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"https://www.uniprot.org/uniprotkb/Q1LWJ7" } ], "pmid": "" }, { "name": "peptide catabolic process", "id": "GO:0043171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043171", "evidence": [ { "database": "UniProtKB", "id": "Q1LWJ7", "url": "https://www.uniprot.org/uniprotkb/Q1LWJ7" } ], "pmid": "" } ], "molecular_function": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q1LWJ7", "url": "https://www.uniprot.org/uniprotkb/Q1LWJ7" } ], "pmid": "" }, { "name": "metalloaminopeptidase activity", "id": "GO:0070006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070006", "evidence": [ { "database": "UniProtKB", "id": "Q1LWJ7", "url": "https://www.uniprot.org/uniprotkb/Q1LWJ7" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.zebrafish.3" }, { "uniprot_canonical_ac": "Q1LWL2-1", "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "Q1LWL2", "url": "https://www.uniprot.org/uniprotkb/Q1LWL2" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "length": 208, "chemical_mass": 23386.0, "gene_names": "dusp22a;dusp22a;dusp22;si:dkey-190g1.1;wu:fa11e09;zgc:92816", "protein_name": "Dual specificity protein phosphatase 22-A", "disease": [], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q1LWL2", "url": "https://www.uniprot.org/uniprotkb/Q1LWL2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q1LWL2", "url": "https://www.uniprot.org/uniprotkb/Q1LWL2" } ], "pmid": "" } ], "biological_process": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q1LWL2", "url": "https://www.uniprot.org/uniprotkb/Q1LWL2" } ], "pmid": "" }, { "name": "regulation of cell adhesion", "id": "GO:0030155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030155", "evidence": [ { "database": "UniProtKB", "id": "Q1LWL2", "url": "https://www.uniprot.org/uniprotkb/Q1LWL2" } ], "pmid": "" }, { "name": "cellular response to growth factor stimulus", "id": "GO:0071363", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071363", "evidence": [ { "database": "UniProtKB", "id": "Q1LWL2", "url": "https://www.uniprot.org/uniprotkb/Q1LWL2" } ], "pmid": "" }, { "name": "negative regulation of T cell receptor signaling pathway", "id": "GO:0050860", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050860", "evidence": [ { "database": "UniProtKB", "id": "Q1LWL2", "url": "https://www.uniprot.org/uniprotkb/Q1LWL2" } ], "pmid": "" } ], "molecular_function": [ { "name": "protein serine/threonine phosphatase activity", "id": "GO:0004722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004722", "evidence": [ { "database": "UniProtKB", "id": "Q1LWL2", "url": "https://www.uniprot.org/uniprotkb/Q1LWL2" } ], "pmid": "" }, { "name": "protein tyrosine kinase binding", "id": "GO:1990782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990782", "evidence": [ { "database": "UniProtKB", "id": "Q1LWL2", "url": "https://www.uniprot.org/uniprotkb/Q1LWL2" } ], "pmid": "" }, { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "Q1LWL2", "url": "https://www.uniprot.org/uniprotkb/Q1LWL2" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.zebrafish.3" }, { "uniprot_canonical_ac": "Q1LWR1-1", "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "Q1LWR1", "url": "https://www.uniprot.org/uniprotkb/Q1LWR1" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "length": 118, "chemical_mass": 13338.0, "gene_names": "polr1h;polr1h;zgc:110825;znrd1", "protein_name": "DNA-directed RNA polymerase subunit", "disease": [], "cellular_component": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q1LWR1", "url": "https://www.uniprot.org/uniprotkb/Q1LWR1" } ], "pmid": "" }, { "name": "RNA polymerase I complex", "id": "GO:0005736", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005736", "evidence": [ { "database": "UniProtKB", "id": "Q1LWR1", "url": "https://www.uniprot.org/uniprotkb/Q1LWR1" } ], "pmid": "" } ], "molecular_function": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q1LWR1", "url": "https://www.uniprot.org/uniprotkb/Q1LWR1" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "Q1LWR1", "url": "https://www.uniprot.org/uniprotkb/Q1LWR1" } ], "pmid": "" }, { "name": "DNA-directed RNA polymerase activity", "id": "GO:0003899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003899", "evidence": [ { "database": "UniProtKB", "id": "Q1LWR1", "url": "https://www.uniprot.org/uniprotkb/Q1LWR1" } ], "pmid": "" } ], "biological_process": [ { "name": "termination of RNA polymerase I transcription", "id": "GO:0006363", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006363", "evidence": [ { "database": "UniProtKB", "id": "Q1LWR1", "url": "https://www.uniprot.org/uniprotkb/Q1LWR1" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.zebrafish.3" }, { "uniprot_canonical_ac": "Q1LWV7-1", "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "Q1LWV7", "url": "https://www.uniprot.org/uniprotkb/Q1LWV7" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "length": 450, "chemical_mass": 49949.0, "gene_names": "meak7;KIAA1609;fj85b03;meak7;plcg2;sb:eu1064;si:ch211-260p9.2;si:ch211-260p9.6;tldc1;wu:fj85b03;zgc:152893;zgc:153621", "protein_name": "MTOR-associated protein MEAK7", "disease": [ { "disease_id": "DOID:0070615", "name": "autoinflammation, antibody deficiency, and immune dysregulation syndrome", "description": "An autoimmune disease characterized by recurrent blistering skin lesions with a dense inflammatory infiltrate and variable involvement of other tissues, including joints, the eye, and the gastrointestinal tract that has_material_basis in heterozygous mutation in the PLCG2 gene on chromosome 16q23.", "url": "https://disease-ontology.org/term/DOID:0070615", "evidence": [ { "id": "0070615", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070615" } ], "weight": 0.0 }, { "disease_id": "DOID:0090064", "name": "familial cold autoinflammatory syndrome 3", "description": "A familial cold autoinflammatory syndrome characterized by autosomal dominant inheritance of development of cutaneous urticaria, erythema and pruritus in response to cold exposure with. FCAS3 has_material_basis_in heterozygous deletion within the PLCG2 gene on chromosome 16q.", "url": "https://disease-ontology.org/term/DOID:0090064", "evidence": [ { "id": "0090064", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0090064" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q1LWV7", "url": "https://www.uniprot.org/uniprotkb/Q1LWV7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q1LWV7", "url": "https://www.uniprot.org/uniprotkb/Q1LWV7" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q1LWV7", "url": "https://www.uniprot.org/uniprotkb/Q1LWV7" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "Q1LWV7", "url": "https://www.uniprot.org/uniprotkb/Q1LWV7" } ], "pmid": "" }, { "name": "membrane raft", "id": "GO:0045121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121", "evidence": [ { "database": "UniProtKB", "id": "Q1LWV7", "url": "https://www.uniprot.org/uniprotkb/Q1LWV7" } ], "pmid": "" } ], "biological_process": [ { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "Q1LWV7", "url": "https://www.uniprot.org/uniprotkb/Q1LWV7" } ], "pmid": "" }, { "name": "regulation of cell population proliferation", "id": "GO:0042127", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042127", "evidence": [ { "database": "UniProtKB", "id": "Q1LWV7", "url": "https://www.uniprot.org/uniprotkb/Q1LWV7" } ], "pmid": "" }, { "name": "response to nutrient levels", "id": "GO:0031667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031667", "evidence": [ { "database": "UniProtKB", "id": "Q1LWV7", "url": "https://www.uniprot.org/uniprotkb/Q1LWV7" } ], "pmid": "" }, { "name": "response to insulin", "id": "GO:0032868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032868", "evidence": [ { "database": "UniProtKB", "id": "Q1LWV7", "url": "https://www.uniprot.org/uniprotkb/Q1LWV7" } ], "pmid": "" }, { "name": "regulation of cell migration", "id": "GO:0030334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030334", "evidence": [ { "database": "UniProtKB", "id": "Q1LWV7", "url": "https://www.uniprot.org/uniprotkb/Q1LWV7" } ], "pmid": "" }, { "name": "TOR signaling", "id": "GO:0031929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031929", "evidence": [ { "database": "UniProtKB", "id": "Q1LWV7", "url": "https://www.uniprot.org/uniprotkb/Q1LWV7" } ], "pmid": "" }, { "name": "response to amino acid", "id": "GO:0043200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043200", "evidence": [ { "database": "UniProtKB", "id": "Q1LWV7", "url": "https://www.uniprot.org/uniprotkb/Q1LWV7" } ], "pmid": "" }, { "name": "positive regulation of protein localization to lysosome", "id": "GO:0150032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150032", "evidence": [ { "database": "UniProtKB", "id": "Q1LWV7", "url": "https://www.uniprot.org/uniprotkb/Q1LWV7" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "Q1LWV7", "url": "https://www.uniprot.org/uniprotkb/Q1LWV7" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "Q1LWV7", "url": "https://www.uniprot.org/uniprotkb/Q1LWV7" } ], "pmid": "" }, { "name": "phospholipid catabolic process", "id": "GO:0009395", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009395", "evidence": [ { "database": "UniProtKB", "id": "Q1LWV7", "url": "https://www.uniprot.org/uniprotkb/Q1LWV7" } ], "pmid": "" }, { "name": "positive regulation of intracellular signal transduction", "id": "GO:1902533", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902533", "evidence": [ { "database": "UniProtKB", "id": "Q1LWV7", "url": "https://www.uniprot.org/uniprotkb/Q1LWV7" } ], "pmid": "" } ], "molecular_function": [ { "name": "phosphatidylinositol-4,5-bisphosphate phospholipase C activity", "id": "GO:0004435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004435", "evidence": [ { "database": "UniProtKB", "id": "Q1LWV7", "url": "https://www.uniprot.org/uniprotkb/Q1LWV7" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.zebrafish.3" }, { "uniprot_canonical_ac": "Q1LWX3-1", "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "Q1LWX3", "url": "https://www.uniprot.org/uniprotkb/Q1LWX3" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "length": 202, "chemical_mass": 23546.0, "gene_names": "ntaq1;ntaq1;si:rp71-45k5.3;wdyhv1", "protein_name": "Protein N-terminal glutamine amidohydrolase", "disease": [], "biological_process": [ { "name": "protein modification process", "id": "GO:0036211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036211", "evidence": [ { "database": "UniProtKB", "id": "Q1LWX3", "url": "https://www.uniprot.org/uniprotkb/Q1LWX3" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q1LWX3", "url": "https://www.uniprot.org/uniprotkb/Q1LWX3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q1LWX3", "url": "https://www.uniprot.org/uniprotkb/Q1LWX3" } ], "pmid": "" } ], "molecular_function": [ { "name": "protein-N-terminal asparagine amidohydrolase activity", "id": "GO:0008418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008418", "evidence": [ { "database": "UniProtKB", "id": "Q1LWX3", "url": "https://www.uniprot.org/uniprotkb/Q1LWX3" } ], "pmid": "" }, { "name": "protein-N-terminal glutamine amidohydrolase activity", "id": "GO:0070773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070773", "evidence": [ { "database": "UniProtKB", "id": "Q1LWX3", "url": "https://www.uniprot.org/uniprotkb/Q1LWX3" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.zebrafish.3" }, { "uniprot_canonical_ac": "Q1LX29-1", "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "Q1LX29", "url": "https://www.uniprot.org/uniprotkb/Q1LX29" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "length": 814, "chemical_mass": 92807.0, "gene_names": "ccdc79;si:dkey-238c7.7;si:dkey-30c15.5;terb1", "protein_name": "Telomere repeats-binding bouquet formation protein 1", "disease": [ { "disease_id": "DOID:0112355", "name": "spermatogenic failure 60", "description": "A spermatogenic failure that is characterized by male infertility due to nonobstructive azoospermia that has_material_basis_in homozygous or compound heterozygous mutation in the TERB1 gene on chromosome 16q22.1.", "url": "https://disease-ontology.org/term/DOID:0112355", "evidence": [ { "id": "0112355", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0112355" } ], "weight": 0.0 } ], "biological_process": [ { "name": "meiotic attachment of telomere to nuclear envelope", "id": "GO:0070197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070197", "evidence": [ { "database": "UniProtKB", "id": "Q1LX29", "url": "https://www.uniprot.org/uniprotkb/Q1LX29" } ], "pmid": "" }, { "name": "homologous chromosome pairing at meiosis", "id": "GO:0007129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007129", "evidence": [ { "database": "UniProtKB", "id": "Q1LX29", "url": "https://www.uniprot.org/uniprotkb/Q1LX29" } ], "pmid": "" }, { "name": "meiotic telomere clustering", "id": "GO:0045141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045141", "evidence": [ { "database": "UniProtKB", "id": "Q1LX29", "url": "https://www.uniprot.org/uniprotkb/Q1LX29" } ], "pmid": "" } ], "cellular_component": [ { "name": "nuclear inner membrane", "id": "GO:0005637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005637", "evidence": [ { "database": "UniProtKB", "id": "Q1LX29", "url": "https://www.uniprot.org/uniprotkb/Q1LX29" } ], "pmid": "" }, { "name": "chromosome, telomeric region", "id": "GO:0000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "evidence": [ { "database": "UniProtKB", "id": "Q1LX29", "url": "https://www.uniprot.org/uniprotkb/Q1LX29" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.zebrafish.3" }, { "uniprot_canonical_ac": "Q1LX46-1", "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "Q1LX46", "url": "https://www.uniprot.org/uniprotkb/Q1LX46" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "length": 1012, "chemical_mass": 111233.0, "gene_names": "slc12a3;si:ch211-122c9.4;slc12a3;wu:fj83c03", "protein_name": "Solute carrier family 12 member 3", "disease": [ { "disease_id": "DOID:0050450", "name": "Gitelman syndrome", "description": "A renal tubular transport disease that is has_material_basis_in mutations in genes that produce proteins involved in the kidneys' reabsorption of salt (sodium chloride or NaCl) from urine back into the bloodstream, thus impairing the kidneys' ability to reabsorb salt, leading to the 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The five cardiometabolic risk factors are: (1) higher than normal body mass index or waist circumference; (2) higher than normal serum glucose or glycated hemoglobin level, or type 2 diabetes; (3) higher than normal blood pressure or hypertensive treatment; (4) higher than normal plasma triglycerides or lipid lowering treatment; and (5) lower than normal plasma high-density lipoprotein cholesterol.", "url": "https://disease-ontology.org/term/DOID:0070508", "evidence": [ { "id": "0070508", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070508" } ], "weight": 0.0 }, { "disease_id": "DOID:0070658", "name": "alcohol-associated liver disease", "description": "A liver disease resulting from excessive alcohol intake.", "url": "https://disease-ontology.org/term/DOID:0070658", "evidence": [ { "id": "0070658", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070658" } ], "weight": 0.0 }, { "disease_id": "DOID:1682", "name": "congenital heart disease", "description": "A physical disorder that is characterized by problems with the heart's structure that are present at birth.", "url": "https://disease-ontology.org/term/DOID:1682", "evidence": [ { "id": "1682", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1682" } ], "weight": 0.0 }, { "disease_id": "DOID:3526", "name": "cerebral infarction", "description": "A cerebrovascular disease that is characterized by an area of necrotic tissue in the brain resulting from a blockage or narrowing in the arteries supplying blood and oxygen to the brain.", "url": "https://disease-ontology.org/term/DOID:3526", "evidence": [ { "id": "3526", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3526" } ], "weight": 0.0 }, { "disease_id": "DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.", "url": "https://disease-ontology.org/term/DOID:684", "evidence": [ { "id": "684", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:684" } ], "weight": 0.0 }, { "disease_id": "DOID:9477", "name": "pulmonary embolism", "description": "An artery disease characterized by a blockage of the main artery of the lung or one of its branches by a substance that has travelled from elsewhere in the body, e.g. a blood clot.", "url": "https://disease-ontology.org/term/DOID:9477", "evidence": [ { "id": "9477", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9477" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q32LQ4", "url": "https://www.uniprot.org/uniprotkb/Q32LQ4" } ], "pmid": "" } ], "molecular_function": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q32LQ4", "url": "https://www.uniprot.org/uniprotkb/Q32LQ4" } ], "pmid": "" }, { "name": "betaine-homocysteine S-methyltransferase activity", "id": "GO:0047150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047150", "evidence": [ { "database": "UniProtKB", "id": "Q32LQ4", "url": "https://www.uniprot.org/uniprotkb/Q32LQ4" } ], "pmid": "" } ], "biological_process": [ { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "Q32LQ4", "url": "https://www.uniprot.org/uniprotkb/Q32LQ4" } ], "pmid": "" }, { "name": "digestive system development", "id": "GO:0055123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055123", "evidence": [ { "database": "UniProtKB", "id": "Q32LQ4", "url": "https://www.uniprot.org/uniprotkb/Q32LQ4" } ], "pmid": "" }, { "name": "type B pancreatic cell development", "id": "GO:0003323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003323", "evidence": [ { "database": "UniProtKB", "id": "Q32LQ4", "url": "https://www.uniprot.org/uniprotkb/Q32LQ4" } ], "pmid": "" }, { "name": "amino-acid betaine catabolic process", "id": "GO:0006579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006579", "evidence": [ { "database": "UniProtKB", "id": "Q32LQ4", "url": "https://www.uniprot.org/uniprotkb/Q32LQ4" } ], "pmid": "" }, { "name": "L-methionine salvage", "id": "GO:0071267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071267", "evidence": [ { "database": "UniProtKB", "id": "Q32LQ4", "url": "https://www.uniprot.org/uniprotkb/Q32LQ4" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.zebrafish.3" }, { "uniprot_canonical_ac": "Q32LU7-1", "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "Q32LU7", "url": "https://www.uniprot.org/uniprotkb/Q32LU7" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "length": 667, "chemical_mass": 76005.0, "gene_names": "ptcd3;zgc:123014", "protein_name": "Small ribosomal subunit protein mS39", "disease": [ { "disease_id": "DOID:0112137", "name": "combined oxidative phosphorylation deficiency 51", "description": "A combined oxidative phosphorylation deficiency that has_material_basis_in homozygous or compound heterozygous mutation in the PTCD3 gene on chromosome 2p11.2.", "url": "https://disease-ontology.org/term/DOID:0112137", "evidence": [ { "id": "0112137", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0112137" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q32LU7", "url": "https://www.uniprot.org/uniprotkb/Q32LU7" } ], "pmid": "" }, { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "Q32LU7", "url": "https://www.uniprot.org/uniprotkb/Q32LU7" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q32LU7", "url": "https://www.uniprot.org/uniprotkb/Q32LU7" } ], "pmid": "" } ], "biological_process": [ { "name": "regulation of translation", "id": "GO:0006417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006417", "evidence": [ { "database": "UniProtKB", "id": "Q32LU7", "url": "https://www.uniprot.org/uniprotkb/Q32LU7" } ], "pmid": "" }, { "name": "mitochondrial translation", "id": "GO:0032543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032543", "evidence": [ { "database": "UniProtKB", "id": "Q32LU7", "url": "https://www.uniprot.org/uniprotkb/Q32LU7" } ], "pmid": "" } ], "molecular_function": [ { "name": "ribosomal small subunit binding", "id": "GO:0043024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043024", "evidence": [ { "database": "UniProtKB", "id": "Q32LU7", "url": "https://www.uniprot.org/uniprotkb/Q32LU7" } ], "pmid": "" }, { "name": "rRNA binding", "id": "GO:0019843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019843", "evidence": [ { "database": "UniProtKB", "id": "Q32LU7", "url": "https://www.uniprot.org/uniprotkb/Q32LU7" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.zebrafish.3" }, { "uniprot_canonical_ac": "Q32PN7-1", "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "Q32PN7", "url": "https://www.uniprot.org/uniprotkb/Q32PN7" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "length": 756, "chemical_mass": 86384.0, "gene_names": "dzip1l;dzip1l;zgc:123017", "protein_name": "Cilium assembly protein DZIP1L", "disease": [ { "disease_id": "DOID:0080273", "name": "polycystic kidney disease 5", "description": "A autosomal recessive polycystic kidney disease that has_material_basis_in autosomal dominant inheritance of homozygous mutation in the DZIP1L gene on chromosome 3q22.", "url": "https://disease-ontology.org/term/DOID:0080273", "evidence": [ { "id": "0080273", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080273" } ], "weight": 0.0 }, { "disease_id": "DOID:0110861", "name": "autosomal recessive polycystic kidney disease", "description": "A polycystic kidney disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium, inherited in an autosomal recessive fashion.", "url": "https://disease-ontology.org/term/DOID:0110861", "evidence": [ { "id": "0110861", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110861" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32PN7", "url": "https://www.uniprot.org/uniprotkb/Q32PN7" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "Q32PN7", "url": "https://www.uniprot.org/uniprotkb/Q32PN7" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "Q32PN7", "url": "https://www.uniprot.org/uniprotkb/Q32PN7" } ], "pmid": "" } ], "molecular_function": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q32PN7", "url": "https://www.uniprot.org/uniprotkb/Q32PN7" } ], "pmid": "" } ], "biological_process": [ { "name": "regulation of protein localization", "id": "GO:0032880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032880", "evidence": [ { "database": "UniProtKB", "id": "Q32PN7", "url": "https://www.uniprot.org/uniprotkb/Q32PN7" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "Q32PN7", "url": "https://www.uniprot.org/uniprotkb/Q32PN7" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "Q32PN7-1", "start_pos": "588", "end_pos": "588", "site_lbl": "Thr588", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 588, "start_aa": "Thr", "end_pos": 588, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr588", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ] } ], "record_id": "batch.zebrafish.3" }, { "uniprot_canonical_ac": "Q32PR0-1", "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "Q32PR0", "url": "https://www.uniprot.org/uniprotkb/Q32PR0" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "length": 270, "chemical_mass": 28766.0, "gene_names": "tmem55ba;fe11b12;pip4p1a;tmem55ba;wu:fe11b12;zgc:123304", "protein_name": "Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-A", "disease": [], "molecular_function": [ { "name": "phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity", "id": "GO:0034597", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034597", "evidence": [ { "database": "UniProtKB", "id": "Q32PR0", "url": "https://www.uniprot.org/uniprotkb/Q32PR0" } ], "pmid": "" } ], "cellular_component": [ { "name": "plasma 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"name": "CDP-diacylglycerol biosynthetic process", "id": "GO:0016024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016024", "evidence": [ { "database": "UniProtKB", "id": "Q3B7H2", "url": "https://www.uniprot.org/uniprotkb/Q3B7H2" } ], "pmid": "" }, { "name": "cardiolipin biosynthetic process", "id": "GO:0032049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032049", "evidence": [ { "database": "UniProtKB", "id": "Q3B7H2", "url": "https://www.uniprot.org/uniprotkb/Q3B7H2" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.zebrafish.3" }, { "uniprot_canonical_ac": "Q499A3-1", "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "Q499A3", "url": "https://www.uniprot.org/uniprotkb/Q499A3" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "length": 566, "chemical_mass": 62676.0, "gene_names": "dnaaf2;dnaaf2;ktu;zgc:110294", 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"UniProtKB", "id": "Q499B3", "url": "https://www.uniprot.org/uniprotkb/Q499B3" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "Q499B3", "url": "https://www.uniprot.org/uniprotkb/Q499B3" } ], "pmid": "" }, { "name": "histone acetyltransferase complex", "id": "GO:0000123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000123", "evidence": [ { "database": "UniProtKB", "id": "Q499B3", "url": "https://www.uniprot.org/uniprotkb/Q499B3" } ], "pmid": "" }, { "name": "NSL complex", "id": "GO:0044545", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044545", "evidence": [ { "database": "UniProtKB", "id": "Q499B3", "url": "https://www.uniprot.org/uniprotkb/Q499B3" } ], "pmid": "" } ], "biological_process": [ { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "Q499B3", "url": "https://www.uniprot.org/uniprotkb/Q499B3" } ], "pmid": "" }, { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "Q499B3", "url": "https://www.uniprot.org/uniprotkb/Q499B3" } ], "pmid": "" }, { "name": "regulation of mitochondrial transcription", "id": "GO:1903108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903108", "evidence": [ { "database": "UniProtKB", "id": "Q499B3", "url": "https://www.uniprot.org/uniprotkb/Q499B3" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "Q499B3-1", "start_pos": "620", "end_pos": "620", "site_lbl": "Thr620", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 620, "start_aa": "Thr", "end_pos": 620, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr620", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ] }, { "uniprot_canonical_ac": "Q499B3-1", "start_pos": "86", "end_pos": "86", "site_lbl": "Thr86", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 86, "start_aa": "Thr", "end_pos": 86, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr86", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ] } ], "record_id": "batch.zebrafish.3" }, { "uniprot_canonical_ac": "Q4G6A6-1", "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "Q4G6A6", "url": "https://www.uniprot.org/uniprotkb/Q4G6A6" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "length": 104, "chemical_mass": 11288.0, "gene_names": "bglap;bglap;si:ch1073-504d15.2", "protein_name": "Bone Gla protein", "disease": [ { "disease_id": "DOID:0080652", "name": "calcium oxalate nephrolithiasis", "description": "A nephrolithiasis that is characterized by characterized by stones composed of calcium oxalate and that has_material_basis_in compound heterozygous mutation in the SLC26A1 gene on chromosome 4p16.", "url": "https://disease-ontology.org/term/DOID:0080652", "evidence": [ { "id": "0080652", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080652" } ], "weight": 0.0 }, { "disease_id": "DOID:0111253", "name": "neurofibromatosis 1", "description": "A neurofibromatosis 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Bone abnormalities include a distinctive osseous lesion such as sphenoid dysplasia, anterolateral bowing of the tibia, or pseudarthrosis of a long bone.", "url": "https://disease-ontology.org/term/DOID:0111253", "evidence": [ { "id": "0111253", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111253" } ], "weight": 0.0 }, { "disease_id": "DOID:0111535", "name": "progressive osseous heteroplasia", "description": "A syndrome characterized