202825;25575590;25594249;27166188;27317664;28832583;28855257;29472561;30348641;32403431;33064660;3435492;36417180;38287013;38649439;4822737;7757881;7818469;8726225;9119391;9705294",
        "class_list": "",
        "function": "Mitochondrial enzyme FAHD1 reduces ROS in osteosarcoma. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate (PubMed:38287013). It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition (PubMed:38287013). Also acts as a weak oxaloacetate decarboxylase (ODx), catalyzing the decarboxylation of oxaloacetate (OAA) to pyruvate and CO(2), and as such is likely a regulatory enzyme in the TCA cycle (PubMed:25575590, PubMed:30348641). Also displays acylpyruvase activity, being able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro (PubMed:21878618, PubMed:30348641). Exhibits only a weak hydrolase activity on methylacetopyruvate and acetylacetone, and no activity toward acetoacetyl-CoA (PubMed:21878618)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AK40;B1AK41;Q6FIC7;Q96RY1;Q9H0N6",
        "ec_number_list": "1.1.1.38;1.1.1.40;5.3.2.2;3.7.1.5;4.1.1.112",
        "go_molecular_function": "GO:0008948 oxaloacetate decarboxylase activity;GO:0018773 acetylpyruvate hydrolase activity;GO:0034545 fumarylpyruvate hydrolase activity;GO:0047621 acylpyruvate hydrolase activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol",
        "go_biological_process": "GO:0006107 oxaloacetate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.5,
        "record_id": "Q6P587-4",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6UN15-1",
        "uniprot_id": "FIP1_HUMAN",
        "mass": 66526.0,
        "length": 594,
        "protein_name": "Pre-mRNA 3'-end-processing factor FIP1",
        "gene_name": "FIP1L1",
        "organism": "Human",
        "refseq_name": "pre-mRNA 3'-end-processing factor FIP1 isoform 2",
        "refseq_ac": "NP_001128409",
        "gene_names_uniprotkb": "FIP1L1; FIP1; RHE",
        "gene_names_refseq": "FIP1L1; FIP1; Rhe; hFip1",
        "protein_names_uniprotkb": "Pre-mRNA 3'-end-processing factor FIP1; FIP1-like 1 protein; Factor interacting with PAP; Rearranged in hypereosinophilia; hFip1",
        "protein_names_refseq": "FIP1 like 1; FIP1-like 1 protein; FIP1L1 cleavage and polyadenylation specific factor subunit; factor interacting with PAP; pre-mRNA 3'-end-processing factor FIP1 isoform 2; pre-mRNA 3'-end-processing factor FIP1; rearranged in hypereosinophilia",
        "tax_id": 9606,
        "disease": "idiopathic hypereosinophilic syndrome (MONDO:MONDO:0011895)",
        "pathway": " (hsa:81608);  (R-HSA-159231);  (R-HSA-72187);  (R-HSA-73856);  (R-HSA-77595);  (R-HSA-9673766);  (R-HSA-9770562);  (R-HSA-9918481)",
        "pathway_count": 8,
        "publication_count": 189,
        "publication_id_list": "10.1101/2023.09.13.557529;10669729;11014198;11060040;11230166;11237011;11747608;11979277;12660384;12808148;12842979;12871933;14519844;14556779;14630792;14749727;14762106;15037765;15084397;15120988;15565158;15592455;15767428;15937220;15998806;16690743;16964243;17081983;17128255;17190602;17317185;17322306;17984224;18212344;18288197;18318008;18411249;18452278;18669648;18691976;18707149;18767875;18957205;19210352;19217410;19224921;19413330;19415658;19494120;19651622;19664994;19664995;19690332;19836239;20058876;20068230;20068231;20085582;2017161;20573985;20630994;20695905;20844015;20889717;21295486;21406692;21911577;21947206;22207203;22617051;22813749;22928037;23186163;23222130;23299939;23301498;23481700;23582887;23804756;23874216;24076191;24149845;24244187;24275569;24366607;24714562;25301780;25301781;25576301;25662211;25836925;25880248;25892735;26092250;26375851;26728094;26992070;27108190;27170215;27846572;27920218;28010895;28096519;28218747;28228285;28514659;28657654;28832583;28834231;28904123;28911096;29186539;29237092;29242379;29274231;29276085;29351928;29393594;29437277;29485866;29493099;29557506;29632711;29902443;30059200;30139799;30257008;30315122;30379171;30410026;30484775;30599162;30620550;30833945;31154438;31217245;31373491;31492838;31530632;31844290;31848261;31998317;32119511;32125294;32157095;32161166;32357974;32387766;32502341;32574038;32816001;32897882;32938616;32983136;33177556;33214551;33592498;33691108;33717175;33912179;33968037;33981976;34019948;34065225;34171305;34304603;34509645;34561969;34846842;34932366;35051231;35132862;35138101;35177536;35215846;35289036;35513511;35580925;35705054;36010968;36073787;36241641;37217939;38665916;38838015;39531497;40307207;40596516;9659921",
        "class_list": "",
        "function": "Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex., [UniProtKB, PubMed]; Exquisite response to imatinib mesylate in FIP1L1-PDGFRA-mutated hypereosinophilic syndrome: a 12-year experience of the Polish Hypereosinophilic Syndrome Study Group., [RefSeq, PubMed]; FIP1L1-PDGFRA-Associated Hypereosinophilic Syndrome as a Treatable Cause of Watershed Infarction., [RefSeq, PubMed]; Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3' end biogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Observations suggest that the FIP1L1-PDGFRA rearrangement occurs in an early hematopoietic progenitor and suggests that the molecular pathogenesis for a subset of SMCD patients is similar to that of HES, [RefSeq, PubMed]; Results indicate that the fusion of FIP1L1 to PDGFRA occurs rarely in leukemia cell lines, [RefSeq, PubMed]; The hypereosinophilic syndrome may result from a novel fusion tyrosine kinase - FIP1L1-PDGFRalpha - that is a consequence of an interstitial chromosomal deletion. GeneRIF: Describes the fusion gene Fip1-like-1-PDGFRalpha in patients with idiopathic hypereosinophilic syndrome, mostly responsive to imatinib therapy., [RefSeq, PubMed]; This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 19,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 19,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 19,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 24,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 34,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 1,
        "glyco_site_count": 22,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DIR3;G3XAD6;Q0VGE0;Q499Y4;Q49AU3;Q7Z608;Q8WVN3;Q96F80;Q9H077",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex;GO:0005634 nucleus",
        "go_biological_process": "GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage;GO:0031124 mRNA 3'-end processing;GO:0006397 mRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 21.3,
        "record_id": "Q6UN15-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZU69-1",
        "uniprot_id": "S31F1_HUMAN",
        "mass": 148096.0,
        "length": 1335,
        "protein_name": "Protein SPATA31F1",
        "gene_name": "SPATA31F1",
        "organism": "Human",
        "refseq_name": "protein SPATA31F1",
        "refseq_ac": "NP_001135389",
        "gene_names_uniprotkb": "SPATA31F1; C9orf144B; FAM205A",
        "gene_names_refseq": "C9orf144B; FAM205A; SPATA31F1",
        "protein_names_uniprotkb": "Protein SPATA31F1; Protein FAM205A",
        "protein_names_refseq": "family with sequence similarity 205 member A; protein FAM205A; protein SPATA31F1; transmembrane protein C9orf144B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:259308)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "23481700;24715725;25892735;29557506;30379171;32387766;34087483;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MVW7",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q6ZU69-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7L8L6-1",
        "uniprot_id": "FAKD5_HUMAN",
        "mass": 86574.0,
        "length": 764,
        "protein_name": "Non-canonical pre-mRNAs endonuclease FASTKD5, mitochondrial",
        "gene_name": "FASTKD5",
        "organism": "Human",
        "refseq_name": "FAST kinase domain-containing protein 5, mitochondrial",
        "refseq_ac": "NP_068598",
        "gene_names_uniprotkb": "FASTKD5; KIAA1792",
        "gene_names_refseq": "FASTKD5; MC4DN24; dJ1187M17.5",
        "protein_names_uniprotkb": "Non-canonical pre-mRNAs endonuclease FASTKD5, mitochondrial; 3.1.27.-; FAST kinase domain-containing protein 5, mitochondrial",
        "protein_names_refseq": "FAST kinase domain-containing protein 5, mitochondrial",
        "tax_id": 9606,
        "disease": "mitochondrial complex IV deficiency, nuclear type 24 (MONDO:MONDO:0980755)",
        "pathway": " (hsa:60493);  (R-HSA-9837092)",
        "pathway_count": 2,
        "publication_count": 54,
        "publication_id_list": "16964243;18452278;18669648;18691976;19608861;20869947;22645359;23186163;24715725;24746820;25683715;25892735;26370583;26992070;27600516;27862975;27920218;28063628;28218747;28228285;28335001;28510447;28514659;28904123;29036396;29393594;29437277;29493099;29632046;29769354;30315122;30379171;30410026;30779550;31154438;31217245;31844290;32265295;32350084;32357974;32897882;32938616;33298915;33592498;33633747;33968037;34357683;34748562;35051231;35580925;36010968;37217939;40499538;40637235",
        "class_list": "",
        "function": "Despite the fact that proteins of the FASTK family FASTKD1-5 share the same domains, they exhibit various-sometimes opposing-functions in almost all steps of mitochondrial RNA metabolism. Review article, [RefSeq, PubMed]; Required for the processing of non-canonical mitochondrial pre-mRNAs within the primary mitochondrial polycistronic transcript, i.e. pre-mRNA sequences that are not flanked by tRNA (tRNA punctuation) (PubMed:25683715, PubMed:40499538, PubMed:40637235). Has endoribonuclease activity and processes MT-CO1, MT-CO3 and MT-CYB pre-mRNAs, generating products with 3'/2'-phosphate or a 2',3'-cyclic phosphodiester at the 3'-end (PubMed:40637235)., [UniProtKB, PubMed, PubMed, PubMed]; The FASTK family proteins fine-tune mitochondrial RNA processing. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 21,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96JN3;Q9H5D1;Q9H8Y3",
        "ec_number_list": "4.6.1.19;3.1.27.-;6.5.1.8",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0019843 rRNA binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:0035770 ribonucleoprotein granule",
        "go_biological_process": "GO:0000963 mitochondrial RNA processing;GO:0006397 mRNA processing;GO:0044528 regulation of mitochondrial mRNA stability",
        "synthesized_glycan_count": 0,
        "hit_score": 5.7,
        "record_id": "Q7L8L6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z5A8-1",
        "uniprot_id": "TAFA3_HUMAN",
        "mass": 14776.0,
        "length": 133,
        "protein_name": "Chemokine-like protein TAFA-3",
        "gene_name": "TAFA3",
        "organism": "Human",
        "refseq_name": "chemokine-like protein TAFA-3 isoform 2 precursor",
        "refseq_ac": "NP_001004440",
        "gene_names_uniprotkb": "TAFA3; FAM19A3",
        "gene_names_refseq": "FAM19A3; TAFA-3; TAFA3",
        "protein_names_uniprotkb": "Chemokine-like protein TAFA-3",
        "protein_names_refseq": "chemokine-like protein TAFA-3 isoform 2 precursor; chemokine-like protein TAFA-3; family with sequence similarity 19 (chemokine (C-C motif)-like), member A3; family with sequence similarity 19 member A3, C-C motif chemokine like; protein FAM19A3",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)",
        "pathway": " (hsa:284467)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "15028294;25576301;25595455;32387766",
        "class_list": "",
        "function": "FAM19A3 modulates the microglia/macrophage polarization dynamics and ameliorates cerebral ischemia., [RefSeq, PubMed]; Plays a role in the regulation of microglia polarization., [UniProtKB, UniProtKB]; This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZLU0;Q2M1P9;Q7Z5A6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0048018 receptor ligand activity",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:1903979 negative regulation of microglial cell activation;GO:1903980 positive regulation of microglial cell activation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q7Z5A8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N2R8-1",
        "uniprot_id": "FA43A_HUMAN",
        "mass": 45776.0,
        "length": 423,
        "protein_name": "Protein FAM43A",
        "gene_name": "FAM43A",
        "organism": "Human",
        "refseq_name": "protein FAM43A",
        "refseq_ac": "NP_710157",
        "gene_names_uniprotkb": "FAM43A; PP7298",
        "gene_names_refseq": "FAM43A",
        "protein_names_uniprotkb": "Protein FAM43A",
        "protein_names_refseq": "protein FAM43A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:131583)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "15498874;25418920;25576301;27846572;28904123;29242379;29393594;29557506;29632711;30429286;31154438;31530632;31844290;32161166;32488085;32897882;33912179;33968037;35051231;35580925;37938771",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A3KME2;Q8IXP4;Q8WZ07",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q8N2R8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N9Y4-1",
        "uniprot_id": "F181A_HUMAN",
        "mass": 38724.0,
        "length": 354,
        "protein_name": "Protein FAM181A",
        "gene_name": "FAM181A",
        "organism": "Human",
        "refseq_name": "protein FAM181A isoform 2",
        "refseq_ac": "NP_001194000",
        "gene_names_uniprotkb": "FAM181A; C14orf152; HSD-31; HSD31",
        "gene_names_refseq": "C14orf152; FAM181A",
        "protein_names_uniprotkb": "Protein FAM181A",
        "protein_names_refseq": "protein FAM181A isoform 2; protein FAM181A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:90050)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "11237011;24715725;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RD39;Q96GY1",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q8N9Y4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NFF5-1",
        "uniprot_id": "FAD1_HUMAN",
        "mass": 65266.0,
        "length": 587,
        "protein_name": "Bifunctional FAD diphosphatase/FAD synthase",
        "gene_name": "FLAD1",
        "organism": "Human",
        "refseq_name": "bifunctional FAD diphosphatase/FAD synthase isoform 3",
        "refseq_ac": "NP_001171820",
        "gene_names_uniprotkb": "FLAD1; PP591",
        "gene_names_refseq": "FAD1; FADS; FLAD1; LSMFLAD; PP591",
        "protein_names_uniprotkb": "Bifunctional FAD diphosphatase/FAD synthase; FAD pyrophosphatase; FADHy; FADPPase; FMN adenylyltransferase; FMNAT; Flavin adenine dinucleotide synthase; NADH diphosphatase",
        "protein_names_refseq": "FAD pyrophosphorylase; FAD synthase; FAD-adenylyl transferase; FAD-synthetase; FMN adenylyltransferase; Fad1, flavin adenine dinucleotide synthetase, homolog; bifunctional FAD diphosphatase/FAD synthase isoform 3; bifunctional FAD diphosphatase/FAD synthase",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162); myopathy with abnormal lipid metabolism (MONDO:MONDO:0009703)",
        "pathway": " (hsa:80308);  (R-HSA-196843)",
        "pathway_count": 2,
        "publication_count": 76,
        "publication_id_list": "11237011;12623014;15498874;16643857;16964243;17049878;18632736;18669648;18691976;19240958;19369195;20060505;20068231;20206331;20463145;21110228;21924249;21951714;23186163;23443125;23481700;23946482;24264046;24366607;24715725;25135855;25954742;26154972;26277395;26375851;26992070;27259049;27600516;2775236;27920218;28228285;28510447;28514659;28832583;28834231;28904123;29242379;29557506;29786170;30379171;30429286;30524438;31217245;31351152;31844290;32157095;32161166;32357974;32387766;32502341;32938616;33141586;33298915;33392160;33633747;33912179;33936100;33968037;34087483;34211107;34229054;34509645;35051231;36010968;36215666;36241641;36480241;38688286;39302247;40914422;8001561",
        "class_list": "",
        "function": "Our data show that a reduction in electron transport proteins, namely FAD synthetase, RFK, CYC1, and SDHB, is seen in patients with ALS., [RefSeq, PubMed]; Retrograde response to mitochondrial dysfunctions associated to LOF variations in FLAD1 exon 2: unraveling the importance of RFVT2., [RefSeq, PubMed]; Structural insights into the bifunctional enzyme human FAD synthase., [RefSeq, PubMed]; This enzyme has two activities: FAD diphosphatase activity and FAD synthase activity (PubMed:16643857, PubMed:21924249, PubMed:21951714, PubMed:23443125, PubMed:25135855, PubMed:26277395, PubMed:27259049, PubMed:31351152, PubMed:38688286). FAD diphosphatase acts on FAD and NADH to produce FMN and NMNH(2-), respectively (PubMed:26277395, PubMed:31351152, PubMed:38688286). FAD synthase catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme (PubMed:16643857, PubMed:21924249, PubMed:21951714, PubMed:23443125, PubMed:27259049, PubMed:38688286). In addition to its catalytic activities, the protein also facilitates the delivery of FAD to client apo-flavoproteins (PubMed:25954742). The balance between FAD synthesis and hydrolysis may be regulated by redox-sensing cysteine residues (PubMed:25135855, PubMed:26277395). At a much lower rate, FAD synthase catalyzes the reverse pyrophosphorolytic reaction (PubMed:21951714, PubMed:23443125, PubMed:25135855, PubMed:26277395). FAD synthase can also convert roseoflavin mononucleotide (RoFMN) to roseoflavin adenine dinucleotide (RoFAD); RoFMN is produced by riboflavin kinase when acting on the antibiotic roseoflavin (RoF) (PubMed:21924249). FAD synthase cannot convert 8-demethyl-8-amino-riboflavin mononucleotide (AFMN) to 8-demethyl-8-amino-riboflavin adenine dinucleotide (AFAD); AFMN is produced by riboflavin kinase when acting on the antibiotic 8-demethyl-8-amino-riboflavin (AF) (PubMed:21924249)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes the enzyme that catalyzes adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N5J1;Q8N686;Q8WU93;Q8WUJ4;Q96CR8;Q99764;Q9HBN6",
        "ec_number_list": "3.6.1.22;3.6.1.18;2.7.7.2;3.6.1.-",
        "go_molecular_function": "GO:0003919 FMN adenylyltransferase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0035529 NADH pyrophosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol",
        "go_biological_process": "GO:0006747 FAD biosynthetic process;GO:0006771 riboflavin metabolic process;GO:0006796 phosphate-containing compound metabolic process;GO:0090407 organophosphate biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.9,
        "record_id": "Q8NFF5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TAV0-1",
        "uniprot_id": "FA76A_HUMAN",
        "mass": 35049.0,
        "length": 307,
        "protein_name": "Protein FAM76A",
        "gene_name": "FAM76A",
        "organism": "Human",
        "refseq_name": "protein FAM76A isoform 1",
        "refseq_ac": "NP_001137384",
        "gene_names_uniprotkb": "FAM76A",
        "gene_names_refseq": "FAM76A",
        "protein_names_uniprotkb": "Protein FAM76A",
        "protein_names_refseq": "protein FAM76A isoform 1; protein FAM76A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:199870)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11237011;26992070;29242379;30379171;31844290;32488085;32897882;33592498;33912179;36581221",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DWT3;O95565;O95566;Q8N7J5",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q8TAV0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TF61-1",
        "uniprot_id": "FBX41_HUMAN",
        "mass": 94496.0,
        "length": 875,
        "protein_name": "F-box only protein 41",
        "gene_name": "FBXO41",
        "organism": "Human",
        "refseq_name": "F-box only protein 41",
        "refseq_ac": "NP_001073879",
        "gene_names_uniprotkb": "FBXO41; FBX41; KIAA1940",
        "gene_names_refseq": "FBX41; FBXO41",
        "protein_names_uniprotkb": "F-box only protein 41",
        "protein_names_refseq": "F-box only protein 41",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:150726);  (R-HSA-8951664);  (R-HSA-983168)",
        "pathway_count": 3,
        "publication_count": 144,
        "publication_id_list": "10535940;10597293;10811609;10878807;10973499;11062501;11069780;11259415;11292861;11292862;11350924;11454738;11585840;11733065;11961546;12101228;12186903;12504025;12504026;12526791;12538644;12609982;12646216;12682069;12759363;12816948;14690597;14734113;14757770;15224091;15224092;15282312;15361859;15367669;15537541;15571818;15572695;15574592;15601839;15652483;15688063;15694336;15799966;16171779;16401342;16547496;16595681;16647857;16707496;16790436;16849449;16943200;16954532;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18093314;18206966;18662542;18775313;18776931;18805092;18826954;18851830;18926707;19028597;19250909;19321346;19352404;19452197;19489725;19615748;19617556;19748355;19851334;19874575;19940261;21447816;21463634;21778237;21863050;21940857;22306028;22466964;22537386;2261476;22959436;23201271;23333871;23401859;23453757;23535662;23535663;23563313;23583660;23777664;23912815;23986495;24076655;24366543;24636985;24714562;24793695;24793696;25314029;25349211;25355947;25418920;25531226;26063905;26344709;26460955;26632597;26906416;26992070;27030794;27222660;27565346;28115426;28832583;29153394;29242379;30315122;30610225;31530632;31844290;32005965;32284348;32502341;33444648;33633747;33936100;35051231;35278439;35598880;9380723;9668046;9790970;9887101;9891082",
        "class_list": "",
        "function": "F-box protein FBXO41 plays vital role in arsenic trioxide-mediated autophagic death of cancer cells., [RefSeq, PubMed]; F-box protein FBXO41 suppresses breast cancer growth by inducing autophagic cell death through facilitating proteasomal degradation of oncogene SKP2., [RefSeq, PubMed]; Our finding suggests that the FBXO41gene may be a non-X chromosome-related Parkinson disease risk factor, [RefSeq, PubMed]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex., [UniProtKB]; This gene encodes a member of the F-box protein family, which is characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one of the four subunits of the SCF ubiquitin protein ligase complex that plays a role in phosphorylation-dependent ubiquitination. F-box proteins are divided into three classes depending on the interaction substrate domain each contains in addition to the F-box motif: FBXW proteins contain WD-40 domains, FBXL proteins contain leucine-rich repeats, and FBXO proteins contain either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the FBXO class. [provided by RefSeq, Feb 2014]., [RefSeq]; This study show that FBXO41 is a critical factor, not only for neuronal migration in the cerebellum, but also for its long-term integrity., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "G3V0Z7;Q2M1V8",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 14.5,
        "record_id": "Q8TF61-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96MZ4-1",
        "uniprot_id": "F218A_HUMAN",
        "mass": 17021.0,
        "length": 157,
        "protein_name": "Protein FAM218A",
        "gene_name": "FAM218A",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "FAM218A; C4orf39",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Protein FAM218A",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "30379171;39894887",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q96MZ4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BQN1-1",
        "uniprot_id": "FA83C_HUMAN",
        "mass": 81078.0,
        "length": 747,
        "protein_name": "Protein FAM83C",
        "gene_name": "FAM83C",
        "organism": "Human",
        "refseq_name": "protein FAM83C",
        "refseq_ac": "NP_848563",
        "gene_names_uniprotkb": "FAM83C; C20orf128",
        "gene_names_refseq": "C20orf128; FAM83C; SACK1C; dJ614O4.7",
        "protein_names_uniprotkb": "Protein FAM83C",
        "protein_names_refseq": "family with sequence similarity 83 member C; protein FAM83C",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:128876)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "18452278;24736947;27846572;28411811;29789297;30429286;35051231;35580925",
        "class_list": "",
        "function": "May play a role in MAPK signaling., [UniProtKB, PubMed]; This gene encodes a member of the family with sequence similarity 83 protein family. The encoded protein may be involved in regulating MAPK signaling in cancer cells. [provided by RefSeq, Mar 2017]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14D67;Q5JWN6;Q8N276",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019901 protein kinase binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q9BQN1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BRX8-1",
        "uniprot_id": "PXL2A_HUMAN",
        "mass": 25764.0,
        "length": 229,
        "protein_name": "Peroxiredoxin-like 2A",
        "gene_name": "PRXL2A",
        "organism": "Human",
        "refseq_name": "peroxiredoxin-like 2A isoform 1 precursor",
        "refseq_ac": "NP_001230707",
        "gene_names_uniprotkb": "PRXL2A; C10orf58; FAM213A; PAMM; PRO1198; PRO2290; PSEC0139",
        "gene_names_refseq": "Adrx; C10orf58; FAM213A; PAMM; PRXL2A",
        "protein_names_uniprotkb": "Peroxiredoxin-like 2A; Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes; Protein PAMM; Redox-regulatory protein FAM213A",
        "protein_names_refseq": "Adiporedoxin; UPF0765 protein C10orf58; family with sequence similarity 213 member A; peroxiredoxin (PRX)-like 2 activated in M-CSF stimulated monocytes; peroxiredoxin-like 2 activated in M-CSF stimulated monocytes; peroxiredoxin-like 2A isoform 1 precursor; redox-regulatory protein FAM213A; redox-regulatory protein PAMM",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84293)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "11483580;12975309;16303743;19951071;25505266;26402163;26438880;29242379;29557506;30785086;31154438;32124993;32157095;32350084;32938616;33592498;33968037;34171305;34211107;35051231;37938771",
        "class_list": "",
        "function": "Antioxidant stress induces PAMM mRNA expression in human peripheral blood mononuclear cells ., [RefSeq, PubMed]; FAM213A is linked to prognostic significance in acute myeloid leukemia through regulation of oxidative stress and myelopoiesis., [RefSeq, PubMed]; Involved in redox regulation of the cell (PubMed:19951071, PubMed:26438880). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880)., [UniProtKB, PubMed, PubMed]; Results suggest that adipocyte-derived PAMM may suppress macrophage activation by inhibiting MAPK signalling pathway., [RefSeq, PubMed]; The PAMM is a redox regulatory protein that modulates osteoclast differentiation in vitro. PAMM expression may affect bone resorption in vivo and help to maintain bone mass., [RefSeq, PubMed]; This study has pinpointed novel clues demonstrating that downregulation of miR-125b suppressor underlies upregulation of PRXL2A in OSCC, and this then protects the affected tumor cells from oxidative stress., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RD81;Q6UW08;Q8N2K3;Q8NBK9;Q96JR0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0016209 antioxidant activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0045670 regulation of osteoclast differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q9BRX8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BSK4-1",
        "uniprot_id": "FEM1A_HUMAN",
        "mass": 73639.0,
        "length": 669,
        "protein_name": "Protein fem-1 homolog A",
        "gene_name": "FEM1A",
        "organism": "Human",
        "refseq_name": "protein fem-1 homolog A",
        "refseq_ac": "NP_061178",
        "gene_names_uniprotkb": "FEM1A; EPRAP",
        "gene_names_refseq": "EPRAP; FEM1A",
        "protein_names_uniprotkb": "Protein fem-1 homolog A; FEM1-alpha; FEM1a; Prostaglandin E receptor 4-associated protein",
        "protein_names_refseq": "FEM1-alpha; prostaglandin E receptor 4-associated protein; protein fem-1 homolog A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55527);  (R-HSA-8951664)",
        "pathway_count": 2,
        "publication_count": 164,
        "publication_id_list": "10.1101/2023.09.13.557529;10535940;10597293;10811609;10878807;10973499;11069780;11259415;11292861;11292862;11454738;11585840;11733065;11961546;12101228;12186903;12504025;12504026;12526791;12538644;12609982;12682069;12759363;12816948;14690597;14757770;15282312;15361859;15367669;15537541;15572695;15574592;15601839;15652483;15688063;15694336;15799966;16171779;16254458;16390781;16401342;16424369;16547496;16647857;16707496;16790436;16943200;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18093314;18206966;18775313;18776931;18805092;18826954;18851830;18926707;19250909;19321346;19406122;19617556;19748355;21447816;21463634;21778237;21863050;21940857;22306028;22466964;22537386;22959436;23201271;23333871;23401859;23453757;23481700;23535662;23535663;23563313;23583660;23912815;23986495;24076655;24366543;24636985;24793695;24793696;25314029;25349211;25355947;25418920;25531226;25576301;25645385;26154972;26344709;26375851;26460955;26632597;26906416;26929215;26992070;27030794;27222660;27565346;27600516;27726376;27846572;27920218;28115426;28118078;28228285;28832583;28904123;29153394;29331515;29393594;29557506;29632046;29779948;30429286;30524438;30610225;31217245;31222486;31530632;31844290;31848261;32005965;32157095;32161166;32265295;32284348;32357974;32387766;32488085;32938616;32983136;33141586;33298915;33398168;33398170;33444648;33537174;33592498;33691108;33968037;33981976;34087483;34171305;34509645;35051231;35580925;36010968;36241641;39894887;9790970;9887101;9891082",
        "class_list": "",
        "function": "FEM1 proteins are ancient regulators of Stem-Loop Binding Protein., [RefSeq, PubMed]; Fem1a downregulation may be involved in, and/or a marker of, an early cell fate defect fundamental to rhabdomyosarcoma pathogenesis, [RefSeq, PubMed]; Molecular basis for arginine C-terminal degron recognition by Cul2(FEM1) E3 ligase., [RefSeq, PubMed]; Molecular basis for ubiquitin ligase CRL2(FEM1C)-mediated recognition of C-degron., [RefSeq, PubMed]; Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:33398168, PubMed:33398170). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:33398168, PubMed:33398170). The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (PubMed:33398168, PubMed:33398170). Promotes ubiquitination and degradation of SLBP (PubMed:28118078). Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4 (By similarity). Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDI3;Q711P8;Q9NPN7;Q9NPW8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031867 EP4 subtype prostaglandin E2 receptor binding;GO:0060090 molecular adaptor activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005829 cytosol",
        "go_biological_process": "GO:0050728 negative regulation of inflammatory response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050729 positive regulation of inflammatory response;GO:0016567 protein ubiquitination;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 16.9,
        "record_id": "Q9BSK4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BTP7-1",
        "uniprot_id": "FAP24_HUMAN",
        "mass": 23897.0,
        "length": 215,
        "protein_name": "Fanconi anemia core complex-associated protein 24",
        "gene_name": "FAAP24",
        "organism": "Human",
        "refseq_name": "Fanconi anemia core complex-associated protein 24 isoform 2",
        "refseq_ac": "NP_001287907",
        "gene_names_uniprotkb": "FAAP24; C19orf40",
        "gene_names_refseq": "C19orf40; FAAP24",
        "protein_names_uniprotkb": "Fanconi anemia core complex-associated protein 24; Fanconi anemia-associated protein of 24 kDa",
        "protein_names_refseq": "Fanconi anemia core complex associated protein 24; Fanconi anemia core complex-associated protein 24 isoform 2; Fanconi anemia-associated protein of 24 kDa",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91442);  (R-HSA-6783310);  (R-HSA-9833482)",
        "pathway_count": 3,
        "publication_count": 193,
        "publication_id_list": "10082513;10348343;10400669;10620360;10626894;10648614;10848580;10866685;11096080;11134010;11152499;11156368;11237011;11238103;11238927;11239454;11278865;11313968;11337501;11350938;11438540;11500375;11781817;11909525;11939789;11985496;12231563;12397061;12882984;1373135;14585331;15229216;15299030;15572677;15737233;15752359;15907845;16179258;16179259;16373505;16431927;16600570;16717090;16916645;16943440;1695551;16982605;17079286;17196820;17289582;17412408;17460694;17938197;18082604;18096616;18174376;18206976;18835251;18931676;18957415;18995830;19111657;19229320;19416861;19561358;19589784;19596236;19710021;19733181;19804757;19838063;19995904;20102227;20347428;20347429;20385554;20395957;20519500;20603015;20603016;20603073;20670894;20671156;20685959;21072047;21123651;21294215;21464321;21518807;21636578;21701511;21764741;21937648;21978664;21994559;22214662;22258451;22287633;22396592;2247437;22510687;22692201;22986343;23084476;23229543;23325218;23481700;23698467;23723247;23732991;24003026;24076221;24347309;24389026;24623135;24623813;24659800;24726325;24753571;24905007;25430771;25500724;25653431;25848059;25892735;26432638;26446704;26488609;26716879;26817845;27208315;27269119;27423063;27473539;27974558;28069888;28167698;28281686;28765891;29170442;29175459;29231267;29348664;29394925;29395325;29440070;29501855;30174290;30379171;30770398;31031002;31844290;31998317;32093270;32157095;32357974;32716602;32801355;32938616;33298915;33808629;33911136;33968037;34171305;34174402;34405274;34974812;35685460;35947956;36010968;36712380;37127961;7491766;7515177;7545299;7565688;7693978;7737357;7903669;8576172;8576179;8661426;8810342;8910500;9034343;9079663;9442054;9521856;9528799;9687506;9737981;9819388;9920933",
        "class_list": "",
        "function": "DNA damage recognition and remodeling activities of FANCM and FAAP24 cooperate to promote efficient activation of DNA damage checkpoints in Fanconi anemia., [RefSeq, PubMed]; FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]., [RefSeq]; FAAP24 is dispensable for DNA binding and branch migration activity of FANCM., [RefSeq, PubMed]; FAAP24 targets FANCM to structures that mimic intermediates formed during the replication/repair of damaged DNA., [RefSeq, PubMed]; FANCM is an anchor required for recruitment of the FA core complex to chromatin, and the FANCM/FAAP24 interaction is essential for this chromatin-loading activity, [RefSeq, PubMed]; Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA., [UniProtKB, PubMed]; Results show that the first HhH motif of FAAP24 is a potential binding site for DNA, which plays a critical role in targeting FANCM-FAAP24 to chromatin., [RefSeq, PubMed]; This is the first report of an FAAP24 loss of function mutation found in human patients with EBV-associated lymphoproliferation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KY46;Q8WUJ7;Q96FX6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding",
        "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin",
        "go_biological_process": "GO:0036297 interstrand cross-link repair",
        "synthesized_glycan_count": 0,
        "hit_score": 19.6,
        "record_id": "Q9BTP7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9GZV9-1",
        "uniprot_id": "FGF23_HUMAN",
        "mass": 27954.0,
        "length": 251,
        "protein_name": "Fibroblast growth factor 23",
        "gene_name": "FGF23",
        "organism": "Human",
        "refseq_name": "fibroblast growth factor 23 precursor",
        "refseq_ac": "NP_065689",
        "gene_names_uniprotkb": "FGF23; HYPF; PRO9828",
        "gene_names_refseq": "ADHR; FGF23; FGFN; HFTC2; HPDR2; HYPF; PHPTC",
        "protein_names_uniprotkb": "Fibroblast growth factor 23; FGF-23; Phosphatonin; Tumor-derived hypophosphatemia-inducing factor",
        "protein_names_refseq": "fibroblast growth factor 23 precursor; phosphatonin; tumor-derived hypophosphatemia inducing factor",
        "tax_id": 9606,
        "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); autosomal dominant hypophosphatemic rickets (Disease Ontology:DOID:0050948); uremia (Disease Ontology:DOID:4676); chronic kidney disease (Disease Ontology:DOID:784); tumoral calcinosis, hyperphosphatemic, familial, 2 (MONDO:MONDO:0060714)",
        "pathway": " (hsa:8074);  (R-HSA-109704);  (R-HSA-1257604);  (R-HSA-1839122);  (R-HSA-1839130);  (R-HSA-190322);  (R-HSA-190372);  (R-HSA-190373);  (R-HSA-190374);  (R-HSA-190375);  (R-HSA-2033519);  (R-HSA-2219530);  (R-HSA-381426);  (R-HSA-5654219);  (R-HSA-5654221);  (R-HSA-5654227);  (R-HSA-5654228);  (R-HSA-5654687);  (R-HSA-5654688);  (R-HSA-5654689);  (R-HSA-5654693);  (R-HSA-5654695);  (R-HSA-5654699);  (R-HSA-5654700);  (R-HSA-5654704);  (R-HSA-5654706);  (R-HSA-5654710);  (R-HSA-5654712);  (R-HSA-5654719);  (R-HSA-5654720);  (R-HSA-5654726);  (R-HSA-5654727);  (R-HSA-5654732);  (R-HSA-5654733);  (R-HSA-5655253);  (R-HSA-5655302);  (R-HSA-5655332);  (R-HSA-5658623);  (R-HSA-5673001);  (R-HSA-6811558);  (R-HSA-8957275)",
        "pathway_count": 41,
        "publication_count": 347,
        "publication_id_list": "10026136;10053006;10077652;10191262;10218588;10490103;10508167;10512690;10574949;10579907;10614670;10618369;10629055;10652257;10681634;10810289;10869344;10898936;10912521;10918587;10951195;10990447;11027663;11032749;11055896;11062477;11090077;11121055;11136978;11147812;11157491;11157998;11158056;11250653;11264294;11294897;11297579;11313946;11316783;11344269;11353842;11409890;11418238;11429702;11447289;11463336;11522292;11546808;11606061;11606067;11689702;11702783;11737582;11739083;11739186;11751371;11781872;11788658;11803464;11997436;12009017;12032311;12094235;12112473;12121613;12130585;12167717;12241545;12379487;12419216;12461689;12466191;12627230;12660731;12767043;12810533;12815057;12904166;12952917;12974390;12975309;1325671;1353055;1370451;1379698;1381348;1383255;14506247;14534538;14613973;14688794;14707138;14715624;14871245;15029211;15040831;15050920;15094036;15126567;15268897;15282208;15308688;15324302;15340161;15356145;15448205;1545823;15469690;15485880;15525596;15546878;15548653;15590700;15598814;15642270;15718470;15834429;15863029;15863030;15880580;16030159;16091734;16140923;16151858;16186508;16339315;16456541;16467200;16507368;16532037;1656221;16597617;16627759;16638743;16647110;16684964;16764984;16844695;16847462;16872596;1697263;17047378;17086194;1716764;17200115;17227708;17249697;17312271;17339340;17344846;17505008;17525745;17552943;17626883;17698633;17803937;17985932;17998941;18056464;18061161;18079394;18282132;18317450;18337450;18373495;18381441;18412956;18452557;18552176;18594509;18606717;18754654;18755892;18757403;18757432;18772890;18775330;18829560;18840094;18925875;18985070;1898771;19103595;19147536;19185485;19187780;19224897;19279408;19381019;19411071;19438505;19576174;19644473;19652666;19696444;19715689;19749790;19805105;19809159;19855393;19920134;19920141;19946327;19962665;20094046;20106510;20117945;20179196;20231295;20338997;20421966;20478380;20522708;20709759;20713702;21102635;21160078;21188471;21317208;21367659;21368164;21372320;21478295;21616146;21666749;21668414;21711248;21779497;21779505;21827948;21976531;21984976;21993244;22120714;22188813;22432025;22569528;22588880;22589270;22750304;22802525;22802530;22837387;23103841;23112089;23175443;23298836;23303910;23443682;23558953;23575685;23640895;24026051;24588013;24680727;24706917;2476804;2479552;24897931;24937142;25219551;25467007;25781681;26085527;26091039;28063628;28218747;28778966;29437277;31135801;31932717;38791495;39054573;5173181;6148751;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7543144;7559490;7588299;7637810;7647778;7683646;7689487;7719344;7744773;7773297;7809086;7874169;7935463;7972015;8052307;8264585;8394845;8493579;8589699;8599935;8622701;8640234;8645157;8657148;8663044;8665852;8710374;8754806;8755573;8780727;8781553;8798788;8817670;8841188;8845844;8894645;8939933;8964575;9024275;9045692;9139660;9154000;9182757;9279753;9299490;9438390;9480847;9497324;9502772;9538690;9539778;9604935;9632781;9660748;9700203;9709957;9730987;9733769;9736715;9786878;9857065;9895304;9922210;9927426",
        "class_list": "glycogene",
        "function": "Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23, [RefSeq, PubMed]; FGF23 as a Potential Pathophysiological Factor in Peripheral Arterial Disease Associated with Chronic Kidney Disease. Publication Status: Online-Only, [RefSeq, PubMed]; FGF23 mutations cause autosomal dominant hypophosphatemic rickets (ADHR), [RefSeq, PubMed]; Fibroblast growth factor 23-mediated regulation of osteoporosis: Assessed via Mendelian randomization and in vitro study., [RefSeq, PubMed]; Regulator of phosphate homeostasis (PubMed:11062477). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (PubMed:11409890). Up-regulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism (PubMed:15040831). Negatively regulates osteoblast differentiation and matrix mineralization (PubMed:18282132)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 2,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 422,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4V758",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005105 type 1 fibroblast growth factor receptor binding;GO:0008083 growth factor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005788 endoplasmic reticulum lumen;GO:0005796 Golgi lumen",
        "go_biological_process": "GO:0042369 vitamin D catabolic process;GO:0010966 regulation of phosphate transport;GO:1904383 response to sodium phosphate;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 35.0,
        "record_id": "Q9GZV9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NVQ4-1",
        "uniprot_id": "FAIM1_HUMAN",
        "mass": 20215.0,
        "length": 179,
        "protein_name": "Fas apoptotic inhibitory molecule 1",
        "gene_name": "FAIM",
        "organism": "Human",
        "refseq_name": "fas apoptotic inhibitory molecule 1 isoform a",
        "refseq_ac": "NP_001028202",
        "gene_names_uniprotkb": "FAIM; FAIM1",
        "gene_names_refseq": "FAIM1; FAIM",
        "protein_names_uniprotkb": "Fas apoptotic inhibitory molecule 1",
        "protein_names_refseq": "fas apoptotic inhibitory molecule 1 isoform a; fas apoptotic inhibitory molecule 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55179)",
        "pathway_count": 1,
        "publication_count": 51,
        "publication_id_list": "11237011;12107411;17912957;17942717;22898188;23481700;25645385;26375851;26992070;28510447;28832583;28834231;28904123;29242379;29331515;29557506;29769354;29786170;30379171;30429286;30524438;30779550;31222486;31844290;32157095;32161166;32387766;32488085;32502341;32897882;32938616;33249986;33298915;33537174;33592498;33691108;33936100;33968037;33981976;34087483;34171305;34405274;34509645;34720024;35051231;35318648;35561310;35580925;36010968;36215666;36233145",
        "class_list": "",
        "function": "Expression of the long form of Fas apoptotic inhibitory molecule (FAIML) results in the protection of neurons from the cytotoxic actions of death ligands., [RefSeq, PubMed]; FAIM regulates autophagy through glutaminolysis in lung adenocarcinoma., [RefSeq, PubMed]; FAIM-S functions as a negative regulator of NF-kappaB pathway and blocks cell cycle progression in NSCLC cells., [RefSeq, PubMed]; Human keratinocytes were transfected with either Flip, Faim, or Lifeguard (LFG). Our results suggest that heterotopic expression of antiapoptotic proteins can induce the resistance of keratinocytes to a major mechanism of rejection., [RefSeq, PubMed]; Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells., [UniProtKB]; Small Heat Shock Proteins Collaborate with FAIM to Prevent Accumulation of Misfolded Protein Aggregates. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene protects against death receptor-triggered apoptosis and regulates B-cell signaling and differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IAN2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006915 apoptotic process;GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0043066 negative regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q9NVQ4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UPT5-3",
        "uniprot_id": "EXOC7_HUMAN",
        "mass": 83382.0,
        "length": 735,
        "protein_name": "Exocyst complex component 7",
        "gene_name": "EXOC7",
        "organism": "Human",
        "refseq_name": "exocyst complex component 7 isoform 1",
        "refseq_ac": "NP_001013861",
        "gene_names_uniprotkb": "EXOC7; EXO70; KIAA1067",
        "gene_names_refseq": "2-5-3p; BLOM4; EX070; EXO70; EXOC7; Exo70p; NEDSEBA; YJL085W",
        "protein_names_uniprotkb": "Exocyst complex component 7; Exocyst complex component Exo70",
        "protein_names_refseq": "exocyst complex component 7 isoform 1; exocyst complex component Exo70",
        "tax_id": 9606,
        "disease": "microcephaly (Disease Ontology:DOID:10907); neurodevelopmental disorder with seizures and brain atrophy (MONDO:MONDO:0033658)",
        "pathway": " (hsa:23265);  (R-HSA-1445148);  (R-HSA-264876);  (R-HSA-5620916)",
        "pathway_count": 4,
        "publication_count": 150,
        "publication_id_list": "10521251;11462236;11493706;11707400;11904301;12221131;14617756;14704853;15158452;1528899;15331542;15728366;15878854;15919790;15971998;16038802;16136078;16148947;16155582;16158220;16158222;16213214;16407158;16431365;16537653;16714477;16782012;16880201;16984975;17007872;17030804;17369524;17574030;17628206;17646400;17956946;17995453;18685082;19013499;19017632;19153612;19252894;19297529;19454479;20083215;20308425;20308558;20631154;20701589;20837646;20937701;21091435;21145486;21273506;21308844;21454505;21454690;21550243;21565611;21713314;21775626;21907143;22389062;22420621;22433857;22595671;22983554;23351793;23567335;23945166;24296415;24366607;25091901;25418920;2550440;25576301;25892735;26375851;2669954;26811146;26929215;26992070;27846572;27920218;2822027;28411811;28832583;28904123;29242379;29493099;29557506;29786170;30315122;30379171;30410026;30779550;30833945;30917119;31154438;31184304;31217245;31530632;31844290;31848261;31913283;31998317;32103185;32157095;32161166;32357974;32387766;32488085;32502341;32723473;32938616;32983136;33123756;33298915;33485965;33537174;33542212;33592498;33691108;33717175;33783995;33912179;33936100;33968037;33981976;34087483;34171305;34509645;34561969;34932366;35051231;35318648;35580925;36010968;36284347;37938771;3896518;39146185;7626024;8094051;8664345;8916141;9166668;9207799;9631292;9819391",
        "class_list": "",
        "function": "A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3. Publication Status: Online-Only, [RefSeq, PubMed]; Androgen receptor decreases renal cell carcinoma bone metastases via suppressing the osteolytic formation through altering a novel circEXOC7 regulatory axis., [RefSeq, PubMed]; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). It is required for neuron survival and plays an essential role in cortical development (By similarity)., [UniProtKB, UniProtKB]; TGM1/3-mediated transamidation of Exo70 promotes tumor metastasis upon LKB1 inactivation., [RefSeq, PubMed]; The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5MC69;B8XXP2;Q8ND93;Q8WV91;Q96FF0;Q9H8C3;Q9H9X3;Q9HA32",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0030674 protein-macromolecule adaptor activity",
        "go_cellular_component": "GO:0032584 growth cone membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005815 microtubule organizing center",
        "go_biological_process": "GO:2000535 regulation of entry of bacterium into host cell;GO:1903438 positive regulation of mitotic cytokinetic process;GO:0015031 protein transport;GO:0016241 regulation of macroautophagy;GO:0000281 mitotic cytokinesis",
        "synthesized_glycan_count": 0,
        "hit_score": 15.3,
        "record_id": "Q9UPT5-3",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P23434-1",
        "uniprot_id": "GCSH_HUMAN",
        "mass": 18885.0,
        "length": 173,
        "protein_name": "Glycine cleavage system H protein, mitochondrial",
        "gene_name": "GCSH",
        "organism": "Human",
        "refseq_name": "glycine cleavage system H protein, mitochondrial precursor",
        "refseq_ac": "NP_004474",
        "gene_names_uniprotkb": "GCSH",
        "gene_names_refseq": "GCE; GCSH; MMDS7; NKH",
        "protein_names_uniprotkb": "Glycine cleavage system H protein, mitochondrial; Lipoic acid-containing protein",
        "protein_names_refseq": "glycine cleavage system H protein, mitochondrial precursor; glycine cleavage system protein H (aminomethyl carrier); lipoic acid-containing protein; mitochondrial glycine cleavage system H-protein",
        "tax_id": 9606,
        "disease": "multiple mitochondrial dysfunctions syndrome (Disease Ontology:DOID:0070330); multiple mitochondrial dysfunctions syndrome 7 (Disease Ontology:DOID:0070733); amino acid metabolic disorder (Disease Ontology:DOID:9252); glycine encephalopathy (Disease Ontology:DOID:9268)",
        "pathway": " (hsa:2653);  (R-HSA-6783984);  (R-HSA-9857492)",
        "pathway_count": 3,
        "publication_count": 36,
        "publication_id_list": "10103005;11237011;11389890;16051266;16263718;1671321;19570983;1959641;1993704;2025283;21846720;22152680;24256811;24341803;25880248;26811146;28228285;28757203;28904123;29987032;30337557;31042466;31844290;32357974;33890291;33936100;33968037;34357683;35008409;36190515;36215666;36241641;37453661;37481209;6469978;9242632",
        "class_list": "",
        "function": "Biallelic start loss variant, c.1A > G in GCSH is associated with variant nonketotic hyperglycinemia., [RefSeq, PubMed]; Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome.[provided by RefSeq, Jan 2010]., [RefSeq]; GCSH protein is overexpressed in both, breast cancer tissue and breast cancer cell lines. A shorter (391 bp) transcript variant (Tv*) was amplified with an increased expression in healthy breast cells and a decreased expression in breast cancer samples. A GCSH-equilibrium at the transcript level is likely conceivable for optimal glycine degradation. Publication Status: Online-Only, [RefSeq, PubMed]; Pathogenic variants in GCSH encoding the moonlighting H-protein cause combined nonketotic hyperglycinemia and lipoate deficiency., [RefSeq, PubMed]; The H protein shuttles the methylamine group of glycine from the P protein to the T protein., [UniProtKB, UniProtKB, UniProtKB]; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Has a pivotal role in the lipoylation of enzymes involved in cellular energetics such as the mitochondrial dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (DLAT), and the mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (DLST)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9H1E9",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005960 glycine cleavage complex",
        "go_biological_process": "GO:0019464 glycine decarboxylation via glycine cleavage system",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "P23434-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A2VDF0-1",
        "uniprot_id": "FUCM_HUMAN",
        "mass": 16765.0,
        "length": 154,
        "protein_name": "Fucose mutarotase",
        "gene_name": "FUOM",
        "organism": "Human",
        "refseq_name": "fucose mutarotase isoform 1",
        "refseq_ac": "NP_001091953",
        "gene_names_uniprotkb": "FUOM; C10orf125",
        "gene_names_refseq": "C10orf125; FUCU; FUOM; FucM",
        "protein_names_uniprotkb": "Fucose mutarotase; 5.1.3.29",
        "protein_names_refseq": "fucose mutarotase isoform 1; protein fucU homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:282969);  (R-HSA-6787639)",
        "pathway_count": 2,
        "publication_count": 38,
        "publication_id_list": "11237011;11326280;12056818;12753898;16086588;16385451;17602138;23774504;23922970;25576301;26154972;26992070;27600516;27738779;27846572;27862975;28832583;28834231;28904123;29242379;29557506;29786170;30315122;31844290;32157095;32161166;32387766;32938616;32983136;33717175;33936100;34509645;34561969;35318648;35580925;8910301;9525924;9603974",
        "class_list": "",
        "function": "Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L300;Q5VWY2;Q5VWY3;Q6ZPD2",
        "ec_number_list": "5.1.3.29",
        "go_molecular_function": "GO:0042806 fucose binding;GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives;GO:0036373 L-fucose mutarotase activity;GO:0048029 monosaccharide binding",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0042352 GDP-L-fucose salvage;GO:0006004 fucose metabolic process;GO:0005996 monosaccharide metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "A2VDF0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A6NER3-1",
        "uniprot_id": "GG12J_HUMAN",
        "mass": 12897.0,
        "length": 117,
        "protein_name": "G antigen 12J",
        "gene_name": "GAGE12J",
        "organism": "Human",
        "refseq_name": "G antigen 12J",
        "refseq_ac": "NP_001091876",
        "gene_names_uniprotkb": "GAGE12J",
        "gene_names_refseq": "GAGE11; GAGE12J",
        "protein_names_uniprotkb": "G antigen 12J; GAGE-12J",
        "protein_names_refseq": "G antigen 11; G antigen 12J",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:729396)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "18179644",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "A6NER3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A8MZA4-1",
        "uniprot_id": "GG6L6_HUMAN",
        "mass": 90952.0,
        "length": 724,
        "protein_name": "Golgin subfamily A member 6-like protein 6",
        "gene_name": "GOLGA6L6",
        "organism": "Human",
        "refseq_name": "golgin subfamily A member 6-like protein 6",
        "refseq_ac": "NP_001138476",
        "gene_names_uniprotkb": "GOLGA6L6",
        "gene_names_refseq": "GOLGA6L6",
        "protein_names_uniprotkb": "Golgin subfamily A member 6-like protein 6",
        "protein_names_refseq": "golgi autoantigen, golgin subfamily a, 6-like 6; golgin subfamily A member 6-like protein 6; putative golgin subfamily A member 6-like protein 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:727832)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "30620550;37217939",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3YTC0",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "A8MZA4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UG22-1",
        "uniprot_id": "GIMA2_HUMAN",
        "mass": 38017.0,
        "length": 337,
        "protein_name": "GTPase IMAP family member 2",
        "gene_name": "GIMAP2",
        "organism": "Human",
        "refseq_name": "GTPase IMAP family member 2",
        "refseq_ac": "NP_056475",
        "gene_names_uniprotkb": "GIMAP2; IMAP2",
        "gene_names_refseq": "GIMAP2; HIMAP2; IAN12; IMAP2",
        "protein_names_uniprotkb": "GTPase IMAP family member 2; Immunity-associated protein 2; hIMAP2",
        "protein_names_refseq": "GTPase IMAP family member 2; immune-associated nucleotide-binding protein 12; immunity associated protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26157)",
        "pathway_count": 1,
        "publication_count": 29,
        "publication_id_list": "11237011;18491316;20237496;20516611;21059949;23454188;24715725;27846572;27862975;27920218;28218747;28228285;28832583;28904123;29242379;29437277;30429286;31154438;31530632;31844290;31848261;32157095;32938616;32983136;33141586;33298915;34357683;35051231;35580925",
        "class_list": "",
        "function": "GDP-bound GIMAP2(21-260) and GDP-bound GIMAP2(1-234) crystallized in space group P2(1)2(1)2(1) and the crystals diffracted X-rays to 2.9 and 1.7 A resolution, respectively., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself., [UniProtKB, PubMed]; This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96L25",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "Q9UG22-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00591-1",
        "uniprot_id": "GBRP_HUMAN",
        "mass": 50640.0,
        "length": 440,
        "protein_name": "Gamma-aminobutyric acid receptor subunit pi",
        "gene_name": "GABRP",
        "organism": "Human",
        "refseq_name": "gamma-aminobutyric acid receptor subunit pi isoform 1 precursor",
        "refseq_ac": "NP_055026",
        "gene_names_uniprotkb": "GABRP",
        "gene_names_refseq": "GABRP",
        "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit pi; GABA(A) receptor subunit pi; GABAAR subunit pi",
        "protein_names_refseq": "GABA(A) receptor subunit pi; GABA(A) receptor, pi; GABAAR subunit pi; gamma-aminobutyric acid (GABA) A receptor, pi; gamma-aminobutyric acid receptor subunit pi isoform 1 precursor; gamma-aminobutyric acid receptor subunit pi; gamma-aminobutyric acid type A receptor pi subunit",
        "tax_id": 9606,
        "disease": "epilepsy (Disease Ontology:DOID:1826)",
        "pathway": " (hsa:2568)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "10462548;11237011;16172613;16959974;24715725;25576301;25892735;26992070;28904123;29786170;30429286;30484775;30779550;31217245;32359161;33592498;34023418;34185709;34790061;35051231;35846884;36284347;37326897;9182563",
        "class_list": "",
        "function": "GABRP Promotes the Metastasis of Pancreatic Cancer by Activation of the MEK/ERK Signaling Pathway., [RefSeq, PubMed]; GABRP promotes CD44s-mediated gemcitabine resistance in pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; GABRP sustains the stemness of triple-negative breast cancer cells through EGFR signaling., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Pi subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA) (PubMed:10462548). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:10462548). Pi-containing GABAARs are mostly located in peripheral tissues. In the uterus, pi subunits modulate uterus contraction by altering the sensitivity of GABAARs to pregnanolone (PubMed:9182563). In the lungs, pi-containing GABAARs contribute to pulmonary fluid transport via luminal secretion of chloride (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The Emerging Roles of pi Subunit-Containing GABAA Receptors in Different Cancers. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]., [RefSeq]; Use of a human embryonic stem cell model to discover GABRP, WFDC2, VTCN1 and ACTC1 as markers of early first trimester human trophoblast., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 34,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KA36;D3DQL2;Q32MJ1",
        "ec_number_list": "1.8.-.-;1.8.5.1;1.11.1.-;5.6.1.6",
        "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:0005230 extracellular ligand-gated monoatomic ion channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0016324 apical plasma membrane;GO:0034707 chloride channel complex;GO:1902711 GABA-A receptor complex",
        "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:0006811 monoatomic ion transport",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "O00591-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P52566-1",
        "uniprot_id": "GDIR2_HUMAN",
        "mass": 22988.0,
        "length": 201,
        "protein_name": "Rho GDP-dissociation inhibitor 2",
        "gene_name": "ARHGDIB",
        "organism": "Human",
        "refseq_name": "rho GDP-dissociation inhibitor 2",
        "refseq_ac": "NP_001166",
        "gene_names_uniprotkb": "ARHGDIB; GDIA2; GDID4; RAP1GN1",
        "gene_names_refseq": "ARHGDIB; D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1; RhoGDI2",
        "protein_names_uniprotkb": "Rho GDP-dissociation inhibitor 2; Ly-GDI; Rho GDI 2; Rho-GDI beta",
        "protein_names_refseq": "Rho GDI 2; Rho GDP dissociation inhibitor (GDI) beta; rho GDP-dissociation inhibitor 2; rho-GDI beta",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:397);  (R-HSA-8980692);  (R-HSA-9013148);  (R-HSA-9013149);  (R-HSA-9013407);  (R-HSA-9013408);  (R-HSA-9013423)",
        "pathway_count": 7,
        "publication_count": 417,
        "publication_id_list": "10037681;10232922;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10618392;10619026;10652265;10655614;10699171;10699464;10724160;10802295;10873388;10873802;10958683;11007481;11058585;11085924;11149925;11207612;11237011;11306516;11368848;11373293;11396949;11431473;11432776;11584276;11606631;11672528;11680691;11689693;11696321;11704860;11707441;11756552;11773441;11803464;11804587;11804589;11804590;11809807;11864571;11884391;11912491;11948177;11956649;11961559;11967128;12071859;12093360;12096337;12172552;12177196;12195014;12221077;12221096;12351724;12376551;12432077;12464619;12531887;12546821;12547822;12650940;12665586;12773384;12857875;12860998;12877655;12907671;12923183;14506234;14512443;14514689;1464587;14675773;14718541;15023524;15033976;15064355;15107133;15133129;15147912;15157669;15260990;15302923;15304341;15339924;15342493;15485661;15507211;15579468;15592455;15601624;15611138;15728722;15850391;15858067;15866170;15897194;16002401;16112081;16116428;16184169;16217026;16243036;16339170;16467373;16473593;16492808;16507994;16519628;16630611;16636067;16702231;16714282;16762923;16776779;16777452;16777849;16862148;16896804;16914516;16968698;17027967;17028588;17064668;17077126;17145773;17196961;17214551;17244649;17562871;17583407;17599059;17702745;17765681;17804252;17932950;17942708;17976533;18006505;18045877;18056264;18158243;18218625;18249095;18347018;18363964;18396277;18426980;18512783;18653540;18697831;18786931;18829452;18835169;18838382;18929667;19054851;19269969;19321744;19494238;19534724;19581409;19605563;19608861;19635168;19673492;19690332;19713215;19934221;20030946;20101212;20184954;20400958;20460433;20591975;20628200;20660154;20679435;20810653;20851766;21081667;21148482;21351730;21454492;21542010;21565175;21613211;21621533;21685891;21699497;21730051;21865595;21936715;21989057;22004470;22096251;2226408;22298643;22305756;22407364;22461490;22469974;22475431;22571869;22608513;22673745;22734669;22911862;22970203;22992742;23200924;23209303;23255595;23288169;23328677;23406282;23434736;23481700;23572525;23707487;23718289;23719902;23870313;23940355;24086303;24128008;24259668;24335996;24352656;24584464;24659802;24715725;24859002;24933155;24960694;24996924;25024229;25211221;25418920;25428919;25502872;25576301;25704760;25721503;25795300;25862245;25892735;25963737;26129894;26154972;26299518;26371245;26375851;26529257;26598554;26628301;26887924;26992070;27096001;27117132;27145964;27216196;27481945;27555588;27566826;27713499;27798618;27806292;27846572;27862975;27920218;27986909;28028151;28063628;28112683;28114311;28196833;28218747;28228285;28356423;28467828;28584191;28825699;28832583;28834231;28860633;28904123;29089502;29146911;29242379;29351928;29358323;29382922;29393594;29437277;29493099;29508533;29510700;29557506;29632046;29632711;29774024;29786170;29789417;30061681;30315122;30379171;30429286;30524438;30573663;30853411;31020640;31105010;31154438;31530632;31611695;31844290;31848261;31871319;32157095;32176626;32203420;32265295;32350084;32357974;32387766;32502341;32860848;32897882;32903764;32983136;33043033;33091337;33392160;33912179;33968037;34171305;34357683;34433824;34437633;34509645;34932366;35051231;35154160;35251023;35561310;35580925;36284347;37938771;38334664;38376344;7476457;7479768;7512369;7559638;7673236;7721814;7753201;7835339;8021274;8107774;8262133;8356058;8434008;8537347;8543060;8571126;8617235;8643598;8645157;8649427;8662891;8670801;8756646;8769096;8798539;8805223;8807639;8810315;8816443;8939998;8990121;8994827;9013646;9099726;9111050;9113980;9252344;9268338;9305890;9405671;9418861;9438849;9490638;9497316;9535835;9548756;9582072;9659915;9670022;9792683;9822598;9822605;9829970;9843499;9846874;9988689",
        "class_list": "",
        "function": "CRIF1 deficiency suppresses endothelial cell migration via upregulation of RhoGDI2. Publication Status: Online-Only, [RefSeq, PubMed]; Hyperglycemic Stress Induces Expression, Degradation, and Nuclear Association of Rho GDP Dissociation Inhibitor 2 (RhoGDIbeta) in Pancreatic beta-Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown of RhoGDI2 represses human gastric cancer cell proliferation, invasion and drug resistance via the Rac1/Pak1/LIMK1 pathway., [RefSeq, PubMed]; Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]., [RefSeq]; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:7512369, PubMed:8356058). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133)., [UniProtKB, PubMed, PubMed, PubMed]; RhoGDIbeta inhibition via miR-200c/AUF1/SOX2/miR-137 axis contributed to lncRNA MEG3 downregulation-mediated malignant transformation of human bronchial epithelial cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "prognostic",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5BU79",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005094 Rho GDP-dissociation inhibitor activity;GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0016020 membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0071461 cellular response to redox state;GO:0007266 Rho protein signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:1901164 negative regulation of trophoblast cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 42.1,
        "record_id": "P52566-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P52951-1",
        "uniprot_id": "GBX2_HUMAN",
        "mass": 37348.0,
        "length": 348,
        "protein_name": "Homeobox protein GBX-2",
        "gene_name": "GBX2",
        "organism": "Human",
        "refseq_name": "homeobox protein GBX-2 isoform 1",
        "refseq_ac": "NP_001476",
        "gene_names_uniprotkb": "GBX2",
        "gene_names_refseq": "GBX2",
        "protein_names_uniprotkb": "Homeobox protein GBX-2; Gastrulation and brain-specific homeobox protein 2",
        "protein_names_refseq": "gastrulation and brain-specific homeobox protein 2; homeobox protein GBX-2 isoform 1; homeobox protein GBX-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2637);  (R-HSA-9823739);  (R-HSA-9832991);  (R-HSA-9834899)",
        "pathway_count": 4,
        "publication_count": 14,
        "publication_id_list": "11237011;20074535;27052315;31200836;31758726;32161166;32618493;32938616;33550476;35051231;36222159;7903253;8838315;8895516",
        "class_list": "",
        "function": "CircRERE regulates the expression of GBX2 through miR-1299 and ZC3H13/N(6)-methyladenosine (m(6)A) to promote growth and invasion of hepatocellular carcinoma cells., [RefSeq, PubMed]; GBX2, as a tumor promoter in lung adenocarcinoma, enhances cells viability, invasion and migration by regulating the AKT/ERK signaling pathway., [RefSeq, PubMed]; Gastrulation brain homeobox 2 (GBX2) methylation is associated with Gleason score (GS), pathologic stage (pT), and biochemical recurrence (BCR) in prostate cancer (PCa). Among intraductal carcinoma/cribriform architecture (IDC/C)-negative patients, GBX2 methylation improves prediction of BCR.  Loss of TET2 in prostate cells results in greater GBX2 methylation., [RefSeq, PubMed]; LncRNA FEZF1-AS1 accelerates the migration and invasion of laryngeal squamous cell carcinoma cells through miR-4497 targeting GBX2., [RefSeq, PubMed]; May act as a transcription factor for cell pluripotency and differentiation in the embryo., [UniProtKB]; NCBP3/SNHG6 inhibits GBX2 transcription in a histone modification manner to facilitate the malignant biological behaviour of glioma cells., [RefSeq, PubMed]; The accession number for the cDNA listed for the sequence data at the bottom of page 335 on the left side is incorrect. It should read U31468 instead of U31458., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RPH7;O43833;Q53RX5;Q9Y5Y1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0051960 regulation of nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "P52951-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H1C3-1",
        "uniprot_id": "GL8D2_HUMAN",
        "mass": 40026.0,
        "length": 349,
        "protein_name": "Glycosyltransferase 8 domain-containing protein 2",
        "gene_name": "GLT8D2",
        "organism": "Human",
        "refseq_name": "glycosyltransferase 8 domain-containing protein 2 isoform 1",
        "refseq_ac": "NP_001303896",
        "gene_names_uniprotkb": "GLT8D2; GALA4A; PRO4347",
        "gene_names_refseq": "GLT8D2",
        "protein_names_uniprotkb": "Glycosyltransferase 8 domain-containing protein 2; 2.4.1.-",
        "protein_names_refseq": "glycosyltransferase 8 domain-containing protein 2 isoform 1; glycosyltransferase 8 domain-containing protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:83468)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "11237011;12975309;24173238;25576301;25952508;28228285;29393594;29557506;29789417;30429286;30779550;31154438;31222486;31844290;31848261;32938616;33592498;34374132;36284347;37277853;38840920",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Based on these results, we propose that GLT8D2 is a glycosyltransferase of apoB100 that regulates apoB100 levels in hepatocytes Publication Status: Online-Only, [RefSeq, PubMed]; GLT8D2 is a prognostic biomarker and regulator of immune cell infiltration in gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Glycosyltransferase GLT8D1 and GLT8D2 serve as potential prognostic biomarkers correlated with Tumor Immunity in Gastric Cancer. Erratum:[BMC Med Genomics. 2023 Jun 16;16(1):136. doi: 10.1186/s12920-023-01578-9. PMID: 37328741] Publication Status: Online-Only, [RefSeq, PubMed]; High glycosyltransferase 8 domain containing two protein levels contribute to poor prognosis in urothelial carcinoma., [RefSeq, PubMed]; Role in nonalcoholic fatty liver disease pathogenesis possibly by negatively regulating MTP expression Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 453,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96KA2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q9H1C3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P10071-1",
        "uniprot_id": "GLI3_HUMAN",
        "mass": 169863.0,
        "length": 1580,
        "protein_name": "Transcription activator GLI3",
        "gene_name": "GLI3",
        "organism": "Human",
        "refseq_name": "transcriptional activator GLI3",
        "refseq_ac": "NP_000159",
        "gene_names_uniprotkb": "GLI3",
        "gene_names_refseq": "ACLS; GCPS; GLI3-190; GLI3FL; GLI3; PAP-A; PAPA1; PAPA; PAPB; PHS; PPDIV",
        "protein_names_uniprotkb": "Transcription activator GLI3; GLI3 C-terminally truncated form; GLI3 form of 190 kDa; GLI3 form of 83 kDa; GLI3 full-length protein; GLI3-190; GLI3-83; GLI3FL",
        "protein_names_refseq": "GLI-Kruppel family member GLI3; glioma-associated oncogene family zinc finger 3; oncogene GLI3; transcriptional activator GLI3; zinc finger protein GLI3",
        "tax_id": 9606,
        "disease": "primary bacterial infectious disease (Disease Ontology:DOID:0050338); pre-malignant neoplasm (Disease Ontology:DOID:0060071); preaxial polydactyly type IV (Disease Ontology:DOID:0060985); hypospadias (Disease Ontology:DOID:10892); syndactyly (Disease Ontology:DOID:11193); polydactyly (Disease Ontology:DOID:1148); clubfoot (Disease Ontology:DOID:11836); anodontia (Disease Ontology:DOID:13714); Greig cephalopolysyndactyly syndrome (Disease Ontology:DOID:14761); liver cirrhosis (Disease Ontology:DOID:5082); Pallister-Hall syndrome (Disease Ontology:DOID:9248)",
        "pathway": " (hsa:2737);  (R-HSA-5610785);  (R-HSA-5610787);  (R-HSA-5632684);  (R-HSA-5635851);  (R-HSA-8940973)",
        "pathway_count": 6,
        "publication_count": 189,
        "publication_id_list": "10.1101/2023.09.13.557529;10075717;10375510;10433824;10441342;10441570;10564661;10693759;10966113;11027307;11106645;11237011;11238441;11375483;11545733;11960000;12050670;12068298;12123571;12138125;12192414;12231506;12361967;12391164;12414818;12426310;12435627;12529404;12794692;14528312;14603322;14611647;14723851;14765127;15087129;15115751;15198976;15300262;15930098;16025100;16061793;16099986;16136078;16155214;16229832;16254602;16311594;16339192;16371461;16396903;16421275;16459297;16459298;16493421;16611981;16651542;16705181;16707575;16740475;16751105;16959974;16980583;17027958;17081983;17115028;17200122;17283082;17442700;17553904;17641202;17762891;17764085;17960137;18327258;18455992;18477452;18497258;18827223;18832070;19000668;19196978;19223390;19286674;19305393;19365551;19368795;19371734;19389374;19389811;19533801;19549984;19592253;19622347;19651622;19666503;19684112;19767740;19776033;19801668;19818708;19852954;19877275;19878745;19906846;19948480;19955409;19996169;20014402;20016067;20067783;20154143;20207148;20360384;20395968;20412786;20460306;20487519;20512148;20643644;20686481;20818436;20844016;20865152;20877012;20889716;20956384;2105456;21173110;2118997;21209331;21406692;21695114;21801010;21878643;21921029;22007132;22231273;22391300;22391301;22982193;23186163;23209152;23332756;23719536;23725801;23955340;24072710;24302888;24311597;24339784;24582806;24715725;24845016;24854174;24863049;24917297;24925320;24952464;25865393;26967290;27146893;27797343;28411811;2850480;28514659;28832583;28834231;28965847;29263200;29557506;30620550;31844290;32157095;32938616;33592498;33968037;34087483;34171305;35051231;36010968;36411030;38864382;38968120;39080720;7891679;9182762;9302279;9601642;9874371",
        "class_list": "",
        "function": "A novel missense variant located within the zinc finger domain of the GLI3 gene was identified in a Vietnamese pedigree with index finger polydactyly., [RefSeq, PubMed]; Conclusion of diagnostic odysseys due to inversions disrupting GLI3 and FBN1., [RefSeq, PubMed]; Identification of truncated variants in GLI family zinc finger 3 (GLI3) associated with polydactyly. Publication Status: Online-Only, [RefSeq, PubMed]; Major transcription repressor, which inhibits expression of target genes in the absence of smoothened (SMO) signaling (PubMed:10375510, PubMed:10693759). Generated by proteolytic processing of the full-length GLI3 form in the absence of hedgehog (DHH, IHH or SHH), when SMO transducer is inhibited (PubMed:10375510). Constitutes the major form of GLI3, while the transcription activator form only plays a minor role (PubMed:10375510)., [UniProtKB, PubMed, PubMed]; Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase., [RefSeq, PubMed]; This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor that acts as a key effector of the smoothened signaling pathway, and which plays a role in the development and patterning of various body structures, including the brain and limbs (PubMed:10075717, PubMed:10375510, PubMed:10693759, PubMed:11238441, PubMed:17764085, PubMed:20154143, PubMed:27146893). Specifically binds to the minimal GLI-consensus sequence 5'-GACCACCCA-3' to activate or repress the expression of target genes (PubMed:10075717). Functions both as a transcriptional activator and repressor: the full-length GLI3 form (Transcription activator GLI3) acts as a transcription activator following smoothened activation, while the Transcription repressor GLI3R, which is generated in absence of smoothened, acts as a transcription repressor (PubMed:10375510). The repressor form (GLI3R) constitutes the major form of GLI3 (PubMed:10375510)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Transcription factor, which activates expression of target genes in response to smoothened (SMO) activation (PubMed:10075717, PubMed:27146893). Constitutes a minor form of GLI3, while the transcription repressor form (GLI3R) plays a major role (PubMed:10075717). In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation (PubMed:19389374)., [UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 20,
        "reported_mutagensis": 19,
        "reported_glycation": 0,
        "reported_snv": 99,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 11,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D1W1;O75219;Q17RW4;Q75MT0;Q75MU9;Q9UDT5;Q9UJ39",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium",
        "go_biological_process": "GO:0043585 nose morphogenesis;GO:0046639 negative regulation of alpha-beta T cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 19.4,
        "record_id": "P10071-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NWZ8-1",
        "uniprot_id": "GEMI8_HUMAN",
        "mass": 28637.0,
        "length": 242,
        "protein_name": "Gem-associated protein 8",
        "gene_name": "GEMIN8",
        "organism": "Human",
        "refseq_name": "gem-associated protein 8",
        "refseq_ac": "NP_001035944",
        "gene_names_uniprotkb": "GEMIN8; FAM51A1",
        "gene_names_refseq": "FAM51A1; GEMIN8",
        "protein_names_uniprotkb": "Gem-associated protein 8; Gemin-8; Protein FAM51A1",
        "protein_names_refseq": "family with sequence similarity 51, member A1; gem-associated protein 8; gemin-8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54960);  (R-HSA-191859);  (R-HSA-9754678)",
        "pathway_count": 3,
        "publication_count": 67,
        "publication_id_list": "10531003;10556282;10601333;10725331;10851237;11237011;11333016;11714716;11748230;12065586;12095920;12441251;12776181;16434402;17023415;17178713;18669648;18691976;18984161;19838190;20068231;23481700;25576301;25880248;26375851;27397612;28218747;28228285;28649982;28832583;28834231;28904123;29437277;29508533;29632711;30315122;30410026;30429286;30779550;30833945;31844290;32157095;32350084;32357974;32387766;32502341;32680882;32908316;32938616;32995776;32995777;33080218;33188728;33268501;33479166;33717175;33754639;34315815;34373319;34624207;34932366;35580925;36610391;37938771;38665916;8196654;9845364",
        "class_list": "",
        "function": "Gemin8 has an essential role in the proper structural organization of the SMN complex and the involvement of the heteromeric subunit containing Gemin6, Gemin7, Gemin8, and Unrip in the recruitment of Sm proteins to the snRNP assembly pathway, [RefSeq, PubMed]; Gemin8 is a novel integral component of the SMN complex, [RefSeq, PubMed]; The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP., [UniProtKB, PubMed, PubMed]; The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C4AMC4;Q2LJ66;Q6ZV27",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032797 SMN complex",
        "go_biological_process": "GO:0000387 spliceosomal snRNP assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q9NWZ8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BVM4-1",
        "uniprot_id": "GGACT_HUMAN",
        "mass": 17329.0,
        "length": 153,
        "protein_name": "Gamma-glutamylaminecyclotransferase",
        "gene_name": "GGACT",
        "organism": "Human",
        "refseq_name": "gamma-glutamylaminecyclotransferase",
        "refseq_ac": "NP_001182016",
        "gene_names_uniprotkb": "GGACT; A2LD1",
        "gene_names_refseq": "A2LD1; GGACT",
        "protein_names_uniprotkb": "Gamma-glutamylaminecyclotransferase; 4.3.2.8; AIG2-like domain-containing protein 1; GGACT; Gamma-glutamylamine cyclotransferase",
        "protein_names_refseq": "AIG2-like domain 1; AIG2-like domain-containing protein 1; gamma-glutamylaminecyclotransferase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:87769)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "11237011;20110353;27600516;29557506;29786170",
        "class_list": "",
        "function": "Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine., [UniProtKB, PubMed]; Gamma-glutamylamine cyclotransferase is an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism, [RefSeq, PubMed]; The protein encoded by this gene aids in the proteolytic degradation of crosslinked fibrin by breaking down isodipeptide L-gamma-glutamyl-L-epsilon-lysine, a byproduct of fibrin degradation. The reaction catalyzed by the encoded gamma-glutamylaminecyclotransferase produces 5-oxo-L-proline and a free alkylamine. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Aug 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KTN1;Q9BT41",
        "ec_number_list": "4.3.2.8",
        "go_molecular_function": "GO:0061929 gamma-glutamylaminecyclotransferase activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0042219 modified amino acid catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q9BVM4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14893-1",
        "uniprot_id": "GEMI2_HUMAN",
        "mass": 31585.0,
        "length": 280,
        "protein_name": "Gem-associated protein 2",
        "gene_name": "GEMIN2",
        "organism": "Human",
        "refseq_name": "gem-associated protein 2 isoform gamma",
        "refseq_ac": "NP_001009183",
        "gene_names_uniprotkb": "GEMIN2; SIP1",
        "gene_names_refseq": "GEMIN2; SIP1-delta; SIP1",
        "protein_names_uniprotkb": "Gem-associated protein 2; Component of gems 2; Gemin-2; SMN-interacting protein 1; Survival of motor neuron protein-interacting protein 1",
        "protein_names_refseq": "SMN interacting protein 1-delta; component of gems 2; gem-associated protein 2 isoform gamma; gem-associated protein 2; gemin-2; survival of motor neuron protein interacting protein 1",
        "tax_id": 9606,
        "disease": "spinal muscular atrophy (Disease Ontology:DOID:12377)",
        "pathway": " (hsa:8487);  (R-HSA-191859);  (R-HSA-9754678)",
        "pathway_count": 3,
        "publication_count": 60,
        "publication_id_list": "10500148;10531003;10556282;10601333;10725331;10851237;10909848;11237011;11333016;11714716;11748230;11943600;12065586;12095920;12441251;12776181;16314521;17178713;18669648;18691976;18984161;19413330;19838190;21816274;22607171;23022347;23301498;24275569;24715725;25576301;26092730;26992070;28228285;28489076;28832583;30315122;30484775;31799625;31844290;32680882;32908316;32995776;32995777;33080218;33188728;33268501;33479166;33717175;34171305;34315815;34373319;34624207;36215666;36241641;36610391;37217939;38715801;8196654;9323129;9845364",
        "class_list": "",
        "function": "Interaction between MARK3 (rs11623869), PLCB4 (rs6086746) and GEMIN2 (rs2277458) variants with bone mineral density and serum 25-hidroxivitamin D levels in Mexican Mestizo women. Publication Status: Online-Only, [RefSeq, PubMed]; The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R9W8;Q2M3B3;Q9H4F5;Q9NS77;Q9NS78;Q9NS79",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0016604 nuclear body",
        "go_biological_process": "GO:0000375 RNA splicing, via transesterification reactions;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0000387 spliceosomal snRNP assembly;GO:0000245 spliceosomal complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "O14893-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14908-1",
        "uniprot_id": "GIPC1_HUMAN",
        "mass": 36049.0,
        "length": 333,
        "protein_name": "PDZ domain-containing protein GIPC1",
        "gene_name": "GIPC1",
        "organism": "Human",
        "refseq_name": "PDZ domain-containing protein GIPC1 isoform 1",
        "refseq_ac": "NP_005707",
        "gene_names_uniprotkb": "GIPC1; C19orf3; GIPC; RGS19IP1",
        "gene_names_refseq": "C19orf3; GIPC1; GIPC; GLUT1CBP; Hs.6454; IIP-1; NIP; OPDM2; RGS19IP1; SEMCAP; SYNECTIIN; SYNECTIN; TIP-2",
        "protein_names_uniprotkb": "PDZ domain-containing protein GIPC1; GAIP C-terminus-interacting protein; RGS-GAIP-interacting protein; RGS19-interacting protein 1; Synectin; TIP-2; Tax interaction protein 2",
        "protein_names_refseq": "GAIP C-terminus-interacting protein; GLUT1 C-terminal binding protein; IGF-1 receptor interacting protein 1; PDZ domain-containing protein GIPC1 isoform 1; PDZ domain-containing protein GIPC1; RGS-GAIP-interacting protein; RGS19-interacting protein 1; regulator of G-protein signalling 19 interacting protein 1; tax interaction protein 2",
        "tax_id": 9606,
        "disease": "oculopharyngodistal myopathy 2 (Disease Ontology:DOID:0081298); Parkinson's disease (Disease Ontology:DOID:14330)",
        "pathway": " (hsa:10755);  (R-HSA-190370);  (R-HSA-190373);  (R-HSA-9839389);  (R-HSA-9839397)",
        "pathway_count": 5,
        "publication_count": 88,
        "publication_id_list": "11237011;11294897;11323414;12627230;12958365;1379698;15324302;15863029;16507368;1656221;16597617;16764984;19696444;20117945;21406692;21871877;22424782;23186163;23481700;24275569;24366607;24715725;25502872;25576301;26154972;26375851;26992070;27600516;27846572;27920218;28228285;28832583;28855257;28904123;29242379;29493099;29508533;29557506;29786170;29789417;30315122;30484775;30779550;30833945;31154438;31530632;31844290;31848261;32157095;32161166;32265295;32350084;32357974;32387766;32413282;32488085;32502341;32897882;32938616;33141586;33298915;33592498;33691108;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34405274;35051231;35152460;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37550168;8622701;9139660;9482110;9730987;9770488",
        "class_list": "",
        "function": "GIPC1 CGG Repeat Expansion Is Associated with Movement Disorders., [RefSeq, PubMed]; GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009]., [RefSeq]; Intrafamilial phenotypic heterogeneity in GIPC1-related oculopharyngodistal myopathy type 2: a case report., [RefSeq, PubMed]; May be involved in G protein-linked signaling., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K4I3;A8MZG3;Q9BTC9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0045296 cadherin binding;GO:0017022 myosin binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0016020 membrane",
        "go_biological_process": "GO:0007015 actin filament organization;GO:0007186 G protein-coupled receptor signaling pathway;GO:0006605 protein targeting;GO:0007268 chemical synaptic transmission;GO:0048167 regulation of synaptic plasticity",
        "synthesized_glycan_count": 0,
        "hit_score": 9.1,
        "record_id": "O14908-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75343-1",
        "uniprot_id": "GCYB2_HUMAN",
        "mass": 70368.0,
        "length": 617,
        "protein_name": "Guanylate cyclase soluble subunit beta-2",
        "gene_name": "GUCY1B2",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "GUCY1B2",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Guanylate cyclase soluble subunit beta-2; 4.6.1.2; GCS-beta-2",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (R-HSA-392154);  (R-HSA-445355)",
        "pathway_count": 2,
        "publication_count": 38,
        "publication_id_list": "10777682;10991994;11242081;11457814;11532985;11889009;12048254;14506282;14627618;15377279;156362;17055381;18974361;1930128;19380584;22421042;22778174;23834404;24872348;2526655;25892735;26362469;2764880;27679490;28218747;28741090;29437277;29557506;30484775;34087483;35051231;3780718;8858389;9481611;9598563;9600334;9855623;9889008",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9NZ64",
        "ec_number_list": "4.6.1.2",
        "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0020037 heme binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0008074 guanylate cyclase complex, soluble",
        "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0070482 response to oxygen levels",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "O75343-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P04066-1",
        "uniprot_id": "FUCO_HUMAN",
        "mass": 53689.0,
        "length": 466,
        "protein_name": "Tissue alpha-L-fucosidase",
        "gene_name": "FUCA1",
        "organism": "Human",
        "refseq_name": "tissue alpha-L-fucosidase precursor",
        "refseq_ac": "NP_000138",
        "gene_names_uniprotkb": "FUCA1; Nbla10230",
        "gene_names_refseq": "FUCA1; FUCA",
        "protein_names_uniprotkb": "Tissue alpha-L-fucosidase; 3.2.1.51; Alpha-L-fucosidase 1; Alpha-L-fucosidase I; Alpha-L-fucoside fucohydrolase 1",
        "protein_names_refseq": "I+/--L-fucosidase 1; a-L-fucosidase 1; alpha-L-fucosidase I; alpha-L-fucoside fucohydrolase 1; fucosidase, alpha-L- 1, tissue; tissue alpha-L-fucosidase precursor; tissue alpha-L-fucosidase; tissue fucosidase",
        "tax_id": 9606,
        "disease": "fucosidosis (Disease Ontology:DOID:14500); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)",
        "pathway": " (hsa:2517);  (R-HSA-6798695);  (R-HSA-975578)",
        "pathway_count": 3,
        "publication_count": 89,
        "publication_id_list": "10.1101/2023.09.13.557529;10094192;10343104;10464296;10814706;10988300;11445554;1214294;12408193;12417412;1281988;12880961;16754854;17175120;17466984;18431515;19159218;21406692;21654843;2174090;22661428;23090970;23481700;23650620;24190977;2642067;26992070;27920218;2803312;28467828;28657654;28832583;28904123;2894306;29242379;29314611;29393594;29557506;29632711;29741879;29789417;2983333;30192525;30573663;31844290;32125861;32157095;32350084;32357974;32387766;32502341;32938616;32983136;33141586;33592498;33912179;33936100;33968037;34171305;34357683;34433824;34725712;35051231;35154160;35251023;35254053;35580925;35907402;36206736;36876340;37074911;38665916;38844271;40596516;6096099;7635144;7650030;7815431;7874128;8399358;8401503;8504303;8524845;8692836;8808595;9478973;9741689;9762612;9949196",
        "class_list": "glycogene;glycosylhydrolase",
        "function": "Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins., [UniProtKB, PubMed]; Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis., [RefSeq, PubMed]; Extended analysis of exome sequencing data reveals a novel homozygous deletion of exons 3 and 4 in FUCA1 gene causing fucosidosis in an Indian family., [RefSeq, PubMed]; Potential predictive value of immune-related genes FUCA1 and NCKAP1L for osteosarcoma metastasis., [RefSeq, PubMed]; The long-awaited structure of human fucosidase FucA1 opens novel avenues for the treatment of fucosidosis., [RefSeq, PubMed]; The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.[provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 632,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 53,
        "disease_count": 5,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RBG3;Q14334;Q14335;Q3LID0;Q8NAC2",
        "ec_number_list": "4.6.1.19;3.2.1.24;1.6.2.2;3.2.1.51;3.5.3.1;1.11.2.2;3.2.1.-;3.2.1.22;3.4.21.4;3.2.1.52;3.2.1.31;3.4.21.37;3.4.21.20;4.6.1.18;3.4.16.5;3.4.16.-;2.4.1.1;3.1.27.-;3.1.6.8;3.1.6.14;3.1.6.12;3.2.1.23;1.1.1.205;3.5.1.26;3.4.21.76;2.7.11.24;1.11.1.27;3.1.1.4;2.3.1.23;3.1.6.4;2.7.10.2;3.6.1.-;2.3.3.8;3.4.14.1;3.6.4.6;3.2.1.17;2.7.11.13;6.3.4.21;1.8.4.-;5.3.4.1;3.4.19.9;1.6.5.5;3.1.3.16;5.3.99.3;3.5.4.4;3.4.14.2;3.5.3.15",
        "go_molecular_function": "GO:0004560 alpha-L-fucosidase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0005764 lysosome",
        "go_biological_process": "GO:0019377 glycolipid catabolic process;GO:0016139 glycoside catabolic process;GO:0006004 fucose metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 14.8,
        "record_id": "P04066-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0CG01-1",
        "uniprot_id": "GKN3_HUMAN",
        "mass": 20221.0,
        "length": 181,
        "protein_name": "Gastrokine-3",
        "gene_name": "GKN3P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "GKN3P",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Gastrokine-3",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "20138039",
        "class_list": "",
        "function": "May inhibit gastric epithelial cell proliferation., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0042127 regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "P0CG01-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0CL82-1",
        "uniprot_id": "GG12I_HUMAN",
        "mass": 12978.0,
        "length": 117,
        "protein_name": "G antigen 12I",
        "gene_name": "GAGE12I",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "GAGE12I",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "G antigen 12I; GAGE-12I",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100008586);  (hsa:2579);  (hsa:26748);  (hsa:645073)",
        "pathway_count": 4,
        "publication_count": 2,
        "publication_id_list": "18179644;20546897",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q66I50",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "P0CL82-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P22083-1",
        "uniprot_id": "FUT4_HUMAN",
        "mass": 59084.0,
        "length": 530,
        "protein_name": "Alpha-(1,3)-fucosyltransferase 4",
        "gene_name": "FUT4",
        "organism": "Human",
        "refseq_name": "alpha-(1,3)-fucosyltransferase 4",
        "refseq_ac": "NP_002024",
        "gene_names_uniprotkb": "FUT4; ELFT; FCT3A",
        "gene_names_refseq": "CD15; ELFT; FCT3A; FUC-TIV; FUT4; FUTIV; LeX; SSEA-1",
        "protein_names_uniprotkb": "Alpha-(1,3)-fucosyltransferase 4; 2.4.1.152; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase; ELAM-1 ligand fucosyltransferase; Fuc-TIV; FucT-IV; Fucosyltransferase 4; Fucosyltransferase IV; Galactoside 3-L-fucosyltransferase",
        "protein_names_refseq": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase; ELAM ligand fucosyltransferase; ELAM-1 ligand fucosyltransferase; Lewis X; alpha (1,3) fucosyltransferase, myeloid-specific; alpha-(1,3)-fucosyltransferase 4; fucT-IV; fucosyltransferase IV; galactoside 3-L-fucosyltransferase; stage-specific embryonic antigen 1",
        "tax_id": 9606,
        "disease": "candidiasis (Disease Ontology:DOID:1508)",
        "pathway": " (hsa:2526);  (R-HSA-9037629)",
        "pathway_count": 2,
        "publication_count": 49,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10206952;10212226;11278338;12107078;12222957;12678917;14688233;15158662;1520296;1702034;17123352;1716630;1718983;1740457;1977660;23584533;24953560;25576301;25813380;25892735;28228285;28832583;29314611;29593094;29769354;30429286;31154438;31844290;32350084;32387766;33392160;33717175;34969756;35051231;35251023;36932748;37074623;37963432;38343056;7876235;8207002;8240337;8288606;8333853;9219535;9582303",
        "class_list": "glycogene;glycosyltransferase",
        "function": "CD15 Is a Risk Predictor and a Novel Target in Clear Cell Renal Cell Carcinoma., [RefSeq, PubMed]; CD15(+) Bone Marrow-derived Cells Are Regulators of Immune Response in ARG1-producing Colorectal Cancer Cells., [RefSeq, PubMed]; Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins (PubMed:1702034, PubMed:1716630, PubMed:29593094). Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins (PubMed:1716630, PubMed:29593094). Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis (By similarity). In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (PubMed:11278338, PubMed:1716630)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Does not generate Lewis X antigens., [UniProtKB, PubMed]; ST3GalIV drives SLeX biosynthesis in gastrointestinal cancer cells and associates with cancer cell motility., [RefSeq, PubMed]; Silencing FUT4 Inhibits the Progression of Osteosarcoma through Activation of FOXO1., [RefSeq, PubMed]; The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]., [RefSeq]; X-ray inhibits FUT4-mediated proliferation in A549 cells by downregulating SP1 expression., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 807,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 1,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RMS0",
        "ec_number_list": "2.4.1.-;2.4.1.65;2.4.1.152",
        "go_molecular_function": "GO:0008417 fucosyltransferase activity;GO:0046920 alpha-(1->3)-fucosyltransferase activity;GO:0017083 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0009986 cell surface;GO:0016020 membrane;GO:0032580 Golgi cisterna membrane",
        "go_biological_process": "GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0006688 glycosphingolipid biosynthetic process;GO:0006954 inflammatory response;GO:0005975 carbohydrate metabolic process;GO:0006493 protein O-linked glycosylation",
        "synthesized_glycan_count": 1336,
        "hit_score": 6.0,
        "record_id": "P22083-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P27539-1",
        "uniprot_id": "GDF1_HUMAN",
        "mass": 39475.0,
        "length": 372,
        "protein_name": "Embryonic growth/differentiation factor 1",
        "gene_name": "GDF1",
        "organism": "Human",
        "refseq_name": "embryonic growth/differentiation factor 1 precursor",
        "refseq_ac": "NP_001483",
        "gene_names_uniprotkb": "GDF1",
        "gene_names_refseq": "CHTD6; DORV; DTGA3; GDF1; RAI",
        "protein_names_uniprotkb": "Embryonic growth/differentiation factor 1; GDF-1",
        "protein_names_refseq": "embryonic growth/differentiation factor 1 precursor; embryonic growth/differentiation factor 1",
        "tax_id": 9606,
        "disease": "multiple types of congenital heart defects 6 (Disease Ontology:DOID:0060772); annular pancreas (Disease Ontology:DOID:0060850); right atrial isomerism (Disease Ontology:DOID:0060856); dilated cardiomyopathy (Disease Ontology:DOID:12930); congenital heart disease (Disease Ontology:DOID:1682); liver cirrhosis (Disease Ontology:DOID:5082); double outlet right ventricle (Disease Ontology:DOID:6406); tetralogy of Fallot (Disease Ontology:DOID:6419)",
        "pathway": " (hsa:2657);  (R-HSA-1181150)",
        "pathway_count": 2,
        "publication_count": 38,
        "publication_id_list": "10473623;10822381;10934479;11024047;11294908;11389842;11485994;11779503;11779505;12063393;12592392;14978253;15150278;15350224;15485907;15531507;16260601;17272273;17924340;19114992;2034669;20413652;20694664;21356369;21383881;21532621;28991257;31171573;32144877;32350084;33360347;35351224;38175205;8878477;9288972;9311995;9670020;9702198",
        "class_list": "",
        "function": "A founder truncating variant in GDF1 causes autosomal-recessive right isomerism and associated congenital heart defects in multiplex Arab kindreds., [RefSeq, PubMed]; Arsenic suppresses GDF1 expression via ROS-dependent downregulation of specificity protein 1., [RefSeq, PubMed]; Heterozygous loss-of-function mutations in the human GDF1 gene contribute to cardiac defects ranging from tetralogy of Fallot to transposition of the great arteries., [RefSeq, PubMed]; Homozygous variants in the GDF1 gene related to recurrent right isomerism and complex CHD in two Indian families., [RefSeq, PubMed]; Human colorectal cancer: upregulation of the adaptor protein Rai in TILs leads to cell dysfunction by sustaining GSK-3 activation and PD-1 expression. Publication Status: Online-Only, [RefSeq, PubMed]; May mediate cell differentiation events during embryonic development., [UniProtKB]; Nkx2.5 acts upstream of GDF1 and the genetic variants in GDF1 promoter may confer genetic susceptibility to sporadic CHD potentially by altering its expression. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. The encoded protein is translated from a bicistronic mRNA that also encodes ceramide synthase 1. Mutations in this gene are associated with several congenital cardiovascular malformations. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 8,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43344",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0030509 BMP signaling pathway;GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "P27539-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P32456-1",
        "uniprot_id": "GBP2_HUMAN",
        "mass": 67209.0,
        "length": 591,
        "protein_name": "Guanylate-binding protein 2",
        "gene_name": "GBP2",
        "organism": "Human",
        "refseq_name": "guanylate-binding protein 2",
        "refseq_ac": "NP_004111",
        "gene_names_uniprotkb": "GBP2",
        "gene_names_refseq": "GBP2",
        "protein_names_uniprotkb": "Guanylate-binding protein 2; 3.6.5.-; GBP-2; GTP-binding protein 2; Guanine nucleotide-binding protein 2; HuGBP-2; Interferon-induced guanylate-binding protein 2",
        "protein_names_refseq": "GTP-binding protein 2; guanine nucleotide-binding protein 2; guanylate binding protein 2, interferon-inducible; guanylate-binding protein 2; interferon-induced guanylate-binding protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2634);  (R-HSA-877300);  (R-HSA-909733);  (R-HSA-9948001);  (R-HSA-9953170);  (R-HSA-9956593)",
        "pathway_count": 6,
        "publication_count": 185,
        "publication_id_list": "10067896;10395669;10542297;10982844;10986460;11092454;11337497;11377645;11404376;11585831;11687658;11972023;12029096;12040185;12438563;12446674;12447867;12766484;12842042;12915721;1396683;14586410;14722222;14769151;15047845;1508672;15143187;15312780;15322115;15388922;15449939;15530433;15778442;16009940;16171819;16237089;16467876;16511497;16987978;17125875;1715024;17251292;17266443;1730654;17351669;17969444;18035202;18362138;18575461;18591661;20049711;20130243;20304997;20363976;20643137;21151871;2211721;23061660;23121362;23516580;24366607;24417533;25119034;25371710;25576301;25880248;26154972;27846572;27920218;28218747;28467828;28514659;28593173;28645896;28832583;28904123;29024643;29144452;29177860;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29786170;30315122;30410026;30429286;30485383;30692621;30779550;30833945;31091448;31154438;31216343;31268602;31530632;31844290;31848261;31998317;32032529;32109412;32113509;32157095;32350084;32357974;32488085;32510692;32511913;32574262;32581219;32661006;32758689;32862111;32938616;32983136;33117408;33189161;33193462;33239784;33396578;33592498;33876762;33912179;33936100;33968037;34185709;34357683;34561969;34671164;34916628;35051231;35580925;36284347;36624349;36660930;37558421;37622120;37938771;38636926;39251636;39337476;39394410;40914422;6162102;6548414;688397;7510216;7512561;7514165;7526154;7530745;7537377;7540766;7615558;7617032;7657660;7673114;7690989;7796299;8156998;8176225;8197134;8232552;8315383;8483949;8530158;8550631;8605876;8621447;8631301;8702790;8706832;8830800;9096384;9111318;9121453;9143706;9242679;9334213;9660177;9847332;9861020",
        "class_list": "",
        "function": "GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis., [RefSeq, PubMed]; GBP2 promotes M1 macrophage polarization by activating the notch1 signaling pathway in diabetic nephropathy. Publication Status: Online-Only, [RefSeq, PubMed]; GBP2 promotes clear cell renal cell carcinoma progression through immune infiltration and regulation of PDL1 expression via STAT1 signaling., [RefSeq, PubMed]; Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:31091448). Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). Confers protection to the protozoan pathogen Toxoplasma gondii (By similarity). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins (PubMed:31091448)., [UniProtKB, UniProtKB, PubMed, PubMed]; Observational study of gene-environment interaction. (HuGE Navigator), [RefSeq, PubMed]; The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site. Publication Status: Online-Only, [RefSeq, PubMed]; This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]., [RefSeq]; Weighted gene co-expression network analysis identified GBP2 connected to PPARalpha activity and liver cancer. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6GPH0;Q6IAU2;Q86TB0",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;2.3.2.27;3.6.1.5;2.7.7.84;3.4.21.75;1.8.4.-;1.8.-.-;2.7.10.2;2.7.11.1;3.4.25.1;2.3.2.-;3.6.1.-;2.3.1.-;2.5.1.58;2.5.1.59;3.4.22.57;3.5.4.37;3.6.5.4;2.3.2.24;2.3.2.23;3.1.26.-;6.3.2.n3;3.6.-.-;4.2.-.-;3.1.13.1;3.6.1.15;2.7.-.-;2.7.4.-;3.6.1.6;3.6.1.42;3.1.5.-",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0140678 molecular function inhibitor activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol",
        "go_biological_process": "GO:0006955 immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0051607 defense response to virus;GO:0071222 cellular response to lipopolysaccharide;GO:0034504 protein localization to nucleus",
        "synthesized_glycan_count": 0,
        "hit_score": 18.8,
        "record_id": "P32456-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P33402-1",
        "uniprot_id": "GCYA2_HUMAN",
        "mass": 81750.0,
        "length": 732,
        "protein_name": "Guanylate cyclase soluble subunit alpha-2",
        "gene_name": "GUCY1A2",
        "organism": "Human",
        "refseq_name": "guanylate cyclase soluble subunit alpha-2 isoform 2",
        "refseq_ac": "NP_000846",
        "gene_names_uniprotkb": "GUCY1A2; GUC1A2; GUCSA2",
        "gene_names_refseq": "GC-SA2; GUC1A2; GUCY1A2",
        "protein_names_uniprotkb": "Guanylate cyclase soluble subunit alpha-2; 4.6.1.2; GCS-alpha-2",
        "protein_names_refseq": "GCS-alpha-2; guanylate cyclase 1, soluble, alpha 2; guanylate cyclase soluble subunit alpha-2 isoform 2; guanylate cyclase soluble subunit alpha-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2977);  (R-HSA-392154);  (R-HSA-445355)",
        "pathway_count": 3,
        "publication_count": 51,
        "publication_id_list": "10991994;11242081;11457814;11532985;11889009;12048254;14506282;14627618;15377279;156362;1683630;16959974;17055381;18974361;1930128;19380584;22421042;22778174;23834404;24872348;2526655;25576301;26362469;26992070;2764880;27679490;28741090;29242379;29557506;30379171;31154438;31217245;31848261;32157095;32161166;32387766;32488085;32938616;33298915;33592498;34087483;35051231;37667322;3780718;7673142;8858389;9481611;9598563;9600334;9742221;9855623",
        "class_list": "",
        "function": "Acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunit., [UniProtKB, PubMed]; Alpha subunit of soluble guanylate cyclase (sGC), a central enzyme in nitric oxide (NO) signaling. Functions as the main intracellular receptor for NO. Upon NO binding, catalyzes the conversion of GTP to cyclic GMP (cGMP) and thereby transducing NO signal into a ubiquitous intracellular second messenger., [UniProtKB, PubMed, PubMed]; Circadian gene ARNTL initiates circGUCY1A2 transcription to suppress non-small cell lung cancer progression via miR-200c-3p/PTEN signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L4C4;B7ZLT5",
        "ec_number_list": "4.6.1.2",
        "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0005525 GTP binding;GO:0020037 heme binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0008074 guanylate cyclase complex, soluble",
        "go_biological_process": "GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0070482 response to oxygen levels",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "P33402-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P48060-1",
        "uniprot_id": "GLIP1_HUMAN",
        "mass": 30366.0,
        "length": 266,
        "protein_name": "Glioma pathogenesis-related protein 1",
        "gene_name": "GLIPR1",
        "organism": "Human",
        "refseq_name": "glioma pathogenesis-related protein 1 precursor",
        "refseq_ac": "NP_006842",
        "gene_names_uniprotkb": "GLIPR1; GLIPR; RTVP1",
        "gene_names_refseq": "CRISP7; GLIPR1; GLIPR; RTVP1",
        "protein_names_uniprotkb": "Glioma pathogenesis-related protein 1; GliPR 1; Protein RTVP-1",
        "protein_names_refseq": "GLI pathogenesis-related 1 (glioma); gliPR 1; glioma pathogenesis-related protein 1 precursor; glioma pathogenesis-related protein 1; protein RTVP-1; related to testis-specific, vespid, and pathogenesis proteins 1; testes-specific vespid and pathogenesis protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11010);  (R-HSA-1989781);  (R-HSA-6798695)",
        "pathway_count": 3,
        "publication_count": 62,
        "publication_id_list": "10777541;11237011;11267664;12118000;12177166;12505311;12582161;14871827;15067378;15130092;15635043;16380219;16972786;17825796;18540824;18719978;18848529;19088433;19710929;19934321;20110263;23650620;24196956;26154972;27920218;28218747;28832583;29242379;29393594;29557506;30315122;30410026;30429286;31154438;31844290;31848261;32157095;32350084;32387766;32938616;33298915;33592498;33675864;33742130;33912179;33968037;34357683;35051231;35580925;35760898;36010968;36284347;38368374;7607567;7685352;7892212;8647822;8692836;8973356;9012850;9482873;9748239",
        "class_list": "",
        "function": "Combined therapy of CAR-IL-15/IL-15Ralpha-T cells and GLIPR1 knockdown in cancer cells enhanced anti-tumor effect against gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of the human RTVP-1 gene is down-regulated in human prostate cancer specimens compared with normal human prostate tissue at the mRNA and protein levels., [RefSeq, PubMed]; GLIPR1 and SPARC expression profile reveals a signature associated with prostate Cancer Brain metastasis., [RefSeq, PubMed]; GLIPR1 promotes proliferation, metastasis and 5-fluorouracil resistance in hepatocellular carcinoma by activating the PI3K/PDK1/ROCK1 pathway., [RefSeq, PubMed]; Glioma pathogenesis-related protein 1 performs dual functions in tumor cells. Review article, [RefSeq, PubMed]; This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7YET6;F8VUC2;Q15409;Q969K2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0035577 azurophil granule membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "P48060-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P48728-1",
        "uniprot_id": "GCST_HUMAN",
        "mass": 43946.0,
        "length": 403,
        "protein_name": "Aminomethyltransferase, mitochondrial",
        "gene_name": "AMT",
        "organism": "Human",
        "refseq_name": "aminomethyltransferase, mitochondrial isoform 1 precursor",
        "refseq_ac": "NP_000472",
        "gene_names_uniprotkb": "AMT; GCST",
        "gene_names_refseq": "AMT; GCE2; GCE; GCST; GCVT; NKH",
        "protein_names_uniprotkb": "Aminomethyltransferase, mitochondrial; 2.1.2.10; GCVT; Glycine cleavage system T protein",
        "protein_names_refseq": "aminomethyltransferase, mitochondrial isoform 1 precursor; aminomethyltransferase, mitochondrial; glycine cleavage system T protein; nonketotic hyperglycinemia",
        "tax_id": 9606,
        "disease": "glycine encephalopathy 2 (Disease Ontology:DOID:0061001); glycine encephalopathy (Disease Ontology:DOID:9268)",
        "pathway": " (hsa:275);  (R-HSA-6783984)",
        "pathway_count": 2,
        "publication_count": 21,
        "publication_id_list": "10873393;11237011;11286506;16051266;16263718;1959641;1993704;2025283;26371980;27362913;28244183;31848261;35051231;39894887;6469978;7916605;8005589;8188235;9242632;9600239;9621520",
        "class_list": "",
        "function": "The glycine cleavage system catalyzes the degradation of glycine., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The position and frequency of the breakpoint for CNVs correlated with intron size and presence of Alu elements. Missense mutations, most often recurring, were the most common type of disease-causing mutation in AMT Erratum:[Genet Med. 2018 Sep;20(9):1098. doi: 10.1038/gim.2017.232. PMID: 29300369], [RefSeq, PubMed]; This gene encodes one of four critical components of the glycine cleavage system. Mutations in this gene have been associated with glycine encephalopathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K3I5;B4DE61;B4DJQ0;E9PBG1;Q96IG6",
        "ec_number_list": "2.1.2.10",
        "go_molecular_function": "GO:0008483 transaminase activity;GO:0004047 aminomethyltransferase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005960 glycine cleavage complex",
        "go_biological_process": "GO:0019464 glycine decarboxylation via glycine cleavage system;GO:0006546 glycine catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "P48728-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P50395-1",
        "uniprot_id": "GDIB_HUMAN",
        "mass": 50663.0,
        "length": 445,
        "protein_name": "Rab GDP dissociation inhibitor beta",
        "gene_name": "GDI2",
        "organism": "Human",
        "refseq_name": "rab GDP dissociation inhibitor beta isoform 2",
        "refseq_ac": "NP_001108628",
        "gene_names_uniprotkb": "GDI2; RABGDIB",
        "gene_names_refseq": "GDI2; HEL-S-46e; RABGDIB",
        "protein_names_uniprotkb": "Rab GDP dissociation inhibitor beta; GDI-2; Guanosine diphosphate dissociation inhibitor 2; Rab GDI beta",
        "protein_names_refseq": "GDI-2; epididymis secretory sperm binding protein Li 46e; guanosine diphosphate dissociation inhibitor 2; rab GDI beta; rab GDP dissociation inhibitor beta isoform 2; rab GDP-dissociation inhibitor, beta",
        "tax_id": 9606,
        "disease": "Down syndrome (Disease Ontology:DOID:14250); cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:2665);  (R-HSA-6798695);  (R-HSA-8876198)",
        "pathway_count": 3,
        "publication_count": 309,
        "publication_id_list": "10818110;10990452;10996854;11038176;11179213;11237011;11516400;11689439;11703925;11746448;11784320;11809807;11917121;12058051;12221131;12244319;12364329;12427552;12475894;12684051;12944476;12972505;15096524;15138286;1516130;15247254;15388334;15528189;15561770;15692570;15878329;15914536;15944288;15958533;16207721;16373702;16408927;16410077;16497976;16525024;16525121;16571673;16641372;16754960;16880209;16950109;17043139;17132146;17189207;17208202;17239822;17287728;17308301;17322306;17488286;17562788;17574030;17646400;17671165;17678623;18076383;18083107;18094055;18354496;18367545;1845915;18477474;18512783;18559336;18585354;18664496;18669648;18701652;18779367;18804435;1900457;19109890;19345684;19403694;19413330;19490898;19570034;19608861;19620288;19656848;19725050;19729655;19745841;20008558;20068231;20154091;20159109;20159556;20230923;20305638;20308558;20404108;20434987;20592283;20797862;20851765;20937701;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21951725;22013193;22065758;22072793;22171327;22365832;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23186163;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23645161;23650620;23678941;23684622;23713133;23839779;24029068;24275569;24296415;24352655;24366607;24644286;24694596;24714562;24715725;24719330;24891604;24917561;24967941;25074980;25341920;25343031;25418920;25469497;25472813;25502872;25576301;25645385;25648148;25713415;25810538;25860027;25880248;25892735;25925668;26055712;26154972;26177209;26245486;26375851;26434594;26538022;26728094;26925400;26929215;26936971;26992070;27041585;27044746;27090790;27103185;27246931;27329675;27397612;27600516;27846572;27862975;27920218;28063628;28228285;28467828;28510447;28514659;28649982;28832583;28834231;28855257;28904123;29242379;29314611;29317506;29331515;29393594;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30315122;30410026;30524438;30573663;30779550;30833945;31020640;31154438;31217245;31373491;31530632;31844290;31848261;31998317;32119511;32157095;32162841;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33091337;33214551;33298915;33592498;33691108;33717175;33912179;33936100;33968037;34019948;34051575;34078123;34087483;34357683;34433824;34509645;34556814;34561969;34725712;34894398;34932366;35051231;35138101;35154160;35251023;35561310;35580925;36010968;36215666;36284347;37938771;38665916;40914422;7543319;7688123;7911226;8144603;8408203;8522602;8692836;8863739;9020086;9020161;9030515;9136770;9323142;9434952;9590177;9733780",
        "class_list": "",
        "function": "GDI2 is a novel diagnostic and prognostic biomarker in hepatocellular carcinoma., [RefSeq, PubMed]; GDI2 is a target of paclitaxel that affects tumorigenesis of prostate cancer via the p75NTR signaling pathway., [RefSeq, PubMed]; GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]; GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking. Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling., [RefSeq, PubMed]; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43928;Q5SX88;Q9UQM6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0005093 Rab GDP-dissociation inhibitor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005925 focal adhesion",
        "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0007165 signal transduction;GO:0015031 protein transport;GO:0007264 small GTPase-mediated signal transduction;GO:0016192 vesicle-mediated transport",
        "synthesized_glycan_count": 0,
        "hit_score": 31.4,
        "record_id": "P50395-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P56159-1",
        "uniprot_id": "GFRA1_HUMAN",
        "mass": 51456.0,
        "length": 465,
        "protein_name": "GDNF family receptor alpha-1",
        "gene_name": "GFRA1",
        "organism": "Human",
        "refseq_name": "GDNF family receptor alpha-1 isoform b precursor",
        "refseq_ac": "NP_001138925",
        "gene_names_uniprotkb": "GFRA1; GDNFRA; RETL1; TRNR1",
        "gene_names_refseq": "GDNFR-alpha-1; GDNFRA; GDNFR; GFR-ALPHA-1; GFRA1; GFRalpha-1; RET1L; RETL1; RHDA4; TRNR1",
        "protein_names_uniprotkb": "GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1",
        "protein_names_refseq": "GDNF family receptor alpha-1 isoform b precursor; GDNF receptor alpha 1d; GDNF receptor alpha 1e; GPI-linked anchor protein; Glial cell line-derived neurotrophic factor receptor alpha; PI-linked cell-surface accessory protein; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1",
        "tax_id": 9606,
        "disease": "stroke (Disease Ontology:DOID:0051061); Parkinsonism (Disease Ontology:DOID:0080855); Hirschsprung's disease (Disease Ontology:DOID:10487); sciatic neuropathy (Disease Ontology:DOID:11446); renal agenesis (Disease Ontology:DOID:14766); brain ischemia (Disease Ontology:DOID:2316); Churg-Strauss syndrome (Disease Ontology:DOID:3049); polyarteritis nodosa (Disease Ontology:DOID:9810); renal hypodysplasia/aplasia 4 (MONDO:MONDO:0030822)",
        "pathway": " (hsa:2674);  (R-HSA-419037);  (R-HSA-5673001);  (R-HSA-8853659);  (R-HSA-9830674)",
        "pathway_count": 5,
        "publication_count": 120,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10448070;10508167;10829012;10869344;10995764;11000521;11002419;11027663;11090077;11136978;11237011;11237712;11313946;11360177;11390647;11470823;11491658;11546808;11702783;11886862;12032311;12094235;12121613;12242309;12765789;12771945;14506247;14566559;14707138;14759258;14766744;15044950;15286081;15356145;1545823;15546878;15569713;16267048;16627759;16684964;1716764;17998941;18059411;18775330;1898771;19279408;19615748;19920141;20478380;21102635;21372320;21779497;21779505;21993244;22569528;22589270;22750304;23103841;23303910;23333276;23443682;23575685;23584533;24897931;24937142;25219551;25781681;26085527;2809592;28778966;29393594;29557506;29741879;31135801;31535977;31844290;33020172;34019948;34087483;34668628;34737117;35051231;35494241;35832649;36768269;37074911;39085346;6148751;7665556;7809086;7935463;7972015;8052307;8262246;8394845;8493579;8628282;8631863;8637703;8662982;8663426;8665852;8674117;8710374;8939933;9047384;9177201;9192684;9299438;9398268;9407096;9491986;9545641;9600247;9604935;9764818;9883723;9927426",
        "class_list": "",
        "function": "CircGFRA1 facilitates the malignant progression of HER-2-positive breast cancer via acting as a sponge of miR-1228 and enhancing AIFM2 expression., [RefSeq, PubMed]; Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed:10829012, PubMed:31535977). GDNF-binding leads to autophosphorylation and activation of the RET receptor (PubMed:31535977)., [UniProtKB, PubMed, PubMed]; GDNF/GFRA1 signaling contributes to chemo- and radioresistance in glioblastoma. Publication Status: Online-Only, [RefSeq, PubMed]; LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The Role of Promyelocytic Leukemia Zinc Finger (PLZF) and Glial-Derived Neurotrophic Factor Family Receptor Alpha 1 (GFRalpha1) in the Cryopreservation of Spermatogonia Stem Cells. Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 32,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 14,
        "disease_count": 9,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KA21;O15507;O43912",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005178 integrin binding;GO:0005030 neurotrophin receptor activity;GO:0038023 signaling receptor activity;GO:0016167 glial cell-derived neurotrophic factor receptor activity",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0043235 receptor complex",
