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assists assembly of type VII collagen.", "url": "https://disease-ontology.org/term/DOID:0080224", "evidence": [ { "id": "0080224", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080224" } ], "weight": 0.0 }, { "disease_id": "DOID:0080988", "name": "pretibial dystrophic epidermolysis bullosa", "description": "An epidermolysis bullosa dystrophica that is characterized by recurrent blistering and scarring, mainly in the pretibial area and that has_material_basis_in heterozygous or compound heterozygous mutation in the type VII collagen gene (COL7A1) on chromosome 3p21. The lesions often show lichenoid features. Pretibial epidermolysis bullosa is allelic to autosomal dominant and recessive dystrophic epidermolysis bullosa.", "url": "https://disease-ontology.org/term/DOID:0080988", "evidence": [ { "id": "0080988", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080988" } ], "weight": 0.0 }, { "disease_id": "DOID:0111345", "name": "transient bullous dermolysis of the newborn", "description": "An epidermolysis bullosa dystrophica characterized by generalized blistering at birth that usually regresses by 6 to 24 months of age that has_material_basis_in heterozygous, compound heterozygous or homozygous mutation in COL7A1 on chromosome 3p21.31.", "url": "https://disease-ontology.org/term/DOID:0111345", "evidence": [ { "id": "0111345", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111345" } ], "weight": 0.0 }, { "disease_id": "DOID:0111347", "name": "epidermolysis bullosa with congenital localized absence of skin and deformity of nails", "description": "An autosomal dominant dystrophic epidermolysis bullosa characterized by severe blistering of skin and mucous membranes, congenital absence of skin on the lower extremities and congenital absence or deformity of nails that has_material_basis_in heterozygous mutation in the COL7A1 gene on chromosome 3p21.31.", "url": "https://disease-ontology.org/term/DOID:0111347", "evidence": [ { "id": "0111347", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111347" } ], "weight": 0.0 }, { "disease_id": "DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries.", "url": "https://disease-ontology.org/term/DOID:10763", "evidence": [ { "id": "10763", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ], "weight": 0.0 }, { "disease_id": "DOID:1936", "name": "atherosclerosis", "description": "An arteriosclerotic cardiovascular disease that is characterized by the build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen. Disease is located within the tunica intima of large and small arteries.", "url": "https://disease-ontology.org/term/DOID:1936", "evidence": [ { "id": "1936", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1936" } ], "weight": 0.0 }, { "disease_id": "DOID:4959", "name": "epidermolysis bullosa dystrophica", "description": "An epidermolysis bullosa that is characterized by formation of recurrent blisters secondary to minor trauma in the skin and mucosa, especially in the hands, feet, knees, and elbows, and has_material_basis_in mutation in COL7A1 gene, which encodes a protein that assists assembly of type VII collagen.", "url": "https://disease-ontology.org/term/DOID:4959", "evidence": [ { "id": "4959", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4959" } ], "weight": 0.0 }, { "disease_id": "DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.", "url": "https://disease-ontology.org/term/DOID:6000", "evidence": [ { "id": "6000", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ], "weight": 0.0 } ], "biological_process": [ { "name": "negative regulation of follicle-stimulating hormone secretion", "id": "GO:0046882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046882", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "cellular response to hypoxia", "id": "GO:0071456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071456", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "hormone-mediated signaling pathway", "id": "GO:0009755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009755", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "digestion", "id": "GO:0007586", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007586", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "cellular response to nutrient levels", "id": "GO:0031669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031669", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "tissue regeneration", "id": "GO:0042246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042246", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "cellular response to glucocorticoid stimulus", "id": "GO:0071385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071385", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "response to immobilization stress", "id": "GO:0035902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035902", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "negative regulation of luteinizing hormone secretion", "id": "GO:0033685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033685", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "extracellular matrix organization", "id": "GO:0030198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "collagen fibril organization", "id": "GO:0030199", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030199", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "endodermal cell differentiation", "id": "GO:0035987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035987", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" } ], "molecular_function": [ { "name": "corticotropin-releasing hormone receptor binding", "id": "GO:0051429", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051429", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "G protein-coupled receptor binding", "id": "GO:0001664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001664", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "hormone binding", "id": "GO:0042562", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042562", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "corticotropin-releasing hormone receptor 2 binding", "id": "GO:0051431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051431", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "extracellular matrix structural constituent conferring tensile strength", "id": "GO:0030020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030020", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" } ], "cellular_component": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" }, { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "Q91WW1", "url": "https://www.uniprot.org/uniprotkb/Q91WW1" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "Q91WW1-1" }, { "uniprot_canonical_ac": "Q91ZW1-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q91ZW1", "url": "https://www.uniprot.org/uniprotkb/Q91ZW1" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 244, "chemical_mass": 28187.0, "gene_names": "Tfam;Mttfa;Tfam", "protein_name": "Transcription factor A, mitochondrial", "disease": [ { "disease_id": "DOID:0080337", "name": "mitochondrial DNA depletion syndrome 15", "description": "A mitochondrial DNA depletion syndrome that is characterized by severe intrauterine growth restriction, neonatal-onset hypoglycemia and liver dysfunction, mitochondrial DNA depletion in liver and skeletal muscle, and abnormal mitochondrial morphology observed in skeletal muscle and has_material_basis_in homozygous mutation in the TFAM gene on chromosome 10q21.", "url": "https://disease-ontology.org/term/DOID:0080337", "evidence": [ { "id": "0080337", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080337" } ], "weight": 0.0 }, { "disease_id": "DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.", "url": "https://disease-ontology.org/term/DOID:10652", "evidence": [ { "id": "10652", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ], "weight": 0.0 }, { "disease_id": "DOID:12858", "name": "Huntington's disease", "description": "A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities.", "url": "https://disease-ontology.org/term/DOID:12858", "evidence": [ { "id": "12858", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12858" } ], "weight": 0.0 }, { "disease_id": "DOID:12934", "name": "Kearns-Sayre syndrome", "description": "A chronic progressive external ophthalmoplegia characterized by progressive external ophthalmoplegia, pigmentary retinopathy, and one or more of heart block, cerebellar ataxia, or a cerebrospinal fluid protein level above 100 mg/dl, that has_material_basis_in deletion of mitochondrial DNA. Onset is before 20 years of age.", "url": "https://disease-ontology.org/term/DOID:12934", "evidence": [ { "id": "12934", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12934" } ], "weight": 0.0 }, { "disease_id": "DOID:14330", "name": "Parkinson's disease", "description": "A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.", "url": "https://disease-ontology.org/term/DOID:14330", "evidence": [ { "id": "14330", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14330" } ], "weight": 0.0 }, { "disease_id": "DOID:1824", "name": "status epilepticus", "description": "", "url": "https://disease-ontology.org/term/DOID:1824", "evidence": [ { "id": "1824", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1824" } ], "weight": 0.0 }, { "disease_id": "DOID:332", "name": "amyotrophic lateral sclerosis", "description": "A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.", "url": "https://disease-ontology.org/term/DOID:332", "evidence": [ { "id": "332", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:332" } ], "weight": 0.0 }, { "disease_id": "DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.", "url": "https://disease-ontology.org/term/DOID:9970", "evidence": [ { "id": "9970", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9970" } ], "weight": 0.0 } ], "biological_process": [ { "name": "mitochondrial respiratory chain complex assembly", "id": "GO:0033108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033108", "evidence": [ { "database": "UniProtKB", "id": "Q91ZW1", "url": "https://www.uniprot.org/uniprotkb/Q91ZW1" } ], "pmid": "" }, { "name": "transcription initiation at mitochondrial promoter", "id": "GO:0006391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006391", "evidence": [ { "database": "UniProtKB", "id": "Q91ZW1", "url": "https://www.uniprot.org/uniprotkb/Q91ZW1" } ], "pmid": "" }, { "name": "response to nutrient", "id": "GO:0007584", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007584", "evidence": [ { "database": "UniProtKB", "id": "Q91ZW1", "url": "https://www.uniprot.org/uniprotkb/Q91ZW1" } ], "pmid": "" }, { "name": "response to hypoxia", "id": "GO:0001666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001666", "evidence": [ { "database": "UniProtKB", "id": "Q91ZW1", "url": 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"Q91ZW1", "url": "https://www.uniprot.org/uniprotkb/Q91ZW1" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "Q91ZW1", "url": "https://www.uniprot.org/uniprotkb/Q91ZW1" } ], "pmid": "" }, { "name": "transcription coactivator binding", "id": "GO:0001223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001223", "evidence": [ { "database": "UniProtKB", "id": "Q91ZW1", "url": "https://www.uniprot.org/uniprotkb/Q91ZW1" } ], "pmid": "" }, { "name": "mitochondrial transcription factor activity", "id": "GO:0034246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034246", "evidence": [ { "database": "UniProtKB", "id": "Q91ZW1", "url": "https://www.uniprot.org/uniprotkb/Q91ZW1" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", 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"GO:0010039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010039", "evidence": [ { "database": "UniProtKB", "id": "Q99MH3", "url": "https://www.uniprot.org/uniprotkb/Q99MH3" } ], "pmid": "" }, { "name": "negative regulation of iron ion transmembrane transport", "id": "GO:0034760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034760", "evidence": [ { "database": "UniProtKB", "id": "Q99MH3", "url": "https://www.uniprot.org/uniprotkb/Q99MH3" } ], "pmid": "" }, { "name": "myeloid cell homeostasis", "id": "GO:0002262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002262", "evidence": [ { "database": "UniProtKB", "id": "Q99MH3", "url": "https://www.uniprot.org/uniprotkb/Q99MH3" } ], "pmid": "" }, { "name": "negative regulation of bone resorption", "id": "GO:0045779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045779", "evidence": [ { "database": "UniProtKB", "id": "Q99MH3", "url": "https://www.uniprot.org/uniprotkb/Q99MH3" } ], "pmid": "" }, { "name": "defense response to fungus", "id": "GO:0050832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050832", "evidence": [ { "database": "UniProtKB", "id": "Q99MH3", "url": "https://www.uniprot.org/uniprotkb/Q99MH3" } ], "pmid": "" }, { "name": "cellular response to X-ray", "id": "GO:0071481", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071481", "evidence": [ { "database": "UniProtKB", "id": "Q99MH3", "url": "https://www.uniprot.org/uniprotkb/Q99MH3" } ], "pmid": "" }, { "name": "multicellular organismal-level iron ion homeostasis", "id": "GO:0060586", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060586", "evidence": [ { "database": "UniProtKB", "id": "Q99MH3", "url": "https://www.uniprot.org/uniprotkb/Q99MH3" } ], "pmid": "" }, { "name": "positive regulation of protein polyubiquitination", "id": "GO:1902916", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902916", "evidence": [ { "database": "UniProtKB", "id": "Q99MH3", "url": "https://www.uniprot.org/uniprotkb/Q99MH3" } ], "pmid": "" }, { "name": "cell surface 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acid transmembrane transporter activity", "id": "GO:0015171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015171", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" } ], "pmid": "" }, { "name": "neutral L-amino acid transmembrane transporter activity", "id": "GO:0015175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015175", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" } ], "pmid": "" }, { "name": "L-glutamine transmembrane transporter activity", "id": "GO:0015186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015186", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" } ], "pmid": "" }, { "name": "L-serine transmembrane transporter activity", "id": "GO:0015194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015194", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" } ], "pmid": "" }, { "name": "amino acid:sodium symporter activity", "id": "GO:0005283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005283", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" } ], "pmid": "" }, { "name": "acidic amino acid transmembrane transporter activity", "id": "GO:0015172", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015172", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" } ], "pmid": "" }, { "name": "neutral L-amino acid:sodium symporter activity", "id": "GO:0005295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005295", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" } ], "pmid": "" }, { "name": "alanine:sodium symporter activity", "id": "GO:0015655", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015655", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" } ], "pmid": "" } ], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" } ], "pmid": "" }, { "name": "brush border", "id": "GO:0005903", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005903", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" } ], "pmid": "" }, { "name": "sarcolemma", "id": "GO:0042383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "Q9JHE5-1", "start_pos": "254", "end_pos": "254", "site_lbl": "Asn254", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 254, "start_aa": "Asn", "end_pos": 254, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn254", "evidence": [ { "id": "Q9JHE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5#ptm_processing" }, { "id": "29678469", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29678469" } ] } ], "mutagenesis": [ { "sequence_org": "N", "sequence_mut": "Q", "comment": "Partially loss of glycosylation. Completely loss of glycosylation; when associated with Q-258 and Q-272. Decreases expression; when associated with Q-258 and Q-272. Does not affect cell membrane localization; when associated with Q-258 and Q-272.", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" }, { "database": "PubMed", "id": "29678469", "url": "https://glygen.org/publication/PubMed/29678469" } ] } ] }, { "uniprot_canonical_ac": "Q9JHE5-1", "start_pos": "258", "end_pos": "258", "site_lbl": "Asn258", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 258, "start_aa": "Asn", "end_pos": 258, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn258", "evidence": [ { "id": "Q9JHE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5#ptm_processing" }, { "id": "29678469", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29678469" } ] } ], "mutagenesis": [ { "sequence_org": "N", "sequence_mut": "Q", "comment": "Partially loss of glycosylation. Dramatically loss of glycosylation; when associated with Q-272. Completely loss of glycosylation; when associated with Q-254 and Q-272. Decreases expression; when associated with Q-272. Decreases expression; when associated with Q-254 and Q-272. Does not affect cell membrane localization; when associated with Q-272. Does not affect cell membrane localization; when associated with Q-254 and Q-272.", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" }, { "database": "PubMed", "id": "29678469", "url": "https://glygen.org/publication/PubMed/29678469" } ] } ] }, { "uniprot_canonical_ac": "Q9JHE5-1", "start_pos": "272", "end_pos": "272", "site_lbl": "Asn272", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 272, "start_aa": "Asn", "end_pos": 272, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn272", "evidence": [ { "id": "Q9JHE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5#ptm_processing" }, { "id": "29678469", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29678469" } ] } ], "mutagenesis": [ { "sequence_org": "N", "sequence_mut": "Q", "comment": "Partially loss of glycosylation. Dramatically loss of glycosylation; when associated with Q-258. Completely loss of glycosylation; when associated with Q-254 and Q-258. Decreases expression; when associated with Q-258. Decreases expression; when associated with Q-254 and Q-258. Does not affect cell membrane localization; when associated with Q-258. Does not affect cell membrane localization; when associated with Q-254 and Q-258.", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" }, { "database": "PubMed", "id": "29678469", "url": "https://glygen.org/publication/PubMed/29678469" } ] } ] }, { "uniprot_canonical_ac": "Q9JHE5-1", "start_pos": "12", "end_pos": "12", "site_lbl": "Ser12", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" } ] } ] }, { "uniprot_canonical_ac": "Q9JHE5-1", "start_pos": "21", "end_pos": "21", "site_lbl": "Ser21", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" } ] } ] }, { "uniprot_canonical_ac": "Q9JHE5-1", "start_pos": "22", "end_pos": "22", "site_lbl": "Ser22", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" } ] } ] }, { "uniprot_canonical_ac": "Q9JHE5-1", "start_pos": "55", "end_pos": "55", "site_lbl": "Ser55", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" } ] } ] }, { "uniprot_canonical_ac": "Q9JHE5-1", "start_pos": "228", "end_pos": "228", "site_lbl": "Cys228", "weight": 0.0, "mutagenesis": [ { "sequence_org": "C", "sequence_mut": "S", "comment": "Reduces amino acid transport activity of 75%. Significantly decreases alanine transport activity.", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" }, { "database": "PubMed", "id": "27355203", "url": "https://glygen.org/publication/PubMed/27355203" } ] } ] }, { "uniprot_canonical_ac": "Q9JHE5-1", "start_pos": "238", "end_pos": "238", "site_lbl": "Cys238", "weight": 0.0, "mutagenesis": [ { "sequence_org": "C", "sequence_mut": "S", "comment": "Decreases alanine transport activity.", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" }, { "database": "PubMed", "id": "27355203", "url": "https://glygen.org/publication/PubMed/27355203" } ] } ] }, { "uniprot_canonical_ac": "Q9JHE5-1", "start_pos": "245", "end_pos": "245", "site_lbl": "Cys245", "weight": 0.0, "mutagenesis": [ { "sequence_org": "C", "sequence_mut": "A", "comment": "Does not affect cell membrane localization.", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" }, { "database": "PubMed", "id": "27355203", "url": "https://glygen.org/publication/PubMed/27355203" } ] }, { "sequence_org": "C", "sequence_mut": "S", "comment": "Does not affect amino acid transport activity. Significantly decreases alanine transport activity.", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" }, { "database": "PubMed", "id": "27355203", "url": "https://glygen.org/publication/PubMed/27355203" } ] } ] }, { "uniprot_canonical_ac": "Q9JHE5-1", "start_pos": "279", "end_pos": "279", "site_lbl": "Cys279", "weight": 0.0, "mutagenesis": [ { "sequence_org": "C", "sequence_mut": "A", "comment": "Does not affect cell membrane localization.", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" }, { "database": "PubMed", "id": "27355203", "url": "https://glygen.org/publication/PubMed/27355203" } ] }, { "sequence_org": "C", "sequence_mut": "S", "comment": "Does not affect amino acid transport activity. Significantly decreases alanine transport activity.", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" }, { "database": "PubMed", "id": "27355203", "url": "https://glygen.org/publication/PubMed/27355203" } ] } ] }, { "uniprot_canonical_ac": "Q9JHE5-1", "start_pos": "303", "end_pos": "303", "site_lbl": "Cys303", "weight": 0.0, "mutagenesis": [ { "sequence_org": "C", "sequence_mut": "S", "comment": "Reduces amino acid transport activity of 75%. Significantly decreases alanine transport activity.", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" }, { "database": "PubMed", "id": "27355203", "url": "https://glygen.org/publication/PubMed/27355203" } ] } ] }, { "uniprot_canonical_ac": "Q9JHE5-1", "start_pos": "337", "end_pos": "337", "site_lbl": "Tyr337", "weight": 