{
    "disease_id": "DOID:0112168",
    "recommended_name": {
        "id": "DOID:0112168",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0112168",
        "name": "autosomal dominant nonsyndromic deafness 77",
        "description": "An autosomal dominant nonsyndromic deafness that has_material_basis_in heterozygous mutation in the ABCC1 gene on chromosome 16p13.11."
    },
    "synonyms": [
        {
            "id": "DOID:0112168",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0112168",
            "name": "DFNA77",
            "description": ""
        },
        {
            "id": "MONDO:0030058",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0030058",
            "name": "hearing loss, autosomal dominant 77",
            "description": ""
        },
        {
            "id": "MONDO:0030058",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0030058",
            "name": "DFNA77",
            "description": ""
        },
        {
            "id": "MONDO:0030058",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0030058",
            "name": "deafness, autosomal dominant 77",
            "description": ""
        },
        {
            "id": "MIM:618915",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/618915",
            "name": "Deafness, autosomal dominant, 77",
            "description": "Deafness, autosomal dominant, 77"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0112168"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0112168",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0112168",
            "categories": []
        },
        {
            "id": "MONDO:0030058",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0030058",
            "categories": []
        },
        {
            "id": "MIM:618915",
            "database": "MIM",
            "url": "https://www.omim.org/entry/618915",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0AB32TKI2-1",
            "uniprot_ac": "A0AB32TKI2",
            "uniprot_id": "A0AB32TKI2_DANRE",
            "refseq_ac": "XP_068075316",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Multidrug resistance-associated protein 1",
                    "type": "recommended"
                },
                {
                    "name": "7.6.2.2",
                    "type": "synonym"
                },
                {
                    "name": "7.6.2.3",
                    "type": "synonym"
                },
                {
                    "name": "ATP-binding cassette sub-family C member 1",
                    "type": "synonym"
                },
                {
                    "name": "Glutathione-S-conjugate-translocating ATPase ABCC1",
                    "type": "synonym"
                },
                {
                    "name": "Leukotriene C(4) transporter",
                    "type": "synonym"
                },
                {
                    "name": "multidrug resistance-associated protein 1 isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "abcc1",
                    "type": "recommended"
                },
                {
                    "name": "abcc1",
                    "type": "synonym"
                }
            ],
            "record_id": "A0AB32TKI2-1",
            "evidence": [
                {
                    "id": "0112168",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0112168"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O35379-1",
            "uniprot_ac": "O35379",
            "uniprot_id": "MRP1_MOUSE",
            "refseq_ac": "NP_032602",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Multidrug resistance-associated protein 1",
                    "type": "recommended"
                },
                {
                    "name": "7.6.2.2",
                    "type": "synonym"
                },
                {
                    "name": "7.6.2.3",
                    "type": "synonym"
                },
                {
                    "name": "ATP-binding cassette sub-family C member 1",
                    "type": "synonym"
                },
                {
                    "name": "ATP-binding cassette, sub-family C (CFTR/MRP), member 1a",
                    "type": "synonym"
                },
                {
                    "name": "ATP-binding cassette, sub-family C (CFTR/MRP), member 1b",
                    "type": "synonym"
                },
                {
                    "name": "Glutathione-S-conjugate-translocating ATPase ABCC1",
                    "type": "synonym"
                },
                {
                    "name": "LTC4 transporter",
                    "type": "synonym"
                },
                {
                    "name": "Leukotriene C(4) transporter",
                    "type": "synonym"
                },
                {
                    "name": "glutathione-S-conjugate-translocating ATPase ABCC1",
                    "type": "synonym"
                },
                {
                    "name": "leukotriene C(4) transporter",
                    "type": "synonym"
                },
                {
                    "name": "multidrug resistance-associated protein 1 isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "multidrug resistance-associated protein 1",
                    "type": "synonym"
                },
                {
                    "name": "multiple drug resistance-associated protein",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Abcc1",
                    "type": "recommended"
                },
                {
                    "name": "Abcc1a",
                    "type": "synonym"
                },
                {
                    "name": "Abcc1b",
                    "type": "synonym"
                },
                {
                    "name": "Abcc1",
                    "type": "synonym"
                },
                {
                    "name": "MRP",
                    "type": "synonym"
                },
                {
                    "name": "Mdrap",
                    "type": "synonym"
                },
                {
                    "name": "Mrp1",
                    "type": "synonym"