by infantile onset of dermal ossification followed by progressive bone formation in skeletal muscle and deep fascia that has_material_basis_in heterozygous loss of function mutation in the Gs-alpha isoform of the GNAS gene on chromosome 20q13.32.", "url": "https://disease-ontology.org/term/DOID:0111535", "evidence": [ { "id": "0111535", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111535" } ], "weight": 0.0 }, { "disease_id": "DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate.", "url": "https://disease-ontology.org/term/DOID:10283", "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ], "weight": 0.0 }, { "disease_id": "DOID:11249", "name": "vitamin K deficiency bleeding", "description": "A nutritional deficiency disease that is characterized by easy bleeding due to an inability to form blood clots caused by vitamin K deficiency, occurs most commonly in newborns, and has_material_basis_in deficiency of vitamin K secondary to liver prematurity, lack of vitamin K in a breastmilk diet, largely sterile gut, malabsorption, diarrhea, chronic illness, menorrhagia, chronic kidney disease, and some medications.", "url": "https://disease-ontology.org/term/DOID:11249", "evidence": [ { "id": "11249", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11249" } ], "weight": 0.0 }, { "disease_id": "DOID:11476", "name": "osteoporosis", "description": "A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength.", "url": "https://disease-ontology.org/term/DOID:11476", "evidence": [ { "id": "11476", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11476" } ], "weight": 0.0 }, { "disease_id": "DOID:1184", "name": "nephrotic syndrome", "description": "A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability.", "url": "https://disease-ontology.org/term/DOID:1184", "evidence": [ { "id": "1184", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1184" } ], "weight": 0.0 }, { "disease_id": "DOID:14330", "name": "Parkinson's disease", "description": "A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor 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"description": "An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.", "url": "https://disease-ontology.org/term/DOID:7148", "evidence": [ { "id": "7148", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:7148" } ], "weight": 0.0 }, { "disease_id": "DOID:783", "name": "end stage renal disease", "description": "A chronic kidney disease is characterized by non-functioning kidneys, as the final stage in chronic kidney disease.", "url": "https://disease-ontology.org/term/DOID:783", "evidence": [ { "id": "783", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:783" } ], "weight": 0.0 }, { "disease_id": "DOID:8398", "name": "osteoarthritis", "description": "An arthritis that has_material_basis_in worn out cartilage located_in joint.", "url": "https://disease-ontology.org/term/DOID:8398", "evidence": [ { "id": "8398", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8398" } ], 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"name": "response to steroid hormone", "id": "GO:0048545", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048545", "evidence": [ { "database": "UniProtKB", "id": "Q503Q1", "url": "https://www.uniprot.org/uniprotkb/Q503Q1" } ], "pmid": "" }, { "name": "mitochondrial protein catabolic process", "id": "GO:0035694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035694", "evidence": [ { "database": "UniProtKB", "id": "Q503Q1", "url": "https://www.uniprot.org/uniprotkb/Q503Q1" } ], "pmid": "" }, { "name": "mitophagy by internal vacuole formation", "id": "GO:0035695", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035695", "evidence": [ { "database": "UniProtKB", "id": "Q503Q1", "url": "https://www.uniprot.org/uniprotkb/Q503Q1" } ], "pmid": "" } ], "molecular_function": [ { "name": "cardiolipin binding", "id": "GO:1901612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901612", "evidence": [ { "database": "UniProtKB", "id": "Q503Q1", "url": "https://www.uniprot.org/uniprotkb/Q503Q1" } ], 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cation-selective channel activity", "id": "GO:0022848", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022848", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PIT7", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PIT7" } ], "pmid": "" }, { "name": "serotonin-gated monoatomic cation channel activity", "id": "GO:0022850", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022850", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PIT7", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PIT7" } ], "pmid": "" }, { "name": "transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "id": "GO:1904315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904315", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PIT7", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PIT7" } ], "pmid": "" }, { "name": "excitatory extracellular ligand-gated monoatomic ion channel activity", "id": "GO:0005231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005231", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PIT7", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PIT7" } ], "pmid": "" } ], "biological_process": [ { "name": "regulation of membrane potential", "id": "GO:0042391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042391", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PIT7", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PIT7" } ], "pmid": "" }, { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PIT7", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PIT7" } ], "pmid": "" }, { "name": "monoatomic ion transmembrane transport", "id": "GO:0034220", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034220", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PIT7", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PIT7" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.zebrafish.3" }, { "uniprot_canonical_ac": "A0A8M9PIY6-1", "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PIY6", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PIY6" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "length": 900, "chemical_mass": 97649.0, "gene_names": "si:dkey-175m17.7;si:dkey-175m17.7", "protein_name": "protein-tyrosine-phosphatase", "disease": [ { "disease_id": "DOID:305", "name": "carcinoma", "description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.", "url": "https://disease-ontology.org/term/DOID:305", "evidence": [ { "id": "305", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:305" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PIY6", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PIY6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PIY6", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PIY6" } ], "pmid": "" } ], "biological_process": [ { "name": "negative regulation of JNK cascade", "id": "GO:0046329", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046329", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PIY6", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PIY6" } ], "pmid": "" } ], "molecular_function": [ { "name": "MAP kinase tyrosine/serine/threonine phosphatase activity", "id": "GO:0017017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017017", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PIY6", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PIY6" } ], "pmid": "" }, { "name": "protein tyrosine/threonine phosphatase activity", "id": "GO:0008330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008330", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PIY6", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PIY6" } ], "pmid": "" }, { "name": "MAP kinase tyrosine phosphatase activity", "id": "GO:0033550", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033550", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PIY6", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PIY6" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.zebrafish.3" }, { "uniprot_canonical_ac": "A0A8M9PJ26-1", "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PJ26", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PJ26" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "length": 94, "chemical_mass": 10549.0, "gene_names": "ccl20a.4;ccl20a.4", "protein_name": "C-C motif chemokine", "disease": [ { "disease_id": "DOID:0050486", "name": "exanthem", "description": "A skin disease that is characterized by a rash that results from a variety of causes including bacteria, viruses, toxins, drugs and autoimmune disorders.", "url": "https://disease-ontology.org/term/DOID:0050486", "evidence": [ { "id": "0050486", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050486" } ], "weight": 0.0 }, { "disease_id": "DOID:0060061", "name": "primary cutaneous T-cell non-Hodgkin lymphoma", "description": "A peripheral T-cell lymphoma that has_material_basis_in a mutation of T cells.", "url": "https://disease-ontology.org/term/DOID:0060061", "evidence": [ { "id": "0060061", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060061" } ], "weight": 0.0 }, { "disease_id": "DOID:11168", "name": "anogenital venereal wart", "description": "A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, or throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.", "url": "https://disease-ontology.org/term/DOID:11168", "evidence": [ { "id": "11168", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11168" } ], "weight": 0.0 }, { "disease_id": "DOID:11729", "name": "Lyme disease", "description": "A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system.", "url": "https://disease-ontology.org/term/DOID:11729", "evidence": [ { "id": "11729", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11729" } ], "weight": 0.0 }, { "disease_id": "DOID:1564", "name": "fungal infectious disease", "description": "A disease by infectious agent that results_in infection, has_material_basis_in Fungi, which pass the resistance barriers of the human or animal body.", "url": "https://disease-ontology.org/term/DOID:1564", "evidence": [ { "id": "1564", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1564" } ], "weight": 0.0 }, { "disease_id": "DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas.", "url": "https://disease-ontology.org/term/DOID:1793", "evidence": [ { "id": "1793", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ], "weight": 0.0 }, { "disease_id": "DOID:2722", "name": "acrodermatitis", "description": "A dermatitis that selectively affects the hands and feet.", "url": "https://disease-ontology.org/term/DOID:2722", "evidence": [ { "id": "2722", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2722" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:2986", "name": "IgA glomerulonephritis", "description": "A glomerulonephritis characterized by build up of IgA antibody in the glomerulus.", "url": "https://disease-ontology.org/term/DOID:2986", "evidence": [ { "id": "2986", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2986" } ], "weight": 0.0 }, { "disease_id": "DOID:3178", "name": "skin papilloma", "description": "A skin benign neoplasm that is composed of epithelial cells and a fibrous stalk.", "url": "https://disease-ontology.org/term/DOID:3178", "evidence": [ { "id": "3178", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3178" } ], "weight": 0.0 }, { "disease_id": "DOID:3310", "name": "atopic dermatitis", "description": "An allergic contact dermatitis that is a chronically relapsing inflammatory allergic response located_in the skin that causes itching and flaking.", "url": "https://disease-ontology.org/term/DOID:3310", "evidence": [ { "id": "3310", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3310" } ], "weight": 0.0 }, { "disease_id": "DOID:418", "name": "systemic scleroderma", "description": "A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.", "url": "https://disease-ontology.org/term/DOID:418", "evidence": [ { "id": "418", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:418" } ], "weight": 0.0 }, { "disease_id": "DOID:8893", "name": "psoriasis", "description": "A skin disease that is characterized by patches of thick red skin and silvery scales.", "url": "https://disease-ontology.org/term/DOID:8893", "evidence": [ { "id": "8893", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8893" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PJ26", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PJ26" } ], "pmid": "" } ], "biological_process": [ { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PJ26", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PJ26" } ], "pmid": "" }, { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PJ26", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PJ26" } ], "pmid": "" } ], "molecular_function": [ { "name": "chemokine activity", "id": "GO:0008009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008009", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PJ26", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PJ26" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.zebrafish.3" }, { "uniprot_canonical_ac": "A0A8M9PJ89-1", "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PJ89", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PJ89" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "length": 904, "chemical_mass": 100414.0, "gene_names": "fnip2;fnip2;si:ch211-42i9.8", "protein_name": "", "disease": [], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PJ89", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PJ89" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PJ89", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PJ89" } ], "pmid": "" } ], "molecular_function": [ { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PJ89", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PJ89" } ], "pmid": "" }, { "name": "ATPase inhibitor