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"A colorectal cancer that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa.", "url": "https://disease-ontology.org/term/DOID:0080199", "evidence": [ { "id": "0080199", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080199" } ], "weight": 0.0 }, { "disease_id": "DOID:10286", "name": "prostate carcinoma", "description": "A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.", "url": "https://disease-ontology.org/term/DOID:10286", "evidence": [ { "id": "10286", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10286" } ], "weight": 0.0 }, { "disease_id": "DOID:10591", "name": "pre-eclampsia", "description": "A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy.", "url": "https://disease-ontology.org/term/DOID:10591", "evidence": [ { "id": "10591", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10591" } ], "weight": 0.0 }, { "disease_id": "DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries.", "url": "https://disease-ontology.org/term/DOID:10763", "evidence": [ { "id": "10763", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ], "weight": 0.0 }, { "disease_id": "DOID:11650", "name": "bronchopulmonary dysplasia", "description": "A lung disease that is characterized by underdeveloped lungs in newborns that can be easily irritated or inflamed after birth resulting in damage to the alveoli of the lungs and bronchi. Most newborns who develop BPD are born more than 10 weeks before their due dates, weigh less than 2 pounds at birth, and have breathing problems.", "url": "https://disease-ontology.org/term/DOID:11650", "evidence": [ { "id": "11650", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11650" } ], "weight": 0.0 }, { "disease_id": "DOID:13375", "name": "temporal arteritis", "description": "A central nervous system vasculitis that is characterized by inflammation of the lining of arteries, often arteries in the head.", "url": "https://disease-ontology.org/term/DOID:13375", "evidence": [ { "id": "13375", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13375" } ], "weight": 0.0 }, { "disease_id": "DOID:13406", "name": "pulmonary sarcoidosis", "description": "A sarcoidosis that is characterized by noncaseating granulomatous infiltration of the lungs and supporting lymph nodes, bilateral hilar adenopathy, and pulmonary issues, has_symptom shortness of breath, fatigue, wheezing, and chronic cough, and develops_from a type IV hypersensitivity reaction.", "url": "https://disease-ontology.org/term/DOID:13406", "evidence": [ { "id": "13406", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13406" } ], "weight": 0.0 }, { "disease_id": "DOID:1380", "name": "endometrial cancer", "description": "A uterine cancer that is located_in tissues lining the uterus.", "url": "https://disease-ontology.org/term/DOID:1380", "evidence": [ { "id": "1380", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1380" } ], "weight": 0.0 }, { "disease_id": "DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland.", "url": "https://disease-ontology.org/term/DOID:1612", "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ], "weight": 0.0 }, { "disease_id": "DOID:1909", "name": "melanoma", "description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye.", "url": "https://disease-ontology.org/term/DOID:1909", "evidence": [ { "id": "1909", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1909" } ], "weight": 0.0 }, { "disease_id": "DOID:2349", "name": "arteriosclerosis", "description": "An artery disease that is characterized by a thickening and hardening of arterial walls in the arteries.", "url": "https://disease-ontology.org/term/DOID:2349", "evidence": [ { "id": "2349", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2349" } ], "weight": 0.0 }, { "disease_id": "DOID:2378", "name": "relapsing-remitting multiple sclerosis", "description": "A multiple sclerosis that is characterized by relapse (attacks of symptom flare-ups) followed by remission (periods of recovery). Symptoms may vary from mild to severe, and relapses and remissions may last for days or months. More than 80 percent of people who have MS begin with relapsing-remitting cycles.", "url": "https://disease-ontology.org/term/DOID:2378", "evidence": [ { "id": "2378", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2378" } ], "weight": 0.0 }, { "disease_id": "DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary.", "url": "https://disease-ontology.org/term/DOID:2394", "evidence": [ { "id": "2394", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2394" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:3068", "name": "glioblastoma", "description": "A malignant astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes.", "url": "https://disease-ontology.org/term/DOID:3068", "evidence": [ { "id": "3068", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3068" } ], "weight": 0.0 }, { "disease_id": "DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:3371", "name": "chondrosarcoma", "description": "A bone sarcoma that has_material_basis_in cells derived from transformed cells that produce cartilage.", "url": "https://disease-ontology.org/term/DOID:3371", "evidence": [ { "id": "3371", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3371" } ], "weight": 0.0 }, { "disease_id": "DOID:3393", "name": "coronary artery disease", "description": "An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.", "url": "https://disease-ontology.org/term/DOID:3393", "evidence": [ { "id": "3393", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3393" } ], "weight": 0.0 }, { "disease_id": "DOID:3770", "name": "pulmonary fibrosis", "description": "An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation. It can be caused by inhaling hazardous chemicals, certain diseases, medication and genetics or unknown causes.", "url": "https://disease-ontology.org/term/DOID:3770", "evidence": [ { "id": "3770", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3770" } ], "weight": 0.0 }, { "disease_id": "DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.", "url": "https://disease-ontology.org/term/DOID:3908", "evidence": [ { "id": "3908", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ], "weight": 0.0 }, { "disease_id": "DOID:418", "name": "systemic scleroderma", "description": "A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.", "url": "https://disease-ontology.org/term/DOID:418", "evidence": [ { "id": "418", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:418" } ], "weight": 0.0 }, { "disease_id": "DOID:5419", "name": "schizophrenia", "description": "A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness.", "url": "https://disease-ontology.org/term/DOID:5419", "evidence": [ { "id": "5419", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5419" } ], "weight": 0.0 }, { "disease_id": "DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.", "url": "https://disease-ontology.org/term/DOID:5844", "evidence": [ { "id": "5844", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ], "weight": 0.0 }, { "disease_id": "DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.", "url": "https://disease-ontology.org/term/DOID:6000", "evidence": [ { "id": "6000", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ], "weight": 0.0 }, { "disease_id": "DOID:7148", "name": "rheumatoid arthritis", "description": "An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.", "url": "https://disease-ontology.org/term/DOID:7148", "evidence": [ { "id": "7148", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:7148" } ], "weight": 0.0 }, { "disease_id": "DOID:8869", "name": "neuromyelitis optica", "description": "A central nervous system disease characterized by inflammation of the optic nerve (optic neuritis) and inflammation of the spinal cord (myelitis).", "url": "https://disease-ontology.org/term/DOID:8869", "evidence": [ { "id": "8869", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8869" } ], "weight": 0.0 }, { "disease_id": "DOID:9119", "name": "acute myeloid leukemia", "description": "A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.", "url": "https://disease-ontology.org/term/DOID:9119", "evidence": [ { "id": "9119", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9119" } ], "weight": 0.0 }, { "disease_id": "DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.", "url": "https://disease-ontology.org/term/DOID:9352", "evidence": [ { "id": "9352", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ], "weight": 0.0 }, { "disease_id": "DOID:9470", "name": "bacterial meningitis", "description": "A meningitis that has_material_basis_in a bacterial infection.", "url": "https://disease-ontology.org/term/DOID:9470", "evidence": [ { "id": "9470", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9470" } ], "weight": 0.0 }, { "disease_id": "DOID:9538", "name": "multiple myeloma", "description": "A myeloid neoplasm that is located_in the plasma cells in bone marrow.", "url": "https://disease-ontology.org/term/DOID:9538", "evidence": [ { "id": "9538", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9538" } ], "weight": 0.0 }, { "disease_id": "DOID:9744", "name": "type 1 diabetes mellitus", "description": "A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production.", "url": "https://disease-ontology.org/term/DOID:9744", "evidence": [ { "id": "9744", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9744" } ], "weight": 0.0 } ], "cellular_component": [ { "name": 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The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:3068", "name": "glioblastoma", "description": "A malignant astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes.", "url": "https://disease-ontology.org/term/DOID:3068", "evidence": [ { "id": "3068", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3068" } ], "weight": 0.0 }, { "disease_id": "DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:3371", "name": "chondrosarcoma", "description": "A bone sarcoma that has_material_basis_in cells derived from transformed cells that produce cartilage.", "url": "https://disease-ontology.org/term/DOID:3371", "evidence": [ { "id": "3371", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3371" } ], "weight": 0.0 }, { "disease_id": "DOID:3393", "name": "coronary artery disease", "description": "An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.", "url": "https://disease-ontology.org/term/DOID:3393", "evidence": [ { "id": "3393", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3393" } ], "weight": 0.0 }, { "disease_id": "DOID:3770", "name": "pulmonary fibrosis", "description": "An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation. It can be caused by inhaling hazardous chemicals, certain diseases, medication and genetics or unknown causes.", "url": "https://disease-ontology.org/term/DOID:3770", "evidence": [ { "id": "3770", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3770" } ], "weight": 0.0 }, { "disease_id": "DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.", "url": "https://disease-ontology.org/term/DOID:3908", "evidence": [ { "id": "3908", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ], "weight": 0.0 }, { "disease_id": "DOID:418", "name": "systemic scleroderma", "description": "A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.", "url": "https://disease-ontology.org/term/DOID:418", "evidence": [ { "id": "418", "database": 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disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.", "url": "https://disease-ontology.org/term/DOID:6000", "evidence": [ { "id": "6000", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ], "weight": 0.0 }, { "disease_id": "DOID:7148", "name": "rheumatoid arthritis", "description": "An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.", "url": "https://disease-ontology.org/term/DOID:7148", "evidence": [ { "id": "7148", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:7148" } ], "weight": 0.0 }, { "disease_id": "DOID:8869", "name": "neuromyelitis optica", "description": "A central nervous system disease characterized by inflammation of the optic nerve (optic neuritis) and inflammation of the spinal cord (myelitis).", "url": "https://disease-ontology.org/term/DOID:8869", "evidence": [ { "id": "8869", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8869" } ], "weight": 0.0 }, { "disease_id": "DOID:9119", "name": "acute myeloid leukemia", "description": "A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.", "url": "https://disease-ontology.org/term/DOID:9119", "evidence": [ { "id": "9119", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9119" } ], "weight": 0.0 }, { "disease_id": "DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.", "url": "https://disease-ontology.org/term/DOID:9352", "evidence": [ { "id": "9352", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ], "weight": 0.0 }, { "disease_id": "DOID:9470", "name": "bacterial meningitis", "description": "A meningitis that has_material_basis_in a bacterial infection.", "url": "https://disease-ontology.org/term/DOID:9470", "evidence": [ { "id": "9470", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9470" } ], "weight": 0.0 }, { "disease_id": "DOID:9538", "name": "multiple myeloma", "description": "A myeloid neoplasm that is located_in the plasma cells in bone marrow.", "url": "https://disease-ontology.org/term/DOID:9538", "evidence": [ { "id": "9538", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9538" } ], "weight": 0.0 }, { "disease_id": "DOID:9744", "name": "type 1 diabetes mellitus", "description": "A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production.", "url": "https://disease-ontology.org/term/DOID:9744", "evidence": [ { "id": "9744", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9744" } ], "weight": 0.0 } ], "cellular_component": [ { "name": 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"uniprot_canonical_ac": "Q9V3W0-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V3W0", "url": "https://www.uniprot.org/uniprotkb/Q9V3W0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 138, "chemical_mass": 14876.0, "gene_names": "UK114;BG:DS07851.3;BcDNA:GM01181;CG15261;DUK 114;DUK114;Dmel\\CG15261;UK114", "protein_name": "RutC family protein UK114", "disease": [], "cellular_component": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q9V3W0", "url": "https://www.uniprot.org/uniprotkb/Q9V3W0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q9V3W0", "url": "https://www.uniprot.org/uniprotkb/Q9V3W0" } ], "pmid": "" } ], "biological_process": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "Q9V3W0", "url": "https://www.uniprot.org/uniprotkb/Q9V3W0" } ], "pmid": "" }, { "name": "negative regulation of translation", "id": "GO:0017148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017148", "evidence": [ { "database": "UniProtKB", "id": "Q9V3W0", "url": "https://www.uniprot.org/uniprotkb/Q9V3W0" } ], "pmid": "" }, { "name": "mRNA catabolic process", "id": "GO:0006402", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006402", "evidence": [ { "database": "UniProtKB", "id": "Q9V3W0", "url": "https://www.uniprot.org/uniprotkb/Q9V3W0" } ], "pmid": "" } ], "molecular_function": [ { "name": "deaminase activity", "id": "GO:0019239", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019239", "evidence": [ { "database": "UniProtKB", "id": "Q9V3W0", "url": "https://www.uniprot.org/uniprotkb/Q9V3W0" } ], "pmid": "" }, { "name": "protein folding chaperone", "id": "GO:0044183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044183", "evidence": [ { "database": "UniProtKB", "id": "Q9V3W0", "url": "https://www.uniprot.org/uniprotkb/Q9V3W0" } ], "pmid": "" }, { "name": "2-iminobutanoate deaminase activity", "id": "GO:0120242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120242", "evidence": [ { "database": "UniProtKB", "id": "Q9V3W0", "url": "https://www.uniprot.org/uniprotkb/Q9V3W0" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9V3W6-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V3W6", "url": "https://www.uniprot.org/uniprotkb/Q9V3W6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 438, "chemical_mass": 50669.0, "gene_names": 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"relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 392, "start_aa": "Thr", "end_pos": 392, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr392", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ] } ], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9V3Z1-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprotkb/Q9V3Z1" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 484, "chemical_mass": 54077.0, "gene_names": "trbl;CG5408;Dmel\\CG5408;Trbl;trbl;trb", "protein_name": "Tribbles", "disease": [ { "disease_id": "DOID:4194", "name": "glucose metabolism disease", "description": "A carbohydrate metabolic disorder that is characterized by blood glucose levels which cannot be maintained within the normal 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} ] }, { "uniprot_canonical_ac": "Q9VA38-1", "start_pos": "444", "end_pos": "444", "site_lbl": "Thr444", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 444, "start_aa": "Thr", "end_pos": 444, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr444", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ] } ], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VAG4-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VAG4", "url": "https://www.uniprot.org/uniprotkb/Q9VAG4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": 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"chemical_mass": 65387.0, "gene_names": "Ndc1;CG5857;Dmel\\CG5857;NDC1;Ndc1;ndc1", "protein_name": "Nucleoporin Ndc1", "disease": [], "cellular_component": [ { "name": "nuclear pore transmembrane ring", "id": "GO:0070762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070762", "evidence": [ { "database": "UniProtKB", "id": "Q9VCG4", "url": "https://www.uniprot.org/uniprotkb/Q9VCG4" } ], "pmid": "" }, { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "Q9VCG4", "url": "https://www.uniprot.org/uniprotkb/Q9VCG4" } ], "pmid": "" }, { "name": "nuclear pore", "id": "GO:0005643", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005643", "evidence": [ { "database": "UniProtKB", "id": "Q9VCG4", "url": "https://www.uniprot.org/uniprotkb/Q9VCG4" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "Q9VCG4", "url": "https://www.uniprot.org/uniprotkb/Q9VCG4" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "Q9VCG4", "url": "https://www.uniprot.org/uniprotkb/Q9VCG4" } ], "pmid": "" } ], "biological_process": [ { "name": "nuclear pore organization", "id": "GO:0006999", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006999", "evidence": [ { "database": "UniProtKB", "id": "Q9VCG4", "url": "https://www.uniprot.org/uniprotkb/Q9VCG4" } ], "pmid": "" }, { "name": "nucleocytoplasmic transport", "id": "GO:0006913", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006913", "evidence": [ { "database": "UniProtKB", "id": "Q9VCG4", "url": "https://www.uniprot.org/uniprotkb/Q9VCG4" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q9VCG4", "url": "https://www.uniprot.org/uniprotkb/Q9VCG4" } ], "pmid": "" }, { "name": "nuclear pore complex assembly", "id": "GO:0051292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051292", "evidence": [ { "database": "UniProtKB", "id": "Q9VCG4", "url": "https://www.uniprot.org/uniprotkb/Q9VCG4" } ], "pmid": "" }, { "name": "mRNA transport", "id": "GO:0051028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051028", "evidence": [ { "database": "UniProtKB", "id": "Q9VCG4", "url": "https://www.uniprot.org/uniprotkb/Q9VCG4" } ], "pmid": "" } ], "molecular_function": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "Q9VCG4", "url": "https://www.uniprot.org/uniprotkb/Q9VCG4" } ], "pmid": "" }, { "name": "structural constituent of nuclear pore", "id": "GO:0017056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017056", "evidence": [ { "database": "UniProtKB", "id": "Q9VCG4", "url": "https://www.uniprot.org/uniprotkb/Q9VCG4" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "Q9VCG4-1", "start_pos": "414", "end_pos": "414", "site_lbl": "Ser414", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "UniProtKB", "id": "Q9VCG4", "url": "https://www.uniprot.org/uniprotkb/Q9VCG4" }, { "database": "PubMed", "id": "18327897", "url": "https://glygen.org/publication/PubMed/18327897" }, { "database": "iPTMnet", "id": "Q9VCG4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9VCG4" } ] } ] } ], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VCH5-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 1960, "chemical_mass": 210139.0, "gene_names": "Nup98-96;CG10198;CG10201;Dmel\\CG10198;NUP98-NUP96;NUP98;Nup 96;Nup 98;Nup-98;Nup145;Nup96-98;Nup96;Nup98-96;Nup98-Nup96;Nup98/96;Nup98;Nup;l(3)95BCd;nup145;nup98-96;nup98", "protein_name": "Nuclear pore complex protein Nup98-Nup96", "disease": [ { "disease_id": "DOID:5603", "name": "T-cell acute lymphoblastic leukemia", "description": "An acute lymphoblastic leukemia that is characterized by too many T-cell lymphoblasts found in the bone marrow and blood.", "url": "https://disease-ontology.org/term/DOID:5603", "evidence": [ { "id": "5603", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5603" } ], "weight": 0.0 }, { "disease_id": "DOID:9119", "name": "acute myeloid leukemia", "description": "A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.", "url": "https://disease-ontology.org/term/DOID:9119", "evidence": [ { "id": "9119", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9119" } ], "weight": 0.0 } ], "biological_process": [ { "name": "positive regulation of transcription initiation by RNA polymerase II", "id": "GO:0060261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060261", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "nucleocytoplasmic transport", "id": "GO:0006913", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006913", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "regulation of nucleocytoplasmic transport", "id": "GO:0046822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046822", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "cellular response to heat", "id": "GO:0034605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034605", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "positive regulation of defense response to virus by host", "id": "GO:0002230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002230", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "host-mediated suppression of viral transcription", "id": "GO:0043922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043922", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "mRNA transport", "id": "GO:0051028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051028", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery", "id": "GO:0000973", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000973", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "telomere tethering at nuclear periphery", "id": "GO:0034398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034398", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "RNA export from nucleus", "id": "GO:0006405", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006405", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "protein import into nucleus", "id": "GO:0006606", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006606", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "response to ecdysone", "id": "GO:0035075", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035075", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "heat shock-mediated polytene chromosome puffing", "id": "GO:0035080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035080", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "cellular response to ecdysone", "id": "GO:0071390", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071390", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" } ], "molecular_function": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "serine hydrolase activity", "id": "GO:0017171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017171", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "chromatin DNA binding", "id": "GO:0031490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031490", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "structural constituent of nuclear pore", "id": "GO:0017056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017056", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "nuclear localization sequence binding", "id": "GO:0008139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008139", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "serine-type peptidase activity", "id": "GO:0008236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008236", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "promoter-specific chromatin binding", "id": "GO:1990841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990841", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "promoter-enhancer loop anchoring activity", "id": "GO:0140585", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140585", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "nuclear pore", "id": "GO:0005643", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005643", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "nuclear pore cytoplasmic filaments", "id": "GO:0044614", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044614", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "nuclear pore central transport channel", "id": "GO:0044613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044613", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "polytene chromosome", "id": "GO:0005700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005700", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "polytene chromosome puff", "id": "GO:0005703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005703", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" }, { "name": "polytene chromosome band", "id": "GO:0005704", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005704", "evidence": [ { "database": "UniProtKB", "id": "Q9VCH5", "url": "https://www.uniprot.org/uniprotkb/Q9VCH5" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "Q9VCH5-1", "start_pos": "12", "end_pos": "12", "site_lbl": "Thr12", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 12, "start_aa": "Thr", "end_pos": 12, "end_aa": "Thr", "residue": "Thr", 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"" }, { "name": "bicoid mRNA localization", "id": "GO:0045450", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045450", "evidence": [ { "database": "UniProtKB", "id": "Q9VD72", "url": "https://www.uniprot.org/uniprotkb/Q9VD72" } ], "pmid": "" } ], "cellular_component": [ { "name": "ESCRT II complex", "id": "GO:0000814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000814", "evidence": [ { "database": "UniProtKB", "id": "Q9VD72", "url": "https://www.uniprot.org/uniprotkb/Q9VD72" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VDD9-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VDD9", "url": "https://www.uniprot.org/uniprotkb/Q9VDD9" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 320, "chemical_mass": 36226.0, "gene_names": 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"https://www.ebi.ac.uk/QuickGO/term/GO:1990748", "evidence": [ { "database": "UniProtKB", "id": "Q9VDN2", "url": "https://www.uniprot.org/uniprotkb/Q9VDN2" } ], "pmid": "" }, { "name": "cellular detoxification of metal ion", "id": "GO:0140961", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140961", "evidence": [ { "database": "UniProtKB", "id": "Q9VDN2", "url": "https://www.uniprot.org/uniprotkb/Q9VDN2" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VDQ7-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VDQ7", "url": "https://www.uniprot.org/uniprotkb/Q9VDQ7" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 948, "chemical_mass": 109110.0, "gene_names": "psidin;CG4845;Dmel\\CG4845;Naa25;dNAA25;ird16;psidin;psid;psif", "protein_name": "Phagocyte signaling-impaired protein", "disease": [], "biological_process": [ { "name": "activation of immune response", "id": "GO:0002253", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002253", "evidence": [ { "database": "UniProtKB", "id": "Q9VDQ7", "url": "https://www.uniprot.org/uniprotkb/Q9VDQ7" } ], "pmid": "" }, { "name": "phagocytosis, engulfment", "id": "GO:0006911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006911", "evidence": [ { "database": "UniProtKB", "id": "Q9VDQ7", "url": "https://www.uniprot.org/uniprotkb/Q9VDQ7" } ], "pmid": "" }, { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "Q9VDQ7", "url": "https://www.uniprot.org/uniprotkb/Q9VDQ7" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "Q9VDQ7", "url": "https://www.uniprot.org/uniprotkb/Q9VDQ7" } ], "pmid": "" }, { "name": "negative regulation of neuron apoptotic process", "id": "GO:0043524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043524", "evidence": [ { "database": "UniProtKB", "id": "Q9VDQ7", "url": "https://www.uniprot.org/uniprotkb/Q9VDQ7" } ], "pmid": "" }, { "name": "cytoskeleton organization", "id": "GO:0007010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "evidence": [ { "database": "UniProtKB", "id": "Q9VDQ7", "url": "https://www.uniprot.org/uniprotkb/Q9VDQ7" } ], "pmid": "" }, { "name": "positive regulation of lamellipodium assembly", "id": "GO:0010592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010592", "evidence": [ { "database": "UniProtKB", "id": "Q9VDQ7", "url": "https://www.uniprot.org/uniprotkb/Q9VDQ7" } ], "pmid": "" }, { "name": "sensory neuron axon guidance", "id": "GO:0097374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097374", "evidence": [ { "database": "UniProtKB", "id": "Q9VDQ7", "url": "https://www.uniprot.org/uniprotkb/Q9VDQ7" } ], "pmid": "" }, { "name": "actin filament depolymerization", "id": "GO:0030042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030042", "evidence": [ { "database": "UniProtKB", "id": "Q9VDQ7", "url": "https://www.uniprot.org/uniprotkb/Q9VDQ7" } ], "pmid": "" }, { "name": "border follicle cell migration", "id": "GO:0007298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007298", "evidence": [ { "database": "UniProtKB", "id": "Q9VDQ7", "url": "https://www.uniprot.org/uniprotkb/Q9VDQ7" } ], "pmid": "" } ], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9VDQ7", "url": "https://www.uniprot.org/uniprotkb/Q9VDQ7" } ], "pmid": "" }, { "name": "growth cone lamellipodium", "id": "GO:1990761", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990761", "evidence": [ { "database": "UniProtKB", "id": "Q9VDQ7", "url": "https://www.uniprot.org/uniprotkb/Q9VDQ7" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "Q9VDQ7", "url": "https://www.uniprot.org/uniprotkb/Q9VDQ7" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "Q9VDQ7", "url": "https://www.uniprot.org/uniprotkb/Q9VDQ7" } ], "pmid": "" }, { "name": "NatB complex", "id": "GO:0031416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031416", "evidence": [ { "database": "UniProtKB", "id": "Q9VDQ7", "url": "https://www.uniprot.org/uniprotkb/Q9VDQ7" } ], "pmid": "" } ], "molecular_function": [ { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "Q9VDQ7", "url": "https://www.uniprot.org/uniprotkb/Q9VDQ7" } ], "pmid": "" }, { "name": "acetyltransferase activator activity", "id": "GO:0010698", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010698", "evidence": [ { "database": "UniProtKB", "id": "Q9VDQ7", "url": "https://www.uniprot.org/uniprotkb/Q9VDQ7" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VDT6-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VDT6", "url": "https://www.uniprot.org/uniprotkb/Q9VDT6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 250, "chemical_mass": 28137.0, "gene_names": "Mrm2;CG11447;DmMRM2;Dmel\\CG11447;Mrm2", "protein_name": "rRNA methyltransferase 2, mitochondrial", "disease": [ { "disease_id": "DOID:0070448", "name": "mitochondrial DNA depletion syndrome 17", "description": "A mitochondrial DNA depletion syndrome characterized by childhood onset of encephalopathy, stroke-like episodes, lactic acidosis, hypocitrullinemia, and multiple mitochondrial oxidative phosphorylation deficiencies that has_material_basis_in homozygous mutation in the MRM2 gene on chromosome 7p22.3. Phenotype is similar to MELAS syndrome.", "url": "https://disease-ontology.org/term/DOID:0070448", "evidence": [ { "id": "0070448", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070448" } ], "weight": 0.0 }, { "disease_id": "DOID:3687", "name": "MELAS syndrome", "description": "A mitochondrial encephalomyopathy that is characterized by mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes, has_symptom myalgia, motor weakness, headaches, seizures, and stroke-like episodes with acute hemiparesis and severe headaches, and develops_from mutation in mitochondrial genes including MT-TL1, which encodes tRNA proteins.", "url": "https://disease-ontology.org/term/DOID:3687", "evidence": [ { "id": "3687", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3687" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q9VDT6", "url": "https://www.uniprot.org/uniprotkb/Q9VDT6" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q9VDT6", "url": "https://www.uniprot.org/uniprotkb/Q9VDT6" } ], "pmid": "" } ], "biological_process": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "Q9VDT6", "url": "https://www.uniprot.org/uniprotkb/Q9VDT6" } ], "pmid": "" }, { "name": "mitochondrial large ribosomal subunit assembly", "id": "GO:1902775", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902775", "evidence": [ { "database": "UniProtKB", "id": "Q9VDT6", "url": "https://www.uniprot.org/uniprotkb/Q9VDT6" } ], "pmid": "" }, { "name": "RNA methylation", "id": "GO:0001510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001510", "evidence": [ { "database": "UniProtKB", "id": "Q9VDT6", "url": "https://www.uniprot.org/uniprotkb/Q9VDT6" } ], "pmid": "" } ], "molecular_function": [ { "name": "rRNA (uridine-2'-O-)-methyltransferase activity", "id": "GO:0008650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008650", "evidence": [ { "database": "UniProtKB", "id": "Q9VDT6", "url": "https://www.uniprot.org/uniprotkb/Q9VDT6" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VE01-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VE01", "url": "https://www.uniprot.org/uniprotkb/Q9VE01" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 536, "chemical_mass": 61355.0, "gene_names": "Cyp12a5;12a5;CG11821;CYP12A5;CYP12a5;Cyp12A5;Cyp12a5;Dmel\\CG11821", "protein_name": "Probable cytochrome P450 12a5, mitochondrial", "disease": [ { "disease_id": "DOID:0050860", "name": "colorectal adenoma", "description": "An intestinal benign neoplasm that has_material_basis_in epithelial tissue of glandular origin and is located_in colon and located_in rectum.", "url": "https://disease-ontology.org/term/DOID:0050860", "evidence": [ { "id": "0050860", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050860" } ], "weight": 0.0 }, { "disease_id": "DOID:0050861", "name": "colorectal adenocarcinoma", "description": "A colorectal carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:0050861", "evidence": [ { "id": "0050861", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050861" } ], "weight": 0.0 }, { "disease_id": "DOID:0050866", "name": "oral squamous cell carcinoma", "description": "An oral cavity cancer that has_material_basis_in squamous cells.", "url": "https://disease-ontology.org/term/DOID:0050866", "evidence": [ { "id": "0050866", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050866" } ], "weight": 0.0 }, { "disease_id": "DOID:0061136", "name": "infantile hypercalcemia 1", "description": "A hypercalcemia that has_material_basis_in homozygous or compound heterozygous mutation in the CYP24A1 gene on chromosome 20q13.", "url": "https://disease-ontology.org/term/DOID:0061136", "evidence": [ { "id": "0061136", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0061136" } ], "weight": 0.0 }, { "disease_id": "DOID:0080547", "name": "metabolic dysfunction-associated steatohepatitis", "description": "A metabolic dysfunction-associated steatotic liver disease characterized by the presence of inflammation with hepatocyte injury such as ballooning, with or without fibrosis.", "url": "https://disease-ontology.org/term/DOID:0080547", "evidence": [ { "id": "0080547", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080547" } ], "weight": 0.0 }, { "disease_id": "DOID:0080815", "name": "childhood-onset asthma", "description": "A chronic asthma that is characterized by first presentation in early childhood.", "url": "https://disease-ontology.org/term/DOID:0080815", "evidence": [ { "id": "0080815", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080815" } ], "weight": 0.0 }, { "disease_id": "DOID:0080886", "name": "vitamin D-dependent rickets type 1A", "description": "A vitamin D-dependent rickets that is characterized by abnormally low levels of calcitriol and that has_material_basis_in mutation in the gene encoding 25-hydroxyvitamin D3-1-alpha-hydroxylase (CYP27B1) on chromosome 12q13.", "url": "https://disease-ontology.org/term/DOID:0080886", "evidence": [ { "id": "0080886", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080886" } ], "weight": 0.0 }, { "disease_id": "DOID:10591", "name": "pre-eclampsia", "description": "A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy.", "url": "https://disease-ontology.org/term/DOID:10591", "evidence": [ { "id": "10591", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10591" } ], "weight": 0.0 }, { "disease_id": "DOID:10609", "name": "rickets", "description": "A bone remodeling disease that has_material_basis_in impaired mineralization or calcification of bones before epiphyseal closure due to deficiency or impaired metabolism of vitamin D, phosphorus or calcium which results_in softening and deformity located_in bone.", "url": "https://disease-ontology.org/term/DOID:10609", "evidence": [ { "id": "10609", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10609" } ], "weight": 0.0 }, { "disease_id": "DOID:11714", "name": "gestational diabetes", "description": "A diabetes mellitus that manifests during pregnancy.", "url": "https://disease-ontology.org/term/DOID:11714", "evidence": [ { "id": "11714", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11714" } ], "weight": 0.0 }, { "disease_id": "DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung.", "url": "https://disease-ontology.org/term/DOID:1324", "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ], "weight": 0.0 }, { "disease_id": "DOID:13619", "name": "extrahepatic cholestasis", "description": "A cholestasis resulting from causes located_in bile ducts outside the liver.", "url": "https://disease-ontology.org/term/DOID:13619", "evidence": [ { "id": "13619", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13619" } ], "weight": 0.0 }, { "disease_id": "DOID:1574", "name": "alcohol use disorder", "description": "A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.", "url": "https://disease-ontology.org/term/DOID:1574", "evidence": [ { "id": "1574", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1574" } ], "weight": 0.0 }, { "disease_id": "DOID:1993", "name": "rectum cancer", "description": "A colorectal cancer that is located_in the rectum.", "url": "https://disease-ontology.org/term/DOID:1993", "evidence": [ { "id": "1993", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1993" } ], "weight": 0.0 }, { "disease_id": "DOID:2043", "name": "hepatitis B", "description": "A viral hepatitis that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus (Orthohepadnavirus hominoidei), which is transmitted_by sexual contact, blood transfusions, or fomites like needles or syringes. The infection has_symptom fever, fatigue, loss of appetite, nausea, vomiting, abdominal pain, clay-colored bowel movements, joint pain, and jaundice.", "url": "https://disease-ontology.org/term/DOID:2043", "evidence": [ { "id": "2043", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2043" } ], "weight": 0.0 }, { "disease_id": "DOID:219", "name": "colon cancer", "description": "A colorectal cancer that is located_in the colon.", "url": "https://disease-ontology.org/term/DOID:219", "evidence": [ { "id": "219", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:219" } ], "weight": 0.0 }, { "disease_id": "DOID:234", "name": "colon adenocarcinoma", "description": "A colon carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:234", "evidence": [ { "id": "234", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:234" } ], "weight": 0.0 }, { "disease_id": "DOID:2527", "name": "nephrosis", "description": "A proteinuria that is characterized by the leaking of blood protein into the urine, swelling or edema, and degenerative lesions without inflammation.", "url": "https://disease-ontology.org/term/DOID:2527", "evidence": [ { "id": "2527", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2527" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:2957", "name": "pulmonary tuberculosis", "description": "A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis.", "url": "https://disease-ontology.org/term/DOID:2957", "evidence": [ { "id": "2957", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2957" } ], "weight": 0.0 }, { "disease_id": "DOID:3021", "name": "acute kidney failure", "description": "", "url": "https://disease-ontology.org/term/DOID:3021", "evidence": [ { "id": "3021", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3021" } ], "weight": 0.0 }, { "disease_id": "DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:3459", "name": "breast carcinoma", "description": "A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.", "url": "https://disease-ontology.org/term/DOID:3459", "evidence": [ { "id": "3459", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3459" } ], "weight": 0.0 }, { "disease_id": "DOID:3713", "name": "ovary adenocarcinoma", "description": "An ovarian carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:3713", "evidence": [ { "id": "3713", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3713" } ], "weight": 0.0 }, { "disease_id": "DOID:3748", "name": "esophagus squamous cell carcinoma", "description": "An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus.", "url": "https://disease-ontology.org/term/DOID:3748", "evidence": [ { "id": "3748", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3748" } ], "weight": 0.0 }, { "disease_id": "DOID:3905", "name": "lung carcinoma", "description": "A lung cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the lungs and has_symptom cough and has_symptom chest discomfort or pain and has_symptom weight loss and has_symptom hemoptysis.", "url": "https://disease-ontology.org/term/DOID:3905", "evidence": [ { "id": "3905", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3905" } ], "weight": 0.0 }, { "disease_id": "DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.", "url": "https://disease-ontology.org/term/DOID:3908", "evidence": [ { "id": "3908", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ], "weight": 0.0 }, { "disease_id": "DOID:3910", "name": "lung adenocarcinoma", "description": "A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:3910", "evidence": [ { "id": "3910", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3910" } ], "weight": 0.0 }, { "disease_id": "DOID:4810", "name": "cerebrotendinous xanthomatosis", "description": "A xanthomatosis that is characterized by a deficiency in the production of the bile acid, chenodeoxycholic acid that has_material_basis_in homozygous or compound heterozygous mutation in the CYP27A1 gene, which encodes sterol 27-hydroxylase, on chromosome 2q35.", "url": "https://disease-ontology.org/term/DOID:4810", "evidence": [ { "id": "4810", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4810" } ], "weight": 0.0 }, { "disease_id": "DOID:4914", "name": "esophagus adenocarcinoma", "description": "An esophageal carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:4914", "evidence": [ { "id": "4914", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4914" } ], "weight": 0.0 }, { "disease_id": "DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus.", "url": "https://disease-ontology.org/term/DOID:5041", "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ], "weight": 0.0 }, { "disease_id": "DOID:5409", "name": "lung small cell carcinoma", "description": "A lung carcinoma that has_material_basis_in primitive-appearing cells that are smaller than normal cells and is located_in the 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"DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum.", "url": "https://disease-ontology.org/term/DOID:9256", "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ], "weight": 0.0 }, { "disease_id": "DOID:9744", "name": "type 1 diabetes mellitus", "description": "A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production.", "url": "https://disease-ontology.org/term/DOID:9744", "evidence": [ { "id": "9744", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9744" } ], "weight": 0.0 }, { "disease_id": "DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a 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"https://www.ebi.ac.uk/QuickGO/term/GO:0004497", "evidence": [ { "database": "UniProtKB", "id": "Q9VE01", "url": "https://www.uniprot.org/uniprotkb/Q9VE01" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "id": "GO:0016705", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016705", "evidence": [ { "database": "UniProtKB", "id": "Q9VE01", "url": "https://www.uniprot.org/uniprotkb/Q9VE01" } ], "pmid": "" } ], "cellular_component": [ { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "Q9VE01", "url": "https://www.uniprot.org/uniprotkb/Q9VE01" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VEB4-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VEB4", "url": "https://www.uniprot.org/uniprotkb/Q9VEB4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 560, "chemical_mass": 64830.0, "gene_names": "mTerf5;CG7175;D-MTERF5;Dmel\\CG7175;mTerf5", "protein_name": "Transcription termination factor 5, mitochondrial", "disease": [], "biological_process": [ { "name": "termination of mitochondrial transcription", "id": "GO:0006393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006393", "evidence": [ { "database": "UniProtKB", "id": "Q9VEB4", "url": "https://www.uniprot.org/uniprotkb/Q9VEB4" } ], "pmid": "" }, { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "Q9VEB4", "url": "https://www.uniprot.org/uniprotkb/Q9VEB4" } ], "pmid": "" } ], "cellular_component": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q9VEB4", "url": "https://www.uniprot.org/uniprotkb/Q9VEB4" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q9VEB4", "url": "https://www.uniprot.org/uniprotkb/Q9VEB4" } ], "pmid": "" } ], "molecular_function": [ { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "Q9VEB4", "url": "https://www.uniprot.org/uniprotkb/Q9VEB4" } ], "pmid": "" }, { "name": "transcription regulator inhibitor activity", "id": "GO:0140416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140416", "evidence": [ { "database": "UniProtKB", "id": "Q9VEB4", "url": "https://www.uniprot.org/uniprotkb/Q9VEB4" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VEG3-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VEG3", "url": "https://www.uniprot.org/uniprotkb/Q9VEG3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 121, "chemical_mass": 13633.0, "gene_names": "Dmel\\CG14321;CG14321;Dmel\\CG14321;Dmel_CG14321", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VEG9-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VEG9", "url": "https://www.uniprot.org/uniprotkb/Q9VEG9" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 253, "chemical_mass": 28570.0, "gene_names": "nrm;CG7655;Dmel\\CG7655", "protein_name": "Nurim homolog", "disease": [ { "disease_id": "DOID:0050741", "name": "alcohol dependence", "description": "A substance dependence that is characterized by tolerance, withdrawal symptoms, increasing use, persistent desire to decrease consumption, time spent obtaining or recovering from alcohol caused by a physical and psychological dependence on alcohol.", "url": "https://disease-ontology.org/term/DOID:0050741", "evidence": [ { "id": "0050741", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050741" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "Q9VEG9", "url": "https://www.uniprot.org/uniprotkb/Q9VEG9" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "Q9VEG9", "url": "https://www.uniprot.org/uniprotkb/Q9VEG9" } ], "pmid": "" }, { "name": "nuclear inner membrane", "id": "GO:0005637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005637", "evidence": [ { "database": "UniProtKB", "id": "Q9VEG9", "url": "https://www.uniprot.org/uniprotkb/Q9VEG9" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VEM1-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VEM1", "url": "https://www.uniprot.org/uniprotkb/Q9VEM1" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 280, "chemical_mass": 31659.0, "gene_names": "Smug;CG5285_Dm_7300236;CG5285;Dmel\\CG5285;Dmel_CG5285;SMUG1;SMUG;Smug;dmSMUG1;ssUDG", "protein_name": "", "disease": [], "molecular_function": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q9VEM1", "url": "https://www.uniprot.org/uniprotkb/Q9VEM1" } ], "pmid": "" }, { "name": "uracil DNA N-glycosylase activity", "id": "GO:0004844", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004844", "evidence": [ { "database": "UniProtKB", "id": "Q9VEM1", "url": "https://www.uniprot.org/uniprotkb/Q9VEM1" } ], "pmid": "" }, { "name": "single-strand selective uracil DNA N-glycosylase activity", "id": "GO:0017065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017065", "evidence": [ { "database": "UniProtKB", "id": "Q9VEM1", "url": "https://www.uniprot.org/uniprotkb/Q9VEM1" } ], "pmid": "" }, { "name": "oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity", "id": "GO:0000703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000703", "evidence": [ { "database": "UniProtKB", "id": "Q9VEM1", "url": "https://www.uniprot.org/uniprotkb/Q9VEM1" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9VEM1", "url": "https://www.uniprot.org/uniprotkb/Q9VEM1" } ], "pmid": "" } ], "biological_process": [ { "name": "base-excision repair", "id": "GO:0006284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006284", "evidence": [ { "database": "UniProtKB", "id": "Q9VEM1", "url": "https://www.uniprot.org/uniprotkb/Q9VEM1" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VEP1-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VEP1", "url": "https://www.uniprot.org/uniprotkb/Q9VEP1" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 302, "chemical_mass": 33402.0, "gene_names": "Trm7-32;CG5220;Dm 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} ], "biological_process": [ { "name": "tRNA nucleoside ribose methylation", "id": "GO:0002128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002128", "evidence": [ { "database": "UniProtKB", "id": "Q9VEP1", "url": "https://www.uniprot.org/uniprotkb/Q9VEP1" } ], "pmid": "" }, { "name": "tRNA methylation", "id": "GO:0030488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030488", "evidence": [ { "database": "UniProtKB", "id": "Q9VEP1", "url": "https://www.uniprot.org/uniprotkb/Q9VEP1" } ], "pmid": "" }, { "name": "neurogenesis", "id": "GO:0022008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022008", "evidence": [ { "database": "UniProtKB", "id": "Q9VEP1", "url": "https://www.uniprot.org/uniprotkb/Q9VEP1" } ], "pmid": "" }, { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "Q9VEP1", "url": "https://www.uniprot.org/uniprotkb/Q9VEP1" } ], "pmid": "" } ], 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"url": "https://www.uniprot.org/uniprotkb/Q9VF34" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 382, "chemical_mass": 43897.0, "gene_names": "FBpp0082632;AAF55227;CG9593;Dmel\\CG9593;Dmel_CG9593;FBpp0082632", "protein_name": "Fibrinogen C-terminal domain-containing protein", "disease": [ { "disease_id": "DOID:0040094", "name": "autoimmune glomerulonephritis", "description": "An autoimmune disease of urogenital tract that is located_in the renal glomerulus.", "url": "https://disease-ontology.org/term/DOID:0040094", "evidence": [ { "id": "0040094", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0040094" } ], "weight": 0.0 }, { "disease_id": "DOID:0051061", "name": "stroke", "description": "A cerebrovascular disease that is characterized by disruption of blood flow to the brain resulting in damage to brain cells due to a lack of oxygen.", "url": 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"disease_id": "DOID:0080207", "name": "congenital anomalies of the kidney and urinary tract 2", "description": "A congenital anomalies of the kidney and urinary tract that has_material_basis_in heterozygous mutation in the TBX18 gene on chromosome 6q14.", "url": "https://disease-ontology.org/term/DOID:0080207", "evidence": [ { "id": "0080207", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080207" } ], "weight": 0.0 }, { "disease_id": "DOID:0080547", "name": "metabolic dysfunction-associated steatohepatitis", "description": "A metabolic dysfunction-associated steatotic liver disease characterized by the presence of inflammation with hepatocyte injury such as ballooning, with or without fibrosis.", "url": "https://disease-ontology.org/term/DOID:0080547", "evidence": [ { "id": "0080547", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080547" } ], "weight": 0.0 }, { "disease_id": "DOID:0090114", "name": "Sorsby's fundus dystrophy", "description": "A hereditary retinal dystrophy that is characterized by loss of central vision as a result of macular disease by the fourth to fifth decade and peripheral visual loss in late life, and that has_material_basis_in autosomal dominant inheritance of heterozygous mutation in the TIMP metallopeptidase inhibitor 3 (TIMP3) gene on chromosome 22q12.", "url": "https://disease-ontology.org/term/DOID:0090114", "evidence": [ { "id": "0090114", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0090114" } ], "weight": 0.0 }, { "disease_id": "DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate.", "url": "https://disease-ontology.org/term/DOID:10283", "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ], "weight": 0.0 }, { "disease_id": "DOID:10588", "name": "adrenoleukodystrophy", "description": "A leukodystrophy that disrupts the breakdown of very-long-chain fatty acids resulting in progressive brain damage, failure of the adrenal glands and eventually death.", "url": "https://disease-ontology.org/term/DOID:10588", "evidence": [ { "id": "10588", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10588" } ], "weight": 0.0 }, { "disease_id": "DOID:10591", "name": "pre-eclampsia", "description": "A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy.", "url": "https://disease-ontology.org/term/DOID:10591", "evidence": [ { "id": "10591", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10591" } ], "weight": 0.0 }, { "disease_id": "DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.", "url": "https://disease-ontology.org/term/DOID:10652", "evidence": [ { "id": "10652", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ], "weight": 0.0 }, { "disease_id": "DOID:1073", "name": "renal hypertension", "description": "", "url": "https://disease-ontology.org/term/DOID:1073", "evidence": [ { "id": "1073", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1073" } ], "weight": 0.0 }, { "disease_id": "DOID:10762", "name": "portal hypertension", "description": "", "url": "https://disease-ontology.org/term/DOID:10762", "evidence": [ { "id": "10762", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10762" } ], "weight": 0.0 }, { "disease_id": "DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries.", "url": "https://disease-ontology.org/term/DOID:10763", "evidence": [ { "id": "10763", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ], "weight": 0.0 }, { "disease_id": "DOID:10808", "name": "gastric ulcer", "description": "", "url": "https://disease-ontology.org/term/DOID:10808", "evidence": [ { "id": "10808", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10808" } ], "weight": 0.0 }, { "disease_id": "DOID:10941", "name": "intracranial aneurysm", "description": "", "url": "https://disease-ontology.org/term/DOID:10941", "evidence": [ { "id": "10941", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10941" } ], "weight": 0.0 }, { "disease_id": "DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder.", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ], "weight": 0.0 }, { "disease_id": "DOID:114", "name": "heart disease", "description": "A cardiovascular system disease that involves the heart.", "url": "https://disease-ontology.org/term/DOID:114", "evidence": [ { "id": "114", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:114" } ], "weight": 0.0 }, { "disease_id": "DOID:11446", "name": "sciatic neuropathy", "description": "", "url": "https://disease-ontology.org/term/DOID:11446", "evidence": [ { "id": "11446", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11446" } ], "weight": 0.0 }, { "disease_id": "DOID:11723", "name": "Duchenne muscular dystrophy", "description": "A muscular dystrophy that has_material_basis_in X-linked mutations in the DMD gene found on the X chromosome. It is characterized by rapidly progressing muscle weakness and muscle atrophy initially involving the lower extremities and eventually affecting the whole body. It affects males whereas females can be carriers. The symptoms start before the age of six and may appear at infancy.", "url": "https://disease-ontology.org/term/DOID:11723", "evidence": [ { "id": "11723", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11723" } ], "weight": 0.0 }, { "disease_id": "DOID:11984", "name": "hypertrophic cardiomyopathy", "description": "An intrinsic cardiomyopathy that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause.", "url": "https://disease-ontology.org/term/DOID:11984", "evidence": [ { "id": "11984", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11984" } ], "weight": 0.0 }, { "disease_id": "DOID:12858", "name": "Huntington's disease", "description": "A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities.", "url": "https://disease-ontology.org/term/DOID:12858", "evidence": [ { "id": "12858", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12858" } ], "weight": 0.0 }, { "disease_id": "DOID:12930", "name": "dilated cardiomyopathy", "description": "An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently.", "url": "https://disease-ontology.org/term/DOID:12930", "evidence": [ { "id": "12930", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12930" } ], "weight": 0.0 }, { "disease_id": "DOID:13099", "name": "Moyamoya disease", "description": "A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. Blood flow is blocked by the constriction and also by blood clots.", "url": "https://disease-ontology.org/term/DOID:13099", "evidence": [ { "id": "13099", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13099" } ], "weight": 0.0 }, { "disease_id": "DOID:13378", "name": "Kawasaki disease", "description": "A lymphadenitis characterized by swelling of cervical lymph nodes in infants and young children and inflammation of medium-sized blood vessels and that symptoms of fever, congestion of ocular conjunctivae, reddening of lips, reddening of oral cavity, protuberance of tongue papillae and edema of extremities.", "url": "https://disease-ontology.org/term/DOID:13378", "evidence": [ { "id": "13378", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13378" } ], "weight": 0.0 }, { "disease_id": "DOID:13580", "name": "cholestasis", "description": "A bile duct disease that is characterized by where bile cannot flow from the liver to the duodenum.", "url": "https://disease-ontology.org/term/DOID:13580", "evidence": [ { "id": "13580", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13580" } ], "weight": 0.0 }, { "disease_id": "DOID:1380", "name": "endometrial cancer", "description": "A uterine cancer that is located_in tissues lining the uterus.", "url": "https://disease-ontology.org/term/DOID:1380", "evidence": [ { "id": "1380", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1380" } ], "weight": 0.0 }, { "disease_id": "DOID:14004", "name": "thoracic aortic aneurysm", "description": "An aortic aneurysm that is located_in the thoracic aorta.", "url": "https://disease-ontology.org/term/DOID:14004", "evidence": [ { "id": "14004", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14004" } ], "weight": 0.0 }, { "disease_id": "DOID:14250", "name": "Down syndrome", "description": "A chromosomal duplication syndrome that is characterized by flat-looking facial features and weak muscle tone (hypotonia) in infancy and is caused by trisomy of all or a critical portion of chromosome 21 and is associated with intellectual disability.", "url": "https://disease-ontology.org/term/DOID:14250", "evidence": [ { "id": "14250", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14250" } ], "weight": 0.0 }, { "disease_id": "DOID:14323", "name": "Marfan syndrome", "description": "A connective tissue disease that is characterized by tall stature, elongated extremities, mitral valve prolapse, aortic dilatation, aortic dissection, and subluxation of the lens.", "url": "https://disease-ontology.org/term/DOID:14323", "evidence": [ { "id": "14323", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14323" } ], "weight": 0.0 }, { "disease_id": "DOID:1485", "name": "cystic fibrosis", "description": "A syndrome that is characterized by the buildup of thick, sticky mucus that can damage many organs.", "url": "https://disease-ontology.org/term/DOID:1485", "evidence": [ { "id": "1485", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1485" } ], "weight": 0.0 }, { "disease_id": "DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland.", "url": "https://disease-ontology.org/term/DOID:1612", "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ], "weight": 0.0 }, { "disease_id": "DOID:178", "name": "vascular disease", "description": "A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart.", "url": "https://disease-ontology.org/term/DOID:178", "evidence": [ { "id": "178", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:178" } ], "weight": 0.0 }, { "disease_id": "DOID:2006", "name": "preretinal fibrosis", "description": "", "url": "https://disease-ontology.org/term/DOID:2006", "evidence": [ { "id": "2006", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2006" } ], "weight": 0.0 }, { "disease_id": "DOID:2154", "name": "nephroblastoma", "description": "A kidney cancer that affects the kidneys and typically occuring in children.", "url": "https://disease-ontology.org/term/DOID:2154", "evidence": [ { "id": "2154", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2154" } ], "weight": 0.0 }, { "disease_id": "DOID:2378", "name": "relapsing-remitting multiple sclerosis", "description": "A multiple sclerosis that is characterized by relapse (attacks of symptom flare-ups) followed by remission (periods of recovery). Symptoms may vary from mild to severe, and relapses and remissions may last for days or months. More than 80 percent of people who have MS begin with relapsing-remitting cycles.", "url": "https://disease-ontology.org/term/DOID:2378", "evidence": [ { "id": "2378", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2378" } ], "weight": 0.0 }, { "disease_id": "DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary.", "url": "https://disease-ontology.org/term/DOID:2394", "evidence": [ { "id": "2394", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2394" } ], "weight": 0.0 }, { "disease_id": "DOID:2671", "name": "transitional cell carcinoma", "description": "A carcinoma that derives_from transitional epithelial cells.", "url": "https://disease-ontology.org/term/DOID:2671", "evidence": [ { "id": "2671", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2671" } ], "weight": 0.0 }, { "disease_id": "DOID:2871", "name": "endometrial carcinoma", "description": "A endometrial cancer that is located_in the tissue lining the uterus.", "url": "https://disease-ontology.org/term/DOID:2871", "evidence": [ { "id": "2871", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2871" } ], "weight": 0.0 }, { "disease_id": "DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:3459", "name": "breast carcinoma", "description": "A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.", "url": "https://disease-ontology.org/term/DOID:3459", "evidence": [ { "id": "3459", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3459" } ], "weight": 0.0 }, { "disease_id": "DOID:3594", "name": "choriocarcinoma", "description": "A placenta cancer that has_material_basis_in trophoblastic cells.", "url": "https://disease-ontology.org/term/DOID:3594", "evidence": [ { "id": "3594", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3594" } ], "weight": 0.0 }, { "disease_id": "DOID:3744", "name": "cervical squamous cell carcinoma", "description": "A cervix carcinoma that has_material_basis_in squamous cells of the cervix.", "url": "https://disease-ontology.org/term/DOID:3744", "evidence": [ { "id": "3744", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3744" } ], "weight": 0.0 }, { "disease_id": "DOID:3770", "name": "pulmonary fibrosis", "description": "An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation. It can be caused by inhaling hazardous chemicals, certain diseases, medication and genetics or unknown causes.", "url": "https://disease-ontology.org/term/DOID:3770", "evidence": [ { "id": "3770", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3770" } ], "weight": 0.0 }, { "disease_id": "DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.", "url": "https://disease-ontology.org/term/DOID:3908", "evidence": [ { "id": "3908", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ], "weight": 0.0 }, { "disease_id": "DOID:3910", "name": "lung adenocarcinoma", "description": "A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:3910", "evidence": [ { "id": "3910", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3910" } ], "weight": 0.0 }, { "disease_id": "DOID:4001", "name": "ovarian carcinoma", "description": "An ovarian cancer that has_material_basis_in epithelial tissue and is located_in the ovary.", "url": "https://disease-ontology.org/term/DOID:4001", "evidence": [ { "id": "4001", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4001" } ], "weight": 0.0 }, { "disease_id": "DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix.", "url": "https://disease-ontology.org/term/DOID:4362", "evidence": [ { "id": "4362", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4362" } ], "weight": 0.0 }, { "disease_id": "DOID:4450", "name": "renal cell carcinoma", "description": "A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney.", "url": "https://disease-ontology.org/term/DOID:4450", "evidence": [ { "id": "4450", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4450" } ], "weight": 0.0 }, { "disease_id": "DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.", "url": "https://disease-ontology.org/term/DOID:6000", "evidence": [ { "id": "6000", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ], "weight": 0.0 }, { "disease_id": "DOID:7693", "name": "abdominal aortic aneurysm", "description": "An aortic aneurysm that is located_in the abdominal aorta.", "url": "https://disease-ontology.org/term/DOID:7693", "evidence": [ { "id": "7693", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:7693" } ], "weight": 0.0 }, { "disease_id": "DOID:8634", "name": "prostate carcinoma in situ", "description": "An in situ carcinoma that is located_in the prostate.", "url": "https://disease-ontology.org/term/DOID:8634", "evidence": [ { "id": "8634", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8634" } ], "weight": 0.0 }, { "disease_id": "DOID:90", "name": "degenerative disc disease", "description": "A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc.", "url": "https://disease-ontology.org/term/DOID:90", "evidence": [ { "id": "90", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:90" } ], "weight": 0.0 }, { "disease_id": "DOID:9351", "name": "diabetes mellitus", "description": "A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.", "url": "https://disease-ontology.org/term/DOID:9351", "evidence": [ { "id": "9351", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9351" } ], "weight": 0.0 }, { "disease_id": "DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.", "url": "https://disease-ontology.org/term/DOID:9352", "evidence": [ { "id": "9352", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ], "weight": 0.0 }, { "disease_id": "DOID:9744", "name": "type 1 diabetes mellitus", "description": "A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production.", "url": "https://disease-ontology.org/term/DOID:9744", "evidence": [ { "id": "9744", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9744" } ], "weight": 0.0 }, { "disease_id": "DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.", "url": "https://disease-ontology.org/term/DOID:9970", "evidence": [ { "id": "9970", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9970" } ], "weight": 0.0 } ], "biological_process": [ { "name": "negative regulation of membrane protein ectodomain proteolysis", "id": "GO:0051045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051045", "evidence": [ { "database": "UniProtKB", "id": "Q9VH14", "url": "https://www.uniprot.org/uniprotkb/Q9VH14" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "Q9VH14", "url": "https://www.uniprot.org/uniprotkb/Q9VH14" } ], "pmid": "" }, { "name": "oogenesis", "id": "GO:0048477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048477", "evidence": [ { "database": "UniProtKB", "id": "Q9VH14", "url": "https://www.uniprot.org/uniprotkb/Q9VH14" } ], "pmid": "" }, { "name": "basement membrane organization", "id": "GO:0071711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071711", "evidence": [ { "database": "UniProtKB", "id": "Q9VH14", "url": "https://www.uniprot.org/uniprotkb/Q9VH14" } ], "pmid": "" }, { "name": "delamination", "id": "GO:0060232", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060232", "evidence": [ { "database": "UniProtKB", "id": "Q9VH14", "url": "https://www.uniprot.org/uniprotkb/Q9VH14" } ], "pmid": "" }, { "name": "tracheal pit formation in open tracheal system", "id": "GO:0035202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035202", "evidence": [ { "database": "UniProtKB", "id": "Q9VH14", "url": 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"https://www.uniprot.org/uniprotkb/Q9VH14" } ], "pmid": "" } ], "molecular_function": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q9VH14", "url": "https://www.uniprot.org/uniprotkb/Q9VH14" } ], "pmid": "" }, { "name": "metalloendopeptidase inhibitor activity", "id": "GO:0008191", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008191", "evidence": [ { "database": "UniProtKB", "id": "Q9VH14", "url": "https://www.uniprot.org/uniprotkb/Q9VH14" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VH19-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VH19", "url": "https://www.uniprot.org/uniprotkb/Q9VH19" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], 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"" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VI25-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VI25", "url": "https://www.uniprot.org/uniprotkb/Q9VI25" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 723, "chemical_mass": 81629.0, "gene_names": "Neurochondrin;CG2330;Dmel\\CG2330;NCDN;Neurochondrin", "protein_name": "Neurochondrin homolog", "disease": [ { "disease_id": "DOID:5419", "name": "schizophrenia", "description": "A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness.", "url": "https://disease-ontology.org/term/DOID:5419", "evidence": [ { "id": "5419", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5419" } ], "weight": 0.0 } ], "cellular_component": [ { "name": 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"name": "male germline ring canal", "id": "GO:0035323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035323", "evidence": [ { "database": "UniProtKB", "id": "Q9VIP0", "url": "https://www.uniprot.org/uniprotkb/Q9VIP0" } ], "pmid": "" }, { "name": "female germline ring canal", "id": "GO:0035324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035324", "evidence": [ { "database": "UniProtKB", "id": "Q9VIP0", "url": "https://www.uniprot.org/uniprotkb/Q9VIP0" } ], "pmid": "" }, { "name": "fusome", "id": "GO:0045169", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045169", "evidence": [ { "database": "UniProtKB", "id": "Q9VIP0", "url": "https://www.uniprot.org/uniprotkb/Q9VIP0" } ], "pmid": "" } ], "molecular_function": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "Q9VIP0", "url": "https://www.uniprot.org/uniprotkb/Q9VIP0" } ], "pmid": "" } ], "binding_glycans": [], 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} ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VIU7-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VIU7", "url": "https://www.uniprot.org/uniprotkb/Q9VIU7" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 241, "chemical_mass": 27002.0, "gene_names": "Dpm1;CG10166;DPM1;Dmel\\CG10166;Dol-P-ManTase;Dpm1;dDPM", "protein_name": "Dolichol-phosphate mannosyltransferase subunit 1", "disease": [ { "disease_id": "DOID:0050570", "name": "congenital disorder of glycosylation type I", "description": "A congenital disorder of glycosylation characterized by under-glycosylated serum glycoproteins.", "url": "https://disease-ontology.org/term/DOID:0050570", "evidence": [ { "id": "0050570", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050570" } ], 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"species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VLA2", "url": "https://www.uniprot.org/uniprotkb/Q9VLA2" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 606, "chemical_mass": 65674.0, "gene_names": "gcm2;CG3858;Dmel\\CG3858;FBgn0019809;GCM-2;Gcm2;dGCM2;gcm2", "protein_name": "Transcription factor glial cells missing 2", "disease": [ { "disease_id": "DOID:0061151", "name": "familial isolated hypoparathyroidism 2", "description": "A familial isolated hypoparathyroidism that has_material_basis_in homozygous mutation in the glial cells missing transcription factor-2 GCM2 gene on chromosome 6p24. 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"name": "regulation of alternative mRNA splicing, via spliceosome", "id": "GO:0000381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000381", "evidence": [ { "database": "UniProtKB", "id": "Q9VLP7", "url": "https://www.uniprot.org/uniprotkb/Q9VLP7" } ], "pmid": "" }, { "name": "female sex determination", "id": "GO:0030237", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030237", "evidence": [ { "database": "UniProtKB", "id": "Q9VLP7", "url": "https://www.uniprot.org/uniprotkb/Q9VLP7" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VLR9-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VLR9", "url": "https://www.uniprot.org/uniprotkb/Q9VLR9" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 370, "chemical_mass": 43319.0, "gene_names": 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[], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VLT1-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VLT1", "url": "https://www.uniprot.org/uniprotkb/Q9VLT1" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 1684, "chemical_mass": 186993.0, "gene_names": "mon2;CG14276;CG31756;CG8683;Dmel\\CG8683;Dmel_CG8683;Mon2;mon2;noan", "protein_name": "Protein MON2 homolog", "disease": [], "cellular_component": [ { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "Q9VLT1", "url": "https://www.uniprot.org/uniprotkb/Q9VLT1" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q9VLT1", "url": 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"Q9VN25-1", "start_pos": "908", "end_pos": "908", "site_lbl": "Ser908", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "UniProtKB", "id": "Q9VN25", "url": "https://www.uniprot.org/uniprotkb/Q9VN25" }, { "database": "PubMed", "id": "18327897", "url": "https://glygen.org/publication/PubMed/18327897" }, { "database": "iPTMnet", "id": "Q9VN25", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9VN25" } ] } ] } ], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VN97-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VN97", "url": "https://www.uniprot.org/uniprotkb/Q9VN97" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 224, "chemical_mass": 24166.0, "gene_names": "Tim17a2;BcDNA:RH03914;CG14666;Dmel\\CG14666;Tim17a2", "protein_name": 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"" }, { "name": "sensory perception of smell", "id": "GO:0007608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007608", "evidence": [ { "database": "UniProtKB", "id": "Q9VNB3", "url": "https://www.uniprot.org/uniprotkb/Q9VNB3" } ], "pmid": "" }, { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "Q9VNB3", "url": "https://www.uniprot.org/uniprotkb/Q9VNB3" } ], "pmid": "" } ], "cellular_component": [ { "name": "cation channel complex", "id": "GO:0034703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034703", "evidence": [ { "database": "UniProtKB", "id": "Q9VNB3", "url": "https://www.uniprot.org/uniprotkb/Q9VNB3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9VNB3", "url": 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"url": "https://www.uniprot.org/uniprotkb/Q9VQ89" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VQE8-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VQE8", "url": "https://www.uniprot.org/uniprotkb/Q9VQE8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 305, "chemical_mass": 35183.0, "gene_names": "Trf5;CG15398;Dmel\\CG15398;Dmel_CG15398;Trf5;trf5", "protein_name": "", "disease": [], "molecular_function": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q9VQE8", "url": "https://www.uniprot.org/uniprotkb/Q9VQE8" } ], "pmid": "" }, { "name": "RNA polymerase II general transcription initiation factor activity", "id": "GO:0016251", "url": 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"Tdp1;CG8825;CG8826;Dmel\\CG8825;Gkt;Glaikit;TDP1;Tdp1;anon-23Db;c22;gkt", "protein_name": "Tyrosyl-DNA phosphodiesterase 1", "disease": [ { "disease_id": "DOID:0090115", "name": "spinocerebellar ataxia with axonal neuropathy 1", "description": "A nervous system disease characterized by autosomal recessive inheritance of spinocerebellar ataxia and peripheral neuropathy that has_material_basis_in homozygosity for a mutation in the TDP1 gene on chromosome 14q32.11.", "url": "https://disease-ontology.org/term/DOID:0090115", "evidence": [ { "id": "0090115", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0090115" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9VQM4", "url": "https://www.uniprot.org/uniprotkb/Q9VQM4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9VQM4", "url": "https://www.uniprot.org/uniprotkb/Q9VQM4" } ], "pmid": "" } ], "biological_process": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "Q9VQM4", "url": "https://www.uniprot.org/uniprotkb/Q9VQM4" } ], "pmid": "" }, { "name": "central nervous system development", "id": "GO:0007417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007417", "evidence": [ { "database": "UniProtKB", "id": "Q9VQM4", "url": "https://www.uniprot.org/uniprotkb/Q9VQM4" } ], "pmid": "" }, { "name": "establishment or maintenance of epithelial cell apical/basal polarity", "id": "GO:0045197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045197", "evidence": [ { "database": "UniProtKB", "id": "Q9VQM4", "url": "https://www.uniprot.org/uniprotkb/Q9VQM4" } ], "pmid": "" } ], "molecular_function": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q9VQM4", "url": "https://www.uniprot.org/uniprotkb/Q9VQM4" } ], "pmid": "" }, { "name": "double-stranded DNA binding", "id": "GO:0003690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690", "evidence": [ { "database": "UniProtKB", "id": "Q9VQM4", "url": "https://www.uniprot.org/uniprotkb/Q9VQM4" } ], "pmid": "" }, { "name": "exonuclease activity", "id": "GO:0004527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004527", "evidence": [ { "database": "UniProtKB", "id": "Q9VQM4", "url": "https://www.uniprot.org/uniprotkb/Q9VQM4" } ], "pmid": "" }, { "name": "single-stranded DNA binding", "id": "GO:0003697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003697", "evidence": [ { "database": "UniProtKB", "id": "Q9VQM4", "url": "https://www.uniprot.org/uniprotkb/Q9VQM4" } ], "pmid": "" }, { "name": "3'-tyrosyl-DNA phosphodiesterase activity", "id": "GO:0017005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017005", "evidence": [ { "database": "UniProtKB", "id": "Q9VQM4", "url": "https://www.uniprot.org/uniprotkb/Q9VQM4" } ], "pmid": "" }, { "name": "5'-tyrosyl-DNA phosphodiesterase activity", "id": "GO:0070260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070260", "evidence": [ { "database": "UniProtKB", "id": "Q9VQM4", "url": "https://www.uniprot.org/uniprotkb/Q9VQM4" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VQP9-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VQP9", "url": "https://www.uniprot.org/uniprotkb/Q9VQP9" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 149, "chemical_mass": 16823.0, "gene_names": "Ostc;BcDNA:AT03617;CG9662;Dmel\\CG9662", "protein_name": "Oligosaccharyltransferase complex subunit C", "disease": [], "molecular_function": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "Q9VQP9", "url": "https://www.uniprot.org/uniprotkb/Q9VQP9" } ], "pmid": "" } ], "cellular_component": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q9VQP9", "url": "https://www.uniprot.org/uniprotkb/Q9VQP9" } ], "pmid": "" }, { "name": "oligosaccharyltransferase complex", "id": "GO:0008250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008250", "evidence": [ { "database": "UniProtKB", "id": "Q9VQP9", "url": "https://www.uniprot.org/uniprotkb/Q9VQP9" } ], "pmid": "" }, { "name": "oligosaccharyltransferase complex A", "id": "GO:0160226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160226", "evidence": [ { "database": "UniProtKB", "id": "Q9VQP9", "url": "https://www.uniprot.org/uniprotkb/Q9VQP9" } ], "pmid": "" } ], "biological_process": [ { "name": "protein N-linked glycosylation", "id": "GO:0006487", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006487", "evidence": [ { "database": "UniProtKB", "id": "Q9VQP9", "url": "https://www.uniprot.org/uniprotkb/Q9VQP9" } ], "pmid": "" }, { "name": "protein co-translational transfer of dolichol-linked oligosaccharide", "id": "GO:0180058", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0180058", "evidence": [ { "database": "UniProtKB", "id": "Q9VQP9", "url": "https://www.uniprot.org/uniprotkb/Q9VQP9" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VQS5-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VQS5", "url": "https://www.uniprot.org/uniprotkb/Q9VQS5" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 405, "chemical_mass": 47173.0, "gene_names": "IFT57;CG8853;CHE-13;Che-13;Dmel\\CG8853;Hippi;IFT55;IFT57;che-13", "protein_name": "Intraflagellar transport protein 57 homolog", "disease": [ { "disease_id": "DOID:0060340", "name": "ciliopathy", "description": "A syndrome associated with mutations encoding defective proteins, which result in either abnormal function formation or function of cilia.", "url": "https://disease-ontology.org/term/DOID:0060340", "evidence": [ { "id": "0060340", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060340" } ], "weight": 0.0 }, { "disease_id": "DOID:0060961", "name": "orofaciodigital syndrome XVIII", "description": "An orofaciodigital syndrome that is characterized by short stature, brachymesophalangy, pre- and postaxial polysyndactyly, and stocky femoral necks, as well as oral anomalies and dysmorphic facial features that has_material_basis_in homozygous mutation in the IFT57 gene on chromosome 3q13.", "url": "https://disease-ontology.org/term/DOID:0060961", "evidence": [ { "id": "0060961", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060961" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q9VQS5", "url": "https://www.uniprot.org/uniprotkb/Q9VQS5" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "Q9VQS5", "url": "https://www.uniprot.org/uniprotkb/Q9VQS5" } ], "pmid": "" }, { "name": "microtubule organizing center", "id": "GO:0005815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005815", "evidence": [ { "database": "UniProtKB", "id": "Q9VQS5", "url": "https://www.uniprot.org/uniprotkb/Q9VQS5" } ], "pmid": "" }, { 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apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "Q9VQS5", "url": "https://www.uniprot.org/uniprotkb/Q9VQS5" } ], "pmid": "" }, { "name": "non-motile cilium assembly", "id": "GO:1905515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905515", "evidence": [ { "database": "UniProtKB", "id": "Q9VQS5", "url": "https://www.uniprot.org/uniprotkb/Q9VQS5" } ], "pmid": "" }, { "name": "intraciliary transport", "id": "GO:0042073", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042073", "evidence": [ { "database": "UniProtKB", "id": "Q9VQS5", "url": "https://www.uniprot.org/uniprotkb/Q9VQS5" } ], "pmid": "" }, { "name": "intraciliary retrograde transport", "id": "GO:0035721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035721", "evidence": [ { "database": "UniProtKB", "id": "Q9VQS5", "url": "https://www.uniprot.org/uniprotkb/Q9VQS5" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], 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"Elp3;CG15433;D-elp3;Dmel/ELP3;Dmel\\CG15433;Dmel\\ELP3;ELP3;Elp3;HAT;dmHAG408;elp-3;elp3", "protein_name": "Elongator complex protein 3", "disease": [ { "disease_id": "DOID:11589", "name": "familial dysautonomia", "description": "A hereditary sensory and autonomic neuropathy characterized by progressive degeneration of sensory and autonomic neurons with congenital or neonatal onset resulting in impaired pain and temperature perception and profound dysautonomia that has_material_basis_in homozygous or compound heterozygous mutation in the ELP1 gene on chromosome 9q31. Common signs and symptoms include gastrointestinal dysfunction with vomiting crises, recurrent aspiration pneumonia, altered sensitivity to pain and temperature, extreme blood pressure variability with postural hypotension, hypotonia, decreased or absent deep tendon reflexes, decreased taste and absence of fungiform papillae of the tongue, alacrima, and early or sudden death.", "url": "https://disease-ontology.org/term/DOID:11589", "evidence": [ { "id": "11589", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11589" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "protein-lysine-acetyltransferase activity", "id": "GO:0061733", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061733", "evidence": [ { "database": "UniProtKB", "id": "Q9VQZ6", "url": "https://www.uniprot.org/uniprotkb/Q9VQZ6" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q9VQZ6", "url": "https://www.uniprot.org/uniprotkb/Q9VQZ6" } ], "pmid": "" }, { "name": "4 iron, 4 sulfur cluster binding", "id": "GO:0051539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051539", "evidence": [ { "database": "UniProtKB", "id": "Q9VQZ6", "url": "https://www.uniprot.org/uniprotkb/Q9VQZ6" } ], "pmid": "" }, { "name": "tRNA binding", "id": "GO:0000049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", "evidence": [ { "database": "UniProtKB", "id": "Q9VQZ6", "url": "https://www.uniprot.org/uniprotkb/Q9VQZ6" } ], "pmid": "" }, { "name": "acetyltransferase activity", "id": "GO:0016407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016407", "evidence": [ { "database": "UniProtKB", "id": "Q9VQZ6", "url": "https://www.uniprot.org/uniprotkb/Q9VQZ6" } ], "pmid": "" }, { "name": "tRNA uridine(34) acetyltransferase activity", "id": "GO:0106261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106261", "evidence": [ { "database": "UniProtKB", "id": "Q9VQZ6", "url": 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"GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q9VRL2", "url": "https://www.uniprot.org/uniprotkb/Q9VRL2" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "Q9VRL2", "url": "https://www.uniprot.org/uniprotkb/Q9VRL2" } ], "pmid": "" }, { "name": "vesicle fusion", "id": "GO:0006906", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006906", "evidence": [ { "database": "UniProtKB", "id": "Q9VRL2", "url": "https://www.uniprot.org/uniprotkb/Q9VRL2" } ], "pmid": "" }, { "name": "lumen formation, open tracheal system", "id": "GO:0035149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035149", "evidence": [ { "database": "UniProtKB", "id": "Q9VRL2", "url": "https://www.uniprot.org/uniprotkb/Q9VRL2" } ], "pmid": "" } ], "molecular_function": [ { "name": "SNARE binding", "id": "GO:0000149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000149", "evidence": [ { "database": "UniProtKB", "id": "Q9VRL2", "url": "https://www.uniprot.org/uniprotkb/Q9VRL2" } ], "pmid": "" }, { "name": "SNAP receptor activity", "id": "GO:0005484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005484", "evidence": [ { "database": "UniProtKB", "id": "Q9VRL2", "url": "https://www.uniprot.org/uniprotkb/Q9VRL2" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VRL3-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VRL3", "url": "https://www.uniprot.org/uniprotkb/Q9VRL3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 138, "chemical_mass": 15936.0, "gene_names": "Pfdn4;BcDNA:SD11994;CG10635;Dmel\\CG10635;Pfdn4;pfdn4", "protein_name": "Probable prefoldin subunit 4", "disease": [], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9VRL3", "url": "https://www.uniprot.org/uniprotkb/Q9VRL3" } ], "pmid": "" }, { "name": "prefoldin complex", "id": "GO:0016272", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016272", "evidence": [ { "database": "UniProtKB", "id": "Q9VRL3", "url": "https://www.uniprot.org/uniprotkb/Q9VRL3" } ], "pmid": "" } ], "molecular_function": [ { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "Q9VRL3", "url": "https://www.uniprot.org/uniprotkb/Q9VRL3" } ], "pmid": "" } ], "biological_process": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "Q9VRL3", "url": "https://www.uniprot.org/uniprotkb/Q9VRL3" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VRN5-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VRN5", "url": "https://www.uniprot.org/uniprotkb/Q9VRN5" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 195, "chemical_mass": 21594.0, "gene_names": "lin-28;BcDNA:RE05342;CG17334;Dmel\\CG17334;EP(3)0915;LIN-28;LIN28B;Lin-28;Lin28;lin-28;lin28", "protein_name": "Protein lin-28 homolog", "disease": [ { "disease_id": "DOID:2154", "name": "nephroblastoma", "description": "A kidney cancer that affects the kidneys and typically occuring in children.", "url": "https://disease-ontology.org/term/DOID:2154", "evidence": [ { "id": "2154", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2154" } ], "weight": 0.0 }, { "disease_id": "DOID:769", "name": "neuroblastoma", "description": "An autonomic nervous system neoplasm that derives_from immature nerve cells.", "url": "https://disease-ontology.org/term/DOID:769", "evidence": [ { "id": "769", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:769" } ], "weight": 0.0 } ], "biological_process": [ { "name": "post-embryonic digestive tract morphogenesis", "id": "GO:0048621", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048621", "evidence": [ { "database": "UniProtKB", "id": "Q9VRN5", "url": "https://www.uniprot.org/uniprotkb/Q9VRN5" } ], "pmid": "" }, { "name": "positive regulation of stem cell proliferation", "id": "GO:2000648", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000648", "evidence": [ { "database": "UniProtKB", "id": "Q9VRN5", "url": "https://www.uniprot.org/uniprotkb/Q9VRN5" } ], "pmid": "" }, { "name": "post-transcriptional regulation of gene expression", "id": "GO:0010608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010608", 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"https://www.ebi.ac.uk/QuickGO/term/GO:0070935", "evidence": [ { "database": "UniProtKB", "id": "Q9VRN5", "url": "https://www.uniprot.org/uniprotkb/Q9VRN5" } ], "pmid": "" }, { "name": "oogenesis", "id": "GO:0048477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048477", "evidence": [ { "database": "UniProtKB", "id": "Q9VRN5", "url": "https://www.uniprot.org/uniprotkb/Q9VRN5" } ], "pmid": "" }, { "name": "negative regulation of pre-miRNA processing", "id": "GO:2000632", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000632", "evidence": [ { "database": "UniProtKB", "id": "Q9VRN5", "url": "https://www.uniprot.org/uniprotkb/Q9VRN5" } ], "pmid": "" }, { "name": "symmetric stem cell division", "id": "GO:0098724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098724", "evidence": [ { "database": "UniProtKB", "id": "Q9VRN5", "url": "https://www.uniprot.org/uniprotkb/Q9VRN5" } ], "pmid": "" }, { "name": "germ-line stem-cell niche homeostasis", "id": "GO:0060250", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9VRN5", "url": "https://www.uniprot.org/uniprotkb/Q9VRN5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9VRN5", "url": "https://www.uniprot.org/uniprotkb/Q9VRN5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q9VRN5", "url": "https://www.uniprot.org/uniprotkb/Q9VRN5" } ], "pmid": "" }, { "name": "cytoplasmic stress granule", "id": "GO:0010494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010494", "evidence": [ { "database": "UniProtKB", "id": "Q9VRN5", "url": "https://www.uniprot.org/uniprotkb/Q9VRN5" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VRP8-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VRP8", "url": "https://www.uniprot.org/uniprotkb/Q9VRP8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 324, "chemical_mass": 37333.0, "gene_names": "Cralbp;CG10546;CRALBP;Cralbp;Dmel\\CG10546;Dmel_CG10546", "protein_name": "", "disease": [ { "disease_id": "DOID:0050683", "name": "Bothnia retinal dystrophy", "description": "A fundus dystrophy that is characterized by early onset of night blindness and decreased visual acuity that progresses to blindness in early adulthood, has_material_basis_in mutation in RLBP1 gene.", "url": "https://disease-ontology.org/term/DOID:0050683", "evidence": [ { "id": "0050683", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050683" } ], "weight": 0.0 }, { "disease_id": "DOID:0111015", "name": "Newfoundland cone-rod dystrophy", "description": "A cone-rod dystrophy that has_material_basis_in homozygous or compound heterozygous mutation in the RLBP1 gene on chromosome 15q26.", "url": "https://disease-ontology.org/term/DOID:0111015", "evidence": [ { "id": "0111015", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111015" } ], "weight": 0.0 }, { "disease_id": "DOID:10584", "name": "retinitis pigmentosa", "description": "A retinal degeneration characterized by the gradual deterioration of the photoreceptors or the retinal pigment epithelium of the retina leading to progressive sight loss.", "url": "https://disease-ontology.org/term/DOID:10584", "evidence": [ { "id": "10584", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10584" } ], "weight": 0.0 }, { "disease_id": "DOID:11105", "name": "fundus albipunctatus", "description": "A fundus dystrophy that is characterized by discrete uniform white dots over the entire fundus with greatest density in the midperiphery and no 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"id": "GO:0016485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016485", "evidence": [ { "database": "UniProtKB", "id": "Q9VRS5", "url": "https://www.uniprot.org/uniprotkb/Q9VRS5" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VRT5-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VRT5", "url": "https://www.uniprot.org/uniprotkb/Q9VRT5" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 436, "chemical_mass": 49202.0, "gene_names": "Dmel\\CG6602;CG6602;Dmel\\CG6602;Dmel_CG6602", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VRX2-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", 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"evidence": [ { "database": "UniProtKB", "id": "Q9VRX2", "url": "https://www.uniprot.org/uniprotkb/Q9VRX2" } ], "pmid": "" }, { "name": "protein-membrane adaptor activity", "id": "GO:0043495", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043495", "evidence": [ { "database": "UniProtKB", "id": "Q9VRX2", "url": "https://www.uniprot.org/uniprotkb/Q9VRX2" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "Q9VRX2-1", "start_pos": "78", "end_pos": "78", "site_lbl": "Thr78", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 78, "start_aa": "Thr", "end_pos": 78, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr78", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ] } ], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VRX3-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VRX3", "url": "https://www.uniprot.org/uniprotkb/Q9VRX3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 462, "chemical_mass": 50729.0, "gene_names": "betaTub65B;CG32396;CG8339;CT42364;Dmel\\CG32396;Tub2B;Tubb4b;betaTub65B", "protein_name": "beta-Tubulin at 65B", "disease": [], "biological_process": [ { "name": "mitotic cell cycle", "id": "GO:0000278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", "evidence": [ { "database": "UniProtKB", "id": "Q9VRX3", "url": "https://www.uniprot.org/uniprotkb/Q9VRX3" } ], "pmid": "" }, { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q9VRX3", "url": "https://www.uniprot.org/uniprotkb/Q9VRX3" } ], "pmid": "" } ], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9VRX3", "url": "https://www.uniprot.org/uniprotkb/Q9VRX3" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "Q9VRX3", "url": "https://www.uniprot.org/uniprotkb/Q9VRX3" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VS19-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VS19", "url": "https://www.uniprot.org/uniprotkb/Q9VS19" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 605, "chemical_mass": 66390.0, "gene_names": "BBS1;BBS1;CG14825;Dmel\\CG14825;Dmel_CG14825", "protein_name": "", "disease": [ { "disease_id": "DOID:0110123", "name": "Bardet-Biedl syndrome 1", "description": "A Bardet-Biedl syndrome that has_material_basis_in homozygous mutation in the BBS1 gene on chromosome 11q13.", "url": "https://disease-ontology.org/term/DOID:0110123", "evidence": [ { "id": "0110123", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110123" } ], "weight": 0.0 }, { "disease_id": "DOID:1935", "name": "Bardet-Biedl syndrome", "description": "A syndrome that results from mutations in multiple BBS genes affecting cellular cilia structure or function (ciliopathy) resulting in variable presentation and characterized principally by obesity, retinitis pigmentosa,vision loss, polydactyly, mental retardation, hypogonadism, and renal failure in some cases.", 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"https://www.uniprot.org/uniprotkb/Q9VS19" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VS46-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VS46", "url": "https://www.uniprot.org/uniprotkb/Q9VS46" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 724, "chemical_mass": 83535.0, "gene_names": "Rint1;CG8605;Dmel\\CG8605;Rint-1;Rint1;Tip20;rint1", "protein_name": "RINT1-like protein", "disease": [ { "disease_id": "DOID:0080716", "name": "infantile liver failure syndrome", "description": "A syndrome that is characterized by acute liver failure, that occurs in the first year of life, which manifests with failure to thrive, hypotonia, moderate global developmental delay, seizures, abnormal liver function tests, microcytic anemia and elevated serum lactate.", "url": "https://disease-ontology.org/term/DOID:0080716", "evidence": [ { "id": "0080716", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080716" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "Dsl1/NZR complex", "id": "GO:0070939", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070939", "evidence": [ { "database": "UniProtKB", "id": "Q9VS46", "url": "https://www.uniprot.org/uniprotkb/Q9VS46" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q9VS46", "url": "https://www.uniprot.org/uniprotkb/Q9VS46" } ], "pmid": "" } ], "biological_process": [ { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "Q9VS46", "url": "https://www.uniprot.org/uniprotkb/Q9VS46" } ], "pmid": "" }, { "name": "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "id": "GO:0006890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006890", "evidence": [ { "database": "UniProtKB", "id": "Q9VS46", "url": "https://www.uniprot.org/uniprotkb/Q9VS46" } ], "pmid": "" }, { "name": "cleavage furrow ingression", "id": "GO:0036090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036090", "evidence": [ { "database": "UniProtKB", "id": "Q9VS46", "url": "https://www.uniprot.org/uniprotkb/Q9VS46" } ], "pmid": "" }, { "name": "Golgi organization", "id": "GO:0007030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007030", "evidence": [ { "database": "UniProtKB", "id": "Q9VS46", "url": "https://www.uniprot.org/uniprotkb/Q9VS46" } ], "pmid": "" }, { "name": "Golgi vesicle transport", "id": "GO:0048193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048193", "evidence": [ { "database": "UniProtKB", "id": "Q9VS46", "url": "https://www.uniprot.org/uniprotkb/Q9VS46" } ], "pmid": "" }, { "name": "male meiosis cytokinesis", "id": "GO:0007112", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007112", "evidence": [ { "database": "UniProtKB", "id": "Q9VS46", "url": "https://www.uniprot.org/uniprotkb/Q9VS46" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VS51-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VS51", "url": "https://www.uniprot.org/uniprotkb/Q9VS51" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 546, "chemical_mass": 61031.0, "gene_names": "Cln7;CG8596;CLN7;Cln7;Dmel\\CG8596;Dmel_CG8596;cln7", "protein_name": "", "disease": [ { "disease_id": "DOID:0110722", "name": "neuronal ceroid lipofuscinosis 7", "description": "A neuronal ceroid lipofuscinosis that is characterized by late-infantile onset of symptoms (seizures or 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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061964", "evidence": [ { "database": "UniProtKB", "id": "Q9VT51", "url": "https://www.uniprot.org/uniprotkb/Q9VT51" } ], "pmid": "" } ], "molecular_function": [ { "name": "insulin receptor binding", "id": "GO:0005158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005158", "evidence": [ { "database": "UniProtKB", "id": "Q9VT51", "url": "https://www.uniprot.org/uniprotkb/Q9VT51" } ], "pmid": "" }, { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "Q9VT51", "url": "https://www.uniprot.org/uniprotkb/Q9VT51" } ], "pmid": "" }, { "name": "growth factor activity", "id": "GO:0008083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008083", "evidence": [ { "database": "UniProtKB", "id": "Q9VT51", "url": "https://www.uniprot.org/uniprotkb/Q9VT51" } ], "pmid": "" }, { "name": "receptor ligand activity", "id": "GO:0048018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048018", "evidence": [ { "database": "UniProtKB", "id": "Q9VT51", "url": "https://www.uniprot.org/uniprotkb/Q9VT51" } ], "pmid": "" } ], "cellular_component": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q9VT51", "url": "https://www.uniprot.org/uniprotkb/Q9VT51" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q9VT51", "url": "https://www.uniprot.org/uniprotkb/Q9VT51" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VT52-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VT52", "url": "https://www.uniprot.org/uniprotkb/Q9VT52" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 120, "chemical_mass": 13708.0, "gene_names": "Ilp3;CG14167;DILP 3;DILP-3;DILP3;DILPs;DILP;Dilp 3;Dilp-3;Dilp1-5;Dilp3;Dilp;Dmel\\CG14167;ILP3;ILPs;IlP3;Ilp-3;Ilp3;Ilp;dILP-3;dILP3;dILp3;dIlp3;dilp 3;dilp-3;dilp3;dilp;dipl3;dlp3;dlp;ilp3", "protein_name": "Insulin-like peptide 3", "disease": [], "biological_process": [ { "name": "female mating behavior", "id": "GO:0060180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060180", "evidence": [ { "database": "UniProtKB", "id": "Q9VT52", "url": "https://www.uniprot.org/uniprotkb/Q9VT52" } ], "pmid": "" }, { "name": "sleep", "id": "GO:0030431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030431", "evidence": [ { "database": "UniProtKB", "id": "Q9VT52", "url": "https://www.uniprot.org/uniprotkb/Q9VT52" } ], "pmid": "" }, { "name": "insulin receptor signaling pathway", "id": "GO:0008286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008286", "evidence": [ { "database": "UniProtKB", "id": "Q9VT52", "url": "https://www.uniprot.org/uniprotkb/Q9VT52" } ], "pmid": "" }, { "name": "response to carbohydrate", "id": "GO:0009743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009743", "evidence": [ { "database": "UniProtKB", "id": "Q9VT52", "url": "https://www.uniprot.org/uniprotkb/Q9VT52" } ], "pmid": "" }, { "name": "locomotor rhythm", "id": "GO:0045475", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045475", "evidence": [ { "database": "UniProtKB", "id": "Q9VT52", "url": "https://www.uniprot.org/uniprotkb/Q9VT52" } ], "pmid": "" }, { "name": "negative regulation of entry into reproductive diapause", "id": "GO:0061964", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061964", "evidence": [ { "database": "UniProtKB", "id": "Q9VT52", "url": "https://www.uniprot.org/uniprotkb/Q9VT52" } ], "pmid": "" } ], "molecular_function": [ { "name": "insulin receptor binding", "id": "GO:0005158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005158", "evidence": [ { "database": "UniProtKB", "id": "Q9VT52", "url": "https://www.uniprot.org/uniprotkb/Q9VT52" } ], "pmid": "" }, { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "Q9VT52", "url": "https://www.uniprot.org/uniprotkb/Q9VT52" } ], "pmid": "" } ], "cellular_component": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q9VT52", "url": "https://www.uniprot.org/uniprotkb/Q9VT52" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q9VT52", "url": "https://www.uniprot.org/uniprotkb/Q9VT52" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VT53-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VT53", "url": "https://www.uniprot.org/uniprotkb/Q9VT53" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 134, "chemical_mass": 15140.0, "gene_names": "Ilp4;A;BcDNA:RE27042;CG6736;DILP 4;DILP-4;DILP4;DILPs;DILP;Dilp 4;Dilp1-5;Dilp4;Dilp;Dirlp;Dmel\\CG6736;ILP4;ILPs;Ilp-4;Ilp4;Ilp;Mes3;anon-EST:CLB3;dILP4;dIlp4;dilp-4;dilp4;dilp;dlp;ilp4;mes3", "protein_name": "Insulin-like peptide 4", "disease": [ { "disease_id": "DOID:11383", "name": "cryptorchidism", "description": "", "url": "https://disease-ontology.org/term/DOID:11383", "evidence": [ { "id": "11383", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11383" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "insulin receptor binding", "id": "GO:0005158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005158", "evidence": [ { "database": "UniProtKB", "id": "Q9VT53", "url": "https://www.uniprot.org/uniprotkb/Q9VT53" } ], "pmid": "" }, { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "Q9VT53", "url": "https://www.uniprot.org/uniprotkb/Q9VT53" } ], "pmid": "" } ], "cellular_component": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q9VT53", "url": "https://www.uniprot.org/uniprotkb/Q9VT53" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q9VT53", "url": "https://www.uniprot.org/uniprotkb/Q9VT53" } ], "pmid": "" } ], "biological_process": [ { "name": "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway", "id": "GO:0007193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007193", "evidence": [ { "database": "UniProtKB", "id": "Q9VT53", "url": "https://www.uniprot.org/uniprotkb/Q9VT53" } ], "pmid": "" }, { "name": "insulin receptor signaling pathway", "id": "GO:0008286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008286", "evidence": [ { "database": "UniProtKB", "id": "Q9VT53", "url": "https://www.uniprot.org/uniprotkb/Q9VT53" } ], "pmid": "" }, { "name": "larval feeding behavior", "id": "GO:0030536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030536", "evidence": [ { "database": "UniProtKB", "id": "Q9VT53", "url": "https://www.uniprot.org/uniprotkb/Q9VT53" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VT92-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VT92", "url": "https://www.uniprot.org/uniprotkb/Q9VT92" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 391, "chemical_mass": 44475.0, "gene_names": "Or67d;67d;CG14157;DmOr67d;DmelOr67d;Dmel\\CG14157;OR67d;Or67d;or67d", "protein_name": "Odorant receptor 67d", "disease": [], "cellular_component": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9VT92", "url": "https://www.uniprot.org/uniprotkb/Q9VT92" } ], "pmid": "" }, { "name": "dendrite membrane", "id": "GO:0032590", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032590", "evidence": [ { "database": "UniProtKB", "id": "Q9VT92", "url": "https://www.uniprot.org/uniprotkb/Q9VT92" } ], "pmid": "" }, { "name": "sensory dendrite", "id": "GO:0071683", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071683", "evidence": [ { "database": "UniProtKB", "id": "Q9VT92", "url": "https://www.uniprot.org/uniprotkb/Q9VT92" } ], "pmid": "" } ], "biological_process": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q9VT92", "url": "https://www.uniprot.org/uniprotkb/Q9VT92" } ], "pmid": "" }, { "name": "sensory perception of smell", "id": "GO:0007608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007608", "evidence": [ { "database": "UniProtKB", "id": "Q9VT92", "url": "https://www.uniprot.org/uniprotkb/Q9VT92" } ], "pmid": "" }, { "name": "response to pheromone", "id": "GO:0019236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019236", "evidence": [ { "database": "UniProtKB", "id": "Q9VT92", "url": "https://www.uniprot.org/uniprotkb/Q9VT92" } ], "pmid": "" }, { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "Q9VT92", "url": "https://www.uniprot.org/uniprotkb/Q9VT92" } ], "pmid": "" }, { "name": "courtship behavior", "id": "GO:0007619", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007619", "evidence": [ { "database": "UniProtKB", "id": "Q9VT92", "url": "https://www.uniprot.org/uniprotkb/Q9VT92" } ], "pmid": "" }, { "name": "detection of pheromone", "id": "GO:0043695", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043695", "evidence": [ { "database": "UniProtKB", "id": "Q9VT92", "url": "https://www.uniprot.org/uniprotkb/Q9VT92" } ], "pmid": "" } ], "molecular_function": [ { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "Q9VT92", "url": "https://www.uniprot.org/uniprotkb/Q9VT92" } ], "pmid": "" }, { "name": "odorant binding", "id": "GO:0005549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005549", "evidence": [ { "database": "UniProtKB", "id": "Q9VT92", "url": "https://www.uniprot.org/uniprotkb/Q9VT92" } ], "pmid": "" }, { "name": "ionotropic olfactory receptor activity", "id": "GO:0170020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0170020", "evidence": [ { "database": "UniProtKB", "id": "Q9VT92", "url": "https://www.uniprot.org/uniprotkb/Q9VT92" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VTH0-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VTH0", "url": "https://www.uniprot.org/uniprotkb/Q9VTH0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 721, "chemical_mass": 82510.0, "gene_names": "Plod;CG6199;Dmel\\CG6199;LH3;Plod;RE-H;anon-EST:ParkEST325;anon-WO0118547.416;dPlod;dplod;plod", "protein_name": "Procollagen-lysine,2-oxoglutarate 5-dioxygenase", "disease": [ { "disease_id": "DOID:0060231", "name": "Bruck syndrome", "description": "A syndrome characterized by a combination of multiple joint contractures and osteogenesis imperfecta.", "url": "https://disease-ontology.org/term/DOID:0060231", "evidence": [ { "id": "0060231", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060231" } ], "weight": 0.0 }, { "disease_id": "DOID:0061197", "name": "BCARD syndrome", "description": "A connective tissue disease characterized by bone abnormalities, including low bone mineral density, scoliosis, contractures of the fingers and other joints, prominent knees, and rare pathologic fractures; cataract and other ocular abnormalities, including high myopia, optically empty vitreous, and risk for retinal detachment; risk of arterial rupture due to vascular aneurysm or dissection; and sensorineural deafness that has_material_basis_in homozygous or compound heterozygous mutation in the PLOD3 gene on chromosome 7q22.", "url": "https://disease-ontology.org/term/DOID:0061197", "evidence": [ { "id": "0061197", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0061197" } ], "weight": 0.0 }, { "disease_id": "DOID:0080734", "name": "Ehlers-Danlos syndrome kyphoscoliotic type 1", "description": "An Ehlers-Danlos syndrome that is characterized by severe muscle hypotonia at birth, generalized joint laxity, scoliosis at birth, and scleral fragility and rupture of the ocular globe and that has_material_basis_in homozygous or compound heterozygous mutation in the gene encoding lysyl hydroxylase (PLOD1) on chromosome 1p36.", "url": "https://disease-ontology.org/term/DOID:0080734", "evidence": [ { "id": "0080734", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080734" } ], "weight": 0.0 }, { "disease_id": "DOID:13359", "name": "Ehlers-Danlos syndrome", "description": "A collagen disease that is characterized by extremely flexible joints, elastic skin, and excessive bruising caused by a heritable defect in collagen synthesis, which leads to marked healing difficulties. EDS has five cardinal signs, which may be present to some degree in all of the subtypes. These five cardinal signs are skin fragility, blood vessel fragility, skin hyperelasticity, joint hypermobility, and characteristic subcutaneous nodules.", "url": "https://disease-ontology.org/term/DOID:13359", "evidence": [ { "id": "13359", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13359" } ], "weight": 0.0 }, { "disease_id": "DOID:1459", "name": "hypothyroidism", "description": "A thyroid gland disease which involves an underproduction of thyroid hormone.", "url": "https://disease-ontology.org/term/DOID:1459", "evidence": [ { "id": "1459", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1459" } ], "weight": 0.0 }, { "disease_id": "DOID:3910", "name": "lung adenocarcinoma", "description": "A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:3910", "evidence": [ { "id": "3910", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3910" } ], "weight": 0.0 }, { "disease_id": "DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.", "url": "https://disease-ontology.org/term/DOID:684", "evidence": [ { "id": "684", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:684" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "Q9VTH0", "url": "https://www.uniprot.org/uniprotkb/Q9VTH0" } ], "pmid": "" }, { "name": "L-ascorbic acid binding", "id": "GO:0031418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031418", "evidence": [ { "database": "UniProtKB", "id": "Q9VTH0", "url": "https://www.uniprot.org/uniprotkb/Q9VTH0" } ], "pmid": "" }, { "name": "procollagen-lysine 5-dioxygenase activity", "id": 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} ], "biological_process": [ { "name": "protein N-linked glycosylation", "id": "GO:0006487", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006487", "evidence": [ { "database": "UniProtKB", "id": "Q9VUH5", "url": "https://www.uniprot.org/uniprotkb/Q9VUH5" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VUI7-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VUI7", "url": "https://www.uniprot.org/uniprotkb/Q9VUI7" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 766, "chemical_mass": 88890.0, "gene_names": "Dmel\\CG3349;CG3349;Dmel\\CG3349;Dmel_CG3349", "protein_name": "", "disease": [], "cellular_component": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": 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"https://www.uniprot.org/uniprotkb/Q9W0S3" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q9W0S3", "url": "https://www.uniprot.org/uniprotkb/Q9W0S3" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "Q9W0S3", "url": "https://www.uniprot.org/uniprotkb/Q9W0S3" } ], "pmid": "" }, { "name": "TIM23 mitochondrial import inner membrane translocase complex", "id": "GO:0005744", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005744", "evidence": [ { "database": "UniProtKB", "id": "Q9W0S3", "url": "https://www.uniprot.org/uniprotkb/Q9W0S3" } ], "pmid": "" } ], "molecular_function": [ { "name": "ribonucleoprotein complex binding", "id": "GO:0043021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043021", "evidence": [ { "database": 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"evidence": [ { "database": "UniProtKB", "id": "Q9W0S3", "url": "https://www.uniprot.org/uniprotkb/Q9W0S3" } ], "pmid": "" }, { "name": "protein import into mitochondrial matrix", "id": "GO:0030150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030150", "evidence": [ { "database": "UniProtKB", "id": "Q9W0S3", "url": "https://www.uniprot.org/uniprotkb/Q9W0S3" } ], "pmid": "" }, { "name": "mitochondrial membrane organization", "id": "GO:0007006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007006", "evidence": [ { "database": "UniProtKB", "id": "Q9W0S3", "url": "https://www.uniprot.org/uniprotkb/Q9W0S3" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9W4T4-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9W4T4", "url": "https://www.uniprot.org/uniprotkb/Q9W4T4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 1209, "chemical_mass": 129413.0, "gene_names": "Pde4;dnc;CG10791;CG10792;CG10797;CG14267;CG14268;CG32498;DNC;Dmel\\CG32498;Dmel_CG32498;Dnc;Dunce PDE;Dunce;EG:140G11.4;EG:96G10.7;EG:BACN05I09.3;EG:BACN5I9.2;PDE4;PDEII;PDE;dnc;fs(1)M42", "protein_name": "3',5'-cyclic-AMP phosphodiesterase, isoform I", "disease": [ { "disease_id": "DOID:0050741", "name": "alcohol dependence", "description": "A substance dependence that is characterized by tolerance, withdrawal symptoms, increasing use, persistent desire to decrease consumption, time spent obtaining or recovering from alcohol caused by a physical and psychological dependence on alcohol.", "url": "https://disease-ontology.org/term/DOID:0050741", "evidence": [ { "id": "0050741", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050741" } ], "weight": 0.0 }, { "disease_id": "DOID:0051061", "name": "stroke", "description": "A cerebrovascular disease that is characterized by disruption of blood flow to the brain resulting in damage to brain cells due to a lack of oxygen.", "url": "https://disease-ontology.org/term/DOID:0051061", "evidence": [ { "id": "0051061", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0051061" } ], "weight": 0.0 }, { "disease_id": "DOID:11077", "name": "brucellosis", "description": "A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. 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The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. 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"memory", "id": "GO:0007613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007613", "evidence": [ { "database": "UniProtKB", "id": "Q9W4T4", "url": "https://www.uniprot.org/uniprotkb/Q9W4T4" } ], "pmid": "" }, { "name": "mating behavior", "id": "GO:0007617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007617", "evidence": [ { "database": "UniProtKB", "id": "Q9W4T4", "url": "https://www.uniprot.org/uniprotkb/Q9W4T4" } ], "pmid": "" }, { "name": "associative learning", "id": "GO:0008306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008306", "evidence": [ { "database": "UniProtKB", "id": "Q9W4T4", "url": "https://www.uniprot.org/uniprotkb/Q9W4T4" } ], "pmid": "" }, { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "Q9W4T4", "url": "https://www.uniprot.org/uniprotkb/Q9W4T4" } ], "pmid": "" }, { "name": "short-term memory", "id": "GO:0007614", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007614", "evidence": [ { "database": "UniProtKB", "id": "Q9W4T4", "url": "https://www.uniprot.org/uniprotkb/Q9W4T4" } ], "pmid": "" }, { "name": "circadian rhythm", "id": "GO:0007623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007623", "evidence": [ { "database": "UniProtKB", "id": "Q9W4T4", "url": "https://www.uniprot.org/uniprotkb/Q9W4T4" } ], "pmid": "" }, { "name": "conditioned taste aversion", "id": "GO:0001661", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001661", "evidence": [ { "database": "UniProtKB", "id": "Q9W4T4", "url": "https://www.uniprot.org/uniprotkb/Q9W4T4" } ], "pmid": "" }, { "name": "olfactory learning", "id": "GO:0008355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008355", "evidence": [ { "database": "UniProtKB", "id": "Q9W4T4", "url": "https://www.uniprot.org/uniprotkb/Q9W4T4" } ], "pmid": "" }, { "name": "axon extension", "id": "GO:0048675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048675", "evidence": [ { "database": "UniProtKB", "id": "Q9W4T4", "url": "https://www.uniprot.org/uniprotkb/Q9W4T4" } ], "pmid": "" }, { "name": "thermosensory behavior", "id": "GO:0040040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0040040", "evidence": [ { "database": "UniProtKB", "id": "Q9W4T4", "url": "https://www.uniprot.org/uniprotkb/Q9W4T4" } ], "pmid": "" }, { "name": "cAMP catabolic process", "id": "GO:0006198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006198", "evidence": [ { "database": "UniProtKB", "id": "Q9W4T4", "url": "https://www.uniprot.org/uniprotkb/Q9W4T4" } ], "pmid": "" }, { "name": "anesthesia-resistant memory", "id": "GO:0007615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007615", "evidence": [ { "database": "UniProtKB", "id": "Q9W4T4", "url": "https://www.uniprot.org/uniprotkb/Q9W4T4" } ], "pmid": "" }, { "name": "courtship behavior", "id": "GO:0007619", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007619", "evidence": [ { "database": "UniProtKB", "id": "Q9W4T4", "url": "https://www.uniprot.org/uniprotkb/Q9W4T4" } ], "pmid": "" }, { "name": "behavioral response to ethanol", "id": "GO:0048149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048149", "evidence": [ { "database": "UniProtKB", "id": "Q9W4T4", "url": "https://www.uniprot.org/uniprotkb/Q9W4T4" } ], "pmid": "" }, { "name": "negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0106072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106072", "evidence": [ { "database": "UniProtKB", "id": "Q9W4T4", "url": "https://www.uniprot.org/uniprotkb/Q9W4T4" } ], "pmid": "" }, { "name": "medium-term memory", "id": "GO:0072375", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072375", "evidence": [ { "database": "UniProtKB", "id": "Q9W4T4", "url": "https://www.uniprot.org/uniprotkb/Q9W4T4" } ], "pmid": "" }, { "name": "negative regulation of cAMP/PKA signal transduction", "id": "GO:0141162", "url": 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[], "sites": [ { "uniprot_canonical_ac": "Q9W4T4-1", "start_pos": "398", "end_pos": "398", "site_lbl": "Thr398", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 398, "start_aa": "Thr", "end_pos": 398, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr398", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ] } ], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VCL4-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VCL4", "url": "https://www.uniprot.org/uniprotkb/Q9VCL4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", 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"A8DYE0", "url": "https://www.uniprot.org/uniprotkb/A8DYE0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 1339, "chemical_mass": 146759.0, "gene_names": "Kank;BEST:GH19041;BcDNA:GH03482;CG10249;Dmel\\CG10249;Dmel_CG10249;Kank;dKank;kank", "protein_name": "", "disease": [ { "disease_id": "DOID:0070554", "name": "palmoplantar keratoderma and woolly hair", "description": "A nonepidermolytic palmoplantar keratoderma characterized by striate palmoplantar keratoderma, sparse and woolly hair, leukonychia, and the absence of cardiomyopathy symptoms or findings on echocardiography and electrocardiogram that has_material_basis_in homozygous mutation in the KANK2 gene on chromosome 19p13.2.", "url": "https://disease-ontology.org/term/DOID:0070554", "evidence": [ { "id": "0070554", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070554" } ], "weight": 0.0 }, { "disease_id": "DOID:0080272", 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Affected individuals have cognitive regression and intellectual disability and that has_material_basis_in heterozygous mutation in the SLC6A1 gene on chromosome 3p25.", "url": "https://disease-ontology.org/term/DOID:0060475", "evidence": [ { "id": "0060475", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060475" } ], "weight": 0.0 }, { "disease_id": "DOID:0060536", "name": "mitochondrial complex I deficiency", "description": "A mitochondrial metabolism disease characterized by a wide range of manifestations including marked and often fatal lactic acidosis, cardiomyopathy, leukoencephalopathy, pure myopathy and hepatopathy with tubulopathy. Among the numerous clinical phenotypes observed are Leigh syndrome, Leber hereditary optic neuropathy and MELAS syndrome. 