        "go_biological_process": "GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway;GO:0007166 cell surface receptor signaling pathway;GO:0007399 nervous system development;GO:0016477 cell migration;GO:0031175 neuron projection development",
        "synthesized_glycan_count": 0,
        "hit_score": 14.1,
        "record_id": "P56159-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P61952-1",
        "uniprot_id": "GBG11_HUMAN",
        "mass": 8481.0,
        "length": 73,
        "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11",
        "gene_name": "GNG11",
        "organism": "Human",
        "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 precursor",
        "refseq_ac": "NP_004117",
        "gene_names_uniprotkb": "GNG11; GNGT11",
        "gene_names_refseq": "GNG11; GNGT11; HG3H1",
        "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11",
        "protein_names_refseq": "G protein gamma-11 subunit; guanine nucleotide binding protein (G protein), gamma 11; guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-11 subunit; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 precursor; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11; heterotrimeric guanine nucleotide-binding protein 3H1",
        "tax_id": 9606,
        "disease": "obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:2791);  (R-HSA-1296041);  (R-HSA-163359);  (R-HSA-202040);  (R-HSA-381676);  (R-HSA-392170);  (R-HSA-392451);  (R-HSA-392851);  (R-HSA-400042);  (R-HSA-4086398);  (R-HSA-416476);  (R-HSA-416482);  (R-HSA-418217);  (R-HSA-418555);  (R-HSA-418592);  (R-HSA-418594);  (R-HSA-418597);  (R-HSA-420092);  (R-HSA-428930);  (R-HSA-432040);  (R-HSA-456926);  (R-HSA-500657);  (R-HSA-6814122);  (R-HSA-8964315);  (R-HSA-8964616);  (R-HSA-9009391);  (R-HSA-9634597);  (R-HSA-9660821);  (R-HSA-9856530);  (R-HSA-997272)",
        "pathway_count": 30,
        "publication_count": 461,
        "publication_id_list": "10191087;10215864;10318832;10319328;10322410;10376603;10380924;10391246;10391247;10395542;10427092;10449730;10488343;10496952;10567430;10588714;10634944;10639123;10649434;10698200;10714768;10727532;10749889;10759852;10764742;10777564;10806474;10858654;10861009;10948191;10954748;11007482;11015615;11029009;11029403;11030334;11034202;11043579;11044445;11060443;11071853;11076974;11185956;11196645;11283606;11294240;11313909;11313914;11369763;11563835;11689445;11698416;11742120;11753430;11773440;11773442;11773443;11786497;11825873;11853546;11946536;11968001;11981029;12015605;12034449;12036966;12048194;12058044;12086864;12101119;12106601;12120503;12123608;12167717;12176338;12180353;12180908;12194985;12388769;12401793;12410638;12421825;12431978;12433842;12446735;12471263;12475787;12482967;12496249;12507995;12511868;12515866;12556497;12560222;12588983;12682286;12724311;12729560;12801959;12808053;12860470;12881510;12887923;12938160;12975316;1325798;1333056;1347957;13549488;13680124;1373524;1378832;14514350;14514735;14573771;14592814;14671004;14675202;14701836;14704854;14742685;14764897;14977528;14988243;15033483;15044318;15090535;1510932;1517224;15231873;15245432;15304325;15314172;1534149;15464082;15467163;15471943;15494017;15496458;15539556;15545263;15569269;15569929;15611108;15657067;15699075;15703994;15705661;15705806;15718470;15749160;15765929;15769620;15889144;15951850;15955806;15956360;15980156;15995848;16102047;16120822;16182515;16212421;16212495;16239258;16268778;16274718;16313925;16339447;16352729;16371464;16373322;16407073;16407156;16415903;16418336;1645720;16460020;16580177;16613879;16634148;16636149;16645038;16687412;16702223;16717095;1672265;16754659;16780920;16835357;16880514;16892066;16920709;16923326;16973695;17037979;17092487;17095603;17156409;17168849;17178220;17185339;17306374;17379646;1739432;17424910;17426020;17444618;17525128;17535799;17545310;17684012;17900700;17916740;17921256;18044684;18162464;18202100;18202181;18206197;1825698;18287102;18374420;18412318;18434541;18456304;18488142;1849000;18511455;1851174;18515384;18566127;18577758;18657504;18678926;18710921;18936096;19020623;1905813;19105585;19138696;19144687;19170255;19177143;19212140;19258039;19342380;19342448;19376773;19383790;1939224;19536106;19574955;19715408;19723632;19741198;19851316;19859570;19861722;19876791;19879889;19929708;19931550;20007474;20381629;20439495;20453851;20650261;20655490;20670195;20861220;21036126;21118996;21172430;2163110;21680538;21844907;21851428;21903638;22028449;22031296;22266855;22446104;22480736;22495674;22661716;22941947;23151663;23256519;23416699;23632248;23637185;23863937;23904219;24039841;2417744;24273487;24530924;24687066;2474350;2491850;24962572;2534964;25414122;2553411;2553705;25587652;25659125;25675501;26190834;26308095;26417854;26590425;26987903;27072905;27288742;27392633;2748346;27566546;27797339;2826231;2834384;28380310;2841328;28450397;28502923;28539435;28595943;2871555;29242379;29443750;29602314;29738483;29786170;2991279;30007591;3049610;30833991;3086311;3104109;31205027;3127824;31279028;31399091;3141418;31848261;31983287;32226383;32296767;32497535;32540603;32618402;32639031;32715661;33049737;33592498;33968037;34499618;3899557;4065330;6085243;6192430;6745415;7503232;7510718;7512962;7514139;7526388;7526779;7532011;7535000;7538665;7559455;7567982;7568118;7589426;7589461;7595566;7624799;7641683;7651538;7665596;7678419;7680413;7700244;7750475;7811244;7876172;7902709;7937899;8007951;8015379;8063828;8073283;8099279;8138058;8140421;8144028;8208289;8277227;8290554;8340388;8390245;8404634;8405712;8406495;8514797;8521505;8522976;8527267;8554519;8598224;8617235;8621513;8662784;8664309;8672451;8683474;8700127;8702633;8733591;8778232;8782602;8816443;8830891;8855281;8876252;8910365;8982657;8997178;9073455;9087410;9152406;9153422;9173876;9227644;9263355;9305846;9308960;9369468;9374639;9374640;9389482;9395517;9417641;9488697;9544801;9565625;9616126;9618465;9620797;9651336;9707174;9756892;9760042;9770463;9796816;9829975;9920805;9924018;9990065",
        "class_list": "",
        "function": "Collectively, these results suggest a novel senescence pathway mediated by GNG11 in response to environmental cues., [RefSeq, PubMed]; Expression of GNG11 induced the generation of reactive oxygen species (ROS) and abnormal nuclear morphology in SUSM-1 cells but not in HeLa cells, [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB]; This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P50152",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0003924 GTPase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005834 heterotrimeric G-protein complex",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 46.2,
        "record_id": "P61952-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P62879-1",
        "uniprot_id": "GBB2_HUMAN",
        "mass": 37331.0,
        "length": 340,
        "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2",
        "gene_name": "GNB2",
        "organism": "Human",
        "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2",
        "refseq_ac": "NP_005264",
        "gene_names_uniprotkb": "GNB2",
        "gene_names_refseq": "GNB2; HG2C1; NEDHYDF; SSS4",
        "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; G protein subunit beta-2; Transducin beta chain 2",
        "protein_names_refseq": "G protein, beta-2 subunit; epididymis secretory sperm binding protein; g protein subunit beta-2; guanine nucleotide binding protein (G protein), beta polypeptide 2; guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; heterotrimeric guanine nucleotide-binding protein 2C1; signal-transducing guanine nucleotide-binding regulatory protein beta subunit; transducin beta chain 2",
        "tax_id": 9606,
        "disease": "sick sinus syndrome 4 (MONDO:MONDO:0859173); neurodevelopmental disorder with hypotonia and dysmorphic facies (MONDO:MONDO:0859185)",
        "pathway": " (hsa:2783);  (R-HSA-1296041);  (R-HSA-163359);  (R-HSA-202040);  (R-HSA-381676);  (R-HSA-392170);  (R-HSA-392451);  (R-HSA-392851);  (R-HSA-400042);  (R-HSA-4086398);  (R-HSA-416476);  (R-HSA-416482);  (R-HSA-418217);  (R-HSA-418555);  (R-HSA-418592);  (R-HSA-418594);  (R-HSA-418597);  (R-HSA-420092);  (R-HSA-428930);  (R-HSA-432040);  (R-HSA-456926);  (R-HSA-500657);  (R-HSA-6814122);  (R-HSA-8964315);  (R-HSA-8964616);  (R-HSA-9009391);  (R-HSA-9634597);  (R-HSA-9660821);  (R-HSA-9856530);  (R-HSA-997272)",
        "pathway_count": 30,
        "publication_count": 552,
        "publication_id_list": "10191087;10215864;10318832;10319328;10322410;10376603;10380924;10391246;10391247;10395542;10427092;10449730;10488343;10496952;10567430;10588714;10634944;10639123;10649434;10698200;10714768;10727532;10749889;10759852;10764742;10777564;10806474;10858654;10861009;10948191;10954748;11007482;11015615;11029009;11029403;11030334;11034202;11043579;11044445;11060443;11071853;11076974;11185956;11196645;11237011;11283606;11294240;11313909;11313914;11369763;11563835;11689445;11698416;11742120;11753430;11773440;11773442;11773443;11782012;11786497;11825873;11853546;11946536;11968001;11981029;12015605;12034449;12036966;12048194;12058044;12086864;12101119;12106601;12120503;12123608;12167717;12176338;12180353;12180908;12194985;12388769;12401793;12410638;12421825;12431978;12433842;12446735;12471263;12475787;12482967;12496249;12507995;12511868;12515866;12556497;12560222;12588983;12682286;12724311;12729560;12801959;12808053;12860470;12881510;12887923;12938160;12975316;1325798;1333056;1347957;13549488;13680124;1373524;1378832;14512443;14514350;14514735;14573771;14592814;14671004;14675202;14701836;14704854;14742685;14764897;14977528;14988243;15033483;15044318;15090535;1510932;1517224;15231873;15245432;15304325;15314172;1534149;15464082;15467163;15471943;15494017;15496458;15539556;15545263;15569269;15569929;15611108;15657067;15699075;15703994;15705661;15705806;15718470;15749160;15765929;15769620;15889144;15951850;15955806;15956360;15980156;15995848;16102047;16120822;16182515;16212421;16212495;16239258;16268778;16274718;16313925;16339447;16352729;16371464;16373322;16407073;16407156;16415903;16418336;1645720;16460020;16498633;16580177;16613879;16634148;16636149;16645038;16687412;16702223;16717095;1672265;16754659;16780920;16835357;16880514;16892066;16920709;16923326;16973695;17037979;17074750;17095603;17156409;17168849;17178220;17185339;17306374;17379646;1739432;17424910;17426020;17444618;17525128;17535799;17545310;17684012;17900700;17916740;17921256;18044684;18162464;18202100;18202181;18206197;1825698;18287102;18374420;18412318;18434541;18456304;18488142;1849000;18511455;1851174;18515384;18566127;18577758;18657504;18678926;18710921;18936096;19020623;1905813;19105585;19138696;19144687;19170255;19177143;19212140;19255495;19258039;19342380;19342448;19376773;19383790;1939224;19536106;19574955;19715408;19723632;19741198;19851316;19859570;19861722;19876791;19879889;19929708;19931550;20007474;20068231;20381629;20439495;20453851;20650261;20655490;20670195;20861220;21036126;21118996;21172430;2163110;21680538;21844907;21851428;21903638;22028449;22031296;22266855;22424782;22446104;22480736;22495674;22661716;22898188;22941947;23151663;23256519;23416699;23481700;23632248;23637185;23863937;23904219;24039841;2417744;24273487;24530924;24687066;24714562;24715725;2474350;2491850;24962572;2534964;25414122;25505266;2553411;2553705;25576301;25587652;25645385;25659125;25675501;26154972;26190834;26308095;26375851;26417854;26590425;26900580;26987903;26992070;27072905;27288742;27392633;27397612;27452731;2748346;27566546;27600516;27797339;27862975;27920218;28218747;28219978;28228285;2826231;2834384;2841328;28450397;28502923;28539435;28595943;28649982;2871555;28832583;28834231;28860189;28904123;29242379;29314611;29331515;29443750;29493099;29508533;29557506;29602314;29632711;29738483;29769354;29786170;29789417;2991279;30007591;30315122;30410026;30429286;3049610;30524438;30833991;3086311;31020640;3104109;3108879;3114742;31154438;31205027;31222486;3127824;31279028;31399091;3141418;31530632;31698099;31844290;31848261;31937595;31983287;31998317;32119511;32157095;32161166;32226383;32265295;32296767;32350084;32387766;32497535;32502341;32540603;32618402;32639031;32715661;32897882;32938616;32983136;33049737;33123756;33141586;33214551;33298915;33592498;33691108;33912179;33968037;33971351;33981976;34019948;34087483;34124757;34171305;34183358;34229054;34357683;34499618;34509645;34932366;35051231;35154160;35251023;35318648;35580925;35730811;36010968;36241641;36284347;37938771;38665916;3899557;4065330;40914422;6085243;6192430;6745415;7503232;7510718;7512962;7514139;7526388;7526779;7532011;7535000;7538665;7559455;7567982;7568118;7589426;7589461;7595566;7624799;7641683;7651538;7678419;7680413;7700244;7750475;7811244;7876172;7902709;7937899;8007951;8015379;8063828;8073283;8099279;8138058;8140421;8144028;8208289;8277227;8290554;8340388;8390245;8404634;8405712;8406495;8514797;8521505;8522976;8527267;8554519;8598224;8617235;8621513;8662784;8664309;8672451;8683474;8700127;8702633;8733591;8778232;8782602;8816443;8830891;8855281;8876252;8910365;8982657;8997178;9073455;9087410;9152406;9153422;9173876;9227644;9263355;9305846;9308960;9369468;9374639;9374640;9389482;9395517;9417641;9488697;9544801;9565625;9616126;9618465;9620797;9651336;9707174;9756892;9760042;9770463;9796816;9799793;9829975;9920805;9924018;9990065",
        "class_list": "",
        "function": "A detailed multi-omics analysis of GNB2 gene in human cancers. Publication Status: Online-Only, [RefSeq, PubMed]; A novel somatic mutation in GNB2 provides new insights to the pathogenesis of Sturge-Weber syndrome., [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB, UniProtKB, UniProtKB]; Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KPU1;P11016;P54312",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0044877 protein-containing complex binding;GO:0051020 GTPase binding;GO:0030159 signaling receptor complex adaptor activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion",
        "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 55.5,
        "record_id": "P62879-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P63215-1",
        "uniprot_id": "GBG3_HUMAN",
        "mass": 8305.0,
        "length": 75,
        "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3",
        "gene_name": "GNG3",
        "organism": "Human",
        "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3",
        "refseq_ac": "NP_036334",
        "gene_names_uniprotkb": "GNG3; GNGT3",
        "gene_names_refseq": "GNG3; HG3D",
        "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3",
        "protein_names_refseq": "NBP gamma-3; guanine nucleotide binding protein (G protein), gamma 3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3; guanine nucleotide-binding protein gamma-3 subunit; heterotrimeric guanine nucleotide-binding protein 3D",
        "tax_id": 9606,
        "disease": "obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:2785);  (R-HSA-1296041);  (R-HSA-163359);  (R-HSA-202040);  (R-HSA-381676);  (R-HSA-392170);  (R-HSA-392451);  (R-HSA-392851);  (R-HSA-400042);  (R-HSA-4086398);  (R-HSA-416476);  (R-HSA-416482);  (R-HSA-418217);  (R-HSA-418555);  (R-HSA-418592);  (R-HSA-418594);  (R-HSA-418597);  (R-HSA-420092);  (R-HSA-428930);  (R-HSA-432040);  (R-HSA-456926);  (R-HSA-500657);  (R-HSA-6814122);  (R-HSA-8964315);  (R-HSA-8964616);  (R-HSA-9009391);  (R-HSA-9634597);  (R-HSA-9660821);  (R-HSA-9856530);  (R-HSA-997272)",
        "pathway_count": 30,
        "publication_count": 457,
        "publication_id_list": "10191087;10215864;10318832;10319328;10322410;10376603;10380924;10391246;10391247;10395542;10427092;10449730;10488343;10496952;10567430;10588714;10634944;10639123;10649434;10698200;10714768;10727532;10749889;10759852;10764742;10777564;10806474;10819326;10858654;10861009;10948191;10954748;11007482;11015615;11029009;11029403;11030334;11034202;11043579;11044445;11060443;11071853;11076974;11185956;11196645;11283606;11294240;11313909;11313914;11369763;11563835;11689445;11698416;11742120;11753430;11773440;11773442;11773443;11786497;11825873;11853546;11946536;11968001;11981029;12015605;12034449;12036966;12048194;12058044;12086864;12101119;12106601;12120503;12123608;12167717;12176338;12180353;12180908;12194985;12388769;12401793;12410638;12421825;12431978;12433842;12446735;12471263;12475787;12482967;12496249;12507995;12511868;12515866;12556497;12560222;12588983;12682286;12724311;12729560;12801959;12808053;12860470;12881510;12887923;12938160;12975316;1325798;1333056;1347957;13549488;13680124;1373524;1378832;14514350;14514735;14573771;14592814;14671004;14675202;14701836;14704854;14742685;14764897;14977528;14988243;15033483;15044318;15090535;1510932;1517224;15231873;15245432;15304325;15314172;1534149;15464082;15467163;15471943;15494017;15496458;15539556;15545263;15569269;15569929;15611108;15657067;15699075;15703994;15705661;15705806;15718470;15749160;15765929;15769620;15889144;15951850;15955806;15956360;15980156;15995848;16102047;16120822;16182515;16212421;16212495;16239258;16268778;16274718;16313925;16339447;16352729;16371464;16373322;16407073;16407156;16415903;16418336;1645720;16460020;16580177;16613879;16634148;16636149;16645038;16687412;16702223;16717095;1672265;16754659;16780920;16835357;16880514;16892066;16920709;16923326;16973695;17037979;17095603;17156409;17168849;17178220;17185339;17306374;17379646;1739432;17424910;17426020;17444618;17525128;17535799;17545310;17684012;17900700;17916740;17921256;18044684;18162464;18202100;18202181;18206197;1825698;18287102;18374420;18412318;18434541;18456304;18488142;1849000;18511455;1851174;18515384;18566127;18577758;18657504;18678926;18710921;18936096;19020623;1905813;19105585;19138696;19144687;19170255;19177143;19212140;19258039;19342380;19342448;19376773;19383790;1939224;19536106;19574955;19715408;19723632;19741198;19851316;19859570;19861722;19876791;19879889;19929708;19931550;20007474;20381629;20439495;20453851;20534534;20650261;20655490;20670195;20861220;21036126;21118996;21172430;2163110;21680538;21844907;21851428;21903638;22028449;22031296;22266855;22446104;22480736;22495674;22661716;22941947;23151663;23256519;23326349;23416699;23632248;23637185;23863937;23904219;24039841;2417744;24273487;24530924;24687066;2474350;2491850;24962572;2534964;25414122;2553411;2553705;25587652;25659125;25675501;26190834;26308095;26417854;26590425;26900580;26987903;27072905;27288742;27392633;2748346;27566546;27797339;2826231;2834384;2841328;28450397;28502923;28539435;28595943;2871555;29443750;29602314;29738483;2991279;30007591;3049610;30833991;3086311;3104109;31205027;3127824;31279028;31399091;3141418;31983287;32226383;32296767;32497535;32540603;32618402;32639031;32715661;33049737;34499618;3899557;4065330;6085243;6192430;6745415;7503232;7510718;7512962;7514139;7526388;7526779;7532011;7535000;7538665;7559455;7567982;7568118;7589426;7589461;7595566;7624799;7641683;7651538;7678419;7680413;7700244;7750475;7811244;7876172;7902709;7937899;8007951;8015379;8063828;8073283;8099279;8138058;8140421;8144028;8208289;8277227;8290554;8340388;8390245;8404634;8405712;8406495;8514797;8521505;8522976;8527267;8554519;8598224;8617235;8621513;8662784;8664309;8672451;8683474;8700127;8702633;8733591;8778232;8782602;8816443;8830891;8855281;8876252;8910365;8982657;8997178;9073455;9087410;9152406;9153422;9173876;9227644;9263355;9305846;9308960;9369468;9374639;9374640;9389482;9395517;9417641;9488697;9544801;9565625;9616126;9618465;9620797;9651336;9707174;9756892;9760042;9770463;9796816;9829975;9920805;9924018;9990065",
        "class_list": "",
        "function": "Findings suggest a wide-ranging mechanism by which direct interaction of Gbetagamma with specific chromatin bound transcription factors regulates functional gene networks in response to GPCR activation in cells including the angiotensin II type 1 receptor. Erratum:[PLoS One. 2016 May 4;11(5):e0155198. doi: 10.1371/journal.pone.0155198. PMID: 27144543], [RefSeq, PubMed]; Golgi structure and secretion is regulated by receptor-induced G protein betagamma complex translocation, [RefSeq, PubMed]; Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012]., [RefSeq]; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R4S7;P29798;Q61014",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0003924 GTPase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0044297 cell body;GO:0005834 heterotrimeric G-protein complex",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration",
        "synthesized_glycan_count": 0,
        "hit_score": 45.8,
        "record_id": "P63215-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P78334-1",
        "uniprot_id": "GBRE_HUMAN",
        "mass": 57972.0,
        "length": 506,
        "protein_name": "Gamma-aminobutyric acid receptor subunit epsilon",
        "gene_name": "GABRE",
        "organism": "Human",
        "refseq_name": "gamma-aminobutyric acid receptor subunit epsilon precursor",
        "refseq_ac": "NP_004952",
        "gene_names_uniprotkb": "GABRE",
        "gene_names_refseq": "GABRE",
        "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit epsilon; GABA(A) receptor subunit epsilon; GABAAR subunit epsilon",
        "protein_names_refseq": "GABA(A) receptor subunit epsilon; GABA(A) receptor, epsilon; GABAAR subunit epsilon; gamma-aminobutyric acid (GABA) A receptor, epsilon; gamma-aminobutyric acid receptor subunit epsilon precursor; gamma-aminobutyric acid receptor subunit epsilon; gamma-aminobutyric acid type A receptor epsilon subunit",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2564)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;16412217;24737792;25660468;29299688;29557506;31719049;32588540;32938616;35051231;9039914;9084408;9339354;9882711",
        "class_list": "",
        "function": "Comprehensive Transcriptome Profiling of Cryptic CBFA2T3-GLIS2 Fusion-Positive AML Defines Novel Therapeutic Options: A COG and TARGET Pediatric AML Study., [RefSeq, PubMed]; Data from the present study suggest a marginal role of GABRE rs1139916 in the risk for migraine in women., [RefSeq, PubMed]; Data indicate that GABA(A) receptor subunit epsilon (GABRE) approximately miR-452 approximately miR-224 locus is downregulated and hypermethylated in prostate cancer and is a promising epigenetic candidate biomarker for prostate cancer diagnosis and prognosis., [RefSeq, PubMed]; Epsilon subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:16412217, PubMed:9882711). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). GABAARs containing epsilon subunits also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (PubMed:16412217, PubMed:9882711). GABARs containing epsilon subunit may regulate cardiac function (Probable)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]; Rare variants in the GABAA receptor subunit epsilon identified in patients with a wide spectrum of epileptic phenotypes., [RefSeq, PubMed]; The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008]., [RefSeq]; This study showed that in male groups, the expression of GABRE was generally lower in schizophrenia cases compared to the control., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E7ET93;O15345;O15346;Q6PCD2;Q99520",
        "ec_number_list": "1.8.-.-;1.8.5.1;1.11.1.-;5.6.1.6",
        "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity",
        "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0098794 postsynapse;GO:0034707 chloride channel complex;GO:0032590 dendrite membrane;GO:1902711 GABA-A receptor complex",
        "go_biological_process": "GO:2001226 negative regulation of chloride transport;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "P78334-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q02108-1",
        "uniprot_id": "GCYA1_HUMAN",
        "mass": 77452.0,
        "length": 690,
        "protein_name": "Guanylate cyclase soluble subunit alpha-1",
        "gene_name": "GUCY1A1",
        "organism": "Human",
        "refseq_name": "guanylate cyclase soluble subunit alpha-1 isoform A",
        "refseq_ac": "NP_000847",
        "gene_names_uniprotkb": "GUCY1A1; GUC1A3; GUCSA3; GUCY1A3",
        "gene_names_refseq": "GC-S-alpha-1; GC-SA3; GCS-alpha-3; GUC1A3; GUCA3; GUCSA3; GUCY1A1; GUCY1A3; MYMY6",
        "protein_names_uniprotkb": "Guanylate cyclase soluble subunit alpha-1; 4.6.1.2; GCS-alpha-1; GCS-alpha-3; Guanylate cyclase soluble subunit alpha-3; Soluble guanylate cyclase large subunit",
        "protein_names_refseq": "guanylate cyclase 1, soluble, alpha 3; guanylate cyclase soluble subunit alpha-1 isoform A; guanylate cyclase soluble subunit alpha-1; soluble guanylate cyclase large subunit",
        "tax_id": 9606,
        "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); primary open angle glaucoma (Disease Ontology:DOID:1070); Moyamoya disease (Disease Ontology:DOID:13099)",
        "pathway": " (hsa:2982);  (R-HSA-392154);  (R-HSA-445355)",
        "pathway_count": 3,
        "publication_count": 66,
        "publication_id_list": "10991994;11237011;11242081;11457814;11532985;11889009;12048254;1352257;14506282;14627618;15377279;156362;17055381;18974361;1930128;19380584;22421042;22778174;23505436;23834404;24581742;24669844;24872348;2526655;25892735;26362469;26375851;2764880;27679490;27893789;28741090;29437277;29557506;30410026;31154438;31530632;31844290;31848261;31937595;32357974;32502341;32938616;33141586;33298915;33430449;33571505;33592498;33717175;33912179;33936100;34171305;34185709;34535643;35051231;35494241;35580925;36241641;36941667;3780718;37938771;8858389;9481611;9598563;9600334;9742212;9855623",
        "class_list": "",
        "function": "Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Publication Status: Online-Only, [RefSeq, PubMed]; Biallelic variants in NOS3 and GUCY1A3, the two major genes of the nitric oxide pathway, cause moyamoya cerebral angiopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Higher susceptibility to heme oxidation and lower protein stability of the rare alpha1C517Ybeta1 sGC variant associated with moyamoya syndrome., [RefSeq, PubMed]; Inflammation in the Human Periodontium Induces Downregulation of the alpha1- and beta1-Subunits of the sGC in Cementoclasts. Publication Status: Online-Only, [RefSeq, PubMed]; Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DP19;D6RDW3;O43843;Q8TAH3",
        "ec_number_list": "4.6.1.2",
        "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0005525 GTP binding;GO:0020037 heme binding;GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0008074 guanylate cyclase complex, soluble",
        "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0008015 blood circulation;GO:0007263 nitric oxide mediated signal transduction;GO:0038060 nitric oxide-cGMP-mediated signaling;GO:0098925 retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission",
        "synthesized_glycan_count": 0,
        "hit_score": 6.7,
        "record_id": "Q02108-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q11130-1",
        "uniprot_id": "FUT7_HUMAN",
        "mass": 39239.0,
        "length": 342,
        "protein_name": "Alpha-(1,3)-fucosyltransferase 7",
        "gene_name": "FUT7",
        "organism": "Human",
        "refseq_name": "alpha-(1,3)-fucosyltransferase 7",
        "refseq_ac": "NP_004470",
        "gene_names_uniprotkb": "FUT7",
        "gene_names_refseq": "FUT7; FucT-VII",
        "protein_names_uniprotkb": "Alpha-(1,3)-fucosyltransferase 7; 2.4.1.-; Fuc-TVII; FucT-VII; Fucosyltransferase 7; Fucosyltransferase VII; Galactoside 3-L-fucosyltransferase; Selectin ligand synthase",
        "protein_names_refseq": "alpha-(1,3)-fucosyltransferase 7; fuc-TVII; fucosyltransferase 7 (alpha (1,3) fucosyltransferase); fucosyltransferase VII; galactoside 3-L-fucosyltransferase; selectin-ligand synthase",
        "tax_id": 9606,
        "disease": "candidiasis (Disease Ontology:DOID:1508)",
        "pathway": " (hsa:2529);  (R-HSA-9037629)",
        "pathway_count": 2,
        "publication_count": 55,
        "publication_id_list": "10200296;10206952;10212226;10386892;11404359;11425803;12107078;12222957;12678917;14688233;15081893;15158662;1520296;15632313;15926890;1702034;17123352;1716630;17229154;1740457;18402946;18553500;19455659;1977660;24953560;27846572;28514659;28832583;29138114;29242379;29593094;31154438;34134578;34973535;35051231;36463240;36898609;7876235;8051184;8182079;8207002;8240337;8288606;8333853;8666674;8752218;9219535;9299472;9405391;9461592;9473504;9499379;9582303;9834120;9858509",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Activation of alpha7 nicotinic acetylcholine receptors attenuates monocyte-endothelial adhesion through FUT7 inhibition., [RefSeq, PubMed]; Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein or a glycolipid-linked sialopolylactosamines chain through an alpha-1,3 glycosidic linkage and participates in the final fucosylation step in the biosynthesis of the sialyl Lewis X (sLe(x)), a carbohydrate involved in cell and matrix adhesion during leukocyte trafficking and fertilization (PubMed:11404359, PubMed:15632313, PubMed:15926890, PubMed:18402946, PubMed:18553500, PubMed:29593094, PubMed:8207002, PubMed:8666674, PubMed:8752218, PubMed:9299472, PubMed:9405391, PubMed:9461592, PubMed:9473504, PubMed:9499379). In vitro, also synthesizes sialyl-dimeric-Lex structures, from VIM-2 structures and both di-fucosylated and trifucosylated structures from mono-fucosylated precursors (PubMed:9499379). However does not catalyze alpha 1-3 fucosylation when an internal alpha 1-3 fucosylation is present in polylactosamine chain and the fucosylation rate of the internal GlcNAc residues is reduced once fucose has been added to the distal GlcNAc (PubMed:9473504, PubMed:9499379). Also catalyzes the transfer of a fucose from GDP-beta-fucose to the 6-sulfated a(2,3)sialylated substrate to produce 6-sulfo sLex mediating significant L-selectin-dependent cell adhesion (PubMed:10200296, PubMed:8752218). Through sialyl-Lewis(x) biosynthesis, can control SELE- and SELP-mediated cell adhesion with leukocytes and allows leukocytes tethering and rolling along the endothelial tissue thereby enabling the leukocytes to accumulate at a site of inflammation (PubMed:10386892, PubMed:29138114, PubMed:8666674, PubMed:9473504, PubMed:9834120). May enhance embryo implantation through sialyl Lewis X (sLeX)-mediated adhesion of embryo cells to endometrium (PubMed:18402946, PubMed:18553500). May affect insulin signaling by up-regulating the phosphorylation and expression of some signaling molecules involved in the insulin-signaling pathway through SLe(x) which is present on the glycans of the INSRR alpha subunit (PubMed:17229154)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Identification of FUT7 hypomethylation as the blood biomarker in the prediction of early-stage lung cancer., [RefSeq, PubMed]; Integrated analysis reveals the participation of IL4I1, ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by targeting glycolysis., [RefSeq, PubMed]; Novel blood-based FUT7 DNA methylation is associated with lung cancer: especially for lung squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X antigens. The encoded protein can direct the synthesis of the E-selectin-binding sialyl-Lewis X moiety. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 474,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R7U7;Q6DK54",
        "ec_number_list": "2.4.1.-;2.4.1.65;2.4.1.152",
        "go_molecular_function": "GO:0008417 fucosyltransferase activity;GO:0046920 alpha-(1->3)-fucosyltransferase activity;GO:0017083 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0032580 Golgi cisterna membrane;GO:0005802 trans-Golgi network",
        "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:1903238 positive regulation of leukocyte tethering or rolling;GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell;GO:0006954 inflammatory response;GO:0045785 positive regulation of cell adhesion",
        "synthesized_glycan_count": 556,
        "hit_score": 5.8,
        "record_id": "Q11130-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14410-1",
        "uniprot_id": "GLPK2_HUMAN",
        "mass": 60594.0,
        "length": 553,
        "protein_name": "Glycerol kinase 2",
        "gene_name": "GK2",
        "organism": "Human",
        "refseq_name": "glycerol kinase 2",
        "refseq_ac": "NP_149991",
        "gene_names_uniprotkb": "GK2; GKP2; GKTA",
        "gene_names_refseq": "GK2; GKP2; GKTA",
        "protein_names_uniprotkb": "Glycerol kinase 2; 2.7.1.30; ATP:glycerol 3-phosphotransferase 2; GK 2; Glycerokinase 2; Glycerol kinase, testis specific 2",
        "protein_names_refseq": "ATP:glycerol 3-phosphotransferase 2; glycerokinase 2; glycerol kinase 2; glycerol kinase pseudogene 2; glycerol kinase testis specific 2; testis tissue sperm-binding protein Li 77m",
        "tax_id": 9606,
        "disease": "glycerol kinase deficiency (Disease Ontology:DOID:0060363)",
        "pathway": " (hsa:2712);  (R-HSA-75109)",
        "pathway_count": 2,
        "publication_count": 28,
        "publication_id_list": "11481335;11672446;12618427;12824082;14521909;14970677;15845384;17158099;18238778;18491316;18694939;18718904;19336658;20643956;20877624;23481700;25838202;26289852;28514659;28852571;28904123;29242379;29393594;29769354;31217245;34357683;35051231;7987308",
        "class_list": "",
        "function": "Analysis of LGALS3, PHB2, MUC1, and GK2 expression with CA15-3 in early-stage breast cancer, [RefSeq, PubMed]; Key enzyme in the regulation of glycerol uptake and metabolism. Essential for male fertility and sperm mitochondrial sheath formation (By similarity). Required for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during spermatogenesis (By similarity). Can induce mitochondrial clustering through interactions with PLD6 and up-regulation of phosphatidic acid synthesis in the mitochondria (PubMed:28852571)., [UniProtKB, UniProtKB, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K876;Q6PD73;Q86XV8",
        "ec_number_list": "2.7.1.30",
        "go_molecular_function": "GO:0004370 glycerol kinase activity;GO:0005524 ATP binding",
        "go_cellular_component": "GO:0097226 sperm mitochondrial sheath;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0070062 extracellular exosome;GO:0097225 sperm midpiece",
        "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0046167 glycerol-3-phosphate biosynthetic process;GO:0006641 triglyceride metabolic process;GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q14410-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q3B7J2-1",
        "uniprot_id": "GFOD2_HUMAN",
        "mass": 42255.0,
        "length": 385,
        "protein_name": "Glucose-fructose oxidoreductase domain-containing protein 2",
        "gene_name": "GFOD2",
        "organism": "Human",
        "refseq_name": "glucose-fructose oxidoreductase domain-containing protein 2 isoform 2 precursor",
        "refseq_ac": "NP_001230579",
        "gene_names_uniprotkb": "GFOD2; PRO34691",
        "gene_names_refseq": "GFOD2",
        "protein_names_uniprotkb": "Glucose-fructose oxidoreductase domain-containing protein 2; 1.-.-.-",
        "protein_names_refseq": "glucose-fructose oxidoreductase domain containing 2; glucose-fructose oxidoreductase domain-containing protein 2 isoform 2 precursor; glucose-fructose oxidoreductase domain-containing protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81577)",
        "pathway_count": 1,
        "publication_count": 32,
        "publication_id_list": "11237011;12975309;17081983;23481700;24064143;24714562;24715725;25418920;25645385;26992070;28218747;28228285;28514659;28904123;29393594;29437277;29557506;29605689;30315122;31844290;32161166;32357974;32387766;32488085;32938616;33298915;33936100;33968037;34211107;34509645;35580925;39894887",
        "class_list": "",
        "function": "Promotes matrix assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Variation in the GFOD2 gene contributes to the genetic basis for a differential response to a cholesterol- or lipid-lowering diet., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q69YL9;Q6UXX6;Q7L648;Q8TE86;Q9BQ07;R4GNG5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000166 nucleotide binding;GO:0016491 oxidoreductase activity",
        "go_cellular_component": "GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0030198 extracellular matrix organization",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q3B7J2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5U4N7-1",
        "uniprot_id": "GDAS1_HUMAN",
        "mass": 28211.0,
        "length": 250,
        "protein_name": "Protein GDF5-AS1, mitochondrial",
        "gene_name": "GDF5-AS1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "GDF5-AS1; GDF5OS",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Protein GDF5-AS1, mitochondrial; GDF5 antisense RNA 1; Growth/differentiation factor 5 opposite strand transcript protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 3,
        "publication_id_list": "28904123;29557506;35580925",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6PVI8",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q5U4N7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5VSY0-1",
        "uniprot_id": "GKAP1_HUMAN",
        "mass": 42078.0,
        "length": 366,
        "protein_name": "G kinase-anchoring protein 1",
        "gene_name": "GKAP1",
        "organism": "Human",
        "refseq_name": "G kinase-anchoring protein 1 isoform b",
        "refseq_ac": "NP_001129425",
        "gene_names_uniprotkb": "GKAP1; FKSG21; GKAP42",
        "gene_names_refseq": "FKSG21; GKAP1; GKAP42",
        "protein_names_uniprotkb": "G kinase-anchoring protein 1; cGMP-dependent protein kinase-anchoring protein of 42 kDa",
        "protein_names_refseq": "G kinase-anchoring protein 1 isoform b; cGMP-dependent protein kinase anchoring protein 42kDa; cGMP-dependent protein kinase-anchoring protein of 42 kDa; protein kinase anchoring protein GKAP42",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80318)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "10671526;11237011;16015647;18077418;18669648;20068231;21740066;23186163;25576301;28834231;30429286;32157095;32938616;33968037",
        "class_list": "",
        "function": "Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation., [UniProtKB, UniProtKB]; This gene encodes a protein that is highly similar to the mouse cGMP-dependent protein kinase anchoring protein 42kDa. The mouse protein has been found to localize with the Golgi and recruit cGMP-dependent protein kinase I alpha to the Golgi in mouse testes. It is thought to play a role in germ cell development. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]., [RefSeq]; This paper describes the protein interaction, expression, localization and function of a highly similar gene in mouse., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96LI0;Q9BYI1;Q9BYI2;Q9H225",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007168 receptor guanylyl cyclase signaling pathway;GO:0046628 positive regulation of insulin receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q5VSY0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5VV16-1",
        "uniprot_id": "FX4L5_HUMAN",
        "mass": 45780.0,
        "length": 416,
        "protein_name": "Forkhead box protein D4-like 5",
        "gene_name": "FOXD4L5",
        "organism": "Human",
        "refseq_name": "forkhead box protein D4-like 5",
        "refseq_ac": "NP_001119806",
        "gene_names_uniprotkb": "FOXD4L5",
        "gene_names_refseq": "FOXD4L5; bA15J10.2",
        "protein_names_uniprotkb": "Forkhead box protein D4-like 5; FOXD4-like 5",
        "protein_names_refseq": "FOXD4-like 5; forkhead box protein D4-like 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:653427)",
        "pathway_count": 1,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0009653 anatomical structure morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "Q5VV16-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7L5L3-2",
        "uniprot_id": "GDPD3_HUMAN",
        "mass": 36596.0,
        "length": 318,
        "protein_name": "Lysophospholipase D GDPD3",
        "gene_name": "GDPD3",
        "organism": "Human",
        "refseq_name": "lysophospholipase D GDPD3",
        "refseq_ac": "NP_077283",
        "gene_names_uniprotkb": "GDPD3; GDE7",
        "gene_names_refseq": "GDE7; GDPD3",
        "protein_names_uniprotkb": "Lysophospholipase D GDPD3; 3.1.4.-; Glycerophosphodiester phosphodiesterase 7; Glycerophosphodiester phosphodiesterase domain-containing protein 3",
        "protein_names_refseq": "glycerophosphodiester phosphodiesterase 7; glycerophosphodiester phosphodiesterase domain-containing protein 3; lysophospholipase D GDPD3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79153);  (R-HSA-6814848)",
        "pathway_count": 2,
        "publication_count": 19,
        "publication_id_list": "10760272;12514188;12576545;15044461;15788404;16472945;16799181;17015841;18086666;18667693;25528375;27637550;29557506;30379171;32430316;32983136;34673020;37193762;37938771",
        "class_list": "",
        "function": "Development of a selective fluorescence-based enzyme assay for glycerophosphodiesterase family members GDE4 and GDE7., [RefSeq, PubMed]; GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator. Publication Status: Online-Only, [RefSeq, PubMed]; Human GDPD3 overexpression promotes liver steatosis by increasing lysophosphatidic acid production and fatty acid uptake., [RefSeq, PubMed]; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:27637550). Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylcholine (lyso-PC) and N-acylethanolamine lysophospholipids (PubMed:27637550). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine., [UniProtKB, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9H652",
        "ec_number_list": "3.1.2.2;3.1.1.4;3.1.1.5;3.1.2.22;3.1.2.-;3.1.1.32;3.1.1.3;3.1.1.13;3.1.1.6;3.1.4.39;3.1.4.4;3.1.4.54;3.1.1.-;3.1.4.-;3.5.1.1;3.1.1.47;2.3.1.-;3.1.4.44",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008081 phosphoric diester hydrolase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm;GO:0070062 extracellular exosome;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0034638 phosphatidylcholine catabolic process;GO:0070291 N-acylethanolamine metabolic process;GO:0046475 glycerophospholipid catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q7L5L3-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IVK1-1",
        "uniprot_id": "GLCM1_HUMAN",
        "mass": 5018.0,
        "length": 47,
        "protein_name": "Putative glycosylation-dependent cell adhesion molecule 1",
        "gene_name": "GLYCAM1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "GLYCAM1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative glycosylation-dependent cell adhesion molecule 1; GlyCAM-1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (R-HSA-198933)",
        "pathway_count": 1,
        "publication_count": 79,
        "publication_id_list": "10499918;10746781;11265639;11489943;11513152;11556966;11807247;11857637;11858820;11861603;11955593;11955595;11955599;12057858;12213321;12483297;12588680;14719373;14970179;15034010;15136729;15155468;15187158;15304001;15534202;15541655;15580655;15607800;15778510;15781451;15800062;15851719;15864273;16014749;16091383;16129954;16339513;16380601;16551255;16737824;16754721;16893496;16904340;16928187;17045824;17057721;17237375;17337780;18031695;18037897;18055229;18209062;18234675;18593354;19149696;19359216;19592130;20730098;21241660;21800138;21841309;21877119;22396535;23695528;23929856;24305946;24715725;25703557;25716998;26284469;26300885;7531291;7542404;8178173;8995416;9285412;9314561;9700512;9730896",
        "class_list": "glycogene",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IUA8",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 8.0,
        "record_id": "Q8IVK1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N7Z2-1",
        "uniprot_id": "GG6L1_HUMAN",
        "mass": 83069.0,
        "length": 668,
        "protein_name": "Golgin subfamily A member 6-like protein 1",
        "gene_name": "GOLGA6L1",
        "organism": "Human",
        "refseq_name": "golgin subfamily A member 6-like protein 1",
        "refseq_ac": "NP_001001413",
        "gene_names_uniprotkb": "GOLGA6L1",
        "gene_names_refseq": "GOLGA6L1",
        "protein_names_uniprotkb": "Golgin subfamily A member 6-like protein 1",
        "protein_names_refseq": "golgi autoantigen, golgin subfamily a, 6-like 1; golgin subfamily A member 6-like protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283767)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "29242379;30620550",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A087WU96",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q8N7Z2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N9F7-1",
        "uniprot_id": "GDPD1_HUMAN",
        "mass": 36167.0,
        "length": 314,
        "protein_name": "Lysophospholipase D GDPD1",
        "gene_name": "GDPD1",
        "organism": "Human",
        "refseq_name": "lysophospholipase D GDPD1 isoform 3",
        "refseq_ac": "NP_001159465",
        "gene_names_uniprotkb": "GDPD1; GDE4",
        "gene_names_refseq": "GDE4; GDPD1",
        "protein_names_uniprotkb": "Lysophospholipase D GDPD1; 3.1.4.-; Glycerophosphodiester phosphodiesterase 4; Glycerophosphodiester phosphodiesterase domain-containing protein 1",
        "protein_names_refseq": "glycerophosphodiester phosphodiesterase 4; glycerophosphodiester phosphodiesterase domain-containing protein 1; lysophospholipase D GDPD1 isoform 3; lysophospholipase D GDPD1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:284161);  (R-HSA-6814848)",
        "pathway_count": 2,
        "publication_count": 30,
        "publication_id_list": "10.1101/2023.09.13.557529;10760272;11237011;12514188;12576545;14612981;15044461;15788404;16147865;16472945;16799181;17015841;18086666;18667693;18991142;25418920;25528375;25576336;25596343;27637550;28832583;30779550;31844290;32157095;32387766;33022222;34171305;34673020;35051231;35494241",
        "class_list": "",
        "function": "3-D model provides the structural information; subcellular localization is in the cytoplasm; over-expression of GDE4 did not induce neurite formation or change cell morphology, [RefSeq, PubMed]; A novel splice variant of the gene is mainly expressed in human ovary and small intestine., [RefSeq, PubMed]; Development of a selective fluorescence-based enzyme assay for glycerophosphodiesterase family members GDE4 and GDE7., [RefSeq, PubMed]; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:25596343, PubMed:27637550). Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC) (PubMed:25596343, PubMed:27637550). May be involved in bioactive N-acylethanolamine biosynthesis from both N-acyl-lysoplasmenylethanolamin (N-acyl-lysoPlsEt) and N-acyl-lysophosphatidylethanolamin (N-acyl-lysoPE) (PubMed:25596343, PubMed:27637550). In addition, hydrolyzes glycerophospho-N-acylethanolamine to N-acylethanolamine (PubMed:27637550). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Structural Variants Create New Topological-Associated Domains and Ectopic Retinal Enhancer-Gene Contact in Dominant Retinitis Pigmentosa., [RefSeq, PubMed]; This gene encodes a member of the glycerophosphodiester phosphodiesterase family of enzymes that catalyze the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol. The encoded protein is localized to the cytoplasm and concentrates near the perinuclear region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8W735;Q56VR1;Q8N4E3",
        "ec_number_list": "3.1.4.39;3.1.4.4;3.1.4.54;3.1.4.-;3.1.4.44",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008081 phosphoric diester hydrolase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0070291 N-acylethanolamine metabolic process;GO:0046475 glycerophospholipid catabolic process;GO:0006629 lipid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q8N9F7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N9W4-3",
        "uniprot_id": "GG6L2_HUMAN",
        "mass": 100610.0,
        "length": 909,
        "protein_name": "Golgin subfamily A member 6-like protein 2",
        "gene_name": "GOLGA6L2",
        "organism": "Human",
        "refseq_name": "golgin subfamily A member 6-like protein 2",
        "refseq_ac": "NP_001291317",
        "gene_names_uniprotkb": "GOLGA6L2",
        "gene_names_refseq": "CT105; GOLGA6L2",
        "protein_names_uniprotkb": "Golgin subfamily A member 6-like protein 2",
        "protein_names_refseq": "cancer/testis antigen 105; golgi autoantigen, golgin subfamily a, 6-like 2; golgin subfamily A member 6-like protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283685)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "30620550",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L301;H3BMJ4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q8N9W4-3",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NHV1-1",
        "uniprot_id": "GIMA7_HUMAN",
        "mass": 34509.0,
        "length": 300,
        "protein_name": "GTPase IMAP family member 7",
        "gene_name": "GIMAP7",
        "organism": "Human",
        "refseq_name": "GTPase IMAP family member 7",
        "refseq_ac": "NP_694968",
        "gene_names_uniprotkb": "GIMAP7; IAN7",
        "gene_names_refseq": "GIMAP7; IAN7; hIAN7",
        "protein_names_uniprotkb": "GTPase IMAP family member 7; IAN-7; Immunity-associated nucleotide 7 protein",
        "protein_names_refseq": "GTPase IMAP family member 7; IAN-7; immune associated nucleotide; immune-associated nucleotide-binding protein 7; immunity-associated nucleotide 7 protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:168537)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "15474311;20237496;23454188;26154972;27846572;28832583;29351928;29493099;29557506;29786170;30429286;31154438;31748878;31844290;31848261;32350084;32488085;32983136;34087483;35051231;35154160;35580925;36581994;40914422",
        "class_list": "",
        "function": "GIMAP7 induces oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome by inhibiting sonic hedgehog signalling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of GIMAP7 and Rabl3 as Putative Biomarkers for Oral Squamous Cell Carcinoma Through Comparative Proteomic Approach., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The crystal structure of GTP-bound GIMAP7 shows a homodimer assembled via the G domains, with the helical extensions protruding in opposite directions., [RefSeq, PubMed]; The dimer has GTPase activity; the active site contains residues from both subunits., [UniProtKB, PubMed]; This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet",
        "go_biological_process": "GO:0046039 GTP metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q8NHV1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TF64-1",
        "uniprot_id": "GIPC3_HUMAN",
        "mass": 33982.0,
        "length": 312,
        "protein_name": "PDZ domain-containing protein GIPC3",
        "gene_name": "GIPC3",
        "organism": "Human",
        "refseq_name": "PDZ domain-containing protein GIPC3 isoform 1",
        "refseq_ac": "NP_573568",
        "gene_names_uniprotkb": "GIPC3; C19orf64",
        "gene_names_refseq": "C19orf64; DFNB15; DFNB72; DFNB95; GIPC3",
        "protein_names_uniprotkb": "PDZ domain-containing protein GIPC3",
        "protein_names_refseq": "PDZ domain-containing protein GIPC3 isoform 1; PDZ domain-containing protein GIPC3",
        "tax_id": 9606,
        "disease": "autosomal recessive nonsyndromic deafness 15 (Disease Ontology:DOID:0110470); Parkinson's disease (Disease Ontology:DOID:14330)",
        "pathway": " (hsa:126326)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11237011;11836571;21326233;21660509;25296581;29242379;29605370;31154438;32157095;33168789;34071867;35051231;35494241",
        "class_list": "",
        "function": "Genetic Variant c.245A>G (p.Asn82Ser) in GIPC3 Gene Is a Frequent Cause of Hereditary Nonsyndromic Sensorineural Hearing Loss in Chuvash Population. Publication Status: Online-Only, [RefSeq, PubMed]; Low incidence of GIPC3 variants among the prelingual hearing impaired from southern India., [RefSeq, PubMed]; Molecular cloning and characterization of human GIPC3, a novel gene homologous to human GIPC1 and GIPC2, [RefSeq, PubMed]; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion., [UniProtKB]; The protein encoded by this gene belongs to the GIPC family. Studies in mice suggest that this gene is required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion in the ear. Mutations in this gene are associated with autosomal recessive deafness. [provided by RefSeq, Dec 2011]., [RefSeq]; This study expands the mutational spectrum of GIPC3 in autosomal recessive nonsyndromic hearing impairment., [RefSeq, PubMed]; This study is the first report of the contribution of theGIPC3 gene to hearing loss in the Iranian population, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75227",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q8TF64-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WUU5-1",
        "uniprot_id": "GATD1_HUMAN",
        "mass": 28690.0,
        "length": 269,
        "protein_name": "GATA zinc finger domain-containing protein 1",
        "gene_name": "GATAD1",
        "organism": "Human",
        "refseq_name": "GATA zinc finger domain-containing protein 1 isoform 1",
        "refseq_ac": "NP_066990",
        "gene_names_uniprotkb": "GATAD1; ODAG",
        "gene_names_refseq": "CMD2B; GATAD1; ODAG; RG083M05.2",
        "protein_names_uniprotkb": "GATA zinc finger domain-containing protein 1; Ocular development-associated gene protein",
        "protein_names_refseq": "GATA zinc finger domain-containing protein 1 isoform 1; ocular development-associated gene protein",
        "tax_id": 9606,
        "disease": "dilated cardiomyopathy 2B (Disease Ontology:DOID:0110441)",
        "pathway": " (hsa:57798)",
        "pathway_count": 1,
        "publication_count": 35,
        "publication_id_list": "11237011;20068231;20850016;21965549;24462704;25576301;25755297;26154972;26992070;27600516;28228285;28832583;28834231;29242379;29266303;29508533;29557506;29769354;31844290;32157095;32357974;32502341;32897882;32938616;33717175;33912179;33981976;34019948;34171305;34932366;35051231;35580925;36284347;37567972;38443846",
        "class_list": "",
        "function": "CRISPR screen identifies GATAD1 as a synthetic lethal target with CDK4/6 inhibitors in estrogen receptor-positive breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3)., [UniProtKB, PubMed]; GATAD1 expression was significantly decreased in the third-trimester placentas associated with preeclampsia than those associated with normal pregnancy., [RefSeq, PubMed]; GATAD1 mutation is associated with autosomal recessive dilated cardiomyopathy., [RefSeq, PubMed]; GATAD1 plays a pivotal oncogenic role in hepatocellular carcinoma by directly inducing PRL3 transcription to activate the Akt signaling pathway. GATAD1 may serve as an independent poor prognostic factor for hepatocellular carcinoma patients, [RefSeq, PubMed]; Knockdown of circ-Gatad1 alleviates LPS induced HK2 cell injury via targeting miR-22-3p/TRPM7 axis in septic acute kidney. Erratum:[BMC Nephrol. 2024 Apr 25;25(1):147. doi: 10.1186/s12882-024-03580-4. PMID: 38664673] Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene contains a zinc finger at the N-terminus, and is thought to bind to a histone modification site that regulates gene expression. Mutations in this gene have been associated with autosomal recessive dilated cardiomyopathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RE37;D6W5Q5;Q8N5Y5;Q99995;Q9H689",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043565 sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization",
        "synthesized_glycan_count": 0,
        "hit_score": 3.8,
        "record_id": "Q8WUU5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WWP7-1",
        "uniprot_id": "GIMA1_HUMAN",
        "mass": 34369.0,
        "length": 306,
        "protein_name": "GTPase IMAP family member 1",
        "gene_name": "GIMAP1",
        "organism": "Human",
        "refseq_name": "GTPase IMAP family member 1",
        "refseq_ac": "NP_570115",
        "gene_names_uniprotkb": "GIMAP1; IMAP1",
        "gene_names_refseq": "GIMAP1; HIMAP1; IAN2; IMAP1; IMAP38",
        "protein_names_uniprotkb": "GTPase IMAP family member 1; Immunity-associated protein 1; hIMAP1",
        "protein_names_refseq": "GTPase IMAP family member 1; immune-associated nucleotide-binding protein 2; immunity associated protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:170575)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "11814688;15592455;16959974;18701445;20194894;23454188;24626161;25502872;27726376;28832583;29242379;29493099;29557506;29786170;31848261;32983136;33043033;35051231;35580925",
        "class_list": "",
        "function": "GIMAP1 and GIMAP4 genes are up-regulated by IL-12 and other Th1 differentiation-inducing cytokines in cells induced to differentiate toward Th1 lineage and down-regulated by IL-4 in cells induced to Th2., [RefSeq, PubMed]; GIMAP1 and SERHL variants may be important for appendicular lean mass Publication Status: Online-Only, [RefSeq, PubMed]; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity)., [UniProtKB]; Shows a critical role for the related mouse gene in mature lymphocyte development and survival., [RefSeq, PubMed]; The himap1 gene belongs to a gene family clustered on chromosome 7q32-36 within a region highly syntenic to the mouse imap38 locus on chromosome 6B., [RefSeq, PubMed]; This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene is thought to be involved in the differentiation of T helper (Th) cells of the Th1 lineage, and the related mouse gene has been shown to be critical for the development of mature B and T lymphocytes. Read-through transcription exists between this gene and the downstream GIMAP5 (GTPase, IMAP family member 5) gene. [provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCI3;Q8NAZ0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q8WWP7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92820-1",
        "uniprot_id": "GGH_HUMAN",
        "mass": 35964.0,
        "length": 318,
        "protein_name": "Gamma-glutamyl hydrolase",
        "gene_name": "GGH",
        "organism": "Human",
        "refseq_name": "gamma-glutamyl hydrolase isoform 1 precursor",
        "refseq_ac": "NP_003869",
        "gene_names_uniprotkb": "GGH",
        "gene_names_refseq": "GATD10; GGH; GH",
        "protein_names_uniprotkb": "Gamma-glutamyl hydrolase; 3.4.19.9; Conjugase; GH; Gamma-Glu-X carboxypeptidase",
        "protein_names_refseq": "gamma-Glu-X carboxypeptidase; gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); gamma-glutamyl hydrolase isoform 1 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8836);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 66,
        "publication_id_list": "10.1007/s00018-021-03863-1;10.1101/2023.09.13.557529;10527932;10570974;11005824;11237011;11953431;12643545;16945597;17081065;23090970;23650620;24190977;25502872;25576301;26375851;26992070;27920218;28063628;28467828;28834231;29242379;29317506;29393594;29557506;29632046;29741879;29786170;30573663;30779550;30833945;31154438;31217245;31611695;31739835;31844290;32157095;32265295;32295690;32350084;32488085;32938616;33592498;33691108;33936100;33968037;34019948;34089345;34185709;34357683;34433824;35040120;35051231;35154160;35251023;35289036;36215666;36241641;36569910;37074911;37938771;38665916;40596516;40914422;8692836;8816764",
        "class_list": "",
        "function": "A gamma-glutamyl hydrolase lacking the signal peptide confers susceptibility to folates/antifolates in acute lymphoblastic leukemia cells., [RefSeq, PubMed]; Frequency distribution of five SNPs in human GGH gene and their effects on clinical outcomes of Chinese pediatric patients with acute lymphoblastic leukemia., [RefSeq, PubMed]; Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate (PubMed:11005824, PubMed:8816764). May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates., [UniProtKB, PubMed, PubMed]; Interaction between glycolysischolesterol synthesis axis and tumor microenvironment reveal that gamma-glutamyl hydrolase suppresses glycolysis in colon cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The role of transcription factor Sp1 in the regulation of gamma-glutamyl hydrolase gene expression by the rs3758149 polymorphism in CEM/C1 cells., [RefSeq, PubMed]; This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 52,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "1.8.3.2;4.6.1.19;3.2.1.24;2.7.1.35;1.1.1.42;1.6.2.2;3.4.21.-;1.16.3.1;3.2.1.51;4.1.2.13;3.5.3.1;1.11.2.2;3.2.1.-;3.2.1.22;3.4.23.5;3.4.21.4;3.2.1.52;3.2.1.31;3.4.21.37;3.4.21.20;2.3.1.16;2.3.1.9;2.3.1.155;3.3.2.6;3.4.11.4;4.6.1.18;3.4.16.5;3.4.16.-;2.4.1.1;3.1.27.-;3.4.24.35;3.1.6.8;3.1.6.14;3.1.6.12;3.2.1.23;1.4.3.22;1.4.3.-;1.1.1.205;3.5.1.26;3.4.24.34;3.4.21.76;3.4.22.27;2.7.11.24;3.1.3.48;1.11.1.27;3.1.1.4;2.3.1.23;3.5.4.5;3.1.6.4;5.4.2.2;2.7.10.2;3.1.21.-;3.6.1.-;3.6.5.2;2.3.3.8;3.4.14.1;3.6.4.6;3.2.1.17;3.1.1.-;2.7.11.13;3.2.1.14;3.5.1.23;3.5.1.-;3.5.1.109;2.3.2.5;6.3.4.21;1.8.4.-;5.3.4.1;3.6.1.6;3.4.19.9;3.2.1.18;1.6.5.5;3.1.3.16;5.3.99.3;2.1.1.348;2.1.1.9;3.5.1.3;3.5.4.4;3.4.18.1;3.4.14.2;3.2.1.166;3.5.3.15",
        "go_molecular_function": "GO:0034722 gamma-glutamyl-peptidase activity;GO:0008242 omega peptidase activity;GO:0008238 exopeptidase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0046900 tetrahydrofolylpolyglutamate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 12.4,
        "record_id": "Q92820-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96IG2-1",
        "uniprot_id": "FXL20_HUMAN",
        "mass": 48423.0,
        "length": 436,
        "protein_name": "F-box/LRR-repeat protein 20",
        "gene_name": "FBXL20",
        "organism": "Human",
        "refseq_name": "F-box/LRR-repeat protein 20 isoform 2",
        "refseq_ac": "NP_001171835",
        "gene_names_uniprotkb": "FBXL20; FBL2",
        "gene_names_refseq": "FBXL20; Fbl20; Fbl2",
        "protein_names_uniprotkb": "F-box/LRR-repeat protein 20; F-box and leucine-rich repeat protein 20; F-box/LRR-repeat protein 2-like",
        "protein_names_refseq": "F-box protein FBL2; F-box/LRR-repeat protein 20 isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84961);  (R-HSA-8951664);  (R-HSA-983168)",
        "pathway_count": 3,
        "publication_count": 164,
        "publication_id_list": "10535940;10597293;10811609;10878807;10973499;11062501;11069780;11237011;11259415;11292861;11292862;11350924;11454738;11585840;11733065;11961546;12101228;12186903;12504025;12504026;12526791;12538644;12609982;12646216;12682069;12759363;12816948;14690597;14734113;14757770;15224091;15224092;15282312;15361859;15367669;15537541;15571818;15572695;15574592;15601839;15652483;15688063;15694336;15799966;16171779;16401342;16547496;16595681;16647857;16707496;16790436;16849449;16943200;16954532;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18088087;18093314;18206966;18578522;18662542;18669648;18775313;18776931;18805092;18826954;18851830;18926707;19028597;19250909;19321346;19352404;19452197;19489725;19617556;19748355;19851334;19874575;19940261;20230923;21447816;21463634;21778237;21863050;21940857;22306028;22466964;22537386;2261476;22959436;23023584;23186163;23201271;23333871;23401859;23453757;23535662;23535663;23563313;23583660;23912815;23986495;24076655;24275569;24366543;24636985;24793695;24793696;25314029;25349211;25355947;25531226;25593308;25880248;26344709;26460955;26632597;26906416;27030794;27222660;27565346;27846572;27862975;28115426;28832583;28904123;29153394;29242379;29393594;29508533;29557506;30315122;30610225;31154438;31844290;31848261;32005965;32157095;32284348;32350084;32357974;32387766;32502341;32938616;32983136;33444648;33592498;33912179;34587475;35051231;35112462;35251023;35580925;36374774;9380723;9668046;9790970;9887101;9891082",
        "class_list": "",
        "function": "FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX., [RefSeq, PubMed]; FBXL20-mediated ubiquitination triggers the proteasomal degradation of 4-1BB., [RefSeq, PubMed]; Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]., [RefSeq]; SP1-induced PROX1-AS1 contributes to tumor progression by regulating miR-326/FBXL20 axis in colorectal cancer., [RefSeq, PubMed]; Study concludes FBXL20 plays an essential role in the carcinogenesis of colorectal adenocarcinoma and promotes carcinogenesis through the regulation of the Wnt signaling pathway and caspase activation, [RefSeq, PubMed]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity)., [UniProtKB]; Which provides a signal to promote its ubiquitination and proteasomal degradation mediated by FBXL20 and the associated Skp1-Cullin1 complex, leading to inhibition of autophagy and receptor endocytosis, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K729;Q38J52",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex;GO:0098793 presynapse;GO:0098685 Schaffer collateral - CA1 synapse",
        "go_biological_process": "GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:2000300 regulation of synaptic vesicle exocytosis;GO:0099575 regulation of protein catabolic process at presynapse, modulating synaptic transmission",
        "synthesized_glycan_count": 0,
        "hit_score": 16.5,
        "record_id": "Q96IG2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9GZZ7-1",
        "uniprot_id": "GFRA4_HUMAN",
        "mass": 31670.0,
        "length": 299,
        "protein_name": "GDNF family receptor alpha-4",
        "gene_name": "GFRA4",
        "organism": "Human",
        "refseq_name": "GDNF family receptor alpha-4 isoform a precursor",
        "refseq_ac": "NP_071422",
        "gene_names_uniprotkb": "GFRA4",
        "gene_names_refseq": "GFRA4",
        "protein_names_uniprotkb": "GDNF family receptor alpha-4; GDNF receptor alpha-4; GDNFR-alpha-4; GFR-alpha-4; Persephin receptor",
        "protein_names_refseq": "GDNF family receptor alpha-4 isoform a precursor; GDNF receptor alpha-4; GDNFR-alpha-4; GFR receptor alpha 4; GFR-alpha-4; persephin receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64096);  (R-HSA-419037);  (R-HSA-5673001);  (R-HSA-8853659)",
        "pathway_count": 4,
        "publication_count": 102,
        "publication_id_list": "10448070;10508167;10869344;10995764;11000521;11002419;11027663;11090077;11116144;11136978;11237712;11313946;11360177;11390647;11470823;11491658;11546808;11702783;11886862;12032311;12094235;12121613;12242309;12765789;12771945;14506247;14707138;14766744;15044950;15225646;15286081;15356145;1545823;15546878;15569713;16267048;16627759;16684964;1716764;17998941;18059411;18775330;1898771;19279408;19920141;20478380;21102635;21372320;21779497;21779505;21993244;22569528;22589270;22750304;23103841;23303910;23333276;23443682;23575685;24897931;24937142;25219551;25781681;26085527;2809592;28778966;29090971;29242379;29634418;31135801;32488085;33515383;33592498;36215666;6148751;7665556;7809086;7935463;7972015;8052307;8262246;8394845;8493579;8628282;8631863;8637703;8662982;8663426;8665852;8674117;8710374;8939933;9047384;9192684;9299438;9398268;9407096;9491986;9604935;9764818;9883723;9927426",
        "class_list": "",
        "function": "GDNF/GFRalpha1 is crucial for efficient signal transduction to recruit Ret protein into lipid rafts., [RefSeq, PubMed]; High GFRA4 expression is associated with Hirschsprung's Disease., [RefSeq, PubMed]; MiR-195-5p inhibits proliferation and invasion of nerve cells in Hirschsprung disease by targeting GFRA4., [RefSeq, PubMed]; Receptor for persephin (PSPN), a growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons (PubMed:11116144). Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor (PubMed:11116144). May be important in C-cell development and, in the postnatal development of the adrenal medulla (PubMed:11116144)., [UniProtKB, PubMed]; Results support that aberrant CpG hypermethylation at least partly accounts for GFRA4 silencing in HSCR, which impairs its protective role in enteric nervous system., [RefSeq, PubMed]; The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5JT74;Q9H191;Q9H192",
        "ec_number_list": "",
        "go_molecular_function": "GO:0016167 glial cell-derived neurotrophic factor receptor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway;GO:0007399 nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 10.3,
        "record_id": "Q9GZZ7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H1K4-1",
        "uniprot_id": "GHC2_HUMAN",
        "mass": 33849.0,
        "length": 315,
        "protein_name": "Mitochondrial glutamate carrier 2",
        "gene_name": "SLC25A18",
        "organism": "Human",
        "refseq_name": "mitochondrial glutamate carrier 2",
        "refseq_ac": "NP_001290413",
        "gene_names_uniprotkb": "SLC25A18; GC2",
        "gene_names_refseq": "GC2; SLC25A18",
        "protein_names_uniprotkb": "Mitochondrial glutamate carrier 2; GC-2; Glutamate/H(+) symporter 2; Solute carrier family 25 member 18",
        "protein_names_refseq": "glutamate/H(+) symporter 2; mitochondrial glutamate carrier 2; solute carrier family 25 (glutamate carrier), member 18; solute carrier family 25 (mitochondrial carrier), member 18",
        "tax_id": 9606,
        "disease": "intrahepatic cholestasis (Disease Ontology:DOID:1852); common bile duct disease (Disease Ontology:DOID:4137); citrullinemia (Disease Ontology:DOID:9273)",
        "pathway": " (hsa:83733);  (R-HSA-442660);  (R-HSA-9856872)",
        "pathway_count": 3,
        "publication_count": 40,
        "publication_id_list": "10446133;10684912;10889531;10973981;11381032;11698620;11897791;12115694;12151341;15286787;15286788;15565635;15592994;15632147;16226721;16751771;16920706;17502375;17726476;18599538;2008212;22395867;23266187;2387399;24275569;25637873;2775751;29431636;29557506;3052244;31538237;38871013;4687397;7651355;7874447;8125921;8183239;8597574;8632143;9845349",
        "class_list": "",
        "function": "Compares and contrasts all the known human SLC25A* genes and includes functional information. Review article, [RefSeq, PubMed]; Increased expression of SLC25A18 is associated with Alzheimer's disease and is involved in Abeta42-induced mitochondrial dysfunction and apoptosis in neuronal cells., [RefSeq, PubMed]; Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (symport system)., [UniProtKB, PubMed]; The genes CECR2, SLC25A18 and ATP6V1E1, mapping within the critical region for cat eye syndrome (CES), may be responsible for anorectal, renal and preauricular anomalies in patients with CES., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005280 amino acid:proton symporter activity;GO:0005313 L-glutamate transmembrane transporter activity;GO:0015183 L-aspartate transmembrane transporter activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane",
        "go_biological_process": "GO:0006836 neurotransmitter transport;GO:0015810 aspartate transmembrane transport;GO:0015813 L-glutamate transmembrane transport;GO:0043490 malate-aspartate shuttle",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "Q9H1K4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H227-1",
        "uniprot_id": "GBA3_HUMAN",
        "mass": 53696.0,
        "length": 469,
        "protein_name": "Cytosolic beta-glucosidase",
        "gene_name": "GBA3",
        "organism": "Human",
        "refseq_name": "cytosolic beta-glucosidase isoform b",
        "refseq_ac": "NP_001121904",
        "gene_names_uniprotkb": "GBA3; CBGL1; CBG",
        "gene_names_refseq": "CBGL1; CBG; GBA3; GLUC; KLRP",
        "protein_names_uniprotkb": "Cytosolic beta-glucosidase; 3.2.1.21; 3.2.1.45; 3.2.1.46; Cytosolic GCase; Cytosolic beta-glucosidase-like protein 1; Cytosolic galactosylceramidase; Cytosolic glucosylceramidase; Cytosolic glycosylceramidase; Glucosidase beta acid 3; Glucosylceramidase beta 3; KLrP; Klotho-related protein",
        "protein_names_refseq": "cytosolic GCase; cytosolic beta-glucosidase isoform b; cytosolic beta-glucosidase-like protein 1; cytosolic galactosylceramidase; cytosolic glucosylceramidase; cytosolic glycosylceramidase; glucosidase beta acid 3; glucosidase, beta, acid 3 (cytosolic); klotho-related protein",
        "tax_id": 9606,
        "disease": "kidney disease (Disease Ontology:DOID:557)",
        "pathway": " (hsa:57733);  (R-HSA-9840310)",
        "pathway_count": 2,
        "publication_count": 116,
        "publication_id_list": "10191093;10196694;10406958;10781797;10823942;10861246;10942779;10993717;11043382;11350180;11389701;11489889;11707436;11784319;12374214;12510003;12518053;12566438;12594539;12662933;12667141;12885774;12888274;12909021;1352293;1352993;15003450;15213228;15322500;15458386;15714521;15773042;15845354;16229686;16230343;1634229;16478472;16517606;16595074;16698036;1670590;1678251;17105727;1718266;1720305;1740330;17555766;1756715;17595169;1840600;18524657;18662675;1889421;1907800;1915858;19405096;19836391;2001789;20728381;235289;239890;2562955;26193330;26724485;2717620;28126847;29393594;29443946;29557506;2960521;2965147;29692406;2970528;2971395;29747811;2976757;29802621;3014515;3048308;31154438;3136930;31495489;3158659;32412773;32665690;33361282;3456607;35580925;36010968;36284347;38253038;38428407;39940;5135907;5164093;527942;5822067;7504405;7628016;7730378;7744740;7852280;8281145;8370580;8399327;8573994;8591035;8663398;8804427;8889578;8955159;8985184;9217013;9338580;9520418;9521684",
        "class_list": "glycogene;glycosylhydrolase",
        "function": "Decreased expression of GBA3 correlates with a poor prognosis in hepatocellular carcinoma patients., [RefSeq, PubMed]; GBA3 promotes fatty acid oxidation and alleviates non-alcoholic fatty liver by increasing CPT2 transcription., [RefSeq, PubMed]; GBA3: a polymorphic pseudogene in humans that experienced repeated gene loss during mammalian evolution. Publication Status: Online-Only, [RefSeq, PubMed]; Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides (PubMed:11389701, PubMed:11784319, PubMed:17595169, PubMed:20728381, PubMed:26724485, PubMed:33361282). Has a significant glucosylceramidase activity in vitro (PubMed:17595169, PubMed:26724485). However, that activity is relatively low and its significance in vivo is not clear (PubMed:17595169, PubMed:20728381, PubMed:26724485). Hydrolyzes galactosylceramides/GalCers, glucosylsphingosines/GlcSphs and galactosylsphingosines/GalSphs (PubMed:17595169). However, the in vivo relevance of these activities is unclear (PubMed:17595169). It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens in vitro and could therefore play a role in the metabolism of xenobiotics (PubMed:11784319). Possesses transxylosylase activity in vitro using xylosylated ceramides/XylCers (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) as xylosyl donors and cholesterol as acceptor (PubMed:33361282). Could also play a role in the catabolism of cytosolic sialyl free N-glycans (PubMed:26193330)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; No correlation was observed between GBA3 1368A/T haplotypes and severity of type 1 Gaucher disease manifestation GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The protein encoded by this gene is a cytosolic enzyme that can hydrolyze several types of glycosides. The enzyme has its highest activity at neutral pH and is predominantly expressed in human liver, kidney, intestine, and spleen. This gene is a polymorphic pseudogene, with the most common allele being the functional allele that encodes the full-length protein. Some individuals contain a single nucleotide polymorphism that results in a premature stop codon in the coding region, and therefore this allele is pseudogenic due to the failure to produce a functional full-length protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2022]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q32LY7;Q3MIH4;Q53GG8;Q6NSF4;Q8NHT8;Q9H3T4;Q9H4C6",
        "ec_number_list": "3.2.1.45;2.4.1.-;3.2.1.-;3.2.1.46;3.2.1.21",
        "go_molecular_function": "GO:0004348 glucosylceramidase activity;GO:0017042 glycosylceramidase activity;GO:0008422 beta-glucosidase activity;GO:0004565 beta-galactosidase activity;GO:0004336 galactosylceramidase activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:1902494 catalytic complex",
        "go_biological_process": "GO:0006680 glucosylceramide catabolic process;GO:0050821 protein stabilization;GO:0016139 glycoside catabolic process;GO:0046477 glycosylceramide catabolic process;GO:0046479 glycosphingolipid catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 11.9,
        "record_id": "Q9H227-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9HCC8-1",
        "uniprot_id": "GDE3_HUMAN",
        "mass": 61729.0,
        "length": 539,
        "protein_name": "Glycerophosphodiester phosphodiesterase 3",
        "gene_name": "GDPD2",
        "organism": "Human",
        "refseq_name": "glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform 3",
        "refseq_ac": "NP_001164662",
        "gene_names_uniprotkb": "GDPD2; GDE3; OBDPF; PRO4418",
        "gene_names_refseq": "GDE3; GDPD2; OBDPF",
        "protein_names_uniprotkb": "Glycerophosphodiester phosphodiesterase 3; 3.1.4.-; 3.1.4.43; Glycerophosphodiester phosphodiesterase domain-containing protein 2; Glycerophosphoinositol inositolphosphodiesterase; Lysophosphatidylinositol-specific ectophospholipase C; Osteoblast differentiation promoting factor",
        "protein_names_refseq": "glycerophosphodiester phosphodiesterase 3; glycerophosphodiester phosphodiesterase domain-containing protein 2; glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform 3; glycerophosphoinositol inositolphosphodiesterase GDPD2; osteoblast differentiation promoting factor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54857)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "12933806;12975309;19596859;28849762;29557506;32629025;32917725;35182431;35580925",
        "class_list": "",
        "function": "Calcium-dependent ecto-phospholipase C that cleaves the phosphodiester bond between the glycerol backbone and phosphate group of glycerophospholipids at the cell surface, regulating multiple signaling pathways (PubMed:28849762, PubMed:32629025, PubMed:32917725). Substrates include GPI-anchored proteins, which are released from the membrane upon cleavage of the inositol-phosphate linkage. For example, cleavage and release of UPAR/PLAUR regulates cell-matrix adhesion and extracellular matrix remodeling (PubMed:28849762). Also cleaves the glycosylphosphatidylinositol (GPI) anchor of metalloproteases TRABD2A and TRABD2B, releasing them from the plasma membrane. This release modulates their regulation of Wnt signaling (PubMed:35182431). Also hydrolyzes lysophosphatidylinositol (LPI) to monoacylglycerol and inositol-1-phosphate. Converts 2-arachidonoyl-LPI, the endogenous GPR55 agonist, into 2-arachidonoylglycerol (2-AG), an endocannabinoid that activates CNR1/CNR2. Thereby, acts as a switch redirecting signaling from GPR55 to CNR1/CNR2 within the endocannabinoid system that could alternatively regulate osteoblast proliferation and differentiation (PubMed:32629025, PubMed:32917725). Can also cleave glycerophosphoinositol to glycerol and inositol-1-phosphate in vitro (By similarity). May also play a role in remodeling of the actin cytoskeleton (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; GDE3 is a novel seven-transmembrane protein with a GP-PDE-like extracellular motif expressed during osteoblast differentiation that accelerates the program of osteoblast differentiation and is involved in morphological change of cells, [RefSeq, PubMed]; GDE3 substrate GroPIns is a candidate mediator for osteoblast proliferation, [RefSeq, PubMed]; Glycerophosphodiesterase 3 (GDE3) is a lysophosphatidylinositol-specific ectophospholipase C acting as an endocannabinoid signaling switch., [RefSeq, PubMed]; The results establish GDE3 as a negative regulator of the uPAR signaling network and, furthermore, highlight GPI-anchor hydrolysis as a cell-intrinsic mechanism to alter cell behavior. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the glycerophosphodiester phosphodiesterase enzyme family. The encoded protein hydrolyzes glycerophosphoinositol to produce inositol 1-phosphate and glycerol. This protein may have a role in osteoblast differentiation and growth. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DRH4;B4DVC9;Q9NXJ6",
        "ec_number_list": "3.1.4.-;3.1.4.2;3.1.4.43",
        "go_molecular_function": "GO:0047394 glycerophosphoinositol inositolphosphodiesterase activity;GO:0046872 metal ion binding;GO:0004629 phospholipase C activity;GO:0008081 phosphoric diester hydrolase activity;GO:0008889 glycerophosphodiester phosphodiesterase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030027 lamellipodium",
        "go_biological_process": "GO:0070446 negative regulation of oligodendrocyte progenitor proliferation;GO:0009306 protein secretion;GO:0006505 GPI anchor metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q9HCC8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9P109-1",
        "uniprot_id": "GCNT4_HUMAN",
        "mass": 53052.0,
        "length": 453,
        "protein_name": "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4",
        "gene_name": "GCNT4",
        "organism": "Human",
        "refseq_name": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4",
        "refseq_ac": "NP_001353666",
        "gene_names_uniprotkb": "GCNT4",
        "gene_names_refseq": "C2GNT3; GCNT4; LINC01336",
        "protein_names_uniprotkb": "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4; 2.4.1.102; C2GnT3; Core 2-branching enzyme 3; Core2-GlcNAc-transferase 3",
        "protein_names_refseq": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4; core 2 beta-1,6-N-acetylglucosaminyltransferase 3; core 2-branching enzyme 3; core2-GlcNAc-transferase 3; glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase); long intergenic non-protein coding RNA 1336",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51301);  (R-HSA-913709)",
        "pathway_count": 2,
        "publication_count": 30,
        "publication_id_list": "10330415;10430883;10753916;11042166;11283017;11304796;11821425;12855678;1329093;15486459;15560372;15620693;17113861;18537974;22183981;24643043;29331515;29493099;33592498;34696660;35051231;35970245;38180297;7655172;9295285;9394011;9417100;9435216;9915862;9988682",
        "class_list": "glycogene;glycosyltransferase",
        "function": "CircPRDM5 inhibits the proliferation, migration, invasion, and glucose metabolism of gastric cancer cells by reducing GCNT4 expression in a miR-485-3p-dependent manner., [RefSeq, PubMed]; Circ_0005758 impedes gastric cancer progression through miR-1229-3p/GCNT4 feedback loop., [RefSeq, PubMed]; Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. Does not have core 4 O-glycan or I-branching enzyme activity., [UniProtKB, PubMed]; MicroRNA MiR-130a-3p promotes gastric cancer by targeting Glucosaminyl N-acetyl transferase 4 (GCNT4) to regulate the TGF-beta1/SMAD3 pathway., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 518,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "2.4.1.102;2.4.1.150;2.4.1.148;2.4.1.-",
        "go_molecular_function": "GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008375 acetylglucosaminyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "Q9P109-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UBU3-1",
        "uniprot_id": "GHRL_HUMAN",
        "mass": 12911.0,
        "length": 117,
        "protein_name": "Appetite-regulating hormone",
        "gene_name": "GHRL",
        "organism": "Human",
        "refseq_name": "appetite-regulating hormone isoform 2 preproprotein",
        "refseq_ac": "NP_001128413",
        "gene_names_uniprotkb": "GHRL; MTLRP; PRO1066",
        "gene_names_refseq": "GHRL; MTLRP",
        "protein_names_uniprotkb": "Appetite-regulating hormone; Growth hormone secretagogue; Growth hormone-releasing peptide; Motilin-related peptide; Protein M46",
        "protein_names_refseq": "In2c-preproghrelin; appetite-regulating hormone isoform 2 preproprotein; appetite-regulating hormone; ghrelin, growth hormone secretagogue receptor ligand; ghrelin/obestatin preprohormone; ghrelin/obestatin prepropeptide; growth hormone-releasing peptide; motilin-related peptide; prepro-appetite regulatory hormone",
        "tax_id": 9606,
        "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); morbid obesity (Disease Ontology:DOID:11981); Prader-Willi syndrome (Disease Ontology:DOID:11983); cardiovascular system disease (Disease Ontology:DOID:1287); multiple endocrine neoplasia (Disease Ontology:DOID:3125); middle cerebral artery infarction (Disease Ontology:DOID:3525); esophagus adenocarcinoma (Disease Ontology:DOID:4914); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:51738)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "10604470;10930375;11237011;11306336;12414809;12732215;12975309;14521948;15142980;15340161;16322288;17727735;18443287;29557506;35027551",
        "class_list": "",
        "function": "Circulating levels of C-terminal pro-ghrelin peptides are altered in patients with cadiovascular diseases., [RefSeq, PubMed]; Cloning and characterization of the 5(')-flanking region of the ghrelin gene., [RefSeq, PubMed]; Data suggest that the stomach is the major source of circulating ghrelin and that other tissues compensate for the loss of ghrelin production after gastrectomy., [RefSeq, PubMed]; First demonstration of putative obestatin and C-ghrelin specific transcripts and these findings suggest that these ghrelin gene-derived peptides may also be produced independently of preproghrelin Publication Status: Online-Only, [RefSeq, PubMed]; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed:10604470, PubMed:35027551). Octanoylated ghrelin-28 is the most commonly found ghrelin and octanoylation is essential for the activation of the growth hormone secretagogue receptor type 1 (GHSR) (PubMed:11306336, PubMed:35027551). Induces the release of growth hormone from the pituitary (PubMed:10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation., [UniProtKB, PubMed, PubMed, PubMed]; High expression of ghrelin is associated with prostate cancer, [RefSeq, PubMed]; May be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity)., [UniProtKB]; Potential role for upstream stimulatory factor transcription factors in the regulation of human ghrelin expression., [RefSeq, PubMed]; Precursor of the appetite-regulating peptide ghrelin, including ghrelin-27 and ghrelin-28., [UniProtKB, PubMed, PubMed]; This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression. [provided by RefSeq, Nov 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 11,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8CF34;A8CF38;A8CF42;A8DN29;A8DN30;Q86YP8;Q8TAT9;Q9H3R3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031768 ghrelin receptor binding;GO:0001664 G protein-coupled receptor binding;GO:0030296 protein tyrosine kinase activator activity;GO:0016608 growth hormone-releasing hormone activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0030424 axon",
        "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0032095 regulation of response to food;GO:0032100 positive regulation of appetite;GO:0043400 cortisol secretion;GO:0060399 positive regulation of growth hormone receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q9UBU3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UGJ1-1",
        "uniprot_id": "GCP4_HUMAN",
        "mass": 76089.0,
        "length": 667,
        "protein_name": "Gamma-tubulin complex component 4",
        "gene_name": "TUBGCP4",
        "organism": "Human",
        "refseq_name": "gamma-tubulin complex component 4 isoform a",
        "refseq_ac": "NP_001273343",
        "gene_names_uniprotkb": "TUBGCP4; 76P; GCP4",
        "gene_names_refseq": "76P; GCP-4; GCP4; Grip76; MCCRP3; TUBGCP4",
        "protein_names_uniprotkb": "Gamma-tubulin complex component 4; GCP-4; Gamma-ring complex protein 76 kDa; h76p; hGCP4; hGrip76",
        "protein_names_refseq": "gamma tubulin ring complex protein (76p gene); gamma-ring complex protein 76 kDa; gamma-tubulin complex component 4 isoform a; gamma-tubulin complex component 4; gamma-tubulin complex protein 4; tubulin gamma complex associated protein 4",
        "tax_id": 9606,
        "disease": "microcephaly and chorioretinopathy 3 (Disease Ontology:DOID:0080107)",
        "pathway": " (hsa:27229);  (R-HSA-380270);  (R-HSA-380320)",
        "pathway_count": 3,
        "publication_count": 82,
        "publication_id_list": "10.1101/2023.09.13.557529;10562286;11237011;11956313;12221128;12852856;16462731;22898188;23481700;23921553;24714562;24715725;25418920;25576301;25817018;25892735;26154972;26213385;26375851;26992070;27846572;27920218;28063628;28218747;28228285;28411811;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632711;30315122;30410026;30779550;31844290;31937595;31998317;32157095;32161166;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33633747;33691108;33717175;33912179;33936100;33968037;34087483;34211107;34357683;34509645;34932366;35051231;35318648;35561310;35580925;36010968;36215666;36241641;36793126;37038737;37074911;37217939;38305685;38609661;39321809;7769006;7790358;8838651",
        "class_list": "",
        "function": "Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809)., [UniProtKB, PubMed, PubMed, PubMed]; Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Exosomal circTUBGCP4 promotes vascular endothelial cell tipping and colorectal cancer metastasis by activating Akt signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Microcephaly and chorioretinopathy associated with TUBGCP4: a case report and a review of the literature. Review article, [RefSeq, PubMed]; Mutations in TUBGCP4 alter microtubule organization via the gamma-tubulin ring complex in autosomal-recessive microcephaly with chorioretinopathy., [RefSeq, PubMed]; This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 9,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KNK6;Q969X3;Q9NVF0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0043015 gamma-tubulin binding",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0016020 membrane",
        "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007020 microtubule nucleation;GO:0051225 spindle assembly;GO:0051321 meiotic cell cycle;GO:0031122 cytoplasmic microtubule organization",
        "synthesized_glycan_count": 0,
        "hit_score": 9.5,
        "record_id": "Q9UGJ1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UMX1-1",
        "uniprot_id": "SUFU_HUMAN",
        "mass": 53947.0,
        "length": 484,
        "protein_name": "Suppressor of fused homolog",
        "gene_name": "SUFU",
        "organism": "Human",
        "refseq_name": "suppressor of fused homolog isoform 2",
        "refseq_ac": "NP_001171604",
        "gene_names_uniprotkb": "SUFU; PRO1280",
        "gene_names_refseq": "BCNS2; JBTS32; PRO1280; SUFUH; SUFUXL; SUFU",
        "protein_names_uniprotkb": "Suppressor of fused homolog; SUFUH",
        "protein_names_refseq": "negative regulator of hedgehog signaling; suppressor of fused homolog isoform 2; suppressor of fused homolog",
        "tax_id": 9606,
        "disease": "medulloblastoma (Disease Ontology:DOID:0050902); pre-malignant neoplasm (Disease Ontology:DOID:0060071); nevoid basal cell carcinoma syndrome 2 (Disease Ontology:DOID:0070366); Joubert syndrome 32 (Disease Ontology:DOID:0080278); nevoid basal cell carcinoma syndrome (Disease Ontology:DOID:2512); brain glioblastoma multiforme (Disease Ontology:DOID:3073); familial meningioma (Disease Ontology:DOID:4586)",
        "pathway": " (hsa:51684);  (R-HSA-5610780);  (R-HSA-5610783);  (R-HSA-5610785);  (R-HSA-5610787);  (R-HSA-5632684)",
        "pathway_count": 6,
        "publication_count": 185,
        "publication_id_list": "10433824;10559945;10564661;10693759;10806483;10966113;11027307;11252182;11375483;11960000;12050670;12068298;12123571;12138125;12192414;12426310;12435627;12975309;14528312;14603322;14611647;15087129;15115751;15198976;15300262;15367681;15930098;16061793;16136078;16155214;16229832;16254602;16311594;16339192;16371461;16396903;16421275;16459297;16459298;16493421;16611981;16651542;16705181;16707575;16740475;16980583;17027958;17115028;17200122;17283082;17442700;17553904;17641202;17762891;17960137;18327258;18455992;18497258;18669648;18827223;18832070;19000668;19056373;19196978;19223390;19286674;19305393;19365551;19368795;19371734;19533801;19549984;19592253;19608861;19622347;19666503;19684112;19767740;19776033;19818708;19852954;19877275;19878745;19906846;19948480;19955409;19996169;20014402;20016067;20067783;20154143;20207148;20360384;20395968;20412786;20460306;20487519;20512148;20643644;20818436;20844016;20889716;20956384;2105456;21209331;21317289;21695114;21801010;21878643;21921029;22007132;22231273;22365972;22391300;22391301;22982193;23186163;23209152;23332756;23337587;23719536;23725801;23955340;24072710;24217340;24302888;24311597;24339784;24582806;24845016;24854174;24863049;24917297;24925320;24952464;25418920;25576301;25645385;25802875;25892735;26154972;26811146;26929215;26992070;27234298;27846572;27920218;28228285;28832583;28834231;28904123;28965847;29242379;29393594;29632046;29769354;30315122;30429286;30779550;31154438;31217245;31844290;32157095;32265295;32357974;32387766;32488085;32826873;32938616;33537174;33717175;33912179;33968037;34087483;34171305;35051231;35580925;35831023;36010968;36524356;37938771;38529886;39181021;9601642;9874371",
        "class_list": "",
        "function": "Developmental, Cognitive, Ocular Motor, and Neuroimaging Findings Related to SUFU Haploinsufficiency: Unraveling Subtle and Highly Variable Phenotypes., [RefSeq, PubMed]; ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1. Publication Status: Online-Only, [RefSeq, PubMed]; Negative regulator in the hedgehog/smoothened signaling pathway that acts by sequestering the GLI (GI1, GLI2 and GLI3) transcription factors in the cytoplasm (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:12068298, PubMed:12975309, PubMed:15367681, PubMed:22365972, PubMed:24217340, PubMed:24311597, PubMed:27234298, PubMed:28965847, PubMed:35831023). When smoothened signaling is initiated, GLI transcription factors dissociate from SUFU, translocate to the nucleus and activate expression of target genes (PubMed:24311597, PubMed:28965847, PubMed:35831023). In absence of smoothened signaling, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of full-length GLI3 into transcription repressor GLI3R: SUFU participates to GLI3 processing by promoting recruitment of GSK3B to GLI3 (PubMed:24311597, PubMed:28965847). May also act as a negative regulator of beta-catenin signaling (By similarity). Required for normal embryonic development (By similarity). Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]., [RefSeq]; WNT5A, betacatenin and SUFU expression patterns, and the significance of microRNA deregulation in placentas with intrauterine growth restriction., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 15,
        "reported_glycation": 0,
        "reported_snv": 34,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 7,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7LCP7;Q9NT90;Q9NZ07;Q9UHK2;Q9UHM8;Q9UMY0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019901 protein kinase binding;GO:0003714 transcription corepressor activity;GO:0008013 beta-catenin binding;GO:0140311 protein sequestering activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0097546 ciliary base",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0006355 regulation of DNA-templated transcription;GO:0007286 spermatid development;GO:0042308 negative regulation of protein import into nucleus",
        "synthesized_glycan_count": 0,
        "hit_score": 18.6,
        "record_id": "Q9UMX1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UN88-1",
        "uniprot_id": "GBRT_HUMAN",
        "mass": 71988.0,
        "length": 632,
        "protein_name": "Gamma-aminobutyric acid receptor subunit theta",
        "gene_name": "GABRQ",
        "organism": "Human",
        "refseq_name": "gamma-aminobutyric acid receptor subunit theta precursor",
        "refseq_ac": "NP_061028",
        "gene_names_uniprotkb": "GABRQ",
        "gene_names_refseq": "GABRQ; THETA",
        "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit theta; GABA(A) receptor subunit theta; GABAAR subunit theta",
        "protein_names_refseq": "GABA(A) receptor subunit theta; GABAAR subunit theta; gamma-aminobutyric acid (GABA) A receptor, theta; gamma-aminobutyric acid receptor subunit theta precursor; gamma-aminobutyric acid type A receptor theta subunit",
        "tax_id": 9606,
        "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037)",
        "pathway": " (hsa:55879);  (R-HSA-1236394);  (R-HSA-977443)",
        "pathway_count": 3,
        "publication_count": 39,
        "publication_id_list": "10449790;10542332;10804200;10867024;1315307;1321750;15024690;16412217;1664410;17364682;17398006;17545517;18382465;1849271;18721752;19828786;2465923;25418920;26929215;2847710;31154438;31610743;33772085;35152451;35494241;37938771;7565730;7929212;8264558;8382267;8391122;8617750;8632757;8719414;8719416;9135143;9168115;9275162;9556621",
        "class_list": "",
        "function": "A pioneering study indicate role of GABRQ rs3810651 in ASD severity of Indo-Caucasoid female probands. Publication Status: Online-Only, [RefSeq, PubMed]; The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. [provided by RefSeq, Jul 2017]., [RefSeq]; The intracellular domain of GABRQ disrupts GABRB3 homomeric plasma membrane expression., [RefSeq, PubMed]; The severity of behavioural symptoms in FTD is linked to the loss of GABRQ-expressing VENs and pyramidal neurons., [RefSeq, PubMed]; Theta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790, PubMed:16412217). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:10449790, PubMed:16412217)., [UniProtKB, PubMed, PubMed, UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NFN1;Q32MB4;Q9NZK8",
        "ec_number_list": "1.8.-.-;1.8.5.1;1.11.1.-;5.6.1.6",
        "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0004888 transmembrane signaling receptor activity;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex;GO:1902711 GABA-A receptor complex",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q9UN88-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y231-1",
        "uniprot_id": "FUT9_HUMAN",
        "mass": 42071.0,
        "length": 359,
        "protein_name": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9",
        "gene_name": "FUT9",
        "organism": "Human",
        "refseq_name": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9",
        "refseq_ac": "NP_006572",
        "gene_names_uniprotkb": "FUT9",
        "gene_names_refseq": "FUT9; Fuc-TIX",
        "protein_names_uniprotkb": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9; 2.4.1.152; Fuc-TIX; FucT-IX; Fucosyltransferase 9; Fucosyltransferase IX; Galactoside 3-L-fucosyltransferase",
        "protein_names_refseq": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9; alpha-(1,3)-fucosyltransferase 9; fucT-IX; fucosyltransferase 9 (alpha (1,3) fucosyltransferase); fucosyltransferase IX; galactoside 3-L-fucosyltransferase",
        "tax_id": 9606,
        "disease": "candidiasis (Disease Ontology:DOID:1508)",
        "pathway": " (hsa:10690);  (R-HSA-9037629)",
        "pathway_count": 2,
        "publication_count": 36,
        "publication_id_list": "10206952;10212226;10386598;10622713;10929005;11278338;12107078;12222957;12678917;14688233;15158662;1520296;16282604;1702034;17123352;1716630;17335083;1740457;18395013;1977660;23000574;23192350;23263199;24953560;25576301;29593094;32983136;37202521;37674363;7876235;8207002;8240337;8288606;8333853;9219535;9582303",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc-) glycan attached to glycolipids and N- or O-linked glycoproteins. Fucosylates distal type 2 LacNAc and its fucosylated (H-type 2 LacNAc) and sialylated (sialyl-type 2 LacNAc) derivatives to form Lewis x (Lex) (CD15) and Lewis y (Ley) antigenic epitopes involved in cell adhesion and differentiation (PubMed:10386598, PubMed:10622713, PubMed:11278338, PubMed:12107078, PubMed:16282604, PubMed:17335083, PubMed:18395013, PubMed:23192350, PubMed:23263199, PubMed:29593094, PubMed:37202521). Generates Lex epitopes in the brain, presumably playing a role in the maintenance of neuronal stemness and neurite outgrowth in progenitor neural cells (By similarity) (PubMed:17335083, PubMed:23000574). Fucosylates the internal type 2 LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (PubMed:23192350). Can also modify milk oligosaccharides, in particular type 2 tetrasaccharide LNnT (PubMed:37202521)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9., [RefSeq, PubMed]; The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. [provided by RefSeq, Nov 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 3,
        "mined_n_glycosites": 3,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 33,
        "reported_glycation": 0,
        "reported_snv": 451,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T0W4",
        "ec_number_list": "2.4.1.-;2.4.1.65;2.4.1.152",
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0008417 fucosyltransferase activity;GO:0046920 alpha-(1->3)-fucosyltransferase activity;GO:0017083 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0032588 trans-Golgi network membrane;GO:0005802 trans-Golgi network",
        "go_biological_process": "GO:0000271 polysaccharide biosynthetic process;GO:0006688 glycosphingolipid biosynthetic process;GO:0010976 positive regulation of neuron projection development;GO:0005975 carbohydrate metabolic process;GO:0006493 protein O-linked glycosylation",
        "synthesized_glycan_count": 1336,
        "hit_score": 4.1,
        "record_id": "Q9Y231-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A6NCC3-2",
        "uniprot_id": "GOG8O_HUMAN",
        "mass": 71536.0,
        "length": 632,
        "protein_name": "Golgin subfamily A member 8O",
        "gene_name": "GOLGA8O",
        "organism": "Human",
        "refseq_name": "golgin subfamily A member 8O",
        "refseq_ac": "NP_001264237",
        "gene_names_uniprotkb": "GOLGA8O",
        "gene_names_refseq": "GOLGA8O",
        "protein_names_uniprotkb": "Golgin subfamily A member 8O",
        "protein_names_refseq": "Golgin subfamily A member 6-like protein 11; golgin subfamily A member 8O",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:728047)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "31844290;33968037;34087483",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NHZ1;E7ENU5",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0032580 Golgi cisterna membrane;GO:0005801 cis-Golgi network;GO:0000137 Golgi cis cisterna",
        "go_biological_process": "GO:0007030 Golgi organization",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "A6NCC3-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A6NN73-1",
        "uniprot_id": "GOG8C_HUMAN",
        "mass": 67128.0,
        "length": 597,
        "protein_name": "Golgin subfamily A member 8C",
        "gene_name": "GOLGA8CP",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "GOLGA8CP; GOLGA8C",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Golgin subfamily A member 8C",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 3,
        "publication_id_list": "25892735;29557506;31844290",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0032580 Golgi cisterna membrane;GO:0005801 cis-Golgi network;GO:0000137 Golgi cis cisterna",
        "go_biological_process": "GO:0007030 Golgi organization",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "A6NN73-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A7E2F4-1",
        "uniprot_id": "GOG8A_HUMAN",
        "mass": 70117.0,
        "length": 631,
        "protein_name": "Golgin subfamily A member 8A",
        "gene_name": "GOLGA8A",
        "organism": "Human",
        "refseq_name": "golgin subfamily A member 8A isoform 1",
        "refseq_ac": "NP_851422",
        "gene_names_uniprotkb": "GOLGA8A; KIAA0855",
        "gene_names_refseq": "CFAP286; FAP286; GM88; GOLGA8A",
        "protein_names_uniprotkb": "Golgin subfamily A member 8A; 88 kDa Golgi matrix protein; GM88 autoantigen; GM88",
        "protein_names_refseq": "88 kDa Golgi matrix protein; 88-kDa golgi protein; GM88 autoantigen; golgi autoantigen, golgin subfamily a, 8A; golgin subfamily A member 8A isoform 1; golgin subfamily A member 8A; golgin-67",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23015)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11237011;26738811;28832583;29242379;29557506;29741879;33981976;35051231",
        "class_list": "",
        "function": "May be involved in maintaining Golgi structure., [UniProtKB]; The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked, flattened membrane sacs referred to as cisternae. Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins constitute a family of proteins which are localized to the Golgi. This gene encodes a golgin which structurally resembles its family member GOLGA2, suggesting that they may share a similar function. There are many similar copies of this gene on chromosome 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]., [RefSeq]; The microarray analysis and the validation study revealed an increase in Golgin A8 Family, Member A (GOLGA8A) mRNA and protein levels in Intracerebral hemorrhage., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 8851,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7MCY9;B7ZMK5;O94937;Q52M46;Q68DK6;Q9NZG8;Q9NZW0;Q9NZW3",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0032580 Golgi cisterna membrane;GO:0005801 cis-Golgi network;GO:0000137 Golgi cis cisterna",
        "go_biological_process": "GO:0007030 Golgi organization",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "A7E2F4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "D6RF30-1",
        "uniprot_id": "GOG8K_HUMAN",
        "mass": 71556.0,
        "length": 630,
        "protein_name": "Golgin subfamily A member 8K",
        "gene_name": "GOLGA8K",
        "organism": "Human",
        "refseq_name": "golgin subfamily A member 8K",
        "refseq_ac": "NP_001269422",
        "gene_names_uniprotkb": "GOLGA8K",
        "gene_names_refseq": "GOLGA8K",
        "protein_names_uniprotkb": "Golgin subfamily A member 8K",
        "protein_names_refseq": "golgin subfamily A member 8K",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:653125)",
        "pathway_count": 1,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0032580 Golgi cisterna membrane;GO:0005801 cis-Golgi network;GO:0000137 Golgi cis cisterna",
        "go_biological_process": "GO:0007030 Golgi organization",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "D6RF30-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "F8WBI6-1",
        "uniprot_id": "GOG8N_HUMAN",
        "mass": 71524.0,
        "length": 632,
        "protein_name": "Golgin subfamily A member 8N",
        "gene_name": "GOLGA8N",
        "organism": "Human",
        "refseq_name": "golgin subfamily A member 8N",
        "refseq_ac": "NP_001269423",
        "gene_names_uniprotkb": "GOLGA8N",
        "gene_names_refseq": "GOLGA8N",
        "protein_names_uniprotkb": "Golgin subfamily A member 8N",
        "protein_names_refseq": "golgin subfamily A member 8N",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:643699)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "11237011;28832583;29242379;29557506",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0032580 Golgi cisterna membrane;GO:0005801 cis-Golgi network;GO:0000137 Golgi cis cisterna",
        "go_biological_process": "GO:0007030 Golgi organization",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "F8WBI6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P60983-1",
        "uniprot_id": "GMFB_HUMAN",
        "mass": 16713.0,
        "length": 142,
        "protein_name": "Glia maturation factor beta",
        "gene_name": "GMFB",
        "organism": "Human",
        "refseq_name": "glia maturation factor beta",
        "refseq_ac": "NP_004115",
        "gene_names_uniprotkb": "GMFB",
        "gene_names_refseq": "GMFB; GMF",
        "protein_names_uniprotkb": "Glia maturation factor beta; GMF-beta",
        "protein_names_refseq": "GMF-beta; glia maturation factor beta",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2764)",
        "pathway_count": 1,
        "publication_count": 44,
        "publication_id_list": "11237011;1712830;22223895;25576301;26154972;26375851;26992070;27846572;27862975;28228285;28510447;28832583;29242379;29383690;29508533;29557506;29786170;30315122;30484775;31844290;32157095;32161166;32350084;32502341;32897882;32938616;32983136;33141586;33592498;33691108;33912179;33968037;34019948;34725712;34793551;35051231;35561310;35580925;36284347;37307824;38256254;38657921;7598724;9030586",
        "class_list": "",
        "function": "G9a Inhibition Promotes Neuroprotection through GMFB Regulation in Alzheimer's Disease. Publication Status: Online-Only, [RefSeq, PubMed]; GMF acts as an important upstream regulator of PGC-1alpha in promoting dopaminergic neuronal death through its effect on oxidative stress-mediated apoptosis., [RefSeq, PubMed]; MicroRNA-5195-3p alleviates high glucoseinduced injury in human ARPE-19 cells by targeting GMFB. Publication Status: Online-Only, [RefSeq, PubMed]; Parkinson's Disease Dementia Patients: Expression of Glia Maturation Factor in the Brain. Publication Status: Online-Only, [RefSeq, PubMed]; SUMOylation of GMFB regulates its stability and function in retinal pigment epithelial cells under hyperglycemia., [RefSeq, PubMed]; This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R499;P17774;Q9BS35",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0008047 enzyme activator activity;GO:0004860 protein kinase inhibitor activity;GO:0008083 growth factor activity;GO:0071933 Arp2/3 complex binding",
        "go_cellular_component": "GO:0030864 cortical actin cytoskeleton",
        "go_biological_process": "GO:0071846 actin filament debranching;GO:0006468 protein phosphorylation;GO:0007399 nervous system development;GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "P60983-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P47871-1",
        "uniprot_id": "GLR_HUMAN",
        "mass": 54009.0,
        "length": 477,
        "protein_name": "Glucagon receptor",
        "gene_name": "GCGR",
        "organism": "Human",
        "refseq_name": "glucagon receptor precursor",
        "refseq_ac": "NP_000151",
        "gene_names_uniprotkb": "GCGR",
        "gene_names_refseq": "GCGR; GGR; GL-R; MVAH",
        "protein_names_uniprotkb": "Glucagon receptor; GL-R",
        "protein_names_refseq": "glucagon receptor precursor",
        "tax_id": 9606,
        "disease": "Mahvash Disease (Disease Ontology:DOID:0112306); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:2642);  (R-HSA-163359);  (R-HSA-416476);  (R-HSA-418555);  (R-HSA-420092)",
        "pathway_count": 5,
        "publication_count": 121,
        "publication_id_list": "10191087;10322410;10567430;10698200;10727532;10861009;11007482;11015615;11060443;11237011;11742120;11753430;11946536;12036966;12058044;12106601;12120503;12180353;12860470;1333056;13549488;14671004;1517224;15464082;15471943;15765929;15769620;15951850;16182515;16221670;16268778;16313925;16339447;16687412;16754659;16923326;17168849;1739432;18044684;18434541;18515384;18577758;18936096;1905813;19105585;19657311;19876791;19929708;20166139;20167541;20381629;21036126;2163110;22908259;23863937;2417744;24275569;24687066;24714562;2491850;2553411;2553705;25695890;26417854;27111510;2826231;2841328;28514451;2871555;29443750;29557506;29602314;30032256;30294546;30833991;3086311;3127824;31279028;31399091;31844290;31983287;32193322;32226383;32497535;32540603;32618402;32677665;32715661;33049737;35051231;35767325;35784565;36284347;38346960;38424242;3899557;6085243;6192430;6745415;7507321;7589426;7589886;7680413;7700244;7811244;7902709;7937899;8020989;8144028;8340388;8390245;8514797;8664309;8672451;9263355;9287038;9305846;9417641;9651336;9770463;9990065",
        "class_list": "",
        "function": "G protein-coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:32193322, PubMed:38346960). Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent in primary hepatocytes., [RefSeq, PubMed]; Role of Glucagon and Its Receptor in the Pathogenesis of Diabetes. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is the glucagon receptor, a member of the secretin receptor family of class B G-protein-coupled receptors (GPCRs). This receptor plays a critical role in maintaining blood glucose homeostasis by mediating the effects of glucagon, including stimulation of hepatic glycogenolysis and gluconeogenesis. This gene is expressed primarily in the liver and kidney but also in the heart, adrenal glands, pancreas, spleen, thymus, cerebral cortex, adipose tissue, and gastrointestinal tract. Mutations in this gene can impair glucagon signaling, leading to dysregulation of glucose metabolism and contributing to the development of non-insulin-dependent diabetes mellitus (type 2 diabetes). Such defects may result in altered glucose production, insufficient counter-regulation during fasting, and increased susceptibility to hyperglycemia. Inactivating mutations in this gene cause resistance to glucagon which is associated with Mahvash disease. [provided by RefSeq, Mar 2026]., [RefSeq]; The renal glucagon receptor is essential to kidney metabolic and homeostatic functions., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 33,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2M3M5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0017046 peptide hormone binding;GO:0004967 glucagon receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0006091 generation of precursor metabolites and energy;GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007584 response to nutrient;GO:0010628 positive regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 12.6,
        "record_id": "P47871-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15303-1",
        "uniprot_id": "GRM6_HUMAN",
        "mass": 95468.0,
        "length": 877,
        "protein_name": "Metabotropic glutamate receptor 6",
        "gene_name": "GRM6",
        "organism": "Human",
        "refseq_name": "metabotropic glutamate receptor 6 precursor",
        "refseq_ac": "NP_000834",
        "gene_names_uniprotkb": "GRM6; GPRC1F; MGLUR6",
        "gene_names_refseq": "CSNB1B; GPRC1F; GRM6; MGLUR6; mGlu6",
        "protein_names_uniprotkb": "Metabotropic glutamate receptor 6; mGluR6",
        "protein_names_refseq": "glutamate receptor, metabotropic 6; metabotropic glutamate receptor 6 precursor",
        "tax_id": 9606,
        "disease": "congenital stationary night blindness 1B (Disease Ontology:DOID:0110865)",
        "pathway": " (hsa:2916);  (R-HSA-418594);  (R-HSA-420499)",
        "pathway_count": 3,
        "publication_count": 50,
        "publication_id_list": "11007482;11208605;11917125;12120503;1329206;15194188;15576628;15781871;15951850;16249515;16634148;16923326;16959974;17405131;18434541;18577758;20022913;20555319;21148030;23121374;23452348;23674604;23714322;24235081;2534964;27071541;2748346;2834384;29614098;31063016;31677249;31844290;35051231;7476890;7617140;7620613;7623957;7759551;7908515;7937899;8015379;8406495;8887960;9131252;9144337;9144651;9215706;9473604;9844003;9872316",
        "class_list": "",
        "function": "Affected individuals in three of five families carried either compound heterozygous or homozygous mutations in GRM6., [RefSeq, PubMed]; G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision., [UniProtKB, PubMed]; L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Mutations in this gene result in congenital stationary night blindness type 1B. [provided by RefSeq, May 2018]., [RefSeq]; Study reported a rare case of pseudodominantly inherited autosomal recessive congenital stationary night blindness in a family with three co-segregating deleterious variants (p.Arg621Ter, p.Gly51Val, and p.Gly464Arg) of GRM6., [RefSeq, PubMed]; We identified a novel homozygous missense mutation in exon 8 of GRM6 (NM_000843.3)., [RefSeq, PubMed]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 58,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0042803 protein homodimerization activity;GO:0008066 glutamate receptor activity",
        "go_cellular_component": "GO:0035841 new growing cell tip;GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse",
        "go_biological_process": "GO:0009584 detection of visible light;GO:0007626 locomotory behavior;GO:0007268 chemical synaptic transmission;GO:0050908 detection of light stimulus involved in visual perception;GO:0051966 regulation of synaptic transmission, glutamatergic",
        "synthesized_glycan_count": 0,
        "hit_score": 5.1,
        "record_id": "O15303-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15488-1",
        "uniprot_id": "GLYG2_HUMAN",
        "mass": 55184.0,
        "length": 501,
        "protein_name": "Glycogenin-2",
        "gene_name": "GYG2",
        "organism": "Human",
        "refseq_name": "glycogenin-2 isoform a",
        "refseq_ac": "NP_001073324",
        "gene_names_uniprotkb": "GYG2",
        "gene_names_refseq": "GN-2; GN2; GYG2",
        "protein_names_uniprotkb": "Glycogenin-2; 2.4.1.186; GN-2; GN2",
        "protein_names_refseq": "glycogenin glucosyltransferase; glycogenin-2 isoform a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8908);  (R-HSA-3322077);  (R-HSA-3858516);  (R-HSA-3878781);  (R-HSA-70221)",
        "pathway_count": 5,
        "publication_count": 67,
        "publication_id_list": "10487978;10721716;10949035;11237011;11840567;12604216;12825073;12930917;13115432;15118078;15452297;15930137;18040046;18070875;18323634;19699667;20357282;20538597;21248752;21356517;21767668;22248338;23663739;24275569;25416783;25538239;25544560;25576301;25645385;25751106;26216881;2667896;27600516;28453664;2961257;3049072;30779550;31154438;31217245;31844290;32157095;32387766;32488085;33592498;34087483;34509645;35051231;35580925;36010968;38062989;4829444;5264799;5348606;5427280;5461220;7847371;7902568;8420990;8613547;8631325;8755644;8831078;8896567;9346895;9504428;9691087;9857012",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Study demonstrates expression of glycogenin 2 in glycogenin 1-deficient patients, suggesting that glycogenin 2 rescues the formation of glycogen in patients with glycogenin 1 deficiency., [RefSeq, PubMed]; This gene encodes a member of the the glycogenin family. Glycogenin is a self-glucosylating protein involved in the initiation reactions of glycogen biosynthesis. A gene on chromosome 3 encodes the muscle glycogenin and this X-linked gene encodes the glycogenin mainly present in liver; both are involved in blood glucose homeostasis. This gene has a short version on chromosome Y, which is 3' truncated and can not make a functional protein. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]., [RefSeq]; This is the first evaluation of humans without GN2 expression. Our data indicate that GN2 is not required for liver glycogen synthesis and glucagon-stimulated glucose release., [RefSeq, PubMed]; Transcriptome-wide analysis reveals GYG2 as a mitochondria-related aging biomarker in human subcutaneous adipose tissue., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 157,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7WNN6;O15485;O15486;O15487;O15489;O15490",
        "ec_number_list": "3.1.3.-;3.1.3.16;3.1.3.48;2.4.1.186;2.4.1.1;2.4.1.11;2.4.1.18;2.3.2.27",
