{
    "disease_id": "DOID:0081445",
    "recommended_name": {
        "id": "DOID:0081445",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0081445",
        "name": "sickle cell disease",
        "description": "A blood protein disease that is characterized by chronic hemolytic anemia and intermittent vaso-occlusive events that result in tissue ischemia leading to acute and chronic pain as well as organ damage that can affect any organ system, resulting from the replacement of one of the beta-globin subunits in hemoglobin with atypical hemoglobin molecules called hemoglobin S which can distort red blood cells into a sickle or crescent shape. Sickle cell disease subtypes should include a detailed genotypic description for the hemoglobin molecules (e.g., Hb S/S, Hb S/C, Hb S/0-thalassemia)."
    },
    "synonyms": [
        {
            "id": "MONDO:0011382",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011382",
            "name": "sickle cell disease",
            "description": "Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur."
        },
        {
            "id": "MONDO:0011382",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011382",
            "name": "Haemoglobin S disease without crisis",
            "description": ""
        },
        {
            "id": "MONDO:0011382",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011382",
            "name": "Hb-S/Hb-C disease",
            "description": ""
        },
        {
            "id": "MONDO:0011382",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011382",
            "name": "Sickle Cell Disease",
            "description": ""
        },
        {
            "id": "MONDO:0011382",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011382",
            "name": "sickle cell anemia",
            "description": ""
        },
        {
            "id": "MONDO:0011382",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011382",
            "name": "sickle cell disease",
            "description": ""
        },
        {
            "id": "MONDO:0011382",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011382",
            "name": "sickle-cell/Hb-C disease without crisis",
            "description": ""
        },
        {
            "id": "MONDO:0011382",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011382",
            "name": "sickling disorder due to Haemoglobin S",
            "description": ""
        },
        {
            "id": "MONDO:0011382",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011382",
            "name": "sickling disorder due to Hemoglobin S",
            "description": ""
        },
        {
            "id": "MONDO:0011382",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011382",
            "name": "HPA 1 recognition polymorphism, beta-globin-related",
            "description": ""
        },
        {
            "id": "MONDO:0011382",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011382",
            "name": "HPA1",
            "description": ""
        },
        {
            "id": "MONDO:0011382",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011382",
            "name": "Haemoglobin S disease",
            "description": ""
        },
        {
            "id": "MONDO:0011382",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011382",
            "name": "HbS disease",
            "description": ""
        },
        {
            "id": "MONDO:0011382",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011382",
            "name": "Hemoglobin S disease",
            "description": ""
        },
        {
            "id": "MIM:603903",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/603903",
            "name": "Sickle cell disease",
            "description": "Sickle cell disease"
        }
    ],
    "children": [
        {
            "id": "DOID:10923",
            "label": "sickle cell anemia",
            "link_status": true,
            "children": []
        }
    ],
    "id_list": [
        "DOID:0081445",
        "DOID:10923"
    ],
    "unlinked_id_list": []
}