0.0, "mutagenesis": [ { "sequence_org": "Y", "sequence_mut": "A", "comment": "Impairs transport current. Reduces the amino acid affinity.", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" }, { "database": "PubMed", "id": "18319257", "url": "https://glygen.org/publication/PubMed/18319257" } ] } ] }, { "uniprot_canonical_ac": "Q9JHE5-1", "start_pos": "374", "end_pos": "374", "site_lbl": "Arg374", "weight": 0.0, "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "Q", "comment": "Does not affect the alanine-induced transport current. Reduces the amino acid affinity.", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" }, { "database": "PubMed", "id": "18319257", "url": "https://glygen.org/publication/PubMed/18319257" } ] } ] }, { "uniprot_canonical_ac": "Q9JHE5-1", "start_pos": "384", "end_pos": "384", "site_lbl": "Thr384", "weight": 0.0, "mutagenesis": [ { "sequence_org": "T", "sequence_mut": "A", "comment": "Does not affect cell membrane localization. Eliminates the sodium-induced anion leak current. Inhibits amino acid transport activity. Reduces affinity for sodium ion.", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" }, { "database": "PubMed", "id": "19589777", "url": "https://glygen.org/publication/PubMed/19589777" } ] } ] }, { "uniprot_canonical_ac": "Q9JHE5-1", "start_pos": "401", "end_pos": "401", "site_lbl": "Cys401", "weight": 0.0, "mutagenesis": [ { "sequence_org": "C", "sequence_mut": "S", "comment": "Does not affect alanine transport activity.", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" }, { "database": "PubMed", "id": "27355203", "url": "https://glygen.org/publication/PubMed/27355203" } ] } ] }, { "uniprot_canonical_ac": "Q9JHE5-1", "start_pos": "475", "end_pos": "475", "site_lbl": "Cys475", "weight": 0.0, "mutagenesis": [ { "sequence_org": "C", "sequence_mut": "S", "comment": "Significantly decreases alanine transport activity.", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" }, { "database": "PubMed", "id": "27355203", "url": "https://glygen.org/publication/PubMed/27355203" } ] } ] }, { "uniprot_canonical_ac": "Q9JHE5-1", "start_pos": "504", "end_pos": "504", "site_lbl": "His504", "weight": 0.0, "mutagenesis": [ { "sequence_org": "H", "sequence_mut": "A", "comment": "Modifies the transporter pH-sensitivity.", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" }, { "database": "PubMed", "id": "16629640", "url": "https://glygen.org/publication/PubMed/16629640" } ] } ] }, { "uniprot_canonical_ac": "Q9JHE5-1", "start_pos": "82", "end_pos": "82", "site_lbl": "Asn82", "weight": 0.0, "mutagenesis": [ { "sequence_org": "N", "sequence_mut": "A", "comment": "Impairs amino acid transport. Impairs the interaction of SNAT2 with the cotransported sodium ion.", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" }, { "database": "PubMed", "id": "18319257", "url": "https://glygen.org/publication/PubMed/18319257" } ] }, { "sequence_org": "N", "sequence_mut": "S", "comment": "Loss of amino acid transport activity. Loss of amino acid uptake activity. Reduces the amino acid affinity.", "evidence": [ { "database": "UniProtKB", "id": "Q9JHE5", "url": "https://www.uniprot.org/uniprotkb/Q9JHE5" }, { "database": "PubMed", "id": "18319257", "url": "https://glygen.org/publication/PubMed/18319257" } ] } ] } ], "record_id": "Q9JHE5-1" }, { "uniprot_canonical_ac": "Q9JHY2-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q9JHY2", "url": "https://www.uniprot.org/uniprotkb/Q9JHY2" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 321, "chemical_mass": 35465.0, "gene_names": "Sfxn3;SLC64A3;Sfxn3;TCC", "protein_name": "Sideroflexin-3", "disease": [], "cellular_component": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q9JHY2", "url": "https://www.uniprot.org/uniprotkb/Q9JHY2" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q9JHY2", "url": "https://www.uniprot.org/uniprotkb/Q9JHY2" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "Q9JHY2", "url": "https://www.uniprot.org/uniprotkb/Q9JHY2" } ], "pmid": "" } ], "molecular_function": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "Q9JHY2", "url": "https://www.uniprot.org/uniprotkb/Q9JHY2" } ], "pmid": "" }, { "name": "L-serine transmembrane transporter activity", "id": "GO:0015194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015194", "evidence": [ { "database": "UniProtKB", "id": "Q9JHY2", "url": "https://www.uniprot.org/uniprotkb/Q9JHY2" } ], "pmid": "" }, { 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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "Q9R0K8", "url": "https://www.uniprot.org/uniprotkb/Q9R0K8" } ], "pmid": "" }, { "name": "intracellular calcium ion homeostasis", "id": "GO:0006874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006874", "evidence": [ { "database": "UniProtKB", "id": "Q9R0K8", "url": "https://www.uniprot.org/uniprotkb/Q9R0K8" } ], "pmid": "" }, { "name": "cellular response to hypoxia", "id": "GO:0071456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071456", "evidence": [ { "database": "UniProtKB", "id": "Q9R0K8", "url": "https://www.uniprot.org/uniprotkb/Q9R0K8" } ], "pmid": "" }, { "name": "negative regulation of multicellular organism growth", "id": "GO:0040015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0040015", "evidence": [ { "database": "UniProtKB", "id": "Q9R0K8", "url": "https://www.uniprot.org/uniprotkb/Q9R0K8" } ], "pmid": "" }, { "name": "endoplasmic reticulum unfolded protein 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"name": "male gonad development", "id": "GO:0008584", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008584", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "neural tube closure", "id": "GO:0001843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001843", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "anterior/posterior pattern specification", "id": "GO:0009952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009952", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "neural tube development", "id": "GO:0021915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021915", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "negative regulation of cell growth", "id": "GO:0030308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030308", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "negative regulation of BMP signaling pathway", "id": "GO:0030514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030514", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "negative regulation of fibroblast proliferation", "id": "GO:0048147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048147", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "digestive tract morphogenesis", "id": "GO:0048546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048546", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "positive regulation of extrinsic apoptotic signaling pathway", "id": "GO:2001238", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001238", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "hemopoiesis", "id": "GO:0030097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030097", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "somitogenesis", "id": "GO:0001756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001756", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "cellular response to transforming growth factor beta stimulus", "id": "GO:0071560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071560", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "cellular response to BMP stimulus", "id": "GO:0071773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071773", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "negative regulation of Wnt signaling pathway", "id": "GO:0030178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030178", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "canonical Wnt signaling pathway", "id": "GO:0060070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "Wnt signaling pathway, planar cell polarity pathway", "id": "GO:0060071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060071", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "female gonad development", "id": "GO:0008585", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008585", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "regulation of ossification", "id": "GO:0030278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030278", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], 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"Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "negative regulation of JUN kinase activity", "id": "GO:0043508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043508", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "hematopoietic progenitor cell differentiation", "id": "GO:0002244", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002244", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "response to xenobiotic stimulus", "id": "GO:0009410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009410", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "regulation of neuron projection development", "id": "GO:0010975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010975", "evidence": [ { 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formation", "id": "GO:0060346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060346", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "regulation of establishment of planar polarity", "id": "GO:0090175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090175", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "neural crest cell fate commitment", "id": "GO:0014034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014034", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "convergent extension involved in somitogenesis", "id": "GO:0090246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090246", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "regulation of midbrain dopaminergic neuron differentiation", "id": "GO:1904956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904956", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "cellular response to vitamin D", "id": "GO:0071305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071305", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "cellular response to X-ray", "id": "GO:0071481", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071481", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "regulation of cell cycle process", "id": "GO:0010564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010564", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "negative regulation of ossification", "id": "GO:0030279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030279", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "regulation of branching involved in prostate gland morphogenesis", "id": "GO:0060687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060687", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "dorsal/ventral axis specification", "id": "GO:0009950", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009950", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "positive regulation of Wnt signaling pathway", "id": "GO:0030177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030177", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "negative regulation of peptidyl-tyrosine phosphorylation", "id": "GO:0050732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050732", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "negative regulation of epithelial to mesenchymal transition", "id": "GO:0010719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010719", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "dopaminergic neuron differentiation", "id": "GO:0071542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071542", "evidence": [ { "database": "UniProtKB", "id": "Q9R168", "url": "https://www.uniprot.org/uniprotkb/Q9R168" } ], "pmid": "" }, { "name": "negative regulation of androgen receptor signaling pathway", "id": "GO:0060766", "url": 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"species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q9WTZ3", "url": "https://www.uniprot.org/uniprotkb/Q9WTZ3" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 1052, "chemical_mass": 117462.0, "gene_names": "Mbtps1;Mbtps1;S1p;Ski-1;Ski1", "protein_name": "Membrane-bound transcription factor site-1 protease", "disease": [ { "disease_id": "DOID:0060250", "name": "idiopathic scoliosis", "description": "A scoliosis with no known cause.", "url": "https://disease-ontology.org/term/DOID:0060250", "evidence": [ { "id": "0060250", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060250" } ], "weight": 0.0 }, { "disease_id": "DOID:0112283", "name": "spondyloepiphyseal dysplasia Kondo-Fu type", "description": "A spondyloepiphyseal dysplasia that has_material_basis_in homozygous or compound heterozygous mutation in the MBTPS1 gene on chromosome 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"pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUK2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JUK2" } ], "pmid": "" }, { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUK2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JUK2" } ], "pmid": "" }, { "name": "cytoplasmic ribonucleoprotein granule", "id": "GO:0036464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036464", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUK2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JUK2" } ], "pmid": "" }, { "name": "cytoplasmic stress granule", "id": "GO:0010494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010494", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUK2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JUK2" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUK2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JUK2" } ], "pmid": "" }, { "name": "mitotic spindle", "id": "GO:0072686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUK2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JUK2" } ], "pmid": "" } ], "biological_process": [ { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUK2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JUK2" } ], "pmid": "" }, { "name": "mitotic spindle assembly", "id": "GO:0090307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090307", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUK2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JUK2" } ], "pmid": "" }, { "name": "negative regulation of translation", "id": "GO:0017148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017148", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUK2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JUK2" } ], "pmid": "" }, { "name": "P-body assembly", "id": "GO:0033962", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033962", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUK2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JUK2" } ], "pmid": "" }, { "name": "stress granule assembly", "id": "GO:0034063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034063", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUK2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JUK2" } ], "pmid": "" }, { "name": "positive regulation of type I interferon-mediated signaling pathway", "id": "GO:0060340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060340", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUK2", "url": 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to take up oxygen and to release carbon dioxide.", "url": "https://disease-ontology.org/term/DOID:850", "evidence": [ { "id": "850", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:850" } ], "weight": 0.0 } ], "biological_process": [ { "name": "regulation of lipid transport", "id": "GO:0032368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032368", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1Q8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K1Q8" } ], "pmid": "" }, { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1Q8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K1Q8" } ], "pmid": "" }, { "name": "positive regulation of cholesterol efflux", "id": "GO:0010875", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010875", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1Q8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K1Q8" } ], 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"name": "phospholipid homeostasis", "id": "GO:0055091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055091", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1Q8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K1Q8" } ], "pmid": "" }, { "name": "phosphatidylcholine metabolic process", "id": "GO:0046470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046470", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1Q8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K1Q8" } ], "pmid": "" }, { "name": "positive regulation of phospholipid efflux", "id": "GO:1902995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902995", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1Q8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K1Q8" } ], "pmid": "" }, { "name": "xenobiotic transmembrane transport", "id": "GO:0006855", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006855", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1Q8", "url": 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"evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1Q8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K1Q8" } ], "pmid": "" }, { "name": "xenobiotic export from cell", "id": "GO:0046618", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046618", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1Q8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K1Q8" } ], "pmid": "" }, { "name": "positive regulation of phospholipid transport", "id": "GO:2001140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001140", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1Q8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K1Q8" } ], "pmid": "" }, { "name": "xenobiotic transport", "id": "GO:0042908", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042908", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1Q8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K1Q8" } ], "pmid": "" }, { "name": "regulation of phosphatidylcholine metabolic process", "id": "GO:0150172", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150172", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1Q8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K1Q8" } ], "pmid": "" } ], "molecular_function": [ { "name": "lipid transporter activity", "id": "GO:0005319", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005319", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1Q8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K1Q8" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1Q8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K1Q8" } ], "pmid": "" }, { "name": "ATPase-coupled transmembrane transporter activity", "id": "GO:0042626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042626", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1Q8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K1Q8" } ], "pmid": "" }, { "name": "ABC-type xenobiotic 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}, { "name": "ABC-type transporter activity", "id": "GO:0140359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140359", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1Q8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K1Q8" } ], "pmid": "" } ], "cellular_component": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1Q8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K1Q8" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1Q8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K1Q8" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1Q8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K1Q8" } ], 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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K715", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K715" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A0A0G2K715-1" }, { "uniprot_canonical_ac": "A0A0G2K7B6-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7B6", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7B6" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 2134, "chemical_mass": 242462.0, "gene_names": "Dysf;Dysf", "protein_name": "Dysferlin", "disease": [ { "disease_id": "DOID:0070199", "name": "Miyoshi muscular dystrophy 1", "description": "A Miyoshi muscular dystrophy that has_material_basis_in mutation in the DYSF gene on chromosome 2p13.", "url": "https://disease-ontology.org/term/DOID:0070199", "evidence": [ { "id": "0070199", 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"" }, { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "D3Z967", "url": "https://www.uniprot.org/uniprotkb/D3Z967" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "D3Z967-1" }, { "uniprot_canonical_ac": "D3Z9A5-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3Z9A5", "url": "https://www.uniprot.org/uniprotkb/D3Z9A5" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 724, "chemical_mass": 79273.0, "gene_names": "Btbd18;Btbd18", "protein_name": "BTB/POZ domain-containing protein 18", "disease": [], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "D3Z9A5", "url": 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"url": "https://www.uniprot.org/uniprotkb/D3Z9A5" } ], "pmid": "" }, { "name": "transposable element silencing", "id": "GO:0010526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010526", "evidence": [ { "database": "UniProtKB", "id": "D3Z9A5", "url": "https://www.uniprot.org/uniprotkb/D3Z9A5" } ], "pmid": "" }, { "name": "piRNA transcription", "id": "GO:0140541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140541", "evidence": [ { "database": "UniProtKB", "id": "D3Z9A5", "url": "https://www.uniprot.org/uniprotkb/D3Z9A5" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "D3Z9A5-1" }, { "uniprot_canonical_ac": "D3Z9E5-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3Z9E5", "url": "https://www.uniprot.org/uniprotkb/D3Z9E5" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 