        "go_molecular_function": "GO:0008466 glycogenin glucosyltransferase activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0005978 glycogen biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "O15488-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15499-1",
        "uniprot_id": "GSC2_HUMAN",
        "mass": 21545.0,
        "length": 205,
        "protein_name": "Homeobox protein goosecoid-2",
        "gene_name": "GSC2",
        "organism": "Human",
        "refseq_name": "homeobox protein goosecoid-2",
        "refseq_ac": "NP_005306",
        "gene_names_uniprotkb": "GSC2; GSCL",
        "gene_names_refseq": "GSC2; GSCL",
        "protein_names_uniprotkb": "Homeobox protein goosecoid-2; GSC-2; GSC-L; Homeobox protein goosecoid-like",
        "protein_names_refseq": "homeobox protein goosecoid-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2928)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "25576301;30524438;9150167;9441739",
        "class_list": "",
        "function": "Goosecoidlike (GSCL), a homeodomain-containing gene, resides in the critical region for VCFS/DGS on 22q11. Velocardiofacial syndrome (VCFS) is a developmental disorder characterized by conotruncal heart defects, craniofacial anomalies, and learning disabilities. VCFS is phenotypically related to DiGeorge syndrome (DGS) and both syndromes are associated with hemizygous 22q11 deletions. Because many of the tissues and structures affected in VCFS/DGS derive from the pharyngeal arches of the developing embryo, it is believed that haploinsufficiency of a gene involved in embryonic development may be responsible for its etiology. The gene is expressed in a limited number of adult tissues, as well as in early human development. [provided by RefSeq, Jul 2008]., [RefSeq]; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0009653 anatomical structure morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "O15499-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15544-1",
        "uniprot_id": "GR6_HUMAN",
        "mass": 16056.0,
        "length": 149,
        "protein_name": "Protein GR6",
        "gene_name": "LINC01565",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "LINC01565; C3orf27; GR6",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Protein GR6",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "35051231;9307271",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "O15544-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60547-1",
        "uniprot_id": "GMDS_HUMAN",
        "mass": 41950.0,
        "length": 372,
        "protein_name": "GDP-mannose 4,6 dehydratase",
        "gene_name": "GMDS",
        "organism": "Human",
        "refseq_name": "GDP-mannose 4,6 dehydratase isoform 2",
        "refseq_ac": "NP_001240775",
        "gene_names_uniprotkb": "GMDS",
        "gene_names_refseq": "GMDS; GMD; SDR3E1",
        "protein_names_uniprotkb": "GDP-mannose 4,6 dehydratase; 4.2.1.47; GDP-D-mannose dehydratase; GMD",
        "protein_names_refseq": "GDP-D-mannose dehydratase; GDP-mannose 4,6 dehydratase isoform 2; short chain dehydrogenase/reductase family 3E, member 1",
        "tax_id": 9606,
        "disease": "congenital disorder of glycosylation type IIc (Disease Ontology:DOID:0070255); open-angle glaucoma (Disease Ontology:DOID:1067)",
        "pathway": " (hsa:2762);  (R-HSA-6787639)",
        "pathway_count": 2,
        "publication_count": 81,
        "publication_id_list": "11326280;11831876;12056818;12753898;16086588;19413330;22544926;23186163;23481700;23774504;23922970;24715725;25502872;25576301;25645385;26154972;26375851;26992070;27600516;27738779;27846572;27862975;27920218;28218747;28228285;28832583;28834231;29242379;29314611;29393594;29437277;29557506;29632711;29786170;29843634;30315122;30379171;30429286;30524438;30573663;30779550;31020640;31375564;31844290;31848261;31937595;31998317;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34405274;34509645;35051231;35251023;35318648;35561310;35580925;36010968;36215666;36241641;8910301;9525924;9603974",
        "class_list": "glycogene",
        "function": "Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose., [UniProtKB, PubMed, PubMed]; FX takes part in the cascade of events leading to the extravasation of activated lymphocytes., [RefSeq, PubMed]; GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]., [RefSeq]; Study findings suggest that GMDS upregulation is critical for cell proliferation and survival in human lung adenocarcinoma and might serve as a potential biomarker for lung adenocarcinoma diagnosis and treatment. Publication Status: Online-Only, [RefSeq, PubMed]; We present an analysis of the sequence and structural features governing TNKS interactions with two model binding partners: the PARylated partner telomeric repeat-binding factor 1 (TRF1) and the non-PARylated partner GDP-mannose 4,6-dehydratase (GMD)., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 376,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PI88;O75357;Q5T954;Q6FH09;Q9UGZ3;Q9UJK9",
        "ec_number_list": "4.2.1.47",
        "go_molecular_function": "GO:0008446 GDP-mannose 4,6-dehydratase activity;GO:0042802 identical protein binding;GO:0070401 NADP+ binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0019673 GDP-mannose metabolic process;GO:0042351 'de novo' GDP-L-fucose biosynthetic process;GO:0007219 Notch signaling pathway;GO:0042350 GDP-L-fucose biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 8.4,
        "record_id": "O60547-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75311-1",
        "uniprot_id": "GLRA3_HUMAN",
        "mass": 53800.0,
        "length": 464,
        "protein_name": "Glycine receptor subunit alpha-3",
        "gene_name": "GLRA3",
        "organism": "Human",
        "refseq_name": "glycine receptor subunit alpha-3 isoform b precursor",
        "refseq_ac": "NP_001036008",
        "gene_names_uniprotkb": "GLRA3",
        "gene_names_refseq": "GLRA3",
        "protein_names_uniprotkb": "Glycine receptor subunit alpha-3",
        "protein_names_refseq": "glycine receptor subunit alpha-3 isoform b precursor; glycine receptor subunit alpha-3; glycine receptor, alpha-3 polypeptide; ligand gated ion channel",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8001);  (R-HSA-112314)",
        "pathway_count": 2,
        "publication_count": 36,
        "publication_id_list": "11485506;11496371;12532186;1387926;16116092;16389408;17392525;17652911;18761359;19086053;19664994;20844345;21180598;2155780;22993341;25323946;25333367;25949526;26238288;26416729;28291778;28832583;28834231;28883437;29763014;29774051;29947514;30120300;38253038;7507039;7565620;7691500;7894176;8717357;9677400;9950429",
        "class_list": "",
        "function": "Determines location of mouse glycine alpha 3., [RefSeq, PubMed]; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:26416729, PubMed:9677400). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; In this study, the association between the common rs10011025 variant in the GLRA3 locus, and albuminuria, was confirmed in 1259 independent Finnish individuals with type 1 diabetes (p = 0.0013), and meta-analysis of all Finnish individuals yielded a genome-wide significant association. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; This gene encodes a member of the ligand-gated ion channel protein family. The encoded protein is a member of the glycine receptor subfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]., [RefSeq]; This study explores the roles of Tyr and Trp residues in the extracellular domains of the glycine receptor alpha 3 and shows that four such residues that have not been previously studied (Y24, Y58, W170, and Y197) contribute significantly to the function of the protein., [RefSeq, PubMed]; Using quantitative photoactivated localisation microscopy the authors found that alpha-1 and alpha-3 containing glycine receptors display the same alpha3:beta2 stoichiometry and gephyrin binding. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DP44;O75816;Q5D0E3",
        "ec_number_list": "1.8.-.-;1.8.5.1;1.11.1.-;5.6.1.6",
        "go_molecular_function": "GO:0016934 extracellularly glycine-gated chloride channel activity;GO:0022852 glycine-gated chloride ion channel activity;GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0016594 glycine binding",
        "go_cellular_component": "GO:0016935 glycine-gated chloride channel complex;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0045211 postsynaptic membrane",
        "go_biological_process": "GO:0051260 protein homooligomerization;GO:1902476 chloride transmembrane transport;GO:0099171 presynaptic modulation of chemical synaptic transmission",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "O75311-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75487-1",
        "uniprot_id": "GPC4_HUMAN",
        "mass": 62412.0,
        "length": 556,
        "protein_name": "Glypican-4",
        "gene_name": "GPC4",
        "organism": "Human",
        "refseq_name": "glypican-4 precursor",
        "refseq_ac": "NP_001439",
        "gene_names_uniprotkb": "GPC4; PRO937",
        "gene_names_refseq": "GPC4; K-glypican; KPTS",
        "protein_names_uniprotkb": "Glypican-4; K-glypican",
        "protein_names_refseq": "dJ900E8.1 (glypican 4); glypican proteoglycan 4; glypican-4 precursor",
        "tax_id": 9606,
        "disease": "Keipert syndrome (Disease Ontology:DOID:0111842)",
        "pathway": " (hsa:2239);  (R-HSA-1971475);  (R-HSA-2022928);  (R-HSA-2024096);  (R-HSA-3560783);  (R-HSA-3560801);  (R-HSA-3656237);  (R-HSA-3656253);  (R-HSA-4420332);  (R-HSA-9694614);  (R-HSA-975634);  (R-HSA-9769735);  (R-HSA-9769739);  (R-HSA-9820960);  (R-HSA-9833110);  (R-HSA-9918481);  (R-HSA-9918485)",
        "pathway_count": 17,
        "publication_count": 312,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10026158;10052934;10318803;10446189;10466419;10473568;10480354;10506123;10639137;10644753;10677367;10716625;10769148;10814714;10842173;11027606;11035113;11060341;11087757;11099377;11169766;11181758;11238108;11274177;11274389;11279150;11337487;11390981;11391482;11477410;11551958;11607032;11747608;11833835;11877387;12052963;12138164;12213822;12441129;12492399;12522689;12682107;1279089;12907439;12927802;12975309;14519844;14762106;14976261;14982929;14993226;15010527;15082721;15084397;15098107;15140961;15163706;15211654;15294915;15358783;1542003;15461586;15474033;15507651;15583000;15607426;15647514;15838506;16151907;16161994;1618828;16200213;16343444;16619025;16939223;16960811;16962401;17033958;17194707;17506785;17525477;17598008;17635713;17644776;17697703;18087047;18266465;18295589;18420935;18460466;18507396;1856611;1874730;19014918;1902833;19139408;19297154;1930190;19344451;1946389;19473117;2040636;20410276;20427285;20554947;20560209;20560210;20576607;20650889;20691685;21068237;21106934;2122463;21325420;21406692;21700882;21763480;21851338;21911577;21932952;22090124;22144186;2248955;22496216;22618708;22652793;2271516;22786881;22810237;22816037;23006890;23084921;23105391;23584533;23621622;23656592;23658209;23664117;23664118;23683607;2384594;24074594;24106281;24227843;24425863;24443026;24554904;24715725;25135637;2538457;25502872;25521717;25713144;25813380;25854864;25855704;26056282;26092250;26212330;26311884;26468529;26953343;26992070;2704749;27108190;271951;27277342;27550352;27832191;2793848;28132690;28148688;28218747;28467828;29242379;29276006;29314611;29393594;29419409;29427996;29437578;29557506;29610346;29632046;29742433;29786170;29902443;30429286;30459171;30471091;3052293;30599162;30918026;30982611;31003762;31020640;31262782;31439947;31720911;32125455;32142651;32157095;32179150;32350084;32362314;32387766;32512386;32532959;32653452;32703818;3275472;32970989;32983136;32995803;33082293;33082294;33159882;33177556;33298900;33392160;33493182;33493263;33494095;33554856;33592498;33717175;33774649;33936100;34023935;34078123;34159616;34179075;34235261;34235568;34324210;34357683;34431042;34433824;34510494;34542788;34561887;34611326;34732583;34782609;34929169;34932366;35051231;35154160;35215846;3527261;35343766;35676258;36010968;36102648;36284347;36951953;3714052;3744129;37511353;37726033;37844682;37925034;38424123;3863104;3942763;4345202;4708024;5057882;5675424;6323392;6420172;6496574;6961410;6980899;7493035;7499257;7550340;7601448;7683668;7711731;8017323;8144529;8384721;8578528;8598903;8639673;8639781;8728311;8776591;8782816;8894688;8981950;9218519;9285796;9326317;9346953;9459334;9463333;9469622;9506957;9535912;9620772;9787072;9888420;9892646;9915799;9920938;9925661;9931503;9988767",
        "class_list": "glycogene",
        "function": "Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage.  These proteins may play a role in the control of cell division and growth regulation.  The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]., [RefSeq]; Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity)., [UniProtKB]; Circulating glypican-4 is a new predictor of all-cause mortality in patients with heart failure., [RefSeq, PubMed]; Glypican-4 serum levels are associated with cognitive dysfunction and vascular risk factors in Parkinson's disease. Publication Status: Online-Only, [RefSeq, PubMed]; The Shear Stress-Regulated Expression of Glypican-4 in Endothelial Dysfunction In Vitro and Its Clinical Significance in Atherosclerosis. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 8,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 8,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 8,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 513,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 1,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6J7;B4E2C0;Q6ZMA6;Q96L43;Q9NU08;Q9UJN1;Q9UPD9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0015026 coreceptor activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005796 Golgi lumen;GO:0005886 plasma membrane;GO:0009986 cell surface",
        "go_biological_process": "GO:0016477 cell migration;GO:0016055 Wnt signaling pathway;GO:0009966 regulation of signal transduction;GO:0099560 synaptic membrane adhesion;GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 32.5,
        "record_id": "O75487-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P07203-1",
        "uniprot_id": "GPX1_HUMAN",
        "mass": 22088.0,
        "length": 203,
        "protein_name": "Glutathione peroxidase 1",
        "gene_name": "GPX1",
        "organism": "Human",
        "refseq_name": "glutathione peroxidase 1 isoform 1",
        "refseq_ac": "NP_000572",
        "gene_names_uniprotkb": "GPX1",
        "gene_names_refseq": "GPX1; GPXD; GSHPX1",
        "protein_names_uniprotkb": "Glutathione peroxidase 1; 1.11.1.12; 1.11.1.9; Cellular glutathione peroxidase; GPx-1; GSHPx-1; Phospholipid-hydroperoxide glutathione peroxidase GPX1",
        "protein_names_refseq": "GSHPx-1; cellular glutathione peroxidase; glutathione peroxidase 1 isoform 1; phospholipid-hydroperoxide glutathione peroxidase GPX1; selenoprotein GPX1",
        "tax_id": 9606,
        "disease": "Keshan disease (Disease Ontology:DOID:0050083); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); myeloid neoplasm (Disease Ontology:DOID:0070004); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); alpha thalassemia (Disease Ontology:DOID:1099); diabetic angiopathy (Disease Ontology:DOID:11713); gestational diabetes (Disease Ontology:DOID:11714); iron deficiency anemia (Disease Ontology:DOID:11758); nephrotic syndrome (Disease Ontology:DOID:1184); leukemia (Disease Ontology:DOID:1240); Huntington's disease (Disease Ontology:DOID:12858); cardiovascular system disease (Disease Ontology:DOID:1287); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); hypothyroidism (Disease Ontology:DOID:1459); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); calcinosis (Disease Ontology:DOID:182); colon cancer (Disease Ontology:DOID:219); anemia (Disease Ontology:DOID:2355); nephrosis (Disease Ontology:DOID:2527); larynx cancer (Disease Ontology:DOID:2596); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); hairy cell leukemia (Disease Ontology:DOID:285); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); coronary artery disease (Disease Ontology:DOID:3393); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic kidney disease (Disease Ontology:DOID:784); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); vascular dementia (Disease Ontology:DOID:8725); Crohn's disease (Disease Ontology:DOID:8778); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); hyperhomocysteinemia (Disease Ontology:DOID:9279); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:2876);  (R-HSA-2142688);  (R-HSA-2142712);  (R-HSA-2142770);  (R-HSA-3299685)",
        "pathway_count": 5,
        "publication_count": 193,
        "publication_id_list": "10029572;10220143;10514471;10521424;10549853;10656833;10692117;10807784;10833429;10919671;10982;11018045;11115402;11139407;11237011;11466336;11507097;11518528;11839751;11886899;11912930;12446202;12496980;12829378;12881489;12893824;14744747;15044467;15046979;15064408;15247771;15280035;15317809;15331559;1556108;15596429;15629692;15772423;15927447;16401067;16615992;1662607;1668270;16750198;16880213;17074750;17275676;17519234;17548672;1763037;17662651;17707404;18298806;18358825;18570379;18703498;18936159;19082953;19219623;19542232;19944066;1999334;20070187;20367259;20690882;2071038;21215271;21385867;21393238;21558561;21967640;2217179;22424782;22493009;22869735;22910329;2307470;23152058;23164639;2318885;23454490;23455484;23481700;2377602;24275569;24715725;2501828;25047527;25576301;25576336;25645385;26154972;26370990;26811146;26992070;27543614;27862975;28514659;28832583;28904123;29242379;29331515;29393594;29437277;2955287;29557506;29786170;3006030;30315122;30410026;30429286;30484775;30524438;30573663;30779550;30833945;31154438;3118366;31217245;31222486;3164719;31844035;31844290;31848261;31937595;31998317;32157095;32161166;32162841;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33043033;33091337;33123756;33141586;33298915;33392160;33592498;33691108;33912179;33936100;33968037;33981976;34171305;34211107;34357683;34509645;3457020;35051231;35318648;3532102;35561310;35580925;36010968;3619451;36215666;36241641;3658677;36608588;3693360;3697069;37390459;37405601;37572455;37938771;38809917;5389100;60;6286671;6816802;6961438;7021796;7172448;7487923;7568157;807573;8334154;8379940;8428933;8452552;8663465;9295278;9369223;9618483;9639555;9726962;9923614",
        "class_list": "",
        "function": "Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis. Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides. In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Cellular and exosomal GPx1 are essential for controlling hydrogen peroxide balance and alleviating oxidative stress in hypoxic glioblastoma., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3., [RefSeq, PubMed]; The mRNA expression of genes encoding selected antioxidant enzymes and thioredoxin, and the concentrations of their protein products in gingival crevicular fluid and saliva during periodontitis., [RefSeq, PubMed]; The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. Alternatively spliced transcript variants have been found for this gene. Pseudogenes of this locus have been identified on chromosomes X and 21. [provided by RefSeq, Aug 2017]., [RefSeq]; Variation of the genes encoding antioxidant enzymes SOD2 (rs4880), GPX1 (rs1050450), and CAT (rs1001179) and susceptibility to male infertility: a genetic association study and in silico analysis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "diagnostic",
        "glycan_count": 1,
        "disease_count": 50,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PAS1;Q7Z5H1;Q9BW12",
        "ec_number_list": "1.11.1.-;5.3.99.3;2.5.1.18;4.4.1.20;2.5.1.-;1.8.-.-;1.11.1.9;1.11.1.27;1.16.3.1;1.16.3.4;1.11.1.12;5.3.3.-;5.3.4.1",
        "go_molecular_function": "GO:0017124 SH3 domain binding;GO:1990782 protein tyrosine kinase binding;GO:0004602 glutathione peroxidase activity;GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity;GO:0004601 peroxidase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol",
        "go_biological_process": "GO:1902905 positive regulation of supramolecular fiber organization;GO:0035094 response to nicotine;GO:0071333 cellular response to glucose stimulus;GO:0060047 heart contraction;GO:0042542 response to hydrogen peroxide",
        "synthesized_glycan_count": 0,
        "hit_score": 19.6,
        "record_id": "P07203-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P09210-1",
        "uniprot_id": "GSTA2_HUMAN",
        "mass": 25664.0,
        "length": 222,
        "protein_name": "Glutathione S-transferase A2",
        "gene_name": "GSTA2",
        "organism": "Human",
        "refseq_name": "glutathione S-transferase A2",
        "refseq_ac": "NP_000837",
        "gene_names_uniprotkb": "GSTA2; GST2",
        "gene_names_refseq": "GST2; GSTA2-2; GSTA2; GTA2; GTH2",
        "protein_names_uniprotkb": "Glutathione S-transferase A2; 2.5.1.18; GST HA subunit 2; GST class-alpha member 2; GST-gamma; GSTA2-2; GTH2",
        "protein_names_refseq": "GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-(hydroxyalkyl)glutathione lyase A2; glutathione S-alkyltransferase A2; glutathione S-aralkyltransferase A2; glutathione S-aryltransferase A2; glutathione S-transferase A2; liver GST2; testis tissue sperm-binding protein Li 59n",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2939);  (R-HSA-156590);  (R-HSA-8950505);  (R-HSA-9748787)",
        "pathway_count": 4,
        "publication_count": 72,
        "publication_id_list": "10329152;10587441;10783391;10840050;11327815;11668220;11904223;12042665;12211029;12435799;12627223;12697733;1329668;14742434;1497629;15747503;15850391;16038020;16081649;16298388;16530731;16548513;16717136;17301077;17377532;17996297;197968;20083122;20085333;20216118;21106529;211390;21668448;21723252;22444596;22522127;23096567;23162467;23816837;24824603;24974183;2604726;26238318;26374642;27862975;29482072;29557506;3036131;30987408;31844290;3372534;35580925;3770744;4768551;5767308;657528;6989049;7892174;8182750;8203914;8226881;8331657;8431482;8670112;8703034;8812420;9099726;9132023;9278457;942489;9551553;9839448",
        "class_list": "",
        "function": "Catalyzes the conjugation of glutathione to a large variety of electrophilic compounds., [UniProtKB, UniProtKB]; Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q12759;Q16491;Q9NTY6",
        "ec_number_list": "2.5.1.18;5.2.1.2;5.3.99.2;1.11.1.-;5.3.3.-;1.20.4.2;1.8.5.1;4.4.1.20",
        "go_molecular_function": "GO:0004364 glutathione transferase activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0006805 xenobiotic metabolic process;GO:0006749 glutathione metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "P09210-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P14770-1",
        "uniprot_id": "GPIX_HUMAN",
        "mass": 19046.0,
        "length": 177,
        "protein_name": "Platelet glycoprotein IX",
        "gene_name": "GP9",
        "organism": "Human",
        "refseq_name": "platelet glycoprotein IX precursor",
        "refseq_ac": "NP_000165",
        "gene_names_uniprotkb": "GP9",
        "gene_names_refseq": "CD42a; GP9; GPIX",
        "protein_names_uniprotkb": "Platelet glycoprotein IX; GP-IX; GPIX; Glycoprotein 9",
        "protein_names_refseq": "glycoprotein 9; platelet glycoprotein IX precursor",
        "tax_id": 9606,
        "disease": "Bernard-Soulier syndrome (Disease Ontology:DOID:2217)",
        "pathway": " (hsa:2815);  (R-HSA-430116);  (R-HSA-75892);  (R-HSA-76009);  (R-HSA-9673221);  (R-HSA-9769739);  (R-HSA-9769743);  (R-HSA-9845620);  (R-HSA-9846298);  (R-HSA-9935598)",
        "pathway_count": 10,
        "publication_count": 132,
        "publication_id_list": "10026158;10583255;10627461;10807784;10887121;11035113;11167791;11238108;11342438;11700320;11758225;11833835;11943772;12052963;12100158;12665801;12855811;12907439;12944405;14521605;14982929;16102041;16102042;16161994;1618828;16619025;17506785;17598008;17635713;1902833;19297154;1930190;1939645;1998667;20004170;2010539;2019570;20427285;2052556;2104832;2110473;21107324;2162822;21932952;22144186;2253772;22618708;2271516;22786881;22961984;23021219;23683607;2384594;24554904;2502206;2505252;2538457;25713144;25855704;2592373;26154972;26473492;2713493;2738071;2752109;2771955;2775660;2788012;28561420;28603902;29223926;29419409;29557506;29632711;3009023;3017409;3056407;3082357;30918026;31262782;3129422;3134349;31439947;3155520;33397811;33550613;3524673;35580925;36215666;36951953;3733688;3744129;37726033;37938771;3863104;3872140;588558;6323392;6334516;6438527;7499257;7517401;7727775;7756647;7935795;8034572;8144529;8148489;8338946;8384898;8429020;8463288;8481514;8626656;8631758;8639781;893417;9163595;9169594;9184424;9218519;9226169;9280292;9331419;9425086;9459334;9469622;9607108;9774404;9834200;9886312;9888880",
        "class_list": "",
        "function": "Case Report: suggest that alloantibodies directed against Cab4b, the first human platelet antigen carried by glycoprotein IX, can induce severe neonatal thrombocytopenia., [RefSeq, PubMed]; ERK5 associates with CKII to play essential roles in GPIb-IX-mediated platelet activation via the PTEN/PI3K/Akt pathway., [RefSeq, PubMed]; Oxidation shuts down an auto-inhibitory mechanism of von Willebrand factor., [RefSeq, PubMed]; The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib., [UniProtKB]; This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. [provided by RefSeq, Oct 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14445;Q8N1D1;Q92525",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0007597 blood coagulation, intrinsic pathway;GO:0007596 blood coagulation;GO:0051209 release of sequestered calcium ion into cytosol;GO:0035855 megakaryocyte development",
        "synthesized_glycan_count": 0,
        "hit_score": 13.3,
        "record_id": "P14770-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P21695-1",
        "uniprot_id": "GPDA_HUMAN",
        "mass": 37568.0,
        "length": 349,
        "protein_name": "Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic",
        "gene_name": "GPD1",
        "organism": "Human",
        "refseq_name": "glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform 2",
        "refseq_ac": "NP_001244128",
        "gene_names_uniprotkb": "GPD1",
        "gene_names_refseq": "GPD-C; GPD1; GPDH-C; HTGTI",
        "protein_names_uniprotkb": "Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic; 1.1.1.8; GPD-C; GPDH-C",
        "protein_names_refseq": "epididymis secretory sperm binding protein; glycerol-3-phosphate dehydrogenase 1 (soluble); glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform 2; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic; glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic; glycerophosphate dehydrogenase",
        "tax_id": 9606,
        "disease": "transient infantile hypertriglyceridemia and hepatosteatosis (MONDO:MONDO:0013771)",
        "pathway": " (hsa:2819);  (R-HSA-1483166)",
        "pathway_count": 2,
        "publication_count": 64,
        "publication_id_list": "10455175;10506173;10553003;10681567;11031251;11112443;11237011;11788596;11830583;12063250;12161451;12359733;12522102;12963729;14573790;15367102;16460752;16495223;16620771;16704971;16864775;17028579;17170135;17707131;18238778;18718904;19336658;19666841;20705608;21173190;22226083;22777291;22922100;23176821;23176823;23481700;23807634;2398890;24275569;24549054;24715725;24966474;26711011;2925608;29557506;31844290;32387766;34098990;3458202;34657876;36632231;38689091;7060561;7772607;7821823;8163052;8186247;8300559;8530346;8687421;9188469;9212163;9461603;9582313",
        "class_list": "",
        "function": "A HIF1alpha-GPD1 feedforward loop inhibits the progression of renal clear cell carcinoma via mitochondrial function and lipid metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; Decreased serum levels of glycerol-3- phosphate dehydrogenase 1 and monoacylglycerol lipase act as diagnostic biomarkers for breast cancer., [RefSeq, PubMed]; Glycerol 3-phosphate dehydrogenases (1 and 2) in cancer and other diseases. Review article, [RefSeq, PubMed]; Has glycerol-3-phosphate dehydrogenase activity., [UniProtKB, PubMed]; Mutation analysis revealed a homozygous splicing mutation, c.361-1G>C, which resulted in an aberrantly spliced mRNA in the ten affected individuals., [RefSeq, PubMed]; Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression. Publication Status: Online-Only, [RefSeq, PubMed]; The apoenzyme structure of GPD1 has been determined; an electrophilic catalytic mechanism by the epsilon-NH3+ group of Lys204 is proposed on the basis of structural analyses., [RefSeq, PubMed]; This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F8W1L5;Q8N1B0",
        "ec_number_list": "1.1.1.8",
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051287 NAD binding;GO:0047952 glycerol-3-phosphate dehydrogenase [NAD(P)+] activity;GO:0141152 glycerol-3-phosphate dehydrogenase (NAD+) activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006072 glycerol-3-phosphate metabolic process;GO:0046168 glycerol-3-phosphate catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "P21695-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P23415-1",
        "uniprot_id": "GLRA1_HUMAN",
        "mass": 52624.0,
        "length": 457,
        "protein_name": "Glycine receptor subunit alpha-1",
        "gene_name": "GLRA1",
        "organism": "Human",
        "refseq_name": "glycine receptor subunit alpha-1 isoform 2 precursor",
        "refseq_ac": "NP_000162",
        "gene_names_uniprotkb": "GLRA1",
        "gene_names_refseq": "GLRA1; HKPX1; STHE",
        "protein_names_uniprotkb": "Glycine receptor subunit alpha-1; Glycine receptor 48 kDa subunit; Glycine receptor strychnine-binding subunit",
        "protein_names_refseq": "glycine receptor 48 kDa subunit; glycine receptor strychnine-binding subunit; glycine receptor subunit alpha-1 isoform 2 precursor; glycine receptor subunit alpha-1",
        "tax_id": 9606,
        "disease": "hyperekplexia (Disease Ontology:DOID:0060695); hyperekplexia 1 (Disease Ontology:DOID:0060696)",
        "pathway": " (hsa:2741);  (R-HSA-112314)",
        "pathway_count": 2,
        "publication_count": 59,
        "publication_id_list": "10514101;11237011;11485506;12532186;12667090;1387926;14551753;15952785;16116092;16144831;16389408;17392525;17652911;18761359;19861413;20844345;21180598;2155780;22715885;22973015;22993341;23994010;24108130;25323946;25333367;25445488;25730860;25949526;25973519;26238288;26992070;28291778;29557506;29763014;29774051;32354853;32445491;32938616;35526563;36434917;37821459;39146932;7507039;7565620;7611730;7691500;7881416;7920629;7925268;7981700;8298642;8571969;8717357;8733061;9009272;9067762;9677400;9920650;9950429",
        "class_list": "",
        "function": "A Novel Glycine Receptor Variant with Startle Disease Affects Syndapin I and Glycinergic Inhibition., [RefSeq, PubMed]; Four Turkish families with hyperekplexia: A missense mutation and the exon 1-7 deletion in the GLRA1 gene., [RefSeq, PubMed]; Gating mechanism of the human alpha1beta GlyR by glycine., [RefSeq, PubMed]; Subunit of heteromeric glycine-gated chloride channels (PubMed:14551753, PubMed:23994010, PubMed:25730860, PubMed:37821459). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Channel activity is potentiated by ethanol (PubMed:25973519). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found. [provided by RefSeq, Dec 2015]., [RefSeq]; The startle disease mutation alpha1S270T predicts shortening of glycinergic synaptic currents., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6T3;Q14C77;Q6DJV9",
        "ec_number_list": "1.8.-.-;1.8.5.1;1.11.1.-;5.6.1.6",
        "go_molecular_function": "GO:0016934 extracellularly glycine-gated chloride channel activity;GO:0030977 taurine binding;GO:0004888 transmembrane signaling receptor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043204 perikaryon",
        "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0001964 startle response;GO:0051970 negative regulation of transmission of nerve impulse;GO:0060012 synaptic transmission, glycinergic;GO:0097305 response to alcohol",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "P23415-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P23416-1",
        "uniprot_id": "GLRA2_HUMAN",
        "mass": 52002.0,
        "length": 452,
        "protein_name": "Glycine receptor subunit alpha-2",
        "gene_name": "GLRA2",
        "organism": "Human",
        "refseq_name": "glycine receptor subunit alpha-2 isoform A precursor",
        "refseq_ac": "NP_001112357",
        "gene_names_uniprotkb": "GLRA2",
        "gene_names_refseq": "GLRA2; GLR; MRXSP",
        "protein_names_uniprotkb": "Glycine receptor subunit alpha-2",
        "protein_names_refseq": "glycine receptor alpha 2 subunit; glycine receptor subunit alpha-2 isoform A precursor; glycine receptor subunit alpha-2; glycine receptor, alpha-2 polypeptide",
        "tax_id": 9606,
        "disease": "syndromic X-linked intellectual disability Pilorge type (Disease Ontology:DOID:0070422)",
        "pathway": " (hsa:2742);  (R-HSA-112314)",
        "pathway_count": 2,
        "publication_count": 48,
        "publication_id_list": "11237011;11485506;12532186;1387926;15147510;15302677;16116092;16144831;16389408;17392525;17652911;18761359;20479760;20844345;21180598;2155780;21740066;22606311;22993341;23895467;25323946;25333367;25445488;25949526;26238288;26370147;27382060;28291778;28588452;29557506;29632711;29763014;29774051;33592498;34473954;34561969;35051231;35294868;35396272;35494241;7507039;7565620;7691500;8717357;8973915;9674912;9677400;9950429",
        "class_list": "",
        "function": "Data show that the current-voltage relationships of homomeric channels formed by the alpha2 or alpha3 subunits change upon receptor desensitization from a linear to an inwardly rectifying shape, in contrast to their heteromeric counterparts., [RefSeq, PubMed]; Effects of 12 times normal atmospheric pressure of helium-oxygen gas (pressure) on ethanol-induced potentiation of GlyR function in Xenopus oocytes expressing human alpha1, alpha2 or the mutant alpha1(A52S) GlyRs were measured by voltage clamp technics, [RefSeq, PubMed]; GLRA2 gene mutations cause high myopia in humans and mice., [RefSeq, PubMed]; Investigated neural progenitor cells in respect to their glycine receptor function and subunit expression using electrophysiology, calcium imaging, immunocytochemistry, and quantitative real-time PCR, [RefSeq, PubMed]; Subunit of heteromeric glycine-gated chloride channels (PubMed:15302677, PubMed:16144831, PubMed:2155780, PubMed:23895467, PubMed:25445488, PubMed:26370147, PubMed:34473954). Plays a role in synaptic plasticity (By similarity). Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down-regulation of neuronal excitability (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K0J6;B2R6I8;B7Z4F5;J3KQ59;Q53YX7;Q6ICQ0;Q99862",
        "ec_number_list": "1.8.-.-;1.8.5.1;1.11.1.-;5.6.1.6",
        "go_molecular_function": "GO:0016934 extracellularly glycine-gated chloride channel activity;GO:0022852 glycine-gated chloride ion channel activity;GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0016594 glycine binding",
        "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0034707 chloride channel complex;GO:0042995 cell projection;GO:0098690 glycinergic synapse",
        "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0034220 monoatomic ion transmembrane transport;GO:0071361 cellular response to ethanol;GO:0050804 modulation of chemical synaptic transmission;GO:1902476 chloride transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "P23416-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P30968-1",
        "uniprot_id": "GNRHR_HUMAN",
        "mass": 37731.0,
        "length": 328,
        "protein_name": "Gonadotropin-releasing hormone receptor",
        "gene_name": "GNRHR",
        "organism": "Human",
        "refseq_name": "gonadotropin-releasing hormone receptor isoform 1",
        "refseq_ac": "NP_000397",
        "gene_names_uniprotkb": "GNRHR; GRHR",
        "gene_names_refseq": "GNRHR1; GNRHR; GRHR; HH7; LHRHR; LRHR",
        "protein_names_uniprotkb": "Gonadotropin-releasing hormone receptor; GnRH receptor; GnRH-R",
        "protein_names_refseq": "gnRH receptor; gnRH-R; gonadotropin-releasing hormone (type 1) receptor 1; gonadotropin-releasing hormone receptor isoform 1; leutinizing hormone releasing horomone receptor; leutinizing-releasing hormone receptor; luliberin receptor; type I GnRH receptor",
        "tax_id": 9606,
        "disease": "primary sclerosing cholangitis (Disease Ontology:DOID:0060643); hypogonadotropic hypogonadism 7 with or without anosmia (Disease Ontology:DOID:0090078); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:2798);  (R-HSA-375281);  (R-HSA-416476)",
        "pathway_count": 3,
        "publication_count": 73,
        "publication_id_list": "10022417;10084584;10191087;10366411;10523035;10567430;10671200;10727532;10861009;11015615;11318785;11397842;11397871;11707068;11726197;11742120;11753430;11994356;12039074;12045258;12120503;12679486;1333190;15951850;16182515;16268778;16339447;16754659;16923326;1709010;17095587;18434541;18515384;18577758;18936096;19006286;1905813;1922095;21657270;2244890;23643382;25077900;2558651;25811175;26398856;26774084;2841328;3086311;34297503;34807394;35051231;35264044;35777983;36035370;37828510;38194289;6090951;7534732;7649152;7768323;7937899;8188646;8386108;8664309;8702611;9259321;9272108;9300077;9305846;9371856;9419371;9425890;9770463",
        "class_list": "",
        "function": "AXL receptor tyrosine kinase modulates gonadotropin-releasing hormone receptor signaling. Publication Status: Online-Only, [RefSeq, PubMed]; GnRH receptor mediates lipid storage in female adipocytes via AMPK pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Gonadotropin-releasing hormone receptor inhibits triple-negative breast cancer proliferation and metastasis., [RefSeq, PubMed]; Immunohistochemical Expression of LHRH Receptor in Different Compartments of Female Genital Tract in Patients With Endometrial Cancer., [RefSeq, PubMed]; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling., [UniProtKB]; Reports complete structure of human gonadotropin-releasing hormone receptor gene with figure 2 showing multiple promoters, transcription sites, and polyadenylation signals., [RefSeq, PubMed]; This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; [Clinical and molecular genetic features of cases of isolated hypogonadotropic hypogonadism, associated with defects in GNRHR genes]. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75793;Q14D13;Q92644",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004968 gonadotropin-releasing hormone receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0032274 gonadotropin secretion;GO:0007186 G protein-coupled receptor signaling pathway;GO:0032870 cellular response to hormone stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 7.4,
        "record_id": "P30968-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P32189-3",
        "uniprot_id": "GLPK_HUMAN",
        "mass": 61245.0,
        "length": 559,
        "protein_name": "Glycerol kinase",
        "gene_name": "GK",
        "organism": "Human",
        "refseq_name": "glycerol kinase isoform b",
        "refseq_ac": "NP_000158",
        "gene_names_uniprotkb": "GK",
        "gene_names_refseq": "GK1; GKD; GK",
        "protein_names_uniprotkb": "Glycerol kinase; 2.7.1.30; ATP:glycerol 3-phosphotransferase; Glycerokinase",
        "protein_names_refseq": "ATP:glycerol 3-phosphotransferase; glycerokinase; glycerol kinase isoform b",
        "tax_id": 9606,
        "disease": "glycerol kinase deficiency (Disease Ontology:DOID:0060363); familial hypercholesterolemia (Disease Ontology:DOID:13810)",
        "pathway": " (hsa:2710);  (R-HSA-75109)",
        "pathway_count": 2,
        "publication_count": 56,
        "publication_id_list": "10736265;10851254;11481335;11672446;12618427;12824082;14521909;14970677;15845384;17158099;18238778;18694939;18718904;19336658;20643956;24714562;25838202;25880248;26992070;27600516;27862975;27920218;28514659;28832583;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29786170;30410026;31844290;32157095;32387766;32897882;32938616;32983136;33298915;33592498;33717175;33912179;34405274;34509645;35051231;36010968;37021775;37340703;38365953;7987308;8401584;8499898;8499912;8651297;9719371",
        "class_list": "",
        "function": "Expression and characterisation of human glycerol kinase: the role of solubilising agents and molecular chaperones. Erratum:[Biosci Rep. 2023 Oct 31;43(10):BSR-2022-2258_COR. doi: 10.1042/BSR-2022-2258_COR. PMID: 37860917], [RefSeq, PubMed]; Glycerol kinase enzyme is a prognostic predictor in esophageal carcinoma and is associated with immune cell infiltration. Publication Status: Online-Only, [RefSeq, PubMed]; Kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Sn-glycerol 3-phosphate is a crucial intermediate in various metabolic pathways, such as the synthesis of glycerolipids and triglycerides, glycogenesis, glycolysis and gluconeogenesis., [UniProtKB, PubMed, PubMed]; The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NJP5;B2R833;Q6IQ27;Q8IVR5;Q9UMP0;Q9UMP1",
        "ec_number_list": "2.7.1.30",
        "go_molecular_function": "GO:0004370 glycerol kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0046167 glycerol-3-phosphate biosynthetic process;GO:0006641 triglyceride metabolic process;GO:0019432 triglyceride biosynthetic process;GO:0006071 glycerol metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "P32189-3",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P35754-1",
        "uniprot_id": "GLRX1_HUMAN",
        "mass": 11776.0,
        "length": 106,
        "protein_name": "Glutaredoxin-1",
        "gene_name": "GLRX",
        "organism": "Human",
        "refseq_name": "glutaredoxin-1",
        "refseq_ac": "NP_001112362",
        "gene_names_uniprotkb": "GLRX; GRX",
        "gene_names_refseq": "GLRX; GRX1; GRX",
        "protein_names_uniprotkb": "Glutaredoxin-1; TTase-1; Thioltransferase-1",
        "protein_names_refseq": "TTase-1; glutaredoxin-1; thioltransferase-1",
        "tax_id": 9606,
        "disease": "Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:2745);  (R-HSA-499943)",
        "pathway_count": 2,
        "publication_count": 82,
        "publication_id_list": "10215863;10453732;10618642;10716435;10799505;10884394;10899599;11222536;11277919;11278511;11517226;11796141;11912132;12972261;13211603;14729598;15630091;16179339;16373698;16756507;16820675;17320107;177353;17824959;17975675;18469;1851158;18635542;18997010;19176520;19220460;19766732;21080915;211388;211390;22847445;23416111;2542324;26375851;2656695;2668278;26992070;27726376;28467828;29242379;29314611;29351928;29393594;29557506;30833945;31154438;31222486;32983136;33043033;33329553;33359085;33392160;33592498;34078123;34357683;34587543;35154160;35714567;36215666;37507364;38665916;40596516;40615;5484814;6182143;6248551;7685356;7851394;8018729;8019414;8448179;8645179;8663313;9332366;9488696;9677297;9860827",
        "class_list": "",
        "function": "Cellular S-denitrosylases: Potential role and interplay of Thioredoxin, TRP14, and Glutaredoxin systems in thiol-dependent protein denitrosylation. Review article, [RefSeq, PubMed]; Cytosolic glutaredoxin 1 is upregulated in AMD and controls retinal pigment epithelial cells proliferation via beta-catenin., [RefSeq, PubMed]; Glutaredoxin-1 levels in plasma can predict future events in patients with cardiovascular diseases., [RefSeq, PubMed]; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins., [UniProtKB]; Redox Regulator GLRX Is Associated With Tumor Immunity in Glioma. Publication Status: Online-Only, [RefSeq, PubMed]; Structural and functional fine mapping of cysteines in mammalian glutaredoxin reveal their differential oxidation susceptibility. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R4L2;Q3KQS1;Q6ICT1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0015038 glutathione disulfide oxidoreductase activity;GO:0017080 sodium channel regulator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0015949 nucleobase-containing small molecule interconversion;GO:0045838 positive regulation of membrane potential",
        "synthesized_glycan_count": 0,
        "hit_score": 8.6,
        "record_id": "P35754-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P36915-1",
        "uniprot_id": "GNL1_HUMAN",
        "mass": 68661.0,
        "length": 607,
        "protein_name": "Guanine nucleotide-binding protein-like 1",
        "gene_name": "GNL1",
        "organism": "Human",
        "refseq_name": "guanine nucleotide-binding protein-like 1",
        "refseq_ac": "NP_005266",
        "gene_names_uniprotkb": "GNL1; HSR1",
        "gene_names_refseq": "GNL1; HSR1",
        "protein_names_uniprotkb": "Guanine nucleotide-binding protein-like 1; GTP-binding protein HSR1",
        "protein_names_refseq": "G protein nucleolar 1 (putative); GTP-binding protein HSR1; HSR1 GTP-binding protein; guanine nucleotide-binding protein-like 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2794)",
        "pathway_count": 1,
        "publication_count": 50,
        "publication_id_list": "11237011;17081983;17525332;18452278;18669648;18707149;18767875;19651622;19690332;19851445;20068231;20166139;21406692;22244851;23186163;24275569;24908204;26154972;26811146;27862975;27920218;28218747;28228285;28832583;28904123;29242379;29437277;29557506;30061673;30192525;30379171;31844290;32350084;32502341;32938616;33147101;33214551;33912179;33968037;33981976;34019948;34171305;34229054;35051231;35251023;35561310;35580925;36010968;40914422;8180467",
        "class_list": "",
        "function": "Cross-talk between GNL1 and RPS20 is critical to promote cell proliferation. Publication Status: Online-Only, [RefSeq, PubMed]; Guanine nucleotide binding protein like-1 (GNL1) promotes cancer cell proliferation and survival through AKT/p21 (CIP1) signaling cascade., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Possible regulatory or functional link with the histocompatibility cluster., [UniProtKB, UniProtKB, UniProtKB]; The GNL1 gene, identified in the human major histocompatibility complex class I region, shows a high degree of similarity with its mouse counterpart. The GNL1 gene is located less than 2 kb centromeric to HLA-E, in the same transcriptional orientation. GNL1 is telomeric to HLA-B and HLA-C. [provided by RefSeq, Jul 2008]., [RefSeq]; The results demonstrated that multiple mechanisms are involved in the translocation of GNL1 to the nucleolus in a cell cycle-dependent manner to regulate cell growth and proliferation., [RefSeq, PubMed]; The results suggested that SNPs at PRR3 and ABCF1 genes and the haplotype composed by SNPs at GNL1 and PRR3 between the HLA-A and HLA-C genes tended to predict Graves ophthalmology in a gender-dependent manner in patients with Graves Disease in Taiwan., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0S838;Q96CT5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005198 structural molecule activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus",
        "go_biological_process": "GO:0007165 signal transduction;GO:0006974 DNA damage response;GO:0002456 T cell mediated immunity",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "P36915-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P40197-1",
        "uniprot_id": "GPV_HUMAN",
        "mass": 60959.0,
        "length": 560,
        "protein_name": "Platelet glycoprotein V",
        "gene_name": "GP5",
        "organism": "Human",
        "refseq_name": "platelet glycoprotein V precursor",
        "refseq_ac": "NP_004479",
        "gene_names_uniprotkb": "GP5",
        "gene_names_refseq": "CD42d; GP5; GPV",
        "protein_names_uniprotkb": "Platelet glycoprotein V; GPV; Glycoprotein 5",
        "protein_names_refseq": "glycoprotein 5; platelet glycoprotein V precursor; platelet glycoprotein V",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2814);  (R-HSA-430116);  (R-HSA-75892);  (R-HSA-76009);  (R-HSA-9673221);  (R-HSA-9769739);  (R-HSA-9769743);  (R-HSA-9845620);  (R-HSA-9846298);  (R-HSA-9935598)",
        "pathway_count": 10,
        "publication_count": 133,
        "publication_id_list": "10026158;10627461;10887121;11035113;11238108;11342438;11700320;11833835;11943772;12052963;12855811;12907439;12944405;14521605;14982929;16102041;16102042;16161994;1618828;16263699;16619025;17506785;17598008;17635713;17671839;1902833;19139490;19297154;1930190;19368777;1939645;19913121;1998667;20004170;2010539;2019570;20427285;2052556;20628086;2104832;2110473;21107324;21529934;2162822;21932952;22144186;22618708;2271516;22786881;22961984;23021219;23090970;2350580;23683607;2372284;2384594;23929303;24554904;2502206;2505252;2538457;25713144;25855704;2592373;26154972;26473492;2713493;2738071;2752109;2775660;27862975;2788012;28832583;29223926;29391424;29419409;29557506;3009023;3017409;3082357;30918026;31092671;31154438;31262782;3129422;3134349;31439947;3155520;32502341;33397811;34731616;35051231;3524673;35880886;36951953;3733688;3744129;37726033;3863104;3872140;588558;6323392;6334516;6438527;7499257;7517401;7690959;7727775;7756647;7935795;8034572;8144529;8148489;8338946;8384898;8407908;8463288;8626656;8631758;8639781;893417;9169594;9218519;9226169;9280292;9331419;9425086;9459334;9469622;9607108;9774404;9834200;9888880",
        "class_list": "",
        "function": "GP5 regulates epithelial-mesenchymal transition in breast cancer via the PI3K/AKT signaling pathway., [RefSeq, PubMed]; GPIIb/IIIa is the primary receptor set involved in platelet adhesion to adsorbed fibrinogen and serum albumin irrespective of their degree of adsorption-induced unfolding, while the GPIb-IX-V receptor complex plays an insignificant role., [RefSeq, PubMed]; Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010]., [RefSeq]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Studies indicate that platelets from Bernard-Soulier syndrome (BSS) are defective in glycoprotein (GP)Ib-IX-V, a platelet-specific adhesion-signaling complex, composed of GPIbalpha disulfide linked to GPIbbeta, and noncovalently associated with GPIX and GPV. Review article, [RefSeq, PubMed]; The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis., [UniProtKB]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 2,
        "mined_n_glycosites": 2,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 8593,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 0,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D1MER9",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:1990779 glycoprotein Ib-IX-V complex",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0007597 blood coagulation, intrinsic pathway;GO:0051209 release of sequestered calcium ion into cytosol;GO:0035855 megakaryocyte development;GO:0010572 positive regulation of platelet activation",
        "synthesized_glycan_count": 0,
        "hit_score": 14.3,
        "record_id": "P40197-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P41594-1",
        "uniprot_id": "GRM5_HUMAN",
        "mass": 132469.0,
        "length": 1212,
        "protein_name": "Metabotropic glutamate receptor 5",
        "gene_name": "GRM5",
        "organism": "Human",
        "refseq_name": "metabotropic glutamate receptor 5 isoform b precursor",
        "refseq_ac": "NP_000833",
        "gene_names_uniprotkb": "GRM5; GPRC1E; MGLUR5",
        "gene_names_refseq": "GPRC1E; GRM5; MGLUR5; PPP1R86; mGlu5",
        "protein_names_uniprotkb": "Metabotropic glutamate receptor 5; mGluR5",
        "protein_names_refseq": "glutamate receptor, metabotropic 5; metabotropic glutamate receptor 5 isoform b precursor; protein phosphatase 1, regulatory subunit 86",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); alcoholic neuropathy (Disease Ontology:DOID:14183); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); schizophrenia (Disease Ontology:DOID:5419); amphetamine abuse (Disease Ontology:DOID:670); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)",
        "pathway": " (hsa:2915);  (R-HSA-416476);  (R-HSA-420499);  (R-HSA-6794361)",
        "pathway_count": 4,
        "publication_count": 88,
        "publication_id_list": "10191087;10567430;10727532;10861009;11015615;11208605;11237011;11326300;11604393;11742120;11753430;11917125;12119301;12120503;1329206;15194188;15540461;15576628;15951850;16182515;16242404;16268778;16339447;16624946;16754659;16846852;16923326;17897391;18434541;18515384;18577758;18812509;18829961;18936096;1905813;19694902;20022913;20064387;20064388;20519524;20555319;21148030;21282647;23121374;23674604;24235081;25042998;25378172;27071541;28130356;2841328;28657654;29557506;29614098;3086311;31844290;31848261;33968037;35051231;35513511;38369690;38632403;38876317;39320043;7476890;7617140;7620613;7623957;7688218;7695896;7736595;7759551;7908515;7937899;8576240;8664309;8887960;9069287;9131252;9144337;9144651;9305846;9473604;9770463;9808458;9844003;9872316;9927700",
        "class_list": "",
        "function": "Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder., [RefSeq, PubMed]; G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity., [UniProtKB, PubMed, PubMed]; MGLUR5 and 1,4,5-InsP3 signaling control calcium release, [RefSeq, PubMed]; Metabotropic Glutamate Receptor 5 as a Potential Biomarker of the Intersection of Trauma and Cannabis Use., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Stepwise activation of a metabotropic glutamate receptor. Erratum:[Nature. 2024 May;629(8013):E13. doi: 10.1038/s41586-024-07470-5. PMID: 38702522], [RefSeq, PubMed]; This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]., [RefSeq]; Voltage tunes mGlu5 receptor function, impacting synaptic transmission., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 3,
        "reported_phosphosites": 3,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 54,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 9,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6J164",
        "ec_number_list": "",
        "go_molecular_function": "GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity;GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential;GO:0004930 G protein-coupled receptor activity;GO:0042802 identical protein binding;GO:0030296 protein tyrosine kinase activator activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body",
        "go_biological_process": "GO:1900452 regulation of long-term synaptic depression;GO:0035106 operant conditioning;GO:0007206 phospholipase C-activating G protein-coupled glutamate receptor signaling pathway;GO:1900039 positive regulation of cellular response to hypoxia;GO:0001659 temperature homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 10.0,
        "record_id": "P41594-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P46095-1",
        "uniprot_id": "GPR6_HUMAN",
        "mass": 37881.0,
        "length": 362,
        "protein_name": "G protein-coupled receptor 6",
        "gene_name": "GPR6",
        "organism": "Human",
        "refseq_name": "G-protein coupled receptor 6 isoform a",
        "refseq_ac": "NP_001273028",
        "gene_names_uniprotkb": "GPR6",
        "gene_names_refseq": "GPR6",
        "protein_names_uniprotkb": "G protein-coupled receptor 6; Sphingosine 1-phosphate receptor GPR6",
        "protein_names_refseq": "G-protein coupled receptor 6 isoform a; sphingosine 1-phosphate receptor GPR6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2830)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "12220620;12649592;19059244;19286662;20677014;22487033;29557506;32046081;32938616;39626010;7832990;8530049",
        "class_list": "",
        "function": "Constitutively active G protein-coupled receptor that maintains high cAMP levels and contributes to several processes including neuronal development, through activation of intracellular signaling pathways via G(s). May be activated by lipid-derived agonists such as oleic acid or sphingosine 1-phosphate, leading to activation of the G(s)/cAMP/PKA signaling pathway (PubMed:12220620, PubMed:39626010)., [UniProtKB, PubMed, PubMed]; Control of gene expression in vascular endothelial cells in the presence of fluid shear stress and determines that it is not a sphingosine 1-phosphate receptor, [RefSeq, PubMed]; GPR6 Structural Insights: Homology Model Construction and Docking Studies. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The GPR6 gene influences the reinforcement learning rate in a computational, neurogenetic model., [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DHS9;J3KQR3;Q17RJ7;Q5SYL0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0038036 sphingosine-1-phosphate receptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "P46095-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P46926-1",
        "uniprot_id": "GNPI1_HUMAN",
        "mass": 32669.0,
        "length": 289,
        "protein_name": "Glucosamine-6-phosphate deaminase 1",
        "gene_name": "GNPDA1",
        "organism": "Human",
        "refseq_name": "glucosamine-6-phosphate deaminase 1",
        "refseq_ac": "NP_005462",
        "gene_names_uniprotkb": "GNPDA1; GNPI; HLN; KIAA0060",
        "gene_names_refseq": "GNP1; GNPDA1; GNPDA; GNPI; GPI; HLN",
        "protein_names_uniprotkb": "Glucosamine-6-phosphate deaminase 1; 3.5.99.6; GlcN6P deaminase 1; Glucosamine-6-phosphate isomerase 1; Protein oscillin",
        "protein_names_refseq": "GNPDA 1; glcN6P deaminase 1; glucosamine-6-phosphate deaminase 1; glucosamine-6-phosphate isomerase 1; oscillin; protein oscillin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10007);  (R-HSA-70171)",
        "pathway_count": 2,
        "publication_count": 102,
        "publication_id_list": "10714828;11237011;11371164;11506403;11780755;12616532;1278465;12965206;13538944;15710582;16511037;17804405;183598;18452278;1871135;18910716;18910717;18927083;19608861;20068231;21807125;22219026;23168256;23446454;23481700;24397554;2462567;25502872;25648650;26024233;26154972;26375851;26811146;26887390;26992070;27862975;2793178;28228285;2846554;28510447;28514659;28832583;28904123;29242379;29393594;29437277;29493099;29557506;2960695;29632711;30315122;30410026;30517626;3170585;31844290;3208766;32157095;32350084;32357974;32387766;32938616;33298915;3355497;33633747;33717175;33912179;33968037;34019948;34171305;34357683;34509645;3453121;34782236;35051231;35154160;3529090;35580925;36215666;36581221;4413246;4555506;4827367;5009693;5687724;6434534;6444721;6451249;6696436;6771269;7144574;7150652;7391027;7717389;7825568;7989588;8117307;8325892;8447317;8786021;9438414;9493266;9714720",
        "class_list": "glycogene",
        "function": "Allosteric kinetics of the isoform 1 of human glucosamine-6-phosphate deaminase., [RefSeq, PubMed]; Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis (PubMed:21807125, PubMed:26887390). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling (PubMed:26887390). Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; GNPDA1 siRNA induced GFAT2 which was hardly measurable in these cells under standard culture conditions, GNPDA2 siRNA increased GFAT1, and GFAT1 siRNA increased the expression of hyaluronan synthase 2 (HAS2). Silencing of GFAT1 stimulated GNPDA1 and GDPDA2, and inhibited cell migration., [RefSeq, PubMed]; Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]).[supplied by OMIM, Jan 2010]., [RefSeq]; Sequence analysis and crystallographic structure of GNP1., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 262,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z3X4;D3DQE7",
        "ec_number_list": "3.5.99.6",
        "go_molecular_function": "GO:0004342 glucosamine-6-phosphate deaminase activity;GO:0042802 identical protein binding;GO:0016853 isomerase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006043 glucosamine catabolic process;GO:0006046 N-acetylglucosamine catabolic process;GO:0006091 generation of precursor metabolites and energy;GO:0005975 carbohydrate metabolic process;GO:0007338 single fertilization",
        "synthesized_glycan_count": 0,
        "hit_score": 10.5,
        "record_id": "P46926-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P48167-1",
        "uniprot_id": "GLRB_HUMAN",
        "mass": 56122.0,
        "length": 497,
        "protein_name": "Glycine receptor subunit beta",
        "gene_name": "GLRB",
        "organism": "Human",
        "refseq_name": "glycine receptor subunit beta isoform A precursor",
        "refseq_ac": "NP_000815",
        "gene_names_uniprotkb": "GLRB",
        "gene_names_refseq": "GLRB; HKPX2",
        "protein_names_uniprotkb": "Glycine receptor subunit beta; Glycine receptor 58 kDa subunit",
        "protein_names_refseq": "glycine receptor 58 kDa subunit; glycine receptor subunit beta isoform A precursor; glycine receptor subunit beta; glycine receptor, beta subunit",
        "tax_id": 9606,
        "disease": "hyperekplexia 2 (Disease Ontology:DOID:0060697)",
        "pathway": " (hsa:2743);  (R-HSA-112314)",
        "pathway_count": 2,
        "publication_count": 65,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11485506;11496371;11882681;11929858;12532186;12684523;1387926;14551753;15028279;15302677;16116092;16144831;16389408;17392525;17652911;18761359;20844345;21180598;21391991;2155780;22715885;22973015;22993341;23238346;24366607;25323946;25333367;25445488;25949526;26238288;26613940;26992070;28291778;29763014;29774051;30779550;31444036;31844290;32157095;32161166;32387766;32488085;32938616;33392160;34087483;34171305;34473954;35051231;35526563;35580925;36010968;36241641;36477533;37821459;38215349;39146932;7507039;7565620;7691500;8717357;9676428;9677400;9950429",
        "class_list": "",
        "function": "Clinical, genetic, and functional characterization of the glycine receptor beta-subunit A455P variant in a family affected by hyperekplexia syndrome., [RefSeq, PubMed]; Gating mechanism of the human alpha1beta GlyR by glycine., [RefSeq, PubMed]; Glycine Receptor beta-Targeting Autoantibodies Contribute to the Pathology of Autoimmune Diseases., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Single nucleotide polymorphism of glrb interacts in a complex manner with Panic Disorder /AgoraphobiaG on a functional systems level and might be involved in the development of PD/AG but not in their treatment., [RefSeq, PubMed]; Subunit of heteromeric glycine-gated chloride channels (PubMed:11929858, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:23238346, PubMed:25445488, PubMed:34473954, PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K3K2;D3DP23;F5GWE1",
        "ec_number_list": "1.8.-.-;1.8.5.1;1.11.1.-;5.6.1.6",
        "go_molecular_function": "GO:0016933 extracellularly glycine-gated ion channel activity;GO:0016934 extracellularly glycine-gated chloride channel activity;GO:0004888 transmembrane signaling receptor activity;GO:0044877 protein-containing complex binding;GO:0016594 glycine binding",
        "go_cellular_component": "GO:0016935 glycine-gated chloride channel complex;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite",
        "go_biological_process": "GO:0001964 startle response;GO:0060012 synaptic transmission, glycinergic;GO:0006811 monoatomic ion transport;GO:0007218 neuropeptide signaling pathway;GO:0007399 nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "P48167-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P49685-1",
        "uniprot_id": "GPR15_HUMAN",
        "mass": 40787.0,
        "length": 360,
        "protein_name": "G protein-coupled receptor 15",
        "gene_name": "GPR15",
        "organism": "Human",
        "refseq_name": "G-protein coupled receptor 15",
        "refseq_ac": "NP_005281",
        "gene_names_uniprotkb": "GPR15",
        "gene_names_refseq": "BOB; GPR15",
        "protein_names_uniprotkb": "G protein-coupled receptor 15; BoB; Brother of Bonzo",
        "protein_names_refseq": "G-protein coupled receptor 15; brother of Bonzo",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2838);  (R-HSA-418555)",
        "pathway_count": 2,
        "publication_count": 84,
        "publication_id_list": "11007482;12036966;12058044;12106601;12180353;12860470;13549488;14671004;1517224;15765929;15769620;15951850;16313925;16687412;16923326;17168849;18044684;18577758;19105585;19876791;19929708;20381629;21036126;21189250;2163110;22645359;2417744;24687066;2491850;25502872;2553411;2553705;26417854;28228285;28467828;28615320;2871555;28832583;28904123;29242379;29443750;29602314;29769354;30315122;30410026;30573663;30833991;3127824;31279028;31399091;31530632;31844290;31983287;32226383;32265295;32350084;32357974;32387766;32497535;32540603;32618402;32715661;33049737;33298915;33633747;33758080;34357683;34509645;35154160;35510660;36551327;37457732;38243565;38459169;38918398;6085243;8340388;8514797;8672451;8838812;9263355;9417641;9651336;9791028",
        "class_list": "",
        "function": "(Microbial infection) Acts as an alternative coreceptor with CD4 for HIV-1 infection., [UniProtKB, PubMed]; Blocking GPR15 Counteracts Integrin-dependent T Cell Gut Homing in Vivo., [RefSeq, PubMed]; Elevated Expression and Activation of GPR15 in Immune Cells in Graves' Disease. Publication Status: Online-Only, [RefSeq, PubMed]; Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiology. Review article Publication Status: Online-Only, [RefSeq, PubMed]; G protein-coupled receptor that plays an important role in immune homeostasis (PubMed:33758080, PubMed:38918398). Acts via its natural ligand GPR15LG, a chemokine-like polypeptide strongly expressed in gastrointestinal tissues. GPR15-GPR15LG signaling axis regulates intestinal homeostasis and inflammation through the migration of immune cells (PubMed:33758080, PubMed:38918398). Controls thereby the specific homing of T-cells, particularly FOXP3+ regulatory T-cells (Tregs), to the large intestine lamina propria (By similarity). Also required for skin localization of thymus-derived dendritic epidermal T-cells (By similarity). Plays an important role in mediating cytoprotective function as well as angiogenesis of thrombomodulin (By similarity). Mechanistically, preferentially signals through the Gi/o pathway to inhibit adenylate cyclase activity and activate a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed:35510660)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012]., [RefSeq]; Thrombin receptor activating peptide-6 decreases acute graft-versus-host disease through activating GPR15., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3MIL4;Q6ISN6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0015026 coreceptor activity;GO:0001618 virus receptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0046718 symbiont entry into host cell;GO:0072678 T cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "P49685-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P49863-1",
        "uniprot_id": "GRAK_HUMAN",
        "mass": 28882.0,
        "length": 264,
        "protein_name": "Granzyme K",
        "gene_name": "GZMK",
        "organism": "Human",
        "refseq_name": "granzyme K precursor",
        "refseq_ac": "NP_002095",
        "gene_names_uniprotkb": "GZMK; TRYP2",
        "gene_names_refseq": "GZMK; GrK; TRYP2",
        "protein_names_uniprotkb": "Granzyme K; 3.4.21.-; Fragmentin-3; GrK; Granzyme-3; NK-Tryp-2; NK-tryptase-2",
        "protein_names_refseq": "NK-Tryp-2; NK-tryptase-2; fragmentin-3; granzyme K (granzyme 3; granzyme K (serine protease, granzyme 3; granzyme K precursor; tryptase II); tryptase II",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3003)",
        "pathway_count": 1,
        "publication_count": 34,
        "publication_id_list": "10480954;12384499;1460416;17308307;18452278;19059912;21760880;24711407;26936634;27920218;29242379;29632711;31530632;31848261;32157095;32488085;3262682;33271118;33912179;34357683;35051231;35494241;35580925;35704599;35881628;36347862;38497867;38903528;39614076;39814882;39914456;40914422;7758581;8656064",
        "class_list": "",
        "function": "Granzyme K mediates IL-23-dependent inflammation and keratinocyte proliferation in psoriasis. Publication Status: Online-Only, [RefSeq, PubMed]; High expression of angiotensin-converting enzyme 2 receptor (ACE-2), transmembrane protease serine (TMPRSS), and P-selectin in platelets lead to thrombosis formation in COVID-19 patients., [RefSeq, PubMed]; Serine protease that initiates the GZMK pathway of the complement system, a cascade of proteins directly activated by CD8(+) T-cells that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:3262682, PubMed:39814882, PubMed:39914456). GZMK is specifically secreted by CD8(+) T-cells and mediates both recognition and initiation steps of GZMK complement pathway (PubMed:39914456). First acts as a pattern recognition receptor, which specifically recognizes and binds heparan sulfate glycosaminoglycans on the pathogen surface to drive opsonization (PubMed:39914456). It then initiates the complement pathway cascade by catalyzing cleavage and activation of C2 and C4, the next components of the complement pathway (PubMed:39814882, PubMed:39914456). GZMK-mediated complement activation is an important contributor to tissue inflammation (PubMed:24711407, PubMed:33271118, PubMed:35704599, PubMed:39614076, PubMed:39814882, PubMed:39914456). Also able to cleave and activate F2R/PAR1 and PAR2/F2RL1, possibly promoting interleukin release (PubMed:21760880, PubMed:26936634, PubMed:35881628). May also regulate apoptosis by catalyzing cleavage and activation of BID, thereby promoting cytochrome C release from mitochrondria (PubMed:17308307)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R563",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005539 glycosaminoglycan binding;GO:0038187 pattern recognition receptor activity;GO:0008236 serine-type peptidase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0106139 symbiont cell surface",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0050729 positive regulation of inflammatory response;GO:0090200 positive regulation of release of cytochrome c from mitochondria;GO:0051604 protein maturation;GO:0031638 zymogen activation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "P49863-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P55259-1",
        "uniprot_id": "GP2_HUMAN",
        "mass": 59480.0,
        "length": 537,
        "protein_name": "Pancreatic secretory granule membrane major glycoprotein GP2",
        "gene_name": "GP2",
        "organism": "Human",
        "refseq_name": "pancreatic secretory granule membrane major glycoprotein GP2 isoform 1 preproprotein",
        "refseq_ac": "NP_001007241",
        "gene_names_uniprotkb": "GP2",
        "gene_names_refseq": "GP2; ZAP75",
        "protein_names_uniprotkb": "Pancreatic secretory granule membrane major glycoprotein GP2; Pancreatic zymogen granule membrane protein GP-2; ZAP75",
        "protein_names_refseq": "glycoprotein 2 (zymogen granule membrane); pancreatic secretory granule membrane major glycoprotein GP2 isoform 1 preproprotein; pancreatic secretory granule membrane major glycoprotein GP2; pancreatic zymogen granule membrane associated protein GP2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2813);  (R-HSA-163125);  (R-HSA-9925561)",
        "pathway_count": 3,
        "publication_count": 22,
        "publication_id_list": "10.1101/2023.09.13.557529;10760606;11072085;11237011;19907495;23090970;24190977;2443973;25576301;29741879;30833945;31844290;32581250;32886311;32897882;33981976;34171305;3422494;34326813;35273390;37074911;8666297",
        "class_list": "",
        "function": "Antibodies Against Glycoprotein 2 Are Specific Biomarkers for Pediatric Crohn's Disease., [RefSeq, PubMed]; Common Variants in NUS1 and GP2 Genes Contributed to the Risk of Gestational Diabetes Mellitus. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response., [UniProtKB, PubMed, PubMed]; Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH., [RefSeq, PubMed]; This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 8,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 8,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 8,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 8818,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 0,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NFM9;A6NJA8;Q13338;Q9UIF1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0009986 cell surface",
        "go_biological_process": "GO:0045087 innate immune response;GO:0002412 antigen transcytosis by M cells in mucosal-associated lymphoid tissue;GO:1990266 neutrophil migration",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "P55259-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q08378-1",
        "uniprot_id": "GOGA3_HUMAN",
        "mass": 167355.0,
        "length": 1498,
        "protein_name": "Golgin subfamily A member 3",
        "gene_name": "GOLGA3",
        "organism": "Human",
        "refseq_name": "golgin subfamily A member 3 isoform 2",
        "refseq_ac": "NP_001166028",
        "gene_names_uniprotkb": "GOLGA3",
        "gene_names_refseq": "GCP170; GOLGA3; MEA-2",
        "protein_names_uniprotkb": "Golgin subfamily A member 3; GCP170; Golgi complex-associated protein of 170 kDa; Golgin-160",
        "protein_names_refseq": "Golgi membrane associated protein; Golgi peripheral membrane protein; SY2/SY10 protein; golgi autoantigen, golgin subfamily a, 3; golgi complex-associated protein of 170 kDa; golgin subfamily A member 3 isoform 2; golgin subfamily A member 3; golgin-160; golgin-165; male enhanced antigen-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2802);  (R-HSA-9696270)",
        "pathway_count": 2,
        "publication_count": 86,
        "publication_id_list": "10664463;10791974;11237011;11940653;12130652;12244061;12842009;14522980;14654843;14732713;15738000;15951434;16481321;17081983;17547437;18452278;18996843;19136556;19664994;20068231;20811643;22223895;23186163;24275569;24690281;24715725;25418920;25505266;25645385;25888806;26154972;26728094;26969432;26992070;27846572;27920218;28218747;28832583;28834231;28904123;29242379;29314611;29351928;29393594;29437277;29467256;29493099;29508533;29557506;29632711;29786170;30315122;30379171;30418433;30429286;30833945;31154438;31217245;31530632;31844290;31848261;31871319;32157095;32161166;32350084;32367404;32387766;32502341;32938616;32983136;33298915;33592498;33968037;33981976;34509645;35051231;35154160;35318648;35580925;36010968;36215666;36284347;38253038;38665916;8315394;9295333",
        "class_list": "",
        "function": "An exome-first approach to aid in the diagnosis of primary ciliary dyskinesia., [RefSeq, PubMed]; Golgi auto-antigen; probably involved in maintaining Golgi structure., [UniProtKB]; Golgin-160 disperses from Golgi membranes in cells subjected to cold temperature. Activated ARF1 can prevent cold-induced dispersal of golgin-160., [RefSeq, PubMed]; NH2 terminal domain of Golgin 160 has a role in nuclear transport and Golgi apparatus localization, [RefSeq, PubMed]; Results indicate that GCP16 is the acylated membrane protein, associated with GCP170, and possibly involved in vesicular transport from the Golgi to the cell surface, [RefSeq, PubMed]; The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Feb 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 22,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 38,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5PKX6;O43241;Q6P9C7;Q86XW3;Q8TDA9;Q8WZA3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0045296 cadherin binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0032580 Golgi cisterna membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 9.2,
        "record_id": "Q08378-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14409-1",
        "uniprot_id": "GLPK3_HUMAN",
        "mass": 60598.0,
        "length": 553,
        "protein_name": "Glycerol kinase 3",
        "gene_name": "GK3",
        "organism": "Human",
        "refseq_name": "glycerol kinase 3",
        "refseq_ac": "NP_001382882",
        "gene_names_uniprotkb": "GK3; GK3P; GKP3; GKTB",
        "gene_names_refseq": "GK3P; GK3; GKP3; GKTB",
        "protein_names_uniprotkb": "Glycerol kinase 3; 2.7.1.30; ATP:glycerol 3-phosphotransferase 3; GK 3; Glycerokinase 3; Glycerol kinase 3 pseudogene; Glycerol kinase, testis specific 1",
        "protein_names_refseq": "glycerol kinase 3 pseudogene; glycerol kinase 3; glycerol kinase pseudogene 3",
        "tax_id": 9606,
        "disease": "glycerol kinase deficiency (Disease Ontology:DOID:0060363); familial hypercholesterolemia (Disease Ontology:DOID:13810)",
        "pathway": " (hsa:2713);  (R-HSA-75109)",
        "pathway_count": 2,
        "publication_count": 26,
        "publication_id_list": "11481335;11672446;12618427;12824082;14521909;14970677;15845384;17158099;18238778;18694939;18718904;19336658;20643956;23481700;25838202;29557506;30315122;30410026;30429286;31154438;31844290;31848261;31998317;32502341;33936100;7987308",
        "class_list": "",
        "function": "May be involved in the regulation of glycerol uptake and metabolism., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6NXP9",
        "ec_number_list": "2.7.1.30",
        "go_molecular_function": "GO:0004370 glycerol kinase activity;GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane",
        "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0046167 glycerol-3-phosphate biosynthetic process;GO:0006641 triglyceride metabolic process;GO:0006071 glycerol metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "Q14409-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14833-1",
        "uniprot_id": "GRM4_HUMAN",
        "mass": 101868.0,
        "length": 912,
        "protein_name": "Metabotropic glutamate receptor 4",
        "gene_name": "GRM4",
        "organism": "Human",
        "refseq_name": "metabotropic glutamate receptor 4 isoform 1 precursor",
        "refseq_ac": "NP_000832",
        "gene_names_uniprotkb": "GRM4; GPRC1D; MGLUR4",
        "gene_names_refseq": "GPRC1D; GRM4; MGLUR4; mGlu4",
        "protein_names_uniprotkb": "Metabotropic glutamate receptor 4; mGluR4",
        "protein_names_refseq": "glutamate receptor, metabotropic 4; metabotropic glutamate receptor 4 isoform 1 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2914);  (R-HSA-418594);  (R-HSA-420499);  (R-HSA-9717207)",
        "pathway_count": 4,
        "publication_count": 82,
        "publication_id_list": "10761935;11007482;11208605;11237011;11525421;11917125;12015988;12120503;1325650;1329206;14634208;15194188;15353592;15385606;15576628;15738140;15951850;16634148;16923326;17167479;17506496;18434541;18577758;18767875;19104071;19696921;20022913;20033988;20555319;21148030;21422378;21795555;23121374;23481700;23632330;23674604;24157691;24214976;24235081;24360415;24633359;24715725;2534964;25853419;26377607;27071541;2748346;28218747;28256214;2834384;29393594;29466837;29557506;29614098;29659026;29744740;30013099;30315122;30563861;34135510;34244459;34357683;7476890;7617140;7620613;7623957;7720699;7759551;7908515;7937899;8015379;8288584;8406495;8738157;8887960;9065781;9131252;9144337;9144651;9473604;9844003;9872316",
        "class_list": "",
        "function": "G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity., [UniProtKB, PubMed, PubMed, PubMed]; L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]., [RefSeq]; Regulation and functional consequences of mGlu4 RNA editing., [RefSeq, PubMed]; Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 44,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KVL9;B7Z1T9;B7Z1U6;F5GXM5;Q5SZ84;Q6ZMQ2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0008066 glutamate receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0098793 presynapse;GO:0016020 membrane",
        "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0007268 chemical synaptic transmission;GO:0007269 neurotransmitter secretion;GO:0043523 regulation of neuron apoptotic process;GO:0051966 regulation of synaptic transmission, glutamatergic",
        "synthesized_glycan_count": 0,
        "hit_score": 8.4,
        "record_id": "Q14833-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q16538-1",
        "uniprot_id": "GP162_HUMAN",
        "mass": 63930.0,
        "length": 588,
        "protein_name": "Probable G protein-coupled receptor 162",
        "gene_name": "GPR162",
        "organism": "Human",
        "refseq_name": "probable G-protein coupled receptor 162 isoform 1",
        "refseq_ac": "NP_055264",
        "gene_names_uniprotkb": "GPR162; GRCA",
        "gene_names_refseq": "A-2; GPR162; GRCA",
        "protein_names_uniprotkb": "Probable G protein-coupled receptor 162; Gene-rich cluster gene A protein",
        "protein_names_refseq": "gene rich cluster, A; gene-rich cluster gene A protein; probable G-protein coupled receptor 162 isoform 1; probable G-protein coupled receptor 162",
        "tax_id": 9606,
        "disease": "diabetes mellitus (Disease Ontology:DOID:9351)",
        "pathway": " (hsa:27239)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;19773279;26827797;29557506;31154438;31848261;33592498;34087483;35051231;8723724;9074930",
        "class_list": "",
        "function": "Data show certain SNPs variants in GPR162 gene associated with impairments in glucose homeostasis in obese patients., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Orphan receptor., [UniProtKB]; This gene was identified upon genomic analysis of a gene-dense region at human chromosome 12p13. It appears to be mainly expressed in the brain; however, its function is not known. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q16664;Q59EH5;Q66K56",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q16538-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q49A17-1",
        "uniprot_id": "GLTL6_HUMAN",
        "mass": 69788.0,
        "length": 601,
        "protein_name": "Polypeptide N-acetylgalactosaminyltransferase-like 6",
        "gene_name": "GALNTL6",
        "organism": "Human",
        "refseq_name": "polypeptide N-acetylgalactosaminyltransferase-like 6",
        "refseq_ac": "NP_001030017",
        "gene_names_uniprotkb": "GALNTL6; GALNT17",
        "gene_names_refseq": "GALNACT20; GALNT17; GALNTL6; GalNAc-T6L",
        "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase-like 6; 2.4.1.41; GalNAc-T17; Polypeptide GalNAc transferase 17; Protein-UDP acetylgalactosaminyltransferase 17; Putative polypeptide N-acetylgalactosaminyltransferase 17; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 17; pp-GaNTase 17",
        "protein_names_refseq": "GaNTase 17; GalNAc transferase 17; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 17; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 20; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6; galNAc-T17; polypeptide GalNAc transferase 17; polypeptide GalNAc transferase-like 6; polypeptide N-acetylgalactosaminyltransferase-like 6; pp-GaNTase 17; protein-UDP acetylgalactosaminyltransferase 17; putative polypeptide N-acetylgalactosaminyltransferase 17",
        "tax_id": 9606,
        "disease": "depressive disorder (Disease Ontology:DOID:1596)",
        "pathway": " (hsa:442117);  (R-HSA-913709)",
        "pathway_count": 2,
        "publication_count": 36,
        "publication_id_list": "10.1101/2023.09.13.557529;10330415;10430883;10753916;11042166;11237011;11283017;11304796;11821425;12855678;1329093;15486459;15489334;15560372;15620693;15815621;17113861;18519826;18537974;20977886;22183981;22186971;24643043;28218747;30779550;32350084;33105351;33592498;35580925;7655172;9295285;9394011;9417100;9435216;9915862;9988682",
        "class_list": "glycogene;glycosyltransferase",
        "function": "A novel member of the human ppGalNAc-T family, ppGalNAc-T20, which has high homology with human ppGalNAc-T10 was identified., [RefSeq, PubMed]; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor., [UniProtKB]; Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; The GALNTL6 Gene rs558129 Polymorphism Is Associated With Power Performance., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 745,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2L4S6",
        "ec_number_list": "2.4.1.41;2.4.1.-",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine",
        "synthesized_glycan_count": 7434,
        "hit_score": 3.9,
        "record_id": "Q49A17-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q4AE62-1",
        "uniprot_id": "QTMAN_HUMAN",
        "mass": 52597.0,
        "length": 458,
        "protein_name": "tRNA-queuosine alpha-mannosyltransferase",
        "gene_name": "QTMAN",
        "organism": "Human",
        "refseq_name": "tRNA-queuosine alpha-mannosyltransferase isoform a",
        "refseq_ac": "NP_001006637",
        "gene_names_uniprotkb": "QTMAN; GTDC1",
        "gene_names_refseq": "GTDC1; Hmat-Xa; QTMAN; mat-Xa",
        "protein_names_uniprotkb": "tRNA-queuosine alpha-mannosyltransferase; 2.4.1.110; Glycosyltransferase-like domain-containing protein 1; Mannosyltransferase-like protein Xa; Mat-Xa; QTMAN",
        "protein_names_refseq": "glycosyltransferase like domain containing 1; glycosyltransferase-like 1; glycosyltransferase-like domain-containing protein 1; mannosyltransferase candidate; mannosyltransferase-like protein Xa; tRNA-queuosine alpha-mannosyltransferase isoform a; tRNA-queuosine alpha-mannosyltransferase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79712)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "11237011;15068588;19826048;21821951;23481700;26811146;28228285;28365779;28832583;30100616;30192525;32387766;32502341;33691108;36010968;37992713",
        "class_list": "glycogene;glycosyltransferase",
        "function": "By deriving iPSCs from this patient and differentiating them into neural progenitor cells (NPCs) and neurons we dissected the disease process at the cellular level and observed defects in both NPCs and neuronal cells. We also showed that disruption of GTDC1 expression in wild type human NPCs and neurons showed a similar phenotype as patient's iPSCs, [RefSeq, PubMed]; Genomewide linkage scan by a targeted, high-density association scan for genetic variants enhancing persistently negative tuberculin skin test (PTST) in two independent Ugandan tuberculosis household cohorts. Association found with SNPs in neighboring genes ZEB2 and GTDC1 supported by both samples. Bioinformatic analysis suggests these variants may affect PTST- by regulating the histone deacetylase pathway., [RefSeq, PubMed]; Glycosyltransferase that specifically catalyzes mannosylation of cytoplasmic tRNA(Asp) modified with queuosine at position 34 (queuosine(34)) (PubMed:37992713). Mannosylates the cyclopentene moiety of queuosine(34) in tRNA(Asp) to form mannosyl-queuosine(34) (PubMed:37992713). Mannosylation of queuosine(34) in tRNA(Asp) is required to slow-down elongation at cognate codons, GAC and GAU, thereby regulating protein translation (PubMed:37992713)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Relatively high expression level in the adult lung, spleen, testis, and peripheral blood leukocyte., [RefSeq, PubMed]; The elevated expression of the Hmat-Xa gene (GTDC1) might serve as a candidate marker for colon adenocarcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 613,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A087X2H5;A8K5P2;D3DP81;G1UFN1;G5EA49;H7BYJ5;Q53SM7;Q53TC5;Q6P7E7;Q6PJB6;Q6WKW6;Q9HAE5",
        "ec_number_list": "2.4.1.110",
        "go_molecular_function": "GO:0016438 tRNA-queuosine(34) beta-mannosyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006417 regulation of translation;GO:0006400 tRNA modification;GO:0002099 tRNA wobble guanine modification",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q4AE62-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NTX7-1",
        "uniprot_id": "RN146_HUMAN",
        "mass": 38950.0,
        "length": 359,
        "protein_name": "E3 ubiquitin-protein ligase RNF146",
        "gene_name": "RNF146",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase RNF146 isoform a",
        "refseq_ac": "NP_001229773",
        "gene_names_uniprotkb": "RNF146",
        "gene_names_refseq": "RNF146",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF146; 2.3.2.27; Dactylidin; Iduna; RING finger protein 146; RING-type E3 ubiquitin transferase RNF146",
        "protein_names_refseq": "E3 ubiquitin-protein ligase RNF146 isoform a; E3 ubiquitin-protein ligase RNF146; RING-type E3 ubiquitin transferase RNF146; dactylidin; iduna",
        "tax_id": 9606,
        "disease": "osteochondrodysplasia (Disease Ontology:DOID:2256)",
        "pathway": " (hsa:81847);  (R-HSA-201681);  (R-HSA-4641257);  (R-HSA-5689880);  (R-HSA-8948751)",
        "pathway_count": 5,
        "publication_count": 155,
        "publication_id_list": "10198061;10444327;10982817;11029007;11035045;11230166;11237011;11357136;11448771;11493532;11566882;11923872;12205098;12223464;12297295;12917689;12917691;14636582;14661020;14981260;15053880;15084453;15208637;15454084;15459103;15813938;15916963;16116452;16214042;16280981;16554443;16723543;16884355;16901786;16964248;16971168;17218260;17234765;17290220;17443180;17873522;17980597;17981138;18077588;18172164;18326623;18423204;18467330;18632802;18636086;19000841;19015242;19125156;19135894;19188362;19345329;19363159;19398555;19424180;19473982;19517271;19619488;19690183;19729658;19759537;19838211;19874889;19910467;20004982;20096447;20228808;20368735;20501646;20858899;21239494;21362556;21383061;21445572;21478859;21532586;21571647;21596315;21602803;21659512;21799911;21825151;21849505;21875946;21962518;22000856;22014570;22029577;22085928;22128162;22216260;22267412;22411803;22427670;22440753;22653731;22773843;23144924;23159851;23256519;23395819;23419514;23486064;23791946;23824326;23825189;24056413;24260525;24270891;24367090;24493797;24896179;25197364;25305019;25547115;25578727;26183061;26280536;26811146;26992070;28228285;28657654;28832583;28834231;28904123;29242379;29557506;30315122;31844290;31848261;32157095;32387766;32488085;32983136;33298915;33392160;33592498;33912179;33968037;34171305;34932366;35051231;35580925;35733260;36284347;37029301;37217939;7578059;9135132;9391096;9501980",
        "class_list": "",
        "function": "Dactylidin may function early in the progression of Alzheimer's disease., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation (PubMed:21478859, PubMed:21799911, PubMed:22267412). May regulate many important biological processes, such as cell survival and DNA damage response (PubMed:21825151, PubMed:22267412). Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex (PubMed:21478859, PubMed:21799911). Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2 (PubMed:21799911). Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation (PubMed:21799911). Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48' (PubMed:21799911). May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location (PubMed:21799911). Neuroprotective protein (PubMed:21602803). Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (By similarity). Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner (By similarity). Does not affect PARP1 activation (By similarity). Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (By similarity). Promotes cell survival after gamma-irradiation (PubMed:21825151). Facilitates DNA repair (PubMed:21825151)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Mutations in the coding regions of the RNF146 and ECHDC1 genes do not contribute to the burden of inherited predisposition of breast cancer in Ashkenazi high risk women. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; SUMOylation of RNF146 results in Axin degradation and activation of Wnt/beta-catenin signaling to promote the progression of hepatocellular carcinoma., [RefSeq, PubMed]; Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 10,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E1P572;Q6FIB2;Q7L8H4;Q96K03;Q96T06;Q9NTX6",
        "ec_number_list": "3.4.19.12;2.4.2.-;2.4.2.30;3.4.25.1;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;2.3.2.27",
        "go_molecular_function": "GO:0072572 poly-ADP-D-ribose binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination;GO:0070936 protein K48-linked ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 15.8,
        "record_id": "Q9NTX7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UPG8-1",
        "uniprot_id": "PLAL2_HUMAN",
        "mass": 54584.0,
        "length": 496,
        "protein_name": "Zinc finger protein PLAGL2",
        "gene_name": "PLAGL2",
        "organism": "Human",
        "refseq_name": "zinc finger protein PLAGL2",
        "refseq_ac": "NP_002648",
        "gene_names_uniprotkb": "PLAGL2; KIAA0198",
        "gene_names_refseq": "PLAGL2; ZNF900",
        "protein_names_uniprotkb": "Zinc finger protein PLAGL2; Pleiomorphic adenoma-like protein 2",
        "protein_names_refseq": "C2H2-type zinc finger protein; pleiomorphic adenoma gene-like 2; pleiomorphic adenoma-like protein 2; zinc finger protein PLAGL2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5326)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "15361364;15585652;24715725;26154972;26992070;28228285;28832583;28834231;29242379;29493099;29557506;30315122;31530632;31844290;31937595;32157095;32357974;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33968037;34509645;35580925;36399309;36437415;36807469;36999803;38500386;9722527",
        "class_list": "",
        "function": "Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification. Erratum:[Acta Neuropathol. 2023 Apr;145(4):511-514. doi: 10.1007/s00401-023-02538-4. PMID: 36786841], [RefSeq, PubMed]; Long non-coding RNA LGALS8-AS1 facilitates PLAGL2-mediated malignant phenotypes in gastric cancer., [RefSeq, PubMed]; PLAGL2 increases adriamycin resistance and EMT in breast cancer cells by activating the Wnt pathway., [RefSeq, PubMed]; PLAGL2 may modulate SP-C expression during lung development., [RefSeq, PubMed]; PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis., [RefSeq, PubMed]; POFUT1 and PLAGL2 are characteristic markers of mucinous colorectal cancer associated with MUC2 expression., [RefSeq, PubMed]; Plag1 and Plagl2 are novel leukemia oncogenes that act by expanding hematopoietic progenitors expressing CbF beta-SMMHC., [RefSeq, PubMed]; Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. [provided by RefSeq, Jul 2008]., [RefSeq]; Shows weak transcriptional activatory activity., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K8T5;E1P5M3;Q92584",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q9UPG8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95793-1",
        "uniprot_id": "STAU1_HUMAN",
        "mass": 63182.0,
        "length": 577,
        "protein_name": "Double-stranded RNA-binding protein Staufen homolog 1",
        "gene_name": "STAU1",
        "organism": "Human",
        "refseq_name": "double-stranded RNA-binding protein Staufen homolog 1 isoform c",
        "refseq_ac": "NP_001032405",
        "gene_names_uniprotkb": "STAU1; STAU",
        "gene_names_refseq": "PPP1R150; STAU1; STAU",
        "protein_names_uniprotkb": "Double-stranded RNA-binding protein Staufen homolog 1",
        "protein_names_refseq": "double-stranded RNA-binding protein Staufen homolog 1 isoform c; protein phosphatase 1, regulatory subunit 150; staufen, RNA binding protein, homolog 1",
        "tax_id": 9606,
        "disease": "atherosclerosis (Disease Ontology:DOID:1936)",
        "pathway": " (hsa:6780)",
        "pathway_count": 1,
        "publication_count": 96,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10022909;10325410;11230166;11237011;18498651;19029303;19413330;19608861;20068231;21406692;23186163;23301498;23481700;23584533;23926355;24129315;24366607;24715725;25418920;25505266;25645385;25810538;25813380;25892735;26154972;26375851;26811146;26929215;27846572;28228285;28904123;29493099;29557506;30301857;30315122;30484775;30779550;30833945;31092671;31154438;31217245;31530632;31611695;31844290;31848261;31998317;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34229054;34357683;34509645;34561969;34932366;35051231;35154160;35251023;35318648;35561310;35580925;36010968;36215666;36232890;36241641;36284347;37217939;37938771;38347726;38665916;38913026;39080743;39138413;40914422",
        "class_list": "",
        "function": "(Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site., [UniProtKB, UniProtKB, UniProtKB]; Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration., [RefSeq, PubMed]; RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling cascade. Publication Status: Online-Only, [RefSeq, PubMed]; STAU1-mediated CNBP mRNA degradation by LINC00665 alters stem cell characteristics in ovarian cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. [provided by RefSeq, Apr 2020]., [RefSeq]; Staufen1 Represses the FOXA1-Regulated Transcriptome by Destabilizing FOXA1 mRNA in Colorectal Cancer Cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K9Z4;E1P5Y1;E1P608;Q5JW29;Q6GTM4;Q9H5B4;Q9H5B5;Q9Y3Q2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003725 double-stranded RNA binding;GO:0008157 protein phosphatase 1 binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol",
        "go_biological_process": "GO:0046726 positive regulation by virus of viral protein levels in host cell;GO:1900273 positive regulation of long-term synaptic potentiation;GO:0034599 cellular response to oxidative stress;GO:0007281 germ cell development;GO:0035418 protein localization to synapse",
        "synthesized_glycan_count": 0,
        "hit_score": 10.6,
        "record_id": "O95793-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P62314-1",
        "uniprot_id": "SMD1_HUMAN",
        "mass": 13282.0,
        "length": 119,
        "protein_name": "Small nuclear ribonucleoprotein Sm D1",
        "gene_name": "SNRPD1",
        "organism": "Human",
        "refseq_name": "small nuclear ribonucleoprotein Sm D1 isoform 2",
        "refseq_ac": "NP_001278845",
        "gene_names_uniprotkb": "SNRPD1",
        "gene_names_refseq": "HsT2456; SMD1; SNRPD1; SNRPD; Sm-D1",
        "protein_names_uniprotkb": "Small nuclear ribonucleoprotein Sm D1; Sm-D autoantigen; Sm-D1; snRNP core protein D1",
        "protein_names_refseq": "Sm-D autoantigen; small nuclear ribonucleoprotein D1 polypeptide 16kDa pseudogene; small nuclear ribonucleoprotein Sm D1 isoform 2; small nuclear ribonucleoprotein Sm D1; snRNP core protein D1",
        "tax_id": 9606,
        "disease": "nephritis (Disease Ontology:DOID:10952); proteinuria (Disease Ontology:DOID:576); connective tissue disease (Disease Ontology:DOID:65); systemic lupus erythematosus (Disease Ontology:DOID:9074); nasopharynx carcinoma (Disease Ontology:DOID:9261)",
        "pathway": " (hsa:6632);  (R-HSA-191859);  (R-HSA-72163);  (R-HSA-72165);  (R-HSA-9754678);  (R-HSA-9770562);  (R-HSA-9918481);  (R-HSA-9943411)",
        "pathway_count": 8,
        "publication_count": 242,
        "publication_id_list": "10.1101/2023.09.13.557529;10025403;10199952;10207048;10500148;10531003;10556282;10601333;10669729;10725331;10851237;10882114;11014198;11060040;11101529;11135666;11233976;11237011;11333016;11333026;11418695;11607023;11714716;11747608;11747828;11748230;11991638;12065586;12095920;12176931;12411573;12414731;12441251;12477934;12682017;12776181;14519844;14625303;14713954;14749727;14762106;15037765;15084397;15146077;15565158;15647753;16263726;16314458;16314521;16372014;16809785;17095540;17128255;17332742;17433364;17606899;17709427;17717186;17940139;18042460;18288197;18322460;18593880;18984161;19052544;19054851;19103666;19165350;19217410;19325628;19536130;19838190;20068231;20211137;20423332;20695905;20980672;21113136;21295486;21516107;21536652;2176635;21816274;21868195;21911577;22046413;22110043;22121020;22365833;22569126;22813749;22922743;22959432;22961380;23222130;23236153;23333303;23345524;23481700;23874216;24076191;24149845;24196718;24304693;24366607;24448447;24715725;24737827;24914973;2524422;2528429;25301780;25301781;25555158;25576301;2558966;25645385;25802875;26092250;26154972;26385511;26420826;26768311;26824387;26912367;26969736;26992070;27108190;27377154;27459055;27510544;27661449;27683217;27846572;27920218;28062851;28076346;28096519;28502770;28781166;28834231;28911096;29186539;29274231;29301961;29360106;29361316;29493099;29557506;2963332;29902443;30139799;30254034;30257008;30315277;30429286;30599162;30705154;30728453;30765414;30975767;31409651;31530632;31799625;31844290;32119511;32157095;32179686;32329775;32350084;32357974;32387766;32494006;32502341;3260384;32680882;32816001;32897882;32908316;32938616;32983136;32995776;32995777;33080218;33091337;33141586;33177556;33188728;33214551;33243851;33268501;33298915;33392160;33446560;33479166;33537174;33592498;33691108;33968037;33981976;34019948;34171305;34301950;34315815;34357683;34373319;34509645;34624207;34822310;34932366;35051231;35177536;35215846;35251023;35385551;35561310;35580925;36010968;36215666;36389825;36610391;36797247;37217939;3757028;37938771;38665916;38969036;7527740;8196654;8566756;8608946;8835860;9016565;9242493;9512519;9524131;9539711;9659921;9671485;9701291;9731529;9845364",
        "class_list": "",
        "function": "Effect of E134K pathogenic mutation of SMN protein on SMN-SmD1 interaction, with implication in spinal muscular atrophy: A molecular dynamics study., [RefSeq, PubMed]; Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA (PubMed:23333303)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 5,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5BTZ1;P13641",
        "ec_number_list": "",
        "go_molecular_function": "GO:1990446 U1 snRNP binding;GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0034709 methylosome",
        "go_biological_process": "GO:0036261 7-methylguanosine cap hypermethylation;GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0008380 RNA splicing;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0000387 spliceosomal snRNP assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 24.7,
        "record_id": "P62314-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q99502-1",
        "uniprot_id": "EYA1_HUMAN",
        "mass": 64593.0,
        "length": 592,
        "protein_name": "Protein phosphatase EYA1",
        "gene_name": "EYA1",
        "organism": "Human",
        "refseq_name": "protein phosphatase EYA1 isoform 1",
        "refseq_ac": "NP_000494",
        "gene_names_uniprotkb": "EYA1",
        "gene_names_refseq": "BOP; BOR; BOS1; EYA1; OFC1; OTFCS",
        "protein_names_uniprotkb": "Protein phosphatase EYA1; 3.1.3.16; 3.1.3.48; Eyes absent homolog 1",
        "protein_names_refseq": "eyes absent homolog 1; protein phosphatase EYA1 isoform 1; protein phosphatase EYA1",
        "tax_id": 9606,
        "disease": "branchiootic syndrome (Disease Ontology:DOID:0060232); branchiootic syndrome 1 (Disease Ontology:DOID:0061209); branchiootorenal syndrome 1 (Disease Ontology:DOID:0111423); branchiootorenal syndrome (Disease Ontology:DOID:14702); eye disease (Disease Ontology:DOID:5614); mitochondrial myopathy (Disease Ontology:DOID:699); otofaciocervical syndrome 1 (MONDO:MONDO:0024532)",
        "pathway": " (hsa:2138);  (R-HSA-5693565);  (R-HSA-9830674)",
        "pathway_count": 3,
        "publication_count": 106,
        "publication_id_list": "10464653;10550055;10655545;10724175;10766245;10802669;10866324;10959836;10973490;10991693;11025670;11114888;11237011;11390408;11409867;11558900;11571274;11573085;11893489;11927591;11934988;12364621;12447390;12485996;12500905;12607003;12607005;12697768;12701758;12773400;12792649;12832489;12890688;14560035;15064416;15201865;15279782;16150728;16377563;16427009;16441263;16651405;16691597;17525332;17525340;17553757;17848578;18001824;18001825;18006705;18077395;18443292;18644861;18767875;19001859;19092802;19117993;19176521;19203578;19203579;19234442;19261749;19351884;19664994;19782031;20016603;20023648;20351172;21280147;21282113;21293379;22234877;22373579;22508508;22589545;22908299;22980979;23508780;24667604;24715725;25645385;28514659;29557506;31217245;31844290;32161166;32488085;32938616;33633747;33691108;33968037;34171305;34405274;35051231;35580925;35698919;36010968;38228108;38627775;38973045;8944023;9020840;9168116;9359046;9361030;9488723",
        "class_list": "",
        "function": "A monoallelic variant in EYA1 is associated with Branchio-Otic syndrome in a Malian family., [RefSeq, PubMed]; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Also has phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) (By similarity). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (By similarity). Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 (By similarity)., [UniProtKB, PubMed, UniProtKB]; Identification and Functional Study of Enhancers of EYA1: The Causative Gene of Branchio-Oto-Renal Syndrome., [RefSeq, PubMed]; Novel likely pathogenic variant in the EYA1 gene causing Branchio oto renal syndrome and the exploration of pathogenic mechanisms. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may play a role in the developing kidney, branchial arches, eye, and ear. Mutations of this gene have been associated with branchiootorenal dysplasia syndrome, branchiootic syndrome, and sporadic cases of congenital cataracts and ocular anterior segment anomalies. A similar protein in mice can act as a transcriptional activator. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Dec 2013]., [RefSeq]; [Clinical phenotypic and genetic analysis of syndrome families with EYA1 gene variants]., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 34,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 7,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NHQ0;G5E9R4;Q0P516;Q8WX80",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.21;3.1.3.18;3.1.3.-;3.1.3.5;3.1.3.2;2.7.10.1;3.1.-.-;3.1.3.67;3.1.3.53;2.7.11.1;3.1.3.52;3.1.3.27;3.1.3.86;3.1.3.36;3.6.-.-;2.3.1.48;2.3.1.-;3.1.3.74",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0140793 histone H2AXY142 phosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0032993 protein-DNA complex",
        "go_biological_process": "GO:0007501 mesodermal cell fate specification;GO:0006351 DNA-templated transcription;GO:0016925 protein sumoylation;GO:0030154 cell differentiation;GO:0045893 positive regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 10.7,
        "record_id": "Q99502-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13630-1",
        "uniprot_id": "FCL_HUMAN",
        "mass": 35893.0,
        "length": 321,
        "protein_name": "GDP-L-fucose synthase",
        "gene_name": "GFUS",
        "organism": "Human",
        "refseq_name": "GDP-L-fucose synthase isoform 1",
        "refseq_ac": "NP_001304712",
        "gene_names_uniprotkb": "GFUS; SDR4E1; TSTA3",
        "gene_names_refseq": "FX; GFUS; P35B; SDR4E1; TSTA3",
        "protein_names_uniprotkb": "GDP-L-fucose synthase; 1.1.1.271; GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase; Protein FX; Red cell NADP(H)-binding protein; Short-chain dehydrogenase/reductase family 4E member 1",
        "protein_names_refseq": "3-5 epimerase/4-reductase; GDP-4-keto-6-deoxy-D-mannose epimerase-reductase; GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase; GDP-L-fucose synthase isoform 1; red cell NADP(H)-binding protein; short chain dehydrogenase/reductase family 4E, member 1; testis tissue sperm-binding protein Li 45a; tissue specific transplantation antigen 3; tissue specific transplantation antigen P35B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7264);  (R-HSA-6787639)",
        "pathway_count": 2,
        "publication_count": 62,
        "publication_id_list": "11237011;11326280;12056818;12753898;16086588;20068231;23774504;23922970;24366607;25645385;26154972;26992070;27738779;27920218;28228285;28510447;28514659;28832583;28904123;29242379;29950151;30305453;30315122;30779550;31217245;31530632;31844290;32157095;32161166;32350084;32357974;32387766;32502341;32897882;32938616;32983136;33042286;33298915;33633747;33691108;33717175;33912179;33936100;33968037;34171305;34211107;34509645;34535569;34725712;34979755;35051231;35580925;36010968;36241641;36284347;36583336;38665916;40914422;7803801;8910301;9525924;9603974",
        "class_list": "glycogene",
        "function": "Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction., [UniProtKB, PubMed, UniProtKB, UniProtKB]; FUCA2 and TSTA3 expression in gastric cancer: candidate biomarkers of malignant transformation., [RefSeq, PubMed]; TSTA3 facilitates esophageal squamous cell carcinoma progression through regulating fucosylation of LAMP2 and ERBB2. Publication Status: Online-Only, [RefSeq, PubMed]; Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008]., [RefSeq]; Tissue-specific transplantation antigen P35B may serve as a novel biomarker for prognosis of patients with esophageal squamous cell carcinoma., [RefSeq, PubMed]; [TSTA3 gene promotes esophageal cancer invasion through MAPK-ERK pathway and downstream MMP2/9]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 423,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R8Y7;D3DWK5;Q567Q9;Q9UDG7",
        "ec_number_list": "1.1.1.271",
        "go_molecular_function": "GO:0042356 GDP-4-dehydro-D-rhamnose reductase activity;GO:0050577 GDP-L-fucose synthase activity;GO:0047918 GDP-mannose 3,5-epimerase activity;GO:0009055 electron transfer activity;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0019673 GDP-mannose metabolic process;GO:0042351 'de novo' GDP-L-fucose biosynthetic process;GO:0010595 positive regulation of endothelial cell migration;GO:0007159 leukocyte cell-cell adhesion;GO:1904906 positive regulation of endothelial cell-matrix adhesion via fibronectin",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "Q13630-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NPI8-1",
        "uniprot_id": "FANCF_HUMAN",
        "mass": 42254.0,
        "length": 374,
        "protein_name": "Fanconi anemia group F protein",
        "gene_name": "FANCF",
        "organism": "Human",
        "refseq_name": "Fanconi anemia group F protein",
        "refseq_ac": "NP_073562",
        "gene_names_uniprotkb": "FANCF",
        "gene_names_refseq": "FAF; FANCF",
        "protein_names_uniprotkb": "Fanconi anemia group F protein; Protein FACF",
        "protein_names_refseq": "Fanconi anemia complementation group F; Fanconi anemia group F protein",
        "tax_id": 9606,
        "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); Fanconi anemia complementation group F (Disease Ontology:DOID:0111088); granulosa cell tumor (Disease Ontology:DOID:2999); adenocarcinoma in situ (Disease Ontology:DOID:4943); primary ovarian insufficiency (Disease Ontology:DOID:5426)",
        "pathway": " (hsa:2188);  (R-HSA-6783310);  (R-HSA-9833482)",
        "pathway_count": 3,
        "publication_count": 213,
        "publication_id_list": "10082513;10348343;10400669;10615118;10620360;10626894;10648614;10848580;10866685;11063725;11096080;11134010;11152499;11156368;11238103;11238927;11239454;11278865;11313968;11337501;11350938;11438540;11500375;11781817;11909525;11939789;11985496;12231563;12397061;12724401;12882984;1373135;14585331;15229216;15299030;15502827;15572677;15737233;15752359;15907845;16116422;16179258;16179259;16373505;16431927;16600570;16717090;16916645;16943440;1695551;16982605;17079286;17082180;17196820;17289582;17412408;17460694;17938197;18082604;18096616;18174376;18550849;18835251;18931676;18957415;19111657;19229320;19416861;19561358;19589784;19596236;19710021;19733181;19804757;19838063;19995904;20102227;20347428;20347429;20385554;20395957;20519500;20603015;20603016;20603073;20670894;20671156;20685959;21072047;21123651;21294215;21464321;21518807;21636578;21701511;21764741;21937648;21978664;21994559;22214662;22258451;22287633;22396592;2247437;22510687;22692201;22986343;23084476;23229543;23325218;23698467;23723247;23732991;24076221;24347309;24366607;24389026;24623135;24623813;24659800;24714562;24726325;24753571;24905007;25430771;25500724;25576301;25653431;25848059;25880248;26432638;26446704;26488609;26716879;26817845;26992070;27208315;27269119;27423063;27846572;27920218;27974558;28063628;28069888;28167698;28281686;28765891;28832583;28834231;28904123;29170442;29175459;29231267;29242379;29348664;29394925;29395325;29440070;29501855;29632046;30174290;30524438;30770398;31031002;31288759;31844290;31848261;32093270;32357974;32387766;32502341;32716602;32801355;32897882;32915143;32938616;33592498;33808629;33911136;33912179;33968037;34087483;34174402;34509645;34974812;35051231;35580925;35685460;35947956;36284347;36712380;37127961;7491766;7515177;7545299;7565688;7693978;7737357;7903669;8576172;8576179;8661426;8810342;8910500;9034343;9079663;9442054;9521856;9528799;9687506;9737981;9819388;9920933",
        "class_list": "",
        "function": "A mutation in the FANCF gene in Iranian patients with Fanconi anemia. This new mutation correlates with a hematological problem (pancytopenia), short stature, and microcephaly and skin hyperpigmentation. Until now, no evidence of malignancy was detected. Publication Status: Online-Only, [RefSeq, PubMed]; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity)., [UniProtKB]; FANCF hypomethylation is associated with colorectal cancer in Han Chinese., [RefSeq, PubMed]; The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q52LM0",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin",
        "go_biological_process": "GO:0006974 DNA damage response;GO:0036297 interstrand cross-link repair",
        "synthesized_glycan_count": 0,
        "hit_score": 21.4,
        "record_id": "Q9NPI8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NV70-1",
        "uniprot_id": "EXOC1_HUMAN",
        "mass": 101982.0,
        "length": 894,
        "protein_name": "Exocyst complex component 1",
        "gene_name": "EXOC1",
        "organism": "Human",
        "refseq_name": "exocyst complex component 1 isoform 1",
        "refseq_ac": "NP_001020095",
        "gene_names_uniprotkb": "EXOC1; BM-012; SEC3L1; SEC3",
        "gene_names_refseq": "BM-102; EXOC1; SEC3L1; SEC3P; SEC3",
        "protein_names_uniprotkb": "Exocyst complex component 1; Exocyst complex component Sec3",
        "protein_names_refseq": "SEC3-like 1; exocyst complex component 1 isoform 1; exocyst complex component Sec3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55763);  (R-HSA-1445148);  (R-HSA-264876);  (R-HSA-5620916);  (R-HSA-9920588)",
        "pathway_count": 5,
        "publication_count": 180,
        "publication_id_list": "10521251;11406615;11462236;11493706;11707400;11904301;12221131;12665801;14617756;14704853;15158452;1528899;15331542;15728366;15878854;15919790;15971998;16038802;16136078;16155582;16158220;16158222;16181645;16213214;16407158;16431365;16537653;16714477;16782012;16880201;16984975;17007872;17030804;17081983;17369524;17574030;17628206;17646400;17956946;17995453;18212344;18452278;18496526;18669648;18685082;19013499;19017632;19153612;19252894;19297529;19413330;19454479;19651622;19690332;19754307;19889084;20068231;20083215;20308425;20308558;20631154;20701589;20837646;20937701;21091435;21145486;21273506;21308844;21406692;21454505;21454690;21550243;21565611;21566123;21713314;21775626;21907143;22389062;22420621;22433857;22983554;23186163;23351793;23481700;23567335;23945166;24173023;24275569;24296415;24366607;24715725;25091901;25418920;2550440;25576301;25645385;25880248;26154972;26375851;2669954;26992070;27543614;27600516;27832191;27846572;27862975;27920218;28218747;2822027;28228285;28514659;28764923;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30315122;30379171;30429286;30550790;31184304;31217245;31495494;31844290;31867016;32152943;32157095;32265295;32357974;32387766;32432721;32488085;32502341;32723473;32778820;32897882;32938616;32983136;33141586;33298915;33485965;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34357683;34509645;34561969;34932366;35051231;35561310;35580925;36010968;36215666;36241641;36284347;37938771;3896518;7626024;8094051;8664345;8916141;9166668;9207799;9631292;9819391",
        "class_list": "",
        "function": "(Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation., [UniProtKB, PubMed]; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB]; Study provides evidence that Sec3 is involved in TGF-beta induced cell migration and epithelial-mesenchymal transition processes, presumably through the regulation of PI3K/Akt signaling activation in A549 cancer cells, [RefSeq, PubMed]; The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q504V4;Q8WUE7;Q96T15;Q9NZE4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0015031 protein transport;GO:0051607 defense response to virus;GO:0016241 regulation of macroautophagy;GO:0000281 mitotic cytokinesis;GO:0006887 exocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 18.3,
        "record_id": "Q9NV70-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y5P6-1",
        "uniprot_id": "GMPPB_HUMAN",
        "mass": 39834.0,
        "length": 360,
        "protein_name": "Mannose-1-phosphate guanylyltransferase catalytic subunit beta",
        "gene_name": "GMPPB",
        "organism": "Human",
        "refseq_name": "mannose-1-phosphate guanylyltransferase catalytic subunit beta isoform 2",
        "refseq_ac": "NP_068806",
        "gene_names_uniprotkb": "GMPPB",
        "gene_names_refseq": "GMPPB; LGMDR19; MDDGA14; MDDGB14; MDDGC14",
        "protein_names_uniprotkb": "Mannose-1-phosphate guanylyltransferase catalytic subunit beta; 2.7.7.13; GDP-mannose pyrophosphorylase B; GTP-mannose-1-phosphate guanylyltransferase beta",
        "protein_names_refseq": "GTP-mannose-1-phosphate guanylyltransferase beta; mannose-1-phosphate guanyltransferase beta; mannose-1-phosphate guanylyltransferase catalytic subunit beta isoform 2; mannose-1-phosphate guanylyltransferase catalytic subunit beta",
        "tax_id": 9606,
        "disease": "autosomal recessive limb-girdle muscular dystrophy type 2T (Disease Ontology:DOID:0110294); congenital muscular dystrophy-dystroglycanopathy type A14 (Disease Ontology:DOID:0111233); muscular dystrophy-dystroglycanopathy (Disease Ontology:DOID:0112374); muscular dystrophy-dystroglycanopathy type B14 (Disease Ontology:DOID:0112377)",
        "pathway": " (hsa:29925);  (R-HSA-446205)",
        "pathway_count": 2,
        "publication_count": 47,
        "publication_id_list": "10980531;11082198;11237011;16540464;19901254;20068231;20307617;20877624;23481700;23719902;23768512;24035193;25892735;26133662;26310427;28063628;28433477;28478914;28510447;28832583;29242379;29393594;29632046;29769354;29786170;31844290;32387766;32938616;33141586;33298915;33592498;33968037;33986552;34333724;34509645;34633329;35051231;35154160;35580925;36010968;36241641;37834154;5946626;8307007;9070917;9119384;9140401",
        "class_list": "glycogene",
        "function": "A founder mutation in the GMPPB gene [c.1000G > A (p.Asp334Asn)] causes a mild form of limb-girdle muscular dystrophy/congenital myasthenic syndrome (LGMD/CMS) in South Indian patients., [RefSeq, PubMed]; Catalytic subunit of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex (PubMed:33986552). Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids (PubMed:33986552). Can catalyze the reverse reaction in vitro (PubMed:33986552). Together with GMPPA regulates GDP-alpha-D-mannose levels (PubMed:33986552)., [UniProtKB, PubMed]; Catalytic subunit of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex. Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. Can catalyze the reverse reaction in vitro. Together with GMPPA regulates GDP-alpha-D-mannose levels., [UniProtKB, UniProtKB, UniProtKB]; Distinct and Recognisable Muscle MRI Pattern in a Series of Adults Harbouring an Identical GMPPB Gene Mutation., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Silencing GMPPB Inhibits the Proliferation and Invasion of GBM via Hippo/MMP3 Pathways. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is thought to encode a GDP-mannose pyrophosphorylase. The encoded protein catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in the production of N-linked oligosaccharides. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 514,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K6N5;Q9H7U3",