activity", "id": "GO:0042030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042030", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PJ89", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PJ89" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.zebrafish.3" }, { "uniprot_canonical_ac": "A0A8M9PJB1-1", "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PJB1", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PJB1" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "length": 1873, "chemical_mass": 209389.0, "gene_names": "nsd1b;nsd1b", "protein_name": "Histone-lysine N-methyltransferase, H3 lysine-36 specific", "disease": [ { "disease_id": "DOID:0112103", "name": "Sotos syndrome 1", "description": "A Sotos syndrome that has_material_basis_in heterozygous mutation in the NSD1 gene or deletion in the chromosome region 5q35 that includes the NSD1 gene.", "url": "https://disease-ontology.org/term/DOID:0112103", "evidence": [ { "id": "0112103", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0112103" } ], "weight": 0.0 }, { "disease_id": "DOID:10907", "name": "microcephaly", "description": "A congenital nervous system abnormality that is characterized by a significantly smaller than normal head in infants.", "url": "https://disease-ontology.org/term/DOID:10907", "evidence": [ { "id": "10907", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10907" } ], "weight": 0.0 }, { "disease_id": "DOID:14748", "name": "Sotos syndrome", "description": "A syndrome that occurs rarely and is characterized by excessive physical growth during the first 2 to 3 years of life.", "url": "https://disease-ontology.org/term/DOID:14748", "evidence": [ { "id": "14748", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14748" } ], "weight": 0.0 }, { "disease_id": "DOID:225", "name": "syndrome", "description": "A disease characterized by a group of signs and symptoms that occur together and characterize a particular abnormality.", "url": "https://disease-ontology.org/term/DOID:225", "evidence": [ { "id": "225", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:225" } ], "weight": 0.0 }, { "disease_id": "DOID:769", "name": "neuroblastoma", "description": "An autonomic nervous system neoplasm that derives_from immature nerve cells.", "url": "https://disease-ontology.org/term/DOID:769", "evidence": [ { "id": "769", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:769" } ], "weight": 0.0 }, { "disease_id": "DOID:9119", "name": "acute myeloid leukemia", "description": "A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.", "url": "https://disease-ontology.org/term/DOID:9119", "evidence": [ { "id": "9119", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9119" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PJB1", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PJB1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PJB1", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PJB1" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PJB1", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PJB1" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PJB1", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PJB1" } ], "pmid": "" } ], "biological_process": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PJB1", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PJB1" } ], "pmid": "" }, { "name": 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"url": "https://www.alliancegenome.org/disease/DOID:1925" } ], "weight": 0.0 }, { "disease_id": "DOID:219", "name": "colon cancer", "description": "A colorectal cancer that is located_in the colon.", "url": "https://disease-ontology.org/term/DOID:219", "evidence": [ { "id": "219", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:219" } ], "weight": 0.0 }, { "disease_id": "DOID:2870", "name": "endometrial adenocarcinoma", "description": "An endometrial carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:2870", "evidence": [ { "id": "2870", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2870" } ], "weight": 0.0 }, { "disease_id": "DOID:3717", "name": "gastric adenocarcinoma", "description": "A stomach carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:3717", "evidence": [ { "id": "3717", "database": "AGR", "url": 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"https://www.alliancegenome.org/disease/DOID:0080832" } ], "weight": 0.0 }, { "disease_id": "DOID:0110149", "name": "Charcot-Marie-Tooth disease type 1F", "description": "A Charcot-Marie-Tooth disease type 1 that has_material_basis_in mutation in the NEFL gene.", "url": "https://disease-ontology.org/term/DOID:0110149", "evidence": [ { "id": "0110149", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110149" } ], "weight": 0.0 }, { "disease_id": "DOID:0110165", "name": "Charcot-Marie-Tooth disease type 2E", "description": "A Charcot-Marie-Tooth disease type 2 that has_material_basis_in heterozygous mutation in the light polypeptide neurofilament protein gene (NEFL) on chromosome 8p21.", "url": "https://disease-ontology.org/term/DOID:0110165", "evidence": [ { "id": "0110165", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110165" } ], "weight": 0.0 }, { "disease_id": "DOID:10595", "name": "Charcot-Marie-Tooth disease", "description": "A neuromuscular disease that is characterized by a slowly progressive degeneration of the muscles of the foot, lower leg, hand and forearm.", "url": "https://disease-ontology.org/term/DOID:10595", "evidence": [ { "id": "10595", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10595" } ], "weight": 0.0 }, { "disease_id": "DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.", "url": "https://disease-ontology.org/term/DOID:10652", "evidence": [ { "id": "10652", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ], "weight": 0.0 }, { "disease_id": "DOID:11446", "name": "sciatic neuropathy", "description": "", "url": "https://disease-ontology.org/term/DOID:11446", "evidence": [ { "id": "11446", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11446" } ], "weight": 0.0 }, { "disease_id": "DOID:11949", "name": "Creutzfeldt-Jakob disease", "description": "", "url": "https://disease-ontology.org/term/DOID:11949", "evidence": [ { "id": "11949", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11949" } ], "weight": 0.0 }, { "disease_id": "DOID:12217", "name": "Lewy body dementia", "description": "A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities that has_material_basis_in accumulation of alpha-synuclein, SCNA, (protein). The causal mutation might be in SCNA or SCNB or some other gene(s) but the end result is always accumulation of SCNA in Lewy bodies.", "url": "https://disease-ontology.org/term/DOID:12217", "evidence": [ { "id": "12217", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12217" } ], "weight": 0.0 }, { "disease_id": "DOID:12894", "name": "Sjogren's syndrome", "description": "An autoimmune disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva.", "url": "https://disease-ontology.org/term/DOID:12894", "evidence": [ { "id": "12894", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12894" } ], "weight": 0.0 }, { "disease_id": "DOID:14330", "name": "Parkinson's