                },
                {
                    "name": "Mrp",
                    "type": "synonym"
                }
            ],
            "record_id": "O35379-1",
            "evidence": [
                {
                    "id": "0112168",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0112168"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P33527-1",
            "uniprot_ac": "P33527",
            "uniprot_id": "MRP1_HUMAN",
            "refseq_ac": "NP_004987",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Multidrug resistance-associated protein 1",
                    "type": "recommended"
                },
                {
                    "name": "7.6.2.2",
                    "type": "synonym"
                },
                {
                    "name": "7.6.2.3",
                    "type": "synonym"
                },
                {
                    "name": "ATP-binding cassette sub-family C member 1",
                    "type": "synonym"
                },
                {
                    "name": "ATP-binding cassette transporter variant ABCC1delta-ex13&14",
                    "type": "synonym"
                },
                {
                    "name": "ATP-binding cassette transporter variant ABCC1delta-ex25&26",
                    "type": "synonym"
                },
                {
                    "name": "ATP-binding cassette, sub-family C (CFTR/MRP), member 1",
                    "type": "synonym"
                },
                {
                    "name": "Glutathione-S-conjugate-translocating ATPase ABCC1",
                    "type": "synonym"
                },
                {
                    "name": "LTC4 transporter",
                    "type": "synonym"
                },
                {
                    "name": "Leukotriene C(4) transporter",
                    "type": "synonym"
                },
                {
                    "name": "glutathione S-conjugate export pump",
                    "type": "synonym"
                },
                {
                    "name": "glutathione-S-conjugate-translocating ATPase ABCC1",
                    "type": "synonym"
                },
                {
                    "name": "leukotriene C(4) transporter",
                    "type": "synonym"
                },
                {
                    "name": "multidrug resistance-associated protein 1 isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "multidrug resistance-associated protein 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "ABCC1",
                    "type": "recommended"
                },
                {
                    "name": "ABC29",
                    "type": "synonym"
                },
                {
                    "name": "ABCC1",
                    "type": "synonym"
                },
                {
                    "name": "ABCC",
                    "type": "synonym"
                },
                {
                    "name": "DFNA77",
                    "type": "synonym"
                },
                {
                    "name": "GS-X",
                    "type": "synonym"
                },
                {
                    "name": "MRP1",
                    "type": "synonym"
                },
                {
                    "name": "MRP",
                    "type": "synonym"
                }
            ],
            "record_id": "P33527-1",
            "evidence": [
                {
                    "id": "618915",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/618915"
                },
                {
                    "id": "0112168",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0112168"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P39109-1",
            "uniprot_ac": "P39109",
            "uniprot_id": "YCFI_YEAST",
            "refseq_ac": "NP_010419",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Metal resistance protein YCF1",
                    "type": "recommended"
                },
                {
                    "name": "7.2.2.2",
                    "type": "synonym"
                },
                {
                    "name": "7.6.2.3",
                    "type": "synonym"
                },
                {
                    "name": "ABC-type Cd(2+) transporter",
                    "type": "synonym"
                },
                {
                    "name": "ABC-type glutathione-S-conjugate transporter",
                    "type": "synonym"
                },
                {
                    "name": "ATP-binding cassette glutathione S-conjugate transporter YCF1",
                    "type": "synonym"
                },
                {
                    "name": "Yeast cadmium factor 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "YCF1",
                    "type": "recommended"
                },
                {
                    "name": "YCF1",
                    "type": "synonym"
                },
                {
                    "name": "YD9302.11C",
                    "type": "synonym"
                }
            ],
            "record_id": "P39109-1",
            "evidence": [
                {
                    "id": "0112168",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0112168"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q8CG09-1",
            "uniprot_ac": "Q8CG09",
            "uniprot_id": "MRP1_RAT",
            "refseq_ac": "NP_071617",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Multidrug resistance-associated protein 1",
                    "type": "recommended"
                },
                {
                    "name": "7.6.2.2",
                    "type": "synonym"
                },
                {
                    "name": "7.6.2.3",
                    "type": "synonym"
                },
                {
                    "name": "ATP-binding cassette sub-family C (CFTR/MRP) member 1a",
                    "type": "synonym"
                },
                {
                    "name": "ATP-binding cassette sub-family C member 1",
                    "type": "synonym"
                },
                {