        "ec_number_list": "2.7.7.13",
        "go_molecular_function": "GO:0004475 mannose-1-phosphate guanylyltransferase (GTP) activity;GO:0005525 GTP binding;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0120508 GDP-mannose pyrophosphorylase complex",
        "go_biological_process": "GO:0019673 GDP-mannose metabolic process;GO:0009298 GDP-mannose biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "Q9Y5P6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P28358-1",
        "uniprot_id": "HXD10_HUMAN",
        "mass": 38411.0,
        "length": 340,
        "protein_name": "Homeobox protein Hox-D10",
        "gene_name": "HOXD10",
        "organism": "Human",
        "refseq_name": "homeobox protein Hox-D10",
        "refseq_ac": "NP_002139",
        "gene_names_uniprotkb": "HOXD10; HOX4D; HOX4E",
        "gene_names_refseq": "HOX4D; HOX4E; HOX4; HOXD10; Hox-4.4",
        "protein_names_uniprotkb": "Homeobox protein Hox-D10; Homeobox protein Hox-4D; Homeobox protein Hox-4E",
        "protein_names_refseq": "homeo box 4D; homeo box D10; homeobox protein Hox-4D; homeobox protein Hox-4E; homeobox protein Hox-D10",
        "tax_id": 9606,
        "disease": "congenital vertical talus (Disease Ontology:DOID:0111568)",
        "pathway": " (hsa:3236)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "1351871;15146389;1756725;2574852;32350084;34292663;34825321;35580925;35964231;37217939;38829908",
        "class_list": "",
        "function": "Circ_0000317/microRNA-520g/HOXD10 axis affects the biological characteristics of colorectal cancer., [RefSeq, PubMed]; Circ_0077109 sponges miR-139-5p and upregulates HOXD10 in trophoblast cells as potential mechanism for preeclampsia progression., [RefSeq, PubMed]; Joint-specific regulation of homeobox D10 expression in rheumatoid arthritis fibroblast-like synoviocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]; This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as 'rocker-bottom foot' deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]., [RefSeq]; Upregulation of homeobox D10 expression suppresses invasion and migration of clear cell renal cell carcinoma through targeting of E-cadherin., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6NT10",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045786 negative regulation of cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "P28358-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q1MX18-1",
        "uniprot_id": "INSC_HUMAN",
        "mass": 63469.0,
        "length": 579,
        "protein_name": "Protein inscuteable homolog",
        "gene_name": "INSC",
        "organism": "Human",
        "refseq_name": "protein inscuteable homolog isoform a",
        "refseq_ac": "NP_001027024",
        "gene_names_uniprotkb": "INSC",
        "gene_names_refseq": "INSC",
        "protein_names_uniprotkb": "Protein inscuteable homolog",
        "protein_names_refseq": "inscuteable spindle orientation adaptor protein; protein inscuteable homolog isoform a; protein inscuteable homolog",
        "tax_id": 9606,
        "disease": "Charcot-Marie-Tooth disease type 2 (Disease Ontology:DOID:0050539)",
        "pathway": " (hsa:387755)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11237011;12469229;16458856;20065032;22074847;29393594;29523789;34224794;35051231;38589651",
        "class_list": "",
        "function": "A missense mutation in human INSC causes peripheral neuropathy., [RefSeq, PubMed]; Cloning of two distinct cDNAs from Insc gene, which is differentially expressed from alternative first exons;Insc proteins bind to the Pins homologues LGN and AGS3, and also to Par3 and Par3beta, [RefSeq, PubMed]; Genome-wide association study identified INSC gene associated with Trail Making Test Part A and Alzheimer's disease related cognitive phenotypes., [RefSeq, PubMed]; In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]., [RefSeq]; In mammary stem cells, the asymmetric domain of Insc bound to LGN:Galphai(GDP) suffices to drive asymmetric fate, and reverts aberrant symmetric divisions induced by p53 loss. Publication Status: Online-Only, [RefSeq, PubMed]; MInsc-LGN interaction is vital for stabilization of LGN and for intracellular localization of mInsc., [RefSeq, PubMed]; May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex (PubMed:16458856). Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity)., [UniProtKB, UniProtKB, PubMed]; These data present AGS3, G-proteins, and mInsc as candidate proteins involved in regulating cellular stress associated with protein-processing pathologies., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0PJX5;Q1MX19;Q3C1V6;Q4AC95;Q4AC96;Q4AC97;Q4AC98",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0008093 cytoskeletal anchor activity",
        "go_cellular_component": "GO:0045179 apical cortex;GO:0005886 plasma membrane;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0009786 regulation of asymmetric cell division;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0031647 regulation of protein stability;GO:0008356 asymmetric cell division",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q1MX18-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P50479-1",
        "uniprot_id": "PDLI4_HUMAN",
        "mass": 35398.0,
        "length": 330,
        "protein_name": "PDZ and LIM domain protein 4",
        "gene_name": "PDLIM4",
        "organism": "Human",
        "refseq_name": "PDZ and LIM domain protein 4 isoform 2",
        "refseq_ac": "NP_001124499",
        "gene_names_uniprotkb": "PDLIM4; RIL",
        "gene_names_refseq": "PDLIM4; RIL",
        "protein_names_uniprotkb": "PDZ and LIM domain protein 4; LIM protein RIL; Reversion-induced LIM protein",
        "protein_names_refseq": "LIM domain protein; LIM protein RIL; PDZ and LIM domain protein 4 isoform 2; PDZ and LIM domain protein 4; enigma homolog; reversion-induced LIM protein",
        "tax_id": 9606,
        "disease": "osteoporosis (Disease Ontology:DOID:11476)",
        "pathway": " (hsa:8572)",
        "pathway_count": 1,
        "publication_count": 40,
        "publication_id_list": "10826496;11237011;12908099;14729062;19307596;19651622;19664995;20120020;20166139;20230923;21406692;21636573;21644927;23186163;23301498;23481700;24275569;25158098;28832583;28834231;29242379;29393594;29557506;30578378;31376371;31844290;32157095;32488085;32983136;33592498;33968037;34932366;35051231;35251023;35318648;35580925;36010968;36284347;38665916;9573374",
        "class_list": "",
        "function": "Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration., [UniProtKB, PubMed]; Low expression of PDLIM4 is associated with growth and invasion of ovarian cancer., [RefSeq, PubMed]; Our study provides supportive evidence for the contribution of PDLIM4 gene polymorphisms to the susceptibility to osteoporotic fracture and suggests that rs270611 and rs3900945 are genetic risk factors, while rs366512 might be a genetic protective factor against osteoporotic fracture in elderly Han individuals. Publication Status: Online-Only, [RefSeq, PubMed]; RIL and its variant sequences may be an important determinant of osteoporosis GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Ril modulates actin stress fiber turnover and enhances the association with actinin and actins., [RefSeq, PubMed]; Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle (PubMed:19307596). Involved in reorganization of the actin cytoskeleton (PubMed:21636573). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R8U1;Q53Y39;Q96AT8;Q9BTW8;Q9Y292",
        "ec_number_list": "",
        "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051393 alpha-actinin binding",
        "go_cellular_component": "GO:0034777 recycling endosome lumen;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0098976 excitatory chemical synaptic transmission;GO:0007507 heart development;GO:0030036 actin cytoskeleton organization;GO:0061061 muscle structure development",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "P50479-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q12884-1",
        "uniprot_id": "SEPR_HUMAN",
        "mass": 87713.0,
        "length": 760,
        "protein_name": "Prolyl endopeptidase FAP",
        "gene_name": "FAP",
        "organism": "Human",
        "refseq_name": "prolyl endopeptidase FAP isoform 2",
        "refseq_ac": "NP_001278736",
        "gene_names_uniprotkb": "FAP",
        "gene_names_refseq": "DPPIV; FAPA; FAPalpha; FAP; SIMP",
        "protein_names_uniprotkb": "Prolyl endopeptidase FAP; 170 kDa melanoma membrane-bound gelatinase; 3.4.14.5; 3.4.21.-; 3.4.21.26; Dipeptidyl peptidase FAP; FAPalpha; Fibroblast activation protein alpha; Gelatine degradation protease FAP; Integral membrane serine protease; Post-proline cleaving enzyme; SIMP; Seprase; Serine integral membrane protease; Surface-expressed protease",
        "protein_names_refseq": "170 kDa melanoma membrane-bound gelatinase; dipeptidyl peptidase FAP; gelatine degradation protease FAP; integral membrane serine protease; post-proline cleaving enzyme; prolyl endopeptidase FAP isoform 2; prolyl endopeptidase FAP; seprase; surface-expressed protease",
        "tax_id": 9606,
        "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908)",
        "pathway": " (hsa:2191)",
        "pathway_count": 1,
        "publication_count": 54,
        "publication_id_list": "10.1101/2023.09.13.557529;10347120;10455171;10593948;10644713;11237011;12376466;14751930;15809306;16175601;16223769;16335952;16410248;16480718;16651416;17105646;17381073;18095711;18262497;20707604;21288888;21314817;2172980;23090970;24190977;24371721;24717288;25576301;25892735;27846572;29391424;29557506;29741879;31844290;32157095;32350084;32938616;33592498;35051231;35580925;36284347;37074911;37856562;37938771;38100414;38278714;38665916;38685696;38955058;7519584;7911242;7923219;9065413;9247085",
        "class_list": "",
        "function": "Altered Plasma Levels and Tissue Expression of Fibroblast Activation Protein Alpha in Giant Cell Arteritis., [RefSeq, PubMed]; Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16410248, PubMed:16480718, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vitronectin, tenascin, laminin, fibronectin, fibrin or casein (PubMed:10347120, PubMed:10455171, PubMed:12376466, PubMed:16223769, PubMed:16651416, PubMed:18095711, PubMed:2172980, PubMed:7923219, PubMed:9065413). Also has dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro (PubMed:10347120, PubMed:10593948, PubMed:16175601, PubMed:16223769, PubMed:16410248, PubMed:16651416, PubMed:17381073, PubMed:21314817, PubMed:24371721, PubMed:24717288). Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB) (PubMed:21314817). The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Expression of FAP in Oral Leukoplakia and Oral Squamous Cell Carcinoma., [RefSeq, PubMed]; Expression of fibroblast activation protein-alpha in human deep vein thrombosis., [RefSeq, PubMed]; FAP expression in adipose tissue macrophages promotes obesity and metabolic inflammation., [RefSeq, PubMed]; FSHD muscle shows perturbation in fibroadipogenic progenitor cells, mitochondrial function and alternative splicing independently of inflammation., [RefSeq, PubMed]; The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 19,
        "reported_glycation": 0,
        "reported_snv": 40,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 27,
        "disease_count": 4,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O00199;Q53TP5;Q86Z29;Q99998;Q9UID4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0002020 protease binding;GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0005178 integrin binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface",
        "go_biological_process": "GO:0060244 negative regulation of cell proliferation involved in contact inhibition;GO:0097325 melanocyte proliferation;GO:1902362 melanocyte apoptotic process;GO:1903054 negative regulation of extracellular matrix organization;GO:0001525 angiogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 8.9,
        "record_id": "Q12884-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9C019-1",
        "uniprot_id": "TRI15_HUMAN",
        "mass": 52113.0,
        "length": 465,
        "protein_name": "E3 ubiquitin-protein ligase TRIM15",
        "gene_name": "TRIM15",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase TRIM15",
        "refseq_ac": "NP_150232",
        "gene_names_uniprotkb": "TRIM15; RNF93; ZNF178; ZNFB7",
        "gene_names_refseq": "RNF93; TRIM15; ZNF178; ZNFB7",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM15; 2.3.2.27; RING finger protein 93; Zinc finger protein 178; Zinc finger protein B7",
        "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM15; RING finger protein 93; tripartite motif-containing protein 15; zinc finger protein 178; zinc finger protein B7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:89870)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "11237011;11331580;23077300;25015296;30379171;33515345;33537174;34142270;34497368;34871740;35494241;35534896;36010968;36241641;36670097;8304341",
        "class_list": "",
        "function": "E3 ligase TRIM15 facilitates non-small cell lung cancer progression through mediating Keap1-Nrf2 signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis (PubMed:23077300, PubMed:34142270). Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). Also plays a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN (PubMed:25015296). Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS (PubMed:23077300). Inhibits NF-kappa-B activation by turnover of 'Lys-63'-linked ubiquitination of MAP3K7/TAK1. Mechanistically, prevents TRIM8 cytoplasmic translocation and thus inhibits TRIM8-mediated 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 in the cytoplasm (PubMed:34871740). Also plays an important regulatory effect on the activation of hepatic stellate cells (HSCs)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Knockdown of TRIM15 inhibits the proliferation, migration and invasion of esophageal squamous cell carcinoma cells through inactivation of the Wnt/beta-catenin signaling pathway., [RefSeq, PubMed]; TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination., [RefSeq, PubMed]; TRIM15 forms a regulatory loop with the AKT/FOXO1 axis and LASP1 to modulate the sensitivity of HCC cells to TKIs. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2BEC9;O95604;Q8IUX9;Q9C018",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0140313 molecular sequestering activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005925 focal adhesion",
        "go_biological_process": "GO:0044790 suppression of viral release by host;GO:0045087 innate immune response;GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction;GO:1900246 positive regulation of RIG-I signaling pathway;GO:0032481 positive regulation of type I interferon production",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q9C019-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q16772-1",
        "uniprot_id": "GSTA3_HUMAN",
        "mass": 25302.0,
        "length": 222,
        "protein_name": "Glutathione S-transferase A3",
        "gene_name": "GSTA3",
        "organism": "Human",
        "refseq_name": "glutathione S-transferase A3 isoform 1",
        "refseq_ac": "NP_000838",
        "gene_names_uniprotkb": "GSTA3",
        "gene_names_refseq": "GSTA3-3; GSTA3; GTA3",
        "protein_names_uniprotkb": "Glutathione S-transferase A3; 2.5.1.18; GST class-alpha member 3; Glutathione S-transferase A3-3",
        "protein_names_refseq": "GST class-alpha member 3; S-(hydroxyalkyl)glutathione lyase A3; glutathione S-alkyltransferase A3; glutathione S-aralkyltransferase A3; glutathione S-aryltransferase A3; glutathione S-transferase A3 isoform 1; glutathione S-transferase A3-3",
        "tax_id": 9606,
        "disease": "obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:2940);  (R-HSA-156590);  (R-HSA-9818027)",
        "pathway_count": 3,
        "publication_count": 82,
        "publication_id_list": "10329152;10587441;10706635;10733945;10783391;10821856;11237011;11309284;11327815;11418619;11904223;12042665;12211029;12234984;12235164;12506115;12627223;14742434;15448164;15520857;15590625;15595823;15728556;16081649;16298388;16314513;16548513;17234762;17942419;19028565;19273602;19562805;19608619;20083122;20085333;20460467;21106529;21668448;21775727;22522127;22667998;22995213;23027624;23162467;24041992;24739064;25002527;25248748;27100828;27653015;27756681;28005267;28904123;28985506;29393594;29693710;29959055;30106150;31597407;32284348;32601262;33043019;33089654;33462411;33592498;3372534;33774477;3770744;4768551;7959763;8182750;8203914;8307579;8331657;8431482;8703034;8812420;9240432;9278457;9480897;9551553;9839448",
        "class_list": "",
        "function": "Analysis of how isomerization of the steroid Delta(5)-androstene-3,17-dione by the glutathione transferase A3-3, [RefSeq, PubMed]; Certain core genes, including COL12A1, glutathione Stransferase alpha3 (GSTA3), fibrinogen alpha chain (FGA) and fibrinogen gamma chain (FGG), were the first reported to be associated with Gastric Cancer. Survival analysis suggested that these four genes, COL12A1 (P=0.002), GSTA3 (P=3.4x106), FGA (P=0.00075) and FGG (P=1.4x105), were significant poor prognostic factors of gastric cancer., [RefSeq, PubMed]; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively. Has substantial activity toward aflatoxin B1-8,9-epoxide (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]; Density functional theory calculations used to propose a refined mechanism for the isomerization of delta(5)-androstene-3,17-dione catalyzed by GST A3-3, [RefSeq, PubMed]; GSTA3 expression is significantly downregulated in human masticatory mucosa during wound healing, [RefSeq, PubMed]; Inhibitory effect of glutathione S-transferase A3 in the progression of cutaneous squamous cell carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43468;Q068V6;Q8WWA8;Q9H415",
        "ec_number_list": "2.5.1.18;5.2.1.2;5.3.99.2;1.11.1.-;5.3.3.-;1.1.1.270;1.1.1.145;5.3.3.1;1.1.1.210;1.20.4.2;1.8.5.1;4.4.1.20",
        "go_molecular_function": "GO:0004364 glutathione transferase activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006805 xenobiotic metabolic process;GO:0006749 glutathione metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 8.3,
        "record_id": "Q16772-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P10144-1",
        "uniprot_id": "GRAB_HUMAN",
        "mass": 27716.0,
        "length": 247,
        "protein_name": "Granzyme B",
        "gene_name": "GZMB",
        "organism": "Human",
        "refseq_name": "granzyme B isoform 1 preproprotein",
        "refseq_ac": "NP_004122",
        "gene_names_uniprotkb": "GZMB; CGL1; CSPB; CTLA1; GRB",
        "gene_names_refseq": "C11; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTLA1; CTSGL1; GZMB; HLP; SECT",
        "protein_names_uniprotkb": "Granzyme B; 3.4.21.79; C11; CTLA-1; CTSGL1; Cathepsin G-like 1; Cytotoxic T-lymphocyte proteinase 2; Fragmentin-2; Granzyme-2; HLP; Human lymphocyte protein; Lymphocyte protease; SECT; T-cell serine protease 1-3E",
        "protein_names_refseq": "T-cell serine protease 1-3E; cathepsin G-like 1; cytotoxic T-lymphocyte proteinase 2; cytotoxic serine protease B; fragmentin 2; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme B isoform 1 preproprotein; human lymphocyte protein",
        "tax_id": 9606,
        "disease": "COVID-19 (Disease Ontology:DOID:0080600); bronchiolitis obliterans (Disease Ontology:DOID:2799); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); brain infarction (Disease Ontology:DOID:3454)",
        "pathway": " (hsa:3002);  (R-HSA-2197563);  (R-HSA-5620971);  (R-HSA-75108);  (R-HSA-9725371)",
        "pathway_count": 5,
        "publication_count": 90,
        "publication_id_list": "11099414;11101851;11114298;11169414;11209755;11237011;11325591;11751994;11866432;11986231;12721789;12748172;12804595;15340161;16009132;16897187;17110082;17111047;17284587;17416736;17690253;17922009;18024471;18097461;18724371;1985927;19859801;20015877;20038786;20493732;21715655;22299025;22955283;2323780;2332171;2365998;24060861;24088571;25313744;25818168;26375003;26508369;27281216;27383986;27418190;27553022;2788607;28045099;28392147;28459430;28832583;29177860;29242379;29351928;29493099;2953813;29539421;29588546;29891674;29898893;29990470;30143555;30692217;30976076;31113851;31366041;31390744;31434245;31844290;31953257;32109412;32188940;32367036;3258865;3261871;3262682;3263427;32820063;32983136;33691108;35051231;35580925;38000677;38072840;38374566;38733267;40914422;8258716;9852092;9930702",
        "class_list": "",
        "function": "Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:1985927, PubMed:3262682, PubMed:3263427). It cleaves after Asp (PubMed:1985927, PubMed:8258716). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death (PubMed:31953257, PubMed:32188940). Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis (PubMed:9852092). Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Does the expression of granzyme B participate in inflammation, fibrosis, and fertility of hydatid cysts? Publication Status: Online-Only, [RefSeq, PubMed]; Granzyme B is elevated in esophageal biopsies from children with eosinophilic esophagitis., [RefSeq, PubMed]; Identifying the association between polymorphisms in the GZMB and IFIH1 genes and psoriasis in Egyptians., [RefSeq, PubMed]; Molecular and clinicopathological features of granzyme B-negative extranodal NK/T-cell lymphoma. Review article, [RefSeq, PubMed]; This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 4,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N1D2;Q9UCC1",
        "ec_number_list": "3.4.21.79;2.3.1.48;2.3.1.-",
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0006915 apoptotic process;GO:0017148 negative regulation of translation;GO:0031640 killing of cells of another organism;GO:0070269 pyroptotic inflammatory response;GO:0051604 protein maturation",
        "synthesized_glycan_count": 0,
        "hit_score": 9.6,
        "record_id": "P10144-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q03167-1",
        "uniprot_id": "TGBR3_HUMAN",
        "mass": 93499.0,
        "length": 851,
        "protein_name": "Transforming growth factor beta receptor type 3",
        "gene_name": "TGFBR3",
        "organism": "Human",
        "refseq_name": "transforming growth factor beta receptor type 3 isoform b precursor",
        "refseq_ac": "NP_001182612",
        "gene_names_uniprotkb": "TGFBR3",
        "gene_names_refseq": "BGCAN; TGFBR3; betaglycan",
        "protein_names_uniprotkb": "Transforming growth factor beta receptor type 3; Betaglycan; TGF-beta receptor type 3; TGF-beta receptor type III; TGFR-3; Transforming growth factor beta receptor III",
        "protein_names_refseq": "TGF-beta receptor type 3; TGF-beta receptor type III; TGFR-3; betaglycan proteoglycan; transforming growth factor beta receptor III; transforming growth factor beta receptor type 3 isoform b precursor",
        "tax_id": 9606,
        "disease": "endometrial adenocarcinoma (Disease Ontology:DOID:2870)",
        "pathway": " (hsa:7049);  (R-HSA-1502540);  (R-HSA-190370);  (R-HSA-190373);  (R-HSA-201451);  (R-HSA-2173789);  (R-HSA-9839383);  (R-HSA-9839389);  (R-HSA-9839394);  (R-HSA-9839397);  (R-HSA-9839406)",
        "pathway_count": 11,
        "publication_count": 127,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10458166;10587654;10712517;10746731;10944857;11016919;11100470;11117535;11121043;11141505;11158580;11237011;11278251;11294897;11323414;11390472;11509558;11571290;11714695;11779505;12151385;12482908;12519765;12592392;12627230;12821673;12857866;12958365;1333192;1333888;1379698;15087470;15123686;15324302;15350224;15564041;15863029;16140969;16507368;1656221;16597617;16672363;16764984;16982625;17029022;17068149;17272393;17311849;17356069;17906079;18166170;18184661;18299279;18469808;18512783;18951876;19325136;19416857;19696444;19720988;19726563;20117945;20153821;20625381;21871877;22299025;22562249;23290524;23584533;24190977;28467828;29242379;29557506;29632711;30429286;30459171;30467960;31154438;31409900;31611695;31844290;31848261;32157095;32350084;33626330;33968037;33981976;34357683;34433824;34910520;35051231;35251023;35318648;35580925;36241641;36976645;37074911;37222488;38730107;39092729;7644468;7693660;7737999;7791754;8047140;8119126;8196624;8242743;8622651;8622701;8653785;8721982;8893010;8947046;8980228;9032295;9136927;9139660;9233797;9311995;9346966;9436979;9459292;9730987;9865696",
        "class_list": "glycogene",
        "function": "(Microbial infection) May act as a receptor for human cytomegalovirus in different cell types by interacting with HCMV trimer composed of GO, GH and GL., [UniProtKB, PubMed]; A review on the role of TbetaRIII as a suppressor of cancer progression and/or as a metastasis suppressor. Review article, [RefSeq, PubMed]; Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis (PubMed:12958365, PubMed:19416857). Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5 (PubMed:18184661). Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking (PubMed:19726563). Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin (PubMed:22562249). By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B (PubMed:19416857, PubMed:19325136). In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility (By similarity). Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization (PubMed:19416857). Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MEX3B inhibits collagen production in eosinophilic nasal polyps by downregulating epithelial cell TGFBR3 mRNA stability. Publication Status: Online-Only, [RefSeq, PubMed]; Polymorphism of Transforming Growth Factor TGFB and Its Receptors TGFBRI, TGFBRII, TGFBRIIII Genes in Western Siberia Patients with Open-Angle Glaucoma., [RefSeq, PubMed]; TGF-beta1-mediates downregulation of TbetaRIII mRNA expression through effects on the ALK5/Smad2/3 pathway., [RefSeq, PubMed]; The Role of TGFBR3 in the Development of Lung Cancer. Review article, [RefSeq, PubMed]; This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]., [RefSeq]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 962,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 1,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AUW8;A8K5N0;B9EG88;Q5T2T4;Q5U731;Q9UGI2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0008201 heparin binding;GO:0015026 coreceptor activity;GO:0005160 transforming growth factor beta receptor binding;GO:0005024 transforming growth factor beta receptor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface",
        "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0060318 definitive erythrocyte differentiation;GO:0001889 liver development;GO:0006955 immune response;GO:0010628 positive regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 13.8,
        "record_id": "Q03167-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P29992-1",
        "uniprot_id": "GNA11_HUMAN",
        "mass": 42123.0,
        "length": 359,
        "protein_name": "Guanine nucleotide-binding protein subunit alpha-11",
        "gene_name": "GNA11",
        "organism": "Human",
        "refseq_name": "guanine nucleotide-binding protein subunit alpha-11",
        "refseq_ac": "NP_002058",
        "gene_names_uniprotkb": "GNA11; GA11",
        "gene_names_refseq": "FBH2; FBH; FHH2; GNA-11; GNA11; HG1K; HHC2; HYPOC2",
        "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit alpha-11; 3.6.5.-; G alpha-11; G protein subunit alpha-11; Guanine nucleotide-binding protein G(y) subunit alpha",
        "protein_names_refseq": "g alpha-11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class); guanine nucleotide-binding protein G(y) subunit alpha; guanine nucleotide-binding protein subunit alpha-11; heterotrimeric guanine nucleotide-binding protein 1K",
        "tax_id": 9606,
        "disease": "familial hypocalciuric hypercalcemia 2 (Disease Ontology:DOID:0060701); autosomal dominant hypocalcemia 2 (Disease Ontology:DOID:0090108); McCune Albright syndrome (Disease Ontology:DOID:1858); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:2767);  (R-HSA-112043);  (R-HSA-202040);  (R-HSA-399997);  (R-HSA-416476);  (R-HSA-418592);  (R-HSA-428930);  (R-HSA-434316);  (R-HSA-456926);  (R-HSA-6814122);  (R-HSA-9856530);  (R-HSA-9860927)",
        "pathway_count": 12,
        "publication_count": 185,
        "publication_id_list": "10191087;10215864;10376603;10567430;10639123;10649434;10727532;10759852;10764742;10861009;11015615;11118617;11237011;11588141;11742120;11753430;11786497;11853546;11968001;12120503;12176338;12194018;12496284;12565875;12629551;12724311;1322796;14742685;1527003;15304325;15448129;15718470;15889144;15914509;15951850;16081037;16102047;16182515;16212421;16242307;16268778;16289108;16339447;16415903;16418336;16580177;16702223;16717095;1672265;16753580;16754659;16780920;16871065;16892066;16923326;17081983;17095603;17101212;17130640;17395749;17646429;17900700;17919190;17962409;1825698;18280240;18383439;18434541;1846707;1851174;18515384;18577758;18606873;18703424;18710921;18827341;18936096;19020623;1902575;1905813;19212142;19376773;19398560;19401434;19715408;19723632;19758793;20068231;20670195;21044946;21172430;21725197;23637185;23782177;23802516;24130766;24141704;24714562;25576301;25659125;25675501;26154972;26728094;26811146;27566546;27797339;27852822;28228285;28411811;2841328;28514659;28904123;29242379;29331515;29393594;29557506;29786170;30315122;30429286;30484775;30779550;3086311;31073061;31154438;31205027;31408443;31844290;32037480;32157095;32265295;32296767;32488085;32639031;32673515;32938616;32983136;33592498;33717175;33912179;33968037;34087483;34171305;34185709;34357683;34499618;35051231;35061538;35251023;35580925;36010968;36215666;36284347;36440997;36919698;36970776;37750536;37802294;37938771;38505749;38665916;7492305;7876172;7937899;7989336;8073283;8132675;8190105;8208289;8290554;8521505;8664309;8700127;8733591;8910365;8982657;9087410;9152406;9153422;9305846;9544801;9618465;9620797;9770463;9808756;9924018",
        "class_list": "",
        "function": "Double somatic mutations in CTNNB1 and GNA11 in an aldosterone-producing adenoma. Publication Status: Online-Only, [RefSeq, PubMed]; Early-onset hypertension associated with extensive cutaneous capillary malformations harboring postzygotic variants in GNAQ and GNA11., [RefSeq, PubMed]; GNA11 Variants Identified in Patients with Hypercalcemia or Hypocalcemia., [RefSeq, PubMed]; GNAQ/GNA11 Mosaicism Is Associated with Abnormal Serum Calcium Indices and Microvascular Neurocalcification., [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems., [UniProtKB, UniProtKB]; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:31073061). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:31073061). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:31073061). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:31073061). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:31073061). Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNA11 activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:31073061). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (PubMed:27852822). Together with GNAQ, required for heart development (By similarity). In the respiratory epithelium, transmits OXGR1-dependent signals that lead to downstream intracellular Ca(2+) release and mucocilliary clearance of airborne pathogens., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Papillary Hemangioma Harbors Somatic GNA11 and GNAQ Mutations., [RefSeq, PubMed]; The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O15109;Q14350;Q6IB00",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;2.7.11.10;2.7.11.1;3.6.1.5;3.4.21.5;2.7.11.-;2.7.11.15;2.7.11.16;3.6.1.-;2.7.1.153;2.7.1.137;2.7.10.2;3.6.5.4;3.1.4.11;2.7.11.24;3.6.-.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0070062 extracellular exosome;GO:0005765 lysosomal membrane",
        "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0086100 endothelin receptor signaling pathway;GO:0007165 signal transduction;GO:0007207 phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 18.8,
        "record_id": "P29992-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95395-1",
        "uniprot_id": "GCNT3_HUMAN",
        "mass": 50864.0,
        "length": 438,
        "protein_name": "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3",
        "gene_name": "GCNT3",
        "organism": "Human",
        "refseq_name": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform 1",
        "refseq_ac": "NP_004742",
        "gene_names_uniprotkb": "GCNT3",
        "gene_names_refseq": "C2/4GnT; C24GNT; C2GNT2; C2GNTM; GCNT3; GNTM",
        "protein_names_uniprotkb": "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3; 2.4.1.102; 2.4.1.148; 2.4.1.150; C2/4GnT; C2GnT-M; C2GnT-mucin type; Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase; hC2GnT-M",
        "protein_names_refseq": "C2GnT-mucin type; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform 1; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3; beta1,6-N-acetylglucosaminyltransferase-M; beta1,6GlcNAc-transferase; core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase; hC2GnT-M; mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9245);  (R-HSA-913709)",
        "pathway_count": 2,
        "publication_count": 40,
        "publication_id_list": "10330415;10430883;10753916;11042166;11237011;11283017;11304796;11821425;12600830;12855678;1329093;15486459;15560372;15620693;15864435;16418723;17113861;17303715;18537974;22183981;24643043;28855257;30355927;30524438;30833945;32157095;32203219;32350084;34171305;35051231;35399076;35867813;38369410;7655172;9295285;9394011;9417100;9435216;9915862;9988682",
        "class_list": "glycogene;glycosyltransferase",
        "function": "EGF suppressed C2GnT activity in a time- and dose-dependent fashion, and also suppressed core 4 beta1,6 N-acetylglucosaminyltransferase (C4GnT) activity, [RefSeq, PubMed]; Frequently downregulated in colorectal cancer and suppresses colon cancer cell growth., [RefSeq, PubMed]; Functional analysis of GCNT3 for cell migration and EMT of castration-resistant prostate cancer cells., [RefSeq, PubMed]; GCNT3 regulated MUC13 to promote the development of hepatocellular carcinoma through the GSK3beta/beta-catenin pathway., [RefSeq, PubMed]; GCNT3 was regarded as an oncogene in non-small cell lung cancer, and a target of miR-302b-3p, which regulated cell proliferation, migration and invasion in a GCNT3-dependent manner and E-cadherin, N-cadherin, vimentin, cyclin D1 and p-Erk appeared to be downstream molecules of the miR-302b-3p/GCNT3 pathway., [RefSeq, PubMed]; Global analysis of human glycosyltransferases reveals novel targets for pancreatic cancer pathogenesis. Erratum:[Br J Cancer. 2020 May;122(11):1726. doi: 10.1038/s41416-020-0842-6. PMID: 32286491], [RefSeq, PubMed]; Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Also has I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development., [UniProtKB, PubMed]; LINC00511 enhances LUAD malignancy by upregulating GCNT3 via miR-195-5p. Publication Status: Online-Only, [RefSeq, PubMed]; Results describe the identification of the cis-regulatory elements of human C2GnT-M gene., [RefSeq, PubMed]; This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 686,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "2.4.1.102;2.4.1.150;2.4.1.148;2.4.1.-",
        "go_molecular_function": "GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity;GO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008375 acetylglucosaminyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine",
        "synthesized_glycan_count": 2877,
        "hit_score": 4.1,
        "record_id": "O95395-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P48506-1",
        "uniprot_id": "GSH1_HUMAN",
        "mass": 72766.0,
        "length": 637,
        "protein_name": "Glutamate--cysteine ligase catalytic subunit",
        "gene_name": "GCLC",
        "organism": "Human",
        "refseq_name": "glutamate--cysteine ligase catalytic subunit isoform b",
        "refseq_ac": "NP_001184044",
        "gene_names_uniprotkb": "GCLC; GLCLC; GLCL",
        "gene_names_refseq": "CNSHA7; GCLC; GCL; GCS; GLCLC; GLCL",
        "protein_names_uniprotkb": "Glutamate--cysteine ligase catalytic subunit; 6.3.2.2; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase",
        "protein_names_refseq": "GCS heavy chain; gamma-ECS; gamma-glutamylcysteine synthetase; glutamate--cysteine ligase catalytic subunit isoform b",
        "tax_id": 9606,
        "disease": "congenital nonspherocytic hemolytic anemia 7 (Disease Ontology:DOID:0111681); cystic fibrosis (Disease Ontology:DOID:1485); liver cirrhosis (Disease Ontology:DOID:5082); hemolytic anemia (Disease Ontology:DOID:583); myocardial infarction (Disease Ontology:DOID:5844); cataract (Disease Ontology:DOID:83); colorectal cancer (Disease Ontology:DOID:9256); pulmonary emphysema (Disease Ontology:DOID:9675)",
        "pathway": " (hsa:2729);  (R-HSA-174403);  (R-HSA-5578999);  (R-HSA-9818027)",
        "pathway_count": 4,
        "publication_count": 96,
        "publication_id_list": "10369661;10515893;10706635;10733484;10733945;10821856;11237011;11309284;12234984;12235164;12473676;12506115;12663448;1350904;15448164;15520857;15590625;15728556;16314513;17234762;17924658;17942419;18357469;18515354;18767875;19028565;19109178;19273602;19463;19608619;20068231;20460467;21712391;21775727;22667998;22706990;22995213;23027624;23186163;23682772;24041992;25002527;2573352;25931127;27100828;27653015;27756681;27862975;28832583;28904123;28985506;29242379;29508533;29557506;29632711;29693710;29959055;30833945;31154438;31530632;31597407;31844290;32157095;32284348;32350084;32387766;32601262;32938616;32983136;33043019;33462411;33717175;33774477;33968037;33981976;34171305;34357683;34509645;35051231;35251023;35386070;35580925;36010968;36241641;36359768;37146698;38049865;7646467;7726839;7826375;7959763;8813074;9080;9240432;9516961;9675072",
        "class_list": "",
        "function": "Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Ferroptosis-Related Gene GCLC Is a Novel Prognostic Molecular and Correlates with Immune Infiltrates in Lung Adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Genetic variation at the catalytic subunit of glutamate cysteine ligase contributes to the susceptibility to sporadic colorectal cancer: a pilot study., [RefSeq, PubMed]; Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]., [RefSeq]; H1N1 influenza virus infection through NRF2-KEAP1-GCLC pathway induces ferroptosis in nasal mucosal epithelial cells., [RefSeq, PubMed]; SNORA56-mediated pseudouridylation of 28 S rRNA inhibits ferroptosis and promotes colorectal cancer proliferation by enhancing GCLC translation. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 8,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14399",
        "ec_number_list": "6.3.2.2;2.3.1.48;2.3.1.-",
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0043531 ADP binding;GO:0044877 protein-containing complex binding;GO:0004357 glutamate-cysteine ligase activity",
        "go_cellular_component": "GO:0017109 glutamate-cysteine ligase complex;GO:0005829 cytosol",
        "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0097069 cellular response to thyroxine stimulus;GO:0006536 glutamate metabolic process;GO:0006979 response to oxidative stress;GO:0007584 response to nutrient",
        "synthesized_glycan_count": 0,
        "hit_score": 9.7,
        "record_id": "P48506-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43679-1",
        "uniprot_id": "LDB2_HUMAN",
        "mass": 42793.0,
        "length": 373,
        "protein_name": "LIM domain-binding protein 2",
        "gene_name": "LDB2",
        "organism": "Human",
        "refseq_name": "LIM domain-binding protein 2 isoform b",
        "refseq_ac": "NP_001124306",
        "gene_names_uniprotkb": "LDB2; CLIM1",
        "gene_names_refseq": "CLIM1; LDB-2; LDB1; LDB2",
        "protein_names_uniprotkb": "LIM domain-binding protein 2; CLIM-1; Carboxyl-terminal LIM domain-binding protein 1; LDB-2; LIM domain-binding factor CLIM1",
        "protein_names_refseq": "LIM binding domain 2; LIM domain-binding factor CLIM1; LIM domain-binding factor-2; LIM domain-binding protein 2 isoform b; LIM domain-binding protein 2; carboxyl-terminal LIM domain-binding protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9079)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "11237011;16815859;24925974;25418920;25576301;27846572;29242379;29393594;29557506;29632046;30379171;30429286;31844290;32157095;33592498;33656268;33849822;33968037;35051231;35580925;36010968;36473369;9799849;9853615",
        "class_list": "",
        "function": "Cooperation of LIM domain-binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia., [RefSeq, PubMed]; LDB2 was the most connected gene in a transcription factor regulatory network inferred from transendothelial migration of leukocyte and atherosclerosis module genes in coronary and carotid artery disease macrophages., [RefSeq, PubMed]; LIM-domain binding protein 2 was down-regulated by miRNA-96-5p inhibited the proliferation, invasion and metastasis of lung cancer H1299 cells. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]., [RefSeq]; Transcription cofactor. Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors., [UniProtKB, UniProtKB]; [LIM-domain binding protein 2 regulated by m(6)A modification inhibits lung adenocarcinoma cell proliferation in vitro]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60619;O75480",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019899 enzyme binding;GO:0030274 LIM domain binding;GO:0003712 transcription coregulator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0031252 cell leading edge;GO:0005667 transcription regulator complex",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030334 regulation of cell migration;GO:0043549 regulation of kinase activity",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "O43679-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P17027-1",
        "uniprot_id": "ZNF23_HUMAN",
        "mass": 73059.0,
        "length": 643,
        "protein_name": "Zinc finger protein 23",
        "gene_name": "ZNF23",
        "organism": "Human",
        "refseq_name": "zinc finger protein 23 isoform a",
        "refseq_ac": "NP_001291421",
        "gene_names_uniprotkb": "ZNF23; KOX16; ZNF359; ZNF612",
        "gene_names_refseq": "KOX16; ZNF23; ZNF359; ZNF612; Zfp612",
        "protein_names_uniprotkb": "Zinc finger protein 23; Zinc finger protein 359; Zinc finger protein 612; Zinc finger protein KOX16",
        "protein_names_refseq": "kruppel-like zinc finger factor X31; zinc finger protein 23 (KOX 16); zinc finger protein 23 isoform a; zinc finger protein 32; zinc finger protein 359; zinc finger protein 612",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7571);  (R-HSA-212436)",
        "pathway_count": 2,
        "publication_count": 31,
        "publication_id_list": "10235266;10330177;11237011;11395415;12127974;14519192;15175151;15896744;16606702;16719718;17137575;2163759;2288909;28848158;32157095;32161166;32387766;32938616;33592498;33968037;34030136;34087483;34923485;35254053;35580925;36010968;39894887;8183939;8769649;9637681;9653119",
        "class_list": "",
        "function": "Characterization of ZNF359 and its role in human development, [RefSeq, PubMed]; Ectopic expression of ZNF23 induced cell apoptosis by activation of caspase-3, p27, p53 expression and down-regulation of Bcl-2 through mitochondria-dependent pathway., [RefSeq, PubMed]; May be involved in transcriptional regulation. May have a role in embryonic development., [UniProtKB]; Nucleolar small molecule RNA SNORA75 promotes endometrial receptivity by regulating the function of miR-146a-3p and ZNF23., [RefSeq, PubMed]; Silencing of miR-1246 Induces Cell Cycle Arrest and Apoptosis in Cisplatin-Resistant Ovarian Cancer Cells by Promoting ZNF23 Transcription., [RefSeq, PubMed]; ZNF23 is a new member of KRAB-ZNF superfamily with growth-inhibitory ability and its downregulation may contribute to carcinogenesis, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NDP5;Q96IT3;Q9UG42",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "P17027-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UK73-1",
        "uniprot_id": "FEM1B_HUMAN",
        "mass": 70264.0,
        "length": 627,
        "protein_name": "Protein fem-1 homolog B",
        "gene_name": "FEM1B",
        "organism": "Human",
        "refseq_name": "protein fem-1 homolog B",
        "refseq_ac": "NP_056137",
        "gene_names_uniprotkb": "FEM1B; F1AA; KIAA0396",
        "gene_names_refseq": "F1A-ALPHA; F1AA; FEM1-beta; FEM1B; NEDBES",
        "protein_names_uniprotkb": "Protein fem-1 homolog B; F1A-alpha; FEM1-beta; FEM1b; Fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha",
        "protein_names_refseq": "FEM-1-like death receptor binding protein; fem-1-like death receptor-binding protein alpha; fem-1-like in apoptotic pathway protein alpha; protein fem-1 homolog B",
        "tax_id": 9606,
        "disease": "cleft palate (Disease Ontology:DOID:674); cleft lip (Disease Ontology:DOID:9296); type 2 diabetes mellitus (Disease Ontology:DOID:9352); neurodevelopmental disorder with behavioral, ear, and skeletal abnormalities (MONDO:MONDO:0979245)",
        "pathway": " (hsa:10116);  (R-HSA-8951664)",
        "pathway_count": 2,
        "publication_count": 184,
        "publication_id_list": "10535940;10542291;10597293;10623617;10811609;10878807;10973499;11069780;11237011;11259415;11292861;11292862;11454738;11559703;11585840;11733065;11961546;12101228;12186903;12504025;12504026;12526791;12538644;12609982;12682069;12759363;12816948;14690597;14757770;15282312;15361859;15367669;15537541;15572695;15574592;15601820;15601839;15652483;15688063;15694336;15799966;16171779;16401342;16547496;16647857;16707496;16790436;16943200;17081101;17132228;17183367;17220875;17332328;17497243;17697703;17785452;18093314;18206966;18775313;18776931;18805092;18826954;18851830;18926707;19250909;19321346;19330022;19617556;19748355;21447816;21463634;21778237;21863050;21940857;22306028;22424782;22466964;22537386;22959436;23201271;23333871;23401859;23453757;23481700;23535662;23535663;23563313;23583660;23783831;23912815;23986495;24076122;24076655;24366543;24636985;24714562;24793695;24793696;25314029;25349211;25355947;25531226;25892735;26154972;26344709;26375851;26460955;26632597;26728094;26758079;26811146;26906416;26992070;27030794;27222660;27543614;27565346;27600516;27846572;27920218;28115426;28118078;28228285;28510447;28649982;28832583;28834231;28904123;29153394;29242379;29493099;29557506;29632046;29632711;29779948;29786170;29789417;30315122;30429286;30610225;30833945;31154438;31217245;31222486;31844290;31848261;32005965;32157095;32284348;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33392160;33398168;33398170;33444648;33592498;33691108;33717175;33892462;33912179;33936100;33968037;34087483;34171305;34509645;34561969;35051231;35580925;36010968;36241641;36284347;38360992;38465576;9790970;9887101;9891082",
        "class_list": "",
        "function": "A recurrent missense variant in the E3 ubiquitin ligase substrate recognition subunit FEM1B causes a rare syndromic neurodevelopmental disorder., [RefSeq, PubMed]; FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress., [RefSeq, PubMed]; Structural insights into SMCR8 C-degron recognition by FEM1B., [RefSeq, PubMed]; Structural insights into the ubiquitylation strategy of the oligomeric CRL2[FEM1B] E3 ubiquitin ligase., [RefSeq, PubMed]; Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:33398168, PubMed:33398170). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:33398168, PubMed:33398170). The CRL2(FEM1B) complex specifically recognizes proteins ending with -Gly-Leu-Asp-Arg, such as CDK5R1, leading to their ubiquitination and degradation (PubMed:33398168, PubMed:33398170). Also acts as a regulator of the reductive stress response by mediating ubiquitination of reduced FNIP1: in response to reductive stress, the CRL2(FEM1B) complex specifically recognizes a conserved Cys degron in FNIP1 when this degron is reduced, leading to FNIP1 degradation and subsequent activation of mitochondria to recalibrate reactive oxygen species (ROS) (By similarity). Mechanistically, recognizes and binds reduced FNIP1 through two interface zinc ions, which act as a molecular glue that recruit reduced FNIP1 to FEM1B (By similarity). Promotes ubiquitination of GLI1, suppressing GLI1 transcriptional activator activity (PubMed:24076122). Promotes ubiquitination and degradation of ANKRD37 (By similarity). Promotes ubiquitination and degradation of SLBP (PubMed:28118078). Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis (PubMed:10542291). Also involved in glucose homeostasis in pancreatic islet (By similarity). May also act as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 (PubMed:19330022)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43146",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0005123 death receptor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0006915 apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors",
        "synthesized_glycan_count": 0,
        "hit_score": 18.7,
        "record_id": "Q9UK73-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H8W3-1",
        "uniprot_id": "F204A_HUMAN",
        "mass": 27021.0,
        "length": 233,
        "protein_name": "Protein FAM204A",
        "gene_name": "FAM204A",
        "organism": "Human",
        "refseq_name": "protein FAM204A",
        "refseq_ac": "NP_001128144",
        "gene_names_uniprotkb": "FAM204A; C10orf84",
        "gene_names_refseq": "C10orf84; FAM204A; bA319I23.1",
        "protein_names_uniprotkb": "Protein FAM204A",
        "protein_names_refseq": "protein FAM204A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:63877)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "11237011;16385451;24715725;25576301;26154972;27846572;29557506;30379171;30410026;30429286;31844290;32157095;32502341;32897882;33912179;33981976;35051231;35580925;37217939",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DRC6;Q5T373;Q9H5V5",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q9H8W3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NP95-1",
        "uniprot_id": "FGF20_HUMAN",
        "mass": 23499.0,
        "length": 211,
        "protein_name": "Fibroblast growth factor 20",
        "gene_name": "FGF20",
        "organism": "Human",
        "refseq_name": "fibroblast growth factor 20",
        "refseq_ac": "NP_062825",
        "gene_names_uniprotkb": "FGF20",
        "gene_names_refseq": "FGF-20; FGF20; RHDA2",
        "protein_names_uniprotkb": "Fibroblast growth factor 20; FGF-20",
        "protein_names_refseq": "fibroblast growth factor 20",
        "tax_id": 9606,
        "disease": "renal agenesis (Disease Ontology:DOID:14766); renal hypodysplasia/aplasia 2 (MONDO:MONDO:0014319)",
        "pathway": " (hsa:26281);  (R-HSA-109704);  (R-HSA-1257604);  (R-HSA-1839122);  (R-HSA-1839130);  (R-HSA-190322);  (R-HSA-190371);  (R-HSA-190372);  (R-HSA-190373);  (R-HSA-190375);  (R-HSA-2033519);  (R-HSA-2219530);  (R-HSA-5654219);  (R-HSA-5654221);  (R-HSA-5654227);  (R-HSA-5654228);  (R-HSA-5654687);  (R-HSA-5654688);  (R-HSA-5654689);  (R-HSA-5654693);  (R-HSA-5654695);  (R-HSA-5654699);  (R-HSA-5654700);  (R-HSA-5654704);  (R-HSA-5654706);  (R-HSA-5654710);  (R-HSA-5654712);  (R-HSA-5654719);  (R-HSA-5654720);  (R-HSA-5654726);  (R-HSA-5654727);  (R-HSA-5654732);  (R-HSA-5654733);  (R-HSA-5655253);  (R-HSA-5655302);  (R-HSA-5655332);  (R-HSA-5673001);  (R-HSA-6811558)",
        "pathway_count": 38,
        "publication_count": 262,
        "publication_id_list": "10053006;10191262;10490103;10508167;10574949;10579907;10618369;10629055;10652257;10869344;10913340;10918587;11027663;11032730;11055896;11090077;11121055;11136978;11147812;11157491;11237011;11294897;11297579;11306498;11313946;11353842;11429702;11447289;11463336;11546808;11606067;11689702;11702783;11739186;11781872;11803464;11997436;12009017;12032311;12094235;12112473;12121613;12167717;12419216;12461689;12627230;12660731;12767043;12815057;12974390;1325671;1379698;1381348;14506247;14534538;14613973;14688794;14707138;14715624;14871245;15029211;15050920;15094036;15282208;15324302;15356145;15448205;1545823;15546878;15548653;15598814;15718470;15834429;15863029;15863030;15880580;16091734;16140923;16186508;16339315;16456541;16467200;16507368;16532037;1656221;16597617;16627759;16638743;16647110;16684964;16764984;16844695;16847462;16872596;1697263;1716764;17200115;17227708;17344846;17505008;17525745;17552943;17626883;17698633;17803937;17998941;18056464;18079394;18252210;18317450;18337450;18373495;18381441;18412956;18452557;18552176;18594509;18606717;18754654;18755892;18757403;18757432;18772890;18775330;18829560;18840094;18925875;18985070;1898771;19103595;19133659;19147536;19185485;19187780;19224897;19279408;19381019;19411071;19438505;19564416;19576174;19644473;19652666;19696444;19749790;19805105;19809159;19855393;19920141;19946327;19962665;20058876;20094046;20106510;20117945;20179196;20231295;20338997;20421966;20478380;20522708;20709759;20713702;21102635;21160078;21188471;21317208;21367659;21368164;21372320;21478295;21666749;21668414;21711248;21779497;21779505;21827948;21976531;21984976;21993244;22120714;22188813;22569528;22588880;22589270;22698282;22750304;22802530;22837387;23103841;23175443;23298836;23303910;23443682;23558953;23575685;24588013;24897931;24937142;25219551;25467007;25781681;26085527;28778966;31135801;33947140;34674384;34757019;36255742;38007375;6148751;7543144;7559490;7637810;7647778;7719344;7744773;7773297;7809086;7874169;7935463;7972015;8052307;8264585;8394845;8493579;8589699;8599935;8622701;8640234;8645157;8657148;8663044;8665852;8710374;8754806;8755573;8780727;8798788;8841188;8845844;8939933;9045692;9139660;9154000;9182757;9279753;9299490;9438390;9480847;9502772;9538690;9539778;9604935;9632781;9660748;9700203;9730987;9736715;9857065;9895304;9927426",
        "class_list": "glycogene",
        "function": "Association analysis of SYT11, FGF20, GCH1 rare variants in Parkinson's disease., [RefSeq, PubMed]; FGF20 and PGM2 variants are associated with childhood asthma in family-based whole-genome sequencing studies., [RefSeq, PubMed]; FGF20, FGF9, and FGF16 constitute a subfamily among FGFs. FGF20 is preferentially expressed in colorectal cancer., [RefSeq, PubMed]; FGF20. Review article, [RefSeq, PubMed]; Fibroblast Growth Factor 20 Gene Polymorphism in Parkinson's Disease in Asian Population: A Meta-Analysis. Publication Status: Online-Only, [RefSeq, PubMed]; Glioma cell-derived FGF20 suppresses macrophage function by activating beta-catenin., [RefSeq, PubMed]; Neurotrophic factor that regulates central nervous development and function., [UniProtKB, PubMed]; The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 375,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RPH5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0090722 receptor-receptor interaction;GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm",
        "go_biological_process": "GO:1904340 positive regulation of dopaminergic neuron differentiation;GO:0007165 signal transduction;GO:0007267 cell-cell signaling;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 26.3,
        "record_id": "Q9NP95-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z4H9-1",
        "uniprot_id": "F220A_HUMAN",
        "mass": 28021.0,
        "length": 259,
        "protein_name": "Protein FAM220A",
        "gene_name": "FAM220A",
        "organism": "Human",
        "refseq_name": "protein FAM220A",
        "refseq_ac": "NP_001032240",
        "gene_names_uniprotkb": "FAM220A; C7orf70; SIPAR",
        "gene_names_refseq": "ACPIN1; C7orf70; FAM220A; SIPAR",
        "protein_names_uniprotkb": "Protein FAM220A; STAT3-interacting protein as a repressor",
        "protein_names_refseq": "STAT3-interacting protein as a repressor; acrosomal protein 1; protein FAM220A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84792)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11237011;26026268;28904123;29242379;31844290;34561969;35051231;35251023",
        "class_list": "",
        "function": "Promotes dephosphorylation of transcriptional activator STAT3 by interacting with both STAT3 and protein phosphatase PTPN2. This promotes interaction of PTPN2 with STAT3 and mediates STAT3 dephosphorylation by PTPN2, leading to negative regulation of STAT3 transcriptional activator activity. May be required for spermiogenesis or sperm function., [UniProtKB, UniProtKB]; Results suggest that SIPAR terminates the activation of STAT3 through a dephosphorylation process that is dependent upon interaction with TC45 in the nucleus, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q75ML2;Q8NA52;Q9BRR7",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0001669 acrosomal vesicle",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q7Z4H9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P07911-1",
        "uniprot_id": "UROM_HUMAN",
        "mass": 69761.0,
        "length": 640,
        "protein_name": "Uromodulin",
        "gene_name": "UMOD",
        "organism": "Human",
        "refseq_name": "uromodulin isoform a preproprotein",
        "refseq_ac": "NP_001008390",
        "gene_names_uniprotkb": "UMOD",
        "gene_names_refseq": "ADMCKD2; ADTKD1; FJHN; HNFJ1; HNFJ; MCKD2; THGP; THP; UMOD",
        "protein_names_uniprotkb": "Uromodulin; THP; Tamm-Horsfall urinary glycoprotein",
        "protein_names_refseq": "Tamm-Horsfall urinary glycoprotein; uromodulin isoform a preproprotein; uromucoid",
        "tax_id": 9606,
        "disease": "autosomal dominant tubulointerstitial kidney disease (Disease Ontology:DOID:0060062); autosomal dominant tubulointerstitial kidney disease 1 (Disease Ontology:DOID:0061122); kidney disease (Disease Ontology:DOID:557)",
        "pathway": " (hsa:7369);  (R-HSA-446203)",
        "pathway_count": 2,
        "publication_count": 62,
        "publication_id_list": "11134021;11237011;11470266;12089159;12171918;12471200;12629136;12678917;12900848;1425697;14514716;14531790;14569098;14570709;14688233;15086896;15575003;15983957;16317064;17010121;17074750;18375198;19005207;19835842;20172860;20798515;21060763;2136357;22171320;2249987;22776760;23197950;23988501;24112972;25436415;26673890;26811476;27729211;27862975;2834401;29391424;29557506;29671580;30237853;31154438;31844290;32616672;32815518;33196145;34411563;3453112;3498215;35051231;35273390;37074911;38549605;39455668;6156677;7028707;7072193;9760189;9884403",
        "class_list": "",
        "function": "Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF (PubMed:3498215). Facilitates neutrophil migration across renal epithelia (PubMed:20798515)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals (By similarity). Protects against urinary tract infections by binding to type 1 fimbriated E.coli (PubMed:11134021, PubMed:32616672). Binds to bacterial adhesin fimH which mediates the stable formation of bacterial aggregates, prevents the binding of E.coli to uroplakins UPK1A and UPK1B which act as urothelial receptors for type I fimbriae, and allows for pathogen clearance through micturation (PubMed:11134021, PubMed:32616672). Also promotes aggregation of other bacteria including K.pneumoniae, P.aeruginosa and S.mitis and so may also protect against other uropathogens (PubMed:32616672)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Serum uromodulin associates with kidney function and outcome in a cohort of hospitalised COVID-19 patients. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]., [RefSeq]; UROMODULIN - A LINK BETWEEN SODIUM EXCRETION AND ALTERATION IN CIRCADIAN BLOOD PRESSURE PATTERN IN PREHYPERTENSIVES., [RefSeq, PubMed]; Urinary uromodulin is generated by a conserved C-terminal proteolytic cleavage and retains its entire ZP domain., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 8,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 8,
        "reported_o_glycosites_with_glycan": 9,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 9,
        "total_reported_o_glycosites": 9,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 9,
        "total_o_glycosites": 9,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 72,
        "reported_phosphosites": 0,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 63,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 404,
        "disease_count": 3,
        "glyco_site_count": 18,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KP48;B3KRN9;E9PEA4;Q540J6;Q6ZS84;Q8IYG0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0019864 IgG binding",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005796 Golgi lumen;GO:0005929 cilium",
        "go_biological_process": "GO:0072218 metanephric ascending thin limb development;GO:0008285 negative regulation of cell population proliferation;GO:0050829 defense response to Gram-negative bacterium;GO:0006968 cellular defense response;GO:0007159 leukocyte cell-cell adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 48.5,
        "record_id": "P07911-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WXD5-1",
        "uniprot_id": "GEMI6_HUMAN",
        "mass": 18824.0,
        "length": 167,
        "protein_name": "Gem-associated protein 6",
        "gene_name": "GEMIN6",
        "organism": "Human",
        "refseq_name": "gem-associated protein 6",
        "refseq_ac": "NP_079051",
        "gene_names_uniprotkb": "GEMIN6",
        "gene_names_refseq": "GEMIN6",
        "protein_names_uniprotkb": "Gem-associated protein 6; Gemin-6; SIP2",
        "protein_names_refseq": "SIP2; gem-associated protein 6; gemin-6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79833);  (R-HSA-191859);  (R-HSA-9754678)",
        "pathway_count": 3,
        "publication_count": 71,
        "publication_id_list": "10531003;10556282;10601333;10725331;10851237;11237011;11333016;11714716;11748230;12065586;12095920;12441251;12776181;15939020;16314521;17178713;18691976;18984161;19838190;20068231;23186163;23301498;26375851;26992070;27920218;28649982;28832583;28904123;29493099;29557506;29786170;29789417;30429286;30779550;30833945;31530632;31844290;31848261;32157095;32488085;32680882;32908316;32938616;32983136;32995776;32995777;33080218;33188728;33268501;33298915;33479166;33592498;33691108;33754639;33936100;33968037;33981976;34087483;34171305;34315815;34373319;34624207;34932366;35051231;35452176;35561310;35580925;36241641;36610391;8196654;9845364",
        "class_list": "",
        "function": "GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM, Jul 2002]., [RefSeq]; Gemin6 is a component of the SMN complex that localizes to gems and interacts with several Sm proteins of the spliceosomal snRNPs., [RefSeq, PubMed]; Gemin6 promotes c-Myc stabilisation and non-small cell lung cancer progression via accelerating AURKB mRNA maturation., [RefSeq, PubMed]; The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDP8;Q53SI5;Q8WVB4;Q9H5G6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0032797 SMN complex",
        "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 7.4,
        "record_id": "Q8WXD5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6UXP7-1",
        "uniprot_id": "F151B_HUMAN",
        "mass": 31367.0,
        "length": 276,
        "protein_name": "Protein FAM151B",
        "gene_name": "FAM151B",
        "organism": "Human",
        "refseq_name": "protein FAM151B",
        "refseq_ac": "NP_991111",
        "gene_names_uniprotkb": "FAM151B; PRO28685",
        "gene_names_refseq": "FAM151B; UNQ9217",
        "protein_names_uniprotkb": "Protein FAM151B",
        "protein_names_refseq": "AASA9217; protein FAM151B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:167555)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11237011;12975309;30429286;32387766;32938616;33968037;34509645",
        "class_list": "",
        "function": "Essential for survival of retinal photoreceptor cells., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RRE4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0042461 photoreceptor cell development",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q6UXP7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "D6RGH6-1",
        "uniprot_id": "MCIN_HUMAN",
        "mass": 41720.0,
        "length": 385,
        "protein_name": "Multicilin",
        "gene_name": "MCIDAS",
        "organism": "Human",
        "refseq_name": "multicilin",
        "refseq_ac": "NP_001177716",
        "gene_names_uniprotkb": "MCIDAS; IDAS; MCIN; MCI",
        "gene_names_refseq": "CILD42; IDAS; MCIDAS; MCIN; MCI",
        "protein_names_uniprotkb": "Multicilin; McIdas protein; Multiciliate differentiation and DNA synthesis-associated cell cycle protein; Protein Idas",
        "protein_names_refseq": "multiciliate cell differentiation 1; multicilin; protein Idas",
        "tax_id": 9606,
        "disease": "primary ciliary dyskinesia 42 (Disease Ontology:DOID:0111855)",
        "pathway": " (hsa:345643)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11237011;21543332;24064211;25048963;28834231;31844290;32362381;34569065;36010968",
        "class_list": "",
        "function": "Bi-allelic mutations in MCIDAS and CCNO cause human infertility associated with abnormal gamete transport., [RefSeq, PubMed]; Idas as a novel Geminin binding partner, implicated in cell cycle progression, and a putative regulator of proliferation-differentiation decisions during development., [RefSeq, PubMed]; MCIDAS mutations result in a mucociliary clearance disorder with reduced generation of multiple motile cilia.MCIDAS regulates CCNO and FOXJ1 expression. Publication Status: Online-Only, [RefSeq, PubMed]; The properties of the Idas-Geminin complex suggest it as the functional form of Idas and provide a possible mechanism to modulate Geminin activity, [RefSeq, PubMed]; This gene encodes a member of the geminin family of proteins. The encoded nuclear protein is required for the generation of multiciliated cells in respiratory epithelium. Mutations in this gene cause a rare mucociliary clearance disorder associated with recurring respiratory infections in human patients, known as reduced generation of multiple motile cilia (RGMC). [provided by RefSeq, Sep 2016]., [RefSeq]; Transcription regulator specifically required for multiciliate cell differentiation (PubMed:25048963). Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway (PubMed:25048963). Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1 (PubMed:21543332, PubMed:24064211)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Transcriptional regulation of multiciliated cell differentiation. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JGY3;D6R920;F8KGQ8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0003712 transcription coregulator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body",
        "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:1903251 multi-ciliated epithelial cell differentiation;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007346 regulation of mitotic cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "D6RGH6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WVX9-1",
        "uniprot_id": "FACR1_HUMAN",
        "mass": 59357.0,
        "length": 515,
        "protein_name": "Fatty acyl-CoA reductase 1",
        "gene_name": "FAR1",
        "organism": "Human",
        "refseq_name": "fatty acyl-CoA reductase 1 isoform 2",
        "refseq_ac": "NP_115604",
        "gene_names_uniprotkb": "FAR1; MLSTD2; PRO4981",
        "gene_names_refseq": "CSPSD; FAR1; MLSTD2; PFCRD; SDR10E1",
        "protein_names_uniprotkb": "Fatty acyl-CoA reductase 1; 1.2.1.84; FAR1; Male sterility domain-containing protein 2",
        "protein_names_refseq": "fatty acyl-CoA reductase 1 isoform 2; male sterility domain-containing protein 2; short chain dehydrogenase/reductase family 10E, member 1",
        "tax_id": 9606,
        "disease": "rhizomelic chondrodysplasia punctate type 4 (Disease Ontology:DOID:0081243); spastic paraparesis-cataracts-speech delay syndrome (MONDO:MONDO:0036212)",
        "pathway": " (hsa:84188);  (R-HSA-9640463)",
        "pathway_count": 2,
        "publication_count": 74,
        "publication_id_list": "11237011;12975309;15220348;15220349;15671038;16106050;20071337;24108123;24366607;24714562;24715725;25418920;25439727;25645385;25892735;26024233;26154972;26811146;26992070;27862975;28096191;28218747;28228285;28514659;28832583;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29769354;30429286;30484775;31092671;31217245;31844290;32157095;32265295;32350084;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33239752;33298915;33392160;33592498;33633747;33691108;33717175;33912179;33968037;34171305;34185709;34357683;34509645;34561969;34932366;35051231;35154160;35238077;35318648;35561310;35580925;36010968;36241641;36284347;36581221;37938771",
        "class_list": "",
        "function": "A peroxisomal disorder of severe intellectual disability, epilepsy, and cataracts due to fatty acyl-CoA reductase 1 deficiency., [RefSeq, PubMed]; An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids. Erratum:[Genet Med. 2021 Dec;23(12):2467. doi: 10.1038/s41436-021-01189-8. PMID: 34667295], [RefSeq, PubMed]; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348, PubMed:24108123, PubMed:35238077). It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols (PubMed:20071337, PubMed:24108123, PubMed:33239752). In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis (By similarity) (PubMed:24108123, PubMed:35238077)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols. In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Expression of Far1 increased plasmalogen synthesis in wild-type Chinese hamster ovary cells, strongly suggesting that Far1 is a rate-limiting enzyme for plasmalogen synthesis., [RefSeq, PubMed]; Fatty alcohol synthesis in mammals is accomplished by two fatty acyl-CoA reductase isozymes that are expressed at high levels in tissues known to synthesize wax monoesters and ether lipids, [RefSeq, PubMed]; The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]., [RefSeq]; Wax monoester synthesis in mammals involves a two step biosynthetic pathway catalyzed by fatty acyl-CoA reductase and wax synthase enzymes, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DQW8;Q5CZA3",
        "ec_number_list": "1.2.1.84",
        "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0080019 alcohol-forming very long-chain fatty acyl-CoA reductase activity;GO:0102965 alcohol-forming long-chain fatty acyl-CoA reductase activity",
        "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane",
        "go_biological_process": "GO:0008611 ether lipid biosynthetic process;GO:0046474 glycerophospholipid biosynthetic process;GO:0035336 long-chain fatty-acyl-CoA metabolic process;GO:0010025 wax biosynthetic process;GO:0008610 lipid biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "Q8WVX9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UBZ9-1",
        "uniprot_id": "REV1_HUMAN",
        "mass": 138248.0,
        "length": 1251,
        "protein_name": "Translesion synthesis protein REV1",
        "gene_name": "REV1",
        "organism": "Human",
        "refseq_name": "translesion synthesis protein REV1 isoform 2",
        "refseq_ac": "NP_001032961",
        "gene_names_uniprotkb": "REV1; REV1L",
        "gene_names_refseq": "AIBP80; REV1L; REV1",
        "protein_names_uniprotkb": "Translesion synthesis protein REV1; 2.7.7.-; AIBP80; Alpha integrin-binding protein 80; Molecular adapter protein REV1; REV1 homolog; Rev1-like terminal deoxycytidyl transferase; Reversionless protein 1 homolog; Template-dependent deoxycytidyl transferase REV1",
        "protein_names_refseq": "DNA repair protein REV1; REV1 homolog; REV1, polymerase (DNA directed); REV1- like; alpha integrin-binding protein 80; molecular adapter protein REV1; rev1-like terminal deoxycytidyl transferase; reversionless protein 1 homolog; template-dependent deoxycytidyl transferase REV1; translesion synthesis protein REV1 isoform 2; translesion synthesis protein REV1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51455);  (R-HSA-110312);  (R-HSA-5655862);  (R-HSA-5656121);  (R-HSA-5656169)",
        "pathway_count": 5,
        "publication_count": 105,
        "publication_id_list": "10094488;10536157;10660610;10760286;10801132;10856253;10887153;10984059;11006276;11058110;11237011;11278384;11485998;11711549;11784855;11917024;12145297;12444249;12529368;12584190;12952891;14657033;15189446;15199127;15254543;15475561;15657443;16263170;16344468;16357261;16611994;16819516;17043239;17517887;18242152;18470628;19153606;19170759;19413330;19464298;19492058;20159559;20164194;20660785;20952260;21143968;21628590;22266823;22691049;22700975;22721435;22772988;22859295;22859296;23000965;23143872;23593430;24449906;24648516;24715725;24768535;25576301;26154972;26914252;26982350;26992070;28063628;28228285;28904123;29242379;29393594;29557506;29605689;29632046;29778604;29864443;30315122;30379171;30429286;31844290;32157095;32357974;32387766;32502341;32938616;33141586;33298915;33691108;33717175;33912179;33968037;33981976;34087483;34171305;34508659;34509645;34725419;35051231;35115490;36241641;38612916;38969162;3941892;8658138;8751446",
        "class_list": "",
        "function": "Bifunctional protein involved in the maintenance of genome stability through translesion DNA synthesis (TLS) and antibody diversification via somatic hypermutation (PubMed:16263170, PubMed:23143872). Functions as a molecular adapter protein at stalled DNA replication, coordinating polymerases recruitment, selection, and switching, in a manner independent of its deoxycytidyl transferase activity (PubMed:23143872). At the site of DNA lesion, recruits and mediates the switch between low-fidelity inserter DNA polymerases, such as POLK, that incorporate nucleotides opposite lesions and the extender DNA polymerase zeta complex which continues DNA synthesis from distorted primer termini (PubMed:23143872). In vitro, acts as a template-dependent deoxycytidyl transferase that preferentially incorporates deoxycytidine residues from dCTP to the 3'-end of a DNA primer opposite apurinic/apyrimidinic (AP) site, uracil, undamaged DNA templates (G > A > C > T) and a variety of damaged DNA templates (PubMed:10536157, PubMed:11278384, PubMed:38612916). Opposite template guanine, efficiently incorporates not only dCMP but also non-complementary dGMP and dTMP, with lower efficiency for dAMP, demonstrating low fidelity on undamaged DNA (PubMed:10536157, PubMed:11711549, PubMed:38612916). This catalytic activity has been implicated in somatic hypermutation, likely achieved by incorporation of deoxycytidine opposite abasic sites, generated at cytidines via activation-induced deoxycytidine deaminase (AID)-mediated deamination and uracil DNA glycosylase (UNG) activity, respectively (PubMed:16263170). In addition, exhibits a 5'-deoxyribose-5-phosphate lyase activity in vitro, though its necessity in vivo is not confirmed (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Genetic and physical interactions between Poleta and Rev1 in response to UV-induced DNA damage in mammalian cells. Publication Status: Online-Only, [RefSeq, PubMed]; Loss-of-function mutation of REV1 (p.R704Q) mediates cetuximab primary resistance by activating autophagy in RAS-wild type metastatic colorectal cancer., [RefSeq, PubMed]; REV1 promotes lung tumorigenesis by activating the Rad18/SERTAD2 axis. Publication Status: Online-Only, [RefSeq, PubMed]; REV1-Polzeta maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps., [RefSeq, PubMed]; The Catalytic Activity of Human REV1 on Undamaged and Damaged DNA. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O95941;Q53SI7;Q9C0J4;Q9NUP2",
        "ec_number_list": "2.3.2.23;2.7.7.7;6.2.1.-;2.3.2.27;6.3.2.n3;3.4.19.12;2.7.7.-",
        "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0030674 protein-macromolecule adaptor activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0035861 site of double-strand break",
        "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006281 DNA repair;GO:0016446 somatic hypermutation of immunoglobulin genes;GO:0019985 translesion synthesis;GO:0042276 error-prone translesion synthesis",
        "synthesized_glycan_count": 0,
        "hit_score": 10.8,
        "record_id": "Q9UBZ9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z3U7-1",
        "uniprot_id": "MON2_HUMAN",
        "mass": 190359.0,
        "length": 1717,
        "protein_name": "Protein MON2 homolog",
        "gene_name": "MON2",
        "organism": "Human",
        "refseq_name": "protein MON2 homolog isoform 2",
        "refseq_ac": "NP_001265398",
        "gene_names_uniprotkb": "MON2; KIAA1040; SF21",
        "gene_names_refseq": "MON2",
        "protein_names_uniprotkb": "Protein MON2 homolog; Protein SF21",
        "protein_names_refseq": "MON2 homolog, regulator of endosome-to-Golgi trafficking; protein MON2 homolog isoform 2; protein MON2 homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23041)",
        "pathway_count": 1,
        "publication_count": 91,
        "publication_id_list": "11237011;16219684;16301316;18418388;18452278;18669648;18691976;19691289;20068231;20112406;21450827;23301498;23481700;24285343;24715725;25418920;25469497;25576301;25645385;25892735;26375851;26929215;26992070;27600516;27846572;27920218;28063628;28218747;28228285;28446606;28514659;28649982;28832583;28834231;28860189;28904123;29242379;29331515;29393594;29437277;29493099;29557506;29632046;29632711;29769354;29786170;30213940;30315122;30410026;30429286;30524438;30779550;31154438;31217245;31530632;31844290;31848261;31998317;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32572912;32938616;32983136;33141586;33298915;33392160;33592498;33912179;33968037;34087483;34171305;34185709;34357683;34405274;34509645;34561969;35008409;35051231;35251023;35580925;36010968;36241641;36284347;37217939;38665916",
        "class_list": "",
        "function": "An evolutionary conserved MON2:DOPEY2:ATP9A complex is required for SNX3 retromer mediation of Wntless sorting and Wnt secretion Publication Status: Online-Only, [RefSeq, PubMed]; Depletion of hVps18 or hMon2 reduced the efficient production of infectious HIV-1 virions in human cells., [RefSeq, PubMed]; MicroRNA-133a-5p inhibiting metastatic capacity of renal clear cell carcinoma through regulating MON2., [RefSeq, PubMed]; Mon2 is involved in endosome-to-Golgi trafficking as its depletion accelerated the delivery of furin and CI-M6PR to Golgi after endocytosis. Erratum:[Sci Rep. 2016 Sep 22;6:33619. doi: 10.1038/srep33619. PMID: 27654351] Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation., [UniProtKB, PubMed]; Ysl2p represents an essential, evolutionarily conserved member of a network controlling direct binding and membrane docking of Ggas., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5D8U7;A7E2Y0;B9EGP5;F8VWA6;F8W1Z6;Q86TA2;Q8N3I5;Q8NAI0;Q8NHE2;Q9UPW1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0031901 early endosome membrane",
        "go_biological_process": "GO:0042147 retrograde transport, endosome to Golgi;GO:0006895 Golgi to endosome transport;GO:0006623 protein targeting to vacuole;GO:1905279 regulation of retrograde transport, endosome to Golgi;GO:0015031 protein transport",
        "synthesized_glycan_count": 0,
        "hit_score": 9.4,
        "record_id": "Q7Z3U7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NRP7-1",
        "uniprot_id": "STK36_HUMAN",
        "mass": 143995.0,
        "length": 1315,
        "protein_name": "Serine/threonine-protein kinase 36",
        "gene_name": "STK36",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein kinase 36 isoform 2",
        "refseq_ac": "NP_001230242",
        "gene_names_uniprotkb": "STK36; KIAA1278",
        "gene_names_refseq": "CILD46; FU; STK36",
        "protein_names_uniprotkb": "Serine/threonine-protein kinase 36; 2.7.11.1; Fused homolog",
        "protein_names_refseq": "fused homolog; serine/threonine-protein kinase 36 isoform 2; serine/threonine-protein kinase 36; testicular tissue protein Li 188",
        "tax_id": 9606,
        "disease": "hydrocephalus (Disease Ontology:DOID:10908); primary ciliary dyskinesia (Disease Ontology:DOID:9562); ciliary dyskinesia, primary, 46 (MONDO:MONDO:0030332)",
        "pathway": " (hsa:27148)",
        "pathway_count": 1,
        "publication_count": 51,
        "publication_id_list": "10806483;11237011;15268766;17344846;23481700;24715725;25418920;25576301;25645385;26375851;26992070;27600516;27846572;27920218;28218747;28543983;28832583;28834231;28904123;29242379;29393594;29437277;29632046;29786170;30315122;30429286;31154438;31279575;31844290;31848261;32157095;32161166;32357974;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33592498;33912179;33968037;34211107;35051231;35580925;36010968;36241641;38096226;38184689;39894887",
        "class_list": "",
        "function": "Serine/threonine kinase 36 induced epithelial-mesenchymal transition promotes docetaxel resistance in prostate cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine protein kinase which plays an important role in the smoothened pathway by regulating the activity of GLI transcription factors (PubMed:10806483, PubMed:28543983, PubMed:31279575, PubMed:38096226). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483, PubMed:31279575, PubMed:38096226). Acts by mediating phosphorylation of GLI proteins, promoting their dissociation from SUFU (PubMed:28543983, PubMed:31279575, PubMed:38096226). Also catalyzes phosphorylation of ULK4 adapter (PubMed:38096226). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (PubMed:28543983). Essential for construction of the central pair apparatus of motile cilia (PubMed:28543983)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The FU gene and its genomic structure was identified. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7WPM3;Q8TC32;Q9H9N9;Q9UF35;Q9ULE2",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0001222 transcription corepressor binding;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005930 axoneme;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0009791 post-embryonic development;GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway;GO:0035082 axoneme assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q9NRP7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96GK7-1",
        "uniprot_id": "FAH2A_HUMAN",
        "mass": 34596.0,
        "length": 314,
        "protein_name": "Oxaloacetate tautomerase FAHD2A, mitochondrial",
        "gene_name": "FAHD2A",
        "organism": "Human",
        "refseq_name": "oxaloacetate tautomerase FAHD2A, mitochondrial",
        "refseq_ac": "NP_057128",
        "gene_names_uniprotkb": "FAHD2A; CGI-105",
        "gene_names_refseq": "CGI-105; FAHD2A",
        "protein_names_uniprotkb": "Oxaloacetate tautomerase FAHD2A, mitochondrial; 5.3.2.2; Fumarylacetoacetate hydrolase domain-containing protein 2A",
        "protein_names_refseq": "fumarylacetoacetate hydrolase domain containing 1; fumarylacetoacetate hydrolase domain-containing protein 2A; oxaloacetate tautomerase FAHD2A, mitochondrial",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51011)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "11237011;15551868;20532202;25576301;26992070;27846572;28904123;29242379;29557506;30410026;31217245;32157095;32502341;32938616;33141586;33298915;33691108;33912179;34171305;34211107;34509645;35051231;35580925;36010968;38287013;39894887",
        "class_list": "",
        "function": "Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate (PubMed:38287013). It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition (PubMed:38287013)., [UniProtKB, PubMed]; The X-ray structure of fumarylacetoacetate hydrolase family member FLJ36880 has been determined to 2.2 angstroms resolution employing the semi-automated high-throughput structural genomics approach., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9Y3B0",
        "ec_number_list": "5.3.2.2;3.7.1.5;4.1.1.112",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0050163 oxaloacetate tautomerase activity;GO:0003824 catalytic activity",
        "go_cellular_component": "GO:0005739 mitochondrion",
        "go_biological_process": "GO:0006107 oxaloacetate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q96GK7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P19087-1",
        "uniprot_id": "GNAT2_HUMAN",
        "mass": 40176.0,
        "length": 354,
        "protein_name": "Guanine nucleotide-binding protein G(t) subunit alpha-2",
        "gene_name": "GNAT2",
        "organism": "Human",
        "refseq_name": "guanine nucleotide-binding protein G(t) subunit alpha-2",
        "refseq_ac": "NP_005263",
        "gene_names_uniprotkb": "GNAT2; GNATC",
        "gene_names_refseq": "ACHM4; GNAT2; GNATC; HG1D",
        "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(t) subunit alpha-2; Transducin alpha-2 chain",
        "protein_names_refseq": "cone-type transducin alpha subunit; guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2; guanine nucleotide-binding protein G(t) subunit alpha-2; heterotrimeric guanine nucleotide-binding protein 1D; transducin alpha-2 chain; transducin, cone-specific, alpha polypeptide",
        "tax_id": 9606,
        "disease": "cone-rod dystrophy (Disease Ontology:DOID:0050572); achromatopsia 4 (Disease Ontology:DOID:0110010); color blindness (Disease Ontology:DOID:13399); achromatopsia (Disease Ontology:DOID:13911); McCune Albright syndrome (Disease Ontology:DOID:1858)",
        "pathway": " (hsa:2780);  (R-HSA-4086398);  (R-HSA-418594)",
        "pathway_count": 3,
        "publication_count": 71,
        "publication_id_list": "10380924;10391246;10391247;10395542;10488343;10588714;10777564;10858654;11007482;11015615;11030334;11237011;11563835;12015605;12077706;12086864;12120503;12471263;12482967;12556497;12729560;12975316;14704854;14977528;15494017;15545263;15611108;15712225;15951850;16634148;16880514;16920709;16923326;17426020;17684012;18434541;18456304;18488142;18577758;19177143;1936270;19536106;19851316;21118996;21267001;21903638;22299025;22941947;23151663;23256519;23362848;23416699;23481700;23563607;23632248;23904219;2534964;26590425;2748346;2834384;2841328;29393594;31058429;32203983;32387766;35051231;7937899;8015379;8406495;9073455;9389482",
        "class_list": "",
        "function": "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase., [UniProtKB]; Missense mutations, nonsense mutations, splice mutations, and small deletions and insertions in the affected genes cause achromatopsia., [RefSeq, PubMed]; Single nucleotide polymorphisms in GNAT2 gene is associated with obesity., [RefSeq, PubMed]; Study identified a total 22 different potentially Achromatopsia-causing variants, of which 12 are novel. The mutation spectrum also includes a novel copy number variation, a heterozygous duplication of exon 4, of which the breakpoint matches exactly that of the previously reported exon 4 deletion., [RefSeq, PubMed]; The cone mosaic in GNAT2-ACHM (GNAT2-achromatopsia) is relatively well preserved, potentially allowing for a wide therapeutic window for cone-directed interventions., [RefSeq, PubMed]; The majority (n = 12) of patients were either homozygotes or compound heterozygotes for known achromatopsia alleles, two in CNGB3 (p.T383fsX and p.T296YfsX9) and three in CNGA3 (p.R283Q, p.R427C and p.L527R)., [RefSeq, PubMed]; Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "P19087-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q02153-1",
        "uniprot_id": "GCYB1_HUMAN",
        "mass": 70514.0,
        "length": 619,
        "protein_name": "Guanylate cyclase soluble subunit beta-1",
        "gene_name": "GUCY1B1",
        "organism": "Human",
        "refseq_name": "guanylate cyclase soluble subunit beta-1 isoform 4",
        "refseq_ac": "NP_001278882",
        "gene_names_uniprotkb": "GUCY1B1; GUC1B3; GUCSB3; GUCY1B3",
        "gene_names_refseq": "GC-S-beta-1; GC-SB3; GUC1B3; GUCB3; GUCSB3; GUCY1B1; GUCY1B3",
        "protein_names_uniprotkb": "Guanylate cyclase soluble subunit beta-1; 4.6.1.2; GCS-beta-1; GCS-beta-3; Guanylate cyclase soluble subunit beta-3; Soluble guanylate cyclase small subunit",
        "protein_names_refseq": "GCS-beta-1; GCS-beta-3; guanylate cyclase 1, soluble, beta 3; guanylate cyclase soluble subunit beta-1 isoform 4; guanylate cyclase soluble subunit beta-1; guanylate cyclase soluble subunit beta-3; soluble guanylate cyclase small subunit",
        "tax_id": 9606,
        "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); Alzheimer's disease (Disease Ontology:DOID:10652)",
        "pathway": " (hsa:2983);  (R-HSA-392154);  (R-HSA-445355)",
        "pathway_count": 3,
        "publication_count": 96,
        "publication_id_list": "10991994;11237011;11242081;11457814;11532985;11889009;12048254;1352257;14506282;14627618;15118850;15377279;156362;1680753;17055381;18974361;1930128;19380584;22421042;22778174;23481700;23505436;23783831;23834404;24669844;24715725;24872348;2526655;25576301;25880248;26154972;26362469;26375851;26811146;2764880;27679490;27862975;27920218;28218747;28228285;28514659;28741090;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29443612;29493099;29508533;29557506;29632046;29786170;30315122;30410026;30429286;30779550;31154438;31217245;31530632;31645439;31844290;31848261;31937595;31998317;32157095;32357974;32938616;32983136;33141586;33298915;33430449;33592498;33717175;33912179;33936100;33968037;34171305;34185709;34211107;34405274;34561969;34932366;35051231;35580925;36010968;36284347;3780718;37938771;8858389;9481611;9598563;9600334;9855623",
        "class_list": "",
        "function": "Inflammation in the Human Periodontium Induces Downregulation of the alpha1- and beta1-Subunits of the sGC in Cementoclasts. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Our observations revealed that rs7638A/C polymorphism of GUCY1B3 and the longer telomere length inclined toward adaptation to high altitude., [RefSeq, PubMed]; Results suggest mechanistic insights into the molecular pathway for soluble guanylyl cyclase (sGC) activation., [RefSeq, PubMed]; This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z426;Q86WY5",
        "ec_number_list": "4.6.1.2",
        "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0004383 guanylate cyclase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005829 cytosol;GO:0008074 guanylate cyclase complex, soluble",
        "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0008015 blood circulation;GO:0007263 nitric oxide mediated signal transduction;GO:0071732 cellular response to nitric oxide;GO:0038060 nitric oxide-cGMP-mediated signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 9.7,
        "record_id": "Q02153-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H840-1",
        "uniprot_id": "GEMI7_HUMAN",
        "mass": 14537.0,
        "length": 131,
        "protein_name": "Gem-associated protein 7",
        "gene_name": "GEMIN7",
        "organism": "Human",
        "refseq_name": "gem-associated protein 7",
        "refseq_ac": "NP_001007270",
        "gene_names_uniprotkb": "GEMIN7",
        "gene_names_refseq": "GEMIN7; SIP3",
        "protein_names_uniprotkb": "Gem-associated protein 7; Gemin-7; SIP3",
        "protein_names_refseq": "gem-associated protein 7; gemin-7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79760);  (R-HSA-191859);  (R-HSA-9754678)",
        "pathway_count": 3,
        "publication_count": 65,
        "publication_id_list": "10531003;10556282;10601333;10725331;10851237;11333016;11714716;11748230;12065586;12095920;12441251;12776181;15939020;16314521;17178713;18984161;19838190;20068231;22223895;23186163;25576301;25880248;28228285;28514659;28832583;29242379;29508533;29557506;29632711;30192525;30315122;30779550;30833945;31154438;31222486;31844290;32157095;32357974;32488085;32502341;32680882;32908316;32983136;32995776;32995777;33080218;33188728;33268501;33298915;33479166;33592498;33691108;33754639;34171305;34315815;34373319;34624207;34932366;35051231;35318648;35580925;36241641;36610391;8196654;9845364",
        "class_list": "",
        "function": "Identification and characterization a novel protein component of the survival of motor neurons complex termed Gemin7 using native purified SMN complexes and peptide sequencing by mass spectrometry, [RefSeq, PubMed]; The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP., [UniProtKB, PubMed, PubMed]; The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear 'gems' (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IA34",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0032797 SMN complex",
        "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "Q9H840-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P10124-1",
        "uniprot_id": "SRGN_HUMAN",
        "mass": 17652.0,
        "length": 158,
        "protein_name": "Serglycin",
        "gene_name": "SRGN",
        "organism": "Human",
        "refseq_name": "serglycin isoform 1 precursor",
        "refseq_ac": "NP_001307982",
        "gene_names_uniprotkb": "SRGN; PRG1; PRG",
        "gene_names_refseq": "PPG; PRG1; PRG; SRGN",
        "protein_names_uniprotkb": "Serglycin; Hematopoietic proteoglycan core protein; P.PG; Platelet proteoglycan core protein; Secretory granule proteoglycan core protein",
        "protein_names_refseq": "hematopoetic proteoglycan core peptide; hematopoetic proteoglycan core protein; hematopoietic proteoglycan core protein; p.PG; platelet proteoglycan core protein; proteoglycan 1, secretory granule; proteoglycan protein core for mast cell secretory granule; secretory granule proteoglycan core peptide; secretory granule proteoglycan core protein; serglycin isoform 1 precursor; serglycin proteoglycan",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5552);  (R-HSA-114608)",
        "pathway_count": 2,
        "publication_count": 75,
        "publication_id_list": "11154222;11911826;12388539;1377686;1435334;14630798;15136585;15297306;15777939;16420477;16870619;18292551;18507432;18512783;18991276;21081667;21209280;2180935;23328677;23640497;23719902;24366607;25502872;26375851;27846572;27862975;27920218;2798108;2835370;28467828;28514659;28649982;28832583;28904123;29242379;29317506;29493099;29508533;29557506;30315122;30429286;31154438;31611695;31844290;3214420;32350084;32387766;32938616;32983136;33043033;33141586;33298915;33392160;33592498;33968037;3402609;34078123;34211107;34357683;34433824;34509645;34524427;34556636;34932366;34969735;35051231;35154160;35251023;35580925;38167807;38411026;6457647;8467233;8672555;9321428",
        "class_list": "glycogene",
        "function": "Clinical Significance of Serglycin Expression in Human Breast Cancer Patients., [RefSeq, PubMed]; MiR-26b-5p suppresses chemoresistance in breast cancer by targeting serglycin: Erratum. Correction to:[Anticancer Drugs. 2022 Mar 1;33(3):308-319. doi: 10.1097/CAD.0000000000001268. PMID: 34924500], [RefSeq, PubMed]; Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF and may also regulate protease secretion. Inhibits bone mineralization., [UniProtKB, PubMed, PubMed, PubMed]; SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a Subset of TTF-1-Negative Lung Adenocarcinomas., [RefSeq, PubMed]; Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone. Erratum:[Cell Death Dis. 2025 Sep 5;16(1):670. doi: 10.1038/s41419-025-07629-6. PMID: 40913092] Publication Status: Online-Only, [RefSeq, PubMed]; Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]., [RefSeq]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 6,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 2,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 184,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R4L7;Q5VW06",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0030141 secretory granule;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0016485 protein processing;GO:0006915 apoptotic process;GO:0031214 biomineral tissue development;GO:0033363 secretory granule organization;GO:0033371 T cell secretory granule organization",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "P10124-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y3L5-1",
        "uniprot_id": "RAP2C_HUMAN",
        "mass": 20745.0,
        "length": 183,
        "protein_name": "Ras-related protein Rap-2c",
        "gene_name": "RAP2C",
        "organism": "Human",
        "refseq_name": "ras-related protein Rap-2c isoform 1 precursor",
        "refseq_ac": "NP_001258115",
        "gene_names_uniprotkb": "RAP2C",
        "gene_names_refseq": "RAP2C",
        "protein_names_uniprotkb": "Ras-related protein Rap-2c; 3.6.5.2",
        "protein_names_refseq": "ras-related protein Rap-2c isoform 1 precursor; ras-related protein Rap-2c; small GTPase RAP2C",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57826);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 39,
        "publication_id_list": "11237011;16213650;17447155;20068231;21654843;23481700;23650620;25576301;25645385;26375851;27452731;28228285;28832583;28904123;29242379;29557506;29632711;29789417;30315122;31541458;32157095;32350084;32938616;32983136;33592498;33912179;33936100;33968037;34357683;34676879;34932366;35051231;35251023;35580925;36010968;36214632;36215666;36241641;8692836",
        "class_list": "",
        "function": "MicroRNA-188-5p promotes apoptosis and inhibits cell proliferation of breast cancer cells via the MAPK signaling pathway by targeting Rap2c., [RefSeq, PubMed]; MicroRNA200c3p suppresses intervertebral disc degeneration by targeting RAP2C/ERK signaling., [RefSeq, PubMed]; RAP2C is a novel member of the Ras family, belonging to the Rap branch of small GTPase proteins and may be involved in SRE-mediated gene transcription., [RefSeq, PubMed]; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription., [UniProtKB, PubMed]; The LncRNA LENOX Interacts with RAP2C to Regulate Metabolism and Promote Resistance to MAPK Inhibition in Melanoma., [RefSeq, PubMed]; The protein encoded by this gene is a member of the Ras-related protein subfamily of the Ras GTPase superfamily. Members of this family are small GTPases that act as molecular switches to regulate cellular proliferation, differentiation, and apoptosis. This protein has been reported to activate in vitro transcriptional activity of the serum response element. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]., [RefSeq]; This work demonstrates that Rap2C is a new member of the Rap2 subfamily of proteins, able to bind guanine nucleotides with peculiar properties, and differently expressed by various hematopoietic subsets, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KWD6;Q5H9H9;Q9BTS0",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;3.4.24.81;3.2.1.20;3.6.1.5;3.4.21.73;1.6.3.-;3.1.3.48;3.6.1.-;3.6.5.4;3.4.24.-;7.6.2.1;1.1.1.-;3.1.4.4;2.7.11.1;2.3.2.27;2.3.1.78;3.6.-.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019003 GDP binding;GO:0003925 G protein activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0032486 Rap protein signal transduction;GO:0030336 negative regulation of cell migration;GO:0090557 establishment of endothelial intestinal barrier;GO:0061097 regulation of protein tyrosine kinase activity;GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q9Y3L5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43566-7",
        "uniprot_id": "RGS14_HUMAN",
        "mass": 61447.0,
        "length": 566,
        "protein_name": "Regulator of G protein signaling 14",
        "gene_name": "RGS14",
        "organism": "Human",
        "refseq_name": "regulator of G-protein signaling 14 isoform 1",
        "refseq_ac": "NP_006471",
        "gene_names_uniprotkb": "RGS14",
        "gene_names_refseq": "RGS14",
        "protein_names_uniprotkb": "Regulator of G protein signaling 14; RGS14",
        "protein_names_refseq": "regulator of G-protein signaling 14 isoform 1",
        "tax_id": 9606,
        "disease": "nephrolithiasis (Disease Ontology:DOID:585)",
        "pathway": " (hsa:10636);  (R-HSA-418594)",
        "pathway_count": 2,
        "publication_count": 81,
        "publication_id_list": "11007482;12120503;12534294;15917656;15951850;16634148;16819986;16923326;17603074;17635935;18434541;18577758;19690332;20058876;21115486;22424782;22544926;23481700;24714562;24715725;2534964;25418920;26154972;26375851;26811146;2748346;27846572;27862975;27920218;28218747;28228285;2834384;28514659;28832583;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30410026;30524438;31217245;31844290;32157095;32265295;32350084;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33691108;33717175;33912179;33936100;33968037;34211107;34509645;34932366;35051231;35251023;35307350;35561310;35580925;36010968;36541898;38237897;39293332;7937899;8015379;8406495",
        "class_list": "",
        "function": "Distinct and overlapping RGS14 and RGS12 actions regulate NPT2A-mediated phosphate transport., [RefSeq, PubMed]; Hepatic regulator of G protein signaling 14 ameliorates NAFLD through activating cAMP-AMPK signaling by targeting Gialpha1/3., [RefSeq, PubMed]; RGS14 expression in CA2 hippocampus, amygdala, and basal ganglia: Implications for human brain physiology and disease. Review article, [RefSeq, PubMed]; RGS14 regulates PTH- and FGF23-sensitive NPT2A-mediated renal phosphate uptake via binding to the NHERF1 scaffolding protein., [RefSeq, PubMed]; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerization and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory., [UniProtKB, PubMed, PubMed]; This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43565;Q506M1;Q6ZWA4;Q8TD62",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0001965 G-protein alpha-subunit binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome",
        "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0006979 response to oxidative stress;GO:0007059 chromosome segregation;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007612 learning",
        "synthesized_glycan_count": 0,
        "hit_score": 8.2,
        "record_id": "O43566-7",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y3C5-1",
        "uniprot_id": "RNF11_HUMAN",
        "mass": 17444.0,
        "length": 154,
        "protein_name": "RING finger protein 11",
        "gene_name": "RNF11",
        "organism": "Human",
        "refseq_name": "RING finger protein 11",
        "refseq_ac": "NP_055187",
        "gene_names_uniprotkb": "RNF11; CGI-123",
        "gene_names_refseq": "CGI-123; RNF11; SID1669",
        "protein_names_uniprotkb": "RING finger protein 11",
        "protein_names_refseq": "RING finger protein 11",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26994)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "10673045;14559117;14562029;14755250;16123141;17917589;18615712;18724389;19131965;20213681;20676133;23186163;28063628;28467828;29242379;33592498;33968037;34357683;35038807",
        "class_list": "",
        "function": "Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome., [UniProtKB, PubMed]; Overexpression of RNF11, through its interaction with Smurf2, can restore TGFbeta responsiveness in transfected tumor cells, [RefSeq, PubMed]; The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008]., [RefSeq]; [Mechanism of ring finger protein 11 regulating Akt signaling pathway to promote osteogenic differentiation of bone marrow mesenchymal stem cells]., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 15,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KAI2;Q5T7R8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005769 early endosome;GO:0055037 recycling endosome;GO:0070062 extracellular exosome;GO:0000151 ubiquitin ligase complex",
        "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q9Y3C5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14610-1",
        "uniprot_id": "GBGT2_HUMAN",
        "mass": 7747.0,
        "length": 69,
        "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2",
        "gene_name": "GNGT2",
        "organism": "Human",
        "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2",
        "refseq_ac": "NP_001185683",
        "gene_names_uniprotkb": "GNGT2; GNG8; GNG9; GNGT8",
        "gene_names_refseq": "G-GAMMA-8; G-GAMMA-C; GNG9; GNGT2; GNGT8; HG3I",
        "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2; G gamma-C; G-gamma-8; G-gamma-9; Guanine nucleotide binding protein gamma transducing activity polypeptide 2",
        "protein_names_refseq": "G protein cone gamma 8 subunit; G-gamma-9; g gamma-C; gamma-T2 subunit; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2; guanine nucleotide binding protein gamma 9; guanine nucleotide binding protein gamma transducing activity polypeptide 2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2; heterotrimeric guanine nucleotide-binding protein 3I",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2793);  (R-HSA-1296041);  (R-HSA-202040);  (R-HSA-381676);  (R-HSA-392170);  (R-HSA-392451);  (R-HSA-392851);  (R-HSA-400042);  (R-HSA-4086398);  (R-HSA-416476);  (R-HSA-416482);  (R-HSA-418217);  (R-HSA-418555);  (R-HSA-418592);  (R-HSA-418594);  (R-HSA-418597);  (R-HSA-420092);  (R-HSA-428930);  (R-HSA-432040);  (R-HSA-456926);  (R-HSA-500657);  (R-HSA-6814122);  (R-HSA-8964315);  (R-HSA-8964616);  (R-HSA-9009391);  (R-HSA-9634597);  (R-HSA-9660821);  (R-HSA-9856530);  (R-HSA-997272)",
        "pathway_count": 29,
        "publication_count": 463,
        "publication_id_list": "10191087;10215864;10318832;10319328;10322410;10376603;10380924;10391246;10391247;10395542;10427092;10449730;10488343;10496952;10567430;10588714;10634944;10639123;10649434;10698200;10714768;10727532;10749889;10759852;10764742;10777564;10806474;10858654;10861009;10948191;10954748;11007482;11015615;11029009;11029403;11030334;11034202;11043579;11044445;11060443;11071853;11076974;11185956;11196645;11237011;11283606;11294240;11313909;11313914;11369763;11563835;11689445;11698416;11714923;11742120;11753430;11773440;11773442;11773443;11786497;11825873;11853546;11946536;11968001;11981029;12015605;12034449;12036966;12048194;12058044;12086864;12101119;12106601;12120503;12123608;12167717;12176338;12180353;12180908;12194985;12388769;12401793;12410638;12421825;12431978;12433842;12446735;12471263;12475787;12482967;12496249;12507995;12511868;12515866;12556497;12560222;12588983;12682286;12724311;12729560;12801959;12808053;12860470;12881510;12887923;12938160;12975316;1325798;1333056;1347957;13549488;13680124;1373524;1378832;14514350;14514735;14573771;14592814;14671004;14675202;14701836;14704854;14742685;14764897;14977528;14988243;15033483;15044318;15090535;1510932;1517224;15231873;15245432;15304325;15314172;1534149;15464082;15467163;15471943;15494017;15496458;15539556;15545263;15569269;15569929;15611108;15657067;15699075;15703994;15705661;15705806;15718470;15749160;15765929;15769620;15889144;15951850;15955806;15956360;15980156;15995848;16102047;16120822;16182515;16212421;16212495;16239258;16268778;16274718;16313925;16339447;16352729;16371464;16373322;16407073;16407156;16415903;16418336;1645720;16460020;16580177;16613879;16634148;16636149;16645038;16687412;16702223;16717095;1672265;16754659;16780920;16835357;16880514;16892066;16920709;16923326;16973695;17037979;17095603;17156409;17168849;17178220;17185339;17306374;17379646;1739432;17424910;17426020;17444618;17525128;17535799;17545310;17684012;17900700;17916740;17921256;18044684;18162464;18202100;18202181;18206197;1825698;18287102;18374420;18412318;18434541;18456304;18488142;1849000;18511455;1851174;18515384;18566127;18577758;18657504;18678926;18710921;18729826;18936096;19020623;1905813;19105585;19138696;19144687;19170255;19177143;19212140;19258039;19342380;19342448;19376773;19383790;1939224;19536106;19574955;19715408;19723632;19741198;19851316;19859570;19861722;19876791;19879889;19929708;19931550;20007474;20381629;20439495;20453851;20650261;20655490;20670195;20861220;21036126;21118996;21172430;2163110;21680538;21844907;21851428;21903638;22028449;22031296;22266855;22446104;22480736;22495674;22661716;22941947;23151663;23256519;23416699;23632248;23637185;23904219;24039841;2417744;24273487;24530924;24687066;2474350;2491850;24962572;2534964;25414122;2553411;2553705;25587652;25659125;25675501;26154972;26190834;26308095;26417854;26590425;26987903;27072905;27288742;27392633;2748346;27566546;27797339;27846572;28228285;2826231;2834384;2841328;28450397;28502923;28539435;28595943;2871555;29443750;29557506;29602314;29738483;2991279;30007591;3049610;30833991;3086311;3104109;31205027;3127824;31279028;31399091;3141418;31908393;31983287;32226383;32296767;32497535;32540603;32618402;32639031;32715661;33049737;33066754;34022220;34499618;3899557;4065330;6085243;6192430;6745415;7503232;7510718;7512962;7514139;7526388;7526779;7532011;7535000;7538665;7559455;7567982;7568118;7589426;7589461;7595566;7624799;7641683;7651538;7678419;7680413;7700244;7750475;7811244;7876172;7902709;7937899;8007951;8015379;8063828;8073283;8099279;8138058;8140421;8144028;8208289;8277227;8290554;8340388;8390245;8404634;8405712;8406495;8514797;8521505;8522976;8527267;8554519;8598224;8617235;8621513;8662784;8664309;8672451;8683474;8700127;8702633;8733591;8778232;8782602;8816443;8830891;8855281;8876252;8910365;8982657;8997178;9073455;9087410;9152406;9153422;9173876;9227644;9263355;9286705;9305846;9308960;9369468;9374639;9374640;9389482;9395517;9417641;9488697;9544801;9565625;9616126;9618465;9620797;9651336;9707174;9756892;9760042;9770463;9796816;9829975;9920805;9924018;9990065",
        "class_list": "",
        "function": "Gbetagamma translocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein-coupled receptor signaling to MAPK., [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB, UniProtKB, UniProtKB]; Integrated genomics analysis highlights important SNPs and genes implicated in moderate-to-severe asthma based on GWAS and eQTL datasets. Publication Status: Online-Only, [RefSeq, PubMed]; Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010]., [RefSeq]; Results identify novel functions of beta-arrestin1 in binding to the beta1gamma2 subunits of heterotrimeric G-proteins and promoting G(betagamma)-mediated Akt signalling for NF-kappaB activation., [RefSeq, PubMed]; Survival analysis showed that G protein subunit gamma transducin 2 (GNGT2) was closely related to survival of esophageal cancer. Expression of GNGT2 was evaluated by quantitative real time polymerase chain reaction, and the results showed that GNGT2 expression was significantly upregulated in esophageal cancer patient samples and cell lines, and that GNGT2 could promote the proliferation of esophageal cancer cell lines., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R746;D3DTW5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0003924 GTPase activity",
        "go_cellular_component": "GO:0005834 heterotrimeric G-protein complex",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007602 phototransduction",
        "synthesized_glycan_count": 0,
        "hit_score": 46.4,
        "record_id": "O14610-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P41145-1",
        "uniprot_id": "OPRK_HUMAN",
        "mass": 42645.0,
        "length": 380,
        "protein_name": "Kappa-type opioid receptor",
        "gene_name": "OPRK1",
        "organism": "Human",
        "refseq_name": "kappa-type opioid receptor isoform 1",
        "refseq_ac": "NP_000903",
        "gene_names_uniprotkb": "OPRK1; OPRK",
        "gene_names_refseq": "K-OR-1; KOP; KOR-1; KOR1; KOR; OPRK1; OPRK",
        "protein_names_uniprotkb": "Kappa-type opioid receptor; K-OR-1; KOR-1",
        "protein_names_refseq": "Opiate receptor, kappa-1; kappa opioid receptor; kappa-type opioid receptor isoform 1; kappa-type opioid receptor",
        "tax_id": 9606,
        "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); opioid abuse (Disease Ontology:DOID:11206); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); opiate dependence (Disease Ontology:DOID:2559); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); neonatal abstinence syndrome (Disease Ontology:DOID:9828); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)",
        "pathway": " (hsa:4986);  (R-HSA-375276);  (R-HSA-418594);  (R-HSA-9022699)",
        "pathway_count": 4,
        "publication_count": 123,
        "publication_id_list": "10079109;10100623;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10604470;10854085;10899166;11007482;11237011;11322507;11385580;11457843;11562423;11683476;11773063;12004055;12120503;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;15139756;15539556;15608558;1567413;15947423;15951850;16431922;1655761;16634148;16923326;1710450;1710578;1719979;1722333;17711303;18127230;18434541;1847994;18577758;20401607;20729876;22437504;23446738;23690594;24150225;24906252;2534964;25424712;26214522;2649896;2748346;27496565;2834384;31217245;3202875;3366244;35051231;3525564;37177778;38013468;3856870;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7869844;7905839;7929306;7937899;8015379;8035319;8060324;8062389;8063797;8185599;8201839;8248172;8294032;8373420;8381365;8383682;8395824;8406495;8440682;8463333;8503909;8615752;8666380;8702752;873923;8823230;9171878;9521323;9530155;9593744;9607765;9685625;9722565;9792798;9832121;9851594",
        "class_list": "",
        "function": "Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms., [RefSeq, PubMed]; G protein-coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions., [UniProtKB, UniProtKB]; Kappa-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-kappaB pathway., [RefSeq, PubMed]; OPKR1 structure and association of haplotypes with opiate addiction was found to have empirical significance. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 2,
        "mined_n_glycosites": 2,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 13,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E5RHC9;Q499G4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0038048 dynorphin receptor activity;GO:0033612 receptor serine/threonine kinase binding;GO:0042923 neuropeptide binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0043204 perikaryon",
        "go_biological_process": "GO:1904000 positive regulation of eating behavior;GO:0006955 immune response;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0007626 locomotory behavior",
        "synthesized_glycan_count": 0,
        "hit_score": 12.6,
        "record_id": "P41145-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y3P9-1",
        "uniprot_id": "RBGP1_HUMAN",
        "mass": 121737.0,
        "length": 1069,
        "protein_name": "Rab GTPase-activating protein 1",
        "gene_name": "RABGAP1",
        "organism": "Human",
        "refseq_name": "rab GTPase-activating protein 1",
        "refseq_ac": "NP_036329",
        "gene_names_uniprotkb": "RABGAP1; HSPC094",
        "gene_names_refseq": "GAPCENA; RABGAP1; TBC1D11",
        "protein_names_uniprotkb": "Rab GTPase-activating protein 1; GAP and centrosome-associated protein; Rab6 GTPase-activating protein GAPCenA",
        "protein_names_refseq": "GAP and centrosome-associated protein; Rab6 GTPase activating protein, GAPCenA; TBC1 domain family, member 11; rab GTPase-activating protein 1; rab6 GTPase activating protein (GAP and centrosome-associated); rab6 GTPase-activating protein GAPCenA",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23637);  (hsa:2844);  (R-HSA-8854214)",
        "pathway_count": 3,
        "publication_count": 85,
        "publication_id_list": "10202141;11237011;16055087;16395330;17658474;17901050;18199687;18319245;18466115;18669648;18767875;19077034;19651622;20068231;20095038;20116244;20363736;20404108;21383079;21458671;22219378;22613832;22762500;22795129;22854040;23019362;23186163;23248241;23301498;23481700;23562278;25548167;25576301;25645385;25880248;25892735;26154972;26992070;27726376;27846572;27862975;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29314611;29393594;29493099;29557506;29632046;30315122;30410026;30429286;31217245;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33537174;33592498;33717175;33912179;33936100;33968037;34171305;34357683;34561969;34725712;35051231;35251023;35580925;36010968;36241641",
        "class_list": "",
        "function": "May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition., [UniProtKB, PubMed, PubMed]; Suggest that EPI64A and B, which are ubiquitously expressed members of the EPI64 subfamily, inactivate Ras and certain Rabs at the periphery of cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9A6L2;Q05CW2;Q6ZMY1;Q9HA28;Q9P0E2;Q9UG67",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0015631 tubulin binding;GO:0004930 G protein-coupled receptor activity",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005875 microtubule associated complex;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0043087 regulation of GTPase activity",
        "synthesized_glycan_count": 0,
        "hit_score": 8.8,
        "record_id": "Q9Y3P9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P14222-1",
        "uniprot_id": "PERF_HUMAN",
        "mass": 61377.0,
        "length": 555,
        "protein_name": "Perforin-1",
        "gene_name": "PRF1",
        "organism": "Human",
        "refseq_name": "perforin-1 precursor",
        "refseq_ac": "NP_001076585",
        "gene_names_uniprotkb": "PRF1; PFP",
        "gene_names_refseq": "HPLH2; P1; PFP; PRF1",
        "protein_names_uniprotkb": "Perforin-1; Cytolysin; Lymphocyte pore-forming protein; P1; PFP",
        "protein_names_refseq": "cytolysin; lymphocyte pore-forming protein; perforin 1 (pore forming protein); perforin-1 precursor",
        "tax_id": 9606,
        "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); familial hemophagocytic lymphohistiocytosis 2 (Disease Ontology:DOID:0110922); aplastic anemia (Disease Ontology:DOID:12449); Fanconi anemia (Disease Ontology:DOID:13636); colon carcinoma (Disease Ontology:DOID:1520); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); glomerulonephritis (Disease Ontology:DOID:2921); non-Langerhans-cell histiocytosis (Disease Ontology:DOID:4330); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); chronic fatigue syndrome (Disease Ontology:DOID:8544); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 1 diabetes mellitus (Disease Ontology:DOID:9744)",
        "pathway": " (hsa:5551);  (R-HSA-9725371)",
        "pathway_count": 2,
        "publication_count": 67,
        "publication_id_list": "10583959;11169414;11179007;11237011;11751994;12748172;16009132;16959974;17110082;17111047;17416736;17690253;17922009;18024471;18097461;19159218;20015877;20038786;20225066;20493732;20889983;21037563;21715655;22424782;22955283;23734337;2395434;24060861;24088571;24190977;24558045;2480391;25818168;2592021;26154972;26992070;27553022;27862975;28757574;28904123;29317506;29493099;29557506;29588546;30692217;31366041;31390744;31434245;31844290;32299851;32350084;32357974;32983136;33912179;3419519;34357683;35051231;35251023;35580925;36241641;37074911;37149695;37390248;8676885;9058810;9164947;9930702",
        "class_list": "",