611, "chemical_mass": 66422.0, "gene_names": 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"D3Z9E5", "url": "https://www.uniprot.org/uniprotkb/D3Z9E5" } ], "pmid": "" }, { "name": "pyruvate transport", "id": "GO:0006848", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006848", "evidence": [ { "database": "UniProtKB", "id": "D3Z9E5", "url": "https://www.uniprot.org/uniprotkb/D3Z9E5" } ], "pmid": "" }, { "name": "nitrate transmembrane transport", "id": "GO:0015706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015706", "evidence": [ { "database": "UniProtKB", "id": "D3Z9E5", "url": "https://www.uniprot.org/uniprotkb/D3Z9E5" } ], "pmid": "" }, { "name": "propanoate transmembrane transport", "id": "GO:0015730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015730", "evidence": [ { "database": "UniProtKB", "id": "D3Z9E5", "url": "https://www.uniprot.org/uniprotkb/D3Z9E5" } ], "pmid": "" }, { "name": "acetate transport", "id": "GO:0006846", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006846", "evidence": [ { "database": "UniProtKB", "id": "D3Z9E5", "url": 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"D3Z9F7-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3Z9F7", "url": "https://www.uniprot.org/uniprotkb/D3Z9F7" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 1406, "chemical_mass": 155261.0, "gene_names": "Cr2;Cd21;Cr2", "protein_name": "Complement component receptor 1-like protein", "disease": [ { "disease_id": "DOID:0081150", "name": "common variable immunodeficiency 7", "description": "A common variable immunodeficiency that has_material_basis_in compound heterozygous mutation in the CD21 gene (CR2) on chromosome 1q32.", "url": "https://disease-ontology.org/term/DOID:0081150", "evidence": [ { "id": "0081150", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0081150" } ], "weight": 0.0 }, { "disease_id": "DOID:526", "name": "human immunodeficiency virus infectious disease", "description": "A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 (Lentivirus humimdef1) or Human immunodeficiency virus 2 (Lentivirus humimdef2), which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.", "url": "https://disease-ontology.org/term/DOID:526", "evidence": [ { "id": "526", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:526" } ], "weight": 0.0 }, { "disease_id": "DOID:9074", "name": "systemic lupus erythematosus", "description": "A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.", "url": "https://disease-ontology.org/term/DOID:9074", "evidence": [ { "id": "9074", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9074" } ], "weight": 0.0 }, { "disease_id": "DOID:9261", "name": "nasopharynx carcinoma", "description": "A pharynx cancer that is located in the nasopharynx, the uppermost region of the pharynx or throat, where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.", "url": "https://disease-ontology.org/term/DOID:9261", "evidence": [ { "id": "9261", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9261" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "immunoglobulin receptor binding", "id": "GO:0034987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034987", "evidence": [ { "database": "UniProtKB", "id": "D3Z9F7", "url": "https://www.uniprot.org/uniprotkb/D3Z9F7" } ], "pmid": "" }, { "name": "complement receptor activity", "id": "GO:0004875", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004875", "evidence": [ { "database": "UniProtKB", "id": "D3Z9F7", "url": "https://www.uniprot.org/uniprotkb/D3Z9F7" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "D3Z9F7", "url": "https://www.uniprot.org/uniprotkb/D3Z9F7" } ], "pmid": "" }, { "name": "transmembrane signaling receptor activity", "id": "GO:0004888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "evidence": [ { "database": "UniProtKB", "id": "D3Z9F7", "url": "https://www.uniprot.org/uniprotkb/D3Z9F7" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "D3Z9F7", "url": "https://www.uniprot.org/uniprotkb/D3Z9F7" } ], "pmid": "" }, { "name": "complement binding", "id": "GO:0001848", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001848", "evidence": [ { "database": "UniProtKB", "id": "D3Z9F7", "url": "https://www.uniprot.org/uniprotkb/D3Z9F7" } ], "pmid": "" }, { "name": "signaling receptor activity", "id": "GO:0038023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "database": "UniProtKB", "id": "D3Z9F7", "url": "https://www.uniprot.org/uniprotkb/D3Z9F7" } ], "pmid": "" } ], "cellular_component": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "D3Z9F7", "url": "https://www.uniprot.org/uniprotkb/D3Z9F7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "D3Z9F7", "url": "https://www.uniprot.org/uniprotkb/D3Z9F7" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "D3Z9F7", "url": "https://www.uniprot.org/uniprotkb/D3Z9F7" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "D3Z9F7", "url": 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"url": "https://www.uniprot.org/uniprotkb/D3Z9F7" } ], "pmid": "" }, { "name": "cellular response to lipopolysaccharide", "id": "GO:0071222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071222", "evidence": [ { "database": "UniProtKB", "id": "D3Z9F7", "url": "https://www.uniprot.org/uniprotkb/D3Z9F7" } ], "pmid": "" }, { "name": "female pregnancy", "id": "GO:0007565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007565", "evidence": [ { "database": "UniProtKB", "id": "D3Z9F7", "url": "https://www.uniprot.org/uniprotkb/D3Z9F7" } ], "pmid": "" }, { "name": "B cell differentiation", "id": "GO:0030183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030183", "evidence": [ { "database": "UniProtKB", "id": "D3Z9F7", "url": "https://www.uniprot.org/uniprotkb/D3Z9F7" } ], "pmid": "" }, { "name": "symbiont entry into host cell", "id": "GO:0046718", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046718", "evidence": [ { "database": "UniProtKB", "id": "D3Z9F7", "url": 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"longitudinal sarcoplasmic reticulum", "id": "GO:0014801", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014801", "evidence": [ { "database": "UniProtKB", "id": "D3ZGP9", "url": "https://www.uniprot.org/uniprotkb/D3ZGP9" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "D3ZGP9-1" }, { "uniprot_canonical_ac": "D3ZGS1-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZGS1", "url": "https://www.uniprot.org/uniprotkb/D3ZGS1" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 779, "chemical_mass": 88681.0, "gene_names": "Vom2r54", "protein_name": "", "disease": [], "molecular_function": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "D3ZGS1", "url": "https://www.uniprot.org/uniprotkb/D3ZGS1" } ], "pmid": "" } ], "cellular_component": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "D3ZGS1", "url": "https://www.uniprot.org/uniprotkb/D3ZGS1" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "D3ZGS1-1" }, { "uniprot_canonical_ac": "D3ZGX8-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZGX8", "url": "https://www.uniprot.org/uniprotkb/D3ZGX8" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 1619, "chemical_mass": 177803.0, "gene_names": "Brd4", "protein_name": "", "disease": [ { "disease_id": "DOID:0050156", "name": "idiopathic pulmonary fibrosis", "description": "A pulmonary fibrosis that is characterized by scarring of the lung characterized by stiffness in the lungs and makes it difficult to breathe.", "url": 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"name": "rheumatic heart disease", "description": "A heart valve disease that is characterized by repeated inflammation with fibrinous repair caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords.", "url": "https://disease-ontology.org/term/DOID:0050827", "evidence": [ { "id": "0050827", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050827" } ], "weight": 0.0 }, { "disease_id": "DOID:0080599", "name": "Coronavirus infectious disease", "description": "A viral infectious disease that has_material_basis_in Coronavirus.", "url": "https://disease-ontology.org/term/DOID:0080599", "evidence": [ { "id": "0080599", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080599" } ], "weight": 0.0 }, { "disease_id": "DOID:11650", "name": "bronchopulmonary dysplasia", "description": "A lung disease that is characterized by underdeveloped lungs in newborns that can be easily irritated or inflamed after birth resulting in damage to the alveoli of the lungs and bronchi. 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The infection has symptom fever, has symptom severe headache, has symptom severe pain behind the eyes, has symptom joint pain, has symptom muscle and bone pain, has symptom rash, and has symptom mild bleeding.", "url": "https://disease-ontology.org/term/DOID:12205", "evidence": [ { "id": "12205", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12205" } ], "weight": 0.0 }, { "disease_id": "DOID:12206", "name": "dengue hemorrhagic fever", "description": "A dengue disease that occurs when a person experiences a second infection with a heterologous Dengue virus (Orthoflavivirus denguei) serotype, which is transmitted_by Aedes mosquito bite. The infection has_symptom hemorrhagic lesions of the skin, has_symptom thrombocytopenia, has_symptom reduction in the fluid part of the blood, and has_symptom high fever. Four distinct Dengue virus serotypes have been identified.", "url": "https://disease-ontology.org/term/DOID:12206", "evidence": [ { "id": "12206", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12206" } ], "weight": 0.0 }, { "disease_id": "DOID:13564", "name": "aspergillosis", "description": "An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney, heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.", "url": "https://disease-ontology.org/term/DOID:13564", "evidence": [ { "id": "13564", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13564" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:2957", "name": "pulmonary tuberculosis", "description": "A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis.", "url": "https://disease-ontology.org/term/DOID:2957", "evidence": [ { "id": "2957", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2957" } ], "weight": 0.0 }, { "disease_id": "DOID:399", "name": "tuberculosis", "description": "A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.", "url": "https://disease-ontology.org/term/DOID:399", "evidence": [ { "id": "399", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:399" } ], "weight": 0.0 }, { "disease_id": "DOID:526", "name": "human immunodeficiency virus infectious disease", "description": "A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 (Lentivirus humimdef1) or Human immunodeficiency virus 2 (Lentivirus humimdef2), which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.", "url": "https://disease-ontology.org/term/DOID:526", "evidence": [ { "id": "526", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:526" } ], "weight": 0.0 }, { "disease_id": "DOID:635", "name": "acquired immunodeficiency syndrome", "description": "A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per microliter of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 (Lentivirus humimdef1) or Human immunodeficiency virus 2 (Lentivirus humimdef2), which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS.", "url": "https://disease-ontology.org/term/DOID:635", "evidence": [ { "id": "635", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:635" } ], "weight": 0.0 }, { "disease_id": "DOID:6432", "name": "pulmonary hypertension", "description": "A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries.", "url": "https://disease-ontology.org/term/DOID:6432", "evidence": [ { "id": "6432", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6432" } ], "weight": 0.0 } ], "biological_process": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "D3ZP17", "url": "https://www.uniprot.org/uniprotkb/D3ZP17" } ], "pmid": "" } ], "cellular_component": [ { "name": "cell surface", "id": "GO:0009986", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "D3ZP48", "url": "https://www.uniprot.org/uniprotkb/D3ZP48" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "D3ZP48-1" }, { "uniprot_canonical_ac": "D3ZPA7-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZPA7", "url": "https://www.uniprot.org/uniprotkb/D3ZPA7" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 606, "chemical_mass": 65339.0, "gene_names": "Scara3;Scara3", "protein_name": "", "disease": [], "cellular_component": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "D3ZPA7", "url": "https://www.uniprot.org/uniprotkb/D3ZPA7" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": 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"url": "https://www.uniprot.org/uniprotkb/D3ZPB6" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 408, "chemical_mass": 47886.0, "gene_names": "Ust;Ust", "protein_name": "Uronyl 2-sulfotransferase", "disease": [ { "disease_id": "DOID:1094", "name": "attention deficit hyperactivity disorder", "description": "A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone and symptoms starting before seven years of age.", "url": "https://disease-ontology.org/term/DOID:1094", "evidence": [ { "id": "1094", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1094" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "sulfotransferase activity", "id": "GO:0008146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008146", "evidence": [ { "database": "UniProtKB", "id": "D3ZPB6", "url": 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"protein insertion into mitochondrial inner membrane from matrix", "id": "GO:0032979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032979", "evidence": [ { "database": "UniProtKB", "id": "D3ZRH1", "url": "https://www.uniprot.org/uniprotkb/D3ZRH1" } ], "pmid": "" }, { "name": "mitochondrial protein quality control", "id": "GO:0141164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141164", "evidence": [ { "database": "UniProtKB", "id": "D3ZRH1", "url": "https://www.uniprot.org/uniprotkb/D3ZRH1" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "D3ZRH1-1" }, { "uniprot_canonical_ac": "D3ZRL3-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZRL3", "url": "https://www.uniprot.org/uniprotkb/D3ZRL3" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 150, "chemical_mass": 16560.0, "gene_names": "Dusp23;Dusp23", "protein_name": "Dual specificity protein phosphatase 23", "disease": [], "biological_process": [ { "name": "dephosphorylation", "id": "GO:0016311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016311", "evidence": [ { "database": "UniProtKB", "id": "D3ZRL3", "url": "https://www.uniprot.org/uniprotkb/D3ZRL3" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "D3ZRL3", "url": "https://www.uniprot.org/uniprotkb/D3ZRL3" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "D3ZRL3", "url": "https://www.uniprot.org/uniprotkb/D3ZRL3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "D3ZRL3", "url": "https://www.uniprot.org/uniprotkb/D3ZRL3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "D3ZRL3", "url": "https://www.uniprot.org/uniprotkb/D3ZRL3" } ], "pmid": "" } ], "molecular_function": [ { "name": "protein serine/threonine phosphatase activity", "id": "GO:0004722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004722", "evidence": [ { "database": "UniProtKB", "id": "D3ZRL3", "url": "https://www.uniprot.org/uniprotkb/D3ZRL3" } ], "pmid": "" }, { "name": "protein tyrosine/serine/threonine phosphatase activity", "id": "GO:0008138", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008138", "evidence": [ { "database": "UniProtKB", "id": "D3ZRL3", "url": "https://www.uniprot.org/uniprotkb/D3ZRL3" } ], "pmid": "" }, { "name": "phosphatase activity", "id": "GO:0016791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016791", "evidence": [ { "database": "UniProtKB", "id": "D3ZRL3", "url": "https://www.uniprot.org/uniprotkb/D3ZRL3" } ], "pmid": "" }, { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "D3ZRL3", "url": "https://www.uniprot.org/uniprotkb/D3ZRL3" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "D3ZRL3-1" }, { "uniprot_canonical_ac": "D3ZRW4-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZRW4", "url": "https://www.uniprot.org/uniprotkb/D3ZRW4" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 511, "chemical_mass": 58006.0, "gene_names": "Kcna10;Kcna10", "protein_name": "Potassium voltage-gated channel subfamily A member 10", "disease": [ { "disease_id": "DOID:0050989", "name": "episodic ataxia type 1", "description": "An episodic ataxia that is characterized by periodic ataxia and frequent myokymic discharges, and has_material_basis_in autosomal dominant inheritance of mutation in the potassium channel gene KCNA1.", "url": "https://disease-ontology.org/term/DOID:0050989", "evidence": [ { "id": "0050989", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050989" } ], "weight": 0.0 }, { "disease_id": "DOID:1826", "name": "epilepsy", "description": "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions.", "url": "https://disease-ontology.org/term/DOID:1826", "evidence": [ { "id": "1826", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1826" } ], "weight": 0.0 }, { "disease_id": "DOID:3426", "name": "vestibular disease", "description": "An inner ear disease that is located in the vestibular system.", "url": "https://disease-ontology.org/term/DOID:3426", "evidence": [ { "id": "3426", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3426" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "delayed rectifier potassium channel activity", "id": "GO:0005251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005251", "evidence": [ { "database": "UniProtKB", "id": "D3ZRW4", "url": "https://www.uniprot.org/uniprotkb/D3ZRW4" } ], "pmid": "" }, { "name": "voltage-gated potassium channel activity", "id": "GO:0005249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005249", "evidence": [ { "database": "UniProtKB", "id": "D3ZRW4", "url": "https://www.uniprot.org/uniprotkb/D3ZRW4" } ], "pmid": "" } ], "cellular_component": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "D3ZRW4", "url": "https://www.uniprot.org/uniprotkb/D3ZRW4" } ], "pmid": "" }, { "name": "voltage-gated potassium channel complex", "id": "GO:0008076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008076", "evidence": [ { "database": "UniProtKB", "id": "D3ZRW4", "url": "https://www.uniprot.org/uniprotkb/D3ZRW4" } ], "pmid": "" } ], "biological_process": [ { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "D3ZRW4", "url": "https://www.uniprot.org/uniprotkb/D3ZRW4" } ], "pmid": "" }, { "name": "action potential", "id": "GO:0001508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001508", "evidence": [ { "database": "UniProtKB", "id": "D3ZRW4", "url": "https://www.uniprot.org/uniprotkb/D3ZRW4" } ], "pmid": "" }, { "name": "potassium ion transport", "id": "GO:0006813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006813", "evidence": [ { "database": "UniProtKB", "id": "D3ZRW4", "url": "https://www.uniprot.org/uniprotkb/D3ZRW4" } ], "pmid": "" }, { "name": "potassium ion transmembrane transport", "id": "GO:0071805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "evidence": [ { "database": "UniProtKB", "id": "D3ZRW4", "url": "https://www.uniprot.org/uniprotkb/D3ZRW4" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "D3ZRW4-1" }, { "uniprot_canonical_ac": "D3ZRW9-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZRW9", "url": "https://www.uniprot.org/uniprotkb/D3ZRW9" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 248, "chemical_mass": 26978.0, "gene_names": "Gzmn;Gzmn;RGD1564878", "protein_name": "", "disease": [ { "disease_id": "DOID:0080600", "name": "COVID-19", "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum.", "url": "https://disease-ontology.org/term/DOID:0080600", "evidence": [ { "id": "0080600", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080600" } ], "weight": 0.0 }, { "disease_id": "DOID:2799", "name": "bronchiolitis obliterans", "description": "A obstructive lung disease involving obstruction of the bronchioles due to inflammation and fibrosis which occurs as a complication of various lung conditions or physiological insults.", "url": "https://disease-ontology.org/term/DOID:2799", "evidence": [ { "id": "2799", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2799" } ], "weight": 0.0 }, { "disease_id": "DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "D3ZRW9", "url": "https://www.uniprot.org/uniprotkb/D3ZRW9" } ], "pmid": "" } ], "biological_process": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "D3ZRW9", "url": "https://www.uniprot.org/uniprotkb/D3ZRW9" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "D3ZRW9-1" }, { "uniprot_canonical_ac": "D3ZS25-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZS25", "url": "https://www.uniprot.org/uniprotkb/D3ZS25" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 209, "chemical_mass": 23997.0, "gene_names": "Hmgb2l2;AABR07015743.1;Hmgb2l2;RGD1561694", "protein_name": "High mobility group protein B2", "disease": [], "cellular_component": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "D3ZS25", "url": "https://www.uniprot.org/uniprotkb/D3ZS25" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "D3ZS25", "url": "https://www.uniprot.org/uniprotkb/D3ZS25" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "D3ZS25", "url": "https://www.uniprot.org/uniprotkb/D3ZS25" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "D3ZS25", "url": "https://www.uniprot.org/uniprotkb/D3ZS25" } ], "pmid": "" } ], "biological_process": [ { "name": "DNA recombination", "id": "GO:0006310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006310", "evidence": [ { "database": "UniProtKB", "id": "D3ZS25", "url": "https://www.uniprot.org/uniprotkb/D3ZS25" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "D3ZS25", "url": "https://www.uniprot.org/uniprotkb/D3ZS25" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "D3ZS25", "url": "https://www.uniprot.org/uniprotkb/D3ZS25" } ], "pmid": "" }, { "name": "chemotaxis", "id": "GO:0006935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006935", "evidence": [ { "database": "UniProtKB", "id": "D3ZS25", "url": "https://www.uniprot.org/uniprotkb/D3ZS25" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "D3ZS25", "url": "https://www.uniprot.org/uniprotkb/D3ZS25" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "D3ZS25", "url": "https://www.uniprot.org/uniprotkb/D3ZS25" } ], "pmid": "" }, { "name": "response to lipopolysaccharide", "id": "GO:0032496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032496", "evidence": [ { "database": "UniProtKB", "id": "D3ZS25", "url": "https://www.uniprot.org/uniprotkb/D3ZS25" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "D3ZS25", "url": "https://www.uniprot.org/uniprotkb/D3ZS25" } ], "pmid": "" }, { "name": "defense response to Gram-negative bacterium", "id": "GO:0050829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050829", "evidence": [ { "database": "UniProtKB", "id": "D3ZS25", "url": "https://www.uniprot.org/uniprotkb/D3ZS25" } ], "pmid": "" }, { "name": "defense response to Gram-positive bacterium", "id": "GO:0050830", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050830", "evidence": [ { "database": "UniProtKB", "id": "D3ZS25", "url": "https://www.uniprot.org/uniprotkb/D3ZS25" } ], "pmid": "" }, { "name": "inflammatory response to antigenic stimulus", "id": "GO:0002437", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002437", "evidence": [ { "database": "UniProtKB", "id": "D3ZS25", "url": "https://www.uniprot.org/uniprotkb/D3ZS25" } ], "pmid": "" }, { "name": "regulation of stem cell proliferation", "id": "GO:0072091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072091", "evidence": [ { "database": "UniProtKB", "id": "D3ZS25", "url": "https://www.uniprot.org/uniprotkb/D3ZS25" } ], "pmid": "" }, { "name": "regulation of neurogenesis", "id": "GO:0050767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050767", "evidence": [ { "database": "UniProtKB", "id": "D3ZS25", "url": "https://www.uniprot.org/uniprotkb/D3ZS25" } ], "pmid": "" } ], "molecular_function": [ { "name": "cis-regulatory region sequence-specific DNA binding", "id": "GO:0000987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000987", "evidence": [ { "database": "UniProtKB", "id": "D3ZS25", "url": "https://www.uniprot.org/uniprotkb/D3ZS25" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "D3ZS25-1" }, { "uniprot_canonical_ac": "D3ZS39-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZS39", "url": "https://www.uniprot.org/uniprotkb/D3ZS39" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 1240, "chemical_mass": 141432.0, "gene_names": "Mms22l;Mms22l;RGD1304693", "protein_name": "Protein MMS22-like", "disease": [], "cellular_component": [ { "name": "nuclear replication fork", "id": "GO:0043596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043596", "evidence": [ { "database": "UniProtKB", "id": "D3ZS39", "url": "https://www.uniprot.org/uniprotkb/D3ZS39" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "D3ZS39", "url": "https://www.uniprot.org/uniprotkb/D3ZS39" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "D3ZS39", "url": "https://www.uniprot.org/uniprotkb/D3ZS39" } ], "pmid": "" }, { "name": "site of double-strand break", "id": "GO:0035861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", "evidence": [ { "database": "UniProtKB", "id": "D3ZS39", "url": "https://www.uniprot.org/uniprotkb/D3ZS39" } ], "pmid": "" }, { "name": "FACT complex", "id": "GO:0035101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035101", "evidence": [ { "database": "UniProtKB", "id": "D3ZS39", "url": "https://www.uniprot.org/uniprotkb/D3ZS39" } ], "pmid": "" }, { "name": "MCM complex", "id": "GO:0042555", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042555", "evidence": [ { "database": "UniProtKB", "id": "D3ZS39", "url": "https://www.uniprot.org/uniprotkb/D3ZS39" } ], "pmid": "" }, { "name": "site of DNA damage", "id": "GO:0090734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090734", "evidence": [ { "database": "UniProtKB", "id": "D3ZS39", "url": 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"name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZZV5", "url": "https://www.uniprot.org/uniprotkb/D3ZZV5" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 316, "chemical_mass": 35843.0, "gene_names": "Jmjd7;Jmjd7", "protein_name": "Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7", "disease": [ { "disease_id": "DOID:1574", "name": "alcohol use disorder", "description": "A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.", "url": "https://disease-ontology.org/term/DOID:1574", "evidence": [ { "id": "1574", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1574" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "endopeptidase activity", "id": "GO:0004175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004175", "evidence": [ { "database": "UniProtKB", "id": "D3ZZV5", "url": 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"https://www.uniprot.org/uniprotkb/D3ZZV5" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "D3ZZV5-1" }, { "uniprot_canonical_ac": "D4A0T8-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D4A0T8", "url": "https://www.uniprot.org/uniprotkb/D4A0T8" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 338, "chemical_mass": 38311.0, "gene_names": "Dhrs7;Dhrs7;RGD1565002", "protein_name": "", "disease": [], "cellular_component": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "D4A0T8", "url": "https://www.uniprot.org/uniprotkb/D4A0T8" } ], "pmid": "" } ], "molecular_function": [ { "name": "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "id": "GO:0016616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016616", "evidence": [ { "database": "UniProtKB", "id": "D4A0T8", "url": "https://www.uniprot.org/uniprotkb/D4A0T8" } ], "pmid": "" }, { "name": "all-trans-retinol dehydrogenase (NADP+) activity", "id": "GO:0052650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052650", "evidence": [ { "database": "UniProtKB", "id": "D4A0T8", "url": "https://www.uniprot.org/uniprotkb/D4A0T8" } ], "pmid": "" }, { "name": "carbonyl reductase (NADPH) activity", "id": "GO:0004090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004090", "evidence": [ { "database": "UniProtKB", "id": "D4A0T8", "url": "https://www.uniprot.org/uniprotkb/D4A0T8" } ], "pmid": "" }, { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "D4A0T8", "url": "https://www.uniprot.org/uniprotkb/D4A0T8" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "D4A0T8-1" }, { "uniprot_canonical_ac": "D4A0V7-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D4A0V7", "url": "https://www.uniprot.org/uniprotkb/D4A0V7" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 448, "chemical_mass": 52022.0, "gene_names": "Catsper4;Catsper4;RGD1565213", "protein_name": "", "disease": [], "cellular_component": [ { "name": "CatSper complex", "id": "GO:0036128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036128", "evidence": [ { "database": "UniProtKB", "id": "D4A0V7", "url": "https://www.uniprot.org/uniprotkb/D4A0V7" } ], "pmid": "" }, { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "D4A0V7", "url": "https://www.uniprot.org/uniprotkb/D4A0V7" } ], "pmid": "" }, { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "D4A0V7", "url": "https://www.uniprot.org/uniprotkb/D4A0V7" } ], "pmid": "" } ], "biological_process": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "D4A0V7", "url": "https://www.uniprot.org/uniprotkb/D4A0V7" } ], "pmid": "" }, { "name": "sperm capacitation", "id": "GO:0048240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048240", "evidence": [ { "database": "UniProtKB", "id": "D4A0V7", "url": "https://www.uniprot.org/uniprotkb/D4A0V7" } ], "pmid": "" }, { "name": "sodium ion transport", "id": "GO:0006814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006814", "evidence": [ { "database": "UniProtKB", "id": "D4A0V7", "url": "https://www.uniprot.org/uniprotkb/D4A0V7" } ], "pmid": "" } ], "molecular_function": [ { "name": "calcium-activated cation channel activity", "id": "GO:0005227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005227", "evidence": [ { "database": "UniProtKB", "id": "D4A0V7", "url": "https://www.uniprot.org/uniprotkb/D4A0V7" } ], "pmid": "" }, { "name": "voltage-gated calcium channel activity", "id": "GO:0005245", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005245", "evidence": [ { "database": "UniProtKB", "id": "D4A0V7", "url": "https://www.uniprot.org/uniprotkb/D4A0V7" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "D4A0V7-1" }, { "uniprot_canonical_ac": "D4A0Y6-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D4A0Y6", "url": "https://www.uniprot.org/uniprotkb/D4A0Y6" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 3121, "chemical_mass": 343696.0, "gene_names": "Mki67", "protein_name": "", "disease": [ { "disease_id": "DOID:0050745", "name": "diffuse large B-cell lymphoma", "description": "A large B-cell lymphoma that is consisting of medium-sized to large B cells with a diffuse growth pattern.", "url": "https://disease-ontology.org/term/DOID:0050745", "evidence": [ { "id": "0050745", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050745" } ], "weight": 0.0 }, { "disease_id": "DOID:0080178", "name": "mucositis", "description": "A gastrointestinal system disease that is characterized by painful inflammation and ulceration of the mucous membranes lining the digestive tract.", "url": "https://disease-ontology.org/term/DOID:0080178", "evidence": [ { "id": "0080178", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080178" } ], "weight": 0.0 }, { "disease_id": "DOID:0081267", "name": "graft-versus-host disease", "description": "An immune system disease that is characterized by recognition by mature donor T cells, that contaminate the allogeneic bone marrow, of the recipient's tissue as foreign, causing a severe inflammatory disease characterized by rashes, diarrhea, and liver disease, and that has_material_basis_in an associated with variation in the interleukin-10 gene (IL10) on chromosome 1q32.", "url": "https://disease-ontology.org/term/DOID:0081267", "evidence": [ { "id": "0081267", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0081267" } ], "weight": 0.0 }, { "disease_id": "DOID:10286", "name": "prostate carcinoma", "description": "A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.", "url": "https://disease-ontology.org/term/DOID:10286", "evidence": [ { "id": "10286", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10286" } ], "weight": 0.0 }, { "disease_id": "DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach.", "url": "https://disease-ontology.org/term/DOID:10534", "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ], "weight": 0.0 }, { "disease_id": "DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder.", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ], "weight": 0.0 }, { "disease_id": "DOID:1227", "name": "neutropenia", "description": "", "url": "https://disease-ontology.org/term/DOID:1227", "evidence": [ { "id": "1227", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1227" } ], "weight": 0.0 }, { "disease_id": "DOID:127", "name": "leiomyoma", "description": "A cell type benign neoplasm that is a benign tumor of smooth muscle cells.", "url": "https://disease-ontology.org/term/DOID:127", "evidence": [ { "id": "127", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:127" } ], "weight": 0.0 }, { "disease_id": "DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung.", "url": "https://disease-ontology.org/term/DOID:1324", "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ], "weight": 0.0 }, { "disease_id": "DOID:13949", "name": "interstitial cystitis", "description": "", "url": "https://disease-ontology.org/term/DOID:13949", "evidence": [ { "id": "13949", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13949" } ], "weight": 0.0 }, { "disease_id": "DOID:1574", "name": "alcohol use disorder", "description": "A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.", "url": "https://disease-ontology.org/term/DOID:1574", "evidence": [ { "id": "1574", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1574" } ], "weight": 0.0 }, { "disease_id": "DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland.", "url": "https://disease-ontology.org/term/DOID:1612", "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ], "weight": 0.0 }, { "disease_id": "DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas.", "url": "https://disease-ontology.org/term/DOID:1793", "evidence": [ { "id": "1793", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ], "weight": 0.0 }, { "disease_id": "DOID:219", "name": "colon cancer", "description": "A colorectal cancer that is located_in the colon.", "url": "https://disease-ontology.org/term/DOID:219", "evidence": [ { "id": "219", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:219" } ], "weight": 0.0 }, { "disease_id": "DOID:3070", "name": "high grade glioma", "description": "A cell type cancer that has_material_basis_in glial cells and is located in brain or located in spine.", "url": "https://disease-ontology.org/term/DOID:3070", "evidence": [ { "id": "3070", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3070" } ], "weight": 0.0 }, { "disease_id": "DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.", "url": "https://disease-ontology.org/term/DOID:3908", "evidence": [ { "id": "3908", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ], "weight": 0.0 }, { "disease_id": "DOID:3910", "name": "lung adenocarcinoma", "description": "A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:3910", "evidence": [ { "id": "3910", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3910" } ], "weight": 0.0 }, { "disease_id": "DOID:4947", "name": "cholangiocarcinoma", "description": "A bile duct adenocarcinoma that has_material_basis_in bile duct epithelial cells.", "url": "https://disease-ontology.org/term/DOID:4947", "evidence": [ { "id": "4947", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4947" } ], "weight": 0.0 }, { "disease_id": "DOID:5031", "name": "adult pineal parenchymal tumor", "description": "", "url": "https://disease-ontology.org/term/DOID:5031", "evidence": [ { "id": "5031", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5031" } ], "weight": 0.0 }, { "disease_id": "DOID:526", "name": "human immunodeficiency virus infectious disease", "description": "A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 (Lentivirus humimdef1) or Human immunodeficiency virus 2 (Lentivirus humimdef2), which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.", "url": "https://disease-ontology.org/term/DOID:526", "evidence": [ { "id": "526", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:526" } ], "weight": 0.0 }, { "disease_id": "DOID:557", "name": "kidney disease", "description": "A urinary system disease that is located_in the kidney.", "url": "https://disease-ontology.org/term/DOID:557", "evidence": [ { "id": "557", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:557" } ], "weight": 0.0 }, { "disease_id": "DOID:687", "name": "hepatoblastoma", "description": "", "url": "https://disease-ontology.org/term/DOID:687", "evidence": [ { "id": "687", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:687" } ], "weight": 0.0 }, { "disease_id": "DOID:8719", "name": "in situ carcinoma", "description": "A carcinoma that is an early development defined by the absence of invasion of surrounding tissues.", "url": "https://disease-ontology.org/term/DOID:8719", "evidence": [ { "id": "8719", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8719" } ], "weight": 0.0 }, { "disease_id": "DOID:8778", "name": "Crohn's disease", "description": "An intestinal disease that involves inflammation located_in intestine.", "url": "https://disease-ontology.org/term/DOID:8778", "evidence": [ { "id": "8778", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8778" } ], "weight": 0.0 }, { "disease_id": "DOID:8893", "name": "psoriasis", "description": "A skin disease that is characterized by patches of thick red skin and silvery scales.", "url": "https://disease-ontology.org/term/DOID:8893", "evidence": [ { "id": "8893", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8893" 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"url": "https://www.uniprot.org/uniprotkb/F1M6S6" } ], "pmid": "" }, { "name": "ventricular cardiac muscle tissue development", "id": "GO:0003229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003229", "evidence": [ { "database": "UniProtKB", "id": "F1M6S6", "url": "https://www.uniprot.org/uniprotkb/F1M6S6" } ], "pmid": "" }, { "name": "response to bisphenol A", "id": "GO:1903925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903925", "evidence": [ { "database": "UniProtKB", "id": "F1M6S6", "url": "https://www.uniprot.org/uniprotkb/F1M6S6" } ], "pmid": "" }, { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "F1M6S6", "url": "https://www.uniprot.org/uniprotkb/F1M6S6" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "F1M6S6", "url": "https://www.uniprot.org/uniprotkb/F1M6S6" } ], "pmid": "" }, { "name": "determination of left/right symmetry", "id": "GO:0007368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007368", "evidence": [ { "database": "UniProtKB", "id": "F1M6S6", "url": "https://www.uniprot.org/uniprotkb/F1M6S6" } ], "pmid": "" }, { "name": "epithelial cilium movement involved in determination of left/right asymmetry", "id": "GO:0060287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060287", "evidence": [ { "database": "UniProtKB", "id": "F1M6S6", "url": "https://www.uniprot.org/uniprotkb/F1M6S6" } ], "pmid": "" }, { "name": "manchette assembly", "id": "GO:1905198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905198", "evidence": [ { "database": "UniProtKB", "id": "F1M6S6", "url": "https://www.uniprot.org/uniprotkb/F1M6S6" } ], "pmid": "" }, { "name": "cerebrospinal fluid circulation", "id": "GO:0090660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090660", "evidence": [ { "database": 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"D4AAC3-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D4AAC3", "url": "https://www.uniprot.org/uniprotkb/D4AAC3" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 289, "chemical_mass": 33426.0, "gene_names": "Sh3bgr", "protein_name": "", "disease": [], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "D4AAC3", "url": "https://www.uniprot.org/uniprotkb/D4AAC3" } ], "pmid": "" } ], "molecular_function": [ { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "D4AAC3", "url": "https://www.uniprot.org/uniprotkb/D4AAC3" } ], "pmid": "" }, { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": 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"taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "M0RBH7", "url": "https://www.uniprot.org/uniprotkb/M0RBH7" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 822, "chemical_mass": 93387.0, "gene_names": "Ttc16;Ttc16", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "M0RBH7-1" }, { "uniprot_canonical_ac": "M0R3T8-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "M0R3T8", "url": "https://www.uniprot.org/uniprotkb/M0R3T8" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 1675, "chemical_mass": 191346.0, "gene_names": "Ankrd26;Ankrd26;RGD1310736", "protein_name": "", "disease": [ { "disease_id": "DOID:1588", "name": "thrombocytopenia", "description": "A blood platelet disease that is characterized by low a platelet count in the blood.", "url": "https://disease-ontology.org/term/DOID:1588", "evidence": [ { "id": "1588", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1588" } ], "weight": 0.0 }, { "disease_id": "DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.", "url": "https://disease-ontology.org/term/DOID:9970", "evidence": [ { "id": "9970", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9970" } ], "weight": 0.0 } ], "biological_process": [ { "name": "negative regulation of insulin receptor signaling pathway", "id": "GO:0046627", "url": 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"id": "GO:0160258", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160258", "evidence": [ { "database": "UniProtKB", "id": "F1LRE5", "url": "https://www.uniprot.org/uniprotkb/F1LRE5" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "F1LRE5-1" }, { "uniprot_canonical_ac": "D4A8G5-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D4A8G5", "url": "https://www.uniprot.org/uniprotkb/D4A8G5" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 685, "chemical_mass": 74753.0, "gene_names": "Tgfbi;BIGH3;Big-h3;Tgfbi", "protein_name": "Transforming growth factor-beta-induced protein ig-h3", "disease": [ { "disease_id": "DOID:0060444", "name": "granular corneal dystrophy 2", "description": "An corneal granular dystrophy that is characterized by recurrent erosions and stellate or thorn-like opacification located_in the cornea, hyaline and amyloid deposits in the stroma, and progressive vision loss later in life, and has_material_basis_in autosomal dominant inheritance of mutation of transforming growth factor beta-induced gene on chromosome 5q31.1, which encodes keratoepithelin. 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Abnormalities lead to increased protein deposition and disruption especially of Bowman's membrane of the cornea.", "url": "https://disease-ontology.org/term/DOID:0060453", "evidence": [ { "id": "0060453", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060453" } ], "weight": 0.0 }, { "disease_id": "DOID:0060455", "name": "Thiel-Behnke corneal dystrophy", "description": "An epithelial-stromal TGFBI dystrophy that is characterized by recurrent erosions and honeycomb-shaped opacification located_in the cornea, proteinaceous deposits in the anterior stroma and subepithelium, and progressive early vision loss, and has_material_basis_in autosomal dominant inheritance of heterozygous mutation of transforming growth factor beta-induced gene located in chromosome 5q31.1, which encodes keratoepithelin. Abnormalities lead to increased protein deposition and disruption especially of Bowman's membrane of the cornea.", "url": "https://disease-ontology.org/term/DOID:0060455", "evidence": [ { "id": "0060455", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060455" } ], "weight": 0.0 }, { "disease_id": "DOID:0080530", "name": "granular corneal dystrophy 1", "description": "A granular corneal dystrophy that is characterized by recurrent erosions and gray crumb-like opacification located_in the cornea, proteinaceous rock candy-like deposits in the anterior stroma and subepithelium, and progressive vision loss later in life as deposits move into the central vision, and has_material_basis_in autosomal dominant inheritance of heterozygous mutation of transforming growth factor beta-induced gene located in chromosome 5q31.1, which encodes keratoepithelin. 