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Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 149, "start_aa": "Asn", "end_pos": 149, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn149", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" }, { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "10.1101/2020.03.28.013276", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2020.03.28.013276" } ] }, { "glytoucan_ac": "G60145BJ", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 149, "start_aa": "Asn", "end_pos": 149, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn149", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G62765YT", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Identified intact N-glycopeptides with noted commentS-T-after-R1", "icn3d_view": {}, "start_pos": 149, "start_aa": "Asn", "end_pos": 149, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn149", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1074/mcp.RA120.002295", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.RA120.002295" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" }, { "id": "10.1101/2020.03.28.013276", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2020.03.28.013276" } ] }, { "glytoucan_ac": "G62792OG", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "S2P-AC", "icn3d_view": {}, "start_pos": 149, "start_aa": "Asn", "end_pos": 149, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn149", "evidence": [ { "id": "33064451", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33064451" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1021/acs.analchem.0c03301", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1021/acs.analchem.0c03301" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" }, { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "10.1101/2020.03.28.013276", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2020.03.28.013276" } ] }, { "glytoucan_ac": "G64527OM", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 149, "start_aa": "Asn", "end_pos": 149, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn149", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G64615IX", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Identified intact N-glycopeptides before enrichment (trypsin digestion)", "icn3d_view": {}, "start_pos": 149, "start_aa": "Asn", "end_pos": 149, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn149", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1101/2020.03.28.013276", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2020.03.28.013276" } ] }, { "glytoucan_ac": "G65184UU", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Identified intact N-glycopeptides before enrichment (trypsin digestion)", "icn3d_view": {}, "start_pos": 149, "start_aa": "Asn", "end_pos": 149, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn149", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1101/2020.03.28.013276", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2020.03.28.013276" } ] }, { "glytoucan_ac": "G67367OT", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Identified intact N-glycopeptides before enrichment (trypsin digestion)", "icn3d_view": {}, "start_pos": 149, "start_aa": "Asn", "end_pos": 149, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn149", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1101/2020.03.28.013276", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2020.03.28.013276" } ] }, { "glytoucan_ac": "G68318VE", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "S1-AC", "icn3d_view": {}, "start_pos": 149, "start_aa": "Asn", "end_pos": 149, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn149", "evidence": [ { "id": "33064451", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33064451" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1021/acs.analchem.0c03301", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1021/acs.analchem.0c03301" }, { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" }, { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "10.1101/2020.03.28.013276", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2020.03.28.013276" } ] }, { "glytoucan_ac": "G69107AL", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Biological Replicate 3", "icn3d_view": {}, "start_pos": 149, "start_aa": "Asn", "end_pos": 149, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn149", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" } ] }, { "glytoucan_ac": "G69364JQ", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Identified intact N-glycopeptides before enrichment (trypsin digestion)", "icn3d_view": {}, "start_pos": 149, "start_aa": "Asn", "end_pos": 149, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn149", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1101/2020.03.28.013276", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2020.03.28.013276" } ] }, { "glytoucan_ac": "G70087PV", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Biological Replicate 1", "icn3d_view": {}, "start_pos": 149, "start_aa": "Asn", "end_pos": 149, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn149", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": 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"N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Identified intact N-glycopeptides before enrichment (trypsin digestion)", "icn3d_view": {}, "start_pos": 149, "start_aa": "Asn", "end_pos": 149, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn149", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1101/2020.03.28.013276", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2020.03.28.013276" } ] }, { "glytoucan_ac": "G73430PD", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": 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"glycosylation": [ { "glytoucan_ac": "G00031MO", "type": "O-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 678, "start_aa": "Thr", "end_pos": 678, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr678", "evidence": [ { "id": "33806155", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33806155" }, { "id": "2952", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2952" }, { "id": "2953", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2953" } ] }, { "glytoucan_ac": "G29931IJ", "type": "O-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 678, "start_aa": "Thr", "end_pos": 678, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr678", "evidence": [ { "id": "33806155", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33806155" }, { "id": "2952", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2952" }, { "id": "2953", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2953" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 678, "start_aa": "Thr", "end_pos": 678, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr678", "evidence": [ { "id": "33806155", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33806155" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.3390/v13040551", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.3390/v13040551" }, { "id": "2952", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2952" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true, "automatic_literature_mining": true }, "site_seq": "T", "relation": "attached", "comment": "O-linked (GlcNAc...) threonine;O-GlcNAcylation", "icn3d_view": {}, "start_pos": 678, "start_aa": "Thr", "end_pos": 678, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr678", "evidence": [ { "id": "P0DTC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0DTC2#ptm_processing" }, { "id": "34732583", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34732583" }, { "id": "33406838", "database": "PubMed", "url": 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"site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 679, "start_aa": "Asn", "end_pos": 679, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn679", "evidence": [ { "id": "35575289", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35575289" }, { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "mining_tool": "GlycoSiteMiner_1.0", "mining_tool_list": [ { "label": "GlycoSiteMiner_1.0" } ] } ] }, { "uniprot_canonical_ac": "P0DTC2-1", "start_pos": "703", "end_pos": "703", "site_lbl": "Asn703", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": { "label": "iCn3D", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?bcifid=7XIY&bu=0&command=select+.C:709;+center+selection;+zoom+selection" }, "start_pos": 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"glycosylation": [ { "glytoucan_ac": "G00406II", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "2839", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2839" } ] }, { "glytoucan_ac": "G02815KT", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "10.1074/mcp.RA120.002295", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.RA120.002295" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G05724UK", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "32363391", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32363391" }, { "id": "2838", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2838" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G06110VR", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "32363391", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32363391" }, { "id": "2838", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2838" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" }, { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "2839", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2839" } ] }, { "glytoucan_ac": "G08011QI", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "2839", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2839" } ] }, { "glytoucan_ac": "G08293MJ", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" } ] }, { "glytoucan_ac": "G10256JP", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G10339FR", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "10.1074/mcp.RA120.002295", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.RA120.002295" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G15486FH", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "10.1074/mcp.RA120.002295", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.RA120.002295" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G16407EV", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Identified intact N-glycopeptides with noted commentS-G-before-R1", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1074/mcp.RA120.002295", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.RA120.002295" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G20956ZV", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Glycan database GlycomeDB; gLabel embedded in pGlyco2.0; Byonic (N-glycan 38 insect database)", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" } ] }, { "glytoucan_ac": "G21726WW", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Identified intact N-glycopeptides with noted commentS-G-after-R2", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1074/mcp.RA120.002295", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.RA120.002295" } ] }, { "glytoucan_ac": "G22040QI", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" }, { "id": "2839", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2839" } ] }, { "glytoucan_ac": "G22768VO", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": { "label": "iCn3D", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?bcifid=8CYB&bu=0&command=select+.A:709;+center+selection;+zoom+selection" }, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "8CYB", "database": "PDB", "url": "https://www.rcsb.org/structure/8CYB" }, { "id": "8CYB", "database": "PDB", "url": "https://www.rcsb.org/structure/8CYB" }, { "id": "8CYB|A|709", "database": "", "url": "" } ] }, { "glytoucan_ac": "G23453IV", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G25637MV", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "2839", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2839" } ] }, { "glytoucan_ac": "G25987BV", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "10.1074/mcp.RA120.002295", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.RA120.002295" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G26759AS", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" }, { "id": "2839", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2839" } ] }, { "glytoucan_ac": "G27622TD", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Identified intact N-glycopeptides with noted commentS-G-after-R1", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1074/mcp.RA120.002295", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.RA120.002295" } ] }, { "glytoucan_ac": "G28541PG", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" } ] }, { "glytoucan_ac": "G28681TP", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Glycan database GlycomeDB; gLabel embedded in pGlyco2.0; Byonic (N-glycan 38 insect database)", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" } ] }, { "glytoucan_ac": "G28997IA", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Identified intact N-glycopeptides with noted commentS-G-after-R1", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1074/mcp.RA120.002295", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.RA120.002295" } ] }, { "glytoucan_ac": "G31852PQ", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "10.1074/mcp.RA120.002295", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.RA120.002295" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G32104JU", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "2839", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2839" } ] }, { "glytoucan_ac": "G35029YA", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Identified intact N-glycopeptides with noted commentS-G-before-R1", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1074/mcp.RA120.002295", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.RA120.002295" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G39188ZX", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "32363391", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32363391" }, { "id": "2838", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2838" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G39446WN", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G41247ZX", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "10.1074/mcp.RA120.002295", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.RA120.002295" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G44215PV", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" }, { "id": "2839", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2839" } ] }, { "glytoucan_ac": "G45504EY", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "SARS-CoV-2 S protein", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "32363391", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32363391" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1101/2020.04.01.020966", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2020.04.01.020966" } ] }, { "glytoucan_ac": "G46687AB", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G49874UX", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G53434XO", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Identified intact N-glycopeptides with noted commentS-G-after-R1", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1074/mcp.RA120.002295", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.RA120.002295" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G57317CE", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Identified intact N-glycopeptides with noted commentS-G-after-R2", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1074/mcp.RA120.002295", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.RA120.002295" } ] }, { "glytoucan_ac": "G57776ZU", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Identified intact N-glycopeptides with noted commentS-TG-before-R2", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1074/mcp.RA120.002295", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.RA120.002295" } ] }, { "glytoucan_ac": "G59937CP", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "S2P-LC", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "33064451", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33064451" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1021/acs.analchem.0c03301", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1021/acs.analchem.0c03301" }, { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" } ] }, { "glytoucan_ac": "G62765YT", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "10.1074/mcp.RA120.002295", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.RA120.002295" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G64527OM", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G66538GV", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G67324HN", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" } ] }, { "glytoucan_ac": "G68318VE", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" } ] }, { "glytoucan_ac": "G70101JE", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "2839", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2839" } ] }, { "glytoucan_ac": "G76613WN", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" }, { "id": "2839", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2839" } ] }, { "glytoucan_ac": "G80475RE", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Glycan database GlycomeDB; gLabel embedded in pGlyco2.0; Byonic (N-glycan 38 insect database)", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" } ] }, { "glytoucan_ac": "G80920RR", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "S2P-AC", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "33064451", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33064451" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1021/acs.analchem.0c03301", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1021/acs.analchem.0c03301" }, { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "10.1074/mcp.RA120.002295", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.RA120.002295" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G82364UA", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Identified intact N-glycopeptides with noted commentS-G-before-R1", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1074/mcp.RA120.002295", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.RA120.002295" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G83555HU", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "S2P-LC", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "33064451", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33064451" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1021/acs.analchem.0c03301", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1021/acs.analchem.0c03301" }, { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" } ] }, { "glytoucan_ac": "G88725PI", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" } ] }, { "glytoucan_ac": "G92050GC", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Identified intact N-glycopeptides with noted commentS-G-after-R1", "icn3d_view": {}, "start_pos": 709, "start_aa": "Asn", "end_pos": 709, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn709", "evidence": [ { "id": "33077685", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33077685" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1074/mcp.RA120.002295", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.RA120.002295" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": 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Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" } ] }, { "glytoucan_ac": "G10773YW", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G14260UH", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32363391", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32363391" }, { "id": "2838", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2838" } ] }, { "glytoucan_ac": "G14994KB", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G15486FH", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G16407EV", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Glycan database GlycomeDB; gLabel embedded in pGlyco2.0; Byonic (N-glycan 38 insect database)", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" } ] }, { "glytoucan_ac": "G20956ZV", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Glycan database GlycomeDB; gLabel embedded in pGlyco2.0; Byonic (N-glycan 38 insect database)", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" } ] }, { "glytoucan_ac": "G21643DJ", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G22573RC", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": { "label": "iCn3D", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?bcifid=9BBK&bu=0&command=select+.B:717;+center+selection;+zoom+selection" }, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "9BBK", "database": "PDB", "url": "https://www.rcsb.org/structure/9BBK" }, { "id": "9BBK", "database": "PDB", "url": "https://www.rcsb.org/structure/9BBK" }, { "id": "9BD9", "database": "PDB", "url": "https://www.rcsb.org/structure/9BD9" }, { "id": "9BD9", "database": "PDB", "url": "https://www.rcsb.org/structure/9BD9" }, { "id": "9BEA", "database": "PDB", "url": "https://www.rcsb.org/structure/9BEA" }, { "id": "9BEA", "database": "PDB", "url": "https://www.rcsb.org/structure/9BEA" }, { "id": "9BBK|B|717", "database": "", "url": "" }, { "id": "9BD9|B|717", "database": "", "url": "" }, { "id": "9BEA|C|717", "database": "", "url": "" } ] }, { "glytoucan_ac": "G22768VO", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": { "label": "iCn3D", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?bcifid=7TEI&bu=0&command=select+.C:717;+center+selection;+zoom+selection" }, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "7TEI", "database": "PDB", "url": "https://www.rcsb.org/structure/7TEI" }, { "id": "7TEI", "database": "PDB", "url": "https://www.rcsb.org/structure/7TEI" }, { "id": "7TF8", "database": "PDB", "url": "https://www.rcsb.org/structure/7TF8" }, { "id": "7TF8", "database": "PDB", "url": "https://www.rcsb.org/structure/7TF8" }, { "id": "7WUH", "database": "PDB", "url": "https://www.rcsb.org/structure/7WUH" }, { "id": "7WUH", "database": "PDB", "url": "https://www.rcsb.org/structure/7WUH" }, { "id": "8EPN", "database": "PDB", "url": "https://www.rcsb.org/structure/8EPN" }, { "id": "8EPN", "database": "PDB", "url": "https://www.rcsb.org/structure/8EPN" }, { "id": "8CYB", "database": "PDB", "url": "https://www.rcsb.org/structure/8CYB" }, { "id": "8CYB", "database": "PDB", "url": "https://www.rcsb.org/structure/8CYB" }, { "id": "9BEA", "database": "PDB", "url": "https://www.rcsb.org/structure/9BEA" }, { "id": "9BEA", "database": "PDB", "url": "https://www.rcsb.org/structure/9BEA" }, { "id": "7TEI|C|717", "database": "", "url": "" }, { "id": "7TEI|B|717", "database": "", "url": "" }, { "id": "7TEI|A|717", "database": "", "url": "" }, { "id": "7TF8|B|717", "database": "", "url": "" }, { "id": "7TF8|C|717", "database": "", "url": "" }, { "id": "7WUH|C|717", "database": "", "url": "" }, { "id": "8EPN|C|717", "database": "", "url": "" }, { "id": "8EPN|B|717", "database": "", "url": "" }, { "id": "8EPN|A|717", "database": "", "url": "" }, { "id": "8CYB|C|717", "database": "", "url": "" }, { "id": "8CYB|A|717", "database": "", "url": "" }, { "id": "9BEA|A|717", "database": "", "url": "" } ] }, { "glytoucan_ac": "G23294PN", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G23453IV", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G23863VK", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G25987BV", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Glycan