                    "name": "ATP-binding cassette, sub-family C (CFTR/MRP), member 1",
                    "type": "synonym"
                },
                {
                    "name": "ATP-binding cassette, sub-family C, member 1-like",
                    "type": "synonym"
                },
                {
                    "name": "ATP-binding cassette, subfamily C (CFTR/MRP), member 1",
                    "type": "synonym"
                },
                {
                    "name": "Glutathione-S-conjugate-translocating ATPase ABCC1",
                    "type": "synonym"
                },
                {
                    "name": "LTC4 transporter",
                    "type": "synonym"
                },
                {
                    "name": "Leukotriene C(4) transporter",
                    "type": "synonym"
                },
                {
                    "name": "glutathione-S-conjugate-translocating ATPase ABCC1",
                    "type": "synonym"
                },
                {
                    "name": "leukotriene C(4) transporter",
                    "type": "synonym"
                },
                {
                    "name": "multidrug resistance protein 1",
                    "type": "synonym"
                },
                {
                    "name": "multidrug resistance-associated protein 1-like",
                    "type": "synonym"
                },
                {
                    "name": "multidrug resistance-associated protein 1",
                    "type": "synonym"
                },
                {
                    "name": "multiple drug resistance-associated protein",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Abcc1",
                    "type": "recommended"
                },
                {
                    "name": "LOC134480646",
                    "type": "recommended"
                },
                {
                    "name": "Abcc1a",
                    "type": "synonym"
                },
                {
                    "name": "Abcc1",
                    "type": "synonym"
                },
                {
                    "name": "Avcc1a",
                    "type": "synonym"
                },
                {
                    "name": "LOC688708",
                    "type": "synonym"
                },
                {
                    "name": "Mrp1",
                    "type": "synonym"
                },
                {
                    "name": "Mrp",
                    "type": "synonym"
                }
            ],
            "record_id": "Q8CG09-1",
            "evidence": [
                {
                    "id": "0112168",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0112168"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q7KTC0-1",
            "uniprot_ac": "Q7KTC0",
            "uniprot_id": "Q7KTC0_DROME",
            "refseq_ac": "NP_995693",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "ABC-type glutathione-S-conjugate transporter",
                    "type": "recommended"
                },
                {
                    "name": "7.6.2.3",
                    "type": "synonym"
                },
                {
                    "name": "CG6214-PI",
                    "type": "synonym"
                },
                {
                    "name": "MRP-PI",
                    "type": "synonym"
                },
                {
                    "name": "Multidrug-Resistance like protein 1, isoform I",
                    "type": "synonym"
                },
                {
                    "name": "Multidrug-Resistance like protein 1",
                    "type": "synonym"
                },
                {
                    "name": "Multidrug-resistance protein",
                    "type": "synonym"
                },
                {
                    "name": "multidrug resistance like protein",
                    "type": "synonym"
                },
                {
                    "name": "multidrug resistance-associated protein",
                    "type": "synonym"
                },
                {
                    "name": "multidrug resistance-like protein 1",
                    "type": "synonym"
                },
                {
                    "name": "multidrug resistance-like protein",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "MRP",
                    "type": "recommended"
                },
                {
                    "name": "ABCC1",
                    "type": "synonym"
                },
                {
                    "name": "CG6214",
                    "type": "synonym"
                },
                {
                    "name": "DmCG6214",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG6214",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG6214",
                    "type": "synonym"
                },
                {
                    "name": "MRP1",
                    "type": "synonym"
                },
                {
                    "name": "MRP",
                    "type": "synonym"
                },
                {
                    "name": "Mrp1",
                    "type": "synonym"
                },
                {
                    "name": "Mrp",
                    "type": "synonym"
                },
                {
                    "name": "dMRP/CG6214",
                    "type": "synonym"
                },
                {
                    "name": "dMRP1",
                    "type": "synonym"
                },
                {
                    "name": "dMRP",
                    "type": "synonym"
                },
                {
                    "name": "dmrp",
                    "type": "synonym"
                },
                {
                    "name": "lincRNA.123",
                    "type": "synonym"
                }
            ],
            "record_id": "Q7KTC0-1",
            "evidence": [
                {
                    "id": "0112168",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0112168"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0112168"
}