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"name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "F1M9V0", "url": "https://www.uniprot.org/uniprotkb/F1M9V0" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 741, "chemical_mass": 77901.0, "gene_names": "Atxn7l1;Atxn7l1;Atxn7l4;RGD1305730;RGD1564242", "protein_name": "", "disease": [ { "disease_id": "DOID:0050958", "name": "spinocerebellar ataxia 7", "description": "An autosomal dominant cerebellar ataxia that is characterized by ataxia, progressive vision loss, and failure to thrive, has_material_basis_in mutation in the ATXN7 gene.", "url": "https://disease-ontology.org/term/DOID:0050958", "evidence": [ { "id": "0050958", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050958" } ], "weight": 0.0 } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "F1M9V0-1" }, { "uniprot_canonical_ac": "D4A5A6-1", "species": [ { "name": "Rattus 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and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 } ], "biological_process": [ { "name": "positive regulation of RNA splicing", "id": "GO:0033120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033120", "evidence": [ { "database": "UniProtKB", "id": "D4A5A6", "url": "https://www.uniprot.org/uniprotkb/D4A5A6" } ], "pmid": "" }, { "name": "transcription by RNA polymerase II", "id": "GO:0006366", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", "evidence": [ { "database": "UniProtKB", "id": "D4A5A6", "url": "https://www.uniprot.org/uniprotkb/D4A5A6" } ], "pmid": "" }, { "name": "transcription initiation at RNA polymerase II promoter", "id": "GO:0006367", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006367", "evidence": [ { "database": "UniProtKB", "id": "D4A5A6", "url": 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"UniProtKB", "id": "D4A5A6", "url": "https://www.uniprot.org/uniprotkb/D4A5A6" } ], "pmid": "" }, { "name": "cellular response to oxygen levels", "id": "GO:0071453", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071453", "evidence": [ { "database": "UniProtKB", "id": "D4A5A6", "url": "https://www.uniprot.org/uniprotkb/D4A5A6" } ], "pmid": "" } ], "molecular_function": [ { "name": "RNA-directed RNA polymerase activity", "id": "GO:0003968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003968", "evidence": [ { "database": "UniProtKB", "id": "D4A5A6", "url": "https://www.uniprot.org/uniprotkb/D4A5A6" } ], "pmid": "" }, { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "D4A5A6", "url": "https://www.uniprot.org/uniprotkb/D4A5A6" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "D4A5A6", "url": "https://www.uniprot.org/uniprotkb/D4A5A6" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "D4A5A6", "url": "https://www.uniprot.org/uniprotkb/D4A5A6" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "D4A5A6", "url": "https://www.uniprot.org/uniprotkb/D4A5A6" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "D4A5A6", "url": "https://www.uniprot.org/uniprotkb/D4A5A6" } ], "pmid": "" }, { "name": "kinase binding", "id": "GO:0019900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900", "evidence": [ { "database": "UniProtKB", "id": "D4A5A6", "url": "https://www.uniprot.org/uniprotkb/D4A5A6" } ], "pmid": "" }, { "name": "core promoter sequence-specific DNA binding", "id": "GO:0001046", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001046", "evidence": [ { "database": "UniProtKB", "id": "D4A5A6", "url": "https://www.uniprot.org/uniprotkb/D4A5A6" } ], "pmid": "" }, { "name": "microfibril binding", "id": "GO:0050436", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050436", "evidence": [ { "database": "UniProtKB", "id": "D4A5A6", "url": "https://www.uniprot.org/uniprotkb/D4A5A6" } ], "pmid": "" }, { "name": "promoter-specific chromatin binding", "id": "GO:1990841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990841", "evidence": [ { "database": "UniProtKB", "id": "D4A5A6", "url": "https://www.uniprot.org/uniprotkb/D4A5A6" } ], "pmid": "" }, { "name": "DNA-directed RNA polymerase activity", "id": "GO:0003899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003899", "evidence": [ { "database": "UniProtKB", "id": "D4A5A6", "url": "https://www.uniprot.org/uniprotkb/D4A5A6" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "D4A5A6", "url": "https://www.uniprot.org/uniprotkb/D4A5A6" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "D4A5A6", "url": "https://www.uniprot.org/uniprotkb/D4A5A6" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "D4A5A6", "url": "https://www.uniprot.org/uniprotkb/D4A5A6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "D4A5A6", "url": "https://www.uniprot.org/uniprotkb/D4A5A6" } ], "pmid": "" }, { 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"" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "F1M288-1" }, { "uniprot_canonical_ac": "F1M2B7-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "F1M2B7", "url": "https://www.uniprot.org/uniprotkb/F1M2B7" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 1544, "chemical_mass": 165094.0, "gene_names": "Gli2;Gli2", "protein_name": "", "disease": [ { "disease_id": "DOID:0050338", "name": "primary bacterial infectious disease", "description": "A bacterial infectious disease that results_in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread.", "url": "https://disease-ontology.org/term/DOID:0050338", "evidence": [ { "id": "0050338", "database": "AGR", "url": 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"evidence": [ { "database": "UniProtKB", "id": "F7EN82", "url": "https://www.uniprot.org/uniprotkb/F7EN82" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "F7EN82", "url": "https://www.uniprot.org/uniprotkb/F7EN82" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F7EN82", "url": "https://www.uniprot.org/uniprotkb/F7EN82" } ], "pmid": "" } ], "biological_process": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F7EN82", "url": "https://www.uniprot.org/uniprotkb/F7EN82" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "F7EN82-1" }, { "uniprot_canonical_ac": "F7EPZ4-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "F7EPZ4", "url": "https://www.uniprot.org/uniprotkb/F7EPZ4" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 1026, "chemical_mass": 116598.0, "gene_names": "Dis3", "protein_name": "Exosome complex exonuclease RRP44", "disease": [ { "disease_id": "DOID:5426", "name": "primary ovarian insufficiency", "description": "An ovarian disease where ovaries do not produce estrogen despite high levels of circulating gonadotropins in women under 40.", "url": "https://disease-ontology.org/term/DOID:5426", "evidence": [ { "id": "5426", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5426" } ], "weight": 0.0 }, { "disease_id": "DOID:9538", "name": "multiple myeloma", "description": "A myeloid neoplasm that is located_in the plasma cells in bone marrow.", "url": "https://disease-ontology.org/term/DOID:9538", "evidence": [ { "id": "9538", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9538" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F7EPZ4", "url": "https://www.uniprot.org/uniprotkb/F7EPZ4" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "F7EPZ4", "url": "https://www.uniprot.org/uniprotkb/F7EPZ4" } ], "pmid": "" }, { "name": "endonuclease activity", "id": "GO:0004519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004519", "evidence": [ { "database": "UniProtKB", "id": "F7EPZ4", "url": "https://www.uniprot.org/uniprotkb/F7EPZ4" } ], "pmid": "" }, { "name": "3'-5'-RNA exonuclease activity", "id": "GO:0000175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000175", "evidence": [ { "database": "UniProtKB", "id": "F7EPZ4", "url": "https://www.uniprot.org/uniprotkb/F7EPZ4" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F7EPZ4", "url": "https://www.uniprot.org/uniprotkb/F7EPZ4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F7EPZ4", "url": "https://www.uniprot.org/uniprotkb/F7EPZ4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F7EPZ4", "url": "https://www.uniprot.org/uniprotkb/F7EPZ4" } ], "pmid": "" }, { "name": "nuclear exosome (RNase complex)", "id": "GO:0000176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000176", "evidence": [ { "database": "UniProtKB", "id": "F7EPZ4", "url": "https://www.uniprot.org/uniprotkb/F7EPZ4" } ], "pmid": "" }, { "name": "cytoplasmic exosome (RNase complex)", "id": "GO:0000177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000177", "evidence": [ { "database": "UniProtKB", "id": "F7EPZ4", "url": "https://www.uniprot.org/uniprotkb/F7EPZ4" } ], "pmid": "" }, { "name": "exosome (RNase complex)", "id": "GO:0000178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000178", "evidence": [ { "database": "UniProtKB", "id": "F7EPZ4", "url": "https://www.uniprot.org/uniprotkb/F7EPZ4" } ], "pmid": "" } ], "biological_process": [ { "name": "RNA processing", "id": "GO:0006396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006396", "evidence": [ { "database": "UniProtKB", "id": "F7EPZ4", "url": "https://www.uniprot.org/uniprotkb/F7EPZ4" } ], "pmid": "" }, { "name": "rRNA processing", "id": "GO:0006364", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0071031", "evidence": [ { "database": "UniProtKB", "id": "F7EPZ4", "url": "https://www.uniprot.org/uniprotkb/F7EPZ4" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "F7EPZ4-1" }, { "uniprot_canonical_ac": "F7EYS3-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "F7EYS3", "url": "https://www.uniprot.org/uniprotkb/F7EYS3" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 648, "chemical_mass": 75539.0, "gene_names": "Fsip2l1;RGD1564955", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "F7EYS3-1" }, { "uniprot_canonical_ac": "F7FAJ1-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "F7FAJ1", "url": "https://www.uniprot.org/uniprotkb/F7FAJ1" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 526, "chemical_mass": 60237.0, "gene_names": "Cyp2r1", "protein_name": "Vitamin D 25-hydroxylase", "disease": [ { "disease_id": "DOID:0080887", "name": "vitamin D-dependent rickets type 1B", "description": "A vitamin D-dependent rickets that is characterized by abnormally low levels of calcitriol and that has_material_basis_in homozygous, compound heterozygous, or heterozygous mutation in the CYP2R1 gene on chromosome 11p15.", "url": "https://disease-ontology.org/term/DOID:0080887", "evidence": [ { "id": "0080887", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080887" } ], "weight": 0.0 }, { "disease_id": "DOID:10591", "name": "pre-eclampsia", "description": "A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy.", "url": 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which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:3393", "name": "coronary artery disease", "description": "An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.", "url": "https://disease-ontology.org/term/DOID:3393", "evidence": [ { "id": "3393", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3393" } ], "weight": 0.0 }, { "disease_id": "DOID:3454", "name": "brain infarction", "description": "A cerebrovascular disease that is characterized by tissue necrosis located_in the brain, resulting from inadequate blood flow through the brain.", "url": "https://disease-ontology.org/term/DOID:3454", "evidence": [ { "id": "3454", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3454" } ], "weight": 0.0 }, { "disease_id": "DOID:4248", "name": "coronary stenosis", "description": "", "url": "https://disease-ontology.org/term/DOID:4248", "evidence": [ { "id": "4248", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4248" } ], "weight": 0.0 }, { "disease_id": "DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.", "url": "https://disease-ontology.org/term/DOID:5844", "evidence": [ { "id": "5844", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ], "weight": 0.0 }, { "disease_id": "DOID:9744", "name": "type 1 diabetes mellitus", "description": "A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production.", "url": "https://disease-ontology.org/term/DOID:9744", "evidence": [ { "id": "9744", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9744" } ], "weight": 0.0 }, { "disease_id": "DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.", "url": "https://disease-ontology.org/term/DOID:9970", "evidence": [ { "id": "9970", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9970" } ], "weight": 0.0 } ], "biological_process": [ { "name": "vitamin D metabolic process", "id": "GO:0042359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042359", "evidence": [ { "database": "UniProtKB", "id": "F7FAJ1", "url": "https://www.uniprot.org/uniprotkb/F7FAJ1" } ], "pmid": "" }, { "name": "response to ionizing radiation", "id": "GO:0010212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010212", "evidence": [ { "database": "UniProtKB", "id": "F7FAJ1", "url": "https://www.uniprot.org/uniprotkb/F7FAJ1" } ], "pmid": "" }, { "name": "response to metal ion", "id": "GO:0010038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010038", "evidence": [ { "database": "UniProtKB", "id": "F7FAJ1", "url": "https://www.uniprot.org/uniprotkb/F7FAJ1" } ], "pmid": "" }, { "name": "response to cesium ion", "id": "GO:0010164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010164", "evidence": [ { "database": "UniProtKB", "id": "F7FAJ1", "url": "https://www.uniprot.org/uniprotkb/F7FAJ1" } ], "pmid": "" }, { "name": "calcitriol biosynthetic process from calciol", "id": "GO:0036378", "url": 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inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. 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"https://www.alliancegenome.org/disease/DOID:820" } ], "weight": 0.0 }, { "disease_id": "DOID:898", "name": "autosomal dominant polycystic kidney disease", "description": "A polycystic kidney disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium, inherited in an autosomal dominant fashion.", "url": "https://disease-ontology.org/term/DOID:898", "evidence": [ { "id": "898", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:898" } ], "weight": 0.0 } ], "biological_process": [ { "name": "erythrocyte maturation", "id": "GO:0043249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043249", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "nuclear membrane organization", "id": "GO:0071763", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071763", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "erythrocyte enucleation", "id": "GO:0043131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043131", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "interleukin-4-mediated signaling pathway", "id": "GO:0035771", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035771", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "defense response", "id": "GO:0006952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006952", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "regulation of cell population proliferation", "id": "GO:0042127", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042127", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "response to peptide hormone", "id": "GO:0043434", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043434", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "cytokine-mediated signaling pathway", "id": "GO:0019221", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019221", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "cell surface receptor signaling pathway via JAK-STAT", "id": "GO:0007259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007259", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "growth hormone receptor signaling pathway via JAK-STAT", "id": "GO:0060397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060397", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "gland development", "id": "GO:0048732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048732", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "T-helper 1 cell lineage commitment", "id": "GO:0002296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002296", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "mammary gland morphogenesis", "id": "GO:0060443", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060443", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "response to cytokine", "id": "GO:0034097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034097", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "cellular response to hydrogen peroxide", "id": "GO:0070301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070301", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "negative regulation of type 2 immune response", "id": "GO:0002829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002829", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "gene expression", "id": "GO:0010467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010467", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "mammary gland epithelial cell proliferation", "id": "GO:0033598", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033598", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "cellular response to reactive nitrogen species", "id": "GO:1902170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902170", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "positive regulation of isotype switching to IgE isotypes", "id": "GO:0048295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048295", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "positive regulation of cold-induced thermogenesis", "id": "GO:0120162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120162", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "negative regulation of complement-dependent cytotoxicity", "id": "GO:1903660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903660", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" } ], "cellular_component": [ { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "nuclear inner membrane", "id": "GO:0005637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005637", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulator complex", "id": "GO:0090575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090575", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" } ], "molecular_function": [ { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "M0R7R7", "url": "https://www.uniprot.org/uniprotkb/M0R7R7" } ], "pmid": "" }, { "name": "RNA polymerase II transcription 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"binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "M0R7R7-1" }, { "uniprot_canonical_ac": "M0R7V1-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "M0R7V1", "url": "https://www.uniprot.org/uniprotkb/M0R7V1" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 347, "chemical_mass": 38444.0, "gene_names": "Dedd2;LOC687118", "protein_name": "DNA-binding death effector domain-containing protein 2", "disease": [], "molecular_function": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "M0R7V1", "url": "https://www.uniprot.org/uniprotkb/M0R7V1" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "M0R7V1", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0008625", "evidence": [ { "database": "UniProtKB", "id": "M0R7V1", "url": "https://www.uniprot.org/uniprotkb/M0R7V1" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "M0R7V1-1" }, { "uniprot_canonical_ac": "M0R810-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "M0R810", "url": "https://www.uniprot.org/uniprotkb/M0R810" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 410, "chemical_mass": 47163.0, "gene_names": "Tesl2;RGD1566387;Tesl2", "protein_name": "Testin", "disease": [ { "disease_id": "DOID:0080144", "name": "childhood acute lymphocytic leukemia", "description": "An acute lymphocytic leukemia occurring during childhood.", "url": "https://disease-ontology.org/term/DOID:0080144", "evidence": [ { "id": "0080144", "database": "AGR", "url": 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"https://glygen.org/publication/PubMed/24090084" } ] } ] } ], "record_id": "P28841-1" }, { "uniprot_canonical_ac": "P49134-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 799, "chemical_mass": 88495.0, "gene_names": "Itgb1;Itgb1", "protein_name": "Integrin beta-1", "disease": [ { "disease_id": "DOID:0050457", "name": "Sertoli cell-only syndrome", "description": "A male infertility disease characterized by male sterility, has_material_basis_in azospermia without abnormal sexual development.", "url": "https://disease-ontology.org/term/DOID:0050457", "evidence": [ { "id": "0050457", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050457" } ], "weight": 0.0 }, { "disease_id": "DOID:10487", "name": "Hirschsprung's disease", "description": "A megacolon that is characterized by a blockage of the large intestine due to improper muscle movement in the bowel.", "url": "https://disease-ontology.org/term/DOID:10487", "evidence": [ { "id": "10487", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10487" } ], "weight": 0.0 }, { "disease_id": "DOID:10908", "name": "hydrocephalus", "description": "A cerebral degeneration characterized by an abnormal accumulation of cerebrospinal fluid in the ventricles of the brain, leading to progressive enlargement of the head.", "url": "https://disease-ontology.org/term/DOID:10908", "evidence": [ { "id": "10908", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10908" } ], "weight": 0.0 }, { "disease_id": "DOID:162", "name": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.", "url": "https://disease-ontology.org/term/DOID:162", "evidence": [ { "id": "162", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:162" } ], "weight": 0.0 }, { "disease_id": "DOID:2921", "name": "glomerulonephritis", "description": "A nephritis that causes inflammation of the glomeruli located_in kidney.", "url": "https://disease-ontology.org/term/DOID:2921", "evidence": [ { "id": "2921", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2921" } ], "weight": 0.0 }, { "disease_id": "DOID:2986", "name": "IgA glomerulonephritis", "description": "A glomerulonephritis characterized by build up of IgA antibody in the glomerulus.", "url": "https://disease-ontology.org/term/DOID:2986", "evidence": [ { "id": "2986", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2986" } ], "weight": 0.0 }, { "disease_id": "DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.", "url": "https://disease-ontology.org/term/DOID:3908", "evidence": [ { "id": "3908", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ], "weight": 0.0 }, { "disease_id": "DOID:5409", "name": "lung small cell carcinoma", "description": "A lung carcinoma that has_material_basis_in primitive-appearing cells that are smaller than normal cells and is located_in the lung.", "url": "https://disease-ontology.org/term/DOID:5409", "evidence": [ { "id": "5409", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5409" } ], "weight": 0.0 }, { "disease_id": "DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.", "url": "https://disease-ontology.org/term/DOID:5844", "evidence": [ { "id": "5844", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "myelin sheath abaxonal region", "id": "GO:0035748", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035748", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "neuromuscular junction", "id": "GO:0031594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031594", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "dendritic spine", "id": "GO:0043197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043197", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "membrane raft", "id": "GO:0045121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "recycling endosome", "id": "GO:0055037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "intercalated disc", "id": "GO:0014704", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014704", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "melanosome", "id": "GO:0042470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042470", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "filopodium", "id": "GO:0030175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030175", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "sarcolemma", "id": "GO:0042383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "ruffle membrane", "id": "GO:0032587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032587", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "synaptic membrane", "id": "GO:0097060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097060", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "hemidesmosome", "id": "GO:0030056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030056", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "integrin alpha7-beta1 complex", "id": "GO:0034677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034677", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "integrin alpha9-beta1 complex", "id": "GO:0034679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034679", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "integrin alpha4-beta1 complex", "id": "GO:0034668", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034668", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "glycinergic synapse", "id": "GO:0098690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098690", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "integrin complex", "id": "GO:0008305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008305", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "glial cell projection", "id": "GO:0097386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097386", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "integrin alpha3-beta1 complex", "id": "GO:0034667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034667", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "integrin alpha10-beta1 complex", "id": "GO:0034680", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034680", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "integrin alpha11-beta1 complex", "id": "GO:0034681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034681", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "integrin alpha1-beta1 complex", "id": "GO:0034665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034665", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "integrin alpha2-beta1 complex", "id": "GO:0034666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034666", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "Schaffer collateral - CA1 synapse", "id": "GO:0098685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098685", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "integrin alpha5-beta1 complex", "id": "GO:0034674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034674", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "cerebellar climbing fiber to Purkinje cell synapse", "id": "GO:0150053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150053", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "integrin alphav-beta1 complex", "id": "GO:0034682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034682", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "integrin alpha6-beta1 complex", "id": "GO:0034675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034675", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" } ], "biological_process": [ { "name": "cell fate specification", "id": "GO:0001708", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001708", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "response to transforming growth factor beta", "id": "GO:0071559", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071559", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "calcium-independent cell-matrix adhesion", "id": "GO:0007161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007161", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "CD40 signaling pathway", "id": "GO:0023035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0023035", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "angiogenesis", "id": "GO:0001525", 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"https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "visual learning", "id": "GO:0008542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008542", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "positive regulation of neuron projection development", "id": "GO:0010976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010976", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "neuron projection development", "id": "GO:0031175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031175", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "receptor internalization", "id": "GO:0031623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031623", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "positive regulation of GTPase activity", "id": "GO:0043547", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043547", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "negative regulation of neuron differentiation", "id": "GO:0045665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045665", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "positive regulation of neuron 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"response to nutrient levels", "id": "GO:0031667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031667", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "positive regulation of angiogenesis", "id": "GO:0045766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045766", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "cell-matrix adhesion", "id": "GO:0007160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "cell adhesion mediated by integrin", "id": "GO:0033627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033627", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "cell-cell adhesion 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tethering or rolling", "id": "GO:0050901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050901", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "cardiac muscle cell differentiation", "id": "GO:0055007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055007", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "negative regulation of vasoconstriction", "id": "GO:0045906", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045906", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "negative regulation of cell differentiation", "id": "GO:0045596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045596", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "response to xenobiotic stimulus", "id": "GO:0009410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009410", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "positive regulation of fibroblast migration", "id": "GO:0010763", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010763", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "cell projection organization", "id": "GO:0030030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030030", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "negative regulation of Rho protein signal transduction", "id": "GO:0035024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035024", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], 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"pmid": "" }, { "name": "establishment of Sertoli cell barrier", "id": "GO:0097368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097368", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "myoblast differentiation", "id": "GO:0045445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045445", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "cellular response to ionizing radiation", "id": "GO:0071479", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071479", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "axon extension", "id": "GO:0048675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048675", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { 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"https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "heterotypic cell-cell adhesion", "id": "GO:0034113", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034113", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "response to gonadotropin", "id": "GO:0034698", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034698", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "basement membrane organization", "id": "GO:0071711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071711", "evidence": [ { "database": "UniProtKB", "id": "P49134", "url": "https://www.uniprot.org/uniprotkb/P49134" } ], "pmid": "" }, { "name": "positive regulation of fibroblast growth factor receptor signaling pathway", "id": "GO:0045743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045743", "evidence": [ { "database": "UniProtKB", 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"database": "UniProtKB", "id": "A0A0G2JVL6", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JVL6" } ], "pmid": "" }, { "name": "mitochondrial intermembrane space", "id": "GO:0005758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005758", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JVL6", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JVL6" } ], "pmid": "" }, { "name": "respiratory chain complex I", "id": "GO:0045271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045271", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JVL6", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JVL6" } ], "pmid": "" } ], "molecular_function": [ { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JVL6", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JVL6" } ], "pmid": "" } ], "biological_process": [ { "name": "mitochondrial electron transport, NADH to ubiquinone", "id": "GO:0006120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006120", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JVL6", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JVL6" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A0A0G2JVL6-1" }, { "uniprot_canonical_ac": "A0A0G2JWM7-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 192, "chemical_mass": 21459.0, "gene_names": "Ifnl1;Ifnl3;Ifnl1;Il28b", "protein_name": "", "disease": [ { "disease_id": "DOID:0080600", "name": "COVID-19", "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum.", "url": "https://disease-ontology.org/term/DOID:0080600", "evidence": [ { "id": "0080600", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080600" } ], "weight": 0.0 }, { "disease_id": "DOID:12205", "name": "dengue disease", "description": "A viral infectious disease that results in infection, has_material_basis_in Dengue virus (Orthoflavivirus denguei), which are transmitted by Aedes mosquito bite. The infection has symptom fever, has symptom severe headache, has symptom severe pain behind the eyes, has symptom joint pain, has symptom muscle and bone pain, has symptom rash, and has symptom mild bleeding.", "url": "https://disease-ontology.org/term/DOID:12205", "evidence": [ { "id": "12205", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12205" } ], "weight": 0.0 }, { "disease_id": "DOID:12206", "name": "dengue hemorrhagic fever", "description": "A dengue disease that occurs when a person experiences a second infection with a heterologous Dengue virus (Orthoflavivirus denguei) serotype, which is transmitted_by Aedes mosquito bite. The infection has_symptom hemorrhagic lesions of the skin, has_symptom thrombocytopenia, has_symptom reduction in the fluid part of the blood, and has_symptom high fever. Four distinct Dengue virus serotypes have been identified.", "url": "https://disease-ontology.org/term/DOID:12206", "evidence": [ { "id": "12206", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12206" } ], "weight": 0.0 }, { "disease_id": "DOID:1588", "name": "thrombocytopenia", "description": "A blood platelet disease that is characterized by low a platelet count in the blood.", "url": "https://disease-ontology.org/term/DOID:1588", "evidence": [ { "id": "1588", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1588" } ], "weight": 0.0 }, { "disease_id": "DOID:1883", "name": "hepatitis C", "description": "A viral hepatitis that results_in inflammation located_in liver, has_material_basis_in hepatitis C virus (Hepacivirus hominis), which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.", "url": "https://disease-ontology.org/term/DOID:1883", "evidence": [ { "id": "1883", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1883" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:2917", "name": "cryoglobulinemia", "description": "A hypersensitivity reaction type IV disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.", "url": "https://disease-ontology.org/term/DOID:2917", "evidence": [ { "id": "2917", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2917" } ], "weight": 0.0 }, { "disease_id": "DOID:321", "name": "HTLV-1-associated myelopathy/tropical spastic paraparesis", "description": "A viral infectious disease that results in inflammation located in spinal cord, has_material_basis_in human T-cell leukemia virus type 1 (Deltaretrovirus priTlym1), which is transmitted by sexual contact, and transmitted by breast feeding. The infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms.", "url": "https://disease-ontology.org/term/DOID:321", "evidence": [ { "id": "321", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:321" } ], "weight": 0.0 }, { "disease_id": "DOID:5082", "name": "liver cirrhosis", "description": "", "url": "https://disease-ontology.org/term/DOID:5082", "evidence": [ { "id": "5082", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5082" } ], "weight": 0.0 }, { "disease_id": "DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.", "url": "https://disease-ontology.org/term/DOID:684", "evidence": [ { "id": "684", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:684" } ], "weight": 0.0 }, { "disease_id": "DOID:8970", "name": "subacute sclerosing panencephalitis", "description": "A viral encephalitis that has_material_basis_in persistent central nervous system infection of the wild-type measles virus (Morbillivirus hominis) characterized by onset of personality or behavioral changes and intellectual deterioriation years after initial infection, followed by progressive decline in motor function, akinetic mutism or coma, and death. Higher incidence or shorter latency periods may be observed in those initially infected under the age of 2 or in cases of intrafamilial transmission.", "url": "https://disease-ontology.org/term/DOID:8970", "evidence": [ { "id": "8970", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8970" } ], "weight": 0.0 } ], "biological_process": [ { "name": "negative regulation of interleukin-5 production", "id": "GO:0032714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032714", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "positive regulation of type II interferon production", "id": "GO:0032729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032729", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "positive regulation of receptor signaling pathway via JAK-STAT", "id": "GO:0046427", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046427", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "negative regulation of type 2 immune response", "id": "GO:0002829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "positive regulation of tyrosine phosphorylation of STAT protein", "id": "GO:0042531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042531", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "positive regulation of immune response", "id": "GO:0050778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050778", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "positive regulation of MHC class I biosynthetic process", "id": "GO:0045345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045345", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "cell surface receptor signaling pathway via JAK-STAT", "id": "GO:0007259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007259", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "negative regulation of T cell differentiation", "id": "GO:0045581", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045581", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "negative regulation of interleukin-13 production", "id": "GO:0032696", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032696", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "negative regulation of memory T cell differentiation", "id": "GO:0043381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043381", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "mucosal immune response", "id": "GO:0002385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002385", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" } ], "molecular_function": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "interleukin-28 receptor binding", "id": "GO:0032003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032003", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" } ], "cellular_component": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" }, { "name": "interleukin-28 receptor complex", "id": "GO:0032002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032002", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWM7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWM7" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A0A0G2JWM7-1" }, { "uniprot_canonical_ac": "A0A0G2JX21-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JX21", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JX21" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 585, "chemical_mass": 66693.0, "gene_names": "Zfp131;Zfp131", "protein_name": "Zinc finger protein 131", "disease": [], "cellular_component": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JX21", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JX21" } ], "pmid": "" }, { "name": "intermediate filament cytoskeleton", "id": "GO:0045111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045111", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JX21", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JX21" } ], "pmid": "" } ], "biological_process": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JX21", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JX21" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JX21", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JX21" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JX21", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JX21" } ], "pmid": "" }, { "name": "regulation of immune system process", "id": "GO:0002682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002682", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JX21", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JX21" } ], "pmid": "" }, { "name": "regulation of cytokine production", "id": "GO:0001817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001817", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JX21", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JX21" } ], "pmid": "" } ], "molecular_function": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JX21", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JX21" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JX21", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JX21" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JX21", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JX21" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { 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"pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "B1WBY7", "url": "https://www.uniprot.org/uniprotkb/B1WBY7" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "B1WBY7-1" }, { "uniprot_canonical_ac": "B1WC69-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "B1WC69", "url": "https://www.uniprot.org/uniprotkb/B1WC69" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 