database GlycomeDB; gLabel embedded in pGlyco2.0; Byonic (N-glycan 38 insect database)", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" } ] }, { "glytoucan_ac": "G28541PG", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" } ] }, { "glytoucan_ac": "G28681TP", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Glycan database GlycomeDB; gLabel embedded in pGlyco2.0; Byonic (N-glycan 38 insect database)", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" } ] }, { "glytoucan_ac": "G29880MM", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G30799SW", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" }, { "id": "2839", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2839" } ] }, { "glytoucan_ac": "G31852PQ", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G33609NS", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G34029GR", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Biological Replicate 3", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" } ] }, { "glytoucan_ac": "G35029YA", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Biological Replicate 1", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G37399XV", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" } ] }, { "glytoucan_ac": "G39188ZX", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32363391", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32363391" }, { "id": "2838", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2838" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G39446WN", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G41247ZX", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G46687AB", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G50045TK", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G50073PQ", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Biological Replicate 3", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" } ] }, { "glytoucan_ac": "G53434XO", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Glycan database GlycomeDB; gLabel embedded in pGlyco2.0; Byonic (N-glycan 38 insect database)", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" } ] }, { "glytoucan_ac": "G54600FO", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Biological Replicate 1", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" } ] }, { "glytoucan_ac": "G57776ZU", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" } ] }, { "glytoucan_ac": "G58802FE", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Biological Replicate 3", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" } ] }, { "glytoucan_ac": "G59937CP", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" } ] }, { "glytoucan_ac": "G60145BJ", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32363391", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32363391" }, { "id": "2838", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2838" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G60177UT", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G62765YT", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Glycan database GlycomeDB; gLabel embedded in pGlyco2.0; Byonic (N-glycan 38 insect database)", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" } ] }, { "glytoucan_ac": "G65184UU", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" } ] }, { "glytoucan_ac": "G66538GV", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G66766XF", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G67324HN", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" } ] }, { "glytoucan_ac": "G70101JE", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G72735IY", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G74430RZ", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G79568CQ", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G80475RE", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Biological Replicate 1", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G80920RR", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Biological Replicate 1", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" }, { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" } ] }, { "glytoucan_ac": "G81315DD", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": { "label": "iCn3D", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?bcifid=6ZOW&bu=0&command=select+.B:717;+center+selection;+zoom+selection" }, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "6ZOW", "database": "PDB", "url": "https://www.rcsb.org/structure/6ZOW" }, { "id": "6ZOW", "database": "PDB", "url": "https://www.rcsb.org/structure/6ZOW" }, { "id": "6ZP5", "database": "PDB", "url": "https://www.rcsb.org/structure/6ZP5" }, { "id": "6ZP5", "database": "PDB", "url": "https://www.rcsb.org/structure/6ZP5" }, { "id": "6ZP7", "database": "PDB", "url": "https://www.rcsb.org/structure/6ZP7" }, { "id": "6ZP7", "database": "PDB", "url": "https://www.rcsb.org/structure/6ZP7" }, { "id": "7TF8", "database": "PDB", "url": "https://www.rcsb.org/structure/7TF8" }, { "id": "7TF8", "database": "PDB", "url": "https://www.rcsb.org/structure/7TF8" }, { "id": "7TL1", "database": "PDB", "url": "https://www.rcsb.org/structure/7TL1" }, { "id": "7TL1", "database": "PDB", "url": "https://www.rcsb.org/structure/7TL1" }, { "id": "9B8F", "database": "PDB", "url": "https://www.rcsb.org/structure/9B8F" }, { "id": "9B8F", "database": "PDB", "url": "https://www.rcsb.org/structure/9B8F" }, { "id": "9B9U", "database": "PDB", "url": "https://www.rcsb.org/structure/9B9U" }, { "id": "9B9U", "database": "PDB", "url": "https://www.rcsb.org/structure/9B9U" }, { "id": "9BBK", "database": "PDB", "url": "https://www.rcsb.org/structure/9BBK" }, { "id": "9BBK", "database": "PDB", "url": "https://www.rcsb.org/structure/9BBK" }, { "id": "9BEA", "database": "PDB", "url": "https://www.rcsb.org/structure/9BEA" }, { "id": "9BEA", "database": "PDB", "url": "https://www.rcsb.org/structure/9BEA" }, { "id": "6ZOW|B|717", "database": "", "url": "" }, { "id": "6ZOW|A|717", "database": "", "url": "" }, { "id": "6ZP5|B|538", "database": "", "url": "" }, { "id": "6ZP5|A|690", "database": "", "url": "" }, { "id": "6ZP7|B|717", "database": "", "url": "" }, { "id": "6ZP7|A|717", "database": "", "url": "" }, { "id": "7TF8|A|717", "database": "", "url": "" }, { "id": "7TL1|A|717", "database": "", "url": "" }, { "id": "9B8F|C|717", "database": "", "url": "" }, { "id": "9B8F|A|717", "database": "", "url": "" }, { "id": "9B9U|B|717", "database": "", "url": "" }, { "id": "9BBK|C|717", "database": "", "url": "" }, { "id": "9BEA|B|717", "database": "", "url": "" } ] }, { "glytoucan_ac": "G82119TF", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32363391", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32363391" }, { "id": "2838", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2838" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G82364UA", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Glycan database GlycomeDB; gLabel embedded in pGlyco2.0; Byonic (N-glycan 38 insect database)", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" } ] }, { "glytoucan_ac": "G82463GQ", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G83555HU", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1126/science.abb9983" } ] }, { "glytoucan_ac": "G84452RH", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G84820NF", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "2840", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2840" } ] }, { "glytoucan_ac": "G86408JD", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "32518941", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32518941" }, { "id": "2839", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2839" } ] }, { "glytoucan_ac": "G92050GC", "type": "N-linked;o-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "Elastase digestion of purified S protein, providing glycopeptide identification metrics from Byonic search. Expression construct included residues 1\u22121208 of the SARS-CoV-2 S (GenBank: MN908947) with proline substitutions at residues 986 and 987, a \u201cGSAS\u201d substitution at the furin cleavage site (residues 682\u2013685), a C-terminal T4 fibritin trimerization motif, an HRV3C protease cleavage site, a TwinStrepTag and an 8XHisTag.", "icn3d_view": {}, "start_pos": 717, "start_aa": "Asn", "end_pos": 717, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn717", "evidence": [ { "id": "34004174", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34004174" }, { "id": "GLY_000479", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000479" }, { "id": "10.1016/j.celrep.2021.109179", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1016/j.celrep.2021.109179" }, { "id": "32366695", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32366695" }, { "id": "10.1126/science.abb9983", "database": "DOI", "url": 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is characterized by the inability to move the eyes in certain directions, droopy eyelids and eyes that are fixed in an abnormal position.", "url": "https://disease-ontology.org/term/DOID:0080143", "evidence": [ { "id": "0080143", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080143" } ], "weight": 0.0 }, { "disease_id": "DOID:0081017", "name": "congenital fibrosis of the extraocular muscles 3A", "description": "A congenital fibrosis of the extraocular muscles that is characterized by a variable phenotype where individuals may not have bilateral involvement, may be able to raise the eyes above midline, or may not have blepharoptosis and that has_material_basis_in heterozygous mutation in the TUBB3 gene on chromosome 16q24.", "url": "https://disease-ontology.org/term/DOID:0081017", "evidence": [ { "id": "0081017", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0081017" } ], "weight": 0.0 }, { "disease_id": "DOID:0090041", "name": "torsion 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"database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0090102" } ], "weight": 0.0 }, { "disease_id": "DOID:0090132", "name": "complex cortical dysplasia with other brain malformations 7", "description": "A complex cortical dysplasia with other brain malformations that is characterized by abnormalities in coritcal brain development that has_material_basis_in autosomal dominant inheritance of heterozygous mutation in the tubulin beta 2B class IIb (TUBB2B) gene on chromosome 6p25.", "url": "https://disease-ontology.org/term/DOID:0090132", "evidence": [ { "id": "0090132", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0090132" } ], "weight": 0.0 }, { "disease_id": "DOID:0090135", "name": "complex cortical dysplasia with other brain malformations 5", "description": "A complex cortical dysplasia with other brain malformations that has_material_basis_in autosomal dominant inheritance of heterozygous mutation in the tubulin beta 2A class IIa (TUBB2A) gene on chromosome 6p25.", "url": "https://disease-ontology.org/term/DOID:0090135", "evidence": [ { "id": "0090135", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0090135" } ], "weight": 0.0 }, { "disease_id": "DOID:0090136", "name": "complex cortical dysplasia with other brain malformations 6", "description": "A complex cortical dysplasia with other brain malformations that has_material_basis_in autosomal dominant inheritance of heterozygous mutation in the tubulin beta class I (TUBB) gene on chromosome 6p21.", "url": "https://disease-ontology.org/term/DOID:0090136", "evidence": [ { "id": "0090136", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0090136" } ], "weight": 0.0 }, { "disease_id": "DOID:0090137", "name": "complex cortical dysplasia with other brain malformations 1", "description": "A complex cortical dysplasia with other brain malformations that has_material_basis_in autosomal dominant inheritance of heterozygous mutation in the tubulin beta 3 class III (TUBB3) gene on chromosome 16q24.3.", "url": "https://disease-ontology.org/term/DOID:0090137", "evidence": [ { "id": "0090137", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0090137" } ], "weight": 0.0 }, { "disease_id": "DOID:0112227", "name": "tubulinopathy", "description": "A congenital nervous system abnormality characterized by complex cortical malformations including in most cases dysmorphic basal ganglia that has_material_basis_in mutation in one or more of the tubulin genes.", "url": "https://disease-ontology.org/term/DOID:0112227", "evidence": [ { "id": "0112227", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0112227" } ], "weight": 0.0 }, { "disease_id": "DOID:0112240", "name": "Leber congenital amaurosis with early-onset deafness", "description": "A sensory system disease characterized by early-onset and severe photoreceptor and cochlear cell loss that has_material_basis_in heterozygous mutation 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"https://disease-ontology.org/term/DOID:10283", "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ], "weight": 0.0 }, { "disease_id": "DOID:10907", "name": "microcephaly", "description": "A congenital nervous system abnormality that is characterized by a significantly smaller than normal head in infants.", "url": "https://disease-ontology.org/term/DOID:10907", "evidence": [ { "id": "10907", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10907" } ], "weight": 0.0 }, { "disease_id": "DOID:11870", "name": "Pick's disease", "description": "A frontotemporal dementia that is characterized by a spectrum of neuropsychiatric symptoms ranging from those that affect the patient's personality to those that cause a decline in cognitive function.", "url": "https://disease-ontology.org/term/DOID:11870", "evidence": [ { "id": "11870", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11870" } ], 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reproductive organ cancer that is located_in the ovary.", "url": "https://disease-ontology.org/term/DOID:2394", "evidence": [ { "id": "2394", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2394" } ], "weight": 0.0 }, { "disease_id": "DOID:3069", "name": "malignant astrocytoma", "description": "A malignant glioma that is has_material_basis_in astrocyte cells, a type of star-shaped glial cell, located in the brain and spinal cord.", "url": "https://disease-ontology.org/term/DOID:3069", "evidence": [ { "id": "3069", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3069" } ], "weight": 0.0 }, { "disease_id": "DOID:3213", "name": "demyelinating disease", "description": "A central nervous system disease that is characterized by damage to the myelin sheath present around nerve axons.", "url": "https://disease-ontology.org/term/DOID:3213", "evidence": [ { "id": "3213", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3213" } 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Angle-closure glaucoma has_symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Angle closure glaucoma can be caused by anatomically narrow angle, injury to the trabecular meshwork, and injuries to the anterior chamber, such as neovascularization and uveitis.", "url": "https://disease-ontology.org/term/DOID:13550", "evidence": [ { "id": "13550", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13550" } ], "weight": 0.0 }, { "disease_id": "DOID:13580", "name": "cholestasis", "description": "A bile duct disease that is characterized by where bile cannot flow from the liver to the duodenum.", "url": "https://disease-ontology.org/term/DOID:13580", "evidence": [ { "id": "13580", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13580" } ], "weight": 0.0 }, { "disease_id": "DOID:1459", "name": "hypothyroidism", "description": "A thyroid gland disease which involves an underproduction of thyroid hormone.", "url": "https://disease-ontology.org/term/DOID:1459", "evidence": [ { "id": "1459", "database": "AGR", "url": 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bowel and the eye.", "url": "https://disease-ontology.org/term/DOID:1909", "evidence": [ { "id": "1909", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1909" } ], "weight": 0.0 }, { "disease_id": "DOID:2316", "name": "brain ischemia", "description": "An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand.", "url": "https://disease-ontology.org/term/DOID:2316", "evidence": [ { "id": "2316", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2316" } ], "weight": 0.0 }, { "disease_id": "DOID:2527", "name": "nephrosis", "description": "A proteinuria that is characterized by the leaking of blood protein into the urine, swelling or edema, and degenerative lesions without inflammation.", "url": "https://disease-ontology.org/term/DOID:2527", "evidence": [ { "id": "2527", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2527" } ], "weight": 0.0 }, { "disease_id": "DOID:2582", "name": "acatalasia", "description": "A peroxisomal disease characterized by loss of catalase activity in erythrocytes that has_material_basis_in homozygous mutation in the CAT gene on chromosome 11p13.", "url": "https://disease-ontology.org/term/DOID:2582", "evidence": [ { "id": "2582", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2582" } ], "weight": 0.0 }, { "disease_id": "DOID:2738", "name": "pseudoxanthoma elasticum", "description": "A connective tissue disease that is characterized by the accumulation of deposits of calcium and other minerals in elastic fibers, which are a component of connective tissue, this can result in changes in the skin, eyes, cardiovascular system and gastrointestinal system.", "url": "https://disease-ontology.org/term/DOID:2738", "evidence": [ { "id": "2738", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2738" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:2876", "name": "laryngeal squamous cell carcinoma", "description": "A laryngeal carcinoma that has_material_basis_in squamous cells.", "url": "https://disease-ontology.org/term/DOID:2876", "evidence": [ { "id": "2876", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2876" } ], "weight": 0.0 }, { "disease_id": "DOID:2987", "name": "familial Mediterranean fever", "description": "An autoinflammatory disease characterized by recurrent episodes of fever and acute inflammation of the membranes lining the abdomen, joints and lungs; that has_material_basis_in mutations in the MEFV gene, which encodes the protein pyrin.", "url": "https://disease-ontology.org/term/DOID:2987", "evidence": [ { "id": "2987", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2987" } ], "weight": 0.0 }, { "disease_id": "DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:3458", "name": "breast adenocarcinoma", "description": "A breast carcinoma that originates in the milk ducts and/or lobules (glandular tissue) of the breast.", "url": "https://disease-ontology.org/term/DOID:3458", "evidence": [ { "id": "3458", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3458" } ], "weight": 0.0 }, { "disease_id": "DOID:3602", "name": "toxic encephalopathy", "description": "A nervous system disease that results from exposure to neurotoxicants and is characterized by an altered mental status, memory loss, and visual problems.", "url": "https://disease-ontology.org/term/DOID:3602", "evidence": [ { "id": "3602", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3602" } ], "weight": 0.0 }, { "disease_id": "DOID:3717", "name": "gastric adenocarcinoma", "description": "A stomach carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:3717", "evidence": [ { "id": "3717", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3717" } ], "weight": 0.0 }, { "disease_id": "DOID:3770", "name": "pulmonary fibrosis", "description": "An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation. It can be caused by inhaling hazardous chemicals, certain diseases, medication and genetics or unknown causes.", "url": "https://disease-ontology.org/term/DOID:3770", "evidence": [ { "id": "3770", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3770" } ], "weight": 0.0 }, { "disease_id": "DOID:3969", "name": "papillary thyroid carcinoma", "description": "A differentiated thyroid gland carcinoma that is characterized by the small mushroom shape of the tumor which has a stem attached to the epithelial layer and arises from the follicular cells of the thyroid gland.", "url": "https://disease-ontology.org/term/DOID:3969", "evidence": [ { "id": "3969", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3969" } ], "weight": 0.0 }, { "disease_id": "DOID:5199", "name": "ureteral obstruction", "description": "An urinary tract obstruction that is characterized by a blockage in one or both of the tubes (ureters) that carry urine from the kidneys to the bladder.", "url": "https://disease-ontology.org/term/DOID:5199", "evidence": [ { "id": "5199", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5199" } ], "weight": 0.0 }, { "disease_id": "DOID:5679", "name": "retinal disease", "description": "An eye disease that is located_in the retina.", "url": "https://disease-ontology.org/term/DOID:5679", "evidence": [ { "id": "5679", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5679" } ], "weight": 0.0 }, { "disease_id": "DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.", "url": "https://disease-ontology.org/term/DOID:5844", "evidence": [ { "id": "5844", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ], "weight": 0.0 }, { "disease_id": "DOID:585", "name": "nephrolithiasis", "description": "A