        "function": "Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Familial hemophagocytic phohistiocytosis induced by PRF1 mutation with neurologic manifestations as the initial clinical presentations: A case report., [RefSeq, PubMed]; Pore-forming protein that plays a key role in granzyme-mediated programmed cell death, and in defense against virus-infected or neoplastic cells (PubMed:20889983, PubMed:21037563, PubMed:24558045, PubMed:9058810, PubMed:9164947). Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease (PubMed:9058810). Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores (PubMed:20889983, PubMed:21037563). Promotes cytolysis and apoptosis of target cells by mediating the passage and uptake of cytotoxic granzymes (PubMed:20038786, PubMed:20225066, PubMed:24558045, PubMed:32299851). Facilitates the delivery of cationic cargo protein, while anionic or neural proteins are not delivered efficiently (PubMed:24558045). Perforin pores allow the release of mature caspase-7 (CASP7) into the extracellular milieu (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Study focuses on the role of perforin in both protecting and promoting human disease. It concludes with a novel hypothesis that diversity observed in the PRF1 gene may be an example of selective advantage that protects an individual from perforin-mediated pathology, such as blood-brain barrier disruption. [review] Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 9507,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 15,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6X4;Q59F57;Q86WX7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0022829 wide pore channel activity;GO:0140911 pore-forming activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031904 endosome lumen;GO:0001772 immunological synapse",
        "go_biological_process": "GO:0051712 positive regulation of killing of cells of another organism;GO:0002418 immune response to tumor cell;GO:0051260 protein homooligomerization;GO:0051607 defense response to virus;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.3,
        "record_id": "P14222-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y219-1",
        "uniprot_id": "JAG2_HUMAN",
        "mass": 133367.0,
        "length": 1238,
        "protein_name": "Protein jagged-2",
        "gene_name": "JAG2",
        "organism": "Human",
        "refseq_name": "protein jagged-2 isoform a precursor",
        "refseq_ac": "NP_002217",
        "gene_names_uniprotkb": "JAG2",
        "gene_names_refseq": "HJ2; JAG2; LGMDR27; SER2",
        "protein_names_uniprotkb": "Protein jagged-2; Jagged2; hJ2",
        "protein_names_refseq": "jagged 2; jagged-2 protein; protein jagged-2 isoform a precursor; protein jagged-2",
        "tax_id": 9606,
        "disease": "autosomal recessive limb-girdle muscular dystrophy type 27 (Disease Ontology:DOID:0061133); dilated cardiomyopathy (Disease Ontology:DOID:12930)",
        "pathway": " (hsa:3714);  (R-HSA-2122948);  (R-HSA-2644606);  (R-HSA-2660826);  (R-HSA-2691232);  (R-HSA-2894862);  (R-HSA-2979096);  (R-HSA-9013507)",
        "pathway_count": 8,
        "publication_count": 111,
        "publication_id_list": "10.1101/2023.09.13.557529;10079256;10206645;10551863;10662552;10713164;10879540;10882063;10934472;10958687;10964718;11006133;11044625;11171333;11226752;11518718;11740940;11823422;11861489;12050117;12209127;12354787;12391150;12530964;14567914;14980219;15107403;15533827;15546612;15569487;15574878;15652348;15760269;15824097;15829515;15965470;16093323;16284625;16530044;16738328;16773578;17003037;17028573;17114293;17401372;17646408;17646409;18043734;18077452;18237417;18296446;1831692;18374649;1840698;18418349;18469519;18628966;18700817;18824583;18824585;19000840;19151708;19208840;19524514;19567869;19726682;19840942;20156974;20972443;21632553;22162134;22658935;22658936;23186163;24715725;24842903;25125655;25356737;25576301;26992070;29856954;29856955;3153318;32350084;33861953;34087483;35051231;35251023;36010968;36215666;38575576;38636522;38750026;39121631;7566092;7588063;803282;8313469;9207787;9207788;9244301;9315665;9384573;9462510;9486542;9590294;9604939;9620803;9651681;9694793;9819428",
        "class_list": "",
        "function": "Jag1/2 maintain esophageal homeostasis and suppress foregut tumorigenesis by restricting the basal progenitor cell pool. Publication Status: Online-Only, [RefSeq, PubMed]; Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages., [RefSeq, PubMed]; Ovarian tumor cell-derived JAGGED2 promotes omental metastasis through stimulating the Notch signaling pathway in the mesothelial cells. Publication Status: Online-Only, [RefSeq, PubMed]; Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity)., [UniProtKB]; The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Three novel missense variants in two families with JAG2-associated limb-girdle muscular dystrophy., [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 1,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 1,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 54,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UE17;Q9UE99;Q9UNK8;Q9Y6P9;Q9Y6Q0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding;GO:0008083 growth factor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0045061 thymic T cell selection;GO:0007219 Notch signaling pathway;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0042127 regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 11.7,
        "record_id": "Q9Y219-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0CG33-1",
        "uniprot_id": "GOG6D_HUMAN",
        "mass": 79896.0,
        "length": 693,
        "protein_name": "Golgin subfamily A member 6D",
        "gene_name": "GOLGA6D",
        "organism": "Human",
        "refseq_name": "golgin subfamily A member 6D",
        "refseq_ac": "NP_001138696",
        "gene_names_uniprotkb": "GOLGA6D",
        "gene_names_refseq": "GOLGA6D",
        "protein_names_uniprotkb": "Golgin subfamily A member 6D",
        "protein_names_refseq": "golgi autoantigen, golgin subfamily a, 6D; golgin subfamily A member 6D; putative golgin subfamily A member 6D",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:653643)",
        "pathway_count": 1,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0032580 Golgi cisterna membrane;GO:0005801 cis-Golgi network;GO:0000137 Golgi cis cisterna",
        "go_biological_process": "GO:0007030 Golgi organization",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "P0CG33-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14257-1",
        "uniprot_id": "RCN2_HUMAN",
        "mass": 36876.0,
        "length": 317,
        "protein_name": "Reticulocalbin-2",
        "gene_name": "RCN2",
        "organism": "Human",
        "refseq_name": "reticulocalbin-2 isoform b precursor",
        "refseq_ac": "NP_001258766",
        "gene_names_uniprotkb": "RCN2; ERC55",
        "gene_names_refseq": "E6BP; ERC-55; ERC55; RCN2; TCBP49",
        "protein_names_uniprotkb": "Reticulocalbin-2; Calcium-binding protein ERC-55; E6-binding protein; E6BP",
        "protein_names_refseq": "E6-binding protein; calcium-binding protein ERC-55; reticulocalbin 2, EF-hand calcium binding domain (endoplasmic reticulum calcium-binding protein, 55kD); reticulocalbin-2 isoform b precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5955)",
        "pathway_count": 1,
        "publication_count": 51,
        "publication_id_list": "11237011;12816978;23186163;23481700;24715725;25418920;25645385;25810538;26154972;27452731;27726376;27846572;27920218;28649982;28834231;28904123;29242379;29393594;29557506;29786170;29789417;30429286;31611695;31844290;32157095;32265295;32350084;32387766;32502341;32938616;33141586;33298915;33592498;33691108;33717175;33936100;33968037;34087483;34171305;34774078;35051231;35138101;35251023;35318648;35406670;35561310;36215666;36952101;38665916;40914422;8034671",
        "class_list": "",
        "function": "Long non-coding RNA DUXAP8 elevates RCN2 expression and facilitates cell malignant behaviors and angiogenesis in cervical cancer via sponging miR-1297. Publication Status: Online-Only, [RefSeq, PubMed]; Not known. Binds calcium., [UniProtKB]; RCN2 promotes Nasopharyngeal carcinoma progression by curbing Calcium flow and Mitochondrial apoptosis., [RefSeq, PubMed]; Reticulocalbin 2 as a Potential Biomarker and Therapeutic Target for Atherosclerosis. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. This gene maps to the same region as type 4 Bardet-Biedl syndrome, suggesting a possible causative role for this gene in the disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MTG6;F8WCY5;Q53XN8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q14257-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43194-1",
        "uniprot_id": "GPR39_HUMAN",
        "mass": 51329.0,
        "length": 453,
        "protein_name": "G protein-coupled receptor 39",
        "gene_name": "GPR39",
        "organism": "Human",
        "refseq_name": "G-protein coupled receptor 39",
        "refseq_ac": "NP_001499",
        "gene_names_uniprotkb": "GPR39",
        "gene_names_refseq": "GPR39; ZnR",
        "protein_names_uniprotkb": "G protein-coupled receptor 39",
        "protein_names_refseq": "G-protein coupled receptor 39; zinc sensing receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2863);  (R-HSA-373076);  (R-HSA-416476);  (R-HSA-418555)",
        "pathway_count": 4,
        "publication_count": 121,
        "publication_id_list": "10191087;10567430;10727532;10861009;11007482;11015615;11742120;11753430;12036966;12058044;12106601;12120503;12180353;12522134;12524422;12860470;12955148;13549488;14617636;14671004;15141213;1517224;15280385;15326175;15383539;15765929;15769620;15929991;15951850;16182515;16268778;16313925;16339447;16540462;1656963;16687412;16754659;16754668;16844083;16923326;16959833;17054911;17139494;17168849;17339491;17462861;17876302;18044684;18180304;18434541;18515384;18577758;18588883;18693759;18936096;1905813;19105585;19876791;19929708;20381629;20522546;21036126;2163110;21796212;2263478;23186163;2417744;24687066;2491850;2553411;2553705;26365466;26417854;2841328;2871555;29443750;29557506;29602314;30833991;3086311;3127824;31279028;31399091;31844290;31983287;32226383;32497535;32540603;32618402;32715661;32938616;33049737;33592498;33968037;34171305;34185709;35051231;35580925;36010968;36574661;36942516;38049010;38306424;39046409;6085243;7498464;7568007;7689702;7775459;7937899;7946354;8340388;8514797;8664309;8672451;9263355;9305846;9417641;9441746;9651336;9770463",
        "class_list": "",
        "function": "Could activate GPR39 by high concentrations of Zn(2+), demonstrating cell surface expression of a functional receptor that could elicit a Ca(2+) response., [RefSeq, PubMed]; GPR39 is probably not the obestatin receptor, [RefSeq, PubMed]; GPR39 regulated spinal glycinergic inhibition and mechanical inflammatory pain., [RefSeq, PubMed]; Ghrelin receptor, neurotensin receptor 2 and GPR39 display an unusually high degree of constitutive activity, determined by an aromatic cluster on the inner face of the extracellular ends of TMs VI and VII, [RefSeq, PubMed]; Inhibition of GPR39 restores defects in endothelial cell-mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis., [RefSeq, PubMed]; Signaling pathway mechanisms of neurological diseases induced by G protein-coupled receptor 39. Review article, [RefSeq, PubMed]; This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression. [provided by RefSeq, Jun 2016]., [RefSeq]; Zinc-sensing receptor activation induces endothelium-dependent hyperpolarization-mediated vasorelaxation of arterioles., [RefSeq, PubMed]; Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death (PubMed:18180304). Activation by Zn(2+) in keratinocytes increases the intracellular concentration of Ca(2+) and activates the ERK/MAPK and PI3K/AKT signaling pathways leading to epithelial repair (PubMed:20522546). Plays an essential role in normal wound healing by inducing the production of cytokines including the major inflammatory cytokine IL6 via the PKC/MAPK/CEBPB pathway (By similarity). Regulates adipose tissue metabolism, especially lipolysis, and regulates the function of lipases, such as hormone-sensitive lipase and adipose triglyceride lipase (By similarity). Plays a role in the inhibition of cell death and protects against oxidative, endoplasmic reticulum and mitochondrial stress by inducing secretion of the cytoprotective pigment epithelium-derived growth factor (PEDF) and probably other protective transcripts in a GNA13/RHOA/SRE-dependent manner (PubMed:18180304). Forms dynamic heteroreceptor complexes with HTR1A and GALR1 depending on cell type or specific physiological states, resulting in signaling diversity: HTR1A-GPR39 shows additive increase in signaling along the serum response element (SRE) and NF-kappa-B pathways while GALR1 acts as an antagonist blocking SRE (PubMed:26365466)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; [Expressions of zinc homeostasis proteins, GPR39 and ANO1 mRNA in the sperm of asthenozoospermia patients and their clinical significance]., [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 32,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RC12;B6V9G4;Q08AS2;Q53R01",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 12.2,
        "record_id": "O43194-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96ND0-1",
        "uniprot_id": "MIMS1_HUMAN",
        "mass": 30777.0,
        "length": 272,
        "protein_name": "Mitochondrial inner membrane scaffold 1",
        "gene_name": "MIMS1",
        "organism": "Human",
        "refseq_name": "protein FAM210A",
        "refseq_ac": "NP_001092271",
        "gene_names_uniprotkb": "MIMS1; C18orf19; FAM210A",
        "gene_names_refseq": "C18orf19; FAM210A; HsT2329; MIMS1",
        "protein_names_uniprotkb": "Mitochondrial inner membrane scaffold 1; Protein FAM210A",
        "protein_names_refseq": "family with sequence similarity 210 member A; protein FAM210A; uncharacterized protein C18orf19",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:125228)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "11237011;16959974;20068231;20877624;21654843;22453275;25502872;26992070;28904123;29242379;29557506;29618611;30429286;31844290;31998317;32488085;32938616;33141586;33298915;33392160;33592498;34087483;34357683;35051231;35580925;37907737",
        "class_list": "",
        "function": "Circular RNA cFAM210A, degradable by HBx, inhibits HCC tumorigenesis by suppressing YBX1 transactivation., [RefSeq, PubMed]; Genetic variation near FAM210A, a gene of previously unknown function, was strongly associated with both appendicular and whole body lean mass, as well as bone mineral density., [RefSeq, PubMed]; May play a role in the structure and strength of both muscle and bone., [UniProtKB, UniProtKB, UniProtKB]; Mitochondrial inner membrane protein essential for mitochondrial homeostasis, structural integrity, and cellular metabolism. Regulates mitochondrial translation by modulating protein synthesis of mitochondrial DNA-encoded genes. Plays a critical role in skeletal muscle mass and strength by regulating mitochondrial density, function, and protein synthesis. In brown adipose tissue, regulates mitochondrial cristae remodeling in response to cold stress by interacting with mitochondrial protease YME1L1 and enhancing its proteolytic activity, promoting OMA1 degradation and regulating OPA1 processing. Required for cardiac mitochondrial homeostasis and normal cardiomyocyte contractile function. In skeletal muscle, positively regulates myoblast differentiation by enhancing expression of myogenic factors., [UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DUJ4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "Q96ND0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BU20-1",
        "uniprot_id": "CPLN2_HUMAN",
        "mass": 28498.0,
        "length": 258,
        "protein_name": "Ciliogenesis and planar polarity effector 2",
        "gene_name": "CPLANE2",
        "organism": "Human",
        "refseq_name": "ciliogenesis and planar polarity effector 2",
        "refseq_ac": "NP_112169",
        "gene_names_uniprotkb": "CPLANE2; C1orf89; RSG1",
        "gene_names_refseq": "C1orf89; CPLANE2; RSG1",
        "protein_names_uniprotkb": "Ciliogenesis and planar polarity effector 2; REM2- and Rab-like small GTPase 1",
        "protein_names_refseq": "REM2 and RAB like small GTPase 1; REM2- and Rab-like small GTPase 1; Rem/Rab-Similar GTPase 1; ciliogenesis and planar polarity effector 2; miro domain-containing protein C1orf89",
        "tax_id": 9606,
        "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); VACTERL association (Disease Ontology:DOID:14679)",
        "pathway": " (hsa:79363)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "11237011;23481700;24366607;26992070;27717682;27920218;28063628;28228285;28832583;28834231;28904123;29038301;29557506;29632046;30429286;31844290;32157095;32265295;32387766;33298915;34171305;34509645;35051231;35427153;35580925",
        "class_list": "",
        "function": "Required for efficient primary cilia initiation, regulating a late step in cilia initiation. Plays a role in the final maturation of the mother centriole and ciliary vesicle that allows extension of the ciliary axoneme., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5TEV7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding",
        "go_cellular_component": "GO:0005814 centriole;GO:0036064 ciliary basal body;GO:0097546 ciliary base;GO:0035869 ciliary transition zone",
        "go_biological_process": "GO:0015031 protein transport;GO:0060271 cilium assembly;GO:0008104 intracellular protein localization;GO:0006887 exocytosis;GO:0031338 regulation of vesicle fusion",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q9BU20-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P30679-1",
        "uniprot_id": "GNA15_HUMAN",
        "mass": 43508.0,
        "length": 374,
        "protein_name": "Guanine nucleotide-binding protein subunit alpha-15",
        "gene_name": "GNA15",
        "organism": "Human",
        "refseq_name": "guanine nucleotide-binding protein subunit alpha-15",
        "refseq_ac": "NP_002059",
        "gene_names_uniprotkb": "GNA15; GNA16",
        "gene_names_refseq": "GNA15; GNA16; HG1L",
        "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit alpha-15; Epididymis tissue protein Li 17E; G alpha-15; G alpha-16; G protein subunit alpha-15; G protein subunit alpha-16; Guanine nucleotide-binding protein subunit alpha-16",
        "protein_names_refseq": "G-protein subunit alpha-16; epididymis secretory sperm binding protein; epididymis tissue protein Li 17E; g alpha-15; g alpha-16; guanine nucleotide binding protein (G protein), alpha 15 (Gq class); guanine nucleotide-binding protein subunit alpha-15; guanine nucleotide-binding protein subunit alpha-16; heterotrimeric guanine nucleotide-binding protein 1L",
        "tax_id": 9606,
        "disease": "McCune Albright syndrome (Disease Ontology:DOID:1858)",
        "pathway": " (hsa:2769);  (R-HSA-112043);  (R-HSA-202040);  (R-HSA-399997);  (R-HSA-416476);  (R-HSA-418592);  (R-HSA-428930);  (R-HSA-434316);  (R-HSA-456926);  (R-HSA-6814122)",
        "pathway_count": 10,
        "publication_count": 113,
        "publication_id_list": "10191087;10215864;10567430;10727532;10759852;10861009;11015615;11118617;11237011;11588141;11742120;11753430;11786497;12120503;12194018;12496284;12565875;12629551;12748287;1322796;14742685;1527003;15448129;15889144;15914509;15951850;16081037;16102047;16182515;16212421;16242307;16268778;16289108;16339447;16415903;16418336;16580177;16702223;16717095;1672265;16753580;16754659;16871065;16892066;16923326;17081983;17095603;17101212;17130640;17395749;17900700;17919190;17962409;1825698;18383439;18434541;1846707;1851174;18515384;18577758;18606873;18827341;18936096;1905813;19212142;19376773;19398560;19401434;19715408;19758793;20639119;20670195;20736409;21172430;23200847;23637185;24130766;24204697;25659125;25675501;25701539;2841328;28421075;30779550;3086311;31092671;31154438;31848261;31937595;32639031;36642112;38333922;7937899;7989336;8073283;8132675;8190105;8208289;8290554;8521505;8664309;8733591;8910365;8982657;9087410;9152406;9153422;9305846;9544801;9618465;9770463;9808756;9924018",
        "class_list": "",
        "function": "Data indicate the importance of Galpha16 as a downstream effector of the non-canonical Wnt signaling pathway and as a potential therapeutic target for the treatment of non small cell lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Exosomal miR-211-5p regulates glucose metabolism, pyroptosis, and immune microenvironment of melanoma through GNA15., [RefSeq, PubMed]; G15 ectopic presence could functionally contribute to the transformation process since siRNA-induced depletion of Galpha15 in pancreatic carcinoma cell lines dramatically inhibited anchorage-independent growth and resistance to the lack of nutrients., [RefSeq, PubMed]; GNA15 facilitates the malignant development of thyroid carcinoma cells via the BTK-mediated MAPK signaling pathway., [RefSeq, PubMed]; GNA15 was not expressed in normal neuroendocrine cells but was overexpressed in gastroenteropancreatic neuroendocrine neoplasia cell lines., [RefSeq, PubMed]; Member of the G protein alpha subunit family that plays a crucial role in intracellular signaling. Functions as a molecular switch, transducing signals from G protein-coupled receptors (GPCRs) to downstream effectors. In collaboration with the adapter protein TTC1, promotes HRAS activation and ERK1/2 phosphorylation independently of phospholipase Cbeta signaling (PubMed:12748287, PubMed:20639119). Also initiates EMR2-mediated signaling, leading to activation of Akt, MAPK, and NF-kappa-B, which in turn drives macrophage differentiation and inflammatory responses (PubMed:28421075)., [UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9KL40;E9KL47;O75247;Q53XK2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0005834 heterotrimeric G-protein complex",
        "go_biological_process": "GO:0007207 phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway;GO:0019722 calcium-mediated signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 11.4,
        "record_id": "P30679-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P13284-1",
        "uniprot_id": "GILT_HUMAN",
        "mass": 27964.0,
        "length": 250,
        "protein_name": "Gamma-interferon-inducible lysosomal thiol reductase",
        "gene_name": "IFI30",
        "organism": "Human",
        "refseq_name": "gamma-interferon-inducible lysosomal thiol reductase preproprotein",
        "refseq_ac": "NP_006323",
        "gene_names_uniprotkb": "IFI30; GILT; IP30",
        "gene_names_refseq": "GILT; IFI-30; IFI30; IP-30; IP30",
        "protein_names_uniprotkb": "Gamma-interferon-inducible lysosomal thiol reductase; 1.8.4.-; Gamma-interferon-inducible protein IP-30; Legumaturain",
        "protein_names_refseq": "gamma-interferon-inducible lysosomal thiol reductase preproprotein; gamma-interferon-inducible lysosomal thiol reductase; gamma-interferon-inducible protein IP-30; interferon gamma-inducible protein 30 preproprotein; interferon, gamma-inducible protein 30; legumaturain",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10437);  (R-HSA-2132295);  (R-HSA-877300)",
        "pathway_count": 3,
        "publication_count": 193,
        "publication_id_list": "10.1101/2023.09.13.557529;10036229;10064083;10067896;10072072;10480952;10540230;10593899;10631941;10631952;10639150;10748235;10809954;10852914;10986460;11237011;11529500;11684289;11790530;11813165;11853874;11972023;12040185;12078484;12198549;12438563;12446674;12742663;12748383;12915721;1396683;14586410;14722222;14731593;1508672;15143187;15322115;15388922;1546328;15530433;15749704;15911768;16181339;16237089;16242130;16467876;16618111;16824007;17125875;17142755;17283181;18046453;18292509;18362138;18591661;1956401;19564404;20049711;20130243;20304997;20363976;21116285;21136679;2121367;21441454;2190094;22424782;23061660;23481700;2391366;24190977;24417533;24715725;25502872;25505266;25576301;25576336;25880248;26154972;26992070;27846572;27862975;28467828;28834231;28904123;29242379;29317506;29437277;29557506;29741879;30115740;30315122;30410026;30429286;31020640;31092671;31154438;31222486;3136170;31530632;31540894;31611695;31844290;31848261;31937595;31998317;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33043033;33123756;33141586;33239784;33298915;33537174;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34405274;34433824;34509645;35051231;35154160;35318648;35561310;35580925;35883685;36010968;36215666;36241641;37074911;37340703;37408388;37938771;37991414;38141017;38246175;7481823;7510216;7514165;7530745;7592972;7615558;7617032;7650016;7657660;7667286;7673114;7690989;7796299;8046351;8134367;8145819;8148318;8156998;8176225;8313912;8397411;8415765;8483949;8530158;8550631;8631301;8642258;8687433;8849454;8909537;8939989;8947036;9075930;9111318;9143706;9202021;9311912;9312039;9497313;9539769;9545226;9606180",
        "class_list": "",
        "function": "A Transcription Factor ZNF384, Regulated by LINC00265, Activates the Expression of IFI30 to Stimulate Malignant Progression in Glioma., [RefSeq, PubMed]; Comprehensive analysis of the role of interferon gamma-inducible protein 30 on immune infiltration and prognosis in clear cell renal cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; IDO1, FAT10, IFI6, and GILT Are Involved in the Antiretroviral Activity of gamma-Interferon and IDO1 Restricts Retrovirus Infection by Autophagy Enhancement. Publication Status: Online-Only, [RefSeq, PubMed]; Interferon-gamma inducible protein 30 promotes the epithelial-mesenchymal transition-like phenotype and chemoresistance by activating EGFR/AKT/GSK3beta/beta-catenin pathway in glioma., [RefSeq, PubMed]; Lysosomal thiol reductase that can reduce protein disulfide bonds. Facilitates the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing., [UniProtKB, UniProtKB]; Lysosomal thiol reductase that catalyzes protein disulfide bonds reduction (PubMed:10639150). Plays an important role in antigen processing and presentation, of namely both major histocompatibility complex (MHC) class I- and class II-restricted antigen by reducing the disulfide bonds of endocytosed proteins and facilitating their unfolding and optimal degradation (PubMed:10639150). Shares with thioredoxin a reduction mechanism in which the N-terminal cysteine thiol group in the CXXC active site motif initiates a nucleophilic attack on the substrate disulfide bond,resulting in the formation of a mixed disulfide-linked enzyme-substrate intermediate (Probable). Subsequent intramolecular attack by the second cysteine thiol group enables the release of the reduced substrate and oxidized enzyme (Probable). Lysosomal cysteine is a physiological reducing agent that is capable of reducing IFI30, so that it can catalyzes the next reaction (PubMed:10852914). Dithiothreitol, cysteine, and cysteinyl glycine, but not glutathione, are capable of regenerating active precursor and mature IFI30 in vitro (PubMed:10639150, PubMed:10852914)., [UniProtKB, PubMed, PubMed]; The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. [provided by RefSeq, Jul 2008]., [RefSeq]; [Knockdown of interferon-gamma inducible protein 30 (IFI30) inhibits the proliferation, invasion and migration of human glioma U251 cells by activating STAT1 and promotes their apoptosis]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 26,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q76MF9;Q8NEI4;Q8WU77;Q9UL08",
        "ec_number_list": "2.3.2.27;2.7.7.84;1.8.4.-;1.8.-.-;2.3.2.-;3.6.1.-;3.6.5.-;2.7.11.1;2.3.1.-;6.3.2.n3",
        "go_molecular_function": "GO:0016667 oxidoreductase activity, acting on a sulfur group of donors;GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome;GO:0043202 lysosomal lumen",
        "go_biological_process": "GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002376 immune system process",
        "synthesized_glycan_count": 0,
        "hit_score": 22.6,
        "record_id": "P13284-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZNI0-1",
        "uniprot_id": "GCNT7_HUMAN",
        "mass": 49319.0,
        "length": 430,
        "protein_name": "Probable beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7",
        "gene_name": "GCNT7",
        "organism": "Human",
        "refseq_name": "probable beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7 precursor",
        "refseq_ac": "NP_542182",
        "gene_names_uniprotkb": "GCNT7; C20orf105",
        "gene_names_refseq": "C20orf105; GCNT7; dJ1153D9.2; gcnt",
        "protein_names_uniprotkb": "Probable beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7; 2.4.1.-",
        "protein_names_refseq": "beta 1,6-N-acetylglucosaminyltransferase; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7; probable beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7 precursor; probable beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:140687);  (R-HSA-913709)",
        "pathway_count": 2,
        "publication_count": 24,
        "publication_id_list": "10330415;10430883;10753916;11042166;11283017;11304796;11821425;12855678;1329093;15486459;15560372;15620693;17113861;18537974;22183981;24643043;35051231;7655172;9295285;9394011;9417100;9435216;9915862;9988682",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Probable glycosyltransferase., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9HCV8",
        "ec_number_list": "2.4.1.102;2.4.1.150;2.4.1.148;2.4.1.-",
        "go_molecular_function": "GO:0008375 acetylglucosaminyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "Q6ZNI0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P11717-1",
        "uniprot_id": "MPRI_HUMAN",
        "mass": 274375.0,
        "length": 2491,
        "protein_name": "Cation-independent mannose-6-phosphate receptor",
        "gene_name": "IGF2R",
        "organism": "Human",
        "refseq_name": "cation-independent mannose-6-phosphate receptor precursor",
        "refseq_ac": "NP_000867",
        "gene_names_uniprotkb": "IGF2R; MPRI",
        "gene_names_refseq": "CD222; CI-M6PR; CIMPR; IGF2R; M6P-R; M6P/IGF2R; MPR 300; MPR1; MPR300; MPRI",
        "protein_names_uniprotkb": "Cation-independent mannose-6-phosphate receptor; 300 kDa mannose 6-phosphate receptor; CI Man-6-P receptor; CI-MPR; IGF-II receptor; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; M6P/IGF2 receptor; M6P/IGF2R; M6PR; MPR 300",
        "protein_names_refseq": "300 kDa mannose 6-phosphate receptor; CI Man-6-P receptor; IGF-II receptor; M6P/IGF2 receptor; cation-independent mannose-6-phosphate receptor precursor; cation-independent mannose-6-phosphate receptor; insulin-like growth factor II receptor",
        "tax_id": 9606,
        "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); colon carcinoma (Disease Ontology:DOID:1520); nephroblastoma (Disease Ontology:DOID:2154); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); breast carcinoma (Disease Ontology:DOID:3459); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); in situ carcinoma (Disease Ontology:DOID:8719); breast carcinoma in situ (Disease Ontology:DOID:8791); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744)",
        "pathway": " (hsa:3482);  (R-HSA-432722);  (R-HSA-6798695);  (R-HSA-6811440);  (R-HSA-8856825);  (R-HSA-8856828)",
        "pathway_count": 6,
        "publication_count": 464,
        "publication_id_list": "37639587;10.1101/2023.09.13.557529;10097102;10209123;10394364;10436022;10445031;10535736;10542231;10559856;10559861;10559924;10559959;10567358;10613896;10625686;10637310;10766823;10769163;10865125;10900005;10983987;10990452;11071885;11076969;11082044;11231140;11237011;11239472;11247302;11303027;11346801;11359012;11387475;11454741;11470803;11516654;11517213;11532990;11577110;11588219;11590181;11604418;11689439;11694590;11827983;11839770;11877457;11877461;11889126;11919637;11927540;11988742;11994746;12057195;12070132;12086608;12213833;12221107;12234931;12377769;12429842;12447393;12451172;12464600;12620188;12620189;12717448;12754519;12847086;12944396;12952949;12958364;1317852;1370435;14555962;14574404;14580338;14581451;14617351;14622578;14622579;14662753;14718928;14726597;15029241;15037235;15077113;15077114;15102850;15128430;15134832;15252009;15260957;15269279;15294879;15318165;15339664;1535555;15473838;15483056;15502812;15502813;15649145;15654769;15671180;15703209;15728179;15758030;15802264;15870108;15878329;15895077;15916959;16042553;16103228;16129887;16155256;16159959;16215232;16326391;16410077;16459302;16460808;16516836;16571679;16707488;16723738;16798879;16880396;16885419;16903783;16912714;16936697;17018281;17035995;17081983;17116749;17158794;17267500;17322306;17360967;17451557;17456551;17487921;17488291;17494869;17512409;17522231;17540576;17562788;17609109;17681954;17684057;17693683;17698061;17713526;17762867;17765681;17978091;18032517;18046459;18093523;18166656;18195106;18199683;18220336;18243103;18256213;18318008;18367545;18388313;18452278;1847920;18578522;18664496;18669648;18691976;18707149;18767875;18775314;18790740;18817523;18819912;18946081;18981233;19092055;19140243;19159218;19164740;19287005;19296720;19367720;19369195;19413330;19415658;19458185;19490898;19536138;19575674;19603039;19608861;19620288;19651622;19664994;19664995;1968060;19690332;19696796;19696798;19713939;19732400;19776351;19809571;19853559;20033059;20059951;20068231;20166139;20211604;20220067;20230923;20231386;20351096;20428113;20448150;20685960;20826345;20946875;21102408;2115402;21183348;21187331;21269460;21278753;21316588;21406692;21421921;21436057;21445324;21482805;21499258;21613550;21654843;21689688;21779028;21807881;21841790;21883765;21927000;21927001;21962517;21995445;22099461;22118466;22233676;22299025;22335553;22354037;22357968;22377707;22484487;22505844;2257624;22581368;22717455;22815487;22863004;22942912;23090970;23091056;23186163;23297414;23437303;23481700;23536704;23650620;23719902;23823722;23861397;23891661;24130457;24186068;24190977;24275569;24384571;24581490;24680432;24715725;24746795;24789820;24794632;24966051;25107275;25303366;25341920;25343031;25418920;25502872;25505266;25576301;25645385;25880248;25892735;25944712;26042225;26154972;26375851;26403691;26758079;26768311;26811146;26829388;26992070;27090790;27452731;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28467828;28514659;28649982;28832583;28834231;28871256;28904123;2890644;29242379;29314611;29317506;29331515;29391424;29393594;29437277;29493099;29508533;29557506;2957598;2963003;29632046;29632711;29671580;29741879;29769354;29786170;29789417;30315122;30410026;30429286;30459171;30573663;30626607;30779550;30833945;31020640;31092671;31154438;31217245;31222486;31611695;31844290;31848261;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32877646;32897882;32938616;32983136;33043033;33141586;33143702;33214551;33298915;33392160;33592498;33633747;33691108;33912179;33936100;33968037;33981976;34019948;34078123;34087483;34171305;3417785;34211107;34233296;34357683;34433824;34509645;34725712;34931806;34932366;35051231;35154160;35251023;35254053;35289036;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37074911;37340703;38253038;38612397;38665916;38701040;40596516;40914422;6146630;7493029;7569928;7822302;7877694;7909812;8111387;8220428;8221884;8267611;8318012;8374173;8440258;8524399;8552632;8553074;8606061;8620540;8636227;8670264;8670882;8692836;8837779;9050864;9092476;9100026;9169477;9177194;9230071;9303539;9427626;9428629;9590177;9635431;9722161;9723620;9736607;9812899;9892739",
        "class_list": "glycogene",
        "function": "Dysfunction in IGF2R Pathway and Associated Perturbations in Autophagy and WNT Processes in Beckwith-Wiedemann Syndrome Cell Lines. Publication Status: Online-Only, [RefSeq, PubMed]; Imprinting of IGF2R gene in human is polymorphic, with a minority of individuals showing exclusive expression from the maternal allele., [RefSeq, PubMed]; Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:18817523, PubMed:2963003). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The associations of IGF2, IGF2R and IGF2BP2 gene polymorphisms with gestational diabetes mellitus: A case-control study. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 20,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 21,
        "reported_o_glycosites_with_glycan": 10,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 24,
        "total_reported_o_glycosites": 10,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 24,
        "total_o_glycosites": 10,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 4,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2860,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 114,
        "disease_count": 12,
        "glyco_site_count": 35,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7Z7G9;Q96PT5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0051219 phosphoprotein binding;GO:0001965 G-protein alpha-subunit binding;GO:0005520 insulin-like growth factor binding",
        "go_cellular_component": "GO:0030118 clathrin coat;GO:0000139 Golgi membrane;GO:0005641 nuclear envelope lumen;GO:0005768 endosome;GO:0005769 early endosome",
        "go_biological_process": "GO:0001889 liver development;GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007283 spermatogenesis;GO:0043065 positive regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 61.3,
        "record_id": "P11717-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96A56-1",
        "uniprot_id": "T53I1_HUMAN",
        "mass": 27366.0,
        "length": 240,
        "protein_name": "Tumor protein p53-inducible nuclear protein 1",
        "gene_name": "TP53INP1",
        "organism": "Human",
        "refseq_name": "tumor protein p53-inducible nuclear protein 1 isoform b",
        "refseq_ac": "NP_001129205",
        "gene_names_uniprotkb": "TP53INP1; P53DINP1; SIP",
        "gene_names_refseq": "SIP; TP53DINP1; TP53INP1A; TP53INP1B; TP53INP1; Teap; p53DINP1",
        "protein_names_uniprotkb": "Tumor protein p53-inducible nuclear protein 1; Stress-induced protein; p53-dependent damage-inducible nuclear protein 1; p53DINP1",
        "protein_names_refseq": "p53-dependent damage-inducible nuclear protein 1; p53-inducible p53DINP1; stress-induced protein; tumor protein p53-inducible nuclear protein 1 isoform b",
        "tax_id": 9606,
        "disease": "abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221)",
        "pathway": " (hsa:94241);  (R-HSA-6803204);  (R-HSA-6804756)",
        "pathway_count": 3,
        "publication_count": 85,
        "publication_id_list": "10435622;10500146;10570149;10604467;10673500;10673501;10710310;10807576;10884347;11030628;11239457;11447225;11511362;11546806;11551930;11684014;11740489;11780126;12064478;12067065;12393879;12402042;12438758;12606722;12702766;12851404;12914926;14702041;14729977;15053879;15126337;15273740;15607964;15735003;15866171;16044147;16322561;16377624;17108107;17349958;17591690;18490454;18617898;19121998;19377469;19965871;20959462;21317932;22334068;22421968;22470510;22766503;23000554;23365256;23485397;23676219;23684607;23931759;24145406;24715725;24874608;25080938;25576301;26071602;28832583;29242379;30192525;31154438;31844290;31848261;32157095;32938616;33298915;33968037;34718338;35051231;35164998;35561310;35580925;35802258;35876212;36010968;38267567;7834749;9925639",
        "class_list": "",
        "function": "An approach for an enhanced anticancer activity of ferulic acid-loaded polymeric micelles via MicroRNA-221 mediated activation of TP53INP1 in caco-2 cell line. Publication Status: Online-Only, [RefSeq, PubMed]; Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC., [UniProtKB, PubMed, PubMed, PubMed]; Assignment of tumor protein p53 induced nuclear protein 1 (TP53INP1) gene to human chromosome band 8q22 by in situ hybridization., [RefSeq, PubMed]; Data show that induction of the stress-induced proteins (SIPs) SIP18 and SIP27, in human- and mouse-derived cell lines, is absent from cells with deleted, mutated or inactive p53, suggesting that regulation of SIP gene expression is dependent on p53., [RefSeq, PubMed]; LncRNA n339260 functions in hepatocellular carcinoma progression via regulation of miRNA30e-5p/TP53INP1 expression., [RefSeq, PubMed]; MiR-155 inhibits TP53INP1 expression leading to enhanced glycolysis of psoriatic mesenchymal stem cells., [RefSeq, PubMed]; MiR-8485 alleviates the injury of cardiomyocytes through TP53INP1., [RefSeq, PubMed]; MicroRNA-106a regulates autophagy-related cell death and EMT by targeting TP53INP1 in lung cancer with bone metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; TP53INP1s and HIPK2 could be partners in regulating p53 activity., [RefSeq, PubMed]; TP53INP1s are functionally associated with p73 to regulate cell cycle progression and apoptosis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCE5;Q969R9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0016209 antioxidant activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome",
        "go_biological_process": "GO:1904761 negative regulation of myofibroblast differentiation;GO:0000045 autophagosome assembly;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 8.6,
        "record_id": "Q96A56-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UJ14-1",
        "uniprot_id": "GGT7_HUMAN",
        "mass": 70467.0,
        "length": 662,
        "protein_name": "Glutathione hydrolase 7",
        "gene_name": "GGT7",
        "organism": "Human",
        "refseq_name": "glutathione hydrolase 7 isoform 1",
        "refseq_ac": "NP_821158",
        "gene_names_uniprotkb": "GGT7; GGTL3; GGTL5",
        "gene_names_refseq": "D20S101; GGT4; GGT7; GGTL3; GGTL5",
        "protein_names_uniprotkb": "Glutathione hydrolase 7; 2.3.2.2; 3.4.19.13; GGT 7; Gamma-glutamyltransferase 7; Gamma-glutamyltransferase-like 3; Gamma-glutamyltransferase-like 5; Gamma-glutamyltranspeptidase 7",
        "protein_names_refseq": "GGT 7; gamma-glutamyltransferase 4; gamma-glutamyltransferase-like 3; gamma-glutamyltransferase-like 5; gamma-glutamyltranspeptidase 7; gamma-glutamyltranspeptidase-like 3; glutathione hydrolase 7 isoform 1; glutathione hydrolase 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2686);  (R-HSA-174403);  (R-HSA-5423646);  (R-HSA-9753281)",
        "pathway_count": 4,
        "publication_count": 86,
        "publication_id_list": "10.1101/2023.09.13.557529;10369661;10741631;11237011;11409944;11714888;11904223;12144777;12270127;12473676;12727802;12933810;1504254;16385575;1643250;16696573;16970545;17627974;17924658;18232020;18357469;18416522;18515354;19109178;19413330;19463;19842618;20190787;21666065;21712391;22349737;22406294;23186163;23682772;24190977;2573352;25884624;25931127;26049587;26067475;26992070;28467828;29557506;29741879;31217245;32157095;32325220;32472168;32938616;32983136;33592498;3372534;3395122;33968037;34047475;34087483;34725712;35051231;35154160;35251023;35289036;35580925;35596634;35662282;36010968;37074911;38665916;3931076;6950087;70646;7469630;7646467;7764673;7766804;7826375;8439558;8703034;8812420;8813074;8975785;9024171;9080;9278457;9516961;9576847;9675072",
        "class_list": "",
        "function": "A genome-wide association study identifies novel association between genetic variants in GGT7 and LINC00944 and hypertension., [RefSeq, PubMed]; GGTL3 protein interacts with CT120, a plasma membrane-associated protein possibly involved in lung carcinogenesis., [RefSeq, PubMed]; Gamma-glutamyltransferase 7 suppresses gastric cancer by cooperating with RAB7 to induce mitophagy., [RefSeq, PubMed]; Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors., [UniProtKB, UniProtKB]; Our study demonstrates that GGT7 is a novel player in GBM growth and that GGT7 can play a critical role in tumorigenesis by regulating anti-oxidative damage. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008]., [RefSeq]; [The role of polymorphic variants rs11546155 and rs6119534 of the GGT7 gene and risk factors in the development of acute pancreatitis]., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 6,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 14,
        "disease_count": 0,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N899;Q8NF66;Q9BYP5;Q9BYP6",
        "ec_number_list": "2.3.2.2;3.4.19.13;3.4.19.14",
        "go_molecular_function": "GO:0036374 glutathione hydrolase activity;GO:0103068 leukotriene C4 gamma-glutamyl transferase activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0006751 glutathione catabolic process;GO:1901750 leukotriene D4 biosynthetic process;GO:1902883 negative regulation of response to oxidative stress",
        "synthesized_glycan_count": 0,
        "hit_score": 10.8,
        "record_id": "Q9UJ14-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IXW0-1",
        "uniprot_id": "LMTD2_HUMAN",
        "mass": 70379.0,
        "length": 634,
        "protein_name": "Lamin tail domain-containing protein 2",
        "gene_name": "LMNTD2",
        "organism": "Human",
        "refseq_name": "lamin tail domain-containing protein 2",
        "refseq_ac": "NP_775844",
        "gene_names_uniprotkb": "LMNTD2; C11orf35",
        "gene_names_refseq": "C11orf35; LMNTD2",
        "protein_names_uniprotkb": "Lamin tail domain-containing protein 2",
        "protein_names_refseq": "lamin tail domain-containing protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:256329)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11237011;28832583;29242379;32157095;35051231;38253038",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005638 lamin filament",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q8IXW0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NQC1-1",
        "uniprot_id": "JADE2_HUMAN",
        "mass": 87466.0,
        "length": 790,
        "protein_name": "E3 ubiquitin-protein ligase Jade-2",
        "gene_name": "JADE2",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase Jade-2 isoform 1",
        "refseq_ac": "NP_001276913",
        "gene_names_uniprotkb": "JADE2; KIAA0239; PHF15",
        "gene_names_refseq": "JADE-2; JADE2; PHF15",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Jade-2; 2.3.2.27; Jade family PHD finger protein 2; PHD finger protein 15",
        "protein_names_refseq": "E3 ubiquitin-protein ligase Jade-2 isoform 1; E3 ubiquitin-protein ligase Jade-2; PHD finger protein 15; jade family PHD finger protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23338);  (R-HSA-3214847)",
        "pathway_count": 2,
        "publication_count": 83,
        "publication_id_list": "10786633;10821277;11237011;14612400;15313887;16387653;18381289;18623064;18669648;19187765;19608861;20018852;22424782;22544926;23186163;23481700;24275569;24715725;25018020;25576301;26154972;26375851;26992070;27600516;27862975;27920218;28218747;28228285;28649982;28832583;28834231;28904123;29242379;29331515;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30410026;30429286;30524438;30779550;31154438;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33691108;33717175;33936100;33968037;33981976;34087483;34171305;34211107;34405274;34509645;34932366;35051231;35318648;35561310;35580925;36241641;37938771;9427644;9558366;9880483",
        "class_list": "",
        "function": "Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as an E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DQA3;Q6IE80;Q8TEK0;Q92513;Q96GQ6",
        "ec_number_list": "2.3.1.48;2.3.2.27",
        "go_molecular_function": "GO:0043997 histone H4K12 acetyltransferase activity;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0043995 histone H4K5 acetyltransferase activity;GO:0043996 histone H4K8 acetyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0000123 histone acetyltransferase complex",
        "go_biological_process": "GO:2000278 regulation of DNA biosynthetic process;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination;GO:0006275 regulation of DNA replication",
        "synthesized_glycan_count": 0,
        "hit_score": 8.4,
        "record_id": "Q9NQC1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6NX49-1",
        "uniprot_id": "ZN544_HUMAN",
        "mass": 81742.0,
        "length": 715,
        "protein_name": "Zinc finger protein 544",
        "gene_name": "ZNF544",
        "organism": "Human",
        "refseq_name": "zinc finger protein 544 isoform 1",
        "refseq_ac": "NP_001307696",
        "gene_names_uniprotkb": "ZNF544",
        "gene_names_refseq": "ZNF544",
        "protein_names_uniprotkb": "Zinc finger protein 544",
        "protein_names_refseq": "zinc finger protein 544 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:27300);  (R-HSA-212436)",
        "pathway_count": 2,
        "publication_count": 28,
        "publication_id_list": "10235266;10330177;11237011;11395415;14519192;15175151;15896744;16606702;16719718;2163759;23481700;24714562;24715725;25218447;27846572;29351928;29557506;30379171;31217245;31844290;35051231;35580925;36241641;36284347;8183939;8769649;9637681;9653119",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K6J1;Q9UEX4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q6NX49-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96DU7-1",
        "uniprot_id": "IP3KC_HUMAN",
        "mass": 75207.0,
        "length": 683,
        "protein_name": "Inositol-trisphosphate 3-kinase C",
        "gene_name": "ITPKC",
        "organism": "Human",
        "refseq_name": "inositol-trisphosphate 3-kinase C isoform 1",
        "refseq_ac": "NP_079470",
        "gene_names_uniprotkb": "ITPKC; IP3KC",
        "gene_names_refseq": "IP3-3KC; IP3KC; ITPKC",
        "protein_names_uniprotkb": "Inositol-trisphosphate 3-kinase C; 2.7.1.127; IP3 3-kinase C; IP3K C; Inositol 1,4,5-trisphosphate 3-kinase C; InsP 3-kinase C",
        "protein_names_refseq": "IP3 3-kinase C; IP3K C; InsP 3 kinase C; inositol 1,4,5-trisphosphate 3-kinase C; inositol-trisphosphate 3-kinase C isoform 1; insP 3-kinase C",
        "tax_id": 9606,
        "disease": "colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:80271);  (R-HSA-1855204)",
        "pathway_count": 2,
        "publication_count": 75,
        "publication_id_list": "10593988;10866302;11022047;11022048;11042108;11085927;11118617;11237011;11909533;12223481;12747803;1333955;15037625;15140260;15316017;15474001;15579586;15702972;15790568;16107206;1644792;1718960;18084290;19179337;20045869;23186163;24275569;2550068;25576301;25645385;2841328;28832583;28834231;28904123;29242379;29508533;29557506;30355649;30779550;30833945;31154438;31844290;32157095;32357974;32387766;32938616;33392160;33470690;33537174;33912179;33968037;33981976;34171305;34185709;34509645;34932366;34952936;35051231;35353363;35580925;36010968;37404818;37938771;7721860;7761412;7890667;8407970;8454637;8530101;8662638;8723348;8769125;9360711;9430698;9593664",
        "class_list": "",
        "function": "A statistically significant association was not found between the ITPKC gene single-nucleotide polymorphism rs28493229 and Kawasaki disease or coronary artery lesions in Taiwanese children. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Association of ITPKC gene polymorphisms rs28493229 and rs2290692 in North Indian children with Kawasaki disease., [RefSeq, PubMed]; Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis (PubMed:11085927, PubMed:12747803). Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; ITPKC acts as a negative regulator of T-cell activation through the Ca2+/NFAT signaling pathway, and the C allele may contribute to immune hyper-reactivity in Kawasaki disease., [RefSeq, PubMed]; ITPKC polymorphism (rs7251246 T > C), coronary artery aneurysms, and thrombosis in patients with Kawasaki disease in a Southern Han Chinese population. Publication Status: Online-Only, [RefSeq, PubMed]; Immune-related genes STIM1, ITPKC and PELI1 polymorphisms are associated with risk of colorectal cancer., [RefSeq, PubMed]; Inositol-Triphosphate 3-Kinase C and DNA Methylation Involvement in NLRP3 Inflammasome Activation in Kawasaki Disease., [RefSeq, PubMed]; Our findings suggest that ITPKC is a susceptibility gene for bone mineral density (BMD), and rs2607420 may play an important role in the regulation of this gene Publication Status: Online-Only, [RefSeq, PubMed]; Results highlight the potential role of the three isoforms of InsP3 3-kinase as direct InsP3 metabolizing enzymes and direct regulators of Ca2+ responses to extracellular signals, [RefSeq, PubMed]; This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.[provided by RefSeq, Sep 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UE25;Q9Y475",
        "ec_number_list": "2.7.1.127;2.7.-.-",
        "go_molecular_function": "GO:0000828 inositol hexakisphosphate kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity;GO:0000166 nucleotide binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0071277 cellular response to calcium ion;GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:0032958 inositol phosphate biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.6,
        "record_id": "Q96DU7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BYH8-1",
        "uniprot_id": "IKBZ_HUMAN",
        "mass": 78061.0,
        "length": 718,
        "protein_name": "NF-kappa-B inhibitor zeta",
        "gene_name": "NFKBIZ",
        "organism": "Human",
        "refseq_name": "NF-kappa-B inhibitor zeta isoform b",
        "refseq_ac": "NP_001005474",
        "gene_names_uniprotkb": "NFKBIZ; IKBZ; INAP; MAIL",
        "gene_names_refseq": "I-kappa-B-zeta; IKBZ; INAP; IkappaB-zeta; MAIL; NFKBIZ; ikB-zeta; ikappaBzeta",
        "protein_names_uniprotkb": "NF-kappa-B inhibitor zeta; I-kappa-B-zeta; IL-1 inducible nuclear ankyrin-repeat protein; INAP; IkB-zeta; IkappaBzeta; MAIL; Molecule possessing ankyrin repeats induced by lipopolysaccharide",
        "protein_names_refseq": "IL-1 inducible nuclear ankyrin-repeat protein; NF-kappa-B inhibitor zeta isoform b; NF-kappa-B inhibitor zeta; molecule possessing ankyrin repeats induced by lipopolysaccharide; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta",
        "tax_id": 9606,
        "disease": "Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); atopic dermatitis (Disease Ontology:DOID:3310)",
        "pathway": " (hsa:64332)",
        "pathway_count": 1,
        "publication_count": 37,
        "publication_id_list": "11237011;12565889;16513645;16622025;24715725;25892735;27600516;27846572;28832583;29242379;29393594;29557506;29769354;31217245;31844290;32157095;32387766;32488085;32938616;32983136;33123756;33592498;33691108;33717175;33968037;34171305;34932366;35051231;35318648;35580925;36284347;36581221;37725983;38581570;38960718;39273036;39322062",
        "class_list": "",
        "function": "Assessing the association between common functional Nuclear Factor Kappa-b gene polymorphisms (NFKB1, NFKBIZ, NFKBIA) and Alzheimer s disease., [RefSeq, PubMed]; IkappaBzeta is an essential mediator of immunity to oropharyngeal candidiasis., [RefSeq, PubMed]; Involved in regulation of NF-kappa-B transcription factor complexes (PubMed:16513645, PubMed:16622025). Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation (PubMed:16513645). Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer (PubMed:16513645). Also seems to activate NF-kappa-B-mediated transcription (PubMed:16622025). In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters (PubMed:16622025). Promotes transcription of LCN2 and DEFB4 (PubMed:16622025). Is recruited to IL-6 promoters and activates IL-6 but decreases TNF production in response to LPS (By similarity). Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Also seems to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR)., [UniProtKB, UniProtKB]; NFKBIZ regulates NFkappaB signaling pathway to mediate tumorigenesis and metastasis of hepatocellular carcinoma by direct interaction with TRIM16. Publication Status: Online-Only, [RefSeq, PubMed]; Structural and biochemical analyses of the nuclear IkappaBzeta protein in complex with the NF-kappaB p50 homodimer. Publication Status: Online-Only, [RefSeq, PubMed]; The Nuclear NF-kappaB Regulator IkappaBzeta: Updates on Its Molecular Functions and Pathophysiological Roles. Review article Publication Status: Online-Only, [RefSeq, PubMed]; These results indicate the existence of another signal essential for I kappa B-zeta induction, which is specifically mediated by the Toll/interleukin-1 receptor (TIR) domain-mediated signaling pathway., [RefSeq, PubMed]; This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KNR2;D3DN54;Q8IUL4;Q8NAZ8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0070974 POU domain binding;GO:0003712 transcription coregulator activity;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0045063 T-helper 1 cell differentiation;GO:0032980 keratinocyte activation;GO:2000321 positive regulation of T-helper 17 cell differentiation;GO:0006338 chromatin remodeling;GO:0042117 monocyte activation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.8,
        "record_id": "Q9BYH8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86YD3-1",
        "uniprot_id": "TMM25_HUMAN",
        "mass": 39285.0,
        "length": 366,
        "protein_name": "Transmembrane protein 25",
        "gene_name": "TMEM25",
        "organism": "Human",
        "refseq_name": "transmembrane protein 25 isoform 6 precursor",
        "refseq_ac": "NP_001305684",
        "gene_names_uniprotkb": "TMEM25; PRO6030",
        "gene_names_refseq": "TMEM25",
        "protein_names_uniprotkb": "Transmembrane protein 25",
        "protein_names_refseq": "0610039J01Rik; transmembrane protein 25 isoform 6 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84866)",
        "pathway_count": 1,
        "publication_count": 22,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;12975309;15340161;16303743;19776672;23090970;23324576;24190977;25645385;28904123;29242379;31424425;31844290;33298915;34357683;35494241;36010968;37074911;37846797;38177906;38189809",
        "class_list": "",
        "function": "Human-biased TMEM25 expression promotes expansion of neural progenitor cells to alter cortical structure in the developing brain., [RefSeq, PubMed]; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability., [UniProtKB, PubMed]; Multidimensional comprehensive and integrated analysis of the potential function of TMEM25 in renal clear cell carcinoma with low expression status., [RefSeq, PubMed]; TMEM25 hypermethylation might play a significant role in altering expression of this gene in colorectal cancer., [RefSeq, PubMed]; TMEM25 is a Par3-binding protein that attenuates claudin assembly during tight junction development., [RefSeq, PubMed]; TMEM25 may be a useful tumor marker for favorable prognosis in breast cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 9194,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K8J4;B0YJA6;B0YJA7;B0YJA9;G5E9U4;Q6UW89;Q86UA7;Q8NBL5;Q96KA6;Q96MW9",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005770 late endosome;GO:0016020 membrane",
        "go_biological_process": "GO:0031647 regulation of protein stability;GO:0090394 negative regulation of excitatory postsynaptic potential",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q86YD3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P18065-1",
        "uniprot_id": "IBP2_HUMAN",
        "mass": 34814.0,
        "length": 325,
        "protein_name": "Insulin-like growth factor-binding protein 2",
        "gene_name": "IGFBP2",
        "organism": "Human",
        "refseq_name": "insulin-like growth factor-binding protein 2 isoform b",
        "refseq_ac": "NP_001300919",
        "gene_names_uniprotkb": "IGFBP2; BP2; IBP2",
        "gene_names_refseq": "IBP2; IGF-BP53; IGFBP2",
        "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 2; IBP-2; IGF-binding protein 2; IGFBP-2",
        "protein_names_refseq": "IGF-binding protein 2; insulin-like growth factor binding protein 2, 36kDa; insulin-like growth factor-binding protein 2 isoform b",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); hypothyroidism (Disease Ontology:DOID:1459); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:3485);  (R-HSA-381426)",
        "pathway_count": 2,
        "publication_count": 94,
        "publication_id_list": "10.1074/mcp.M114.046862;10026136;10077652;10218588;10512690;10614670;10681634;10810289;10898936;10912521;10951195;10990447;11158056;11237011;11250653;11264294;11316783;11522292;11606061;11739083;11751371;11788658;12241545;12379487;12466191;12810533;12904166;1370451;1376411;1383255;15126567;15308688;15469690;15485880;15525596;15642270;16569642;1697583;17020769;17047378;1710112;1712312;17249697;1726837;17312271;17985932;18563800;19081843;22869525;2476804;2479552;25502872;25813380;26076738;26091039;29314611;29557506;30459171;31154438;31844290;32350084;33592498;34035374;34171305;35051231;35251023;36010968;38490505;38506034;38665916;38729152;38796567;38918360;39007351;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7683646;7689487;8781553;8817670;8894645;8964575;9497324;9709957;9733769;9786878;9922210",
        "class_list": "",
        "function": "A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion., [RefSeq, PubMed]; Age-Related Increases in IGFBP2 Increase Melanoma Cell Invasion and Lipid Synthesis., [RefSeq, PubMed]; Exosomal IGFBP2 derived from highly metastatic promotes hepatocellular carcinoma metastasis by inducing epithelial mesenchymal transition., [RefSeq, PubMed]; IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:18563800, PubMed:38796567). Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation (PubMed:22869525). Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif (PubMed:16569642). Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells (PubMed:26076738). Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury (PubMed:38796567)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]., [RefSeq]; The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 5,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14619;Q9UCL3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding;GO:0141069 receptor ligand inhibitor activity;GO:0005520 insulin-like growth factor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0070062 extracellular exosome;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0007584 response to nutrient;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0051384 response to glucocorticoid;GO:0007565 female pregnancy;GO:0009612 response to mechanical stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 10.1,
        "record_id": "P18065-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96P16-1",
        "uniprot_id": "RPR1A_HUMAN",
        "mass": 35720.0,
        "length": 312,
        "protein_name": "Regulation of nuclear pre-mRNA domain-containing protein 1A",
        "gene_name": "RPRD1A",
        "organism": "Human",
        "refseq_name": "regulation of nuclear pre-mRNA domain-containing protein 1A isoform 3",
        "refseq_ac": "NP_001290342",
        "gene_names_uniprotkb": "RPRD1A; P15RS",
        "gene_names_refseq": "HsT3101; P15RS; RPRD1A",
        "protein_names_uniprotkb": "Regulation of nuclear pre-mRNA domain-containing protein 1A; Cyclin-dependent kinase inhibitor 2B-related protein; p15INK4B-related protein",
        "protein_names_refseq": "CDKN2B-related protein; Cyclin-dependent kinase inhibitor 2B-related protein (p15INK4B-related protein); cyclin-dependent kinase 2B-inhibitor-related protein; p15INK4B-related protein; regulation of nuclear pre-mRNA domain-containing protein 1A isoform 3; regulation of nuclear pre-mRNA domain-containing protein 1A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55197);  (R-HSA-6807505)",
        "pathway_count": 2,
        "publication_count": 107,
        "publication_id_list": "10022900;11237011;11856838;12414730;12470661;12574128;14701755;1535687;16239144;16308568;16901896;16959974;1739980;18079403;1829677;19667075;20068231;20457598;20739273;2125285;22137580;22231121;22252320;22441827;22580456;23166507;23186163;23301498;23481700;23932780;24097444;24270878;24275569;24399136;24714562;24715725;24997600;25576301;25645385;25675981;26375851;26728094;26992070;27600516;27846572;28228285;28832583;28834231;28904123;29242379;2944599;29493099;29508533;29557506;29632711;29786170;30315122;30410026;30779550;30833945;31154438;31217245;31222486;31530632;31844290;31848261;32157095;32161166;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33633747;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34509645;34921137;34932366;35051231;35254053;35580925;36010968;36241641;40136647;40596516;40914422;7715707;8253082;8339931;8628262;8668525;9009278;9153304;9188510;9407024;9705341;9832505",
        "class_list": "",
        "function": "Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Molecular cloning and characterization of P15RS, a novel P15(INK4b) related gene involved in G1/S progression, [RefSeq, PubMed]; P15RS inhibits Wnt signaling by interrupting beta-catenin.TCF4 complex formation and that Wnt signaling initiates downstream gene expression by removing p15RS from promoters., [RefSeq, PubMed]; RPRD1A stabilizes NRF2 and aggravates HCC progression through competing with p62 for TRIM21 binding. Publication Status: Online-Only, [RefSeq, PubMed]; The p15RS expression specifically downregulates the expression of cathepsin B and MMP-9 at RNA levels, which are known to promote cell invasion through degrading extracellular matrix proteins., [RefSeq, PubMed]; This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Dec 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KA42;B2RBA3;Q7Z5G8;Q96FY9;Q9NVL4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0000993 RNA polymerase II complex binding;GO:0099122 RNA polymerase II C-terminal domain binding;GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity",
        "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0001111 RNA polymerase II promoter clearance;GO:0031124 mRNA 3'-end processing",
        "synthesized_glycan_count": 0,
        "hit_score": 11.3,
        "record_id": "Q96P16-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q17R60-1",
        "uniprot_id": "IMPG1_HUMAN",
        "mass": 89387.0,
        "length": 797,
        "protein_name": "Interphotoreceptor matrix proteoglycan 1",
        "gene_name": "IMPG1",
        "organism": "Human",
        "refseq_name": "interphotoreceptor matrix proteoglycan 1 isoform 2 precursor",
        "refseq_ac": "NP_001269297",
        "gene_names_uniprotkb": "IMPG1; IPM150; SPACR",
        "gene_names_refseq": "GP147; IMPG1; IPM150; RP91; SPACR; VMD4",
        "protein_names_uniprotkb": "Interphotoreceptor matrix proteoglycan 1; IPM-150; Interphotoreceptor matrix proteoglycan of 150 kDa; Sialoprotein associated with cones and rods",
        "protein_names_refseq": "interphotoreceptor matrix proteoglycan 1 isoform 2 precursor; interphotoreceptor matrix proteoglycan of 150 kDa; sialoprotein associated with cones and rods",
        "tax_id": 9606,
        "disease": "vitelliform macular dystrophy (Disease Ontology:DOID:0050661); retinitis pigmentosa 91 (Disease Ontology:DOID:0061106)",
        "pathway": " (hsa:3617)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "10601738;11237011;14691150;18510355;23993198;25085631;25645385;28644393;29557506;29777959;30688845;32817297;34087483;36284347;9691169;9719680;9813076",
        "class_list": "",
        "function": "Chondroitin sulfate-, heparin- and hyaluronan-binding protein (By similarity). May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix (PubMed:9813076)., [UniProtKB, PubMed, UniProtKB]; Chondroitin sulfate-, heparin- and hyaluronan-binding protein. May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix., [UniProtKB, UniProtKB]; Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix., [RefSeq, PubMed]; IMPG1 and IMPG2 are new causal genes of vitelliform dystrophy, involved in 8% of our families., [RefSeq, PubMed]; Pathogenic variants in IMPG1 cause autosomal dominant and autosomal recessive retinitis pigmentosa., [RefSeq, PubMed]; The gene product of IMPG1 (designated IPM 150) is a member of a group of neuronal proteoglycans and/ or glycoproteins suspected to be essential in retinal adhesion and photoreceptor cell survival., [RefSeq, PubMed]; This gene encodes a protein that is a major component of the retinal interphotoreceptor matrix. The encoded protein is a proteoglycan that is thought to play a role in maintaining viability of photoreceptor cells and in adhesion of the neural retina to the retinal pigment epithelium. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]., [RefSeq]",
        "predicted_glycosites": 12,
        "predicted_n_glycosites": 8,
        "predicted_o_glycosites": 4,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 60,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NNZ6;O43686;O95094;Q68D53;Q9BWZ1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008201 heparin binding;GO:0035374 chondroitin sulfate binding;GO:0005201 extracellular matrix structural constituent;GO:0005540 hyaluronic acid binding",
        "go_cellular_component": "GO:0033165 interphotoreceptor matrix;GO:0031012 extracellular matrix;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment;GO:0140150 gel phase of interstitial matrix",
        "go_biological_process": "GO:0007601 visual perception",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q17R60-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P17020-1",
        "uniprot_id": "ZNF16_HUMAN",
        "mass": 76472.0,
        "length": 682,
        "protein_name": "Zinc finger protein 16",
        "gene_name": "ZNF16",
        "organism": "Human",
        "refseq_name": "zinc finger protein 16 isoform 1",
        "refseq_ac": "NP_001025147",
        "gene_names_uniprotkb": "ZNF16; HZF1; KOX9",
        "gene_names_refseq": "HZF1; KOX9; ZNF16",
        "protein_names_uniprotkb": "Zinc finger protein 16; Zinc finger protein KOX9",
        "protein_names_refseq": "zinc finger protein 16 isoform 1; zinc finger protein KOX9; zinc finger protein Kruppel type 9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7564)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "11237011;16628192;18077418;19608861;19763908;21468593;21874239;2288909;24180487;25418920;25892735;26154972;28063628;28832583;28904123;31217245;31844290;32157095;32387766;32432340;32460791;33717175;35051231",
        "class_list": "",
        "function": "Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Also plays a role as an inhibitor of cell apoptosis., [UniProtKB, PubMed, PubMed, PubMed]; Exome sequencing identifies new somatic alterations and mutation patterns of tongue squamous cell carcinoma in a Chinese population., [RefSeq, PubMed]; Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Study demonstrate that ZNF16 plays an important role in erythropoiesis and megakaryocytopoiesis via its regulation of the c-Kit/c-Raf/MEK/ERK/c-Jun/HEY1/GATA1 cascade, [RefSeq, PubMed]; The protein encoded by this gene contains multiple tandem zinc finger motifs. The encoded protein is involved in the differentiation of erythroid and megakaryocytic cells. This gene is located in a cluster of related genes on chromosome 8 encoding zinc finger proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KXM4;D3DWP2;Q45SH7;Q96FG0;Q9NRA4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus",
        "go_biological_process": "GO:0072707 cellular response to sodium dodecyl sulfate;GO:1901989 positive regulation of cell cycle phase transition;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "P17020-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P46063-1",
        "uniprot_id": "RECQ1_HUMAN",
        "mass": 73457.0,
        "length": 649,
        "protein_name": "ATP-dependent DNA helicase Q1",
        "gene_name": "RECQL",
        "organism": "Human",
        "refseq_name": "ATP-dependent DNA helicase Q1",
        "refseq_ac": "NP_002898",
        "gene_names_uniprotkb": "RECQL; RECQ1; RECQL1",
        "gene_names_refseq": "RECON; RECQL1; RECQL; RecQ1",
        "protein_names_uniprotkb": "ATP-dependent DNA helicase Q1; 5.6.2.4; DNA 3'-5' helicase Q1; DNA helicase, RecQ-like type 1; DNA-dependent ATPase Q1; RecQ protein-like 1; RecQ1",
        "protein_names_refseq": "ATP-dependent DNA helicase Q1; DNA 3'-5' helicase Q1; DNA helicase, RecQ-like type 1; DNA-dependent ATPase Q1; RecQ helicase-like; RecQ protein-like (DNA helicase Q1-like); recQ protein-like 1",
        "tax_id": 9606,
        "disease": "lung cancer (Disease Ontology:DOID:1324); pancreatic cancer (Disease Ontology:DOID:1793); hepatocellular carcinoma (Disease Ontology:DOID:684); RECON progeroid syndrome (MONDO:MONDO:0957266)",
        "pathway": " (hsa:5965)",
        "pathway_count": 1,
        "publication_count": 92,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;15886194;18426915;19151156;19608861;20068231;22645359;23186163;23301498;24366607;24715725;25576301;25645385;25831490;25892735;26154972;26811146;26992070;27600516;27655845;27862975;28218747;28228285;28510447;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30379171;30410026;30429286;30524438;30833945;31154438;31217245;31530632;31844290;31848261;31998317;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33214551;33298915;33592498;33633747;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34229054;34357683;34509645;34725712;34751402;35025765;35051231;35231585;35561310;35580925;36010968;36215666;36284347;37938771;38665916;38874681;40596516;7527136;7961977;8056767",
        "class_list": "",
        "function": "DNA helicase that plays a role in DNA damage repair and genome stability (PubMed:15886194, PubMed:35025765, PubMed:7527136, PubMed:7961977, PubMed:8056767). Exhibits a Mg(2+)- and ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:19151156, PubMed:35025765, PubMed:7527136, PubMed:8056767). Full-length protein unwinds forked DNA substrates, resolves Holliday junctions, and has DNA strand annealing activity (PubMed:19151156, PubMed:25831490). Plays a role in restoring regressed replication forks (PubMed:35025765). Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions (PubMed:35025765). Does not unwind G-quadruplex DNA (PubMed:18426915). May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens (PubMed:15886194, PubMed:7961977)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Genome-wide investigations on regulatory functions of RECQ1 helicase., [RefSeq, PubMed]; RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1., [RefSeq, PubMed]; RecQ helicase expression in patients with telomeropathies. Publication Status: Online-Only, [RefSeq, PubMed]; Residues at the interface between zinc binding and winged helix domains of human RECQ1 play a significant role in DNA strand annealing activity., [RefSeq, PubMed]; The protein encoded by this gene is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. The encoded protein is involved in the processing of Holliday junctions, the suppression of sister chromatid exchanges, telomere maintenance, and is required for genotoxic stress resistance. Defects in this gene have been associated with several types of cancer. [provided by RefSeq, Jan 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 31,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 4,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K6G2",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0003678 DNA helicase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005694 chromosome",
        "go_biological_process": "GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0000724 double-strand break repair via homologous recombination;GO:0031297 replication fork processing",
        "synthesized_glycan_count": 0,
        "hit_score": 9.7,
        "record_id": "P46063-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y303-1",
        "uniprot_id": "NAGA_HUMAN",
        "mass": 43748.0,
        "length": 409,
        "protein_name": "N-acetylglucosamine-6-phosphate deacetylase",
        "gene_name": "AMDHD2",
        "organism": "Human",
        "refseq_name": "N-acetylglucosamine-6-phosphate deacetylase isoform 2",
        "refseq_ac": "NP_001139287",
        "gene_names_uniprotkb": "AMDHD2; CGI-14",
        "gene_names_refseq": "AMDHD2; CGI-14",
        "protein_names_uniprotkb": "N-acetylglucosamine-6-phosphate deacetylase; 3.5.1.25; Amidohydrolase domain-containing protein 2; GlcNAc 6-P deacetylase",
        "protein_names_refseq": "N-acetylglucosamine-6-phosphate deacetylase isoform 2; amidohydrolase domain-containing protein 2; glcNAc 6-P deacetylase; putative N-acetylglucosamine-6-phosphate deacetylase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51005);  (R-HSA-446210)",
        "pathway_count": 2,
        "publication_count": 36,
        "publication_id_list": "10198162;10824116;11237011;11707391;11726282;12174217;1460020;16959974;17010375;18675810;21073341;21310273;22692205;25576301;26154972;27920218;28063628;28832583;28904123;29393594;29557506;29632046;30524438;31844290;32157095;32350084;32387766;32488085;32502341;32938616;32983136;33123756;34561969;35580925;37938771;9990133",
        "class_list": "glycogene",
        "function": "Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded., [UniProtKB, PubMed, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 509,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DL77;Q8WV54",
        "ec_number_list": "3.5.1.25",
        "go_molecular_function": "GO:0008448 N-acetylglucosamine-6-phosphate deacetylase activity;GO:0046872 metal ion binding;GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol",
        "go_biological_process": "GO:0006046 N-acetylglucosamine catabolic process;GO:0006048 UDP-N-acetylglucosamine biosynthetic process;GO:0019262 N-acetylneuraminate catabolic process;GO:0106279 negative regulation of UDP-N-acetylglucosamine biosynthetic process;GO:0006044 N-acetylglucosamine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "Q9Y303-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5QGT7-1",
        "uniprot_id": "RTP2_HUMAN",
        "mass": 26068.0,
        "length": 225,
        "protein_name": "Receptor-transporting protein 2",
        "gene_name": "RTP2",
        "organism": "Human",
        "refseq_name": "receptor-transporting protein 2",
        "refseq_ac": "NP_001004312",
        "gene_names_uniprotkb": "RTP2; Z3CXXC2",
        "gene_names_refseq": "RTP2; Z3CXXC2",
        "protein_names_uniprotkb": "Receptor-transporting protein 2; 3CxxC-type zinc finger protein 2",
        "protein_names_refseq": "3CxxC-type zinc finger protein 2; receptor (chemosensory) transporter protein 2; receptor-transporting protein 2; zinc finger, 3CxxC-type 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:344892);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 7,
        "publication_id_list": "15550249;16720576;24800820;27515280;28586385;31974307;32066986",
        "class_list": "",
        "function": "Further cell-surface and permeabilized immunocytochemical studies revealed that odorant receptors (ORs) and the co-expressed RTP1S proteins were retained in the Golgi when co-transfected with RTP2, indicating that RTP1S and RTP2 could play different roles in the OR trafficking process. Publication Status: Online-Only, [RefSeq, PubMed]; Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6NVH4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031849 olfactory receptor binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface",
        "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0051205 protein insertion into membrane;GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q5QGT7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6P087-1",
        "uniprot_id": "RUSD3_HUMAN",
        "mass": 38461.0,
        "length": 351,
        "protein_name": "Mitochondrial mRNA pseudouridine synthase RPUSD3",
        "gene_name": "RPUSD3",
        "organism": "Human",
        "refseq_name": "mitochondrial mRNA pseudouridine synthase RPUSD3 isoform 2",
        "refseq_ac": "NP_001136019",
        "gene_names_uniprotkb": "RPUSD3",
        "gene_names_refseq": "RPUSD3",
        "protein_names_uniprotkb": "Mitochondrial mRNA pseudouridine synthase RPUSD3; 5.4.99.-; RNA pseudouridylate synthase domain-containing protein 3",
        "protein_names_refseq": "RNA pseudouridylate synthase domain containing 3; RNA pseudouridylate synthase domain-containing protein 3; mitochondrial mRNA pseudouridine synthase RPUSD3 isoform 2; mitochondrial mRNA pseudouridine synthase RPUSD3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:285367);  (R-HSA-6793080);  (R-HSA-9937008)",
        "pathway_count": 3,
        "publication_count": 51,
        "publication_id_list": "11237011;11809803;12496758;15110318;15769737;18083837;19356719;19417006;21292163;21531335;22341444;22544926;22949673;23022348;23186163;23303773;23481700;23804760;24036117;25008111;25009282;25074936;25418920;26464487;26811146;26929215;27667664;27846572;27920218;27974379;28082677;28228285;28832583;28904123;29107537;29242379;29393594;29632046;29786170;30524438;31217245;31477916;31844290;32157095;32387766;32488085;32938616;33141586;33968037;34171305;35051231",
        "class_list": "",
        "function": "Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post-transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA (PubMed:27974379). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis (PubMed:27667664)., [UniProtKB, PubMed, PubMed]; This gene encodes a protein that functions in the assembly of the mitochondrial ribosome by adding a pseudouridine group to 16S rRNA. Loss of this gene results in causes defects in mitochondrial protein production. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DS39;Q6P6A9;Q8N1B2;Q8NAV3",
        "ec_number_list": "5.4.99.25;5.4.99.-;5.4.99.42;5.4.99.28;5.4.99.12",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0009982 pseudouridine synthase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0035770 ribonucleoprotein granule",
        "go_biological_process": "GO:0000455 enzyme-directed rRNA pseudouridine synthesis;GO:0006397 mRNA processing;GO:0016556 mRNA modification;GO:1990481 mRNA pseudouridine synthesis;GO:0070131 positive regulation of mitochondrial translation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.2,
        "record_id": "Q6P087-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13572-1",
        "uniprot_id": "ITPK1_HUMAN",
        "mass": 45621.0,
        "length": 414,
        "protein_name": "Inositol-tetrakisphosphate 1-kinase",
        "gene_name": "ITPK1",
        "organism": "Human",
        "refseq_name": "inositol-tetrakisphosphate 1-kinase isoform a",
        "refseq_ac": "NP_001136065",
        "gene_names_uniprotkb": "ITPK1",
        "gene_names_refseq": "ITPK1; ITRPK1",
        "protein_names_uniprotkb": "Inositol-tetrakisphosphate 1-kinase; 2.7.1.134; 2.7.1.159; Inositol 1,3,4-trisphosphate 5/6-kinase; Inositol-triphosphate 5/6-kinase; Ins(1,3,4)P(3) 5/6-kinase",
        "protein_names_refseq": "inositol 1,3,4-trisphosphate 5/6-kinase; inositol-tetrakisphosphate 1-kinase isoform a; ins(1,3,4)P(3) 5/6-kinase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3705);  (R-HSA-1855167);  (R-HSA-1855204);  (R-HSA-983231)",
        "pathway_count": 4,
        "publication_count": 152,
        "publication_id_list": "10419486;10585413;10593988;10777568;10827188;10866302;11022047;11022048;11042108;11062261;11118617;11237011;11242053;11502751;11533064;11744692;11751636;11895428;11909533;11950885;12032298;12084730;12105228;12121577;12134158;12223481;12324474;12427746;12747803;12925536;1333955;15020713;15037625;15140260;15247287;15316017;15474001;15579586;15702972;15710388;15762844;15790568;15837423;16054028;16107206;1630448;1644792;17027967;1718960;17196961;17412958;17616525;17690096;17702752;17705785;18355727;18981179;19179337;19293402;20530532;20627800;218813;22119861;22308441;23186163;23481700;24715725;2550068;25576301;25645385;25892735;26375851;26845023;26992070;27600516;27846572;27862975;27920218;28218747;28228285;2841328;28514659;28649982;28832583;28834231;28904123;29242379;29331515;29437277;29493099;29557506;29632711;29769354;29786170;29883610;30315122;30410026;30429286;30833945;31092671;31154438;31754032;31844290;31848261;31937595;31998317;32157095;32161166;32357974;32488085;32897882;32938616;32983136;33123756;33141586;33298915;33592498;33912179;33936100;33968037;34087483;3409321;34171305;34357683;34932366;35051231;35580925;36010968;36284347;36323916;37938771;40914422;7721860;7761412;7890667;8407970;8454637;8530101;8662638;8723348;8769125;8816476;9065479;9230307;9326583;9331217;9360711;9422515;9430698;9593664;9822604;9927674",
        "class_list": "",
        "function": "Genetic Effects of ITPK1 Polymorphisms on the Risk of Neural Tube Defects: a Population-Based Study., [RefSeq, PubMed]; ITPK1 role in the lipid-independent synthesis of inositol phosphates., [RefSeq, PubMed]; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3 (PubMed:11042108, PubMed:8662638). Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5 (PubMed:11042108). This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway (PubMed:11042108, PubMed:8662638). Also acts as an inositol polyphosphate phosphatase that dephosphorylates Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4 (PubMed:11909533, PubMed:17616525). May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium (PubMed:11909533). Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (PubMed:11909533, PubMed:12925536, PubMed:17616525). Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:17616525)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes an enzyme that belongs to the inositol 1,3,4-trisphosphate 5/6-kinase family. This enzyme regulates the synthesis of inositol tetraphosphate, and downstream products, inositol pentakisphosphate and inositol hexakisphosphate. Inositol metabolism plays a role in the development of the neural tube. Disruptions in this gene are thought to be associated with neural tube defects. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 23,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BTL6;Q9H2E7",
        "ec_number_list": "3.1.3.86;3.1.3.56;3.1.3.36;2.7.1.134;2.7.1.159",
        "go_molecular_function": "GO:0047325 inositol-3,4,5,6-tetrakisphosphate 1-kinase activity;GO:0052725 inositol-1,3,4-trisphosphate 6-kinase activity;GO:0052726 inositol-1,3,4-trisphosphate 5-kinase activity;GO:0052835 inositol-3,4,6-trisphosphate 1-kinase activity;GO:0000287 magnesium ion binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007596 blood coagulation;GO:0070266 necroptotic process;GO:0032957 inositol trisphosphate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 15.5,
        "record_id": "Q13572-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z3D6-1",
        "uniprot_id": "GLUCM_HUMAN",
        "mass": 66437.0,
        "length": 616,
        "protein_name": "D-glutamate cyclase, mitochondrial",
        "gene_name": "DGLUCY",
        "organism": "Human",
        "refseq_name": "D-glutamate cyclase, mitochondrial isoform a precursor",
        "refseq_ac": "NP_001095836",
        "gene_names_uniprotkb": "DGLUCY; C14orf159; PRO5000",
        "gene_names_refseq": "C14orf159; DGLUCY",
        "protein_names_uniprotkb": "D-glutamate cyclase, mitochondrial; 4.2.1.48",
        "protein_names_refseq": "D-glutamate cyclase, mitochondrial isoform a precursor; D-glutamate cyclase, mitochondrial; UPF0317 protein C14orf159, mitochondrial",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80017)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "11237011;12975309;18767875;20877624;29351928;29557506;30524438;32387766;33968037;34211107;34357683;35051231",
        "class_list": "",
        "function": "D-glutamate cyclase that converts D-glutamate to 5-oxo-D-proline., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KUI7;Q86SW3;Q86SX8;Q86SX9;Q86T08;Q86TV5;Q96GW5;Q9H7G0;Q9H8Y9;Q9H9W6",
        "ec_number_list": "4.2.1.48",
        "go_molecular_function": "GO:0047820 D-glutamate cyclase activity;GO:0016829 lyase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol",
        "go_biological_process": "GO:0006536 glutamate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q7Z3D6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q64LD2-1",
        "uniprot_id": "WDR25_HUMAN",
        "mass": 60161.0,
        "length": 544,
        "protein_name": "WD repeat-containing protein 25",
        "gene_name": "WDR25",
        "organism": "Human",
        "refseq_name": "WD repeat-containing protein 25 isoform a",
        "refseq_ac": "NP_001154948",
        "gene_names_uniprotkb": "WDR25; C14orf67",
        "gene_names_refseq": "C14orf67; WDR25",
        "protein_names_uniprotkb": "WD repeat-containing protein 25",
        "protein_names_refseq": "WD repeat-containing protein 25 isoform a; WD repeat-containing protein 25; epididymis secretory sperm binding protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79446)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "11237011;15587985;23481700;24715725;26992070;27920218;28411811;29242379;29393594;29557506;29632046;29786170;30379171;30429286;30484775;31217245;31844290;32357974;32387766;32938616;33912179;33968037;34171305;35051231",
        "class_list": "",
        "function": "This gene encodes a protein containing 7 WD repeats. WD repeats are approximately 30 to 40-amino acid domains containing several conserved residues, typically having a Tryptophan-Aspartic acid dipeptide (WD) at the C-terminal end. WD domains are involved in protein-protein interactions in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K7E5;Q6NVV6;Q86TQ4;Q9BTK5",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q64LD2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6XQN6-1",
        "uniprot_id": "PNCB_HUMAN",
        "mass": 57578.0,
        "length": 538,
        "protein_name": "Nicotinate phosphoribosyltransferase",
        "gene_name": "NAPRT",
        "organism": "Human",
        "refseq_name": "nicotinate phosphoribosyltransferase isoform 2",
        "refseq_ac": "NP_001273758",
        "gene_names_uniprotkb": "NAPRT; FHIP; NAPRT1",
        "gene_names_refseq": "NAPRT1; NAPRT; PP3856",
        "protein_names_uniprotkb": "Nicotinate phosphoribosyltransferase; 6.3.4.21; FHA-HIT-interacting protein; NAPRTase; Nicotinate phosphoribosyltransferase domain-containing protein 1",
        "protein_names_refseq": "FHA-HIT-interacting protein; NAPRTase; nicotinate phosphoribosyltransferase domain containing 1; nicotinate phosphoribosyltransferase domain-containing protein 1; nicotinate phosphoribosyltransferase isoform 2; nicotinic acid phosphoribosyltransferase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:93100);  (R-HSA-196807);  (R-HSA-6798695)",
        "pathway_count": 3,
        "publication_count": 104,
        "publication_id_list": "10331643;10613898;11237011;11248244;11594753;11788603;11866528;11991719;12359228;12547821;12574164;12790796;13563527;14516279;14966140;15090606;15137942;15381699;15674325;16118205;1637327;16690024;16964243;17081983;17402747;17604275;17641676;17868694;17914902;18411268;18669648;18767875;19531469;19664995;20068231;20230923;20388704;2129526;21406692;21492230;21504897;21699903;21742010;21933152;21994945;22701565;22822066;23212377;23230272;23481700;23650620;24275569;24715725;24717514;24847004;25531177;25576301;25645385;26042198;26154972;26992070;27862975;28063628;28218747;28832583;29242379;29557506;29786170;30524438;30573663;30779550;31268507;31439867;31511522;31844290;32157095;32350084;32387766;32488085;32502341;32906142;32938616;32983136;33043033;33087354;33141586;33968037;33981976;34171305;34509645;34946971;35051231;35580925;36215666;36241641;36432602;4349867;8182091;8289818;8527488;8575745;8692836;8809081;9473669",
        "class_list": "",
        "function": "Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study., [RefSeq, PubMed]; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198). Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; NA elevates cellular NAD levels through NAPRT function and, thus, protects the cells against stress, partly due to lack of feedback inhibition of NAPRT but not NamPRT by NAD, [RefSeq, PubMed]; NAPRT Expression Regulation Mechanisms: Novel Functions Predicted by a Bioinformatics Approach. Publication Status: Online-Only, [RefSeq, PubMed]; NAPRT expression was varied in lymphomas with 30-50% low expression except for Hodgkin's lymphoma where 85% displayed low expression, [RefSeq, PubMed]; NAPRT, but Not NAMPT, Provides Additional Support for NAD Synthesis in Esophageal Precancerous Lesions. Publication Status: Online-Only, [RefSeq, PubMed]; Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008]., [RefSeq]; Study demonstrated that PPM1D mutant astrocytes and patient-derived PPM1D mutant diffuse intrinsic pontine glioma lines are particularly sensitive to treatment with NAMPT inhibitors. Mutant PPM1D-induced NAMPT inhibitor sensitivity is driven by hypermethylation of CpG islands throughout the genome and the epigenetic silencing of NAPRT, a key gene involved in NAD biosynthesis. Publication Status: Online-Only, [RefSeq, PubMed]; These data identify NAPRT as a endogenous ligand for TLR4 and a mediator of inflammation. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7BFI3;Q6PJL1;Q6XQN4;Q6XQN5;Q8N5E8;Q9BRG0",
        "ec_number_list": "4.6.1.19;3.2.1.24;1.6.2.2;3.2.1.51;3.5.3.1;1.11.2.2;3.2.1.-;3.2.1.22;3.4.21.4;3.2.1.52;3.2.1.31;3.4.21.37;3.4.21.20;4.6.1.18;3.4.16.5;3.4.16.-;2.4.1.1;3.1.27.-;3.1.6.8;3.1.6.14;3.1.6.12;3.2.1.23;1.1.1.205;3.5.1.26;3.4.21.76;2.7.11.24;1.11.1.27;3.1.1.4;2.3.1.23;3.1.6.4;2.7.10.2;3.6.1.-;2.3.3.8;3.4.14.1;3.6.4.6;3.2.1.17;2.7.11.13;6.3.4.21;1.8.4.-;5.3.4.1;3.4.19.9;1.6.5.5;3.1.3.16;5.3.99.3;3.5.4.4;3.4.14.2;3.5.3.15",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0016740 transferase activity;GO:0004516 nicotinate phosphoribosyltransferase activity;GO:0016757 glycosyltransferase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0035578 azurophil granule lumen",
        "go_biological_process": "GO:0006979 response to oxidative stress;GO:0034355 NAD+ biosynthetic process via the salvage pathway;GO:0009435 NAD+ biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 10.5,
        "record_id": "Q6XQN6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q00978-1",
        "uniprot_id": "IRF9_HUMAN",
        "mass": 43696.0,
        "length": 393,
        "protein_name": "Interferon regulatory factor 9",
        "gene_name": "IRF9",
        "organism": "Human",
        "refseq_name": "interferon regulatory factor 9 isoform 2",
        "refseq_ac": "NP_006075",
        "gene_names_uniprotkb": "IRF9; ISGF3G",
        "gene_names_refseq": "IRF-9; IRF9; ISGF3G; ISGF3; p48",
        "protein_names_uniprotkb": "Interferon regulatory factor 9; IFN-alpha-responsive transcription factor subunit; IRF-9; ISGF-3 gamma; ISGF3 p48 subunit; Interferon-stimulated gene factor 3 gamma; Transcriptional regulator ISGF3 subunit gamma",
        "protein_names_refseq": "IFN-alpha-responsive transcription factor subunit; ISGF-3 gamma; ISGF3 p48 subunit; interferon regulatory factor 9 isoform 2; interferon-stimulated gene factor 3 gamma; interferon-stimulated transcription factor 3, gamma (48kD); interferon-stimulated transcription factor 3, gamma 48kDa; transcriptional regulator ISGF3 subunit gamma",
        "tax_id": 9606,
        "disease": "immunodeficiency 65 (Disease Ontology:DOID:0111978); familial hyperlipidemia (Disease Ontology:DOID:1168); hepatitis C (Disease Ontology:DOID:1883); acute pancreatitis (Disease Ontology:DOID:2913)",
        "pathway": " (hsa:10379);  (R-HSA-877300);  (R-HSA-909733)",
        "pathway_count": 3,
        "publication_count": 172,
        "publication_id_list": "10067896;10395669;10542297;10702714;10982844;10986460;11092454;11237011;11337497;11377645;11404376;11585831;11846981;11972023;12029096;12040185;12438563;12446674;12766484;12842042;12915721;1396683;14586410;14722222;14769151;15047845;1508672;15143187;15312780;15322115;15388922;15449939;15530433;15778442;16009940;16171819;16237089;1630447;16467876;16987978;17125875;17251292;1730654;17351669;17969444;18035202;18362138;18575461;18591661;20049711;20130243;20304997;20363976;20643137;2211721;23061660;23121362;23481700;24417533;24714562;25371710;25505266;25548167;25576301;26154972;26375851;26728094;26992070;27058226;27397612;27600516;27846572;27862975;27920218;28228285;28832583;28860189;28904123;29242379;29331515;29393594;29493099;29508533;29557506;29786170;29789417;30143481;30315122;30485383;30524438;30826365;30833945;31154438;31844290;31848261;31937595;31998317;32032529;32113509;32157095;32357974;32488085;32502341;32511913;32574262;32661006;32699158;32758689;32862111;32938616;32983136;33117408;33123756;33141586;33189161;33193462;33239784;33298915;33396578;33592498;33691108;33717175;33968037;34087483;34171305;34211107;34561969;34932366;35051231;35318648;35494241;35580925;36010968;37144865;38139463;38514903;38788537;6162102;6548414;688397;7510216;7514165;7526154;7530745;7537377;7540766;7615558;7617032;7657660;7673114;7690989;7796299;8156998;8176225;8197134;8232552;8483949;8530158;8550631;8605876;8621447;8631301;8702790;9096384;9111318;9121453;9143706;9242679;9334213;9660177;9847332;9861020",
        "class_list": "",
        "function": "Elevated unphosphorylated STAT1 and IRF9 in T and B cells of primary sjogren's syndrome: Novel biomarkers for disease activity and subsets., [RefSeq, PubMed]; ISGF3 and STAT2/IRF9 Control Basal and IFN-Induced Transcription through Genome-Wide Binding of Phosphorylated and Unphosphorylated Complexes to Common ISRE-Containing ISGs. Publication Status: Online-Only, [RefSeq, PubMed]; The lack of either IRF9, or STAT2, has surprisingly little effect on human natural killer cell development and function., [RefSeq, PubMed]; This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Mutations in this gene result in Immunodeficiency 65. [provided by RefSeq, Jul 2020]., [RefSeq]; Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Twist1-IRF9 Interaction Is Necessary for IFN-Stimulated Gene Anti-Zika Viral Infection., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DS61",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0000976 transcription cis-regulatory region binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007166 cell surface receptor signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051607 defense response to virus;GO:0006366 transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 17.3,
        "record_id": "Q00978-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A8MWY0-1",
        "uniprot_id": "ELAP2_HUMAN",
        "mass": 113842.0,
        "length": 1029,
        "protein_name": "Endosome/lysosome-associated apoptosis and autophagy regulator family member 2",
        "gene_name": "ELAPOR2",
        "organism": "Human",
        "refseq_name": "endosome/lysosome-associated apoptosis and autophagy regulator family member 2 isoform 1 precursor",
        "refseq_ac": "NP_001136221",
        "gene_names_uniprotkb": "ELAPOR2; EIG121L; KIAA1324L",
        "gene_names_refseq": "EIG121L; ELAPOR2; KIAA1324L",
        "protein_names_uniprotkb": "Endosome/lysosome-associated apoptosis and autophagy regulator family member 2; Estrogen-induced gene 121-like protein; hEIG121L",
        "protein_names_refseq": "EIG121-like; KIAA1324 like; UPF0577 protein KIAA1324-like; endosome/lysosome-associated apoptosis and autophagy regulator family member 2 isoform 1 precursor; estrogen-induced gene 121-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:222223)",
        "pathway_count": 1,
        "publication_count": 34,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;17475571;23186163;23481700;24190977;25576301;25892735;27869121;27920218;28228285;28904123;29242379;29557506;29769354;30315122;31844290;32157095;32350084;32357974;32502341;32938616;33141586;33298915;33912179;34087483;34357683;35051231;35154160;35251023;35494241;36010968;36241641;37938771",
        "class_list": "",
        "function": "Functions as a regulator of the BMP signaling pathway and may be involved in epidermal differentiation., [UniProtKB, UniProtKB]; Similar to EIG121L gene, expressed in various organs of Xenopus during development., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 54,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D1C9;B4DJV3;Q17RI6;Q96DP2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0070700 BMP receptor binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0030513 positive regulation of BMP signaling pathway;GO:0045684 positive regulation of epidermis development;GO:0051961 negative regulation of nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "A8MWY0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P13378-1",
        "uniprot_id": "HXD8_HUMAN",
        "mass": 31911.0,
        "length": 290,
        "protein_name": "Homeobox protein Hox-D8",
        "gene_name": "HOXD8",
        "organism": "Human",
        "refseq_name": "homeobox protein Hox-D8 isoform 2",
        "refseq_ac": "NP_001186675",
        "gene_names_uniprotkb": "HOXD8; HOX4E",
        "gene_names_refseq": "HOX4E; HOX4; HOX5.4; HOXD8",
        "protein_names_uniprotkb": "Homeobox protein Hox-D8; Homeobox protein Hox-4E; Homeobox protein Hox-5.4",
        "protein_names_refseq": "Hox-4.5; homeo box 4E; homeo box D8; homeobox protein 5.4; homeobox protein Hox-4E; homeobox protein Hox-5.4; homeobox protein Hox-D8 isoform 2; homeobox protein Hox-D8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3234)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "11237011;11857506;2568311;25892735;28218747;30315122;30379171;31154438;31844290;32357974;32387766;32488085;33298915;33311496;33592498;33912179;34454307;35051231;35177798;35426617;36215666",
        "class_list": "",
        "function": "CircTMEM59 Serves as miR-410-3p Sponge to Inhibit the Proliferation and Metastasis of Colorectal Cancer by Regulating HOXD8., [RefSeq, PubMed]; HOXD8 hypermethylation as a fully sensitive and specific biomarker for biliary tract cancer detectable in tissue and bile samples., [RefSeq, PubMed]; HOXD8 inhibits the proliferation and migration of triple-negative breast cancer cells and induces apoptosis in them through regulation of AKT/mTOR pathway., [RefSeq, PubMed]; LINC01106 post-transcriptionally regulates ELK3 and HOXD8 to promote bladder cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F8WBG7;Q5BL00;Q8IXZ1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008595 anterior/posterior axis specification, embryo",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "P13378-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6PI26-1",
        "uniprot_id": "SHQ1_HUMAN",
        "mass": 65125.0,
        "length": 577,
        "protein_name": "Protein SHQ1 homolog",
        "gene_name": "SHQ1",
        "organism": "Human",
        "refseq_name": "protein SHQ1 homolog",
        "refseq_ac": "NP_060600",
        "gene_names_uniprotkb": "SHQ1",
        "gene_names_refseq": "DYT35; GRIM-1; NEDDS; SHQ1; Shq1p",
        "protein_names_uniprotkb": "Protein SHQ1 homolog",
        "protein_names_refseq": "SHQ1 homolog; gene associated with retinoid and interferon-induced mortality 1; protein SHQ1 homolog",
        "tax_id": 9606,
        "disease": "dystonia 35, childhood-onset (Disease Ontology:DOID:0060955); neurodevelopmental disorder with dystonia and seizures (MONDO:MONDO:0859258)",
        "pathway": " (hsa:55164);  (R-HSA-171319)",
        "pathway_count": 2,
        "publication_count": 93,
        "publication_id_list": "11237011;12699629;15060173;15189140;16339074;16522649;17172855;17395830;18358808;18523010;19179534;19383767;19734544;20404094;20524933;21931644;22579284;23103865;23481700;23657261;23783831;24715725;25081541;25128433;25271372;25418920;25553844;25576301;25620558;25645385;25892735;26154972;26728094;26992070;27600516;27846572;27862975;28228285;28446606;28514659;28832583;28834231;28904123;29178645;29242379;29493099;29508533;29557506;29695869;29769354;29786170;29789417;30315122;30429286;30524438;30779550;31217245;31723267;31844290;32157095;32357974;32387766;32488085;32502341;32522979;32897882;32938616;32983136;33123756;33141586;33298915;33392160;33592498;33717175;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34509645;34542157;34932366;35051231;35318648;35580925;36010968;36215666;36241641;36284347;36847845;37938771",
        "class_list": "",
        "function": "Biallelic SHQ1 variants in early infantile hypotonia and paroxysmal dystonia as the leading manifestation., [RefSeq, PubMed]; Compound heterozygous variants in SHQ1 are associated with a spectrum of neurological features, including early-onset dystonia., [RefSeq, PubMed]; Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA., [UniProtKB, PubMed, PubMed]; SHQ1 assists in the assembly of H/ACA-box ribonucleoproteins that function in the processing of ribosomal RNAs, modification of spliceosomal small nuclear RNAs, and stabilization of telomerase (see MIM 602322) (Grozdanov et al., 2009 [PubMed 19383767]).[supplied by OMIM, Dec 2010]., [RefSeq]; SHQ1 is an ER stress response gene that facilitates chemotherapeutics-induced apoptosis via sensitizing ER-stress response. Publication Status: Online-Only, [RefSeq, PubMed]; Study suggests that GRIM-1 (SHQ1) might act as a co-tumor suppressor in the prostate, [RefSeq, PubMed]; The expression of GRIM-1 and GRP78 was negatively correlated in human non-small cell lung cancer (NSCLC) tissues, and the down-regulation of GRP78 by GRIM-1 provides a possible mechanism for their interaction., [RefSeq, PubMed]; These results provide insight into the Shq1/dyskerin (Cbf5) interaction that plays a critical role in H/ACA RNP biogenesis and assembly in eukaryotes, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DL05;Q6MZJ4;Q7Z748;Q9H7E5;Q9NVS8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0051082 unfolded protein binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0090671 telomerase RNA localization to Cajal body;GO:0022618 protein-RNA complex assembly;GO:0000493 box H/ACA snoRNP assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 9.4,
        "record_id": "Q6PI26-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H3H5-1",
        "uniprot_id": "GPT_HUMAN",
        "mass": 46090.0,
        "length": 408,
        "protein_name": "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase",
        "gene_name": "DPAGT1",
        "organism": "Human",
        "refseq_name": "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase",
        "refseq_ac": "NP_001373",
        "gene_names_uniprotkb": "DPAGT1; DPAGT2",
        "gene_names_refseq": "ALG7; CDG-Ij; CDG1J; CMS13; CMSTA2; D11S366; DGPT; DPAGT1; DPAGT2; DPAGT; G1PT; GPT; UAGT; UGAT",
        "protein_names_uniprotkb": "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; 2.7.8.15; G1PT; GPT; GlcNAc-1-P transferase; N-acetylglucosamine-1-phosphate transferase",
        "protein_names_refseq": "GlcNAc-1-P transferase 1; N-acetylglucosamine-1-phosphate transferase; UDP-GlcNAc:dolichyl-phosphate N-acetylglucosaminephosphotransferase; UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 1; UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase); dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P tra; dolichyl-phosphate alpha-N-acetylglucosaminyltransferase",
        "tax_id": 9606,
        "disease": "congenital disorder of glycosylation Ij (Disease Ontology:DOID:0080562); congenital myasthenic syndrome 13 (Disease Ontology:DOID:0110676)",
        "pathway": " (hsa:1798);  (R-HSA-446193);  (R-HSA-4549356)",
        "pathway_count": 3,
        "publication_count": 94,
        "publication_id_list": "10.1101/2023.09.13.557529;10359825;10704531;11237011;11278778;11807558;11983712;12030331;12200473;12684507;12872255;14709599;14973778;14973782;15148656;15235028;15710750;15840742;15945070;16007612;16100110;16859551;16878994;16959974;18313027;18597486;19282279;22304930;22492991;22742743;23249953;23481700;24366607;24714562;25418920;25576301;25645385;25880248;25892735;26154972;27397612;27600516;27920218;28218747;28228285;28510447;28514659;28832583;28855257;28904123;29242379;29437277;29459785;29493099;29508533;29557506;30315122;30388443;30779550;31154438;31530632;31844290;31848261;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32901097;32938616;32983136;33141586;33298915;33392160;33912179;33968037;34087483;34185709;34211107;34357683;34509645;34561969;34932366;35051231;35580925;36241641;36284347;36581221;37005892;37421173;9451016;9597543",
        "class_list": "glycogene;glycosyltransferase",
        "function": "DPAGT1-CDG: Recurrent fetal death., [RefSeq, PubMed]; NFAT5 promotes oral squamous cell carcinoma progression in a hyperosmotic environment., [RefSeq, PubMed]; Novel DPAGT1 Gene Mutation in Two Twins with Congenital Myasthenic Syndrome and a Review of the Literature. Review article, [RefSeq, PubMed]; The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. [provided by RefSeq, Jul 2008]., [RefSeq]; UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transferring GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 24,
        "reported_glycation": 0,
        "reported_snv": 477,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O15216;Q86WV9;Q9BWE6",
        "ec_number_list": "2.7.8.15",
        "go_molecular_function": "GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0016757 glycosyltransferase activity;GO:0003975 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0043231 intracellular membrane-bounded organelle;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation",
        "synthesized_glycan_count": 15150,
        "hit_score": 9.9,
        "record_id": "Q9H3H5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TED1-1",
        "uniprot_id": "GPX8_HUMAN",
        "mass": 23881.0,
        "length": 209,
        "protein_name": "Protein peroxidase GPX8",
        "gene_name": "GPX8",
        "organism": "Human",
        "refseq_name": "probable glutathione peroxidase 8 isoform b",
        "refseq_ac": "NP_001293126",
        "gene_names_uniprotkb": "GPX8; PRO1785",
        "gene_names_refseq": "EPLA847; GPX8; GPx-8; GSHPx-8; UNQ847",
        "protein_names_uniprotkb": "Protein peroxidase GPX8; 5.3.4.1; GPx-8; GSHPx-8",
        "protein_names_refseq": "probable glutathione peroxidase 8 isoform b; probable glutathione peroxidase 8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:493869);  (R-HSA-3299685)",
        "pathway_count": 2,
        "publication_count": 112,
        "publication_id_list": "10029572;10514471;10521424;10656833;10833429;10919671;10982;11018045;11139407;11237011;11507097;11518528;11886899;11912930;12446202;12829378;12975309;15044467;15046979;15064408;15280035;15317809;15596429;15927447;16401067;16615992;1668270;16750198;16880213;17275676;17519234;1763037;17707404;18358825;18703498;18936159;19219623;19542232;1999334;20070187;20367259;20690882;2071038;21215271;21385867;21393238;21967640;22493009;22869735;22910329;23152058;23164639;23454490;23455484;23929719;24566470;25047527;25576301;27846572;28129698;29242379;29393594;29557506;29786170;29789417;30833945;31844290;31848261;32157095;32161166;32719007;32897882;32938616;33592498;33968037;34171305;3457020;35051231;35251023;35289036;35318648;3532102;35580925;36052280;3619451;36215666;36241641;36284347;3693360;37170591;37795080;38515109;38607517;38665916;40596516;5389100;60;6286671;6961438;7021796;7172448;7487923;807573;8379940;8428933;8452552;8663465;9295278;9369223;9639555;9726962;9923614",
        "class_list": "",
        "function": "Acts as an endoplasmic reticulum (ER) thiol peroxidase that maintains ER redox homeostasis and protects the cytosol from ER-derived H(2)O(2)(PubMed:24566470, PubMed:32719007). Functions in a redox relay with ERO1A, using ERO1A-generated H(2)O(2) to drive PDI oxidation, linking peroxide detoxification to productive disulfide formation (PubMed:21215271). Modulates endoplasmic reticulum Ca(2+) levels mainly through SERCA pump activity and partially by influencing passive Ca(2+) leakage (PubMed:28129698)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration., [RefSeq, PubMed]; GPX8 as a Novel Prognostic Factor and Potential Therapeutic Target in Primary Glioma. Publication Status: Online-Only, [RefSeq, PubMed]; GPX8 deficiency-induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells., [RefSeq, PubMed]; GPX8 regulates pan-apoptosis in gliomas to promote microglial migration and mediate immunotherapy responses. Publication Status: Online-Only, [RefSeq, PubMed]; GPX8[+] cancer-associated fibroblast, as a cancer-promoting factor in lung adenocarcinoma, is related to the immunosuppressive microenvironment. Publication Status: Online-Only, [RefSeq, PubMed]; GPx8 labeled as secreted glutathione peroxidase, is actually endoplasmic reticulum-resident protein disulfide isomerase peroxidase, [RefSeq, PubMed]; Quantitative proteomics identifies the membrane-associated peroxidase GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "1.11.1.9;1.11.1.27;1.16.3.1;1.16.3.4;1.11.1.12;5.3.4.1;1.8.3.2",
        "go_molecular_function": "GO:0004601 peroxidase activity;GO:0004602 glutathione peroxidase activity",
        "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0016020 membrane",
        "go_biological_process": "GO:0034599 cellular response to oxidative stress",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "Q8TED1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q75QN2-1",
        "uniprot_id": "INT8_HUMAN",
        "mass": 113088.0,
        "length": 995,
        "protein_name": "Integrator complex subunit 8",
        "gene_name": "INTS8",
        "organism": "Human",
        "refseq_name": "integrator complex subunit 8",
        "refseq_ac": "NP_060334",
        "gene_names_uniprotkb": "INTS8; C8orf52",
        "gene_names_refseq": "C8orf52; INT8; INTS8; NEDCHS",
        "protein_names_uniprotkb": "Integrator complex subunit 8; Int8; Protein kaonashi-1",
        "protein_names_refseq": "integrator complex subunit 8; protein kaonashi-1",
        "tax_id": 9606,
        "disease": "neurodevelopmental disorder with cerebellar hypoplasia and spasticity (MONDO:MONDO:0032818)",
        "pathway": " (hsa:55656);  (R-HSA-6807505)",
        "pathway_count": 2,
        "publication_count": 121,
        "publication_id_list": "10022900;11237011;11856838;12414730;12574128;14701755;1535687;16239144;16308568;16901896;17081983;1739980;18079403;1829677;18452278;19667075;20068231;20457598;2125285;22137580;22231121;22252320;22441827;23166507;23481700;23932780;24097444;24270878;24366607;24714562;24997600;25576301;25645385;25675981;26154972;26728094;26992070;27397612;27600516;27846572;27862975;27920218;28218747;28228285;28542170;28832583;28834231;28904123;29242379;29331515;29393594;29437277;2944599;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30410026;30429286;30484775;30524438;30779550;30833945;31154438;31530632;31844290;31848261;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32966759;32983136;33141586;33243860;33298915;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34004147;34087483;34171305;34405274;34509645;34762484;34932366;35051231;35561310;35580925;36215666;36241641;36869814;37080207;37938771;38570683;38823386;39032490;7715707;8253082;8339931;8628262;8668525;9009278;9153304;9188510;9407024;9705341;9832505",
        "class_list": "",
        "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:28542170, PubMed:33243860, PubMed:34004147, PubMed:37080207, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:34004147, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS8 is required for the recruitment of protein phosphatase 2A (PP2A) to transcription pause-release checkpoint (PubMed:32966759, PubMed:33243860, PubMed:34004147, PubMed:37080207)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Mutations INTS8 cause a severe neurodevelopmental syndrome.  INTS8 mutations lead in vitro to instability of the complex and impaired function. Erratum:[PLoS Genet. 2017 Aug 1;13(8):e1006923. doi: 10.1371/journal.pgen.1006923. PMID: 28763441] Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RN92;Q5RKZ3;Q6P1R5;Q7Z314;Q9NVS6;Q9NWY7",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0032039 integrator complex;GO:0160232 INTAC complex",
        "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0016180 snRNA processing;GO:0071168 protein localization to chromatin;GO:0034472 snRNA 3'-end processing;GO:0160240 RNA polymerase II transcription initiation surveillance",
        "synthesized_glycan_count": 0,
        "hit_score": 12.2,
        "record_id": "Q75QN2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6PI98-1",
        "uniprot_id": "IN80C_HUMAN",
        "mass": 20643.0,
        "length": 192,
        "protein_name": "INO80 complex subunit C",
        "gene_name": "INO80C",
        "organism": "Human",
        "refseq_name": "INO80 complex subunit C isoform 1",
        "refseq_ac": "NP_001092287",
        "gene_names_uniprotkb": "INO80C; C18orf37",
        "gene_names_refseq": "C18orf37; IES6; INO80C; hIes6",
        "protein_names_uniprotkb": "INO80 complex subunit C; IES6 homolog; hIes6",
        "protein_names_refseq": "IES6 homolog; INO80 complex subunit C isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:125476);  (R-HSA-5689603);  (R-HSA-5696394)",
        "pathway_count": 3,
        "publication_count": 85,
        "publication_id_list": "10391953;11237011;11279143;12732143;12815074;12944386;14742321;15811629;15882621;15944288;15960975;15964821;16223728;16230350;16473935;16678110;16906146;17139257;17882165;18497827;18922472;19109893;19188440;19609301;19664995;19815555;20068231;20112406;20436459;20805357;20855601;21135142;21303910;21388382;22118460;23045548;23319653;24714562;2530630;25469497;25576301;25880248;26154972;26811146;26992070;27846572;27920218;28063628;28228285;28832583;28860189;28904123;28954733;29242379;29331515;29393594;29508533;29557506;29632046;29632711;29786170;30315122;30833945;31154438;31530632;31844290;31848261;32157095;32161166;32357974;32387766;32502341;32983136;33592498;33968037;34185709;34932366;35051231;35561310;35580925;36241641;36284347;8168482;9528852;9790970",
        "class_list": "",
        "function": "C18orf37, similar in sequence to yeast Ies6p.  A subunit of the Ino80 chromatin remodeling complex, which has roles in transcription and DNA repair., [RefSeq, PubMed]; Data indicate metabolic enzymes NAD kinase and ketohexokinase as candidate metabolic gene targets, and the chromatin remodeling protein INO80C as a tumor suppressor in KRAS(MUT) colorectal tumor xenograft., [RefSeq, PubMed]; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DUI4;E9PCS7;Q86WR1;Q8N994",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0031011 Ino80 complex;GO:0001650 fibrillar center;GO:0071339 MLL1 complex",
        "go_biological_process": "GO:0060382 regulation of DNA strand elongation;GO:0033044 regulation of chromosome organization;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling",
        "synthesized_glycan_count": 0,
        "hit_score": 8.6,
        "record_id": "Q6PI98-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6UWN8-1",
        "uniprot_id": "ISK6_HUMAN",
        "mass": 8585.0,
        "length": 80,
        "protein_name": "Serine protease inhibitor Kazal-type 6",
        "gene_name": "SPINK6",
        "organism": "Human",
        "refseq_name": "serine protease inhibitor Kazal-type 6 precursor",
        "refseq_ac": "NP_001182219",
        "gene_names_uniprotkb": "SPINK6; PRO1782",
        "gene_names_refseq": "BUSI2; SPINK6; UNQ844",
        "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 6; Kallikrein inhibitor",
        "protein_names_refseq": "acrosin inhibitor; kallikrein inhibitor; protease inhibitor H; serine protease inhibitor Kazal-type 6 precursor; serine protease inhibitor Kazal-type 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:404203);  (R-HSA-6809371)",