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has_material_basis_in compound heterozygous mutation in the SLC25A10 gene on chromosome 17q25.3.", "url": "https://disease-ontology.org/term/DOID:0070450", "evidence": [ { "id": "0070450", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070450" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A1Z787", "url": "https://www.uniprot.org/uniprotkb/A1Z787" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A1Z787", "url": "https://www.uniprot.org/uniprotkb/A1Z787" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A1Z787", "url": "https://www.uniprot.org/uniprotkb/A1Z787" } ], "pmid": "" } ], "molecular_function": [ { "name": "phosphate transmembrane transporter activity", "id": "GO:0005315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005315", "evidence": [ { "database": "UniProtKB", "id": "A1Z787", "url": "https://www.uniprot.org/uniprotkb/A1Z787" } ], "pmid": "" }, { "name": "sulfate transmembrane transporter activity", "id": "GO:0015116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015116", "evidence": [ { "database": "UniProtKB", "id": "A1Z787", "url": "https://www.uniprot.org/uniprotkb/A1Z787" } ], "pmid": "" }, { "name": "thiosulfate transmembrane transporter activity", "id": "GO:0015117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015117", "evidence": [ { "database": "UniProtKB", "id": "A1Z787", "url": "https://www.uniprot.org/uniprotkb/A1Z787" } ], "pmid": "" }, { "name": "oxaloacetate transmembrane transporter activity", "id": "GO:0015131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015131", "evidence": [ { "database": "UniProtKB", "id": "A1Z787", "url": "https://www.uniprot.org/uniprotkb/A1Z787" } ], "pmid": "" }, { "name": "succinate transmembrane transporter activity", "id": "GO:0015141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015141", "evidence": [ { "database": "UniProtKB", "id": "A1Z787", "url": "https://www.uniprot.org/uniprotkb/A1Z787" } ], "pmid": "" } ], "biological_process": [ { "name": "sulfate transmembrane transport", "id": "GO:1902358", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902358", "evidence": [ { "database": "UniProtKB", "id": "A1Z787", "url": "https://www.uniprot.org/uniprotkb/A1Z787" } ], "pmid": "" }, { "name": "thiosulfate transport", "id": "GO:0015709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015709", "evidence": [ { "database": "UniProtKB", "id": "A1Z787", "url": "https://www.uniprot.org/uniprotkb/A1Z787" } ], "pmid": "" }, { "name": "oxaloacetate transport", "id": "GO:0015729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015729", "evidence": [ { "database": "UniProtKB", "id": "A1Z787", "url": "https://www.uniprot.org/uniprotkb/A1Z787" } ], "pmid": "" }, { "name": "phosphate ion transmembrane transport", "id": "GO:0035435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035435", "evidence": [ { "database": "UniProtKB", "id": "A1Z787", "url": "https://www.uniprot.org/uniprotkb/A1Z787" } ], "pmid": "" }, { "name": "succinate transmembrane transport", "id": "GO:0071422", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071422", "evidence": [ { "database": "UniProtKB", "id": "A1Z787", "url": "https://www.uniprot.org/uniprotkb/A1Z787" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q2PDM3-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q2PDM3", "url": "https://www.uniprot.org/uniprotkb/Q2PDM3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 2289, "chemical_mass": 256533.0, "gene_names": "Dmel\\CG33978;FBgn0053978;CG33978;Dmel\\CG33978;Dmel_CG33978;FBgn0053978", "protein_name": "DUF4758 domain-containing protein", "disease": [], "molecular_function": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q2PDM3", "url": "https://www.uniprot.org/uniprotkb/Q2PDM3" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "Q2PDM3-1", "start_pos": "67", "end_pos": "67", "site_lbl": "Thr67", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 67, "start_aa": "Thr", "end_pos": 67, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr67", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ] } ], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "O76896-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "O76896", "url": "https://www.uniprot.org/uniprotkb/O76896" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 441, "chemical_mass": 49545.0, "gene_names": "Dmel\\CG4293;EG:65F1.1;154711_at;CG4293;Dmel\\CG4293;Dmel_CG4293;EG:65F1.1", "protein_name": "", "disease": [], "cellular_component": [ { "name": "COPII-coated ER to Golgi transport vesicle", "id": "GO:0030134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030134", "evidence": [ { "database": "UniProtKB", "id": "O76896", "url": "https://www.uniprot.org/uniprotkb/O76896" } ], "pmid": "" }, { "name": "endoplasmic reticulum-Golgi intermediate compartment membrane", "id": "GO:0033116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033116", "evidence": [ { "database": "UniProtKB", "id": "O76896", "url": "https://www.uniprot.org/uniprotkb/O76896" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "O76896", "url": "https://www.uniprot.org/uniprotkb/O76896" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O76896", "url": "https://www.uniprot.org/uniprotkb/O76896" } ], "pmid": "" } ], "biological_process": [ { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "O76896", "url": "https://www.uniprot.org/uniprotkb/O76896" } ], "pmid": "" }, { "name": "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "id": "GO:0006890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006890", "evidence": [ { "database": "UniProtKB", "id": "O76896", "url": "https://www.uniprot.org/uniprotkb/O76896" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q8IMF4-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8IMF4", "url": "https://www.uniprot.org/uniprotkb/Q8IMF4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 554, "chemical_mass": 63548.0, "gene_names": "Dmel\\CG2201;CG2201;Dmel\\CG2201;Dmel_CG2201", "protein_name": "", "disease": [ { "disease_id": "DOID:0050912", "name": "colon adenoma", "description": "A colonic benign neoplasm that has_material_basis_in epithelial tissue with glandular origin.", "url": "https://disease-ontology.org/term/DOID:0050912", "evidence": [ { "id": "0050912", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050912" } ], "weight": 0.0 }, { "disease_id": "DOID:0110632", "name": "megaconial type congenital muscular dystrophy", "description": "A congenital muscular dystrophy characterized by autosomal recessive inheritance of early-onset muscle wasting and intellectual disability with enlarged mitochondria that are more prevalent towards the periphery of the fibers that has_material_basis_in homozygous or compound heterozygous mutation in the CHKB gene on chromosome 22q13.", "url": "https://disease-ontology.org/term/DOID:0110632", "evidence": [ { "id": "0110632", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110632" } ], "weight": 0.0 }, { "disease_id": "DOID:1059", "name": "intellectual disability", "description": "A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills.", "url": "https://disease-ontology.org/term/DOID:1059", "evidence": [ { "id": "1059", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1059" } ], "weight": 0.0 }, { "disease_id": "DOID:10907", "name": "microcephaly", "description": "A congenital nervous system abnormality that is characterized by a significantly smaller than normal head in infants.", "url": "https://disease-ontology.org/term/DOID:10907", "evidence": [ { "id": "10907", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10907" } ], "weight": 0.0 }, { "disease_id": "DOID:1826", "name": "epilepsy", "description": "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions.", "url": "https://disease-ontology.org/term/DOID:1826", "evidence": [ { "id": "1826", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1826" } ], "weight": 0.0 }, { "disease_id": "DOID:219", "name": "colon cancer", "description": "A colorectal cancer that is located_in the colon.", "url": "https://disease-ontology.org/term/DOID:219", "evidence": [ { "id": "219", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:219" } ], "weight": 0.0 }, { "disease_id": "DOID:224", "name": "transient cerebral ischemia", "description": "A brain ischemia that is characterized by ischemia of brief duration and without resultant tissue death.", "url": "https://disease-ontology.org/term/DOID:224", "evidence": [ { "id": "224", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:224" } ], 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"database": "UniProtKB", "id": "Q8IMF4", "url": "https://www.uniprot.org/uniprotkb/Q8IMF4" } ], "pmid": "" } ], "molecular_function": [ { "name": "choline kinase activity", "id": "GO:0004103", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004103", "evidence": [ { "database": "UniProtKB", "id": "Q8IMF4", "url": "https://www.uniprot.org/uniprotkb/Q8IMF4" } ], "pmid": "" }, { "name": "ethanolamine kinase activity", "id": "GO:0004305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004305", "evidence": [ { "database": "UniProtKB", "id": "Q8IMF4", "url": "https://www.uniprot.org/uniprotkb/Q8IMF4" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q8IPQ2-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8IPQ2", "url": "https://www.uniprot.org/uniprotkb/Q8IPQ2" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 594, "chemical_mass": 65101.0, "gene_names": "CRMP;BcDNA:HL02693;CG1411;CRMP;DHP;Dmel\\CG1411;Dmel_CG1411;EP(3)3238;EP3238;Pyd2;crmp;l(3)83Ba;pyd2", "protein_name": "dihydropyrimidinase", "disease": [ { "disease_id": "DOID:0060565", "name": "Ritscher-Schinzel syndrome", "description": "A syndrome characterized by craniofacial (prominent occiputal and forehead, hypertelorism, ocular coloboma, cleft palate), cerebellar (Dandy-Walker malformation, cerebellar vermis hypoplasia) and cardiac (tetralogy of Fallot, atrial and ventricular septal defects) anomalies.", "url": "https://disease-ontology.org/term/DOID:0060565", "evidence": [ { "id": "0060565", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060565" } ], "weight": 0.0 }, { "disease_id": "DOID:0111629", "name": "dihydropyrimidinase deficiency", "description": "A pyrimidine metabolic disorder characterized by a defect in the degradation of 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{ "disease_id": "DOID:2316", "name": "brain ischemia", "description": "An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand.", "url": "https://disease-ontology.org/term/DOID:2316", "evidence": [ { "id": "2316", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2316" } ], "weight": 0.0 }, { "disease_id": "DOID:653", "name": "purine-pyrimidine metabolic disorder", "description": "An inherited metabolic disorder involving dysfunction of purine and pyrimidine metabolism.", "url": "https://disease-ontology.org/term/DOID:653", "evidence": [ { "id": "653", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:653" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "dihydropyrimidinase activity", "id": "GO:0004157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004157", "evidence": [ { "database": "UniProtKB", "id": "Q8IPQ2", "url": "https://www.uniprot.org/uniprotkb/Q8IPQ2" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q8IPQ2", "url": "https://www.uniprot.org/uniprotkb/Q8IPQ2" } ], "pmid": "" } ], "biological_process": [ { "name": "memory", "id": "GO:0007613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007613", "evidence": [ { "database": "UniProtKB", "id": "Q8IPQ2", "url": "https://www.uniprot.org/uniprotkb/Q8IPQ2" } ], "pmid": "" }, { "name": "Ras protein signal transduction", "id": "GO:0007265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007265", "evidence": [ { "database": "UniProtKB", "id": "Q8IPQ2", "url": "https://www.uniprot.org/uniprotkb/Q8IPQ2" } ], "pmid": "" }, { "name": "centrosome localization", "id": "GO:0051642", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051642", "evidence": [ { "database": "UniProtKB", "id": "Q8IPQ2", "url": "https://www.uniprot.org/uniprotkb/Q8IPQ2" } ], "pmid": "" }, { "name": "'de novo' pyrimidine nucleobase 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Most newborns who develop BPD are born more than 10 weeks before their due dates, weigh less than 2 pounds at birth, and have breathing problems.", "url": "https://disease-ontology.org/term/DOID:11650", "evidence": [ { "id": "11650", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11650" } ], "weight": 0.0 }, { "disease_id": "DOID:13375", "name": "temporal arteritis", "description": "A central nervous system vasculitis that is characterized by inflammation of the lining of arteries, often arteries in the head.", "url": "https://disease-ontology.org/term/DOID:13375", "evidence": [ { "id": "13375", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13375" } ], "weight": 0.0 }, { "disease_id": "DOID:13406", "name": "pulmonary sarcoidosis", "description": "A sarcoidosis that is characterized by noncaseating granulomatous infiltration of the lungs and supporting lymph nodes, bilateral hilar adenopathy, and pulmonary issues, has_symptom shortness of breath, fatigue, wheezing, and chronic cough, and develops_from a type IV hypersensitivity reaction.", "url": "https://disease-ontology.org/term/DOID:13406", "evidence": [ { "id": "13406", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13406" } ], "weight": 0.0 }, { "disease_id": "DOID:1380", "name": "endometrial cancer", "description": "A uterine cancer that is located_in tissues lining the uterus.", "url": "https://disease-ontology.org/term/DOID:1380", "evidence": [ { "id": "1380", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1380" } ], "weight": 0.0 }, { "disease_id": "DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland.", "url": "https://disease-ontology.org/term/DOID:1612", "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ], "weight": 0.0 }, { "disease_id": "DOID:1909", "name": "melanoma", "description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye.", "url": "https://disease-ontology.org/term/DOID:1909", "evidence": [ { "id": "1909", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1909" } ], "weight": 0.0 }, { "disease_id": "DOID:2349", "name": "arteriosclerosis", "description": "An artery disease that is characterized by a thickening and hardening of arterial walls in the arteries.", "url": "https://disease-ontology.org/term/DOID:2349", "evidence": [ { "id": "2349", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2349" } ], "weight": 0.0 }, { "disease_id": "DOID:2378", "name": "relapsing-remitting multiple sclerosis", "description": "A multiple sclerosis that is characterized by relapse (attacks of symptom flare-ups) followed by remission (periods of recovery). Symptoms may vary from mild to severe, and relapses and remissions may last for days or months. More than 80 percent of people who have MS begin with relapsing-remitting cycles.", "url": "https://disease-ontology.org/term/DOID:2378", "evidence": [ { "id": "2378", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2378" } ], "weight": 0.0 }, { "disease_id": "DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary.", "url": "https://disease-ontology.org/term/DOID:2394", "evidence": [ { "id": "2394", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2394" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:3068", "name": "glioblastoma", "description": "A malignant astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes.", "url": "https://disease-ontology.org/term/DOID:3068", "evidence": [ { "id": "3068", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3068" } ], "weight": 0.0 }, { "disease_id": "DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:3371", "name": "chondrosarcoma", "description": "A bone sarcoma that has_material_basis_in cells derived from transformed cells that produce cartilage.", "url": "https://disease-ontology.org/term/DOID:3371", "evidence": [ { "id": "3371", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3371" } ], "weight": 0.0 }, { "disease_id": "DOID:3393", "name": "coronary artery disease", "description": "An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.", "url": "https://disease-ontology.org/term/DOID:3393", "evidence": [ { "id": "3393", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3393" } ], "weight": 0.0 }, { "disease_id": "DOID:3770", "name": "pulmonary fibrosis", "description": "An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation. It can be caused by inhaling hazardous chemicals, certain diseases, medication and genetics or unknown causes.", "url": "https://disease-ontology.org/term/DOID:3770", "evidence": [ { "id": "3770", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3770" } ], "weight": 0.0 }, { "disease_id": "DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.", "url": "https://disease-ontology.org/term/DOID:3908", "evidence": [ { "id": "3908", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ], "weight": 0.0 }, { "disease_id": "DOID:418", "name": "systemic scleroderma", "description": "A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.", "url": "https://disease-ontology.org/term/DOID:418", "evidence": [ { "id": "418", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:418" } ], "weight": 0.0 }, { "disease_id": "DOID:5419", "name": "schizophrenia", "description": "A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness.", "url": "https://disease-ontology.org/term/DOID:5419", "evidence": [ { "id": "5419", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5419" } ], "weight": 0.0 }, { "disease_id": "DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.", "url": "https://disease-ontology.org/term/DOID:5844", "evidence": [ { "id": "5844", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ], "weight": 0.0 }, { "disease_id": "DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.", "url": "https://disease-ontology.org/term/DOID:6000", "evidence": [ { "id": "6000", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ], "weight": 0.0 }, { "disease_id": "DOID:7148", "name": "rheumatoid arthritis", "description": "An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.", "url": "https://disease-ontology.org/term/DOID:7148", "evidence": [ { "id": "7148", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:7148" } ], "weight": 0.0 }, { "disease_id": "DOID:8869", "name": "neuromyelitis optica", "description": "A central nervous system disease characterized by inflammation of the optic nerve (optic neuritis) and inflammation of the spinal cord (myelitis).", "url": "https://disease-ontology.org/term/DOID:8869", "evidence": [ { "id": "8869", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8869" } ], "weight": 0.0 }, { "disease_id": "DOID:9119", "name": "acute myeloid leukemia", "description": "A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.", "url": "https://disease-ontology.org/term/DOID:9119", "evidence": [ { "id": "9119", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9119" } ], "weight": 0.0 }, { "disease_id": "DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.", "url": "https://disease-ontology.org/term/DOID:9352", "evidence": [ { "id": "9352", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ], "weight": 0.0 }, { "disease_id": "DOID:9470", "name": "bacterial meningitis", "description": "A meningitis that has_material_basis_in a bacterial infection.", "url": "https://disease-ontology.org/term/DOID:9470", "evidence": [ { "id": "9470", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9470" } ], "weight": 0.0 }, { "disease_id": "DOID:9538", "name": "multiple myeloma", "description": "A myeloid neoplasm that is located_in the plasma cells in bone marrow.", "url": "https://disease-ontology.org/term/DOID:9538", "evidence": [ { "id": "9538", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9538" } ], "weight": 0.0 }, { "disease_id": "DOID:9744", "name": "type 1 diabetes mellitus", "description": "A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production.", "url": "https://disease-ontology.org/term/DOID:9744", "evidence": [ { "id": "9744", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9744" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q9W303", "url": "https://www.uniprot.org/uniprotkb/Q9W303" } ], "pmid": "" } ], "biological_process": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "Q9W303", "url": "https://www.uniprot.org/uniprotkb/Q9W303" } ], "pmid": "" }, { "name": "wound healing", "id": "GO:0042060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042060", "evidence": [ { "database": "UniProtKB", "id": "Q9W303", "url": "https://www.uniprot.org/uniprotkb/Q9W303" } ], "pmid": "" }, { "name": "chitin catabolic process", "id": "GO:0006032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006032", "evidence": [ { "database": "UniProtKB", "id": "Q9W303", "url": "https://www.uniprot.org/uniprotkb/Q9W303" } ], "pmid": "" }, { "name": "imaginal disc development", "id": "GO:0007444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007444", "evidence": [ { "database": "UniProtKB", "id": "Q9W303", "url": "https://www.uniprot.org/uniprotkb/Q9W303" } ], "pmid": "" }, { "name": "ecdysis, chitin-based cuticle", "id": "GO:0018990", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018990", "evidence": [ { "database": "UniProtKB", "id": "Q9W303", "url": "https://www.uniprot.org/uniprotkb/Q9W303" } ], "pmid": "" }, { "name": "chitin-based cuticle development", "id": "GO:0040003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0040003", "evidence": [ { "database": "UniProtKB", "id": "Q9W303", "url": "https://www.uniprot.org/uniprotkb/Q9W303" } ], "pmid": "" } ], "molecular_function": [ { "name": "chitin binding", "id": "GO:0008061", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008061", "evidence": [ { "database": "UniProtKB", "id": "Q9W303", "url": "https://www.uniprot.org/uniprotkb/Q9W303" } ], "pmid": "" }, { "name": "imaginal disc growth factor receptor binding", "id": "GO:0008084", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008084", "evidence": [ { "database": "UniProtKB", "id": "Q9W303", "url": "https://www.uniprot.org/uniprotkb/Q9W303" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "Q9W303-1", "start_pos": "224", "end_pos": "224", "site_lbl": "Asn224", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 224, "start_aa": "Asn", "end_pos": 224, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn224", "evidence": [ { "id": "Q9W303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9W303#ptm_processing" } ] } ] } ], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9W328-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9W328", "url": "https://www.uniprot.org/uniprotkb/Q9W328" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 313, "chemical_mass": 35347.0, "gene_names": "Lst8;CG3004;Dmel\\CG3004;Gbl;LST8;Lst8;dGbetaL;dLST8;lst8", "protein_name": "Protein LST8 homolog", "disease": [], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9W328", "url": "https://www.uniprot.org/uniprotkb/Q9W328" } ], "pmid": "" }, { "name": "TORC2 complex", "id": "GO:0031932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031932", "evidence": [ { "database": "UniProtKB", "id": "Q9W328", "url": "https://www.uniprot.org/uniprotkb/Q9W328" } ], "pmid": "" } ], "biological_process": [ { "name": "regulation of actin cytoskeleton organization", "id": "GO:0032956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032956", "evidence": [ { "database": "UniProtKB", "id": "Q9W328", "url": "https://www.uniprot.org/uniprotkb/Q9W328" } ], "pmid": "" }, { "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "Q9W328", "url": "https://www.uniprot.org/uniprotkb/Q9W328" } ], "pmid": "" }, { "name": "TOR signaling", "id": "GO:0031929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031929", "evidence": [ { "database": "UniProtKB", "id": "Q9W328", "url": "https://www.uniprot.org/uniprotkb/Q9W328" } ], "pmid": "" }, { "name": "protein localization to nucleus", "id": "GO:0034504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034504", "evidence": [ { "database": "UniProtKB", "id": "Q9W328", "url": "https://www.uniprot.org/uniprotkb/Q9W328" } ], "pmid": "" }, { "name": "positive regulation of cell size", "id": "GO:0045793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045793", "evidence": [ { "database": "UniProtKB", "id": "Q9W328", "url": "https://www.uniprot.org/uniprotkb/Q9W328" } ], "pmid": "" }, { "name": "positive regulation of insulin receptor signaling pathway", "id": "GO:0046628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046628", "evidence": [ { "database": "UniProtKB", "id": "Q9W328", "url": "https://www.uniprot.org/uniprotkb/Q9W328" } ], "pmid": "" }, { "name": "TORC1 signaling", "id": "GO:0038202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038202", "evidence": [ { "database": "UniProtKB", "id": "Q9W328", "url": "https://www.uniprot.org/uniprotkb/Q9W328" } ], "pmid": "" }, { "name": "TORC2 signaling", "id": "GO:0038203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038203", "evidence": [ { "database": "UniProtKB", "id": "Q9W328", "url": "https://www.uniprot.org/uniprotkb/Q9W328" } ], "pmid": "" }, { "name": "positive regulation of transcription by transcription factor localization", "id": "GO:0061586", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061586", "evidence": [ { "database": "UniProtKB", "id": "Q9W328", "url": "https://www.uniprot.org/uniprotkb/Q9W328" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9W349-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9W349", "url": "https://www.uniprot.org/uniprotkb/Q9W349" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 826, "chemical_mass": 84722.0, "gene_names": "lz;CG1689;Dmel\\CG1689;LZ;Lozenge;Lz;amx;fs(1)A1569;fs(1)M69;lz;spe", "protein_name": "Protein lozenge", "disease": [ { "disease_id": "DOID:0050861", "name": "colorectal adenocarcinoma", "description": "A colorectal carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:0050861", "evidence": [ { "id": "0050861", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050861" } ], "weight": 0.0 }, { "disease_id": "DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach.", "url": "https://disease-ontology.org/term/DOID:10534", "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ], "weight": 0.0 }, { "disease_id": "DOID:1380", "name": "endometrial cancer", "description": "A uterine cancer that is located_in tissues lining the uterus.", "url": "https://disease-ontology.org/term/DOID:1380", "evidence": [ { "id": "1380", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1380" } ], "weight": 0.0 }, { "disease_id": "DOID:289", "name": "endometriosis", "description": "A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.", "url": "https://disease-ontology.org/term/DOID:289", "evidence": [ { "id": "289", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:289" } ], "weight": 0.0 }, { "disease_id": "DOID:3033", "name": "colon signet ring adenocarcinoma", "description": "", "url": "https://disease-ontology.org/term/DOID:3033", "evidence": [ { "id": "3033", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3033" } ], "weight": 0.0 }, { "disease_id": "DOID:3525", "name": "middle cerebral artery infarction", "description": "", "url": "https://disease-ontology.org/term/DOID:3525", "evidence": [ { "id": "3525", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3525" } ], "weight": 0.0 }, { "disease_id": "DOID:3748", "name": "esophagus squamous cell carcinoma", "description": "An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus.", 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} ], "pmid": "" } ], "cellular_component": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprotkb/Q9W3C7" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprotkb/Q9W3C7" } ], "pmid": "" } ], "molecular_function": [ { "name": "serine hydrolase activity", "id": "GO:0017171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017171", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": "https://www.uniprot.org/uniprotkb/Q9W3C7" } ], "pmid": "" }, { "name": "palmitoyl-(protein) hydrolase activity", "id": "GO:0008474", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008474", "evidence": [ { "database": "UniProtKB", "id": "Q9W3C7", "url": 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"" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q9W3E2", "url": "https://www.uniprot.org/uniprotkb/Q9W3E2" } ], "pmid": "" }, { "name": "rhabdomere", "id": "GO:0016028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016028", "evidence": [ { "database": "UniProtKB", "id": "Q9W3E2", "url": "https://www.uniprot.org/uniprotkb/Q9W3E2" } ], "pmid": "" } ], "biological_process": [ { "name": "photoreceptor cell maintenance", "id": "GO:0045494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045494", "evidence": [ { "database": "UniProtKB", "id": "Q9W3E2", "url": "https://www.uniprot.org/uniprotkb/Q9W3E2" } ], "pmid": "" }, { "name": "photoreceptor cell differentiation", "id": "GO:0046530", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046530", "evidence": [ { "database": "UniProtKB", "id": "Q9W3E2", "url": "https://www.uniprot.org/uniprotkb/Q9W3E2" } ], "pmid": "" }, { "name": "cellular 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"single-stranded DNA 3'-5' DNA exonuclease activity", "id": "GO:0008310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008310", "evidence": [ { "database": "UniProtKB", "id": "Q9W3M9", "url": "https://www.uniprot.org/uniprotkb/Q9W3M9" } ], "pmid": "" }, { "name": "single-stranded DNA binding", "id": "GO:0003697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003697", "evidence": [ { "database": "UniProtKB", "id": "Q9W3M9", "url": "https://www.uniprot.org/uniprotkb/Q9W3M9" } ], "pmid": "" } ], "cellular_component": [ { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q9W3M9", "url": "https://www.uniprot.org/uniprotkb/Q9W3M9" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9W3N6-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": 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"GO:0016973", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016973", "evidence": [ { "database": "UniProtKB", "id": "Q9XZ06", "url": "https://www.uniprot.org/uniprotkb/Q9XZ06" } ], "pmid": "" }, { "name": "nuclear pore organization", "id": "GO:0006999", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006999", "evidence": [ { "database": "UniProtKB", "id": "Q9XZ06", "url": "https://www.uniprot.org/uniprotkb/Q9XZ06" } ], "pmid": "" }, { "name": "nucleocytoplasmic transport", "id": "GO:0006913", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006913", "evidence": [ { "database": "UniProtKB", "id": "Q9XZ06", "url": "https://www.uniprot.org/uniprotkb/Q9XZ06" } ], "pmid": "" }, { "name": "negative regulation of gene expression, epigenetic", "id": "GO:0045814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045814", "evidence": [ { "database": "UniProtKB", "id": "Q9XZ06", "url": "https://www.uniprot.org/uniprotkb/Q9XZ06" } ], "pmid": "" }, { "name": "regulation of nucleus size", "id": "GO:0097298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097298", "evidence": [ { "database": "UniProtKB", "id": "Q9XZ06", "url": "https://www.uniprot.org/uniprotkb/Q9XZ06" } ], "pmid": "" }, { "name": "protein localization to nuclear inner membrane", "id": "GO:0036228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036228", "evidence": [ { "database": "UniProtKB", "id": "Q9XZ06", "url": "https://www.uniprot.org/uniprotkb/Q9XZ06" } ], "pmid": "" }, { "name": "protein import into nucleus", "id": "GO:0006606", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006606", "evidence": [ { "database": "UniProtKB", "id": "Q9XZ06", "url": "https://www.uniprot.org/uniprotkb/Q9XZ06" } ], "pmid": "" }, { "name": "oocyte karyosome formation", "id": "GO:0030717", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030717", "evidence": [ { "database": "UniProtKB", "id": "Q9XZ06", "url": "https://www.uniprot.org/uniprotkb/Q9XZ06" } ], "pmid": "" }, { "name": "chromosome attachment to the nuclear 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"https://www.ebi.ac.uk/QuickGO/term/GO:0031490", "evidence": [ { "database": "UniProtKB", "id": "Q9XZ06", "url": "https://www.uniprot.org/uniprotkb/Q9XZ06" } ], "pmid": "" }, { "name": "structural constituent of nuclear pore", "id": "GO:0017056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017056", "evidence": [ { "database": "UniProtKB", "id": "Q9XZ06", "url": "https://www.uniprot.org/uniprotkb/Q9XZ06" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9XZF0-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9XZF0", "url": "https://www.uniprot.org/uniprotkb/Q9XZF0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 121, "chemical_mass": 13743.0, "gene_names": "Ype;CG1989;Dmel\\CG1989;YIPPEE;Yippee;Ype;eb;sable;s", "protein_name": "Protein yippee", 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"Q9XZF0", "url": "https://www.uniprot.org/uniprotkb/Q9XZF0" } ], "pmid": "" }, { "name": "chaeta morphogenesis", "id": "GO:0008407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008407", "evidence": [ { "database": "UniProtKB", "id": "Q9XZF0", "url": "https://www.uniprot.org/uniprotkb/Q9XZF0" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9XZT7-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9XZT7", "url": "https://www.uniprot.org/uniprotkb/Q9XZT7" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 146, "chemical_mass": 15784.0, "gene_names": "Taf10b;CG3069;Dmel\\CG3069;TAF10b;TAFII16;TAF[[II]]16;TAF[[II]];TAF;TFIID;Taf10b;Taf10;Taf16;TafII16;dTAF10b;dTAF[[II]]16;dTaf10b;dmTAF10b;dtafII16;taf10b", "protein_name": "Transcription initiation factor 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"biological_process": [ { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "Q9XZT7", "url": "https://www.uniprot.org/uniprotkb/Q9XZT7" } ], "pmid": "" }, { "name": "transcription initiation at RNA polymerase II promoter", "id": "GO:0006367", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006367", "evidence": [ { "database": "UniProtKB", "id": "Q9XZT7", "url": "https://www.uniprot.org/uniprotkb/Q9XZT7" } ], "pmid": "" } ], "molecular_function": [ { "name": "promoter-specific chromatin binding", "id": "GO:1990841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990841", "evidence": [ { "database": "UniProtKB", "id": "Q9XZT7", "url": "https://www.uniprot.org/uniprotkb/Q9XZT7" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9Y106-1", "species": [ { "name": 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"id": "Q9Y106", "url": "https://www.uniprot.org/uniprotkb/Q9Y106" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9Y123-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9Y123", "url": "https://www.uniprot.org/uniprotkb/Q9Y123" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 556, "chemical_mass": 62426.0, "gene_names": "BcDNA:GH08388;CG3149;Dmel\\CG3149", "protein_name": "Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1", "disease": [ { "disease_id": "DOID:0050570", "name": "congenital disorder of glycosylation type I", "description": "A congenital disorder of glycosylation characterized by under-glycosylated serum glycoproteins.", "url": "https://disease-ontology.org/term/DOID:0050570", "evidence": [ { "id": "0050570", "database": "AGR", 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"cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A1Z6N4", "url": "https://www.uniprot.org/uniprotkb/A1Z6N4" } ], "pmid": "" } ], "biological_process": [ { "name": "locomotory behavior", "id": "GO:0007626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007626", "evidence": [ { "database": "UniProtKB", "id": "A1Z6N4", "url": "https://www.uniprot.org/uniprotkb/A1Z6N4" } ], "pmid": "" }, { "name": "behavioral response to cocaine", "id": "GO:0048148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048148", "evidence": [ { "database": "UniProtKB", "id": "A1Z6N4", "url": "https://www.uniprot.org/uniprotkb/A1Z6N4" } ], "pmid": "" }, { "name": "locomotor rhythm", "id": "GO:0045475", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045475", "evidence": [ { "database": "UniProtKB", "id": "A1Z6N4", "url": "https://www.uniprot.org/uniprotkb/A1Z6N4" } ], "pmid": "" }, { "name": "amino acid metabolic process", "id": "GO:0006520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006520", "evidence": [ { "database": "UniProtKB", "id": "A1Z6N4", "url": "https://www.uniprot.org/uniprotkb/A1Z6N4" } ], "pmid": "" }, { "name": "octopamine biosynthetic process", "id": "GO:0006589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006589", "evidence": [ { "database": "UniProtKB", "id": "A1Z6N4", "url": "https://www.uniprot.org/uniprotkb/A1Z6N4" } ], "pmid": "" }, { "name": "carboxylic acid metabolic process", "id": "GO:0019752", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019752", "evidence": [ { "database": "UniProtKB", "id": "A1Z6N4", "url": "https://www.uniprot.org/uniprotkb/A1Z6N4" } ], "pmid": "" }, { "name": "egg-laying behavior", "id": "GO:0018991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018991", "evidence": [ { "database": "UniProtKB", "id": "A1Z6N4", "url": "https://www.uniprot.org/uniprotkb/A1Z6N4" } ], "pmid": "" }, { "name": "tyramine biosynthetic process", "id": "GO:1901695", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901695", "evidence": [ { "database": "UniProtKB", "id": "A1Z6N4", "url": "https://www.uniprot.org/uniprotkb/A1Z6N4" } ], "pmid": "" } ], "molecular_function": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "A1Z6N4", "url": "https://www.uniprot.org/uniprotkb/A1Z6N4" } ], "pmid": "" }, { "name": "carboxy-lyase activity", "id": "GO:0016831", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016831", "evidence": [ { "database": "UniProtKB", "id": "A1Z6N4", "url": "https://www.uniprot.org/uniprotkb/A1Z6N4" } ], "pmid": "" }, { "name": "tyrosine decarboxylase activity", "id": "GO:0004837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004837", "evidence": [ { "database": "UniProtKB", "id": "A1Z6N4", "url": "https://www.uniprot.org/uniprotkb/A1Z6N4" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "A1Z6N5-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1Z6N5", "url": "https://www.uniprot.org/uniprotkb/A1Z6N5" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 440, "chemical_mass": 47578.0, "gene_names": "Dmel\\CG3270;CG3270;Dmel\\CG3270;Dmel_CG3270", "protein_name": "FAD-dependent oxidoreductase domain-containing protein 1", "disease": [ { "disease_id": "DOID:0112085", "name": "nuclear type mitochondrial complex I deficiency 19", "description": "A nuclear type mitochondrial complex I deficiency that has_material_basis_in homozygous or compound heterozygous mutation in the FOXRED1 gene on chromosome 11q24.2.", "url": "https://disease-ontology.org/term/DOID:0112085", "evidence": [ { "id": "0112085", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0112085" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A1Z6N5", "url": "https://www.uniprot.org/uniprotkb/A1Z6N5" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A1Z6N5", "url": "https://www.uniprot.org/uniprotkb/A1Z6N5" } ], "pmid": "" } ], "biological_process": [ { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "A1Z6N5", "url": "https://www.uniprot.org/uniprotkb/A1Z6N5" } ], "pmid": "" } ], "molecular_function": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "A1Z6N5", "url": "https://www.uniprot.org/uniprotkb/A1Z6N5" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "A1Z6R4-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1Z6R4", "url": "https://www.uniprot.org/uniprotkb/A1Z6R4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 403, "chemical_mass": 45362.0, "gene_names": "Spn42Dc;CG9455;Dmel\\CG9455;Dmel_CG9455;Spn42Dc", "protein_name": "", "disease": [ { "disease_id": "DOID:0050831", "name": "familial encephalopathy with neuroserpin inclusion bodies", "description": "A neurodegenerative disease that is characterized by intraneuronal inclusions of mutant neuroserpin resulting in progressive encephalopathy, dementia and seizures and has_material_basis_in a mutation in the SERPINI1 gene inherited in an in autosomal dominant pattern.", "url": "https://disease-ontology.org/term/DOID:0050831", "evidence": [ { "id": "0050831", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050831" } ], "weight": 0.0 }, { "disease_id": "DOID:0070508", "name": "metabolic dysfunction and alcohol associated liver disease", "description": "A steatotic liver disease characterized by at least one of five specified cardiometabolic risk factors and elevated alcohol consumption. This disease is distinguished from MASLD by increased alcohol consumption and from ALD by the evidence of one or more of the specified cardiometabolic risk factors. The five cardiometabolic risk factors are: (1) higher than normal body mass index or waist circumference; (2) higher than normal serum glucose or glycated hemoglobin level, or type 2 diabetes; (3) higher than normal blood pressure or hypertensive treatment; (4) higher than normal plasma triglycerides or lipid lowering treatment; and (5) lower than normal plasma high-density lipoprotein cholesterol.", "url": "https://disease-ontology.org/term/DOID:0070508", "evidence": [ { "id": "0070508", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070508" } ], "weight": 0.0 }, { "disease_id": "DOID:0070555", "name": "Nagashima-type palmoplantar keratosis", "description": "A nonepidermolytic palmoplantar keratoderma characterized by mild, well-demarcated, diffuse erythematous hyperkeratosis that is nonprogressive after the second decade of life which extends onto the dorsal surfaces of the palms and feet and the Achilles tendon area, with a high frequency of hyperhidrosis on the palms and soles and without flexion contractures or constricting bands that has_material_basis_in homozygous or compound heterozygous mutation in the SERPINB7 gene on chromosome 18q21.33.", "url": "https://disease-ontology.org/term/DOID:0070555", "evidence": [ { "id": "0070555", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070555" } ], "weight": 0.0 }, { "disease_id": "DOID:0080322", "name": "polycystic kidney disease", "description": "A cystic kidney disease that is characterized by the growth of fluid-filled cysts in the kidneys that reduces kidney function and may lead to kidney failure.", "url": "https://disease-ontology.org/term/DOID:0080322", "evidence": [ { "id": "0080322", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080322" } ], "weight": 0.0 }, { "disease_id": "DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.", "url": "https://disease-ontology.org/term/DOID:10652", "evidence": [ { "id": "10652", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ], "weight": 0.0 }, { "disease_id": "DOID:10762", "name": "portal hypertension", "description": "", "url": "https://disease-ontology.org/term/DOID:10762", "evidence": [ { "id": "10762", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10762" } ], "weight": 0.0 }, { "disease_id": "DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries.", "url": "https://disease-ontology.org/term/DOID:10763", "evidence": [ { "id": "10763", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ], "weight": 0.0 }, { "disease_id": "DOID:10808", "name": "gastric ulcer", "description": "", "url": "https://disease-ontology.org/term/DOID:10808", "evidence": [ { "id": "10808", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10808" } ], "weight": 0.0 }, { "disease_id": "DOID:10952", "name": "nephritis", "description": "A kidney disease that is characterized by an inflammation of the kidneys.", "url": "https://disease-ontology.org/term/DOID:10952", "evidence": [ { "id": "10952", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10952" } ], "weight": 0.0 }, { "disease_id": "DOID:11049", "name": "meconium aspiration syndrome", "description": "A lung disease that is characterized by a newborn breathing in a mixture of meconium and amniotic fluid into the lungs around the time of delivery.", "url": "https://disease-ontology.org/term/DOID:11049", "evidence": [ { "id": "11049", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11049" } ], "weight": 0.0 }, { "disease_id": "DOID:11394", "name": "adult respiratory distress syndrome", "description": "A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.", "url": "https://disease-ontology.org/term/DOID:11394", "evidence": [ { "id": "11394", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11394" } ], "weight": 0.0 }, { "disease_id": "DOID:11446", "name": "sciatic neuropathy", "description": "", "url": "https://disease-ontology.org/term/DOID:11446", "evidence": [ { "id": "11446", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11446" } ], "weight": 0.0 }, { "disease_id": "DOID:11716", "name": "prediabetes syndrome", "description": "A glucose metabolism disease that is characterized by blood glucose levels are high, but not high enough to be classified as type 2 diabetes.", "url": "https://disease-ontology.org/term/DOID:11716", "evidence": [ { "id": "11716", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11716" } ], "weight": 0.0 }, { "disease_id": "DOID:12236", "name": "primary biliary cholangitis", "description": "A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts.", "url": "https://disease-ontology.org/term/DOID:12236", "evidence": [ { "id": "12236", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12236" } ], "weight": 0.0 }, { "disease_id": "DOID:12930", "name": "dilated cardiomyopathy", "description": "An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently.", "url": "https://disease-ontology.org/term/DOID:12930", "evidence": [ { "id": "12930", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12930" } ], "weight": 0.0 }, { "disease_id": "DOID:13025", "name": "retinopathy of prematurity", "description": "", "url": "https://disease-ontology.org/term/DOID:13025", "evidence": [ { "id": "13025", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13025" } ], "weight": 0.0 }, { "disease_id": "DOID:1312", "name": "focal segmental glomerulosclerosis", "description": "", "url": "https://disease-ontology.org/term/DOID:1312", "evidence": [ { "id": "1312", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1312" } ], "weight": 0.0 }, { "disease_id": "DOID:13141", "name": "uveitis", "description": "An uveal disease is characterized by inflammation of any of the layers of the uvea of the eye, which includes the iris, ciliary body, and choroid.", "url": "https://disease-ontology.org/term/DOID:13141", "evidence": [ { "id": "13141", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13141" } ], "weight": 0.0 }, { "disease_id": "DOID:1875", "name": "impotence", "description": "A sexual dysfunction that is characterized by persistent or recurrent inability to achieve or to maintain an erection during sexual activity.", "url": "https://disease-ontology.org/term/DOID:1875", "evidence": [ { "id": "1875", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1875" } ], "weight": 0.0 }, { "disease_id": "DOID:1936", "name": "atherosclerosis", "description": "An arteriosclerotic cardiovascular disease that is characterized by the build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen. Disease is located within the tunica intima of large and small arteries.", "url": "https://disease-ontology.org/term/DOID:1936", "evidence": [ { "id": "1936", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1936" } ], "weight": 0.0 }, { "disease_id": "DOID:224", "name": "transient cerebral ischemia", "description": "A brain ischemia that is characterized by ischemia of brief duration and without resultant tissue death.", "url": "https://disease-ontology.org/term/DOID:224", "evidence": [ { "id": "224", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:224" } ], "weight": 0.0 }, { "disease_id": "DOID:2450", "name": "central retinal vein occlusion", "description": "", "url": "https://disease-ontology.org/term/DOID:2450", "evidence": [ { "id": "2450", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2450" } ], "weight": 0.0 }, { "disease_id": "DOID:289", "name": "endometriosis", "description": "A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.", "url": "https://disease-ontology.org/term/DOID:289", "evidence": [ { "id": "289", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:289" } ], "weight": 0.0 }, { "disease_id": "DOID:2921", "name": "glomerulonephritis", "description": "A nephritis that causes inflammation of the glomeruli located_in kidney.", "url": "https://disease-ontology.org/term/DOID:2921", "evidence": [ { "id": "2921", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2921" } ], "weight": 0.0 }, { "disease_id": "DOID:2986", "name": "IgA glomerulonephritis", "description": "A glomerulonephritis characterized by build up of IgA antibody in the glomerulus.", "url": "https://disease-ontology.org/term/DOID:2986", "evidence": [ { "id": "2986", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2986" } ], "weight": 0.0 }, { "disease_id": "DOID:3328", "name": "temporal lobe epilepsy", "description": "A focal epilepsy that is characterized by recurrent, unprovoked focal seizures that originate in the temporal lobe of the brain and last about one or two minutes.", "url": "https://disease-ontology.org/term/DOID:3328", "evidence": [ { "id": "3328", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3328" } ], "weight": 0.0 }, { "disease_id": "DOID:3525", "name": "middle cerebral artery infarction", "description": "", "url": "https://disease-ontology.org/term/DOID:3525", "evidence": [ { "id": "3525", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3525" } ], "weight": 0.0 }, { "disease_id": "DOID:3770", "name": "pulmonary fibrosis", "description": "An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation. It can be caused by inhaling hazardous chemicals, certain diseases, medication and genetics or unknown causes.", "url": "https://disease-ontology.org/term/DOID:3770", "evidence": [ { "id": "3770", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3770" } ], "weight": 0.0 }, { "disease_id": "DOID:4448", "name": "macular degeneration", "description": "A retinal degeneration characterized by gradual deterioration of light-sensing cells in the tissues at the back of the eye and has_symptom vision loss.", "url": "https://disease-ontology.org/term/DOID:4448", "evidence": [ { "id": "4448", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4448" } ], "weight": 0.0 }, { "disease_id": "DOID:4780", "name": "anti-basement membrane glomerulonephritis", "description": "A Goodpasture syndrome that is characterized by damage to only kidney capillaries.", "url": "https://disease-ontology.org/term/DOID:4780", "evidence": [ { "id": "4780", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4780" } ], "weight": 0.0 }, { "disease_id": "DOID:5082", "name": "liver cirrhosis", "description": "", "url": "https://disease-ontology.org/term/DOID:5082", "evidence": [ { "id": "5082", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5082" } ], "weight": 0.0 }, { "disease_id": "DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.", "url": "https://disease-ontology.org/term/DOID:5844", "evidence": [ { "id": "5844", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ], "weight": 0.0 }, { "disease_id": "DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.", "url": "https://disease-ontology.org/term/DOID:6000", "evidence": [ { "id": "6000", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ], "weight": 0.0 }, { "disease_id": "DOID:6432", "name": "pulmonary hypertension", "description": "A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries.", "url": "https://disease-ontology.org/term/DOID:6432", "evidence": [ { "id": "6432", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6432" } ], "weight": 0.0 }, { "disease_id": "DOID:8947", "name": "diabetic retinopathy", "description": "", "url": "https://disease-ontology.org/term/DOID:8947", "evidence": [ { "id": "8947", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8947" } ], "weight": 0.0 }, { "disease_id": "DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin 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[], "biological_process": [ { "name": "imaginal disc fusion, thorax closure", "id": "GO:0046529", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046529", "evidence": [ { "database": "UniProtKB", "id": "A1Z6X0", "url": "https://www.uniprot.org/uniprotkb/A1Z6X0" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "A1Z709-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1Z709", "url": "https://www.uniprot.org/uniprotkb/A1Z709" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 1397, "chemical_mass": 151548.0, "gene_names": "Corin;CG2105;Corin;Dmel\\CG2105;Dmel_CG2105;SP75;corin", "protein_name": "", "disease": [ { "disease_id": "DOID:0080326", "name": "familial hypertrophic cardiomyopathy", "description": "A hypertrophic cardiomyopathy that is characterized by 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[], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "A1Z7G9-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1Z7G9", "url": "https://www.uniprot.org/uniprotkb/A1Z7G9" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 382, "chemical_mass": 44424.0, "gene_names": "beta3GalTII;CG8734;Dmel\\CG8734;Dmel_CG8734;GalTII;beta3GalTII;dGAGbeta3GalTII;dbeta3GalTII", "protein_name": "Hexosyltransferase", "disease": [ { "disease_id": "DOID:0050802", "name": "Ehlers-Danlos syndrome spondylodysplastic type 2", "description": "An Ehlers-Danlos syndrome that is characterized by aged appearance, developmental delay, short stature, craniofacial disproportion, generalized osteopenia, defective wound healing, hypermobile joints, hypotonic muscles, and loose but elastic skin and has_material_basis_in compound 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"https://www.uniprot.org/uniprotkb/A1Z7G9" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "A1Z7I5-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1Z7I5", "url": "https://www.uniprot.org/uniprotkb/A1Z7I5" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 451, "chemical_mass": 51938.0, "gene_names": "Dmel\\CG30357;BcDNA:AT27059;CG30357;Dmel\\CG30357;Dmel_CG30357", "protein_name": "BACK domain-containing protein", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "A1Z7J0-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1Z7J0", "url": "https://www.uniprot.org/uniprotkb/A1Z7J0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 329, "chemical_mass": 38055.0, "gene_names": "Dmel\\CG8746;CG8746;Dmel\\CG8746;Dmel_CG8746", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "A1Z7L2-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1Z7L2", "url": "https://www.uniprot.org/uniprotkb/A1Z7L2" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 113, "chemical_mass": 12815.0, "gene_names": "Dmel\\CG13748;CG13748;Dmel\\CG13748;Dmel_CG13748", "protein_name": "BPTI/Kunitz inhibitor domain-containing protein", "disease": [ { "disease_id": "DOID:0060224", "name": "atrial fibrillation", "description": "A heart conduction disease that is characterized by uncoordinated electrical 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"Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 369, "chemical_mass": 41721.0, "gene_names": "Cpr47Ee;CG13222;Cpr47Ee;DmelCpr47Ee;Dmel\\CG13222;Dmel_CG13222", "protein_name": "", "disease": [], "molecular_function": [ { "name": "structural constituent of chitin-based larval cuticle", "id": "GO:0008010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008010", "evidence": [ { "database": "UniProtKB", "id": "A1Z8H6", "url": "https://www.uniprot.org/uniprotkb/A1Z8H6" } ], "pmid": "" } ], "biological_process": [ { "name": "chitin-based cuticle development", "id": "GO:0040003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0040003", "evidence": [ { "database": "UniProtKB", "id": "A1Z8H6", "url": "https://www.uniprot.org/uniprotkb/A1Z8H6" } ], "pmid": "" } ], "cellular_component": [ { "name": "chitin-based extracellular matrix", "id": "GO:0062129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062129", "evidence": [ { "database": 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"id": "A1Z8S6", "url": "https://www.uniprot.org/uniprotkb/A1Z8S6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 1218, "chemical_mass": 138888.0, "gene_names": "pds5;CG17509;Dmel\\CG17509;Dmel_CG17509;PDS5;Pds5;anon-WO0118547.183;dPds5;l(2)k13312;pds5", "protein_name": "", "disease": [ { "disease_id": "DOID:11725", "name": "Cornelia de Lange syndrome", "description": "A syndrome that is characterized by slow growth before and after birth, intellectual disability that is usually severe to profound, skeletal abnormalities involving the arms and hands, and distinctive facial features.", "url": "https://disease-ontology.org/term/DOID:11725", "evidence": [ { "id": "11725", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11725" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { 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"https://www.uniprot.org/uniprotkb/A1Z8S6" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "A1Z8T3-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1Z8T3", "url": "https://www.uniprot.org/uniprotkb/A1Z8T3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 99, "chemical_mass": 10869.0, "gene_names": "Dmel\\CG18343;CG18343;Dmel\\CG18343;Dmel_CG18343", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "A1Z8V2-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1Z8V2", "url": "https://www.uniprot.org/uniprotkb/A1Z8V2" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", 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"url": "https://www.uniprot.org/uniprotkb/A1ZA52" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A1ZA52", "url": "https://www.uniprot.org/uniprotkb/A1ZA52" } ], "pmid": "" } ], "biological_process": [ { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "A1ZA52", "url": "https://www.uniprot.org/uniprotkb/A1ZA52" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "A1ZA97-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1ZA97", "url": "https://www.uniprot.org/uniprotkb/A1ZA97" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 559, 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"sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "A1ZAD7-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1ZAD7", "url": "https://www.uniprot.org/uniprotkb/A1ZAD7" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 146, "chemical_mass": 16781.0, "gene_names": "Dmel\\CG30100;CG30100;Dmel\\CG30100;Dmel_CG30100;Dromel_CG30100_FBtr0087140_mORF", "protein_name": "Prokaryotic-type class I peptide chain release factors domain-containing protein", "disease": [ { "disease_id": "DOID:0110807", "name": "hereditary spastic paraplegia 55", "description": "A hereditary spastic paraplegia that has_material_basis_in mutation in the C12ORF65 gene on chromosome 12q24.", "url": "https://disease-ontology.org/term/DOID:0110807", "evidence": [ { "id": "0110807", "database": "AGR", "url": 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"biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "E1JHL4-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "E1JHL4", "url": "https://www.uniprot.org/uniprotkb/E1JHL4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 50, "chemical_mass": 5511.0, "gene_names": "Dmel\\CG42502;CG42502;Dmel\\CG42502;Dmel_CG42502;Dromel_CG10570_FBtr0081122_uORF", "protein_name": "50S ribosomal protein L35", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "E1JHN0-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "E1JHN0", "url": "https://www.uniprot.org/uniprotkb/E1JHN0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster 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"glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 424, "chemical_mass": 47534.0, "gene_names": "Mkk4;142758_at;CG9738;CT27508;D-MKK4;DMKK4;Dmel\\CG9738;Dmel_CG9738;JNKK2;MAPKK4;MKK4;Mkk4;Mpk4;P-MKK4;SEK1/MKK4;dMKK4;dMkk4;mkk4", "protein_name": "mitogen-activated protein kinase kinase", "disease": [ { "disease_id": "DOID:0050865", "name": "tongue squamous cell carcinoma", "description": "A head and neck squamous cell carcinoma that is located_in the tongue.", "url": "https://disease-ontology.org/term/DOID:0050865", "evidence": [ { "id": "0050865", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050865" } ], "weight": 0.0 }, { "disease_id": "DOID:0050933", "name": "ovarian serous carcinoma", "description": "An ovarian carcinoma that has_material_basis_in the lining of the ovary and produces a serum-like fluid.", "url": "https://disease-ontology.org/term/DOID:0050933", "evidence": [ { "id": "0050933", "database": 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"https://www.alliancegenome.org/disease/DOID:1793" } ], "weight": 0.0 }, { "disease_id": "DOID:224", "name": "transient cerebral ischemia", "description": "A brain ischemia that is characterized by ischemia of brief duration and without resultant tissue death.", "url": "https://disease-ontology.org/term/DOID:224", "evidence": [ { "id": "224", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:224" } ], "weight": 0.0 }, { "disease_id": "DOID:2876", "name": "laryngeal squamous cell carcinoma", "description": "A laryngeal carcinoma that has_material_basis_in squamous cells.", "url": "https://disease-ontology.org/term/DOID:2876", "evidence": [ { "id": "2876", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2876" } ], "weight": 0.0 }, { "disease_id": "DOID:3008", "name": "invasive ductal carcinoma", "description": "A breast ductal carcinoma that is characterized by infiltration into the fibrous or fatty tissue of the breast outside of the duct where it originated.", "url": "https://disease-ontology.org/term/DOID:3008", "evidence": [ { "id": "3008", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3008" } ], "weight": 0.0 }, { "disease_id": "DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:3717", "name": "gastric adenocarcinoma", "description": "A stomach carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:3717", "evidence": [ { "id": "3717", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3717" } ], "weight": 0.0 }, { "disease_id": "DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.", "url": "https://disease-ontology.org/term/DOID:3908", "evidence": [ { "id": "3908", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ], "weight": 0.0 }, { "disease_id": "DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.", "url": "https://disease-ontology.org/term/DOID:684", "evidence": [ { "id": "684", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:684" } ], "weight": 0.0 }, { "disease_id": "DOID:8634", "name": "prostate carcinoma in situ", "description": "An in situ carcinoma that is located_in the prostate.", "url": "https://disease-ontology.org/term/DOID:8634", "evidence": [ { "id": "8634", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8634" } ], "weight": 0.0 }, { "disease_id": "DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum.", "url": "https://disease-ontology.org/term/DOID:9256", "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ], "weight": 0.0 }, { "disease_id": "DOID:9261", "name": "nasopharynx carcinoma", "description": "A pharynx cancer that is located in the nasopharynx, the uppermost region of the pharynx or throat, where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.", "url": "https://disease-ontology.org/term/DOID:9261", "evidence": [ { "id": "9261", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9261" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "O61444", "url": "https://www.uniprot.org/uniprotkb/O61444" } ], "pmid": "" }, { "name": "protein tyrosine kinase activity", "id": "GO:0004713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004713", "evidence": [ { "database": "UniProtKB", "id": "O61444", "url": "https://www.uniprot.org/uniprotkb/O61444" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "O61444", "url": "https://www.uniprot.org/uniprotkb/O61444" } ], "pmid": "" }, { "name": "MAP kinase kinase activity", "id": "GO:0004708", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004708", "evidence": [ { "database": "UniProtKB", "id": "O61444", "url": "https://www.uniprot.org/uniprotkb/O61444" } ], "pmid": "" } ], "cellular_component": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O61444", "url": "https://www.uniprot.org/uniprotkb/O61444" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "O61444", "url": "https://www.uniprot.org/uniprotkb/O61444" } ], "pmid": "" } ], "biological_process": [ { "name": "MAPK cascade", "id": "GO:0000165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000165", "evidence": [ { "database": "UniProtKB", "id": "O61444", "url": "https://www.uniprot.org/uniprotkb/O61444" } ], "pmid": "" }, { "name": "JNK cascade", "id": "GO:0007254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007254", "evidence": [ { "database": "UniProtKB", "id": "O61444", "url": "https://www.uniprot.org/uniprotkb/O61444" } ], "pmid": "" }, { "name": "tumor necrosis factor-mediated signaling pathway", "id": "GO:0033209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033209", "evidence": [ { "database": "UniProtKB", "id": "O61444", "url": "https://www.uniprot.org/uniprotkb/O61444" } ], "pmid": "" }, { "name": "neuron development", "id": "GO:0048666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048666", "evidence": [ { "database": "UniProtKB", "id": "O61444", "url": "https://www.uniprot.org/uniprotkb/O61444" } ], "pmid": "" }, { "name": "cellular response to stress", "id": "GO:0033554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033554", "evidence": [ { "database": "UniProtKB", "id": "O61444", "url": "https://www.uniprot.org/uniprotkb/O61444" } ], "pmid": "" }, { "name": "positive regulation of programmed cell death", "id": "GO:0043068", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043068", "evidence": [ { "database": "UniProtKB", "id": "O61444", "url": "https://www.uniprot.org/uniprotkb/O61444" } ], "pmid": "" }, { "name": "regulation of adult chitin-containing cuticle pigmentation", "id": "GO:0048082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048082", "evidence": [ { "database": "UniProtKB", "id": "O61444", "url": "https://www.uniprot.org/uniprotkb/O61444" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "O76339-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "O76339", "url": "https://www.uniprot.org/uniprotkb/O76339" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 194, "chemical_mass": 21839.0, "gene_names": "agt;Agt;BG:DS00004.10;CG1303;DmAGT;Dmel\\CG1303;Dmel_CG1303;agt", "protein_name": "Methylated-DNA--protein-cysteine methyltransferase", "disease": [ { "disease_id": "DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder.", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ], "weight": 0.0 }, { "disease_id": "DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland.", "url": "https://disease-ontology.org/term/DOID:1612", "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ], "weight": 0.0 }, { "disease_id": "DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas.", "url": "https://disease-ontology.org/term/DOID:1793", "evidence": [ { "id": "1793", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ], "weight": 0.0 }, { "disease_id": "DOID:1798", "name": "pancreatic endocrine carcinoma", "description": "An islet cell tumor that has_material_basis_in epithelial cells.", "url": "https://disease-ontology.org/term/DOID:1798", "evidence": [ { "id": "1798", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1798" } ], "weight": 0.0 }, { "disease_id": "DOID:1909", "name": "melanoma", "description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye.", "url": "https://disease-ontology.org/term/DOID:1909", "evidence": [ { "id": "1909", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1909" } ], "weight": 0.0 }, { "disease_id": "DOID:234", "name": "colon adenocarcinoma", "description": "A colon carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:234", "evidence": [ { "id": "234", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:234" } ], "weight": 0.0 }, { "disease_id": "DOID:2893", "name": "cervix carcinoma", "description": "A cervical cancer that is located_in the cervix uteri or located_in the cervical area and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.", "url": "https://disease-ontology.org/term/DOID:2893", "evidence": [ { "id": "2893", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2893" } ], "weight": 0.0 }, { "disease_id": "DOID:2999", "name": "granulosa cell tumor", "description": "A sex cord-gonadal stromal tumor that has_material_basis_in granulosa cells and arises from the sex cord stroma.", "url": "https://disease-ontology.org/term/DOID:2999", "evidence": [ { "id": "2999", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2999" } ], "weight": 0.0 }, { "disease_id": "DOID:3068", "name": "glioblastoma", "description": "A malignant astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes.", "url": "https://disease-ontology.org/term/DOID:3068", "evidence": [ { "id": "3068", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3068" } ], "weight": 0.0 }, { "disease_id": "DOID:3181", "name": "oligodendroglioma", "description": "", "url": "https://disease-ontology.org/term/DOID:3181", "evidence": [ { "id": "3181", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3181" } ], "weight": 0.0 }, { "disease_id": "DOID:3587", "name": "pancreatic ductal carcinoma", "description": "A pancreatic carcinoma located_in the pancreatic duct.", "url": "https://disease-ontology.org/term/DOID:3587", "evidence": [ { "id": "3587", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3587" } ], "weight": 0.0 }, { "disease_id": "DOID:3748", "name": "esophagus squamous cell carcinoma", "description": "An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus.", "url": "https://disease-ontology.org/term/DOID:3748", "evidence": [ { "id": "3748", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3748" } ], "weight": 0.0 }, { "disease_id": "DOID:4947", "name": "cholangiocarcinoma", "description": "A bile duct adenocarcinoma that has_material_basis_in bile duct epithelial cells.", "url": "https://disease-ontology.org/term/DOID:4947", "evidence": [ { "id": "4947", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4947" } ], "weight": 0.0 }, { "disease_id": "DOID:5577", "name": "gastrinoma", "description": "A neuroendocrine tumor that results_in an overproduction of gastric acid.", "url": "https://disease-ontology.org/term/DOID:5577", "evidence": [ { "id": "5577", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5577" } ], "weight": 0.0 }, { "disease_id": "DOID:768", "name": "retinoblastoma", "description": "A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives_from the tissues of the retina.", "url": "https://disease-ontology.org/term/DOID:768", "evidence": [ { "id": "768", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:768" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "methylated-DNA-[protein]-cysteine S-methyltransferase activity", "id": "GO:0003908", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003908", "evidence": [ { "database": "UniProtKB", "id": "O76339", "url": "https://www.uniprot.org/uniprotkb/O76339" } ], "pmid": "" } ], "biological_process": [ { "name": "DNA alkylation repair", "id": "GO:0006307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006307", "evidence": [ { "database": "UniProtKB", "id": "O76339", "url": "https://www.uniprot.org/uniprotkb/O76339" } ], "pmid": "" }, { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "O76339", "url": "https://www.uniprot.org/uniprotkb/O76339" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "O76521-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "O76521", "url": "https://www.uniprot.org/uniprotkb/O76521" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 543, "chemical_mass": 60010.0, "gene_names": "Kap-alpha1;CG8548;Dalpha1;Dmalpha1;Dmel\\CG8548;Dmel_CG8548;IMPalpha1;Imp alpha1;Imp-alpha1;Impalpha1;Kap alpha1;Kap-alpha-1;Kap-alpha1;Kapalpha1S1;Kpna1;alphaKap1;anon-WO0118547.276;imp alpha1;imp-alpha1;impalpha1", "protein_name": "Importin subunit alpha", "disease": [], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O76521", "url": "https://www.uniprot.org/uniprotkb/O76521" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O76521", "url": "https://www.uniprot.org/uniprotkb/O76521" } ], "pmid": "" }, { "name": "NLS-dependent protein nuclear import complex", "id": "GO:0042564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042564", "evidence": [ { "database": "UniProtKB", "id": "O76521", "url": "https://www.uniprot.org/uniprotkb/O76521" } ], "pmid": "" } ], "biological_process": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "O76521", "url": "https://www.uniprot.org/uniprotkb/O76521" } ], "pmid": "" }, { "name": "anatomical structure morphogenesis", "id": "GO:0009653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009653", "evidence": [ { "database": "UniProtKB", "id": "O76521", "url": "https://www.uniprot.org/uniprotkb/O76521" } ], "pmid": "" }, { "name": "NLS-bearing protein import into nucleus", "id": "GO:0006607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006607", "evidence": [ { "database": "UniProtKB", "id": "O76521", "url": "https://www.uniprot.org/uniprotkb/O76521" } ], "pmid": "" } ], "molecular_function": [ { "name": "nuclear localization sequence binding", "id": "GO:0008139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008139", "evidence": [ { "database": "UniProtKB", "id": "O76521", "url": "https://www.uniprot.org/uniprotkb/O76521" } ], "pmid": "" }, { "name": "nuclear import signal receptor activity", "id": "GO:0061608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061608", "evidence": [ { "database": "UniProtKB", "id": "O76521", "url": "https://www.uniprot.org/uniprotkb/O76521" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "O76742-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 207, "chemical_mass": 23331.0, "gene_names": "Rab7;AAF56218;CG5915;DRAB7;DRab7;Dm Rab7;DmRab7;Dmel\\CG5915;Drab7;O76742;RAB7;Rab-7;Rab-r7;Rab7A;Rab7;dRab7;drab7;rab7", "protein_name": "Ras-related protein Rab7", "disease": [ { "disease_id": "DOID:0050539", "name": "Charcot-Marie-Tooth disease type 2", "description": "A Charcot-Marie-Tooth disease characterized by abnormalities in the axon of the peripheral nerve cell.", "url": "https://disease-ontology.org/term/DOID:0050539", "evidence": [ { "id": "0050539", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050539" } ], "weight": 0.0 }, { "disease_id": "DOID:0110159", "name": "Charcot-Marie-Tooth disease type 2B", "description": "A Charcot-Marie-Tooth disease type 2 that has_material_basis_in heterozygous mutation in the RAB7 gene on chromosome 3q21.", "url": "https://disease-ontology.org/term/DOID:0110159", "evidence": [ { "id": "0110159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110159" } ], "weight": 0.0 }, { "disease_id": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" }, { "name": "phagocytosis", "id": "GO:0006909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006909", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" }, { "name": "endosome to lysosome transport", "id": "GO:0008333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008333", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" }, { "name": "endosomal transport", "id": "GO:0016197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016197", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" }, { "name": "symbiont entry into host cell", "id": "GO:0046718", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046718", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" }, { "name": "endosomal vesicle fusion", "id": "GO:0034058", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034058", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" }, { "name": "T-tubule organization", "id": "GO:0033292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033292", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" }, { "name": "endocytic recycling", "id": "GO:0032456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032456", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" }, { "name": "Rab protein signal transduction", "id": "GO:0032482", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032482", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" }, { "name": "phagosome-lysosome fusion", "id": "GO:0090385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090385", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" }, { "name": "endosome to lysosome transport via multivesicular body sorting pathway", "id": "GO:0032510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032510", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" }, { "name": "autophagosome-lysosome fusion", "id": "GO:0061909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061909", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" }, { "name": "clathrin-dependent endocytosis involved in vitellogenesis", "id": "GO:0061883", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061883", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" }, { "name": "border follicle cell migration", "id": "GO:0007298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007298", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" }, { "name": "wing disc dorsal/ventral pattern formation", "id": "GO:0048190", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048190", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" }, { "name": "secretory granule-lysosome fusion", "id": "GO:0160156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160156", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" } ], "cellular_component": [ { "name": "autophagosome membrane", "id": "GO:0000421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000421", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O76742", "url": "https://www.uniprot.org/uniprotkb/O76742" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": 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"chemical_mass": 94369.0, "gene_names": "EG:125H10.1;BEST:CK01670;CG3777;CK01670;Dmel\\CG3777;Dmel_CG3777;EG:125H10.1", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "O76874-1", "start_pos": "245", "end_pos": "245", "site_lbl": "Thr245", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 245, "start_aa": "Thr", "end_pos": 245, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr245", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ] }, { "uniprot_canonical_ac": "O76874-1", "start_pos": "290", "end_pos": "290", "site_lbl": "Thr290", "weight": 0.0, "glycosylation": [ { 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"biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q0E8K6-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q0E8K6", "url": "https://www.uniprot.org/uniprotkb/Q0E8K6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 306, "chemical_mass": 35219.0, "gene_names": "Dmel\\CG34140;CG34140;CG7042;Dmel\\CG34140;Dmel_CG34140", "protein_name": "tRNA pseudouridine synthase", "disease": [], "biological_process": [ { "name": "tRNA pseudouridine synthesis", "id": "GO:0031119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031119", "evidence": [ { "database": "UniProtKB", "id": "Q0E8K6", "url": "https://www.uniprot.org/uniprotkb/Q0E8K6" } ], "pmid": "" } ], "molecular_function": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": 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"evidence": [ { "database": "UniProtKB", "id": "Q0E8V7", "url": "https://www.uniprot.org/uniprotkb/Q0E8V7" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q0E906-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q0E906", "url": "https://www.uniprot.org/uniprotkb/Q0E906" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 77, "chemical_mass": 8977.0, "gene_names": "Dmel\\CG34115;CG34115;Dmel\\CG34115;Dmel_CG34115", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q0E9B5-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q0E9B5", "url": "https://www.uniprot.org/uniprotkb/Q0E9B5" } ], 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"evidence": [ { "database": "UniProtKB", "id": "Q0KHU4", "url": "https://www.uniprot.org/uniprotkb/Q0KHU4" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q0KHU4", "url": "https://www.uniprot.org/uniprotkb/Q0KHU4" } ], "pmid": "" }, { "name": "small GTPase-mediated signal transduction", "id": "GO:0007264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264", "evidence": [ { "database": "UniProtKB", "id": "Q0KHU4", "url": "https://www.uniprot.org/uniprotkb/Q0KHU4" } ], "pmid": "" }, { "name": "establishment of cell polarity", "id": "GO:0030010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030010", "evidence": [ { "database": "UniProtKB", "id": "Q0KHU4", "url": "https://www.uniprot.org/uniprotkb/Q0KHU4" } ], "pmid": "" }, { "name": "ameboidal-type cell migration", "id": "GO:0001667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001667", "evidence": [ { "database": "UniProtKB", "id": "Q0KHU4", "url": "https://www.uniprot.org/uniprotkb/Q0KHU4" } ], "pmid": "" }, { "name": "cellular process involved in reproduction in multicellular organism", "id": "GO:0022412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022412", "evidence": [ { "database": "UniProtKB", "id": "Q0KHU4", "url": "https://www.uniprot.org/uniprotkb/Q0KHU4" } ], "pmid": "" }, { "name": "melanization defense response", "id": "GO:0035006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035006", "evidence": [ { "database": "UniProtKB", "id": "Q0KHU4", "url": "https://www.uniprot.org/uniprotkb/Q0KHU4" } ], "pmid": "" }, { "name": "hemocyte migration", "id": "GO:0035099", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035099", "evidence": [ { "database": "UniProtKB", "id": "Q0KHU4", "url": "https://www.uniprot.org/uniprotkb/Q0KHU4" } ], "pmid": "" } ], "molecular_function": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "Q0KHU4", "url": "https://www.uniprot.org/uniprotkb/Q0KHU4" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q0KHU4", "url": "https://www.uniprot.org/uniprotkb/Q0KHU4" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "Q0KHU4", "url": "https://www.uniprot.org/uniprotkb/Q0KHU4" } ], "pmid": "" } ], "cellular_component": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q0KHU4", "url": "https://www.uniprot.org/uniprotkb/Q0KHU4" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "Q0KHU4-1", "start_pos": "195", "end_pos": "195", "site_lbl": "Thr195", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 195, "start_aa": "Thr", "end_pos": 195, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr195", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ] }, { "uniprot_canonical_ac": "Q0KHU4-1", "start_pos": "321", "end_pos": "321", "site_lbl": "Thr321", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 321, "start_aa": "Thr", "end_pos": 321, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr321", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ] }, { "uniprot_canonical_ac": "Q0KHU4-1", "start_pos": "571", "end_pos": "571", "site_lbl": "Thr571", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 571, "start_aa": "Thr", "end_pos": 571, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr571", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ] } ], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q0KHX4-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q0KHX4", "url": "https://www.uniprot.org/uniprotkb/Q0KHX4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 92, "chemical_mass": 9915.0, "gene_names": "Dmel\\CG42259;CG42259;C;Dmel\\CG42259;Dmel_CG42259;anon-1Ea", "protein_name": "TIL domain-containing protein", "disease": [], "cellular_component": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q0KHX4", "url": "https://www.uniprot.org/uniprotkb/Q0KHX4" } ], "pmid": "" } ], "molecular_function": [ { "name": "peptidase inhibitor activity", "id": "GO:0030414", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030414", "evidence": [ { "database": "UniProtKB", "id": "Q0KHX4", "url": "https://www.uniprot.org/uniprotkb/Q0KHX4" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q0KHX4", "url": "https://www.uniprot.org/uniprotkb/Q0KHX4" } ], "pmid": "" } ], "biological_process": [ { "name": "response to wounding", "id": "GO:0009611", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009611", "evidence": [ { "database": "UniProtKB", "id": "Q0KHX4", "url": "https://www.uniprot.org/uniprotkb/Q0KHX4" } ], "pmid": "" }, { "name": "hemolymph coagulation", "id": "GO:0042381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042381", "evidence": [ { "database": "UniProtKB", "id": "Q0KHX4", "url": "https://www.uniprot.org/uniprotkb/Q0KHX4" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q0KHZ6-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q0KHZ6", "url": "https://www.uniprot.org/uniprotkb/Q0KHZ6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 253, "chemical_mass": 27218.0, "gene_names": "Etfb;CG 