kidney disease characterized by the formation of stoney concentrations in the kidneys.", "url": "https://disease-ontology.org/term/DOID:585", "evidence": [ { "id": "585", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:585" } ], "weight": 0.0 }, { "disease_id": "DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.", "url": "https://disease-ontology.org/term/DOID:6000", "evidence": [ { "id": "6000", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ], "weight": 0.0 }, { "disease_id": "DOID:631", "name": "fibromyalgia", "description": "A syndrome that is is characterized by chronic widespread musculoskeletal pain, fatigue, sleep disturbances, cognitive dysfunction and depression.", "url": "https://disease-ontology.org/term/DOID:631", "evidence": [ { "id": "631", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:631" } ], "weight": 0.0 }, { "disease_id": "DOID:6543", "name": "acne", "description": "A sebaceous gland disease characterized by areas of blackheads, whiteheads, pimples, greasy skin, and possibly scarring.", "url": "https://disease-ontology.org/term/DOID:6543", "evidence": [ { "id": "6543", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6543" } ], "weight": 0.0 }, { "disease_id": "DOID:670", "name": "amphetamine abuse", "description": "A substance abuse that involves the recurring use of amphetamines despite negative consequences.", "url": "https://disease-ontology.org/term/DOID:670", "evidence": [ { "id": "670", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:670" } ], "weight": 0.0 }, { "disease_id": "DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.", "url": "https://disease-ontology.org/term/DOID:684", "evidence": [ { "id": "684", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:684" } ], "weight": 0.0 }, { "disease_id": "DOID:783", "name": "end stage renal disease", "description": "A chronic kidney disease is characterized by non-functioning kidneys, as the final stage in chronic kidney disease.", "url": "https://disease-ontology.org/term/DOID:783", "evidence": [ { "id": "783", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:783" } ], "weight": 0.0 }, { "disease_id": "DOID:7998", "name": "hyperthyroidism", "description": "A thyroid gland disease that involves an over production of thyroid hormone.", "url": "https://disease-ontology.org/term/DOID:7998", "evidence": [ { "id": "7998", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:7998" } ], "weight": 0.0 }, { "disease_id": "DOID:8295", "name": "scabies", "description": "A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.", "url": "https://disease-ontology.org/term/DOID:8295", "evidence": [ { "id": "8295", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8295" } ], "weight": 0.0 }, { "disease_id": "DOID:83", "name": "cataract", "description": "A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision.", "url": "https://disease-ontology.org/term/DOID:83", "evidence": [ { "id": "83", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:83" } ], "weight": 0.0 }, { "disease_id": "DOID:850", "name": "lung disease", "description": "A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide.", "url": "https://disease-ontology.org/term/DOID:850", "evidence": [ { "id": "850", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:850" } ], "weight": 0.0 }, { "disease_id": "DOID:874", "name": "bacterial pneumonia", "description": "A pneumonia involving inflammation of the lungs caused by bacteria.", "url": "https://disease-ontology.org/term/DOID:874", "evidence": [ { "id": "874", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:874" } ], "weight": 0.0 }, { "disease_id": "DOID:8741", "name": "seborrheic dermatitis", "description": "A dermatitis that is an inflammatory skin condition resulting in flaky, white to yellowish scales on oily areas such as the scalp or inside the ear, which is caused due to a combination of an over production of skin oil and irritation from a yeast Malassezia furfur. The symptoms include itching, skin lesions and scales, redness, plaques and hair loss.", "url": "https://disease-ontology.org/term/DOID:8741", "evidence": [ { "id": "8741", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8741" } ], "weight": 0.0 }, { "disease_id": "DOID:8893", "name": "psoriasis", "description": "A skin disease that is characterized by patches of thick red skin and silvery scales.", "url": "https://disease-ontology.org/term/DOID:8893", "evidence": [ { "id": "8893", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8893" } ], "weight": 0.0 }, { "disease_id": "DOID:8947", "name": "diabetic retinopathy", "description": "", "url": "https://disease-ontology.org/term/DOID:8947", "evidence": [ { "id": "8947", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8947" } ], "weight": 0.0 }, { "disease_id": "DOID:9111", "name": "cutaneous leishmaniasis", "description": "A leishmaniasis that involves skin infection caused by Leishmania species, resulting in one or more cutaneous lesions.", "url": "https://disease-ontology.org/term/DOID:9111", "evidence": [ { "id": "9111", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9111" } ], "weight": 0.0 }, { "disease_id": "DOID:9182", "name": "pemphigus", "description": "An autoimmune disease of skin and connective tissue that is characterized by blistering of the outer layer of the skin and mucous membranes (mouth, nose, throat, eyes, and genitals), causing lesions and blisters that are easily ruptured.", "url": "https://disease-ontology.org/term/DOID:9182", "evidence": [ { "id": "9182", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9182" } ], "weight": 0.0 }, { "disease_id": "DOID:9201", "name": "lichen planus", "description": "A lichen disease that is located_in skin, located_in tongue or located_in oral mucosa, which presents itself in the form of papules, lesions or rashes.", "url": "https://disease-ontology.org/term/DOID:9201", "evidence": [ { "id": "9201", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9201" } ], "weight": 0.0 }, { "disease_id": "DOID:9281", "name": "phenylketonuria", "description": "An amino acid metabolic disorder that is characterized by a mutation in the gene for the hepatic enzyme phenylalanine hydroxylase (PAH), rendering it nonfunctional.", "url": "https://disease-ontology.org/term/DOID:9281", "evidence": [ { "id": "9281", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9281" } ], "weight": 0.0 }, { "disease_id": "DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.", "url": "https://disease-ontology.org/term/DOID:9352", "evidence": [ { "id": "9352", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ], "weight": 0.0 }, { "disease_id": "DOID:9452", "name": "steatotic liver disease", "description": "A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in at least 5% of hepatocytes.", "url": "https://disease-ontology.org/term/DOID:9452", "evidence": [ { "id": "9452", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9452" } ], "weight": 0.0 }, { "disease_id": "DOID:9637", "name": "stomatitis", "description": "A mouth disease that is characterized by inflammation of the mouth and lips.", "url": "https://disease-ontology.org/term/DOID:9637", "evidence": [ { "id": "9637", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9637" } ], "weight": 0.0 }, { "disease_id": "DOID:9669", "name": "senile cataract", "description": "A cataract that is characterized by thickening and loss of transparency of the lens with age progression, caused by a multifactorial etiology related to aging.", "url": "https://disease-ontology.org/term/DOID:9669", "evidence": [ { "id": "9669", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9669" } ], "weight": 0.0 }, { "disease_id": "DOID:9719", "name": "neovascular inflammatory vitreoretinopathy", "description": "A retinal and vitreous disease characterized by ocular inflammation, vascular dropout, large spots of hyperpigmentation, neovascularization of the peripheral and posterior retina, vitreous hemorrhage, and retinal detachment that has_material_basis_in heterozygous mutation in the CAPN5 gene on chromosome 11q13.5.", "url": "https://disease-ontology.org/term/DOID:9719", "evidence": [ { "id": "9719", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9719" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P06115", "url": "https://www.uniprot.org/uniprotkb/P06115" } ], "pmid": "" }, { "name": 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and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.", "url": "https://disease-ontology.org/term/DOID:10652", "evidence": [ { "id": "10652", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ], "weight": 0.0 }, { "disease_id": "DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder.", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ], "weight": 0.0 }, { "disease_id": 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melanocytes which are found in skin, the bowel and the eye.", "url": "https://disease-ontology.org/term/DOID:1909", "evidence": [ { "id": "1909", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1909" } ], "weight": 0.0 }, { "disease_id": "DOID:2152", "name": "ovary epithelial cancer", "description": "An ovarian cancer that is derives_from ovarian surface epithelium.", "url": "https://disease-ontology.org/term/DOID:2152", "evidence": [ { "id": "2152", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2152" } ], "weight": 0.0 }, { "disease_id": "DOID:2960", "name": "photosensitive trichothiodystrophy", "description": "A trichothiodystrophy characterized by skin that is extremely sensitive to ultraviolet (UV) rays from sunlight.", "url": "https://disease-ontology.org/term/DOID:2960", "evidence": [ { "id": "2960", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2960" } ], "weight": 0.0 }, { "disease_id": "DOID:2962", "name": "Cockayne syndrome", "description": "A syndrome that is characterized by an abnormally small head size (microcephaly), a failure to gain weight and grow at the expected rate (failure to thrive) leading to very short stature, and delayed development.", "url": "https://disease-ontology.org/term/DOID:2962", "evidence": [ { "id": "2962", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2962" } ], "weight": 0.0 }, { "disease_id": "DOID:3070", "name": "high grade glioma", "description": "A cell type cancer that has_material_basis_in glial cells and is located in brain or located in spine.", "url": "https://disease-ontology.org/term/DOID:3070", "evidence": [ { "id": "3070", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3070" } ], "weight": 0.0 }, { "disease_id": "DOID:3393", "name": "coronary artery disease", "description": "An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart 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"name": "macular degeneration", "description": "A retinal degeneration characterized by gradual deterioration of light-sensing cells in the tissues at the back of the eye and has_symptom vision loss.", "url": "https://disease-ontology.org/term/DOID:4448", "evidence": [ { "id": "4448", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4448" } ], "weight": 0.0 }, { "disease_id": "DOID:635", "name": "acquired immunodeficiency syndrome", "description": "A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per microliter of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 (Lentivirus humimdef1) or Human immunodeficiency virus 2 (Lentivirus humimdef2), which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or 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"glygen_name": "Yeast", "reference_species": "Saccharomyces cerevisiae S288C [559292]" } ], "length": 405, "chemical_mass": 44499.0, "gene_names": "PEP4;P2585;PEP4;PHO9;PRA1;yscA", "protein_name": "Saccharopepsin", "disease": [ { "disease_id": "DOID:0050811", "name": "congenital adrenal hyperplasia", "description": "A steroid inherited metabolic disorder that is characterized by adrenal insufficiency and variable degrees of hyper or hypo androgyny manifestations resulting from steroidogenic enzyme deficiency.", "url": "https://disease-ontology.org/term/DOID:0050811", "evidence": [ { "id": "0050811", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050811" } ], "weight": 0.0 }, { "disease_id": "DOID:0060224", "name": "atrial fibrillation", "description": "A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has symptoms 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This disease is distinguished from MASLD by increased alcohol consumption and from ALD by the evidence of one or more of the specified cardiometabolic risk factors. The five cardiometabolic risk factors are: (1) higher than normal body mass index or waist circumference; (2) higher than normal serum glucose or glycated hemoglobin level, or type 2 diabetes; (3) higher than normal blood pressure or hypertensive treatment; (4) higher than normal plasma triglycerides or lipid lowering treatment; and (5) lower than normal plasma high-density lipoprotein cholesterol.", "url": "https://disease-ontology.org/term/DOID:0070508", "evidence": [ { "id": "0070508", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070508" } ], "weight": 0.0 }, { "disease_id": "DOID:0080600", "name": "COVID-19", "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum.", "url": "https://disease-ontology.org/term/DOID:0080600", "evidence": [ { "id": "0080600", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080600" } ], "weight": 0.0 }, { "disease_id": "DOID:0080827", "name": "human cytomegalovirus infection", "description": "A viral infectious disease that has_material_basis_in Human betaherpesvirus 5 (Cytomegalovirus humanbeta5).", "url": "https://disease-ontology.org/term/DOID:0080827", "evidence": [ { "id": "0080827", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080827" } ], "weight": 0.0 }, { "disease_id": "DOID:0110725", "name": "neuronal ceroid lipofuscinosis 10", "description": "A neuronal ceroid lipofuscinosis that has_material_basis_in homozygous or compound heterozygous mutation in the CTSD gene on chromosome 11p15.", "url": "https://disease-ontology.org/term/DOID:0110725", "evidence": [ { "id": "0110725", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110725" } ], "weight": 0.0 }, { "disease_id": "DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.", "url": "https://disease-ontology.org/term/DOID:10652", "evidence": [ { "id": "10652", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ], "weight": 0.0 }, { "disease_id": "DOID:10762", "name": "portal hypertension", "description": "", "url": "https://disease-ontology.org/term/DOID:10762", "evidence": [ { "id": "10762", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10762" } ], "weight": 0.0 }, { "disease_id": "DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries.", "url": "https://disease-ontology.org/term/DOID:10763", "evidence": [ { "id": "10763", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ], "weight": 0.0 }, { "disease_id": "DOID:10825", "name": "essential hypertension", "description": "A hypertension with no known cause. 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The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.", "url": "https://disease-ontology.org/term/DOID:10881", "evidence": [ { "id": "10881", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10881" } ], "weight": 0.0 }, { "disease_id": "DOID:12236", "name": "primary biliary cholangitis", "description": "A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts.", "url": "https://disease-ontology.org/term/DOID:12236", "evidence": [ { "id": "12236", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12236" } ], "weight": 0.0 }, { "disease_id": "DOID:14115", "name": "toxic shock syndrome", "description": "A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus, which produce toxins that are absorbed systemically and produce the systemic manifestations. 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"description": "An allergic contact dermatitis that is a chronically relapsing inflammatory allergic response located_in the skin that causes itching and flaking.", "url": "https://disease-ontology.org/term/DOID:3310", "evidence": [ { "id": "3310", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3310" } ], "weight": 0.0 }, { "disease_id": "DOID:446", "name": "primary hyperaldosteronism", "description": "An adrenal gland hyperfunction disease that results in the overproduction of aldosterone by the adrenal glands.", "url": "https://disease-ontology.org/term/DOID:446", "evidence": [ { "id": "446", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:446" } ], "weight": 0.0 }, { "disease_id": "DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.", "url": "https://disease-ontology.org/term/DOID:5844", "evidence": [ { "id": "5844", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ], "weight": 0.0 }, { "disease_id": "DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.", "url": "https://disease-ontology.org/term/DOID:6000", "evidence": [ { "id": "6000", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ], "weight": 0.0 }, { "disease_id": "DOID:8544", "name": "chronic fatigue syndrome", "description": "A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to exertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions.", "url": "https://disease-ontology.org/term/DOID:8544", "evidence": [ { "id": "8544", "database": "AGR", "url": 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multiple nevi flammei", "description": "A capillary disease characterized by dark red to purple, nonelevated, sharply circumscribed patches which blanch on pressure with a glass, do not spontaneously regress, and have normal rates endothelial cell turnover.", "url": "https://disease-ontology.org/term/DOID:0111529", "evidence": [ { "id": "0111529", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111529" } ], "weight": 0.0 }, { "disease_id": "DOID:0111563", "name": "Sturge-Weber syndrome", "description": "A vascular disease characterized by intracranial vascular anomaly, leptomeningeal angiomatosis, facial cutaneous vascular malformations, and glaucoma that has_material_basis_in somatic mutation in the GNAQ gene on chromosome 9q21.2.", "url": "https://disease-ontology.org/term/DOID:0111563", "evidence": [ { "id": "0111563", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111563" } ], "weight": 0.0 }, { "disease_id": "DOID:0112202", "name": 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"https://www.alliancegenome.org/disease/DOID:0060036" } ], "weight": 0.0 }, { "disease_id": "DOID:0060610", "name": "megacystis-microcolon-intestinal hypoperistalsis syndrome", "description": "A syndrome that is characterized by marked dilatation of the bladder and microcolon and decreased intestinal peristalsis.", "url": "https://disease-ontology.org/term/DOID:0060610", "evidence": [ { "id": "0060610", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060610" } ], "weight": 0.0 }, { "disease_id": "DOID:0060651", "name": "MYH-9 related disease", "description": "A blood platelet disease that has_material_basis_in mutations in the MYH9 gene. 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"url": "https://disease-ontology.org/term/DOID:0080326", "evidence": [ { "id": "0080326", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080326" } ], "weight": 0.0 }, { "disease_id": "DOID:0080719", "name": "congenital myopathy 6", "description": "A congenital myopathy that is characterized by childhood onset of congenital joint contractures, external ophthalmoplegia, and proximal muscle weakness, and that has_material_basis_in heterozygous, compound heterozygous, or homozygous mutation in the gene encoding myosin heavy chain IIa ( (MYHC2A or MYH2) on chromosome 17p13.", "url": "https://disease-ontology.org/term/DOID:0080719", "evidence": [ { "id": "0080719", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080719" } ], "weight": 0.0 }, { "disease_id": "DOID:0080954", "name": "arthrogryposis multiplex congenita", "description": "A nervous system disease that is characterized by development of multiple joint contractures affecting two or more areas of the body prior to birth.", "url": "https://disease-ontology.org/term/DOID:0080954", "evidence": [ { "id": "0080954", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080954" } ], "weight": 0.0 }, { "disease_id": "DOID:0081321", "name": "contractures, pterygia, and spondylocarpotarsal fusion syndrome 1A", "description": "A contractures, pterygia, and spondylocarpotarsal fusion syndrome that is characterized by contractures of proximal and distal joints, pterygia involving the neck, axillae, elbows, and/or knees, as well as variable vertebral, carpal, and tarsal fusions and short stature and that has material_basis_in heterozygous mutation in the MYH3 gene on chromosome 17p13.", "url": "https://disease-ontology.org/term/DOID:0081321", "evidence": [ { "id": "0081321", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0081321" } ], "weight": 0.0 }, { "disease_id": "DOID:0081322", "name": "contractures, pterygia, and spondylocarpotarsal fusion syndrome 1B", "description": "A contractures, pterygia, and spondylocarpotarsal fusion syndrome that is characterized by contractures of proximal and distal joints, pterygia involving the neck, elbows, fingers, and/or knees, and variable vertebral, carpal, and tarsal fusions and that has_material_basis_in compound heterozygous mutation in the MYH3 gene on chromosome 17p13.", "url": "https://disease-ontology.org/term/DOID:0081322", "evidence": [ { "id": "0081322", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0081322" } ], "weight": 0.0 }, { "disease_id": "DOID:0090116", "name": "spondylocarpotarsal synostosis syndrome", "description": "A bone development disease that is characterized by postnatal progressive vertebral fusions frequently manifesting as block vertebrae, contributing to an undersized trunk and a disproportionate short stature, scoliosis, lordosis, carpal and tarsal synostosis, with club feet and a mild facial dysmorphism, and that has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the filamin B (FLNB) gene on chromosome 3p14.3.", "url": "https://disease-ontology.org/term/DOID:0090116", "evidence": [ { "id": "0090116", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0090116" } ], "weight": 0.0 }, { "disease_id": "DOID:0110032", "name": "Alport syndrome 3A", "description": "An Alport syndrome that has_material_basis_in heterozygous mutation in the COL4A3 gene.", "url": "https://disease-ontology.org/term/DOID:0110032", "evidence": [ { "id": "0110032", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110032" } ], "weight": 0.0 }, { "disease_id": "DOID:0110108", "name": "atrial heart septal defect 3", "description": "An atrial heart septal defect type 3 that has_material_basis_in heterozygous mutation in the myosin heavy chain-6 gene (MYH6) on chromosome 14q12.", "url": "https://disease-ontology.org/term/DOID:0110108", "evidence": [ { "id": "0110108", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110108" } ], "weight": 0.0 }, { "disease_id": "DOID:0110307", "name": "hypertrophic cardiomyopathy 1", "description": "A familial hypertrophic cardiomyopathy that has_material_basis_in heterozygous mutation in the MYH7 gene on chromosome 14q12.", "url": "https://disease-ontology.org/term/DOID:0110307", "evidence": [ { "id": "0110307", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110307" } ], "weight": 0.0 }, { "disease_id": "DOID:0110320", "name": "hypertrophic cardiomyopathy 14", "description": "A familial hypertrophic cardiomyopathy that has_material_basis_in mutation in the MYH6 gene.", "url": "https://disease-ontology.org/term/DOID:0110320", "evidence": [ { "id": "0110320", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110320" } ], "weight": 0.0 }, { "disease_id": "DOID:0110453", "name": "dilated cardiomyopathy 1EE", "description": "A dilated cardiomyopathy that has_material_basis_in mutation in the MYH6 gene on chromosome 14q11.2.", "url": "https://disease-ontology.org/term/DOID:0110453", "evidence": [ { "id": "0110453", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110453" } ], "weight": 0.0 }, { "disease_id": "DOID:0110454", "name": "dilated cardiomyopathy 1S", "description": "A dilated cardiomyopathy that has_material_basis_in mutation in the MYH7 gene on chromosome 14q12.", "url": "https://disease-ontology.org/term/DOID:0110454", "evidence": [ { "id": "0110454", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110454" } ], "weight": 0.0 }, { "disease_id": "DOID:0110548", "name": "autosomal dominant nonsyndromic deafness 17", "description": "An autosomal dominant nonsyndromic deafness that is characterized by postlingual onset with high frequency progressive hearing loss and has_material_basis_in mutation in the MYH9 gene on chromosome 22q12.", "url": "https://disease-ontology.org/term/DOID:0110548", "evidence": [ { "id": "0110548", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110548" } ], "weight": 0.0 }, { "disease_id": "DOID:0110573", "name": "autosomal dominant nonsyndromic deafness 4A", "description": "An autosomal dominant nonsyndromic deafness that is characterized by postlingual onset with flat or gently sloping hearing audioprofiles and has_material_basis_in mutation in the MYH14 gene on chromosome 19q13.33.", "url": "https://disease-ontology.org/term/DOID:0110573", "evidence": [ { "id": "0110573", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110573" } ], "weight": 0.0 }, { "disease_id": "DOID:0111268", "name": "autosomal recessive hyaline body myopathy", "description": "A hyaline body myopathy that has_material_basis_in compound heterozygous or homozygous mutation in MYH7 on 14q11.2.", "url": "https://disease-ontology.org/term/DOID:0111268", "evidence": [ { "id": "0111268", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111268" } ], "weight": 0.0 }, { "disease_id": "DOID:0111269", "name": "autosomal dominant hyaline body myopathy", "description": "A hyaline body myopathy that has_material_basis_in heterozygous mutation in MYH7 on 14q11.2.", "url": "https://disease-ontology.org/term/DOID:0111269", "evidence": [ { "id": "0111269", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111269" } ], "weight": 0.0 }, { "disease_id": "DOID:0111596", "name": "distal arthrogryposis type 1", "description": "A distal arthrogryposis characterized by autosomal domiant inheritance of contractures of the distal regions of the hands and feet with no facial involvement or other anomalies.", "url": "https://disease-ontology.org/term/DOID:0111596", "evidence": [ { "id": "0111596", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111596" } ], "weight": 0.0 }, { "disease_id": "DOID:0111599", "name": "distal arthrogryposis type 2B", "description": "A distal arthrogryposis characterized by contractures of the distal joints of the limbs, triangular face, downslanting palpebral fissures, small mouth, and high arched palate.", "url": "https://disease-ontology.org/term/DOID:0111599", "evidence": [ { "id": "0111599", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111599" } ], "weight": 0.0 }, { "disease_id": "DOID:0111602", "name": "distal arthrogryposis type 2B3", "description": "A distal arthrogryposis type 2B that has_material_basis_in heterozygous mutation in the MYH3 gene on chromosome 17p13.1.", "url": "https://disease-ontology.org/term/DOID:0111602", "evidence": [ { "id": "0111602", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111602" } ], "weight": 0.0 }, { "disease_id": "DOID:0111603", "name": "distal arthrogryposis type 7", "description": "A distal arthrogryposis characterized by inability to open the mouth fully and pseudocamptodactyly that has_material_basis_in heterozygous mutation in the MYH8 gene on chromosome 17p13.1.", "url": "https://disease-ontology.org/term/DOID:0111603", "evidence": [ { "id": "0111603", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111603" } ], "weight": 0.0 }, { "disease_id": "DOID:0111605", "name": "distal arthrogryposis type 2A", "description": "A Freeman-Sheldon syndrome that has_material_basis_in heterozygous mutation in the MYH3 gene on chromosome 17p13.1.", "url": "https://disease-ontology.org/term/DOID:0111605", "evidence": [ { "id": "0111605", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111605" } ], "weight": 0.0 }, { "disease_id": "DOID:10003", "name": "sensorineural hearing loss", "description": "An inner ear disease that is characterized by hearing loss resulting from damage to the cochlea, auditory nerve and/or brainstem.", "url": "https://disease-ontology.org/term/DOID:10003", "evidence": [ { "id": "10003", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10003" } ], "weight": 0.0 }, { "disease_id": "DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries.", "url": "https://disease-ontology.org/term/DOID:10763", "evidence": [ { "id": "10763", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ], "weight": 0.0 }, { "disease_id": "DOID:114", "name": "heart disease", "description": "A cardiovascular system disease that involves the heart.", "url": "https://disease-ontology.org/term/DOID:114", "evidence": [ { "id": "114", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:114" } ], "weight": 0.0 }, { "disease_id": "DOID:11446", "name": "sciatic neuropathy", "description": "", "url": "https://disease-ontology.org/term/DOID:11446", "evidence": [ { "id": "11446", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11446" } ], "weight": 0.0 }, { "disease_id": "DOID:11720", "name": "distal myopathy", "description": "A muscular dystrophy that is characterized by predominant weakness and atrophy beginning in the feet and/or hands.", "url": "https://disease-ontology.org/term/DOID:11720", "evidence": [ { "id": "11720", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11720" } ], "weight": 0.0 }, { "disease_id": "DOID:11984", "name": "hypertrophic cardiomyopathy", "description": "An intrinsic cardiomyopathy that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause.", "url": "https://disease-ontology.org/term/DOID:11984", "evidence": [ { "id": "11984", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11984" } ], "weight": 0.0 }, { "disease_id": "DOID:12930", "name": "dilated cardiomyopathy", "description": "An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently.", "url": "https://disease-ontology.org/term/DOID:12930", "evidence": [ { "id": "12930", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12930" } ], "weight": 0.0 }, { "disease_id": "DOID:13832", "name": "patent ductus arteriosus", "description": "", "url": "https://disease-ontology.org/term/DOID:13832", "evidence": [ { "id": "13832", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13832" } ], "weight": 0.0 }, { "disease_id": "DOID:13884", "name": "sick sinus syndrome", "description": "", "url": "https://disease-ontology.org/term/DOID:13884", "evidence": [ { "id": "13884", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13884" } ], "weight": 0.0 }, { "disease_id": "DOID:14004", "name": "thoracic aortic aneurysm", "description": "An aortic aneurysm that is located_in the thoracic aorta.", "url": "https://disease-ontology.org/term/DOID:14004", "evidence": [ { "id": "14004", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14004" } ], "weight": 0.0 }, { "disease_id": "DOID:14566", "name": "disease of cellular proliferation", "description": "A disease that is characterized by abnormally rapid cell division.", "url": "https://disease-ontology.org/term/DOID:14566", "evidence": [ { "id": "14566", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14566" } ], "weight": 0.0 }, { "disease_id": "DOID:1459", "name": "hypothyroidism", "description": "A thyroid gland disease which involves an underproduction of thyroid hormone.", "url": "https://disease-ontology.org/term/DOID:1459", "evidence": [ { "id": "1459", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1459" } ], "weight": 0.0 }, { "disease_id": "DOID:1588", "name": "thrombocytopenia", "description": "A blood platelet disease that is characterized by low a platelet count in the blood.", "url": "https://disease-ontology.org/term/DOID:1588", "evidence": [ { "id": "1588", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1588" } ], "weight": 0.0 }, { "disease_id": "DOID:1682", "name": "congenital heart disease", "description": "A physical disorder that is characterized by problems with the heart's structure that are present at birth.", "url": "https://disease-ontology.org/term/DOID:1682", "evidence": [ { "id": "1682", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1682" } ], "weight": 0.0 }, { "disease_id": "DOID:1882", "name": "atrial heart septal defect", "description": "A heart septal defect located_in in the septum that separates the two atria of the heart.", "url": "https://disease-ontology.org/term/DOID:1882", "evidence": [ { "id": "1882", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1882" } ], "weight": 0.0 }, { "disease_id": "DOID:2106", "name": "myotonia congenita", "description": "A muscle tissue disease that is characterized by slow muscle relaxation associated with hyperexcitation of the muscle fibres.", "url": "https://disease-ontology.org/term/DOID:2106", "evidence": [ { "id": "2106", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2106" } ], "weight": 0.0 }, { "disease_id": "DOID:3429", "name": "inclusion body myositis", "description": "A myositis that is characterized by late onset of skeletal muscle inflammation, weakness, and atrophy with cytoplasmic granules and vacuoles in the muscle.", "url": "https://disease-ontology.org/term/DOID:3429", "evidence": [ { "id": "3429", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3429" } ], "weight": 0.0 }, { "disease_id": "DOID:384", "name": "Wolff-Parkinson-White syndrome", "description": "", "url": "https://disease-ontology.org/term/DOID:384", "evidence": [ { "id": "384", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:384" } ], "weight": 0.0 }, { "disease_id": "DOID:397", "name": "restrictive cardiomyopathy", "description": "An intrinsic cardiomyopathy characterized by impaired ventricular filling, with normal or decreased diastolic volume of either or both ventricles typically resulting from increased stiffness of the myocardium.", "url": "https://disease-ontology.org/term/DOID:397", "evidence": [ { "id": "397", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:397" } ], "weight": 0.0 }, { "disease_id": "DOID:423", "name": "myopathy", "description": "A muscular disease in which the muscle fibers do not function resulting in muscular weakness.", "url": "https://disease-ontology.org/term/DOID:423", "evidence": [ { "id": "423", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:423" } ], "weight": 0.0 }, { "disease_id": "DOID:557", "name": "kidney disease", "description": "A urinary system disease that is located_in the kidney.", "url": "https://disease-ontology.org/term/DOID:557", "evidence": [ { "id": "557", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:557" } ], "weight": 0.0 }, { "disease_id": "DOID:576", "name": "proteinuria", "description": "A kidney disease that is characterized by the presence of excess proteins in the urine.", "url": "https://disease-ontology.org/term/DOID:576", "evidence": [ { "id": "576", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:576" } ], "weight": 0.0 }, { "disease_id": "DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.", "url": "https://disease-ontology.org/term/DOID:5844", "evidence": [ { "id": "5844", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ], "weight": 0.0 }, { "disease_id": "DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.", "url": "https://disease-ontology.org/term/DOID:6000", "evidence": [ { "id": "6000", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ], "weight": 0.0 }, { "disease_id": "DOID:7693", "name": "abdominal aortic aneurysm", "description": "An aortic aneurysm that is located_in the abdominal aorta.", "url": "https://disease-ontology.org/term/DOID:7693", "evidence": [ { "id": "7693", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:7693" } ], "weight": 0.0 }, { "disease_id": "DOID:783", "name": "end stage renal disease", "description": "A chronic kidney disease is characterized by non-functioning kidneys, as the final stage in chronic kidney disease.", "url": "https://disease-ontology.org/term/DOID:783", "evidence": [ { "id": "783", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:783" } ], "weight": 0.0 }, { "disease_id": "DOID:9884", "name": "muscular dystrophy", "description": "A myopathy is characterized by progressive skeletal muscle weakness degeneration.", "url": "https://disease-ontology.org/term/DOID:9884", "evidence": [ { "id": "9884", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9884" } ], "weight": 0.0 }, { "disease_id": "DOID:9955", "name": "hypoplastic left heart syndrome", "description": "A congenital heart disease characterized by abnormal development of the left-sided structures of the heart.", "url": "https://disease-ontology.org/term/DOID:9955", "evidence": [ { "id": "9955", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9955" } ], "weight": 0.0 } ], "biological_process": [ { "name": "septum digestion after cytokinesis", "id": "GO:0000920", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000920", "evidence": [ { "database": "UniProtKB", 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"https://www.alliancegenome.org/disease/DOID:10140" } ], "weight": 0.0 }, { "disease_id": "DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.", "url": "https://disease-ontology.org/term/DOID:10652", "evidence": [ { "id": "10652", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ], "weight": 0.0 }, { "disease_id": "DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the 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the urinary bladder.", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ], "weight": 0.0 }, { "disease_id": "DOID:1229", "name": "paranoid schizophrenia", "description": "A schizophrenia characterized by delusions or auditory hallucinations of persecution or being plotted against without thought disorder, disorganized behavior, or affective flattening.", "url": "https://disease-ontology.org/term/DOID:1229", "evidence": [ { "id": "1229", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1229" } ], "weight": 0.0 }, { "disease_id": "DOID:12306", "name": "vitiligo", "description": "An autoimmune disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes.", "url": "https://disease-ontology.org/term/DOID:12306", "evidence": [ { "id": "12306", "database": "AGR", "url": 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Disease is located within the tunica intima of large and small arteries.", "url": "https://disease-ontology.org/term/DOID:1936", "evidence": [ { "id": "1936", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1936" } ], "weight": 0.0 }, { "disease_id": "DOID:224", "name": "transient cerebral ischemia", "description": "A brain ischemia that is characterized by ischemia of brief duration and without resultant tissue death.", "url": "https://disease-ontology.org/term/DOID:224", "evidence": [ { "id": "224", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:224" } ], "weight": 0.0 }, { "disease_id": "DOID:2316", "name": "brain ischemia", "description": "An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand.", "url": "https://disease-ontology.org/term/DOID:2316", "evidence": [ { "id": "2316", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2316" } ], "weight": 0.0 }, { "disease_id": "DOID:2377", "name": "multiple sclerosis", "description": "A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.", "url": "https://disease-ontology.org/term/DOID:2377", "evidence": [ { "id": "2377", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2377" } ], "weight": 0.0 }, { "disease_id": "DOID:2378", "name": "relapsing-remitting multiple sclerosis", "description": "A multiple sclerosis that is characterized by relapse (attacks of symptom flare-ups) followed by remission (periods of recovery). 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characterized by chronic elevated blood pressure in the arteries.", "url": "https://disease-ontology.org/term/DOID:10763", "evidence": [ { "id": "10763", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ], "weight": 0.0 }, { "disease_id": "DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder.", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ], "weight": 0.0 }, { "disease_id": "DOID:1229", "name": "paranoid schizophrenia", "description": "A schizophrenia characterized by delusions or auditory hallucinations of persecution or being plotted against without thought disorder, disorganized behavior, or affective flattening.", "url": "https://disease-ontology.org/term/DOID:1229", "evidence": [ { "id": "1229", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1229" } ], "weight": 0.0 }, { "disease_id": "DOID:12306", "name": "vitiligo", "description": "An autoimmune disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes.", "url": "https://disease-ontology.org/term/DOID:12306", "evidence": [ { "id": "12306", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12306" } ], "weight": 0.0 }, { "disease_id": "DOID:1287", "name": "cardiovascular system disease", "description": "A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.", "url": "https://disease-ontology.org/term/DOID:1287", "evidence": [ { "id": "1287", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1287" } ], "weight": 0.0 }, { "disease_id": "DOID:13141", "name": "uveitis", "description": "An uveal disease is characterized by inflammation of any of the layers of the uvea of the eye, which includes the iris, ciliary body, and choroid.", "url": "https://disease-ontology.org/term/DOID:13141", "evidence": [ { "id": "13141", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13141" } ], "weight": 0.0 }, { "disease_id": "DOID:13378", "name": "Kawasaki disease", "description": "A lymphadenitis characterized by swelling of cervical lymph nodes in infants and young children and inflammation of medium-sized blood vessels and that symptoms of fever, congestion of ocular conjunctivae, reddening of lips, reddening of oral cavity, protuberance of tongue papillae and edema of extremities.", "url": "https://disease-ontology.org/term/DOID:13378", "evidence": [ { "id": "13378", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13378" } ], "weight": 0.0 }, { "disease_id": "DOID:14115", "name": "toxic shock syndrome", "description": "A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus, which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities.", "url": "https://disease-ontology.org/term/DOID:14115", "evidence": [ { "id": "14115", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14115" } ], "weight": 0.0 }, { "disease_id": "DOID:14330", "name": "Parkinson's disease", "description": "A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.", "url": "https://disease-ontology.org/term/DOID:14330", "evidence": [ { "id": "14330", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14330" } ], "weight": 0.0 }, { "disease_id": "DOID:1470", "name": "major depressive disorder", "description": "A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality.", "url": "https://disease-ontology.org/term/DOID:1470", "evidence": [ { "id": "1470", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1470" } ], "weight": 0.0 }, { "disease_id": "DOID:1485", "name": "cystic fibrosis", "description": "A syndrome that is characterized by the buildup of thick, sticky mucus that can damage many organs.", "url": "https://disease-ontology.org/term/DOID:1485", "evidence": [ { "id": "1485", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1485" } ], "weight": 0.0 }, { "disease_id": "DOID:1824", "name": "status epilepticus", "description": "", "url": "https://disease-ontology.org/term/DOID:1824", "evidence": [ { "id": "1824", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1824" } ], "weight": 0.0 }, { "disease_id": "DOID:1936", "name": "atherosclerosis", "description": "An arteriosclerotic cardiovascular disease that is characterized by the build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen. Disease is located within the tunica intima of large and small arteries.", "url": "https://disease-ontology.org/term/DOID:1936", "evidence": [ { "id": "1936", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1936" } ], "weight": 0.0 }, { "disease_id": "DOID:224", "name": "transient cerebral ischemia", "description": "A brain ischemia that is characterized by ischemia of brief duration and without resultant tissue death.", "url": "https://disease-ontology.org/term/DOID:224", "evidence": [ { "id": "224", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:224" } ], "weight": 0.0 }, { "disease_id": "DOID:2316", "name": "brain ischemia", "description": "An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand.", "url": "https://disease-ontology.org/term/DOID:2316", "evidence": [ { "id": "2316", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2316" } ], "weight": 0.0 }, { "disease_id": "DOID:2377", "name": "multiple sclerosis", "description": "A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.", "url": "https://disease-ontology.org/term/DOID:2377", "evidence": [ { "id": "2377", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2377" } ], "weight": 0.0 }, { "disease_id": "DOID:2378", "name": "relapsing-remitting multiple sclerosis", "description": "A multiple sclerosis that is characterized by relapse (attacks of symptom flare-ups) followed by remission (periods of recovery). Symptoms may vary from mild to severe, and relapses and remissions may last for days or months. More than 80 percent of people who have MS begin with relapsing-remitting cycles.", "url": "https://disease-ontology.org/term/DOID:2378", "evidence": [ { "id": "2378", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2378" } ], "weight": 0.0 }, { "disease_id": "DOID:3021", "name": "acute kidney failure", "description": "", "url": "https://disease-ontology.org/term/DOID:3021", "evidence": [ { "id": "3021", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3021" } ], "weight": 0.0 }, { "disease_id": "DOID:3498", "name": "pancreatic ductal adenocarcinoma", "description": "A pancreatic adenocarcinoma that derives_from pancreatic duct cells.", "url": "https://disease-ontology.org/term/DOID:3498", "evidence": [ { "id": "3498", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3498" } ], "weight": 0.0 }, { "disease_id": "DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.", "url": "https://disease-ontology.org/term/DOID:3908", "evidence": [ { "id": "3908", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ], "weight": 0.0 }, { "disease_id": "DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix.", "url": "https://disease-ontology.org/term/DOID:4362", "evidence": [ { "id": "4362", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4362" } ], "weight": 0.0 }, { "disease_id": "DOID:4448", "name": "macular degeneration", "description": "A retinal degeneration characterized by gradual deterioration of light-sensing cells in the tissues at the back of the eye and has_symptom vision loss.", "url": "https://disease-ontology.org/term/DOID:4448", "evidence": [ { "id": "4448", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4448" } ], "weight": 0.0 }, { 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"disease_id": "DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.", "url": "https://disease-ontology.org/term/DOID:9352", "evidence": [ { "id": "9352", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ], "weight": 0.0 }, { "disease_id": "DOID:9651", "name": "systolic heart failure", "description": "", "url": "https://disease-ontology.org/term/DOID:9651", "evidence": [ { "id": "9651", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9651" } ], "weight": 0.0 }, { "disease_id": "DOID:9669", "name": "senile cataract", "description": "A cataract that is characterized by thickening and loss of transparency of the lens with age progression, caused by a multifactorial etiology related to aging.", "url": "https://disease-ontology.org/term/DOID:9669", "evidence": [ { "id": "9669", "database": "AGR", "url": 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"url": "https://www.alliancegenome.org/disease/DOID:9970" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "P10592", "url": "https://www.uniprot.org/uniprotkb/P10592" } ], "pmid": "" }, { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "P10592", "url": "https://www.uniprot.org/uniprotkb/P10592" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "P10592", "url": "https://www.uniprot.org/uniprotkb/P10592" } ], "pmid": "" }, { "name": "heat shock protein binding", "id": "GO:0031072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031072", "evidence": [ { "database": "UniProtKB", "id": "P10592", "url": 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"https://www.alliancegenome.org/disease/DOID:0112263" } ], "weight": 0.0 }, { "disease_id": "DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate.", "url": "https://disease-ontology.org/term/DOID:10283", "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ], "weight": 0.0 }, { "disease_id": "DOID:10286", "name": "prostate carcinoma", "description": "A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.", "url": "https://disease-ontology.org/term/DOID:10286", "evidence": [ { "id": "10286", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10286" } ], "weight": 0.0 }, { "disease_id": "DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries.", "url": "https://disease-ontology.org/term/DOID:10763", "evidence": [ { 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derives_from epithelial cells.", "url": "https://disease-ontology.org/term/DOID:305", "evidence": [ { "id": "305", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:305" } ], "weight": 0.0 }, { "disease_id": "DOID:3068", "name": "glioblastoma", "description": "A malignant astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes.", "url": "https://disease-ontology.org/term/DOID:3068", "evidence": [ { "id": "3068", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3068" } ], "weight": 0.0 }, { "disease_id": "DOID:3069", "name": "malignant astrocytoma", "description": "A malignant glioma that is has_material_basis_in astrocyte cells, a type of star-shaped glial cell, located in the brain and spinal cord.", "url": "https://disease-ontology.org/term/DOID:3069", "evidence": [ { "id": "3069", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3069" } ], "weight": 0.0 }, { "disease_id": "DOID:3070", "name": "high grade glioma", "description": "A cell type cancer that has_material_basis_in glial cells and is located in brain or located in spine.", "url": "https://disease-ontology.org/term/DOID:3070", "evidence": [ { "id": "3070", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3070" } ], "weight": 0.0 }, { "disease_id": "DOID:3312", "name": "bipolar disorder", "description": "A mood disorder that involves alternating periods of mania and depression.", "url": "https://disease-ontology.org/term/DOID:3312", "evidence": [ { "id": "3312", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3312" } ], "weight": 0.0 }, { "disease_id": "DOID:3748", "name": "esophagus squamous cell carcinoma", "description": "An esophageal carcinoma 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"disease_id": "DOID:12351", "name": "alcoholic hepatitis", "description": "", "url": "https://disease-ontology.org/term/DOID:12351", "evidence": [ { "id": "12351", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12351" } ], "weight": 0.0 }, { "disease_id": "DOID:12365", "name": "malaria", "description": "A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.", "url": "https://disease-ontology.org/term/DOID:12365", "evidence": [ { "id": "12365", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12365" } ], "weight": 0.0 }, { "disease_id": "DOID:13241", "name": "Behcet's disease", "description": "An autoimmune disease that is characterized by mucocutaneous manifestations, including recurrent oral and genital ulcerations, ocular manifestations, especially chronic relapsing uveitis, and systemic vasculitis involving arteries and veins of all sizes.", "url": "https://disease-ontology.org/term/DOID:13241", "evidence": [ { "id": "13241", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13241" } ], "weight": 0.0 }, { "disease_id": "DOID:13413", "name": "hepatic encephalopathy", "description": "A brain disease that is characterized by loss of brain function, the occurrence of confusion, altered level of consciousness, and coma that results when the liver is unable to remove toxins from the blood.", "url": "https://disease-ontology.org/term/DOID:13413", "evidence": [ { "id": "13413", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13413" } ], "weight": 0.0 }, { "disease_id": "DOID:13580", "name": "cholestasis", "description": "A bile duct disease that is characterized by where bile cannot flow from the liver to the duodenum.", "url": "https://disease-ontology.org/term/DOID:13580", "evidence": [ { "id": "13580", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13580" } ], "weight": 0.0 }, { "disease_id": "DOID:1485", "name": "cystic fibrosis", "description": "A syndrome that is characterized by the buildup of thick, sticky mucus that can damage many organs.", "url": "https://disease-ontology.org/term/DOID:1485", "evidence": [ { "id": "1485", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1485" } ], "weight": 0.0 }, { "disease_id": "DOID:1824", "name": "status epilepticus", "description": "", "url": "https://disease-ontology.org/term/DOID:1824", "evidence": [ { "id": "1824", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1824" } ], "weight": 0.0 }, { "disease_id": "DOID:1826", "name": "epilepsy", "description": "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions.", "url": "https://disease-ontology.org/term/DOID:1826", "evidence": [ { "id": "1826", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1826" } ], "weight": 0.0 }, { "disease_id": "DOID:1849", "name": "cannabis dependence", "description": "A drug dependence that involves the continued use of cannabis despite problems related to use of the substance.", "url": "https://disease-ontology.org/term/DOID:1849", "evidence": [ { "id": "1849", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1849" } ], "weight": 0.0 }, { "disease_id": "DOID:1852", "name": "intrahepatic cholestasis", "description": "A cholestasis characterized by impairment of the bile flow caused by obstruction located_in liver.", "url": "https://disease-ontology.org/term/DOID:1852", "evidence": [ { "id": "1852", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1852" } ], "weight": 0.0 }, { "disease_id": "DOID:1949", "name": "cholecystitis", "description": "A cholangitis that is characterized by an inflammation that is located in the gallbladder.", "url": "https://disease-ontology.org/term/DOID:1949", "evidence": [ { "id": "1949", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1949" } ], "weight": 0.0 }, { "disease_id": "DOID:2154", "name": "nephroblastoma", "description": "A kidney cancer that affects the kidneys and typically occuring in children.", "url": "https://disease-ontology.org/term/DOID:2154", "evidence": [ { "id": "2154", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2154" } ], "weight": 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"https://www.alliancegenome.org/disease/DOID:2559" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:2917", "name": "cryoglobulinemia", "description": "A hypersensitivity reaction type IV disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.", "url": "https://disease-ontology.org/term/DOID:2917", "evidence": [ { "id": "2917", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2917" } ], "weight": 0.0 }, { "disease_id": "DOID:2957", "name": "pulmonary tuberculosis", "description": "A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis.", "url": "https://disease-ontology.org/term/DOID:2957", "evidence": [ { "id": "2957", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2957" } ], "weight": 0.0 }, { "disease_id": "DOID:2987", "name": "familial Mediterranean fever", "description": "An autoinflammatory disease characterized by recurrent episodes of fever and acute inflammation of the membranes lining the abdomen, joints and lungs; that has_material_basis_in mutations in the MEFV gene, which encodes the protein pyrin.", "url": "https://disease-ontology.org/term/DOID:2987", "evidence": [ { "id": "2987", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2987" } ], "weight": 0.0 }, { "disease_id": "DOID:3008", "name": "invasive ductal carcinoma", "description": "A breast ductal carcinoma that is characterized by infiltration into the fibrous or fatty tissue of the breast outside of the duct where it originated.", "url": "https://disease-ontology.org/term/DOID:3008", "evidence": [ { "id": "3008", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3008" } ], "weight": 0.0 }, { "disease_id": "DOID:3070", "name": "high grade glioma", "description": "A cell type cancer that has_material_basis_in glial cells and is located in brain or located in spine.", "url": "https://disease-ontology.org/term/DOID:3070", "evidence": [ { "id": "3070", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3070" } ], "weight": 0.0 }, { "disease_id": "DOID:3328", "name": "temporal lobe epilepsy", "description": "A focal epilepsy that is characterized by recurrent, unprovoked focal seizures that originate in the temporal lobe of the brain and last about one or two minutes.", "url": "https://disease-ontology.org/term/DOID:3328", "evidence": [ { "id": "3328", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3328" } ], "weight": 0.0 }, { "disease_id": "DOID:3602", "name": "toxic encephalopathy", "description": "A nervous system disease that results from exposure to neurotoxicants and is characterized by an altered mental status, memory loss, and visual problems.", "url": "https://disease-ontology.org/term/DOID:3602", "evidence": [ { "id": "3602", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3602" } ], "weight": 0.0 }, { "disease_id": "DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.", "url": "https://disease-ontology.org/term/DOID:3908", "evidence": [ { "id": "3908", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ], "weight": 0.0 }, { "disease_id": "DOID:4450", "name": "renal cell carcinoma", "description": "A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney.", "url": "https://disease-ontology.org/term/DOID:4450", "evidence": [ { "id": "4450", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4450" } ], "weight": 0.0 }, { "disease_id": "DOID:4481", "name": "allergic rhinitis", "description": "A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.", "url": "https://disease-ontology.org/term/DOID:4481", "evidence": [ { "id": "4481", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4481" } ], "weight": 0.0 }, { "disease_id": "DOID:5082", "name": "liver cirrhosis", "description": "", "url": "https://disease-ontology.org/term/DOID:5082", "evidence": [ { "id": "5082", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5082" } ], "weight": 0.0 }, { "disease_id": "DOID:526", "name": "human immunodeficiency virus infectious disease", "description": "A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 (Lentivirus humimdef1) or Human immunodeficiency virus 2 (Lentivirus humimdef2), which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.", "url": "https://disease-ontology.org/term/DOID:526", "evidence": [ { "id": "526", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:526" } ], "weight": 0.0 }, { "disease_id": "DOID:635", "name": "acquired immunodeficiency syndrome", "description": "A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per microliter of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 (Lentivirus humimdef1) or Human immunodeficiency virus 2 (Lentivirus humimdef2), which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS.", "url": "https://disease-ontology.org/term/DOID:635", "evidence": [ { "id": "635", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:635" } ], "weight": 0.0 }, { "disease_id": "DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.", "url": "https://disease-ontology.org/term/DOID:684", "evidence": [ { "id": "684", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:684" } ], "weight": 0.0 }, { "disease_id": "DOID:783", "name": "end stage renal disease", "description": "A chronic kidney disease is characterized by non-functioning kidneys, as the final stage in chronic kidney disease.", "url": "https://disease-ontology.org/term/DOID:783", "evidence": [ { "id": "783", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:783" } ], "weight": 0.0 }, { "disease_id": "DOID:8552", "name": "chronic myeloid leukemia", "description": "A myeloid leukemia that is characterized by over production of white blood cells.", "url": "https://disease-ontology.org/term/DOID:8552", "evidence": [ { "id": "8552", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8552" } ], "weight": 0.0 }, { "disease_id": "DOID:8577", "name": "ulcerative colitis", "description": "A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores.", "url": "https://disease-ontology.org/term/DOID:8577", "evidence": [ { "id": "8577", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8577" } ], "weight": 0.0 }, { "disease_id": "DOID:8778", "name": "Crohn's disease", "description": "An intestinal disease that involves inflammation located_in intestine.", "url": "https://disease-ontology.org/term/DOID:8778", "evidence": [ { "id": "8778", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8778" } ], "weight": 0.0 }, { "disease_id": "DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.", "url": "https://disease-ontology.org/term/DOID:9352", "evidence": [ { "id": "9352", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ], "weight": 0.0 }, { "disease_id": "DOID:9952", "name": "acute lymphoblastic leukemia", "description": "A acute leukemia that is characterized by over production of lymphoblasts.", "url": "https://disease-ontology.org/term/DOID:9952", "evidence": [ { "id": "9952", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9952" } ], "weight": 0.0 }, { "disease_id": "DOID:9974", "name": "drug dependence", "description": "A substance dependence that involves the continued use of drugs despite problems related to use of the substance.", "url": 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Complete loss of catalytic activity.", "evidence": [ { "database": "UniProtKB", "id": "P25694", "url": "https://www.uniprot.org/uniprotkb/P25694" }, { "database": "PubMed", "id": "21454554", "url": "https://glygen.org/publication/PubMed/21454554" } ] } ] }, { "uniprot_canonical_ac": "P25694-1", "start_pos": "315", "end_pos": "315", "site_lbl": "Glu315", "weight": 0.0, "mutagenesis": [ { "sequence_org": "E", "sequence_mut": "A", "comment": "Moderate reduction in growth rate.", "evidence": [ { "database": "UniProtKB", "id": "P25694", "url": "https://www.uniprot.org/uniprotkb/P25694" }, { "database": "PubMed", "id": "21454554", "url": "https://glygen.org/publication/PubMed/21454554" } ] }, { "sequence_org": "E", "sequence_mut": "D", "comment": "Severe loss of catalytic activity without affecting cooperativity between the 2 ATP-binding regions. 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Decreases cell population growth.", "evidence": [ { "database": "UniProtKB", "id": "P32481", "url": "https://www.uniprot.org/uniprotkb/P32481" }, { "database": "PubMed", "id": "35031321", "url": "https://glygen.org/publication/PubMed/35031321" } ] } ] }, { "uniprot_canonical_ac": "P32481-1", "start_pos": "490", "end_pos": "490", "site_lbl": "Pro490", "weight": 0.0, "mutagenesis": [ { "sequence_org": "P", "sequence_mut": "S", "comment": "Mildly impairs eIF2 complex function.", "evidence": [ { "database": "UniProtKB", "id": "P32481", "url": "https://www.uniprot.org/uniprotkb/P32481" }, { "database": "PubMed", "id": "30878599", "url": "https://glygen.org/publication/PubMed/30878599" } ] } ] }, { "uniprot_canonical_ac": "P32481-1", "start_pos": "504", "end_pos": "504", "site_lbl": "Arg504", "weight": 0.0, "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "A", "comment": "Disrupts binding to CDC123.", "evidence": [ { "database": "UniProtKB", "id": "P32481", "url": "https://www.uniprot.org/uniprotkb/P32481" }, { "database": "PubMed", "id": "26211610", "url": "https://glygen.org/publication/PubMed/26211610" } ] } ] }, { "uniprot_canonical_ac": "P32481-1", "start_pos": "509", "end_pos": "509", "site_lbl": "Trp509", "weight": 0.0, "mutagenesis": [ { "sequence_org": "W", "sequence_mut": "A", "comment": "Disrupts binding to CDC123.", "evidence": [ { "database": "UniProtKB", "id": "P32481", "url": "https://www.uniprot.org/uniprotkb/P32481" }, { "database": "PubMed", "id": "26211610", "url": "https://glygen.org/publication/PubMed/26211610" } ] } ] } ], "record_id": "P32481-1" }, { "uniprot_canonical_ac": "P32485-1", "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P32485", "url": "https://www.uniprot.org/uniprotkb/P32485" } ], "common_name": "Baker's yeast", "glygen_name": "Yeast", "reference_species": "Saccharomyces cerevisiae S288C [559292]" } ], "length": 435, "chemical_mass": 48858.0, "gene_names": "HOG1;HOG1;L2931;L9354.2;SSK3", "protein_name": "Mitogen-activated protein kinase HOG1", "disease": [ { "disease_id": "DOID:0050860", "name": "colorectal adenoma", "description": "An intestinal benign neoplasm that has_material_basis_in epithelial tissue of glandular origin and is located_in colon and located_in rectum.", "url": "https://disease-ontology.org/term/DOID:0050860", "evidence": [ { "id": "0050860", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050860" } ], "weight": 0.0 }, { "disease_id": "DOID:0050861", "name": "colorectal adenocarcinoma", "description": "A colorectal carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:0050861", "evidence": [ { "id": "0050861", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050861" } ], "weight": 0.0 }, { "disease_id": "DOID:0051061", "name": "stroke", "description": "A cerebrovascular disease that is characterized by disruption of blood flow to the brain resulting in damage to brain cells due to a lack of oxygen.", "url": "https://disease-ontology.org/term/DOID:0051061", "evidence": [ { "id": "0051061", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0051061" } ], "weight": 0.0 }, { "disease_id": "DOID:0060071", "name": "pre-malignant neoplasm", "description": "A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer.", "url": "https://disease-ontology.org/term/DOID:0060071", "evidence": [ { "id": "0060071", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060071" } ], "weight": 0.0 }, { "disease_id": "DOID:0080199", "name": "colorectal carcinoma", "description": "A colorectal cancer that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa.", "url": "https://disease-ontology.org/term/DOID:0080199", "evidence": [ { "id": "0080199", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080199" } ], "weight": 0.0 }, { "disease_id": "DOID:0080208", "name": "metabolic dysfunction-associated steatotic liver disease", "description": "A steatotic liver disease characterized by at least one of five specified cardiometabolic risk factors and no other discernible cause with normal to no alcohol use. The five cardiometabolic risk factors are: (1) higher than normal body mass index or waist circumference; (2) higher than normal serum glucose or glycated hemoglobin level, or type 2 diabetes; (3) higher than normal blood pressure or hypertensive treatment; (4) higher than normal plasma triglycerides or