        "pathway_count": 2,
        "publication_count": 45,
        "publication_id_list": "10066784;10196183;10231017;10411887;10588656;10771479;11237011;11350120;11380615;11590230;12902340;12975309;15033990;15337775;15340161;15797384;15803139;16061697;16639001;17515931;17562024;17596512;18843291;19190773;19194479;20179351;20657595;20667819;20940292;21439340;21654840;21997417;23629652;25926655;26390218;27354280;27671677;27999203;34099859;34826211;7543090;8824274;8999895;9395522;9565599",
        "class_list": "",
        "function": "A significant fraction of SPINK6-sensitive proteases in healthy saliva and confirmed the ability of gingipains to inactivate SPINK6 under ex vivo conditions, [RefSeq, PubMed]; Data suggest that SPINK6 plays a role in modulating the activity of kallikreins in human skin., [RefSeq, PubMed]; Our results identified a novel EGFR-activating mechanism in which SPINK6 has a critical role in promoting nasopharyngeal carcinoma metastasis, [RefSeq, PubMed]; SPINK6 inhibits human airway serine proteases and restricts influenza virus activation., [RefSeq, PubMed]; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8., [UniProtKB, PubMed, PubMed]; Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium. Publication Status: Online-Only, [RefSeq, PubMed]; Study showed that the expression of SPINK6 is specifically suppressed in liver tumor tissues. The suppression could be even detected in the early stage tumors. As SPINK6 is a secretory protein, the extracellular protein level may be decreased because of tumor development. These results support that SPINK6 is an important tumor suppressor in liver., [RefSeq, PubMed]; The protein encoded by this gene is a Kazal-type serine protease inhibitor that acts on kallikrein-related peptidases in the skin. Two transcript variants the same protein have been found for this gene. [provided by RefSeq, Aug 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E0X656;Q8N5P0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0045861 negative regulation of proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 4.6,
        "record_id": "Q6UWN8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q969I3-1",
        "uniprot_id": "GLYL1_HUMAN",
        "mass": 35101.0,
        "length": 302,
        "protein_name": "Glycine N-acyltransferase-like protein 1",
        "gene_name": "GLYATL1",
        "organism": "Human",
        "refseq_name": "glycine N-acyltransferase-like protein 1 isoform 2",
        "refseq_ac": "NP_001207423",
        "gene_names_uniprotkb": "GLYATL1; GNAT",
        "gene_names_refseq": "GATF-C; GLYATL1; GNAT",
        "protein_names_uniprotkb": "Glycine N-acyltransferase-like protein 1; 2.3.1.68; Acyl-CoA:glycine N-acyltransferase-like protein 1; Glutamine N-acyltransferase",
        "protein_names_refseq": "acyl-CoA:glycine N-acyltransferase-like protein 1; glutamine N-acyltransferase; glycine N-acyltransferase-like protein 1 isoform 2; glycine N-acyltransferase-like protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:92292);  (R-HSA-159424);  (R-HSA-177128);  (R-HSA-177135);  (R-HSA-9749641)",
        "pathway_count": 5,
        "publication_count": 33,
        "publication_id_list": "10220572;10434065;11237011;11581266;12616642;13741103;16258079;16837570;16858120;16943252;17482904;1783992;19836360;22475485;22674043;25840124;28677105;31154438;31376196;3342084;35051231;35580925;3705620;5013373;5773090;5862532;6777177;6838677;7206363;7802672;9144407;931988;975718",
        "class_list": "",
        "function": "Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor., [UniProtKB, PubMed]; Study characterizes the expression of glycine-N-acyltransferase like 1(GLYATL1) in prostate cancer and explores its regulation in prostate cancer, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NDT0;Q7Z510;Q8NAW8",
        "ec_number_list": "2.3.1.68;2.3.1.13;2.3.1.-;2.3.1.71",
        "go_molecular_function": "GO:0047946 glutamine N-acyltransferase activity;GO:0047961 glycine N-acyltransferase activity",
        "go_cellular_component": "GO:0005739 mitochondrion",
        "go_biological_process": "GO:0006541 glutamine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q969I3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14005-1",
        "uniprot_id": "IL16_HUMAN",
        "mass": 141752.0,
        "length": 1332,
        "protein_name": "Pro-interleukin-16",
        "gene_name": "IL16",
        "organism": "Human",
        "refseq_name": "pro-interleukin-16 isoform 3",
        "refseq_ac": "NP_001165599",
        "gene_names_uniprotkb": "IL16",
        "gene_names_refseq": "IL16; LCF; NIL16; PRIL16; prIL-16",
        "protein_names_uniprotkb": "Pro-interleukin-16; LCF; Lymphocyte chemoattractant factor",
        "protein_names_refseq": "lymphocyte chemoattractant factor; neuronal interleukin 16; pro-interleukin-16 isoform 3; prointerleukin 16",
        "tax_id": 9606,
        "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); prostate cancer (Disease Ontology:DOID:10283); asthma (Disease Ontology:DOID:2841); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); periodontal disease (Disease Ontology:DOID:3388); rhinitis (Disease Ontology:DOID:4483); borna disease (Disease Ontology:DOID:5154); chronic fatigue syndrome (Disease Ontology:DOID:8544)",
        "pathway": " (hsa:3603);  (R-HSA-449836)",
        "pathway_count": 2,
        "publication_count": 105,
        "publication_id_list": "10395686;10438516;11032842;11237011;11276202;11466336;12450396;12469119;12558796;12620798;12923170;14734747;14768064;15104674;16488976;16492764;17308301;18097041;18467591;18991276;19906316;20058876;20166139;2147944;21716315;23291588;23481700;23744080;24275569;24366607;25418920;25469497;25576301;25645385;25662098;25892735;26095744;26154972;26375851;26758079;26811146;26929215;26992070;27600516;27655845;27846572;27862975;27920218;28063628;28228285;28832583;28834231;28860189;28904123;29242379;29351928;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30410026;31092671;31154438;31217245;31530632;31844290;31848261;31998317;32157095;32350084;32357974;32387766;32488085;32502341;32983136;33298915;33633747;33717175;33912179;33936100;33968037;34357683;34509645;34932366;35051231;35580925;36284347;37938771;38544694;38760468;38771670;39137872;39408600;6729885;7615501;7805849;7910967;8609984;9422780;9699630;9990060",
        "class_list": "",
        "function": "Association of the Single Nucleotide Polymorphisms rs11556218, rs4778889, rs4072111, and rs1131445 of the Interleukin-16 Gene with Ovarian Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Correlations between increased levels of secreted IL-16, CD4+ Th1 cell inflammation, and phosphorylation of axonal cytoskeleton in Multiple sclerosis (MS) lesions. Possible role for IL-16 in regulation of inflammation and axonal cytoskeleton in MS., [RefSeq, PubMed]; Enhanced interleukin-16-CD4 signaling in CD3 T cell mediates neuropathic pain via activating astrocytes in female mice., [RefSeq, PubMed]; Genetic Association of Interleukin 16 Gene Polymorphisms (rs11556218 & rs4778889) with Type 1 Diabetes in Egyptian Children: A Case-Control Study., [RefSeq, PubMed]; Interleukin-16 is increased in dialysis patients but is not a cardiovascular risk factor. Publication Status: Online-Only, [RefSeq, PubMed]; Interleukin-16 is increased in obesity and alters adipogenesis and inflammation in vitro. Publication Status: Online-Only, [RefSeq, PubMed]; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells., [UniProtKB]; May act as a scaffolding protein that anchors ion channels in the membrane., [UniProtKB]; The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 48,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 11,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NM20;A8MU65;B5TY35;B9EGR6;H3BVH5;Q16435;Q6VVE6;Q6ZMQ7;Q9UP18",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042609 CD4 receptor binding;GO:0005125 cytokine activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005634 nucleus",
        "go_biological_process": "GO:0032730 positive regulation of interleukin-1 alpha production;GO:0006351 DNA-templated transcription;GO:0006935 chemotaxis;GO:0006955 immune response;GO:0032755 positive regulation of interleukin-6 production",
        "synthesized_glycan_count": 0,
        "hit_score": 11.0,
        "record_id": "Q14005-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96P70-1",
        "uniprot_id": "IPO9_HUMAN",
        "mass": 115963.0,
        "length": 1041,
        "protein_name": "Importin-9",
        "gene_name": "IPO9",
        "organism": "Human",
        "refseq_name": "importin-9",
        "refseq_ac": "NP_060555",
        "gene_names_uniprotkb": "IPO9; HSPC273; IMP9; KIAA1192; RANBP9",
        "gene_names_refseq": "IPO9; Imp9",
        "protein_names_uniprotkb": "Importin-9; Imp9; Ran-binding protein 9; RanBP9",
        "protein_names_refseq": "importin-9; ran-binding protein 9; ranBP9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55705)",
        "pathway_count": 1,
        "publication_count": 97,
        "publication_id_list": "11237011;11823430;12670497;18691976;20068231;22223895;22424782;22544926;22645359;23301498;23481700;23851686;24715725;25576301;25645385;25880248;26154972;26811146;26934847;26992070;27600516;27846572;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632711;29769354;29786170;29789417;30315122;30410026;30429286;30524438;30573663;30779550;30855230;31092671;31154438;31217245;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34357683;34405274;34509645;34561969;34711951;34725712;35051231;35318648;35580925;36010968;36215666;36241641;36284347;36477533;37217939;40914422",
        "class_list": "",
        "function": "CFL1 itself does not translocate actin into the cell nucleus but this transport requires the functional expression of IPO9., [RefSeq, PubMed]; IPO9 associates with 2 stable stem-loop structures of the IFN-epsilon 5'UTR. IPO9 overexpression decreased, and IPO9 silencing increased basal IFN-epsilon expression., [RefSeq, PubMed]; Like many histone chaperones, which prevent inappropriate non-nucleosomal interactions, Importin-9 also sequesters H2A-H2B from DNA. Importin-9 appears to act as a storage chaperone for H2A-H2B while escorting it to the nucleus. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear transport receptor that mediates nuclear import of proteins, such as histones, proteasome and actin (PubMed:11823430, PubMed:30855230, PubMed:34711951). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the import of pre-assembled proteasomes into the nucleus; AKIRIN2 acts as a molecular bridge between IPO9 and the proteasome complex (PubMed:11823430, PubMed:34711951). Mediates the nuclear import of histones H2A, H2B, H4 and H4 (PubMed:11823430, PubMed:30855230). In addition to nuclear import, also acts as a chaperone for histones by preventing inappropriate non-nucleosomal interactions (PubMed:30855230). Mediates the nuclear import of actin (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Specific interaction between a member of the importin beta/karyopherin beta superfamily, importin 9, and the A subunit of PP2A (PR65), [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1ASV5;Q8N1Y1;Q8N3I2;Q8NCG9;Q96SU6;Q9NW01;Q9P0A8;Q9ULM8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031267 small GTPase binding;GO:0042393 histone binding;GO:0061608 nuclear import signal receptor activity;GO:0140713 histone chaperone activity",
        "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0006606 protein import into nucleus;GO:0031144 proteasome localization",
        "synthesized_glycan_count": 0,
        "hit_score": 10.0,
        "record_id": "Q96P70-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P48547-1",
        "uniprot_id": "KCNC1_HUMAN",
        "mass": 57942.0,
        "length": 511,
        "protein_name": "Voltage-gated potassium channel KCNC1",
        "gene_name": "KCNC1",
        "organism": "Human",
        "refseq_name": "voltage-gated potassium channel KCNC1 isoform 1",
        "refseq_ac": "NP_001106212",
        "gene_names_uniprotkb": "KCNC1",
        "gene_names_refseq": "EPM7; KCNC1; KV3.1; KV4; NGK2",
        "protein_names_uniprotkb": "Voltage-gated potassium channel KCNC1; NGK2; Potassium voltage-gated channel subfamily C member 1; Voltage-gated potassium channel subunit Kv3.1; Voltage-gated potassium channel subunit Kv4",
        "protein_names_refseq": "potassium channel, voltage gated Shaw related subfamily C, member 1; voltage-gated potassium channel KCNC1 isoform 1; voltage-gated potassium channel KCNC1; voltage-gated potassium channel protein KV3.1; voltage-gated potassium channel subunit Kv4",
        "tax_id": 9606,
        "disease": "progressive myoclonus epilepsy 7 (Disease Ontology:DOID:0111447)",
        "pathway": " (hsa:3746);  (R-HSA-1296072)",
        "pathway_count": 2,
        "publication_count": 16,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;1400413;1432046;20393197;21231794;23734863;25401298;29393594;29769354;34105734;34232791;34830172;35840580;36419348;8449507",
        "class_list": "",
        "function": "A KCNC1 mutation in epilepsy of infancy with focal migrating seizures produces functional channels that fail to be regulated by PKC phosphorylation., [RefSeq, PubMed]; A KCNC1-related neurological disorder due to gain of Kv3.1 function., [RefSeq, PubMed]; Cross Pharmacological, Biochemical and Computational Studies of a Human Kv3.1b Inhibitor from Androctonus australis Venom. Publication Status: Online-Only, [RefSeq, PubMed]; Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain. Publication Status: Online-Only, [RefSeq, PubMed]; Describes two rat isoforms of Kv3.1, alpha is the longer one and beta is the shorter one, [RefSeq, PubMed]; Methylation gene KCNC1 is associated with overall survival in patients with seminoma., [RefSeq, PubMed]; This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both 'b' and 'alpha', while the shorter isoform has been called both 'a' and 'beta' (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014]., [RefSeq]; Voltage-gated potassium channel that opens in response to the voltage difference across the membrane and through which potassium ions pass in accordance with their electrochemical gradient (PubMed:25401298, PubMed:35840580). The mechanism is time-dependent and inactivation is slow (By similarity). Plays an important role in the rapid repolarization of fast-firing brain neurons (By similarity). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well (By similarity). Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "K4DI87;Q3KNS8",
        "ec_number_list": "1.8.-.-",
        "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0044325 transmembrane transporter binding;GO:0019894 kinesin binding;GO:0005249 voltage-gated potassium channel activity;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential",
        "go_cellular_component": "GO:0044305 calyx of Held;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043679 axon terminus;GO:0045211 postsynaptic membrane",
        "go_biological_process": "GO:1990089 response to nerve growth factor;GO:0051260 protein homooligomerization;GO:0051262 protein tetramerization;GO:0001508 action potential;GO:0071466 cellular response to xenobiotic stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "P48547-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q1ZYL8-1",
        "uniprot_id": "IZUM4_HUMAN",
        "mass": 26510.0,
        "length": 232,
        "protein_name": "Izumo sperm-egg fusion protein 4",
        "gene_name": "IZUMO4",
        "organism": "Human",
        "refseq_name": "izumo sperm-egg fusion protein 4 isoform 1 precursor",
        "refseq_ac": "NP_001026905",
        "gene_names_uniprotkb": "IZUMO4; C19orf36; PRO1758",
        "gene_names_refseq": "C19orf36; IMAGE:4215339; IZUMO4",
        "protein_names_uniprotkb": "Izumo sperm-egg fusion protein 4; Sperm 22 kDa protein c113",
        "protein_names_refseq": "izumo sperm-egg fusion protein 4 isoform 1 precursor; izumo sperm-egg fusion protein 4; sperm 22 kDa protein c113",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:113177);  (R-HSA-1300645)",
        "pathway_count": 2,
        "publication_count": 9,
        "publication_id_list": "11080640;11237011;12975309;19335925;19658160;28904123;31844290;32350084;33912179",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7RA93;A7RA94;Q6UXA2;Q96FT6;Q96L02",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q1ZYL8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5VZ46-1",
        "uniprot_id": "K1614_HUMAN",
        "mass": 126604.0,
        "length": 1190,
        "protein_name": "Uncharacterized protein KIAA1614",
        "gene_name": "KIAA1614",
        "organism": "Human",
        "refseq_name": "uncharacterized protein KIAA1614 isoform 2",
        "refseq_ac": "NP_066001",
        "gene_names_uniprotkb": "KIAA1614",
        "gene_names_refseq": "KIAA1614",
        "protein_names_uniprotkb": "Uncharacterized protein KIAA1614",
        "protein_names_refseq": "uncharacterized protein KIAA1614 isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57710)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "11237011;19413330;26992070;29557506;37074911",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 9781,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VZ45;Q9HCF8",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005938 cell cortex;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0060341 regulation of cellular localization;GO:0007098 centrosome cycle;GO:0007163 establishment or maintenance of cell polarity",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q5VZ46-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q06136-1",
        "uniprot_id": "KDSR_HUMAN",
        "mass": 36187.0,
        "length": 332,
        "protein_name": "3-ketodihydrosphingosine reductase",
        "gene_name": "KDSR",
        "organism": "Human",
        "refseq_name": "3-ketodihydrosphingosine reductase",
        "refseq_ac": "NP_002026",
        "gene_names_uniprotkb": "KDSR; FVT1; SDR35C1",
        "gene_names_refseq": "DHSR; EKVP4; FVT1; KDSR; SDR35C1",
        "protein_names_uniprotkb": "3-ketodihydrosphingosine reductase; 1.1.1.102; 3-dehydrosphinganine reductase; FVT-1; Follicular variant translocation protein 1; KDS reductase; Short chain dehydrogenase/reductase family 35C member 1",
        "protein_names_refseq": "3-dehydrosphinganine reductase; 3-ketodihydrosphingosine reductase; FVT-1; KDS reductase; follicular lymphoma variant translocation 1; follicular variant translocation protein 1; short chain dehydrogenase/reductase family 35C member 1",
        "tax_id": 9606,
        "disease": "follicular lymphoma (Disease Ontology:DOID:0050873); erythrokeratodermia variabilis et progressiva 4 (Disease Ontology:DOID:0080250); thrombocytopenia (Disease Ontology:DOID:1588); liver disease (Disease Ontology:DOID:409)",
        "pathway": " (hsa:2531);  (R-HSA-1660661)",
        "pathway_count": 2,
        "publication_count": 120,
        "publication_id_list": "10722674;10751414;10802064;10947957;11237011;11937514;14685229;14685263;14976195;15063729;15328338;15337768;16100120;16118219;16571669;16793762;16895911;17023427;17050692;17331073;17355976;17449912;17591919;17982138;18165232;18165233;18184806;19005213;19141869;19233134;19416851;19506037;20061445;20110355;20182505;21620961;22517924;22970244;23180825;23481700;23602659;23754960;24569996;24715725;24782409;25576301;25645385;25788259;25892735;26154972;26375851;26992070;27600516;27920218;28228285;28575652;28774589;28832583;28904123;29242379;29393594;29557506;29563527;29769354;29799648;30315122;30429286;30467204;31844290;31895563;31987885;32157095;32350084;32357974;32387766;32488085;32897882;32938616;32983136;33141586;33298915;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34211107;34277909;34357683;34373586;34405274;34509645;34686882;35051231;35251023;35409383;35580925;35958175;36010968;36170811;36215666;36241641;36263748;36546314;36581221;36902339;36907437;37224812;37390971;37938771;38253038;40596516;4339164;4817756;8417785;9188692;9312549;9363775",
        "class_list": "glycogene",
        "function": "Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Depletion of kdsr causes thrombocytopenia due to impaired proplatelet formation and sphingolipid dysregulation., [RefSeq, PubMed]; FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane, [RefSeq, PubMed]; Formation of keto-type ceramides in palmoplantar keratoderma based on biallelic KDSR mutations in patients., [RefSeq, PubMed]; The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 340,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5Y1;B4DMX0",
        "ec_number_list": "1.1.1.102",
        "go_molecular_function": "GO:0047560 3-dehydrosphinganine reductase activity;GO:0070402 NADPH binding;GO:0000166 nucleotide binding",
        "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006666 3-keto-sphinganine metabolic process;GO:0006686 sphingomyelin biosynthetic process;GO:0006688 glycosphingolipid biosynthetic process;GO:0046513 ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 12.3,
        "record_id": "Q06136-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6P2M8-1",
        "uniprot_id": "KCC1B_HUMAN",
        "mass": 38500.0,
        "length": 343,
        "protein_name": "Calcium/calmodulin-dependent protein kinase type 1B",
        "gene_name": "PNCK",
        "organism": "Human",
        "refseq_name": "calcium/calmodulin-dependent protein kinase type 1B isoform a",
        "refseq_ac": "NP_001034671",
        "gene_names_uniprotkb": "PNCK",
        "gene_names_refseq": "BSTK3; CaMK1b; PNCK",
        "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type 1B; 2.7.11.17; CaM kinase I beta; CaM kinase IB; CaM-KI beta; CaMKI-beta; Pregnancy up-regulated non-ubiquitously-expressed CaM kinase",
        "protein_names_refseq": "caM kinase I beta; caM kinase IB; caM-KI beta; caMKI-beta; calcium/calmodulin-dependent protein kinase type 1B isoform a; calcium/calmodulin-dependent protein kinase type 1B; pregnancy up-regulated non-ubiquitously-expressed CaM kinase; pregnancy upregulated non-ubiquitously expressed CaM kinase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:139728)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;17344846;18562482;21325639;23634203;24714562;25773930;27862975;29557506;33099476;33717175",
        "class_list": "",
        "function": "Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity)., [UniProtKB]; Expression of Pregnancy Up-regulated Non-ubiquitous Calmodulin Kinase (PNCK) in Hepatocellular Carcinoma., [RefSeq, PubMed]; PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008]., [RefSeq]; Pnck induces epidermal growth factor receptor degradation, most likely through perturbation of Hsp90 chaperone activity due to Hsp90 phosphorylation.  Epidermal growth factor receptor degradation is coupled to proteasomal degradation of Pnck., [RefSeq, PubMed]; Pnck induces ligand-independent EGFR degradation, and it may represent an attractive therapeutic target in EGFR-regulated oncogenesis., [RefSeq, PubMed]; Pnck may be a marker of Trastuzumab resistance and possibly a therapeutic target in breast cancer., [RefSeq, PubMed]; The relationship between PNCK and prognosis in clear cell renal cell carcinoma Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DJR8;B4E1A6;B7WPG0;D3DWU7;Q8N4R0",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0106310 protein serine kinase activity;GO:0004672 protein kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q6P2M8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P26440-1",
        "uniprot_id": "IVD_HUMAN",
        "mass": 46651.0,
        "length": 426,
        "protein_name": "Isovaleryl-CoA dehydrogenase, mitochondrial",
        "gene_name": "IVD",
        "organism": "Human",
        "refseq_name": "isovaleryl-CoA dehydrogenase, mitochondrial isoform 1 precursor",
        "refseq_ac": "NP_002216",
        "gene_names_uniprotkb": "IVD",
        "gene_names_refseq": "ACAD2; IVDH; IVD",
        "protein_names_uniprotkb": "Isovaleryl-CoA dehydrogenase, mitochondrial; 1.3.8.1; 1.3.8.4; Butyryl-CoA dehydrogenase; IVD",
        "protein_names_refseq": "butyryl-CoA dehydrogenase; epididymis secretory sperm binding protein; isovaleryl Coenzyme A dehydrogenase; isovaleryl-CoA dehydrogenase, mitochondrial isoform 1 precursor; isovaleryl-CoA dehydrogenase, mitochondrial",
        "tax_id": 9606,
        "disease": "isovaleric acidemia (Disease Ontology:DOID:14753); amino acid metabolic disorder (Disease Ontology:DOID:9252)",
        "pathway": " (hsa:3712);  (R-HSA-70895);  (R-HSA-9914355)",
        "pathway_count": 3,
        "publication_count": 88,
        "publication_id_list": "10677295;10832746;10947204;11013134;11181649;11237011;11264579;11406611;11738050;12269802;12359132;12434311;12665801;12696021;1310317;13416257;14752098;15166214;1527093;15342248;15576032;16023992;16141215;17371050;19608861;20068231;2063866;22004070;22291014;22350545;22956686;2318964;23485643;23587913;24449431;25418920;25576301;25892735;26251176;26375851;26929215;27600516;27904153;28218747;28535199;28832583;28834231;29242379;29557506;29632046;29769354;30315122;30524438;3082934;31435015;31844290;32157095;32357974;32387766;32938616;33141586;33298915;33592498;33936100;33968037;34171305;34185709;34357683;34509645;34561969;35051231;35580925;3597357;36010968;36241641;37702673;37938771;38665916;40914422;6928646;7356336;7640268;8468053;8824301;9165094;9214289;9665741;9889013",
        "class_list": "",
        "function": "A Case Report of a Novel Isovaleryl-CoA Dehydrogenase Gene Mutation in a Chinese Family with Isovaleric Acidemia., [RefSeq, PubMed]; A mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism, where isovaleryl-CoA (3-methylbutanoyl-CoA) is metabolized to 3-methylbut-2-enoyl-CoA. To a lesser extent, it also participates in the first step in fatty acid beta-oxidation, in which it catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of other saturated short-chain acyl-CoA thioesters such as pentanoyl-CoA, hexanoyl-CoA and butanoyl-CoA, using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]., [RefSeq]; Nine novel isovaleryl-CoA dehydrogenase mutations have been found in a Spanish cohort with isovaleric acidemia., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCV5;B3KVI7;J3KR54;Q53XZ9;Q96AF6",
        "ec_number_list": "1.3.8.7;1.3.8.1;1.3.8.4;1.3.8.8;1.3.8.5",
        "go_molecular_function": "GO:0008470 3-methylbutanoyl-CoA dehydrogenase activity;GO:0042802 identical protein binding;GO:0050660 flavin adenine dinucleotide binding;GO:0016937 short-chain fatty acyl-CoA dehydrogenase activity;GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane",
        "go_biological_process": "GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0009083 branched-chain amino acid catabolic process;GO:0006552 L-leucine catabolic process;GO:0019752 carboxylic acid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.1,
        "record_id": "P26440-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5MCW4-1",
        "uniprot_id": "ZN569_HUMAN",
        "mass": 79583.0,
        "length": 686,
        "protein_name": "Zinc finger protein 569",
        "gene_name": "ZNF569",
        "organism": "Human",
        "refseq_name": "zinc finger protein 569 isoform 2",
        "refseq_ac": "NP_001317411",
        "gene_names_uniprotkb": "ZNF569",
        "gene_names_refseq": "ZAP1; ZNF569; ZNF; Zfp74",
        "protein_names_uniprotkb": "Zinc finger protein 569",
        "protein_names_refseq": "DNA-binding protein; zinc finger protein 569 isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:148266);  (R-HSA-212436)",
        "pathway_count": 2,
        "publication_count": 24,
        "publication_id_list": "10235266;10330177;11237011;11395415;14519192;1505991;15175151;15896744;16606702;16719718;16793018;16959974;2163759;26992070;28063628;29632046;31844290;32387766;32938616;33717175;8183939;8769649;9637681;9653119",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]; ZNF569 protein may act as a transcriptional repressor that suppresses MAPK signaling pathway to mediate cellular functions, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K1S2;Q15925;Q17RR6;Q96MQ2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "Q5MCW4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6IQ16-1",
        "uniprot_id": "SPOPL_HUMAN",
        "mass": 44647.0,
        "length": 392,
        "protein_name": "Speckle-type POZ protein-like",
        "gene_name": "SPOPL",
        "organism": "Human",
        "refseq_name": "speckle-type POZ protein-like",
        "refseq_ac": "NP_001001664",
        "gene_names_uniprotkb": "SPOPL",
        "gene_names_refseq": "BTBD33; SPOPL",
        "protein_names_uniprotkb": "Speckle-type POZ protein-like; HIB homolog 2; Roadkill homolog 2",
        "protein_names_refseq": "HIB homolog 2; roadkill homolog 2; speckle-type POZ protein-like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:339745);  (R-HSA-5632684)",
        "pathway_count": 2,
        "publication_count": 123,
        "publication_id_list": "10433824;10564661;10966113;11027307;11237011;11960000;12050670;12068298;12123571;12138125;12426310;14528312;14611647;15115751;15198976;15300262;16061793;16136078;16155214;16421275;16459297;16459298;16611981;16651542;16740475;16980583;17115028;17442700;17641202;18455992;18497258;18827223;18832070;19305393;19368795;19371734;19533801;19549984;19592253;19622347;19666503;19684112;19818708;19852954;19878745;19955409;19996169;20014402;20016067;20154143;20360384;20460306;20487519;20512148;20643644;20818436;20844016;20889716;20956384;21695114;21801010;21878643;22007132;22391301;22632832;22982193;23332756;23719536;23725801;23955340;24072710;24302888;24582806;24845016;24854174;24925320;25576301;26375851;26811146;26992070;27008177;27862975;28063628;28218747;28228285;28832583;28904123;29242379;29331515;29393594;29437277;29557506;29632046;29786170;30315122;30379171;30410026;30429286;30779550;30833945;31154438;31530632;31844290;31848261;32157095;32387766;32502341;32897882;32938616;32983136;33298915;33717175;33912179;33968037;34171305;35051231;35580925;36010968;36284347;37523046;37938771;9601642;9874371",
        "class_list": "",
        "function": "Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP., [UniProtKB, PubMed]; SPOPL induces tumorigenicity and stemness in glioma stem cells by activating Notch signaling., [RefSeq, PubMed]; Together, the data indicate that a CUL3-SPOPL E3 ubiquitin ligase complex regulates endocytic trafficking and formation of multivesicular bodies by ubiquitinating and degrading EPS15 at endosomes. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex",
        "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030162 regulation of proteolysis;GO:0016567 protein ubiquitination;GO:0031397 negative regulation of protein ubiquitination;GO:0030163 protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 12.6,
        "record_id": "Q6IQ16-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NY64-1",
        "uniprot_id": "SL2A8_HUMAN",
        "mass": 50819.0,
        "length": 477,
        "protein_name": "Solute carrier family 2, facilitated glucose transporter member 8",
        "gene_name": "SLC2A8",
        "organism": "Human",
        "refseq_name": "solute carrier family 2, facilitated glucose transporter member 8 isoform 2",
        "refseq_ac": "NP_001258640",
        "gene_names_uniprotkb": "SLC2A8; GLUT8; GLUTX1",
        "gene_names_refseq": "GLUT8; GLUTX1; SLC2A8",
        "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 8; GLUT-8; Glucose transporter type 8; Glucose transporter type X1",
        "protein_names_refseq": "glucose transporter type 8; glucose transporter type X1; solute carrier family 2 (facilitated glucose transporter), member 8; solute carrier family 2, facilitated glucose transporter member 8 isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:29988);  (R-HSA-189200);  (R-HSA-8856825);  (R-HSA-8856828)",
        "pathway_count": 4,
        "publication_count": 266,
        "publication_id_list": "10097102;10436022;10535736;10542231;10559856;10559861;10559924;10567358;10613896;10625686;10671487;10766823;10769163;10821868;10860667;10970791;10983987;10987651;11071885;11076969;11082044;11133510;11231140;11237011;11239472;11245466;11247302;11247674;11425315;11454741;11470803;11516654;11517213;11532990;11577110;11583593;11588219;11681785;11741323;11780755;11832379;11845330;11877457;11877461;11889126;11919637;11927540;11988742;11994746;12057195;12086608;12213833;12221107;12234931;12429842;12447393;12451172;12464600;12504846;12590146;12717448;12847086;12885248;12944396;12952949;12958364;1317852;1415574;14555962;14581451;14614622;14617351;14622578;14622579;14662753;14726597;14739288;14997204;15033637;15134832;15252009;15260957;15318165;15339664;1535555;15473838;15502812;15502813;15607332;15649145;15671180;15703209;15728179;15802264;15895077;15902306;15916959;16103228;16154905;16159959;16215232;16326391;16410077;16459302;16460808;16516836;16550171;16707488;16723738;16798879;16880396;16903783;17018281;17035995;17050778;17158794;17267500;17360967;17456551;17494869;17512409;17522231;17540576;1756912;17609109;17635959;17681954;17713526;17762867;17765681;17978091;18032517;18063724;18093523;18166656;18199683;18327257;18388313;1847920;18775314;18790740;18819912;18981233;19092055;19140243;1918382;19287005;19296720;19458185;19536138;19575674;19603039;1968060;19696796;19696798;19713939;19732400;19776351;19809571;19853559;20033059;20059951;20211604;20231386;20351096;20428113;20448150;20616166;20826345;20946875;21102408;21107422;2115402;21187331;21278753;21316588;21445324;21482805;21499258;21613550;21779028;21841790;21883765;21927000;21927001;21940664;21962517;21995445;22099461;22118466;22212718;22233676;22357968;22484487;22505844;22521588;2257624;22815487;22863004;22942912;23297414;23536704;23823722;23861397;23891661;24130457;24186068;24384571;24519932;24581490;24680432;24746795;24789820;24966051;25107275;25303366;25341920;26042225;26154972;26403691;2656669;26650681;26829388;26992070;27160096;27818355;27922102;28218747;28904123;2890644;29437277;29557506;29590129;29632046;31844290;32161166;32387766;32938616;34087483;34171305;3417785;34357683;34509645;35051231;36241641;6146630;7569928;7822302;7877694;8457197;8524399;8552632;8553074;8837779;9092476;9100026;9169477;9303539;9354798;9427626;9428629;9635431;9723620;9736607;9751501;9812899",
        "class_list": "glycogene",
        "function": "GLUT8 is thus essential for hepatocyte fructose transport and fructose-induced macrosteatosis., [RefSeq, PubMed]; Glucose/fructose is transported into the cytoplasm of vimentin- or GFAP-positive astrocytic and CD68- or HLA-DR-positive microglial cells located around the lateral ventricle, [RefSeq, PubMed]; Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction Publication Status: Online-Only, [RefSeq, PubMed]; Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose (By similarity). Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1 (PubMed:27922102). Also able to mediate the transport of dehydroascorbate., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; The findings support the hypothesis of the transport of intravascularGLUT8 through the epithelial cells of the choroid plexus and the ependymal cells., [RefSeq, PubMed]; The recruitment of GLUT8 to the endocytic machinery occurs via direct interaction of the dileucine motif with beta2-adaptin, and that endocytosis might be the main site at which GLUT8 is likely to be regulated., [RefSeq, PubMed]; These data suggest that cytoplasmic trehalose access is carrier-mediated, and that GLUT8 is a mammalian trehalose transporter required for hepatocyte trehalose-induced autophagy and signal transduction. Publication Status: Online-Only, [RefSeq, PubMed]; This carrier protein is expressed in human tissues of the testis in a gonadotropin-dependent manner., [RefSeq, PubMed]; This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 647,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8WUZ9;Q9NSC4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0005353 fructose transmembrane transporter activity;GO:0005536 D-glucose binding;GO:0055056 D-glucose transmembrane transporter activity;GO:0022857 transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0030669 clathrin-coated endocytic vesicle membrane;GO:0008021 synaptic vesicle",
        "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0005975 carbohydrate metabolic process;GO:0015755 fructose transmembrane transport;GO:0007141 male meiosis I",
        "synthesized_glycan_count": 0,
        "hit_score": 26.7,
        "record_id": "Q9NY64-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5SZD4-1",
        "uniprot_id": "GLYL3_HUMAN",
        "mass": 32704.0,
        "length": 288,
        "protein_name": "Glycine N-acyltransferase-like protein 3",
        "gene_name": "GLYATL3",
        "organism": "Human",
        "refseq_name": "glycine N-acyltransferase-like protein 3",
        "refseq_ac": "NP_001010904",
        "gene_names_uniprotkb": "GLYATL3; C6orf140",
        "gene_names_refseq": "C6orf140; GLYATL3; bA28H17.2",
        "protein_names_uniprotkb": "Glycine N-acyltransferase-like protein 3; 2.3.1.13; Acyl-CoA:glycine-N-acyltransferase-like protein 3",
        "protein_names_refseq": "acyl-CoA:glycine-N-acyltransferase-like protein 3; glycine N-acyltransferase-like protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:389396);  (R-HSA-159424);  (R-HSA-177128);  (R-HSA-177135);  (R-HSA-9749641)",
        "pathway_count": 5,
        "publication_count": 30,
        "publication_id_list": "10220572;10434065;11237011;11581266;12616642;13741103;16258079;16837570;16858120;16943252;17482904;1783992;19836360;22475485;22674043;25840124;28228285;28677105;3342084;3705620;5013373;5773090;5862532;6777177;6838677;7206363;7802672;9144407;931988;975718",
        "class_list": "",
        "function": "Catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, an intermediate in the primary fatty acid amide biosynthetic pathway., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "2.3.1.13;2.3.1.-;2.3.1.71;2.3.1.68",
        "go_molecular_function": "GO:0047961 glycine N-acyltransferase activity",
        "go_cellular_component": "GO:0005739 mitochondrion",
        "go_biological_process": "GO:0006629 lipid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "Q5SZD4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6IB77-1",
        "uniprot_id": "GLYAT_HUMAN",
        "mass": 33924.0,
        "length": 296,
        "protein_name": "Glycine N-acyltransferase",
        "gene_name": "GLYAT",
        "organism": "Human",
        "refseq_name": "glycine N-acyltransferase isoform b",
        "refseq_ac": "NP_005829",
        "gene_names_uniprotkb": "GLYAT; ACGNAT; CAT; GAT",
        "gene_names_refseq": "ACGNAT; GAT; GLYAT",
        "protein_names_uniprotkb": "Glycine N-acyltransferase; 2.3.1.13; 2.3.1.71; AAc; Acyl-CoA:glycine N-acyltransferase; Aralkyl acyl-CoA N-acyltransferase; Aralkyl acyl-CoA:amino acid N-acyltransferase; Benzoyl-coenzyme A:glycine N-acyltransferase; Glycine N-benzoyltransferase; HRP-1(CLP)",
        "protein_names_refseq": "AAc; HRP-1(CLP); acyl-CoA:glycine N-acyltransferase; aralkyl acyl-CoA N-acyltransferase; aralkyl acyl-CoA:amino acid N-acyltransferase; aralkyl-CoA N-acyltransferase; benzoyl-coenzyme A:glycine N-acyltransferase; epididymis secretory sperm binding protein; glycine N-acyltransferase isoform b; glycine N-benzoyltransferase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10249);  (R-HSA-159424);  (R-HSA-177128);  (R-HSA-177135);  (R-HSA-70895);  (R-HSA-9749641)",
        "pathway_count": 6,
        "publication_count": 70,
        "publication_id_list": "10220572;10434065;10630424;10832746;10947204;11013134;11181649;11237011;11264579;11406611;11581266;11738050;12269802;12359132;12434311;12616642;12696021;13416257;13741103;14752098;15166214;1527093;15342248;15576032;16023992;16141215;16258079;16837570;16858120;16943252;17371050;17482904;1783992;19836360;22291014;22475485;22674043;22956686;23485643;24449431;25840124;26251176;28677105;28759163;29557506;3082934;31435015;3342084;33567294;33803916;35051231;3597357;3705620;40596516;5013373;5773090;5862532;6777177;6838677;6928646;7206363;7356336;7802672;8824301;9144407;9165094;9214289;931988;975718;9889013",
        "class_list": "",
        "function": "Frequent sequence variants of human glycine N-acyltransferase (GLYAT) and inborn errors of metabolism., [RefSeq, PubMed]; Functional Characterisation of Three Glycine N-Acyltransferase Variants and the Effect on Glycine Conjugation to Benzoyl-CoA. Publication Status: Online-Only, [RefSeq, PubMed]; GLYAT exhibits mechanistic kinetic cooperativity towards its substrate glycine., [RefSeq, PubMed]; Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid., [UniProtKB, PubMed, PubMed]; The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "H1AE11;O14833;Q96QK7",
        "ec_number_list": "2.3.1.13;2.3.1.-;2.3.1.71;2.3.1.68",
        "go_molecular_function": "GO:0047962 glycine N-benzoyltransferase activity;GO:0016746 acyltransferase activity;GO:0047961 glycine N-acyltransferase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0006805 xenobiotic metabolic process;GO:0009636 response to toxic substance;GO:0006544 glycine metabolic process;GO:0032787 monocarboxylic acid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.3,
        "record_id": "Q6IB77-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6IC98-1",
        "uniprot_id": "GRAM4_HUMAN",
        "mass": 66408.0,
        "length": 578,
        "protein_name": "GRAM domain-containing protein 4",
        "gene_name": "GRAMD4",
        "organism": "Human",
        "refseq_name": "GRAM domain-containing protein 4 isoform 1",
        "refseq_ac": "NP_055939",
        "gene_names_uniprotkb": "GRAMD4; DIP; KIAA0767",
        "gene_names_refseq": "DIP; GRAMD4",
        "protein_names_uniprotkb": "GRAM domain-containing protein 4; Death-inducing protein",
        "protein_names_refseq": "GRAM domain-containing protein 4 isoform 1; GRAM domain-containing protein 4; death-inducing-protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23151)",
        "pathway_count": 1,
        "publication_count": 34,
        "publication_id_list": "11237011;11937641;15565177;16225677;17924679;18302964;18477386;18669648;21127500;23388340;25880248;25892735;26992070;28904123;29437277;29493099;29557506;30429286;31844290;32157095;32357974;32387766;32502341;32897882;32938616;33141586;33298915;33912179;34211107;34509645;35051231;35580925;36010968;39302247",
        "class_list": "",
        "function": "GRAMD4 induces changes in Bcl-2 and Bax protein levels Erratum:[Cell Death Differ. 2012 Mar;19(3):552], [RefSeq, PubMed]; GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis (Stanelle et al., 2005 [PubMed 15565177]).[supplied by OMIM, Jan 2011]., [RefSeq]; Localizes to the mitochondria, upregulated following E2F1 induction GeneRIF: DIP induces p53-independent caspase-dependent and -independent apoptosis. DIP is localized in the mitochondria. DIP accumulates upon E2F1 activation., [RefSeq, PubMed]; Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (PubMed:15565177). Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response (By similarity)., [UniProtKB, PubMed, UniProtKB]; The expression of GRAMD4 is up-regulated in hepatocellular carcinoma cell(HCC cell) lines and HCC tissues, and the increased expression is correlated with the clinicopathological characteristics of HCC., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A9IN51;A9IN57;Q68EN0;Q9UGE6;Q9Y4B9",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0034164 negative regulation of toll-like receptor 9 signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "Q6IC98-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ISB3-1",
        "uniprot_id": "GRHL2_HUMAN",
        "mass": 71105.0,
        "length": 625,
        "protein_name": "Grainyhead-like protein 2 homolog",
        "gene_name": "GRHL2",
        "organism": "Human",
        "refseq_name": "grainyhead-like protein 2 homolog isoform 2",
        "refseq_ac": "NP_001317522",
        "gene_names_uniprotkb": "GRHL2; BOM; TFCP2L3",
        "gene_names_refseq": "BOM; DFNA28; ECTDS; GRHL2; PPCD4; TFCP2L3",
        "protein_names_uniprotkb": "Grainyhead-like protein 2 homolog; Brother of mammalian grainyhead; Transcription factor CP2-like 3",
        "protein_names_refseq": "brother of mammalian grainyhead; brother-of-MGR; grainyhead-like 2; grainyhead-like protein 2 homolog isoform 2; grainyhead-like protein 2 homolog; transcription factor CP2-like 3",
        "tax_id": 9606,
        "disease": "autosomal dominant nonsyndromic deafness (Disease Ontology:DOID:0050564); posterior polymorphous corneal dystrophy 4 (Disease Ontology:DOID:0080669); autosomal dominant nonsyndromic deafness 28 (Disease Ontology:DOID:0110557); nail and teeth abnormalities-marginal palmoplantar keratoderma-oral hyperpigmentation syndrome (MONDO:MONDO:0014460)",
        "pathway": " (hsa:79977)",
        "pathway_count": 1,
        "publication_count": 32,
        "publication_id_list": "12175488;12393799;12549979;19015635;20938050;20978075;23254293;25152456;25576301;29242379;29309642;29485866;29499165;29786170;30379171;32157095;32574038;33537174;33981976;34087483;35051231;35132862;35318648;35356893;35580925;35818212;36241641;36284347;36691073;37340703;37761927;38692097",
        "class_list": "",
        "function": "Correlation analysis between CD133, Klk3 and grhl2 expression and tumor characteristics in prostate cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Enhancing Transcriptional Reprogramming of Mesenchymal Glioblastoma with Grainyhead-like 2 and HDAC Inhibitors Leads to Apoptosis and Cell-Cycle Dysregulation. Publication Status: Online-Only, [RefSeq, PubMed]; GRHL2-controlled gene expression networks in luminal breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Grainyhead-like-2, an epithelial master programmer, promotes interferon induction and suppresses breast cancer recurrence., [RefSeq, PubMed]; Hypermethylation of the GRHL2 promoter region is associated with ovarian endometriosis. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).[provided by RefSeq, Mar 2009]., [RefSeq]; Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:25152456, PubMed:29309642). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (By similarity). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia. Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair (By similarity). In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050). In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (PubMed:23254293)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L303;Q6NT03;Q9H8B8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0031490 chromatin DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005911 cell-cell junction;GO:0016020 membrane;GO:0000785 chromatin",
        "go_biological_process": "GO:0090132 epithelium migration;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007155 cell adhesion;GO:0034329 cell junction assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 3.8,
        "record_id": "Q6ISB3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6PXP3-1",
        "uniprot_id": "GTR7_HUMAN",
        "mass": 55728.0,
        "length": 512,
        "protein_name": "Solute carrier family 2, facilitated glucose transporter member 7",
        "gene_name": "SLC2A7",
        "organism": "Human",
        "refseq_name": "solute carrier family 2, facilitated glucose transporter member 7",
        "refseq_ac": "NP_997303",
        "gene_names_uniprotkb": "SLC2A7; GLUT7",
        "gene_names_refseq": "GLUT-7; GLUT7; SLC2A7; hGLUT7",
        "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 7; GLUT-7; Glucose transporter type 7; hGLUT7",
        "protein_names_refseq": "glucose transporter type 7; intestinal facilitative glucose transporter 7; solute carrier family 2 (facilitated glucose transporter), member 7; solute carrier family 2, facilitated glucose transporter member 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:155184);  (R-HSA-189200)",
        "pathway_count": 2,
        "publication_count": 50,
        "publication_id_list": "10821868;10860667;10970791;10987651;11133510;11245466;11247674;11425315;11583593;11681785;11741323;11780755;11832379;11994746;12504846;12590146;12885248;1415574;14614622;14739288;14997204;15033637;15607332;15902306;16154905;16186102;16550171;17050778;1756912;17635959;18063724;18327257;1918382;20616166;21107422;21940664;22212718;22521588;2656669;26650681;28083649;29242379;29548810;32387766;34357683;35051231;35494241;8457197;9354798;9751501",
        "class_list": "glycogene",
        "function": "A hydrophobic residue is a key determinant of fructose transport in SLC2A7, [RefSeq, PubMed]; Probable sugar transporter (PubMed:28083649). Even if its physiological substrate is subject to discussion, it is able to transport glucose and fructose (PubMed:16186102, PubMed:28083649, PubMed:29548810). Does not transport galactose, 2-deoxy-d-glucose and xylose (PubMed:15033637)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; SLC2A7 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Li et al., 2004). This family of transporters shows conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]., [RefSeq]; Unusual substrate specificity and close sequence identity with GLUT5. GLUT7 may represent intermediate between class II GLUTs and class I member GLUT2. Comparison may give key to structural determinants for recognition of fructose as a substrate., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 745,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A333",
        "ec_number_list": "",
        "go_molecular_function": "GO:0051119 sugar transmembrane transporter activity;GO:0005353 fructose transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0015755 fructose transmembrane transport;GO:0008645 hexose transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 5.1,
        "record_id": "Q6PXP3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6UWM5-1",
        "uniprot_id": "GPRL1_HUMAN",
        "mass": 27151.0,
        "length": 242,
        "protein_name": "GLIPR1-like protein 1",
        "gene_name": "GLIPR1L1",
        "organism": "Human",
        "refseq_name": "GLIPR1-like protein 1 isoform 1 precursor",
        "refseq_ac": "NP_001291893",
        "gene_names_uniprotkb": "GLIPR1L1; PRO7434",
        "gene_names_refseq": "ALKN2972; GLIPR1L1; PRO7434",
        "protein_names_uniprotkb": "GLIPR1-like protein 1",
        "protein_names_refseq": "GLI pathogenesis related 1 like 1; GLIPR1-like protein 1 isoform 1 precursor; GLIPR1-like protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:256710)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "12975309;15340161;16714093;36215666",
        "class_list": "",
        "function": "Required for optimal fertilization at the stage of sperm-oocyte fusion, plays a role in optimizing acrosome function, the translocation of IZUMO1 during the acrosome reaction and the fertilization process. Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation. Also component of the CD9-positive microvesicules found in the cauda region., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96L06",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0001669 acrosomal vesicle;GO:0098635 protein complex involved in cell-cell adhesion",
        "go_biological_process": "GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q6UWM5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z4T8-1",
        "uniprot_id": "GLTL5_HUMAN",
        "mass": 51427.0,
        "length": 443,
        "protein_name": "Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5",
        "gene_name": "GALNTL5",
        "organism": "Human",
        "refseq_name": "inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5",
        "refseq_ac": "NP_660335",
        "gene_names_uniprotkb": "GALNTL5; GALNT15",
        "gene_names_refseq": "GALNACT19; GALNT15; GALNTL5; GalNAc-T5L",
        "protein_names_uniprotkb": "Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5; GalNAc-T15; Polypeptide GalNAc transferase 15; Protein-UDP acetylgalactosaminyltransferase 15; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 15; pp-GaNTase 15",
        "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 15; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5; galNAc-T15; inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5; polypeptide GalNAc transferase 15; polypeptide GalNAc transferase-like 5; pp-GaNTase 15; protein-UDP acetylgalactosaminyltransferase 15; putative polypeptide N-acetylgalactosaminyltransferase-like protein 5; testis tissue sperm-binding protein Li 61n",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:168391);  (R-HSA-913709)",
        "pathway_count": 2,
        "publication_count": 28,
        "publication_id_list": "10330415;10430883;10753916;11042166;11237011;11283017;11304796;11821425;12855678;1329093;15486459;15560372;15620693;17113861;18537974;22183981;24398516;24643043;28206990;30628500;35580925;7655172;9295285;9394011;9417100;9435216;9915862;9988682",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Mutation of GALNTL5 gene identified in patients diagnosed with asthenozoospermia., [RefSeq, PubMed]; Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 624,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q75KN2;Q75MD3;Q8NCV4;Q8WW05;Q9UDR9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0016740 transferase activity",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031902 late endosome membrane",
        "go_biological_process": "GO:0007286 spermatid development",
        "synthesized_glycan_count": 7434,
        "hit_score": 2.9,
        "record_id": "Q7Z4T8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N3T1-1",
        "uniprot_id": "GLT15_HUMAN",
        "mass": 73063.0,
        "length": 639,
        "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 15",
        "gene_name": "GALNT15",
        "organism": "Human",
        "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 15 isoform 1",
        "refseq_ac": "NP_473451",
        "gene_names_uniprotkb": "GALNT15; GALNTL2; PRO1564",
        "gene_names_refseq": "GALNACT15; GALNT15; GALNTL2; PIH5; pp-GalNAc-T15",
        "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 15; 2.4.1.41; GalNAc-T-like protein 2; Polypeptide GalNAc transferase-like protein 2; Polypeptide N-acetylgalactosaminyltransferase-like protein 2; Protein-UDP acetylgalactosaminyltransferase-like protein 2; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2; pp-GaNTase-like protein 2",
        "protein_names_refseq": "UDP-GalNAc transferase T15; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2; galNAc-T-like protein 2; polypeptide GalNAc transferase 15; polypeptide GalNAc transferase-like protein 2; polypeptide N-acetylgalactosaminyltransferase 15 isoform 1; polypeptide N-acetylgalactosaminyltransferase-like protein 2; pp-GaNTase-like protein 2; pregnancy-induced hypertension syndrome-related protein 5; protein-UDP acetylgalactosaminyltransferase-like protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:117248);  (R-HSA-913709)",
        "pathway_count": 2,
        "publication_count": 36,
        "publication_id_list": "10330415;10430883;10753916;11042166;11237011;11256614;11283017;11304796;11597177;11821425;12855678;12975309;1329093;14702039;15147861;15486459;15489334;15560372;15620693;16641997;17113861;17974005;18537974;20800603;22183981;24643043;32296183;33592498;35051231;7655172;9295285;9394011;9417100;9435216;9915862;9988682",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 908,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NMN1;B2R638;F1LIP6;Q86T60;Q96C46;Q96DJ5",
        "ec_number_list": "2.4.1.41;2.4.1.-",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0030133 transport vesicle",
        "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine",
        "synthesized_glycan_count": 7434,
        "hit_score": 3.7,
        "record_id": "Q8N3T1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TBA6-1",
        "uniprot_id": "GOGA5_HUMAN",
        "mass": 83024.0,
        "length": 731,
        "protein_name": "Golgin subfamily A member 5",
        "gene_name": "GOLGA5",
        "organism": "Human",
        "refseq_name": "golgin subfamily A member 5 isoform X2",
        "refseq_ac": "XP_011535722",
        "gene_names_uniprotkb": "GOLGA5; PIG31; RETII; RFG5",
        "gene_names_refseq": "GOLGA5; GOLIM5; RFG5; ret-II",
        "protein_names_uniprotkb": "Golgin subfamily A member 5; Cell proliferation-inducing gene 31 protein; Golgin-84; Protein Ret-II; RET-fused gene 5 protein",
        "protein_names_refseq": "golgin subfamily A member 5 isoform X2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9950);  (R-HSA-6811438)",
        "pathway_count": 2,
        "publication_count": 113,
        "publication_id_list": "10189370;10652308;10652516;11237011;11718716;11748249;12011112;12383348;12429822;12538640;15144186;15504911;15592455;15718469;15728195;15758030;17081983;17274799;18086915;18256213;18451304;18669648;19164740;19536132;19715559;20163571;20874812;21406692;21807881;21872626;21993680;22013193;22188167;22223895;23091056;23239882;23378023;23462996;23481700;23839779;23936529;23940353;24119662;24275569;24714562;24715725;25576301;25645385;25708460;26154972;26375851;26728094;26992070;2734021;27846572;27920218;28063628;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30429286;30524438;30833945;31154438;31844290;31848261;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33392160;33592498;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34405274;34509645;34561969;35051231;35580925;36010968;36284347;39302247;8636227;8945478;9244307;9443391;9476900;9510256;9653114;9707577;9915833",
        "class_list": "",
        "function": "Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JRU1;O95287;Q03962;Q2TS49;Q9UQQ7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042803 protein homodimerization activity;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0030133 transport vesicle;GO:0005801 cis-Golgi network",
        "go_biological_process": "GO:0007030 Golgi organization;GO:0048193 Golgi vesicle transport;GO:0000301 retrograde transport, vesicle recycling within Golgi",
        "synthesized_glycan_count": 0,
        "hit_score": 11.6,
        "record_id": "Q8TBA6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TDQ7-1",
        "uniprot_id": "GNPI2_HUMAN",
        "mass": 31085.0,
        "length": 276,
        "protein_name": "Glucosamine-6-phosphate deaminase 2",
        "gene_name": "GNPDA2",
        "organism": "Human",
        "refseq_name": "glucosamine-6-phosphate deaminase 2 isoform 2",
        "refseq_ac": "NP_001257809",
        "gene_names_uniprotkb": "GNPDA2; GNP2",
        "gene_names_refseq": "GNP2; GNPDA2; SB52",
        "protein_names_uniprotkb": "Glucosamine-6-phosphate deaminase 2; 3.5.99.6; GlcN6P deaminase 2; Glucosamine-6-phosphate isomerase 2; Glucosamine-6-phosphate isomerase SB52",
        "protein_names_refseq": "glcN6P deaminase 2; glucosamine-6-phosphate deaminase 2 isoform 2; glucosamine-6-phosphate isomerase 2; glucosamine-6-phosphate isomerase SB52",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:132789);  (R-HSA-70171)",
        "pathway_count": 2,
        "publication_count": 93,
        "publication_id_list": "10714828;11237011;11371164;11506403;11780755;12616532;1278465;12965206;13538944;15710582;16511037;17804405;183598;1871135;18910716;18910717;18927083;19079261;19164386;19746409;22219026;23168256;23446454;23481700;2462567;25502872;25645385;25648650;25892735;26887390;26992070;2793178;28218747;28228285;28446606;2846554;28514659;28834231;28904123;29242379;29493099;2960695;29769354;29786170;30315122;30517626;31092671;31154438;3170585;31844290;3208766;32157095;32161166;32350084;32357974;32938616;33298915;3355497;33633747;33691108;33912179;33968037;34357683;3453121;34782236;34932366;35051231;3529090;36284347;36580660;37938771;4413246;4555506;4827367;5009693;5687724;6434534;6444721;6451249;6696436;6771269;7144574;7150652;7391027;7717389;7825568;7989588;8117307;8325892;8447317;8786021;9438414;9493266",
        "class_list": "glycogene",
        "function": "Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling., [UniProtKB, PubMed, PubMed]; GNPDA1 siRNA induced GFAT2 which was hardly measurable in these cells under standard culture conditions, GNPDA2 siRNA increased GFAT1, and GFAT1 siRNA increased the expression of hyaluronan synthase 2 (HAS2). Silencing of GFAT1 stimulated GNPDA1 and GDPDA2, and inhibited cell migration., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing body mass index and susceptibility to obesity. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 286,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DJF3;Q2VYF1;Q59EA7;Q8NCZ8;Q96BJ4;Q96NC6",
        "ec_number_list": "3.5.99.6",
        "go_molecular_function": "GO:0004342 glucosamine-6-phosphate deaminase activity;GO:0042802 identical protein binding;GO:0016853 isomerase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006043 glucosamine catabolic process;GO:0006046 N-acetylglucosamine catabolic process;GO:0005975 carbohydrate metabolic process;GO:0006048 UDP-N-acetylglucosamine biosynthetic process;GO:0019262 N-acetylneuraminate catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.6,
        "record_id": "Q8TDQ7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TDT2-1",
        "uniprot_id": "GP152_HUMAN",
        "mass": 50962.0,
        "length": 470,
        "protein_name": "Probable G protein-coupled receptor 152",
        "gene_name": "GPR152",
        "organism": "Human",
        "refseq_name": "probable G-protein coupled receptor 152",
        "refseq_ac": "NP_996880",
        "gene_names_uniprotkb": "GPR152; PGR5",
        "gene_names_refseq": "GPR152; PGR5",
        "protein_names_uniprotkb": "Probable G protein-coupled receptor 152; G protein-coupled receptor PGR5",
        "protein_names_refseq": "G protein-coupled receptor PGR5; probable G-protein coupled receptor 152",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:390212)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "12044878;12679517;23481700;30779550;31222486",
        "class_list": "",
        "function": "Orphan receptor., [UniProtKB]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 4,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q0VD88;Q86SM0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q8TDT2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96CP6-1",
        "uniprot_id": "ASTRA_HUMAN",
        "mass": 80680.0,
        "length": 724,
        "protein_name": "Protein Aster-A",
        "gene_name": "GRAMD1A",
        "organism": "Human",
        "refseq_name": "protein Aster-A isoform 2",
        "refseq_ac": "NP_001129671",
        "gene_names_uniprotkb": "GRAMD1A; KIAA1533",
        "gene_names_refseq": "GRAMD1A; KIAA1533; LAMa",
        "protein_names_uniprotkb": "Protein Aster-A; GRAM domain-containing protein 1A",
        "protein_names_refseq": "GRAM domain-containing protein 1A; protein Aster-A isoform 2; protein Aster-A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57655)",
        "pathway_count": 1,
        "publication_count": 59,
        "publication_id_list": "11237011;16303743;17081983;18669648;19651622;19690332;20112406;21406692;22544926;22645359;23186163;23481700;24715725;25418920;25576301;26375851;26811146;26992070;27585821;27600516;27846572;27920218;28063628;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29469807;29493099;29557506;29632046;29786170;30429286;30484775;30620550;31222192;31844290;32157095;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33633747;33912179;33968037;34509645;34932366;35051231;35580925;35860689;36010968;37938771",
        "class_list": "",
        "function": "Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192)., [UniProtKB, UniProtKB, PubMed]; GRAMD1A Is a Biomarker of Kidney Renal Clear Cell Carcinoma and Is Associated with Immune Infiltration in the Tumour Microenvironment. Publication Status: Online-Only, [RefSeq, PubMed]; GRAMD2a, but not GRAMD1a, co-localizes with the E-Syt2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol phosphate lipid-dependent manner. Data from an analysis of cells lacking GRAMD2a suggest that it is an organizer of the membrane contact sites with pleiotropic functions including calcium homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; STAT5 was the target of GRAMD1A; GRAMD1A regulated the target genes of STAT5 and the transcriptional activity of STAT5. Inhibition of STAT5 in indicated HCC cells overexpressing GRAMD1A suppressed the effects of GRAMD1A on the self-renewal of HCC stem cell, resistance to chemotherapy and tumor growth, suggesting GRAMD1A promoted the self-renewal of HCC stem cells and the development of HCC by increasing STAT5 level. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NKY7;Q8NC77;Q9P1Z5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0015485 cholesterol binding;GO:0120020 cholesterol transfer activity;GO:0008289 lipid binding",
        "go_cellular_component": "GO:0044232 organelle membrane contact site;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome",
        "go_biological_process": "GO:0032366 intracellular sterol transport;GO:0071397 cellular response to cholesterol;GO:0006914 autophagy",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "Q96CP6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H772-1",
        "uniprot_id": "GREM2_HUMAN",
        "mass": 19320.0,
        "length": 168,
        "protein_name": "Gremlin-2",
        "gene_name": "GREM2",
        "organism": "Human",
        "refseq_name": "gremlin-2 precursor",
        "refseq_ac": "NP_071914",
        "gene_names_uniprotkb": "GREM2; CKTSF1B2; DAND3; PRDC",
        "gene_names_refseq": "CKTSF1B2; DAND3; GREM2; PRDC; STHAG9",
        "protein_names_uniprotkb": "Gremlin-2; Cysteine knot superfamily 1, BMP antagonist 2; DAN domain family member 3; Protein related to DAN and cerberus",
        "protein_names_refseq": "DAN domain family member 3; cysteine knot superfamily 1, BMP antagonist 2; gremlin 2, cysteine knot superfamily, homolog; gremlin-2 precursor; gremlin-2; protein related to DAN and cerberus",
        "tax_id": 9606,
        "disease": "tooth agenesis (Disease Ontology:DOID:0050591); tooth agenesis, selective, 9 (MONDO:MONDO:0014999)",
        "pathway": " (hsa:64388);  (R-HSA-201451)",
        "pathway_count": 2,
        "publication_count": 35,
        "publication_id_list": "10458166;10587654;10712517;11016919;11121043;11158580;11278251;11509558;11571290;11714695;11779505;12151385;12519765;12592392;12821673;12857866;15254711;16672363;17029022;17068149;17311849;17356069;26416033;32297643;33144675;33369218;35349825;35619575;7644468;7791754;8119126;8653785;8893010;9136927;9436979",
        "class_list": "",
        "function": "Association of Gremlin-2 gene polymorphisms with osteoporosis risk in Chinese postmenopausal women., [RefSeq, PubMed]; Cancer-associated fibroblast-secreted exosomal miR-423-5p promotes chemotherapy resistance in prostate cancer by targeting GREM2 through the TGF-beta signaling pathway., [RefSeq, PubMed]; Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells., [UniProtKB, UniProtKB]; Functional characterization of ATF1, GREM2 AND WNT10B variants associated with tooth agenesis., [RefSeq, PubMed]; GREM2 is associated with human central obesity and inhibits visceral preadipocyte browning., [RefSeq, PubMed]; MiR-103a-3p Contributes to the Progression of Colorectal Cancer by Regulating GREM2 Expression., [RefSeq, PubMed]; This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86UD9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity;GO:0036122 BMP binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0010172 embryonic body morphogenesis;GO:0038098 sequestering of BMP from receptor via BMP binding;GO:0060300 regulation of cytokine activity;GO:0019221 cytokine-mediated signaling pathway;GO:0048263 determination of dorsal identity",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "Q9H772-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NS18-1",
        "uniprot_id": "GLRX2_HUMAN",
        "mass": 18052.0,
        "length": 164,
        "protein_name": "Glutaredoxin-2, mitochondrial",
        "gene_name": "GLRX2",
        "organism": "Human",
        "refseq_name": "glutaredoxin 2 isoform 3",
        "refseq_ac": "NP_001230328",
        "gene_names_uniprotkb": "GLRX2; CGI-133; GRX2",
        "gene_names_refseq": "CGI-133; GLRX2; GRX2",
        "protein_names_uniprotkb": "Glutaredoxin-2, mitochondrial",
        "protein_names_refseq": "bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2); glutaredoxin 2 isoform 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51022)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "10.1101/2023.09.13.557529;11297543;11397793;14676218;15184054;15297967;15328416;15649413;15917333;17121859;17961515;23186163;25576301;28228285;28904123;29242379;29493099;31844290;32357974;32938616;34405274;38256132;39894887",
        "class_list": "",
        "function": "Glutaredoxin 2 Protein (Grx2) as an Independent Prognostic Factor Associated with the Survival of Colon Adenocarcinoma Patients. Publication Status: Online-Only, [RefSeq, PubMed]; Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Grx2 is constitutively expressed in both neuron and glia in mouse and human brain including the neurons in human substantia nigra., [RefSeq, PubMed]; Results suggest an important role for glutaredoxin 2 in protection and recovery from oxidative stress, [RefSeq, PubMed]; The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression. [provided by RefSeq, Aug 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3LR69;Q7L1N7;Q96JC0;Q9Y3D4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008794 arsenate reductase (glutaredoxin) activity;GO:0015038 glutathione disulfide oxidoreductase activity;GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion",
        "go_biological_process": "GO:0030154 cell differentiation;GO:0051775 response to redox state;GO:0006355 regulation of DNA-templated transcription;GO:0006915 apoptotic process;GO:0009266 response to temperature stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q9NS18-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NVN8-1",
        "uniprot_id": "GNL3L_HUMAN",
        "mass": 65573.0,
        "length": 582,
        "protein_name": "Guanine nucleotide-binding protein-like 3-like protein",
        "gene_name": "GNL3L",
        "organism": "Human",
        "refseq_name": "guanine nucleotide-binding protein-like 3-like protein",
        "refseq_ac": "NP_001171748",
        "gene_names_uniprotkb": "GNL3L",
        "gene_names_refseq": "GNL3B; GNL3L",
        "protein_names_uniprotkb": "Guanine nucleotide-binding protein-like 3-like protein",
        "protein_names_refseq": "G protein nucleolar 3B; guanine nucleotide binding protein-like 3 (nucleolar)-like; guanine nucleotide-binding protein-like 3-like protein; novel GTPase",
        "tax_id": 9606,
        "disease": "obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:54552)",
        "pathway_count": 1,
        "publication_count": 101,
        "publication_id_list": "11237011;16251348;17034816;18691976;18991276;19487455;20068231;21063916;21132010;22645359;22869377;23481700;24714562;24715725;25114211;25418920;25469497;25576301;25645385;25802875;25880248;26154972;26374642;26375851;26992070;27600516;27846572;27920218;28063628;28218747;28228285;28446606;28514659;28832583;28834231;28904123;29242379;29331515;29371260;29393594;29437277;29493099;29508533;29557506;29632046;29769354;29786170;29789417;30192525;30315122;30410026;30418433;30429286;30484775;30524438;30779550;30833945;31092671;31154438;31217245;31530632;31844290;31848261;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33298915;33392160;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34032716;34087483;34171305;34185709;34509645;34932366;35051231;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37938771;38022822;38148364",
        "class_list": "",
        "function": "Analysis uncovers an important role for Grn1p/GNL3L within this unique group of nucleolar GTPases, [RefSeq, PubMed]; Differences in the relative nucleostemin protein and mRNA levels may reflect the degree of proliferation of mesnchymal stem cells and can be used to characterize in vitro expansion capabilities, [RefSeq, PubMed]; GNL3L is composed of distinct modules, each of which plays a specific role in molecular interactions for its nucleolar retention and subsequent function(s) within the nucleolus, [RefSeq, PubMed]; GNL3L promotes autophagy via regulating AMPK signaling in esophageal cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; High expression of guanine nucleotide-binding protein-like-3-like is associated with poor prognosis in esophageal cancer., [RefSeq, PubMed]; Knockdown of GNL3L Alleviates the Progression of COPD Through Inhibiting the ATM/p53 Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005525 GTP binding",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0016020 membrane;GO:0005697 telomerase holoenzyme complex",
        "go_biological_process": "GO:1904816 positive regulation of protein localization to chromosome, telomeric region;GO:0031334 positive regulation of protein-containing complex assembly;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0042254 ribosome biogenesis;GO:0031647 regulation of protein stability",
        "synthesized_glycan_count": 0,
        "hit_score": 10.4,
        "record_id": "Q9NVN8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NW75-1",
        "uniprot_id": "GPTC2_HUMAN",
        "mass": 58944.0,
        "length": 528,
        "protein_name": "G patch domain-containing protein 2",
        "gene_name": "GPATCH2",
        "organism": "Human",
        "refseq_name": "G patch domain-containing protein 2 isoform 2",
        "refseq_ac": "NP_001284683",
        "gene_names_uniprotkb": "GPATCH2; GPATC2",
        "gene_names_refseq": "CT110; GPATC2; GPATCH2; PPP1R30; Pfa1",
        "protein_names_uniprotkb": "G patch domain-containing protein 2",
        "protein_names_refseq": "G patch domain-containing protein 2 isoform 2; G patch domain-containing protein 2; cancer/testis antigen 110; protein phosphatase 1, regulatory subunit 30",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55105)",
        "pathway_count": 1,
        "publication_count": 30,
        "publication_id_list": "10.1101/2023.09.13.557529;17081983;18669648;18767875;19432882;19651622;19690332;20068231;21406692;23186163;24715725;25376275;25576301;26992070;27846572;28832583;28904123;29242379;31154438;31844290;31848261;32387766;32938616;33141586;33298915;33968037;34087483;35051231;36284347;37340703",
        "class_list": "",
        "function": "Enhances the ATPase activity of DHX15 in vitro., [UniProtKB, PubMed]; GPATC2 may be involved in inhibiting G1-S phase transition in 293T cells., [RefSeq, PubMed]; Involvement of GPATCH2 overexpression in breast carcinogensis is reported., [RefSeq, PubMed]; The gene encodes a nuclear factor that may play a role in spermatogenesis and in tumor growth during breast cancer. The encoded protein contains a G-patch domain with an RNA binding motif. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VYK7;Q5VYK8;Q86YE7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003676 nucleic acid binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0016607 nuclear speck",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q9NW75-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UBQ7-1",
        "uniprot_id": "GRHPR_HUMAN",
        "mass": 35668.0,
        "length": 328,
        "protein_name": "Glyoxylate reductase/hydroxypyruvate reductase",
        "gene_name": "GRHPR",
        "organism": "Human",
        "refseq_name": "glyoxylate reductase/hydroxypyruvate reductase",
        "refseq_ac": "NP_036335",
        "gene_names_uniprotkb": "GRHPR; GLXR; MSTP035",
        "gene_names_refseq": "GLXR; GLYD; GRHPR; PH2",
        "protein_names_uniprotkb": "Glyoxylate reductase/hydroxypyruvate reductase; 1.1.1.79; 1.1.1.81",
        "protein_names_refseq": "epididymis secretory sperm binding protein; glycerate-2-dehydrogenase; glyoxylate reductase and hydroxypyruvate reductase; glyoxylate reductase/hydroxypyruvate reductase",
        "tax_id": 9606,
        "disease": "primary hyperoxaluria type 2 (Disease Ontology:DOID:0111671); primary hyperoxaluria (Disease Ontology:DOID:2977)",
        "pathway": " (hsa:9380);  (R-HSA-389661)",
        "pathway_count": 2,
        "publication_count": 134,
        "publication_id_list": "10484776;10524214;10679197;10777549;10978532;11237011;12865426;12899834;13681368;13681370;14170323;15118850;15275975;15340920;15802217;1601857;16616139;16756993;1703535;17074750;17088322;17669354;18160138;18215067;18802091;19352492;20018850;20112406;20166139;20603179;2158891;21998747;22516612;23481700;23599041;2363689;23783831;24116921;24275569;24366607;24715725;25418920;25469497;25576301;25645385;25697095;25747990;26154972;26768311;26811146;26858947;26992070;27600516;27846572;27862975;27893789;27920218;28063628;28228285;28467828;28832583;28834231;28860189;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30429286;30524438;30573663;30779550;31154438;31222486;31530632;31717259;31844290;31848261;31937595;31998317;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33691108;33717175;33968037;33981976;34019948;34087483;3416563;34171305;34211107;34229054;34289161;34357683;34405274;34509645;34561969;34932366;35051231;35561310;35580925;36010968;36215666;36240223;36241641;36284347;36581221;37938771;38200664;38665916;40596516;40914422;500817;6250440;9163533;9820813",
        "class_list": "",
        "function": "Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate, oxidizes D-glycerate to hydroxypyruvate., [UniProtKB, PubMed, PubMed]; GRHPR directly interacts with SVCT1., [RefSeq, PubMed]; GRHPR was genotyped in Japanese patients with PH2 and all GRHPR mutations described to date were reviewed in terms of geographic and ethnic association, [RefSeq, PubMed]; Glyoxylate reductase/hydroxypyruvate reductase regulates the free d-aspartate level in mammalian cells., [RefSeq, PubMed]; Glyoxylate reductase: Definitive identification in human liver mitochondria, its importance for the compartment-specific detoxification of glyoxylate., [RefSeq, PubMed]; This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T945;Q9H3E9;Q9H636;Q9UKX1",
        "ec_number_list": "1.1.1.79;1.1.1.81",
        "go_molecular_function": "GO:0008465 hydroxypyruvate reductase (NADH) activity;GO:0016618 hydroxypyruvate reductase [NAD(P)H] activity;GO:0030267 glyoxylate reductase (NADPH) activity;GO:0042803 protein homodimerization activity;GO:0051287 NAD binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005782 peroxisomal matrix;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0043648 dicarboxylic acid metabolic process;GO:0046487 glyoxylate metabolic process;GO:0019752 carboxylic acid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 13.7,
        "record_id": "Q9UBQ7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y2T3-1",
        "uniprot_id": "GUAD_HUMAN",
        "mass": 51003.0,
        "length": 454,
        "protein_name": "Guanine deaminase",
        "gene_name": "GDA",
        "organism": "Human",
        "refseq_name": "guanine deaminase isoform a",
        "refseq_ac": "NP_001229434",
        "gene_names_uniprotkb": "GDA; KIAA1258",
        "gene_names_refseq": "CYPIN; GAH; GDA; GUANASE; NEDASIN",
        "protein_names_uniprotkb": "Guanine deaminase; 3.5.4.3; GAH; Guanase; Guanine aminase; Guanine aminohydrolase; p51-nedasin",
        "protein_names_refseq": "cytoplasmic PSD-95 interactor; cytoplasmic PSD95 interactor; guanine aminase; guanine aminohydrolase; guanine deaminase isoform a; p51-nedasin",
        "tax_id": 9606,
        "disease": "stomach cancer (Disease Ontology:DOID:10534)",
        "pathway": " (hsa:9615);  (R-HSA-74259)",
        "pathway_count": 2,
        "publication_count": 52,
        "publication_id_list": "10.1101/2023.09.13.557529;10075721;10364222;10542258;10681516;10766785;11083867;11133996;11237011;11278832;11690631;12750059;12947102;1637327;17234634;17301077;17405878;19470646;20081199;2104852;2129526;2157703;22662200;23203137;2344353;24260472;25108359;25576301;2848805;28832583;29242379;29393594;29557506;3029074;3036115;30379171;31844290;32215662;32350084;32517074;33537174;33592498;33981976;34185709;35051231;36215666;36241641;36284347;36943641;39534244;6771276;8670112",
        "class_list": "",
        "function": "Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia., [UniProtKB, PubMed, PubMed]; Guanine Deaminase Stimulates Ultraviolet-induced Keratinocyte Senescence in Seborrhoeic Keratosis via Guanine Metabolites. Publication Status: Online-Only, [RefSeq, PubMed]; Guanine Deaminase in Human Epidermal Keratinocytes Contributes to Skin Pigmentation. Publication Status: Online-Only, [RefSeq, PubMed]; Long Non-Coding RNA-GDA-1 Promotes Keratinocyte Proliferation and Psoriasis Inflammation by Regulating the STAT3/NF-kappaB Signaling Pathway via Forkhead Box M1., [RefSeq, PubMed]; This gene encodes an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DTY5;Q5SZC7;Q9H335;Q9ULG2",
        "ec_number_list": "3.5.4.3",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008892 guanine deaminase activity;GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0046098 guanine metabolic process;GO:0007399 nervous system development;GO:0006139 nucleobase-containing compound metabolic process;GO:0006147 guanine catabolic process;GO:0006161 deoxyguanosine catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.8,
        "record_id": "Q9Y2T3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y5Y3-1",
        "uniprot_id": "GPR45_HUMAN",
        "mass": 41967.0,
        "length": 372,
        "protein_name": "Probable G protein-coupled receptor 45",
        "gene_name": "GPR45",
        "organism": "Human",
        "refseq_name": "probable G-protein coupled receptor 45",
        "refseq_ac": "NP_009158",
        "gene_names_uniprotkb": "GPR45",
        "gene_names_refseq": "GPR45; PSP24(ALPHA); PSP24-1; PSP24-alpha; PSP24A; PSP24",
        "protein_names_uniprotkb": "Probable G protein-coupled receptor 45",
        "protein_names_refseq": "high-affinity lysophosphatidic acid receptor; probable G-protein coupled receptor 45",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11250);  (R-HSA-418555)",
        "pathway_count": 2,
        "publication_count": 55,
        "publication_id_list": "10036181;11007482;12036966;12058044;12106601;12180353;12860470;13549488;14671004;1517224;15765929;15769620;15951850;16313925;16687412;16923326;16959974;17168849;18044684;18577758;19105585;19876791;19929708;20381629;21036126;2163110;2417744;24687066;2491850;2553411;2553705;26417854;2871555;29443750;29602314;30833991;3127824;31279028;31399091;31983287;32226383;32497535;32540603;32618402;32715661;33049737;33392160;35051231;6085243;8340388;8514797;8672451;9263355;9417641;9651336",
        "class_list": "",
        "function": "Protein carrier that acts as a regulator of food intake in the paraventricular nucleus of the hypothalamus (PVH) by mediating transport of G(s) into primary cilia (By similarity). Transported into primary cilia of PVH neurons via its association with TULP3 and carries G(s) into the primary cilia to support MC4R activity and activate ADCY3, leading to cAMP production, which signals to suppress appetite (By similarity). Does not act as a canonical G protein-coupled receptor: does not promote the exchange of GDP for GTP on G(s) protein but mediates G(s) translocation into primary cilia (By similarity)., [UniProtKB, UniProtKB]; This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6NWS4;Q6NXU6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0140597 protein carrier chaperone",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0060170 ciliary membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0097499 protein localization to non-motile cilium;GO:0032099 negative regulation of appetite",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "Q9Y5Y3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y692-1",
        "uniprot_id": "GMEB1_HUMAN",
        "mass": 62591.0,
        "length": 573,
        "protein_name": "Glucocorticoid modulatory element-binding protein 1",
        "gene_name": "GMEB1",
        "organism": "Human",
        "refseq_name": "glucocorticoid modulatory element-binding protein 1 isoform 2",
        "refseq_ac": "NP_001306603",
        "gene_names_uniprotkb": "GMEB1",
        "gene_names_refseq": "GMEB1; P96PIF; PIF96",
        "protein_names_uniprotkb": "Glucocorticoid modulatory element-binding protein 1; DNA-binding protein p96PIF; GMEB-1; PIF p96; Parvovirus initiation factor p96",
        "protein_names_refseq": "DNA-binding protein p96PIF; PIF p96; glucocorticoid modulatory element-binding protein 1 isoform 2; parvovirus initiation factor p96",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10691)",
        "pathway_count": 1,
        "publication_count": 77,
        "publication_id_list": "10386584;10523663;10894151;12702733;22424782;23481700;24715725;25645385;25892735;26154972;26992070;27543614;27600516;27862975;28228285;28514659;28657654;28832583;28834231;28904123;29242379;29351928;29485866;29493099;29508533;29557506;29632711;29769354;29786170;30059200;30315122;30379171;30429286;30524438;31046799;31154438;31222486;31373491;31492838;31844290;31848261;31998317;32157095;32357974;32387766;32488085;32502341;32514408;32574038;32897882;32938616;32983136;33141586;33298915;33592498;33691108;33912179;33968037;33981976;34019948;34087483;34211107;34405274;34509645;34846842;35051231;35132862;35138101;35254053;35289036;35561310;35580925;36010968;36241641;38665916;39531497;40307207",
        "class_list": "",
        "function": "Acts as a DNA-binding transcriptional regulator involved in modulating the expression of genes responsive to glucocorticoid signaling (PubMed:12702733). Specifically binds AT-rich DNA motifs known as glucocorticoid modulatory elements (GMEs), repressing or enhancing transcription depending on cellular context (PubMed:10894151). Forms heterodimeric complexes with GMEB2, which enhances its DNA-binding specificity and transcriptional activity. This complex plays a critical role in the repression of glucocorticoid receptor (GR/NR3C1) transcriptional activity, acting as a negative modulator of glucocorticoid signaling (PubMed:10894151). Regulates dopamine-enriched midbrain genes, including tyrosine hydroxylase/TH and the dopamine transporter SLC6A3, essential for dopamine signaling (By similarity). Also binds the transferrin receptor promoter. In the cytoplasm, inhibits caspase activation and neuronal apoptosis by stabilizing CFLARL and blocking pro-caspase 8 activation (PubMed:31046799, PubMed:32514408)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Our findings show the de-ubiquitinase USP40 regulates the ubiquitination and degradation of CFLARL; and GMEB1 acts as a bridge protein for USP40 and CFLARL. Mechanistically, we found GMEB1 inhibits the activation of CASP8 by modulating ubiquitination and degradation of CFLARL Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 13,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 13,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 13,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 13,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AT48;Q9NWH1;Q9UKD0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043066 negative regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.3,
        "record_id": "Q9Y692-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A0A0MS14-1",
        "uniprot_id": "HV145_HUMAN",
        "mass": 13508.0,
        "length": 117,
        "protein_name": "Immunoglobulin heavy variable 1-45",
        "gene_name": "IGHV1-45",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "IGHV1-45",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 1-45",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "11340299;17576170;20176268;22158414;24600447",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 259,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A0A0A0MS14-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96LU5-1",
        "uniprot_id": "IMP1L_HUMAN",
        "mass": 18504.0,
        "length": 166,
        "protein_name": "Mitochondrial inner membrane protease subunit 1",
        "gene_name": "IMMP1L",
        "organism": "Human",
        "refseq_name": "mitochondrial inner membrane protease subunit 1",
        "refseq_ac": "NP_001291203",
        "gene_names_uniprotkb": "IMMP1L",
        "gene_names_refseq": "IMMP1L; IMMP1; IMP1-LIKE; IMP1",
        "protein_names_uniprotkb": "Mitochondrial inner membrane protease subunit 1; 3.4.21.-; IMP1-like protein",
        "protein_names_refseq": "IMP1 inner mitochondrial membrane peptidase-like; mitochondrial inner membrane protease subunit 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:196294)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;15814844;19913121;20628086;23481700;30315122;31530632;31848261;32938616;33912179;33968037",
        "class_list": "",
        "function": "Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The mitochondrial inner membrane peptidase (IMP) complex generates mature, active proteins in the mitochondrial intermembrane space by proteolytically removing the mitochondrial targeting presequence of nuclear-encoded proteins. IMP1 and IMP2 (IMMP2L; MIM 605977) are the catalytic subunits of the IMP complex (Burri et al., 2005 [PubMed 15814844]).[supplied by OMIM, Sep 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DQZ7;Q96SH9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity",
        "go_cellular_component": "GO:0042720 mitochondrial inner membrane peptidase complex;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane",
        "go_biological_process": "GO:0006627 protein processing involved in protein targeting to mitochondrion;GO:0006465 signal peptide processing",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q96LU5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A0C4DH29-1",
        "uniprot_id": "HV103_HUMAN",
        "mass": 13008.0,
        "length": 117,
        "protein_name": "Immunoglobulin heavy variable 1-3",
        "gene_name": "IGHV1-3",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "IGHV1-3",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 1-3",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "11340299;17576170;20176268;22158414;24600447",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 520,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A0A0C4DH29-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A0C4DH33-1",
        "uniprot_id": "HV124_HUMAN",
        "mass": 12824.0,
        "length": 117,
        "protein_name": "Immunoglobulin heavy variable 1-24",
        "gene_name": "IGHV1-24",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "IGHV1-24",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 1-24",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "11340299;17576170;20176268;22158414;24600447;32502341",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 460,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "A0A0C4DH33-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A0C4DH41-1",
        "uniprot_id": "HV461_HUMAN",
        "mass": 13066.0,
        "length": 118,
        "protein_name": "Immunoglobulin heavy variable 4-61",
        "gene_name": "IGHV4-61",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "IGHV4-61",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 4-61",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "11340299;17576170;20176268;22158414;24600447;30410026",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 370,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "A0A0C4DH41-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A0C4DH43-1",
        "uniprot_id": "HV70D_HUMAN",
        "mass": 13312.0,
        "length": 119,
        "protein_name": "Immunoglobulin heavy variable 2-70D",
        "gene_name": "IGHV2-70D",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "IGHV2-70D",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 2-70D",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 7,
        "publication_id_list": "11340299;17576170;20176268;22158414;24600447;32350084;32561536",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 591,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "A0A0C4DH43-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A0G2JMI3-1",
        "uniprot_id": "HV692_HUMAN",
        "mass": 12871.0,
        "length": 117,
        "protein_name": "Immunoglobulin heavy variable 1-69-2",
        "gene_name": "IGHV1-69-2",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "IGHV1-69-2",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 1-69-2",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "11340299;17576170;20176268;22158414;24600447",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 231,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A0A0G2JMI3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A0J9YX35-1",
        "uniprot_id": "HV64D_HUMAN",
        "mass": 12823.0,
        "length": 117,
        "protein_name": "Immunoglobulin heavy variable 3-64D",
        "gene_name": "IGHV3-64D",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "IGHV3-64D",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 3-64D",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "11340299;17576170;20176268;22158414;24600447",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 256,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A0A0J9YX35-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NYD6-1",
        "uniprot_id": "HXC10_HUMAN",
        "mass": 38073.0,
        "length": 342,
        "protein_name": "Homeobox protein Hox-C10",
        "gene_name": "HOXC10",
        "organism": "Human",
        "refseq_name": "homeobox protein Hox-C10",
        "refseq_ac": "NP_059105",
        "gene_names_uniprotkb": "HOXC10; HOX3I",
        "gene_names_refseq": "HOX3I; HOXC10",
        "protein_names_uniprotkb": "Homeobox protein Hox-C10; Homeobox protein Hox-3I",
        "protein_names_refseq": "homeo box C10; homeobox protein Hox-3I; homeobox protein Hox-C10; homeoprotein C10",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3226)",
        "pathway_count": 1,
        "publication_count": 34,
        "publication_id_list": "10835276;11237011;18491316;18669648;18691976;19651622;20068231;20112406;23186163;23301498;25218447;25772364;29393594;30059200;30379171;30620550;33592498;34087483;34846842;35051231;35254053;35289036;35513511;36010968;36264773;37217939;38063205;38154103;39152325;39191757;39302247;39531497;40596516;9357979",
        "class_list": "",
        "function": "HOXC10 indicates poor survival outcome in gastric cancer and promotes G1/S cell cycle transition through transcriptional repression of p21., [RefSeq, PubMed]; HOXC10 promotes hypertrophic scar fibroblast fibrosis through the regulation of STMN2 and the TGF-beta/Smad signaling pathway., [RefSeq, PubMed]; M[6]A-modified HOXC10 promotes HNSCC progression via co-activation of ADAM17/EGFR and Wnt/beta-catenin signaling., [RefSeq, PubMed]; Pan-cancer analysis of homeodomain-containing gene C10 and its carcinogenesis in lung adenocarcinoma., [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB, UniProtKB]; The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O15219;O15220;Q9BVD5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0120163 negative regulation of cold-induced thermogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q9NYD6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P29459-1",
        "uniprot_id": "IL12A_HUMAN",
        "mass": 24874.0,
        "length": 219,
        "protein_name": "Interleukin-12 subunit alpha",
        "gene_name": "IL12A",
        "organism": "Human",
        "refseq_name": "interleukin-12 subunit alpha isoform 1 precursor",
        "refseq_ac": "NP_000873",
        "gene_names_uniprotkb": "IL12A; NKSF1",
        "gene_names_refseq": "CLMF; IL-12A; IL12A; NFSK; NKSF1; P35",
        "protein_names_uniprotkb": "Interleukin-12 subunit alpha; CLMF p35; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL-12 subunit p35; IL-12A; NK cell stimulatory factor chain 1; NKSF1",
        "protein_names_refseq": "CLMF p35; IL-12, subunit p35; IL35 subunit; NF cell stimulatory factor chain 1; NK cell stimulatory factor chain 1; cytotoxic lymphocyte maturation factor 1, p35; cytotoxic lymphocyte maturation factor 35 kDa subunit; interleukin 12, p35; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin-12 alpha chain; interleukin-12 subunit alpha isoform 1 precursor; interleukin-12 subunit alpha",
        "tax_id": 9606,
        "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); hepatitis C (Disease Ontology:DOID:1883); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:3592);  (R-HSA-6783783);  (R-HSA-6785807);  (R-HSA-8984722);  (R-HSA-9020591)",
        "pathway_count": 5,
        "publication_count": 201,
        "publication_id_list": "10.1101/2023.09.13.557529;10023775;10092818;10219247;10369418;10415057;10415122;10433356;10510379;10586089;10867011;10899108;11054122;11058569;11084045;11104795;11120780;11237011;11278437;11278729;11356008;11404481;11463377;11960372;12121660;12223527;12242343;12554859;12600988;12626585;12829785;12832402;12893768;1347984;1374259;1460289;14634100;14712222;15004198;15087447;15116091;15261459;15584925;15720785;1578138;15805299;15869882;15919823;15950906;16007214;16048438;16107692;16205632;16236134;16324152;16397018;16451196;16510571;16540365;16548883;16606674;1673147;1674604;16982608;17427945;17458857;17572495;17874423;18033300;18243101;18353781;18389480;18447642;18644974;19124156;19185846;19397496;1940369;1940799;20054003;20145033;20493732;20691190;21102457;21252155;21689689;21730069;21937440;21994466;2204066;22046235;22205702;22306691;22383755;22487722;22693070;22814351;22851691;23086340;23124025;23172665;23455323;23481700;23555662;23967200;24058793;24097101;24572363;24743305;24743777;25234944;25259790;25645385;26154972;26279360;26375851;26972013;28228285;28904123;29557506;30115740;31217245;31844290;32357974;32502341;32938616;32983136;33141586;33298915;33592498;33968037;33981976;34211107;35051231;36010968;36241641;37938771;38203575;38243080;38278031;38690286;7510216;7512027;7512451;7516408;7527811;7528775;7529288;7543512;7593617;7594602;7638186;7684412;7687627;7795521;7796300;7898939;7902377;7907877;7911493;8063757;8085155;8102388;8120391;8163946;8186324;8301137;8537680;8602263;8605935;8621622;8662928;8663118;8668165;8734788;8742066;8797861;8816495;8871669;8897595;8910398;8921438;8943050;8946277;9013879;9013939;9312047;9342359;9354687;9449724;9498755;9550426;9651359;9723655;9736340;9794440;9822675;9836587;9874564;9890938;9918218",
        "class_list": "",
        "function": "Altered Gene Expression of IL-35 and IL-36alpha in the Skin of Patients with Atopic Dermatitis. Publication Status: Online-Only, [RefSeq, PubMed]; Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine (PubMed:8605935, PubMed:8943050). IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity (PubMed:1673147, PubMed:1674604, PubMed:8605935). Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits (PubMed:8943050). Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2 (PubMed:7528775). In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (PubMed:7638186). As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and also functions as an immune-suppressive cytokine (By similarity). Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers (PubMed:22306691). Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (PubMed:22306691)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites., [UniProtKB, UniProtKB, UniProtKB]; Signaling pathways underlying TGF-beta mediated suppression of IL-12A gene expression in monocytes., [RefSeq, PubMed]; The effects of IL-27 and IL-35 gene variation and expression levels on the susceptibility and clinical manifestations of pulmonary tuberculosis. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]., [RefSeq]; Tumor-derived interleukin 35 mediates the dissemination of gemcitabine resistance in pancreatic adenocarcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96QZ1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005143 interleukin-12 receptor binding;GO:0042163 interleukin-12 beta subunit binding;GO:0045513 interleukin-27 binding;GO:0046982 protein heterodimerization activity;GO:0005125 cytokine activity",
        "go_cellular_component": "GO:0031906 late endosome lumen;GO:0043514 interleukin-12 complex;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen",
        "go_biological_process": "GO:0032946 positive regulation of mononuclear cell proliferation;GO:0050709 negative regulation of protein secretion;GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0032700 negative regulation of interleukin-17 production;GO:0051135 positive regulation of NK T cell activation",
        "synthesized_glycan_count": 0,
        "hit_score": 20.4,
        "record_id": "P29459-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95373-1",
        "uniprot_id": "IPO7_HUMAN",
        "mass": 119517.0,
        "length": 1038,
        "protein_name": "Importin-7",
        "gene_name": "IPO7",
        "organism": "Human",
        "refseq_name": "importin-7",
        "refseq_ac": "NP_006382",
        "gene_names_uniprotkb": "IPO7; RANBP7",
        "gene_names_refseq": "IPO7; Imp7; RANBP7",
        "protein_names_uniprotkb": "Importin-7; Imp7; Ran-binding protein 7; RanBP7",
        "protein_names_refseq": "RAN-binding protein 7; importin-7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10527);  (R-HSA-9918432)",
        "pathway_count": 2,
        "publication_count": 117,
        "publication_id_list": "10209022;10228156;11237011;11682607;12665801;12853482;15592455;16408927;16704975;17081983;18669648;18691976;20068231;22223895;23301498;23481700;24366607;25576301;25645385;25880248;25892735;26154972;26208004;26375851;26768311;26878725;26992070;27383988;27397612;27600516;27846572;27862975;27920218;28228285;28228593;28514659;28832583;28834231;28904123;29242379;29331515;29351928;29393594;29493099;29508533;29557506;29632711;29769354;29786170;29789417;30315122;30379171;30410026;30429286;30484775;30779550;30833945;31154438;31217245;31222486;31530632;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33141586;33214551;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34171305;34185709;34211107;34357683;34725712;35051231;35083852;35138101;35215835;35251023;35318648;35561310;35580925;35588577;36010968;36215666;36241641;36284347;37217939;37938771;38650127;38665916;38793607;39302247;40307207;40596516;40914422;9214382;9687515",
        "class_list": "",
        "function": "(Microbial infection) Mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. Binds and mediates the nuclear import of HIV-1 Rev., [UniProtKB, PubMed, PubMed]; Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607). In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. Promotes odontoblast differentiation via promoting nuclear translocation of DLX3, KLF4, SMAD2, thereby facilitating the transcription of target genes that play a role in odontoblast differentiation (By similarity). Facilitates BMP4-induced translocation of SMAD1 to the nucleus and recruitment to the MSX1 gene promoter, thereby promotes the expression of the odontogenic regulator MSX1 in dental mesenchymal cells (By similarity). Also promotes odontoblast differentiation by facilitating the nuclear translocation of HDAC6 and subsequent repression of RUNX2 expression (By similarity). Inhibits osteoblast differentiation by inhibiting nuclear translocation of RUNX2 and therefore inhibition of RUNX2 target gene transcription (By similarity). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; IPO7 promotes pancreatic cancer progression via regulating ERBB pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Importin 7 enhances protective autophagy induced by nuclear translocation of homeobox A10 in oral squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NNM5;B2R786;Q1RMF7;Q9H177;Q9NTE3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031267 small GTPase binding;GO:0046332 SMAD binding;GO:0042393 histone binding;GO:0030695 GTPase regulator activity;GO:0061608 nuclear import signal receptor activity",
        "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:1901331 positive regulation of odontoblast differentiation;GO:1900182 positive regulation of protein localization to nucleus;GO:0045668 negative regulation of osteoblast differentiation;GO:0045786 negative regulation of cell cycle;GO:0006606 protein import into nucleus",
        "synthesized_glycan_count": 0,
        "hit_score": 12.3,
        "record_id": "O95373-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "F8WCM5-1",
        "uniprot_id": "INSR2_HUMAN",
        "mass": 21537.0,
        "length": 200,
        "protein_name": "Insulin, isoform 2",
        "gene_name": "INS-IGF2",
        "organism": "Human",
        "refseq_name": "insulin, isoform 2 precursor",
        "refseq_ac": "NP_001035835",
        "gene_names_uniprotkb": "INS-IGF2",
        "gene_names_refseq": "INS-IGF2; INSIGF",
        "protein_names_uniprotkb": "Insulin, isoform 2; INS-IGF2 readthrough transcript protein",
        "protein_names_refseq": "INS-IGF2 readthrough transcript protein; insulin, isoform 2 precursor; insulin- insulin-like growth factor 2 read-through product",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)",
        "pathway": " (hsa:723961)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "16531418;25102180;25102259;30803359;31488892;31844290;32357974;34267199",
        "class_list": "",
        "function": "GWAS of five gynecologic diseases and cross-trait analysis in Japanese., [RefSeq, PubMed]; High INS-IGF2 expression is associated with Lung Cancer., [RefSeq, PubMed]; Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects. Publication Status: Online-Only, [RefSeq, PubMed]; Periconception maternal smoking and low education are associated with dna methylation on INSIGF in the very young child., [RefSeq, PubMed]; This locus includes two alternatively spliced read-through transcript variants which align to the INS gene in the 5' region and to the IGF2 gene in the 3' region. One transcript is predicted to encode a protein which shares the N-terminus with the INS protein but has a distinct and longer C-terminus, whereas the other transcript is a candidate for nonsense-mediated decay (NMD). The transcripts are imprinted and are paternally expressed in the limb and eye. [provided by RefSeq, Jul 2008]., [RefSeq]; We identified three known loci (TCF7L2, HMGA2 and KCNQ1) and two novel loci (HLA-B and INS-IGF2) at genome-wide significance (4.15 x 10(-94) Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q1WM24",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0005179 hormone activity",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "F8WCM5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q00056-1",
        "uniprot_id": "HXA4_HUMAN",
        "mass": 34499.0,
        "length": 320,
        "protein_name": "Homeobox protein Hox-A4",
        "gene_name": "HOXA4",
        "organism": "Human",
        "refseq_name": "homeobox protein Hox-A4",
        "refseq_ac": "NP_002132",
        "gene_names_uniprotkb": "HOXA4; HOX1D",
        "gene_names_refseq": "HOX1D; HOX1; HOXA4",
        "protein_names_uniprotkb": "Homeobox protein Hox-A4; Homeobox protein Hox-1.4; Homeobox protein Hox-1D",
        "protein_names_refseq": "Dfd-like protein; Hox-1.4-like protein; homeo box A4; homeobox protein Hox-1.4; homeobox protein Hox-1D; homeobox protein Hox-A4",
        "tax_id": 9606,
        "disease": "leukemia (Disease Ontology:DOID:1240)",
        "pathway": " (hsa:3201);  (R-HSA-5617472)",
        "pathway_count": 2,
        "publication_count": 69,
        "publication_id_list": "10777502;11237011;15867264;16079151;16549775;1675427;16959974;17185360;17428788;1756725;17660710;17713478;17761849;17851529;18781158;19115252;19232136;19747919;1975088;19782034;1981366;19854132;20085832;22569366;22705304;22879880;23219899;23534758;23630040;24174538;24312487;24586203;24714562;25101834;25135475;25645385;2570724;2571574;2576652;25913784;27920218;28063628;28218747;29242379;29393594;29557506;29632046;29786170;31154438;31848261;32157095;33082556;33592498;35000421;35370463;35580925;35852388;36284347;37898994;7488013;7501971;7831296;7906964;7908827;8674428;8759021;9218805;9272954;9482740",
        "class_list": "",
        "function": "Epigenome-wide analysis reveals functional modulators of drug sensitivity and post-treatment survival in chronic lymphocytic leukaemia., [RefSeq, PubMed]; Expression Landscape and Functional Roles of HOXA4 and HOXA5 in Lung Adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; High expression of <i>HOXA4</i> in patients with glioma indicates unfavorable clinical outcomes., [RefSeq, PubMed]; In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. [provided by RefSeq, Jul 2008]., [RefSeq]; LncRNA HOTAIRM1 Activated by HOXA4 Drives HUVEC Proliferation Through Direct Interaction with Protein Partner HSPA5., [RefSeq, PubMed]; MiR-150 Attenuates Maladaptive Cardiac Remodeling Mediated by Long Noncoding RNA MIAT and Directly Represses Profibrotic Hoxa4., [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D180;O43366",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0048704 embryonic skeletal system morphogenesis;GO:0009653 anatomical structure morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q00056-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P31270-1",
        "uniprot_id": "HXA11_HUMAN",
        "mass": 34486.0,
        "length": 313,
        "protein_name": "Homeobox protein Hox-A11",
        "gene_name": "HOXA11",
        "organism": "Human",
        "refseq_name": "homeobox protein Hox-A11",
        "refseq_ac": "NP_005514",
        "gene_names_uniprotkb": "HOXA11; HOX1I",
        "gene_names_refseq": "HOX1I; HOX1; HOXA11; RUSAT1",
        "protein_names_uniprotkb": "Homeobox protein Hox-A11; Homeobox protein Hox-1I",
        "protein_names_refseq": "homeo box 1I; homeobox protein HOXA11; homeobox protein Hox-1I; homeobox protein Hox-A11",
        "tax_id": 9606,
        "disease": "radioulnar synostosis (Disease Ontology:DOID:9827); radioulnar synostosis with amegakaryocytic thrombocytopenia 1 (MONDO:MONDO:0024558)",
        "pathway": " (hsa:3207);  (R-HSA-9830674)",
        "pathway_count": 2,
        "publication_count": 21,
        "publication_id_list": "11101832;11237011;2574852;26992070;30059200;31217245;32387766;32938750;35051231;35254053;35289036;35430506;35494241;35513511;36661031;36815373;36900953;37989866;39534244;40596516;9745033",
        "class_list": "",
        "function": "Cooperation between NSPc1 and DNA methylation represses HOXA11 expression and promotes apoptosis of trophoblast cells during preeclampsia., [RefSeq, PubMed]; Decreased expression of transcription factor Homeobox A11 and its potential target genes in bladder cancer., [RefSeq, PubMed]; Endometrial Injury Upregulates Expression of Receptivity Genes in Women with Implantation Failure. Publication Status: Online-Only, [RefSeq, PubMed]; In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008]., [RefSeq]; LncRNA HOXA11-AS maintains the stemness of oral squamous cell carcinoma stem cells and reduces the radiosensitivity by targeting miR-518a-3p/PDK1., [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB, UniProtKB]; Tumor-mesothelium HOXA11-PDGF BB/TGF beta1-miR-181a-5p-Egr1 feedforward amplifier circuity propels mesothelial fibrosis and peritoneal metastasis of gastric cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 9,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 9,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 9,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D190",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0032993 protein-DNA complex;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0007501 mesodermal cell fate specification;GO:0010720 positive regulation of cell development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0001501 skeletal system development",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "P31270-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00425-1",
        "uniprot_id": "IF2B3_HUMAN",
        "mass": 63705.0,
        "length": 579,
        "protein_name": "Insulin-like growth factor 2 mRNA-binding protein 3",
        "gene_name": "IGF2BP3",
        "organism": "Human",
        "refseq_name": "insulin-like growth factor 2 mRNA-binding protein 3",
        "refseq_ac": "NP_006538",
        "gene_names_uniprotkb": "IGF2BP3; IMP3; KOC1; VICKZ3",
        "gene_names_refseq": "CT98; IGF2BP3; IMP-3; IMP3; KOC1; KOC; VICKZ3",
        "protein_names_uniprotkb": "Insulin-like growth factor 2 mRNA-binding protein 3; IGF-II mRNA-binding protein 3; IGF2 mRNA-binding protein 3; IMP-3; KH domain-containing protein overexpressed in cancer; VICKZ family member 3; hKOC",
        "protein_names_refseq": "IGF-II mRNA-binding protein 3; IGF2 mRNA-binding protein 3; KH domain containing protein overexpressed in cancer; VICKZ family member 3; cancer/testis antigen 98; insulin-like growth factor 2 mRNA-binding protein 3",
        "tax_id": 9606,
        "disease": "acquired metabolic disease (Disease Ontology:DOID:0060158)",
        "pathway": " (hsa:10643);  (R-HSA-428359)",
        "pathway_count": 2,
        "publication_count": 121,
        "publication_id_list": "10525192;10875929;11237011;11465943;11713986;12024010;12161597;12894594;12921532;15601260;15644775;16049158;16541107;16778892;16814207;17192788;17289661;17652133;18618095;18669648;19029303;19429674;19651622;19690332;20068231;20080952;20371350;21406692;22424782;22898188;23186163;23481700;23640942;24612787;24715725;25218447;25418920;25576301;26154972;26375851;26811146;26992070;27072896;27424145;27471607;27600516;28063628;28228285;28510447;28514659;28649982;28832583;28834231;28904123;29242379;29476152;29508533;29557506;29786170;29789417;30078552;30315122;30397120;30524438;30650187;30779550;30833945;31092671;31154438;31217245;31222486;31844290;31937595;31998317;32119511;32157095;32161166;32265295;32357974;32488085;32502341;32897882;32938616;32983136;33141586;33214551;33298915;33537174;33592498;33691108;33968037;33981976;34019948;34171305;34211107;34229054;34357683;34561969;34932366;35051231;35138101;35251023;35318648;35561310;35580925;35874702;36010968;36215666;36241641;36284347;37938771;38665916;38740147;38920720;39023781;39054220;39176196;39196622;39198433;9178771;9891060",
        "class_list": "",
        "function": "Association of insulin-like growth factor II mrna-binding protein 3 (IMP3) expression with prognostic and morphological factors in endometrial cancer. Publication Status: Online-Only, [RefSeq, PubMed]; IGF2BP3 participates in the pathogenesis of recurrent spontaneous abortion by regulating ferroptosis., [RefSeq, PubMed]; IGF2BP3 promotes mRNA degradation through internal m[7]G modification. Publication Status: Online-Only, [RefSeq, PubMed]; METTL5: A Potential Biomarker for Nonsmall Cell Lung Cancer That Promotes Cancer Cell Proliferation by Interacting with IGF2BP3., [RefSeq, PubMed]; Oncofetal IGF2BP3-mediated control of microRNA structural diversity in the malignancy of early-stage lung adenocarcinoma., [RefSeq, PubMed]; RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs., [UniProtKB, PubMed, PubMed, PubMed]; The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "prognostic",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A4Z5;Q63HM0;Q6MZZ2;Q86VB1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0045182 translation regulator activity;GO:0048027 mRNA 5'-UTR binding;GO:1990247 N6-methyladenosine-containing RNA reader activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule",
        "go_biological_process": "GO:0070934 CRD-mediated mRNA stabilization;GO:0007399 nervous system development;GO:0001817 regulation of cytokine production;GO:0006412 translation;GO:0017148 negative regulation of translation",
        "synthesized_glycan_count": 0,
        "hit_score": 12.4,
        "record_id": "O00425-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15225-1",
        "uniprot_id": "INE1_HUMAN",
        "mass": 5365.0,
        "length": 51,
        "protein_name": "Putative inactivation escape 1 protein",
        "gene_name": "INE1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "INE1; DXS6974E",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative inactivation escape 1 protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "9244435",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5JRR7;Q6NSX0",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "O15225-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15327-1",
        "uniprot_id": "INP4B_HUMAN",
        "mass": 104738.0,
        "length": 924,
        "protein_name": "Inositol polyphosphate 4-phosphatase type II",
        "gene_name": "INPP4B",
        "organism": "Human",
        "refseq_name": "inositol polyphosphate 4-phosphatase type II isoform 1",
        "refseq_ac": "NP_001095139",
        "gene_names_uniprotkb": "INPP4B",
        "gene_names_refseq": "INPP4B",
        "protein_names_uniprotkb": "Inositol polyphosphate 4-phosphatase type II; 3.1.3.66; Type II inositol 3,4-bisphosphate 4-phosphatase",
        "protein_names_refseq": "4-phosphatase II; inositol polyphosphate 4-phosphatase II; inositol polyphosphate 4-phosphatase type II isoform 1; inositol polyphosphate-4-phosphatase, type II, 105kDa; type II inositol 3,4-bisphosphate 4-phosphatase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8821);  (R-HSA-1660499);  (R-HSA-1660516);  (R-HSA-1855183)",
        "pathway_count": 4,
        "publication_count": 154,
        "publication_id_list": "10194451;10224048;10419465;10555148;10559940;10593988;10753883;10766823;10805725;10822173;11001876;11084340;11237011;11279162;11302699;11349134;11604140;11676921;11706043;11733541;11877430;11923287;12101241;12118066;12324459;12422219;12536145;12646134;12808147;12847086;12847286;12890864;1377913;14516276;14617813;14660569;15024000;15080793;15107860;15135396;15464023;15474001;15504367;15716355;15797027;15840652;16154996;16399794;16476736;16522682;1655747;16787938;16914545;16979564;17008356;17068342;1718960;17245604;17322306;17556371;17651088;17846126;18093523;18364358;18452278;18524850;18753295;18950639;19038970;19647222;19896968;20534812;21081650;21204784;22037487;22647598;23519112;23758345;23818870;24070612;24591580;24715725;25495341;25576301;25645385;25869668;25892735;26154972;26496610;26811146;27600516;27862975;28832583;29242379;29493099;29508533;29557506;29769354;29786170;30429286;31217245;31844290;32157095;32387766;32488085;32502341;32938616;33141586;33392160;33968037;34171305;34211107;34509645;35051231;35154160;35318648;35580925;36215666;36241641;36284347;37217939;37389566;37938771;38246071;38318760;39120584;39507966;7608176;7624799;7628435;7721860;7761412;8006039;8390685;8681945;8723348;8769125;8999962;9094719;9113989;9211928;9286278;9295334;9367159;9428629;9430698;9514948;9516481;9524259;9593664;9660759;9660833;9811831;9830063",
        "class_list": "",