7834;CG7834;Dmel\\CG7834;ETFB;Etfb;Q0KHZ6", "protein_name": "Electron transfer flavoprotein subunit beta", "disease": [ { "disease_id": "DOID:0060358", "name": "multiple acyl-CoA dehydrogenase deficiency", "description": "An inherited metabolic disorder characterized by the body's inability to break down proteins and fats to produce energy. It is a disorder of fatty acid, amino acid, and choline metabolism and has an autosomal recessive inheritance pattern. It has_material_basis_in mutations in the ETFA, ETFB and ETFDH genes. It presents three clinical phenotypes: a neonatal-onset form with congenital anomalies (type I), a neonatal-onset form without congenital anomalies (type II), and a late-onset form (type III). The neonatal-onset forms are usually fatal.", "url": "https://disease-ontology.org/term/DOID:0060358", "evidence": [ { "id": "0060358", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060358" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "mitochondrial electron transfer flavoprotein complex", "id": "GO:0017133", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017133", "evidence": [ { "database": "UniProtKB", "id": "Q0KHZ6", "url": "https://www.uniprot.org/uniprotkb/Q0KHZ6" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q0KHZ6", "url": "https://www.uniprot.org/uniprotkb/Q0KHZ6" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q0KHZ6", "url": "https://www.uniprot.org/uniprotkb/Q0KHZ6" } ], "pmid": "" } ], "molecular_function": [ { "name": "electron transfer activity", "id": "GO:0009055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009055", "evidence": [ { "database": "UniProtKB", "id": "Q0KHZ6", "url": "https://www.uniprot.org/uniprotkb/Q0KHZ6" } ], "pmid": "" } ], "biological_process": [ { "name": "fatty acid beta-oxidation using acyl-CoA dehydrogenase", "id": "GO:0033539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033539", "evidence": [ { "database": "UniProtKB", "id": "Q0KHZ6", "url": "https://www.uniprot.org/uniprotkb/Q0KHZ6" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "Q0KHZ6-1", "start_pos": "161", "end_pos": "161", "site_lbl": "Thr161", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_pos": 161, "start_aa": "Thr", "end_pos": 161, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr161", "evidence": [ { "id": "40245499", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40245499" }, { "id": "Q0KHZ6", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q0KHZ6" } ] } ] } ], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q0KI27-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q0KI27", "url": "https://www.uniprot.org/uniprotkb/Q0KI27" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 305, "chemical_mass": 34782.0, "gene_names": "Dmel\\CG34149;CG12757;CG34149;Dmel\\CG34149;Dmel_CG34149", "protein_name": "BESS domain-containing protein", "disease": [], "molecular_function": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q0KI27", "url": "https://www.uniprot.org/uniprotkb/Q0KI27" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q0KI27", "url": "https://www.uniprot.org/uniprotkb/Q0KI27" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q0KI42-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q0KI42", "url": "https://www.uniprot.org/uniprotkb/Q0KI42" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 897, "chemical_mass": 102149.0, "gene_names": "GluRIIE;CG31201;DmelGluRIIE;Dmel\\CG31201;Dmel_CG31201;GluR-IIE;GluRIIE", "protein_name": "", "disease": [ { "disease_id": "DOID:0081182", "name": "autosomal recessive intellectual developmental disorder 6", "description": "An autosomal recessive intellectual developmental disorder that has_material_basis_in homozygous mutation in the ionotropic glutamate receptor-6 gene (GRIK2) on chromosome 6q16.", "url": "https://disease-ontology.org/term/DOID:0081182", "evidence": [ { "id": "0081182", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0081182" } ], "weight": 0.0 }, { "disease_id": "DOID:12858", "name": "Huntington's disease", "description": "A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities.", "url": "https://disease-ontology.org/term/DOID:12858", "evidence": [ { "id": "12858", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12858" } ], "weight": 0.0 }, { "disease_id": "DOID:1824", "name": "status epilepticus", "description": "", "url": "https://disease-ontology.org/term/DOID:1824", "evidence": [ { "id": "1824", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1824" } ], "weight": 0.0 }, { "disease_id": "DOID:1825", "name": "childhood absence epilepsy", "description": "A childhood electroclinical syndrome that is characterized by brief and frequent absence seizures in children with age of onset between four and ten years.", "url": "https://disease-ontology.org/term/DOID:1825", "evidence": [ { "id": "1825", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1825" } ], "weight": 0.0 }, { "disease_id": "DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:3328", "name": "temporal lobe epilepsy", "description": "A focal epilepsy that is characterized by recurrent, unprovoked focal seizures that originate in the temporal lobe of the brain and last about one or two minutes.", "url": "https://disease-ontology.org/term/DOID:3328", "evidence": [ { "id": "3328", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3328" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "glutamate-gated calcium ion channel activity", "id": "GO:0022849", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022849", "evidence": [ { "database": "UniProtKB", "id": "Q0KI42", "url": "https://www.uniprot.org/uniprotkb/Q0KI42" } ], "pmid": "" }, { "name": "glutamate-gated receptor activity", "id": "GO:0004970", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004970", "evidence": [ { "database": "UniProtKB", "id": "Q0KI42", "url": "https://www.uniprot.org/uniprotkb/Q0KI42" } ], "pmid": "" }, { "name": "transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "id": "GO:1904315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904315", "evidence": [ { "database": "UniProtKB", "id": "Q0KI42", "url": "https://www.uniprot.org/uniprotkb/Q0KI42" } ], "pmid": "" }, { "name": "glutamate receptor activity", "id": "GO:0008066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008066", "evidence": [ { "database": "UniProtKB", "id": "Q0KI42", "url": "https://www.uniprot.org/uniprotkb/Q0KI42" } ], "pmid": "" } ], "cellular_component": [ { "name": "ionotropic glutamate receptor complex", "id": "GO:0008328", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008328", "evidence": [ { "database": "UniProtKB", 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"major mitochondrial derivative", "id": "GO:0016008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016008", "evidence": [ { "database": "UniProtKB", "id": "Q500X4", "url": "https://www.uniprot.org/uniprotkb/Q500X4" } ], "pmid": "" } ], "molecular_function": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "Q500X4", "url": "https://www.uniprot.org/uniprotkb/Q500X4" } ], "pmid": "" }, { "name": "manganese ion binding", "id": "GO:0030145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030145", "evidence": [ { "database": "UniProtKB", "id": "Q500X4", "url": "https://www.uniprot.org/uniprotkb/Q500X4" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q59DY1-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q59DY1", "url": "https://www.uniprot.org/uniprotkb/Q59DY1" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 389, "chemical_mass": 44541.0, "gene_names": "CG14398;CG14398;CG33509;Dmel\\CG33509;Dmel_CG33509;Dro34-0", "protein_name": "CHK kinase-like domain-containing protein", "disease": [], "molecular_function": [ { "name": "ecdysteroid 22-kinase activity", "id": "GO:0106389", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106389", "evidence": [ { "database": "UniProtKB", "id": "Q59DY1", "url": "https://www.uniprot.org/uniprotkb/Q59DY1" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q5LJU1-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q5LJU1", "url": "https://www.uniprot.org/uniprotkb/Q5LJU1" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 123, "chemical_mass": 14085.0, "gene_names": "Cnep1r1;CG41106;Cnep1r1;Dmel\\CG41106;Dmel_CG41106;Nep1r1;NepIrI", "protein_name": "Transmembrane protein 188", "disease": [], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5LJU1", "url": "https://www.uniprot.org/uniprotkb/Q5LJU1" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "Q5LJU1", "url": "https://www.uniprot.org/uniprotkb/Q5LJU1" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q5LJU1", "url": "https://www.uniprot.org/uniprotkb/Q5LJU1" } ], "pmid": "" }, { "name": "protein 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"", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q6II41-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q6II41", "url": "https://www.uniprot.org/uniprotkb/Q6II41" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 99, "chemical_mass": 11158.0, "gene_names": "Dmel\\CG42579;CG42579;Dmel\\CG42579;Dmel_CG42579;HDC19846", "protein_name": "CG15323", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q6IIJ8-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q6IIJ8", "url": "https://www.uniprot.org/uniprotkb/Q6IIJ8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila 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melanogaster [7227]" } ], "length": 107, "chemical_mass": 12016.0, "gene_names": "Dmel\\CG44362;CG44362;Dmel\\CG44362;Dmel_CG44362;FBgn0265469", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q6ILD8-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q6ILD8", "url": "https://www.uniprot.org/uniprotkb/Q6ILD8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 158, "chemical_mass": 18405.0, "gene_names": "BP1014;BP1014;CG34012;Dmel\\CG34012;Dmel_CG34012", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q6ILZ2-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q6ILZ2", "url": "https://www.uniprot.org/uniprotkb/Q6ILZ2" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 426, "chemical_mass": 50138.0, "gene_names": "Grl62c;CG34259;Dmel\\CG34259;Dmel_CG34259;Grl62c", "protein_name": "", "disease": [], "cellular_component": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q6ILZ2", "url": "https://www.uniprot.org/uniprotkb/Q6ILZ2" } ], "pmid": "" } ], "biological_process": [ { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "Q6ILZ2", "url": "https://www.uniprot.org/uniprotkb/Q6ILZ2" } ], "pmid": "" } ], "molecular_function": [ { "name": "ligand-gated channel activity", "id": "GO:0022834", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022834", "evidence": [ { "database": "UniProtKB", "id": "Q6ILZ2", "url": "https://www.uniprot.org/uniprotkb/Q6ILZ2" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q6ILZ3-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q6ILZ3", "url": "https://www.uniprot.org/uniprotkb/Q6ILZ3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 79, "chemical_mass": 9290.0, "gene_names": "Dmel\\CG42841;CG42841;Dmel\\CG42841;Dmel_CG42841", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q6NN55-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q6NN55", "url": "https://www.uniprot.org/uniprotkb/Q6NN55" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 722, "chemical_mass": 81221.0, "gene_names": "oys;CG18445;Dmel\\CG18445;Oys;oys", "protein_name": "Lysophospholipid acyltransferase 6", "disease": [], "cellular_component": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q6NN55", "url": "https://www.uniprot.org/uniprotkb/Q6NN55" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q6NN55", "url": "https://www.uniprot.org/uniprotkb/Q6NN55" } ], "pmid": "" } ], "biological_process": [ { "name": "plasma membrane organization", "id": "GO:0007009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007009", "evidence": [ { "database": "UniProtKB", "id": "Q6NN55", "url": "https://www.uniprot.org/uniprotkb/Q6NN55" } ], "pmid": "" }, { "name": "phospholipid metabolic process", "id": "GO:0006644", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006644", "evidence": [ { "database": "UniProtKB", "id": "Q6NN55", "url": "https://www.uniprot.org/uniprotkb/Q6NN55" } ], "pmid": "" }, { "name": "germ cell migration", "id": "GO:0008354", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008354", "evidence": [ { "database": "UniProtKB", "id": "Q6NN55", "url": "https://www.uniprot.org/uniprotkb/Q6NN55" } ], "pmid": "" }, { "name": "sperm individualization", "id": "GO:0007291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007291", "evidence": [ { "database": "UniProtKB", "id": "Q6NN55", "url": "https://www.uniprot.org/uniprotkb/Q6NN55" } ], "pmid": "" }, { "name": "lipid modification", "id": "GO:0030258", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030258", "evidence": [ { "database": "UniProtKB", "id": "Q6NN55", "url": "https://www.uniprot.org/uniprotkb/Q6NN55" } ], "pmid": "" } ], "molecular_function": [ { "name": "1-acylglycerophosphocholine O-acyltransferase activity", "id": "GO:0047184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047184", "evidence": [ { "database": "UniProtKB", "id": "Q6NN55", "url": "https://www.uniprot.org/uniprotkb/Q6NN55" } ], "pmid": "" }, { "name": "lysophospholipid acyltransferase activity", "id": "GO:0071617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071617", "evidence": [ { "database": "UniProtKB", "id": "Q6NN55", "url": "https://www.uniprot.org/uniprotkb/Q6NN55" } ], "pmid": "" }, { "name": "acyltransferase activity", "id": "GO:0016746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016746", "evidence": [ { "database": "UniProtKB", "id": "Q6NN55", "url": "https://www.uniprot.org/uniprotkb/Q6NN55" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q6NR09-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q6NR09", "url": "https://www.uniprot.org/uniprotkb/Q6NR09" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 421, "chemical_mass": 46099.0, "gene_names": "Egfrap;CG13289;CG13290;CG33993;Dmel\\CG33993;EGFRAP;Egfrap", "protein_name": "EGFR adapter protein", "disease": [], "cellular_component": [ { "name": "apical cortex", "id": "GO:0045179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045179", "evidence": [ { "database": "UniProtKB", "id": "Q6NR09", "url": "https://www.uniprot.org/uniprotkb/Q6NR09" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "Q6NR09", "url": "https://www.uniprot.org/uniprotkb/Q6NR09" } ], "pmid": "" } ], "molecular_function": [ { "name": "receptor tyrosine kinase binding", "id": "GO:0030971", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030971", "evidence": [ { "database": "UniProtKB", "id": "Q6NR09", "url": "https://www.uniprot.org/uniprotkb/Q6NR09" } ], "pmid": "" } ], "biological_process": [ { "name": "negative regulation of epidermal growth factor receptor signaling pathway", "id": "GO:0042059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042059", "evidence": [ { "database": "UniProtKB", "id": "Q6NR09", "url": "https://www.uniprot.org/uniprotkb/Q6NR09" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q7KN94-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q7KN94", "url": "https://www.uniprot.org/uniprotkb/Q7KN94" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 330, "chemical_mass": 34181.0, "gene_names": "wal;BcDNA.LD07532;BcDNA:GH09945;BcDNA:LD07532;CG8996;Dmel\\CG8996;EP2253;ETFA;ETF;Etfa;Etf;P447;l(2)02516;wal", "protein_name": "Electron transfer flavoprotein subunit alpha, mitochondrial", "disease": [ { "disease_id": "DOID:0060358", "name": "multiple acyl-CoA dehydrogenase deficiency", "description": "An inherited metabolic disorder characterized by the body's inability to break down proteins and fats to produce energy. It is a disorder of fatty acid, amino acid, and choline metabolism and has an autosomal recessive inheritance pattern. It has_material_basis_in mutations in the ETFA, ETFB and ETFDH genes. It presents three clinical phenotypes: a neonatal-onset form with congenital anomalies (type I), a neonatal-onset form without congenital anomalies (type II), and a late-onset form (type III). The neonatal-onset forms are usually fatal.", "url": "https://disease-ontology.org/term/DOID:0060358", "evidence": [ { "id": "0060358", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060358" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "mitochondrial electron transfer flavoprotein complex", "id": "GO:0017133", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017133", "evidence": [ { "database": "UniProtKB", "id": "Q7KN94", "url": "https://www.uniprot.org/uniprotkb/Q7KN94" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q7KN94", "url": "https://www.uniprot.org/uniprotkb/Q7KN94" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q7KN94", "url": "https://www.uniprot.org/uniprotkb/Q7KN94" } ], "pmid": "" } ], "molecular_function": [ { "name": "electron transfer activity", "id": "GO:0009055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009055", "evidence": [ { "database": "UniProtKB", "id": "Q7KN94", "url": "https://www.uniprot.org/uniprotkb/Q7KN94" } ], "pmid": "" }, { "name": "flavin adenine dinucleotide binding", "id": "GO:0050660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050660", "evidence": [ { "database": "UniProtKB", "id": "Q7KN94", "url": "https://www.uniprot.org/uniprotkb/Q7KN94" } ], "pmid": "" }, { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "Q7KN94", "url": "https://www.uniprot.org/uniprotkb/Q7KN94" } ], "pmid": "" } ], "biological_process": [ { "name": "fatty acid beta-oxidation using acyl-CoA dehydrogenase", "id": "GO:0033539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033539", "evidence": [ { "database": "UniProtKB", "id": "Q7KN94", "url": "https://www.uniprot.org/uniprotkb/Q7KN94" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q7KT84-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q7KT84", "url": "https://www.uniprot.org/uniprotkb/Q7KT84" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 349, "chemical_mass": 39927.0, "gene_names": "Dmel\\CG18636;CG18636;Dmel\\CG18636;Dmel_CG18636;SP130;SPH130", "protein_name": "Peptidase S1 domain-containing protein", "disease": [], "molecular_function": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "Q7KT84", "url": "https://www.uniprot.org/uniprotkb/Q7KT84" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q7KT84", "url": "https://www.uniprot.org/uniprotkb/Q7KT84" } ], "pmid": "" } ], "cellular_component": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q7KT84", "url": "https://www.uniprot.org/uniprotkb/Q7KT84" } ], "pmid": "" } ], "biological_process": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "Q7KT84", "url": "https://www.uniprot.org/uniprotkb/Q7KT84" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "Q7KT84", "url": "https://www.uniprot.org/uniprotkb/Q7KT84" } ], "pmid": "" }, { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "Q7KT84", "url": "https://www.uniprot.org/uniprotkb/Q7KT84" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q7KTW4-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q7KTW4", "url": "https://www.uniprot.org/uniprotkb/Q7KTW4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 363, "chemical_mass": 40481.0, "gene_names": "Dmel\\CG12974;CG12974;Dmel\\CG12974;Dmel_CG12974", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q7KTX4-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q7KTX4", "url": "https://www.uniprot.org/uniprotkb/Q7KTX4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 1062, "chemical_mass": 124178.0, "gene_names": "CG12982;CG12982;CG33286;Dmel\\CG33286;Dmel_CG33286", "protein_name": "", "disease": [], "molecular_function": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "Q7KTX4", "url": "https://www.uniprot.org/uniprotkb/Q7KTX4" } ], "pmid": "" }, { "name": "beta-tubulin binding", "id": "GO:0048487", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048487", "evidence": [ { "database": "UniProtKB", "id": "Q7KTX4", "url": "https://www.uniprot.org/uniprotkb/Q7KTX4" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q7KU30-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q7KU30", "url": "https://www.uniprot.org/uniprotkb/Q7KU30" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 1017, "chemical_mass": 112352.0, "gene_names": "E23;CG15410;CG3327;DmCG3327;Dmel\\CG3327;Dmel_CG3327;E23;e23", "protein_name": "", "disease": [], "molecular_function": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q7KU30", "url": "https://www.uniprot.org/uniprotkb/Q7KU30" } ], "pmid": "" }, { "name": "ATPase-coupled transmembrane transporter activity", "id": "GO:0042626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042626", "evidence": [ { "database": "UniProtKB", "id": "Q7KU30", "url": "https://www.uniprot.org/uniprotkb/Q7KU30" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q7KU30", "url": "https://www.uniprot.org/uniprotkb/Q7KU30" } ], "pmid": "" }, { "name": "ABC-type transporter activity", "id": "GO:0140359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140359", "evidence": [ { "database": "UniProtKB", "id": "Q7KU30", "url": "https://www.uniprot.org/uniprotkb/Q7KU30" } ], "pmid": "" } ], "cellular_component": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q7KU30", "url": "https://www.uniprot.org/uniprotkb/Q7KU30" } ], "pmid": "" } ], "biological_process": [ { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "Q7KU30", "url": "https://www.uniprot.org/uniprotkb/Q7KU30" } ], "pmid": "" }, { "name": "regulation of circadian rhythm", "id": "GO:0042752", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042752", "evidence": [ { "database": "UniProtKB", "id": "Q7KU30", "url": "https://www.uniprot.org/uniprotkb/Q7KU30" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q7KUG2-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q7KUG2", "url": "https://www.uniprot.org/uniprotkb/Q7KUG2" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 88, "chemical_mass": 9693.0, "gene_names": "CG32084;CG14139;CG32084;CG33269;CG6100;Dmel\\CG33269;Dmel_CG33269;FBgn0053269", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q7KUL3-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q7KUL3", "url": "https://www.uniprot.org/uniprotkb/Q7KUL3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 149, "chemical_mass": 16979.0, "gene_names": "Dmel\\CG13476;CG13476;Dmel\\CG13476;Dmel_CG13476", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q7KUX0-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q7KUX0", "url": "https://www.uniprot.org/uniprotkb/Q7KUX0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 174, "chemical_mass": 20471.0, "gene_names": "Dmel\\CG33252;CG33252;Dmel\\CG33252;Dmel_CG33252", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q7KVM8-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q7KVM8", "url": "https://www.uniprot.org/uniprotkb/Q7KVM8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 292, "chemical_mass": 33258.0, "gene_names": "Dmel\\CG33226;CG10450;CG33226;Dmel\\CG33226;Dmel_CG33226;SP243;SP37;SPH37", "protein_name": "Peptidase S1 domain-containing protein", "disease": [], "molecular_function": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "Q7KVM8", "url": "https://www.uniprot.org/uniprotkb/Q7KVM8" } ], "pmid": "" } ], "cellular_component": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q7KVM8", "url": "https://www.uniprot.org/uniprotkb/Q7KVM8" } ], "pmid": "" } ], "biological_process": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "Q7KVM8", "url": "https://www.uniprot.org/uniprotkb/Q7KVM8" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q7KVT0-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q7KVT0", "url": "https://www.uniprot.org/uniprotkb/Q7KVT0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 184, "chemical_mass": 20095.0, "gene_names": "dec2;CG33223;Dmel\\CG33223;Dmel_CG33223", "protein_name": "Ubiquitin-like domain-containing protein", "disease": [], "biological_process": [ { "name": "egg chorion 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"https://www.ebi.ac.uk/QuickGO/term/GO:0006623", "evidence": [ { "database": "UniProtKB", "id": "Q7PL76", "url": "https://www.uniprot.org/uniprotkb/Q7PL76" } ], "pmid": "" }, { "name": "crinophagy", "id": "GO:0160155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160155", "evidence": [ { "database": "UniProtKB", "id": "Q7PL76", "url": "https://www.uniprot.org/uniprotkb/Q7PL76" } ], "pmid": "" } ], "cellular_component": [ { "name": "HOPS complex", "id": "GO:0030897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030897", "evidence": [ { "database": "UniProtKB", "id": "Q7PL76", "url": "https://www.uniprot.org/uniprotkb/Q7PL76" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q7PL76", "url": "https://www.uniprot.org/uniprotkb/Q7PL76" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", 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"taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q7PLT4", "url": "https://www.uniprot.org/uniprotkb/Q7PLT4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 173, "chemical_mass": 18220.0, "gene_names": "Tim17b;CG40451;Dmel\\CG40451;Dmel_CG40451;Tim17b", "protein_name": "", "disease": [], "cellular_component": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q7PLT4", "url": "https://www.uniprot.org/uniprotkb/Q7PLT4" } ], "pmid": "" }, { "name": "TIM23 mitochondrial import inner membrane translocase complex", "id": "GO:0005744", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005744", "evidence": [ { "database": "UniProtKB", "id": "Q7PLT4", "url": "https://www.uniprot.org/uniprotkb/Q7PLT4" } ], "pmid": "" } ], "biological_process": [ { "name": "protein insertion into mitochondrial inner membrane", "id": "GO:0045039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045039", "evidence": [ { "database": "UniProtKB", "id": "Q7PLT4", "url": "https://www.uniprot.org/uniprotkb/Q7PLT4" } ], "pmid": "" }, { "name": "protein import into mitochondrial matrix", "id": "GO:0030150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030150", "evidence": [ { "database": "UniProtKB", "id": "Q7PLT4", "url": "https://www.uniprot.org/uniprotkb/Q7PLT4" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q86B44-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q86B44", "url": "https://www.uniprot.org/uniprotkb/Q86B44" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 562, "chemical_mass": 61837.0, "gene_names": "Gss1;Gss2;32495;6835;CG32495;CG32497;CG33065;CG6835;Dmel\\CG32495;Dmel\\CG6835;Dmel_CG32495;Dmel_CG6835;GSS;GS;Gss1;Gss2;gss", "protein_name": "Glutathione synthetase", "disease": [ { "disease_id": "DOID:0080699", "name": "glutathione synthetase deficiency", "description": "An amino acid metabolic disorder characterized by the lack of glutathione production.", "url": "https://disease-ontology.org/term/DOID:0080699", "evidence": [ { "id": "0080699", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080699" } ], "weight": 0.0 }, { "disease_id": "DOID:0081034", "name": "glutatione synthetase deficiency with 5-oxoprolinuria", "description": "A glutathione synthetase deficiency that is characterized by massive urinary excretion of 5-oxoproline, metabolic acidosis, hemolytic anemia, and central nervous system damage and that has_material_basis_in homozygous or compound heterozygous mutation in the gene encoding glutathione synthetase (GSS) on chromosome 20q11. The metabolic defect results in decreased levels of cellular glutathione, which overstimulates the synthesis of gamma-glutamylcysteine and its subsequent conversion to 5-oxoproline.", "url": "https://disease-ontology.org/term/DOID:0081034", "evidence": [ { "id": "0081034", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0081034" } ], "weight": 0.0 }, { "disease_id": "DOID:0112252", "name": "congenital nonspherocytic hemolytic anemia 6", "description": "A congenital nonspherocytic hemolytic anemia a mild form of glutathione synthetase deficiency characterized by hemolytic anemia and deficiency in GSH that is limited to the red blood cells, with nucleated cells able to maintain normal or near normal expression levels that has_material_basis_in homozygous or compound heterozygous mutation in GSS on chromosome 20q11.22.", "url": "https://disease-ontology.org/term/DOID:0112252", "evidence": [ { "id": "0112252", "database": "AGR", "url": 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ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "Q86B44", "url": "https://www.uniprot.org/uniprotkb/Q86B44" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q86B44", "url": "https://www.uniprot.org/uniprotkb/Q86B44" } ], "pmid": "" } ], "cellular_component": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q86B44", "url": "https://www.uniprot.org/uniprotkb/Q86B44" } ], "pmid": "" } ], "biological_process": [ { "name": "detoxification of arsenic-containing substance", "id": "GO:0071722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071722", "evidence": [ { "database": "UniProtKB", "id": "Q86B44", "url": "https://www.uniprot.org/uniprotkb/Q86B44" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q86B53-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q86B53", "url": "https://www.uniprot.org/uniprotkb/Q86B53" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 998, "chemical_mass": 113207.0, "gene_names": "CG33172;CG8473;Dmel\\CG33172", "protein_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "disease": [], "molecular_function": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q86B53", "url": "https://www.uniprot.org/uniprotkb/Q86B53" } ], "pmid": "" }, { "name": "tRNA binding", "id": "GO:0000049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", "evidence": [ { "database": "UniProtKB", "id": "Q86B53", "url": 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} ], "biological_process": [ { "name": "mitochondrial translation", "id": "GO:0032543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032543", "evidence": [ { "database": "UniProtKB", "id": "Q86BM8", "url": "https://www.uniprot.org/uniprotkb/Q86BM8" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q8I079-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8I079", "url": "https://www.uniprot.org/uniprotkb/Q8I079" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 132, "chemical_mass": 14839.0, "gene_names": "Dmel\\CG32640;CG32640;CG32641;Dmel\\CG32640;Dmel\\CG32641;Dmel_CG32640;Dmel_CG32641", "protein_name": "J domain-containing protein", "disease": [], "cellular_component": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": 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"https://www.uniprot.org/uniprotkb/Q9V4E7" } ], "pmid": "" } ], "biological_process": [ { "name": "cellular response to mechanical stimulus", "id": "GO:0071260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071260", "evidence": [ { "database": "UniProtKB", "id": "Q9V4E7", "url": "https://www.uniprot.org/uniprotkb/Q9V4E7" } ], "pmid": "" }, { "name": "gamma-aminobutyric acid transport", "id": "GO:0015812", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015812", "evidence": [ { "database": "UniProtKB", "id": "Q9V4E7", "url": "https://www.uniprot.org/uniprotkb/Q9V4E7" } ], "pmid": "" }, { "name": "amino acid transport", "id": "GO:0006865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006865", "evidence": [ { "database": "UniProtKB", "id": "Q9V4E7", "url": "https://www.uniprot.org/uniprotkb/Q9V4E7" } ], "pmid": "" }, { "name": "sodium ion transmembrane transport", "id": "GO:0035725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035725", "evidence": [ { "database": "UniProtKB", "id": "Q9V4E7", "url": "https://www.uniprot.org/uniprotkb/Q9V4E7" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9V9T0-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V9T0", "url": "https://www.uniprot.org/uniprotkb/Q9V9T0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 263, "chemical_mass": 29173.0, "gene_names": "Dmel\\CG1971;CG1971;Dmel\\CG1971;Dmel_CG1971", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q8IMI5-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8IMI5", "url": "https://www.uniprot.org/uniprotkb/Q8IMI5" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", 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{ "name": "triacylglycerol lipase activity", "id": "GO:0004806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004806", "evidence": [ { "database": "UniProtKB", "id": "Q8IMS3", "url": "https://www.uniprot.org/uniprotkb/Q8IMS3" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q8IMT3-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8IMT3", "url": "https://www.uniprot.org/uniprotkb/Q8IMT3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 420, "chemical_mass": 49657.0, "gene_names": "Dmel\\CG31436;CG13660;CG31436;Dmel\\CG31436;Dmel_CG31436;Dro5-10", "protein_name": "CHK kinase-like domain-containing protein", "disease": [], "molecular_function": [ { "name": "ecdysteroid 22-kinase activity", "id": "GO:0106389", "url": 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"database": "UniProtKB", "id": "Q8IR11", "url": "https://www.uniprot.org/uniprotkb/Q8IR11" } ], "pmid": "" } ], "molecular_function": [ { "name": "structural constituent of chitin-based cuticle", "id": "GO:0005214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005214", "evidence": [ { "database": "UniProtKB", "id": "Q8IR11", "url": "https://www.uniprot.org/uniprotkb/Q8IR11" } ], "pmid": "" }, { "name": "structural constituent of chitin-based larval cuticle", "id": "GO:0008010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008010", "evidence": [ { "database": "UniProtKB", "id": "Q8IR11", "url": "https://www.uniprot.org/uniprotkb/Q8IR11" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q8IR70-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8IR70", "url": "https://www.uniprot.org/uniprotkb/Q8IR70" } ], "common_name": "Fruit 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"name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8IRD7", "url": "https://www.uniprot.org/uniprotkb/Q8IRD7" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 71, "chemical_mass": 7760.0, "gene_names": "Drsl3;CG10813;CG32283;CT30310;Dmel\\CG32283;Dmel_CG32283;Dro-3;Dro3;Drs-lE;Drsl3;dro3;drsl3", "protein_name": "", "disease": [], "cellular_component": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q8IRD7", "url": "https://www.uniprot.org/uniprotkb/Q8IRD7" } ], "pmid": "" } ], "biological_process": [ { "name": "defense response", "id": "GO:0006952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006952", "evidence": [ { "database": "UniProtKB", "id": "Q8IRD7", "url": "https://www.uniprot.org/uniprotkb/Q8IRD7" } ], "pmid": "" }, { "name": "defense response to fungus", "id": "GO:0050832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050832", "evidence": [ { "database": "UniProtKB", "id": "Q8IRD7", "url": "https://www.uniprot.org/uniprotkb/Q8IRD7" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q8IRE5-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8IRE5", "url": "https://www.uniprot.org/uniprotkb/Q8IRE5" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 130, "chemical_mass": 13919.0, "gene_names": "BcDNA:GM08588;BcDNA:GM08588;CG32280;Dmel\\CG32280;Dmel_CG32280", "protein_name": "LITAF domain-containing protein", "disease": [ { "disease_id": "DOID:0110151", "name": "Charcot-Marie-Tooth disease type 1C", "description": "A Charcot-Marie-Tooth disease type 1 that has_material_basis_in 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"pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q8IRH1-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8IRH1", "url": "https://www.uniprot.org/uniprotkb/Q8IRH1" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 1075, "chemical_mass": 122759.0, "gene_names": "Psa;CG1009;Dmel\\CG1009;Dmel_CG1009;PSA;Psa;dPSA;dPsa;l(3)06226", "protein_name": "Puromycin-sensitive aminopeptidase", "disease": [], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q8IRH1", "url": "https://www.uniprot.org/uniprotkb/Q8IRH1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { 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"Q9VA66", "url": "https://www.uniprot.org/uniprotkb/Q9VA66" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VA71-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VA71", "url": "https://www.uniprot.org/uniprotkb/Q9VA71" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 420, "chemical_mass": 47918.0, "gene_names": "Q9VA71;AMSH;Amsh;CG2224;Dmel\\CG2224;Dmel_CG2224;Q9VA71", "protein_name": "MPN domain-containing protein", "disease": [], "cellular_component": [ { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "Q9VA71", "url": "https://www.uniprot.org/uniprotkb/Q9VA71" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": 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{ "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VCY5", "url": "https://www.uniprot.org/uniprotkb/Q9VCY5" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 337, "chemical_mass": 39932.0, "gene_names": "CG13844;CG13844;CG33110;CG6926;Dmel\\CG33110;Dmel_CG33110", "protein_name": "Elongation of very long chain fatty acids protein", "disease": [], "cellular_component": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q9VCY5", "url": "https://www.uniprot.org/uniprotkb/Q9VCY5" } ], "pmid": "" } ], "biological_process": [ { "name": "sphingolipid biosynthetic process", "id": "GO:0030148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030148", "evidence": [ { "database": "UniProtKB", "id": "Q9VCY5", "url": "https://www.uniprot.org/uniprotkb/Q9VCY5" } ], "pmid": "" }, { "name": "fatty acid elongation", "id": "GO:0030497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030497", "evidence": [ { "database": "UniProtKB", "id": "Q9VCY5", "url": "https://www.uniprot.org/uniprotkb/Q9VCY5" } ], "pmid": "" }, { "name": "fatty acid elongation, monounsaturated fatty acid", "id": "GO:0034625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034625", "evidence": [ { "database": "UniProtKB", "id": "Q9VCY5", "url": "https://www.uniprot.org/uniprotkb/Q9VCY5" } ], "pmid": "" }, { "name": "fatty acid elongation, polyunsaturated fatty acid", "id": "GO:0034626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034626", "evidence": [ { "database": "UniProtKB", "id": "Q9VCY5", "url": "https://www.uniprot.org/uniprotkb/Q9VCY5" } ], "pmid": "" }, { "name": "fatty acid elongation, saturated fatty acid", "id": "GO:0019367", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019367", "evidence": [ { "database": "UniProtKB", "id": "Q9VCY5", "url": "https://www.uniprot.org/uniprotkb/Q9VCY5" } ], "pmid": "" }, { "name": "very long-chain fatty acid biosynthetic process", "id": "GO:0042761", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042761", "evidence": [ { "database": "UniProtKB", "id": "Q9VCY5", "url": "https://www.uniprot.org/uniprotkb/Q9VCY5" } ], "pmid": "" } ], "molecular_function": [ { "name": "fatty acid elongase activity", "id": "GO:0009922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009922", "evidence": [ { "database": "UniProtKB", "id": "Q9VCY5", "url": "https://www.uniprot.org/uniprotkb/Q9VCY5" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VD16-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VD16", "url": "https://www.uniprot.org/uniprotkb/Q9VD16" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 189, "chemical_mass": 21499.0, "gene_names": "Dmel\\CG13856;CG13856;Dmel\\CG13856;Dmel_CG13856", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VD22-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VD22", "url": "https://www.uniprot.org/uniprotkb/Q9VD22" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 1136, "chemical_mass": 130188.0, "gene_names": "Dmel\\CG18596;CG18596;Dmel\\CG18596;Dmel_CG18596", "protein_name": "tRNA/rRNA methyltransferase SpoU type domain-containing protein", "disease": [], "molecular_function": [ { "name": "tRNA (guanine) methyltransferase activity", "id": "GO:0016423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016423", "evidence": [ { "database": "UniProtKB", "id": "Q9VD22", "url": "https://www.uniprot.org/uniprotkb/Q9VD22" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q9VD22", "url": "https://www.uniprot.org/uniprotkb/Q9VD22" } ], "pmid": "" }, { "name": "tRNA (guanine(18)-2'-O)-methyltransferase activity", "id": "GO:0141100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141100", "evidence": [ { "database": "UniProtKB", "id": "Q9VD22", "url": "https://www.uniprot.org/uniprotkb/Q9VD22" } ], "pmid": "" } ], "biological_process": [ { "name": "tRNA methylation", "id": "GO:0030488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030488", "evidence": [ { "database": "UniProtKB", "id": "Q9VD22", "url": "https://www.uniprot.org/uniprotkb/Q9VD22" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VD40-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VD40", "url": "https://www.uniprot.org/uniprotkb/Q9VD40" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 597, "chemical_mass": 68239.0, "gene_names": "Dmel\\CG7084;CG7084;Dmel\\CG7084;Dmel_CG7084", "protein_name": "Carcinine transporter", "disease": [ { "disease_id": "DOID:1074", "name": "kidney failure", "description": "A kidney disease characterized by the failure of the kidneys to adequately filter waste products from the blood.", "url": "https://disease-ontology.org/term/DOID:1074", "evidence": [ { "id": "1074", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1074" } ], "weight": 0.0 }, { "disease_id": "DOID:13619", "name": "extrahepatic cholestasis", "description": "A cholestasis resulting from causes located_in bile ducts outside the liver.", "url": 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"weight": 0.0 }, { "disease_id": "DOID:783", "name": "end stage renal disease", "description": "A chronic kidney disease is characterized by non-functioning kidneys, as the final stage in chronic kidney disease.", "url": "https://disease-ontology.org/term/DOID:783", "evidence": [ { "id": "783", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:783" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q9VD40", "url": "https://www.uniprot.org/uniprotkb/Q9VD40" } ], "pmid": "" } ], "molecular_function": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "Q9VD40", "url": "https://www.uniprot.org/uniprotkb/Q9VD40" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VD48-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VD48", "url": "https://www.uniprot.org/uniprotkb/Q9VD48" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 98, "chemical_mass": 10209.0, "gene_names": "BomBc3;BcDNA:RH16331;Bom791;BomBc3;CG5791;Dmel\\CG5791;Dmel_CG5791;bom", "protein_name": "", "disease": [], "cellular_component": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q9VD48", "url": "https://www.uniprot.org/uniprotkb/Q9VD48" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VD53-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": 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"Q9VDA0-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VDA0", "url": "https://www.uniprot.org/uniprotkb/Q9VDA0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 1489, "chemical_mass": 169632.0, "gene_names": "Fancm;CG7922;Dmel\\CG7922;Fancm;cg7922;fancm", "protein_name": "DEAD-box ATP-dependent DNA helicase Fancm", "disease": [ { "disease_id": "DOID:0050865", "name": "tongue squamous cell carcinoma", "description": "A head and neck squamous cell carcinoma that is located_in the tongue.", "url": "https://disease-ontology.org/term/DOID:0050865", "evidence": [ { "id": "0050865", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050865" } ], "weight": 0.0 }, { "disease_id": "DOID:0080872", "name": "primary ovarian insufficiency 15", "description": "A primary ovarian insufficiency that is characterized by onset of oligomenorrhea in the third decade of life, with small ovaries, reduced number of follicles, and elevated gonadotropic hormones and that has_material_basis_in homozygous mutation in the FANCM gene on chromosome 14q21.", "url": "https://disease-ontology.org/term/DOID:0080872", "evidence": [ { "id": "0080872", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080872" } ], "weight": 0.0 }, { "disease_id": "DOID:0111916", "name": "spermatogenic failure 28", "description": "A spermatogenic failure characterized by nonobstructive azoospermia and a Sertoli cell-only phenotype in testes that has_material_basis_in homozygous or compound heterozygous mutation in the FANCM gene on chromosome 14q21.2.", "url": "https://disease-ontology.org/term/DOID:0111916", "evidence": [ { "id": "0111916", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111916" } ], "weight": 0.0 }, { "disease_id": "DOID:13636", "name": "Fanconi anemia", "description": "A congenital 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"" }, { "name": "four-way junction DNA binding", "id": "GO:0000400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000400", "evidence": [ { "database": "UniProtKB", "id": "Q9VDA0", "url": "https://www.uniprot.org/uniprotkb/Q9VDA0" } ], "pmid": "" }, { "name": "four-way junction helicase activity", "id": "GO:0009378", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009378", "evidence": [ { "database": "UniProtKB", "id": "Q9VDA0", "url": "https://www.uniprot.org/uniprotkb/Q9VDA0" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9VDA0", "url": "https://www.uniprot.org/uniprotkb/Q9VDA0" } ], "pmid": "" } ], "biological_process": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "Q9VDA0", "url": "https://www.uniprot.org/uniprotkb/Q9VDA0" } ], "pmid": "" 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"sequence_mut": "M", "comment": "Loss of ATPase and helicase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q9VDA0", "url": "https://www.uniprot.org/uniprotkb/Q9VDA0" }, { "database": "PubMed", "id": "27466228", "url": "https://glygen.org/publication/PubMed/27466228" } ] } ] } ], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VDC3-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VDC3", "url": "https://www.uniprot.org/uniprotkb/Q9VDC3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 142, "chemical_mass": 16964.0, "gene_names": "AP-2sigma;AP-2 sigma;AP-2-sigma;AP-2sigma;AP2-sigma;AP2;CG6056;Dmel\\CG6056;Dmel_CG6056;aps2;cg6056;sigma2-ada;sigma2", "protein_name": "AP complex subunit sigma", "disease": [ { "disease_id": "DOID:0060041", "name": "autism spectrum disorder", "description": "A pervasive 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[ { "name": "ecdysteroid 22-kinase activity", "id": "GO:0106389", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106389", "evidence": [ { "database": "UniProtKB", "id": "Q9VEB7", "url": "https://www.uniprot.org/uniprotkb/Q9VEB7" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VEC0-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VEC0", "url": "https://www.uniprot.org/uniprotkb/Q9VEC0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 135, "chemical_mass": 15012.0, "gene_names": "Dmel\\CG14313;CG14313;Dmel\\CG14313;Dmel_CG14313", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VEC2-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 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"name": "tail-anchored membrane protein insertion into ER membrane", "id": "GO:0071816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071816", "evidence": [ { "database": "UniProtKB", "id": "Q9VEC8", "url": "https://www.uniprot.org/uniprotkb/Q9VEC8" } ], "pmid": "" } ], "molecular_function": [ { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "Q9VEC8", "url": "https://www.uniprot.org/uniprotkb/Q9VEC8" } ], "pmid": "" } ], "cellular_component": [ { "name": "BAT3 complex", "id": "GO:0071818", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071818", "evidence": [ { "database": "UniProtKB", "id": "Q9VEC8", "url": "https://www.uniprot.org/uniprotkb/Q9VEC8" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VEF6-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VEF6", "url": "https://www.uniprot.org/uniprotkb/Q9VEF6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 169, "chemical_mass": 19231.0, "gene_names": "pasi1;CG7713;Dmel\\CG7713;Dmel_CG7713;dmCG7713;pasi1", "protein_name": "", "disease": [], "cellular_component": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9VEF6", "url": "https://www.uniprot.org/uniprotkb/Q9VEF6" } ], "pmid": "" } ], "biological_process": [ { "name": "establishment of glial blood-brain barrier", "id": "GO:0060857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060857", "evidence": [ { "database": "UniProtKB", "id": "Q9VEF6", "url": "https://www.uniprot.org/uniprotkb/Q9VEF6" } ], "pmid": "" }, { "name": "septate junction assembly", "id": "GO:0019991", "url": 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"carbohydrate phosphorylation", "id": "GO:0046835", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046835", "evidence": [ { "database": "UniProtKB", "id": "Q9VEQ0", "url": "https://www.uniprot.org/uniprotkb/Q9VEQ0" } ], "pmid": "" } ], "molecular_function": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q9VEQ0", "url": "https://www.uniprot.org/uniprotkb/Q9VEQ0" } ], "pmid": "" }, { "name": "D-xylulokinase activity", "id": "GO:0004856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004856", "evidence": [ { "database": "UniProtKB", "id": "Q9VEQ0", "url": "https://www.uniprot.org/uniprotkb/Q9VEQ0" } ], "pmid": "" } ], "cellular_component": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q9VEQ0", "url": "https://www.uniprot.org/uniprotkb/Q9VEQ0" } ], "pmid": "" }, { "name": "extracellular 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"Q9XZ10", "url": "https://www.uniprot.org/uniprotkb/Q9XZ10" } ], "pmid": "" }, { "name": "ATPase binding", "id": "GO:0051117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051117", "evidence": [ { "database": "UniProtKB", "id": "Q9XZ10", "url": "https://www.uniprot.org/uniprotkb/Q9XZ10" } ], "pmid": "" } ], "cellular_component": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "Q9XZ10", "url": "https://www.uniprot.org/uniprotkb/Q9XZ10" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9XZ10", "url": "https://www.uniprot.org/uniprotkb/Q9XZ10" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "Q9XZ10", "url": "https://www.uniprot.org/uniprotkb/Q9XZ10" 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"database": "UniProtKB", "id": "Q9VS45", "url": "https://www.uniprot.org/uniprotkb/Q9VS45" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 647, "chemical_mass": 73702.0, "gene_names": "RhoGEF4;CG8606;DRhoGEF4;Dmel\\CG8606;Dmel_CG8606;RhoGEF4;RhoGEF", "protein_name": "", "disease": [ { "disease_id": "DOID:0110192", "name": "Charcot-Marie-Tooth disease type 4H", "description": "A Charcot-Marie-Tooth disease type 4 that has_material_basis_in mutations in the gene encoding frabin (FGD4).", "url": "https://disease-ontology.org/term/DOID:0110192", "evidence": [ { "id": "0110192", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110192" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9VS45", "url": "https://www.uniprot.org/uniprotkb/Q9VS45" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9VS45", "url": "https://www.uniprot.org/uniprotkb/Q9VS45" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "Q9VS45", "url": "https://www.uniprot.org/uniprotkb/Q9VS45" } ], "pmid": "" }, { "name": "mitotic actomyosin contractile ring", "id": "GO:0110085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110085", "evidence": [ { "database": "UniProtKB", "id": "Q9VS45", "url": "https://www.uniprot.org/uniprotkb/Q9VS45" } ], "pmid": "" } ], "biological_process": [ { "name": "positive regulation of stress fiber assembly", "id": "GO:0051496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051496", "evidence": [ { "database": "UniProtKB", "id": "Q9VS45", "url": "https://www.uniprot.org/uniprotkb/Q9VS45" } ], "pmid": "" }, { "name": "positive regulation of Rho protein signal transduction", "id": "GO:0035025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035025", "evidence": [ { "database": "UniProtKB", "id": "Q9VS45", "url": "https://www.uniprot.org/uniprotkb/Q9VS45" } ], "pmid": "" }, { "name": "cleavage furrow ingression", "id": "GO:0036090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036090", "evidence": [ { "database": "UniProtKB", "id": "Q9VS45", "url": "https://www.uniprot.org/uniprotkb/Q9VS45" } ], "pmid": "" } ], "molecular_function": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "Q9VS45", "url": "https://www.uniprot.org/uniprotkb/Q9VS45" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VXV6-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": 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"database": "UniProtKB", "id": "Q9VXV6", "url": "https://www.uniprot.org/uniprotkb/Q9VXV6" } ], "pmid": "" }, { "name": "synaptic vesicle", "id": "GO:0008021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021", "evidence": [ { "database": "UniProtKB", "id": "Q9VXV6", "url": "https://www.uniprot.org/uniprotkb/Q9VXV6" } ], "pmid": "" }, { "name": "trans-Golgi network membrane", "id": "GO:0032588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032588", "evidence": [ { "database": "UniProtKB", "id": "Q9VXV6", "url": "https://www.uniprot.org/uniprotkb/Q9VXV6" } ], "pmid": "" }, { "name": "recycling endosome membrane", "id": "GO:0055038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055038", "evidence": [ { "database": "UniProtKB", "id": "Q9VXV6", "url": "https://www.uniprot.org/uniprotkb/Q9VXV6" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VXW9-1", "species": [ { "name": "Drosophila 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catabolic process", "id": "GO:1902369", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902369", "evidence": [ { "database": "UniProtKB", "id": "Q9VXW9", "url": "https://www.uniprot.org/uniprotkb/Q9VXW9" } ], "pmid": "" } ], "cellular_component": [ { "name": "catalytic step 2 spliceosome", "id": "GO:0071013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071013", "evidence": [ { "database": "UniProtKB", "id": "Q9VXW9", "url": "https://www.uniprot.org/uniprotkb/Q9VXW9" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9W4F5-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9W4F5", "url": "https://www.uniprot.org/uniprotkb/Q9W4F5" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 1767, "chemical_mass": 200075.0, "gene_names": "Ptp4E;4E;CG6899;CT21187;DPTP4E;Dmel\\CG6899;Dmel_CG6899;PTP4E;PtP4E;Ptp4E;R-PTP 4E;ptp4E", "protein_name": "protein-tyrosine-phosphatase", "disease": [ { "disease_id": "DOID:0001816", "name": "angiosarcoma", "description": "A vascular cancer that derives_from the cells that line the walls of blood vessels or lymphatic vessels.", "url": "https://disease-ontology.org/term/DOID:0001816", "evidence": [ { "id": "0001816", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0001816" } ], "weight": 0.0 }, { "disease_id": "DOID:0060108", "name": "brain glioma", "description": "A brain cancer that has_material_basis_in glial cells.", "url": "https://disease-ontology.org/term/DOID:0060108", "evidence": [ { "id": "0060108", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060108" } ], "weight": 0.0 }, { "disease_id": "DOID:0080199", "name": "colorectal carcinoma", "description": "A colorectal cancer that arises from the colon or rectum and invades 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"weight": 0.0 }, { "disease_id": "DOID:3910", "name": "lung adenocarcinoma", "description": "A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:3910", "evidence": [ { "id": "3910", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3910" } ], "weight": 0.0 }, { "disease_id": "DOID:3963", "name": "thyroid gland carcinoma", "description": "A thyroid gland cancer that has_material_basis_in epithelial cells.", "url": "https://disease-ontology.org/term/DOID:3963", "evidence": [ { "id": "3963", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3963" } ], "weight": 0.0 }, { "disease_id": "DOID:4511", "name": "breast angiosarcoma", "description": "An angiosarcoma and sarcoma of breast and vascular neoplasm of breast that is located_in the cells that line the blood vessels within the breast or underarm area.", "url": "https://disease-ontology.org/term/DOID:4511", 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"https://www.ebi.ac.uk/QuickGO/term/GO:0007435", "evidence": [ { "database": "UniProtKB", "id": "Q9VLI4", "url": "https://www.uniprot.org/uniprotkb/Q9VLI4" } ], "pmid": "" }, { "name": "morphogenesis of an epithelium", "id": "GO:0002009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002009", "evidence": [ { "database": "UniProtKB", "id": "Q9VLI4", "url": "https://www.uniprot.org/uniprotkb/Q9VLI4" } ], "pmid": "" }, { "name": "gonad development", "id": "GO:0008406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008406", "evidence": [ { "database": "UniProtKB", "id": "Q9VLI4", "url": "https://www.uniprot.org/uniprotkb/Q9VLI4" } ], "pmid": "" }, { "name": "gonad morphogenesis", "id": "GO:0035262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035262", "evidence": [ { "database": "UniProtKB", "id": "Q9VLI4", "url": "https://www.uniprot.org/uniprotkb/Q9VLI4" } ], "pmid": "" }, { "name": "germ-band shortening", "id": "GO:0007390", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007390", "evidence": [ { "database": "UniProtKB", "id": "Q9VLI4", "url": "https://www.uniprot.org/uniprotkb/Q9VLI4" } ], "pmid": "" }, { "name": "dorsal closure", "id": "GO:0007391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007391", "evidence": [ { "database": "UniProtKB", "id": "Q9VLI4", "url": "https://www.uniprot.org/uniprotkb/Q9VLI4" } ], "pmid": "" }, { "name": "Malpighian tubule morphogenesis", "id": "GO:0007443", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007443", "evidence": [ { "database": "UniProtKB", "id": "Q9VLI4", "url": "https://www.uniprot.org/uniprotkb/Q9VLI4" } ], "pmid": "" }, { "name": "ectodermal digestive tract morphogenesis", "id": "GO:0048567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048567", "evidence": [ { "database": "UniProtKB", "id": "Q9VLI4", "url": "https://www.uniprot.org/uniprotkb/Q9VLI4" } ], "pmid": "" }, { "name": "regulation of Malpighian tubule diameter", "id": "GO:0035297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035297", "evidence": [ { "database": "UniProtKB", "id": "Q9VLI4", "url": "https://www.uniprot.org/uniprotkb/Q9VLI4" } ], "pmid": "" } ], "cellular_component": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9VLI4", "url": "https://www.uniprot.org/uniprotkb/Q9VLI4" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VIY1-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VIY1", "url": "https://www.uniprot.org/uniprotkb/Q9VIY1" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 331, "chemical_mass": 38415.0, "gene_names": "Dmel\\CG10750;CG10750;Dmel\\CG10750;Dmel_CG10750", "protein_name": "DUF4200 domain-containing protein", "disease": [], "cellular_component": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q9VIY1", "url": "https://www.uniprot.org/uniprotkb/Q9VIY1" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VXG0-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VXG0", "url": "https://www.uniprot.org/uniprotkb/Q9VXG0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 357, "chemical_mass": 39703.0, "gene_names": "Cdc50;CDC50;CG9947;Cdc50;Dmel\\CG9947;Dmel_CG9947", "protein_name": "", "disease": [], "cellular_component": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q9VXG0", "url": "https://www.uniprot.org/uniprotkb/Q9VXG0" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q9VXG0", "url": "https://www.uniprot.org/uniprotkb/Q9VXG0" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q9VXG0", "url": "https://www.uniprot.org/uniprotkb/Q9VXG0" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9VXG0", "url": "https://www.uniprot.org/uniprotkb/Q9VXG0" } ], "pmid": "" }, { "name": "phospholipid-translocating ATPase complex", "id": "GO:1990531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990531", "evidence": [ { "database": "UniProtKB", "id": "Q9VXG0", "url": "https://www.uniprot.org/uniprotkb/Q9VXG0" } ], "pmid": "" } ], "biological_process": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q9VXG0", "url": "https://www.uniprot.org/uniprotkb/Q9VXG0" } ], "pmid": "" }, { "name": "phospholipid translocation", "id": "GO:0045332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045332", "evidence": [ { "database": "UniProtKB", "id": "Q9VXG0", "url": "https://www.uniprot.org/uniprotkb/Q9VXG0" } ], "pmid": "" } ], "molecular_function": [ { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "Q9VXG0", "url": "https://www.uniprot.org/uniprotkb/Q9VXG0" } ], "pmid": "" }, { "name": "aminophospholipid flippase activity", "id": "GO:0015247", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015247", "evidence": [ { "database": "UniProtKB", "id": "Q9VXG0", "url": "https://www.uniprot.org/uniprotkb/Q9VXG0" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VYR4-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VYR4", "url": "https://www.uniprot.org/uniprotkb/Q9VYR4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 1174, "chemical_mass": 128145.0, "gene_names": "fw;CG1500;CT3745;Dmel\\CG1500;Dmel_CG1500;Fw;fw-like;fw;wr", "protein_name": "", "disease": [ { "disease_id": "DOID:0051061", "name": "stroke", "description": "A cerebrovascular disease that is characterized by disruption of blood flow to the brain resulting in damage to brain cells due to a lack of oxygen.", "url": "https://disease-ontology.org/term/DOID:0051061", "evidence": [ { "id": "0051061", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0051061" } ], "weight": 0.0 }, { "disease_id": "DOID:0060180", "name": "colitis", "description": "An inflammatory bowel disease that involves inflammation located_in colon.", "url": "https://disease-ontology.org/term/DOID:0060180", "evidence": [ { "id": "0060180", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060180" } ], "weight": 0.0 }, { "disease_id": "DOID:0060903", "name": "thrombosis", "description": "A vascular disease caused by the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.", "url": "https://disease-ontology.org/term/DOID:0060903", "evidence": [ { "id": "0060903", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060903" } ], "weight": 0.0 }, { "disease_id": "DOID:0080600", "name": "COVID-19", "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum.", "url": "https://disease-ontology.org/term/DOID:0080600", "evidence": [ { "id": "0080600", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080600" } ], "weight": 0.0 }, { "disease_id": "DOID:0080998", "name": "acute necrotizing pancreatitis", "description": "An acute pancreatitis that is characterized by one or more areas of necrosis in the pancreas with varying degree of involvement of the surrounding tissues or organ systems.", "url": "https://disease-ontology.org/term/DOID:0080998", "evidence": [ { "id": "0080998", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080998" } ], "weight": 0.0 }, { "disease_id": "DOID:0112313", "name": "brain small vessel disease", "description": "A brain disease characterized by abnormalities in the small blood vessels in the brain.", "url": "https://disease-ontology.org/term/DOID:0112313", "evidence": [ { "id": "0112313", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0112313" } ], "weight": 0.0 }, { "disease_id": "DOID:10230", "name": "aortic atherosclerosis", "description": "An atherosclerosis of the aorta.", "url": "https://disease-ontology.org/term/DOID:10230", "evidence": [ { "id": "10230", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10230" } ], "weight": 0.0 }, { "disease_id": "DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate.", "url": "https://disease-ontology.org/term/DOID:10283", "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ], "weight": 0.0 }, { "disease_id": "DOID:10611", "name": "protein-losing enteropathy", "description": "", "url": "https://disease-ontology.org/term/DOID:10611", "evidence": [ { "id": "10611", "database": 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cells which destroy the exocrine glands that produce tears and saliva.", "url": "https://disease-ontology.org/term/DOID:12894", "evidence": [ { "id": "12894", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12894" } ], "weight": 0.0 }, { "disease_id": "DOID:13378", "name": "Kawasaki disease", "description": "A lymphadenitis characterized by swelling of cervical lymph nodes in infants and young children and inflammation of medium-sized blood vessels and that symptoms of fever, congestion of ocular conjunctivae, reddening of lips, reddening of oral cavity, protuberance of tongue papillae and edema of extremities.", "url": "https://disease-ontology.org/term/DOID:13378", "evidence": [ { "id": "13378", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13378" } ], "weight": 0.0 }, { "disease_id": "DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland.", "url": "https://disease-ontology.org/term/DOID:1612", "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ], "weight": 0.0 }, { "disease_id": "DOID:1936", "name": "atherosclerosis", "description": "An arteriosclerotic cardiovascular disease that is characterized by the build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen. Disease is located within the tunica intima of large and small arteries.", "url": "https://disease-ontology.org/term/DOID:1936", "evidence": [ { "id": "1936", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1936" } ], "weight": 0.0 }, { "disease_id": "DOID:2316", "name": "brain ischemia", "description": "An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand.", "url": "https://disease-ontology.org/term/DOID:2316", "evidence": [ { "id": "2316", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2316" } ], "weight": 0.0 }, { "disease_id": "DOID:2349", "name": "arteriosclerosis", "description": "An artery disease that is characterized by a thickening and hardening of arterial walls in the arteries.", "url": "https://disease-ontology.org/term/DOID:2349", "evidence": [ { "id": "2349", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2349" } ], "weight": 0.0 }, { "disease_id": "DOID:2870", "name": "endometrial adenocarcinoma", "description": "An endometrial carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:2870", "evidence": [ { "id": "2870", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2870" } ], "weight": 0.0 }, { "disease_id": "DOID:2986", "name": "IgA glomerulonephritis", "description": "A glomerulonephritis characterized by build up of IgA antibody in the glomerulus.", "url": "https://disease-ontology.org/term/DOID:2986", "evidence": [ { "id": "2986", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2986" } ], "weight": 0.0 }, { "disease_id": "DOID:2988", "name": "antiphospholipid syndrome", "description": "An autoimmune disease that is characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with characteristic elevated levels of antibodies directed against membrane anionic phospholipids (anticardiolipin).", "url": "https://disease-ontology.org/term/DOID:2988", "evidence": [ { "id": "2988", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2988" } ], "weight": 0.0 }, { "disease_id": "DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:3310", "name": "atopic dermatitis", "description": "An allergic contact dermatitis that is a chronically relapsing inflammatory allergic response located_in the skin that causes itching and flaking.", "url": "https://disease-ontology.org/term/DOID:3310", "evidence": [ { "id": "3310", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3310" } ], "weight": 0.0 }, { "disease_id": "DOID:3393", "name": "coronary artery disease", "description": "An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.", "url": "https://disease-ontology.org/term/DOID:3393", "evidence": [ { "id": "3393", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3393" } ], "weight": 0.0 }, { "disease_id": "DOID:341", "name": "peripheral vascular disease", "description": "A vascular disease that is characterized by obstruction of vessels not within the coronary, aortic arch vasculature, or brain.", "url": "https://disease-ontology.org/term/DOID:341", "evidence": [ { "id": "341", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:341" } ], "weight": 0.0 }, { "disease_id": "DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix.", "url": "https://disease-ontology.org/term/DOID:4362", "evidence": [ { "id": "4362", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4362" } ], "weight": 0.0 }, { "disease_id": "DOID:4449", "name": "macular retinal edema", "description": "", "url": "https://disease-ontology.org/term/DOID:4449", "evidence": [ { "id": "4449", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4449" } ], "weight": 0.0 }, { "disease_id": "DOID:4780", "name": "anti-basement membrane glomerulonephritis", "description": "A Goodpasture syndrome that is characterized by damage to only kidney capillaries.", "url": "https://disease-ontology.org/term/DOID:4780", "evidence": [ { "id": "4780", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4780" } ], "weight": 0.0 }, { "disease_id": "DOID:526", "name": "human immunodeficiency virus infectious disease", "description": "A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 (Lentivirus humimdef1) or Human immunodeficiency virus 2 (Lentivirus humimdef2), which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.", "url": "https://disease-ontology.org/term/DOID:526", "evidence": [ { "id": "526", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:526" } ], "weight": 0.0 }, { "disease_id": "DOID:5419", "name": "schizophrenia", "description": "A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness.", "url": "https://disease-ontology.org/term/DOID:5419", "evidence": [ { "id": "5419", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5419" } ], "weight": 0.0 }, { "disease_id": "DOID:576", "name": "proteinuria", "description": "A kidney disease that is characterized by the presence of excess proteins in the urine.", "url": "https://disease-ontology.org/term/DOID:576", "evidence": [ { "id": "576", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:576" } ], "weight": 0.0 }, { "disease_id": "DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.", "url": "https://disease-ontology.org/term/DOID:5844", "evidence": [ { "id": "5844", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ], "weight": 0.0 }, { "disease_id": "DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.", "url": "https://disease-ontology.org/term/DOID:6000", "evidence": [ { "id": "6000", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ], "weight": 0.0 }, { "disease_id": "DOID:6713", "name": "cerebrovascular disease", "description": "An vascular disease that is characterized by dysfunction of the blood vessels supplying the brain.", "url": "https://disease-ontology.org/term/DOID:6713", "evidence": [ { "id": "6713", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6713" } ], "weight": 0.0 }, { "disease_id": "DOID:676", "name": "systemic juvenile rheumatoid arthritis", "description": "A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint.", "url": "https://disease-ontology.org/term/DOID:676", "evidence": [ { "id": "676", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:676" } ], "weight": 0.0 }, { "disease_id": "DOID:769", "name": "neuroblastoma", "description": "An autonomic nervous system neoplasm that derives_from immature nerve cells.", "url": "https://disease-ontology.org/term/DOID:769", "evidence": [ { "id": "769", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:769" } ], "weight": 0.0 }, { "disease_id": "DOID:8481", "name": "rheumatic myocarditis", "description": "", "url": "https://disease-ontology.org/term/DOID:8481", "evidence": [ { "id": "8481", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8481" } ], "weight": 0.0 }, { "disease_id": "DOID:8577", "name": "ulcerative colitis", "description": "A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores.", "url": "https://disease-ontology.org/term/DOID:8577", "evidence": [ { "id": "8577", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8577" } ], "weight": 0.0 }, { "disease_id": "DOID:8805", "name": "intermediate coronary syndrome", "description": "", "url": "https://disease-ontology.org/term/DOID:8805", "evidence": [ { "id": "8805", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8805" } ], "weight": 0.0 }, { "disease_id": "DOID:8947", "name": "diabetic retinopathy", "description": "", "url": "https://disease-ontology.org/term/DOID:8947", "evidence": [ { "id": "8947", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8947" } ], "weight": 0.0 }, { "disease_id": "DOID:9351", "name": "diabetes mellitus", "description": "A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.", "url": "https://disease-ontology.org/term/DOID:9351", "evidence": [ { "id": "9351", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9351" } ], "weight": 0.0 }, { "disease_id": "DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.", "url": "https://disease-ontology.org/term/DOID:9352", "evidence": [ { "id": "9352", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ], "weight": 0.0 }, { "disease_id": "DOID:9744", "name": "type 1 diabetes mellitus", "description": "A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production.", "url": "https://disease-ontology.org/term/DOID:9744", "evidence": [ { "id": "9744", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9744" } ], "weight": 0.0 }, { "disease_id": "DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.", "url": "https://disease-ontology.org/term/DOID:9970", "evidence": [ { "id": "9970", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9970" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q9VYR4", "url": "https://www.uniprot.org/uniprotkb/Q9VYR4" } ], "pmid": "" }, { "name": "apical junction complex", "id": "GO:0043296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043296", "evidence": [ { "database": "UniProtKB", "id": "Q9VYR4", "url": "https://www.uniprot.org/uniprotkb/Q9VYR4" } ], "pmid": "" } ], "biological_process": [ { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "Q9VYR4", "url": "https://www.uniprot.org/uniprotkb/Q9VYR4" } ], "pmid": "" }, { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "Q9VYR4", "url": "https://www.uniprot.org/uniprotkb/Q9VYR4" } ], "pmid": "" }, { "name": "sensory organ development", "id": "GO:0007423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007423", "evidence": [ { "database": "UniProtKB", "id": "Q9VYR4", "url": "https://www.uniprot.org/uniprotkb/Q9VYR4" } ], "pmid": "" }, { "name": "imaginal disc-derived wing morphogenesis", "id": "GO:0007476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007476", "evidence": [ { "database": "UniProtKB", "id": "Q9VYR4", "url": "https://www.uniprot.org/uniprotkb/Q9VYR4" } ], "pmid": "" }, { "name": "imaginal disc-derived wing hair organization", "id": "GO:0035317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035317", "evidence": [ { "database": "UniProtKB", "id": "Q9VYR4", "url": "https://www.uniprot.org/uniprotkb/Q9VYR4" } ], "pmid": "" }, { "name": "establishment of ommatidial planar polarity", "id": "GO:0042067", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042067", "evidence": [ { "database": "UniProtKB", "id": "Q9VYR4", "url": "https://www.uniprot.org/uniprotkb/Q9VYR4" } ], "pmid": "" } ], "molecular_function": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "Q9VYR4", "url": "https://www.uniprot.org/uniprotkb/Q9VYR4" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q9VYR4", "url": "https://www.uniprot.org/uniprotkb/Q9VYR4" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VUX4-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VUX4", "url": "https://www.uniprot.org/uniprotkb/Q9VUX4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 453, "chemical_mass": 51717.0, "gene_names": "Dmel\\CG5895;CG5895;Dmel\\CG5895;Dmel_CG5895", "protein_name": "", "disease": [], "biological_process": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "Q9VUX4", "url": "https://www.uniprot.org/uniprotkb/Q9VUX4" } ], "pmid": "" } ], "molecular_function": [ { "name": "phosphoric diester hydrolase activity", "id": "GO:0008081", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008081", "evidence": [ { "database": "UniProtKB", "id": "Q9VUX4", "url": "https://www.uniprot.org/uniprotkb/Q9VUX4" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VUU9-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VUU9", "url": "https://www.uniprot.org/uniprotkb/Q9VUU9" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 524, "chemical_mass": 59847.0, "gene_names": "meru;CG12712;CG15714;CG32150;Dmel\\CG32150;Dmel_CG32150;meru", "protein_name": "", "disease": [], "cellular_component": [ { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "Q9VUU9", "url": "https://www.uniprot.org/uniprotkb/Q9VUU9" } ], "pmid": "" }, { "name": "posterior cell cortex", "id": "GO:0061803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061803", "evidence": [ { "database": "UniProtKB", "id": "Q9VUU9", "url": "https://www.uniprot.org/uniprotkb/Q9VUU9" } ], "pmid": "" } ], "biological_process": [ { "name": "asymmetric cell division", "id": "GO:0008356", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008356", "evidence": [ { "database": "UniProtKB", "id": "Q9VUU9", "url": "https://www.uniprot.org/uniprotkb/Q9VUU9" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VQG1-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VQG1", "url": "https://www.uniprot.org/uniprotkb/Q9VQG1" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 326, "chemical_mass": 37253.0, "gene_names": "Snx21;CG3077;DmSNX21;Dmel\\CG3077;Dmel_CG3077;Snx21;snx21", "protein_name": "", "disease": [], "biological_process": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q9VQG1", "url": "https://www.uniprot.org/uniprotkb/Q9VQG1" } ], "pmid": "" } ], "cellular_component": [ { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "Q9VQG1", "url": "https://www.uniprot.org/uniprotkb/Q9VQG1" } ], "pmid": "" } ], "molecular_function": [ { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "Q9VQG1", "url": "https://www.uniprot.org/uniprotkb/Q9VQG1" } ], "pmid": "" }, { "name": "phosphatidylinositol phosphate binding", "id": "GO:1901981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901981", "evidence": [ { "database": "UniProtKB", "id": "Q9VQG1", "url": "https://www.uniprot.org/uniprotkb/Q9VQG1" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VT05-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VT05", "url": "https://www.uniprot.org/uniprotkb/Q9VT05" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 331, "chemical_mass": 36841.0, "gene_names": "CT11439;CG3408;CT11439;Dmel\\CG3408;Dmel_CG3408", "protein_name": "Leucine-rich repeat-containing protein 59", "disease": [], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9VT05", "url": "https://www.uniprot.org/uniprotkb/Q9VT05" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q9VT05", "url": "https://www.uniprot.org/uniprotkb/Q9VT05" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9VT05", "url": "https://www.uniprot.org/uniprotkb/Q9VT05" } ], "pmid": "" }, { "name": "mitochondrial nucleoid", "id": "GO:0042645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042645", "evidence": [ { "database": "UniProtKB", "id": "Q9VT05", "url": "https://www.uniprot.org/uniprotkb/Q9VT05" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VUF9-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VUF9", "url": "https://www.uniprot.org/uniprotkb/Q9VUF9" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 175, "chemical_mass": 19659.0, "gene_names": "Dmel\\CG9628;CG9628;Dmel\\CG9628;Dmel_CG9628", "protein_name": "MARVEL domain-containing protein", "disease": [], "biological_process": [ { "name": "septate junction assembly", "id": "GO:0019991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019991", "evidence": [ { "database": "UniProtKB", "id": "Q9VUF9", "url": "https://www.uniprot.org/uniprotkb/Q9VUF9" } ], "pmid": "" } ], "cellular_component": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9VUF9", "url": "https://www.uniprot.org/uniprotkb/Q9VUF9" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "Q9VUF9-1", "start_pos": "67", "end_pos": "67", "site_lbl": "Thr67", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 67, "start_aa": "Thr", "end_pos": 67, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr67", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ] } ], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VMT1-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 575, "chemical_mass": 63986.0, "gene_names": "tkv;Atkv;Atr25D;Brk25D1;Brk25D2;Brk25D;CG14026;Dmel\\CG14026;Dmel_CG14026;Dtfr;STK-A;TKV1;TKV;TkvA;Tkv;dtfr;kv;l(2)04415;l(2)25Da;str;thv;tkv1;tkva;tkv", "protein_name": "receptor protein serine/threonine 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"https://disease-ontology.org/term/DOID:0110965", "evidence": [ { "id": "0110965", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110965" } ], "weight": 0.0 }, { "disease_id": "DOID:0110978", "name": "brachydactyly type A1D", "description": "A brachydactyly type A1 that has_material_basis_in heterozygous mutation in the BMPR1B gene on chromosome 4q22.", "url": "https://disease-ontology.org/term/DOID:0110978", "evidence": [ { "id": "0110978", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110978" } ], "weight": 0.0 }, { "disease_id": "DOID:0111686", "name": "hereditary mixed polyposis syndrome 2", "description": "A hereditary mixed polyposis syndrome that has_material_basis_in heterozygous mutation in the BMPR1A gene on chromosome 10q23.2.", "url": "https://disease-ontology.org/term/DOID:0111686", "evidence": [ { "id": "0111686", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111686" } ], "weight": 0.0 }, { "disease_id": "DOID:14289", "name": "Ebstein anomaly", "description": "A tricuspid valve disease that is a congenital heart defect in which the septal leaflet of the tricuspid valve is displaced towards the apex of the right ventricle of the heart.", "url": "https://disease-ontology.org/term/DOID:14289", "evidence": [ { "id": "14289", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14289" } ], "weight": 0.0 }, { "disease_id": "DOID:2256", "name": "osteochondrodysplasia", "description": "A bone development disease that results_in defective development of cartilage or bone.", "url": "https://disease-ontology.org/term/DOID:2256", "evidence": [ { "id": "2256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2256" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and 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"evidence": [ { "id": "8398", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8398" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "transmembrane receptor protein serine/threonine kinase activity", "id": "GO:0004675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004675", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "activin receptor activity, type I", "id": "GO:0016361", "url": 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}, { "name": "germ-line stem cell population maintenance", "id": "GO:0030718", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030718", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "compound eye morphogenesis", "id": "GO:0001745", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001745", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "dorsal closure", "id": "GO:0007391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007391", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "open tracheal system development", "id": "GO:0007424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007424", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "anterior/posterior pattern specification, imaginal disc", "id": "GO:0007448", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007448", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "imaginal disc-derived wing morphogenesis", "id": "GO:0007476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007476", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "histoblast morphogenesis", "id": "GO:0007488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007488", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "spectrosome