lipid lowering treatment; and (5) lower than normal plasma high-density lipoprotein cholesterol.", "url": "https://disease-ontology.org/term/DOID:0080208", "evidence": [ { "id": "0080208", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080208" } ], "weight": 0.0 }, { "disease_id": "DOID:0080855", "name": "Parkinsonism", "description": "A movement disorder that is characterized by disturbances of balance, gait and posture.", "url": "https://disease-ontology.org/term/DOID:0080855", "evidence": [ { "id": "0080855", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080855" } ], "weight": 0.0 }, { "disease_id": "DOID:10652", "name": "Alzheimer's 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"https://www.alliancegenome.org/disease/DOID:10763" } ], "weight": 0.0 }, { "disease_id": "DOID:11476", "name": "osteoporosis", "description": "A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength.", "url": "https://disease-ontology.org/term/DOID:11476", "evidence": [ { "id": "11476", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11476" } ], "weight": 0.0 }, { "disease_id": "DOID:13949", "name": "interstitial cystitis", "description": "", "url": "https://disease-ontology.org/term/DOID:13949", "evidence": [ { "id": "13949", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13949" } ], "weight": 0.0 }, { "disease_id": "DOID:14330", "name": "Parkinson's disease", "description": "A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.", "url": "https://disease-ontology.org/term/DOID:14330", "evidence": [ { "id": "14330", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14330" } ], "weight": 0.0 }, { "disease_id": "DOID:1574", "name": "alcohol use disorder", "description": "A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.", "url": "https://disease-ontology.org/term/DOID:1574", "evidence": [ { "id": "1574", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1574" } ], "weight": 0.0 }, { "disease_id": "DOID:1984", "name": "rectal benign neoplasm", "description": "An intestinal benign neoplasm located_in the rectum.", "url": "https://disease-ontology.org/term/DOID:1984", "evidence": [ { "id": "1984", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1984" } ], "weight": 0.0 }, { "disease_id": "DOID:1993", "name": "rectum cancer", "description": "A colorectal cancer that is located_in the rectum.", "url": "https://disease-ontology.org/term/DOID:1993", "evidence": [ { "id": "1993", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1993" } ], "weight": 0.0 }, { "disease_id": "DOID:2058", "name": "chronic mucocutaneous candidiasis", "description": "A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp.", "url": "https://disease-ontology.org/term/DOID:2058", "evidence": [ { "id": "2058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2058" } ], "weight": 0.0 }, { "disease_id": "DOID:219", "name": "colon cancer", "description": "A colorectal cancer that is located_in the colon.", "url": "https://disease-ontology.org/term/DOID:219", "evidence": [ { "id": "219", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:219" } ], "weight": 0.0 }, { "disease_id": "DOID:2316", "name": "brain ischemia", "description": "An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand.", "url": "https://disease-ontology.org/term/DOID:2316", "evidence": [ { "id": "2316", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2316" } ], "weight": 0.0 }, { "disease_id": "DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:3717", "name": "gastric adenocarcinoma", "description": "A stomach carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:3717", "evidence": [ { "id": "3717", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3717" } ], "weight": 0.0 }, { "disease_id": "DOID:4074", "name": "pancreatic adenocarcinoma", "description": "A pancreatic carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:4074", "evidence": [ { "id": "4074", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4074" } ], "weight": 0.0 }, { "disease_id": "DOID:4780", "name": "anti-basement membrane glomerulonephritis", "description": "A Goodpasture syndrome that is characterized by damage to only kidney capillaries.", "url": "https://disease-ontology.org/term/DOID:4780", "evidence": [ { "id": "4780", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4780" } ], "weight": 0.0 }, { "disease_id": "DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.", "url": "https://disease-ontology.org/term/DOID:5844", "evidence": [ { "id": "5844", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ], "weight": 0.0 }, { "disease_id": "DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.", "url": "https://disease-ontology.org/term/DOID:684", "evidence": [ { "id": "684", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:684" } ], "weight": 0.0 }, { "disease_id": "DOID:7693", "name": "abdominal aortic aneurysm", "description": "An aortic aneurysm that is located_in the abdominal aorta.", "url": "https://disease-ontology.org/term/DOID:7693", "evidence": [ { "id": "7693", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:7693" } ], "weight": 0.0 }, { "disease_id": "DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum.", "url": "https://disease-ontology.org/term/DOID:9256", "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ], "weight": 0.0 }, { "disease_id": "DOID:9261", "name": "nasopharynx carcinoma", "description": "A pharynx cancer that is located in the nasopharynx, the uppermost region of the pharynx or throat, where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.", "url": "https://disease-ontology.org/term/DOID:9261", "evidence": [ { "id": "9261", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9261" } ], "weight": 0.0 }, { "disease_id": "DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.", "url": "https://disease-ontology.org/term/DOID:9352", "evidence": [ { "id": "9352", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ], "weight": 0.0 }, { "disease_id": "DOID:9743", "name": "diabetic neuropathy", "description": "", "url": "https://disease-ontology.org/term/DOID:9743", "evidence": [ { "id": "9743", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9743" } ], "weight": 0.0 } ], "biological_process": [ { "name": "regulation of nuclear cell cycle DNA replication", "id": "GO:0033262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033262", "evidence": [ { "database": "UniProtKB", "id": "P32485", "url": "https://www.uniprot.org/uniprotkb/P32485" } ], "pmid": "" }, { "name": "osmosensory signaling pathway", "id": "GO:0007231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007231", "evidence": [ { "database": "UniProtKB", "id": "P32485", "url": "https://www.uniprot.org/uniprotkb/P32485" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "P32485", "url": "https://www.uniprot.org/uniprotkb/P32485" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "P32485", "url": "https://www.uniprot.org/uniprotkb/P32485" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", 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"id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "P32485", "url": "https://www.uniprot.org/uniprotkb/P32485" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "P32485", "url": "https://www.uniprot.org/uniprotkb/P32485" } ], "pmid": "" }, { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "P32485", "url": "https://www.uniprot.org/uniprotkb/P32485" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "P32485", "url": "https://www.uniprot.org/uniprotkb/P32485" } ], "pmid": "" }, { "name": "MAP kinase activity", "id": "GO:0004707", "url": 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"protein_name": "Actin", "disease": [ { "disease_id": "DOID:0050827", "name": "rheumatic heart disease", "description": "A heart valve disease that is characterized by repeated inflammation with fibrinous repair caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords.", "url": "https://disease-ontology.org/term/DOID:0050827", "evidence": [ { "id": "0050827", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050827" } ], "weight": 0.0 }, { "disease_id": "DOID:0060610", "name": "megacystis-microcolon-intestinal hypoperistalsis syndrome", "description": "A syndrome that is characterized by marked dilatation of the bladder and microcolon and decreased intestinal peristalsis.", "url": "https://disease-ontology.org/term/DOID:0060610", "evidence": [ { "id": "0060610", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060610" } ], "weight": 0.0 }, { "disease_id": "DOID:0070585", "name": "spermatogenic failure 86", "description": "A spermatogenic failure characterized by acrosomal defects of the spermatozoa, resulting in oocyte activation deficiency and fertilization failure, that has_material_basis_in homozygous or compound heterozygous mutation in the ACTL7A gene on chromosome 9q31.3.", "url": "https://disease-ontology.org/term/DOID:0070585", "evidence": [ { "id": "0070585", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070585" } ], "weight": 0.0 }, { "disease_id": "DOID:0080208", "name": "metabolic dysfunction-associated steatotic liver disease", "description": "A steatotic liver disease characterized by at least one of five specified cardiometabolic risk factors and no other discernible cause with normal to no alcohol use. The five cardiometabolic risk factors are: (1) higher than normal body mass index or waist circumference; (2) higher than normal serum glucose or glycated hemoglobin level, or type 2 diabetes; (3) higher than normal blood pressure or hypertensive treatment; (4) higher than normal plasma triglycerides or lipid lowering treatment; and (5) lower than normal plasma high-density lipoprotein cholesterol.", "url": "https://disease-ontology.org/term/DOID:0080208", "evidence": [ { "id": "0080208", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080208" } ], "weight": 0.0 }, { "disease_id": "DOID:0080685", "name": "aortic dissection", "description": "An aortic disease that is characterized by tearing of the intimal layer of the aorta resulting in separation of the layers of the aortic wall.", "url": "https://disease-ontology.org/term/DOID:0080685", "evidence": [ { "id": "0080685", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080685" } ], "weight": 0.0 }, { "disease_id": "DOID:0081112", "name": "Baraitser-Winter syndrome 1", "description": "A Baraitser-Winter syndrome that has_material_basis_in heterozygous mutation in the ACTB gene on chromosome 7p22. A subset of patients have a larger deletion of chromosome 7p22 including the ACTB gene and additional variable genes, consistent with a contiguous gene deletion syndrome.", "url": "https://disease-ontology.org/term/DOID:0081112", "evidence": [ { "id": "0081112", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0081112" } ], "weight": 0.0 }, { "disease_id": "DOID:0081113", "name": "Baraitser-Winter syndrome 2", "description": "A Baraitser-Winter syndrome that has_material_basis_in heterozygous mutation in the ACTG1 gene on chromosome 17q25.", "url": "https://disease-ontology.org/term/DOID:0081113", "evidence": [ { "id": "0081113", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0081113" } ], "weight": 0.0 }, { "disease_id": "DOID:0081339", "name": "congenital myopathy 2B", "description": "A congenital myopathy that is characterized by severe hypotonia with lack of spontaneous movements and respiratory insufficiency, usually leading to death in infancy or early childhood and that has_material_basis_in homozygous or compound heterozygous mutation in the ACTA1 gene on chromosome 1q42.", "url": "https://disease-ontology.org/term/DOID:0081339", "evidence": [ { "id": "0081339", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0081339" } ], "weight": 0.0 }, { "disease_id": "DOID:0081340", "name": "congenital myopathy 2C", "description": "A congenital myopathy that is characterized by severe congenital weakness usually resulting in death from respiratory failure in the first year or so of life and that has_material_basis_in heterozygous mutation in the ACTA1 gene on chromosome 1q42. Heterozygous mutation in the ACTA1 gene can also cause autosomal dominant typical congenital myopathy-2A (CMYP2A). Biallelic mutation in the ACTA1 gene causes autosomal recessive severe infantile congenital myopathy-2B (CMYP2B).", "url": "https://disease-ontology.org/term/DOID:0081340", "evidence": [ { "id": "0081340", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0081340" } ], "weight": 0.0 }, { "disease_id": "DOID:0110110", "name": "atrial heart septal defect 5", "description": "An atrial heart septal defect type 5 that has_material_basis_in heterozygous mutation in the ACTC1 gene on chromosome 15q14.", "url": "https://disease-ontology.org/term/DOID:0110110", "evidence": [ { "id": "0110110", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110110" } ], "weight": 0.0 }, { "disease_id": "DOID:0110317", "name": "hypertrophic cardiomyopathy 11", "description": "A familial hypertrophic cardiomyopathy that has_material_basis_in heterozygous mutation in the ACTC1 gene on chromosome 15q14.", "url": "https://disease-ontology.org/term/DOID:0110317", "evidence": [ { "id": "0110317", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110317" } ], "weight": 0.0 }, { "disease_id": "DOID:0110456", "name": "dilated cardiomyopathy 1R", "description": "A dilated cardiomyopathy that has_material_basis_in mutation in the ACTC1 gene on chromosome 15q14.", "url": "https://disease-ontology.org/term/DOID:0110456", "evidence": [ { "id": "0110456", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110456" } ], "weight": 0.0 }, { "disease_id": "DOID:0110550", "name": "autosomal dominant nonsyndromic deafness 20", "description": "An autosomal dominant nonsyndromic deafness that is characterized by postlingual onset with high frequency progressive hearing loss and has_material_basis_in mutation in the ACTG1 gene on chromosome 17q25.", "url": "https://disease-ontology.org/term/DOID:0110550", "evidence": [ { "id": "0110550", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110550" } ], "weight": 0.0 }, { "disease_id": "DOID:0110927", "name": "nemaline myopathy 3", "description": "A nemaline myopathy that has_material_basis_in homozygous, compound heterozygous, or heterozygous mutation in the ACTA1 gene on chromosome 1q42.", "url": "https://disease-ontology.org/term/DOID:0110927", "evidence": [ { "id": "0110927", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110927" } ], "weight": 0.0 }, { "disease_id": "DOID:10486", "name": "intestinal atresia", "description": "", "url": "https://disease-ontology.org/term/DOID:10486", "evidence": [ { "id": "10486", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10486" } ], "weight": 0.0 }, { "disease_id": "DOID:1059", "name": "intellectual disability", "description": "A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills.", "url": "https://disease-ontology.org/term/DOID:1059", "evidence": [ { "id": "1059", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1059" } ], "weight": 0.0 }, { "disease_id": "DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries.", "url": "https://disease-ontology.org/term/DOID:10763", "evidence": [ { "id": "10763", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ], "weight": 0.0 }, { "disease_id": "DOID:10881", "name": "hand, foot and mouth disease", "description": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in Enterovirus A (Enterovirus alphacoxsackie), which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.", "url": "https://disease-ontology.org/term/DOID:10881", "evidence": [ { "id": "10881", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10881" } ], "weight": 0.0 }, { "disease_id": "DOID:11984", "name": "hypertrophic cardiomyopathy", "description": "An intrinsic cardiomyopathy that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause.", "url": "https://disease-ontology.org/term/DOID:11984", "evidence": [ { "id": "11984", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11984" } ], "weight": 0.0 }, { "disease_id": "DOID:12336", "name": "male infertility", "description": "", "url": "https://disease-ontology.org/term/DOID:12336", "evidence": [ { "id": "12336", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12336" } ], "weight": 0.0 }, { "disease_id": "DOID:12930", "name": "dilated cardiomyopathy", "description": "An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently.", "url": "https://disease-ontology.org/term/DOID:12930", "evidence": [ { "id": "12930", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12930" } ], "weight": 0.0 }, { "disease_id": "DOID:13099", "name": "Moyamoya disease", "description": "A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. Blood flow is blocked by the constriction and also by blood clots.", "url": "https://disease-ontology.org/term/DOID:13099", "evidence": [ { "id": "13099", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13099" } ], "weight": 0.0 }, { "disease_id": "DOID:13832", "name": "patent ductus arteriosus", "description": "", "url": "https://disease-ontology.org/term/DOID:13832", "evidence": [ { "id": "13832", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13832" } ], "weight": 0.0 }, { "disease_id": "DOID:14004", "name": "thoracic aortic aneurysm", "description": "An aortic aneurysm that is located_in the thoracic aorta.", "url": "https://disease-ontology.org/term/DOID:14004", "evidence": [ { "id": "14004", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14004" } ], "weight": 0.0 }, { "disease_id": "DOID:14018", "name": "alcoholic liver cirrhosis", "description": "", "url": "https://disease-ontology.org/term/DOID:14018", "evidence": [ { "id": "14018", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14018" } ], "weight": 0.0 }, { "disease_id": "DOID:1574", "name": "alcohol use disorder", "description": "A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.", "url": "https://disease-ontology.org/term/DOID:1574", "evidence": [ { "id": "1574", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1574" } ], "weight": 0.0 }, { "disease_id": "DOID:1588", "name": "thrombocytopenia", "description": "A blood platelet disease that is characterized by low a platelet count in the blood.", "url": "https://disease-ontology.org/term/DOID:1588", "evidence": [ { "id": "1588", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1588" } ], "weight": 0.0 }, { "disease_id": "DOID:3191", "name": "nemaline myopathy", "description": "A congenital myopathy characterized by generally non-progressive muscle weakness of varying severity and problems with the tone and contraction of skeletal muscles. The muscle cells contain abnormal clumps of threadlike material called nemaline bodies.", "url": "https://disease-ontology.org/term/DOID:3191", "evidence": [ { "id": "3191", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3191" } ], "weight": 0.0 }, { "disease_id": "DOID:3328", "name": "temporal lobe epilepsy", "description": "A focal epilepsy that is characterized by recurrent, unprovoked focal seizures that originate in the temporal lobe of the brain and last about one or two minutes.", "url": "https://disease-ontology.org/term/DOID:3328", "evidence": [ { "id": "3328", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3328" } ], "weight": 0.0 }, { "disease_id": "DOID:4006", "name": "bladder urothelial carcinoma", "description": "A bladder carcinoma that has_material_basis_in transitional cells located_in the lining of the bladder.", "url": "https://disease-ontology.org/term/DOID:4006", "evidence": [ { "id": "4006", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4006" } ], "weight": 0.0 }, { "disease_id": "DOID:422", "name": "congenital structural myopathy", "description": "A myopathy that is characterized by hypotonia, muscle weakness, and delayed development of motor skills.", "url": "https://disease-ontology.org/term/DOID:422", "evidence": [ { "id": "422", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:422" } ], "weight": 0.0 }, { "disease_id": "DOID:423", "name": "myopathy", "description": "A muscular disease in which the muscle fibers do not function resulting in muscular weakness.", "url": "https://disease-ontology.org/term/DOID:423", "evidence": [ { "id": "423", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:423" } ], "weight": 0.0 }, { "disease_id": "DOID:4977", "name": "lymphedema", "description": "A lymphatic system disease that is characterized by the abnormal accumulation of lymph fluid in the body's tissues, leading to swelling.", "url": "https://disease-ontology.org/term/DOID:4977", "evidence": [ { "id": "4977", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4977" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "structural constituent of cytoskeleton", "id": "GO:0005200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005200", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "actin filament", "id": "GO:0005884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005884", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "Ino80 complex", "id": "GO:0031011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031011", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "NuA4 histone acetyltransferase complex", "id": "GO:0035267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035267", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "Swr1 complex", "id": "GO:0000812", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000812", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "actin filament bundle", "id": "GO:0032432", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032432", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "actin cortical patch", "id": "GO:0030479", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030479", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "cellular bud neck contractile ring", "id": "GO:0000142", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000142", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" } ], "biological_process": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "protein secretion", "id": "GO:0009306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009306", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "establishment of cell polarity", "id": "GO:0030010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030010", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "vacuole inheritance", "id": "GO:0000011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000011", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "ascospore wall