        "function": "Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612)., [UniProtKB, PubMed, PubMed, PubMed]; INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]., [RefSeq]; INPP4B promotes PDAC aggressiveness via PIKfyve and TRPML-1-mediated lysosomal exocytosis., [RefSeq, PubMed]; Investigating the multifaceted cooperation of autophagy, PI3K/AKT signaling pathways, and INPP4B gene in de novo acute myeloid leukemia patients., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Regulation of B-1 cell numbers and B cell-mediated antibody production by Inpp4b., [RefSeq, PubMed]; Role of INPP4B in the proliferation, migration, invasion, and survival of human endometrial cancer cells., [RefSeq, PubMed]; [Preliminary Study of the Role of INPP4B in Promoting Colorectal Cancer Metastasis and the Mechanisms Involved]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2TAI2;Q5XLE7;Q6IN59;Q6PJB4",
        "ec_number_list": "3.1.3.66",
        "go_molecular_function": "GO:0017161 inositol-1,3,4-trisphosphate 4-phosphatase activity;GO:0052828 inositol-3,4-bisphosphate 4-phosphatase activity;GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0007165 signal transduction;GO:0006661 phosphatidylinositol biosynthetic process;GO:0043647 inositol phosphate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 15.7,
        "record_id": "O15327-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43837-1",
        "uniprot_id": "IDH3B_HUMAN",
        "mass": 42184.0,
        "length": 385,
        "protein_name": "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial",
        "gene_name": "IDH3B",
        "organism": "Human",
        "refseq_name": "isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform e precursor",
        "refseq_ac": "NP_001317692",
        "gene_names_uniprotkb": "IDH3B",
        "gene_names_refseq": "IDH3B; RP46",
        "protein_names_uniprotkb": "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; Isocitric dehydrogenase subunit beta; NAD(+)-specific ICDH subunit beta",
        "protein_names_refseq": "NAD(+)-specific ICDH subunit beta; isocitrate dehydrogenase (NAD(+)) 3 beta; isocitrate dehydrogenase 3 (NAD(+)) beta; isocitrate dehydrogenase 3 (NAD+) beta; isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform e precursor; isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; isocitric dehydrogenase subunit beta",
        "tax_id": 9606,
        "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); retinitis pigmentosa 46 (Disease Ontology:DOID:0110409)",
        "pathway": " (hsa:3420);  (R-HSA-71403)",
        "pathway_count": 2,
        "publication_count": 75,
        "publication_id_list": "1052766;10601238;10673423;10727444;11237011;11278619;12207025;13181903;14249115;14555658;14832224;14946179;15234968;15652751;15877282;15987702;16143825;16737955;16740313;17182618;17432878;17668387;18806796;18914071;1946331;19608861;2005110;20435888;20847235;23564345;23747254;25564869;26992070;27189937;27374498;28098230;28139779;28228285;28834231;28887308;28904123;29242379;29393594;29557506;29632046;30315122;30761759;30844107;31053633;31154438;31217245;31844290;32157095;32161166;32387766;32619879;33058874;33537174;33912179;34229054;34357683;35366151;35580925;36139014;36420423;37217939;37938771;38679634;8200987;8616157;9765290;9765291;9792106;9792662;9809442",
        "class_list": "",
        "function": "A positive feedback inhibition of isocitrate dehydrogenase 3beta on paired-box gene 6 promotes Alzheimer-like pathology. Erratum:[Signal Transduct Target Ther. 2024 Jul 15;9(1):187. doi: 10.1038/s41392-024-01904-2. PMID: 39009590] Publication Status: Online-Only, [RefSeq, PubMed]; High IDH3B expression is associated with esophageal squamous cell carcinoma., [RefSeq, PubMed]; Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2016]., [RefSeq]; Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Polymorphism on chromosome 20p13 near the IDH3B gene is associated with uterine prolapse., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDR1;D3DVX2;D3DVX3;O95106;Q5JXS8;Q9NQ06;Q9NQ07;Q9NUZ0;Q9UEX0;Q9UG99",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0009055 electron transfer activity;GO:0051287 NAD binding;GO:0004449 isocitrate dehydrogenase (NAD+) activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045242 isocitrate dehydrogenase complex (NAD+)",
        "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006102 isocitrate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "O43837-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75054-1",
        "uniprot_id": "IGSF3_HUMAN",
        "mass": 135196.0,
        "length": 1194,
        "protein_name": "Immunoglobulin superfamily member 3",
        "gene_name": "IGSF3",
        "organism": "Human",
        "refseq_name": "immunoglobulin superfamily member 3 isoform 2 precursor",
        "refseq_ac": "NP_001007238",
        "gene_names_uniprotkb": "IGSF3; EWI3; KIAA0466",
        "gene_names_refseq": "EWI-3; IGSF3; LCDD; V8",
        "protein_names_uniprotkb": "Immunoglobulin superfamily member 3; EWI-3; Glu-Trp-Ile EWI motif-containing protein 3; IgSF3",
        "protein_names_refseq": "glu-Trp-Ile EWI motif-containing protein 3; immunoglobin superfamily, member 3; immunoglobulin superfamily member 3 isoform 2 precursor",
        "tax_id": 9606,
        "disease": "lacrimal duct obstruction (Disease Ontology:DOID:13929); familial congenital nasolacrimal duct obstruction (MONDO:MONDO:0007871)",
        "pathway": " (hsa:3321)",
        "pathway_count": 1,
        "publication_count": 53,
        "publication_id_list": "10.1101/2023.09.13.557529;11504738;14656960;19413330;20068231;23090970;24190977;24372406;25645385;25892735;26992070;27600516;28228285;28904123;29242379;29557506;29632711;29741879;29769354;30192525;30315122;30484775;30573663;30779550;31020640;31217245;31560140;31844290;32157095;32350084;32357974;32387766;32488085;32573489;32938616;32983136;33592498;33633747;33912179;33968037;33981976;34087483;34357683;34433824;35051231;35154160;35251023;36215666;36241641;37074911;37217939;8918585;9790749",
        "class_list": "",
        "function": "Based on IGSF3 mutation in a family with congenital nasolacrimal duct obstruction we conclude that the disruption of IGSF3 is the very likely cause of autosomal recessive nasolacrimal duct obstruction., [RefSeq, PubMed]; IGSF3 mutation identified in patient with severe COPD alters cell function and motility. Publication Status: Online-Only, [RefSeq, PubMed]; The IGSF23 mutation led to decreased c-Fos and NFATC1 expression levels by inhibiting the mitogen-activated protein kinase signalling pathways, [RefSeq, PubMed]; The protein encoded by this gene is an immunoglobulin-like membrane protein containing several V-type Ig-like domains. A mutation in this gene has been associated with bilateral nasolacrimal duct obstruction (LCDD). [provided by RefSeq, Jun 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 7,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 8,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 8,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 8,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 52,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 15,
        "disease_count": 2,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NJZ6;A6NMC7",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane",
        "go_biological_process": "GO:0032808 lacrimal gland development",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "O75054-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95050-1",
        "uniprot_id": "INMT_HUMAN",
        "mass": 28891.0,
        "length": 263,
        "protein_name": "Indolethylamine N-methyltransferase",
        "gene_name": "INMT",
        "organism": "Human",
        "refseq_name": "indolethylamine N-methyltransferase isoform 2",
        "refseq_ac": "NP_001186148",
        "gene_names_uniprotkb": "INMT",
        "gene_names_refseq": "INMT; TEMT",
        "protein_names_uniprotkb": "Indolethylamine N-methyltransferase; 2.1.1.49; 2.1.1.96; Amine N-methyltransferase; Aromatic alkylamine N-methyltransferase; Arylamine N-methyltransferase; Indolamine N-methyltransferase; TEMT; Thioether S-methyltransferase",
        "protein_names_refseq": "amine N-methyltransferase; aromatic alkylamine N-methyltransferase; arylamine N-methyltransferase; indolamine N-methyltransferase; indolethylamine N-methyltransferase isoform 2; nicotine N-methyltransferase; thioether S-methyltransferase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11185);  (R-HSA-2408552)",
        "pathway_count": 2,
        "publication_count": 12,
        "publication_id_list": "10552930;15014171;26537946;29557506;30429286;31154438;31310642;31848261;3350800;34587977;35051231;38159853",
        "class_list": "",
        "function": "Analysis of 254C and 254F variants of hINMT reveals differences in methylation of tryptamine, dimethylsulfide and dimethylselenide Erratum:[PLoS One. 2019 Oct 1;14(10):e0223546. doi: 10.1371/journal.pone.0223546. PMID: 31574131] Publication Status: Online-Only, [RefSeq, PubMed]; Differential molecular mechanisms of substrate recognition by selenium methyltransferases, INMT and TPMT, in selenium detoxification and excretion., [RefSeq, PubMed]; Functions as a thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds., [UniProtKB, PubMed]; Genome-wide association studies in populations in Argentina/Bangladeshi: Three SNPs in INMT (rs6970396, rs1061644, rs4270015) are associated with production of trimethylselenonium (TMSe); urinary Se excretion is up-regulated in TMSe-producing women., [RefSeq, PubMed]; N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream MINDY4 (aka FAM188B) gene. In rodents and other mammals such as cetartiodactyla this gene is in the opposite orientation compared to its orientation in human and other primates and this gene appears to have been lost in carnivora and chiroptera. [provided by RefSeq, Jul 2019]., [RefSeq]; Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B8ZZ69;Q3KP49;Q9P1Y2;Q9UBY4;Q9UHQ0",
        "ec_number_list": "2.1.1.49;2.1.1.96",
        "go_molecular_function": "GO:0004790 thioether S-methyltransferase activity;GO:0030748 amine N-methyltransferase activity;GO:0008170 N-methyltransferase activity",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0009636 response to toxic substance;GO:0009308 amine metabolic process;GO:0032259 methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "O95050-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P01308-1",
        "uniprot_id": "INS_HUMAN",
        "mass": 11981.0,
        "length": 110,
        "protein_name": "Insulin",
        "gene_name": "INS",
        "organism": "Human",
        "refseq_name": "insulin preproprotein",
        "refseq_ac": "NP_000198",
        "gene_names_uniprotkb": "INS",
        "gene_names_refseq": "IDDM1; IDDM2; IDDM; ILPR; INS; IRDN; MODY10; PNDM4",
        "protein_names_uniprotkb": "Insulin",
        "protein_names_refseq": "insulin preproprotein; preproinsulin; proinsulin",
        "tax_id": 9606,
        "disease": "disease of metabolism (Disease Ontology:DOID:0014667); maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); permanent neonatal diabetes mellitus (Disease Ontology:DOID:0060639); type 1 diabetes mellitus 2 (Disease Ontology:DOID:0110741); maturity-onset diabetes of the young type 10 (Disease Ontology:DOID:0111108); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); gestational diabetes (Disease Ontology:DOID:11714); neonatal diabetes mellitus (Disease Ontology:DOID:11717); pancreatic cancer (Disease Ontology:DOID:1793); hyperuricemia (Disease Ontology:DOID:1920); hyperinsulinism (Disease Ontology:DOID:2018); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); insulinoma (Disease Ontology:DOID:3892); cholangiocarcinoma (Disease Ontology:DOID:4947); osteoarthritis (Disease Ontology:DOID:8398); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970); hyperproinsulinemia (MONDO:MONDO:0014535); diabetes mellitus, permanent neonatal 4 (MONDO:MONDO:0030089)",
        "pathway": " (hsa:3630);  (R-HSA-210745);  (R-HSA-264876);  (R-HSA-422085);  (R-HSA-422356);  (R-HSA-6807878);  (R-HSA-6811558);  (R-HSA-74713);  (R-HSA-74749);  (R-HSA-74751);  (R-HSA-74752);  (R-HSA-77387);  (R-HSA-9615017);  (R-HSA-9768919);  (R-HSA-977225)",
        "pathway_count": 15,
        "publication_count": 458,
        "publication_id_list": "10052452;10097139;10102273;10194514;10206966;10217147;10218944;10318838;10319874;10330297;10342826;10358014;10391242;10411933;10424882;10427092;10445031;10480625;10521251;10526167;10559959;10583407;10604470;10671200;10679020;10761932;10773014;10866047;10868950;10903204;10913147;10921873;10956649;11035033;11063744;11075717;11078440;11078469;11089560;11172815;11237011;11264248;11278841;11285137;11306556;11401442;11409713;11461920;11462236;11467836;11493706;11577798;11590439;11600536;11689559;11703931;11707400;11716850;11726511;11737239;11748249;11756331;11779849;11779865;11780755;11815450;11815460;11815462;11815463;11873862;118839;11904301;12047556;12050285;12070132;12196472;12239572;12354137;12388752;12403834;12414809;12454989;12475777;12493740;12553549;12634853;12684222;1270801;12764427;12887316;12952878;1309948;1325671;13459201;1433291;14426955;14506261;14514350;14567678;14599721;14615605;14617756;14654841;14701734;14704853;14742712;15000528;15037235;15064394;15069075;15070567;15126574;15142980;15256494;1528899;15305887;15316008;15331542;15504896;15572341;15585596;15604212;15616190;15632110;15678092;15728195;15728483;15813748;15878854;15878873;15889096;15962837;1601997;16030147;16030262;16158220;16158222;16174740;16263242;16271887;1631136;16332676;16407158;16443778;16456541;1646635;16513675;16556766;16574064;16633337;16714477;16723730;16783365;16799559;1680566;16814735;16840535;16868084;16868246;16912714;16926190;16940185;16984975;17021801;17051221;17065344;17130554;17200115;17253781;17259518;17274799;17289852;17327428;17360540;17380317;17425515;17429068;17451557;17595255;17660294;17760859;17855560;17900700;17919183;17927562;17956946;18065497;18070888;18086915;18162464;18162506;18182008;18192540;18283113;18305140;18346985;1837051;18385016;18390725;18396350;18406720;18443287;18449172;18484335;1849145;18524849;18596924;18802479;18809720;1898986;19011241;19015319;19109418;19164740;19280057;19292763;19296914;19321446;19327128;1957170;19576174;19587354;19628676;19631211;19658395;19758564;19828817;19837003;20086079;20226046;20308425;20357002;2036420;20427317;20628762;20637885;20639478;20676056;20807650;20977903;21091435;21145486;2118650;21219331;21308844;21368041;21536589;21636247;21689688;21713314;21844168;21884975;2195544;2196279;21998398;22013193;22065755;22069251;22069252;22087256;22094269;22102287;22131221;22245737;22304919;2271664;23255554;23395677;23813966;23839779;23992284;24028821;24040102;24089515;2409350;24119662;24291638;24387802;24465693;24806965;24833601;24844227;24893886;25091901;25157096;25249579;25423173;25436559;25492864;25523424;25831495;25992863;26018760;26085090;26417681;26517901;26668317;26686862;2669954;26718497;26807092;26826277;26944932;27183389;27472814;27547294;27798614;279930;28181734;2822027;28794283;2900981;29108130;29196783;29343547;29429978;29438107;29506985;29596046;29851415;2986535;29955175;29967002;30008714;30275329;3035556;30418433;30428974;3053705;3061785;30626607;3080684;3094007;31067468;31150624;31184304;3142462;3166375;31896552;32157332;32184781;32229538;32723473;33414250;33485965;33841327;34171305;34336205;34433824;34611019;3470784;35007324;3517644;3537011;36207582;36284347;36309486;36619657;3675579;37406136;37481700;37561596;3896518;39066679;39074636;3923453;39286976;39425874;39600694;4019786;4443293;4698553;4698555;4803504;503234;5101771;5560404;6019353;6243748;6248962;6312455;6424111;6424440;6435940;6927840;7589840;7593639;7626024;7641683;7691276;7739560;7781591;7929063;7929812;8001155;8027028;8033412;8097946;8114934;8128252;8132710;8159701;8221884;8253837;8276779;8300632;8358440;8421693;8457197;8464497;8490014;8505331;8529129;8620540;8636227;8675920;8682206;8702728;8760075;8810325;8816480;8870004;8916141;8987985;8991093;8995282;8997178;9006323;9054935;9114004;9119530;9150144;9166668;9177194;9207799;9235985;9244307;9288971;9323141;9350615;9380700;9382863;9405360;9490716;9609109;9609114;9609117;9631292;9671725;9690470;9726229;9739505;9751501;9751720;9793760;9862427;9914469;9990005",
        "class_list": "",
        "function": "Association of polymorphism of NLRP3, ICAM-1, PTPN22, INS genes in childhood onset type 1 diabetes in a Pakistani population. Publication Status: Online-Only, [RefSeq, PubMed]; Findings reveal critical interactions underlying the allele-dependent INS expression and INS-mediated risk of T1D, [RefSeq, PubMed]; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes diabetes mellitus, maturity-onset diabetes of the young type 10 and hyperproinsulinemia. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq, May 2020]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 25,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5EEX2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0002020 protease binding;GO:0005158 insulin receptor binding;GO:0042802 identical protein binding;GO:0005159 insulin-like growth factor receptor binding;GO:0005179 hormone activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0005796 Golgi lumen",
        "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0050709 negative regulation of protein secretion;GO:0045818 negative regulation of glycogen catabolic process;GO:0045922 negative regulation of fatty acid metabolic process;GO:0046631 alpha-beta T cell activation",
        "synthesized_glycan_count": 0,
        "hit_score": 45.9,
        "record_id": "P01308-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P01344-1",
        "uniprot_id": "IGF2_HUMAN",
        "mass": 20140.0,
        "length": 180,
        "protein_name": "Insulin-like growth factor 2",
        "gene_name": "IGF2",
        "organism": "Human",
        "refseq_name": "insulin-like growth factor 2 isoform 1 preproprotein",
        "refseq_ac": "NP_000603",
        "gene_names_uniprotkb": "IGF2; IGF-2; PP1446",
        "gene_names_refseq": "C11orf43; GRDF; IGF-II; IGF2; PP9974; SRS3",
        "protein_names_uniprotkb": "Insulin-like growth factor 2; IGF-II; Insulin-like growth factor II; Somatomedin-A; T3M-11-derived growth factor",
        "protein_names_refseq": "T3M-11-derived growth factor; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor 2 isoform 1 preproprotein; insulin-like growth factor type 2; preptin",
        "tax_id": 9606,
        "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); alcohol-associated liver disease (Disease Ontology:DOID:0070658); congenital disorder of glycosylation Ia (Disease Ontology:DOID:0080552); type 1 diabetes mellitus 2 (Disease Ontology:DOID:0110741); Alzheimer's disease (Disease Ontology:DOID:10652); osteoporosis (Disease Ontology:DOID:11476); Lewy body dementia (Disease Ontology:DOID:12217); alcoholic neuropathy (Disease Ontology:DOID:14183); Parkinson's disease (Disease Ontology:DOID:14330); Silver-Russell syndrome (Disease Ontology:DOID:14681); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); ventricular septal defect (Disease Ontology:DOID:1657); multiple sclerosis (Disease Ontology:DOID:2377); brain infarction (Disease Ontology:DOID:3454); choriocarcinoma (Disease Ontology:DOID:3594); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); multiple system atrophy (Disease Ontology:DOID:4752); liver cirrhosis (Disease Ontology:DOID:5082); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); gastrointestinal system disease (Disease Ontology:DOID:77); osteoarthritis (Disease Ontology:DOID:8398); ulcerative colitis (Disease Ontology:DOID:8577); type 2 diabetes mellitus (Disease Ontology:DOID:9352); meningitis (Disease Ontology:DOID:9471); type 1 diabetes mellitus (Disease Ontology:DOID:9744); Silver-Russell syndrome 3 (MONDO:MONDO:0014663)",
        "pathway": " (hsa:3481);  (R-HSA-114608);  (R-HSA-2404192);  (R-HSA-2428928);  (R-HSA-2428933);  (R-HSA-381426);  (R-HSA-9943962)",
        "pathway_count": 7,
        "publication_count": 183,
        "publication_id_list": "10.1038/emboj.2013.79;10026136;10077652;10218588;10512690;10531310;10614670;10681634;10810289;10898936;10912521;10921920;10951195;10990447;11158056;11250653;11264294;11274398;11316748;11316783;11356022;11448941;11507205;11522292;11557037;11606061;11739083;11744694;11751371;11788658;12241545;12379487;12466191;12586351;12639902;12810533;12904166;1310594;1370451;1383255;1435334;14630798;14712218;15126567;15182363;15297306;15308688;15359740;15469690;15485880;15498874;15525596;15642270;1569071;15960975;16040806;16095617;16531418;16754202;16878130;16912056;16949368;1697749;16981855;17027977;17047378;17143291;17249697;17312271;17350655;17408801;17603073;17985932;18046459;18378692;1845984;18563800;19066168;19139090;19531498;19838169;20453063;20842449;21899694;22140443;22171320;23234360;23285124;23408615;23584533;23640497;2450353;24593700;2476804;2479552;26091039;26154720;26992070;2722836;27862975;2839228;28514659;28533432;28796236;28873464;29314611;29557506;2969892;29786170;3002851;3011795;3013881;3015966;3019338;30237853;30429286;30459171;31092671;31154438;31492838;3167054;31844290;31848261;32350084;33592498;34171305;3476948;35051231;35251023;35580925;36284347;3652904;3653397;3683205;3881277;38874740;38912889;38924829;6189745;6261960;6382021;6382022;6457647;658418;7493944;7519608;7523391;7525263;7525634;7525824;7527330;7527339;7538844;7541045;7543116;7559478;7559507;7588299;7633596;7683646;7689487;7730145;7876259;8033892;8385745;8467233;8530377;8662806;8781553;8810325;8817670;8894645;8964575;9003010;9497324;9553137;9690470;9709957;9733769;9786878;9832424;9852124;9922210",
        "class_list": "",
        "function": "Cyclic negative pressure promotes chondrocyte growth: Association of IGF-2 with EGR-1. Publication Status: Online-Only, [RefSeq, PubMed]; IGF2 gene is imprinted, with expression from only the paternal allele., [RefSeq, PubMed]; Maternal perceived stress and green spaces during pregnancy are associated with adult offspring gene (NR3C1 and IGF2/H19) methylation patterns in adulthood: A pilot study., [RefSeq, PubMed]; Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3., [UniProtKB, PubMed]; The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]., [RefSeq]; Unmasking early colorectal cancer clues: in silico and in vitro investigation of downregulated IGF2, SOCS1, MLH1, and CACNA1G in SSA polyps. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 3,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 8,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 8,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 8,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 11,
        "disease_count": 29,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KX48;B7WP08;C9JAF2;E3UN45;P78449;Q14299;Q1WM26;Q9UC68;Q9UC69",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0005178 integrin binding;GO:0005159 insulin-like growth factor receptor binding;GO:0005179 hormone activity;GO:0008083 growth factor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031093 platelet alpha granule lumen",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 20.3,
        "record_id": "P01344-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P01743-1",
        "uniprot_id": "HV146_HUMAN",
        "mass": 12933.0,
        "length": 117,
        "protein_name": "Immunoglobulin heavy variable 1-46",
        "gene_name": "IGHV1-46",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "IGHV1-46",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 1-46; Ig heavy chain V-I region DOT; Ig heavy chain V-I region HG3; Ig heavy chain V-I region Mot",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (R-HSA-166663);  (R-HSA-173623);  (R-HSA-198933);  (R-HSA-202733);  (R-HSA-2029481);  (R-HSA-2029482);  (R-HSA-2029485);  (R-HSA-2168880);  (R-HSA-2454202);  (R-HSA-2730905);  (R-HSA-2871796);  (R-HSA-2871809);  (R-HSA-2871837);  (R-HSA-5690714);  (R-HSA-9664323);  (R-HSA-9664422);  (R-HSA-9679191);  (R-HSA-977606);  (R-HSA-983695)",
        "pathway_count": 19,
        "publication_count": 538,
        "publication_id_list": "10026222;10051622;10068651;10072481;1008494;10087012;10219243;10224668;10381560;10395673;10432293;10496324;10498607;10499918;10523831;10531307;10556826;10559936;10579907;10606205;10648173;1067618;10702308;10706702;10724160;10746781;10764623;10770799;10781580;1081164;10838074;10860980;10861086;10878810;10880360;10882101;10917520;10925294;10983984;10995437;11007481;11015619;11030334;11042164;11071869;11090634;11157975;11196644;11207550;11226282;11231582;11256994;11265639;11276226;11278486;11306453;11325957;11329366;11340081;11340169;11340299;11368773;11395409;11425868;11449366;11460167;11489943;11513152;11553796;11556966;11564780;11606584;11694537;11713268;11747816;11749377;11772397;11779189;11804587;11807247;11812992;11829459;11854399;11857637;11858820;11861603;11877257;11901194;11909947;11939578;11955593;11955595;11955599;11994425;12055245;12055636;12070135;12105426;12117970;12181444;12189515;12208882;12213210;12213321;12217391;12235133;12396008;12417718;12453414;12456653;12469115;12473184;12483297;1249422;1252417;12573241;12588680;12660731;12670394;12670955;12743368;12782713;12869549;12975316;1314888;13342742;13472068;1372004;1372019;1374290;1375264;1376928;1386357;14280442;14514672;14529530;14615387;14630197;14676198;14719373;14970179;15000751;15010370;15034010;15040784;15125833;15136729;15155468;15161916;15187135;15187158;15199963;15294978;15304001;15327770;15448162;15452139;1550550;15509800;15528364;15534202;15536084;15541655;15542058;15548136;15580655;15607800;15657136;15681301;15686303;15697213;15721307;15778510;15781451;15800062;15809313;15851719;15864273;15879134;1591491;15947085;1599430;16014749;16046400;16079145;16091383;16115318;16129954;16186825;16189277;16192651;16252004;16258728;16262445;16297198;16339513;16356853;16356856;16380601;16408005;16456001;1646599;16497229;16522641;16546099;16551255;16585556;16641196;16678913;16691243;16702231;16737824;16737840;16754721;16778136;16783819;16831874;16849466;16880808;16893496;16904340;16906149;16921024;16928187;16938345;16978534;16999828;17008602;1702903;17045824;17047224;1705565;17057721;17064312;17099249;17102136;17116209;17135271;17158449;17167768;17172599;17182573;17188549;17202194;17224452;17237375;17308335;17322099;17337780;17379836;17428801;17442946;17452328;17452516;17486119;17496917;17498065;17502104;17505016;17505110;17525755;17540168;17563375;17576170;17580308;17590538;17600130;17615384;17625065;17662961;17845074;17948050;17993265;18006696;18025150;18031695;18037897;18052078;18055229;18070890;18187424;18209062;18234675;18296442;18326500;18391171;18420269;18556779;18593354;18596693;18772140;18818202;18843204;18995841;19124833;19149696;19206206;19249086;19279206;19324878;19359216;19372136;19574218;19592130;19592646;19650691;19741094;19909365;19955216;2011584;20176268;20192804;20223979;20300203;20430887;20685844;20730098;20920479;21037092;21193412;21241660;21408196;21419341;21469132;21653832;21659548;21788512;21800138;21822214;21841309;21877119;21966355;22158414;22180443;22210847;22396535;22401777;22492620;22552008;22798961;22802338;22814904;22922649;2303036;2304550;23487775;23641311;23675550;23695528;23836650;23929856;23945545;24043627;2420889;24272870;24305946;24584101;24600447;2465906;2466593;2474607;24764293;2481448;25200415;2529342;2538457;25703557;25716998;25801024;26002965;26284469;26300885;27846572;2806549;2833500;2833705;28425720;293688;293746;2956252;2971659;29945920;301546;30201761;3084950;31048504;31217245;32983136;34932366;3500860;35154160;3848661;3891754;4074707;4098172;4327491;4589993;468991;496916;5135507;6019133;6214588;6219696;6222381;6230668;6238120;6298778;6334079;6335036;6454142;6480598;6607952;670886;6849882;6906228;702059;70787;7263686;7287740;7378053;7391570;7391573;7509040;7512959;7516890;7517665;7518558;7521687;7521878;7522622;7524079;7526393;7528218;7528327;7530449;7531291;7538118;7542404;7542572;7561031;7592958;760802;761607;7618087;7687428;7687539;7688784;7690834;7691807;7691959;7706301;7718892;7737190;7848918;7855889;7927516;7997270;803528;8071371;814163;8163536;8163559;8166770;8178173;8226994;8228618;8306975;8314844;8327478;8340414;8345200;8424694;8475064;8493579;8495193;8538770;8541526;8611682;8629002;8630736;8631904;8657103;8663278;8673706;8702662;8786315;8799126;8809042;8855948;8862523;8910399;8947047;8986718;8995416;8995445;9000504;9038722;9042338;9050880;9052782;9099726;9162098;9169774;9199344;9235916;9242610;9285412;9295288;9295361;9314552;9314561;9326643;9341187;9382878;9382888;9477973;9480991;9547345;9600938;9601638;9639556;9693095;9697839;9700512;9705280;9705962;971416;9730896;9763524;978134;9799231;9843499;9857068;9883880;9885284;9890995;9973503;9989831",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 469,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A0B4J1V4;P06326;P80421",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0006955 immune response;GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 53.9,
        "record_id": "P01743-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P01854-2",
        "uniprot_id": "IGHE_HUMAN",
        "mass": 59539.0,
        "length": 546,
        "protein_name": "Immunoglobulin heavy constant epsilon",
        "gene_name": "IGHE",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "IGHE",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy constant epsilon; Ig epsilon chain C region ND; Ig epsilon chain C region",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); allergic bronchopulmonary aspergillosis (Disease Ontology:DOID:13166); allergic rhinitis (Disease Ontology:DOID:4481); pulmonary eosinophilia (Disease Ontology:DOID:9498)",
        "pathway": " (R-HSA-2454202);  (R-HSA-2730905);  (R-HSA-2871796);  (R-HSA-2871809);  (R-HSA-2871837);  (R-HSA-6785807)",
        "pathway_count": 6,
        "publication_count": 215,
        "publication_id_list": "10023775;10026222;10068651;10072481;10219247;10369418;10395673;10510379;10523831;10586089;10702308;10838074;10860980;10867011;10882101;10917520;11007481;11015619;11030334;11058569;11084045;11090634;11104795;11120780;11278437;11278486;11278729;11306453;11325957;11340169;11340299;11356008;11368773;11395409;11404481;11460167;11463377;11713268;11772397;11804587;11960372;12217391;12223527;12242343;12473184;12573241;12600988;12660731;12670394;12670955;12832402;12975316;14514672;14630197;14634100;14712222;15010370;15116091;15125833;15261459;15327770;15548136;15557177;15584925;15686303;15805299;15869882;15950906;16007214;16048438;16107692;1613458;16172256;16186825;16205632;16236134;16252004;16356853;16356856;16397018;16451196;16456001;16510571;16540365;16606674;16831874;16938345;16978534;17047224;17135271;17158449;1727861;17427945;17428801;17458857;17496917;17498065;17502104;17540168;17572495;17576170;17948050;17993265;18243101;18296442;18353781;18447642;18644974;18772140;19124156;19124833;19185846;19397496;19574218;19592646;19909365;20176268;20300203;20458139;20493732;20685844;21102457;21252155;21653832;2167225;21689689;21730069;21937440;21966355;21994466;22046235;22158414;22205702;22383755;22693070;22798961;22851691;23086340;23090970;23124025;23172665;23455323;23555662;23967200;24097101;24308486;24698316;24743777;25200415;25234944;25629393;25824821;26687240;2833705;28832583;29671580;30956175;33840121;3796618;4361830;4361831;6234164;6288268;6300763;6327276;6815656;7510216;7512451;7518558;7526393;7528327;7529288;7544003;7795521;7796300;7855889;7898939;7907877;7995941;7997270;8071371;8085155;8114916;8493579;8551243;8602263;8621622;8629002;8630736;8631904;8645991;8663118;8663278;8668165;8673706;8702662;8797861;8799126;8816495;8910399;8976175;8986718;8995445;9013879;9099726;9199344;9295361;9477973;9639556;9651359;9723655;9736340;9822675;9874564;9989831",
        "class_list": "",
        "function": "Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed]; Constant region of membrane-bound IgE (long mIgE), part of the B cell receptor complex (BCR). Upon antigen cross-linking triggers quick BCR signaling, ensuring survival of IgE-switched B cells and differentiation into plasma cells, thus regulating both primary and memory IgE responses., [UniProtKB, PubMed, PubMed]; Constant region of membrane-bound IgE (short mIgE), part of the B cell receptor complex (BCR). Upon antigen cross-linking initiates slower but sustained BCR signaling that negatively regulates mature B cell proliferation., [UniProtKB, PubMed]; Constant region of secreted IgE, also known as the Fc region of IgE antibody. Mediates IgE effector functions on myeloid and lymphoid cells primarily via two Fc receptors, the high-affinity IgE Fc receptor complex/FCER1A:MS4A2:FCGR1A and the low-affinity FCER2 receptor, which upon antigen/allergen cross-linking initiate signaling pathways that lead to immune cell activation and differentiation (PubMed:2167225, PubMed:25629393, PubMed:33840121, PubMed:7544003, PubMed:8114916, PubMed:8551243). Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions (PubMed:25629393, PubMed:33840121, PubMed:7544003, PubMed:8114916, PubMed:8551243). Stimulates the high-affinity IgE Fc receptor complex/FCER1A:MS4A2:FCGR1A on mast cells, basophils and eosinophils leading to secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes (PubMed:25629393, PubMed:8114916, PubMed:8551243). On macrophages, cross-linking of FCER2 by IgE immune complexes induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway (PubMed:7544003). Activates macrophages to kill tumor cells via antigen-specific antibody-dependent cytotoxicity (ADCC). Triggers differentiation of quiescent M0 macrophages toward M1 state and reprograms M2 macrophages toward a proinflammatory state with antitumor functions (PubMed:30956175). Stimulates FCER2 on B cells and initiates IgE-dependent antigen uptake and presentation to T cells (PubMed:2167225)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 6,
        "mined_n_glycosites": 6,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 7,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 8,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 8,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 8,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 16,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 106,
        "disease_count": 4,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A286YES5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0042571 immunoglobulin complex, circulating;GO:0071744 IgE B cell receptor complex",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0019731 antibacterial humoral response;GO:0042113 B cell activation;GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 33.1,
        "record_id": "P01854-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P08476-1",
        "uniprot_id": "INHBA_HUMAN",
        "mass": 47442.0,
        "length": 426,
        "protein_name": "Inhibin beta A chain",
        "gene_name": "INHBA",
        "organism": "Human",
        "refseq_name": "inhibin beta A chain preproprotein",
        "refseq_ac": "NP_002183",
        "gene_names_uniprotkb": "INHBA",
        "gene_names_refseq": "EDF; FRP; INHBA",
        "protein_names_uniprotkb": "Inhibin beta A chain; Activin beta-A chain; EDF; Erythroid differentiation protein",
        "protein_names_refseq": "FSH-releasing protein; Inhibin, beta-1; activin beta-A chain; erythroid differentiation factor; erythroid differentiation protein; follicle-stimulating hormone-releasing protein; inhibin beta A chain preproprotein; inhibin beta A chain; inhibin beta A subunit; inhibin, beta A (activin A, activin AB alpha polypeptide)",
        "tax_id": 9606,
        "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); gestational diabetes (Disease Ontology:DOID:11714); prolapse of female genital organ (Disease Ontology:DOID:1284); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); retinal degeneration (Disease Ontology:DOID:8466)",
        "pathway": " (hsa:3624);  (R-HSA-1502540);  (R-HSA-201451);  (R-HSA-209822);  (R-HSA-2473224);  (R-HSA-9839406)",
        "pathway_count": 6,
        "publication_count": 89,
        "publication_id_list": "10.1074/mcp.M114.046862;10458166;10587654;10652306;10712517;10746731;11016919;11117535;11121043;11158580;11278251;11279126;11459787;11509558;11571290;11714695;11779505;1191677;11956142;12151385;12519765;12592392;12660162;12697670;12821673;12857866;15087470;15123686;1592877;16123088;16140969;16198295;16440334;16527410;16534867;16672363;1688430;17029022;17068149;1714879;17311849;17356069;1777673;17906079;18166170;18768470;18951876;24018044;24302632;25813380;26333933;29351928;29557506;29786170;30379171;30459171;3194407;32157095;3267209;32938616;32983136;33043033;33109704;34948289;35051231;3754442;3758355;38252148;38253038;38329386;38419562;38531807;38735606;6774759;7215288;7644468;7678220;7791754;8033815;8119126;8196624;8622651;8653785;8721982;8893010;9032295;9136927;9436979;9459292",
        "class_list": "",
        "function": "Activin A is a homodimer of INHBA that plays a role in several essential biological processes including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis (PubMed:3194407, PubMed:16440334). Signals through type I (such as ACVR1B or ACVR1C) and type II receptors (such as ACVR2A, ACVR2B or BMPR2) which, upon ligand binding, phosphorylate SMAD2 and SMAD3 intracellular signaling mediators that form a complex with SMAD4, translocate to the nucleus and modulate gene expression (PubMed:10652306, PubMed:24018044). Can also activate alternative non-canonical intracellular signaling pathways including the p38 MAPK, extracellular signal-regulated kinases 1/2 (ERK1/2) and c-Jun N-terminal kinases (JNKs) to modulate cell migration and differentiation (PubMed:16440334). Alternatively, promotes osteoblastic differentiation via ACVRL1-SMAD1/5/9 pathway (PubMed:34948289). In addition, can engage the type I receptor ACVR1 to form an ACVR1-activin A-type II receptor non-signaling complex (NSC) that renders receptors unavailable for engagement with BMPs, hence resulting in an apparent inhibition of ACVR1-mediated BMP signaling (PubMed:26333933)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Discovery of PELATON links to the INHBA gene in the TGF-beta pathway in colorectal cancer using a combination of bioinformatics and experimental investigations., [RefSeq, PubMed]; Elevated INHBA Promotes Tumor Progression of Cervical Cancer., [RefSeq, PubMed]; FOXA2-initiated transcriptional activation of INHBA induced by methylmalonic acid promotes pancreatic neuroendocrine neoplasm progression. Publication Status: Online-Only, [RefSeq, PubMed]; INHBA is Enriched in HPV-negative Oropharyngeal Squamous Cell Carcinoma and Promotes Cancer Progression., [RefSeq, PubMed]; Inhibin A contributes to the tumorigenesis of oral squamous cell carcinoma by KIAA1429-mediated m6A modification., [RefSeq, PubMed]; Inhibin A is a dimer of alpha/INHA and beta-A/INHBA that functions as a feedback regulator in the hypothalamic-pituitary-gonadal (HPG) axis. Inhibits the secretion of FSH from the anterior pituitary gland by acting on pituitary gonadotrope cells. Antagonizes activin A by binding to the proteoglycan, betaglycan, and forming a stable complex with and, thereby, sequestering type II activin receptors while excluding type I receptor., [UniProtKB, PubMed]; Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition., [UniProtKB, PubMed]; This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 47,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "diagnostic",
        "glycan_count": 4,
        "disease_count": 6,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14599",
        "ec_number_list": "",
        "go_molecular_function": "GO:0070699 type II activin receptor binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0005125 cytokine activity;GO:0017046 peptide hormone binding",
        "go_cellular_component": "GO:0043509 activin A complex;GO:0043512 inhibin A complex;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane",
        "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0046880 regulation of follicle-stimulating hormone secretion;GO:0046882 negative regulation of follicle-stimulating hormone secretion;GO:0060279 positive regulation of ovulation;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 9.8,
        "record_id": "P08476-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P09016-1",
        "uniprot_id": "HXD4_HUMAN",
        "mass": 27885.0,
        "length": 255,
        "protein_name": "Homeobox protein Hox-D4",
        "gene_name": "HOXD4",
        "organism": "Human",
        "refseq_name": "homeobox protein Hox-D4",
        "refseq_ac": "NP_055436",
        "gene_names_uniprotkb": "HOXD4; HOX4B",
        "gene_names_refseq": "HHO.C13; HOX-5.1; HOX4B; HOX4; HOXD4; Hox-4.2",
        "protein_names_uniprotkb": "Homeobox protein Hox-D4; Homeobox protein HHO.C13; Homeobox protein Hox-4B; Homeobox protein Hox-5.1",
        "protein_names_refseq": "Hox-4.2, mouse, homolog of homeo box X; homeobox protein HHO.C13; homeobox protein Hox-4B; homeobox protein Hox-5.1; homeobox protein Hox-D4",
        "tax_id": 9606,
        "disease": "leukemia (Disease Ontology:DOID:1240)",
        "pathway": " (hsa:3233);  (R-HSA-5617472)",
        "pathway_count": 2,
        "publication_count": 62,
        "publication_id_list": "10777502;15867264;16079151;16549775;17185360;17428788;1756725;17660710;17713478;17761849;17851529;18781158;19115252;19232136;19747919;1975088;1975093;19782034;19854132;20085832;20686522;22569366;22705304;22879880;23219899;23534758;23630040;24174538;24312487;24586203;25101834;25135475;2570724;2576652;25913784;26545093;27846572;2879245;28904123;29557506;31154438;31844290;32157095;32387766;33091337;33298915;33912179;34171305;35051231;36284347;37827698;7488013;7501971;7791786;7831296;7906964;7908827;8674428;8759021;9218805;9272954;9482740",
        "class_list": "",
        "function": "A pan-cancer analysis of the role of HOXD1, HOXD3, and HOXD4 and validation in renal cell carcinoma., [RefSeq, PubMed]; Identified heterozygous HOXD4 loss-of-function mutations in three subjects with spinal extradural arachnoid cyst (SEDAC) Publication Status: Online-Only, [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]; The results suggest that genetic polymorphisms in HOXD4 may not be a major contributor to the observed variability in peak BMD in the lumbar spine and the hip in Chinese men and women GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R9R3;Q96AU0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0048704 embryonic skeletal system morphogenesis;GO:0048568 embryonic organ development",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "P09016-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0DP01-1",
        "uniprot_id": "HV108_HUMAN",
        "mass": 12992.0,
        "length": 117,
        "protein_name": "Immunoglobulin heavy variable 1-8",
        "gene_name": "IGHV1-8",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "IGHV1-8",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 1-8",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "11340299;17576170;20176268;22158414;24600447;8490662",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "P0DP01-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P14653-1",
        "uniprot_id": "HXB1_HUMAN",
        "mass": 32193.0,
        "length": 301,
        "protein_name": "Homeobox protein Hox-B1",
        "gene_name": "HOXB1",
        "organism": "Human",
        "refseq_name": "homeobox protein Hox-B1",
        "refseq_ac": "NP_002135",
        "gene_names_uniprotkb": "HOXB1; HOX2I",
        "gene_names_refseq": "HCFP3; HOX2I; HOX2; HOXB1; Hox-2.9",
        "protein_names_uniprotkb": "Homeobox protein Hox-B1; Homeobox protein Hox-2I",
        "protein_names_refseq": "homeobox protein Hox-2I; homeobox protein Hox-B1",
        "tax_id": 9606,
        "disease": "facial paresis, hereditary congenital, 3 (MONDO:MONDO:0013880)",
        "pathway": " (hsa:3211);  (R-HSA-5617472)",
        "pathway_count": 2,
        "publication_count": 54,
        "publication_id_list": "10052460;10671062;10777502;11091361;15867264;16079151;16549775;17185360;17428788;1756725;17660710;17713478;17761849;17851529;18781158;19115252;19232136;19747919;1975088;19782034;19854132;20085832;22569366;22705304;22770981;22879880;23219899;23534758;23630040;24174538;24312487;24586203;25101834;25135475;2570724;2574852;2576652;25913784;27640920;29923154;30379171;32102121;34488545;35051231;7488013;7501971;7831296;7906964;7908827;8674428;8759021;9218805;9272954;9482740",
        "class_list": "",
        "function": "A homozygous c.74_82dup (p.Pro28delinsHisSerAlaPro) variant was identified in one individual with double outlet right ventricle (DORV). We also identified five previously reported polymorphisms (rs35114525, rs12946855, rs14534040, rs12939811, and rs7207109) in 18 patients (12 DORV and 6 perimembranous VSD). Our study did not show any pathogenic alterations in the coding region of HOXB1 among patients with VSD., [RefSeq, PubMed]; Findings revealed a novel homozygous mutation p.Arg230Trp (c.688C>T) within the HOXB1 gene of three members of a Turkish family with hereditary congenital facial paresis (HCFP3), [RefSeq, PubMed]; MicroRNA-301b-3p facilitates cell proliferation and migration in colorectal cancer by targeting HOXB1., [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures., [UniProtKB]; The results from this study demonstrate the potential of hsa-let-7g/HOXB1 axis as a therapeutic target for the treatment of lung cancer., [RefSeq, PubMed]; This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4VB03",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0019904 protein domain specific binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0007389 pattern specification process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "P14653-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P19367-1",
        "uniprot_id": "HXK1_HUMAN",
        "mass": 102486.0,
        "length": 917,
        "protein_name": "Hexokinase-1",
        "gene_name": "HK1",
        "organism": "Human",
        "refseq_name": "hexokinase-1 isoform HKI",
        "refseq_ac": "NP_000179",
        "gene_names_uniprotkb": "HK1",
        "gene_names_refseq": "CNSHA5; HK1-ta; HK1-tb; HK1-tc; HK1; HKD; HKI; HK; HMSNR; HXK1; NEDVIBA; NMSR; RP79; hexokinase",
        "protein_names_uniprotkb": "Hexokinase-1; 2.7.1.1; Brain form hexokinase; HK I; Hexokinase type I; Hexokinase-A",
        "protein_names_refseq": "Neuropathy, hereditary motor and sensory, Russe type; brain form hexokinase; glycolytic enzyme; hexokinase IR; hexokinase type I; hexokinase-1 isoform HKI; hexokinase-A",
        "tax_id": 9606,
        "disease": "maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); congenital nonspherocytic hemolytic anemia 5 (Disease Ontology:DOID:0051006); retinitis pigmentosa 79 (Disease Ontology:DOID:0061108); Charcot-Marie-Tooth disease type 4G (Disease Ontology:DOID:0110196); retinitis pigmentosa (Disease Ontology:DOID:10584); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); neonatal diabetes mellitus (Disease Ontology:DOID:11717); hyperinsulinemic hypoglycemia (Disease Ontology:DOID:13317); anemia (Disease Ontology:DOID:2355); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); glucose metabolism disease (Disease Ontology:DOID:4194); hyperglycemia (Disease Ontology:DOID:4195); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970); neurodevelopmental disorder with visual defects and brain anomalies (MONDO:MONDO:0032807)",
        "pathway": " (hsa:3098);  (R-HSA-446205);  (R-HSA-5619056);  (R-HSA-70171)",
        "pathway_count": 4,
        "publication_count": 163,
        "publication_id_list": "10.1101/2023.09.13.557529;10574795;10686099;10714828;10978502;10980531;11082198;11237011;11371164;11506403;11780755;12393545;12616532;1278465;12965206;13538944;15710582;1637300;16511037;16540464;17804405;183598;1871135;18910716;18910717;18927083;19413330;19536174;1985912;20068231;22219026;22304920;22544926;23168256;23446454;24035193;24366607;2462567;24715725;25190649;25316723;25418920;25576301;25645385;25648650;25892735;26154972;26375851;26811146;26929215;26992070;27374331;27846572;2793178;28054552;2846554;28675158;28904123;29493099;29557506;2960695;30315122;30379171;30410026;30429286;30517626;30778173;30779550;30833945;31154438;31217245;31222486;31530632;3170585;31844290;31848261;31937595;31998317;3207429;3208766;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33298915;3355497;33592498;33633747;33691108;33912179;33936100;33968037;33986552;34019948;34087483;34171305;34185709;34193129;34211107;34357683;34509645;3453121;34725712;34782236;34932366;35051231;3529090;35318648;35561310;35580925;36010968;36241641;36284347;37938771;38292764;38301092;38665916;39080798;39261628;40914422;4413246;4555506;4827367;5009693;5687724;5946626;6434534;6444721;6451249;6696436;6771269;6848140;7144574;7150652;7391027;7655856;7717389;7825568;7989588;8117307;8307007;8325892;8447317;8706938;8786021;9028305;9070917;9119384;9140401;9438414;9493266;9531504;9735292",
        "class_list": "glycogene",
        "function": "Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Expanding the Molecular Spectrum of HK1-Related Charcot-Marie-Tooth Disease, Type 4G; the First Report in Iran. Publication Status: Online-Only, [RefSeq, PubMed]; Hexokinase-linked glycolytic overload and unscheduled glycolysis in hyperglycemia-induced pathogenesis of insulin resistance, beta-cell glucotoxicity, and diabetic vascular complications. Publication Status: Online-Only, [RefSeq, PubMed]; Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific. [provided by RefSeq, Apr 2016]., [RefSeq]; MiR-34a-HK1 signal axis retards bone marrow mesenchymal stem cell senescence via ameliorating glycolytic metabolism. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 864,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 19,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PCK0;O43443;O43444;O75574;Q5VTC3;Q96HC8;Q9NNZ4;Q9NNZ5",
        "ec_number_list": "2.7.1.1;2.7.1.-",
        "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0019158 mannokinase activity;GO:0042834 peptidoglycan binding;GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0045121 membrane raft;GO:0031966 mitochondrial membrane",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0006006 glucose metabolic process;GO:0001678 intracellular glucose homeostasis;GO:0006096 glycolytic process",
        "synthesized_glycan_count": 0,
        "hit_score": 16.9,
        "record_id": "P19367-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P20719-1",
        "uniprot_id": "HXA5_HUMAN",
        "mass": 29345.0,
        "length": 270,
        "protein_name": "Homeobox protein Hox-A5",
        "gene_name": "HOXA5",
        "organism": "Human",
        "refseq_name": "homeobox protein Hox-A5",
        "refseq_ac": "NP_061975",
        "gene_names_uniprotkb": "HOXA5; HOX1C",
        "gene_names_refseq": "HOX1.3; HOX1C; HOX1; HOXA5",
        "protein_names_uniprotkb": "Homeobox protein Hox-A5; Homeobox protein Hox-1C",
        "protein_names_refseq": "homeo box 1C; homeo box A5; homeobox protein HOXA5; homeobox protein Hox-1C; homeobox protein Hox-A5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3202)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "10.1101/2023.09.13.557529;18669648;2568583;2576652;29393594;30620550;34846842;35580925;36284347;36536414;36660797;36701095;37541260;37626900;38521405;38665916;38838015;40596516;7791786;9191052",
        "class_list": "",
        "function": "CircNTNG1 inhibits renal cell carcinoma progression via HOXA5-mediated epigenetic silencing of Slug. Erratum:[Mol Cancer. 2023 Jan 20;22(1):14. doi: 10.1186/s12943-023-01726-w. PMID: 36670419] Publication Status: Online-Only, [RefSeq, PubMed]; Deregulation of miR-375 Inhibits HOXA5 and Promotes Migration, Invasion, and Cell Proliferation in Breast Cancer., [RefSeq, PubMed]; HOXA5 inhibits the proliferation and metastasis of cervical squamous cell carcinoma by suppressing the beta-catenin/Snail signaling., [RefSeq, PubMed]; Hypermethylation leads to the loss of HOXA5, resulting in JAG1 expression and NOTCH signaling contributing to kidney fibrosis., [RefSeq, PubMed]; In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008]., [RefSeq]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'., [UniProtKB]; The Transcription Factor HOXA5: Novel Insights into Metabolic Diseases and Adipose Tissue Dysfunction. Review article Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D179;O43367;Q96CY6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0043065 positive regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "P20719-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P20809-1",
        "uniprot_id": "IL11_HUMAN",
        "mass": 21429.0,
        "length": 199,
        "protein_name": "Interleukin-11",
        "gene_name": "IL11",
        "organism": "Human",
        "refseq_name": "interleukin-11 isoform 1 precursor",
        "refseq_ac": "NP_000632",
        "gene_names_uniprotkb": "IL11",
        "gene_names_refseq": "AGIF; IL-11; IL11",
        "protein_names_uniprotkb": "Interleukin-11; AGIF; Adipogenesis inhibitory factor; IL-11",
        "protein_names_refseq": "adipogenesis inhibitory factor; interleukin-11 isoform 1 precursor; oprelvekin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3589);  (R-HSA-6788467)",
        "pathway_count": 2,
        "publication_count": 42,
        "publication_id_list": "10586060;10812968;10966616;11237011;11834704;11943154;12601009;12707266;12811586;12919066;1386338;15450249;15519241;16051226;1828438;19920145;2145578;21715184;25195742;2779549;30279168;31222486;32488085;33592498;33968037;36010968;38643817;38679415;39020175;39294742;39358385;7670098;7738033;7852997;7862649;7957045;8119965;8272873;8390097;8627290;8637716;9238703",
        "class_list": "",
        "function": "Characterization of the angiomodulatory effects of Interleukin 11 cis- and trans-signaling in the retina. Publication Status: Online-Only, [RefSeq, PubMed]; Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed:30279168)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Inhibition of IL-11 signalling extends mammalian healthspan and lifespan., [RefSeq, PubMed]; Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Serum levels of IL-9 and IL-11 serve as predictors for the occurrence of early neurologic deterioration in patients with cerebral infarction., [RefSeq, PubMed]; Targeting IL-11 to reduce fibrocyte circulation and lung accumulation in animal models of pulmonary hypertension-associated lung fibrosis., [RefSeq, PubMed]; The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DQV5;Q96EB4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005142 interleukin-11 receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:0030219 megakaryocyte differentiation;GO:0060302 negative regulation of cytokine activity;GO:0008284 positive regulation of cell population proliferation;GO:0033138 positive regulation of peptidyl-serine phosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "P20809-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P42357-1",
        "uniprot_id": "HUTH_HUMAN",
        "mass": 72698.0,
        "length": 657,
        "protein_name": "Histidine ammonia-lyase",
        "gene_name": "HAL",
        "organism": "Human",
        "refseq_name": "histidine ammonia-lyase isoform 2",
        "refseq_ac": "NP_001245262",
        "gene_names_uniprotkb": "HAL; HIS",
        "gene_names_refseq": "HAL; HIS; HSTD",
        "protein_names_uniprotkb": "Histidine ammonia-lyase; 4.3.1.3; Histidase",
        "protein_names_refseq": "histidase; histidine ammonia-lyase isoform 2",
        "tax_id": 9606,
        "disease": "histidinemia (Disease Ontology:DOID:0060168)",
        "pathway": " (hsa:3034);  (R-HSA-70921)",
        "pathway_count": 2,
        "publication_count": 37,
        "publication_id_list": "10773664;11237011;11566133;12072962;12815595;1425659;15221005;15741241;15806399;18154359;19304569;20097752;25575548;26001783;26374642;26992070;28832583;29557506;30397120;31154438;31435991;31844290;32387766;32983136;33141586;33392160;34171305;34509645;35051231;36215666;36284347;36862244;38665916;7901203;7916645;7943261;8530107",
        "class_list": "",
        "function": "Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]., [RefSeq]; In the analysis of the genotype tissue expression (GTEx) project datasets, HAL rs17676826 C and NOXRED1 rs8012548 G alleles were significantly associated with their mRNA expression levels in sun-exposed skin of the lower leg (P = 6.62 x 10(-6) and 1.37 x 10(-7) , respectively) and in sun-not-exposed suprapubic skin (P < .001 and 1.43 x 10(-8) , respectively)., [RefSeq, PubMed]; The role of single nucleotide variant rs3819817 of the Histidine Ammonia-Lyase gene and 25-Hydroxyvitamin D on bone mineral density, adiposity markers, and skin pigmentation, in Mexican population., [RefSeq, PubMed]; This evidence supports that the Hal gene is turned on by glucocorticoids and by glucagon either via PKC or PKA, but prefers the PKA pathway., [RefSeq, PubMed]; This report describes the first mutations occurring in the coding region of the histidase structural gene in patients with histidinemia. Erratum:[Hum Genet. 2005 Dec;118(3-4):531-2], [RefSeq, PubMed]; Three LoF mutations in HAL were associated with increased histidine levels, which in turn were shown to be inversely related to the risk of CHD among both African Americans and European Americans., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DQC1;B4E0V8;F5GXF2;F5H1U5;Q4VB92;Q4VB93",
        "ec_number_list": "4.3.1.3",
        "go_molecular_function": "GO:0004397 histidine ammonia-lyase activity;GO:0016841 ammonia-lyase activity;GO:0003824 catalytic activity",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0019556 L-histidine catabolic process to glutamate and formamide;GO:0019557 L-histidine catabolic process to glutamate and formate;GO:0006548 L-histidine catabolic process;GO:0006547 L-histidine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "P42357-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P48735-1",
        "uniprot_id": "IDHP_HUMAN",
        "mass": 50909.0,
        "length": 452,
        "protein_name": "Isocitrate dehydrogenase [NADP], mitochondrial",
        "gene_name": "IDH2",
        "organism": "Human",
        "refseq_name": "isocitrate dehydrogenase [NADP], mitochondrial isoform 2",
        "refseq_ac": "NP_001276839",
        "gene_names_uniprotkb": "IDH2",
        "gene_names_refseq": "D2HGA2; ICD-M; IDH-2; IDH2; IDHM; IDH; IDPM; IDP; mNADP-IDH",
        "protein_names_uniprotkb": "Isocitrate dehydrogenase [NADP], mitochondrial; 1.1.1.42; ICD-M; IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase",
        "protein_names_refseq": "NADP(+)-specific ICDH; isocitrate dehydrogenase (NADP(+)) 2, mitochondrial; isocitrate dehydrogenase 2 (NADP+), mitochondrial; isocitrate dehydrogenase [NADP], mitochondrial isoform 2; oxalosuccinate decarboxylase",
        "tax_id": 9606,
        "disease": "bone remodeling disease (Disease Ontology:DOID:0080005); D-2-hydroxyglutaric aciduria 2 (Disease Ontology:DOID:0111352); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); status epilepticus (Disease Ontology:DOID:1824); high grade glioma (Disease Ontology:DOID:3070); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); hepatocellular clear cell carcinoma (Disease Ontology:DOID:5016); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119)",
        "pathway": " (hsa:3418);  (R-HSA-2151201);  (R-HSA-71403);  (R-HSA-9837999);  (R-HSA-9854311)",
        "pathway_count": 5,
        "publication_count": 188,
        "publication_id_list": "10412986;1052766;10643692;10673423;10713165;10727444;11237011;11278619;11340167;11809803;11923310;12198491;12207025;12374852;12563009;12745923;13181903;14249115;14555658;14623864;14832224;14946179;15234968;15247478;15522782;15652751;15684387;15870080;15877282;15987702;16079181;16079853;16115876;16143825;16737955;16740313;16788062;16890199;16908542;16911507;17031457;17101804;17182618;17297443;17432878;17437997;17579211;17668387;17715127;17923681;18215119;18343819;18680753;18806796;18914071;19001277;19228619;19356719;19417006;1946331;19608861;19628817;19841671;19951946;2005110;20058876;20167786;20435888;20659156;20847235;21641335;22262461;22323113;22416140;22710082;23201127;23481700;23564345;23747254;23815907;23931759;23949315;24315374;24403254;24520911;24715725;24954416;24954417;25495392;25564869;25753205;26161668;26189213;26268241;26375851;26504172;26749241;26758079;26923599;26992070;27118404;27189937;27374498;27496948;27642048;27846572;27862975;27920218;28325290;28377575;28380382;28391595;28396416;28411811;28510447;28873367;28887308;28904123;29301859;29493099;29557506;29932645;30120231;30315122;30761759;30779550;30833945;30844107;31020640;31154438;31217245;31291378;31327635;31695197;31844290;31848261;31937595;32350084;32387766;32938616;32983136;33043033;33058874;33141586;33257573;33298915;33592498;33936100;34171305;34229054;34289383;34357683;34489470;34509645;34704252;34943861;35051231;35154160;35318648;35366151;35870450;36139014;36284347;36420423;36629048;37938771;38413708;38653782;38665916;38842680;38928223;38960475;40914422;7623837;7629110;7799916;8108407;8200987;8333869;8616157;9178750;9286700;9765290;9765291;9792106;9792662;9809442;9989622",
        "class_list": "",
        "function": "Clinical and imaging characteristics of supratentorial glioma with IDH2 mutation. Erratum:[Neuroradiology. 2024 Jun;66(6):983. doi: 10.1007/s00234-024-03369-0. PMID: 38679688], [RefSeq, PubMed]; Differential isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 mutation-related landscape in intrahepatic cholangiocarcinoma., [RefSeq, PubMed]; Epigenetic dysregulation in cancers by isocitrate dehydrogenase 2 (IDH2). Review article, [RefSeq, PubMed]; Isocitrate dehydrogenase 2 regulates the proliferation of triple-negative breast cancer through the ferroptosis pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]., [RefSeq]; Methylation-Based Characterization of a New IDH2 Mutation in Sinonasal Undifferentiated Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in intermediary metabolism and energy production (PubMed:19228619, PubMed:22416140). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:19228619, PubMed:22416140)., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 14,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6L6;B4DFL2;Q96GT3",
        "ec_number_list": "2.3.3.1;7.1.1.2;1.1.1.42;3.6.4.10;1.4.1.3;1.15.1.1;1.2.1.3;7.1.2.2;4.2.1.2;1.2.4.1;1.8.1.4;5.6.1.7;2.3.1.37;4.98.1.1;1.1.1.38;2.3.1.9;1.2.1.36;1.7.1.-;1.2.1.28;1.1.1.37;5.3.3.8;3.1.2.2;1.1.1.41;2.8.3.5;3.5.3.1;1.2.4.2;1.1.1.30;5.3.3.21;2.7.11.2;2.7.11.-;3.4.21.92;1.1.1.35;6.2.1.-;6.2.1.4;4.2.1.3;6.2.1.1;6.2.1.17;2.3.1.-;2.3.1.286;2.3.1.41;1.3.8.5",
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0051287 NAD binding;GO:0004450 isocitrate dehydrogenase (NADP+) activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005777 peroxisome;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0006741 NADP+ biosynthetic process;GO:1903976 negative regulation of glial cell migration;GO:1904465 negative regulation of matrix metallopeptidase secretion;GO:0006099 tricarboxylic acid cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 19.1,
        "record_id": "P48735-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P55103-1",
        "uniprot_id": "INHBC_HUMAN",
        "mass": 38238.0,
        "length": 352,
        "protein_name": "Inhibin beta C chain",
        "gene_name": "INHBC",
        "organism": "Human",
        "refseq_name": "inhibin beta C chain preproprotein",
        "refseq_ac": "NP_005529",
        "gene_names_uniprotkb": "INHBC",
        "gene_names_refseq": "IHBC; INHBC",
        "protein_names_uniprotkb": "Inhibin beta C chain; Activin beta-C chain",
        "protein_names_refseq": "activin beta-C chain; inhibin beta C chain preproprotein; inhibin beta C chain; inhibin beta C subunit",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3626);  (R-HSA-209822)",
        "pathway_count": 2,
        "publication_count": 15,
        "publication_id_list": "1191677;16123088;16527410;1688430;23284751;23580013;24599287;25062451;28116672;30620550;35580925;6774759;7215288;7826378;9428386",
        "class_list": "",
        "function": "Activin A, B, and AB have similar effects on steroidogenesis in human granulosa cells; in contrast, activin AC is not biologically active and does not act as a competitive antagonist., [RefSeq, PubMed]; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins., [UniProtKB]; Serum inhibin levels correlate with clinical characteristics and mortality in epithelial ovarian cancer patients. Publication Status: Online-Only, [RefSeq, PubMed]; Single Nucleotide Polymorphisms in INHBC gene is associated with brain metastasis in non-small-cell lung cancer, [RefSeq, PubMed]; Study shows an up-regulation of activin-C in aggressive prostate cancer only, suggesting that activin-C may play a role in the advanced stages of the disease., [RefSeq, PubMed]; The inhibin-betaC subunit is down-regulated, while inhibin-betaE is up-regulated by interferon-beta1a in Ishikawa carcinoma cell line., [RefSeq, PubMed]; This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L3Y2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005125 cytokine activity;GO:0005160 transforming growth factor beta receptor binding;GO:0005179 hormone activity;GO:0008083 growth factor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "P55103-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P61925-1",
        "uniprot_id": "IPKA_HUMAN",
        "mass": 7989.0,
        "length": 76,
        "protein_name": "cAMP-dependent protein kinase inhibitor alpha",
        "gene_name": "PKIA",
        "organism": "Human",
        "refseq_name": "cAMP-dependent protein kinase inhibitor alpha",
        "refseq_ac": "NP_006814",
        "gene_names_uniprotkb": "PKIA; PRKACN1",
        "gene_names_refseq": "PKIA; PRKACN1",
        "protein_names_uniprotkb": "cAMP-dependent protein kinase inhibitor alpha; PKI-alpha; cAMP-dependent protein kinase inhibitor, muscle/brain isoform",
        "protein_names_refseq": "PKI-alpha; cAMP-dependent protein kinase inhibitor alpha; protein kinase (cAMP-dependent, catalytic) inhibitor alpha",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5569)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "1770951;1956339;2434500;29557506;31844290;34561969;37644544",
        "class_list": "",
        "function": "Exploring the methylation status of CFTR and PKIA genes as potential biomarkers for lung adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains., [UniProtKB]; The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P04541;Q6IAV2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:2000480 negative regulation of cAMP-dependent protein kinase activity;GO:0141162 negative regulation of cAMP/PKA signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "P61925-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P83105-1",
        "uniprot_id": "HTRA4_HUMAN",
        "mass": 50979.0,
        "length": 476,
        "protein_name": "Serine protease HTRA4",
        "gene_name": "HTRA4",
        "organism": "Human",
        "refseq_name": "serine protease HTRA4 precursor",
        "refseq_ac": "NP_710159",
        "gene_names_uniprotkb": "HTRA4",
        "gene_names_refseq": "HTRA4",
        "protein_names_uniprotkb": "Serine protease HTRA4; 3.4.21.-; High-temperature requirement factor A4",
        "protein_names_refseq": "high-temperature requirement factor A4; probable serine protease HTRA4; serine protease HTRA4 precursor",
        "tax_id": 9606,
        "disease": "Parkinson's disease (Disease Ontology:DOID:14330)",
        "pathway": " (hsa:203100)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "12408815;22778138;22964307;23481700;24715725;25002585;34087483;35051231;37296580;37579694;38325051;38880601",
        "class_list": "",
        "function": "Cellular Functions of High-Temperature Requirement Factor A4 in Placenta. Publication Status: Online-Only, [RefSeq, PubMed]; Conditioned media from these two cell lines after decidualization treatment suppress HtrA4-expressing JAR cell invasion in an HtrA1- or HtrA3-dependent manner., [RefSeq, PubMed]; Data suggest that increased HtrA4 (and HtrA1) in placenta tissues may be involved in onset of pre-eclampsia; elevated level of HtrA4 (but not HtrA1) in sera has potential as biomarker for pre-eclampsia., [RefSeq, PubMed]; Deficiency of HtrA4 in BeWo cells downregulates angiogenesis through IL-6/JAK/STAT3 signaling., [RefSeq, PubMed]; FLJ90724 or HTRA4 is a member of the HtrA family of proteases Review article, [RefSeq, PubMed]; HtrA4 is required for human trophoblast stem cell differentiation into syncytiotrophoblast., [RefSeq, PubMed]; Identification of HTRA4 as a Transcriptional Target of p63 in Trophoblast., [RefSeq, PubMed]; Serine protease., [UniProtKB]; Study reveals a novel function of GCM1 and HtrA4 in regulation of trophoblast invasion and that abnormal HrtA4 expression may contribute to shallow trophoblast invasion in preeclampsia, [RefSeq, PubMed]; This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q542Z4;Q6PF13",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0012501 programmed cell death",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "P83105-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13099-2",
        "uniprot_id": "IFT88_HUMAN",
        "mass": 93192.0,
        "length": 824,
        "protein_name": "Intraflagellar transport protein 88 homolog",
        "gene_name": "IFT88",
        "organism": "Human",
        "refseq_name": "intraflagellar transport protein 88 homolog isoform 2",
        "refseq_ac": "NP_006522",
        "gene_names_uniprotkb": "IFT88; TG737; TTC10",
        "gene_names_refseq": "D13S1056E; DAF19; IFT88; TG737; TTC10; hTg737",
        "protein_names_uniprotkb": "Intraflagellar transport protein 88 homolog; Recessive polycystic kidney disease protein Tg737 homolog; TPR repeat protein 10; Tetratricopeptide repeat protein 10",
        "protein_names_refseq": "TPR repeat protein 10; intraflagellar transport 88 homolog; intraflagellar transport protein 88 homolog isoform 2; intraflagellar transport protein 88 homolog; polaris homolog; probe hTg737 (polycystic kidney disease, autosomal recessive); recessive polycystic kidney disease protein Tg737 homolog; testicular tissue protein Li 93; tetratricopeptide repeat domain 10; tetratricopeptide repeat protein 10",
        "tax_id": 9606,
        "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); silicosis (Disease Ontology:DOID:10325); scimitar syndrome (Disease Ontology:DOID:4297); mitral valve disease (Disease Ontology:DOID:61); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)",
        "pathway": " (hsa:8100);  (R-HSA-5610787);  (R-HSA-5620924);  (R-HSA-9613829);  (R-HSA-9615710);  (R-HSA-9646399)",
        "pathway_count": 6,
        "publication_count": 175,
        "publication_id_list": "10.1101/2023.09.13.557529;10069812;10089880;10491388;10966113;11082038;11285270;11375483;12024216;12192414;12435627;12795688;14603322;14675537;15087129;15231740;15269286;15489852;15523559;15930098;15955805;16049494;16061793;16136078;16229832;16254602;16311594;16339192;16396903;16435301;16492809;16493421;16707575;16775004;16782012;17027958;17200122;17312020;17314406;17442700;17553904;17574030;17604723;17641202;17762891;17785525;17846173;17960137;18180368;18304522;18327258;18364699;18369462;18455992;18644871;18832070;18852297;19000668;19112494;19147001;19196978;19223390;19253336;19286674;19365551;19384852;19450523;19549984;19592253;19666503;19720863;19767740;19776033;19805633;19877275;19906846;19948480;19996169;20067783;20154143;20207148;20395968;20412786;20435895;20460306;20526327;20526328;20530210;20797626;20844016;20889716;20956384;2105456;21209331;21238931;21282471;21427764;21695114;21801010;21936775;22007132;2204156;22118932;22231273;22391300;22922713;22992454;23209152;23332756;23481700;23515720;23719536;23945166;23990561;24140113;24200693;24296415;24302888;24339784;24596149;24616010;24845016;24863049;24917297;24925320;24952464;25205765;25349261;25443296;25576301;25892735;25961502;26118642;26552660;27600516;27767179;2799391;28228285;28428259;28625565;28832583;29242379;29393594;29626215;29769354;30315122;30388400;32157095;32897882;32938616;32983136;33912179;33968037;33981976;34171305;34185709;34357683;34509645;35051231;35318648;35494241;35580925;36084949;39408701;7633404;8516294;8522608;8662539;9038169;9114011;9151685;9585416;9585417;9852153;9864362",
        "class_list": "",
        "function": "Multifaceted investigation underlies diverse mechanisms contributing to the downregulation of Hedgehog pathway-associated genes INTU and IFT88 in lung adenocarcinoma and uterine corpus endometrial carcinoma., [RefSeq, PubMed]; Positively regulates primary cilium biogenesis (PubMed:17604723). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment., [UniProtKB, UniProtKB, PubMed]; This gene encodes a member of the tetratrico peptide repeat (TPR) family. The encoded protein is involved in cilium biogenesis. Mutations of a similar gene in mouse can cause polycystic kidney disease. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2017]., [RefSeq]; Vinblastine Resistance Is Associated with Nephronophthisis 3-Mediated Primary Cilia via Intraflagellar Transport Protein 88 and Apoptosis-Antagonizing Transcription Factor. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 9737,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A491;B4DUS2;Q5SZJ6;Q8N719",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019894 kinesin binding",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium;GO:0031514 motile cilium;GO:0036126 sperm flagellum",
        "go_biological_process": "GO:0034021 response to silicon dioxide;GO:0001822 kidney development;GO:0060271 cilium assembly;GO:1905515 non-motile cilium assembly;GO:0042073 intraciliary transport",
        "synthesized_glycan_count": 0,
        "hit_score": 17.8,
        "record_id": "Q13099-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14568-1",
        "uniprot_id": "HS902_HUMAN",
        "mass": 39365.0,
        "length": 343,
        "protein_name": "Heat shock protein HSP 90-alpha A2",
        "gene_name": "HSP90AA2P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "HSP90AA2P; HSP90AA2; HSPC2; HSPCAL3",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Heat shock protein HSP 90-alpha A2; Heat shock 90 kDa protein 1 alpha-like 3; Heat shock protein HSP 90-alpha A2 pseudogene; Heat shock protein family C member 2",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162)",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 63,
        "publication_id_list": "10.1101/2023.09.13.557529;14978097;16269234;1740332;18318008;18663603;18991276;23783831;2591742;26154972;27452731;27543614;27600516;27920218;28063628;28218747;28228285;28446606;28514659;28832583;28834231;28855257;28904123;29192674;29242379;29314611;29331515;29393594;29508533;29557506;29632046;29632711;29786170;30315122;30397120;30524438;30626607;30779550;32157095;32897882;32938616;32983136;33298915;33592498;33691108;33717175;33912179;33936100;33968037;34087483;34171305;34509645;34561969;34932366;35051231;35154160;35251023;35318648;35561310;35580925;36010968;36241641;37217939",
        "class_list": "",
        "function": "Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0070062 extracellular exosome;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0034605 cellular response to heat;GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0022618 protein-RNA complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 6.8,
        "record_id": "Q14568-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14641-1",
        "uniprot_id": "INSL4_HUMAN",
        "mass": 15445.0,
        "length": 139,
        "protein_name": "Early placenta insulin-like peptide",
        "gene_name": "INSL4",
        "organism": "Human",
        "refseq_name": "early placenta insulin-like peptide precursor",
        "refseq_ac": "NP_002186",
        "gene_names_uniprotkb": "INSL4",
        "gene_names_refseq": "EPIL; INSL4; PLACENTIN",
        "protein_names_uniprotkb": "Early placenta insulin-like peptide; EPIL; Insulin-like peptide 4; Placentin",
        "protein_names_refseq": "early placenta insulin-like peptide (EPIL); early placenta insulin-like peptide precursor; insulin-like 4 (placenta); insulin-like peptide 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3641)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "10.1038/emboj.2013.79;12414911;15340161;15958731;18035692;23302396;23481700;23584533;24715725;30423141;33968037;8666396;9284764;9740319",
        "class_list": "",
        "function": "A tight interaction between HER-2 gene and EPIL in invasive breast cancer cells is probable., [RefSeq, PubMed]; Expression of the INSL4 gene was doubled in the placenta of the growth-restricted twin compared to the normally grown sibling, suggesting that it may be linked to a higher level of apoptosis and loss of cell viability, [RefSeq, PubMed]; INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast. [provided by RefSeq, Jul 2008]., [RefSeq]; LKB1 deficiency induces an autocrine INSL4 signaling that critically supports the growth and survival of lung cancer cells. Therefore, aberrant INSL4 signaling is a promising therapeutic target for LKB1-deficient lung cancers., [RefSeq, PubMed]; May play an important role in trophoblast development and in the regulation of bone formation., [UniProtKB]; Report decreased INSL4 gene expression in both the invasive and the noninvasive areas of villous trophoblast in patients with placenta accreta., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K678;Q5W127",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005159 insulin-like growth factor receptor binding;GO:0005179 hormone activity",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0007267 cell-cell signaling;GO:1901384 positive regulation of chorionic trophoblast cell proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q14641-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q27J81-1",
        "uniprot_id": "INF2_HUMAN",
        "mass": 135624.0,
        "length": 1249,
        "protein_name": "Inverted formin-2",
        "gene_name": "INF2",
        "organism": "Human",
        "refseq_name": "inverted formin-2 isoform 2",
        "refseq_ac": "NP_001026884",
        "gene_names_uniprotkb": "INF2; C14orf151; C14orf173",
        "gene_names_refseq": "C14orf151; C14orf173; CMTDIE; FSGS5; INF2; pp9484",
        "protein_names_uniprotkb": "Inverted formin-2; HBEBP2-binding protein C",
        "protein_names_refseq": "HBEAG-binding protein 2 binding protein C; HBEBP2-binding protein C; inverted formin, FH2 and WH2 domain containing; inverted formin-2 isoform 2",
        "tax_id": 9606,
        "disease": "glomerulosclerosis (Disease Ontology:DOID:0050851); Charcot-Marie-Tooth disease dominant intermediate E (Disease Ontology:DOID:0110205); focal segmental glomerulosclerosis 5 (Disease Ontology:DOID:0111130)",
        "pathway": " (hsa:64423)",
        "pathway_count": 1,
        "publication_count": 104,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;17081983;18318008;18452278;18510355;18669648;19651622;19690332;19691289;20023659;20068231;20166139;20803156;21258034;21406692;21866090;22187985;22971997;23014460;23186163;23301498;23783831;24174593;24275569;24715725;24750328;25165188;25576301;25645385;25676889;26154972;26992070;27452731;27600516;27846572;28218747;28228285;28510447;28832583;28834231;28904123;29242379;29393594;29493099;29557506;29769354;29786170;30192525;30315122;30429286;30524438;30779550;30833945;31092671;31154438;31222486;31373491;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33232676;33298915;33465208;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34509645;34561969;34725712;34932366;35051231;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37344480;37938771;38233384;38253038;38270181;38665916;38843827;38916773",
        "class_list": "",
        "function": "FBXO7, a tumor suppressor in endometrial carcinoma, suppresses INF2-associated mitochondrial division. Publication Status: Online-Only, [RefSeq, PubMed]; Functional genetic variants of the disulfidptosis-related INF2 gene predict survival of hepatitis B virus-related hepatocellular carcinoma., [RefSeq, PubMed]; INF2 formin variants linked to human inherited kidney disease reprogram the transcriptome, causing mitotic chaos and cell death. Publication Status: Online-Only, [RefSeq, PubMed]; In conclusion, we described an additional familial case of the autosomal dominant form of focalsegmental glomerulosclerosis associated with INF2 mutations., [RefSeq, PubMed]; Mechanisms of actin filament severing and elongation by formins., [RefSeq, PubMed]; Phosphorylation of INF2 by AMPK promotes mitochondrial fission and oncogenic function in endometrial cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Severs actin filaments and accelerates their polymerization and depolymerization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Six of the seven distinct altered residues localized to an INF2 region that corresponded to a subdomain of the mDia1 diaphanous inhibitory domain reported to co-immunoprecipitate with IQ motif-containing GTPase-activating protein 1, [RefSeq, PubMed]; Study identified nine independent nonconservative missense mutations in INF2, which encodes a member of the formin family of actin-regulating proteins. Erratum:[Nat Genet. 2010 Apr;42(4):361. Tonna, Stephen J [added]], [RefSeq, PubMed]; This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.[provided by RefSeq, Aug 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 24,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q27J83;Q69YL8;Q6P1X7;Q6PK22;Q86TR7;Q9BRM1;Q9H6N1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005884 actin filament;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0090140 regulation of mitochondrial fission;GO:0030041 actin filament polymerization;GO:0030036 actin cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 11.1,
        "record_id": "Q27J81-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q53G44-1",
        "uniprot_id": "IF44L_HUMAN",
        "mass": 51322.0,
        "length": 452,
        "protein_name": "Interferon-induced protein 44-like",
        "gene_name": "IFI44L",
        "organism": "Human",
        "refseq_name": "interferon-induced protein 44-like isoform 1",
        "refseq_ac": "NP_006811",
        "gene_names_uniprotkb": "IFI44L; C1orf29; GS3686",
        "gene_names_refseq": "C1orf29; GS3686; IFI44L; TLDC5B",
        "protein_names_uniprotkb": "Interferon-induced protein 44-like",
        "protein_names_refseq": "interferon-induced protein 44-like isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10964);  (R-HSA-9909505)",
        "pathway_count": 2,
        "publication_count": 60,
        "publication_id_list": "11237011;18057259;20237496;21478870;22424782;23481700;23783831;24714562;24755989;25418920;25576301;25880248;25892735;26101251;26154972;27846572;27920218;28063628;28228285;28514659;28832583;28904123;29242379;29493099;29557506;29632046;29769354;30169894;30224801;30315122;30620550;31092671;31154438;31434731;31455651;31844290;32350084;32357974;32502341;32611756;32938616;32983136;33298915;33691108;33717175;33912179;34357683;34722780;34932366;35051231;35580925;35592687;36284347;36584854;36607476;36793726;36893516;37938771;38989827;39531497",
        "class_list": "",
        "function": "ACSL4 upregulates IFI44 and IFI44L expression and promotes the proliferation and invasiveness of head and neck squamous cell carcinoma cells., [RefSeq, PubMed]; Epigenetic Regulation of IFI44L Expression in Monocytes Affects the Functions of Monocyte-Derived Dendritic Cells in Systemic Lupus Erythematosus. Publication Status: Online-Only, [RefSeq, PubMed]; IFI44L as a novel epigenetic silencing tumor suppressor promotes apoptosis through JAK/STAT1 pathway during lung carcinogenesis., [RefSeq, PubMed]; LMKB is the first protein identified to date that interacts with this portion of Ge-1. LMKB was expressed in human B and T lymphocyte cell lines; depletion of LMKB increased expression of IFI44L. Publication Status: Online-Only, [RefSeq, PubMed]; Novel polymorphism of IFI44L associated with the susceptibility and clinical characteristics of systemic lupus erythematosus in a Chinese population., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Reciprocal expression of the immune response genes CXCR3 and IFI44L as module hubs are associated with patient survivals in primary central nervous system lymphoma., [RefSeq, PubMed]; Type I interferon-stimulated gene (ISG) that plays a critical role in antiviral and antibacterial activity (PubMed:34722780). During bacterial infection, promotes macrophage differentiation and facilitates inflammatory cytokine secretion (PubMed:34722780). Plays a role in the control of respiratory syncytial virus/RSV infection, reducing the ability of the virus to replicate (PubMed:32611756). Exhibits a low antiviral activity against hepatitis C virus (PubMed:21478870). Also acts as a feedback regulator of IFN responses by negatively regulating IKBKB and IKBKE kinase activities through interaction with FKBP5 (PubMed:31434731)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86TE1;Q96B64;Q99984",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0006955 immune response;GO:0051607 defense response to virus",
        "synthesized_glycan_count": 0,
        "hit_score": 6.4,
        "record_id": "Q53G44-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6WRI0-1",
        "uniprot_id": "IGS10_HUMAN",
        "mass": 290838.0,
        "length": 2623,
        "protein_name": "Immunoglobulin superfamily member 10",
        "gene_name": "IGSF10",
        "organism": "Human",
        "refseq_name": "immunoglobulin superfamily member 10 isoform 2",
        "refseq_ac": "NP_001171617",
        "gene_names_uniprotkb": "IGSF10; CMF608",
        "gene_names_refseq": "CMF608; IGSF10",
        "protein_names_uniprotkb": "Immunoglobulin superfamily member 10; CMF608; Calvaria mechanical force protein 608; IgSF10",
        "protein_names_refseq": "calvaria mechanical force protein 608; immunoglobulin superfamily member 10 isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:285313)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;11237011;14962803;18767875;23584533;24715725;26154972;26992070;27137492;28411811;29557506;30459171;31844290;32350084;32387766;32612575;32897882;33392160;33592498;33968037;34357683;35051231;35251023;35289036;35318648;35580925;36010968;36241641;37074911;37340703;38253038;38622980",
        "class_list": "",
        "function": "IGSF10 inhibits the metastasis of lung adenocarcinoma via the Spi-B/Integrin-beta1 signaling pathway., [RefSeq, PubMed]; Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons) (By similarity). May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; SEMA3A and IGSF10 Are Novel Contributors to Combined Pituitary Hormone Deficiency (CPHD). Publication Status: Online-Only, [RefSeq, PubMed]; These data strongly suggest that mutations in IGSF10 cause delayed puberty in humans, and points to a common genetic basis for conditions of functional hypogonadotropic hypogonadism (HH). Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 6,
        "reported_o_glycosites_with_glycan": 9,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 9,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 9,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 147,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 0,
        "glyco_site_count": 22,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86YJ9;Q8N772;Q8NA84",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0030154 cell differentiation;GO:0001503 ossification;GO:2001222 regulation of neuron migration",
        "synthesized_glycan_count": 0,
        "hit_score": 5.7,
        "record_id": "Q6WRI0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N6C5-1",
        "uniprot_id": "IGSF1_HUMAN",
        "mass": 148936.0,
        "length": 1336,
        "protein_name": "Immunoglobulin superfamily member 1",
        "gene_name": "IGSF1",
        "organism": "Human",
        "refseq_name": "immunoglobulin superfamily member 1 isoform 4 precursor",
        "refseq_ac": "NP_001164433",
        "gene_names_uniprotkb": "IGSF1; IGDC1; KIAA0364; PGSF2",
        "gene_names_refseq": "CHTE; IGCD1; IGDC1; IGSF1; INHBP; PGSF2; p120",
        "protein_names_uniprotkb": "Immunoglobulin superfamily member 1; IgSF1; Immunoglobulin-like domain-containing protein 1; InhBP; Inhibin-binding protein; Pituitary gland-specific factor 2; p120",
        "protein_names_refseq": "immunoglobulin superfamily member 1 isoform 4 precursor; immunoglobulin-like domain-containing protein 1; inhibin-binding protein; pituitary gland-specific factor 2",
        "tax_id": 9606,
        "disease": "IGSF1 deficiency syndrome (Disease Ontology:DOID:0111140)",
        "pathway": " (hsa:3547)",
        "pathway_count": 1,
        "publication_count": 30,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11266516;11854097;12385827;12421765;23090970;23092983;23143598;24190977;24366607;29557506;29789417;31530632;31844290;32350084;34433824;35051231;35350016;35456429;35494241;36201163;36241641;36464600;36854408;37074911;38253038;39531497;9521868;9729118",
        "class_list": "",
        "function": "Case Report: A Detailed Phenotypic Description of Patients and Relatives with Combined Central Hypothyroidism and Growth Hormone Deficiency Carrying IGSF1 Mutations. Publication Status: Online-Only, [RefSeq, PubMed]; Congenital Central Hypothyroidism Caused by a Novel IGSF1 Variant Identified in a French Family., [RefSeq, PubMed]; IGSF1 mutation as a cause of isolated central hypothyroidism., [RefSeq, PubMed]; IGSF1 mutations are the most frequent genetic aetiology of thyrotropin deficiency. Publication Status: Online-Only, [RefSeq, PubMed]; Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription., [UniProtKB, PubMed]; This gene encodes a member of the immunoglobulin-like domain-containing superfamily. Proteins in this superfamily contain varying numbers of immunoglobulin-like domains and are thought to participate in the regulation of interactions between cells. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]., [RefSeq]; [Clinical characteristics and genetic analysis of four patients with central hypothyroidism due to IGSF1 gene variants]., [RefSeq, PubMed]",
        "predicted_glycosites": 14,
        "predicted_n_glycosites": 12,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 50,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 1,
        "glyco_site_count": 19,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5MEG2;H9KV64;O15070;Q9NTC8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0038102 activin receptor antagonist activity;GO:0004888 transmembrane signaling receptor activity;GO:0034711 inhibin binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0006355 regulation of DNA-templated transcription;GO:0032926 negative regulation of activin receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q8N6C5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N9C0-1",
        "uniprot_id": "IGS22_HUMAN",
        "mass": 100400.0,
        "length": 903,
        "protein_name": "Immunoglobulin superfamily member 22",
        "gene_name": "IGSF22",
        "organism": "Human",
        "refseq_name": "immunoglobulin superfamily member 22",
        "refseq_ac": "NP_775859",
        "gene_names_uniprotkb": "IGSF22",
        "gene_names_refseq": "IGFN2; IGSF22",
        "protein_names_uniprotkb": "Immunoglobulin superfamily member 22; IgSF22",
        "protein_names_refseq": "immunoglobulin superfamily member 22",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283284)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "21248752;28411811;29557506;33968037;35051231;35494241;39894887",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NNA0;D6RGV7",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q8N9C0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WWX8-1",
        "uniprot_id": "SC5AB_HUMAN",
        "mass": 74036.0,
        "length": 675,
        "protein_name": "Sodium/myo-inositol cotransporter 2",
        "gene_name": "SLC5A11",
        "organism": "Human",
        "refseq_name": "sodium/myo-inositol cotransporter 2 isoform 2",
        "refseq_ac": "NP_001245340",
        "gene_names_uniprotkb": "SLC5A11; KST1; SLGTX; SMIT2",
        "gene_names_refseq": "KST1; RKST1; SGLT6; SLC5A11; SMIT2",
        "protein_names_uniprotkb": "Sodium/myo-inositol cotransporter 2; Na(+)/myo-inositol cotransporter 2; SMIT2; Sodium-dependent glucose cotransporter; Sodium/glucose cotransporter KST1; Sodium/myo-inositol transporter 2; Solute carrier family 5 member 11",
        "protein_names_refseq": "Na(+)/myo-inositol cotransporter 2; homolog of rabbit KST1; putative sodium-coupled cotransporter RKST1; sodium-dependent glucose cotransporter; sodium/glucose cotransporter KST1; sodium/myo-inositol cotransporter 2 isoform 2; sodium/myo-inositol cotransporter 2; sodium/myo-inositol transporter 2; solute carrier family 5 (sodium/glucose cotransporter), member 11; solute carrier family 5 (sodium/inositol cotransporter), member 11",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:115584);  (R-HSA-429593)",
        "pathway_count": 2,
        "publication_count": 17,
        "publication_id_list": "11237011;11500374;12039040;15172003;18069935;19032932;23481700;24715725;28904123;29557506;30459171;31530632;34321228;35051231;7537337;7789985;8626564",
        "class_list": "",
        "function": "Cotransporters, such as SLC5A11, represent a major class of proteins that make use of ion gradients to drive active transport for the cellular accumulation of nutrients, neurotransmitters, osmolytes, and ions Roll et al. (2002) [PubMed 12039040].[supplied by OMIM, Mar 2008]., [RefSeq]; Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1 (PubMed:15172003, PubMed:19032932). Exclusively responsible for apical MI transport and absorption in intestine (By similarity). Can also transport D-chiro-inositol (DCI) but not L-fucose (PubMed:15172003, PubMed:19032932). Exhibits stereospecific cotransport of both D-glucose and D-xylose (By similarity). May induce apoptosis through the TNF, PDCD1 pathway (PubMed:15172003, PubMed:18069935). May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]; SLC5A11 is involved with some immune effects and interacts with immune-related gene(s); it is consistent with its function as an autoimmune modifier gene. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z329;Q05BF1;Q6PF02;Q6ZUW3;Q86Y55;Q96PP5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0015293 symporter activity;GO:0015166 polyol transmembrane transporter activity;GO:0005365 myo-inositol transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0006915 apoptotic process;GO:0006814 sodium ion transport;GO:0015798 myo-inositol transport",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q8WWX8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WYA0-1",
        "uniprot_id": "IFT81_HUMAN",
        "mass": 79746.0,
        "length": 676,
        "protein_name": "Intraflagellar transport protein 81 homolog",
        "gene_name": "IFT81",
        "organism": "Human",
        "refseq_name": "intraflagellar transport protein 81 homolog isoform 1",
        "refseq_ac": "NP_001137251",
        "gene_names_uniprotkb": "IFT81; CDV1",
        "gene_names_refseq": "CDV-1R; CDV-1; CDV1R; CDV1; DV1; IFT81; SRTD19",
        "protein_names_uniprotkb": "Intraflagellar transport protein 81 homolog; CDV-1; Carnitine deficiency-associated protein expressed in ventricle 1",
        "protein_names_refseq": "carnitine deficiency-associated gene expressed in ventricle 1; carnitine deficiency-associated protein expressed in ventricle 1; intraflagellar transport protein 81 homolog isoform 1; intraflagellar transport protein 81 homolog",
        "tax_id": 9606,
        "disease": "short-rib thoracic dysplasia 19 with or without polydactyly (Disease Ontology:DOID:0080295)",
        "pathway": " (hsa:28981);  (R-HSA-5620924)",
        "pathway_count": 2,
        "publication_count": 118,
        "publication_id_list": "10069812;11130971;11237011;11285270;12549821;12795688;15231740;15269286;15489852;15523559;15955805;16049494;16435301;16492809;16775004;16782012;17312020;17314406;17574030;18088087;18180368;18304522;18364699;18369462;18767875;18852297;19112494;19147001;19253336;19384852;19450523;19664994;19720863;19805633;20435895;20526327;20526328;20530210;20889716;21427764;21936775;22118932;22424782;22922713;22992454;23481700;23945166;23990561;24140113;24296415;24596149;24616010;24714562;25205765;25349261;25443296;25576301;25645385;25880248;26154972;26768311;26992070;27600516;27666822;27920218;28063628;28428259;28625565;28649982;28832583;28834231;28904123;29393594;29557506;29632046;29632711;30315122;30429286;30779550;30833945;31154438;31530632;31844290;31848261;31937595;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;33141586;33298915;33592498;33936100;33968037;33981976;34087483;34171305;34211107;34405274;34509645;34888642;34932366;35051231;35561310;36010968;36215666;36241641;36284347;8516294;8522608;9114011;9585416;9585417;9852153",
        "class_list": "",
        "function": "Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region (PubMed:23990561). Required for ciliogenesis (PubMed:23990561, PubMed:27666822). Required for proper regulation of SHH signaling (PubMed:27666822). Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Impaired cooperation between IFT74/BBS22-IFT81 and IFT25-IFT27/BBS19 causes Bardet-Biedl syndrome., [RefSeq, PubMed]; Inconsistent expression levels of human CDV-1 and mouse Cdv-1 in heart implied that cardiac hypertrophy in human SCD might not be associated with the abnormal expression of CDV-1, [RefSeq, PubMed]; The protein encoded by this gene, together with IFT74, forms a tubulin-binding module of intraflagellar transport complex B. This module is involved in transport of tubulin within the cilium, and the encoded protein is required for ciliogenesis. Mutations in this gene are a cause of short-rib polydactyly syndromes. [provided by RefSeq, Dec 2016]., [RefSeq]; This study found that the two core intraflagellar transport proteins IFT74 and IFT81 form a tubulin-binding module and mapped the interaction to a calponin homology domain of IFT81 and a highly basic domain in IFT74., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2YDY1;Q8NB51;Q9BSV2;Q9UNY8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0015631 tubulin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005929 cilium;GO:0031514 motile cilium;GO:0005814 centriole",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0060271 cilium assembly;GO:0008589 regulation of smoothened signaling pathway;GO:0035735 intraciliary transport involved in cilium assembly;GO:0042073 intraciliary transport",
        "synthesized_glycan_count": 0,
        "hit_score": 11.9,
        "record_id": "Q8WYA0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92826-1",
        "uniprot_id": "HXB13_HUMAN",
        "mass": 30676.0,
        "length": 284,
        "protein_name": "Homeobox protein Hox-B13",
        "gene_name": "HOXB13",
        "organism": "Human",
        "refseq_name": "homeobox protein Hox-B13",
        "refseq_ac": "NP_006352",
        "gene_names_uniprotkb": "HOXB13",
        "gene_names_refseq": "HOXB13; HPC9; PSGD",
        "protein_names_uniprotkb": "Homeobox protein Hox-B13",
        "protein_names_refseq": "homeobox protein Hox-B13",
        "tax_id": 9606,
        "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate cancer (Disease Ontology:DOID:10283); endometrial cancer (Disease Ontology:DOID:1380); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450)",
        "pathway": " (hsa:10481)",
        "pathway_count": 1,
        "publication_count": 40,
        "publication_id_list": "11857506;12761847;22236224;22714738;22718278;22781434;22841674;23036981;23064873;23099437;23129385;23141226;23292082;23312158;23334858;23393222;23396964;23457453;23518396;24026887;24148311;24310616;24722062;25595936;25629170;26108461;26779768;27424772;27626483;28186998;28473536;29259341;37409967;37552455;37806842;37850574;38792899;39534244;8756292;9665387",
        "class_list": "",
        "function": "A Comprehensive Analysis of HOXB13 Expression in Hepatocellular Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Characterization of HOXB13 expression patterns in localized and metastatic castration-resistant prostate cancer., [RefSeq, PubMed]; Clinical and Functional Analyses of an African-ancestry Gain-of-function HOXB13 Variant Implicated in Aggressive Prostate Cancer., [RefSeq, PubMed]; Epidermal HOXB13 signal was detected over the entire body surface, but surprisingly, essentially all of the signal was cytoplasmic in developing skin., [RefSeq, PubMed]; Hierarchical Phosphorylation of HOXB13 by mTOR Dictates Its Activity and Oncogenic Function in Prostate Cancer., [RefSeq, PubMed]; Immunoreactivity of HOXB13 in Neuroendocrine Neoplasms Is a Sensitive and Specific Marker of Rectal Well-Differentiated Neuroendocrine Tumors., [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (PubMed:28473536)., [UniProtKB, PubMed]; This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 40,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R878;Q96QM4;Q99810",
        "ec_number_list": "",
        "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0008327 methyl-CpG binding;GO:0043565 sequence-specific DNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008544 epidermis development",
        "synthesized_glycan_count": 0,
        "hit_score": 4.4,
        "record_id": "Q92826-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q969P0-1",
        "uniprot_id": "IGSF8_HUMAN",
        "mass": 65034.0,
        "length": 613,
        "protein_name": "Immunoglobulin superfamily member 8",
        "gene_name": "IGSF8",
        "organism": "Human",
        "refseq_name": "immunoglobulin superfamily member 8 precursor",
        "refseq_ac": "NP_001193594",
        "gene_names_uniprotkb": "IGSF8; CD81P3; EWI2; KCT4",
        "gene_names_refseq": "CD316; CD81P3; EWI-2; EWI2; IGSF8; KCT-4; LIR-D1; PGRL",
        "protein_names_uniprotkb": "Immunoglobulin superfamily member 8; CD81 partner 3; EWI-2; Glu-Trp-Ile EWI motif-containing protein 2; IgSF8; KCT-4; Keratinocytes-associated transmembrane protein 4; LIR-D1; PGRL; Prostaglandin regulatory-like protein",
        "protein_names_refseq": "CD81 partner 3; glu-Trp-Ile EWI motif-containing protein 2; immunoglobulin superfamily member 8 precursor; keratinocytes-associated transmembrane protein 4; prostaglandin regulatory-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:93185)",
        "pathway_count": 1,
        "publication_count": 60,
        "publication_id_list": "10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;11237011;11504738;12708969;12750295;12752121;14662754;15070678;17785435;19159218;19892738;21654843;22689882;23090970;23351194;23719902;24190977;24275569;25502872;25645385;25813380;25880248;26375851;26768311;27600516;28352266;28467828;28832583;28871256;28904123;29242379;29493099;29557506;29632711;29741879;31611695;31757023;31844290;32157095;32350084;32357974;32502341;32983136;33592498;33912179;33968037;33981976;34357683;34433824;35051231;35154160;35251023;35339615;35773608;36010968;36788350;37074911;38657602;40307207",
        "class_list": "",
        "function": "EWI-2-dependent reorganization of alpha4beta1-CD81 complexes on the cell surface is responsible for EWI-2 effects on integrin-dependent morphology and motility functions, [RefSeq, PubMed]; EWI2 and its relatives in Tetraspanin-enriched membrane domains regulate malignancy. Review article, [RefSeq, PubMed]; EWI2 prevents EGFR from clustering and endocytosis to reduce tumor cell movement and proliferation. Publication Status: Online-Only, [RefSeq, PubMed]; EWI2 promotes endolysosome-mediated turnover of growth factor receptors and integrins to suppress lung cancer., [RefSeq, PubMed]; EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells., [RefSeq, PubMed]; IGSF8 is an innate immune checkpoint and cancer immunotherapy target., [RefSeq, PubMed]; Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity (PubMed:11504738, PubMed:14662754). Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities (PubMed:17785435). In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation (PubMed:22689882). Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry (PubMed:23351194). Accumulates at the presynaptic terminal, the producer cell side of the virological synapse, to prevent HIV-1 Env-mediated cell-cell fusion (PubMed:31757023). Highly expressed on malignant cells with antigen presentation defects, interacts with NK receptor KIR3DL2 to suppress NK-cell cytotoxicity (PubMed:38657602). May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 37,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NG09;Q96DP4;Q9BTG9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0042734 presynaptic membrane;GO:0098686 hippocampal mossy fiber to CA3 synapse",
        "go_biological_process": "GO:0007399 nervous system development;GO:0030335 positive regulation of cell migration;GO:0007338 single fertilization;GO:0048870 cell motility;GO:0007519 skeletal muscle tissue development",
        "synthesized_glycan_count": 0,
        "hit_score": 10.2,
        "record_id": "Q969P0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96D96-1",
        "uniprot_id": "HVCN1_HUMAN",
        "mass": 31683.0,
        "length": 273,
        "protein_name": "Voltage-gated hydrogen channel 1",
        "gene_name": "HVCN1",
        "organism": "Human",
        "refseq_name": "voltage-gated hydrogen channel 1 isoform 1",
        "refseq_ac": "NP_001035196",
        "gene_names_uniprotkb": "HVCN1; PRO1140; VSOP",
        "gene_names_refseq": "HV1; HVCN1; VSOP",
        "protein_names_uniprotkb": "Voltage-gated hydrogen channel 1; HV1; Hydrogen voltage-gated channel 1; Voltage sensor domain-only protein",
        "protein_names_refseq": "voltage sensor domain-only protein; voltage-gated hydrogen channel 1 isoform 1; voltage-gated hydrogen channel 1",
        "tax_id": 9606,
        "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)",
        "pathway": " (hsa:84329);  (R-HSA-1222556);  (R-HSA-1300642);  (R-HSA-6798695)",
        "pathway_count": 4,
        "publication_count": 72,
        "publication_id_list": "10029572;11237011;11237855;11595941;11970843;12975309;16554753;17227845;17460039;17662945;17948262;19089323;19901323;20037153;20134026;20144758;20147290;20548053;20648059;21124855;21412338;21412339;22020278;23530196;23650620;24415791;24714562;24715725;25418920;25502872;27859356;27920218;28218747;28228285;2825632;2848506;28871256;28904123;29242379;29314611;29437277;29557506;29632711;29769354;30478045;31844290;32350084;32502341;32983136;33043033;33141586;33717175;33936100;33968037;34158477;34211107;34357683;34932366;35051231;35154160;35251023;35561310;36241641;37315791;37669933;38272234;39259593;40914422;7980580;8537108;8692836;9452476",
        "class_list": "",
        "function": "Arachidonic acid reverses cholesterol and zinc inhibition of human voltage-gated proton channels., [RefSeq, PubMed]; Data presented here identify H(v)1 as a long-sought voltage-gated H+ channel and establish H(v)1 as the founding member of a family of mammalian VSD proteins, [RefSeq, PubMed]; Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils. Publication Status: Online-Only, [RefSeq, PubMed]; Quantitative insights into the mechanism of proton conduction and selectivity for the human voltage-gated proton channel Hv1., [RefSeq, PubMed]; This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]., [RefSeq]; Trp207 regulation of voltage-dependent activation of human Hv1 proton channel., [RefSeq, PubMed]; Voltage-gated proton-selective channel that conducts outward proton currents in response to intracellular acidification. Lacks a canonical ion-channel pore domain and mediates proton permeability via its voltage sensor domain (PubMed:16554753, PubMed:20037153, PubMed:20548053, PubMed:22020278, PubMed:27859356, PubMed:30478045, PubMed:37669933). Appears to play a dominant role in regulation of CO2/HCO3(-)/H(+) equilibrium in sperm flagellum. Prevents the acidification resulting from HCO3(-) synthesis and thus sustains high HCO3(-) levels inside sperm for capacitation (PubMed:20144758, PubMed:30478045, PubMed:37669933). Provides for proton efflux that compensates for electron charge generated by NADPH oxidase activity either in the extracellular or phagosomal compartments, thus enabling the production of high levels of bactericidal reactive oxygen species during the respiratory burst (PubMed:20037153, PubMed:30478045). Opens when the pH of airway surface liquid exceeds 7 and contributes to respiratory epithelial acid secretion to maintain pH in the mucosa (PubMed:20548053)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; We cloned a new B cell-specific tetraspanning (BTS) membrane molecule, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MQ37;B4DEB3;F8WCH5;Q6UW11;Q96IS5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0030171 voltage-gated proton channel activity;GO:0022843 voltage-gated monoatomic cation channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0035579 specific granule membrane;GO:0016324 apical plasma membrane;GO:0030667 secretory granule membrane",
        "go_biological_process": "GO:0010043 response to zinc ion;GO:0045087 innate immune response;GO:0007338 single fertilization;GO:0009268 response to pH;GO:0045454 cell redox homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "Q96D96-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96EL1-1",
        "uniprot_id": "INKA1_HUMAN",
        "mass": 31574.0,
        "length": 287,
        "protein_name": "PAK4-inhibitor INKA1",
        "gene_name": "INKA1",
        "organism": "Human",
        "refseq_name": "PAK4-inhibitor INKA1 isoform 1",
        "refseq_ac": "NP_976248",
        "gene_names_uniprotkb": "INKA1; C3orf54; FAM212A",
        "gene_names_refseq": "C3orf54; FAM212A; INCA; INKA1",
        "protein_names_uniprotkb": "PAK4-inhibitor INKA1; Inca; Induced in neural crest by AP2-alpha protein homolog; Inka-box actin regulator 1",
        "protein_names_refseq": "HInca; Induced in Neural Crest by AP-2alpha; PAK4-inhibitor INKA1 isoform 1; PAK4-inhibitor INKA1; family with sequence similarity 212 member A; induced in neural crest by AP2-alpha protein homolog; protein FAM212A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:389119)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11237011;17314132;26607847;30796022;31844290;32502341",
        "class_list": "",
        "function": "A competitive in vivo gain-of-function screen identifies C3orf54/INKA1 as a gene regulating leukemia stem cells (LSCs) repopulation kinetics. INKA1 overexpression stalls LSC transiently in G0 without abolishing regenerative potential; silencing has the opposite effect., [RefSeq, PubMed]; Inhibitor of the serine/threonine-protein kinase PAK4 (PubMed:26607847). Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity (PubMed:26607847)., [UniProtKB, PubMed]; Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity., [UniProtKB, UniProtKB]; Inka1 is an endogenous inhibitor of PAK4 that binds to the catalytic domain and forms crystals with PAK4 in cells. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030291 protein serine/threonine kinase inhibitor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q96EL1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96ID5-1",
        "uniprot_id": "IGS21_HUMAN",
        "mass": 51835.0,
        "length": 467,
        "protein_name": "Immunoglobulin superfamily member 21",
        "gene_name": "IGSF21",
        "organism": "Human",
        "refseq_name": "immunoglobulin superfamily member 21 precursor",
        "refseq_ac": "NP_116269",
        "gene_names_uniprotkb": "IGSF21",
        "gene_names_refseq": "IGSF21",
        "protein_names_uniprotkb": "Immunoglobulin superfamily member 21; IgSF21",
        "protein_names_refseq": "immunoglobulin superfamily member 21 precursor; immunoglobulin superfamily member 21",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84966)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "16303743;16959974;19240061;27607899;28411811;29557506;30429286;35051231",
        "class_list": "",
        "function": "Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2., [UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Results suggest that LEKR1-CCNL1 and IGSF21-KLHDC7A gene polymorphisms influence the development of diabetic retinopathy (DR)., [RefSeq, PubMed]; This gene encodes a protein which has two immunoglobulin (Ig) domains and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NBR8",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0009897 external side of plasma membrane;GO:0042734 presynaptic membrane;GO:0060077 inhibitory synapse",
        "go_biological_process": "GO:0099550 trans-synaptic signaling, modulating synaptic transmission;GO:0060074 synapse maturation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q96ID5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96PQ5-1",
        "uniprot_id": "IPP2L_HUMAN",
        "mass": 22863.0,
        "length": 205,
        "protein_name": "Putative protein phosphatase inhibitor 2-like protein 1",
        "gene_name": "PPP1R2P1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "PPP1R2P1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative protein phosphatase inhibitor 2-like protein 1; Protein phosphatase 1, regulatory subunit 2 pseudogene 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "10.1101/2023.09.13.557529;11696978;30379171;30620550;33981976",
        "class_list": "",
        "function": "Inhibitor of protein-phosphatase 1., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004864 protein phosphatase inhibitor activity",
        "go_cellular_component": "",
        "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0005977 glycogen metabolic process;GO:0009966 regulation of signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q96PQ5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96T52-1",
        "uniprot_id": "IMP2L_HUMAN",
        "mass": 19718.0,
        "length": 175,
        "protein_name": "Mitochondrial inner membrane protease subunit 2",
        "gene_name": "IMMP2L",
        "organism": "Human",
        "refseq_name": "mitochondrial inner membrane protease subunit 2 isoform a",
        "refseq_ac": "NP_001231535",
        "gene_names_uniprotkb": "IMMP2L",
        "gene_names_refseq": "IMMP2L-IT1; IMMP2L; IMP2-LIKE; IMP2",
        "protein_names_uniprotkb": "Mitochondrial inner membrane protease subunit 2; 3.4.21.-; IMP2-like protein",
        "protein_names_refseq": "IMP2 inner mitochondrial membrane peptidase-like; IMP2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like; mitochondrial inner membrane protease subunit 2 isoform a; mitochondrial inner membrane protease subunit 2",
        "tax_id": 9606,
        "disease": "Gilles de la Tourette syndrome (Disease Ontology:DOID:11119)",
        "pathway": " (hsa:83943)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "11237011;11254443;15814844;19058789;19240061;19401682;26992070;28228285;28834231;28904123;29242379;30379171;30410026;30524438;30833945;31154438;31844290;32157095;32350084;33849037;33936100;34171305;35251023;35580925;35776734;36241641",
        "class_list": "",
        "function": "AUTS1/AUTS5 linkage to immp2l-dock4 may be involved in autism susceptibility GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Differential DNA Methylation of the IMMP2L Gene in Families with Maternally Inherited 7q31.1 Microdeletions is Associated with Intellectual Disability and Developmental Delay., [RefSeq, PubMed]; Exonic deletions in IMMP2L in schizophrenia with enhanced glycation stress subtype. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; This gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex. Two variants that encode the same protein have been described for this gene. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q75MF1;Q75MN9;Q75MP0;Q75MS5;Q75MS8;Q96HJ2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0009003 signal peptidase activity",
        "go_cellular_component": "GO:0042720 mitochondrial inner membrane peptidase complex;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane",
        "go_biological_process": "GO:0006627 protein processing involved in protein targeting to mitochondrion;GO:0006465 signal peptide processing",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q96T52-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BXS1-1",
        "uniprot_id": "IDI2_HUMAN",
        "mass": 26753.0,
        "length": 227,
        "protein_name": "Isopentenyl-diphosphate delta-isomerase 2",
        "gene_name": "IDI2",
        "organism": "Human",
        "refseq_name": "isopentenyl-diphosphate delta-isomerase 2",
        "refseq_ac": "NP_150286",
        "gene_names_uniprotkb": "IDI2",
        "gene_names_refseq": "IDI2; IPPI2",
        "protein_names_uniprotkb": "Isopentenyl-diphosphate delta-isomerase 2; 5.3.3.2; IPP isomerase 2; IPPI2; Isopentenyl pyrophosphate isomerase 2",
        "protein_names_refseq": "IPP isomerase 2; diphosphate dimethylallyl diphosphate isomerase 2; isopentenyl pyrophosphate isomerase 2; isopentenyl-diphosphate delta-isomerase 2",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:91734);  (R-HSA-9969896)",
        "pathway_count": 2,
        "publication_count": 32,
        "publication_id_list": "10026212;10620343;10666321;10896663;11160603;1377680;14629038;14729858;14730012;14766201;16464866;16519518;16684881;17202134;18327899;18937434;20394422;20955688;21420384;25950736;31844290;33246356;33298915;34561969;39894887;5918048;7911016;7913309;8593458;8806705;9380443;9741684",
        "class_list": "",
        "function": "Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)., [UniProtKB, PubMed]; Enzyme kinetic analysis; both isozymes IDI1 and IDI2 are localized to the peroxisome by a PTS1-dependent pathway; data suggest that IDI2 is regulated independently from IDI1, by a mechanism that may involve PPARalpha, [RefSeq, PubMed]; IDI2 is expressed at high levels only in skeletal muscle, where it may be involved in the specialized production of isoprenyl diphosphates for the posttranslational modification of proteins., [RefSeq, PubMed]; The present findings suggest that IDI1 and IDI2 may be associated with the production of cholesterol metabolites in neurons, leading to alpha-synuclein aggregation during the process of Lewy body formation., [RefSeq, PubMed]; The protein encoded by this gene catalyzes the conversion of isopentenyl diphosphate to dimethylallyl diphosphate, which is a precursor for the synthesis of cholesterol and other isoprenoids. This gene, which is a product of an ancestral gene duplication event, encodes a protein that may be involved in the aggregation of alpha-synuclein in the cerebral cortex of patients with Lewy body disease. In addition, segmental copy number gains in this locus have been associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2016]., [RefSeq]; Within the 40-kb region on 10p15.3 subtelomere, which harbours two genes encoding isopentenyl diphosphate isomerase 1 (IDI1) and IDI2, there was found a segmental copy-number gain in a large proportion of sporadic amyotrophic lateral sclerosis patients., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "5.3.3.2",