organization", "id": "GO:0030721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030721", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "genital disc development", "id": "GO:0035215", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035215", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "germ-line stem cell division", "id": "GO:0042078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042078", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "regulation of imaginal disc growth", "id": "GO:0045570", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045570", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "negative regulation of salivary gland boundary specification", "id": "GO:0045705", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045705", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "wing disc anterior/posterior pattern formation", "id": "GO:0048100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048100", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "anterior Malpighian tubule development", "id": "GO:0061327", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061327", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "cell elongation involved in imaginal disc-derived wing morphogenesis", "id": "GO:0090254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090254", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "cellular response to growth factor stimulus", "id": "GO:0071363", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071363", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "BMP signaling pathway", "id": "GO:0030509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030509", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "activin receptor signaling pathway", "id": "GO:0032924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032924", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "dorsal/ventral pattern formation", "id": "GO:0009953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009953", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "positive regulation of SMAD protein signal transduction", "id": "GO:0060391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060391", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "amnioserosa formation", "id": "GO:0007378", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007378", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "follicle cell of egg chamber development", "id": "GO:0030707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030707", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "wing disc pattern formation", "id": "GO:0035222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035222", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "R8 cell fate specification", "id": "GO:0045464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045464", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "imaginal disc fusion, thorax closure", "id": "GO:0046529", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046529", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "dorsal closure, amnioserosa morphology change", "id": "GO:0046664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046664", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" }, { "name": "positive regulation of muscle organ development", "id": "GO:0048636", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048636", "evidence": [ { "database": "UniProtKB", "id": "Q9VMT1", "url": "https://www.uniprot.org/uniprotkb/Q9VMT1" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VPD6-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VPD6", "url": "https://www.uniprot.org/uniprotkb/Q9VPD6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 201, "chemical_mass": 22475.0, "gene_names": "BNIP3;BBH1;BNIP3;Bnip3;CG5059;Dmel\\CG5059;Dmel_CG5059", "protein_name": "", "disease": [ { "disease_id": "DOID:0060074", "name": "ductal carcinoma in situ", "description": "A breast carcinoma in situ that is characterized by being non-invasive, not having spread outside of the duct into the surrounding breast tissue, has_material_basis_in abnormally proliferating cells, derives_from epithelial cells.", "url": "https://disease-ontology.org/term/DOID:0060074", "evidence": [ { "id": "0060074", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060074" } ], "weight": 0.0 }, { "disease_id": "DOID:0080547", "name": "metabolic dysfunction-associated steatohepatitis", "description": "A metabolic dysfunction-associated steatotic liver disease characterized by the presence of inflammation with hepatocyte injury such as ballooning, with or without fibrosis.", "url": "https://disease-ontology.org/term/DOID:0080547", "evidence": [ { "id": "0080547", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080547" } ], "weight": 0.0 }, { "disease_id": "DOID:11714", "name": "gestational diabetes", "description": "A diabetes mellitus that manifests during pregnancy.", "url": "https://disease-ontology.org/term/DOID:11714", "evidence": [ { "id": "11714", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11714" } ], "weight": 0.0 }, { "disease_id": "DOID:224", "name": "transient cerebral ischemia", "description": "A brain ischemia that is characterized by ischemia of brief duration and without resultant tissue death.", "url": "https://disease-ontology.org/term/DOID:224", "evidence": [ { "id": "224", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:224" } ], "weight": 0.0 }, { "disease_id": "DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:3525", "name": "middle cerebral artery infarction", "description": "", "url": "https://disease-ontology.org/term/DOID:3525", "evidence": [ { "id": "3525", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3525" } ], "weight": 0.0 }, { "disease_id": "DOID:4989", "name": "pancreatitis", "description": "A pancreas disease that is characterized by inflammation of the pancreas.", "url": "https://disease-ontology.org/term/DOID:4989", "evidence": [ { "id": "4989", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4989" } ], "weight": 0.0 }, { "disease_id": "DOID:5327", "name": "retinal detachment", "description": "", "url": "https://disease-ontology.org/term/DOID:5327", "evidence": [ { "id": "5327", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5327" } ], "weight": 0.0 }, { "disease_id": "DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.", "url": "https://disease-ontology.org/term/DOID:5844", "evidence": [ { "id": "5844", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ], "weight": 0.0 }, { "disease_id": "DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.", "url": "https://disease-ontology.org/term/DOID:6000", "evidence": [ { "id": "6000", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ], "weight": 0.0 }, { "disease_id": "DOID:783", "name": "end stage renal disease", "description": "A chronic kidney disease is characterized by non-functioning kidneys, as the final stage in chronic kidney disease.", "url": "https://disease-ontology.org/term/DOID:783", "evidence": [ { "id": "783", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:783" } ], "weight": 0.0 }, { "disease_id": "DOID:8677", "name": "perinatal necrotizing enterocolitis", "description": "", "url": "https://disease-ontology.org/term/DOID:8677", "evidence": [ { "id": "8677", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8677" } ], "weight": 0.0 }, { "disease_id": "DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.", "url": "https://disease-ontology.org/term/DOID:9970", "evidence": [ { "id": "9970", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9970" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9VPD6", "url": "https://www.uniprot.org/uniprotkb/Q9VPD6" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "Q9VPD6", "url": "https://www.uniprot.org/uniprotkb/Q9VPD6" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "Q9VPD6", "url": "https://www.uniprot.org/uniprotkb/Q9VPD6" } ], "pmid": "" } ], "molecular_function": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q9VPD6", "url": "https://www.uniprot.org/uniprotkb/Q9VPD6" } ], "pmid": "" }, { "name": "mitochondrion autophagosome adaptor activity", "id": "GO:0140580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140580", "evidence": [ { "database": "UniProtKB", "id": "Q9VPD6", "url": "https://www.uniprot.org/uniprotkb/Q9VPD6" } ], "pmid": "" } ], "biological_process": [ { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "Q9VPD6", "url": "https://www.uniprot.org/uniprotkb/Q9VPD6" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q9VPD6", "url": "https://www.uniprot.org/uniprotkb/Q9VPD6" } ], "pmid": "" }, { "name": "mitophagy", "id": "GO:0000423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000423", "evidence": [ { "database": "UniProtKB", "id": "Q9VPD6", "url": "https://www.uniprot.org/uniprotkb/Q9VPD6" } ], "pmid": "" }, { "name": "regulation of programmed cell death", "id": "GO:0043067", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043067", "evidence": [ { "database": "UniProtKB", "id": "Q9VPD6", "url": "https://www.uniprot.org/uniprotkb/Q9VPD6" } ], "pmid": "" }, { "name": "mitochondrial outer membrane permeabilization", "id": "GO:0097345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097345", "evidence": [ { "database": "UniProtKB", "id": "Q9VPD6", "url": "https://www.uniprot.org/uniprotkb/Q9VPD6" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VW94-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VW94", "url": "https://www.uniprot.org/uniprotkb/Q9VW94" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 363, "chemical_mass": 38544.0, "gene_names": "Dmel\\CG6933;CG6933;Dmel\\CG6933;Dmel_CG6933", "protein_name": "Chitin-binding type-2 domain-containing protein", "disease": [], "cellular_component": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q9VW94", "url": "https://www.uniprot.org/uniprotkb/Q9VW94" } ], "pmid": "" }, { "name": "external encapsulating structure", "id": "GO:0030312", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030312", "evidence": [ { "database": "UniProtKB", "id": "Q9VW94", "url": "https://www.uniprot.org/uniprotkb/Q9VW94" } ], "pmid": "" } ], "molecular_function": [ { "name": "chitin binding", "id": "GO:0008061", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008061", "evidence": [ { "database": "UniProtKB", "id": "Q9VW94", "url": "https://www.uniprot.org/uniprotkb/Q9VW94" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9W330-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9W330", "url": "https://www.uniprot.org/uniprotkb/Q9W330" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 541, "chemical_mass": 59229.0, "gene_names": "Hex-A;B;CG3001;DM1;Dmel\\CG3001;Dmel_CG3001;HEX-A;HEX;HK-A;HK;Hex-A:B;Hex-A;HexA;Hex;hexokinase", "protein_name": "Phosphotransferase", "disease": [ { "disease_id": "DOID:0050524", "name": "maturity-onset diabetes of the young", "description": "A diabetes mellitus that has_material_basis_in autosomal dominant inheritance of mutations in the MODY genes impacting beta-cell function, typically occurring before 25 years of age and caused by primary insulin secretion defects.", "url": "https://disease-ontology.org/term/DOID:0050524", "evidence": [ { "id": "0050524", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050524" } ], "weight": 0.0 }, { "disease_id": "DOID:0051006", "name": "congenital nonspherocytic hemolytic anemia 5", "description": "A congenital nonspherocytic hemolytic anemia that has_material_basis_in homozygous or compound heterozygous mutation in the HK1 gene, which encodes a form of hexokinase, on chromosome 10q22.", "url": "https://disease-ontology.org/term/DOID:0051006", "evidence": [ { "id": "0051006", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0051006" } ], "weight": 0.0 }, { "disease_id": "DOID:0060639", "name": "permanent neonatal diabetes mellitus", "description": "A neonatal diabetes that has_material_basis_in homozygous mutation in the glucokinase gene (GCK), heterozygous mutation in the KCNJ11 and INS genes, or by heterozygous or homozygous mutation in the ABCC8 gene.", "url": "https://disease-ontology.org/term/DOID:0060639", "evidence": [ { "id": "0060639", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060639" } ], "weight": 0.0 }, { "disease_id": "DOID:0061107", "name": "retinitis pigmentosa 92", "description": "A retinitis pigmentosa characterized by relatively mild disease, with onset of night blindness and vision loss in the third to sixth decades of life that has_material_basis_in homozygous mutation in the HKDC1 gene on chromosome 10q22.", "url": "https://disease-ontology.org/term/DOID:0061107", "evidence": [ { "id": "0061107", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0061107" } ], "weight": 0.0 }, { "disease_id": "DOID:0061108", "name": "retinitis pigmentosa 79", "description": "A retinitis pigmentosa that has_material_basis_in heterozygous mutation in the HK1 gene on chromosome 10q22.", "url": "https://disease-ontology.org/term/DOID:0061108", "evidence": [ { "id": "0061108", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0061108" } ], "weight": 0.0 }, { "disease_id": "DOID:0070216", "name": "familial hyperinsulinemic hypoglycemia 3", "description": "A hyperinsulinemic hypoglycemia characterized by autosomal dominant inheritance of a reduced threshold for insulin release and hypoglycemia induced by fasting or protein rich meals that has_material_basis_in activating mutations in the GCK gene on chromosome 7p13.", "url": "https://disease-ontology.org/term/DOID:0070216", "evidence": [ { "id": "0070216", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070216" } ], "weight": 0.0 }, { "disease_id": "DOID:0110196", "name": "Charcot-Marie-Tooth disease type 4G", "description": "A Charcot-Marie-Tooth disease type 4 that has_material_basis_in homozygous mutation in the HK1 gene on chromosome 10q22.", "url": "https://disease-ontology.org/term/DOID:0110196", "evidence": [ { "id": "0110196", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110196" } ], "weight": 0.0 }, { "disease_id": "DOID:0111100", "name": "maturity-onset diabetes of the young type 2", "description": "A maturity-onset diabetes of the young that has_material_basis_in heterozygous mutation in the GCK gene on chromosome 7p13.", "url": "https://disease-ontology.org/term/DOID:0111100", "evidence": [ { "id": "0111100", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111100" } ], "weight": 0.0 }, { "disease_id": "DOID:10584", "name": "retinitis pigmentosa", "description": "A retinal degeneration characterized by the gradual deterioration of the photoreceptors or the retinal pigment epithelium of the retina leading to progressive sight loss.", "url": "https://disease-ontology.org/term/DOID:10584", "evidence": [ { "id": "10584", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10584" } ], "weight": 0.0 }, { "disease_id": "DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries.", "url": "https://disease-ontology.org/term/DOID:10763", "evidence": [ { "id": "10763", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ], "weight": 0.0 }, { "disease_id": "DOID:10923", "name": "sickle cell anemia", "description": "A sickle cell disease that is characterized by the replacement of both of the beta-globin subunits in hemoglobin with hemoglobin S, resulting in a low number of red blood cells, repeated infections, and periodic episodes of pain.", "url": "https://disease-ontology.org/term/DOID:10923", "evidence": [ { "id": "10923", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10923" } ], "weight": 0.0 }, { "disease_id": "DOID:11714", "name": "gestational diabetes", "description": "A diabetes mellitus that manifests during pregnancy.", "url": "https://disease-ontology.org/term/DOID:11714", "evidence": [ { "id": "11714", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11714" } ], "weight": 0.0 }, { "disease_id": "DOID:11717", "name": "neonatal diabetes mellitus", "description": "A diabetes mellitus that is characterized by hyperglycemia occurring within the first 6 months of life.", "url": "https://disease-ontology.org/term/DOID:11717", "evidence": [ { "id": "11717", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11717" } ], "weight": 0.0 }, { "disease_id": "DOID:13317", "name": "hyperinsulinemic hypoglycemia", "description": "A carbohydrate metabolic disorder that involves low blood glucose resulting from an excess of insulin.", "url": "https://disease-ontology.org/term/DOID:13317", "evidence": [ { "id": "13317", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13317" 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"uniprot_canonical_ac": "Q9VJR4-1", "start_pos": "465", "end_pos": "465", "site_lbl": "Thr465", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 465, "start_aa": "Thr", "end_pos": 465, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr465", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ] } ], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VKZ5-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VKZ5", "url": "https://www.uniprot.org/uniprotkb/Q9VKZ5" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 399, "chemical_mass": 43654.0, "gene_names": "Dmel\\CG4995;CG18626;CG4995;Dmel\\CG4995;Dmel_CG4995", "protein_name": "Mitochondrial basic amino acids transporter", "disease": [], "cellular_component": [ { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "Q9VKZ5", "url": "https://www.uniprot.org/uniprotkb/Q9VKZ5" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q9VKZ5", "url": "https://www.uniprot.org/uniprotkb/Q9VKZ5" } ], "pmid": "" } ], "biological_process": [ { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "Q9VKZ5", "url": "https://www.uniprot.org/uniprotkb/Q9VKZ5" } ], "pmid": "" }, { "name": "mitochondrial L-ornithine transmembrane transport", "id": "GO:1990575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990575", "evidence": [ { "database": "UniProtKB", "id": "Q9VKZ5", "url": "https://www.uniprot.org/uniprotkb/Q9VKZ5" } ], "pmid": "" } ], "molecular_function": [ { "name": "high-affinity L-arginine transmembrane transporter activity", "id": "GO:0005289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005289", "evidence": [ { "database": "UniProtKB", "id": "Q9VKZ5", "url": "https://www.uniprot.org/uniprotkb/Q9VKZ5" } ], "pmid": "" }, { "name": "high-affinity lysine transmembrane transporter activity", "id": "GO:0005292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005292", "evidence": [ { "database": "UniProtKB", "id": "Q9VKZ5", "url": "https://www.uniprot.org/uniprotkb/Q9VKZ5" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9W4Y0-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9W4Y0", "url": "https://www.uniprot.org/uniprotkb/Q9W4Y0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 240, "chemical_mass": 28028.0, "gene_names": "Dmel\\CG13760;EG:BACR25B3.6;CG13760;Dmel\\CG13760;Dmel_CG13760;EG:BACR25B3.6", "protein_name": "Protein GUCD1", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VX67-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VX67", "url": "https://www.uniprot.org/uniprotkb/Q9VX67" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 172, "chemical_mass": 14627.0, "gene_names": "CT16557;Dmel\\CG5172;BcDNA:RH06401;CG5172;CT16557;Dmel\\CG5172;Dmel_CG5172", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VYD9-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VYD9", "url": "https://www.uniprot.org/uniprotkb/Q9VYD9" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 575, "chemical_mass": 64047.0, "gene_names": "Alat;ALT;CG1640;Dmel\\CG1640;Dmel_CG1640;cg1640", "protein_name": "alanine transaminase", "disease": [ { "disease_id": "DOID:0070542", "name": "neurodevelopmental disorder with spastic paraplegia and microcephaly", "description": "An amino acid metabolic disorder characterized delayed psychomotor development with delayed walking, moderately to severely impaired intellectual development, and poor or absent speech that has_material_basis_in homozygous or compound heterozygous mutation in the GPT2 gene on chromosome 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The five cardiometabolic risk factors are: (1) higher than normal body mass index or waist circumference; (2) higher than normal serum glucose or glycated hemoglobin level, or type 2 diabetes; (3) higher than normal blood pressure or hypertensive treatment; (4) higher than normal plasma triglycerides or lipid lowering treatment; and (5) lower than normal plasma high-density lipoprotein cholesterol.", "url": "https://disease-ontology.org/term/DOID:0080208", "evidence": [ { "id": "0080208", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080208" } ], "weight": 0.0 }, { "disease_id": "DOID:13603", "name": "obstructive jaundice", "description": "A cholestasis characterized by yellowish pigmentation of the skin and sclera due to high bilirubin levels resulting from biliary tract obstruction.", "url": "https://disease-ontology.org/term/DOID:13603", "evidence": [ { "id": "13603", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13603" } ], "weight": 0.0 }, { "disease_id": "DOID:3021", "name": "acute kidney failure", "description": "", "url": "https://disease-ontology.org/term/DOID:3021", "evidence": [ { "id": "3021", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3021" } ], "weight": 0.0 }, { "disease_id": "DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver.", "url": "https://disease-ontology.org/term/DOID:3571", "evidence": [ { "id": "3571", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3571" } ], "weight": 0.0 }, { "disease_id": "DOID:5082", "name": "liver cirrhosis", "description": "", "url": "https://disease-ontology.org/term/DOID:5082", "evidence": [ { "id": "5082", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5082" } ], "weight": 0.0 }, { "disease_id": "DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.", "url": "https://disease-ontology.org/term/DOID:5844", "evidence": [ { "id": "5844", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ], "weight": 0.0 }, { "disease_id": "DOID:9252", "name": "amino acid metabolic disorder", "description": "An inherited metabolic disorder that is characterized by impaired synthesis and degradation of amino acids.", "url": "https://disease-ontology.org/term/DOID:9252", "evidence": [ { "id": "9252", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9252" } ], "weight": 0.0 }, { "disease_id": "DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.", "url": "https://disease-ontology.org/term/DOID:9352", "evidence": [ { "id": "9352", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ], "weight": 0.0 }, { "disease_id": "DOID:9452", "name": "steatotic liver disease", "description": "A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in at least 5% of hepatocytes.", "url": "https://disease-ontology.org/term/DOID:9452", "evidence": [ { "id": "9452", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9452" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q9VYD9", "url": "https://www.uniprot.org/uniprotkb/Q9VYD9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q9VYD9", "url": "https://www.uniprot.org/uniprotkb/Q9VYD9" } ], "pmid": "" }, { "name": "major mitochondrial derivative", "id": "GO:0016008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016008", "evidence": [ { "database": "UniProtKB", "id": "Q9VYD9", "url": "https://www.uniprot.org/uniprotkb/Q9VYD9" } ], "pmid": "" } ], "molecular_function": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "Q9VYD9", "url": "https://www.uniprot.org/uniprotkb/Q9VYD9" } ], "pmid": "" }, { "name": "L-alanine:2-oxoglutarate aminotransferase activity", "id": "GO:0004021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004021", "evidence": [ { "database": "UniProtKB", "id": "Q9VYD9", "url": "https://www.uniprot.org/uniprotkb/Q9VYD9" } ], "pmid": "" } ], "biological_process": [ { "name": "L-alanine catabolic process", "id": "GO:0042853", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042853", "evidence": [ { "database": "UniProtKB", "id": "Q9VYD9", "url": "https://www.uniprot.org/uniprotkb/Q9VYD9" } ], "pmid": "" }, { "name": "2-oxoglutarate metabolic process", "id": "GO:0006103", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006103", "evidence": [ { "database": "UniProtKB", "id": "Q9VYD9", "url": "https://www.uniprot.org/uniprotkb/Q9VYD9" } ], "pmid": "" }, { "name": "L-alanine metabolic process", "id": "GO:0042851", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042851", "evidence": [ { "database": "UniProtKB", "id": "Q9VYD9", "url": "https://www.uniprot.org/uniprotkb/Q9VYD9" } ], "pmid": "" }, { "name": "positive regulation of gluconeogenesis", "id": "GO:0045722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045722", "evidence": [ { "database": "UniProtKB", "id": "Q9VYD9", "url": "https://www.uniprot.org/uniprotkb/Q9VYD9" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VID4-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VID4", "url": "https://www.uniprot.org/uniprotkb/Q9VID4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 1119, "chemical_mass": 125235.0, "gene_names": "Mondo;154826_at;CG18362;ChREBP;Dmel\\CG18362;Dmel_CG18362;Mio;Mondo-Mlx;Mondo;anon-39Da;bHLHd12;dmondo;mio;mlx;mondo", "protein_name": "", "disease": [ { "disease_id": "DOID:0080208", "name": "metabolic dysfunction-associated steatotic liver disease", "description": "A steatotic liver disease characterized by at least one of five specified cardiometabolic risk factors and no other discernible cause with normal to no alcohol use. The five cardiometabolic risk factors are: (1) higher than normal body mass index or waist circumference; (2) higher than normal serum glucose or glycated hemoglobin level, or type 2 diabetes; (3) higher than normal blood pressure or hypertensive treatment; (4) higher than normal plasma triglycerides or lipid lowering treatment; and (5) lower than normal plasma high-density lipoprotein cholesterol.", "url": "https://disease-ontology.org/term/DOID:0080208", "evidence": [ { "id": "0080208", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080208" } ], "weight": 0.0 }, { "disease_id": "DOID:0080547", "name": "metabolic dysfunction-associated steatohepatitis", "description": "A metabolic dysfunction-associated steatotic liver disease characterized by the presence of inflammation with hepatocyte injury such as ballooning, with or without fibrosis.", "url": "https://disease-ontology.org/term/DOID:0080547", "evidence": [ { "id": "0080547", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080547" } ], "weight": 0.0 }, { "disease_id": "DOID:1574", "name": "alcohol use disorder", "description": "A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.", "url": "https://disease-ontology.org/term/DOID:1574", "evidence": [ { "id": "1574", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1574" } ], "weight": 0.0 }, { "disease_id": "DOID:3393", "name": "coronary artery disease", "description": "An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.", "url": "https://disease-ontology.org/term/DOID:3393", "evidence": [ { "id": "3393", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3393" } ], "weight": 0.0 }, { "disease_id": "DOID:557", "name": "kidney disease", "description": "A urinary system disease that is located_in the kidney.", "url": "https://disease-ontology.org/term/DOID:557", "evidence": [ { "id": "557", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:557" } ], "weight": 0.0 }, { "disease_id": "DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.", "url": "https://disease-ontology.org/term/DOID:5844", "evidence": [ { "id": "5844", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ], "weight": 0.0 }, { "disease_id": "DOID:783", "name": "end stage renal disease", "description": "A chronic kidney disease is characterized by non-functioning kidneys, as the final stage in chronic kidney disease.", "url": "https://disease-ontology.org/term/DOID:783", "evidence": [ { "id": "783", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:783" } ], "weight": 0.0 }, { "disease_id": "DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.", "url": "https://disease-ontology.org/term/DOID:9352", "evidence": [ { "id": "9352", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ], "weight": 0.0 }, { "disease_id": "DOID:9778", "name": "irritable bowel syndrome", "description": "An intestinal disease that is characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause.", "url": "https://disease-ontology.org/term/DOID:9778", "evidence": [ { "id": "9778", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9778" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q9VID4", "url": "https://www.uniprot.org/uniprotkb/Q9VID4" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "Q9VID4", "url": "https://www.uniprot.org/uniprotkb/Q9VID4" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q9VID4", "url": "https://www.uniprot.org/uniprotkb/Q9VID4" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q9VID4", "url": "https://www.uniprot.org/uniprotkb/Q9VID4" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": 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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q9VID4", "url": "https://www.uniprot.org/uniprotkb/Q9VID4" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "Q9VID4", "url": "https://www.uniprot.org/uniprotkb/Q9VID4" } ], "pmid": "" }, { "name": "glucose homeostasis", "id": "GO:0042593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593", "evidence": [ { "database": "UniProtKB", "id": "Q9VID4", "url": "https://www.uniprot.org/uniprotkb/Q9VID4" } ], "pmid": "" }, { "name": "triglyceride homeostasis", "id": "GO:0070328", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070328", "evidence": [ { "database": "UniProtKB", "id": "Q9VID4", "url": "https://www.uniprot.org/uniprotkb/Q9VID4" } ], "pmid": "" }, { "name": "response to sucrose", "id": "GO:0009744", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "Q9VHX2", "url": "https://www.uniprot.org/uniprotkb/Q9VHX2" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VHX4-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VHX4", "url": "https://www.uniprot.org/uniprotkb/Q9VHX4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 329, "chemical_mass": 36862.0, "gene_names": "Ar5;CG2767;Dmel\\CG2767;Dmel_CG2767", "protein_name": "NADP-dependent oxidoreductase domain-containing protein", "disease": [], "cellular_component": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q9VHX4", "url": 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"" }, { "name": "glutathione import into mitochondrion", "id": "GO:0160007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160007", "evidence": [ { "database": "UniProtKB", "id": "Q9VI05", "url": "https://www.uniprot.org/uniprotkb/Q9VI05" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VI07-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VI07", "url": "https://www.uniprot.org/uniprotkb/Q9VI07" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 280, "chemical_mass": 30234.0, "gene_names": "Osi20;CG15188;Dmel\\CG15188;Dmel_CG15188;Osi20", "protein_name": "", "disease": [], "cellular_component": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9VI07", "url": "https://www.uniprot.org/uniprotkb/Q9VI07" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q9VI07", "url": "https://www.uniprot.org/uniprotkb/Q9VI07" } ], "pmid": "" } ], "biological_process": [ { "name": "open tracheal system development", "id": "GO:0007424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007424", "evidence": [ { "database": "UniProtKB", "id": "Q9VI07", "url": "https://www.uniprot.org/uniprotkb/Q9VI07" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VI24-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VI24", "url": "https://www.uniprot.org/uniprotkb/Q9VI24" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], 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maintenance of neuroblast polarity", "id": "GO:0045196", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045196", "evidence": [ { "database": "UniProtKB", "id": "Q9VI24", "url": "https://www.uniprot.org/uniprotkb/Q9VI24" } ], "pmid": "" } ], "molecular_function": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q9VI24", "url": "https://www.uniprot.org/uniprotkb/Q9VI24" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "Q9VI24", "url": "https://www.uniprot.org/uniprotkb/Q9VI24" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q9VI24", "url": "https://www.uniprot.org/uniprotkb/Q9VI24" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q9VI24", "url": "https://www.uniprot.org/uniprotkb/Q9VI24" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "Q9VI24", "url": "https://www.uniprot.org/uniprotkb/Q9VI24" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q9VI24", "url": "https://www.uniprot.org/uniprotkb/Q9VI24" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "Q9VI24", "url": "https://www.uniprot.org/uniprotkb/Q9VI24" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9VI24", "url": "https://www.uniprot.org/uniprotkb/Q9VI24" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VI51-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VI51", "url": "https://www.uniprot.org/uniprotkb/Q9VI51" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 286, "chemical_mass": 33829.0, "gene_names": "djl;CG1984;DJL;Dmel\\CG1984;Dmel_CG1984;Don Juan-like;dj like;dj-like;djl", "protein_name": "", "disease": [], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": 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"Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 283, "chemical_mass": 31862.0, "gene_names": "NEST:bs33f03;CG2656;Dmel\\CG2656;Dmel_CG2656;NEST:bs33f03", "protein_name": "GPN-loop GTPase 3", "disease": [], "molecular_function": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "Q9VI70", "url": "https://www.uniprot.org/uniprotkb/Q9VI70" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q9VI70", "url": "https://www.uniprot.org/uniprotkb/Q9VI70" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VI85-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VI85", "url": 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"evidence": [ { "database": "UniProtKB", "id": "Q9VI85", "url": "https://www.uniprot.org/uniprotkb/Q9VI85" } ], "pmid": "" } ], "biological_process": [ { "name": "tRNA modification", "id": "GO:0006400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006400", "evidence": [ { "database": "UniProtKB", "id": "Q9VI85", "url": "https://www.uniprot.org/uniprotkb/Q9VI85" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VI98-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VI98", "url": "https://www.uniprot.org/uniprotkb/Q9VI98" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 200, "chemical_mass": 23290.0, "gene_names": "Dmel\\CG17944;CG17944;Dmel\\CG17944;Dmel_CG17944", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VIC9-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VIC9", "url": "https://www.uniprot.org/uniprotkb/Q9VIC9" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 913, "chemical_mass": 100298.0, "gene_names": "Dmel\\CG8665;CG8665;Dmel\\CG8665;Dmel_CG8665", "protein_name": "10-formyltetrahydrofolate dehydrogenase", "disease": [ { "disease_id": "DOID:0080208", "name": "metabolic dysfunction-associated steatotic liver disease", "description": "A steatotic liver disease characterized by at least one of five specified cardiometabolic risk factors and no other discernible cause with normal to no alcohol use. The five cardiometabolic risk factors are: (1) higher than normal body mass index or waist circumference; (2) higher than normal serum glucose or glycated hemoglobin level, or type 2 diabetes; (3) higher than normal blood pressure or hypertensive treatment; (4) higher than normal plasma triglycerides or lipid lowering treatment; and (5) lower than normal plasma high-density lipoprotein cholesterol.", "url": "https://disease-ontology.org/term/DOID:0080208", "evidence": [ { "id": "0080208", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080208" } ], "weight": 0.0 }, { "disease_id": "DOID:13580", "name": "cholestasis", "description": "A bile duct disease that is characterized by where bile cannot flow from the liver to the duodenum.", "url": "https://disease-ontology.org/term/DOID:13580", "evidence": [ { "id": "13580", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13580" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q9VIC9", "url": "https://www.uniprot.org/uniprotkb/Q9VIC9" } ], "pmid": "" } ], "molecular_function": [ { "name": "aldehyde dehydrogenase (NAD+) activity", "id": "GO:0004029", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004029", "evidence": [ { "database": "UniProtKB", "id": "Q9VIC9", "url": "https://www.uniprot.org/uniprotkb/Q9VIC9" } ], "pmid": "" }, { "name": "transferase activity", "id": "GO:0016740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016740", "evidence": [ { "database": "UniProtKB", "id": "Q9VIC9", "url": "https://www.uniprot.org/uniprotkb/Q9VIC9" } ], "pmid": "" }, { "name": "formyltetrahydrofolate dehydrogenase activity", "id": "GO:0016155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016155", "evidence": [ { "database": "UniProtKB", "id": "Q9VIC9", "url": "https://www.uniprot.org/uniprotkb/Q9VIC9" } ], "pmid": "" } ], 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"circadian rhythm", "id": "GO:0007623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007623", "evidence": [ { "database": "UniProtKB", "id": "Q9VK11", "url": "https://www.uniprot.org/uniprotkb/Q9VK11" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VK19-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VK19", "url": "https://www.uniprot.org/uniprotkb/Q9VK19" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 246, "chemical_mass": 27022.0, "gene_names": "Ski6;CG15481;Dmel\\CG15481;Dmel_CG15481;Rrp41;Ski6;dRrp41;dSki6", "protein_name": "", "disease": [ { "disease_id": "DOID:0060037", "name": "developmental disorder of mental health", "description": "A disease of mental health that occur during a child's developmental period between birth and age 18 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"biological_process": [ { "name": "negative regulation of ERK1 and ERK2 cascade", "id": "GO:0070373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070373", "evidence": [ { "database": "UniProtKB", "id": "Q9VK60", "url": "https://www.uniprot.org/uniprotkb/Q9VK60" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VK64-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VK64", "url": "https://www.uniprot.org/uniprotkb/Q9VK64" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 432, "chemical_mass": 47776.0, "gene_names": "Dmel\\CG17036;CG17036;Dmel\\CG17036;Dmel_CG17036", "protein_name": "Thiamine transporter 1", "disease": [ { "disease_id": "DOID:0050659", "name": "biotin-responsive basal ganglia disease", "description": "A basal ganglia disease that is 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"Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 408, "chemical_mass": 46190.0, "gene_names": "Wdfy2;CG5168;Dmel\\CG5168;Dmel_CG5168;WDFY2;Wdfy2", "protein_name": "", "disease": [], "cellular_component": [ { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "Q9VKW1", "url": "https://www.uniprot.org/uniprotkb/Q9VKW1" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "Q9VKW1", "url": "https://www.uniprot.org/uniprotkb/Q9VKW1" } ], "pmid": "" } ], "molecular_function": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q9VKW1", "url": "https://www.uniprot.org/uniprotkb/Q9VKW1" } ], "pmid": "" }, { "name": "protein 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"l(2)SH0834;CG5385;Dmel\\CG5385;Dmel_CG5385;l(2)SH0834;l(2)SH2 0834", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.fruitfly.12" }, { "uniprot_canonical_ac": "Q9VL10-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VL10", "url": "https://www.uniprot.org/uniprotkb/Q9VL10" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 408, "chemical_mass": 45715.0, "gene_names": "Mulk;CG18162;CG31873;Dmel\\CG31873;Dmel_CG31873;Dmulk;Mulk;anon-31BCb", "protein_name": "Acylglycerol kinase, mitochondrial", "disease": [ { "disease_id": "DOID:0080132", "name": "Sengers syndrome", "description": "A mitochondrial DNA depletion syndrome that is characterized by congenital cataracts, hypertrophic cardiomyopathy, skeletal myopathy, exercise intolerance, and lactic acidosis, but normal mental 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"name": "germ cell migration", "id": "GO:0008354", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008354", "evidence": [ { "database": "UniProtKB", "id": "Q9VL10", "url": "https://www.uniprot.org/uniprotkb/Q9VL10" } ], "pmid": "" }, { "name": "glycerolipid metabolic process", "id": "GO:0046486", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046486", "evidence": [ { "database": "UniProtKB", "id": "Q9VL10", "url": "https://www.uniprot.org/uniprotkb/Q9VL10" } ], "pmid": "" } ], "molecular_function": [ { "name": "ceramide kinase activity", "id": "GO:0001729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001729", "evidence": [ { "database": "UniProtKB", "id": "Q9VL10", "url": "https://www.uniprot.org/uniprotkb/Q9VL10" } ], "pmid": "" }, { "name": "ATP-dependent diacylglycerol kinase activity", "id": "GO:0004143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004143", "evidence": [ { "database": "UniProtKB", "id": "Q9VL10", "url": "https://www.uniprot.org/uniprotkb/Q9VL10" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q9VL10", "url": "https://www.uniprot.org/uniprotkb/Q9VL10" } ], "pmid": "" }, { "name": "acylglycerol kinase activity", "id": "GO:0047620", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047620", "evidence": [ { "database": "UniProtKB", "id": "Q9VL10", "url": "https://www.uniprot.org/uniprotkb/Q9VL10" } ], "pmid": "" } ], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9VL10", "url": "https://www.uniprot.org/uniprotkb/Q9VL10" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q9VL10", "url": "https://www.uniprot.org/uniprotkb/Q9VL10" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", 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