assembly", "id": "GO:0030476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030476", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": "https://www.uniprot.org/uniprotkb/P60010" } ], "pmid": "" }, { "name": "mitotic actomyosin contractile ring contraction", "id": "GO:1902404", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902404", "evidence": [ { "database": "UniProtKB", "id": "P60010", "url": 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Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:9538", "name": "multiple myeloma", "description": "A myeloid neoplasm that is located_in the plasma cells in bone marrow.", "url": "https://disease-ontology.org/term/DOID:9538", "evidence": [ { "id": "9538", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9538" } ], "weight": 0.0 } ], "biological_process": [ { "name": "subtelomeric heterochromatin formation", "id": "GO:0031509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031509", "evidence": [ { "database": "UniProtKB", "id": "Q04437", "url": "https://www.uniprot.org/uniprotkb/Q04437" } ], "pmid": "" }, { "name": "telomere maintenance", "id": "GO:0000723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000723", "evidence": [ { "database": "UniProtKB", "id": "Q04437", "url": "https://www.uniprot.org/uniprotkb/Q04437" } ], "pmid": "" }, { "name": "double-strand break repair via nonhomologous end joining", "id": "GO:0006303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006303", "evidence": [ { "database": "UniProtKB", "id": "Q04437", "url": "https://www.uniprot.org/uniprotkb/Q04437" } ], "pmid": "" }, { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "Q04437", "url": "https://www.uniprot.org/uniprotkb/Q04437" } ], "pmid": "" }, { "name": "double-strand break repair via homologous recombination", "id": "GO:0000724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000724", "evidence": [ { "database": "UniProtKB", "id": "Q04437", "url": "https://www.uniprot.org/uniprotkb/Q04437" } ], "pmid": "" }, { "name": "recombinational repair", "id": "GO:0000725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000725", "evidence": [ { "database": "UniProtKB", "id": "Q04437", "url": "https://www.uniprot.org/uniprotkb/Q04437" } ], "pmid": "" }, { "name": "establishment of protein-containing complex localization to telomere", "id": "GO:0097695", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097695", "evidence": [ { "database": "UniProtKB", "id": "Q04437", "url": "https://www.uniprot.org/uniprotkb/Q04437" } ], "pmid": "" }, { "name": "protein localization to chromosome", "id": "GO:0034502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034502", "evidence": [ { "database": "UniProtKB", "id": "Q04437", "url": "https://www.uniprot.org/uniprotkb/Q04437" } ], "pmid": "" }, { "name": "donor selection", "id": "GO:0007535", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007535", "evidence": [ { "database": "UniProtKB", "id": "Q04437", "url": "https://www.uniprot.org/uniprotkb/Q04437" } ], "pmid": "" } ], "molecular_function": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q04437", "url": "https://www.uniprot.org/uniprotkb/Q04437" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q04437", "url": "https://www.uniprot.org/uniprotkb/Q04437" } ], "pmid": "" }, { "name": "damaged DNA binding", "id": "GO:0003684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003684", "evidence": [ { "database": "UniProtKB", "id": "Q04437", "url": "https://www.uniprot.org/uniprotkb/Q04437" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q04437", "url": "https://www.uniprot.org/uniprotkb/Q04437" } ], "pmid": "" }, { "name": "telomeric DNA binding", "id": "GO:0042162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042162", "evidence": [ { "database": "UniProtKB", "id": "Q04437", "url": "https://www.uniprot.org/uniprotkb/Q04437" } ], "pmid": "" }, { "name": "DNA helicase activity", "id": "GO:0003678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003678", "evidence": [ { "database": "UniProtKB", "id": "Q04437", "url": "https://www.uniprot.org/uniprotkb/Q04437" } ], "pmid": "" }, { "name": "telomerase RNA binding", "id": "GO:0070034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070034", "evidence": [ { "database": "UniProtKB", "id": "Q04437", "url": "https://www.uniprot.org/uniprotkb/Q04437" } ], "pmid": "" } ], "cellular_component": [ { "name": "chromosome, telomeric region", "id": "GO:0000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "evidence": [ { "database": "UniProtKB", "id": "Q04437", "url": "https://www.uniprot.org/uniprotkb/Q04437" } ], "pmid": "" }, { "name": "Ku70:Ku80 complex", "id": "GO:0043564", "url": 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"kinase_gene_name": "", "evidence": [ { "database": "SGD", "id": "S000004712", "url": "https://www.yeastgenome.org/locus/S000004712" }, { "database": "iPTMnet", "id": "Q04437", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04437" }, { "database": "PubMed", "id": "33491328", "url": "https://glygen.org/publication/PubMed/33491328" } ] } ] }, { "uniprot_canonical_ac": "Q04437-1", "start_pos": "595", "end_pos": "595", "site_lbl": "Ser595", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "SGD", "id": "S000004712", "url": "https://www.yeastgenome.org/locus/S000004712" }, { "database": "iPTMnet", "id": "Q04437", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q04437" }, { "database": "PubMed", "id": "33491328", "url": "https://glygen.org/publication/PubMed/33491328" } ] } ] } ], "record_id": "Q04437-1" }, { "uniprot_canonical_ac": "Q04439-1", "species": [ { "name": "Saccharomyces 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"url": "https://www.uniprot.org/uniprotkb/Q04439" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q04439", "url": "https://www.uniprot.org/uniprotkb/Q04439" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q04439", "url": "https://www.uniprot.org/uniprotkb/Q04439" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "Q04439", "url": "https://www.uniprot.org/uniprotkb/Q04439" } ], "pmid": "" }, { "name": "cell periphery", "id": "GO:0071944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071944", "evidence": [ { "database": "UniProtKB", "id": "Q04439", "url": "https://www.uniprot.org/uniprotkb/Q04439" } ], "pmid": "" }, { "name": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0043332", "evidence": [ { "database": "UniProtKB", "id": "Q04439", "url": "https://www.uniprot.org/uniprotkb/Q04439" } ], "pmid": "" } ], "molecular_function": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q04439", "url": "https://www.uniprot.org/uniprotkb/Q04439" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "Q04439", "url": "https://www.uniprot.org/uniprotkb/Q04439" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q04439", "url": "https://www.uniprot.org/uniprotkb/Q04439" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": 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of the function of the heart muscle.", "url": "https://disease-ontology.org/term/DOID:0050700", "evidence": [ { "id": "0050700", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050700" } ], "weight": 0.0 }, { "disease_id": "DOID:0060193", "name": "amyotrophic lateral sclerosis type 1", "description": "An amyotrophic lateral sclerosis that has_material_basis_in mutation in the SOD1 gene on chromosome 21. The most common type of familial ALS.", "url": "https://disease-ontology.org/term/DOID:0060193", "evidence": [ { "id": "0060193", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060193" } ], "weight": 0.0 }, { "disease_id": "DOID:0070508", "name": "metabolic dysfunction and alcohol associated liver disease", "description": "A steatotic liver disease characterized by at least one of five specified cardiometabolic risk factors and elevated alcohol consumption. This disease is distinguished from MASLD by increased alcohol consumption and from ALD by the evidence of one or more of the specified cardiometabolic risk factors. The five cardiometabolic risk factors are: (1) higher than normal body mass index or waist circumference; (2) higher than normal serum glucose or glycated hemoglobin level, or type 2 diabetes; (3) higher than normal blood pressure or hypertensive treatment; (4) higher than normal plasma triglycerides or lipid lowering treatment; and (5) lower than normal plasma high-density lipoprotein cholesterol.", "url": "https://disease-ontology.org/term/DOID:0070508", "evidence": [ { "id": "0070508", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070508" } ], "weight": 0.0 }, { "disease_id": "DOID:0080208", "name": "metabolic dysfunction-associated steatotic liver disease", "description": "A steatotic liver disease characterized by at least one of five specified cardiometabolic risk factors and no other discernible cause with normal to no alcohol use. The five cardiometabolic risk factors are: (1) higher than normal body mass index or waist circumference; (2) higher than normal serum glucose or glycated hemoglobin level, or type 2 diabetes; (3) higher than normal blood pressure or hypertensive treatment; (4) higher than normal plasma triglycerides or lipid lowering treatment; and (5) lower than normal plasma high-density lipoprotein cholesterol.", "url": "https://disease-ontology.org/term/DOID:0080208", "evidence": [ { "id": "0080208", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080208" } ], "weight": 0.0 }, { "disease_id": "DOID:0080547", "name": "metabolic dysfunction-associated steatohepatitis", "description": "A metabolic dysfunction-associated steatotic liver disease characterized by the presence of inflammation with hepatocyte injury such as ballooning, with or without fibrosis.", "url": "https://disease-ontology.org/term/DOID:0080547", "evidence": [ { "id": "0080547", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080547" } ], "weight": 0.0 }, { "disease_id": "DOID:10003", "name": "sensorineural hearing loss", "description": "An inner ear disease that is characterized by hearing loss resulting from damage to the cochlea, auditory nerve and/or brainstem.", "url": "https://disease-ontology.org/term/DOID:10003", "evidence": [ { "id": "10003", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10003" } ], "weight": 0.0 }, { "disease_id": "DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach.", "url": "https://disease-ontology.org/term/DOID:10534", "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ], "weight": 0.0 }, { "disease_id": "DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.", "url": "https://disease-ontology.org/term/DOID:10652", "evidence": [ { "id": "10652", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ], "weight": 0.0 }, { "disease_id": "DOID:1070", "name": "primary open angle glaucoma", "description": "An open-angle glaucoma that is characterized by the absence of any apparent obstruction of aqueous outflow through the trabecular meshwork with gonioscopy, but often with elevated intraocular pressure.", "url": "https://disease-ontology.org/term/DOID:1070", "evidence": [ { "id": "1070", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1070" } ], "weight": 0.0 }, { "disease_id": "DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries.", "url": "https://disease-ontology.org/term/DOID:10763", "evidence": [ { "id": "10763", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ], "weight": 0.0 }, { "disease_id": "DOID:10873", "name": "Kuhnt-Junius degeneration", "description": "", "url": "https://disease-ontology.org/term/DOID:10873", "evidence": [ { "id": "10873", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10873" } ], "weight": 0.0 }, { "disease_id": "DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder.", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ], "weight": 0.0 }, { "disease_id": "DOID:11394", "name": "adult respiratory distress syndrome", "description": "A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.", "url": "https://disease-ontology.org/term/DOID:11394", "evidence": [ { "id": "11394", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11394" } ], "weight": 0.0 }, { "disease_id": "DOID:11476", "name": "osteoporosis", "description": "A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength.", "url": "https://disease-ontology.org/term/DOID:11476", "evidence": [ { "id": "11476", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11476" } ], "weight": 0.0 }, { "disease_id": "DOID:11713", "name": "diabetic angiopathy", "description": "A peripheral vascular disease that is characterized by narrowing of the arteries as a complication arising from chronic diabetes.", "url": "https://disease-ontology.org/term/DOID:11713", "evidence": [ { "id": "11713", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11713" } ], "weight": 0.0 }, { "disease_id": "DOID:1184", "name": "nephrotic syndrome", "description": "A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability.", "url": "https://disease-ontology.org/term/DOID:1184", "evidence": [ { "id": "1184", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1184" } ], "weight": 0.0 }, { "disease_id": "DOID:1210", "name": "optic neuritis", "description": "An optic nerve disease that results_in inflammation located_in optic nerve which may cause a complete or partial loss of vision.", "url": "https://disease-ontology.org/term/DOID:1210", "evidence": [ { "id": "1210", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1210" } ], "weight": 0.0 }, { "disease_id": "DOID:12236", "name": "primary biliary cholangitis", "description": "A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts.", "url": "https://disease-ontology.org/term/DOID:12236", "evidence": [ { "id": "12236", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12236" } ], "weight": 0.0 }, { "disease_id": "DOID:12306", "name": "vitiligo", "description": "An autoimmune disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes.", "url": "https://disease-ontology.org/term/DOID:12306", "evidence": [ { "id": "12306", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12306" } ], "weight": 0.0 }, { "disease_id": "DOID:12930", "name": "dilated cardiomyopathy", "description": "An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently.", "url": "https://disease-ontology.org/term/DOID:12930", "evidence": [ { "id": "12930", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12930" } ], "weight": 0.0 }, { "disease_id": "DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung.", "url": "https://disease-ontology.org/term/DOID:1324", "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ], "weight": 0.0 }, { "disease_id": "DOID:13641", "name": "exfoliation syndrome", "description": "A phacogenic glaucoma that is characterized by open-angle glaucoma related to deposition of extracellular fibrillar material in anterior segment structures, which blocks aqueous fluid outflow, raises intraocular pressure, and leads to eventual optic nerve atrophy and visual field loss. Exfoliation syndrome has_symptom progressive decreased vision, especially peripheral vision. Exfoliation syndrome is caused by age-related deposition of fibrillar material in anterior segment structures.", "url": "https://disease-ontology.org/term/DOID:13641", "evidence": [ { "id": "13641", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13641" } ], "weight": 0.0 }, { "disease_id": "DOID:1389", "name": "polyneuropathy", "description": "A peripheral system disease that is characterized by damage affecting peripheral nerves (peripheral neuropathy) in roughly the same areas on both sides of the body, featuring weakness, numbness, pins-and-needles, and burning pain.", "url": "https://disease-ontology.org/term/DOID:1389", "evidence": [ { "id": "1389", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1389" } ], "weight": 0.0 }, { "disease_id": "DOID:13948", "name": "bladder neck obstruction", "description": "", "url": "https://disease-ontology.org/term/DOID:13948", "evidence": [ { "id": "13948", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13948" } ], "weight": 0.0 }, { "disease_id": "DOID:14018", "name": "alcoholic liver cirrhosis", "description": "", "url": "https://disease-ontology.org/term/DOID:14018", "evidence": [ { "id": "14018", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14018" } ], "weight": 0.0 }, { "disease_id": "DOID:14330", "name": "Parkinson's disease", "description": "A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.", "url": "https://disease-ontology.org/term/DOID:14330", "evidence": [ { "id": "14330", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14330" } ], "weight": 0.0 }, { "disease_id": "DOID:14503", "name": "neuronal ceroid lipofuscinosis", "description": "", "url": "https://disease-ontology.org/term/DOID:14503", "evidence": [ { "id": "14503", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14503" } ], "weight": 0.0 }, { "disease_id": "DOID:1459", "name": "hypothyroidism", "description": "A thyroid gland disease which involves an underproduction of thyroid hormone.", "url": "https://disease-ontology.org/term/DOID:1459", "evidence": [ { "id": "1459", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1459" } ], "weight": 0.0 }, { "disease_id": "DOID:1555", "name": "urticaria", "description": "A skin disease characterized by skin rash notable for pale red, raised and itchy bumps, located_in the upper dermis.", "url": "https://disease-ontology.org/term/DOID:1555", "evidence": [ { "id": "1555", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1555" } ], "weight": 0.0 }, { "disease_id": "DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland.", "url": "https://disease-ontology.org/term/DOID:1612", "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ], "weight": 0.0 }, { "disease_id": "DOID:162", "name": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.", "url": "https://disease-ontology.org/term/DOID:162", "evidence": [ { "id": "162", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:162" } ], "weight": 0.0 }, { "disease_id": "DOID:1679", "name": "cystitis", "description": "A bladder disease that is characterized by inflammation of the bladder.", "url": "https://disease-ontology.org/term/DOID:1679", "evidence": [ { "id": "1679", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1679" } ], "weight": 0.0 }, { "disease_id": "DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas.", "url": "https://disease-ontology.org/term/DOID:1793", "evidence": [ { "id": "1793", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ], "weight": 0.0 }, { "disease_id": "DOID:1824", "name": "status epilepticus", "description": "", "url": "https://disease-ontology.org/term/DOID:1824", "evidence": [ { "id": "1824", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1824" } ], "weight": 0.0 }, { "disease_id": "DOID:1909", "name": "melanoma", "description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye.", "url": "https://disease-ontology.org/term/DOID:1909", "evidence": [ { "id": "1909", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1909" } ], "weight": 0.0 }, { "disease_id": "DOID:224", "name": "transient cerebral ischemia", "description": "A brain ischemia that is characterized by ischemia of brief duration and without resultant tissue death.", "url": "https://disease-ontology.org/term/DOID:224", "evidence": [ { "id": "224", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:224" } ], "weight": 0.0 }, { "disease_id": "DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary.", "url": "https://disease-ontology.org/term/DOID:2394", "evidence": [ { "id": "2394", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2394" } ], "weight": 0.0 }, { "disease_id": "DOID:2738", "name": "pseudoxanthoma elasticum", "description": "A connective tissue disease that is characterized by the accumulation of deposits of calcium and other minerals in elastic fibers, which are a component of connective tissue, this can result in changes in the skin, eyes, cardiovascular system and gastrointestinal system.", "url": "https://disease-ontology.org/term/DOID:2738", "evidence": [ { "id": "2738", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2738" } ], "weight": 0.0 }, { "disease_id": "DOID:2741", "name": "bilirubin metabolic disorder", "description": "An inherited metabolic disorder that involves elevated levels of bilirubin resulting from disruption of bilirubin metabolism.", "url": "https://disease-ontology.org/term/DOID:2741", "evidence": [ { "id": "2741", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2741" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:3407", "name": "carotid artery disease", "description": "", "url": "https://disease-ontology.org/term/DOID:3407", "evidence": [ { "id": "3407", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3407" } ], "weight": 0.0 }, { "disease_id": "DOID:3429", "name": "inclusion body myositis", "description": "A myositis that is characterized by late onset of skeletal muscle inflammation, weakness, and atrophy with cytoplasmic granules and vacuoles in the muscle.", "url": "https://disease-ontology.org/term/DOID:3429", "evidence": [ { "id": "3429", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3429" } ], "weight": 0.0 }, { "disease_id": "DOID:3613", "name": "Canavan disease", "description": "A leukodystrophy characterized by onset in early infancy, atonia of neck muscles, hypotonia, hyperextension of legs and flexion of arms, blindness, severe mental defect, megalocephaly, and death by 18 months on the average that has_material_basis_in homozygous or compound heterozygous mutation in ASPA gene encoding aspartoacylase on chromosome 17p13.", "url": "https://disease-ontology.org/term/DOID:3613", "evidence": [ { "id": "3613", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3613" } ], "weight": 0.0 }, { "disease_id": "DOID:3652", "name": "Leigh disease", "description": "A cytochrome-c oxidase deficiency disease characterized by progressive loss of mental and movement abilities. Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity.", "url": "https://disease-ontology.org/term/DOID:3652", "evidence": [ { "id": "3652", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3652" } ], "weight": 0.0 }, { "disease_id": "DOID:3827", "name": "congenital diaphragmatic hernia", "description": "A diaphragm disease characterized by the lack of development of all or part of the diaphragm, which results in an abnormal opening that allows the stomach and intestines to move into the chest cavity and crowd the heart and lungs.", "url": "https://disease-ontology.org/term/DOID:3827", "evidence": [ { "id": "3827", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3827" } ], "weight": 0.0 }, { "disease_id": "DOID:4724", "name": "brain edema", "description": "A brain disease that is characterized by excess accumulation of fluid in the intracellular and/or extracellular spaces of the brain, has_symptom nausea, has_symptom vomiting, has_symptom blurred vision, has_symptom seizure, has_symptom coma.", "url": "https://disease-ontology.org/term/DOID:4724", "evidence": [ { "id": "4724", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4724" } ], "weight": 0.0 }, { "disease_id": "DOID:4914", "name": "esophagus adenocarcinoma", "description": "An esophageal carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:4914", "evidence": [ { "id": "4914", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4914" } ], "weight": 0.0 }, { "disease_id": "DOID:5082", "name": "liver cirrhosis", "description": "", "url": "https://disease-ontology.org/term/DOID:5082", "evidence": [ { "id": "5082", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5082" } ], "weight": 0.0 }, { "disease_id": "DOID:5295", "name": "intestinal disease", "description": "A gastrointestinal system disease that is located_in the intestine.", "url": "https://disease-ontology.org/term/DOID:5295", "evidence": [ { "id": "5295", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5295" } ], "weight": 0.0 }, { "disease_id": "DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.", "url": "https://disease-ontology.org/term/DOID:5844", "evidence": [ { "id": "5844", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ], "weight": 0.0 }, { "disease_id": "DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.", "url": "https://disease-ontology.org/term/DOID:6000", "evidence": [ { "id": "6000", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ], "weight": 0.0 }, { "disease_id": "DOID:6196", "name": "reactive arthritis", "description": "An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body.", "url": "https://disease-ontology.org/term/DOID:6196", "evidence": [ { "id": "6196", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6196" } ], "weight": 0.0 }, { "disease_id": "DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.", "url": "https://disease-ontology.org/term/DOID:684", "evidence": [ { "id": "684", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:684" } ], "weight": 0.0 }, { "disease_id": "DOID:705", "name": "Leber hereditary optic neuropathy", "description": "", "url": "https://disease-ontology.org/term/DOID:705", "evidence": [ { "id": "705", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:705" } ], "weight": 0.0 }, { "disease_id": "DOID:7693", "name": "abdominal aortic aneurysm", "description": "An aortic aneurysm that is located_in the abdominal aorta.", "url": "https://disease-ontology.org/term/DOID:7693", "evidence": [ { "id": "7693", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:7693" } ], "weight": 0.0 }, { "disease_id": "DOID:8568", "name": "infectious mononucleosis", "description": "A viral infectious disease that results in inflammation, located in pharynx, has_material_basis_in Human herpesvirus 4 (Lymphocryptovirus humangamma4) and has symptom fever, has symptom fatigue, has symptom lymphadenopathy, and has symptom splenomegaly.", "url": "https://disease-ontology.org/term/DOID:8568", "evidence": [ { "id": "8568", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8568" } ], "weight": 0.0 }, { "disease_id": "DOID:8691", "name": "mycosis fungoides", "description": "", "url": "https://disease-ontology.org/term/DOID:8691", "evidence": [ { "id": "8691", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8691" } ], "weight": 0.0 }, { "disease_id": "DOID:8893", "name": "psoriasis", "description": "A skin disease that is characterized by patches of thick red skin and silvery scales.", "url": "https://disease-ontology.org/term/DOID:8893", "evidence": [ { "id": "8893", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8893" } ], "weight": 0.0 }, { "disease_id": "DOID:9074", "name": "systemic lupus erythematosus", "description": "A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.", "url": "https://disease-ontology.org/term/DOID:9074", "evidence": [ { "id": "9074", "database": "AGR", "url": 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airway obstruction after the ingestion of aspirin or other non-steroidal anti-inflammatory drugs.", "url": "https://disease-ontology.org/term/DOID:0080822", "evidence": [ { "id": "0080822", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080822" } ], "weight": 0.0 }, { "disease_id": "DOID:0080855", "name": "Parkinsonism", "description": "A movement disorder that is characterized by disturbances of balance, gait and posture.", "url": "https://disease-ontology.org/term/DOID:0080855", "evidence": [ { "id": "0080855", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080855" } ], "weight": 0.0 }, { "disease_id": "DOID:0081267", "name": "graft-versus-host disease", "description": "An immune system disease that is characterized by recognition by mature donor T cells, that contaminate the allogeneic bone marrow, of the recipient's tissue as foreign, causing a severe inflammatory disease characterized by rashes, diarrhea, and liver disease, and 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decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.", "url": "https://disease-ontology.org/term/DOID:10652", "evidence": [ { "id": "10652", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ], "weight": 0.0 }, { "disease_id": "DOID:1073", "name": "renal hypertension", "description": "", "url": "https://disease-ontology.org/term/DOID:1073", "evidence": [ { "id": "1073", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1073" } ], "weight": 0.0 }, { "disease_id": "DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries.", "url": "https://disease-ontology.org/term/DOID:10763", "evidence": [ { "id": "10763", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ], "weight": 0.0 }, { "disease_id": "DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder.", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ], "weight": 0.0 }, { "disease_id": "DOID:1229", "name": "paranoid schizophrenia", "description": "A schizophrenia characterized by delusions or auditory hallucinations of persecution or being plotted against without thought disorder, disorganized behavior, or affective flattening.", "url": "https://disease-ontology.org/term/DOID:1229", "evidence": [ { "id": "1229", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1229" } ], "weight": 0.0 }, { "disease_id": "DOID:12306", "name": "vitiligo", "description": "An autoimmune disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes.", "url": "https://disease-ontology.org/term/DOID:12306", "evidence": [ { "id": "12306", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12306" } ], "weight": 0.0 }, { "disease_id": "DOID:1287", "name": "cardiovascular system disease", "description": "A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.", "url": "https://disease-ontology.org/term/DOID:1287", "evidence": [ { "id": "1287", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1287" } ], "weight": 0.0 }, { "disease_id": "DOID:13141", "name": "uveitis", "description": "An uveal disease is characterized by inflammation of any of the layers of the uvea of the eye, which includes the iris, ciliary body, and choroid.", "url": "https://disease-ontology.org/term/DOID:13141", "evidence": [ { "id": "13141", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13141" } ], "weight": 0.0 }, { "disease_id": "DOID:13378", "name": "Kawasaki disease", "description": "A lymphadenitis characterized by swelling of cervical lymph nodes in infants and young children and inflammation of medium-sized blood vessels and that symptoms of fever, congestion of ocular conjunctivae, reddening of lips, reddening of oral cavity, protuberance of tongue papillae and edema of extremities.", "url": "https://disease-ontology.org/term/DOID:13378", "evidence": [ { "id": "13378", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13378" } ], "weight": 0.0 }, { "disease_id": "DOID:14115", "name": "toxic shock syndrome", "description": "A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus, which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities.", "url": "https://disease-ontology.org/term/DOID:14115", "evidence": [ { "id": "14115", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14115" } ], "weight": 0.0 }, { "disease_id": "DOID:14330", "name": "Parkinson's disease", "description": "A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.", "url": "https://disease-ontology.org/term/DOID:14330", "evidence": [ { "id": "14330", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14330" } ], "weight": 0.0 }, { "disease_id": "DOID:1470", "name": "major depressive disorder", "description": "A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality.", "url": "https://disease-ontology.org/term/DOID:1470", "evidence": [ { "id": "1470", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1470" } ], "weight": 0.0 }, { "disease_id": "DOID:1485", "name": "cystic fibrosis", "description": "A syndrome that is characterized by the buildup of thick, sticky mucus that can damage many organs.", "url": "https://disease-ontology.org/term/DOID:1485", "evidence": [ { "id": "1485", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1485" } ], "weight": 0.0 }, { "disease_id": "DOID:1824", "name": "status epilepticus", "description": "", "url": "https://disease-ontology.org/term/DOID:1824", "evidence": [ { "id": "1824", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1824" } ], "weight": 0.0 }, { "disease_id": "DOID:1936", "name": "atherosclerosis", "description": "An arteriosclerotic cardiovascular disease that is characterized by the build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen. 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any type of epithelial lung cancer other than small cell lung carcinoma.", "url": "https://disease-ontology.org/term/DOID:3908", "evidence": [ { "id": "3908", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ], "weight": 0.0 }, { "disease_id": "DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix.", "url": "https://disease-ontology.org/term/DOID:4362", "evidence": [ { "id": "4362", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4362" } ], "weight": 0.0 }, { "disease_id": "DOID:4448", "name": "macular degeneration", "description": "A retinal degeneration characterized by gradual deterioration of light-sensing cells in the tissues at the back of the eye and has_symptom vision loss.", "url": "https://disease-ontology.org/term/DOID:4448", "evidence": [ { "id": "4448", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4448" } ], "weight": 0.0 }, { 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Loss of elongator complex activity, reduced levels of mcm5U and ncm5U on tRNA and reduced interaction with HRR25 but no effect on elongator complex assembly; when associated with A-1202.", "evidence": [ { "database": "UniProtKB", "id": "Q06706", "url": "https://www.uniprot.org/uniprotkb/Q06706" }, { "database": "PubMed", "id": "25569479", "url": "https://glygen.org/publication/PubMed/25569479" } ] }, { "sequence_org": "S", "sequence_mut": "E", "comment": "Slightly reduced levels of mcm5U and ncm5U on tRNA; when associated with E-1202.", "evidence": [ { "database": "UniProtKB", "id": "Q06706", "url": "https://www.uniprot.org/uniprotkb/Q06706" }, { "database": "PubMed", "id": "25569479", "url": "https://glygen.org/publication/PubMed/25569479" } ] } ] }, { "uniprot_canonical_ac": "Q06706-1", "start_pos": "1202", "end_pos": "1202", "site_lbl": "Ser1202", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "UniProtKB", "id": "Q06706", "url": "https://www.uniprot.org/uniprotkb/Q06706" }, { "database": "iPTMnet", "id": "Q06706", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06706" }, { "database": "PubMed", "id": "25569479", "url": "https://glygen.org/publication/PubMed/25569479" }, { "database": "SGD", "id": "S000004376", "url": "https://www.yeastgenome.org/locus/S000004376" }, { "database": "PubMed", "id": "32597660", "url": "https://glygen.org/publication/PubMed/32597660" }, { "database": "PubMed", "id": "33491328", "url": "https://glygen.org/publication/PubMed/33491328" } ] } ], "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Does not affect elongator complex activity. 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Loss of elongator complex activity. Almost complete loss of mcm5U and ncm5U on tRNA. Does not affect elongator complex assembly. Enhances interaction with HRR25 and KTI12.", "evidence": [ { "database": "UniProtKB", "id": "Q06706", "url": "https://www.uniprot.org/uniprotkb/Q06706" }, { "database": "PubMed", "id": "25569479", "url": "https://glygen.org/publication/PubMed/25569479" } ] }, { "sequence_org": "S", "sequence_mut": "D", "comment": "Phosphomimetic mutant. Does not affect elongator complex activity.", "evidence": [ { "database": "UniProtKB", "id": "Q06706", "url": "https://www.uniprot.org/uniprotkb/Q06706" }, { "database": "PubMed", "id": "25569479", "url": "https://glygen.org/publication/PubMed/25569479" } ] } ] }, { "uniprot_canonical_ac": "Q06706-1", "start_pos": "1215", "end_pos": "1215", "site_lbl": "Thr1215", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "SGD", "id": "S000004376", "url": "https://www.yeastgenome.org/locus/S000004376" }, { "database": "iPTMnet", "id": "Q06706", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06706" }, { "database": "PubMed", "id": "33491328", "url": "https://glygen.org/publication/PubMed/33491328" } ] } ] }, { "uniprot_canonical_ac": "Q06706-1", "start_pos": "1218", "end_pos": "1218", "site_lbl": "Thr1218", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "SGD", "id": "S000004376", "url": "https://www.yeastgenome.org/locus/S000004376" }, { "database": "iPTMnet", "id": "Q06706", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06706" }, { "database": "PubMed", "id": "33491328", "url": "https://glygen.org/publication/PubMed/33491328" } ] } ] }, { "uniprot_canonical_ac": "Q06706-1", "start_pos": "1221", "end_pos": "1221", "site_lbl": "Thr1221", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "SGD", "id": "S000004376", "url": "https://www.yeastgenome.org/locus/S000004376" }, { "database": "iPTMnet", "id": "Q06706", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06706" }, { "database": "PubMed", "id": "33491328", "url": "https://glygen.org/publication/PubMed/33491328" } ] } ] }, { "uniprot_canonical_ac": "Q06706-1", "start_pos": "218", "end_pos": "218", "site_lbl": "Ser218", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "SGD", "id": "S000004376", "url": "https://www.yeastgenome.org/locus/S000004376" }, { "database": "iPTMnet", "id": "Q06706", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06706" }, { "database": "PubMed", "id": "33481703", "url": "https://glygen.org/publication/PubMed/33481703" }, { "database": "PubMed", "id": "33491328", "url": "https://glygen.org/publication/PubMed/33491328" } ] } ] }, { "uniprot_canonical_ac": "Q06706-1", "start_pos": "279", "end_pos": "279", "site_lbl": "Ser279", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "SGD", "id": "S000004376", "url": "https://www.yeastgenome.org/locus/S000004376" }, { "database": "iPTMnet", "id": "Q06706", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06706" }, { "database": "PubMed", "id": "33491328", "url": "https://glygen.org/publication/PubMed/33491328" } ] } ] }, { "uniprot_canonical_ac": "Q06706-1", "start_pos": "521", "end_pos": "521", "site_lbl": "Ser521", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "SGD", "id": "S000004376", "url": "https://www.yeastgenome.org/locus/S000004376" }, { "database": "iPTMnet", "id": "Q06706", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06706" }, { "database": "PubMed", "id": "33481703", "url": "https://glygen.org/publication/PubMed/33481703" } ] } ] }, { "uniprot_canonical_ac": "Q06706-1", "start_pos": "529", "end_pos": "529", "site_lbl": "Ser529", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "UniProtKB", "id": "Q06706", "url": "https://www.uniprot.org/uniprotkb/Q06706" }, { "database": "PubMed", "id": "25569479", "url": "https://glygen.org/publication/PubMed/25569479" }, { "database": "SGD", "id": "S000004376", "url": "https://www.yeastgenome.org/locus/S000004376" }, { "database": "iPTMnet", "id": "Q06706", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06706" }, { "database": "PubMed", "id": "33481703", "url": "https://glygen.org/publication/PubMed/33481703" }, { "database": "PubMed", "id": "33491328", "url": "https://glygen.org/publication/PubMed/33491328" } ] } ], "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Does not affect elongator complex activity.", "evidence": [ { "database": "UniProtKB", "id": "Q06706", "url": "https://www.uniprot.org/uniprotkb/Q06706" }, { "database": "PubMed", "id": "25569479", "url": "https://glygen.org/publication/PubMed/25569479" } ] } ] }, { "uniprot_canonical_ac": "Q06706-1", "start_pos": "539", "end_pos": "539", "site_lbl": "Ser539", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "UniProtKB", "id": "Q06706", "url": "https://www.uniprot.org/uniprotkb/Q06706" }, { "database": "PubMed", "id": "25569479", "url": "https://glygen.org/publication/PubMed/25569479" }, { "database": "iPTMnet", "id": "Q06706", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06706" } ] } ], "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Does not affect elongator complex activity.", "evidence": [ { "database": "UniProtKB", "id": "Q06706", "url": "https://www.uniprot.org/uniprotkb/Q06706" }, { "database": "PubMed", "id": "25569479", "url": "https://glygen.org/publication/PubMed/25569479" } ] } ] }, { "uniprot_canonical_ac": "Q06706-1", "start_pos": "551", "end_pos": "551", "site_lbl": "Ser551", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "UniProtKB", "id": "Q06706", "url": "https://www.uniprot.org/uniprotkb/Q06706" }, { "database": "PubMed", "id": "25569479", "url": "https://glygen.org/publication/PubMed/25569479" }, { "database": "iPTMnet", "id": "Q06706", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06706" } ] } ], "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Does not affect elongator complex activity.", "evidence": [ { "database": "UniProtKB", "id": "Q06706", "url": "https://www.uniprot.org/uniprotkb/Q06706" }, { "database": "PubMed", "id": "25569479", "url": "https://glygen.org/publication/PubMed/25569479" } ] } ] }, { "uniprot_canonical_ac": "Q06706-1", "start_pos": "636", "end_pos": "636", "site_lbl": "Ser636", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "UniProtKB", "id": "Q06706", "url": "https://www.uniprot.org/uniprotkb/Q06706" }, { "database": "PubMed", "id": "25569479", "url": "https://glygen.org/publication/PubMed/25569479" }, { "database": "SGD", "id": "S000004376", "url": "https://www.yeastgenome.org/locus/S000004376" }, { "database": "iPTMnet", "id": "Q06706", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q06706" }, { "database": "PubMed", "id": "33491328", "url": "https://glygen.org/publication/PubMed/33491328" } ] } ], "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Does not affect elongator complex activity.", "evidence": [ { "database": "UniProtKB", "id": "Q06706", "url": "https://www.uniprot.org/uniprotkb/Q06706" }, { "database": "PubMed", "id": "25569479", "url": "https://glygen.org/publication/PubMed/25569479" } ] } ] }, { "uniprot_canonical_ac": "Q06706-1", "start_pos": "828", "end_pos": "828", "site_lbl": "Ser828", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "UniProtKB", "id": "Q06706", "url": "https://www.uniprot.org/uniprotkb/Q06706" }, { "database": "PubMed", "id": "25569479", "url": 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associated with A-1282 and A-1286.", "evidence": [ { "database": "UniProtKB", "id": "Q06706", "url": "https://www.uniprot.org/uniprotkb/Q06706" }, { "database": "PubMed", "id": "26261306", "url": "https://glygen.org/publication/PubMed/26261306" } ] } ] }, { "uniprot_canonical_ac": "Q06706-1", "start_pos": "1282", "end_pos": "1282", "site_lbl": "Arg1282", "weight": 0.0, "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "A", "comment": "Disrupts dimer formation and elongator complex formation but does not affect binding to tRNA; when associated with A-1063 and A-1286.", "evidence": [ { "database": "UniProtKB", "id": "Q06706", "url": "https://www.uniprot.org/uniprotkb/Q06706" }, { "database": "PubMed", "id": "26261306", "url": "https://glygen.org/publication/PubMed/26261306" } ] } ] }, { "uniprot_canonical_ac": "Q06706-1", "start_pos": "1286", "end_pos": "1286", "site_lbl": "Arg1286", "weight": 0.0, "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "A", "comment": "Disrupts dimer formation and elongator complex formation but does not affect binding to tRNA; when associated with A-1063 and A-1282.", "evidence": [ { "database": "UniProtKB", "id": "Q06706", "url": "https://www.uniprot.org/uniprotkb/Q06706" }, { "database": "PubMed", "id": "26261306", "url": "https://glygen.org/publication/PubMed/26261306" } ] } ] } ], "record_id": "Q06706-1" }, { "uniprot_canonical_ac": "Q06833-1", "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "Q06833", "url": "https://www.uniprot.org/uniprotkb/Q06833" } ], "common_name": "Baker's yeast", "glygen_name": "Yeast", "reference_species": "Saccharomyces cerevisiae S288C [559292]" } ], "length": 770, "chemical_mass": 87324.0, "gene_names": "NVJ2;NVJ2", "protein_name": "Nucleus-vacuole junction protein 2", "disease": [], "cellular_component": [ { "name": "nucleus-vacuole junction", "id": "GO:0071561", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071561", 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"evidence": [ { "database": "UniProtKB", "id": "Q06833", "url": "https://www.uniprot.org/uniprotkb/Q06833" } ], "pmid": "" }, { "name": "cell periphery", "id": "GO:0071944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071944", "evidence": [ { "database": "UniProtKB", "id": "Q06833", "url": "https://www.uniprot.org/uniprotkb/Q06833" } ], "pmid": "" } ], "molecular_function": [ { "name": "lipid transporter activity", "id": "GO:0005319", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005319", "evidence": [ { "database": "UniProtKB", "id": "Q06833", "url": "https://www.uniprot.org/uniprotkb/Q06833" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "Q06833", "url": "https://www.uniprot.org/uniprotkb/Q06833" } ], "pmid": "" } ], "biological_process": [ { "name": "ER to Golgi ceramide transport", "id": "GO:0035621", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035621", 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