476, "chemical_mass": 52309.0, "gene_names": "Nsun6;Nopd1;Nsun6", "protein_name": "", "disease": [ { "disease_id": "DOID:0050888", "name": "syndromic intellectual disability", "description": "An intellectual disability that is characterized by the presence of associated medical and behavioral sign and symptoms.", "url": 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has_material_basis_in homozygous mutation in the ARL6 gene on chromosome 3q11.", "url": "https://disease-ontology.org/term/DOID:0110125", "evidence": [ { "id": "0110125", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110125" } ], "weight": 0.0 }, { "disease_id": "DOID:0110370", "name": "retinitis pigmentosa 55", "description": "A retinitis pigmentosa that has_material_basis_in mutation in the ARL6 gene on chromosome 3q11.2.", "url": "https://disease-ontology.org/term/DOID:0110370", "evidence": [ { "id": "0110370", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110370" } ], "weight": 0.0 }, { "disease_id": "DOID:1935", "name": "Bardet-Biedl syndrome", "description": "A syndrome that results from mutations in multiple BBS genes affecting cellular cilia structure or function (ciliopathy) resulting in variable presentation and characterized principally by obesity, retinitis pigmentosa,vision loss, polydactyly, mental retardation, 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"B1WC73", "url": "https://www.uniprot.org/uniprotkb/B1WC73" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "B1WC73", "url": "https://www.uniprot.org/uniprotkb/B1WC73" } ], "pmid": "" }, { "name": "protein localization to cilium", "id": "GO:0061512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061512", "evidence": [ { "database": "UniProtKB", "id": "B1WC73", "url": "https://www.uniprot.org/uniprotkb/B1WC73" } ], "pmid": "" }, { "name": "cell projection organization", "id": "GO:0030030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030030", "evidence": [ { "database": "UniProtKB", "id": "B1WC73", "url": "https://www.uniprot.org/uniprotkb/B1WC73" } ], "pmid": "" }, { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "B1WC73", "url": "https://www.uniprot.org/uniprotkb/B1WC73" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "B1WC73", "url": "https://www.uniprot.org/uniprotkb/B1WC73" } ], "pmid": "" }, { "name": "fat cell differentiation", "id": "GO:0045444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045444", "evidence": [ { "database": "UniProtKB", "id": "B1WC73", "url": "https://www.uniprot.org/uniprotkb/B1WC73" } ], "pmid": "" }, { "name": "retina layer formation", "id": "GO:0010842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010842", "evidence": [ { "database": "UniProtKB", "id": "B1WC73", "url": "https://www.uniprot.org/uniprotkb/B1WC73" } ], "pmid": "" }, { "name": "regulation of smoothened signaling pathway", "id": "GO:0008589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008589", "evidence": [ { "database": "UniProtKB", "id": "B1WC73", "url": "https://www.uniprot.org/uniprotkb/B1WC73" } ], "pmid": "" }, { "name": "protein localization to non-motile cilium", "id": "GO:0097499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097499", "evidence": [ { "database": "UniProtKB", "id": "B1WC73", "url": "https://www.uniprot.org/uniprotkb/B1WC73" } ], "pmid": "" }, { "name": "protein transport from ciliary membrane to plasma membrane", "id": "GO:1903445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903445", "evidence": [ { "database": "UniProtKB", "id": "B1WC73", "url": "https://www.uniprot.org/uniprotkb/B1WC73" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "B1WC73-1" }, { "uniprot_canonical_ac": "B2GV55-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "B2GV55", "url": "https://www.uniprot.org/uniprotkb/B2GV55" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 422, "chemical_mass": 46173.0, "gene_names": "Ube2q1;Ube2q1;Ube2q", "protein_name": "E2 ubiquitin-conjugating enzyme", "disease": [], "biological_process": [ { "name": "suckling behavior", "id": "GO:0001967", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001967", "evidence": [ { "database": "UniProtKB", "id": "B2GV55", "url": "https://www.uniprot.org/uniprotkb/B2GV55" } ], "pmid": "" }, { "name": "mating behavior", "id": "GO:0007617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007617", "evidence": [ { "database": "UniProtKB", "id": "B2GV55", "url": "https://www.uniprot.org/uniprotkb/B2GV55" } ], "pmid": "" }, { "name": "fertilization", "id": "GO:0009566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009566", "evidence": [ { "database": "UniProtKB", "id": "B2GV55", "url": "https://www.uniprot.org/uniprotkb/B2GV55" } ], "pmid": "" }, { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "B2GV55", "url": "https://www.uniprot.org/uniprotkb/B2GV55" } ], "pmid": "" }, { "name": "prolactin secretion", "id": "GO:0070459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070459", "evidence": [ { "database": "UniProtKB", "id": "B2GV55", "url": "https://www.uniprot.org/uniprotkb/B2GV55" } ], "pmid": "" }, { "name": "embryo implantation", "id": "GO:0007566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007566", "evidence": [ { "database": "UniProtKB", "id": "B2GV55", "url": "https://www.uniprot.org/uniprotkb/B2GV55" } ], "pmid": "" }, { "name": "reproductive system development", "id": "GO:0061458", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061458", "evidence": [ { "database": "UniProtKB", "id": "B2GV55", "url": "https://www.uniprot.org/uniprotkb/B2GV55" } ], "pmid": "" } ], "molecular_function": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "B2GV55", "url": "https://www.uniprot.org/uniprotkb/B2GV55" } ], "pmid": "" }, { "name": "ubiquitin conjugating enzyme activity", "id": "GO:0061631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061631", "evidence": [ { "database": "UniProtKB", "id": "B2GV55", "url": "https://www.uniprot.org/uniprotkb/B2GV55" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "B2GV55", "url": "https://www.uniprot.org/uniprotkb/B2GV55" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "B2GV55", "url": "https://www.uniprot.org/uniprotkb/B2GV55" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "B2GV55-1" }, { "uniprot_canonical_ac": "B2RYC8-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 610, "chemical_mass": 68977.0, "gene_names": "Irak3;Irak3", "protein_name": "Interleukin-1 receptor-associated kinase 3", "disease": [ { "disease_id": "DOID:11476", "name": "osteoporosis", "description": "A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength.", "url": "https://disease-ontology.org/term/DOID:11476", "evidence": [ { "id": "11476", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11476" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:399", "name": "tuberculosis", "description": "A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.", "url": "https://disease-ontology.org/term/DOID:399", "evidence": [ { "id": "399", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:399" } ], "weight": 0.0 }, { "disease_id": "DOID:5052", "name": "melioidosis", "description": "A primary bacterial infectious disease that results_in infection, has_material_basis_in Burkholderia pseudomallei, which is transmitted_by contact with the contaminated water or soil. The infection has_symptom fever, has_symptom respiratory distress, has_symptom chest pain, and has_symptom stomach pain.", "url": "https://disease-ontology.org/term/DOID:5052", "evidence": [ { "id": "5052", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5052" } ], "weight": 0.0 }, { "disease_id": "DOID:9744", "name": "type 1 diabetes mellitus", "description": "A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production.", "url": "https://disease-ontology.org/term/DOID:9744", "evidence": [ { "id": "9744", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9744" } ], "weight": 0.0 } ], "biological_process": [ { "name": "negative regulation of cytokine-mediated signaling pathway", "id": "GO:0001960", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001960", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "interleukin-1-mediated signaling pathway", "id": "GO:0070498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070498", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "protein phosphorylation", "id": "GO:0006468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "response to lipopolysaccharide", "id": "GO:0032496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032496", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "negative regulation of interleukin-6 production", "id": "GO:0032715", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032715", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "negative regulation of tumor necrosis factor production", "id": "GO:0032720", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032720", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "positive regulation of cytokine production", "id": "GO:0001819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001819", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "response to virus", "id": "GO:0009615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009615", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "positive regulation of canonical NF-kappaB signal transduction", "id": "GO:0043123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "protein autophosphorylation", "id": "GO:0046777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046777", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "negative regulation of canonical NF-kappaB signal transduction", "id": "GO:0043124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043124", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "response to exogenous dsRNA", "id": "GO:0043330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043330", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "negative regulation of protein catabolic process", "id": "GO:0042177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042177", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "response to interleukin-1", "id": "GO:0070555", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070555", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "lipopolysaccharide-mediated signaling pathway", "id": "GO:0031663", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031663", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "negative regulation of interleukin-12 production", "id": "GO:0032695", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032695", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "negative regulation of toll-like receptor signaling pathway", "id": "GO:0034122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034122", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "negative regulation of MAPK cascade", "id": "GO:0043409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043409", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "cytokine-mediated signaling pathway", "id": "GO:0019221", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019221", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "Toll signaling pathway", "id": "GO:0008063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008063", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "negative regulation of macrophage cytokine production", "id": "GO:0010936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010936", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "negative regulation of innate immune response", "id": "GO:0045824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045824", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "response to peptidoglycan", "id": "GO:0032494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032494", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "negative regulation of protein-containing complex disassembly", "id": "GO:0043242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043242", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "positive regulation of macrophage tolerance induction", "id": "GO:0010933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010933", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "regulation of protein-containing complex disassembly", "id": "GO:0043244", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043244", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" } ], "molecular_function": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "protein kinase activity", "id": "GO:0004672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "B2RYC8", "url": "https://www.uniprot.org/uniprotkb/B2RYC8" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "B2RYC8-1" }, { "uniprot_canonical_ac": "B2RYE0-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "B2RYE0", "url": "https://www.uniprot.org/uniprotkb/B2RYE0" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 337, "chemical_mass": 37554.0, "gene_names": "Spdef", "protein_name": "SAM pointed domain-containing Ets transcription factor", "disease": [ { "disease_id": "DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary.", "url": "https://disease-ontology.org/term/DOID:2394", "evidence": [ { "id": "2394", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2394" } ], "weight": 0.0 } ], "biological_process": [ { "name": "negative regulation of cell fate commitment", "id": "GO:0010454", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010454", "evidence": [ { "database": "UniProtKB", "id": "B2RYE0", "url": "https://www.uniprot.org/uniprotkb/B2RYE0" } ], "pmid": "" }, { "name": "positive regulation of cell fate commitment", "id": "GO:0010455", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010455", "evidence": [ { "database": "UniProtKB", "id": "B2RYE0", "url": "https://www.uniprot.org/uniprotkb/B2RYE0" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "B2RYE0", "url": "https://www.uniprot.org/uniprotkb/B2RYE0" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "B2RYE0", "url": "https://www.uniprot.org/uniprotkb/B2RYE0" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "B2RYE0", "url": "https://www.uniprot.org/uniprotkb/B2RYE0" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "B2RYE0", "url": "https://www.uniprot.org/uniprotkb/B2RYE0" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "B2RYE0", "url": "https://www.uniprot.org/uniprotkb/B2RYE0" } ], "pmid": "" }, { "name": "lung goblet cell differentiation", "id": "GO:0060480", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060480", "evidence": [ { "database": "UniProtKB", "id": "B2RYE0", "url": "https://www.uniprot.org/uniprotkb/B2RYE0" } ], "pmid": "" }, { "name": "intestinal epithelial cell development", "id": "GO:0060576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060576", "evidence": [ { "database": "UniProtKB", "id": "B2RYE0", "url": "https://www.uniprot.org/uniprotkb/B2RYE0" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "B2RYE0", "url": "https://www.uniprot.org/uniprotkb/B2RYE0" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "B2RYE0", "url": "https://www.uniprot.org/uniprotkb/B2RYE0" } ], "pmid": "" } ], "molecular_function": [ { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "B2RYE0", "url": "https://www.uniprot.org/uniprotkb/B2RYE0" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "B2RYE0", "url": "https://www.uniprot.org/uniprotkb/B2RYE0" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "B2RYE0", "url": "https://www.uniprot.org/uniprotkb/B2RYE0" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "B2RYE0", "url": "https://www.uniprot.org/uniprotkb/B2RYE0" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "B2RYE0-1", "start_pos": "50", "end_pos": "50", "site_lbl": "Thr50", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 50, "start_aa": "Thr", "end_pos": 50, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr50", "evidence": [ { "id": "GLY_001157", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001157" } ] } ] } ], "record_id": "B2RYE0-1" }, { "uniprot_canonical_ac": "B2RYS2-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "B2RYS2", "url": "https://www.uniprot.org/uniprotkb/B2RYS2" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 109, "chemical_mass": 13388.0, "gene_names": "Uqcrb;Uqcrbl1", "protein_name": "Cytochrome b-c1 complex subunit 7", "disease": [ { "disease_id": "DOID:0080112", "name": "mitochondrial complex III deficiency nuclear type 3", "description": "A mitochondrial complex III deficiency that has_material_basis_in homozygous mutation in the UQCRB gene on chromosome 8q22.", "url": "https://disease-ontology.org/term/DOID:0080112", "evidence": [ { "id": "0080112", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080112" } ], "weight": 0.0 }, { "disease_id": "DOID:1596", "name": "depressive disorder", "description": "A mood disorder characterized by persistent sadness, emptiness, or irritability and decreased ability to function.", "url": 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pairing at meiosis", "id": "GO:0007129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007129", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK1", "url": "https://www.uniprot.org/uniprotkb/D3ZCK1" } ], "pmid": "" }, { "name": "meiotic DNA double-strand break formation", "id": "GO:0042138", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042138", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK1", "url": "https://www.uniprot.org/uniprotkb/D3ZCK1" } ], "pmid": "" } ], "cellular_component": [ { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK1", "url": "https://www.uniprot.org/uniprotkb/D3ZCK1" } ], "pmid": "" }, { "name": "lateral element", "id": "GO:0000800", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000800", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK1", "url": "https://www.uniprot.org/uniprotkb/D3ZCK1" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "D3ZCK1-1" }, { "uniprot_canonical_ac": "D3ZCK2-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZCK2", "url": "https://www.uniprot.org/uniprotkb/D3ZCK2" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 191, "chemical_mass": 21494.0, "gene_names": "Nkiras2;Nkiras2", "protein_name": "NF-kappa-B inhibitor-interacting Ras-like protein 2", "disease": [], "molecular_function": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK2", "url": "https://www.uniprot.org/uniprotkb/D3ZCK2" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK2", "url": "https://www.uniprot.org/uniprotkb/D3ZCK2" } ], "pmid": "" }, { "name": "GTPase activating protein binding", "id": "GO:0032794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032794", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK2", "url": "https://www.uniprot.org/uniprotkb/D3ZCK2" } ], "pmid": "" } ], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK2", "url": "https://www.uniprot.org/uniprotkb/D3ZCK2" } ], "pmid": "" } ], "biological_process": [ { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK2", "url": "https://www.uniprot.org/uniprotkb/D3ZCK2" } ], "pmid": "" }, { "name": "surfactant homeostasis", "id": "GO:0043129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043129", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK2", "url": "https://www.uniprot.org/uniprotkb/D3ZCK2" } ], "pmid": "" }, { "name": "lung alveolus development", "id": "GO:0048286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048286", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK2", "url": "https://www.uniprot.org/uniprotkb/D3ZCK2" } ], "pmid": "" }, { "name": "negative regulation of canonical NF-kappaB signal transduction", "id": "GO:0043124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043124", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK2", "url": "https://www.uniprot.org/uniprotkb/D3ZCK2" } ], "pmid": "" }, { "name": "regulation of canonical NF-kappaB signal transduction", "id": "GO:0043122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043122", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK2", "url": "https://www.uniprot.org/uniprotkb/D3ZCK2" } ], "pmid": "" }, { "name": "regulation of tumor necrosis factor-mediated signaling pathway", "id": "GO:0010803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010803", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK2", "url": "https://www.uniprot.org/uniprotkb/D3ZCK2" } ], "pmid": "" }, { "name": "Ral protein signal transduction", "id": "GO:0032484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032484", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK2", "url": "https://www.uniprot.org/uniprotkb/D3ZCK2" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "D3ZCK2-1" }, { "uniprot_canonical_ac": "D3ZCK6-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZCK6", "url": "https://www.uniprot.org/uniprotkb/D3ZCK6" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 487, "chemical_mass": 57431.0, "gene_names": "Fads2b;Fads2b;Fads2l1;RGD1311224", "protein_name": "", "disease": [ { "disease_id": "DOID:1574", "name": "alcohol use disorder", "description": "A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.", "url": "https://disease-ontology.org/term/DOID:1574", "evidence": [ { "id": "1574", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1574" } ], "weight": 0.0 }, { "disease_id": "DOID:3146", "name": "lipid metabolism disorder", "description": "An inherited metabolic disorder that involves the creation and degradation of lipids.", "url": "https://disease-ontology.org/term/DOID:3146", "evidence": [ { "id": "3146", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3146" } ], "weight": 0.0 } ], "biological_process": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK6", "url": "https://www.uniprot.org/uniprotkb/D3ZCK6" } ], "pmid": "" }, { "name": "unsaturated fatty acid biosynthetic process", "id": "GO:0006636", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006636", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK6", "url": "https://www.uniprot.org/uniprotkb/D3ZCK6" } ], "pmid": "" } ], "cellular_component": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK6", "url": "https://www.uniprot.org/uniprotkb/D3ZCK6" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK6", "url": "https://www.uniprot.org/uniprotkb/D3ZCK6" } ], "pmid": "" } ], "molecular_function": [ { "name": "oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "id": "GO:0016717", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016717", "evidence": [ { "database": "UniProtKB", "id": "D3ZCK6", "url": "https://www.uniprot.org/uniprotkb/D3ZCK6" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "D3ZCK6-1" }, { "uniprot_canonical_ac": "D3ZCM2-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZCM2", "url": "https://www.uniprot.org/uniprotkb/D3ZCM2" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 528, "chemical_mass": 57674.0, "gene_names": "Tbx21;Tbx21", "protein_name": "T-box transcription factor TBX21", "disease": [ { "disease_id": "DOID:0061058", "name": "immunodeficiency 88", "description": "A primary immunodeficiency disease that is characterized by the development of disseminated mycobacterial disease following vaccination with BCG and that has_material_basis_in homozygous mutation in the TBX21 gene on chromosome 17q21.", "url": "https://disease-ontology.org/term/DOID:0061058", "evidence": [ { "id": "0061058", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0061058" } ], "weight": 0.0 }, { "disease_id": "DOID:0080815", "name": "childhood-onset asthma", "description": "A chronic asthma that is characterized by first presentation in early childhood.", "url": "https://disease-ontology.org/term/DOID:0080815", "evidence": [ { "id": "0080815", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080815" } ], "weight": 0.0 }, { "disease_id": "DOID:0080822", "name": "aspirin-induced respiratory disease", "description": "An intrinsic asthma that is characterized by severe and prolonged airway obstruction after the ingestion of aspirin or other non-steroidal anti-inflammatory drugs.", "url": "https://disease-ontology.org/term/DOID:0080822", "evidence": [ { "id": "0080822", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080822" } ], "weight": 0.0 }, { "disease_id": "DOID:0111579", "name": "asthma, nasal polyps, and aspirin intolerance", "description": "A respiratory system disease characterized by asthma, aspirin-induced bronchoconstriction, and nasal polyps.", "url": "https://disease-ontology.org/term/DOID:0111579", "evidence": [ { "id": "0111579", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111579" } ], "weight": 0.0 }, { "disease_id": "DOID:12365", "name": "malaria", "description": "A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.", "url": "https://disease-ontology.org/term/DOID:12365", "evidence": [ { "id": "12365", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12365" } ], "weight": 0.0 }, { "disease_id": "DOID:12930", "name": "dilated cardiomyopathy", "description": "An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently.", "url": "https://disease-ontology.org/term/DOID:12930", "evidence": [ { "id": "12930", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12930" } ], "weight": 0.0 }, { "disease_id": "DOID:13141", "name": "uveitis", "description": "An uveal disease is characterized by inflammation of any of the layers of the uvea of the eye, which includes the iris, ciliary body, and choroid.", "url": "https://disease-ontology.org/term/DOID:13141", "evidence": [ { "id": "13141", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13141" } ], "weight": 0.0 }, { "disease_id": "DOID:2518", "name": "orchitis", "description": "", "url": "https://disease-ontology.org/term/DOID:2518", "evidence": [ { "id": "2518", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2518" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:7188", "name": "autoimmune thyroiditis", "description": "An autoimmune disease of endocrine system that involves inflammation located_in thyroid gland caused by the immune system reacting against its own tissues.", "url": "https://disease-ontology.org/term/DOID:7188", "evidence": [ { "id": "7188", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:7188" } ], "weight": 0.0 }, { "disease_id": "DOID:823", "name": "periapical periodontitis", "description": "", "url": "https://disease-ontology.org/term/DOID:823", "evidence": [ { "id": "823", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:823" } ], "weight": 0.0 }, { "disease_id": "DOID:9415", "name": "allergic asthma", "description": "An extrinsic asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. The disease has_symptom coughing, has_symptom wheezing, has_symptom shortness of breath or has_symptom rapid breathing, and has_symptom chest tightness.", "url": "https://disease-ontology.org/term/DOID:9415", "evidence": [ { "id": "9415", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9415" } ], "weight": 0.0 } ], "biological_process": [ { "name": "cell fate specification", "id": "GO:0001708", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001708", "evidence": [ { "database": "UniProtKB", "id": "D3ZCM2", "url": "https://www.uniprot.org/uniprotkb/D3ZCM2" } ], "pmid": "" }, { "name": "negative regulation of interleukin-2 production", "id": "GO:0032703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032703", "evidence": [ { "database": "UniProtKB", "id": "D3ZCM2", "url": "https://www.uniprot.org/uniprotkb/D3ZCM2" } ], "pmid": "" }, { "name": "negative regulation of T-helper 17 cell differentiation", "id": "GO:2000320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000320", "evidence": [ { "database": "UniProtKB", "id": "D3ZCM2", "url": "https://www.uniprot.org/uniprotkb/D3ZCM2" } ], "pmid": "" }, { "name": "T-helper 1 cell lineage commitment", "id": "GO:0002296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002296", "evidence": [ { "database": "UniProtKB", "id": "D3ZCM2", "url": "https://www.uniprot.org/uniprotkb/D3ZCM2" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "D3ZCM2", "url": "https://www.uniprot.org/uniprotkb/D3ZCM2" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "D3ZCM2", "url": "https://www.uniprot.org/uniprotkb/D3ZCM2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "D3ZCM2", "url": "https://www.uniprot.org/uniprotkb/D3ZCM2" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "D3ZCM2", "url": "https://www.uniprot.org/uniprotkb/D3ZCM2" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "D3ZCM2", "url": "https://www.uniprot.org/uniprotkb/D3ZCM2" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "D3ZCM2", "url": "https://www.uniprot.org/uniprotkb/D3ZCM2" } ], "pmid": "" }, { "name": "leukocyte migration involved in inflammatory response", "id": "GO:0002523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002523", "evidence": [ { "database": "UniProtKB", "id": "D3ZCM2", "url": "https://www.uniprot.org/uniprotkb/D3ZCM2" } ], "pmid": "" }, { "name": "regulation of immune response", "id": "GO:0050776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050776", "evidence": [ { "database": "UniProtKB", "id": "D3ZCM2", "url": "https://www.uniprot.org/uniprotkb/D3ZCM2" } ], "pmid": "" }, { "name": "response to virus", "id": "GO:0009615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009615", "evidence": [ { "database": "UniProtKB", "id": "D3ZCM2", "url": "https://www.uniprot.org/uniprotkb/D3ZCM2" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "D3ZCM2", "url": 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"evidence": [ { "database": "UniProtKB", "id": "D3ZCM2", "url": "https://www.uniprot.org/uniprotkb/D3ZCM2" } ], "pmid": "" }, { "name": "lymphocyte migration", "id": "GO:0072676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072676", "evidence": [ { "database": "UniProtKB", "id": "D3ZCM2", "url": "https://www.uniprot.org/uniprotkb/D3ZCM2" } ], "pmid": "" }, { "name": "T cell differentiation", "id": "GO:0030217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030217", "evidence": [ { "database": "UniProtKB", "id": "D3ZCM2", "url": "https://www.uniprot.org/uniprotkb/D3ZCM2" } ], "pmid": "" }, { "name": "positive regulation of T-helper 1 cell cytokine production", "id": "GO:2000556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000556", "evidence": [ { "database": "UniProtKB", "id": "D3ZCM2", "url": "https://www.uniprot.org/uniprotkb/D3ZCM2" } ], "pmid": "" }, { "name": "negative regulation of T-helper 17 cell lineage commitment", "id": "GO:2000329", "url": 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], "record_id": "D3ZN99-1" }, { "uniprot_canonical_ac": "D3ZNF4-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZNF4", "url": "https://www.uniprot.org/uniprotkb/D3ZNF4" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 514, "chemical_mass": 55671.0, "gene_names": "Tbl1xr1;RGD1560053;Tbl1xr1", "protein_name": "F-box-like/WD repeat-containing protein TBL1XR1", "disease": [ { "disease_id": "DOID:0050155", "name": "sensory system disease", "description": "A nervous system disease which is located in a part of the nervous system responsible for processing sensory information that consists of sensory receptors, neural pathways, and parts of the brain involved in sensory perception. 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"disease": [ { "disease_id": "DOID:5723", "name": "optic atrophy", "description": "An optic nerve disease that is characterized the death of the retinal ganglion cell axons that comprise the optic nerve.", "url": "https://disease-ontology.org/term/DOID:5723", "evidence": [ { "id": "5723", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5723" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "D3ZPF2", "url": "https://www.uniprot.org/uniprotkb/D3ZPF2" } ], "pmid": "" } ], "biological_process": [ { "name": "fatty acid biosynthetic process", "id": "GO:0006633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006633", "evidence": [ { "database": "UniProtKB", "id": "D3ZPF2", "url": "https://www.uniprot.org/uniprotkb/D3ZPF2" } ], "pmid": "" }, { "name": "mitochondrial small ribosomal subunit assembly", "id": "GO:0180026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0180026", "evidence": [ { "database": "UniProtKB", "id": "D3ZPF2", "url": "https://www.uniprot.org/uniprotkb/D3ZPF2" } ], "pmid": "" } ], "molecular_function": [ { "name": "[acyl-carrier-protein] S-malonyltransferase activity", "id": "GO:0004314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004314", "evidence": [ { "database": "UniProtKB", "id": "D3ZPF2", "url": "https://www.uniprot.org/uniprotkb/D3ZPF2" } ], "pmid": "" }, { "name": "RNA folding chaperone", "id": "GO:0140691", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140691", "evidence": [ { "database": "UniProtKB", "id": "D3ZPF2", "url": "https://www.uniprot.org/uniprotkb/D3ZPF2" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "D3ZPF2-1" }, { "uniprot_canonical_ac": "D3ZPW3-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZPW3", "url": "https://www.uniprot.org/uniprotkb/D3ZPW3" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 234, "chemical_mass": 26508.0, "gene_names": "Il27;Il27", "protein_name": "Interleukin-27 subunit alpha", "disease": [ { "disease_id": "DOID:106", "name": "pleural tuberculosis", "description": "An extrapulmonary tuberculosis that results_in lymphocyte-predominant exudative pleural effusion, located_in pleura. This results from an allergic response to tuberculoprotein causing the permeabiltity of the pleural vasculature to alter leading to a sub-pleural caseous focus rupture into the pleural sac.", "url": "https://disease-ontology.org/term/DOID:106", "evidence": [ { "id": "106", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:106" } ], "weight": 0.0 }, { "disease_id": "DOID:10887", "name": "lepromatous leprosy", "description": "A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. This form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas.", "url": "https://disease-ontology.org/term/DOID:10887", "evidence": [ { "id": "10887", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10887" } ], "weight": 0.0 }, { "disease_id": "DOID:11123", "name": "IgA vasculitis", "description": "A hypersensitivity vasculitis that is characterized by purpura (purplish plaques), arthralgia, gastrointestinal upset, and/or glomerulonephritis, and may be related to increased immune response following an infection.", "url": "https://disease-ontology.org/term/DOID:11123", "evidence": [ { "id": "11123", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11123" } ], "weight": 0.0 }, { "disease_id": "DOID:1724", "name": "duodenal ulcer", "description": "", "url": "https://disease-ontology.org/term/DOID:1724", "evidence": [ { "id": "1724", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1724" } ], "weight": 0.0 }, { "disease_id": "DOID:2043", "name": "hepatitis B", "description": "A viral hepatitis that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus (Orthohepadnavirus hominoidei), which is transmitted_by sexual contact, blood transfusions, or fomites like needles or syringes. The infection has_symptom fever, fatigue, loss of appetite, nausea, vomiting, abdominal pain, clay-colored bowel movements, joint pain, and jaundice.", "url": "https://disease-ontology.org/term/DOID:2043", "evidence": [ { "id": "2043", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2043" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:2957", "name": "pulmonary tuberculosis", "description": "A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis.", "url": "https://disease-ontology.org/term/DOID:2957", "evidence": [ { "id": "2957", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2957" } ], "weight": 0.0 }, { "disease_id": "DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:321", "name": "HTLV-1-associated myelopathy/tropical spastic paraparesis", "description": "A viral infectious disease that results in inflammation located in spinal cord, has_material_basis_in human T-cell leukemia virus type 1 (Deltaretrovirus priTlym1), which is transmitted by sexual contact, and transmitted by breast feeding. The infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms.", "url": "https://disease-ontology.org/term/DOID:321", "evidence": [ { "id": "321", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:321" } ], "weight": 0.0 }, { "disease_id": "DOID:399", "name": "tuberculosis", "description": "A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.", "url": "https://disease-ontology.org/term/DOID:399", "evidence": [ { "id": "399", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:399" } ], "weight": 0.0 }, { "disease_id": "DOID:418", "name": "systemic scleroderma", "description": "A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.", "url": "https://disease-ontology.org/term/DOID:418", "evidence": [ { "id": "418", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:418" } ], "weight": 0.0 }, { "disease_id": "DOID:5082", "name": "liver cirrhosis", "description": "", "url": "https://disease-ontology.org/term/DOID:5082", "evidence": [ { "id": "5082", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5082" } ], "weight": 0.0 }, { "disease_id": "DOID:526", "name": "human immunodeficiency virus infectious disease", "description": "A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 (Lentivirus humimdef1) or Human immunodeficiency virus 2 (Lentivirus humimdef2), which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.", "url": "https://disease-ontology.org/term/DOID:526", "evidence": [ { "id": "526", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:526" } ], "weight": 0.0 }, { "disease_id": "DOID:750", "name": "peptic ulcer disease", "description": "", "url": "https://disease-ontology.org/term/DOID:750", "evidence": [ { "id": "750", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:750" } ], "weight": 0.0 }, { "disease_id": "DOID:8515", "name": "Cor pulmonale", "description": "A congestive heart failure that involves a failure of the right side of the heart and is characterized by an enlargement of the right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs.", "url": "https://disease-ontology.org/term/DOID:8515", "evidence": [ { "id": "8515", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8515" } ], "weight": 0.0 }, { "disease_id": "DOID:8568", "name": "infectious mononucleosis", "description": "A viral infectious disease that results in inflammation, located in pharynx, has_material_basis_in Human herpesvirus 4 (Lymphocryptovirus humangamma4) and has symptom fever, has symptom fatigue, has symptom lymphadenopathy, and has symptom splenomegaly.", "url": "https://disease-ontology.org/term/DOID:8568", "evidence": [ { "id": "8568", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8568" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "interleukin-27 receptor binding", "id": "GO:0045523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045523", "evidence": [ { "database": "UniProtKB", "id": "D3ZPW3", "url": "https://www.uniprot.org/uniprotkb/D3ZPW3" } ], "pmid": "" }, { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "D3ZPW3", "url": "https://www.uniprot.org/uniprotkb/D3ZPW3" } ], "pmid": "" }, { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "D3ZPW3", "url": "https://www.uniprot.org/uniprotkb/D3ZPW3" } ], "pmid": "" } ], "biological_process": [ { "name": "regulation of T-helper 1 cell differentiation", "id": "GO:0045625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045625", "evidence": [ { "database": "UniProtKB", "id": "D3ZPW3", "url": "https://www.uniprot.org/uniprotkb/D3ZPW3" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "D3ZPW3", "url": "https://www.uniprot.org/uniprotkb/D3ZPW3" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "D3ZPW3", "url": "https://www.uniprot.org/uniprotkb/D3ZPW3" } ], "pmid": "" }, { "name": "response to bacterium", "id": "GO:0009617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009617", "evidence": [ { "database": "UniProtKB", "id": "D3ZPW3", "url": "https://www.uniprot.org/uniprotkb/D3ZPW3" } ], "pmid": "" }, { "name": "positive regulation of defense response to virus by host", "id": "GO:0002230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002230", "evidence": [ { "database": "UniProtKB", "id": "D3ZPW3", "url": "https://www.uniprot.org/uniprotkb/D3ZPW3" } ], "pmid": "" }, { "name": "positive regulation of type II interferon production", "id": "GO:0032729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032729", "evidence": [ { "database": "UniProtKB", "id": "D3ZPW3", "url": "https://www.uniprot.org/uniprotkb/D3ZPW3" } ], "pmid": "" }, { "name": "regulation of T cell proliferation", "id": "GO:0042129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042129", "evidence": [ { "database": "UniProtKB", "id": "D3ZPW3", "url": "https://www.uniprot.org/uniprotkb/D3ZPW3" } ], "pmid": "" }, { "name": "response to Gram-positive bacterium", "id": "GO:0140459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140459", "evidence": [ { "database": "UniProtKB", "id": "D3ZPW3", "url": "https://www.uniprot.org/uniprotkb/D3ZPW3" } ], "pmid": "" } ], "cellular_component": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "D3ZPW3", "url": "https://www.uniprot.org/uniprotkb/D3ZPW3" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "D3ZPW3", "url": "https://www.uniprot.org/uniprotkb/D3ZPW3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "D3ZPW3", "url": "https://www.uniprot.org/uniprotkb/D3ZPW3" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "D3ZPW3", "url": "https://www.uniprot.org/uniprotkb/D3ZPW3" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "D3ZPW3", "url": "https://www.uniprot.org/uniprotkb/D3ZPW3" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "D3ZPW3-1" }, { "uniprot_canonical_ac": "D3ZQ56-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZQ56", "url": "https://www.uniprot.org/uniprotkb/D3ZQ56" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 371, "chemical_mass": 41579.0, "gene_names": "Polr3f;Polr3f", "protein_name": "DNA-directed RNA polymerase III subunit RPC6", "disease": [ { "disease_id": "DOID:0061071", "name": "immunodeficiency 101", "description": "A primary immunodeficiency disease that is characterized by reactivation of varicella zoster virus (VZV) infection in adulthood after primary childhood infection with VZV and that has_material_basis_in heterozygous mutation in the POLR3F gene on chromosome 20p11.", "url": "https://disease-ontology.org/term/DOID:0061071", "evidence": [ { "id": "0061071", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0061071" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ56", "url": "https://www.uniprot.org/uniprotkb/D3ZQ56" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ56", "url": "https://www.uniprot.org/uniprotkb/D3ZQ56" } ], "pmid": "" }, { "name": "RNA polymerase III complex", "id": "GO:0005666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005666", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ56", "url": "https://www.uniprot.org/uniprotkb/D3ZQ56" } ], "pmid": "" } ], "molecular_function": [ { "name": "4 iron, 4 sulfur cluster binding", "id": "GO:0051539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051539", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ56", "url": "https://www.uniprot.org/uniprotkb/D3ZQ56" } ], "pmid": "" }, { "name": "double-stranded DNA binding", "id": "GO:0003690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ56", "url": "https://www.uniprot.org/uniprotkb/D3ZQ56" } ], "pmid": "" } ], "biological_process": [ { "name": "termination of RNA polymerase III transcription", "id": "GO:0006386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006386", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ56", "url": "https://www.uniprot.org/uniprotkb/D3ZQ56" } ], "pmid": "" }, { "name": "positive regulation of innate immune response", "id": "GO:0045089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045089", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ56", "url": "https://www.uniprot.org/uniprotkb/D3ZQ56" } ], "pmid": "" }, { "name": "transcription initiation at RNA polymerase III promoter", "id": "GO:0006384", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006384", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ56", "url": "https://www.uniprot.org/uniprotkb/D3ZQ56" } ], "pmid": "" }, { "name": "positive regulation of interferon-beta production", "id": "GO:0032728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032728", "evidence": [ { "database": 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