disease", "description": "A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.", "url": "https://disease-ontology.org/term/DOID:14330", "evidence": [ { "id": "14330", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14330" } ], "weight": 0.0 }, { "disease_id": "DOID:1459", "name": "hypothyroidism", "description": "A thyroid gland disease which involves an underproduction of thyroid hormone.", "url": "https://disease-ontology.org/term/DOID:1459", "evidence": [ { "id": "1459", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1459" } ], "weight": 0.0 }, { "disease_id": "DOID:1596", "name": "depressive disorder", "description": "A mood disorder characterized by persistent sadness, emptiness, or irritability and decreased ability to function.", "url": "https://disease-ontology.org/term/DOID:1596", "evidence": [ { "id": "1596", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1596" } ], "weight": 0.0 }, { "disease_id": "DOID:224", "name": "transient cerebral ischemia", "description": "A brain ischemia that is characterized by ischemia of brief duration and without resultant tissue death.", "url": "https://disease-ontology.org/term/DOID:224", "evidence": [ { "id": "224", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:224" } ], "weight": 0.0 }, { "disease_id": "DOID:2377", "name": "multiple sclerosis", "description": "A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.", "url": "https://disease-ontology.org/term/DOID:2377", "evidence": [ { "id": "2377", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2377" } ], "weight": 0.0 }, { "disease_id": "DOID:2378", "name": "relapsing-remitting multiple sclerosis", "description": "A multiple sclerosis that is characterized by relapse (attacks of symptom flare-ups) followed by remission (periods of recovery). Symptoms may vary from mild to severe, and relapses and remissions may last for days or months. More than 80 percent of people who have MS begin with relapsing-remitting cycles.", "url": "https://disease-ontology.org/term/DOID:2378", "evidence": [ { "id": "2378", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2378" } ], "weight": 0.0 }, { "disease_id": "DOID:3008", "name": "invasive ductal carcinoma", "description": "A breast ductal carcinoma that is characterized by infiltration into the fibrous or fatty tissue of the breast outside of the duct where it originated.", "url": "https://disease-ontology.org/term/DOID:3008", "evidence": [ { "id": "3008", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3008" } ], "weight": 0.0 }, { "disease_id": "DOID:3213", "name": "demyelinating disease", "description": "A central nervous system disease that is characterized by damage to the myelin sheath present around nerve axons.", "url": "https://disease-ontology.org/term/DOID:3213", "evidence": [ { "id": "3213", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3213" } ], "weight": 0.0 }, { "disease_id": "DOID:332", "name": "amyotrophic lateral sclerosis", "description": "A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.", "url": "https://disease-ontology.org/term/DOID:332", "evidence": [ { "id": "332", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:332" } ], "weight": 0.0 }, { "disease_id": "DOID:4166", "name": "syphilis", "description": "A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.", "url": "https://disease-ontology.org/term/DOID:4166", "evidence": [ { "id": "4166", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4166" } ], "weight": 0.0 }, { "disease_id": "DOID:526", "name": "human immunodeficiency virus infectious disease", "description": "A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 (Lentivirus humimdef1) or Human immunodeficiency virus 2 (Lentivirus humimdef2), which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.", "url": "https://disease-ontology.org/term/DOID:526", "evidence": [ { "id": "526", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:526" } ], "weight": 0.0 }, { "disease_id": "DOID:639", "name": "acute disseminated encephalomyelitis", "description": "An encephalomyelitis characterized by inflammation located in brain and located in spinal cord that damages myelin. It usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection.", "url": "https://disease-ontology.org/term/DOID:639", "evidence": [ { "id": "639", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:639" } ], "weight": 0.0 }, { "disease_id": "DOID:643", "name": "progressive multifocal leukoencephalopathy", "description": "A viral infectious disease that involves reactivation of JC polyomavirus (Betapolyomavirus secuhominis) in immune-compromised individuals which causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain. The symptoms include hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment and coma.", "url": "https://disease-ontology.org/term/DOID:643", "evidence": [ { "id": "643", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:643" } ], "weight": 0.0 }, { "disease_id": "DOID:8725", "name": "vascular dementia", "description": "A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.", "url": "https://disease-ontology.org/term/DOID:8725", "evidence": [ { "id": "8725", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8725" } ], "weight": 0.0 }, { "disease_id": "DOID:8869", "name": "neuromyelitis optica", "description": "A central nervous system disease characterized by inflammation of the optic nerve (optic neuritis) and inflammation of the spinal cord (myelitis).", "url": "https://disease-ontology.org/term/DOID:8869", "evidence": [ { "id": "8869", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8869" } ], "weight": 0.0 }, { "disease_id": "DOID:9255", "name": "frontotemporal dementia", "description": "A dementia characterized by progressive neuronal loss predominantly involving the frontal and/or temporal lobes of the brain resulting in a gradual and progressive decline in behavior or language.", "url": "https://disease-ontology.org/term/DOID:9255", "evidence": [ { "id": "9255", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9255" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PUK6", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PUK6" } ], "pmid": "" }, { "name": "intermediate filament", "id": "GO:0005882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005882", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PUK6", "url": 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"cellular_component": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PUN0", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PUN0" } ], "pmid": "" }, { "name": "trans-Golgi network membrane", "id": "GO:0032588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032588", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PUN0", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PUN0" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PUN0", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PUN0" } ], "pmid": "" } ], "molecular_function": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9PUN0", "url": 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