        "go_molecular_function": "GO:0004452 isopentenyl-diphosphate delta-isomerase activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005829 cytosol",
        "go_biological_process": "GO:0009240 isopentenyl diphosphate biosynthetic process;GO:0050992 dimethylallyl diphosphate biosynthetic process;GO:0046490 isopentenyl diphosphate metabolic process;GO:0006695 cholesterol biosynthetic process;GO:0008299 isoprenoid biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q9BXS1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BZV3-1",
        "uniprot_id": "IMPG2_HUMAN",
        "mass": 138621.0,
        "length": 1241,
        "protein_name": "Interphotoreceptor matrix proteoglycan 2",
        "gene_name": "IMPG2",
        "organism": "Human",
        "refseq_name": "interphotoreceptor matrix proteoglycan 2 precursor",
        "refseq_ac": "NP_057331",
        "gene_names_uniprotkb": "IMPG2; IPM200",
        "gene_names_refseq": "IMPG2; IPM200; RP56; SPACRCAN; VMD5",
        "protein_names_uniprotkb": "Interphotoreceptor matrix proteoglycan 2; IPM 200; Interphotoreceptor matrix proteoglycan of 200 kDa; Sialoprotein associated with cones and rods proteoglycan; Spacrcan",
        "protein_names_refseq": "IPM 200; interphotoreceptor matrix proteoglycan 2 precursor; interphotoreceptor matrix proteoglycan IPM 200; interphotoreceptor matrix proteoglycan of 200 kDa; sialoprotein associated with cones and rods proteoglycan",
        "tax_id": 9606,
        "disease": "vitelliform macular dystrophy (Disease Ontology:DOID:0050661); retinitis pigmentosa 56 (Disease Ontology:DOID:0110371)",
        "pathway": " (hsa:50939)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "10542133;10702256;11726612;15044457;20673862;24715725;24876279;25085631;25418920;28644393;29777959;31264916;31694913;31844290;33141586;34087483;34171305;34990796;35051231;35494241;35608844;36241641;37806544",
        "class_list": "",
        "function": "Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin., [UniProtKB, PubMed]; IMPG2 mutation is associated with retinal dystrophy., [RefSeq, PubMed]; IMPG2-Related Maculopathy., [RefSeq, PubMed]; IPM 200 represents the second member of a novel family of retinal proteoglycans suspected to be involved in retinal adhesion and photoreceptor cell survival, [RefSeq, PubMed]; Identification of a Complex Allele in IMPG2 as a Cause of Adult-Onset Vitelliform Macular Dystrophy., [RefSeq, PubMed]; The protein encoded by this gene binds chondroitin sulfate and hyaluronan and is a proteoglycan. The encoded protein plays a role in the organization of the interphotoreceptor matrix and may promote the growth and maintenance of the light-sensitive photoreceptor outer segment. Defects in this gene are a cause of retinitis pigmentosa type 56 and maculopathy, IMPG2-related.[provided by RefSeq, Mar 2011]., [RefSeq]; Upon disruption of the myosin-tail homology domain, inner segment plasma membrane proteins, including syntaxin 3 (STX3), synaptosome-associated protein 25 (SNAP25), and interphotoreceptor matrix proteoglycan 2 (IMPG2), rapidly accumulated in the outer segment., [RefSeq, PubMed]; Whole exome sequencing identifies a novel splice-site mutation in IMPG2 gene causing Stargardt-like juvenile macular dystrophy in a north Indian family., [RefSeq, PubMed]",
        "predicted_glycosites": 11,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 5,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 65,
        "reported_interactions": 1,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 11,
        "binding_glycan_count": 1,
        "secondary_ac_list": "A8MWT5;Q9UKD4;Q9UKK5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008201 heparin binding;GO:0005201 extracellular matrix structural constituent;GO:0005540 hyaluronic acid binding",
        "go_cellular_component": "GO:0033165 interphotoreceptor matrix;GO:0031012 extracellular matrix;GO:0043235 receptor complex;GO:0140150 gel phase of interstitial matrix",
        "go_biological_process": "GO:0007601 visual perception",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q9BZV3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9HB29-1",
        "uniprot_id": "ILRL2_HUMAN",
        "mass": 65405.0,
        "length": 575,
        "protein_name": "Interleukin-1 receptor-like 2",
        "gene_name": "IL1RL2",
        "organism": "Human",
        "refseq_name": "interleukin-1 receptor-like 2 isoform a precursor",
        "refseq_ac": "NP_003845",
        "gene_names_uniprotkb": "IL1RL2; IL1RRP2",
        "gene_names_refseq": "IL-1Rrp2; IL-36R; IL1R-rp2; IL1RL2; IL1RRP2",
        "protein_names_uniprotkb": "Interleukin-1 receptor-like 2; 3.2.2.6; IL-1Rrp2; IL-36 receptor; IL-36R; IL1R-rp2; Interleukin-1 receptor-related protein 2",
        "protein_names_refseq": "IL-1 receptor-related protein 2; IL-36 receptor; interleukin-1 receptor-like 2 isoform a precursor; interleukin-1 receptor-related protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8808);  (R-HSA-9007892);  (R-HSA-9014826)",
        "pathway_count": 3,
        "publication_count": 24,
        "publication_id_list": "10882729;11237011;11466363;14734551;15123616;16546408;16646978;20714405;21965679;22315422;24829417;25673295;26892022;29242379;29557506;31844290;35051231;35171706;36482185;36525507;37414245;38189700;39302247;8898719",
        "class_list": "",
        "function": "Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases. Review article, [RefSeq, PubMed]; IL-1alpha and IL-1beta gene polymorphisms do not act as a strong susceptibility factor for MTLE-HS in individuals of Turkish ancestry, [RefSeq, PubMed]; In Silico and In Vitro Analysis of IL36RN Alterations Reveals Critical Residues for the Function of the Interleukin-36 Receptor Complex., [RefSeq, PubMed]; Interleukin-1 Receptor-Like 2: One Receptor, Three Agonists, and Many Implications. Review article, [RefSeq, PubMed]; Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement., [RefSeq, PubMed]; Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway., [UniProtKB, UniProtKB, PubMed]; The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/ IL-23 axis., [RefSeq, PubMed]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4FU63;Q13525;Q45H74;Q53TU8;Q587I8",
        "ec_number_list": "3.2.2.6;2.4.99.20;3.2.2.-",
        "go_molecular_function": "GO:0004908 interleukin-1 receptor activity;GO:0004909 interleukin-1, type I, activating receptor activity;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0045087 innate immune response;GO:0006968 cellular defense response",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "Q9HB29-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NPH2-1",
        "uniprot_id": "INO1_HUMAN",
        "mass": 61068.0,
        "length": 558,
        "protein_name": "Inositol-3-phosphate synthase 1",
        "gene_name": "ISYNA1",
        "organism": "Human",
        "refseq_name": "inositol-3-phosphate synthase 1 isoform 2",
        "refseq_ac": "NP_001164409",
        "gene_names_uniprotkb": "ISYNA1; INO1",
        "gene_names_refseq": "INO1; INOS; IPS 1; IPS-1; IPS; ISYNA1",
        "protein_names_uniprotkb": "Inositol-3-phosphate synthase 1; 5.5.1.4; IPS 1; MI-1-P synthase; MIP synthase; Myo-inositol 1-phosphate synthase A1; Myo-inositol 1-phosphate synthase; hINO1; hIPS",
        "protein_names_refseq": "MI-1-P synthase; MIP synthase; inositol-3-phosphate synthase 1 isoform 2; myo-inositol 1-phosphate synthase A1; testis secretory sperm-binding protein Li 200a",
        "tax_id": 9606,
        "disease": "acquired metabolic disease (Disease Ontology:DOID:0060158); azoospermia (Disease Ontology:DOID:14227)",
        "pathway": " (hsa:51477);  (R-HSA-1855183)",
        "pathway_count": 2,
        "publication_count": 53,
        "publication_id_list": "10593988;11237011;12890864;12941308;1377913;15024000;15464731;15474001;15504367;17068342;17121280;1718960;17901568;17988368;18364358;22707096;23301498;23902760;25576301;27600516;27846572;27920218;29242379;29557506;29786170;30429286;30484775;31495492;31844290;32157095;32488085;32502341;32779876;33936100;33968037;33981976;34087483;34171305;34229054;35051231;35251023;35580925;36215666;36241641;36871899;37105506;7608176;7721860;7761412;8006039;8390685;9295334;9430698",
        "class_list": "",
        "function": "Cigarette smoke induces the ROS accumulation and iNOS activation through deactivation of Nrf-2/SIRT3 axis to mediate the human bronchial epithelium ferroptosis., [RefSeq, PubMed]; Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (PubMed:15024000, PubMed:23902760). Rate-limiting enzyme in the synthesis of all inositol-containing compounds (PubMed:15024000)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; MIP synthase expressed in developing fetal liver and shows optima pH between 7.0 and 7.5., [RefSeq, PubMed]; Musashi2 promotes the progression of pancreatic cancer through a novel ISYNA1-p21/ZEB-1 pathway., [RefSeq, PubMed]; The ISYNA1 was an important regulatory factors and related networks were involved in multiple functional processes., [RefSeq, PubMed]; The myo-inositol biosynthesis rate-limiting enzyme ISYNA1 suppresses the stemness of ovarian cancer via Notch1 pathway., [RefSeq, PubMed]; This gene encodes an inositol-3-phosphate synthase enzyme. The encoded protein plays a critical role in the myo-inositol biosynthesis pathway by catalyzing the rate-limiting conversion of glucose 6-phosphate to myoinositol 1-phosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]., [RefSeq]; Upregulation occurs through the interaction of several low-affinity E2F binding motifs present in the minimal promoter., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KRT1;G5E9U0;Q6NXT5;Q7Z525;Q9BT65;Q9H2Y2;Q9NSU0;Q9NVW7",
        "ec_number_list": "5.5.1.4",
        "go_molecular_function": "GO:0004512 inositol-3-phosphate synthase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006021 inositol biosynthetic process;GO:0008654 phospholipid biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "Q9NPH2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NRR6-1",
        "uniprot_id": "INP5E_HUMAN",
        "mass": 70205.0,
        "length": 644,
        "protein_name": "Phosphatidylinositol polyphosphate 5-phosphatase type IV",
        "gene_name": "INPP5E",
        "organism": "Human",
        "refseq_name": "phosphatidylinositol polyphosphate 5-phosphatase type IV isoform 2",
        "refseq_ac": "NP_001305431",
        "gene_names_uniprotkb": "INPP5E",
        "gene_names_refseq": "CORS1; CPD4; INPP5E; JBTS1; MORMS; PPI5PIV; pharbin",
        "protein_names_uniprotkb": "Phosphatidylinositol polyphosphate 5-phosphatase type IV; 3.1.3.36; 3.1.3.86; 72 kDa inositol polyphosphate 5-phosphatase; Inositol polyphosphate-5-phosphatase E; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase",
        "protein_names_refseq": "72 kDa inositol polyphosphate 5-phosphatase; phosphatidylinositol polyphosphate 5-phosphatase type IV isoform 2; phosphatidylinositol polyphosphate 5-phosphatase type IV; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; phosphatidylinositol-4,5-bisphosphate 5-phosphatase",
        "tax_id": 9606,
        "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); Joubert syndrome 1 (Disease Ontology:DOID:0110980); obesity (Disease Ontology:DOID:9970); MORM syndrome (MONDO:MONDO:0012423)",
        "pathway": " (hsa:56623);  (R-HSA-1660514);  (R-HSA-5624958)",
        "pathway_count": 3,
        "publication_count": 59,
        "publication_id_list": "10101268;10419465;10559940;10567352;10764818;10766823;10805725;10806194;11237011;11279162;11706043;11716755;11923287;12324459;14527956;14659893;17287340;17525332;17555535;17556371;18950639;19211563;19668215;19668216;23034536;23150559;23186163;23386033;24166846;25576301;26992070;28228285;28904123;29052317;29242379;29557506;30796923;31844290;32157095;32357974;32387766;32938616;33298915;33968037;34171305;34509645;35051231;35584663;36334440;38514901;40969890;7628435;7761412;8634694;8999962;9148941;9405935;9516481;9878262",
        "class_list": "",
        "function": "Functional analysis of the mouse counterpart., [RefSeq, PubMed]; INPP5E Regulates the Distribution of Phospholipids on Cilia in RPE1 Cells., [RefSeq, PubMed]; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity) (PubMed:10764818). Specific for lipid substrates, inactive towards water soluble inositol phosphates (PubMed:10764818). Can also remove the 5-phosphate from 1D-myo-inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) (PubMed:40969890). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; TMEM67 is required for the gating function of the transition zone that controls entry of membrane-associated proteins ARL13B and INPP5E into primary cilia., [RefSeq, PubMed]; The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling., [RefSeq, PubMed]; The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q15734;Q6PIV5",
        "ec_number_list": "3.1.3.-;3.1.3.95;3.1.3.36;3.1.3.64;3.1.3.86;3.1.3.56;3.1.3.16;3.1.3.67",
        "go_molecular_function": "GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity;GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004445 inositol-polyphosphate 5-phosphatase activity;GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0017148 negative regulation of translation;GO:0006661 phosphatidylinositol biosynthetic process;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0046856 phosphatidylinositol dephosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "Q9NRR6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NSI5-1",
        "uniprot_id": "IGSF5_HUMAN",
        "mass": 44593.0,
        "length": 407,
        "protein_name": "Immunoglobulin superfamily member 5",
        "gene_name": "IGSF5",
        "organism": "Human",
        "refseq_name": "immunoglobulin superfamily member 5",
        "refseq_ac": "NP_001073913",
        "gene_names_uniprotkb": "IGSF5; JAM4",
        "gene_names_refseq": "GSF5; IGSF5; JAM4",
        "protein_names_uniprotkb": "Immunoglobulin superfamily member 5; IgSF5; JAM-4; Junctional adhesion molecule 4",
        "protein_names_refseq": "immunoglobulin superfamily 5 like; immunoglobulin superfamily member 5; junctional adhesion molecule 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:150084)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "22042635;27869121;29741879;31844290;32157095;33592498;35494241;39302247",
        "class_list": "",
        "function": "Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells (By similarity)., [UniProtKB]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005923 bicellular tight junction;GO:0009986 cell surface;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0098609 cell-cell adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q9NSI5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q16566-1",
        "uniprot_id": "KCC4_HUMAN",
        "mass": 51926.0,
        "length": 473,
        "protein_name": "Calcium/calmodulin-dependent protein kinase type IV",
        "gene_name": "CAMK4",
        "organism": "Human",
        "refseq_name": "calcium/calmodulin-dependent protein kinase type IV isoform 1",
        "refseq_ac": "NP_001310303",
        "gene_names_uniprotkb": "CAMK4; CAMK-GR; CAMKIV; CAMK",
        "gene_names_refseq": "CAMK4; CaMK IV; CaMK-GR; CaMKIV; caMK",
        "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type IV; 2.7.11.17; CaM kinase-GR; CaMK IV",
        "protein_names_refseq": "CAM kinase IV; CAM kinase- GR; brain Ca(2+)-calmodulin-dependent protein kinase type IV; brain Ca++-calmodulin-dependent protein kinase type IV; calcium/calmodulin-dependent protein kinase type IV catalytic chain; calcium/calmodulin-dependent protein kinase type IV isoform 1",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); alcohol use disorder (Disease Ontology:DOID:1574); cocaine dependence (Disease Ontology:DOID:9975)",
        "pathway": " (hsa:814);  (R-HSA-111932);  (R-HSA-2151201);  (R-HSA-442729);  (R-HSA-9022535);  (R-HSA-9022692);  (R-HSA-9617324)",
        "pathway_count": 7,
        "publication_count": 120,
        "publication_id_list": "10412986;10617605;10643692;10713165;10833263;11237011;11340167;11809803;12065094;12374852;12563009;12745923;12807427;15143065;15322089;15591024;15684387;15769749;16079181;16079853;16788062;16890199;16908542;16911507;17031457;17046689;17192257;17344846;17437997;17715127;17909078;17923681;17994015;18215119;18343819;18680753;18817731;18829949;18930438;19001277;19225110;19331822;19356719;19413330;19417006;19506079;19538941;19690332;19820693;19951946;21957496;22311971;22564745;23481700;23770565;23770587;24714562;24715725;26154972;26239616;26853435;26992070;27600516;27893789;27935279;28228285;28649982;28832583;28904123;29242379;29393594;29493099;29508533;29557506;30192525;30296064;30315122;31217245;31530632;31844290;31937595;32157095;32350084;32357974;32502341;32738170;32983136;33141586;33298915;33709700;33784256;33912179;34725712;35051231;35154160;36002021;38287012;38665916;7615569;7629110;7799916;7961813;8065343;8089075;8107230;8108407;8194751;8333869;8397199;8621423;8702940;8855261;8980227;9154845;9163534;9178750;9286700;9620804;9822657;9920409",
        "class_list": "",
        "function": "Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis. Publication Status: Online-Only, [RefSeq, PubMed]; CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses. Publication Status: Online-Only, [RefSeq, PubMed]; CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation., [RefSeq, PubMed]; CaMK4 promotes abortion-related Th17 cell imbalance by activating AKT/mTOR signaling pathway., [RefSeq, PubMed]; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 7,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DSZ7",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;3.5.1.-;3.5.1.98;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.1.3.16;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0009931 calcium-dependent protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0070062 extracellular exosome;GO:0001650 fibrillar center",
        "go_biological_process": "GO:0033081 regulation of T cell differentiation in thymus;GO:0006468 protein phosphorylation;GO:0006954 inflammatory response;GO:0007165 signal transduction;GO:0035556 intracellular signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 12.9,
        "record_id": "Q16566-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z794-1",
        "uniprot_id": "K2C1B_HUMAN",
        "mass": 61901.0,
        "length": 578,
        "protein_name": "Keratin, type II cytoskeletal 1b",
        "gene_name": "KRT77",
        "organism": "Human",
        "refseq_name": "keratin, type II cytoskeletal 1b",
        "refseq_ac": "NP_778253",
        "gene_names_uniprotkb": "KRT77; KRT1B",
        "gene_names_refseq": "K1B; KRT1B; KRT77",
        "protein_names_uniprotkb": "Keratin, type II cytoskeletal 1b; CK-1B; Cytokeratin-1B; K77; Keratin-77; Type-II keratin Kb39",
        "protein_names_refseq": "CK-1B; K77; cytokeratin-1B; keratin 1B; keratin 77, type II; keratin, type II cytoskeletal 1b; type-II keratin Kb39",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:374454);  (R-HSA-6805567);  (R-HSA-6809371)",
        "pathway_count": 3,
        "publication_count": 64,
        "publication_id_list": "10066784;10196183;10231017;10411887;10588656;10771479;11237011;11350120;11380615;11590230;11683385;12902340;15033990;15337775;15373777;15737194;15797384;15803139;16061697;16117782;16382671;16639001;1691188;1694855;1714783;17515931;17521629;17562024;17596512;18843291;19190773;19194479;20179351;20657595;20667819;20940292;21439340;21654840;21997417;23481192;23629652;2414304;25208914;25645385;25926655;26375851;26390218;29557506;31717259;32387766;32927888;34087483;34171305;35051231;36010968;37217939;38665916;41018975;7543090;8824274;8999895;9395522;9468612;9565599",
        "class_list": "",
        "function": "Epithelial keratin, K1b, is exclusively expressed in luminal duct cells of eccrine sweat glands., [RefSeq, PubMed]; Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]., [RefSeq]; Molecular Modeling of Pathogenic Mutations in the Keratin 1B Domain. Publication Status: Online-Only, [RefSeq, PubMed]; Structural component of intermediate filaments in epithelial cells of stratified epithelia. Assembles into heteropolymers with a type I keratin, forming keratin intermediate filament networks contributing to epithelial integrity., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7RTS8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030280 structural constituent of skin epidermis",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0070062 extracellular exosome;GO:0001533 cornified envelope;GO:0045095 keratin filament",
        "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization",
        "synthesized_glycan_count": 0,
        "hit_score": 6.7,
        "record_id": "Q7Z794-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P23276-1",
        "uniprot_id": "KELL_HUMAN",
        "mass": 82824.0,
        "length": 732,
        "protein_name": "Kell blood group glycoprotein",
        "gene_name": "KEL",
        "organism": "Human",
        "refseq_name": "kell blood group glycoprotein",
        "refseq_ac": "NP_000411",
        "gene_names_uniprotkb": "KEL",
        "gene_names_refseq": "CD238; ECE3; KEL; Kell",
        "protein_names_uniprotkb": "Kell blood group glycoprotein; 3.4.24.-",
        "protein_names_refseq": "Kell blood group antigen; Kell blood group protein; Kell blood group, metallo-endopeptidase; Kell glycoprotein; bloodgroup KEL protein; kell blood group glycoprotein",
        "tax_id": 9606,
        "disease": "obsolete blood group--kell system (MONDO:MONDO:0020611)",
        "pathway": " (hsa:3792);  (R-HSA-375276)",
        "pathway_count": 2,
        "publication_count": 112,
        "publication_id_list": "10079109;10100623;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10604470;10854085;10891471;10899166;11237011;11322507;11336649;11385580;11457843;11562423;11683476;11773063;12427552;12540846;12719537;1280419;12842980;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;15139756;15539556;1567413;15947423;1655761;1710450;1710578;1712490;1719979;1722333;18127230;1847994;23186163;23446738;23690594;24906252;2649896;27496565;29557506;3202875;32350084;3366244;34137046;35140839;35251023;3525564;35852066;37074911;3856870;38644556;6274691;6281660;6373251;6589611;7057924;7524088;7570911;7590751;7592910;7592911;7624359;7797512;7849312;7858266;7905839;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8373420;8381365;8383682;8395824;8440682;8463333;8503909;8615752;8652402;8666380;8669078;8702752;873923;8823230;9171878;9354821;9521323;9530155;9593744;9607765;9685625;9722565;9792798;9832121;9851594",
        "class_list": "",
        "function": "Epigenetic dissection of human blood group genes reveals regulatory elements and detailed characteristics of KEL and four other loci., [RefSeq, PubMed]; Functional Evaluation of KEL as an Oncogenic Gene in the Progression of Acute Erythroleukemia. Publication Status: Online-Only, [RefSeq, PubMed]; Novel KEL allele associated with loss of Kp(b) identified in a white blood donor. Publication Status: Online-Only, [RefSeq, PubMed]; Novel KEL*02N allele in Saudi Arabia encoding a Kell null (K0 ) phenotype., [RefSeq, PubMed]; This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. [provided by RefSeq, Jul 2008]., [RefSeq]; X-ray analysis of Kell blood group protein, [RefSeq, PubMed]; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3., [UniProtKB, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 46,
        "reported_interactions": 0,
        "missing_score": 9671,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RBV4;Q96RS8;Q99885",
        "ec_number_list": "3.4.24.-",
        "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0016485 protein processing;GO:0042310 vasoconstriction;GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 11.7,
        "record_id": "P23276-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14498-1",
        "uniprot_id": "ISLR_HUMAN",
        "mass": 45997.0,
        "length": 428,
        "protein_name": "Immunoglobulin superfamily containing leucine-rich repeat protein",
        "gene_name": "ISLR",
        "organism": "Human",
        "refseq_name": "immunoglobulin superfamily containing leucine-rich repeat protein precursor",
        "refseq_ac": "NP_005536",
        "gene_names_uniprotkb": "ISLR; PRO215",
        "gene_names_refseq": "HsT17563; ISLR; Meflin",
        "protein_names_uniprotkb": "Immunoglobulin superfamily containing leucine-rich repeat protein",
        "protein_names_refseq": "immunoglobulin superfamily containing leucine-rich repeat protein precursor; immunoglobulin superfamily containing leucine-rich repeat protein; mesenchymal stromal cell- and fibroblast-expressing Linx paralogue",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3671);  (R-HSA-114608)",
        "pathway_count": 2,
        "publication_count": 26,
        "publication_id_list": "10512678;11237011;12975309;1435334;14630798;15297306;16959974;23640497;25418920;29557506;29741879;30459171;31844290;32128839;33197448;33633747;34087483;34171305;34713300;35051231;37074911;37796386;38786060;6457647;8467233;9325048",
        "class_list": "",
        "function": "Immunoglobulin Superfamily Containing Leucine-Rich Repeat (ISLR) Serves as a Redox Sensor That Modulates Antioxidant Capacity by Suppressing Pyruvate Kinase Isozyme M2 Activity. Publication Status: Online-Only, [RefSeq, PubMed]; Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas., [RefSeq, PubMed]; Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling., [RefSeq, PubMed]; Silencing of ISLR inhibits tumour progression and glycolysis by inactivating the IL6/JAK/STAT3 pathway in nonsmall cell lung cancer., [RefSeq, PubMed]; The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis. Erratum:[Gastroenterology. 2021 Nov;161(5):1728. doi: 10.1053/j.gastro.2021.09.038. PMID: 34562358], [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 8593,
        "biomarker_type": "",
        "glycan_count": 23,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0031093 platelet alpha granule lumen;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0007155 cell adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "O14498-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43448-1",
        "uniprot_id": "KCAB3_HUMAN",
        "mass": 43670.0,
        "length": 404,
        "protein_name": "Voltage-gated potassium channel subunit beta-3",
        "gene_name": "KCNAB3",
        "organism": "Human",
        "refseq_name": "voltage-gated potassium channel subunit beta-3",
        "refseq_ac": "NP_004723",
        "gene_names_uniprotkb": "KCNAB3; KCNA3B",
        "gene_names_refseq": "AKR6A9; KCNA3.1B; KCNA3B; KCNAB3; KV-BETA-3",
        "protein_names_uniprotkb": "Voltage-gated potassium channel subunit beta-3; 1.1.1.-; K(+) channel subunit beta-3; Kv-beta-3",
        "protein_names_refseq": "K(+) channel subunit beta-3; potassium channel, voltage gated subfamily A regulatory beta subunit 3; potassium channel, voltage-dependent, beta-3 subunit; potassium voltage-gated channel, shaker-related subfamily, beta member 3; voltage-gated potassium channel subunit beta-3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9196);  (R-HSA-1296072)",
        "pathway_count": 2,
        "publication_count": 14,
        "publication_id_list": "11237011;17081983;20393197;21231794;25802875;28411811;30379171;31844290;32387766;32990398;33592498;35051231;36215666;9857044",
        "class_list": "",
        "function": "H258R mutation in KCNAB3 gene in a family with genetic epilepsy and febrile seizures plus., [RefSeq, PubMed]; Regulatory subunit of the voltage-gated potassium (Kv) channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunit (PubMed:9857044). The beta-3/KCNAB3 subunit may mediate closure of potassium channels (By similarity). Increases inactivation of Kv1.5/KCNA5 alpha subunit-containing channels (PubMed:9857044). May display nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity (By similarity). The binding of oxidized and reduced NADP(H) cofactors may be required for the regulation of potassium channel activity (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. The encoded protein is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. The encoded protein forms a heterodimer with the potassium voltage-gated channel, shaker-related subfamily, member 5 gene product and regulates the activity of the alpha subunit. [provided by RefSeq, May 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4VAW0",
        "ec_number_list": "1.1.1.-",
        "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0005249 voltage-gated potassium channel activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0008076 voltage-gated potassium channel complex",
        "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0006813 potassium ion transport",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "O43448-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q17RG1-1",
        "uniprot_id": "KCD19_HUMAN",
        "mass": 104938.0,
        "length": 926,
        "protein_name": "BTB/POZ domain-containing protein KCTD19",
        "gene_name": "KCTD19",
        "organism": "Human",
        "refseq_name": "BTB/POZ domain-containing protein KCTD19",
        "refseq_ac": "NP_001094385",
        "gene_names_uniprotkb": "KCTD19",
        "gene_names_refseq": "KCTD19",
        "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD19; Potassium channel tetramerization domain-containing protein 19",
        "protein_names_refseq": "BTB/POZ domain-containing protein KCTD19; potassium channel tetramerisation domain containing 19; potassium channel tetramerization domain-containing protein 19; testicular tissue protein Li 101",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:146212)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;28904123;32157095;33392160;33912179;34171305;34561969;34932366;35051231;37192818;37257643",
        "class_list": "",
        "function": "Biallelic variants in KCTD19 associated with male factor infertility and oligoasthenoteratozoospermia., [RefSeq, PubMed]; Homozygous nonsense variants of KCTD19 cause male infertility in humans and mice., [RefSeq, PubMed]; Transcription regulator which is essential for male fertility and for the completion of meiotic prophase in spermatocytes. Regulates progression of the pachytene stage of meiotic prophase and promotes the transcriptional activation activity ZNF541. Required for the organization of chromosomes during metaphase I., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DZ49;Q8N804",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0051260 protein homooligomerization;GO:0007140 male meiotic nuclear division",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q17RG1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P35527-1",
        "uniprot_id": "K1C9_HUMAN",
        "mass": 62064.0,
        "length": 623,
        "protein_name": "Keratin, type I cytoskeletal 9",
        "gene_name": "KRT9",
        "organism": "Human",
        "refseq_name": "keratin, type I cytoskeletal 9",
        "refseq_ac": "NP_000217",
        "gene_names_uniprotkb": "KRT9",
        "gene_names_refseq": "CK-9; EPPK; K9; KRT9",
        "protein_names_uniprotkb": "Keratin, type I cytoskeletal 9; CK-9; Cytokeratin-9; K9; Keratin-9",
        "protein_names_refseq": "cytokeratin 9; keratin 9, type I; keratin, type I cytoskeletal 9; type I cytoskeletal 9",
        "tax_id": 9606,
        "disease": "epidermolytic palmoplantar keratoderma 1 (Disease Ontology:DOID:0070552); epidermolytic palmoplantar keratoderma (Disease Ontology:DOID:0080223); knuckle pads (MONDO:MONDO:0007865)",
        "pathway": " (hsa:3857);  (R-HSA-6805567);  (R-HSA-6809371)",
        "pathway_count": 3,
        "publication_count": 153,
        "publication_id_list": "10066784;10196183;10201533;10218578;10231017;10411887;10588656;10632938;10771479;10844507;11237011;11350120;11380615;11590230;12072061;12192490;12838553;12902340;12926810;14654843;14675368;15033990;15099359;15115518;15337775;15373777;15605275;15797384;15803139;16061697;16382671;16639001;16911293;1691188;1694855;16961539;1714783;17515931;17521629;17562024;17596512;18160138;18669648;18843291;19190773;19194479;19874353;20179351;20657595;20667819;20940292;20964665;2140676;21439340;21654840;21715251;21997417;22967762;23481192;23629652;2414304;24397554;25208914;25418920;25505266;25645385;25810538;25926655;26154972;26375851;26390218;26853435;26992070;27452731;27543614;27600516;27862975;27920218;28228285;28514659;28649982;28855257;28935714;29314611;29317506;29391424;29393594;29508533;29557506;29719290;29786170;29802537;30120933;30315122;30429286;30524438;30626607;30779550;31061102;31217245;31525823;31611695;31844290;31937595;32157095;32161166;32162841;32350084;32357974;32373127;32387766;32488085;32938616;33043033;33214551;33912179;33968037;33981976;34019948;34046748;34078123;34087483;34171305;34211107;34357683;34509645;35051231;35154160;35561310;35580925;36010968;36241641;37217939;37938771;38665916;39534244;39990658;41018975;7507869;7511021;7512862;7516304;7523529;7532199;7543090;8647270;8824274;8999895;9204965;9395522;9468612;9565599;9856842",
        "class_list": "",
        "function": "A novel heterozygous c.1369C>T transition (p.Leu457Phe) in exon 6 of the KRT9 gene was identified in four patients in a Chinese Family with Epidermolytic Palmoplantar Keratoderma., [RefSeq, PubMed]; Cytokeratin 7 and 19 expression in oropharyngeal and oral squamous cell carcinoma., [RefSeq, PubMed]; Exogenous dsRNA inhibits KRT9 expression in early passage volar keratinocytes or in vivo footpads of wild-type mice. Loss of DDX58 in passaged volar keratinocytes rescues KRT9 and inhibits KRT7 expression., [RefSeq, PubMed]; KRT9 L164P mutation is associated with epidermolytic palmoplantar keratoderma. Review article, [RefSeq, PubMed]; Keratin 9 is an Hsp70 client protein and is expressed in human bladder cancer cells., [RefSeq, PubMed]; Structural component of intermediate filaments in suprabasal keratinocytes of palmoplantar epidermis. Forms heteropolymers with a type II keratin, assembling into keratin intermediate filament networks that maintain the mechanical integrity of the palmoplantar epidermis., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes the type I keratin 9, an intermediate filament chain expressed only in the terminally differentiated epidermis of palms and soles. Mutations in this gene cause epidermolytic palmoplantar keratoderma. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 32,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 13,
        "disease_count": 3,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O00109;Q0IJ47;Q14665",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0030280 structural constituent of skin epidermis;GO:0005198 structural molecule activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0016020 membrane",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030855 epithelial cell differentiation;GO:0008544 epidermis development;GO:0043588 skin development;GO:0045109 intermediate filament organization",
        "synthesized_glycan_count": 0,
        "hit_score": 17.4,
        "record_id": "P35527-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43526-1",
        "uniprot_id": "KCNQ2_HUMAN",
        "mass": 95848.0,
        "length": 872,
        "protein_name": "Potassium voltage-gated channel subfamily KQT member 2",
        "gene_name": "KCNQ2",
        "organism": "Human",
        "refseq_name": "potassium voltage-gated channel subfamily KQT member 2 isoform c",
        "refseq_ac": "NP_004509",
        "gene_names_uniprotkb": "KCNQ2",
        "gene_names_refseq": "BFNC; DEE7; EBN1; EBN; ENB1; HNSPC; KCNA11; KCNQ2; KV7.2",
        "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily KQT member 2; KQT-like 2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; Voltage-gated potassium channel subunit Kv7.2",
        "protein_names_refseq": "neuroblastoma-specific potassium channel subunit alpha KvLQT2; potassium channel, voltage gated KQT-like subfamily Q, member 2; potassium voltage-gated channel subfamily KQT member 2 isoform c; potassium voltage-gated channel subfamily KQT member 2; voltage-gated potassium channel subunit Kv7.2",
        "tax_id": 9606,
        "disease": "developmental and epileptic encephalopathy 7 (Disease Ontology:DOID:0080462); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); heart conduction disease (Disease Ontology:DOID:10273); benign neonatal seizures (Disease Ontology:DOID:14264); long QT syndrome (Disease Ontology:DOID:2843)",
        "pathway": " (hsa:3785);  (R-HSA-1296072);  (R-HSA-445095)",
        "pathway_count": 3,
        "publication_count": 70,
        "publication_id_list": "10323247;10479678;10684873;10713399;10713961;10781098;10788442;10908292;10953053;11034315;11160379;11175290;11222639;11237011;11572947;12742592;12754513;14534157;14759258;15249611;16319223;16597699;16904324;17223356;17872363;20393197;21231794;23360469;24277843;24463883;25576301;25740509;25818041;25880248;25982755;26138355;26993267;27445338;27564677;27846572;27864847;28218747;28793216;28832583;29437277;30315122;30410026;31844290;32350084;32387766;32884139;33298915;33981976;35051231;35494241;36241641;37857637;38108335;38142737;38236165;38253038;38788659;38814296;9039501;9425895;9430594;9677360;9827540;9836639;9872318",
        "class_list": "",
        "function": "Clinical and genetic analysis of 18 patients with KCNQ2 mutations from South China. Publication Status: Online-Only, [RefSeq, PubMed]; Effect of a sensing charge mutation on the deactivation of KV7.2 channels., [RefSeq, PubMed]; Familial KCNQ2 mutation: a psychiatric perspective., [RefSeq, PubMed]; Improved classification and pathogenicity assessment by comprehensive functional studies in a large data set of KCNQ2 variants., [RefSeq, PubMed]; KCNQ2 mutations cause unique neonatal behavior arrests without motor seizures: Functional characterization., [RefSeq, PubMed]; Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:24277843, PubMed:28793216, PubMed:9836639). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (PubMed:10781098, PubMed:14534157, PubMed:32884139, PubMed:37857637, PubMed:9836639). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed:14534157, PubMed:28793216, PubMed:9836639). KCNQ2-KCNQ3 M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (PubMed:28793216). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed:28793216). Suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873, PubMed:10713961)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability.  The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43796;O75580;O95845;Q4VXP4;Q4VXR6;Q5VYT8;Q96J59;Q99454",
        "ec_number_list": "1.8.-.-",
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0030506 ankyrin binding;GO:0005249 voltage-gated potassium channel activity;GO:0022843 voltage-gated monoatomic cation channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse;GO:0008076 voltage-gated potassium channel complex;GO:0033268 node of Ranvier",
        "go_biological_process": "GO:0007399 nervous system development;GO:0001508 action potential;GO:0007268 chemical synaptic transmission;GO:0071805 potassium ion transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 7.3,
        "record_id": "O43526-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P14616-1",
        "uniprot_id": "INSRR_HUMAN",
        "mass": 143720.0,
        "length": 1297,
        "protein_name": "Insulin receptor-related protein",
        "gene_name": "INSRR",
        "organism": "Human",
        "refseq_name": "insulin receptor-related protein precursor",
        "refseq_ac": "NP_055030",
        "gene_names_uniprotkb": "INSRR; IRR",
        "gene_names_refseq": "INSRR; IRR",
        "protein_names_uniprotkb": "Insulin receptor-related protein; 2.7.10.1; IR-related receptor; IRR",
        "protein_names_refseq": "IR-related receptor; insulin receptor-related protein precursor; insulin receptor-related protein",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162); high grade glioma (Disease Ontology:DOID:3070); glucose metabolism disease (Disease Ontology:DOID:4194); sleep disorder (Disease Ontology:DOID:535); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743)",
        "pathway": " (hsa:3645)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "10226785;17344846;18767875;21641549;2768234;31848261;32157095;32502341;32708676;33912179;35051231;36010968;37099121",
        "class_list": "",
        "function": "Identification of INSRR as an immune-related gene in the tumor microenvironment of glioblastoma by integrated bioinformatics analysis. Publication Status: Online-Only, [RefSeq, PubMed]; Probing Structure and Function of Alkali Sensor IRR with Monoclonal Antibodies. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB., [UniProtKB, PubMed]",
        "predicted_glycosites": 10,
        "predicted_n_glycosites": 10,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 9,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 54,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 9,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60724;Q5VZS3",
        "ec_number_list": "2.7.12.2;2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.1.40;2.7.1.32;2.7.1.82;2.7.10.4;2.7.11.13;2.7.11.23",
        "go_molecular_function": "GO:0005009 insulin receptor activity;GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0043560 insulin receptor substrate binding;GO:0043548 phosphatidylinositol 3-kinase binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043235 receptor complex;GO:0005899 insulin receptor complex",
        "go_biological_process": "GO:0071469 cellular response to alkaline pH;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030036 actin cytoskeleton organization;GO:0008286 insulin receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "P14616-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P15382-1",
        "uniprot_id": "KCNE1_HUMAN",
        "mass": 14675.0,
        "length": 129,
        "protein_name": "Potassium voltage-gated channel subfamily E member 1",
        "gene_name": "KCNE1",
        "organism": "Human",
        "refseq_name": "potassium voltage-gated channel subfamily E member 1",
        "refseq_ac": "NP_000210",
        "gene_names_uniprotkb": "KCNE1",
        "gene_names_refseq": "ISK; JLNS2; JLNS; KCNE1; LQT2/5; LQT5; MinK",
        "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily E member 1; Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; MinK; Minimal potassium channel",
        "protein_names_refseq": "IKs producing slow voltage-gated potassium channel subunit beta Mink; Long QT syndrome 5; cardiac delayed rectifier potassium channel protein; delayed rectifier potassium channel subunit IsK; minimal potassium channel; potassium channel, voltage gated subfamily E regulatory beta subunit 1; potassium voltage-gated channel subfamily E member 1; potassium voltage-gated channel, Isk-related family, member 1; potassium voltage-gated channel, Isk-related subfamily, member 1; voltage gated potassiun channel accessory subunit",
        "tax_id": 9606,
        "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); long QT syndrome 5 (Disease Ontology:DOID:0110647); Jervell-Lange Nielsen syndrome (Disease Ontology:DOID:2842); long QT syndrome (Disease Ontology:DOID:2843); seminoma (Disease Ontology:DOID:4440); congestive heart failure (Disease Ontology:DOID:6000)",
        "pathway": " (hsa:3753);  (R-HSA-5576890);  (R-HSA-5576893)",
        "pathway_count": 3,
        "publication_count": 40,
        "publication_id_list": "10219239;10400998;10646604;10973849;11692163;11874988;15051636;15266014;1553557;16414944;16823764;16939434;16949586;18093912;18611041;19219384;19716085;20533308;21669976;21676880;24591645;25037568;25966690;26307551;27147833;2730656;32833978;34282101;34285340;34958868;38816749;7586312;7828904;8899564;9230439;9312006;9328483;9354783;9354802;9445165",
        "class_list": "",
        "function": "A general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling. Publication Status: Online-Only, [RefSeq, PubMed]; Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE1 beta subunit modulates the gating kinetics and enhances stability of the channel complex (PubMed:19219384, PubMed:20533308, PubMed:9230439). Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit (PubMed:19219384). Associates with KCNQ1/KVLQT1 alpha subunit to form the slowly activating delayed rectifier cardiac potassium (IKs) channel responsible for ventricular muscle action potential repolarization (PubMed:20533308). The outward current reaches its steady state only after 50 seconds (Probable). Assembly with KCNH2/HERG alpha subunit Kv channel may regulate the rapidly activating component of the delayed rectifying potassium current (IKr) in heart (PubMed:9230439)., [UniProtKB, PubMed, PubMed, PubMed]; Association Analysis of Candidate Gene Polymorphisms and Tinnitus in Young Musicians., [RefSeq, PubMed]; High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology. Publication Status: Online-Only, [RefSeq, PubMed]; PKC-isoform specific regulation of receptor desensitization and KCNQ1/KCNE1 K(+) channel activity by mutant alpha1B-adrenergic receptors., [RefSeq, PubMed]; The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 2,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 6,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5H1P2;Q8N709;Q91Z94",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0031433 telethonin binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0005764 lysosome;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0086011 membrane repolarization during action potential;GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:0086003 cardiac muscle cell contraction;GO:0042391 regulation of membrane potential",
        "synthesized_glycan_count": 0,
        "hit_score": 4.4,
        "record_id": "P15382-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P55073-1",
        "uniprot_id": "IOD3_HUMAN",
        "mass": 33947.0,
        "length": 304,
        "protein_name": "Thyroxine 5-deiodinase",
        "gene_name": "DIO3",
        "organism": "Human",
        "refseq_name": "thyroxine 5-deiodinase",
        "refseq_ac": "NP_001353",
        "gene_names_uniprotkb": "DIO3; ITDI3; TXDI3",
        "gene_names_refseq": "5DIII; D3; DIO3; DIOIII; TXDI3",
        "protein_names_uniprotkb": "Thyroxine 5-deiodinase; 1.21.99.3; 5DIII; DIOIII; Type 3 DI; Type III iodothyronine deiodinase",
        "protein_names_refseq": "deiodinase, iodothyronine type III; iodothyronine deiodinase, placental type; selenoprotein DIO3; thyroxine 5-deiodinase; thyroxine deiodinase type III (selenoprotein); type 3 DI; type 3 iodothyronine selenodeiodinase; type-III 5' deiodinase",
        "tax_id": 9606,
        "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); congestive heart failure (Disease Ontology:DOID:6000)",
        "pathway": " (hsa:1735);  (R-HSA-350864)",
        "pathway_count": 2,
        "publication_count": 19,
        "publication_id_list": "11237011;12419801;12586771;12746313;1400883;16131329;18339710;18356288;18821722;23235188;31844290;34211107;35051231;36241641;37116683;38311851;38609422;38659084;7593630",
        "class_list": "",
        "function": "D3 expression is re-activated in various types of human cancers. It may play a role in carcinogenesis and neoplastic cell proliferation. Review. Review article, [RefSeq, PubMed]; DLK1/DIO3 locus upregulation by a beta-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis., [RefSeq, PubMed]; Evaluating the link between DIO3-FA27 promoter methylation, biochemical indices, and heart failure progression. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-24-3p/Dio3 axis is essential for BDE47 to induce local thyroid hormone disorder and neurotoxicity., [RefSeq, PubMed]; MiRNAs from the Dlk1-Dio3 locus and miR-224/452 cluster contribute to glioblastoma tumor heterogeneity. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:7593630, PubMed:12586771, PubMed:12746313, PubMed:18821722). Catalyzes the deiodination of L-thyroxine (T4) to 3,3',5'-triiodothyronine (rT3), 3,5,3'-triiodothyronine (T3) to 3,3'-diiodothyronine (3,3'-T2), 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine (3-T1), rT3 to 3',5'-diiodothyronine (3',5'-T2) and 3,3'-T2 to 3'-monoiodothyronine (3'-T1) via inner-ring deiodination (IRD) (PubMed:7593630, PubMed:12586771, PubMed:12746313, PubMed:18821722, PubMed:18339710). Catalyzes the deiodination of 3-T1 to L-thyronine (T0) via outer-ring deiodination (ORD) (PubMed:18821722). Catalyzes the tyrosyl ring deiodinations of 3,3',5,5'-tetraiodothyronamine, 3,3',5'-triiodothyronamine, 3,5,3'-triiodothyronamine, 3,5-diiodothyronamine, 3,3'-diiodothyronamine and 3-iodothyronamine (PubMed:18339710)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine)., [UniProtKB, UniProtKB]; Structure and function of the type 3 deiodinase gene [review] Review article, [RefSeq, PubMed]; Study demonstrates that D3 is located in the plasma membrane with most of its molecule in the extracellular space, allowing access to inactivate both the hormone T3 and prohormone T4, [RefSeq, PubMed]; The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in pregnant uterus, placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It regulates circulating fetal thyroid hormone concentrations, and thus plays a critical role in mammalian development. Knockout mice lacking this gene exhibit abnormalities related to development and reproduction, and increased activity of this enzyme in infants with hemangiomas causes severe hypothyroidism. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, May 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "G3XAM0;Q8WVN5",
        "ec_number_list": "1.21.99.3;1.21.99.4",
        "go_molecular_function": "GO:0033798 thyroxine 5-deiodinase activity;GO:0004800 thyroxine 5'-deiodinase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0010008 endosome membrane",
        "go_biological_process": "GO:0042404 thyroid hormone catabolic process;GO:0001666 response to hypoxia;GO:0042446 hormone biosynthetic process;GO:0042403 thyroid hormone metabolic process;GO:0070342 brown fat cell proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "P55073-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P57789-1",
        "uniprot_id": "KCNKA_HUMAN",
        "mass": 59765.0,
        "length": 538,
        "protein_name": "Potassium channel subfamily K member 10",
        "gene_name": "KCNK10",
        "organism": "Human",
        "refseq_name": "potassium channel subfamily K member 10 isoform 1 precursor",
        "refseq_ac": "NP_066984",
        "gene_names_uniprotkb": "KCNK10; TREK2",
        "gene_names_refseq": "K2p10.1; KCNK10; PPP1R97; TREK-2; TREK2",
        "protein_names_uniprotkb": "Potassium channel subfamily K member 10; Outward rectifying potassium channel protein TREK-2; TREK-2 K(+) channel subunit",
        "protein_names_refseq": "2P domain potassium channel TREK2; TREK-2 K(+) channel subunit; TWIK-related K+ channel 2; outward rectifying potassium channel protein TREK-2; potassium channel TREK-2; potassium channel subfamily K member 10 isoform 1 precursor; potassium channel, subfamily K, member 10; potassium channel, two pore domain subfamily K, member 10; protein phosphatase 1, regulatory subunit 97",
        "tax_id": 9606,
        "disease": "heart conduction disease (Disease Ontology:DOID:10273); brain ischemia (Disease Ontology:DOID:2316)",
        "pathway": " (hsa:54207);  (R-HSA-1299503);  (R-HSA-5576886)",
        "pathway_count": 3,
        "publication_count": 27,
        "publication_id_list": "10880510;11237011;11897838;15795311;16382106;17652773;18516069;19536465;19840997;20133877;20393194;20410120;23481700;25766236;26375851;26919430;28676394;29557506;29632711;29786170;30573346;32488085;34618865;35051231;37296621;38253038;38605031",
        "class_list": "",
        "function": "Beta-COP Suppresses the Surface Expression of the TREK2. Publication Status: Online-Only, [RefSeq, PubMed]; Effects of ionic strength on gating and permeation of TREK-2 K2P channels. Publication Status: Online-Only, [RefSeq, PubMed]; Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2., [RefSeq, PubMed]; K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids (PubMed:10880510, PubMed:25766236, PubMed:26919430, PubMed:38605031). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:30573346). In trigeminal ganglia sensory neurons, the heterodimer of KCNK10/TREK-2 and KCNK18/TRESK inhibits neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (By similarity). Permeable to other monovalent ions such as Rb(+) and Cs(+) (PubMed:26919430)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The M2-glycine hinge controls the macroscopic currents of TREK1 channels., [RefSeq, PubMed]; The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]., [RefSeq]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R8T4;B2RCT3;B5TJL4;Q6B014;Q8TDK7;Q8TDK8;Q9HB59",
        "ec_number_list": "1.8.-.-",
        "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0098782 mechanosensitive potassium channel activity;GO:0005267 potassium channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex",
        "go_biological_process": "GO:0007165 signal transduction;GO:0071805 potassium ion transmembrane transport;GO:1904551 cellular response to arachidonate",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "P57789-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P59773-1",
        "uniprot_id": "MNARL_HUMAN",
        "mass": 21573.0,
        "length": 190,
        "protein_name": "Major intrinsically disordered NOTCH2-binding receptor 1-like",
        "gene_name": "MINAR2",
        "organism": "Human",
        "refseq_name": "major intrinsically disordered NOTCH2-binding receptor 1-like",
        "refseq_ac": "NP_001244237",
        "gene_names_uniprotkb": "MINAR2; KIAA1024L",
        "gene_names_refseq": "DFNB120; KIAA1024L; MINAR2",
        "protein_names_uniprotkb": "Major intrinsically disordered NOTCH2-binding receptor 1-like; Major intrinsically disordered NOTCH2-associated receptor 2; Membrane integral NOTCH2-associated receptor 2",
        "protein_names_refseq": "KIAA1024 like; UPF0258 protein KIAA1024-like; major intrinsically disordered NOTCH2-associated receptor 2; major intrinsically disordered NOTCH2-binding receptor 1-like",
        "tax_id": 9606,
        "disease": "autosomal recessive nonsyndromic deafness (Disease Ontology:DOID:0050565); autosomal recessive nonsyndromic deafness 120 (Disease Ontology:DOID:0070674); Parkinson's disease (Disease Ontology:DOID:14330)",
        "pathway": " (hsa:100127206)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "32954300;35727972;36317962;37245847",
        "class_list": "",
        "function": "Binds cholesterol and may regulate the distribution and homeostasis of cholesterol in hair cells (PubMed:36317962). May play a role in angiogenesis (PubMed:35727972)., [UniProtKB, PubMed, PubMed]; Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity. Erratum:[Mol Metab. 2025 Jul;97:102160. doi: 10.1016/j.molmet.2025.102160. PMID: 40345243], [RefSeq, PubMed]; Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "H3BM78",
        "ec_number_list": "",
        "go_molecular_function": "GO:0015485 cholesterol binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032420 stereocilium",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0042632 cholesterol homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "P59773-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P98153-1",
        "uniprot_id": "IDD_HUMAN",
        "mass": 60811.0,
        "length": 550,
        "protein_name": "Integral membrane protein DGCR2/IDD",
        "gene_name": "DGCR2",
        "organism": "Human",
        "refseq_name": "integral membrane protein DGCR2/IDD isoform 2 precursor",
        "refseq_ac": "NP_001167004",
        "gene_names_uniprotkb": "DGCR2; IDD; KIAA0163",
        "gene_names_refseq": "DGCR2; DGS-C; IDD; LAN; SEZ-12",
        "protein_names_uniprotkb": "Integral membrane protein DGCR2/IDD",
        "protein_names_refseq": "DiGeorge syndrome critical region protein 2; integral membrane protein DGCR2/IDD isoform 2 precursor; integral membrane protein DGCR2/IDD; integral membrane protein deleted in DiGeorge syndrome",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); Alzheimer's disease (Disease Ontology:DOID:10652); generalized anxiety disorder (Disease Ontology:DOID:14320); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); substance abuse (Disease Ontology:DOID:302); panic disorder (Disease Ontology:DOID:594); cocaine abuse (Disease Ontology:DOID:809); subacute delirium (Disease Ontology:DOID:8645)",
        "pathway": " (hsa:9993)",
        "pathway_count": 1,
        "publication_count": 50,
        "publication_id_list": "10.1101/2023.09.13.557529;17081983;19906316;23090970;23186163;24190977;24714562;25502872;25505266;25645385;26992070;27846572;28832583;28834231;29242379;29314611;29393594;29557506;29741879;30315122;30901624;31844290;31848261;32157095;32161166;32350084;32387766;32897882;32938616;33141586;33298915;33392160;33592498;33912179;33936100;34078123;34087483;34171305;34357683;34433824;34561969;35051231;35154160;35251023;36010968;36215666;36241641;37074911;7633403;7655455",
        "class_list": "glycogene",
        "function": "Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]., [RefSeq]; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration., [UniProtKB]; While no association between DGCR2 polymorphisms and schizophrenia was found, the missense variant rs2072123 was associated to left rostral anterior cingulate thickness, showing that DGCR2 seems not to be associated directly with the schizophrenia but might be influencing the brain morphology. We also showed a DGCR2 downregulation in schizophrenia patients when compared to controls and first episode of psychosis., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 688,
        "reported_interactions": 0,
        "missing_score": 9015,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 13,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NIB5;A8K6K5;B5TY34;B7Z935",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030246 carbohydrate binding",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0050890 cognition;GO:0009887 animal organ morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "P98153-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q06033-1",
        "uniprot_id": "ITIH3_HUMAN",
        "mass": 99849.0,
        "length": 890,
        "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H3",
        "gene_name": "ITIH3",
        "organism": "Human",
        "refseq_name": "inter-alpha-trypsin inhibitor heavy chain H3 isoform 4 preproprotein",
        "refseq_ac": "NP_002208",
        "gene_names_uniprotkb": "ITIH3",
        "gene_names_refseq": "H3P; ITI-HC3; ITIH3; SHAP",
        "protein_names_uniprotkb": "Inter-alpha-trypsin inhibitor heavy chain H3; ITI heavy chain H3; ITI-HC3; Inter-alpha-inhibitor heavy chain 3; SHAP; Serum-derived hyaluronan-associated protein",
        "protein_names_refseq": "ITI heavy chain H3; inter-alpha (globulin) inhibitor H3; inter-alpha (globulin) inhibitor, H3 polypeptide; inter-alpha-inhibitor heavy chain 3; inter-alpha-trypsin inhibitor heavy chain H3 isoform 4 preproprotein; inter-alpha-trypsin inhibitor heavy chain H3; pre-alpha (globulin) inhibitor, H3 polypeptide; serum-derived hyaluronan-associated protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3699);  (R-HSA-114608)",
        "pathway_count": 2,
        "publication_count": 42,
        "publication_id_list": "11237011;1435334;14630798;15297306;16335952;1898736;20068231;23090970;23640497;2465147;2476436;28514659;28855257;29314611;29632711;29741879;29992445;30001391;31217245;32161166;32162841;32251353;32350084;32712163;32938616;33392160;33912179;33968037;34357683;34978167;35051231;35251023;35261121;35580925;36010968;36240223;37074911;6457647;7522574;7681778;8467233;9756925",
        "class_list": "",
        "function": "A functional missense variant in ITIH3 affects protein expression and neurodevelopment and confers schizophrenia risk in the Han Chinese population., [RefSeq, PubMed]; A psychiatric disorder risk polymorphism of ITIH3 is associated with multiple neuroimaging phenotypes in young healthy adults., [RefSeq, PubMed]; ITIH3 SNPs rs2535629 and rs736408 were studied in pregnant depressed Japanese women. Neither was related to depressive symptoms during pregnancy.The GCCT haplotype of rs2535629, rs736408, rs3821831, and rs2239547 was significantly positively associated with depressive symptoms during pregnancy., [RefSeq, PubMed]; Integrative analyses indicate an association between ITIH3 polymorphisms with autism spectrum disorder. Publication Status: Online-Only, [RefSeq, PubMed]; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Regulatory Variant rs2535629 in ITIH3 Intron Confers Schizophrenia Risk By Regulating CTCF Binding and SFMBT1 Expression., [RefSeq, PubMed]; This gene encodes the heavy chain subunit of the pre-alpha-trypsin inhibitor complex. This complex may stabilize the extracellular matrix through its ability to bind hyaluronic acid. Polymorphisms of this gene may be associated with increased risk for schizophrenia and major depressive disorder. This gene is present in an inter-alpha-trypsin inhibitor family gene cluster on chromosome 3. [provided by RefSeq, Jul 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 23,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3B7H5;Q53F06;Q6LAM2;Q99085",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0004866 endopeptidase inhibitor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0070062 extracellular exosome;GO:0031089 platelet dense granule lumen",
        "go_biological_process": "GO:0030212 hyaluronan metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "Q06033-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q0VF49-1",
        "uniprot_id": "K2012_HUMAN",
        "mass": 135305.0,
        "length": 1180,
        "protein_name": "Uncharacterized protein KIAA2012",
        "gene_name": "KIAA2012",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "KIAA2012",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Uncharacterized protein KIAA2012",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100652824)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;28832583;30379171;31844290;32488085;33981976;35051231;35494241;35580925",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IVF9",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q0VF49-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14532-1",
        "uniprot_id": "K1H2_HUMAN",
        "mass": 50343.0,
        "length": 448,
        "protein_name": "Keratin, type I cuticular Ha2",
        "gene_name": "KRT32",
        "organism": "Human",
        "refseq_name": "keratin, type I cuticular Ha2",
        "refseq_ac": "NP_002269",
        "gene_names_uniprotkb": "KRT32; HHA2; HKA2; KRTHA2",
        "gene_names_refseq": "HA2; HKA2; KRT32; KRTHA2; hHa2",
        "protein_names_uniprotkb": "Keratin, type I cuticular Ha2; Hair keratin, type I Ha2; K32; Keratin-32",
        "protein_names_refseq": "K32; hair keratin, type I Ha2; hard keratin, type I, 2; keratin 32, type I; keratin, hair, acidic, 2; keratin, type I cuticular Ha2; type I cuticular hair keratin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3882);  (R-HSA-6805567);  (R-HSA-6809371)",
        "pathway_count": 3,
        "publication_count": 52,
        "publication_id_list": "10066784;10196183;10231017;10411887;10588656;10771479;11350120;11380615;11590230;12902340;15033990;15337775;15373777;15797384;15803139;16061697;16382671;16639001;1691188;1694855;1714783;17515931;17521629;17562024;17596512;18843291;19190773;19194479;20179351;20657595;20667819;20940292;21439340;21654840;21997417;23033978;23481192;23629652;2414304;25208914;25926655;26390218;29393594;30192525;7543090;7556444;8823373;8824274;8999895;9395522;9468612;9565599",
        "class_list": "",
        "function": "The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030280 structural constituent of skin epidermis",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0070062 extracellular exosome;GO:0045095 keratin filament",
        "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0008544 epidermis development;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "Q14532-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14573-1",
        "uniprot_id": "ITPR3_HUMAN",
        "mass": 304106.0,
        "length": 2671,
        "protein_name": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3",
        "gene_name": "ITPR3",
        "organism": "Human",
        "refseq_name": "inositol 1,4,5-trisphosphate-gated calcium channel ITPR3",
        "refseq_ac": "NP_002215",
        "gene_names_uniprotkb": "ITPR3",
        "gene_names_refseq": "CMT1J; IMD132; IMD133; IP3R-3; IP3R3; IP3R; ITPR3",
        "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3; IP3 receptor isoform 3; IP3R-3; InsP3R3; Type 3 InsP3 receptor; Type 3 inositol 1,4,5-trisphosphate receptor",
        "protein_names_refseq": "IP3 receptor; inositol 1,4,5-triphosphate receptor, type 3; inositol 1,4,5-trisphosphate-gated calcium channel ITPR3; insP3R3; type 3 InsP3 receptor",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); immunodeficiency 133 (Disease Ontology:DOID:0061096); pre-eclampsia (Disease Ontology:DOID:10591); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); gestational diabetes (Disease Ontology:DOID:11714); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441); obesity (Disease Ontology:DOID:9970); Charcot-Marie-Tooth disease, demyelinating, type 1J (MONDO:MONDO:0859311)",
        "pathway": " (hsa:3710);  (R-HSA-111996);  (R-HSA-112043);  (R-HSA-114508);  (R-HSA-139853);  (R-HSA-1489509);  (R-HSA-2029485);  (R-HSA-2871809);  (R-HSA-381676);  (R-HSA-4086398);  (R-HSA-422356);  (R-HSA-5218921);  (R-HSA-5578775);  (R-HSA-5607763);  (R-HSA-9664323);  (R-HSA-9717207);  (R-HSA-983695)",
        "pathway_count": 17,
        "publication_count": 480,
        "publication_id_list": "10.1101/2023.09.13.557529;10051622;10194514;10206966;10220561;10224668;10318832;10342826;10380924;10391246;10391247;10395542;10421574;10424882;10432293;10488343;10498607;10526167;10556826;10579907;10588714;10648173;10706702;10761935;10770799;10773014;10777564;10802064;1081164;10858654;10860980;10861086;10866047;10868950;10880360;10913253;10983984;11015615;11015619;11030334;11042164;11062458;11071853;11071869;11078440;11078469;11080611;11118617;11226282;11264248;11387210;11395409;11413485;11425868;11449366;11563835;11577798;11600407;11606584;11716850;11749377;11780755;11805119;11815450;11815460;11815462;11815463;11873862;11901194;11904675;11909947;11917125;12015605;12015988;12032348;12034449;12086864;12117970;12119109;12180908;12181444;12196472;12391145;12401793;12403834;12410638;12417718;12453414;12456653;12471263;12475777;12475787;12482967;12496249;12556497;12573241;12660731;12684222;12729560;12764427;12776187;12832055;12840507;12869549;12887316;12938160;12953268;12975316;1309948;1322796;1325650;13459201;13680124;1372004;1372019;1374290;1375264;1376928;14514350;14532121;14634208;14704854;14977528;14988243;15000528;15161916;15174025;15187135;15260953;15294978;15305887;15353592;15385606;15494017;15504896;1550550;15509800;15536084;15545263;15569269;15572341;15585596;15598648;15611108;15678092;15738140;15754088;15809313;15879121;15879134;15955806;1599430;15995848;16332676;16443778;16497229;16513675;16556766;16613879;16678913;16714477;16754674;16849466;16861033;16868246;16880514;16906149;16920709;16921024;1693919;16973695;17021801;1702903;1705565;17081983;17095603;17167479;17224452;17259518;17306374;17357072;17380317;17426020;17444618;17452328;17486119;17502104;17506496;17547437;17590538;17660294;17684012;17900700;17919183;18006696;18025150;18052078;18070890;18162464;18187424;18202100;18287102;18296442;18326500;18346985;18412318;18420269;18452278;18456304;18488142;18577758;18578522;18596693;18596924;18669648;18767875;18818202;18826956;18843204;18995841;19033211;19104071;19177143;19206206;19249086;19278978;19372136;19536106;19553469;19587354;19664994;19690332;19691289;19696921;19751721;19851316;19859570;19861722;20022913;20033988;20058876;20068231;20086079;2011584;20192804;20388710;20807769;21037092;21108950;21118996;21383013;21408196;21422378;21469132;2175712;21795555;21822214;21903638;22180443;22210847;2226863;22427649;22707725;22941947;22972900;2303036;2304550;23151663;23186163;23256519;23362265;23416699;23481700;23549614;23610579;23632248;23632330;23675550;23904219;23936024;23992284;24157691;24190977;24214976;24275569;2430951;24360415;2457808;24627108;24633359;24715725;2477373;25418920;25505266;25576301;2559024;25645385;25853419;25892735;25994790;25996873;26308095;26377607;26517901;26590425;26992070;27600516;27846572;27862975;27920218;27995898;28063628;28218747;28228285;28256214;2838329;2841328;28514659;28645727;28832583;28904123;29108130;29242379;29371260;29437277;29466837;29508533;2953725;29557506;29632046;29632711;29659026;29744740;29769354;29786170;30013099;30315122;30379171;30410026;30429286;30563861;30620550;30779550;30833945;31067468;31154438;31217245;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32938616;32949214;32983136;33141586;33298915;33537174;33592498;33633747;33717175;33912179;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34405274;34509645;34932366;3500860;35051231;35154160;3517644;35301323;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36302985;36350267;36471115;37898605;3923453;39270020;39560673;40596516;4589993;6019353;6328127;6335036;6424440;6435940;7517665;7518558;7522622;7524079;7528218;7530449;7538118;7589461;7589840;7592958;7593639;7641683;7687428;7687539;7688784;7691807;7702581;7720699;7927516;7929371;7929812;8027028;803528;8081734;8138058;8163536;8226994;8228618;8288584;8306975;8340414;8404634;8405712;8457197;8629002;8630736;8631904;8646775;8657103;8675920;8798450;8799126;8830891;8862523;8918259;8947047;8987985;8997178;9000504;9042338;9050880;9065781;9073455;9162098;9218480;9235916;9314552;9326643;9341187;9346285;9350615;9382888;9389482;9417641;9488697;9565569;9601053;9697839;9705962;9726229;9739505;9751501;9857068;9889098;9914469;9920805;9930701;9973503",
        "class_list": "",
        "function": "A pleiotropic recurrent dominant ITPR3 variant causes a complex multisystemic disease., [RefSeq, PubMed]; Disrupted Ca[2+] homeostasis and immunodeficiency in patients with functional IP3 receptor subtype 3 defects. Erratum:[Cell Mol Immunol. 2023 Jan;20(1):114. doi: 10.1038/s41423-022-00960-4. PMID: 36471115], [RefSeq, PubMed]; Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population., [RefSeq, PubMed]; Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis (PubMed:32949214, PubMed:37898605, PubMed:8081734, PubMed:8288584, PubMed:39560673). 1D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state (PubMed:30013099, PubMed:35301323, PubMed:37898605). Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release (PubMed:30013099, PubMed:35301323, PubMed:37898605)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 88,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 8,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14649;Q5TAQ2",
        "ec_number_list": "2.7.11.1",
        "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding",
        "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0051289 protein homotetramerization;GO:0051592 response to calcium ion;GO:0030168 platelet activation",
        "synthesized_glycan_count": 0,
        "hit_score": 48.7,
        "record_id": "Q14573-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q16773-1",
        "uniprot_id": "KAT1_HUMAN",
        "mass": 47875.0,
        "length": 422,
        "protein_name": "Kynurenine--oxoglutarate transaminase 1",
        "gene_name": "KYAT1",
        "organism": "Human",
        "refseq_name": "kynurenine--oxoglutarate transaminase 1 isoform a",
        "refseq_ac": "NP_001116143",
        "gene_names_uniprotkb": "KYAT1; CCBL1",
        "gene_names_refseq": "CCBL1; GTK; KAT1; KATI; KYAT1",
        "protein_names_uniprotkb": "Kynurenine--oxoglutarate transaminase 1; 2.6.1.64; 2.6.1.7; 4.4.1.13; Cysteine-S-conjugate beta-lyase; GTK; Glutamine transaminase K; Glutamine--phenylpyruvate transaminase; KATI; Kynurenine aminotransferase 1; Kynurenine aminotransferase I; Kynurenine--oxoglutarate transaminase I",
        "protein_names_refseq": "beta-lysase, kidney; cysteine conjugate beta lyase 1; cysteine conjugate-beta lyase, cytoplasmic; cysteine conjugate-beta lyase; cysteine-S-conjugate beta-lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase); glutamine transaminase K; glutamine--phenylpyruvate transaminase; glutamine-phenylpyruvate aminotransferase; kyneurenine aminotransferase; kynurenine aminotransferase I; kynurenine--oxoglutarate transaminase 1 isoform a; kynurenine--oxoglutarate transaminase 1; kynurenine--oxoglutarate transaminase I",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:883);  (R-HSA-71240);  (R-HSA-8964208);  (R-HSA-8964539)",
        "pathway_count": 4,
        "publication_count": 68,
        "publication_id_list": "10049700;10391915;10672018;11237011;11903050;12007602;12054821;12140278;13069505;15364907;15880762;16267323;16376499;16477023;16730026;17356132;1737786;17671174;18005987;18056995;18262359;18620547;19338303;19648921;19839645;20068231;20657015;21097500;22861376;22891768;23024808;23478338;24768817;25865492;26902786;2722838;28097769;28218747;28514659;28706436;28904123;29242379;29437277;29769354;3033643;31231915;31422819;31844290;33592498;33691108;33912179;33968037;36241641;4052435;429360;6819292;7514594;7744010;7883047;8262916;8294935;8352282;8444860;8666386;8889590;9180257;9514741;9642259",
        "class_list": "",
        "function": "Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others (PubMed:19338303, PubMed:28097769). Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites (PubMed:7883047). Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:7883047)., [UniProtKB, PubMed, PubMed, PubMed]; Genetic suppression of glutamine transaminase K (GTK), a key enzyme of the glutaminase II pathway, leads to the complete inhibition of pancreatic tumorigenesis in vivo unveiling GTK as a new metabolic target for cancer therapy, [RefSeq, PubMed]; Immunohistochemical analysis revealed the presence of KAT I, II, and III in all examined corneal sections. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T275;Q8N191",
        "ec_number_list": "2.6.1.7;2.6.1.1;2.6.1.64;4.4.1.13;2.6.1.63;2.6.1.39;2.6.1.4;2.6.1.73",
        "go_molecular_function": "GO:0047316 glutamine-phenylpyruvate transaminase activity;GO:0016212 kynurenine-oxoglutarate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0042803 protein homodimerization activity;GO:0047804 cysteine-S-conjugate beta-lyase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:0097053 L-kynurenine catabolic process;GO:0070189 kynurenine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "Q16773-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5JU85-2",
        "uniprot_id": "IQEC2_HUMAN",
        "mass": 162784.0,
        "length": 1488,
        "protein_name": "IQ motif and SEC7 domain-containing protein 2",
        "gene_name": "IQSEC2",
        "organism": "Human",
        "refseq_name": "IQ motif and SEC7 domain-containing protein 2 isoform 1",
        "refseq_ac": "NP_001104595",
        "gene_names_uniprotkb": "IQSEC2; KIAA0522",
        "gene_names_refseq": "BRAG1; IQ-ArfGEF; IQSEC2; MRX18; MRX1; MRX78; NEDXSB; XLID1",
        "protein_names_uniprotkb": "IQ motif and SEC7 domain-containing protein 2",
        "protein_names_refseq": "IQ motif and SEC7 domain-containing protein 2 isoform 1; IQ motif and SEC7 domain-containing protein 2; IQ motif and Sec7 domain 2; brefeldin A resistant Arf-guanine nucleotide exchange factor 1b; brefeldin A resistant Arf-guanine nucleotide exchange factor 1c",
        "tax_id": 9606,
        "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); non-syndromic X-linked intellectual disability 1 (Disease Ontology:DOID:0112038)",
        "pathway": " (hsa:23096)",
        "pathway_count": 1,
        "publication_count": 32,
        "publication_id_list": "10.1101/2023.09.13.557529;19615748;20473311;21406692;23186163;26793055;28904123;29393594;29557506;30379171;31844290;32157095;32357974;32387766;32488085;32938616;32983136;33123756;33592498;33968037;34509645;34561969;34932366;35051231;35561310;35580925;36010968;36241641;36284347;36902414;37078745;37787765",
        "class_list": "",
        "function": "Ca2+-induced release of IQSEC2/BRAG1 autoinhibition under physiological and pathological conditions., [RefSeq, PubMed]; Here we show that a mutation of IQSEC2, encoding a guanine nucleotide exchange factor for the ADP-ribosylation factor family of small GTPases, caused this disorder, [RefSeq, PubMed]; Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins., [UniProtKB, PubMed]; Molecular Insights into IQSEC2 Disease. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Molecular modeling of ARF6 dysregulation caused by mutations in IQSEC2., [RefSeq, PubMed]; This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A1W2PQN3;B3KT97;C7SDG1;O60275;Q5JUX1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0098839 postsynaptic density membrane;GO:0098685 Schaffer collateral - CA1 synapse",
        "go_biological_process": "GO:0051968 positive regulation of synaptic transmission, glutamatergic;GO:0051965 positive regulation of synapse assembly;GO:0016192 vesicle-mediated transport;GO:0050804 modulation of chemical synaptic transmission;GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "Q5JU85-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6GPH6-1",
        "uniprot_id": "IPIL1_HUMAN",
        "mass": 63395.0,
        "length": 555,
        "protein_name": "Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1",
        "gene_name": "ITPRIPL1",
        "organism": "Human",
        "refseq_name": "inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 isoform 2",
        "refseq_ac": "NP_001008949",
        "gene_names_uniprotkb": "ITPRIPL1; KIAA1754L",
        "gene_names_refseq": "D1B; ITPRIPL1; KIAA1754L",
        "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1",
        "protein_names_refseq": "DANGER family member 1B; inositol 1,4,5-triphosphate receptor-interacting protein-like 1; inositol 1,4,5-trisphosphate receptor interacting protein-like 1; inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:150771)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "11237011;23481700;24366607;25418920;26154972;26992070;27846572;27920218;28218747;28228285;28832583;28834231;28904123;29242379;29393594;31530632;31844290;32357974;32502341;32897882;32938616;32983136;33298915;33717175;33912179;38614099",
        "class_list": "",
        "function": "Functions as a ligand of CD3E, inhibiting TCR-CD3 complex signaling to regulate T cell activation. Induces stable CD3E-NCK1 binding, thereby preventing the CD3E-ZAP70 interaction and subsequently inhibiting the activation of the downstream ERK-NFkB signaling cascade and calcium influx., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F5H1L8;Q8NE61",
        "ec_number_list": "",
        "go_molecular_function": "GO:0048018 receptor ligand activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0050860 negative regulation of T cell receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "Q6GPH6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6NSI8-1",
        "uniprot_id": "SANBR_HUMAN",
        "mass": 82007.0,
        "length": 718,
        "protein_name": "SANT and BTB domain regulator of class switch recombination",
        "gene_name": "SANBR",
        "organism": "Human",
        "refseq_name": "SANT and BTB domain regulator of class switch recombination isoform a",
        "refseq_ac": "NP_001123465",
        "gene_names_uniprotkb": "SANBR; KIAA1841",
        "gene_names_refseq": "KIAA1841; SANBR",
        "protein_names_uniprotkb": "SANT and BTB domain regulator of class switch recombination; SANT and BTB domain regulator of CSR",
        "protein_names_refseq": "SANT and BTB domain regulator of class switch recombination isoform a; SANT and BTB domain regulator of class switch recombination",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84542)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11237011;23481700;25576301;27600516;28832583;28904123;29242379;29632046;30379171;30429286;31092671;31217245;31530632;31844290;32157095;32502341;33298915;33592498",
        "class_list": "",
        "function": "Negatively regulates class switch recombination or isotype switching in splenic B-cells., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q49AF0;Q6ZND0;Q96JI6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "",
        "go_biological_process": "GO:0045190 isotype switching",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q6NSI8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZMT4-1",
        "uniprot_id": "KDM7A_HUMAN",
        "mass": 106557.0,
        "length": 941,
        "protein_name": "Lysine-specific demethylase 7A",
        "gene_name": "KDM7A",
        "organism": "Human",
        "refseq_name": "lysine-specific demethylase 7A",
        "refseq_ac": "NP_085150",
        "gene_names_uniprotkb": "KDM7A; JHDM1D; KDM7; KIAA1718",
        "gene_names_refseq": "JHDM1D; KDM7A",
        "protein_names_uniprotkb": "Lysine-specific demethylase 7A; 1.14.11.65; JmjC domain-containing histone demethylation protein 1D; Lysine-specific demethylase 7; [histone H3]-dimethyl-L-lysine9 demethylase 7A",
        "protein_names_refseq": "[histone H3]-dimethyl-L-lysine9 demethylase 7A; histone lysine demethylase JHDM1D; jmjC domain-containing histone demethylation protein 1D; jumonji C domain containing histone demethylase 1 homolog D; lysine (K)-specific demethylase 7A; lysine-specific demethylase 7A; lysine-specific demethylase 7",
        "tax_id": 9606,
        "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); melanoma (Disease Ontology:DOID:1909)",
        "pathway": " (hsa:80853);  (R-HSA-3214842);  (R-HSA-6802952)",
        "pathway_count": 3,
        "publication_count": 70,
        "publication_id_list": "11237011;15620353;15630448;16362057;16603237;16603238;16732292;16732293;16738407;17310255;17320163;17351631;17713478;17947579;18452278;18974108;19502796;19727073;19843542;20023638;20084082;20129925;20208542;20457893;20526349;20622853;20622854;21424530;21532585;22143793;22615488;22745804;23186163;23583981;24135138;24345920;25204415;25645385;25907612;26154972;26992070;27600516;27862975;28228285;28832583;28834231;29242379;29393594;29493099;29557506;29563586;29632046;31217245;31844290;31848261;32125007;32157095;32357974;32781788;32935279;32938616;32983136;33245963;33592498;33968037;34087483;35051231;35580925;36010968;39273051",
        "class_list": "",
        "function": "Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells., [RefSeq, PubMed]; Histone Demethylase KDM7A Regulates Androgen Receptor Activity, and Its Chemical Inhibitor TC-E 5002 Overcomes Cisplatin-Resistance in Bladder Cancer Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (PubMed:20023638, PubMed:20622853). Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3 (PubMed:20023638). Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (PubMed:20622853)., [UniProtKB, PubMed, PubMed]; Increased JHDM1D expression suppresses tumor growth by down-regulating angiogenesis under nutrient starvation, [RefSeq, PubMed]; Inhibition of KDM2/7 Promotes Notochordal Differentiation of hiPSCs. Publication Status: Online-Only, [RefSeq, PubMed]; JHDM1D-AS1 aggravates the development of gastric cancer through miR-450a-2-3p-PRAF2 axis., [RefSeq, PubMed]; KIAA1718 is a dual-specificity histone demethylase that regulates neural differentiation through FGF4. Erratum:[Cell Res. 2025 Oct;35(10):779-780. doi: 10.1038/s41422-025-01143-2. PMID: 40640644], [RefSeq, PubMed]; The nuclear bodies formed by histone demethylase KDM7A., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D1S9;C9JJH9;C9JQU2;Q6MZL8;Q9C0E5",
        "ec_number_list": "1.14.11.68;2.3.2.27;1.14.11.65;1.14.11.-;1.14.99.66;2.7.10.2;3.6.5.2;2.7.11.1;2.7.11.24;2.7.12.2;2.7.10.4;3.6.4.-;2.7.11.17;2.7.1.107;2.7.1.94;2.7.1.138;2.7.7.-;2.7.7.19;3.1.31.1",
        "go_molecular_function": "GO:0035575 histone H4K20 demethylase activity;GO:0051864 histone H3K36 demethylase activity;GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0030901 midbrain development",
        "synthesized_glycan_count": 0,
        "hit_score": 7.1,
        "record_id": "Q6ZMT4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IU85-1",
        "uniprot_id": "KCC1D_HUMAN",
        "mass": 42914.0,
        "length": 385,
        "protein_name": "Calcium/calmodulin-dependent protein kinase type 1D",
        "gene_name": "CAMK1D",
        "organism": "Human",
        "refseq_name": "calcium/calmodulin-dependent protein kinase type 1D isoform 1",
        "refseq_ac": "NP_065130",
        "gene_names_uniprotkb": "CAMK1D; CAMKID",
        "gene_names_refseq": "CAMK1D; CKLiK; CaM-K1; CaMKID",
        "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type 1D; 2.7.11.17; CKLiK; CaM kinase I delta; CaM kinase ID; CaM-KI delta; CaMKI delta; CaMKI-like protein kinase; CaMKID",
        "protein_names_refseq": "CAMK1D/ANAPC5 fusion; CaM kinase ID; CamKI-like protein kinase; caM kinase I delta; caM-KI delta; caMKI delta; calcium/calmodulin-dependent protein kinase type 1D isoform 1; calcium/calmodulin-dependent protein kinase type 1D",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57118)",
        "pathway_count": 1,
        "publication_count": 68,
        "publication_id_list": "11050006;12935886;15840691;16324104;17056143;17344846;18669648;18817731;18991276;22645359;23301498;23481700;24714562;25218447;25576301;26154972;26375851;26728094;26992070;28218747;28228285;28657654;28832583;28834231;28855257;28904123;29242379;29393594;29437277;29485866;29493099;29508533;29557506;29632711;29786170;29789417;30410026;30429286;30524438;30833945;31154438;31217245;31492838;31844290;31848261;32161166;32357974;32387766;32488085;32502341;32665263;32897882;32983136;33123756;33127268;33298915;33633747;33660800;33691108;33717175;33912179;34932366;35051231;35254053;35580925;36010968;36284347;37938771",
        "class_list": "",
        "function": "Associations of SUCNR1, GRK4, CAMK1D gene polymorphisms and the susceptibility of type 2 diabetes mellitus and essential hypertension in a northern Chinese Han population., [RefSeq, PubMed]; CAMK1D Triggers Immune Resistance of Human Tumor Cells Refractory to Anti-PD-L1 Treatment., [RefSeq, PubMed]; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; CircPRKCI regulates proliferation, migration and cycle of lung adenocarcinoma cells by targeting miR-219a-5p-regulated CAMK1D., [RefSeq, PubMed]; Role of CKLiK in specific granulocyte effector functions such as phagocytosis, respiratory burst, migration, and adhesion, [RefSeq, PubMed]; This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jan 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0YIY0;Q9HD31",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0071622 regulation of granulocyte chemotaxis;GO:0006954 inflammatory response;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development",
        "synthesized_glycan_count": 0,
        "hit_score": 7.1,
        "record_id": "Q8IU85-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IYS2-1",
        "uniprot_id": "K2013_HUMAN",
        "mass": 69157.0,
        "length": 634,
        "protein_name": "Uncharacterized protein KIAA2013",
        "gene_name": "KIAA2013",
        "organism": "Human",
        "refseq_name": "uncharacterized protein KIAA2013 precursor",
        "refseq_ac": "NP_612355",
        "gene_names_uniprotkb": "KIAA2013",
        "gene_names_refseq": "KIAA2013",
        "protein_names_uniprotkb": "Uncharacterized protein KIAA2013",
        "protein_names_refseq": "RP5-1077B9.1; uncharacterized protein KIAA2013 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:90231)",
        "pathway_count": 1,
        "publication_count": 65,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;23584533;24714562;25502872;25576301;25813380;25880248;26728094;26811146;26992070;27600516;27846572;27862975;28218747;28228285;28467828;28832583;28904123;29242379;29437277;29493099;29557506;29632711;29786170;30315122;30410026;30429286;30524438;30573663;31154438;31217245;31844290;31848261;32157095;32161166;32265295;32350084;32357974;32387766;32897882;32938616;32983136;33298915;33392160;33592498;33912179;33936100;33968037;34171305;34185709;34357683;34932366;35051231;35132862;35154160;35251023;35318648;35561310;35580925;35705054;36284347;37938771;40307207;40596516",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5JXC1;Q8IVF8;Q8NDI7;Q9BSY1",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 7.3,
        "record_id": "Q8IYS2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N0W5-1",
        "uniprot_id": "IQCK_HUMAN",
        "mass": 33292.0,
        "length": 287,
        "protein_name": "IQ domain-containing protein K",
        "gene_name": "IQCK",
        "organism": "Human",
        "refseq_name": "IQ domain-containing protein K isoform 2",
        "refseq_ac": "NP_001292050",
        "gene_names_uniprotkb": "IQCK",
        "gene_names_refseq": "IQCK",
        "protein_names_uniprotkb": "IQ domain-containing protein K",
        "protein_names_refseq": "IQ domain-containing protein K isoform 2; IQ domain-containing protein K",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:124152)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "11237011;15302935;20628086;25418920;25576301;26154972;29242379;30315122;30379171;31154438;31844290;31848261;32157095;32161166;33298915;34171305",
        "class_list": "",
        "function": "Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; This gene belongs to the IQ motif-containing family of proteins. The IQ motif serves as a binding site for different EF-hand proteins such as calmodulin. This gene was identified as a potential candidate gene for obsessive-compulsive disorder in a genome-wide association study. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDU0;O43327;Q8NFF4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q8N0W5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N371-1",
        "uniprot_id": "KDM8_HUMAN",
        "mass": 47270.0,
        "length": 416,
        "protein_name": "Bifunctional peptidase and arginyl-hydroxylase JMJD5",
        "gene_name": "KDM8",
        "organism": "Human",
        "refseq_name": "bifunctional peptidase and arginyl-hydroxylase JMJD5 isoform 1",
        "refseq_ac": "NP_001138820",
        "gene_names_uniprotkb": "KDM8; JMJD5",
        "gene_names_refseq": "JMJD5; KDM8",
        "protein_names_uniprotkb": "Bifunctional peptidase and arginyl-hydroxylase JMJD5; 1.14.11.73; 3.4.-.-; JmjC domain-containing protein 5; Jumonji C domain-containing protein 5; L-arginine (3R)-hydroxylase KDM8",
        "protein_names_refseq": "JmjC arginyl-hydroxylase; L-arginine (3R)-hydroxylase KDM8; arginyl C3-hydroxylase KDM8; bifunctional peptidase and arginyl-hydroxylase JMJD5 isoform 1; bifunctional peptidase and arginyl-hydroxylase JMJD5; jmjC domain-containing protein 5; jumonji C domain-containing protein 5; jumonji domain containing 5; jumonji domain-containing protein 5; lysine (K)-specific demethylase 8; lysine-specific demethylase 8",
        "tax_id": 9606,
        "disease": "breast cancer (Disease Ontology:DOID:1612)",
        "pathway": " (hsa:79831);  (R-HSA-9629569)",
        "pathway_count": 2,
        "publication_count": 56,
        "publication_id_list": "11237011;1378441;15676025;16858412;17947579;1856229;19574390;19819225;20457893;20684070;21060799;21115819;22375008;22851697;23103944;23303181;23481700;24100311;24486019;24550447;24550462;24550463;24740926;24981860;25728928;26154972;26992070;28455245;28847961;28982940;29459673;29563586;29914368;29915238;30429286;30500822;31844290;32157095;32357974;32387766;32502341;32747552;32938616;33141586;33298915;33392160;33912179;33968037;34211107;34509645;35051231;35176452;35580925;36284347;37813845;6688526",
        "class_list": "",
        "function": "Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase (PubMed:28847961, PubMed:28982940, PubMed:29459673, PubMed:29563586). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961, PubMed:28982940, PubMed:29459673). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961, PubMed:29459673). Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage (PubMed:28982940). Additionally, acts as a Fe(2+) and 2-oxoglutarate-dependent monooxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established (PubMed:29563586). Regulates mitosis through different mechanisms: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1. Possibly together with RCCD1, is involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Negatively regulates cell cycle repressor CDKN1A/p21, which controls G1/S phase transition (PubMed:24740926). Required for G2/M phase cell cycle progression. Regulates expression of CCNA1/cyclin-A1, leading to cancer cell proliferation (PubMed:20457893). Also, plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability involved in epithelial to mesenchymal transition (PubMed:28455245). Regulates the circadian gene expression in the liver (By similarity). Represses the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a catalytically-independent manner (PubMed:30500822). Negatively regulates the protein stability and function of CRY1; required for AMPK-FBXL3-induced CRY1 degradation (PubMed:30500822)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Data show that both Arabidopsis jmjd5 mutant seedlings and mammalian cell cultures deficient for the human ortholog of this gene have similar fast-running circadian oscillations compared with WT., [RefSeq, PubMed]; Identifies five novel candidate tumor suppressor genes in mouse, including Pou2f2, Hivep3, Jmjd5, Fbxl10 and a protein similar to human N4BP3., [RefSeq, PubMed]; JMJD5 couples with CDK9 to release the paused RNA polymerase II., [RefSeq, PubMed]; JMJD5 inhibits lung cancer progression by facilitating EGFR proteasomal degradation. Publication Status: Online-Only, [RefSeq, PubMed]; JMJD5 is a post-translational co-repressor for NFATc1 that attenuates osteoclastogenesis., [RefSeq, PubMed]; Jumonji-C domain-containing protein 5 suppresses proliferation and aerobic glycolysis in pancreatic cancer cells in a c-Myc-dependent manner., [RefSeq, PubMed]; Show that JMJD5 (now renamed KDM8), demethylates H3K36me2 and is required for cell cycle progression., [RefSeq, PubMed]; This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 15,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DLU9;Q6VAK5;Q9H8B1",
        "ec_number_list": "3.4.-.-;1.14.11.73",
        "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0003682 chromatin binding;GO:0004175 endopeptidase activity;GO:0046872 metal ion binding;GO:0004177 aminopeptidase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005694 chromosome",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0000086 G2/M transition of mitotic cell cycle;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 5.7,
        "record_id": "Q8N371-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NFY9-1",
        "uniprot_id": "KBTB8_HUMAN",
        "mass": 68823.0,
        "length": 601,
        "protein_name": "Kelch repeat and BTB domain-containing protein 8",
        "gene_name": "KBTBD8",
        "organism": "Human",
        "refseq_name": "kelch repeat and BTB domain-containing protein 8",
        "refseq_ac": "NP_115894",
        "gene_names_uniprotkb": "KBTBD8; KIAA1842; TAKRP",
        "gene_names_refseq": "KBTBD8; TA-KRP; TAKRP",
        "protein_names_uniprotkb": "Kelch repeat and BTB domain-containing protein 8; T-cell activation kelch repeat protein; TA-KRP",
        "protein_names_refseq": "T-cell activation kelch repeat protein; kelch repeat and BTB (POZ) domain containing 8; kelch repeat and BTB domain-containing protein 8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84541);  (R-HSA-8951664);  (R-HSA-983168)",
        "pathway_count": 3,
        "publication_count": 154,
        "publication_id_list": "10535940;10597293;10811609;10878807;10973499;11062501;11069780;11237011;11259415;11292861;11292862;11350924;11454738;11585840;11733065;11961546;12101228;12186903;12504025;12504026;12526791;12538644;12609982;12646216;12682069;12759363;12816948;14690597;14734113;14757770;15224091;15224092;15282312;15361859;15367669;15537541;15571818;15572695;15574592;15601839;15652483;15688063;15694336;15799966;16171779;16401342;16547496;16595681;16647857;16707496;16790436;16849449;16943200;16954532;16959974;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18093314;18206966;18662542;18775313;18776931;18805092;18826954;18851830;18926707;19028597;19250909;19321346;19352404;19452197;19489725;19617556;19748355;19851334;19874575;19893584;19940261;21447816;21463634;21778237;21863050;21940857;22306028;22466964;22537386;2261476;22959436;23201271;23333871;23401859;23453757;23481700;23535662;23535663;23563313;23578279;23583660;23912815;23986495;24076655;24366543;24636985;24793695;24793696;25314029;25349211;25355947;25531226;26344709;26399832;26460955;26632597;26906416;27030794;27222660;27565346;27846572;28115426;28228285;28489076;28832583;29153394;29242379;29557506;29769354;29999490;30315122;30610225;30833945;31844290;32005965;32284348;32350084;32357974;32502341;33109073;33444648;33691108;33981976;34171305;35051231;35580925;36010968;9380723;9668046;9790970;9887101;9891082",
        "class_list": "",
        "function": "Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832)., [UniProtKB, PubMed]; The authors found that CUL3 complexed with KBTBD8 monoubiquitylates its essential targets only after these have been phosphorylated in multiple motifs by CK2, a kinase whose levels gradually increase during embryogenesis. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DTW6;Q96JI5",
        "ec_number_list": "",
        "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005819 spindle;GO:0005829 cytosol;GO:0031463 Cul3-RING ubiquitin ligase complex",
        "go_biological_process": "GO:0014029 neural crest formation;GO:0006417 regulation of translation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0014032 neural crest cell development;GO:0006513 protein monoubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 15.5,
        "record_id": "Q8NFY9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NI17-1",
        "uniprot_id": "IL31R_HUMAN",
        "mass": 82954.0,
        "length": 732,
        "protein_name": "Interleukin-31 receptor subunit alpha",
        "gene_name": "IL31RA",
        "organism": "Human",
        "refseq_name": "interleukin-31 receptor subunit alpha isoform 2 precursor",
        "refseq_ac": "NP_001229565",
        "gene_names_uniprotkb": "IL31RA; CRL3; GPL; PRO21384",
        "gene_names_refseq": "CRL3; CRL; GLM-R; GLMR; GPL; IL-31RA; IL31RA; PLCA2; PRO21384; hGLM-R; zcytoR17",
        "protein_names_uniprotkb": "Interleukin-31 receptor subunit alpha; Cytokine receptor-like 3; GLM-R; GPL; Gp130-like monocyte receptor; Gp130-like receptor; IL-31 receptor A; IL-31 receptor subunit alpha; IL-31R subunit alpha; IL-31R-alpha; IL-31RA; ZcytoR17; hGLM-R",
        "protein_names_refseq": "IL-31 receptor subunit alpha; IL-31R subunit alpha; class I cytokine receptor; cytokine receptor-like 3; gp130-like monocyte receptor; interleukin-31 receptor subunit alpha isoform 2 precursor; soluble type I cytokine receptor CRL3",
        "tax_id": 9606,
        "disease": "primary localized cutaneous amyloidosis 2 (Disease Ontology:DOID:0080931)",
        "pathway": " (hsa:133396);  (R-HSA-6788467)",
        "pathway_count": 2,
        "publication_count": 50,
        "publication_id_list": "10586060;10812968;10966616;11237011;11834704;11877449;11943154;12601009;12707266;12811586;12975309;14504285;15184896;15194700;15340161;15450249;15519241;15627637;16051226;16461143;18439099;19690585;19920145;21261663;21715184;24373353;2779549;28408397;29557506;31844290;32157095;32387766;32459958;33968037;34642338;35051231;35580925;36651089;38081868;7670098;7738033;7852997;7862649;7957045;8119965;8272873;8390097;8627290;8637716;9238703",
        "class_list": "",
        "function": "A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5., [RefSeq, PubMed]; Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro., [UniProtKB, UniProtKB]; Feline Interleukin-31 Shares Overlapping Epitopes with the Oncostatin M Receptor and IL-31RA., [RefSeq, PubMed]; Functions as a membrane-bound signal-transducing subunit of the IL31 receptor complex (heterodimer composed of OSMR and IL31RA) which binds IL31 (PubMed:15184896, PubMed:15194700, PubMed:15627637). Functionally, IL31 signaling via OSMR/IL31RA is particularly important in skin immunity (PubMed:15184896). Mechanistically, ligand binding induces heterodimerization with OSMR, activating JAK1 and JAK2 (and to a lesser extent TYK2) associated with the intracellular domains of IL31RA and OSMR (PubMed:15194700, PubMed:15627637). These kinases phosphorylate tyrosine residues on IL31RA and OSMR, creating docking sites for STAT1, STAT3, and STAT5B, which are then phosphorylated and activated (Probable) (PubMed:11877449, PubMed:15194700, PubMed:15627637). In addition, the IL31 receptor complex activates the MAPK pathway (MAPK3/ERK1-MAPK1/ERK2) via recruitment of the adapter protein SHC1 (PubMed:15194700, PubMed:15627637). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; GPL is a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor, [RefSeq, PubMed]; IL-31 and IL-31 receptor alpha in pemphigus: Contributors to more than just itch?, [RefSeq, PubMed]; Interleukin 31 receptor alpha promotes smooth muscle cell contraction and airway hyperresponsiveness in asthma. Publication Status: Online-Only, [RefSeq, PubMed]; Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis. Publication Status: Online-Only, [RefSeq, PubMed]; The first demonstration of the involvement of the IL-31/IL-31R axis in cancer came from studies in patients with mycosis fungoides/Sezary syndrome, the most frequent, cutaneous T cell lymphoma. Tumor cells were shown to produce IL-31, whose serum levels correlated with pruritus intensity. Review article, [RefSeq, PubMed]; The molecular mechanisms underlying GPL-mediated signal transduction, [RefSeq, PubMed]; The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]., [RefSeq]",
        "predicted_glycosites": 9,
        "predicted_n_glycosites": 8,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NIF8;Q2TBA1;Q6EBC3;Q6EBC4;Q6EBC5;Q6EBC6;Q6UWL8;Q8WYJ0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019901 protein kinase binding;GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0006952 defense response;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0000165 MAPK cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q8NI17-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q3SY84-1",
        "uniprot_id": "K2C71_HUMAN",
        "mass": 57292.0,
        "length": 523,
        "protein_name": "Keratin, type II cytoskeletal 71",
        "gene_name": "KRT71",
        "organism": "Human",
        "refseq_name": "keratin, type II cytoskeletal 71",
        "refseq_ac": "NP_258259",
        "gene_names_uniprotkb": "KRT71; K6IRS1; KB34; KRT6IRS1",
        "gene_names_refseq": "HYPT13; K6IRS1; KRT6IRS1; KRT6IRS; KRT71",
        "protein_names_uniprotkb": "Keratin, type II cytoskeletal 71; CK-71; Cytokeratin-71; K71; Keratin 6 irs; Keratin-71; Type II inner root sheath-specific keratin-K6irs1; Type-II keratin Kb34; hK6irs1; hK6irs",
        "protein_names_refseq": "CK-71; K71; cytokeratin-71; hK6irs1; hK6irs; keratin 6 irs; keratin 71, type II; keratin, type II cytoskeletal 71; type II inner root sheath-specific keratin-K6irs1; type-II keratin Kb34",
        "tax_id": 9606,
        "disease": "hypotrichosis 13 (Disease Ontology:DOID:0110710); alopecia (Disease Ontology:DOID:987)",
        "pathway": " (hsa:112802);  (R-HSA-6805567);  (R-HSA-6809371)",
        "pathway_count": 3,
        "publication_count": 62,
        "publication_id_list": "10066784;10196183;10231017;10411887;10588656;10771479;11350120;11380615;11590230;11982755;12648212;12902340;15033990;15337775;15373777;15797384;15803139;16061697;16382671;16639001;16874310;1691188;1694855;1714783;17515931;17521629;17562024;17596512;18843291;19190773;19194479;20068231;20179351;20657595;20667819;20940292;21439340;21654840;21997417;22592156;23481192;23629652;2414304;25208914;25645385;25926655;26390218;28411811;29557506;32373127;32387766;33141586;33981976;34725712;35051231;38665916;7543090;8824274;8999895;9395522;9468612;9565599",
        "class_list": "",
        "function": "A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Flugelzellen) of the human hair follicle.(HK6IRS1), [RefSeq, PubMed]; Demonstration of the heterozygous mutation c.422T>G (p.Phe141Cys) within the helix initiation motif of the inner root sheath-specific keratin K71 (KRT71) gene in affected family members with autosomal dominant woolly hair/hypotrichosis., [RefSeq, PubMed]; Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]., [RefSeq]; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KVC1;Q3SY85;Q96DU2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030280 structural constituent of skin epidermis",
        "go_cellular_component": "GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0045095 keratin filament",
        "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization;GO:0031069 hair follicle morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "Q3SY84-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6PKG0-1",
        "uniprot_id": "LARP1_HUMAN",
        "mass": 123510.0,
        "length": 1096,
        "protein_name": "La-related protein 1",
        "gene_name": "LARP1",
        "organism": "Human",
        "refseq_name": "la-related protein 1 isoform 1",
        "refseq_ac": "NP_056130",
        "gene_names_uniprotkb": "LARP1; KIAA0731; LARP",
        "gene_names_refseq": "LARP1; LARP; Lar1; Lhp1",
        "protein_names_uniprotkb": "La-related protein 1; La ribonucleoprotein domain family member 1",
        "protein_names_refseq": "La ribonucleoprotein domain family member 1; la-related protein 1 isoform 1; la-related protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23367);  (R-HSA-9705671)",
        "pathway_count": 2,
        "publication_count": 193,
        "publication_id_list": "11237011;12019269;12692549;12759408;15060081;15208624;16964243;17081983;17525332;17693683;17924679;18220336;18669648;18691976;19369195;19608861;19690332;20068231;20430826;21406692;21868195;22028470;22223895;22424782;22706990;22941947;23186163;23301498;23481700;23711370;24159927;24275569;24366607;24532714;24714562;24715725;25218447;25418920;25505266;25576301;25645385;25810538;25880248;25892735;25940091;26154972;26206669;26375851;26728094;26735137;26811146;26992070;27543614;27600516;27846572;27862975;27869121;27920218;28063628;28218747;28228285;28379136;28514659;28650797;28657654;28673543;28832583;28834231;28860189;28904123;29242379;29244122;29351928;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30379171;30410026;30429286;30484775;30524438;31373491;31575892;31637018;31844290;31850239;32119511;32157095;32265295;32350084;32353859;32357974;32387766;32428392;32488085;32502341;32589897;32726803;32728199;32897882;32938616;32953130;32979938;32983136;33024073;33060197;33097660;33110251;33141586;33214551;33298915;33349665;33360543;33372174;33372854;33392160;33396605;33440148;33479219;33495715;33514628;33567255;33592498;33691108;33717175;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33912179;33936100;33963333;33968037;33981976;33989516;33990585;34019948;34021074;34054808;34084167;34087483;34110168;34166398;34171305;34239064;34290717;34341353;34357683;34375313;34400613;34439781;34452305;34471099;34502139;34509645;34561969;34597346;34932366;35051231;35102342;35132862;35251023;35254053;35318648;35580925;35643212;36010968;36215666;36241641;36284347;37051252;37070251;37938771;38665916;38691336;39016322;39111634;39182167;39302247;39990658;40307207;40914422",
        "class_list": "",
        "function": "(Microbial infection) Positively regulates the replication of dengue virus (DENV)., [UniProtKB, PubMed]; Enhanced binding of guanylated poly(A) RNA by the LaM domain of LARP1., [RefSeq, PubMed]; LARP1 haploinsufficiency is associated with an autosomal dominant neurodevelopmental disorder., [RefSeq, PubMed]; LARP1, an RNA-binding protein, participates in ovarian cancer cell survival by regulating mitochondrial oxidative phosphorylation in response to the influence of the PI3K/mTOR pathway., [RefSeq, PubMed]; Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA, [RefSeq, PubMed]; RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; [1]H, [13]C, and [15]N resonance assignments of the La Motif of the human La-related protein 1., [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 8,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 8,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 8,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 45,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O94836;Q8N4M2;Q8NB73;Q9UFD7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0045296 cadherin binding;GO:0043024 ribosomal small subunit binding;GO:0008190 eukaryotic initiation factor 4E binding;GO:0008494 translation activator activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex",
        "go_biological_process": "GO:0072752 cellular response to rapamycin;GO:0008283 cell population proliferation;GO:0048255 mRNA stabilization;GO:0010608 post-transcriptional regulation of gene expression;GO:0006413 translational initiation",
        "synthesized_glycan_count": 0,
        "hit_score": 20.3,
        "record_id": "Q6PKG0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IW45-1",
        "uniprot_id": "NNRD_HUMAN",
        "mass": 36576.0,
        "length": 347,
        "protein_name": "ATP-dependent (S)-NAD(P)H-hydrate dehydratase",
        "gene_name": "NAXD",
        "organism": "Human",
        "refseq_name": "ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform b",
        "refseq_ac": "NP_001229810",
        "gene_names_uniprotkb": "NAXD; CARKD",
        "gene_names_refseq": "CARKD; LP3298; NAXD; PEBEL2",
        "protein_names_uniprotkb": "ATP-dependent (S)-NAD(P)H-hydrate dehydratase; 4.2.1.93; ATP-dependent NAD(P)HX dehydratase; Carbohydrate kinase domain-containing protein; NAD(P)HX dehydratase",
        "protein_names_refseq": "ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform b; ATP-dependent (S)-NAD(P)H-hydrate dehydratase; ATP-dependent NAD(P)H-hydrate dehydratase; ATP-dependent NAD(P)HX dehydratase; carbohydrate kinase domain containing; carbohydrate kinase domain-containing protein",
        "tax_id": 9606,
        "disease": "NAD(P)HX dehydratase deficiency (MONDO:MONDO:0034121)",
        "pathway": " (hsa:55739);  (R-HSA-196807)",
        "pathway_count": 2,
        "publication_count": 87,
        "publication_id_list": "10.1101/2023.09.13.557529;10331643;10613898;11237011;11248244;11594753;11788603;11866528;11991719;12359228;12547821;12574164;12790796;13563527;14516279;14966140;15090606;15137942;15381699;15674325;16118205;1637327;16690024;17402747;17604275;17641676;17868694;17914902;18411268;19159218;19531469;20388704;20877624;2129526;21504897;21699903;21933152;21994945;22701565;22822066;23212377;23230272;24611804;24717514;24847004;25418920;25531177;26992070;27862975;28467828;28832583;28834231;28904123;29242379;29557506;29769354;29786170;30410026;30484775;30524438;30576410;30779550;31217245;31844290;31848261;32157095;32350084;32897882;32906142;33087354;33912179;33968037;34171305;35051231;35154160;35251023;35580925;36215666;36241641;37074911;4349867;8182091;8289818;8527488;8575745;8809081;9473669",
        "class_list": "",
        "function": "Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration., [UniProtKB, HAMAP, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Results show that NAXD deficiency can be classified as a metabolite repair disorder in which accumulation of damaged metabolites likely triggers devastating effects in tissues such as the brain and the heart, eventually leading to early childhood death., [RefSeq, PubMed]; Wide tissue distribution of dehydratase and epimerase is consistent with mRNA data for Carkd and Aibp, and their presence in both mitochondria and cytosol is explained by the existence of differently targeted forms of CARKD and AIBP., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DXT4;Q5T9X3;Q9H7W1;Q9NVF5",
        "ec_number_list": "4.2.1.93",
        "go_molecular_function": "GO:0047453 ATP-dependent NAD(P)H-hydrate dehydratase activity;GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0046496 nicotinamide nucleotide metabolic process;GO:0110051 metabolite repair;GO:1901847 nicotinate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.3,
        "record_id": "Q8IW45-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95379-1",
        "uniprot_id": "TFIP8_HUMAN",
        "mass": 23003.0,
        "length": 198,
        "protein_name": "Tumor necrosis factor alpha-induced protein 8",
        "gene_name": "TNFAIP8",
        "organism": "Human",
        "refseq_name": "tumor necrosis factor alpha-induced protein 8 isoform b",
        "refseq_ac": "NP_001071122",
        "gene_names_uniprotkb": "TNFAIP8",
        "gene_names_refseq": "GG2-1; MDC-3.13; NDED; SCC-S2; SCCS2; TNFAIP8",
        "protein_names_uniprotkb": "Tumor necrosis factor alpha-induced protein 8; Head and neck tumor and metastasis-related protein; MDC-3.13; NDED; NF-kappa-B-inducible DED-containing protein; SCC-S2; TNF alpha-induced protein 8; TNF-induced protein GG2-1",
        "protein_names_refseq": "NF-kappa-B-inducible DED-containing protein; TNF-induced protein GG2-1; head and neck tumor and metastasis-related protein; tumor necrosis factor alpha-induced protein 8 isoform b; tumor necrosis factor, alpha induced protein 8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:25816);  (R-HSA-1483255)",
        "pathway_count": 2,
        "publication_count": 49,
        "publication_id_list": "10233894;10644768;11237011;11346652;14724590;19112178;20398053;21924498;25242044;25314070;25418920;25479791;25576301;25892735;26154972;28832583;29242379;29393594;29493099;29508533;29557506;29632711;29769354;30315122;31530632;31844290;31848261;31998317;32387766;32983136;33043033;33392160;33592498;33912179;33968037;34036374;34211107;34433824;34561969;34608264;34932366;35051231;35318648;35580925;36581221;37828075;37938771;37948986;38432512",
        "class_list": "",
        "function": "A chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) complex represses expression of the gene encoding tumor necrosis factor alpha-induced protein 8 (TNFAIP8)., [RefSeq, PubMed]; Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation., [UniProtKB, PubMed, PubMed, PubMed]; Current research status of TNFAIP8 in tumours and other inflammatory conditions (Review). Review article, [RefSeq, PubMed]; Decoupling tumor cell metastasis from growth by cellular pilot protein TNFAIP8., [RefSeq, PubMed]; Kidney tubular epithelial cells control interstitial fibroblast fate by releasing TNFAIP8-encapsulated exosomes. Publication Status: Online-Only, [RefSeq, PubMed]; SCC-S2 is a novel oncogenic factor in cancer cells, [RefSeq, PubMed]; SCC-S2 plays an important role in NSCLC and might be a useful therapeutic target of NSCLC., [RefSeq, PubMed]; Synovial fluid exosome-derived miR-182-5p alleviates osteoarthritis by downregulating TNFAIP8 and promoting autophagy through LC3 signaling., [RefSeq, PubMed]; Tumor Necrosis Factor alpha-Induced Protein 8-Like 1 Binds to Protein Arginine Methyltransferase 1 to Suppress the Methylation of Signal Transducer and Activator of Transcription 3 and Cell Growth in Oral Squamous Cell Carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KMH1;B3KMI2;B7Z713;Q9P1Q1;Q9UER5;Q9UP47",
        "ec_number_list": "",
        "go_molecular_function": "GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:1902531 regulation of intracellular signal transduction;GO:0042981 regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "O95379-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P23763-1",
        "uniprot_id": "VAMP1_HUMAN",
        "mass": 12902.0,
        "length": 118,
        "protein_name": "Vesicle-associated membrane protein 1",
        "gene_name": "VAMP1",
        "organism": "Human",
        "refseq_name": "vesicle-associated membrane protein 1 isoform 1",
        "refseq_ac": "NP_055046",
        "gene_names_uniprotkb": "VAMP1; SYB1",
        "gene_names_refseq": "CMS25; SAX1; SPAX1; SYB1; VAMP-1; VAMP1",
        "protein_names_uniprotkb": "Vesicle-associated membrane protein 1; Synaptobrevin-1; VAMP-1",
        "protein_names_refseq": "spastic ataxia 1 (autosomal dominant); vesicle-associated membrane protein 1 (synaptobrevin 1); vesicle-associated membrane protein 1 isoform 1",
        "tax_id": 9606,
        "disease": "spastic ataxia 1 (Disease Ontology:DOID:0050772); congenital myasthenic syndrome (Disease Ontology:DOID:3635); myasthenic syndrome, congenital, 25, presynaptic (MONDO:MONDO:0032675)",
        "pathway": " (hsa:6843);  (R-HSA-5250955);  (R-HSA-5250981);  (R-HSA-5250989)",
        "pathway_count": 4,
        "publication_count": 48,
        "publication_id_list": "11237011;12459720;15217342;16112699;16519520;19476346;19650874;1976629;20166139;20233039;21483489;21632541;22289120;22454523;22958904;23328677;23481700;23647335;25548167;25576301;27452731;28168212;28228285;28253535;28600779;28649982;28832583;29242379;29508533;29540745;29557506;29774024;31154438;31844290;32350084;32387766;33631708;34454100;36215666;36241641;38355957;7527117;7910017;8051110;8175689;8226912;8402889;9658161",
        "class_list": "",
        "function": "Expanding the genetic and phenotypic spectrum of congenital myasthenic syndrome: new homozygous VAMP1 splicing variants in 2 novel individuals., [RefSeq, PubMed]; Involved in the targeting and/or fusion of transport vesicles to their target membrane., [UniProtKB]; Prefrontal cortex VAMP1 gene network moderates the effect of the early environment on cognitive flexibility in children., [RefSeq, PubMed]; Recessive VAMP1 mutations associated with severe congenital myasthenic syndromes - A recognizable clinical phenotype., [RefSeq, PubMed]; Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]., [RefSeq]; This report identifies vesicle-associated membrane protein 1 (VAMP1), which encodes a critical protein for synaptic exocytosis, as the responsible gene fora dominantly inherited spastic ataxia, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MVP3;D3DUR3;O75468;Q15857;Q6FG94;Q8IVC9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity",
        "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0035579 specific granule membrane;GO:0070821 tertiary granule membrane",
        "go_biological_process": "GO:0007269 neurotransmitter secretion;GO:0035493 SNARE complex assembly;GO:0006906 vesicle fusion;GO:0016192 vesicle-mediated transport",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "P23763-1",
        "record_type": "protein"
    }
]